patient_id stringlengths 20 22 | cancer_type stringclasses 1
value | histology stringclasses 2
values | stage_at_diagnosis stringclasses 2
values | molecular_profile dict | baseline_clinical dict | disease_burden_at_dx dict | treatment_course dict | survival_outcomes dict | longitudinal_labs listlengths 3 3 |
|---|---|---|---|---|---|---|---|---|---|
ANODE_SYNTH_2025_10101 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 11.1,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 24
} | {
"age": 74,
"sex": "female",
"bmi": 29.5,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": [
"hypertension",
"COPD"
]
} | {
"primary_tumor_size_cm": 5.8,
"metastatic_sites": [
"pleura",
"brain"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2020-11-21T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -50,
"peak_response_20wk_change_percent": -62
},
"pfs_months": 20.6
},
"second_line_... | {
"overall_survival_months": 35.9,
"censored": false
} | [
{
"date": "2020-10-16T00:00:00",
"hemoglobin_g_dL": 15,
"wbc_k_uL": 5.3,
"platelets_k_uL": 331,
"creatinine_mg_dL": 0.61,
"alt_U_L": 17
},
{
"date": "2021-05-20T00:00:00",
"hemoglobin_g_dL": 14,
"wbc_k_uL": 5.7,
"platelets_k_uL": 157,
"creatinine_mg_dL": 1.53,
"al... |
ANODE_SYNTH_2025_10102 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 9.7,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 13
} | {
"age": 57,
"sex": "male",
"bmi": 29.8,
"smoking_pack_years": 36,
"ecog_performance_status": 1,
"comorbidities": [
"COPD"
]
} | {
"primary_tumor_size_cm": 6.4,
"metastatic_sites": [
"liver",
"brain",
"contralateral lung"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2021-09-09T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -30,
"peak_response_20wk_change_percent": -30
},
"pfs_months": 35.35
},
"second_line_th... | {
"overall_survival_months": 54.5,
"censored": false
} | [
{
"date": "2021-07-21T00:00:00",
"hemoglobin_g_dL": 14.8,
"wbc_k_uL": 10.2,
"platelets_k_uL": 269,
"creatinine_mg_dL": 0.98,
"alt_U_L": 66
},
{
"date": "2022-03-08T00:00:00",
"hemoglobin_g_dL": 10.2,
"wbc_k_uL": 6.1,
"platelets_k_uL": 202,
"creatinine_mg_dL": 0.99,
... |
ANODE_SYNTH_2025_10103 | Non-small cell lung cancer | Squamous cell carcinoma | IVB | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 10.9,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 31
} | {
"age": 69,
"sex": "male",
"bmi": 35.5,
"smoking_pack_years": 13,
"ecog_performance_status": 0,
"comorbidities": [
"hyperlipidemia"
]
} | {
"primary_tumor_size_cm": 4.3,
"metastatic_sites": [
"liver",
"bone"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2024-11-13T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -42,
"peak_response_20wk_change_percent": -69
},
"pfs_months": 26.97
... | {
"overall_survival_months": 45.8,
"censored": false
} | [
{
"date": "2024-10-21T00:00:00",
"hemoglobin_g_dL": 14.6,
"wbc_k_uL": 8.7,
"platelets_k_uL": 227,
"creatinine_mg_dL": 1.08,
"alt_U_L": 61
},
{
"date": "2025-05-12T00:00:00",
"hemoglobin_g_dL": 11.1,
"wbc_k_uL": 8.2,
"platelets_k_uL": 198,
"creatinine_mg_dL": 1.46,
... |
ANODE_SYNTH_2025_10104 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 13.3,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 3
} | {
"age": 69,
"sex": "female",
"bmi": 22.5,
"smoking_pack_years": 71,
"ecog_performance_status": 1,
"comorbidities": [
"diabetes"
]
} | {
"primary_tumor_size_cm": 3.2,
"metastatic_sites": [
"liver"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2024-01-27T00:00:00",
"best_response": "Stable disease",
"radiologic_response": {
"first_ct_8wk_change_percent": -26,
"peak_response_20wk_change_percent": -65
},
"pfs_months": 29.67
},
"second_line_ther... | {
"overall_survival_months": 53.7,
"censored": false
} | [
{
"date": "2024-01-07T00:00:00",
"hemoglobin_g_dL": 13.3,
"wbc_k_uL": 8,
"platelets_k_uL": 260,
"creatinine_mg_dL": 0.97,
"alt_U_L": 70
},
{
"date": "2024-07-25T00:00:00",
"hemoglobin_g_dL": 13,
"wbc_k_uL": 5.9,
"platelets_k_uL": 271,
"creatinine_mg_dL": 1.51,
"al... |
ANODE_SYNTH_2025_10105 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 9.1,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 3
} | {
"age": 58,
"sex": "male",
"bmi": 33.5,
"smoking_pack_years": 77,
"ecog_performance_status": 0,
"comorbidities": [
"COPD",
"diabetes"
]
} | {
"primary_tumor_size_cm": 5.6,
"metastatic_sites": [
"pleura"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2021-08-24T00:00:00",
"best_response": "Stable disease",
"radiologic_response": {
"first_ct_8wk_change_percent": -56,
"peak_response_20wk_change_percent": -60
},
"pfs_months": 42.84
},
"second_line_ther... | {
"overall_survival_months": 70.4,
"censored": false
} | [
{
"date": "2021-07-05T00:00:00",
"hemoglobin_g_dL": 13.7,
"wbc_k_uL": 5.3,
"platelets_k_uL": 315,
"creatinine_mg_dL": 1.07,
"alt_U_L": 64
},
{
"date": "2022-02-20T00:00:00",
"hemoglobin_g_dL": 12.8,
"wbc_k_uL": 4.7,
"platelets_k_uL": 253,
"creatinine_mg_dL": 1.53,
... |
ANODE_SYNTH_2025_10106 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 8.6,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 3
} | {
"age": 88,
"sex": "female",
"bmi": 20.7,
"smoking_pack_years": 34,
"ecog_performance_status": 0,
"comorbidities": [
"COPD"
]
} | {
"primary_tumor_size_cm": 3.4,
"metastatic_sites": [
"pleura"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2025-05-20T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -50,
"peak_response_20wk_change_percent": -40
},
"pfs_months": 9.23
},
"second_line_t... | {
"overall_survival_months": 29.2,
"censored": false
} | [
{
"date": "2025-04-04T00:00:00",
"hemoglobin_g_dL": 12.7,
"wbc_k_uL": 7.6,
"platelets_k_uL": 318,
"creatinine_mg_dL": 1.01,
"alt_U_L": 68
},
{
"date": "2025-11-16T00:00:00",
"hemoglobin_g_dL": 11,
"wbc_k_uL": 6.8,
"platelets_k_uL": 156,
"creatinine_mg_dL": 1.44,
"... |
ANODE_SYNTH_2025_10107 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 4.6,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 26
} | {
"age": 66,
"sex": "male",
"bmi": 19,
"smoking_pack_years": 13,
"ecog_performance_status": 1,
"comorbidities": [
"hyperlipidemia",
"hypertension"
]
} | {
"primary_tumor_size_cm": 4.9,
"metastatic_sites": [
"liver"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2020-09-06T00:00:00",
"best_response": "Stable disease",
"radiologic_response": {
"first_ct_8wk_change_percent": -48,
"peak_response_20wk_change_percent": -31
},
"pfs_months": 39.43
},
"second_line_ther... | {
"overall_survival_months": 58.7,
"censored": false
} | [
{
"date": "2020-07-25T00:00:00",
"hemoglobin_g_dL": 13,
"wbc_k_uL": 4.8,
"platelets_k_uL": 275,
"creatinine_mg_dL": 1.1,
"alt_U_L": 46
},
{
"date": "2021-03-05T00:00:00",
"hemoglobin_g_dL": 11.9,
"wbc_k_uL": 5.3,
"platelets_k_uL": 220,
"creatinine_mg_dL": 0.73,
"a... |
ANODE_SYNTH_2025_10108 | Non-small cell lung cancer | Squamous cell carcinoma | IV | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 7.3,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 10
} | {
"age": 66,
"sex": "male",
"bmi": 30.7,
"smoking_pack_years": 60,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 3.4,
"metastatic_sites": [
"liver"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2026-01-01T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -14,
"peak_response_20wk_change_percent": -74
},
"pfs_months": 22.31
... | {
"overall_survival_months": 36.2,
"censored": false
} | [
{
"date": "2025-11-25T00:00:00",
"hemoglobin_g_dL": 12.3,
"wbc_k_uL": 9.1,
"platelets_k_uL": 279,
"creatinine_mg_dL": 0.9,
"alt_U_L": 74
},
{
"date": "2026-06-30T00:00:00",
"hemoglobin_g_dL": 11,
"wbc_k_uL": 3.9,
"platelets_k_uL": 287,
"creatinine_mg_dL": 0.85,
"a... |
ANODE_SYNTH_2025_10109 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 4.8,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 17
} | {
"age": 55,
"sex": "female",
"bmi": 36.9,
"smoking_pack_years": 0,
"ecog_performance_status": 2,
"comorbidities": [
"hypertension",
"hyperlipidemia"
]
} | {
"primary_tumor_size_cm": 8,
"metastatic_sites": [
"liver",
"contralateral lung"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2025-10-09T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -32,
"peak_response_20wk_change_percent": -36
},
"pfs_months": 28.22
},
"second_line... | {
"overall_survival_months": 39.9,
"censored": false
} | [
{
"date": "2025-09-06T00:00:00",
"hemoglobin_g_dL": 12,
"wbc_k_uL": 10.5,
"platelets_k_uL": 445,
"creatinine_mg_dL": 0.79,
"alt_U_L": 66
},
{
"date": "2026-04-07T00:00:00",
"hemoglobin_g_dL": 14,
"wbc_k_uL": 8.7,
"platelets_k_uL": 258,
"creatinine_mg_dL": 1.28,
"a... |
ANODE_SYNTH_2025_10110 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 11.5,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 23
} | {
"age": 76,
"sex": "male",
"bmi": 23.6,
"smoking_pack_years": 48,
"ecog_performance_status": 1,
"comorbidities": [
"hypertension",
"diabetes"
]
} | {
"primary_tumor_size_cm": 5.8,
"metastatic_sites": [
"pleura"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2025-02-11T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -48,
"peak_response_20wk_change_percent": -42
},
"pfs_months": 15.31
},
"second_line_... | {
"overall_survival_months": 19.3,
"censored": true
} | [
{
"date": "2025-01-18T00:00:00",
"hemoglobin_g_dL": 13.5,
"wbc_k_uL": 8.6,
"platelets_k_uL": 344,
"creatinine_mg_dL": 0.65,
"alt_U_L": 10
},
{
"date": "2025-08-10T00:00:00",
"hemoglobin_g_dL": 12.2,
"wbc_k_uL": 4.7,
"platelets_k_uL": 270,
"creatinine_mg_dL": 1.45,
... |
ANODE_SYNTH_2025_10111 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 13.6,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 31
} | {
"age": 85,
"sex": "male",
"bmi": 27.8,
"smoking_pack_years": 79,
"ecog_performance_status": 0,
"comorbidities": [
"hyperlipidemia"
]
} | {
"primary_tumor_size_cm": 3.5,
"metastatic_sites": [
"brain",
"pleura"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2021-01-13T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -46,
"peak_response_20wk_change_percent": -43
},
"pfs_months": 30.95
},
"second_line_th... | {
"overall_survival_months": 49.3,
"censored": false
} | [
{
"date": "2020-11-10T00:00:00",
"hemoglobin_g_dL": 12.2,
"wbc_k_uL": 8.2,
"platelets_k_uL": 256,
"creatinine_mg_dL": 1.28,
"alt_U_L": 35
},
{
"date": "2021-07-12T00:00:00",
"hemoglobin_g_dL": 13.1,
"wbc_k_uL": 4.8,
"platelets_k_uL": 195,
"creatinine_mg_dL": 1.51,
... |
ANODE_SYNTH_2025_10112 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 17.9,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 34
} | {
"age": 68,
"sex": "male",
"bmi": 26,
"smoking_pack_years": 24,
"ecog_performance_status": 1,
"comorbidities": [
"COPD"
]
} | {
"primary_tumor_size_cm": 3.7,
"metastatic_sites": [
"brain",
"contralateral lung",
"liver"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2021-03-14T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -15,
"peak_response_20wk_change_percent": -34
},
"pfs_months": 20.07
},
"second_line_... | {
"overall_survival_months": 25.1,
"censored": false
} | [
{
"date": "2021-02-14T00:00:00",
"hemoglobin_g_dL": 14.9,
"wbc_k_uL": 5.9,
"platelets_k_uL": 173,
"creatinine_mg_dL": 0.78,
"alt_U_L": 58
},
{
"date": "2021-09-10T00:00:00",
"hemoglobin_g_dL": 11.1,
"wbc_k_uL": 5.1,
"platelets_k_uL": 196,
"creatinine_mg_dL": 0.83,
... |
ANODE_SYNTH_2025_10113 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 16,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 3
} | {
"age": 57,
"sex": "female",
"bmi": 31.2,
"smoking_pack_years": 50,
"ecog_performance_status": 0,
