patient_id stringlengths 20 22 | cancer_type stringclasses 1
value | histology stringclasses 2
values | stage_at_diagnosis stringclasses 2
values | molecular_profile dict | baseline_clinical dict | disease_burden_at_dx dict | treatment_course dict | survival_outcomes dict | longitudinal_labs listlengths 3 3 |
|---|---|---|---|---|---|---|---|---|---|
ANODE_SYNTH_2025_9801 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 10,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 7
} | {
"age": 87,
"sex": "male",
"bmi": 33.2,
"smoking_pack_years": 40,
"ecog_performance_status": 1,
"comorbidities": [
"hyperlipidemia"
]
} | {
"primary_tumor_size_cm": 3.4,
"metastatic_sites": [
"brain",
"contralateral lung"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2023-10-16T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -47,
"peak_response_20wk_change_percent": -30
},
"pfs_months": 10.25
},
"second_line_... | {
"overall_survival_months": 14.2,
"censored": false
} | [
{
"date": "2023-09-14T00:00:00",
"hemoglobin_g_dL": 12.5,
"wbc_k_uL": 5.1,
"platelets_k_uL": 434,
"creatinine_mg_dL": 0.86,
"alt_U_L": 14
},
{
"date": "2024-04-13T00:00:00",
"hemoglobin_g_dL": 12.8,
"wbc_k_uL": 4,
"platelets_k_uL": 340,
"creatinine_mg_dL": 1.56,
"... |
ANODE_SYNTH_2025_9802 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 8.7,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 21
} | {
"age": 84,
"sex": "female",
"bmi": 37.2,
"smoking_pack_years": 50,
"ecog_performance_status": 1,
"comorbidities": [
"hypertension",
"diabetes"
]
} | {
"primary_tumor_size_cm": 3.2,
"metastatic_sites": [
"bone",
"pleura"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2022-09-28T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -25,
"peak_response_20wk_change_percent": -80
},
"pfs_months": 47.67
},
"second_line_th... | {
"overall_survival_months": 68.7,
"censored": false
} | [
{
"date": "2022-08-16T00:00:00",
"hemoglobin_g_dL": 13.9,
"wbc_k_uL": 7.1,
"platelets_k_uL": 345,
"creatinine_mg_dL": 1.05,
"alt_U_L": 54
},
{
"date": "2023-03-27T00:00:00",
"hemoglobin_g_dL": 10,
"wbc_k_uL": 6,
"platelets_k_uL": 294,
"creatinine_mg_dL": 1.32,
"al... |
ANODE_SYNTH_2025_9803 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 3.3,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 7
} | {
"age": 59,
"sex": "male",
"bmi": 24.9,
"smoking_pack_years": 14,
"ecog_performance_status": 0,
"comorbidities": [
"hypertension",
"hyperlipidemia"
]
} | {
"primary_tumor_size_cm": 4.6,
"metastatic_sites": [
"pleura"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2024-03-23T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -43,
"peak_response_20wk_change_percent": -51
},
"pfs_months": 41.2
},
"second_line_the... | {
"overall_survival_months": 71.7,
"censored": false
} | [
{
"date": "2024-02-26T00:00:00",
"hemoglobin_g_dL": 13.1,
"wbc_k_uL": 10.1,
"platelets_k_uL": 314,
"creatinine_mg_dL": 0.8,
"alt_U_L": 35
},
{
"date": "2024-09-19T00:00:00",
"hemoglobin_g_dL": 12.6,
"wbc_k_uL": 6.3,
"platelets_k_uL": 276,
"creatinine_mg_dL": 1.11,
... |
ANODE_SYNTH_2025_9804 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 7.1,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 14
} | {
"age": 65,
"sex": "female",
"bmi": 18.6,
"smoking_pack_years": 0,
"ecog_performance_status": 0,
"comorbidities": [
"hyperlipidemia",
"diabetes"
]
} | {
"primary_tumor_size_cm": 5.1,
"metastatic_sites": [
"liver",
"contralateral lung"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2020-06-19T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -33,
"peak_response_20wk_change_percent": -79
},
"pfs_months": 13.47
},
"second_line... | {
"overall_survival_months": 28.5,
"censored": false
} | [
{
"date": "2020-05-25T00:00:00",
"hemoglobin_g_dL": 15.4,
"wbc_k_uL": 10,
"platelets_k_uL": 342,
"creatinine_mg_dL": 0.77,
"alt_U_L": 13
},
{
"date": "2020-12-16T00:00:00",
"hemoglobin_g_dL": 11.4,
"wbc_k_uL": 5,
"platelets_k_uL": 366,
"creatinine_mg_dL": 1.4,
"al... |
ANODE_SYNTH_2025_9805 | Non-small cell lung cancer | Squamous cell carcinoma | IV | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 12.4,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 18
} | {
"age": 80,
"sex": "female",
"bmi": 28.5,
"smoking_pack_years": 28,
"ecog_performance_status": 0,
"comorbidities": []
} | {
"primary_tumor_size_cm": 5.4,
"metastatic_sites": [
"bone",
"pleura"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2023-07-22T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -39,
"peak_response_20wk_change_percent": -85
},
"pfs_months": 17.77
... | {
"overall_survival_months": 26.2,
"censored": false
} | [
{
"date": "2023-05-27T00:00:00",
"hemoglobin_g_dL": 12.8,
"wbc_k_uL": 6.5,
"platelets_k_uL": 315,
"creatinine_mg_dL": 1.24,
"alt_U_L": 23
},
{
"date": "2024-01-18T00:00:00",
"hemoglobin_g_dL": 12.9,
"wbc_k_uL": 7.2,
"platelets_k_uL": 191,
"creatinine_mg_dL": 1.21,
... |
ANODE_SYNTH_2025_9806 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR L858R",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 3.3,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 19
} | {
"age": 70,
"sex": "female",
"bmi": 24.6,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": [
"hyperlipidemia"
]
} | {
"primary_tumor_size_cm": 7.8,
"metastatic_sites": [
"liver",
"pleura"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2024-07-14T00:00:00",
"best_response": "Stable disease",
"radiologic_response": {
"first_ct_8wk_change_percent": -59,
"peak_response_20wk_change_percent": -61
},
"pfs_months": 20.67
},
"second_line_t... | {
"overall_survival_months": 36.2,
"censored": false
} | [
{
"date": "2024-05-13T00:00:00",
"hemoglobin_g_dL": 12.7,
"wbc_k_uL": 10.7,
"platelets_k_uL": 251,
"creatinine_mg_dL": 1.04,
"alt_U_L": 65
},
{
"date": "2025-01-10T00:00:00",
"hemoglobin_g_dL": 10.7,
"wbc_k_uL": 3.8,
"platelets_k_uL": 226,
"creatinine_mg_dL": 1.45,
... |
ANODE_SYNTH_2025_9807 | Non-small cell lung cancer | Squamous cell carcinoma | IVB | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 6.5,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 16
} | {
"age": 59,
"sex": "male",
"bmi": 36,
"smoking_pack_years": 32,
"ecog_performance_status": 1,
"comorbidities": [
"COPD"
]
} | {
"primary_tumor_size_cm": 5.7,
"metastatic_sites": [
"contralateral lung",
"pleura",
"liver"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2025-05-15T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -44,
"peak_response_20wk_change_percent": -63
},
"pfs_months": 23.36
... | {
"overall_survival_months": 32.2,
"censored": false
} | [
{
"date": "2025-04-07T00:00:00",
"hemoglobin_g_dL": 11.7,
"wbc_k_uL": 6.5,
"platelets_k_uL": 404,
"creatinine_mg_dL": 0.63,
"alt_U_L": 73
},
{
"date": "2025-11-11T00:00:00",
"hemoglobin_g_dL": 13.4,
"wbc_k_uL": 4.1,
"platelets_k_uL": 277,
"creatinine_mg_dL": 1.58,
... |
ANODE_SYNTH_2025_9808 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 13.9,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 8
} | {
"age": 78,
"sex": "female",
"bmi": 23.6,
"smoking_pack_years": 58,
"ecog_performance_status": 0,
"comorbidities": [
"hyperlipidemia",
"hypertension"
]
} | {
"primary_tumor_size_cm": 6.6,
"metastatic_sites": [
"contralateral lung"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2024-02-02T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -26,
"peak_response_20wk_change_percent": -79
},
"pfs_months": 46.49
},
"second_line_th... | {
"overall_survival_months": 63.7,
"censored": true
} | [
{
"date": "2024-01-15T00:00:00",
"hemoglobin_g_dL": 12,
"wbc_k_uL": 10.1,
"platelets_k_uL": 181,
"creatinine_mg_dL": 1.1,
"alt_U_L": 46
},
{
"date": "2024-07-31T00:00:00",
"hemoglobin_g_dL": 12.7,
"wbc_k_uL": 4.4,
"platelets_k_uL": 184,
"creatinine_mg_dL": 1.45,
"... |
ANODE_SYNTH_2025_9809 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "EGFR L858R",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 13,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 25
} | {
"age": 75,
"sex": "female",
"bmi": 23.4,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": [
"hyperlipidemia",
"diabetes"
]
} | {
"primary_tumor_size_cm": 7.7,
"metastatic_sites": [
"liver",
"brain"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2026-01-08T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -13,
"peak_response_20wk_change_percent": -62
},
"pfs_months": 23.49
},
"second_line... | {
"overall_survival_months": 40.2,
"censored": false
} | [
{
"date": "2025-12-01T00:00:00",
"hemoglobin_g_dL": 13.5,
"wbc_k_uL": 6.1,
"platelets_k_uL": 235,
"creatinine_mg_dL": 0.88,
"alt_U_L": 29
},
{
"date": "2026-07-07T00:00:00",
"hemoglobin_g_dL": 12.8,
"wbc_k_uL": 6.6,
"platelets_k_uL": 133,
"creatinine_mg_dL": 1.44,
... |
ANODE_SYNTH_2025_9810 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 8.1,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 20
} | {
"age": 60,
"sex": "female",
"bmi": 28.1,
"smoking_pack_years": 0,
"ecog_performance_status": 0,
"comorbidities": [
"COPD",
"hyperlipidemia"
]
} | {
"primary_tumor_size_cm": 3.1,
"metastatic_sites": [
"pleura",
"liver"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2026-01-03T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -13,
"peak_response_20wk_change_percent": -45
},
"pfs_months": 18.1
},
"second_line_... | {
"overall_survival_months": 31.8,
"censored": true
} | [
{
"date": "2025-12-13T00:00:00",
"hemoglobin_g_dL": 15.3,
"wbc_k_uL": 6.8,
"platelets_k_uL": 180,
"creatinine_mg_dL": 1.13,
"alt_U_L": 42
},
{
"date": "2026-07-02T00:00:00",
"hemoglobin_g_dL": 13,
"wbc_k_uL": 8.7,
"platelets_k_uL": 267,
"creatinine_mg_dL": 1.35,
"... |
ANODE_SYNTH_2025_9811 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 4.1,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 11
} | {
"age": 56,
"sex": "female",
"bmi": 22.6,
"smoking_pack_years": 27,
"ecog_performance_status": 1,
"comorbidities": [
"hypertension",
"diabetes"
]
} | {
"primary_tumor_size_cm": 3.1,
"metastatic_sites": [
"bone",
"brain",
"contralateral lung"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2020-02-10T00:00:00",
"best_response": "Stable disease",
"radiologic_response": {
"first_ct_8wk_change_percent": -33,
"peak_response_20wk_change_percent": -32
},
"pfs_months": 47.9
},
"second_line_thera... | {
"overall_survival_months": 72.6,
"censored": false
} | [
{
"date": "2020-01-16T00:00:00",
"hemoglobin_g_dL": 12.7,
"wbc_k_uL": 6.4,
"platelets_k_uL": 151,
"creatinine_mg_dL": 0.64,
"alt_U_L": 38
},
{
"date": "2020-08-08T00:00:00",
"hemoglobin_g_dL": 13,
"wbc_k_uL": 8.7,
"platelets_k_uL": 298,
"creatinine_mg_dL": 1.18,
"... |
ANODE_SYNTH_2025_9812 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 6.8,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 31
} | {
"age": 79,
"sex": "female",
"bmi": 33.2,
"smoking_pack_years": 0,
"ecog_performance_status": 0,
"comorbidities": [
"COPD",
"hypertension"
]
} | {
"primary_tumor_size_cm": 6.6,
"metastatic_sites": [
"bone",
"liver"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2023-05-10T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -25,
"peak_response_20wk_change_percent": -32
},
"pfs_months": 11.7
},
"second_line_... | {
"overall_survival_months": 23.6,
"censored": false
} | [
{
"date": "2023-04-22T00:00:00",
"hemoglobin_g_dL": 14.9,
"wbc_k_uL": 6.8,
"platelets_k_uL": 399,
"creatinine_mg_dL": 0.72,
"alt_U_L": 51
},
{
"date": "2023-11-06T00:00:00",
"hemoglobin_g_dL": 11.4,
"wbc_k_uL": 7.1,
"platelets_k_uL": 157,
"creatinine_mg_dL": 0.98,
... |
