patient_id stringlengths 20 22 | cancer_type stringclasses 1
value | histology stringclasses 2
values | stage_at_diagnosis stringclasses 2
values | molecular_profile dict | baseline_clinical dict | disease_burden_at_dx dict | treatment_course dict | survival_outcomes dict | longitudinal_labs listlengths 3 3 |
|---|---|---|---|---|---|---|---|---|---|
ANODE_SYNTH_2025_9901 | Non-small cell lung cancer | Squamous cell carcinoma | IV | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 17.1,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 16
} | {
"age": 50,
"sex": "female",
"bmi": 25.7,
"smoking_pack_years": 51,
"ecog_performance_status": 1,
"comorbidities": [
"diabetes",
"hypertension"
]
} | {
"primary_tumor_size_cm": 3.4,
"metastatic_sites": [
"liver",
"bone"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2021-12-01T00:00:00",
"best_response": "Stable disease",
"radiologic_response": {
"first_ct_8wk_change_percent": -16,
"peak_response_20wk_change_percent": -39
},
"pfs_months": 17.84
},... | {
"overall_survival_months": 34.1,
"censored": true
} | [
{
"date": "2021-11-09T00:00:00",
"hemoglobin_g_dL": 13.4,
"wbc_k_uL": 6.5,
"platelets_k_uL": 338,
"creatinine_mg_dL": 0.74,
"alt_U_L": 17
},
{
"date": "2022-05-30T00:00:00",
"hemoglobin_g_dL": 10.8,
"wbc_k_uL": 5.8,
"platelets_k_uL": 372,
"creatinine_mg_dL": 1.5,
... |
ANODE_SYNTH_2025_9902 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 4.1,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 2
} | {
"age": 52,
"sex": "female",
"bmi": 32.6,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": [
"hyperlipidemia",
"hypertension"
]
} | {
"primary_tumor_size_cm": 6.5,
"metastatic_sites": [
"brain",
"liver",
"pleura"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2020-12-19T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -52,
"peak_response_20wk_change_percent": -73
},
"pfs_months": 28.39
},
"second_line... | {
"overall_survival_months": 39.2,
"censored": false
} | [
{
"date": "2020-12-05T00:00:00",
"hemoglobin_g_dL": 11.7,
"wbc_k_uL": 6.4,
"platelets_k_uL": 429,
"creatinine_mg_dL": 1.11,
"alt_U_L": 77
},
{
"date": "2021-06-17T00:00:00",
"hemoglobin_g_dL": 12.6,
"wbc_k_uL": 6.9,
"platelets_k_uL": 221,
"creatinine_mg_dL": 1.51,
... |
ANODE_SYNTH_2025_9903 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 17.1,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 16
} | {
"age": 81,
"sex": "female",
"bmi": 21.8,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": [
"hypertension"
]
} | {
"primary_tumor_size_cm": 4.2,
"metastatic_sites": [
"brain"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2021-05-20T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -52,
"peak_response_20wk_change_percent": -68
},
"pfs_months": 19.98
},
"second_line... | {
"overall_survival_months": 36.9,
"censored": true
} | [
{
"date": "2021-04-04T00:00:00",
"hemoglobin_g_dL": 11.9,
"wbc_k_uL": 9.6,
"platelets_k_uL": 243,
"creatinine_mg_dL": 1.09,
"alt_U_L": 76
},
{
"date": "2021-11-16T00:00:00",
"hemoglobin_g_dL": 11.7,
"wbc_k_uL": 6,
"platelets_k_uL": 294,
"creatinine_mg_dL": 1.05,
"... |
ANODE_SYNTH_2025_9904 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 17.3,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 33
} | {
"age": 71,
"sex": "male",
"bmi": 28,
"smoking_pack_years": 32,
"ecog_performance_status": 0,
"comorbidities": [
"diabetes"
]
} | {
"primary_tumor_size_cm": 4.5,
"metastatic_sites": [
"bone",
"liver",
"pleura"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2021-05-16T00:00:00",
"best_response": "Stable disease",
"radiologic_response": {
"first_ct_8wk_change_percent": -26,
"peak_response_20wk_change_percent": -40
},
"pfs_months": 8.31
},
"second_line_the... | {
"overall_survival_months": 21.3,
"censored": false
} | [
{
"date": "2021-04-27T00:00:00",
"hemoglobin_g_dL": 13.6,
"wbc_k_uL": 8.3,
"platelets_k_uL": 419,
"creatinine_mg_dL": 0.76,
"alt_U_L": 41
},
{
"date": "2021-11-12T00:00:00",
"hemoglobin_g_dL": 11.7,
"wbc_k_uL": 6.1,
"platelets_k_uL": 151,
"creatinine_mg_dL": 1.45,
... |
ANODE_SYNTH_2025_9905 | Non-small cell lung cancer | Squamous cell carcinoma | IV | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 2.4,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 4
} | {
"age": 67,
"sex": "female",
"bmi": 23.5,
"smoking_pack_years": 44,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 6.2,
"metastatic_sites": [
"pleura",
"contralateral lung"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2022-05-13T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -52,
"peak_response_20wk_change_percent": -74
},
"pfs_months": 21.91
... | {
"overall_survival_months": 37.3,
"censored": false
} | [
{
"date": "2022-03-11T00:00:00",
"hemoglobin_g_dL": 14.2,
"wbc_k_uL": 4.5,
"platelets_k_uL": 418,
"creatinine_mg_dL": 1.19,
"alt_U_L": 57
},
{
"date": "2022-11-09T00:00:00",
"hemoglobin_g_dL": 12.5,
"wbc_k_uL": 5.4,
"platelets_k_uL": 240,
"creatinine_mg_dL": 1.39,
... |