"comorbidities": [
"hyperlipidemia"
]
} | {
"primary_tumor_size_cm": 4,
"metastatic_sites": [
"contralateral lung",
"brain"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2021-08-28T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -46,
"peak_response_20wk_change_percent": -32
},
"pfs_months": 44.45
},
"second_line_th... | {
"overall_survival_months": 70,
"censored": false
} | [
{
"date": "2021-07-12T00:00:00",
"hemoglobin_g_dL": 12.2,
"wbc_k_uL": 5.3,
"platelets_k_uL": 302,
"creatinine_mg_dL": 1.12,
"alt_U_L": 56
},
{
"date": "2022-02-24T00:00:00",
"hemoglobin_g_dL": 10.9,
"wbc_k_uL": 6.6,
"platelets_k_uL": 279,
"creatinine_mg_dL": 0.91,
... |
ANODE_SYNTH_2025_10114 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 10.8,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 12
} | {
"age": 88,
"sex": "male",
"bmi": 22.4,
"smoking_pack_years": 49,
"ecog_performance_status": 1,
"comorbidities": [
"COPD"
]
} | {
"primary_tumor_size_cm": 5,
"metastatic_sites": [
"pleura",
"liver",
"contralateral lung"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2024-12-26T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -41,
"peak_response_20wk_change_percent": -84
},
"pfs_months": 24.28
},
"second_line_... | {
"overall_survival_months": 36.3,
"censored": false
} | [
{
"date": "2024-11-07T00:00:00",
"hemoglobin_g_dL": 14.8,
"wbc_k_uL": 4.6,
"platelets_k_uL": 388,
"creatinine_mg_dL": 0.78,
"alt_U_L": 20
},
{
"date": "2025-06-24T00:00:00",
"hemoglobin_g_dL": 13,
"wbc_k_uL": 3.8,
"platelets_k_uL": 256,
"creatinine_mg_dL": 1.38,
"... |
ANODE_SYNTH_2025_10115 | Non-small cell lung cancer | Squamous cell carcinoma | IVB | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 7.3,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 23
} | {
"age": 78,
"sex": "male",
"bmi": 23.8,
"smoking_pack_years": 70,
"ecog_performance_status": 1,
"comorbidities": [
"COPD"
]
} | {
"primary_tumor_size_cm": 7.3,
"metastatic_sites": [
"pleura"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2020-11-07T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -13,
"peak_response_20wk_change_percent": -44
},
"pfs_months": 25.79
... | {
"overall_survival_months": 41.1,
"censored": false
} | [
{
"date": "2020-10-13T00:00:00",
"hemoglobin_g_dL": 13.4,
"wbc_k_uL": 10.2,
"platelets_k_uL": 219,
"creatinine_mg_dL": 0.75,
"alt_U_L": 17
},
{
"date": "2021-05-06T00:00:00",
"hemoglobin_g_dL": 11.7,
"wbc_k_uL": 8.9,
"platelets_k_uL": 251,
"creatinine_mg_dL": 1.44,
... |
ANODE_SYNTH_2025_10116 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 13.3,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 3
} | {
"age": 75,
"sex": "female",
"bmi": 26,
"smoking_pack_years": 73,
"ecog_performance_status": 0,
"comorbidities": [
"hypertension",
"diabetes"
]
} | {
"primary_tumor_size_cm": 4,
"metastatic_sites": [
"pleura",
"brain"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2023-09-23T00:00:00",
"best_response": "Stable disease",
"radiologic_response": {
"first_ct_8wk_change_percent": -16,
"peak_response_20wk_change_percent": -32
},
"pfs_months": 10.58
},
"second_line_th... | {
"overall_survival_months": 20.4,
"censored": false
} | [
{
"date": "2023-09-07T00:00:00",
"hemoglobin_g_dL": 11.6,
"wbc_k_uL": 8.7,
"platelets_k_uL": 182,
"creatinine_mg_dL": 0.71,
"alt_U_L": 15
},
{
"date": "2024-03-21T00:00:00",
"hemoglobin_g_dL": 11.9,
"wbc_k_uL": 4.9,
"platelets_k_uL": 349,
"creatinine_mg_dL": 1.2,
... |
ANODE_SYNTH_2025_10117 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "EGFR L858R",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 4.8,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 11
} | {
"age": 85,
"sex": "female",
"bmi": 21.3,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": [
"diabetes"
]
} | {
"primary_tumor_size_cm": 3.8,
"metastatic_sites": [
"bone",
"liver",
"contralateral lung"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2021-01-18T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -38,
"peak_response_20wk_change_percent": -68
},
"pfs_months": 23.56
},
"second_line... | {
"overall_survival_months": 30.6,
"censored": false
} | [
{
"date": "2020-12-09T00:00:00",
"hemoglobin_g_dL": 12,
"wbc_k_uL": 4.9,
"platelets_k_uL": 194,
"creatinine_mg_dL": 0.66,
"alt_U_L": 57
},
{
"date": "2021-07-17T00:00:00",
"hemoglobin_g_dL": 11.4,
"wbc_k_uL": 7.2,
"platelets_k_uL": 126,
"creatinine_mg_dL": 0.94,
"... |
ANODE_SYNTH_2025_10118 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "NTRK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 2.6,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 11
} | {
"age": 64,
"sex": "female",
"bmi": 37,
"smoking_pack_years": 14,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 7.6,
"metastatic_sites": [
"brain"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "larotrectinib 100 mg BID",
"start_date": "2021-05-02T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -10,
"peak_response_20wk_change_percent": -76
},
"pfs_months": 25.66
},
"second_lin... | {
"overall_survival_months": 44.6,
"censored": false
} | [
{
"date": "2021-03-06T00:00:00",
"hemoglobin_g_dL": 13.6,
"wbc_k_uL": 9.5,
"platelets_k_uL": 351,
"creatinine_mg_dL": 1.13,
"alt_U_L": 29
},
{
"date": "2021-10-29T00:00:00",
"hemoglobin_g_dL": 11.9,
"wbc_k_uL": 5,
"platelets_k_uL": 370,
"creatinine_mg_dL": 1.45,
"... |
ANODE_SYNTH_2025_10119 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 6.9,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 23
} | {
"age": 76,
"sex": "male",
"bmi": 24.3,
"smoking_pack_years": 65,
"ecog_performance_status": 0,
"comorbidities": [
"hyperlipidemia",
"diabetes"
]
} | {
"primary_tumor_size_cm": 5.4,
"metastatic_sites": [
"contralateral lung"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2021-01-19T00:00:00",
"best_response": "Stable disease",
"radiologic_response": {
"first_ct_8wk_change_percent": -57,
"peak_response_20wk_change_percent": -80
},
"pfs_months": 35.02
},
"second_line_ther... | {
"overall_survival_months": 61.1,
"censored": true
} | [
{
"date": "2020-12-04T00:00:00",
"hemoglobin_g_dL": 12.9,
"wbc_k_uL": 10.3,
"platelets_k_uL": 169,
"creatinine_mg_dL": 1.25,
"alt_U_L": 80
},
{
"date": "2021-07-18T00:00:00",
"hemoglobin_g_dL": 13.6,
"wbc_k_uL": 5.5,
"platelets_k_uL": 288,
"creatinine_mg_dL": 1.28,
... |
ANODE_SYNTH_2025_10120 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 10.8,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 1
} | {
"age": 71,
"sex": "female",
"bmi": 22.8,
"smoking_pack_years": 41,
"ecog_performance_status": 1,
"comorbidities": [
"hypertension"
]
} | {
"primary_tumor_size_cm": 5.9,
"metastatic_sites": [
"bone",
"brain",
"contralateral lung"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2021-11-14T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -38,
"peak_response_20wk_change_percent": -44
},
"pfs_months": 38.67
},
"second_line_th... | {
"overall_survival_months": 64.8,
"censored": false
} | [
{
"date": "2021-09-22T00:00:00",
"hemoglobin_g_dL": 12.7,
"wbc_k_uL": 9.8,
"platelets_k_uL": 200,
"creatinine_mg_dL": 0.82,
"alt_U_L": 57
},
{
"date": "2022-05-13T00:00:00",
"hemoglobin_g_dL": 12,
"wbc_k_uL": 8.5,
"platelets_k_uL": 120,
"creatinine_mg_dL": 1.39,
"... |
ANODE_SYNTH_2025_10121 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 13.3,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 1
} | {
"age": 74,
"sex": "female",
"bmi": 21.8,
"smoking_pack_years": 69,
"ecog_performance_status": 2,
"comorbidities": [
"hyperlipidemia"
]
} | {
"primary_tumor_size_cm": 5.7,
"metastatic_sites": [
"bone"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2022-05-06T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -58,
"peak_response_20wk_change_percent": -47
},
"pfs_months": 7.66
},
"second_line_t... | {
"overall_survival_months": 18.1,
"censored": true
} | [
{
"date": "2022-03-07T00:00:00",
"hemoglobin_g_dL": 13.6,
"wbc_k_uL": 7.1,
"platelets_k_uL": 275,
"creatinine_mg_dL": 0.68,
"alt_U_L": 38
},
{
"date": "2022-11-02T00:00:00",
"hemoglobin_g_dL": 10.9,
"wbc_k_uL": 4.1,
"platelets_k_uL": 217,
"creatinine_mg_dL": 1.58,
... |
ANODE_SYNTH_2025_10122 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR L858R",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 15.1,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 13
} | {
"age": 84,
"sex": "female",
"bmi": 36.5,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": [
"diabetes",
"hypertension"
]
} | {
"primary_tumor_size_cm": 5.2,
"metastatic_sites": [
"liver",
"bone",
"brain"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2023-01-20T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -26,
"peak_response_20wk_change_percent": -85
},
"pfs_months": 24.51
},
"second_line... | {
"overall_survival_months": 37.4,
"censored": false
} | [
{
"date": "2022-12-10T00:00:00",
"hemoglobin_g_dL": 14.9,
"wbc_k_uL": 10.1,
"platelets_k_uL": 183,
"creatinine_mg_dL": 1.09,
"alt_U_L": 21
},
{
"date": "2023-07-19T00:00:00",
"hemoglobin_g_dL": 13.6,
"wbc_k_uL": 8,
"platelets_k_uL": 243,
"creatinine_mg_dL": 1.25,
... |
ANODE_SYNTH_2025_10123 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 6.5,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 14
} | {
"age": 83,
"sex": "male",
"bmi": 25.5,
"smoking_pack_years": 15,
"ecog_performance_status": 0,
"comorbidities": [
"diabetes"
]
} | {
"primary_tumor_size_cm": 5.1,
"metastatic_sites": [
"brain",
"pleura"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2025-02-28T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -13,
"peak_response_20wk_change_percent": -50
},
"pfs_months": 6.7
},
"second_line_th... | {
"overall_survival_months": 15.1,
"censored": false
} | [
{
"date": "2024-12-21T00:00:00",
"hemoglobin_g_dL": 13.9,
"wbc_k_uL": 6.4,
"platelets_k_uL": 219,
"creatinine_mg_dL": 1.11,
"alt_U_L": 46
},
{
"date": "2025-08-27T00:00:00",
"hemoglobin_g_dL": 12.3,
"wbc_k_uL": 6.6,
"platelets_k_uL": 248,
"creatinine_mg_dL": 1.13,
... |
ANODE_SYNTH_2025_10124 | Non-small cell lung cancer | Squamous cell carcinoma | IVB | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 4.9,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 22
} | {
"age": 55,
"sex": "female",
"bmi": 20.5,
"smoking_pack_years": 54,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 4.6,
"metastatic_sites": [
"liver"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2025-05-01T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -32,
"peak_response_20wk_change_percent": -73
},
"pfs_months": 7.85
}... | {
"overall_survival_months": 15.6,
"censored": false
} | [
{
"date": "2025-04-02T00:00:00",
"hemoglobin_g_dL": 12.6,
"wbc_k_uL": 8.8,
"platelets_k_uL": 287,
"creatinine_mg_dL": 0.93,
"alt_U_L": 60
},
{
"date": "2025-10-28T00:00:00",
"hemoglobin_g_dL": 13.8,
"wbc_k_uL": 4.8,
"platelets_k_uL": 217,
"creatinine_mg_dL": 1,
"a... |
ANODE_SYNTH_2025_10125 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 10.7,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 19
} | {
"age": 88,
"sex": "female",
"bmi": 25,
"smoking_pack_years": 52,
"ecog_performance_status": 2,
"comorbidities": [
"COPD",
"hypertension"
]
} | {
"primary_tumor_size_cm": 4.1,
"metastatic_sites": [
"liver"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2020-10-18T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -13,
"peak_response_20wk_change_percent": -71
},
"pfs_months": 41.17
},
"second_line_th... | {
"overall_survival_months": 68.8,
"censored": false
} | [
{
"date": "2020-08-23T00:00:00",
"hemoglobin_g_dL": 15.2,
"wbc_k_uL": 10.6,