ANODE_SYNTH_2025_9813 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 7.6,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 8
} | {
"age": 67,
"sex": "female",
"bmi": 20.2,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": [
"diabetes",
"hyperlipidemia"
]
} | {
"primary_tumor_size_cm": 4.4,
"metastatic_sites": [
"pleura",
"bone",
"contralateral lung"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2020-07-10T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -34,
"peak_response_20wk_change_percent": -37
},
"pfs_months": 28.39
},
"second_line... | {
"overall_survival_months": 39.9,
"censored": false
} | [
{
"date": "2020-06-04T00:00:00",
"hemoglobin_g_dL": 14.7,
"wbc_k_uL": 9.9,
"platelets_k_uL": 390,
"creatinine_mg_dL": 0.66,
"alt_U_L": 63
},
{
"date": "2021-01-06T00:00:00",
"hemoglobin_g_dL": 11,
"wbc_k_uL": 3.9,
"platelets_k_uL": 215,
"creatinine_mg_dL": 1.37,
"... |
ANODE_SYNTH_2025_9814 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 4.7,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 13
} | {
"age": 87,
"sex": "female",
"bmi": 30.2,
"smoking_pack_years": 0,
"ecog_performance_status": 0,
"comorbidities": [
"diabetes"
]
} | {
"primary_tumor_size_cm": 6.9,
"metastatic_sites": [
"brain",
"contralateral lung"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2022-04-27T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -42,
"peak_response_20wk_change_percent": -80
},
"pfs_months": 32.43
},
"second_line... | {
"overall_survival_months": 45.3,
"censored": true
} | [
{
"date": "2022-02-22T00:00:00",
"hemoglobin_g_dL": 14.5,
"wbc_k_uL": 10,
"platelets_k_uL": 281,
"creatinine_mg_dL": 0.78,
"alt_U_L": 41
},
{
"date": "2022-10-24T00:00:00",
"hemoglobin_g_dL": 11.8,
"wbc_k_uL": 4.6,
"platelets_k_uL": 344,
"creatinine_mg_dL": 1.54,
... |
ANODE_SYNTH_2025_9815 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 14.1,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 32
} | {
"age": 68,
"sex": "female",
"bmi": 35.9,
"smoking_pack_years": 65,
"ecog_performance_status": 1,
"comorbidities": [
"diabetes",
"COPD"
]
} | {
"primary_tumor_size_cm": 5.8,
"metastatic_sites": [
"bone"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2024-01-02T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -16,
"peak_response_20wk_change_percent": -49
},
"pfs_months": 39.69
},
"second_line_th... | {
"overall_survival_months": 69.1,
"censored": true
} | [
{
"date": "2023-11-03T00:00:00",
"hemoglobin_g_dL": 14.1,
"wbc_k_uL": 8.5,
"platelets_k_uL": 442,
"creatinine_mg_dL": 0.86,
"alt_U_L": 80
},
{
"date": "2024-06-30T00:00:00",
"hemoglobin_g_dL": 10.3,
"wbc_k_uL": 5.5,
"platelets_k_uL": 198,
"creatinine_mg_dL": 0.89,
... |
ANODE_SYNTH_2025_9816 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 8.1,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 12
} | {
"age": 49,
"sex": "male",
"bmi": 31.8,
"smoking_pack_years": 44,
"ecog_performance_status": 2,
"comorbidities": []
} | {
"primary_tumor_size_cm": 6.2,
"metastatic_sites": [
"contralateral lung"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2023-11-01T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -35,
"peak_response_20wk_change_percent": -65
},
"pfs_months": 11.3
},
"second_line_t... | {
"overall_survival_months": 16.3,
"censored": false
} | [
{
"date": "2023-10-11T00:00:00",
"hemoglobin_g_dL": 12.9,
"wbc_k_uL": 4.6,
"platelets_k_uL": 280,
"creatinine_mg_dL": 1.16,
"alt_U_L": 41
},
{
"date": "2024-04-29T00:00:00",
"hemoglobin_g_dL": 13.2,
"wbc_k_uL": 7.8,
"platelets_k_uL": 195,
"creatinine_mg_dL": 1.45,
... |
ANODE_SYNTH_2025_9817 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 11.6,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 17
} | {
"age": 85,
"sex": "female",
"bmi": 36,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 4.6,
"metastatic_sites": [
"bone",
"liver"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2023-02-18T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -58,
"peak_response_20wk_change_percent": -30
},
"pfs_months": 19.09
},
"second_line... | {
"overall_survival_months": 35,
"censored": false
} | [
{
"date": "2023-01-19T00:00:00",
"hemoglobin_g_dL": 15.4,
"wbc_k_uL": 7.2,
"platelets_k_uL": 192,
"creatinine_mg_dL": 1.03,
"alt_U_L": 24
},
{
"date": "2023-08-17T00:00:00",
"hemoglobin_g_dL": 10.3,
"wbc_k_uL": 8.7,
"platelets_k_uL": 340,
"creatinine_mg_dL": 1.4,
... |
ANODE_SYNTH_2025_9818 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 7,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 18
} | {
"age": 57,
"sex": "female",
"bmi": 28.2,
"smoking_pack_years": 71,
"ecog_performance_status": 0,
"comorbidities": [
"COPD",
"diabetes"
]
} | {
"primary_tumor_size_cm": 5.9,
"metastatic_sites": [
"pleura",
"contralateral lung",
"brain"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2025-12-29T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -37,
"peak_response_20wk_change_percent": -63
},
"pfs_months": 23.29
},
"second_line_... | {
"overall_survival_months": 44.6,
"censored": false
} | [
{
"date": "2025-11-21T00:00:00",
"hemoglobin_g_dL": 14.8,
"wbc_k_uL": 10.3,
"platelets_k_uL": 152,
"creatinine_mg_dL": 0.8,
"alt_U_L": 28
},
{
"date": "2026-06-27T00:00:00",
"hemoglobin_g_dL": 13.7,
"wbc_k_uL": 7.4,
"platelets_k_uL": 370,
"creatinine_mg_dL": 1.53,
... |
ANODE_SYNTH_2025_9819 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 6,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 11
} | {
"age": 85,
"sex": "male",
"bmi": 33.5,
"smoking_pack_years": 59,
"ecog_performance_status": 2,
"comorbidities": []
} | {
"primary_tumor_size_cm": 4.7,
"metastatic_sites": [
"pleura"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2023-03-01T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -19,
"peak_response_20wk_change_percent": -60
},
"pfs_months": 29.7
},
"second_line_the... | {
"overall_survival_months": 60.1,
"censored": false
} | [
{
"date": "2023-01-28T00:00:00",
"hemoglobin_g_dL": 12.9,
"wbc_k_uL": 4.9,
"platelets_k_uL": 394,
"creatinine_mg_dL": 1.2,
"alt_U_L": 21
},
{
"date": "2023-08-28T00:00:00",
"hemoglobin_g_dL": 11.5,
"wbc_k_uL": 8.2,
"platelets_k_uL": 282,
"creatinine_mg_dL": 0.96,
... |
ANODE_SYNTH_2025_9820 | Non-small cell lung cancer | Squamous cell carcinoma | IV | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 15.1,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 29
} | {
"age": 85,
"sex": "female",
"bmi": 22.7,
"smoking_pack_years": 26,
"ecog_performance_status": 2,
"comorbidities": [
"diabetes",
"COPD"
]
} | {
"primary_tumor_size_cm": 3.2,
"metastatic_sites": [
"pleura"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2025-12-18T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -24,
"peak_response_20wk_change_percent": -56
},
"pfs_months": 29.11
... | {
"overall_survival_months": 33.1,
"censored": false
} | [
{
"date": "2025-10-27T00:00:00",
"hemoglobin_g_dL": 12.8,
"wbc_k_uL": 5.7,
"platelets_k_uL": 442,
"creatinine_mg_dL": 1.23,
"alt_U_L": 10
},
{
"date": "2026-06-16T00:00:00",
"hemoglobin_g_dL": 13.2,
"wbc_k_uL": 8.4,
"platelets_k_uL": 294,
"creatinine_mg_dL": 1.45,
... |
ANODE_SYNTH_2025_9821 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 7.7,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 32
} | {
"age": 52,
"sex": "male",
"bmi": 25,
"smoking_pack_years": 68,
"ecog_performance_status": 1,
"comorbidities": [
"COPD"
]
} | {
"primary_tumor_size_cm": 8.2,
"metastatic_sites": [
"brain",
"pleura",
"liver"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2022-03-13T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -19,
"peak_response_20wk_change_percent": -83
},
"pfs_months": 9.2
},
"second_line_th... | {
"overall_survival_months": 13.1,
"censored": true
} | [
{
"date": "2022-02-25T00:00:00",
"hemoglobin_g_dL": 15.1,
"wbc_k_uL": 5.2,
"platelets_k_uL": 421,
"creatinine_mg_dL": 0.83,
"alt_U_L": 12
},
{
"date": "2022-09-09T00:00:00",
"hemoglobin_g_dL": 10.8,
"wbc_k_uL": 7.1,
"platelets_k_uL": 247,
"creatinine_mg_dL": 1.05,
... |
ANODE_SYNTH_2025_9822 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 9.7,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 19
} | {
"age": 76,
"sex": "male",
"bmi": 20.6,
"smoking_pack_years": 18,
"ecog_performance_status": 2,
"comorbidities": []
} | {
"primary_tumor_size_cm": 5.3,
"metastatic_sites": [
"liver",
"contralateral lung"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2021-11-23T00:00:00",
"best_response": "Stable disease",
"radiologic_response": {
"first_ct_8wk_change_percent": -40,
"peak_response_20wk_change_percent": -38
},
"pfs_months": 37.29
},
"second_line_ther... | {
"overall_survival_months": 62.3,
"censored": false
} | [
{
"date": "2021-10-10T00:00:00",
"hemoglobin_g_dL": 14.2,
"wbc_k_uL": 5.4,
"platelets_k_uL": 320,
"creatinine_mg_dL": 1.07,
"alt_U_L": 65
},
{
"date": "2022-05-22T00:00:00",
"hemoglobin_g_dL": 11.9,
"wbc_k_uL": 6.7,
"platelets_k_uL": 319,
"creatinine_mg_dL": 1.56,
... |
ANODE_SYNTH_2025_9823 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 8.4,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 18
} | {
"age": 49,
"sex": "male",
"bmi": 21.8,
"smoking_pack_years": 56,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 4.2,
"metastatic_sites": [
"liver",
"brain",
"contralateral lung"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2025-07-31T00:00:00",
"best_response": "Stable disease",
"radiologic_response": {
"first_ct_8wk_change_percent": -17,
"peak_response_20wk_change_percent": -50
},
"pfs_months": 32.95
},
"second_line_ther... | {
"overall_survival_months": 50.8,
"censored": false
} | [
{
"date": "2025-06-10T00:00:00",
"hemoglobin_g_dL": 14.8,
"wbc_k_uL": 9.3,
"platelets_k_uL": 364,
"creatinine_mg_dL": 0.64,
"alt_U_L": 62
},
{
"date": "2026-01-27T00:00:00",
"hemoglobin_g_dL": 10.9,
"wbc_k_uL": 4.5,
"platelets_k_uL": 222,
"creatinine_mg_dL": 0.93,
... |
ANODE_SYNTH_2025_9824 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 11.3,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 21
} | {
"age": 68,
"sex": "male",
"bmi": 27.7,
"smoking_pack_years": 51,
"ecog_performance_status": 0,
"comorbidities": []
} | {
"primary_tumor_size_cm": 6.9,
"metastatic_sites": [
"bone"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2020-09-20T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -42,
"peak_response_20wk_change_percent": -46
},
"pfs_months": 32.23
},
"second_line_th... | {
"overall_survival_months": 61.9,
"censored": false
} | [
{
"date": "2020-08-08T00:00:00",
"hemoglobin_g_dL": 13.4,
"wbc_k_uL": 10.7,
"platelets_k_uL": 348,
"creatinine_mg_dL": 0.66,
"alt_U_L": 14
},
{
"date": "2021-03-19T00:00:00",
"hemoglobin_g_dL": 12.5,
"wbc_k_uL": 5.1,
"platelets_k_uL": 292,
"creatinine_mg_dL": 1.57,
... |
ANODE_SYNTH_2025_9825 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 13.6,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 13
} | {
"age": 86,
"sex": "male",
"bmi": 35.6,
"smoking_pack_years": 31,
"ecog_performance_status": 1,
"comorbidities": [
"hypertension",
"diabetes"
]
} | {
"primary_tumor_size_cm": 3.1,
"metastatic_sites": [
"bone",
"pleura"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2021-09-15T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -11,
"peak_response_20wk_change_percent": -81
},
"pfs_months": 39.98
},
"second_line_th... | {
"overall_survival_months": 63.9,
"censored": true
} | [
{
"date": "2021-08-13T00:00:00",
"hemoglobin_g_dL": 15,
"wbc_k_uL": 8.7,
"platelets_k_uL": 394,
"creatinine_mg_dL": 0.9,
"alt_U_L": 39
},
{
"date": "2022-03-14T00:00:00",