ANODE_SYNTH_2025_9906 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 8.1,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 30
} | {
"age": 53,
"sex": "female",
"bmi": 32.6,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": [
"hypertension",
"COPD"
]
} | {
"primary_tumor_size_cm": 5.6,
"metastatic_sites": [
"bone"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2023-01-04T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -21,
"peak_response_20wk_change_percent": -64
},
"pfs_months": 17.61
},
"second_line... | {
"overall_survival_months": 30.7,
"censored": true
} | [
{
"date": "2022-11-12T00:00:00",
"hemoglobin_g_dL": 13.9,
"wbc_k_uL": 6.6,
"platelets_k_uL": 245,
"creatinine_mg_dL": 0.91,
"alt_U_L": 32
},
{
"date": "2023-07-03T00:00:00",
"hemoglobin_g_dL": 10.7,
"wbc_k_uL": 4.9,
"platelets_k_uL": 351,
"creatinine_mg_dL": 1.5,
... |
ANODE_SYNTH_2025_9907 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 8.8,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 22
} | {
"age": 57,
"sex": "female",
"bmi": 31.4,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": [
"diabetes",
"hyperlipidemia"
]
} | {
"primary_tumor_size_cm": 3.2,
"metastatic_sites": [
"brain",
"contralateral lung",
"bone"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2024-03-06T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -33,
"peak_response_20wk_change_percent": -41
},
"pfs_months": 28.52
},
"second_line... | {
"overall_survival_months": 42.2,
"censored": false
} | [
{
"date": "2024-01-04T00:00:00",
"hemoglobin_g_dL": 14.5,
"wbc_k_uL": 4.9,
"platelets_k_uL": 269,
"creatinine_mg_dL": 0.96,
"alt_U_L": 64
},
{
"date": "2024-09-02T00:00:00",
"hemoglobin_g_dL": 13.2,
"wbc_k_uL": 5.2,
"platelets_k_uL": 145,
"creatinine_mg_dL": 0.75,
... |
ANODE_SYNTH_2025_9908 | Non-small cell lung cancer | Squamous cell carcinoma | IV | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 5.8,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 22
} | {
"age": 63,
"sex": "female",
"bmi": 31.5,
"smoking_pack_years": 21,
"ecog_performance_status": 0,
"comorbidities": [
"hyperlipidemia"
]
} | {
"primary_tumor_size_cm": 3,
"metastatic_sites": [
"contralateral lung",
"brain",
"bone"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2024-10-05T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -54,
"peak_response_20wk_change_percent": -39
},
"pfs_months": 21.55
... | {
"overall_survival_months": 39.3,
"censored": false
} | [
{
"date": "2024-08-28T00:00:00",
"hemoglobin_g_dL": 13.3,
"wbc_k_uL": 10.3,
"platelets_k_uL": 159,
"creatinine_mg_dL": 1.27,
"alt_U_L": 43
},
{
"date": "2025-04-03T00:00:00",
"hemoglobin_g_dL": 13.6,
"wbc_k_uL": 6.9,
"platelets_k_uL": 235,
"creatinine_mg_dL": 0.94,
... |
ANODE_SYNTH_2025_9909 | Non-small cell lung cancer | Squamous cell carcinoma | IV | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 9.6,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 3
} | {
"age": 76,
"sex": "male",
"bmi": 28,
"smoking_pack_years": 30,
"ecog_performance_status": 0,
"comorbidities": [
"hyperlipidemia"
]
} | {
"primary_tumor_size_cm": 8.4,
"metastatic_sites": [
"brain",
"bone"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2024-04-02T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -49,
"peak_response_20wk_change_percent": -53
},
"pfs_months": 14.98
... | {
"overall_survival_months": 34.6,
"censored": false
} | [
{
"date": "2024-02-03T00:00:00",
"hemoglobin_g_dL": 14.2,
"wbc_k_uL": 5.7,
"platelets_k_uL": 166,
"creatinine_mg_dL": 1.2,
"alt_U_L": 57
},
{
"date": "2024-09-29T00:00:00",
"hemoglobin_g_dL": 11.6,
"wbc_k_uL": 4.1,
"platelets_k_uL": 329,
"creatinine_mg_dL": 0.94,
... |
ANODE_SYNTH_2025_9910 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 13.5,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 9
} | {
"age": 71,
"sex": "male",
"bmi": 21.3,
"smoking_pack_years": 14,
"ecog_performance_status": 1,
"comorbidities": [
"diabetes"
]
} | {
"primary_tumor_size_cm": 5.9,
"metastatic_sites": [
"liver",
"pleura"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2025-05-18T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -35,
"peak_response_20wk_change_percent": -41
},
"pfs_months": 14.19
},
"second_line_... | {
"overall_survival_months": 28.6,
"censored": false
} | [
{
"date": "2025-04-03T00:00:00",
"hemoglobin_g_dL": 13.2,
"wbc_k_uL": 9.7,
"platelets_k_uL": 363,
"creatinine_mg_dL": 0.79,
"alt_U_L": 52
},
{
"date": "2025-11-14T00:00:00",
"hemoglobin_g_dL": 10.3,
"wbc_k_uL": 5.8,
"platelets_k_uL": 335,
"creatinine_mg_dL": 1.1,
... |
ANODE_SYNTH_2025_9911 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 10.4,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 35
} | {
"age": 50,
"sex": "female",
"bmi": 35.6,
"smoking_pack_years": 0,
"ecog_performance_status": 0,
"comorbidities": [
"diabetes"
]
} | {
"primary_tumor_size_cm": 7.7,
"metastatic_sites": [
"contralateral lung",
"pleura",