"platelets_k_uL": 218,
"creatinine_mg_dL": 1.01,
"alt_U_L": 18
},
{
"date": "2021-04-16T00:00:00",
"hemoglobin_g_dL": 13.4,
"wbc_k_uL": 7.2,
"platelets_k_uL": 177,
"creatinine_mg_dL": 1.1,
... |
ANODE_SYNTH_2025_10126 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 10.6,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 18
} | {
"age": 65,
"sex": "male",
"bmi": 31.9,
"smoking_pack_years": 42,
"ecog_performance_status": 1,
"comorbidities": [
"hypertension"
]
} | {
"primary_tumor_size_cm": 3.7,
"metastatic_sites": [
"contralateral lung"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2022-12-31T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -42,
"peak_response_20wk_change_percent": -47
},
"pfs_months": 31.31
},
"second_line_th... | {
"overall_survival_months": 46.8,
"censored": false
} | [
{
"date": "2022-12-09T00:00:00",
"hemoglobin_g_dL": 12.3,
"wbc_k_uL": 7.5,
"platelets_k_uL": 388,
"creatinine_mg_dL": 1.02,
"alt_U_L": 57
},
{
"date": "2023-06-29T00:00:00",
"hemoglobin_g_dL": 13.8,
"wbc_k_uL": 7.6,
"platelets_k_uL": 179,
"creatinine_mg_dL": 1.15,
... |
ANODE_SYNTH_2025_10127 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "NTRK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 17.5,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 19
} | {
"age": 51,
"sex": "male",
"bmi": 30.9,
"smoking_pack_years": 20,
"ecog_performance_status": 1,
"comorbidities": [
"diabetes"
]
} | {
"primary_tumor_size_cm": 6.7,
"metastatic_sites": [
"bone"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "larotrectinib 100 mg BID",
"start_date": "2024-03-28T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -41,
"peak_response_20wk_change_percent": -77
},
"pfs_months": 18.86
},
"second_lin... | {
"overall_survival_months": 31.7,
"censored": true
} | [
{
"date": "2024-02-16T00:00:00",
"hemoglobin_g_dL": 12.9,
"wbc_k_uL": 9.8,
"platelets_k_uL": 222,
"creatinine_mg_dL": 1.27,
"alt_U_L": 45
},
{
"date": "2024-09-24T00:00:00",
"hemoglobin_g_dL": 12.5,
"wbc_k_uL": 5.5,
"platelets_k_uL": 194,
"creatinine_mg_dL": 0.89,
... |
ANODE_SYNTH_2025_10128 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 8.1,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 32
} | {
"age": 74,
"sex": "female",
"bmi": 35.2,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": [
"COPD",
"hypertension"
]
} | {
"primary_tumor_size_cm": 3.4,
"metastatic_sites": [
"brain",
"bone",
"contralateral lung"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2020-03-05T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -59,
"peak_response_20wk_change_percent": -48
},
"pfs_months": 18.2
},
"second_line_... | {
"overall_survival_months": 33.1,
"censored": false
} | [
{
"date": "2020-02-06T00:00:00",
"hemoglobin_g_dL": 11.8,
"wbc_k_uL": 4.8,
"platelets_k_uL": 296,
"creatinine_mg_dL": 1.01,
"alt_U_L": 75
},
{
"date": "2020-09-01T00:00:00",
"hemoglobin_g_dL": 12.1,
"wbc_k_uL": 5.2,
"platelets_k_uL": 256,
"creatinine_mg_dL": 0.99,
... |
ANODE_SYNTH_2025_10129 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 10.3,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 10
} | {
"age": 70,
"sex": "female",
"bmi": 33.3,
"smoking_pack_years": 0,
"ecog_performance_status": 0,
"comorbidities": []
} | {
"primary_tumor_size_cm": 7.1,
"metastatic_sites": [
"contralateral lung",
"brain",
"liver"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2021-08-29T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -28,
"peak_response_20wk_change_percent": -60
},
"pfs_months": 21.75
},
"second_line... | {
"overall_survival_months": 29.8,
"censored": true
} | [
{
"date": "2021-08-14T00:00:00",
"hemoglobin_g_dL": 13.2,
"wbc_k_uL": 7.8,
"platelets_k_uL": 383,
"creatinine_mg_dL": 0.77,
"alt_U_L": 53
},
{
"date": "2022-02-25T00:00:00",
"hemoglobin_g_dL": 11.5,
"wbc_k_uL": 7.5,
"platelets_k_uL": 344,
"creatinine_mg_dL": 0.78,
... |
ANODE_SYNTH_2025_10130 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR L858R",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 2.8,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 34
} | {
"age": 74,
"sex": "female",
"bmi": 33.1,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": [
"hypertension",
"diabetes"
]
} | {
"primary_tumor_size_cm": 7.9,
"metastatic_sites": [
"liver",
"contralateral lung"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2020-07-16T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -35,
"peak_response_20wk_change_percent": -67
},
"pfs_months": 20.83
},
"second_line... | {
"overall_survival_months": 35.1,
"censored": false
} | [
{
"date": "2020-06-14T00:00:00",
"hemoglobin_g_dL": 14.1,
"wbc_k_uL": 4.7,
"platelets_k_uL": 245,
"creatinine_mg_dL": 1.1,
"alt_U_L": 64
},
{
"date": "2021-01-12T00:00:00",
"hemoglobin_g_dL": 11.4,
"wbc_k_uL": 5.6,
"platelets_k_uL": 351,
"creatinine_mg_dL": 1.53,
... |
ANODE_SYNTH_2025_10131 | Non-small cell lung cancer | Squamous cell carcinoma | IV | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 16.7,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 27
} | {
"age": 55,
"sex": "female",
"bmi": 29.8,
"smoking_pack_years": 21,
"ecog_performance_status": 1,
"comorbidities": [
"COPD"
]
} | {
"primary_tumor_size_cm": 8.4,
"metastatic_sites": [
"brain",
"liver",
"contralateral lung"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2020-09-14T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -52,
"peak_response_20wk_change_percent": -68
},
"pfs_months": 27.3
}... | {
"overall_survival_months": 43.3,
"censored": false
} | [
{
"date": "2020-07-20T00:00:00",
"hemoglobin_g_dL": 12.5,
"wbc_k_uL": 10.7,
"platelets_k_uL": 217,
"creatinine_mg_dL": 0.7,
"alt_U_L": 57
},
{
"date": "2021-03-13T00:00:00",
"hemoglobin_g_dL": 10.2,
"wbc_k_uL": 4.9,
"platelets_k_uL": 270,
"creatinine_mg_dL": 0.87,
... |
ANODE_SYNTH_2025_10132 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 3.8,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 23
} | {
"age": 72,
"sex": "female",
"bmi": 28.6,
"smoking_pack_years": 21,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 4.8,
"metastatic_sites": [
"brain",
"liver",
"bone"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2021-09-18T00:00:00",
"best_response": "Stable disease",
"radiologic_response": {
"first_ct_8wk_change_percent": -49,
"peak_response_20wk_change_percent": -68
},
"pfs_months": 39.23
},
"second_line_ther... | {
"overall_survival_months": 67.1,
"censored": true
} | [
{
"date": "2021-07-23T00:00:00",
"hemoglobin_g_dL": 12,
"wbc_k_uL": 9,
"platelets_k_uL": 372,
"creatinine_mg_dL": 0.95,
"alt_U_L": 68
},
{
"date": "2022-03-17T00:00:00",
"hemoglobin_g_dL": 14,
"wbc_k_uL": 6.8,
"platelets_k_uL": 215,
"creatinine_mg_dL": 1.2,
"alt_U... |
ANODE_SYNTH_2025_10133 | Non-small cell lung cancer | Squamous cell carcinoma | IVB | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 13.6,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 5
} | {
"age": 83,
"sex": "female",
"bmi": 26.2,
"smoking_pack_years": 65,
"ecog_performance_status": 1,
"comorbidities": [
"hyperlipidemia",
"hypertension"
]
} | {
"primary_tumor_size_cm": 8.1,
"metastatic_sites": [
"pleura"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2020-11-13T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -48,
"peak_response_20wk_change_percent": -70
},
"pfs_months": 17.38
... | {
"overall_survival_months": 29.7,
"censored": true
} | [
{
"date": "2020-09-06T00:00:00",
"hemoglobin_g_dL": 13,
"wbc_k_uL": 8.6,
"platelets_k_uL": 213,
"creatinine_mg_dL": 0.86,
"alt_U_L": 72
},
{
"date": "2021-05-12T00:00:00",
"hemoglobin_g_dL": 14,
"wbc_k_uL": 7.2,
"platelets_k_uL": 207,
"creatinine_mg_dL": 0.93,
"al... |
ANODE_SYNTH_2025_10134 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 16.9,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 29
} | {
"age": 86,
"sex": "female",
"bmi": 29.4,
"smoking_pack_years": 41,
"ecog_performance_status": 0,
"comorbidities": []
} | {
"primary_tumor_size_cm": 3.2,
"metastatic_sites": [
"brain",
"contralateral lung",
"liver"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2025-05-27T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -22,
"peak_response_20wk_change_percent": -47
},
"pfs_months": 25.49
},
"second_line_th... | {
"overall_survival_months": 40.4,
"censored": true
} | [
{
"date": "2025-04-12T00:00:00",
"hemoglobin_g_dL": 11.7,
"wbc_k_uL": 8.2,
"platelets_k_uL": 326,
"creatinine_mg_dL": 0.86,
"alt_U_L": 77
},
{
"date": "2025-11-23T00:00:00",
"hemoglobin_g_dL": 11.5,
"wbc_k_uL": 5,
"platelets_k_uL": 196,
"creatinine_mg_dL": 0.86,
"... |
ANODE_SYNTH_2025_10135 | Non-small cell lung cancer | Squamous cell carcinoma | IV | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 14.5,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 6
} | {
"age": 88,
"sex": "female",
"bmi": 36.3,
"smoking_pack_years": 46,
"ecog_performance_status": 1,
"comorbidities": [
"COPD"
]
} | {
"primary_tumor_size_cm": 6.7,
"metastatic_sites": [
"liver"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2024-10-27T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -57,
"peak_response_20wk_change_percent": -66
},
"pfs_months": 27.99
... | {
"overall_survival_months": 38.8,
"censored": false
} | [
{
"date": "2024-10-06T00:00:00",
"hemoglobin_g_dL": 14.9,
"wbc_k_uL": 10.8,
"platelets_k_uL": 336,
"creatinine_mg_dL": 0.7,
"alt_U_L": 45
},
{
"date": "2025-04-25T00:00:00",
"hemoglobin_g_dL": 12.8,
"wbc_k_uL": 5.9,
"platelets_k_uL": 326,
"creatinine_mg_dL": 1.47,
... |
ANODE_SYNTH_2025_10136 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 6.5,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 25
} | {
"age": 56,
"sex": "male",
"bmi": 34,
"smoking_pack_years": 53,
"ecog_performance_status": 2,
"comorbidities": [
"hypertension"
]
} | {
"primary_tumor_size_cm": 5.8,
"metastatic_sites": [
"pleura",
"contralateral lung"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2024-04-16T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -51,
"peak_response_20wk_change_percent": -61
},
"pfs_months": 10.68
},
"second_line_... | {
"overall_survival_months": 17,
"censored": false
} | [
{
"date": "2024-02-28T00:00:00",
"hemoglobin_g_dL": 15.3,
"wbc_k_uL": 10.6,
"platelets_k_uL": 246,
"creatinine_mg_dL": 0.88,
"alt_U_L": 27
},
{
"date": "2024-10-13T00:00:00",
"hemoglobin_g_dL": 13.1,
"wbc_k_uL": 6.8,
"platelets_k_uL": 314,
"creatinine_mg_dL": 0.99,
... |
ANODE_SYNTH_2025_10137 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 12.2,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 20
} | {
"age": 50,
"sex": "female",
"bmi": 25.6,
"smoking_pack_years": 33,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 4,
"metastatic_sites": [
"liver",
"contralateral lung",
"pleura"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2021-07-21T00:00:00",
"best_response": "Stable disease",
"radiologic_response": {
"first_ct_8wk_change_percent": -25,
"peak_response_20wk_change_percent": -40
},
"pfs_months": 30.52
},
"second_line_ther... | {
"overall_survival_months": 54.9,
"censored": true
} | [
{
"date": "2021-05-17T00:00:00",
"hemoglobin_g_dL": 14.3,
"wbc_k_uL": 6.1,
"platelets_k_uL": 405,
"creatinine_mg_dL": 1.16,
"alt_U_L": 19
},
{
"date": "2022-01-17T00:00:00",
"hemoglobin_g_dL": 10.2,
"wbc_k_uL": 5,
"platelets_k_uL": 247,
"creatinine_mg_dL": 0.87,
"... |
ANODE_SYNTH_2025_10138 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR L858R",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 2.7,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 9
} | {
"age": 53,
"sex": "female",