"hemoglobin_g_dL": 13.2,
"wbc_k_uL": 6.2,
"platelets_k_uL": 223,
"creatinine_mg_dL": 1.05,
"a... |
ANODE_SYNTH_2025_9826 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 9.8,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 33
} | {
"age": 48,
"sex": "female",
"bmi": 21.7,
"smoking_pack_years": 72,
"ecog_performance_status": 1,
"comorbidities": [
"hyperlipidemia"
]
} | {
"primary_tumor_size_cm": 5.7,
"metastatic_sites": [
"contralateral lung"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2025-02-16T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -57,
"peak_response_20wk_change_percent": -85
},
"pfs_months": 41.53
},
"second_line_th... | {
"overall_survival_months": 68.7,
"censored": false
} | [
{
"date": "2025-01-03T00:00:00",
"hemoglobin_g_dL": 15,
"wbc_k_uL": 10.8,
"platelets_k_uL": 310,
"creatinine_mg_dL": 0.94,
"alt_U_L": 13
},
{
"date": "2025-08-15T00:00:00",
"hemoglobin_g_dL": 13.6,
"wbc_k_uL": 8.8,
"platelets_k_uL": 200,
"creatinine_mg_dL": 1.54,
... |
ANODE_SYNTH_2025_9827 | Non-small cell lung cancer | Squamous cell carcinoma | IVB | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 9.4,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 1
} | {
"age": 62,
"sex": "male",
"bmi": 30.9,
"smoking_pack_years": 45,
"ecog_performance_status": 1,
"comorbidities": [
"hypertension"
]
} | {
"primary_tumor_size_cm": 8.3,
"metastatic_sites": [
"bone",
"brain",
"liver"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2020-07-21T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -35,
"peak_response_20wk_change_percent": -80
},
"pfs_months": 9.69
}... | {
"overall_survival_months": 23.2,
"censored": true
} | [
{
"date": "2020-06-10T00:00:00",
"hemoglobin_g_dL": 12.5,
"wbc_k_uL": 5.5,
"platelets_k_uL": 353,
"creatinine_mg_dL": 0.72,
"alt_U_L": 78
},
{
"date": "2021-01-17T00:00:00",
"hemoglobin_g_dL": 12.3,
"wbc_k_uL": 5.1,
"platelets_k_uL": 222,
"creatinine_mg_dL": 0.7,
... |
ANODE_SYNTH_2025_9828 | Non-small cell lung cancer | Squamous cell carcinoma | IVB | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 5,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 9
} | {
"age": 76,
"sex": "male",
"bmi": 19.5,
"smoking_pack_years": 43,
"ecog_performance_status": 1,
"comorbidities": [
"hypertension",
"diabetes"
]
} | {
"primary_tumor_size_cm": 8.4,
"metastatic_sites": [
"pleura",
"liver",
"bone"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2022-10-23T00:00:00",
"best_response": "Stable disease",
"radiologic_response": {
"first_ct_8wk_change_percent": -26,
"peak_response_20wk_change_percent": -75
},
"pfs_months": 21.16
},... | {
"overall_survival_months": 29,
"censored": true
} | [
{
"date": "2022-09-22T00:00:00",
"hemoglobin_g_dL": 14.2,
"wbc_k_uL": 10.4,
"platelets_k_uL": 437,
"creatinine_mg_dL": 0.85,
"alt_U_L": 29
},
{
"date": "2023-04-21T00:00:00",
"hemoglobin_g_dL": 11.8,
"wbc_k_uL": 6.2,
"platelets_k_uL": 238,
"creatinine_mg_dL": 1.14,
... |
ANODE_SYNTH_2025_9829 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR L858R",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 8.8,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 34
} | {
"age": 69,
"sex": "female",
"bmi": 28,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": [
"hypertension",
"hyperlipidemia"
]
} | {
"primary_tumor_size_cm": 7.6,
"metastatic_sites": [
"bone",
"pleura",
"contralateral lung"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2024-04-18T00:00:00",
"best_response": "Stable disease",
"radiologic_response": {
"first_ct_8wk_change_percent": -29,
"peak_response_20wk_change_percent": -60
},
"pfs_months": 19.88
},
"second_line_t... | {
"overall_survival_months": 38.2,
"censored": false
} | [
{
"date": "2024-02-13T00:00:00",
"hemoglobin_g_dL": 14.1,
"wbc_k_uL": 10.9,
"platelets_k_uL": 347,
"creatinine_mg_dL": 1.26,
"alt_U_L": 39
},
{
"date": "2024-10-15T00:00:00",
"hemoglobin_g_dL": 13.6,
"wbc_k_uL": 7.9,
"platelets_k_uL": 139,
"creatinine_mg_dL": 1.3,
... |
ANODE_SYNTH_2025_9830 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "EGFR L858R",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 13.3,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 25
} | {
"age": 65,
"sex": "female",
"bmi": 32.1,
"smoking_pack_years": 0,
"ecog_performance_status": 0,
"comorbidities": [
"hyperlipidemia",
"COPD"
]
} | {
"primary_tumor_size_cm": 3.5,
"metastatic_sites": [
"brain",
"pleura",
"liver"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2021-03-19T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -58,
"peak_response_20wk_change_percent": -44
},
"pfs_months": 24.67
},
"second_line... | {
"overall_survival_months": 44.2,
"censored": false
} | [
{
"date": "2021-01-16T00:00:00",
"hemoglobin_g_dL": 12.4,
"wbc_k_uL": 8.8,
"platelets_k_uL": 382,
"creatinine_mg_dL": 1.27,
"alt_U_L": 39
},
{
"date": "2021-09-15T00:00:00",
"hemoglobin_g_dL": 12.8,
"wbc_k_uL": 8.3,
"platelets_k_uL": 314,
"creatinine_mg_dL": 0.98,
... |
ANODE_SYNTH_2025_9831 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 10.1,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 33
} | {
"age": 80,
"sex": "female",
"bmi": 24,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": [
"COPD",
"diabetes"
]
} | {
"primary_tumor_size_cm": 5.1,
"metastatic_sites": [
"pleura",
"brain",
"bone"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2020-03-22T00:00:00",
"best_response": "Stable disease",
"radiologic_response": {
"first_ct_8wk_change_percent": -50,
"peak_response_20wk_change_percent": -79
},
"pfs_months": 23.75
},
"second_line_t... | {
"overall_survival_months": 31.1,
"censored": false
} | [
{
"date": "2020-02-18T00:00:00",
"hemoglobin_g_dL": 12.4,
"wbc_k_uL": 8.4,
"platelets_k_uL": 183,
"creatinine_mg_dL": 0.67,
"alt_U_L": 43
},
{
"date": "2020-09-18T00:00:00",
"hemoglobin_g_dL": 11.3,
"wbc_k_uL": 5.3,
"platelets_k_uL": 153,
"creatinine_mg_dL": 1.57,
... |
ANODE_SYNTH_2025_9832 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 4.2,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 15
} | {
"age": 67,
"sex": "female",
"bmi": 32.1,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": [
"diabetes",
"COPD"
]
} | {
"primary_tumor_size_cm": 7.3,
"metastatic_sites": [
"contralateral lung",
"pleura",
"bone"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2023-08-02T00:00:00",
"best_response": "Stable disease",
"radiologic_response": {
"first_ct_8wk_change_percent": -31,
"peak_response_20wk_change_percent": -50
},
"pfs_months": 31.57
},
"second_line_t... | {
"overall_survival_months": 44.1,
"censored": false
} | [
{
"date": "2023-06-23T00:00:00",
"hemoglobin_g_dL": 12,
"wbc_k_uL": 6.7,
"platelets_k_uL": 258,
"creatinine_mg_dL": 1.14,
"alt_U_L": 36
},
{
"date": "2024-01-29T00:00:00",
"hemoglobin_g_dL": 12.7,
"wbc_k_uL": 6.4,
"platelets_k_uL": 208,
"creatinine_mg_dL": 0.84,
"... |
ANODE_SYNTH_2025_9833 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 13.9,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 16
} | {
"age": 76,
"sex": "male",
"bmi": 32.5,
"smoking_pack_years": 28,
"ecog_performance_status": 1,
"comorbidities": [
"diabetes"
]
} | {
"primary_tumor_size_cm": 5.7,
"metastatic_sites": [
"bone",
"brain",
"liver"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2025-01-17T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -19,
"peak_response_20wk_change_percent": -66
},
"pfs_months": 3.45
},
"second_line_t... | {
"overall_survival_months": 11.6,
"censored": true
} | [
{
"date": "2024-11-20T00:00:00",
"hemoglobin_g_dL": 12.7,
"wbc_k_uL": 9.4,
"platelets_k_uL": 225,
"creatinine_mg_dL": 1.06,
"alt_U_L": 24
},
{
"date": "2025-07-16T00:00:00",
"hemoglobin_g_dL": 11.8,
"wbc_k_uL": 6,
"platelets_k_uL": 269,
"creatinine_mg_dL": 0.78,
"... |
ANODE_SYNTH_2025_9834 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 2.6,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 29
} | {
"age": 77,
"sex": "female",
"bmi": 18.8,
"smoking_pack_years": 39,
"ecog_performance_status": 0,
"comorbidities": [
"hyperlipidemia"
]
} | {
"primary_tumor_size_cm": 5.3,
"metastatic_sites": [
"contralateral lung",
"bone",
"liver"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2022-07-31T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -48,
"peak_response_20wk_change_percent": -85
},
"pfs_months": 2.96
},
"second_line_t... | {
"overall_survival_months": 18.1,
"censored": false
} | [
{
"date": "2022-06-05T00:00:00",
"hemoglobin_g_dL": 13.3,
"wbc_k_uL": 6.2,
"platelets_k_uL": 231,
"creatinine_mg_dL": 0.76,
"alt_U_L": 25
},
{
"date": "2023-01-27T00:00:00",
"hemoglobin_g_dL": 13.2,
"wbc_k_uL": 3.9,
"platelets_k_uL": 136,
"creatinine_mg_dL": 1.48,
... |
ANODE_SYNTH_2025_9835 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 16.2,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 31
} | {
"age": 84,
"sex": "female",
"bmi": 24.8,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": [
"hyperlipidemia",
"diabetes"
]
} | {
"primary_tumor_size_cm": 4.5,
"metastatic_sites": [
"bone",
"brain",
"contralateral lung"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2025-04-26T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -54,
"peak_response_20wk_change_percent": -30
},
"pfs_months": 14.85
},
"second_line... | {
"overall_survival_months": 30.1,
"censored": false
} | [
{
"date": "2025-04-08T00:00:00",
"hemoglobin_g_dL": 13.2,
"wbc_k_uL": 5.5,
"platelets_k_uL": 440,
"creatinine_mg_dL": 1.14,
"alt_U_L": 38
},
{
"date": "2025-10-23T00:00:00",
"hemoglobin_g_dL": 14,
"wbc_k_uL": 6.5,
"platelets_k_uL": 376,
"creatinine_mg_dL": 1.2,
"a... |
ANODE_SYNTH_2025_9836 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 7,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 28
} | {
"age": 49,
"sex": "female",
"bmi": 36.6,
"smoking_pack_years": 0,
"ecog_performance_status": 0,
"comorbidities": []
} | {
"primary_tumor_size_cm": 3.3,
"metastatic_sites": [
"brain"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2022-05-22T00:00:00",
"best_response": "Stable disease",
"radiologic_response": {
"first_ct_8wk_change_percent": -45,
"peak_response_20wk_change_percent": -32
},
"pfs_months": 22.87
},
"second_line_t... | {
"overall_survival_months": 44.1,
"censored": false
} | [
{
"date": "2022-04-18T00:00:00",
"hemoglobin_g_dL": 13.4,
"wbc_k_uL": 9.1,
"platelets_k_uL": 434,
"creatinine_mg_dL": 0.76,
"alt_U_L": 45
},
{
"date": "2022-11-18T00:00:00",
"hemoglobin_g_dL": 11.2,
"wbc_k_uL": 6.2,
"platelets_k_uL": 252,
"creatinine_mg_dL": 1.07,
... |
ANODE_SYNTH_2025_9837 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 5,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 18
} | {
"age": 51,
"sex": "male",
"bmi": 21.1,
"smoking_pack_years": 35,
"ecog_performance_status": 0,
"comorbidities": [
"hypertension",
"diabetes"
]
} | {
"primary_tumor_size_cm": 5.9,
"metastatic_sites": [
"bone",
"liver",
"pleura"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2020-04-12T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -16,
"peak_response_20wk_change_percent": -83
},
"pfs_months": 38.28
},
"second_line_th... | {
"overall_survival_months": 64,
"censored": false
} | [
{
"date": "2020-02-28T00:00:00",
"hemoglobin_g_dL": 11.6,
"wbc_k_uL": 10.3,
"platelets_k_uL": 373,
"creatinine_mg_dL": 1.09,
"alt_U_L": 62
},
{
"date": "2020-10-09T00:00:00",
"hemoglobin_g_dL": 11.8,
"wbc_k_uL": 7.7,
"platelets_k_uL": 332,
"creatinine_mg_dL": 1.46,
... |
ANODE_SYNTH_2025_9838 | Non-small cell lung cancer | Squamous cell carcinoma | IV | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 14.5,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 29
