{
  "trained_at": "2026-08-28T13:42:32.184957+00:00",
  "device": "cpu",
  "n_genes_total": 570,
  "n_train_labeled": 199,
  "n_test_labeled": 102,
  "temporal_split": {
    "train_total": 1504,
    "test_total": 1415,
    "leakage_prevented": 0,
    "no_leak_verified": true
  },
  "baseline": {
    "auroc": 0.1190368014538846,
    "auprc": 0.547004870356739
  },
  "bgcn": {
    "auroc": 0.9213993639254885,
    "auprc": 0.9559666780818283
  },
  "calibration": {
    "slope": 1.039452672944247,
    "intercept": 0.14796603209583445,
    "ece": 0.10702049929429502
  },
  "dca": {
    "passes_gate": true,
    "positive_range": [
      0.01,
      0.97
    ]
  },
  "lrp_fidelity": {
    "mean_fidelity": -0.08218878777653914,
    "median_fidelity": -0.013004715115331498,
    "std_fidelity": 0.37249609903622566,
    "min_fidelity": -1.4798435791581208,
    "n_faithful": 4
  },
  "gates": {
    "auroc_beats_baseline": true,
    "auprc_beats_baseline_margin_0.02": true,
    "calibration_slope_in_range": true,
    "calibration_intercept_in_range": false,
    "dca_net_benefit_positive": true,
    "lrp_fidelity_ge_0.3": false
  },
  "release_status": "RESEARCH_ONLY_NOT_PROMOTED",
  "meta": {
    "n_genes": 570,
    "gene_list": [
      "14q partial distal trisomy syndrome",
      "ABCA7",
      "ABCC2",
      "ABHD17B",
      "ABHD3",
      "ACD",
      "ADAMTS1",
      "ADAMTS9",
      "ADAP2",
      "AIMP2",
      "AKAP11",
      "AKT1",
      "ALK",
      "ALS2",
      "ANG",
      "ANKRD22",
      "ANKRD26",
      "AOPEP",
      "APBA2",
      "APC",
      "APOB",
      "APOB3'MAR",
      "APOE",
      "APP",
      "AR",
      "ARID1A",
      "ASXL1",
      "ATM",
      "ATP13A2",
      "ATR",
      "ATRX",
      "AXIN2",
      "BAP1",
      "BARD1",
      "BAX",
      "BCL10",
      "BCL2",
      "BCL6",
      "BIVM-ERCC5",
      "BRAF",
      "BRCA1",
      "BRCA2",
      "BRIP1",
      "BRK1",
      "C10orf55",
      "C6orf201",
      "C9orf72",
      "CARD11",
      "CASP10",
      "CASP8",
      "CASR",
      "CBL",
      "CCND1",
      "CCNF",
      "CDH1",
      "CDK4",
      "CDK6",
      "CDKN2A",
      "CEBPA",
      "CEP290",
      "CFTR",
      "CFTR-AS1",
      "CFTR-AS2",
      "CHCHD10",
      "CHEK2",
      "CHMP2B",
      "CNTN1",
      "COL18A1",
      "COL4A4",
      "CPSF2",
      "CREBBP",
      "CTAGE1",
      "CTNNA1",
      "CTNNB1",
      "CYLD",
      "Cardiovascular phenotype",
      "DAXX",
      "DCTN1",
      "DDX41",
      "DHCR7",
      "DICER1",
      "DIPK1A",
      "DKC1",
      "DMD",
      "DNAJC6",
      "DNAJC7",
      "DNMT3A",
      "EGFR",
      "EGFR-AS1",
      "EGFR-related lung cancer",
      "EGLN1",
      "ELANE",
      "EP300",
      "EPAS1",
      "EPCAM",
      "ERBB2",
      "ERBB4",
      "ERCC2",
      "ERCC4",
      "ESR1",
      "ETV6",
      "EVI2A",
      "EWSR1",
      "EZH2",
      "FAN1",
      "FANCA",
      "FANCC",
      "FANCD2",
      "FANCE",
      "FANCG",
      "FANCI",
      "FAS",
      "FASLG",
      "FBP2",
      "FBXW7",
      "FH",
      "FLCN",
      "FLT1",
      "FLT3",
      "FMR1",
      "FOXA1",
      "FOXL2",