"brain"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2021-03-05T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -24,
"peak_response_20wk_change_percent": -74
},
"pfs_months": 24.97
},
"second_line... | {
"overall_survival_months": 37.6,
"censored": false
} | [
{
"date": "2021-01-14T00:00:00",
"hemoglobin_g_dL": 11.8,
"wbc_k_uL": 8,
"platelets_k_uL": 171,
"creatinine_mg_dL": 0.92,
"alt_U_L": 63
},
{
"date": "2021-09-01T00:00:00",
"hemoglobin_g_dL": 11.4,
"wbc_k_uL": 4.4,
"platelets_k_uL": 315,
"creatinine_mg_dL": 1.19,
"... |
ANODE_SYNTH_2025_9912 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 4.6,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 13
} | {
"age": 59,
"sex": "male",
"bmi": 37.5,
"smoking_pack_years": 40,
"ecog_performance_status": 1,
"comorbidities": [
"diabetes",
"hypertension"
]
} | {
"primary_tumor_size_cm": 4.2,
"metastatic_sites": [
"contralateral lung",
"brain"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2025-04-26T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -46,
"peak_response_20wk_change_percent": -60
},
"pfs_months": 7.1
},
"second_line_th... | {
"overall_survival_months": 16.1,
"censored": false
} | [
{
"date": "2025-03-22T00:00:00",
"hemoglobin_g_dL": 13.8,
"wbc_k_uL": 5.4,
"platelets_k_uL": 157,
"creatinine_mg_dL": 1.14,
"alt_U_L": 19
},
{
"date": "2025-10-23T00:00:00",
"hemoglobin_g_dL": 12,
"wbc_k_uL": 4.4,
"platelets_k_uL": 228,
"creatinine_mg_dL": 0.96,
"... |
ANODE_SYNTH_2025_9913 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 14.4,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 27
} | {
"age": 49,
"sex": "female",
"bmi": 33.2,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 6.2,
"metastatic_sites": [
"bone",
"liver",
"brain"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2025-01-23T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -51,
"peak_response_20wk_change_percent": -46
},
"pfs_months": 23.26
},
"second_line... | {
"overall_survival_months": 35.8,
"censored": false
} | [
{
"date": "2024-12-23T00:00:00",
"hemoglobin_g_dL": 11.8,
"wbc_k_uL": 8,
"platelets_k_uL": 387,
"creatinine_mg_dL": 1.23,
"alt_U_L": 44
},
{
"date": "2025-07-22T00:00:00",
"hemoglobin_g_dL": 13.4,
"wbc_k_uL": 8.5,
"platelets_k_uL": 249,
"creatinine_mg_dL": 0.72,
"... |
ANODE_SYNTH_2025_9914 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "EGFR L858R",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 13.3,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 8
} | {
"age": 54,
"sex": "female",
"bmi": 27,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": [
"COPD"
]
} | {
"primary_tumor_size_cm": 3.9,
"metastatic_sites": [
"pleura",
"brain",
"liver"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2024-12-06T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -45,
"peak_response_20wk_change_percent": -46
},
"pfs_months": 22.05
},
"second_line... | {
"overall_survival_months": 30.1,
"censored": true
} | [
{
"date": "2024-10-17T00:00:00",
"hemoglobin_g_dL": 11.8,
"wbc_k_uL": 7,
"platelets_k_uL": 362,
"creatinine_mg_dL": 0.95,
"alt_U_L": 49
},
{
"date": "2025-06-04T00:00:00",
"hemoglobin_g_dL": 10.1,
"wbc_k_uL": 5.3,
"platelets_k_uL": 351,
"creatinine_mg_dL": 1.13,
"... |
ANODE_SYNTH_2025_9915 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR L858R",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 2.5,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 3
} | {
"age": 74,
"sex": "female",
"bmi": 24.4,
"smoking_pack_years": 0,
"ecog_performance_status": 0,
"comorbidities": [
"diabetes"
]
} | {
"primary_tumor_size_cm": 3.7,
"metastatic_sites": [
"pleura"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2020-04-13T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -23,
"peak_response_20wk_change_percent": -69
},
"pfs_months": 15.51
},
"second_line... | {
"overall_survival_months": 24.2,
"censored": false
} | [
{
"date": "2020-03-19T00:00:00",
"hemoglobin_g_dL": 11.5,
"wbc_k_uL": 8.4,
"platelets_k_uL": 361,
"creatinine_mg_dL": 1.19,
"alt_U_L": 42
},
{
"date": "2020-10-10T00:00:00",
"hemoglobin_g_dL": 13.7,
"wbc_k_uL": 5.4,
"platelets_k_uL": 235,
"creatinine_mg_dL": 1.2,
... |
ANODE_SYNTH_2025_9916 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "EGFR L858R",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 12.7,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 14
} | {
"age": 75,
"sex": "female",
"bmi": 30.8,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": [
"diabetes",
"hyperlipidemia"
]
} | {
"primary_tumor_size_cm": 3.6,
"metastatic_sites": [
"brain"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2025-07-06T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -22,
"peak_response_20wk_change_percent": -45
},
"pfs_months": 17.25
},
"second_line... | {
"overall_survival_months": 34.8,
"censored": true
} | [
{
"date": "2025-06-19T00:00:00",
"hemoglobin_g_dL": 12.2,
"wbc_k_uL": 6.1,
"platelets_k_uL": 192,
"creatinine_mg_dL": 1.12,
"alt_U_L": 32
},
{
"date": "2026-01-02T00:00:00",
"hemoglobin_g_dL": 11.1,