} | {
"age": 72,
"sex": "male",
"bmi": 19.4,
"smoking_pack_years": 58,
"ecog_performance_status": 1,
"comorbidities": [
"diabetes",
"hypertension"
]
} | {
"primary_tumor_size_cm": 7.9,
"metastatic_sites": [
"contralateral lung",
"liver"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2021-07-01T00:00:00",
"best_response": "Stable disease",
"radiologic_response": {
"first_ct_8wk_change_percent": -55,
"peak_response_20wk_change_percent": -68
},
"pfs_months": 26.55
},... | {
"overall_survival_months": 30.5,
"censored": false
} | [
{
"date": "2021-05-04T00:00:00",
"hemoglobin_g_dL": 12,
"wbc_k_uL": 8.5,
"platelets_k_uL": 251,
"creatinine_mg_dL": 1.12,
"alt_U_L": 31
},
{
"date": "2021-12-28T00:00:00",
"hemoglobin_g_dL": 10.4,
"wbc_k_uL": 6.4,
"platelets_k_uL": 301,
"creatinine_mg_dL": 1.2,
"a... |
ANODE_SYNTH_2025_9839 | Non-small cell lung cancer | Squamous cell carcinoma | IV | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 11.2,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 33
} | {
"age": 82,
"sex": "female",
"bmi": 35.7,
"smoking_pack_years": 73,
"ecog_performance_status": 0,
"comorbidities": []
} | {
"primary_tumor_size_cm": 3.6,
"metastatic_sites": [
"contralateral lung"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2025-05-14T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -54,
"peak_response_20wk_change_percent": -68
},
"pfs_months": 23.82
... | {
"overall_survival_months": 42,
"censored": false
} | [
{
"date": "2025-04-27T00:00:00",
"hemoglobin_g_dL": 13.2,
"wbc_k_uL": 9.3,
"platelets_k_uL": 226,
"creatinine_mg_dL": 0.83,
"alt_U_L": 35
},
{
"date": "2025-11-10T00:00:00",
"hemoglobin_g_dL": 11.6,
"wbc_k_uL": 6.7,
"platelets_k_uL": 161,
"creatinine_mg_dL": 1.2,
... |
ANODE_SYNTH_2025_9840 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 3,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 18
} | {
"age": 74,
"sex": "female",
"bmi": 34.5,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": [
"hypertension",
"COPD"
]
} | {
"primary_tumor_size_cm": 7.7,
"metastatic_sites": [
"brain"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2020-06-29T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -37,
"peak_response_20wk_change_percent": -50
},
"pfs_months": 16.2
},
"second_line_... | {
"overall_survival_months": 36.4,
"censored": false
} | [
{
"date": "2020-06-12T00:00:00",
"hemoglobin_g_dL": 13.9,
"wbc_k_uL": 8.5,
"platelets_k_uL": 414,
"creatinine_mg_dL": 1.18,
"alt_U_L": 17
},
{
"date": "2020-12-26T00:00:00",
"hemoglobin_g_dL": 10.4,
"wbc_k_uL": 4.6,
"platelets_k_uL": 353,
"creatinine_mg_dL": 0.95,
... |
ANODE_SYNTH_2025_9841 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "EGFR L858R",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 5.8,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 20
} | {
"age": 72,
"sex": "female",
"bmi": 28.4,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 6.8,
"metastatic_sites": [
"brain"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2023-03-23T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -36,
"peak_response_20wk_change_percent": -82
},
"pfs_months": 20.21
},
"second_line... | {
"overall_survival_months": 37.9,
"censored": false
} | [
{
"date": "2023-02-22T00:00:00",
"hemoglobin_g_dL": 14.6,
"wbc_k_uL": 9.8,
"platelets_k_uL": 220,
"creatinine_mg_dL": 0.76,
"alt_U_L": 73
},
{
"date": "2023-09-19T00:00:00",
"hemoglobin_g_dL": 12,
"wbc_k_uL": 8,
"platelets_k_uL": 245,
"creatinine_mg_dL": 0.75,
"al... |
ANODE_SYNTH_2025_9842 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 17.9,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 5
} | {
"age": 60,
"sex": "male",
"bmi": 24.2,
"smoking_pack_years": 22,
"ecog_performance_status": 1,
"comorbidities": [
"diabetes",
"hypertension"
]
} | {
"primary_tumor_size_cm": 3.2,
"metastatic_sites": [
"brain",
"pleura",
"liver"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2020-12-18T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -27,
"peak_response_20wk_change_percent": -55
},
"pfs_months": 40.34
},
"second_line_th... | {
"overall_survival_months": 69.6,
"censored": false
} | [
{
"date": "2020-10-20T00:00:00",
"hemoglobin_g_dL": 12.2,
"wbc_k_uL": 7,
"platelets_k_uL": 320,
"creatinine_mg_dL": 1.18,
"alt_U_L": 75
},
{
"date": "2021-06-16T00:00:00",
"hemoglobin_g_dL": 12.8,
"wbc_k_uL": 4.4,
"platelets_k_uL": 137,
"creatinine_mg_dL": 1.13,
"... |
ANODE_SYNTH_2025_9843 | Non-small cell lung cancer | Squamous cell carcinoma | IV | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 5.2,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 2
} | {
"age": 58,
"sex": "female",
"bmi": 23.7,
"smoking_pack_years": 35,
"ecog_performance_status": 2,
"comorbidities": [
"hyperlipidemia"
]
} | {
"primary_tumor_size_cm": 4.7,
"metastatic_sites": [
"liver",
"brain"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2025-02-13T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -31,
"peak_response_20wk_change_percent": -31
},
"pfs_months": 33.41
... | {
"overall_survival_months": 42.9,
"censored": true
} | [
{
"date": "2025-01-17T00:00:00",
"hemoglobin_g_dL": 12.9,
"wbc_k_uL": 11,
"platelets_k_uL": 211,
"creatinine_mg_dL": 0.94,
"alt_U_L": 34
},
{
"date": "2025-08-12T00:00:00",
"hemoglobin_g_dL": 13.6,
"wbc_k_uL": 6.7,
"platelets_k_uL": 189,
"creatinine_mg_dL": 0.93,
... |
ANODE_SYNTH_2025_9844 | Non-small cell lung cancer | Squamous cell carcinoma | IV | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 7.5,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 2
} | {
"age": 62,
"sex": "male",
"bmi": 27.2,
"smoking_pack_years": 56,
"ecog_performance_status": 0,
"comorbidities": [
"COPD",
"hyperlipidemia"
]
} | {
"primary_tumor_size_cm": 5.1,
"metastatic_sites": [
"liver"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2023-03-09T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -28,
"peak_response_20wk_change_percent": -32
},
"pfs_months": 17.31
... | {
"overall_survival_months": 23.1,
"censored": false
} | [
{
"date": "2023-01-08T00:00:00",
"hemoglobin_g_dL": 14,
"wbc_k_uL": 7.1,
"platelets_k_uL": 400,
"creatinine_mg_dL": 1,
"alt_U_L": 69
},
{
"date": "2023-09-05T00:00:00",
"hemoglobin_g_dL": 11.7,
"wbc_k_uL": 7.6,
"platelets_k_uL": 176,
"creatinine_mg_dL": 0.94,
"alt... |
ANODE_SYNTH_2025_9845 | Non-small cell lung cancer | Squamous cell carcinoma | IV | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 8.2,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 5
} | {
"age": 81,
"sex": "male",
"bmi": 23.9,
"smoking_pack_years": 50,
"ecog_performance_status": 1,
"comorbidities": [
"diabetes"
]
} | {
"primary_tumor_size_cm": 6.6,
"metastatic_sites": [
"liver",
"brain",
"pleura"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2023-11-10T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -48,
"peak_response_20wk_change_percent": -73
},
"pfs_months": 32.07
... | {
"overall_survival_months": 41.9,
"censored": true
} | [
{
"date": "2023-10-12T00:00:00",
"hemoglobin_g_dL": 15.3,
"wbc_k_uL": 6.5,
"platelets_k_uL": 437,
"creatinine_mg_dL": 0.72,
"alt_U_L": 80
},
{
"date": "2024-05-08T00:00:00",
"hemoglobin_g_dL": 13.6,
"wbc_k_uL": 3.8,
"platelets_k_uL": 363,
"creatinine_mg_dL": 1.38,
... |
ANODE_SYNTH_2025_9846 | Non-small cell lung cancer | Squamous cell carcinoma | IV | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 3.7,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 14
} | {
"age": 66,
"sex": "male",
"bmi": 34.5,
"smoking_pack_years": 23,
"ecog_performance_status": 1,
"comorbidities": [
"hyperlipidemia"
]
} | {
"primary_tumor_size_cm": 5.4,
"metastatic_sites": [
"brain",
"pleura",
"contralateral lung"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2022-12-26T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -23,
"peak_response_20wk_change_percent": -41
},
"pfs_months": 21.49
... | {
"overall_survival_months": 38.5,
"censored": true
} | [
{
"date": "2022-11-03T00:00:00",
"hemoglobin_g_dL": 12,
"wbc_k_uL": 8.3,
"platelets_k_uL": 286,
"creatinine_mg_dL": 1.01,
"alt_U_L": 50
},
{
"date": "2023-06-24T00:00:00",
"hemoglobin_g_dL": 13.3,
"wbc_k_uL": 5,
"platelets_k_uL": 209,
"creatinine_mg_dL": 1.15,
"al... |
ANODE_SYNTH_2025_9847 | Non-small cell lung cancer | Squamous cell carcinoma | IV | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 17.3,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 0
} | {
"age": 66,
"sex": "female",
"bmi": 29.9,
"smoking_pack_years": 29,
"ecog_performance_status": 0,
"comorbidities": []
} | {
"primary_tumor_size_cm": 7.6,
"metastatic_sites": [
"bone",
"pleura",
"liver"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2024-06-17T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -51,
"peak_response_20wk_change_percent": -38
},
"pfs_months": 28.75
... | {
"overall_survival_months": 46.9,
"censored": false
} | [
{
"date": "2024-05-22T00:00:00",
"hemoglobin_g_dL": 14.1,
"wbc_k_uL": 8.5,
"platelets_k_uL": 259,
"creatinine_mg_dL": 1.04,
"alt_U_L": 39
},
{
"date": "2024-12-14T00:00:00",
"hemoglobin_g_dL": 10.6,
"wbc_k_uL": 4.3,
"platelets_k_uL": 317,
"creatinine_mg_dL": 1.06,
... |
ANODE_SYNTH_2025_9848 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR L858R",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 11.5,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 21
} | {
"age": 87,
"sex": "female",
"bmi": 21.4,
"smoking_pack_years": 0,
"ecog_performance_status": 0,
"comorbidities": [
"hypertension",
"COPD"
]
} | {
"primary_tumor_size_cm": 3,
"metastatic_sites": [
"bone",
"contralateral lung"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2025-02-18T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -27,
"peak_response_20wk_change_percent": -73
},
"pfs_months": 24.87
},
"second_line... | {
"overall_survival_months": 36,
"censored": false
} | [
{
"date": "2025-01-18T00:00:00",
"hemoglobin_g_dL": 11.9,
"wbc_k_uL": 4.9,
"platelets_k_uL": 273,
"creatinine_mg_dL": 0.8,
"alt_U_L": 59
},
{
"date": "2025-08-17T00:00:00",
"hemoglobin_g_dL": 12.9,
"wbc_k_uL": 7,
"platelets_k_uL": 311,
"creatinine_mg_dL": 0.76,
"a... |
ANODE_SYNTH_2025_9849 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 14.7,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 25
} | {
"age": 77,
"sex": "female",
"bmi": 30.9,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 4.4,
"metastatic_sites": [
"contralateral lung"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2022-03-03T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -17,
"peak_response_20wk_change_percent": -77
},
"pfs_months": 28.65
},
"second_line... | {
"overall_survival_months": 44.4,
"censored": false
} | [
{
"date": "2022-01-09T00:00:00",
"hemoglobin_g_dL": 13.8,
"wbc_k_uL": 8.6,
"platelets_k_uL": 298,
"creatinine_mg_dL": 0.68,
"alt_U_L": 12
},
{
"date": "2022-08-30T00:00:00",
"hemoglobin_g_dL": 13,
"wbc_k_uL": 6.8,
"platelets_k_uL": 317,
"creatinine_mg_dL": 1.32,
"... |
ANODE_SYNTH_2025_9850 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 16.2,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 9
} | {
"age": 87,
"sex": "female",
"bmi": 37.2,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": [
"hypertension",
"diabetes"
]
} | {
"primary_tumor_size_cm": 4.9,
"metastatic_sites": [
"brain"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2020-05-27T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -32,
"peak_response_20wk_change_percent": -52
},
"pfs_months": 20.67
},
"second_line... | {
"overall_survival_months": 39.5,