"bmi": 21.5,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": [
"hyperlipidemia"
]
} | {
"primary_tumor_size_cm": 5.4,
"metastatic_sites": [
"contralateral lung",
"pleura",
"brain"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2023-01-18T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -24,
"peak_response_20wk_change_percent": -56
},
"pfs_months": 17.18
},
"second_line... | {
"overall_survival_months": 25.7,
"censored": false
} | [
{
"date": "2022-12-02T00:00:00",
"hemoglobin_g_dL": 12.2,
"wbc_k_uL": 4.9,
"platelets_k_uL": 351,
"creatinine_mg_dL": 1.01,
"alt_U_L": 51
},
{
"date": "2023-07-17T00:00:00",
"hemoglobin_g_dL": 10.2,
"wbc_k_uL": 6.9,
"platelets_k_uL": 150,
"creatinine_mg_dL": 1.15,
... |
ANODE_SYNTH_2025_10139 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR L858R",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 11.1,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 15
} | {
"age": 56,
"sex": "female",
"bmi": 22.5,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": [
"hyperlipidemia",
"hypertension"
]
} | {
"primary_tumor_size_cm": 4.7,
"metastatic_sites": [
"bone",
"pleura"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2022-11-07T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -42,
"peak_response_20wk_change_percent": -45
},
"pfs_months": 17.18
},
"second_line... | {
"overall_survival_months": 37.1,
"censored": true
} | [
{
"date": "2022-09-03T00:00:00",
"hemoglobin_g_dL": 12.7,
"wbc_k_uL": 8.8,
"platelets_k_uL": 369,
"creatinine_mg_dL": 0.9,
"alt_U_L": 58
},
{
"date": "2023-05-06T00:00:00",
"hemoglobin_g_dL": 10.4,
"wbc_k_uL": 6.1,
"platelets_k_uL": 177,
"creatinine_mg_dL": 1.43,
... |
ANODE_SYNTH_2025_10140 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 12.3,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 30
} | {
"age": 51,
"sex": "female",
"bmi": 24.8,
"smoking_pack_years": 0,
"ecog_performance_status": 0,
"comorbidities": [
"hypertension",
"COPD"
]
} | {
"primary_tumor_size_cm": 5.3,
"metastatic_sites": [
"brain",
"pleura",
"bone"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2022-05-10T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -33,
"peak_response_20wk_change_percent": -74
},
"pfs_months": 20.57
},
"second_line... | {
"overall_survival_months": 36.3,
"censored": false
} | [
{
"date": "2022-03-17T00:00:00",
"hemoglobin_g_dL": 12.8,
"wbc_k_uL": 8.6,
"platelets_k_uL": 369,
"creatinine_mg_dL": 1.11,
"alt_U_L": 12
},
{
"date": "2022-11-06T00:00:00",
"hemoglobin_g_dL": 13.2,
"wbc_k_uL": 6.6,
"platelets_k_uL": 150,
"creatinine_mg_dL": 1.5,
... |
ANODE_SYNTH_2025_10141 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 3.7,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 30
} | {
"age": 48,
"sex": "female",
"bmi": 20.7,
"smoking_pack_years": 56,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 7.1,
"metastatic_sites": [
"contralateral lung",
"bone",
"pleura"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2022-04-15T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -42,
"peak_response_20wk_change_percent": -74
},
"pfs_months": 26.09
},
"second_line_th... | {
"overall_survival_months": 47.9,
"censored": false
} | [
{
"date": "2022-02-26T00:00:00",
"hemoglobin_g_dL": 13.6,
"wbc_k_uL": 5.5,
"platelets_k_uL": 341,
"creatinine_mg_dL": 0.82,
"alt_U_L": 16
},
{
"date": "2022-10-12T00:00:00",
"hemoglobin_g_dL": 13.5,
"wbc_k_uL": 5.5,
"platelets_k_uL": 291,
"creatinine_mg_dL": 0.71,
... |
ANODE_SYNTH_2025_10142 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 11.7,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 27
} | {
"age": 62,
"sex": "male",
"bmi": 26.2,
"smoking_pack_years": 14,
"ecog_performance_status": 0,
"comorbidities": []
} | {
"primary_tumor_size_cm": 3.1,
"metastatic_sites": [
"brain",
"contralateral lung",
"liver"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2022-05-03T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -52,
"peak_response_20wk_change_percent": -82
},
"pfs_months": 37.39
},
"second_line_th... | {
"overall_survival_months": 67.2,
"censored": true
} | [
{
"date": "2022-04-18T00:00:00",
"hemoglobin_g_dL": 13.5,
"wbc_k_uL": 9.4,
"platelets_k_uL": 418,
"creatinine_mg_dL": 0.71,
"alt_U_L": 68
},
{
"date": "2022-10-30T00:00:00",
"hemoglobin_g_dL": 12.1,
"wbc_k_uL": 7.9,
"platelets_k_uL": 345,
"creatinine_mg_dL": 1.39,
... |
ANODE_SYNTH_2025_10143 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "NTRK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 15.3,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 11
} | {
"age": 74,
"sex": "female",
"bmi": 23.4,
"smoking_pack_years": 76,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 3.9,
"metastatic_sites": [
"bone"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "larotrectinib 100 mg BID",
"start_date": "2020-10-10T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -53,
"peak_response_20wk_change_percent": -40
},
"pfs_months": 34.89
},
"second_lin... | {
"overall_survival_months": 68.9,
"censored": false
} | [
{
"date": "2020-08-10T00:00:00",
"hemoglobin_g_dL": 14.2,
"wbc_k_uL": 10.4,
"platelets_k_uL": 269,
"creatinine_mg_dL": 0.84,
"alt_U_L": 33
},
{
"date": "2021-04-08T00:00:00",
"hemoglobin_g_dL": 11.4,
"wbc_k_uL": 4.7,
"platelets_k_uL": 219,
"creatinine_mg_dL": 0.78,
... |
ANODE_SYNTH_2025_10144 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 3.2,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 19
} | {
"age": 61,
"sex": "male",
"bmi": 32.4,
"smoking_pack_years": 68,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 4.8,
"metastatic_sites": [
"bone"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2021-01-31T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -28,
"peak_response_20wk_change_percent": -81
},
"pfs_months": 31.01
},
"second_line_th... | {
"overall_survival_months": 53,
"censored": false
} | [
{
"date": "2021-01-12T00:00:00",
"hemoglobin_g_dL": 11.7,
"wbc_k_uL": 7.4,
"platelets_k_uL": 413,
"creatinine_mg_dL": 1.24,
"alt_U_L": 44
},
{
"date": "2021-07-30T00:00:00",
"hemoglobin_g_dL": 10.5,
"wbc_k_uL": 5,
"platelets_k_uL": 175,
"creatinine_mg_dL": 1.35,
"... |
ANODE_SYNTH_2025_10145 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "EGFR L858R",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 17.4,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 32
} | {
"age": 51,
"sex": "female",
"bmi": 24.7,
"smoking_pack_years": 0,
"ecog_performance_status": 0,
"comorbidities": [
"COPD"
]
} | {
"primary_tumor_size_cm": 3.9,
"metastatic_sites": [
"contralateral lung",
"bone"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2023-04-24T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -43,
"peak_response_20wk_change_percent": -36
},
"pfs_months": 18.3
},
"second_line_... | {
"overall_survival_months": 37.2,
"censored": true
} | [
{
"date": "2023-02-23T00:00:00",
"hemoglobin_g_dL": 12.8,
"wbc_k_uL": 5,
"platelets_k_uL": 188,
"creatinine_mg_dL": 0.85,
"alt_U_L": 54
},
{
"date": "2023-10-21T00:00:00",
"hemoglobin_g_dL": 10.5,
"wbc_k_uL": 8.9,
"platelets_k_uL": 300,
"creatinine_mg_dL": 1.25,
"... |
ANODE_SYNTH_2025_10146 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 4.7,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 28
} | {
"age": 53,
"sex": "female",
"bmi": 29.6,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": [
"COPD"
]
} | {
"primary_tumor_size_cm": 7.9,
"metastatic_sites": [
"brain",
"pleura",
"liver"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2020-12-02T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -35,
"peak_response_20wk_change_percent": -50
},
"pfs_months": 10.94
},
"second_line... | {
"overall_survival_months": 18.4,
"censored": false
} | [
{
"date": "2020-09-27T00:00:00",
"hemoglobin_g_dL": 14.8,
"wbc_k_uL": 10.8,
"platelets_k_uL": 273,
"creatinine_mg_dL": 0.77,
"alt_U_L": 70
},
{
"date": "2021-05-31T00:00:00",
"hemoglobin_g_dL": 11.2,
"wbc_k_uL": 7,
"platelets_k_uL": 179,
"creatinine_mg_dL": 1.55,
... |
ANODE_SYNTH_2025_10147 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 12.2,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 18
} | {
"age": 65,
"sex": "female",
"bmi": 31.8,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": [
"hypertension",
"diabetes"
]
} | {
"primary_tumor_size_cm": 3.4,
"metastatic_sites": [
"contralateral lung"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2025-02-21T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -18,
"peak_response_20wk_change_percent": -53
},
"pfs_months": 25.33
},
"second_line... | {
"overall_survival_months": 46.3,
"censored": false
} | [
{
"date": "2025-02-01T00:00:00",
"hemoglobin_g_dL": 13.7,
"wbc_k_uL": 6.2,
"platelets_k_uL": 272,
"creatinine_mg_dL": 0.99,
"alt_U_L": 45
},
{
"date": "2025-08-20T00:00:00",
"hemoglobin_g_dL": 10.3,
"wbc_k_uL": 4.5,
"platelets_k_uL": 263,
"creatinine_mg_dL": 1.39,
... |
ANODE_SYNTH_2025_10148 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 3.9,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 5
} | {
"age": 55,
"sex": "male",
"bmi": 22.5,
"smoking_pack_years": 74,
"ecog_performance_status": 1,
"comorbidities": [
"hypertension",
"diabetes"
]
} | {
"primary_tumor_size_cm": 8.4,
"metastatic_sites": [
"contralateral lung",
"brain",
"liver"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2021-05-19T00:00:00",
"best_response": "Stable disease",
"radiologic_response": {
"first_ct_8wk_change_percent": -14,
"peak_response_20wk_change_percent": -43
},
"pfs_months": 8.64
},
"second_line_the... | {
"overall_survival_months": 12.6,
"censored": false
} | [
{
"date": "2021-03-10T00:00:00",
"hemoglobin_g_dL": 15.1,
"wbc_k_uL": 8,
"platelets_k_uL": 151,
"creatinine_mg_dL": 1.27,
"alt_U_L": 47
},
{
"date": "2021-11-15T00:00:00",
"hemoglobin_g_dL": 13.6,
"wbc_k_uL": 8,
"platelets_k_uL": 124,
"creatinine_mg_dL": 0.77,
"al... |
ANODE_SYNTH_2025_10149 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 13.9,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 3
} | {
"age": 74,
"sex": "female",
"bmi": 34.8,
"smoking_pack_years": 0,
"ecog_performance_status": 0,
"comorbidities": [
"hypertension",
"diabetes"
]
} | {
"primary_tumor_size_cm": 7.6,
"metastatic_sites": [
"liver",
"contralateral lung",
"bone"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2025-08-10T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -58,
"peak_response_20wk_change_percent": -30
},
"pfs_months": 27.6
},
"second_line_... | {
"overall_survival_months": 33.6,
"censored": false
} | [
{
"date": "2025-07-26T00:00:00",
"hemoglobin_g_dL": 11.5,
"wbc_k_uL": 5.1,
"platelets_k_uL": 409,
"creatinine_mg_dL": 1.26,
"alt_U_L": 46
},
{
"date": "2026-02-06T00:00:00",
"hemoglobin_g_dL": 10.8,
"wbc_k_uL": 6,
"platelets_k_uL": 214,
"creatinine_mg_dL": 1.01,
"... |
ANODE_SYNTH_2025_10150 | Non-small cell lung cancer | Squamous cell carcinoma | IVB | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 17.3,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 8
} | {
"age": 78,
"sex": "female",
"bmi": 27.1,
"smoking_pack_years": 55,
"ecog_performance_status": 1,
"comorbidities": [
"hyperlipidemia"
]
} | {
"primary_tumor_size_cm": 8.4,
"metastatic_sites": [
"bone",
"brain",
"liver"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2025-07-29T00:00:00",
"best_response": "Stable disease",
"radiologic_response": {
"first_ct_8wk_change_percent": -43,
"peak_response_20wk_change_percent": -72
},
"pfs_months": 19.22
},... | {
"overall_survival_months": 35.2,
"censored": true
} | [
{
"date": "2025-07-07T00:00:00",