      "FRONTOTEMPORAL LOBAR DEGENERATION WITH TDP43 INCLUSIONS, TARDBP-RELATED",
      "FUS",
      "FXR2",
      "G6PD",
      "GALNT12",
      "GATA2",
      "GATA3",
      "GBA",
      "GBA1",
      "GBE1",
      "GLE1",
      "GLI1",
      "GLIS2",
      "GNA11",
      "GNAQ",
      "GNAS",
      "GPD1",
      "GRN",
      "H3-3B",
      "H3F3A",
      "HBB",
      "HEATR3",
      "HIF1A",
      "HNRNPA2B1",
      "HRAS",
      "HTT",
      "Hereditary nonpolyposis colorectal neoplasms",
      "IDH1",
      "IDH2",
      "IDH3A",
      "INVS",
      "IQCB1",
      "Inborn genetic diseases",
      "Inherited MMR deficiency (Lynch syndrome)",
      "Inherited breast cancer and ovarian cancer",
      "Inherited ovarian cancer (without breast cancer)",
      "JAK1",
      "JAK2",
      "KDM6A",
      "KDR",
      "KIF1A",
      "KIF5A",
      "KIT",
      "KMT2A",
      "KMT2D",
      "KRAS",
      "LALTOP",
      "LDLR",
      "LDLRAP1",
      "LNCR-SMAL",
      "LOC107303340",
      "LOC108281125",
      "LOC108281182",
      "LOC108903148",
      "LOC110806263",
      "LOC110806306",
      "LOC111674477",
      "LOC114803469",
      "LOC126806050",
      "LOC126807526",
      "LOC126861339",
      "LOC126861451",
      "LOC126862483",
      "LOC126862571",
      "LOC129390965",
      "LOC129937550",
      "LOC130007385",
      "LOC130055403",
      "LOC130062441",
      "LOC132090298",
      "LRRFIP2",
      "LRRK2",
      "LZTR1",
      "Li-Fraumeni syndrome 1",
      "MAP2K1",
      "MAP2K2",
      "MAPT",
      "MATR3",
      "MBD4",
      "MDM2",
      "MDM4",
      "MEN1",
      "MET",
      "MIR6084",
      "MLH1",
      "MLH3",
      "MONDO:0000507",
      "MONDO:0002447",
      "MONDO:0003582",
      "MONDO:0004975",
      "MONDO:0004976",
      "MONDO:0005145",
      "MONDO:0005180",
      "MONDO:0005439",
      "MONDO:0005575",
      "MONDO:0005835",
      "MONDO:0007039",
      "MONDO:0007086",
      "MONDO:0007088",
      "MONDO:0007089",
      "MONDO:0007103",
      "MONDO:0007104",
      "MONDO:0007105",
      "MONDO:0007110",
      "MONDO:0007356",
      "MONDO:0007485",
      "MONDO:0007488",
      "MONDO:0007648",
      "MONDO:0007750",
      "MONDO:0007827",
      "MONDO:0008018",
      "MONDO:0008021",
      "MONDO:0008192",
      "MONDO:0008199",
      "MONDO:0008200",
      "MONDO:0008233",
      "MONDO:0008243",
      "MONDO:0008280",
      "MONDO:0008453",
      "MONDO:0008555",
      "MONDO:0008667",
      "MONDO:0008685",
      "MONDO:0008734",
      "MONDO:0008762",
      "MONDO:0008840",
      "MONDO:0008887",
      "MONDO:0009061",
      "MONDO:0009134",
      "MONDO:0009213",
      "MONDO:0009214",
      "MONDO:0009215",
      "MONDO:0009623",
      "MONDO:0009694",
      "MONDO:0009892",
      "MONDO:0009897",
      "MONDO:0010035",
      "MONDO:0010133",
      "MONDO:0010210",
      "MONDO:0010214",
      "MONDO:0010215",
      "MONDO:0010216",
      "MONDO:0010385",
      "MONDO:0010459",
      "MONDO:0010584",
      "MONDO:0010820",
      "MONDO:0010936",
      "MONDO:0010953",
      "MONDO:0010997",
      "MONDO:0011014",
      "MONDO:0011136",
      "MONDO:0011158",
      "MONDO:0011196",