"censored": false
} | [
{
"date": "2020-05-10T00:00:00",
"hemoglobin_g_dL": 12.3,
"wbc_k_uL": 9.3,
"platelets_k_uL": 397,
"creatinine_mg_dL": 0.73,
"alt_U_L": 23
},
{
"date": "2020-11-23T00:00:00",
"hemoglobin_g_dL": 10.9,
"wbc_k_uL": 4.7,
"platelets_k_uL": 188,
"creatinine_mg_dL": 1.39,
... |
ANODE_SYNTH_2025_9851 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 6,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 35
} | {
"age": 81,
"sex": "female",
"bmi": 21.8,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": [
"COPD"
]
} | {
"primary_tumor_size_cm": 7.8,
"metastatic_sites": [
"pleura",
"brain",
"liver"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2025-03-15T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -37,
"peak_response_20wk_change_percent": -70
},
"pfs_months": 21.75
},
"second_line... | {
"overall_survival_months": 34.6,
"censored": true
} | [
{
"date": "2025-02-09T00:00:00",
"hemoglobin_g_dL": 12.5,
"wbc_k_uL": 8.2,
"platelets_k_uL": 255,
"creatinine_mg_dL": 1.25,
"alt_U_L": 25
},
{
"date": "2025-09-11T00:00:00",
"hemoglobin_g_dL": 11.9,
"wbc_k_uL": 8.5,
"platelets_k_uL": 140,
"creatinine_mg_dL": 1.56,
... |
ANODE_SYNTH_2025_9852 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 12.8,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 25
} | {
"age": 70,
"sex": "female",
"bmi": 35.1,
"smoking_pack_years": 0,
"ecog_performance_status": 0,
"comorbidities": [
"diabetes",
"hyperlipidemia"
]
} | {
"primary_tumor_size_cm": 5.9,
"metastatic_sites": [
"pleura",
"bone"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2020-11-06T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -22,
"peak_response_20wk_change_percent": -47
},
"pfs_months": 15.15
},
"second_line... | {
"overall_survival_months": 35.9,
"censored": false
} | [
{
"date": "2020-10-01T00:00:00",
"hemoglobin_g_dL": 14,
"wbc_k_uL": 5.9,
"platelets_k_uL": 349,
"creatinine_mg_dL": 1.16,
"alt_U_L": 45
},
{
"date": "2021-05-05T00:00:00",
"hemoglobin_g_dL": 11.6,
"wbc_k_uL": 8,
"platelets_k_uL": 359,
"creatinine_mg_dL": 0.84,
"al... |
ANODE_SYNTH_2025_9853 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 6.5,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 5
} | {
"age": 51,
"sex": "female",
"bmi": 27.9,
"smoking_pack_years": 51,
"ecog_performance_status": 1,
"comorbidities": [
"COPD"
]
} | {
"primary_tumor_size_cm": 3.3,
"metastatic_sites": [
"brain",
"contralateral lung"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2023-10-02T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -33,
"peak_response_20wk_change_percent": -56
},
"pfs_months": 7.33
},
"second_line_t... | {
"overall_survival_months": 26.5,
"censored": true
} | [
{
"date": "2023-09-16T00:00:00",
"hemoglobin_g_dL": 13.1,
"wbc_k_uL": 10.5,
"platelets_k_uL": 258,
"creatinine_mg_dL": 1.01,
"alt_U_L": 61
},
{
"date": "2024-03-30T00:00:00",
"hemoglobin_g_dL": 10.2,
"wbc_k_uL": 5.2,
"platelets_k_uL": 124,
"creatinine_mg_dL": 1.13,
... |
ANODE_SYNTH_2025_9854 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 11.5,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 25
} | {
"age": 81,
"sex": "male",
"bmi": 19.7,
"smoking_pack_years": 26,
"ecog_performance_status": 0,
"comorbidities": [
"COPD",
"hypertension"
]
} | {
"primary_tumor_size_cm": 4.2,
"metastatic_sites": [
"contralateral lung",
"brain",
"bone"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2023-09-20T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -43,
"peak_response_20wk_change_percent": -70
},
"pfs_months": 20.67
},
"second_line_... | {
"overall_survival_months": 27,
"censored": false
} | [
{
"date": "2023-08-22T00:00:00",
"hemoglobin_g_dL": 11.9,
"wbc_k_uL": 10.7,
"platelets_k_uL": 268,
"creatinine_mg_dL": 1.23,
"alt_U_L": 56
},
{
"date": "2024-03-18T00:00:00",
"hemoglobin_g_dL": 12.7,
"wbc_k_uL": 5.1,
"platelets_k_uL": 208,
"creatinine_mg_dL": 1.37,
... |
ANODE_SYNTH_2025_9855 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 2.9,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 3
} | {
"age": 68,
"sex": "female",
"bmi": 19,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": [
"COPD"
]
} | {
"primary_tumor_size_cm": 3.6,
"metastatic_sites": [
"contralateral lung",
"liver",
"pleura"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2022-12-01T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -24,
"peak_response_20wk_change_percent": -80
},
"pfs_months": 20.73
},
"second_line... | {
"overall_survival_months": 37,
"censored": false
} | [
{
"date": "2022-10-05T00:00:00",
"hemoglobin_g_dL": 14.9,
"wbc_k_uL": 7.1,
"platelets_k_uL": 295,
"creatinine_mg_dL": 1.13,
"alt_U_L": 27
},
{
"date": "2023-05-30T00:00:00",
"hemoglobin_g_dL": 12.7,
"wbc_k_uL": 7,
"platelets_k_uL": 356,
"creatinine_mg_dL": 1.02,
"... |
ANODE_SYNTH_2025_9856 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 9.1,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 0
} | {
"age": 62,
"sex": "male",
"bmi": 20.3,
"smoking_pack_years": 51,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 4.7,
"metastatic_sites": [
"contralateral lung",
"liver"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2025-09-21T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -49,
"peak_response_20wk_change_percent": -82
},
"pfs_months": 2.96
},
"second_line_t... | {
"overall_survival_months": 19.7,
"censored": false
} | [
{
"date": "2025-08-13T00:00:00",
"hemoglobin_g_dL": 12.8,
"wbc_k_uL": 5.5,
"platelets_k_uL": 152,
"creatinine_mg_dL": 0.63,
"alt_U_L": 60
},
{
"date": "2026-03-20T00:00:00",
"hemoglobin_g_dL": 10.8,
"wbc_k_uL": 4.6,
"platelets_k_uL": 143,
"creatinine_mg_dL": 0.79,
... |
ANODE_SYNTH_2025_9857 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 3.9,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 14
} | {
"age": 64,
"sex": "male",
"bmi": 19.1,
"smoking_pack_years": 40,
"ecog_performance_status": 2,
"comorbidities": [
"diabetes"
]
} | {
"primary_tumor_size_cm": 4.2,
"metastatic_sites": [
"pleura",
"liver",
"contralateral lung"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2020-05-08T00:00:00",
"best_response": "Stable disease",
"radiologic_response": {
"first_ct_8wk_change_percent": -11,
"peak_response_20wk_change_percent": -71
},
"pfs_months": 20.14
},
"second_line_th... | {
"overall_survival_months": 30.8,
"censored": false
} | [
{
"date": "2020-03-18T00:00:00",
"hemoglobin_g_dL": 13,
"wbc_k_uL": 10.9,
"platelets_k_uL": 279,
"creatinine_mg_dL": 1.22,
"alt_U_L": 32
},
{
"date": "2020-11-04T00:00:00",
"hemoglobin_g_dL": 13.1,
"wbc_k_uL": 5.5,
"platelets_k_uL": 338,
"creatinine_mg_dL": 0.84,
... |
ANODE_SYNTH_2025_9858 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 5.1,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 29
} | {
"age": 63,
"sex": "female",
"bmi": 25.5,
"smoking_pack_years": 72,
"ecog_performance_status": 1,
"comorbidities": [
"hyperlipidemia"
]
} | {
"primary_tumor_size_cm": 3.8,
"metastatic_sites": [
"brain",
"pleura"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2023-04-29T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -42,
"peak_response_20wk_change_percent": -68
},
"pfs_months": 9.72
},
"second_line_t... | {
"overall_survival_months": 19.4,
"censored": false
} | [
{
"date": "2023-03-20T00:00:00",
"hemoglobin_g_dL": 12.8,
"wbc_k_uL": 6.1,
"platelets_k_uL": 228,
"creatinine_mg_dL": 0.85,
"alt_U_L": 30
},
{
"date": "2023-10-26T00:00:00",
"hemoglobin_g_dL": 12,
"wbc_k_uL": 6.1,
"platelets_k_uL": 198,
"creatinine_mg_dL": 0.85,
"... |
ANODE_SYNTH_2025_9859 | Non-small cell lung cancer | Squamous cell carcinoma | IVB | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 7.2,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 20
} | {
"age": 61,
"sex": "male",
"bmi": 30.2,
"smoking_pack_years": 34,
"ecog_performance_status": 1,
"comorbidities": [
"hyperlipidemia"
]
} | {
"primary_tumor_size_cm": 6.4,
"metastatic_sites": [
"bone",
"pleura",
"brain"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2022-06-29T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -18,
"peak_response_20wk_change_percent": -54
},
"pfs_months": 14.49
... | {
"overall_survival_months": 29.3,
"censored": true
} | [
{
"date": "2022-05-05T00:00:00",
"hemoglobin_g_dL": 12.5,
"wbc_k_uL": 9.2,
"platelets_k_uL": 293,
"creatinine_mg_dL": 1,
"alt_U_L": 60
},
{
"date": "2022-12-26T00:00:00",
"hemoglobin_g_dL": 10.1,
"wbc_k_uL": 4.5,
"platelets_k_uL": 320,
"creatinine_mg_dL": 1.14,
"a... |
ANODE_SYNTH_2025_9860 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 14.2,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 16
} | {
"age": 68,
"sex": "female",
"bmi": 28.1,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 4.8,
"metastatic_sites": [
"brain"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2025-12-26T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -18,
"peak_response_20wk_change_percent": -65
},
"pfs_months": 29.27
},
"second_line... | {
"overall_survival_months": 44.1,
"censored": true
} | [
{
"date": "2025-10-20T00:00:00",
"hemoglobin_g_dL": 15.5,
"wbc_k_uL": 7.6,
"platelets_k_uL": 253,
"creatinine_mg_dL": 0.74,
"alt_U_L": 31
},
{
"date": "2026-06-24T00:00:00",
"hemoglobin_g_dL": 11.9,
"wbc_k_uL": 4.9,
"platelets_k_uL": 312,
"creatinine_mg_dL": 0.84,
... |
ANODE_SYNTH_2025_9861 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "EGFR L858R",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 6.8,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 9
} | {
"age": 54,
"sex": "female",
"bmi": 27,
"smoking_pack_years": 0,
"ecog_performance_status": 2,
"comorbidities": [
"hyperlipidemia"
]
} | {
"primary_tumor_size_cm": 6.5,
"metastatic_sites": [
"contralateral lung"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2025-12-27T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -27,
"peak_response_20wk_change_percent": -38
},
"pfs_months": 20.44
},
"second_line... | {
"overall_survival_months": 36,
"censored": false
} | [
{
"date": "2025-10-21T00:00:00",
"hemoglobin_g_dL": 12.9,
"wbc_k_uL": 7,
"platelets_k_uL": 214,
"creatinine_mg_dL": 1.05,
"alt_U_L": 37
},
{
"date": "2026-06-25T00:00:00",
"hemoglobin_g_dL": 11.9,
"wbc_k_uL": 5.8,
"platelets_k_uL": 315,
"creatinine_mg_dL": 1.37,
"... |
ANODE_SYNTH_2025_9862 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 6.2,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 27
} | {
"age": 68,
"sex": "female",
"bmi": 23.4,
"smoking_pack_years": 57,
"ecog_performance_status": 0,
"comorbidities": []
} | {
"primary_tumor_size_cm": 5.6,
"metastatic_sites": [
"contralateral lung"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2022-08-19T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -20,
"peak_response_20wk_change_percent": -50
},
"pfs_months": 34.43
},
"second_line_th... | {
"overall_survival_months": 52.4,
"censored": false
} | [
{
"date": "2022-07-09T00:00:00",
"hemoglobin_g_dL": 15.3,
"wbc_k_uL": 9.1,
"platelets_k_uL": 358,
"creatinine_mg_dL": 1.17,
"alt_U_L": 32
},
{
"date": "2023-02-15T00:00:00",
"hemoglobin_g_dL": 10.4,
"wbc_k_uL": 8.2,
"platelets_k_uL": 325,
"creatinine_mg_dL": 1.3,
... |
ANODE_SYNTH_2025_9863 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "NTRK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 13.7,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 33
} | {
"age": 55,
"sex": "male",
"bmi": 26.1,
"smoking_pack_years": 68,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 7.2,
"metastatic_sites": [
"contralateral lung",
"liver"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "larotrectinib 100 mg BID",