"wbc_k_uL": 8.2,
"platelets_k_uL": 313,
"creatinine_mg_dL": 1.42,
... |
ANODE_SYNTH_2025_9917 | Non-small cell lung cancer | Squamous cell carcinoma | IV | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 2.5,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 18
} | {
"age": 76,
"sex": "male",
"bmi": 26.1,
"smoking_pack_years": 67,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 7.5,
"metastatic_sites": [
"bone"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2024-08-29T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -32,
"peak_response_20wk_change_percent": -36
},
"pfs_months": 25.72
... | {
"overall_survival_months": 36.9,
"censored": true
} | [
{
"date": "2024-08-15T00:00:00",
"hemoglobin_g_dL": 11.7,
"wbc_k_uL": 4.5,
"platelets_k_uL": 377,
"creatinine_mg_dL": 0.8,
"alt_U_L": 80
},
{
"date": "2025-02-25T00:00:00",
"hemoglobin_g_dL": 13.3,
"wbc_k_uL": 6.7,
"platelets_k_uL": 236,
"creatinine_mg_dL": 1.45,
... |
ANODE_SYNTH_2025_9918 | Non-small cell lung cancer | Squamous cell carcinoma | IVB | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 9.8,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 3
} | {
"age": 62,
"sex": "female",
"bmi": 20.6,
"smoking_pack_years": 34,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 8.2,
"metastatic_sites": [
"contralateral lung",
"bone"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2025-11-30T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -59,
"peak_response_20wk_change_percent": -46
},
"pfs_months": 14.59
... | {
"overall_survival_months": 28.8,
"censored": false
} | [
{
"date": "2025-10-12T00:00:00",
"hemoglobin_g_dL": 12.6,
"wbc_k_uL": 6.3,
"platelets_k_uL": 188,
"creatinine_mg_dL": 0.72,
"alt_U_L": 62
},
{
"date": "2026-05-29T00:00:00",
"hemoglobin_g_dL": 11.5,
"wbc_k_uL": 4.3,
"platelets_k_uL": 361,
"creatinine_mg_dL": 0.83,
... |
ANODE_SYNTH_2025_9919 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 6.2,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 32
} | {
"age": 74,
"sex": "female",
"bmi": 35.2,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 6.1,
"metastatic_sites": [
"liver",
"brain"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2021-05-18T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -59,
"peak_response_20wk_change_percent": -34
},
"pfs_months": 22.47
},
"second_line... | {
"overall_survival_months": 41.5,
"censored": false
} | [
{
"date": "2021-04-02T00:00:00",
"hemoglobin_g_dL": 11.8,
"wbc_k_uL": 8.9,
"platelets_k_uL": 399,
"creatinine_mg_dL": 1.29,
"alt_U_L": 39
},
{
"date": "2021-11-14T00:00:00",
"hemoglobin_g_dL": 10.4,
"wbc_k_uL": 4.4,
"platelets_k_uL": 302,
"creatinine_mg_dL": 1.04,
... |
ANODE_SYNTH_2025_9920 | Non-small cell lung cancer | Squamous cell carcinoma | IVB | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 16.6,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 4
} | {
"age": 85,
"sex": "female",
"bmi": 22.4,
"smoking_pack_years": 26,
"ecog_performance_status": 2,
"comorbidities": [
"hyperlipidemia"
]
} | {
"primary_tumor_size_cm": 8.3,
"metastatic_sites": [
"contralateral lung",
"liver"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2024-12-01T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -14,
"peak_response_20wk_change_percent": -58
},
"pfs_months": 15.15
... | {
"overall_survival_months": 29.3,
"censored": false
} | [
{
"date": "2024-10-11T00:00:00",
"hemoglobin_g_dL": 12.5,
"wbc_k_uL": 9.1,
"platelets_k_uL": 368,
"creatinine_mg_dL": 1.15,
"alt_U_L": 63
},
{
"date": "2025-05-30T00:00:00",
"hemoglobin_g_dL": 12.9,
"wbc_k_uL": 4.1,
"platelets_k_uL": 195,
"creatinine_mg_dL": 0.91,
... |
ANODE_SYNTH_2025_9921 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR L858R",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 14.1,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 12
} | {
"age": 79,
"sex": "female",
"bmi": 31,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": [
"hypertension",
"COPD"
]
} | {
"primary_tumor_size_cm": 4.2,
"metastatic_sites": [
"bone"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2021-06-16T00:00:00",
"best_response": "Stable disease",
"radiologic_response": {
"first_ct_8wk_change_percent": -27,
"peak_response_20wk_change_percent": -75
},
"pfs_months": 15.08
},
"second_line_t... | {
"overall_survival_months": 28.6,
"censored": true
} | [
{
"date": "2021-04-10T00:00:00",
"hemoglobin_g_dL": 12,
"wbc_k_uL": 6.8,
"platelets_k_uL": 194,
"creatinine_mg_dL": 0.73,
"alt_U_L": 37
},
{
"date": "2021-12-13T00:00:00",
"hemoglobin_g_dL": 13,
"wbc_k_uL": 4.4,
"platelets_k_uL": 247,
"creatinine_mg_dL": 1.07,
"al... |
ANODE_SYNTH_2025_9922 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR L858R",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 13.5,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 21
} | {
"age": 81,
"sex": "female",
"bmi": 19.3,
"smoking_pack_years": 0,
"ecog_performance_status": 0,
"comorbidities": []
} | {
"primary_tumor_size_cm": 6.2,