"hemoglobin_g_dL": 15.2,
"wbc_k_uL": 5.7,
"platelets_k_uL": 431,
"creatinine_mg_dL": 1.17,
"alt_U_L": 46
},
{
"date": "2026-01-25T00:00:00",
"hemoglobin_g_dL": 10.2,
"wbc_k_uL": 8.6,
"platelets_k_uL": 202,
"creatinine_mg_dL": 1.4,
... |
ANODE_SYNTH_2025_10151 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 12,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 29
} | {
"age": 84,
"sex": "female",
"bmi": 36,
"smoking_pack_years": 71,
"ecog_performance_status": 1,
"comorbidities": [
"COPD",
"hypertension"
]
} | {
"primary_tumor_size_cm": 7.5,
"metastatic_sites": [
"bone",
"brain"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2020-08-22T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -42,
"peak_response_20wk_change_percent": -36
},
"pfs_months": 5.29
},
"second_line_t... | {
"overall_survival_months": 19.2,
"censored": false
} | [
{
"date": "2020-07-11T00:00:00",
"hemoglobin_g_dL": 12.1,
"wbc_k_uL": 9.1,
"platelets_k_uL": 293,
"creatinine_mg_dL": 1.24,
"alt_U_L": 41
},
{
"date": "2021-02-18T00:00:00",
"hemoglobin_g_dL": 10.6,
"wbc_k_uL": 8,
"platelets_k_uL": 290,
"creatinine_mg_dL": 0.77,
"... |
ANODE_SYNTH_2025_10152 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR L858R",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 9.5,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 15
} | {
"age": 61,
"sex": "female",
"bmi": 26.5,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 7.6,
"metastatic_sites": [
"brain",
"bone"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2020-10-17T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -17,
"peak_response_20wk_change_percent": -30
},
"pfs_months": 21.88
},
"second_line... | {
"overall_survival_months": 45.6,
"censored": false
} | [
{
"date": "2020-09-08T00:00:00",
"hemoglobin_g_dL": 13.5,
"wbc_k_uL": 9,
"platelets_k_uL": 365,
"creatinine_mg_dL": 0.69,
"alt_U_L": 67
},
{
"date": "2021-04-15T00:00:00",
"hemoglobin_g_dL": 13.2,
"wbc_k_uL": 3.9,
"platelets_k_uL": 307,
"creatinine_mg_dL": 1.59,
"... |
ANODE_SYNTH_2025_10153 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 10.7,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 33
} | {
"age": 84,
"sex": "female",
"bmi": 27.7,
"smoking_pack_years": 0,
"ecog_performance_status": 0,
"comorbidities": [
"diabetes"
]
} | {
"primary_tumor_size_cm": 3.2,
"metastatic_sites": [
"pleura",
"brain",
"liver"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2024-12-28T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -56,
"peak_response_20wk_change_percent": -65
},
"pfs_months": 27.27
},
"second_line... | {
"overall_survival_months": 35.8,
"censored": false
} | [
{
"date": "2024-10-28T00:00:00",
"hemoglobin_g_dL": 12.3,
"wbc_k_uL": 8.6,
"platelets_k_uL": 298,
"creatinine_mg_dL": 0.98,
"alt_U_L": 27
},
{
"date": "2025-06-26T00:00:00",
"hemoglobin_g_dL": 13.8,
"wbc_k_uL": 4.5,
"platelets_k_uL": 247,
"creatinine_mg_dL": 1.09,
... |
ANODE_SYNTH_2025_10154 | Non-small cell lung cancer | Squamous cell carcinoma | IV | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 18,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 1
} | {
"age": 65,
"sex": "female",
"bmi": 31.2,
"smoking_pack_years": 52,
"ecog_performance_status": 1,
"comorbidities": [
"diabetes"
]
} | {
"primary_tumor_size_cm": 7,
"metastatic_sites": [
"contralateral lung"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2021-08-03T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -58,
"peak_response_20wk_change_percent": -44
},
"pfs_months": 19.35
... | {
"overall_survival_months": 37.9,
"censored": false
} | [
{
"date": "2021-06-01T00:00:00",
"hemoglobin_g_dL": 13.3,
"wbc_k_uL": 10.6,
"platelets_k_uL": 337,
"creatinine_mg_dL": 0.69,
"alt_U_L": 68
},
{
"date": "2022-01-30T00:00:00",
"hemoglobin_g_dL": 12.2,
"wbc_k_uL": 7,
"platelets_k_uL": 322,
"creatinine_mg_dL": 1.07,
... |
ANODE_SYNTH_2025_10155 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 17.5,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 26
} | {
"age": 73,
"sex": "female",
"bmi": 28.7,
"smoking_pack_years": 40,
"ecog_performance_status": 0,
"comorbidities": []
} | {
"primary_tumor_size_cm": 7.5,
"metastatic_sites": [
"brain",
"contralateral lung",
"bone"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2024-01-09T00:00:00",
"best_response": "Stable disease",
"radiologic_response": {
"first_ct_8wk_change_percent": -32,
"peak_response_20wk_change_percent": -43
},
"pfs_months": 13.4
},
"second_line_the... | {
"overall_survival_months": 28.1,
"censored": false
} | [
{
"date": "2023-12-11T00:00:00",
"hemoglobin_g_dL": 15.4,
"wbc_k_uL": 10.9,
"platelets_k_uL": 350,
"creatinine_mg_dL": 1.16,
"alt_U_L": 23
},
{
"date": "2024-07-07T00:00:00",
"hemoglobin_g_dL": 11.6,
"wbc_k_uL": 4.9,
"platelets_k_uL": 121,
"creatinine_mg_dL": 1.3,
... |
ANODE_SYNTH_2025_10156 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 7.9,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 22
} | {
"age": 69,
"sex": "male",
"bmi": 18.8,
"smoking_pack_years": 25,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 7.2,
"metastatic_sites": [
"brain",
"pleura",
"bone"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2021-08-30T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -30,
"peak_response_20wk_change_percent": -33
},
"pfs_months": 24.11
},
"second_line_th... | {
"overall_survival_months": 46.6,
"censored": false
} | [
{
"date": "2021-08-03T00:00:00",
"hemoglobin_g_dL": 12.3,
"wbc_k_uL": 8.6,
"platelets_k_uL": 171,
"creatinine_mg_dL": 0.77,
"alt_U_L": 48
},
{
"date": "2022-02-26T00:00:00",
"hemoglobin_g_dL": 13.1,
"wbc_k_uL": 4.5,
"platelets_k_uL": 152,
"creatinine_mg_dL": 1.36,
... |
ANODE_SYNTH_2025_10157 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR L858R",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 3.3,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 4
} | {
"age": 76,
"sex": "female",
"bmi": 22.3,
"smoking_pack_years": 0,
"ecog_performance_status": 0,
"comorbidities": [
"hyperlipidemia",
"diabetes"
]
} | {
"primary_tumor_size_cm": 6,
"metastatic_sites": [
"brain"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2024-09-26T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -30,
"peak_response_20wk_change_percent": -37
},
"pfs_months": 21.42
},
"second_line... | {
"overall_survival_months": 33.9,
"censored": false
} | [
{
"date": "2024-08-09T00:00:00",
"hemoglobin_g_dL": 12.9,
"wbc_k_uL": 4.6,
"platelets_k_uL": 311,
"creatinine_mg_dL": 1.11,
"alt_U_L": 10
},
{
"date": "2025-03-25T00:00:00",
"hemoglobin_g_dL": 13.9,
"wbc_k_uL": 5.6,
"platelets_k_uL": 380,
"creatinine_mg_dL": 0.92,
... |
ANODE_SYNTH_2025_10158 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 13.4,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 12
} | {
"age": 74,
"sex": "male",
"bmi": 26.7,
"smoking_pack_years": 80,
"ecog_performance_status": 1,
"comorbidities": [
"hypertension",
"COPD"
]
} | {
"primary_tumor_size_cm": 4.9,
"metastatic_sites": [
"brain",
"bone"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2020-06-07T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -23,
"peak_response_20wk_change_percent": -30
},
"pfs_months": 13.73
},
"second_line_... | {
"overall_survival_months": 25.7,
"censored": false
} | [
{
"date": "2020-05-14T00:00:00",
"hemoglobin_g_dL": 12.9,
"wbc_k_uL": 10.1,
"platelets_k_uL": 285,
"creatinine_mg_dL": 0.97,
"alt_U_L": 43
},
{
"date": "2020-12-04T00:00:00",
"hemoglobin_g_dL": 10.4,
"wbc_k_uL": 4.8,
"platelets_k_uL": 137,
"creatinine_mg_dL": 1.03,
... |
ANODE_SYNTH_2025_10159 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 3.4,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 21
} | {
"age": 74,
"sex": "male",
"bmi": 23.2,
"smoking_pack_years": 35,
"ecog_performance_status": 2,
"comorbidities": [
"COPD"
]
} | {
"primary_tumor_size_cm": 5,
"metastatic_sites": [
"liver"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2025-03-14T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -15,
"peak_response_20wk_change_percent": -70
},
"pfs_months": 4.47
},
"second_line_t... | {
"overall_survival_months": 19.6,
"censored": false
} | [
{
"date": "2025-02-18T00:00:00",
"hemoglobin_g_dL": 13.9,
"wbc_k_uL": 8.2,
"platelets_k_uL": 263,
"creatinine_mg_dL": 1.27,
"alt_U_L": 76
},
{
"date": "2025-09-10T00:00:00",
"hemoglobin_g_dL": 12.5,
"wbc_k_uL": 5.5,
"platelets_k_uL": 245,
"creatinine_mg_dL": 1.35,
... |
ANODE_SYNTH_2025_10160 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 4.8,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 22
} | {
"age": 88,
"sex": "female",
"bmi": 29.5,
"smoking_pack_years": 0,
"ecog_performance_status": 2,
"comorbidities": [
"hypertension"
]
} | {
"primary_tumor_size_cm": 4.6,
"metastatic_sites": [
"liver",
"contralateral lung"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2022-10-08T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -33,
"peak_response_20wk_change_percent": -67
},
"pfs_months": 18.14
},
"second_line... | {
"overall_survival_months": 27.5,
"censored": true
} | [
{
"date": "2022-08-01T00:00:00",
"hemoglobin_g_dL": 14.3,
"wbc_k_uL": 5.4,
"platelets_k_uL": 421,
"creatinine_mg_dL": 1.11,
"alt_U_L": 39
},
{
"date": "2023-04-06T00:00:00",
"hemoglobin_g_dL": 11.1,
"wbc_k_uL": 6.8,
"platelets_k_uL": 248,
"creatinine_mg_dL": 1.23,
... |
ANODE_SYNTH_2025_10161 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR L858R",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 15.5,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 35
} | {
"age": 51,
"sex": "female",
"bmi": 20.2,
"smoking_pack_years": 0,
"ecog_performance_status": 2,
"comorbidities": [
"hyperlipidemia"
]
} | {
"primary_tumor_size_cm": 5.3,
"metastatic_sites": [
"pleura",
"liver",
"bone"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2025-07-23T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -58,
"peak_response_20wk_change_percent": -83
},
"pfs_months": 20.34
},
"second_line... | {
"overall_survival_months": 39.2,
"censored": false
} | [
{
"date": "2025-05-27T00:00:00",
"hemoglobin_g_dL": 14.1,
"wbc_k_uL": 5.4,
"platelets_k_uL": 307,
"creatinine_mg_dL": 0.81,
"alt_U_L": 37
},
{
"date": "2026-01-19T00:00:00",
"hemoglobin_g_dL": 11,
"wbc_k_uL": 7.7,
"platelets_k_uL": 254,
"creatinine_mg_dL": 1.56,
"... |
ANODE_SYNTH_2025_10162 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 14,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 34
} | {
"age": 64,
"sex": "female",
"bmi": 18.6,
"smoking_pack_years": 64,
"ecog_performance_status": 0,
"comorbidities": [
"hypertension",
"diabetes"
]
} | {
"primary_tumor_size_cm": 5.6,
"metastatic_sites": [
"liver",
"bone"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2021-02-16T00:00:00",
"best_response": "Stable disease",
"radiologic_response": {
"first_ct_8wk_change_percent": -37,
"peak_response_20wk_change_percent": -60
},
"pfs_months": 20.93
},
"second_line_th... | {
"overall_survival_months": 31.1,
"censored": true
} | [
{
"date": "2021-01-10T00:00:00",
"hemoglobin_g_dL": 12.5,
"wbc_k_uL": 8.2,
"platelets_k_uL": 342,
"creatinine_mg_dL": 0.95,
"alt_U_L": 20
},
{
"date": "2021-08-15T00:00:00",
"hemoglobin_g_dL": 12.1,
"wbc_k_uL": 6.8,
"platelets_k_uL": 206,
"creatinine_mg_dL": 1.52,
... |
ANODE_SYNTH_2025_10163 | Non-small cell lung cancer | Squamous cell carcinoma | IVB | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 11.2,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 27
} | {
"age": 56,
"sex": "male",
"bmi": 19.1,
"smoking_pack_years": 54,
"ecog_performance_status": 1,
"comorbidities": [
"COPD"