"start_date": "2023-10-06T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -33,
"peak_response_20wk_change_percent": -79
},
"pfs_months": 13.67
},
"second_lin... | {
"overall_survival_months": 17.6,
"censored": false
} | [
{
"date": "2023-09-07T00:00:00",
"hemoglobin_g_dL": 15.3,
"wbc_k_uL": 6.4,
"platelets_k_uL": 331,
"creatinine_mg_dL": 1.11,
"alt_U_L": 80
},
{
"date": "2024-04-03T00:00:00",
"hemoglobin_g_dL": 13.8,
"wbc_k_uL": 8.7,
"platelets_k_uL": 168,
"creatinine_mg_dL": 1.04,
... |
ANODE_SYNTH_2025_9864 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 15.4,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 35
} | {
"age": 69,
"sex": "male",
"bmi": 29.9,
"smoking_pack_years": 63,
"ecog_performance_status": 1,
"comorbidities": [
"diabetes",
"hypertension"
]
} | {
"primary_tumor_size_cm": 3.8,
"metastatic_sites": [
"pleura",
"brain"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2025-09-24T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -14,
"peak_response_20wk_change_percent": -70
},
"pfs_months": 39.29
},
"second_line_th... | {
"overall_survival_months": 55.4,
"censored": true
} | [
{
"date": "2025-08-07T00:00:00",
"hemoglobin_g_dL": 12.2,
"wbc_k_uL": 5.9,
"platelets_k_uL": 371,
"creatinine_mg_dL": 0.79,
"alt_U_L": 75
},
{
"date": "2026-03-23T00:00:00",
"hemoglobin_g_dL": 12.5,
"wbc_k_uL": 5.4,
"platelets_k_uL": 136,
"creatinine_mg_dL": 1.37,
... |
ANODE_SYNTH_2025_9865 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 14.3,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 23
} | {
"age": 74,
"sex": "female",
"bmi": 32.6,
"smoking_pack_years": 29,
"ecog_performance_status": 0,
"comorbidities": [
"hypertension",
"diabetes"
]
} | {
"primary_tumor_size_cm": 5,
"metastatic_sites": [
"liver"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2021-09-06T00:00:00",
"best_response": "Stable disease",
"radiologic_response": {
"first_ct_8wk_change_percent": -24,
"peak_response_20wk_change_percent": -63
},
"pfs_months": 29.37
},
"second_line_ther... | {
"overall_survival_months": 59.7,
"censored": false
} | [
{
"date": "2021-07-10T00:00:00",
"hemoglobin_g_dL": 15.3,
"wbc_k_uL": 10.3,
"platelets_k_uL": 356,
"creatinine_mg_dL": 1.27,
"alt_U_L": 42
},
{
"date": "2022-03-05T00:00:00",
"hemoglobin_g_dL": 13.8,
"wbc_k_uL": 5.4,
"platelets_k_uL": 253,
"creatinine_mg_dL": 1.1,
... |
ANODE_SYNTH_2025_9866 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 15.3,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 5
} | {
"age": 52,
"sex": "female",
"bmi": 24,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": [
"COPD"
]
} | {
"primary_tumor_size_cm": 6.2,
"metastatic_sites": [
"pleura",
"bone"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2020-02-22T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -45,
"peak_response_20wk_change_percent": -35
},
"pfs_months": 14.32
},
"second_line... | {
"overall_survival_months": 29.8,
"censored": false
} | [
{
"date": "2020-01-17T00:00:00",
"hemoglobin_g_dL": 14,
"wbc_k_uL": 6.5,
"platelets_k_uL": 255,
"creatinine_mg_dL": 0.88,
"alt_U_L": 16
},
{
"date": "2020-08-20T00:00:00",
"hemoglobin_g_dL": 10,
"wbc_k_uL": 6.5,
"platelets_k_uL": 188,
"creatinine_mg_dL": 0.95,
"al... |
ANODE_SYNTH_2025_9867 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 8.3,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 29
} | {
"age": 70,
"sex": "female",
"bmi": 27.9,
"smoking_pack_years": 65,
"ecog_performance_status": 2,
"comorbidities": []
} | {
"primary_tumor_size_cm": 3.1,
"metastatic_sites": [
"contralateral lung",
"brain",
"pleura"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2020-08-08T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -48,
"peak_response_20wk_change_percent": -58
},
"pfs_months": 36.9
},
"second_line_the... | {
"overall_survival_months": 62.6,
"censored": false
} | [
{
"date": "2020-06-19T00:00:00",
"hemoglobin_g_dL": 11.8,
"wbc_k_uL": 8.9,
"platelets_k_uL": 264,
"creatinine_mg_dL": 1.06,
"alt_U_L": 67
},
{
"date": "2021-02-04T00:00:00",
"hemoglobin_g_dL": 10.3,
"wbc_k_uL": 8.3,
"platelets_k_uL": 361,
"creatinine_mg_dL": 0.97,
... |
ANODE_SYNTH_2025_9868 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "EGFR L858R",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 14.1,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 33
} | {
"age": 66,
"sex": "female",
"bmi": 20.6,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 7.2,
"metastatic_sites": [
"liver",
"brain",
"bone"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2021-08-07T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -13,
"peak_response_20wk_change_percent": -32
},
"pfs_months": 25.23
},
"second_line... | {
"overall_survival_months": 33.9,
"censored": false
} | [
{
"date": "2021-06-26T00:00:00",
"hemoglobin_g_dL": 12.2,
"wbc_k_uL": 6,
"platelets_k_uL": 222,
"creatinine_mg_dL": 1.18,
"alt_U_L": 26
},
{
"date": "2022-02-03T00:00:00",
"hemoglobin_g_dL": 12.4,
"wbc_k_uL": 4.7,
"platelets_k_uL": 301,
"creatinine_mg_dL": 1.51,
"... |
ANODE_SYNTH_2025_9869 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 16,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 34
} | {
"age": 86,
"sex": "male",
"bmi": 33.8,
"smoking_pack_years": 34,
"ecog_performance_status": 1,
"comorbidities": [
"hypertension",
"hyperlipidemia"
]
} | {
"primary_tumor_size_cm": 3.4,
"metastatic_sites": [
"contralateral lung"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2024-02-23T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -59,
"peak_response_20wk_change_percent": -30
},
"pfs_months": 9.17
},
"second_line_t... | {
"overall_survival_months": 15.5,
"censored": false
} | [
{
"date": "2023-12-23T00:00:00",
"hemoglobin_g_dL": 13.8,
"wbc_k_uL": 5.5,
"platelets_k_uL": 408,
"creatinine_mg_dL": 0.61,
"alt_U_L": 68
},
{
"date": "2024-08-21T00:00:00",
"hemoglobin_g_dL": 13.1,
"wbc_k_uL": 8.7,
"platelets_k_uL": 322,
"creatinine_mg_dL": 1.07,
... |
ANODE_SYNTH_2025_9870 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 5.3,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 32
} | {
"age": 58,
"sex": "female",
"bmi": 35.1,
"smoking_pack_years": 31,
"ecog_performance_status": 1,
"comorbidities": [
"COPD",
"hyperlipidemia"
]
} | {
"primary_tumor_size_cm": 6.1,
"metastatic_sites": [
"brain",
"bone"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2022-01-05T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -29,
"peak_response_20wk_change_percent": -59
},
"pfs_months": 28.68
},
"second_line_th... | {
"overall_survival_months": 62.5,
"censored": true
} | [
{
"date": "2021-11-23T00:00:00",
"hemoglobin_g_dL": 13.4,
"wbc_k_uL": 5.5,
"platelets_k_uL": 376,
"creatinine_mg_dL": 1.14,
"alt_U_L": 41
},
{
"date": "2022-07-04T00:00:00",
"hemoglobin_g_dL": 10.3,
"wbc_k_uL": 7.1,
"platelets_k_uL": 230,
"creatinine_mg_dL": 1.21,
... |
ANODE_SYNTH_2025_9871 | Non-small cell lung cancer | Squamous cell carcinoma | IVB | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 17.9,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 30
} | {
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"sex": "female",
"bmi": 35.6,
"smoking_pack_years": 36,
"ecog_performance_status": 1,
"comorbidities": [
"COPD",
"hyperlipidemia"
]
} | {
"primary_tumor_size_cm": 7.1,
"metastatic_sites": [
"liver"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2022-07-07T00:00:00",
"best_response": "Stable disease",
"radiologic_response": {
"first_ct_8wk_change_percent": -10,
"peak_response_20wk_change_percent": -48
},
"pfs_months": 19.81
},... | {
"overall_survival_months": 32.2,
"censored": false
} | [
{
"date": "2022-05-24T00:00:00",
"hemoglobin_g_dL": 15.3,
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"platelets_k_uL": 263,
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"alt_U_L": 25
},
{
"date": "2023-01-03T00:00:00",
"hemoglobin_g_dL": 12.1,
"wbc_k_uL": 7.1,
"platelets_k_uL": 175,
"creatinine_mg_dL": 1.5,
... |
ANODE_SYNTH_2025_9872 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR L858R",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 14.8,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 33
} | {
"age": 52,
"sex": "female",
"bmi": 22.3,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 6.5,
"metastatic_sites": [
"liver",
"bone",
"brain"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2022-02-10T00:00:00",
"best_response": "Partial response",
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"peak_response_20wk_change_percent": -45
},
"pfs_months": 14.82
},
"second_line... | {
"overall_survival_months": 26,
"censored": false
} | [
{
"date": "2021-12-27T00:00:00",
"hemoglobin_g_dL": 15.3,
"wbc_k_uL": 4.8,
"platelets_k_uL": 209,
"creatinine_mg_dL": 1.27,
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},
{
"date": "2022-08-09T00:00:00",
"hemoglobin_g_dL": 10.8,
"wbc_k_uL": 4.1,
"platelets_k_uL": 218,
"creatinine_mg_dL": 1.3,
... |
ANODE_SYNTH_2025_9873 | Non-small cell lung cancer | Squamous cell carcinoma | IVB | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 7.3,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 31
} | {
"age": 55,
"sex": "female",
"bmi": 34.7,
"smoking_pack_years": 41,
"ecog_performance_status": 1,
"comorbidities": [
"hyperlipidemia"
]
} | {
"primary_tumor_size_cm": 7.5,
"metastatic_sites": [
"contralateral lung",
"brain"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2025-09-21T00:00:00",
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"radiologic_response": {
"first_ct_8wk_change_percent": -45,
"peak_response_20wk_change_percent": -39
},
"pfs_months": 25.36
... | {
"overall_survival_months": 39.8,
"censored": false
} | [
{
"date": "2025-08-13T00:00:00",
"hemoglobin_g_dL": 12.8,
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"platelets_k_uL": 238,
"creatinine_mg_dL": 0.64,
"alt_U_L": 14
},
{
"date": "2026-03-20T00:00:00",
"hemoglobin_g_dL": 12.9,
"wbc_k_uL": 6.1,
"platelets_k_uL": 313,
"creatinine_mg_dL": 1.54,
... |
ANODE_SYNTH_2025_9874 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 9.3,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 24
} | {
"age": 54,
"sex": "male",
"bmi": 26.3,
"smoking_pack_years": 67,
"ecog_performance_status": 1,
"comorbidities": [
"hyperlipidemia"
]
} | {
"primary_tumor_size_cm": 8.2,
"metastatic_sites": [
"liver",
"brain",
"bone"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2022-12-13T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -25,
"peak_response_20wk_change_percent": -42
},
"pfs_months": 2.96
},
"second_line_t... | {
"overall_survival_months": 6.9,
"censored": false
} | [
{
"date": "2022-11-22T00:00:00",
"hemoglobin_g_dL": 12.9,
"wbc_k_uL": 9.1,
"platelets_k_uL": 251,
"creatinine_mg_dL": 0.72,
"alt_U_L": 77
},
{
"date": "2023-06-11T00:00:00",
"hemoglobin_g_dL": 12.4,
"wbc_k_uL": 6.3,
"platelets_k_uL": 270,
"creatinine_mg_dL": 1.4,
... |
ANODE_SYNTH_2025_9875 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 4.1,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 27
} | {
"age": 72,
"sex": "female",
"bmi": 36,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 7.6,
"metastatic_sites": [
"liver",
"contralateral lung",
"brain"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2025-08-14T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -16,
"peak_response_20wk_change_percent": -53
},
"pfs_months": 21.49
},
"second_line... | {
"overall_survival_months": 30.6,
"censored": false
} | [
{
"date": "2025-06-11T00:00:00",
"hemoglobin_g_dL": 14.3,