      "MONDO:0011369",
      "MONDO:0011383",
      "MONDO:0011405",
      "MONDO:0011450",
      "MONDO:0011537",
      "MONDO:0011613",
      "MONDO:0011632",
      "MONDO:0011658",
      "MONDO:0011706",
      "MONDO:0011713",
      "MONDO:0011743",
      "MONDO:0011764",
      "MONDO:0011797",
      "MONDO:0011913",
      "MONDO:0011951",
      "MONDO:0012041",
      "MONDO:0012075",
      "MONDO:0012132",
      "MONDO:0012153",
      "MONDO:0012183",
      "MONDO:0012186",
      "MONDO:0012249",
      "MONDO:0012565",
      "MONDO:0012669",
      "MONDO:0012790",
      "MONDO:0012924",
      "MONDO:0012933",
      "MONDO:0012937",
      "MONDO:0013196",
      "MONDO:0013216",
      "MONDO:0013248",
      "MONDO:0013253",
      "MONDO:0013264",
      "MONDO:0013292",
      "MONDO:0013308",
      "MONDO:0013357",
      "MONDO:0013398",
      "MONDO:0013499",
      "MONDO:0013521",
      "MONDO:0013522",
      "MONDO:0013565",
      "MONDO:0013625",
      "MONDO:0013669",
      "MONDO:0013692",
      "MONDO:0013699",
      "MONDO:0013710",
      "MONDO:0013725",
      "MONDO:0013888",
      "MONDO:0014025",
      "MONDO:0014045",
      "MONDO:0014048",
      "MONDO:0014108",
      "MONDO:0014178",
      "MONDO:0014223",
      "MONDO:0014231",
      "MONDO:0014233",
      "MONDO:0014252",
      "MONDO:0014382",
      "MONDO:0014536",
      "MONDO:0014600",
      "MONDO:0014612",
      "MONDO:0014630",
      "MONDO:0014641",
      "MONDO:0014690",
      "MONDO:0014796",
      "MONDO:0014802",
      "MONDO:0014809",
      "MONDO:0014975",
      "MONDO:0014979",
      "MONDO:0014986",
      "MONDO:0014987",
      "MONDO:0015253",
      "MONDO:0015356",
      "MONDO:0015780",
      "MONDO:0016063",
      "MONDO:0016073",
      "MONDO:0016248",
      "MONDO:0016419",
      "MONDO:0017276",
      "MONDO:0017623",
      "MONDO:0018150",
      "MONDO:0018604",
      "MONDO:0018630",
      "MONDO:0018770",
      "MONDO:0018874",
      "MONDO:0018875",
      "MONDO:0018881",
      "MONDO:0018921",
      "MONDO:0018975",
      "MONDO:0018996",
      "MONDO:0019005",
      "MONDO:0021056",
      "MONDO:0024537",
      "MONDO:0024551",
      "MONDO:0030690",
      "MONDO:0030805",
      "MONDO:0030872",
      "MONDO:0031071",
      "MONDO:0032865",
      "MONDO:0033362",
      "MONDO:0042490",
      "MONDO:0044300",
      "MONDO:0054750",
      "MONDO:0100216",
      "MONDO:0100553",
      "MONDO:0700270",
      "MONDO:0800444",
      "MONDO:0859183",
      "MONDO:0859246",
      "MONDO:0859267",
      "MONDO:0957530",
      "MONDO:0975748",
      "MONDO:0980991",
      "MONDO:8000012",
      "MPO",
      "MSH2",
      "MSH3",
      "MSH6",
      "MTOR",
      "MUTYH",
      "MYC",
      "MYD88",
      "NBN",
      "NEFH",
      "NEK1",
      "NF1",
      "NF2",
      "NOTCH1",
      "NOTCH3",
      "NPHP1",
      "NPHP3",
      "NPHP3-ACAD11",
      "NPHP4",
      "NPM1",
      "NRAS",
      "NTHL1",
      "OLR1",
      "OPTN",
      "OSBPL1A",
      "PALB2",
      "PARK7",
      "PARN",
      "PAX8",
      "PBRM1",
      "PCSK9",
      "PDGFRA",
      "PIK3C2G",
      "PIK3CA",
      "PIK3R1",
      "PIKFYVE",
      "PINK1",