]
} | {
"primary_tumor_size_cm": 3.1,
"metastatic_sites": [
"pleura",
"brain",
"liver"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2021-09-30T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -45,
"peak_response_20wk_change_percent": -56
},
"pfs_months": 23.1
}... | {
"overall_survival_months": 32.4,
"censored": true
} | [
{
"date": "2021-09-07T00:00:00",
"hemoglobin_g_dL": 15.3,
"wbc_k_uL": 6,
"platelets_k_uL": 194,
"creatinine_mg_dL": 0.75,
"alt_U_L": 44
},
{
"date": "2022-03-29T00:00:00",
"hemoglobin_g_dL": 12.4,
"wbc_k_uL": 9,
"platelets_k_uL": 221,
"creatinine_mg_dL": 1.47,
"al... |
ANODE_SYNTH_2025_10164 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 8,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 13
} | {
"age": 62,
"sex": "female",
"bmi": 22.7,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": [
"hypertension",
"COPD"
]
} | {
"primary_tumor_size_cm": 6.5,
"metastatic_sites": [
"bone",
"liver"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2023-06-10T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -19,
"peak_response_20wk_change_percent": -51
},
"pfs_months": 17.74
},
"second_line... | {
"overall_survival_months": 33.6,
"censored": true
} | [
{
"date": "2023-05-12T00:00:00",
"hemoglobin_g_dL": 14.2,
"wbc_k_uL": 6.7,
"platelets_k_uL": 186,
"creatinine_mg_dL": 0.96,
"alt_U_L": 47
},
{
"date": "2023-12-07T00:00:00",
"hemoglobin_g_dL": 12.7,
"wbc_k_uL": 4.1,
"platelets_k_uL": 275,
"creatinine_mg_dL": 1.06,
... |
ANODE_SYNTH_2025_10165 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "EGFR L858R",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 9.1,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 28
} | {
"age": 52,
"sex": "female",
"bmi": 26.6,
"smoking_pack_years": 0,
"ecog_performance_status": 0,
"comorbidities": [
"hyperlipidemia"
]
} | {
"primary_tumor_size_cm": 3.2,
"metastatic_sites": [
"brain",
"pleura"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2020-05-03T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -41,
"peak_response_20wk_change_percent": -55
},
"pfs_months": 24.8
},
"second_line_... | {
"overall_survival_months": 43.1,
"censored": true
} | [
{
"date": "2020-04-04T00:00:00",
"hemoglobin_g_dL": 12.8,
"wbc_k_uL": 8.9,
"platelets_k_uL": 293,
"creatinine_mg_dL": 0.69,
"alt_U_L": 36
},
{
"date": "2020-10-30T00:00:00",
"hemoglobin_g_dL": 12.9,
"wbc_k_uL": 4.2,
"platelets_k_uL": 378,
"creatinine_mg_dL": 0.78,
... |
ANODE_SYNTH_2025_10166 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 2.7,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 7
} | {
"age": 54,
"sex": "female",
"bmi": 34.6,
"smoking_pack_years": 74,
"ecog_performance_status": 1,
"comorbidities": [
"diabetes",
"hypertension"
]
} | {
"primary_tumor_size_cm": 3.6,
"metastatic_sites": [
"brain"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2023-11-25T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -12,
"peak_response_20wk_change_percent": -45
},
"pfs_months": 9.72
},
"second_line_t... | {
"overall_survival_months": 15.9,
"censored": false
} | [
{
"date": "2023-10-03T00:00:00",
"hemoglobin_g_dL": 12.2,
"wbc_k_uL": 9,
"platelets_k_uL": 382,
"creatinine_mg_dL": 1.26,
"alt_U_L": 75
},
{
"date": "2024-05-23T00:00:00",
"hemoglobin_g_dL": 12.6,
"wbc_k_uL": 8.2,
"platelets_k_uL": 191,
"creatinine_mg_dL": 1.17,
"... |
ANODE_SYNTH_2025_10167 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 11,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 9
} | {
"age": 57,
"sex": "female",
"bmi": 36.6,
"smoking_pack_years": 26,
"ecog_performance_status": 2,
"comorbidities": [
"COPD",
"hypertension"
]
} | {
"primary_tumor_size_cm": 5.6,
"metastatic_sites": [
"brain",
"bone",
"liver"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2021-05-14T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -30,
"peak_response_20wk_change_percent": -41
},
"pfs_months": 37.52
},
"second_line_th... | {
"overall_survival_months": 66.7,
"censored": false
} | [
{
"date": "2021-03-22T00:00:00",
"hemoglobin_g_dL": 12.4,
"wbc_k_uL": 9.4,
"platelets_k_uL": 273,
"creatinine_mg_dL": 1.1,
"alt_U_L": 39
},
{
"date": "2021-11-10T00:00:00",
"hemoglobin_g_dL": 10.2,
"wbc_k_uL": 8.2,
"platelets_k_uL": 228,
"creatinine_mg_dL": 1.08,
... |
ANODE_SYNTH_2025_10168 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 6.3,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 9
} | {
"age": 54,
"sex": "female",
"bmi": 24.6,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 7.2,
"metastatic_sites": [
"pleura",
"liver"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2023-01-01T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -50,
"peak_response_20wk_change_percent": -42
},
"pfs_months": 23.75
},
"second_line... | {
"overall_survival_months": 37.3,
"censored": false
} | [
{
"date": "2022-12-13T00:00:00",
"hemoglobin_g_dL": 12,
"wbc_k_uL": 9.2,
"platelets_k_uL": 267,
"creatinine_mg_dL": 1.09,
"alt_U_L": 80
},
{
"date": "2023-06-30T00:00:00",
"hemoglobin_g_dL": 12.5,
"wbc_k_uL": 5.2,
"platelets_k_uL": 146,
"creatinine_mg_dL": 0.78,
"... |
ANODE_SYNTH_2025_10169 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 10.9,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 29
} | {
"age": 57,
"sex": "female",
"bmi": 21.5,
"smoking_pack_years": 67,
"ecog_performance_status": 1,
"comorbidities": [
"diabetes",
"hyperlipidemia"
]
} | {
"primary_tumor_size_cm": 7.1,
"metastatic_sites": [
"contralateral lung"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2020-06-26T00:00:00",
"best_response": "Stable disease",
"radiologic_response": {
"first_ct_8wk_change_percent": -41,
"peak_response_20wk_change_percent": -50
},
"pfs_months": 19.06
},
"second_line_th... | {
"overall_survival_months": 24.8,
"censored": true
} | [
{
"date": "2020-04-22T00:00:00",
"hemoglobin_g_dL": 12.3,
"wbc_k_uL": 9.1,
"platelets_k_uL": 235,
"creatinine_mg_dL": 0.89,
"alt_U_L": 24
},
{
"date": "2020-12-23T00:00:00",
"hemoglobin_g_dL": 10.7,
"wbc_k_uL": 8,
"platelets_k_uL": 314,
"creatinine_mg_dL": 0.74,
"... |
ANODE_SYNTH_2025_10170 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 8.9,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 10
} | {
"age": 88,
"sex": "female",
"bmi": 37.1,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": [
"hypertension",
"COPD"
]
} | {
"primary_tumor_size_cm": 4.6,
"metastatic_sites": [
"contralateral lung"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2020-04-10T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -57,
"peak_response_20wk_change_percent": -39
},
"pfs_months": 18.92
},
"second_line... | {
"overall_survival_months": 29.7,
"censored": false
} | [
{
"date": "2020-02-19T00:00:00",
"hemoglobin_g_dL": 12.8,
"wbc_k_uL": 7.4,
"platelets_k_uL": 439,
"creatinine_mg_dL": 1.25,
"alt_U_L": 41
},
{
"date": "2020-10-07T00:00:00",
"hemoglobin_g_dL": 10.4,
"wbc_k_uL": 6.1,
"platelets_k_uL": 270,
"creatinine_mg_dL": 1.5,
... |
ANODE_SYNTH_2025_10171 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR L858R",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 6.3,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 2
} | {
"age": 83,
"sex": "female",
"bmi": 19.9,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": [
"diabetes"
]
} | {
"primary_tumor_size_cm": 5.9,
"metastatic_sites": [
"brain",
"bone",
"liver"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2022-07-27T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -33,
"peak_response_20wk_change_percent": -54
},
"pfs_months": 25.92
},
"second_line... | {
"overall_survival_months": 42.3,
"censored": true
} | [
{
"date": "2022-07-03T00:00:00",
"hemoglobin_g_dL": 12.1,
"wbc_k_uL": 10.6,
"platelets_k_uL": 339,
"creatinine_mg_dL": 0.62,
"alt_U_L": 67
},
{
"date": "2023-01-23T00:00:00",
"hemoglobin_g_dL": 10.7,
"wbc_k_uL": 6,
"platelets_k_uL": 219,
"creatinine_mg_dL": 0.89,
... |
ANODE_SYNTH_2025_10172 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "EGFR L858R",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 16,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 25
} | {
"age": 66,
"sex": "female",
"bmi": 24.4,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 3.7,
"metastatic_sites": [
"contralateral lung",
"brain"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2023-08-25T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -11,
"peak_response_20wk_change_percent": -81
},
"pfs_months": 30.16
},
"second_line... | {
"overall_survival_months": 45.8,
"censored": false
} | [
{
"date": "2023-07-15T00:00:00",
"hemoglobin_g_dL": 13.6,
"wbc_k_uL": 6,
"platelets_k_uL": 302,
"creatinine_mg_dL": 0.87,
"alt_U_L": 12
},
{
"date": "2024-02-21T00:00:00",
"hemoglobin_g_dL": 10.4,
"wbc_k_uL": 5.4,
"platelets_k_uL": 192,
"creatinine_mg_dL": 0.77,
"... |
ANODE_SYNTH_2025_10173 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 16,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 20
} | {
"age": 84,
"sex": "male",
"bmi": 25.5,
"smoking_pack_years": 23,
"ecog_performance_status": 1,
"comorbidities": [
"hypertension"
]
} | {
"primary_tumor_size_cm": 3.4,
"metastatic_sites": [
"contralateral lung",
"liver",
"pleura"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2022-03-17T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -23,
"peak_response_20wk_change_percent": -64
},
"pfs_months": 6.01
},
"second_line_t... | {
"overall_survival_months": 10,
"censored": false
} | [
{
"date": "2022-02-05T00:00:00",
"hemoglobin_g_dL": 12.1,
"wbc_k_uL": 4.7,
"platelets_k_uL": 297,
"creatinine_mg_dL": 0.64,
"alt_U_L": 60
},
{
"date": "2022-09-13T00:00:00",
"hemoglobin_g_dL": 10.5,
"wbc_k_uL": 5.5,
"platelets_k_uL": 346,
"creatinine_mg_dL": 1.24,
... |
ANODE_SYNTH_2025_10174 | Non-small cell lung cancer | Squamous cell carcinoma | IVB | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 6.3,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 8
} | {
"age": 59,
"sex": "female",
"bmi": 26.1,
"smoking_pack_years": 39,
"ecog_performance_status": 1,
"comorbidities": [
"hyperlipidemia"
]
} | {
"primary_tumor_size_cm": 8.1,
"metastatic_sites": [
"bone"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2024-02-29T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -57,
"peak_response_20wk_change_percent": -73
},
"pfs_months": 21.91
... | {
"overall_survival_months": 32.6,
"censored": false
} | [
{
"date": "2024-02-02T00:00:00",
"hemoglobin_g_dL": 15.1,
"wbc_k_uL": 8.5,
"platelets_k_uL": 368,
"creatinine_mg_dL": 1.04,
"alt_U_L": 21
},
{
"date": "2024-08-27T00:00:00",
"hemoglobin_g_dL": 11.3,
"wbc_k_uL": 8.6,
"platelets_k_uL": 222,
"creatinine_mg_dL": 0.83,
... |
ANODE_SYNTH_2025_10175 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR L858R",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 15.4,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 25
} | {
"age": 80,
"sex": "female",
"bmi": 37.8,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": [
"diabetes",
"hyperlipidemia"
]
} | {
"primary_tumor_size_cm": 3.1,
"metastatic_sites": [
"bone",
"contralateral lung",
"liver"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2022-08-23T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -10,
"peak_response_20wk_change_percent": -47
},
"pfs_months": 17.97
},
"second_line... | {
"overall_survival_months": 25.3,
"censored": false
} | [
{
"date": "2022-07-13T00:00:00",
"hemoglobin_g_dL": 14.3,
"wbc_k_uL": 6.1,
"platelets_k_uL": 318,
"creatinine_mg_dL": 0.77,
"alt_U_L": 79
},
{
"date": "2023-02-19T00:00:00",
"hemoglobin_g_dL": 12.9,
"wbc_k_uL": 4.2,