"metastatic_sites": [
"brain"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2024-03-12T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -26,
"peak_response_20wk_change_percent": -81
},
"pfs_months": 33.08
},
"second_line... | {
"overall_survival_months": 48.9,
"censored": false
} | [
{
"date": "2024-01-12T00:00:00",
"hemoglobin_g_dL": 12.7,
"wbc_k_uL": 7,
"platelets_k_uL": 427,
"creatinine_mg_dL": 1,
"alt_U_L": 19
},
{
"date": "2024-09-08T00:00:00",
"hemoglobin_g_dL": 10.5,
"wbc_k_uL": 3.9,
"platelets_k_uL": 161,
"creatinine_mg_dL": 1.04,
"alt... |
ANODE_SYNTH_2025_9923 | Non-small cell lung cancer | Squamous cell carcinoma | IV | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 14.7,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 7
} | {
"age": 86,
"sex": "male",
"bmi": 32,
"smoking_pack_years": 14,
"ecog_performance_status": 1,
"comorbidities": [
"diabetes",
"COPD"
]
} | {
"primary_tumor_size_cm": 6.5,
"metastatic_sites": [
"bone"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2024-06-19T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -17,
"peak_response_20wk_change_percent": -67
},
"pfs_months": 35.98
... | {
"overall_survival_months": 57.3,
"censored": false
} | [
{
"date": "2024-05-04T00:00:00",
"hemoglobin_g_dL": 14,
"wbc_k_uL": 5,
"platelets_k_uL": 270,
"creatinine_mg_dL": 1.18,
"alt_U_L": 21
},
{
"date": "2024-12-16T00:00:00",
"hemoglobin_g_dL": 12.9,
"wbc_k_uL": 6.2,
"platelets_k_uL": 214,
"creatinine_mg_dL": 1.28,
"al... |
ANODE_SYNTH_2025_9924 | Non-small cell lung cancer | Squamous cell carcinoma | IV | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 3.6,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 26
} | {
"age": 61,
"sex": "male",
"bmi": 22.3,
"smoking_pack_years": 20,
"ecog_performance_status": 2,
"comorbidities": [
"hyperlipidemia",
"diabetes"
]
} | {
"primary_tumor_size_cm": 4.5,
"metastatic_sites": [
"pleura"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2021-05-19T00:00:00",
"best_response": "Stable disease",
"radiologic_response": {
"first_ct_8wk_change_percent": -27,
"peak_response_20wk_change_percent": -84
},
"pfs_months": 28.22
},... | {
"overall_survival_months": 48.7,
"censored": true
} | [
{
"date": "2021-04-08T00:00:00",
"hemoglobin_g_dL": 14.7,
"wbc_k_uL": 4.7,
"platelets_k_uL": 402,
"creatinine_mg_dL": 0.91,
"alt_U_L": 76
},
{
"date": "2021-11-15T00:00:00",
"hemoglobin_g_dL": 12,
"wbc_k_uL": 6.2,
"platelets_k_uL": 203,
"creatinine_mg_dL": 0.97,
"... |
ANODE_SYNTH_2025_9925 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 3.6,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 29
} | {
"age": 48,
"sex": "male",
"bmi": 23.3,
"smoking_pack_years": 68,
"ecog_performance_status": 0,
"comorbidities": [
"hypertension",
"hyperlipidemia"
]
} | {
"primary_tumor_size_cm": 3.9,
"metastatic_sites": [
"bone",
"liver",
"contralateral lung"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2025-11-02T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -16,
"peak_response_20wk_change_percent": -60
},
"pfs_months": 34.6
},
"second_line_the... | {
"overall_survival_months": 62.7,
"censored": false
} | [
{
"date": "2025-09-12T00:00:00",
"hemoglobin_g_dL": 14.3,
"wbc_k_uL": 8.9,
"platelets_k_uL": 201,
"creatinine_mg_dL": 1.29,
"alt_U_L": 30
},
{
"date": "2026-05-01T00:00:00",
"hemoglobin_g_dL": 11.1,
"wbc_k_uL": 4.7,
"platelets_k_uL": 362,
"creatinine_mg_dL": 0.74,
... |
ANODE_SYNTH_2025_9926 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 10.2,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 29
} | {
"age": 73,
"sex": "female",
"bmi": 31.5,
"smoking_pack_years": 18,
"ecog_performance_status": 1,
"comorbidities": [
"COPD",
"hypertension"
]
} | {
"primary_tumor_size_cm": 3.8,
"metastatic_sites": [
"bone",
"pleura",
"contralateral lung"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2020-12-18T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -35,
"peak_response_20wk_change_percent": -43
},
"pfs_months": 2.96
},
"second_line_t... | {
"overall_survival_months": 11.7,
"censored": false
} | [
{
"date": "2020-10-18T00:00:00",
"hemoglobin_g_dL": 14.1,
"wbc_k_uL": 10.4,
"platelets_k_uL": 218,
"creatinine_mg_dL": 1.19,
"alt_U_L": 23
},
{
"date": "2021-06-16T00:00:00",
"hemoglobin_g_dL": 10.1,
"wbc_k_uL": 7.5,
"platelets_k_uL": 337,
"creatinine_mg_dL": 1.15,
... |
ANODE_SYNTH_2025_9927 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR L858R",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 11.7,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 5
} | {
"age": 86,
"sex": "female",
"bmi": 37.2,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": [
"hyperlipidemia",
"diabetes"
]
} | {
"primary_tumor_size_cm": 7.7,
"metastatic_sites": [
"contralateral lung",
"pleura",
"brain"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2025-10-06T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -55,
"peak_response_20wk_change_percent": -63
},
"pfs_months": 15.67
