---
license: other
license_name: venusrem2-academic
pretty_name: VenusREM2
---

# VenusREM2 data

Private archives for `rem2 download`. Layout is rem2 `--base_dir`
(`aa_seq/`, `substitutions/`, `pdbs/`, `aa_seq_aln_a2m_af2cf/`).
ProteinGym default MSA is the paper ColabFold set (`aa_seq_aln_a2m_af2cf.tar.gz`).
Assay lists match the Overleaf evaluation set: **1,211 assays**.

| Folder | Assays | Unique WT | Notes |
|--------|--------|-----------|--------|
| `ProteinGym/` | 217 | 187 (186 UniProt) | Official substitution DMS. 217 files per folder, same IDs as the paper panel. |
| `VenusMutHub/` | 905 | 527 | Same 905 assays as the paper macro-average. Duplicate-WT PDBs are assay-named copies or symlinks. |
| `VenusViroHub/` | 89 | 52 | Paper set after dropping `SARS2_XBB15_RBD_Taylor`. 616,690 evaluated substitutions (XnX kept in CSVs, excluded from metrics). Zero assay overlap with ProteinGym. |

VenusViroHub phenotype counts (paper Table): immune escape 21 / 148,468; cell entry 18 / 189,048; binding 17 / 90,245; expression 15 / 58,120; fitness 15 / 114,287; stability 2 / 11,187; activity 1 / 5,335.

Academic / non-profit use is free. Commercial or fee-for-service use requires a
license: contact tanyang.august@sjtu.edu.

Do not `git clone` this repo. Download the `.tar.gz` files and extract.