      "PMS1",
      "PMS2",
      "POLD1",
      "POLE",
      "POLH",
      "PRKAG2",
      "PRKAR1A",
      "PRKN",
      "PRPH",
      "PSAP",
      "PSEN1",
      "PSEN2",
      "PTCH1",
      "PTEN",
      "PTPN11",
      "PTRH2",
      "Partial 18p monosomy with 18q trisomy",
      "RAB32",
      "RAD51",
      "RAD51C",
      "RAD51D",
      "RAF1",
      "RB1",
      "REL",
      "RET",
      "RHOT1",
      "RPA1",
      "RPS10",
      "RPS17",
      "RPS19",
      "RPS20",
      "RUNX1",
      "SAMD9L",
      "SDHB",
      "SDHD",
      "SEC23B",
      "SETD2",
      "SETX",
      "SH2D1A",
      "SHOC2",
      "SLC52A3",
      "SLX4",
      "SMAD4",
      "SMARCB1",
      "SMN1",
      "SMO",
      "SNCA",
      "SOCS1",
      "SOD1",
      "SORL1",
      "SOS1",
      "SPG11",
      "SPRED1",
      "SQSTM1",
      "STAG2",
      "STAT3",
      "STK11",
      "SUFU",
      "SUPT16H",
      "SYNJ1",
      "See cases",
      "TAF15",
      "TARDBP",
      "TBK1",
      "TERT",
      "TET2",
      "TINF2",
      "TNFAIP3",
      "TP53",
      "TP53BP1",
      "TRPM7",
      "TSC1",
      "TSC2",
      "TTC21B",
      "Triple-negative breast cancer",
      "UBQLN2",
      "USB1",
      "VAPB",
      "VCP",
      "VEGFA",
      "VHL",
      "VPS13C",
      "VPS35",
      "WT1",
      "XIAP",
      "XPA",
      "XRCC1",
      "XRCC2",
      "ZCCHC8",
      "not provided",
      "not specified",
      "tissue:Adipose_Subcutaneous",
      "tissue:Adipose_Visceral_Omentum",
      "tissue:Adrenal_Gland",
      "tissue:Artery_Aorta",
      "tissue:Artery_Coronary",
      "tissue:Artery_Tibial",
      "tissue:Bladder",
      "tissue:Brain_Amygdala",
      "tissue:Brain_Anterior_cingulate_cortex_BA24",
      "tissue:Brain_Caudate_basal_ganglia",
      "tissue:Brain_Cerebellar_Hemisphere",
      "tissue:Brain_Cerebellum",
      "tissue:Brain_Cortex",
      "tissue:Brain_Frontal_Cortex_BA9",
      "tissue:Brain_Hippocampus",
      "tissue:Brain_Hypothalamus",
      "tissue:Brain_Nucleus_accumbens_basal_ganglia",
      "tissue:Brain_Putamen_basal_ganglia",
      "tissue:Brain_Spinal_cord_cervical_c-1",
      "tissue:Brain_Substantia_nigra",
      "tissue:Breast_Mammary_Tissue",
      "tissue:Cells_Cultured_fibroblasts",
      "tissue:Cells_EBV-transformed_lymphocytes",
      "tissue:Cervix_Ectocervix",
      "tissue:Cervix_Endocervix",
      "tissue:Colon_Sigmoid",
      "tissue:Colon_Transverse",
      "tissue:Esophagus_Gastroesophageal_Junction",
      "tissue:Esophagus_Mucosa",
      "tissue:Esophagus_Muscularis",
      "tissue:Fallopian_Tube",
      "tissue:Heart_Atrial_Appendage",
      "tissue:Heart_Left_Ventricle",
      "tissue:Kidney_Cortex",
      "tissue:Kidney_Medulla",
      "tissue:Liver",
      "tissue:Lung",
      "tissue:Minor_Salivary_Gland",
      "tissue:Muscle_Skeletal",
      "tissue:Nerve_Tibial",
      "tissue:Ovary",
      "tissue:Pancreas",
      "tissue:Pituitary",
      "tissue:Prostate",
      "tissue:Skin_Not_Sun_Exposed_Suprapubic",
      "tissue:Skin_Sun_Exposed_Lower_leg",
      "tissue:Small_Intestine_Terminal_Ileum",
      "tissue:Spleen",
      "tissue:Stomach",
      "tissue:Testis",