},
"second_line... | {
"overall_survival_months": 29.1,
"censored": false
} | [
{
"date": "2025-08-19T00:00:00",
"hemoglobin_g_dL": 14.5,
"wbc_k_uL": 10.3,
"platelets_k_uL": 330,
"creatinine_mg_dL": 1.01,
"alt_U_L": 50
},
{
"date": "2026-04-04T00:00:00",
"hemoglobin_g_dL": 13.4,
"wbc_k_uL": 7.7,
"platelets_k_uL": 218,
"creatinine_mg_dL": 1.31,
... |
ANODE_SYNTH_2025_9928 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 8.8,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 33
} | {
"age": 68,
"sex": "male",
"bmi": 32.7,
"smoking_pack_years": 51,
"ecog_performance_status": 1,
"comorbidities": [
"diabetes",
"hypertension"
]
} | {
"primary_tumor_size_cm": 4.2,
"metastatic_sites": [
"brain",
"pleura",
"bone"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2024-06-10T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -18,
"peak_response_20wk_change_percent": -46
},
"pfs_months": 35.91
},
"second_line_th... | {
"overall_survival_months": 59.3,
"censored": true
} | [
{
"date": "2024-04-01T00:00:00",
"hemoglobin_g_dL": 12,
"wbc_k_uL": 5.6,
"platelets_k_uL": 215,
"creatinine_mg_dL": 0.69,
"alt_U_L": 28
},
{
"date": "2024-12-07T00:00:00",
"hemoglobin_g_dL": 10.4,
"wbc_k_uL": 5.7,
"platelets_k_uL": 144,
"creatinine_mg_dL": 1.11,
"... |
ANODE_SYNTH_2025_9929 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 3.9,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 8
} | {
"age": 87,
"sex": "female",
"bmi": 33.3,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 4.3,
"metastatic_sites": [
"bone",
"liver"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2025-06-16T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -17,
"peak_response_20wk_change_percent": -60
},
"pfs_months": 36.3
},
"second_line_... | {
"overall_survival_months": 58.7,
"censored": false
} | [
{
"date": "2025-04-22T00:00:00",
"hemoglobin_g_dL": 13.3,
"wbc_k_uL": 10.6,
"platelets_k_uL": 198,
"creatinine_mg_dL": 0.79,
"alt_U_L": 62
},
{
"date": "2025-12-13T00:00:00",
"hemoglobin_g_dL": 12.6,
"wbc_k_uL": 4.3,
"platelets_k_uL": 259,
"creatinine_mg_dL": 1.41,
... |
ANODE_SYNTH_2025_9930 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 9.1,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 23
} | {
"age": 64,
"sex": "female",
"bmi": 31.2,
"smoking_pack_years": 25,
"ecog_performance_status": 2,
"comorbidities": [
"hypertension"
]
} | {
"primary_tumor_size_cm": 7.1,
"metastatic_sites": [
"brain",
"bone",
"pleura"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2020-12-01T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -48,
"peak_response_20wk_change_percent": -66
},
"pfs_months": 13.24
},
"second_line_... | {
"overall_survival_months": 17.2,
"censored": false
} | [
{
"date": "2020-11-15T00:00:00",
"hemoglobin_g_dL": 12.3,
"wbc_k_uL": 11,
"platelets_k_uL": 226,
"creatinine_mg_dL": 1.29,
"alt_U_L": 21
},
{
"date": "2021-05-30T00:00:00",
"hemoglobin_g_dL": 11.1,
"wbc_k_uL": 4.1,
"platelets_k_uL": 294,
"creatinine_mg_dL": 1.45,
... |
ANODE_SYNTH_2025_9931 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 4.1,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 0
} | {
"age": 77,
"sex": "female",
"bmi": 29.8,
"smoking_pack_years": 65,
"ecog_performance_status": 0,
"comorbidities": [
"COPD",
"hyperlipidemia"
]
} | {
"primary_tumor_size_cm": 4.3,
"metastatic_sites": [
"contralateral lung",
"brain",
"pleura"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2025-04-30T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -32,
"peak_response_20wk_change_percent": -51
},
"pfs_months": 16.76
},
"second_line_... | {
"overall_survival_months": 20.9,
"censored": false
} | [
{
"date": "2025-02-26T00:00:00",
"hemoglobin_g_dL": 15,
"wbc_k_uL": 7.9,
"platelets_k_uL": 419,
"creatinine_mg_dL": 0.7,
"alt_U_L": 74
},
{
"date": "2025-10-27T00:00:00",
"hemoglobin_g_dL": 10.8,
"wbc_k_uL": 8,
"platelets_k_uL": 176,
"creatinine_mg_dL": 0.88,
"alt... |
ANODE_SYNTH_2025_9932 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR L858R",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 13.6,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 9
} | {
"age": 57,
"sex": "female",
"bmi": 25.1,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": [
"hypertension"
]
} | {
"primary_tumor_size_cm": 7.3,
"metastatic_sites": [
"liver",
"contralateral lung",
"bone"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2025-07-28T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -20,
"peak_response_20wk_change_percent": -50
},
"pfs_months": 26.94
},
"second_line... | {
"overall_survival_months": 32.7,
"censored": false
} | [
{
"date": "2025-07-08T00:00:00",
"hemoglobin_g_dL": 12.5,
"wbc_k_uL": 9.4,
"platelets_k_uL": 426,
"creatinine_mg_dL": 1.06,
"alt_U_L": 20
},
{
"date": "2026-01-24T00:00:00",
"hemoglobin_g_dL": 11.4,
"wbc_k_uL": 6.6,
"platelets_k_uL": 204,
"creatinine_mg_dL": 0.72,
... |
ANODE_SYNTH_2025_9933 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 6.9,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 16