"platelets_k_uL": 335,
"creatinine_mg_dL": 1,
"a... |
ANODE_SYNTH_2025_10176 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 5.9,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 14
} | {
"age": 58,
"sex": "female",
"bmi": 26.4,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": [
"hypertension"
]
} | {
"primary_tumor_size_cm": 7.6,
"metastatic_sites": [
"pleura",
"brain",
"liver"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2020-07-25T00:00:00",
"best_response": "Stable disease",
"radiologic_response": {
"first_ct_8wk_change_percent": -22,
"peak_response_20wk_change_percent": -79
},
"pfs_months": 13.08
},
"second_line_t... | {
"overall_survival_months": 20.8,
"censored": false
} | [
{
"date": "2020-06-23T00:00:00",
"hemoglobin_g_dL": 14.5,
"wbc_k_uL": 7.9,
"platelets_k_uL": 217,
"creatinine_mg_dL": 0.77,
"alt_U_L": 37
},
{
"date": "2021-01-21T00:00:00",
"hemoglobin_g_dL": 13.9,
"wbc_k_uL": 3.9,
"platelets_k_uL": 359,
"creatinine_mg_dL": 1.43,
... |
ANODE_SYNTH_2025_10177 | Non-small cell lung cancer | Squamous cell carcinoma | IV | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 2.1,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 9
} | {
"age": 74,
"sex": "male",
"bmi": 34,
"smoking_pack_years": 43,
"ecog_performance_status": 1,
"comorbidities": [
"hypertension",
"diabetes"
]
} | {
"primary_tumor_size_cm": 4.5,
"metastatic_sites": [
"liver",
"contralateral lung",
"brain"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2022-09-04T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -52,
"peak_response_20wk_change_percent": -34
},
"pfs_months": 26.09
... | {
"overall_survival_months": 38,
"censored": true
} | [
{
"date": "2022-07-26T00:00:00",
"hemoglobin_g_dL": 11.8,
"wbc_k_uL": 9,
"platelets_k_uL": 176,
"creatinine_mg_dL": 1.06,
"alt_U_L": 23
},
{
"date": "2023-03-03T00:00:00",
"hemoglobin_g_dL": 13.8,
"wbc_k_uL": 5.7,
"platelets_k_uL": 140,
"creatinine_mg_dL": 1.3,
"a... |
ANODE_SYNTH_2025_10178 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 10.2,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 7
} | {
"age": 85,
"sex": "female",
"bmi": 25.3,
"smoking_pack_years": 0,
"ecog_performance_status": 2,
"comorbidities": [
"hypertension",
"hyperlipidemia"
]
} | {
"primary_tumor_size_cm": 6.9,
"metastatic_sites": [
"pleura",
"liver"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2020-08-20T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -47,
"peak_response_20wk_change_percent": -78
},
"pfs_months": 22.34
},
"second_line... | {
"overall_survival_months": 40.7,
"censored": false
} | [
{
"date": "2020-06-22T00:00:00",
"hemoglobin_g_dL": 11.8,
"wbc_k_uL": 6.7,
"platelets_k_uL": 365,
"creatinine_mg_dL": 0.9,
"alt_U_L": 25
},
{
"date": "2021-02-16T00:00:00",
"hemoglobin_g_dL": 13.2,
"wbc_k_uL": 8.1,
"platelets_k_uL": 291,
"creatinine_mg_dL": 1,
"al... |
ANODE_SYNTH_2025_10179 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 7,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 0
} | {
"age": 73,
"sex": "female",
"bmi": 20.6,
"smoking_pack_years": 0,
"ecog_performance_status": 2,
"comorbidities": []
} | {
"primary_tumor_size_cm": 3.3,
"metastatic_sites": [
"liver",
"bone"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2025-08-25T00:00:00",
"best_response": "Stable disease",
"radiologic_response": {
"first_ct_8wk_change_percent": -27,
"peak_response_20wk_change_percent": -47
},
"pfs_months": 26.87
},
"second_line_t... | {
"overall_survival_months": 37.7,
"censored": false
} | [
{
"date": "2025-07-19T00:00:00",
"hemoglobin_g_dL": 13,
"wbc_k_uL": 8.1,
"platelets_k_uL": 442,
"creatinine_mg_dL": 0.64,
"alt_U_L": 75
},
{
"date": "2026-02-21T00:00:00",
"hemoglobin_g_dL": 11.4,
"wbc_k_uL": 8.9,
"platelets_k_uL": 228,
"creatinine_mg_dL": 0.8,
"a... |
ANODE_SYNTH_2025_10180 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 13.8,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 12
} | {
"age": 84,
"sex": "female",
"bmi": 21.8,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": [
"COPD"
]
} | {
"primary_tumor_size_cm": 7.4,
"metastatic_sites": [
"bone"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2020-08-06T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -20,
"peak_response_20wk_change_percent": -64
},
"pfs_months": 24.34
},
"second_line... | {
"overall_survival_months": 37.8,
"censored": true
} | [
{
"date": "2020-07-05T00:00:00",
"hemoglobin_g_dL": 12.3,
"wbc_k_uL": 10.3,
"platelets_k_uL": 267,
"creatinine_mg_dL": 0.84,
"alt_U_L": 23
},
{
"date": "2021-02-02T00:00:00",
"hemoglobin_g_dL": 13,
"wbc_k_uL": 7.2,
"platelets_k_uL": 362,
"creatinine_mg_dL": 0.77,
... |
ANODE_SYNTH_2025_10181 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 6.1,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 26
} | {
"age": 72,
"sex": "female",
"bmi": 36.4,
"smoking_pack_years": 54,
"ecog_performance_status": 1,
"comorbidities": [
"hyperlipidemia"
]
} | {
"primary_tumor_size_cm": 8,
"metastatic_sites": [
"bone"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2020-11-06T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -29,
"peak_response_20wk_change_percent": -83
},
"pfs_months": 9.3
},
"second_line_th... | {
"overall_survival_months": 13.2,
"censored": true
} | [
{
"date": "2020-09-28T00:00:00",
"hemoglobin_g_dL": 12.2,
"wbc_k_uL": 6.7,
"platelets_k_uL": 214,
"creatinine_mg_dL": 1.28,
"alt_U_L": 48
},
{
"date": "2021-05-05T00:00:00",
"hemoglobin_g_dL": 10.1,
"wbc_k_uL": 4,
"platelets_k_uL": 216,
"creatinine_mg_dL": 1.11,
"... |
ANODE_SYNTH_2025_10182 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR L858R",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 5.9,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 15
} | {
"age": 59,
"sex": "female",
"bmi": 31.6,
"smoking_pack_years": 0,
"ecog_performance_status": 2,
"comorbidities": [
"diabetes",
"COPD"
]
} | {
"primary_tumor_size_cm": 3.3,
"metastatic_sites": [
"brain"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2020-03-10T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -29,
"peak_response_20wk_change_percent": -72
},
"pfs_months": 26.12
},
"second_line... | {
"overall_survival_months": 39.8,
"censored": false
} | [
{
"date": "2020-02-21T00:00:00",
"hemoglobin_g_dL": 13.4,
"wbc_k_uL": 9.8,
"platelets_k_uL": 199,
"creatinine_mg_dL": 0.81,
"alt_U_L": 26
},
{
"date": "2020-09-06T00:00:00",
"hemoglobin_g_dL": 12.5,
"wbc_k_uL": 6.3,
"platelets_k_uL": 315,
"creatinine_mg_dL": 1.55,
... |
ANODE_SYNTH_2025_10183 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 8.1,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 8
} | {
"age": 82,
"sex": "female",
"bmi": 36.1,
"smoking_pack_years": 20,
"ecog_performance_status": 2,
"comorbidities": []
} | {
"primary_tumor_size_cm": 4.3,
"metastatic_sites": [
"liver",
"bone",
"brain"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2024-05-04T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -13,
"peak_response_20wk_change_percent": -70
},
"pfs_months": 8.8
},
"second_line_th... | {
"overall_survival_months": 18.5,
"censored": false
} | [
{
"date": "2024-04-10T00:00:00",
"hemoglobin_g_dL": 12.6,
"wbc_k_uL": 9.4,
"platelets_k_uL": 221,
"creatinine_mg_dL": 0.7,
"alt_U_L": 73
},
{
"date": "2024-10-31T00:00:00",
"hemoglobin_g_dL": 10.9,
"wbc_k_uL": 6.5,
"platelets_k_uL": 367,
"creatinine_mg_dL": 1.4,
"... |
ANODE_SYNTH_2025_10184 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 16.5,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 19
} | {
"age": 52,
"sex": "female",
"bmi": 28.8,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 8.4,
"metastatic_sites": [
"brain",
"liver",
"contralateral lung"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2021-03-06T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -46,
"peak_response_20wk_change_percent": -41
},
"pfs_months": 25.49
},
"second_line... | {
"overall_survival_months": 43.1,
"censored": true
} | [
{
"date": "2021-02-12T00:00:00",
"hemoglobin_g_dL": 13.3,
"wbc_k_uL": 7,
"platelets_k_uL": 226,
"creatinine_mg_dL": 0.99,
"alt_U_L": 40
},
{
"date": "2021-09-02T00:00:00",
"hemoglobin_g_dL": 11.4,
"wbc_k_uL": 5.1,
"platelets_k_uL": 336,
"creatinine_mg_dL": 1.3,
"a... |
ANODE_SYNTH_2025_10185 | Non-small cell lung cancer | Squamous cell carcinoma | IVB | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 11.7,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 35
} | {
"age": 73,
"sex": "female",
"bmi": 24.9,
"smoking_pack_years": 39,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 3.2,
"metastatic_sites": [
"brain"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2020-04-05T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -32,
"peak_response_20wk_change_percent": -31
},
"pfs_months": 16.66
... | {
"overall_survival_months": 23.7,
"censored": false
} | [
{
"date": "2020-02-14T00:00:00",
"hemoglobin_g_dL": 12,
"wbc_k_uL": 5.7,
"platelets_k_uL": 363,
"creatinine_mg_dL": 0.69,
"alt_U_L": 34
},
{
"date": "2020-10-02T00:00:00",
"hemoglobin_g_dL": 12.1,
"wbc_k_uL": 6.1,
"platelets_k_uL": 131,
"creatinine_mg_dL": 1.43,
"... |
ANODE_SYNTH_2025_10186 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 14.2,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 24
} | {
"age": 72,
"sex": "male",
"bmi": 31.7,
"smoking_pack_years": 74,
"ecog_performance_status": 0,
"comorbidities": [
"hypertension"
]
} | {
"primary_tumor_size_cm": 4,
"metastatic_sites": [
"brain",
"pleura",
"bone"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2020-04-08T00:00:00",
"best_response": "Stable disease",
"radiologic_response": {
"first_ct_8wk_change_percent": -26,
"peak_response_20wk_change_percent": -78
},
"pfs_months": 45.31
},
"second_line_ther... | {
"overall_survival_months": 73.7,
"censored": false
} | [
{
"date": "2020-02-18T00:00:00",
"hemoglobin_g_dL": 12.2,
"wbc_k_uL": 9.5,
"platelets_k_uL": 155,
"creatinine_mg_dL": 1.04,
"alt_U_L": 72
},
{
"date": "2020-10-05T00:00:00",
"hemoglobin_g_dL": 10.8,
"wbc_k_uL": 4.6,
"platelets_k_uL": 253,
"creatinine_mg_dL": 0.83,
... |
ANODE_SYNTH_2025_10187 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "EGFR L858R",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 13.1,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 2
} | {
"age": 56,
"sex": "female",
"bmi": 32.9,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 6.5,
"metastatic_sites": [
"contralateral lung"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2021-05-08T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -53,
"peak_response_20wk_change_percent": -51
},
"pfs_months": 29.08
},
"second_line... | {
"overall_survival_months": 40.5,
"censored": true
} | [
{
"date": "2021-04-21T00:00:00",
"hemoglobin_g_dL": 12.9,
"wbc_k_uL": 9,
"platelets_k_uL": 218,
"creatinine_mg_dL": 1.17,
"alt_U_L": 28
},
{
"date": "2021-11-04T00:00:00",
"hemoglobin_g_dL": 13.5,
"wbc_k_uL": 7,
"platelets_k_uL": 164,
"creatinine_mg_dL": 0.95,
"al... |
ANODE_SYNTH_2025_10188 | Non-small cell lung cancer | Squamous cell carcinoma | IV | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 4.5,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 26
} | {
"age": 76,
"sex": "male",
"bmi": 20.6,
"smoking_pack_years": 54,
"ecog_performance_status": 1,
"comorbidities": [
"hyperlipidemia"
]
} | {
"primary_tumor_size_cm": 5.8,
"metastatic_sites": [
"bone",
"liver",
"brain"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2020-03-16T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -23,
"peak_response_20wk_change_percent": -51
},
"pfs_months": 19.61