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"platelets_k_uL": 273,
"creatinine_mg_dL": 1.04,
"alt_U_L": 79
},
{
"date": "2026-02-10T00:00:00",
"hemoglobin_g_dL": 13.3,
"wbc_k_uL": 8.5,
"platelets_k_uL": 285,
"creatinine_mg_dL": 1.39,
... |
ANODE_SYNTH_2025_9876 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 17.9,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 3
} | {
"age": 77,
"sex": "female",
"bmi": 22.3,
"smoking_pack_years": 0,
"ecog_performance_status": 0,
"comorbidities": [
"hypertension",
"hyperlipidemia"
]
} | {
"primary_tumor_size_cm": 3.9,
"metastatic_sites": [
"pleura",
"bone",
"brain"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2021-04-19T00:00:00",
"best_response": "Stable disease",
"radiologic_response": {
"first_ct_8wk_change_percent": -59,
"peak_response_20wk_change_percent": -71
},
"pfs_months": 29.54
},
"second_line_t... | {
"overall_survival_months": 50.6,
"censored": false
} | [
{
"date": "2021-03-09T00:00:00",
"hemoglobin_g_dL": 14.5,
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"platelets_k_uL": 191,
"creatinine_mg_dL": 0.97,
"alt_U_L": 18
},
{
"date": "2021-10-16T00:00:00",
"hemoglobin_g_dL": 12.8,
"wbc_k_uL": 4.4,
"platelets_k_uL": 203,
"creatinine_mg_dL": 1.4,
... |
ANODE_SYNTH_2025_9877 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR L858R",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 10.2,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 21
} | {
"age": 88,
"sex": "female",
"bmi": 26.1,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": [
"hypertension",
"COPD"
]
} | {
"primary_tumor_size_cm": 7.1,
"metastatic_sites": [
"liver",
"brain",
"pleura"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2020-05-02T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -22,
"peak_response_20wk_change_percent": -42
},
"pfs_months": 32.79
},
"second_line... | {
"overall_survival_months": 39.6,
"censored": true
} | [
{
"date": "2020-03-18T00:00:00",
"hemoglobin_g_dL": 14.9,
"wbc_k_uL": 6,
"platelets_k_uL": 151,
"creatinine_mg_dL": 0.76,
"alt_U_L": 34
},
{
"date": "2020-10-29T00:00:00",
"hemoglobin_g_dL": 10.3,
"wbc_k_uL": 8.4,
"platelets_k_uL": 249,
"creatinine_mg_dL": 1.44,
"... |
ANODE_SYNTH_2025_9878 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 5.5,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 5
} | {
"age": 60,
"sex": "female",
"bmi": 20.8,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": []
} | {
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"metastatic_sites": [
"pleura"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2023-03-14T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -51,
"peak_response_20wk_change_percent": -69
},
"pfs_months": 15.93
},
"second_line... | {
"overall_survival_months": 33.3,
"censored": true
} | [
{
"date": "2023-01-25T00:00:00",
"hemoglobin_g_dL": 13.1,
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"platelets_k_uL": 379,
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"alt_U_L": 40
},
{
"date": "2023-09-10T00:00:00",
"hemoglobin_g_dL": 12,
"wbc_k_uL": 5,
"platelets_k_uL": 280,
"creatinine_mg_dL": 1.41,
"al... |
ANODE_SYNTH_2025_9879 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 12.1,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 1
} | {
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"sex": "female",
"bmi": 24.5,
"smoking_pack_years": 54,
"ecog_performance_status": 2,
"comorbidities": [
"diabetes",
"COPD"
]
} | {
"primary_tumor_size_cm": 7.8,
"metastatic_sites": [
"liver"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2020-11-28T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -53,
"peak_response_20wk_change_percent": -55
},
"pfs_months": 7.98
},
"second_line_t... | {
"overall_survival_months": 21.3,
"censored": false
} | [
{
"date": "2020-10-26T00:00:00",
"hemoglobin_g_dL": 12.3,
"wbc_k_uL": 8.4,
"platelets_k_uL": 398,
"creatinine_mg_dL": 1.14,
"alt_U_L": 20
},
{
"date": "2021-05-27T00:00:00",
"hemoglobin_g_dL": 14,
"wbc_k_uL": 5.8,
"platelets_k_uL": 253,
"creatinine_mg_dL": 0.87,
"... |
ANODE_SYNTH_2025_9880 | Non-small cell lung cancer | Squamous cell carcinoma | IV | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 2.1,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 28
} | {
"age": 63,
"sex": "female",
"bmi": 20.2,
"smoking_pack_years": 69,
"ecog_performance_status": 1,
"comorbidities": [
"diabetes"
]
} | {
"primary_tumor_size_cm": 5.2,
"metastatic_sites": [
"liver",
"bone",
"brain"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2020-10-15T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -37,
"peak_response_20wk_change_percent": -30
},
"pfs_months": 21.88
... | {
"overall_survival_months": 37.6,
"censored": false
} | [
{
"date": "2020-08-19T00:00:00",
"hemoglobin_g_dL": 12.4,
"wbc_k_uL": 6.9,
"platelets_k_uL": 271,
"creatinine_mg_dL": 0.7,
"alt_U_L": 45
},
{
"date": "2021-04-13T00:00:00",
"hemoglobin_g_dL": 10.7,
"wbc_k_uL": 8.9,
"platelets_k_uL": 141,
"creatinine_mg_dL": 0.72,
... |
ANODE_SYNTH_2025_9881 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "EGFR L858R",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 9.2,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 16
} | {
"age": 75,
"sex": "female",
"bmi": 37.8,
"smoking_pack_years": 0,
"ecog_performance_status": 0,
"comorbidities": []
} | {
"primary_tumor_size_cm": 7.4,
"metastatic_sites": [
"pleura",
"brain"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2025-05-24T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -59,
"peak_response_20wk_change_percent": -44
},
"pfs_months": 24.9
},
"second_line_... | {
"overall_survival_months": 39.4,
"censored": false
} | [
{
"date": "2025-03-21T00:00:00",
"hemoglobin_g_dL": 15,
"wbc_k_uL": 6,
"platelets_k_uL": 421,
"creatinine_mg_dL": 0.65,
"alt_U_L": 41
},
{
"date": "2025-11-20T00:00:00",
"hemoglobin_g_dL": 13,
"wbc_k_uL": 6.6,
"platelets_k_uL": 244,
"creatinine_mg_dL": 1.39,
"alt_... |
ANODE_SYNTH_2025_9882 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR L858R",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 16,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 6
} | {
"age": 62,
"sex": "female",
"bmi": 22,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 4.8,
"metastatic_sites": [
"contralateral lung",
"bone",
"brain"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2021-07-24T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -41,
"peak_response_20wk_change_percent": -67
},
"pfs_months": 23.39
},
"second_line... | {
"overall_survival_months": 40.6,
"censored": true
} | [
{
"date": "2021-06-03T00:00:00",
"hemoglobin_g_dL": 12.9,
"wbc_k_uL": 6.3,
"platelets_k_uL": 239,
"creatinine_mg_dL": 0.68,
"alt_U_L": 79
},
{
"date": "2022-01-20T00:00:00",
"hemoglobin_g_dL": 11.5,
"wbc_k_uL": 5.7,
"platelets_k_uL": 172,
"creatinine_mg_dL": 1.37,
... |
ANODE_SYNTH_2025_9883 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR L858R",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 16.2,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 28
} | {
"age": 58,
"sex": "female",
"bmi": 27.8,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": [
"diabetes"
]
} | {
"primary_tumor_size_cm": 3.5,
"metastatic_sites": [
"pleura",
"liver",
"bone"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2022-04-25T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -13,
"peak_response_20wk_change_percent": -49
},
"pfs_months": 26.94
},
"second_line... | {
"overall_survival_months": 41.8,
"censored": true
} | [
{
"date": "2022-03-05T00:00:00",
"hemoglobin_g_dL": 12.9,
"wbc_k_uL": 5.4,
"platelets_k_uL": 420,
"creatinine_mg_dL": 0.9,
"alt_U_L": 62
},
{
"date": "2022-10-22T00:00:00",
"hemoglobin_g_dL": 10.6,
"wbc_k_uL": 7,
"platelets_k_uL": 337,
"creatinine_mg_dL": 1.08,
"a... |
ANODE_SYNTH_2025_9884 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 5,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 18
} | {
"age": 58,
"sex": "female",
"bmi": 18.7,
"smoking_pack_years": 71,
"ecog_performance_status": 1,
"comorbidities": [
"diabetes"
]
} | {
"primary_tumor_size_cm": 6.3,
"metastatic_sites": [
"contralateral lung",
"liver",
"pleura"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2023-06-13T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -39,
"peak_response_20wk_change_percent": -50
},
"pfs_months": 37.39
},
"second_line_th... | {
"overall_survival_months": 59.2,
"censored": true
} | [
{
"date": "2023-04-28T00:00:00",
"hemoglobin_g_dL": 15.2,
"wbc_k_uL": 7.1,
"platelets_k_uL": 381,
"creatinine_mg_dL": 0.67,
"alt_U_L": 50
},
{
"date": "2023-12-10T00:00:00",
"hemoglobin_g_dL": 10,
"wbc_k_uL": 4.7,
"platelets_k_uL": 285,
"creatinine_mg_dL": 0.93,
"... |
ANODE_SYNTH_2025_9885 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 13.2,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 25
} | {
"age": 69,
"sex": "male",
"bmi": 27,
"smoking_pack_years": 74,
"ecog_performance_status": 0,
"comorbidities": [
"hyperlipidemia",
"COPD"
]
} | {
"primary_tumor_size_cm": 7.9,
"metastatic_sites": [
"brain",
"liver"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2022-11-28T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -46,
"peak_response_20wk_change_percent": -61
},
"pfs_months": 38.21
},
"second_line_th... | {
"overall_survival_months": 63.2,
"censored": true
} | [
{
"date": "2022-10-05T00:00:00",
"hemoglobin_g_dL": 14.6,
"wbc_k_uL": 8.8,
"platelets_k_uL": 320,
"creatinine_mg_dL": 1.05,
"alt_U_L": 68
},
{
"date": "2023-05-27T00:00:00",
"hemoglobin_g_dL": 13.9,
"wbc_k_uL": 8.6,
"platelets_k_uL": 270,
"creatinine_mg_dL": 1.39,
... |
ANODE_SYNTH_2025_9886 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR L858R",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 7.3,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 30
} | {
"age": 54,
"sex": "female",
"bmi": 22.7,
"smoking_pack_years": 0,
"ecog_performance_status": 0,
"comorbidities": []
} | {
"primary_tumor_size_cm": 6,
"metastatic_sites": [
"bone",
"brain"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2024-05-19T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -46,
"peak_response_20wk_change_percent": -53
},
"pfs_months": 13.44
},
"second_line... | {
"overall_survival_months": 31.4,
"censored": false
} | [
{
"date": "2024-03-24T00:00:00",
"hemoglobin_g_dL": 12.3,
"wbc_k_uL": 6.1,
"platelets_k_uL": 198,
"creatinine_mg_dL": 0.86,
"alt_U_L": 24
},
{
"date": "2024-11-15T00:00:00",
"hemoglobin_g_dL": 12.1,
"wbc_k_uL": 4.7,
"platelets_k_uL": 146,
"creatinine_mg_dL": 1.34,
... |
ANODE_SYNTH_2025_9887 | Non-small cell lung cancer | Squamous cell carcinoma | IVB | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 15.7,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 35
} | {
"age": 48,
"sex": "male",
"bmi": 28.2,
"smoking_pack_years": 77,
"ecog_performance_status": 0,
"comorbidities": [
"hypertension"
]
} | {
"primary_tumor_size_cm": 6.9,
"metastatic_sites": [
"contralateral lung",
"liver",
"bone"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2024-01-18T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -25,
"peak_response_20wk_change_percent": -55
},
"pfs_months": 21.13
... | {
"overall_survival_months": 43.6,
"censored": false
} | [
{
"date": "2023-12-02T00:00:00",
"hemoglobin_g_dL": 12.6,
"wbc_k_uL": 8.9,
"platelets_k_uL": 269,
"creatinine_mg_dL": 0.87,
"alt_U_L": 18
},
{
"date": "2024-07-16T00:00:00",
"hemoglobin_g_dL": 13.1,
"wbc_k_uL": 8.8,
"platelets_k_uL": 213,
"creatinine_mg_dL": 0.71,
... |