} | {
"age": 69,
"sex": "male",
"bmi": 32.3,
"smoking_pack_years": 72,
"ecog_performance_status": 1,
"comorbidities": [
"hyperlipidemia",
"diabetes"
]
} | {
"primary_tumor_size_cm": 4,
"metastatic_sites": [
"liver",
"brain"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2024-03-02T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -11,
"peak_response_20wk_change_percent": -30
},
"pfs_months": 37.72
},
"second_line_th... | {
"overall_survival_months": 58.9,
"censored": true
} | [
{
"date": "2024-02-13T00:00:00",
"hemoglobin_g_dL": 15.3,
"wbc_k_uL": 5.4,
"platelets_k_uL": 242,
"creatinine_mg_dL": 0.7,
"alt_U_L": 13
},
{
"date": "2024-08-29T00:00:00",
"hemoglobin_g_dL": 10.3,
"wbc_k_uL": 4.3,
"platelets_k_uL": 331,
"creatinine_mg_dL": 0.75,
... |
ANODE_SYNTH_2025_9934 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 3.6,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 17
} | {
"age": 85,
"sex": "male",
"bmi": 30.5,
"smoking_pack_years": 80,
"ecog_performance_status": 0,
"comorbidities": [
"COPD"
]
} | {
"primary_tumor_size_cm": 7,
"metastatic_sites": [
"liver",
"pleura"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2021-12-22T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -11,
"peak_response_20wk_change_percent": -36
},
"pfs_months": 39
},
"second_line_thera... | {
"overall_survival_months": 66.2,
"censored": false
} | [
{
"date": "2021-10-18T00:00:00",
"hemoglobin_g_dL": 13.9,
"wbc_k_uL": 8.9,
"platelets_k_uL": 302,
"creatinine_mg_dL": 1.19,
"alt_U_L": 37
},
{
"date": "2022-06-20T00:00:00",
"hemoglobin_g_dL": 13,
"wbc_k_uL": 6.2,
"platelets_k_uL": 338,
"creatinine_mg_dL": 1.51,
"... |
ANODE_SYNTH_2025_9935 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "EGFR L858R",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 5.6,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 21
} | {
"age": 81,
"sex": "female",
"bmi": 26.9,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 6.4,
"metastatic_sites": [
"pleura",
"contralateral lung"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2021-11-19T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -56,
"peak_response_20wk_change_percent": -83
},
"pfs_months": 18.86
},
"second_line... | {
"overall_survival_months": 41.1,
"censored": false
} | [
{
"date": "2021-10-24T00:00:00",
"hemoglobin_g_dL": 13.3,
"wbc_k_uL": 9.1,
"platelets_k_uL": 342,
"creatinine_mg_dL": 0.79,
"alt_U_L": 47
},
{
"date": "2022-05-18T00:00:00",
"hemoglobin_g_dL": 11.9,
"wbc_k_uL": 8.6,
"platelets_k_uL": 156,
"creatinine_mg_dL": 1.21,
... |
ANODE_SYNTH_2025_9936 | Non-small cell lung cancer | Squamous cell carcinoma | IV | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 4.4,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 22
} | {
"age": 66,
"sex": "female",
"bmi": 28.8,
"smoking_pack_years": 22,
"ecog_performance_status": 1,
"comorbidities": [
"COPD"
]
} | {
"primary_tumor_size_cm": 4.7,
"metastatic_sites": [
"liver",
"pleura",
"brain"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2020-03-30T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -51,
"peak_response_20wk_change_percent": -38
},
"pfs_months": 25.07
... | {
"overall_survival_months": 39.7,
"censored": true
} | [
{
"date": "2020-01-22T00:00:00",
"hemoglobin_g_dL": 15.4,
"wbc_k_uL": 4.8,
"platelets_k_uL": 393,
"creatinine_mg_dL": 0.65,
"alt_U_L": 60
},
{
"date": "2020-09-26T00:00:00",
"hemoglobin_g_dL": 12.2,
"wbc_k_uL": 4.3,
"platelets_k_uL": 272,
"creatinine_mg_dL": 0.73,
... |
ANODE_SYNTH_2025_9937 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 6.6,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 0
} | {
"age": 59,
"sex": "male",
"bmi": 29.8,
"smoking_pack_years": 77,
"ecog_performance_status": 1,
"comorbidities": [
"diabetes",
"hypertension"
]
} | {
"primary_tumor_size_cm": 6.2,
"metastatic_sites": [
"brain",
"contralateral lung"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2025-05-18T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -31,
"peak_response_20wk_change_percent": -79
},
"pfs_months": 45.27
},
"second_line_th... | {
"overall_survival_months": 66.7,
"censored": false
} | [
{
"date": "2025-03-12T00:00:00",
"hemoglobin_g_dL": 12,
"wbc_k_uL": 10.6,
"platelets_k_uL": 368,
"creatinine_mg_dL": 0.68,
"alt_U_L": 72
},
{
"date": "2025-11-14T00:00:00",
"hemoglobin_g_dL": 13.3,
"wbc_k_uL": 6.5,
"platelets_k_uL": 204,
"creatinine_mg_dL": 0.87,
... |
ANODE_SYNTH_2025_9938 | Non-small cell lung cancer | Squamous cell carcinoma | IV | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 10.9,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 32
} | {
"age": 77,
"sex": "male",
"bmi": 27.4,
"smoking_pack_years": 15,
"ecog_performance_status": 1,
"comorbidities": [
"hyperlipidemia",
"diabetes"
]
} | {
"primary_tumor_size_cm": 5.3,
"metastatic_sites": [
"contralateral lung"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2021-02-03T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -51,