... | {
"overall_survival_months": 35.2,
"censored": false
} | [
{
"date": "2020-02-15T00:00:00",
"hemoglobin_g_dL": 14.9,
"wbc_k_uL": 6.6,
"platelets_k_uL": 445,
"creatinine_mg_dL": 1.21,
"alt_U_L": 50
},
{
"date": "2020-09-12T00:00:00",
"hemoglobin_g_dL": 12.2,
"wbc_k_uL": 6.6,
"platelets_k_uL": 144,
"creatinine_mg_dL": 1.11,
... |
ANODE_SYNTH_2025_10189 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR L858R",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 4.4,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 22
} | {
"age": 86,
"sex": "female",
"bmi": 18.9,
"smoking_pack_years": 0,
"ecog_performance_status": 0,
"comorbidities": [
"hypertension"
]
} | {
"primary_tumor_size_cm": 5.1,
"metastatic_sites": [
"pleura",
"liver"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2021-09-16T00:00:00",
"best_response": "Stable disease",
"radiologic_response": {
"first_ct_8wk_change_percent": -60,
"peak_response_20wk_change_percent": -53
},
"pfs_months": 19.98
},
"second_line_t... | {
"overall_survival_months": 41.9,
"censored": false
} | [
{
"date": "2021-08-08T00:00:00",
"hemoglobin_g_dL": 11.9,
"wbc_k_uL": 4.6,
"platelets_k_uL": 164,
"creatinine_mg_dL": 0.76,
"alt_U_L": 64
},
{
"date": "2022-03-15T00:00:00",
"hemoglobin_g_dL": 12.5,
"wbc_k_uL": 7.1,
"platelets_k_uL": 297,
"creatinine_mg_dL": 1.26,
... |
ANODE_SYNTH_2025_10190 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 12.7,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 12
} | {
"age": 59,
"sex": "female",
"bmi": 26.4,
"smoking_pack_years": 68,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 8.1,
"metastatic_sites": [
"brain"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2025-04-12T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -30,
"peak_response_20wk_change_percent": -48
},
"pfs_months": 43.01
},
"second_line_th... | {
"overall_survival_months": 67.9,
"censored": true
} | [
{
"date": "2025-03-24T00:00:00",
"hemoglobin_g_dL": 15.5,
"wbc_k_uL": 8.4,
"platelets_k_uL": 329,
"creatinine_mg_dL": 0.85,
"alt_U_L": 64
},
{
"date": "2025-10-09T00:00:00",
"hemoglobin_g_dL": 11.9,
"wbc_k_uL": 6.1,
"platelets_k_uL": 338,
"creatinine_mg_dL": 1.35,
... |
ANODE_SYNTH_2025_10191 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "EGFR L858R",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 5.1,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 24
} | {
"age": 66,
"sex": "female",
"bmi": 36.2,
"smoking_pack_years": 0,
"ecog_performance_status": 2,
"comorbidities": []
} | {
"primary_tumor_size_cm": 6.2,
"metastatic_sites": [
"liver",
"bone"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2021-05-06T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -41,
"peak_response_20wk_change_percent": -53
},
"pfs_months": 23.03
},
"second_line... | {
"overall_survival_months": 33.4,
"censored": true
} | [
{
"date": "2021-03-23T00:00:00",
"hemoglobin_g_dL": 11.5,
"wbc_k_uL": 6.5,
"platelets_k_uL": 343,
"creatinine_mg_dL": 1,
"alt_U_L": 53
},
{
"date": "2021-11-02T00:00:00",
"hemoglobin_g_dL": 10.7,
"wbc_k_uL": 4.6,
"platelets_k_uL": 131,
"creatinine_mg_dL": 1.46,
"a... |
ANODE_SYNTH_2025_10192 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 9.9,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 29
} | {
"age": 68,
"sex": "female",
"bmi": 31.2,
"smoking_pack_years": 35,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 7.6,
"metastatic_sites": [
"liver",
"brain",
"contralateral lung"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2022-09-28T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -15,
"peak_response_20wk_change_percent": -85
},
"pfs_months": 42.55
},
"second_line_th... | {
"overall_survival_months": 73.2,
"censored": false
} | [
{
"date": "2022-08-27T00:00:00",
"hemoglobin_g_dL": 13.8,
"wbc_k_uL": 6.2,
"platelets_k_uL": 230,
"creatinine_mg_dL": 0.6,
"alt_U_L": 75
},
{
"date": "2023-03-27T00:00:00",
"hemoglobin_g_dL": 13.7,
"wbc_k_uL": 3.9,
"platelets_k_uL": 378,
"creatinine_mg_dL": 1.25,
... |
ANODE_SYNTH_2025_10193 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 11.8,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 23
} | {
"age": 78,
"sex": "male",
"bmi": 26.8,
"smoking_pack_years": 12,
"ecog_performance_status": 0,
"comorbidities": [
"COPD",
"hyperlipidemia"
]
} | {
"primary_tumor_size_cm": 4.6,
"metastatic_sites": [
"bone"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2024-02-10T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -40,
"peak_response_20wk_change_percent": -62
},
"pfs_months": 37.91
},
"second_line_th... | {
"overall_survival_months": 68.7,
"censored": false
} | [
{
"date": "2024-01-03T00:00:00",
"hemoglobin_g_dL": 11.6,
"wbc_k_uL": 8,
"platelets_k_uL": 265,
"creatinine_mg_dL": 0.88,
"alt_U_L": 21
},
{
"date": "2024-08-08T00:00:00",
"hemoglobin_g_dL": 12.9,
"wbc_k_uL": 6.2,
"platelets_k_uL": 204,
"creatinine_mg_dL": 1.4,
"a... |
ANODE_SYNTH_2025_10194 | Non-small cell lung cancer | Squamous cell carcinoma | IV | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 10.9,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 9
} | {
"age": 70,
"sex": "male",
"bmi": 30,
"smoking_pack_years": 51,
"ecog_performance_status": 1,
"comorbidities": [
"diabetes",
"COPD"
]
} | {
"primary_tumor_size_cm": 6.4,
"metastatic_sites": [
"brain"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2020-11-20T00:00:00",
"best_response": "Stable disease",
"radiologic_response": {
"first_ct_8wk_change_percent": -53,
"peak_response_20wk_change_percent": -36
},
"pfs_months": 17.12
},... | {
"overall_survival_months": 34.6,
"censored": false
} | [
{
"date": "2020-10-15T00:00:00",
"hemoglobin_g_dL": 13.3,
"wbc_k_uL": 11,
"platelets_k_uL": 178,
"creatinine_mg_dL": 1.16,
"alt_U_L": 25
},
{
"date": "2021-05-19T00:00:00",
"hemoglobin_g_dL": 13.3,
"wbc_k_uL": 8.3,
"platelets_k_uL": 288,
"creatinine_mg_dL": 1.15,
... |
ANODE_SYNTH_2025_10195 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 15.6,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 5
} | {
"age": 65,
"sex": "male",
"bmi": 33,
"smoking_pack_years": 69,
"ecog_performance_status": 2,
"comorbidities": []
} | {
"primary_tumor_size_cm": 5.8,
"metastatic_sites": [
"pleura",
"bone",
"contralateral lung"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2021-09-28T00:00:00",
"best_response": "Stable disease",
"radiologic_response": {
"first_ct_8wk_change_percent": -32,
"peak_response_20wk_change_percent": -46
},
"pfs_months": 32.59
},
"second_line_ther... | {
"overall_survival_months": 65.5,
"censored": true
} | [
{
"date": "2021-09-03T00:00:00",
"hemoglobin_g_dL": 15,
"wbc_k_uL": 5.4,
"platelets_k_uL": 212,
"creatinine_mg_dL": 1.16,
"alt_U_L": 12
},
{
"date": "2022-03-27T00:00:00",
"hemoglobin_g_dL": 12,
"wbc_k_uL": 7.9,
"platelets_k_uL": 289,
"creatinine_mg_dL": 1.23,
"al... |
ANODE_SYNTH_2025_10196 | Non-small cell lung cancer | Squamous cell carcinoma | IV | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 8.1,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 31
} | {
"age": 79,
"sex": "male",
"bmi": 32.5,
"smoking_pack_years": 29,
"ecog_performance_status": 0,
"comorbidities": [
"hyperlipidemia",
"diabetes"
]
} | {
"primary_tumor_size_cm": 6.8,
"metastatic_sites": [
"bone",
"liver",
"brain"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2024-09-02T00:00:00",
"best_response": "Stable disease",
"radiologic_response": {
"first_ct_8wk_change_percent": -40,
"peak_response_20wk_change_percent": -37
},
"pfs_months": 12.35
},... | {
"overall_survival_months": 29.4,
"censored": true
} | [
{
"date": "2024-08-05T00:00:00",
"hemoglobin_g_dL": 12.4,
"wbc_k_uL": 8.2,
"platelets_k_uL": 347,
"creatinine_mg_dL": 0.63,
"alt_U_L": 79
},
{
"date": "2025-03-01T00:00:00",
"hemoglobin_g_dL": 10.9,
"wbc_k_uL": 5.5,
"platelets_k_uL": 155,
"creatinine_mg_dL": 1.54,
... |
ANODE_SYNTH_2025_10197 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR L858R",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 12.1,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 18
} | {
"age": 65,
"sex": "female",
"bmi": 20.5,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 4.2,
"metastatic_sites": [
"pleura",
"brain",
"bone"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2023-06-15T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -28,
"peak_response_20wk_change_percent": -37
},
"pfs_months": 29.73
},
"second_line... | {
"overall_survival_months": 50.9,
"censored": false
} | [
{
"date": "2023-05-10T00:00:00",
"hemoglobin_g_dL": 15.2,
"wbc_k_uL": 9.7,
"platelets_k_uL": 203,
"creatinine_mg_dL": 0.76,
"alt_U_L": 18
},
{
"date": "2023-12-12T00:00:00",
"hemoglobin_g_dL": 13,
"wbc_k_uL": 4.6,
"platelets_k_uL": 343,
"creatinine_mg_dL": 1.35,
"... |
ANODE_SYNTH_2025_10198 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 16.4,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 32
} | {
"age": 58,
"sex": "male",
"bmi": 29.8,
"smoking_pack_years": 75,
"ecog_performance_status": 1,
"comorbidities": [
"diabetes",
"hypertension"
]
} | {
"primary_tumor_size_cm": 6.2,
"metastatic_sites": [
"contralateral lung",
"bone",
"liver"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2025-03-12T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -13,
"peak_response_20wk_change_percent": -63
},
"pfs_months": 28.06
},
"second_line_th... | {
"overall_survival_months": 51.4,
"censored": false
} | [
{
"date": "2025-02-08T00:00:00",
"hemoglobin_g_dL": 12,
"wbc_k_uL": 7,
"platelets_k_uL": 185,
"creatinine_mg_dL": 1.11,
"alt_U_L": 48
},
{
"date": "2025-09-08T00:00:00",
"hemoglobin_g_dL": 11,
"wbc_k_uL": 4.9,
"platelets_k_uL": 352,
"creatinine_mg_dL": 1.41,
"alt_... |
ANODE_SYNTH_2025_10199 | Non-small cell lung cancer | Squamous cell carcinoma | IV | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 13.7,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 32
} | {
"age": 67,
"sex": "female",
"bmi": 35.5,
"smoking_pack_years": 41,
"ecog_performance_status": 0,
"comorbidities": [
"hypertension"
]
} | {
"primary_tumor_size_cm": 3.9,
"metastatic_sites": [
"liver",
"contralateral lung",
"pleura"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2020-07-11T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -20,
"peak_response_20wk_change_percent": -59
},
"pfs_months": 24.74
... | {
"overall_survival_months": 48.5,
"censored": false
} | [
{
"date": "2020-06-19T00:00:00",
"hemoglobin_g_dL": 12.5,
"wbc_k_uL": 5.9,
"platelets_k_uL": 433,
"creatinine_mg_dL": 1.24,
"alt_U_L": 70
},
{
"date": "2021-01-07T00:00:00",
"hemoglobin_g_dL": 10.3,
"wbc_k_uL": 4.7,
"platelets_k_uL": 330,
"creatinine_mg_dL": 1.2,
... |
ANODE_SYNTH_2025_10200 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 5.1,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 19
} | {
"age": 71,
"sex": "female",
"bmi": 37.1,
"smoking_pack_years": 40,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 8.2,
"metastatic_sites": [
"bone",
"liver",
"contralateral lung"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2023-04-15T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -43,
"peak_response_20wk_change_percent": -77
},
"pfs_months": 4.99
},
"second_line_t... | {
"overall_survival_months": 8.9,
"censored": false
} | [
{
"date": "2023-04-01T00:00:00",
"hemoglobin_g_dL": 13.8,
"wbc_k_uL": 8.6,
"platelets_k_uL": 419,
"creatinine_mg_dL": 0.66,
"alt_U_L": 14
},
{
"date": "2023-10-12T00:00:00",
"hemoglobin_g_dL": 11.4,
"wbc_k_uL": 8.1,
"platelets_k_uL": 164,
"creatinine_mg_dL": 1.06,
... |
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