ANODE_SYNTH_2025_9888 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 10.4,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 12
} | {
"age": 65,
"sex": "female",
"bmi": 33.5,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": [
"COPD"
]
} | {
"primary_tumor_size_cm": 8.2,
"metastatic_sites": [
"contralateral lung",
"brain"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2024-02-28T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -29,
"peak_response_20wk_change_percent": -74
},
"pfs_months": 26.38
},
"second_line... | {
"overall_survival_months": 32.1,
"censored": true
} | [
{
"date": "2024-01-02T00:00:00",
"hemoglobin_g_dL": 11.8,
"wbc_k_uL": 6.1,
"platelets_k_uL": 449,
"creatinine_mg_dL": 0.83,
"alt_U_L": 56
},
{
"date": "2024-08-26T00:00:00",
"hemoglobin_g_dL": 11.7,
"wbc_k_uL": 4.8,
"platelets_k_uL": 139,
"creatinine_mg_dL": 1.39,
... |
ANODE_SYNTH_2025_9889 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 16.6,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 27
} | {
"age": 76,
"sex": "female",
"bmi": 24.4,
"smoking_pack_years": 34,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 7.3,
"metastatic_sites": [
"contralateral lung",
"pleura"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2022-12-20T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -23,
"peak_response_20wk_change_percent": -66
},
"pfs_months": 23.29
},
"second_line_... | {
"overall_survival_months": 32,
"censored": false
} | [
{
"date": "2022-10-13T00:00:00",
"hemoglobin_g_dL": 15.5,
"wbc_k_uL": 7,
"platelets_k_uL": 270,
"creatinine_mg_dL": 1.16,
"alt_U_L": 75
},
{
"date": "2023-06-18T00:00:00",
"hemoglobin_g_dL": 10.3,
"wbc_k_uL": 7.2,
"platelets_k_uL": 206,
"creatinine_mg_dL": 0.8,
"a... |
ANODE_SYNTH_2025_9890 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 13.9,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 7
} | {
"age": 52,
"sex": "female",
"bmi": 32.1,
"smoking_pack_years": 31,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 6.8,
"metastatic_sites": [
"contralateral lung"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2021-04-05T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -37,
"peak_response_20wk_change_percent": -72
},
"pfs_months": 4.14
},
"second_line_t... | {
"overall_survival_months": 15.8,
"censored": true
} | [
{
"date": "2021-03-20T00:00:00",
"hemoglobin_g_dL": 12.8,
"wbc_k_uL": 5.7,
"platelets_k_uL": 411,
"creatinine_mg_dL": 1.12,
"alt_U_L": 49
},
{
"date": "2021-10-02T00:00:00",
"hemoglobin_g_dL": 10.9,
"wbc_k_uL": 4.5,
"platelets_k_uL": 372,
"creatinine_mg_dL": 0.86,
... |
ANODE_SYNTH_2025_9891 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 3.3,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 31
} | {
"age": 84,
"sex": "female",
"bmi": 29.9,
"smoking_pack_years": 0,
"ecog_performance_status": 0,
"comorbidities": [
"COPD"
]
} | {
"primary_tumor_size_cm": 7.9,
"metastatic_sites": [
"contralateral lung"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2024-04-11T00:00:00",
"best_response": "Stable disease",
"radiologic_response": {
"first_ct_8wk_change_percent": -53,
"peak_response_20wk_change_percent": -43
},
"pfs_months": 22.7
},
"second_line_th... | {
"overall_survival_months": 40.6,
"censored": true
} | [
{
"date": "2024-03-24T00:00:00",
"hemoglobin_g_dL": 14.4,
"wbc_k_uL": 4.8,
"platelets_k_uL": 365,
"creatinine_mg_dL": 1.2,
"alt_U_L": 73
},
{
"date": "2024-10-08T00:00:00",
"hemoglobin_g_dL": 11.1,
"wbc_k_uL": 7.2,
"platelets_k_uL": 203,
"creatinine_mg_dL": 0.8,
"... |
ANODE_SYNTH_2025_9892 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "EGFR L858R",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 11.8,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 20
} | {
"age": 84,
"sex": "female",
"bmi": 36.9,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": [
"hyperlipidemia"
]
} | {
"primary_tumor_size_cm": 5.1,
"metastatic_sites": [
"contralateral lung"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2024-07-04T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -46,
"peak_response_20wk_change_percent": -34
},
"pfs_months": 12.55
},
"second_line... | {
"overall_survival_months": 26.9,
"censored": false
} | [
{
"date": "2024-05-05T00:00:00",
"hemoglobin_g_dL": 12.6,
"wbc_k_uL": 4.6,
"platelets_k_uL": 229,
"creatinine_mg_dL": 0.73,
"alt_U_L": 59
},
{
"date": "2024-12-31T00:00:00",
"hemoglobin_g_dL": 12,
"wbc_k_uL": 6.6,
"platelets_k_uL": 333,
"creatinine_mg_dL": 1.55,
"... |
ANODE_SYNTH_2025_9893 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR L858R",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 4.5,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 27
} | {
"age": 77,
"sex": "female",
"bmi": 27.2,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 6.1,
"metastatic_sites": [
"liver",
"bone"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2024-10-11T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -50,
"peak_response_20wk_change_percent": -74
},
"pfs_months": 20.34
},
"second_line... | {
"overall_survival_months": 28.6,
"censored": true
} | [
{
"date": "2024-09-14T00:00:00",
"hemoglobin_g_dL": 15.4,
"wbc_k_uL": 9.1,
"platelets_k_uL": 292,
"creatinine_mg_dL": 0.7,
"alt_U_L": 33
},
{
"date": "2025-04-09T00:00:00",
"hemoglobin_g_dL": 12,
"wbc_k_uL": 8,
"platelets_k_uL": 267,
"creatinine_mg_dL": 1.04,
"alt... |
ANODE_SYNTH_2025_9894 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 15.6,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 18
} | {
"age": 65,
"sex": "female",
"bmi": 21.3,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 8,
"metastatic_sites": [
"bone",
"contralateral lung"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2024-11-18T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -15,
"peak_response_20wk_change_percent": -55
},
"pfs_months": 28.32
},
"second_line... | {
"overall_survival_months": 37.4,
"censored": false
} | [
{
"date": "2024-09-22T00:00:00",
"hemoglobin_g_dL": 14.7,
"wbc_k_uL": 5,
"platelets_k_uL": 400,
"creatinine_mg_dL": 1.2,
"alt_U_L": 21
},
{
"date": "2025-05-17T00:00:00",
"hemoglobin_g_dL": 12.7,
"wbc_k_uL": 5.7,
"platelets_k_uL": 152,
"creatinine_mg_dL": 1.41,
"a... |
ANODE_SYNTH_2025_9895 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 16.4,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 21
} | {
"age": 56,
"sex": "male",
"bmi": 20.2,
"smoking_pack_years": 38,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 7.7,
"metastatic_sites": [
"liver",
"contralateral lung"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2021-09-07T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -59,
"peak_response_20wk_change_percent": -33
},
"pfs_months": 8.38
},
"second_line_t... | {
"overall_survival_months": 20.3,
"censored": false
} | [
{
"date": "2021-08-23T00:00:00",
"hemoglobin_g_dL": 14.5,
"wbc_k_uL": 5,
"platelets_k_uL": 389,
"creatinine_mg_dL": 0.68,
"alt_U_L": 31
},
{
"date": "2022-03-06T00:00:00",
"hemoglobin_g_dL": 10,
"wbc_k_uL": 5.6,
"platelets_k_uL": 152,
"creatinine_mg_dL": 0.87,
"al... |
ANODE_SYNTH_2025_9896 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 16.6,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 4
} | {
"age": 75,
"sex": "male",
"bmi": 30.6,
"smoking_pack_years": 17,
"ecog_performance_status": 1,
"comorbidities": [
"COPD"
]
} | {
"primary_tumor_size_cm": 8.2,
"metastatic_sites": [
"liver"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2022-04-01T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -25,
"peak_response_20wk_change_percent": -75
},
"pfs_months": 35.91
},
"second_line_th... | {
"overall_survival_months": 60.8,
"censored": false
} | [
{
"date": "2022-03-09T00:00:00",
"hemoglobin_g_dL": 13.9,
"wbc_k_uL": 9.7,
"platelets_k_uL": 376,
"creatinine_mg_dL": 0.66,
"alt_U_L": 61
},
{
"date": "2022-09-28T00:00:00",
"hemoglobin_g_dL": 12.3,
"wbc_k_uL": 7.3,
"platelets_k_uL": 287,
"creatinine_mg_dL": 1.16,
... |
ANODE_SYNTH_2025_9897 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 9.3,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 20
} | {
"age": 68,
"sex": "male",
"bmi": 30.5,
"smoking_pack_years": 44,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 5.5,
"metastatic_sites": [
"bone"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2020-11-10T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -54,
"peak_response_20wk_change_percent": -38
},
"pfs_months": 7.36
},
"second_line_t... | {
"overall_survival_months": 23.8,
"censored": true
} | [
{
"date": "2020-09-25T00:00:00",
"hemoglobin_g_dL": 12.9,
"wbc_k_uL": 6.5,
"platelets_k_uL": 411,
"creatinine_mg_dL": 1.3,
"alt_U_L": 12
},
{
"date": "2021-05-09T00:00:00",
"hemoglobin_g_dL": 14,
"wbc_k_uL": 5.6,
"platelets_k_uL": 157,
"creatinine_mg_dL": 1.55,
"a... |
ANODE_SYNTH_2025_9898 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 5.1,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 3
} | {
"age": 54,
"sex": "female",
"bmi": 21.5,
"smoking_pack_years": 35,
"ecog_performance_status": 1,
"comorbidities": [
"diabetes",
"hypertension"
]
} | {
"primary_tumor_size_cm": 6.4,
"metastatic_sites": [
"bone"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2022-02-21T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -26,
"peak_response_20wk_change_percent": -72
},
"pfs_months": 41.17
},
"second_line_th... | {
"overall_survival_months": 60.2,
"censored": true
} | [
{
"date": "2022-01-26T00:00:00",
"hemoglobin_g_dL": 14.9,
"wbc_k_uL": 9.2,
"platelets_k_uL": 354,
"creatinine_mg_dL": 0.63,
"alt_U_L": 64
},
{
"date": "2022-08-20T00:00:00",
"hemoglobin_g_dL": 11.4,
"wbc_k_uL": 7.9,
"platelets_k_uL": 351,
"creatinine_mg_dL": 1.58,
... |
ANODE_SYNTH_2025_9899 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR L858R",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 15.5,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 22
} | {
"age": 82,
"sex": "female",
"bmi": 36.4,
"smoking_pack_years": 0,
"ecog_performance_status": 0,
"comorbidities": [
"diabetes",
"hyperlipidemia"
]
} | {
"primary_tumor_size_cm": 8.5,
"metastatic_sites": [
"pleura",
"brain",
"liver"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2025-05-14T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -53,
"peak_response_20wk_change_percent": -59
},
"pfs_months": 21.65
},
"second_line... | {
"overall_survival_months": 36.5,
"censored": true
} | [
{
"date": "2025-04-11T00:00:00",
"hemoglobin_g_dL": 14.6,
"wbc_k_uL": 10.1,
"platelets_k_uL": 338,
"creatinine_mg_dL": 0.94,
"alt_U_L": 63
},
{
"date": "2025-11-10T00:00:00",
"hemoglobin_g_dL": 12,
"wbc_k_uL": 4.6,
"platelets_k_uL": 335,
"creatinine_mg_dL": 0.9,
"... |
ANODE_SYNTH_2025_9900 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 6.9,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 27
} | {
"age": 57,
"sex": "male",
"bmi": 26.9,
"smoking_pack_years": 12,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 4.9,
"metastatic_sites": [
"contralateral lung"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2022-08-29T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -27,
"peak_response_20wk_change_percent": -41
},
"pfs_months": 6.8
},
"second_line_th... | {
"overall_survival_months": 10.7,
"censored": false
} | [
{
"date": "2022-08-07T00:00:00",
"hemoglobin_g_dL": 12.8,
"wbc_k_uL": 9.8,
"platelets_k_uL": 283,
"creatinine_mg_dL": 0.8,
"alt_U_L": 29
},
{
"date": "2023-02-25T00:00:00",
"hemoglobin_g_dL": 12,
"wbc_k_uL": 8.9,
"platelets_k_uL": 152,
"creatinine_mg_dL": 1.04,
"a... |
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