      "tissue:Thyroid",
      "tissue:Uterus",
      "tissue:Vagina",
      "tissue:Whole_Blood"
    ],
    "n_positive": 226,
    "n_negative": 93,
    "n_unlabeled": 251,
    "seed_genes": [
      "TP53",
      "BRCA1",
      "BRCA2",
      "PTEN",
      "EGFR",
      "KRAS",
      "APC",
      "VHL"
    ],
    "layers": {
      "L1": {
        "nodes": 158,
        "edges": 3833
      },
      "L2": {
        "nodes": 196,
        "edges": 7668
      },
      "L3": {
        "nodes": 412,
        "edges": 342
      },
      "L4": {
        "nodes": 0,
        "edges": 0
      }
    },
    "l4_status": "BLOCKED (CELLxGENE SIGILL in sandbox) \u2014 empty, no fabricated data",
    "sources": [
      "STRING v12.0 (real)",
      "ClinVar esummary (real, dated)",
      "GTEx Portal API v2 (real)",
      "Gene Ontology (real, term-only, not gene-linked)"
    ],
    "panel_genes": [
      "AKT1",
      "ALK",
      "APC",
      "APOE",
      "APP",
      "AR",
      "ARID1A",
      "ASXL1",
      "ATM",
      "ATR",
      "ATRX",
      "AXIN2",
      "BAP1",
      "BARD1",
      "BAX",
      "BCL10",
      "BCL2",
      "BCL6",
      "BRAF",
      "BRCA1",
      "BRCA2",
      "BRIP1",
      "C9orf72",
      "CARD11",
      "CASP8",
      "CASR",
      "CBL",
      "CCND1",
      "CDH1",
      "CDK4",
      "CDK6",
      "CDKN2A",
      "CEBPA",
      "CFTR",
      "CHEK2",
      "CREBBP",
      "CTNNB1",
      "DAXX",
      "DMD",
      "DNMT3A",
      "EGFR",
      "EGLN1",
      "EP300",
      "EPAS1",
      "EPCAM",
      "ERBB2",
      "ERCC2",
      "ESR1",
      "EZH2",
      "FBXW7",
      "FH",
      "FLT1",
      "FLT3",
      "FMR1",
      "FOXA1",
      "FOXL2",
      "FUS",
      "G6PD",
      "GATA3",
      "GBA",
      "GLI1",
      "GNA11",
      "GNAQ",
      "GNAS",
      "GRN",
      "H3F3A",
      "HBB",
      "HIF1A",
      "HRAS",
      "HTT",
      "IDH1",
      "IDH2",
      "IDH3A",
      "JAK1",
      "JAK2",
      "KDM6A",
      "KDR",
      "KIT",
      "KMT2A",
      "KMT2D",
      "KRAS",
      "LDLR",
      "LRRK2",
      "LZTR1",
      "MAP2K1",
      "MAP2K2",
      "MAPT",
      "MDM2",
      "MDM4",
      "MEN1",
      "MET",
      "MLH1",
      "MSH2",
      "MSH3",
      "MSH6",
      "MTOR",
      "MYC",
      "MYD88",
      "NF1",
      "NF2",
      "NOTCH1",
      "NPM1",
      "NRAS",
      "PALB2",
      "PARK7",
      "PAX8",
      "PBRM1",
      "PCSK9",
      "PDGFRA",
      "PIK3CA",
      "PIK3R1",
      "PINK1",
      "PMS2",
      "POLD1",
      "POLE",
      "PRKAR1A",
      "PSEN1",
      "PSEN2",
      "PTCH1",
      "PTEN",
      "PTPN11",
      "RAD51C",
      "RAD51D",
      "RAF1",
      "RB1",
      "RET",
      "RUNX1",
      "SDHB",
      "SDHD",
      "SETD2",
      "SHOC2",
      "SMAD4",
      "SMARCB1",
      "SMN1",
      "SMO",
      "SNCA",
      "SOCS1",
      "SOD1",
      "SOS1",
      "SPRED1",
      "STAG2",
      "STAT3",
      "STK11",
      "SUFU",
      "TARDBP",
      "TERT",
      "TET2",
      "TNFAIP3",
      "TP53",
      "TP53BP1",
      "TSC1",
      "TSC2",
      "VEGFA",
      "VHL",
      "WT1",
      "XRCC1"
    ]
  }
}