"peak_response_20wk_change_percent": -70
},
"pfs_months": 17.12
... | {
"overall_survival_months": 35.9,
"censored": true
} | [
{
"date": "2021-01-06T00:00:00",
"hemoglobin_g_dL": 14.9,
"wbc_k_uL": 6.8,
"platelets_k_uL": 307,
"creatinine_mg_dL": 1.29,
"alt_U_L": 27
},
{
"date": "2021-08-02T00:00:00",
"hemoglobin_g_dL": 13.4,
"wbc_k_uL": 4.7,
"platelets_k_uL": 234,
"creatinine_mg_dL": 0.96,
... |
ANODE_SYNTH_2025_9939 | Non-small cell lung cancer | Squamous cell carcinoma | IV | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 15.5,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 33
} | {
"age": 88,
"sex": "male",
"bmi": 23.5,
"smoking_pack_years": 56,
"ecog_performance_status": 0,
"comorbidities": []
} | {
"primary_tumor_size_cm": 4.2,
"metastatic_sites": [
"contralateral lung",
"liver",
"brain"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2025-01-17T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -52,
"peak_response_20wk_change_percent": -63
},
"pfs_months": 18.86
... | {
"overall_survival_months": 28.9,
"censored": false
} | [
{
"date": "2024-11-26T00:00:00",
"hemoglobin_g_dL": 14,
"wbc_k_uL": 8.3,
"platelets_k_uL": 204,
"creatinine_mg_dL": 0.99,
"alt_U_L": 41
},
{
"date": "2025-07-16T00:00:00",
"hemoglobin_g_dL": 12.5,
"wbc_k_uL": 5.9,
"platelets_k_uL": 380,
"creatinine_mg_dL": 0.98,
"... |
ANODE_SYNTH_2025_9940 | Non-small cell lung cancer | Squamous cell carcinoma | IVB | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 7.6,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 23
} | {
"age": 72,
"sex": "female",
"bmi": 31.9,
"smoking_pack_years": 78,
"ecog_performance_status": 1,
"comorbidities": [
"diabetes"
]
} | {
"primary_tumor_size_cm": 7.2,
"metastatic_sites": [
"contralateral lung",
"pleura",
"brain"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2025-11-22T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -57,
"peak_response_20wk_change_percent": -35
},
"pfs_months": 32.69
... | {
"overall_survival_months": 54.9,
"censored": false
} | [
{
"date": "2025-10-20T00:00:00",
"hemoglobin_g_dL": 13.2,
"wbc_k_uL": 6.4,
"platelets_k_uL": 256,
"creatinine_mg_dL": 0.95,
"alt_U_L": 26
},
{
"date": "2026-05-21T00:00:00",
"hemoglobin_g_dL": 10.8,
"wbc_k_uL": 6.6,
"platelets_k_uL": 376,
"creatinine_mg_dL": 0.73,
... |
ANODE_SYNTH_2025_9941 | Non-small cell lung cancer | Squamous cell carcinoma | IV | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 17.6,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 33
} | {
"age": 84,
"sex": "male",
"bmi": 28.2,
"smoking_pack_years": 48,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 6.4,
"metastatic_sites": [
"liver"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2023-03-08T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -38,
"peak_response_20wk_change_percent": -76
},
"pfs_months": 25.86
... | {
"overall_survival_months": 34.7,
"censored": true
} | [
{
"date": "2023-02-13T00:00:00",
"hemoglobin_g_dL": 12.6,
"wbc_k_uL": 9.9,
"platelets_k_uL": 206,
"creatinine_mg_dL": 1.28,
"alt_U_L": 36
},
{
"date": "2023-09-04T00:00:00",
"hemoglobin_g_dL": 11.4,
"wbc_k_uL": 8.3,
"platelets_k_uL": 163,
"creatinine_mg_dL": 0.77,
... |
ANODE_SYNTH_2025_9942 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "EGFR L858R",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 6.9,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 3
} | {
"age": 59,
"sex": "female",
"bmi": 36.8,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 6.1,
"metastatic_sites": [
"bone",
"liver"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2020-07-17T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -47,
"peak_response_20wk_change_percent": -77
},
"pfs_months": 24.28
},
"second_line... | {
"overall_survival_months": 39.8,
"censored": false
} | [
{
"date": "2020-06-26T00:00:00",
"hemoglobin_g_dL": 12.6,
"wbc_k_uL": 7.9,
"platelets_k_uL": 181,
"creatinine_mg_dL": 0.91,
"alt_U_L": 48
},
{
"date": "2021-01-13T00:00:00",
"hemoglobin_g_dL": 10.5,
"wbc_k_uL": 3.9,
"platelets_k_uL": 157,
"creatinine_mg_dL": 1.59,
... |
ANODE_SYNTH_2025_9943 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 4,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 13
} | {
"age": 59,
"sex": "male",
"bmi": 21.6,
"smoking_pack_years": 15,
"ecog_performance_status": 1,
"comorbidities": [
"hyperlipidemia",
"diabetes"
]
} | {
"primary_tumor_size_cm": 4.2,
"metastatic_sites": [
"liver",
"brain"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2023-11-13T00:00:00",
"best_response": "Stable disease",
"radiologic_response": {
"first_ct_8wk_change_percent": -58,
"peak_response_20wk_change_percent": -41
},
"pfs_months": 21.91
},
"second_line_th... | {
"overall_survival_months": 35.3,
"censored": false
} | [
{
"date": "2023-09-04T00:00:00",
"hemoglobin_g_dL": 14.2,
"wbc_k_uL": 5.2,
"platelets_k_uL": 385,
"creatinine_mg_dL": 0.84,
"alt_U_L": 41
},
{
"date": "2024-05-11T00:00:00",
"hemoglobin_g_dL": 10.6,
"wbc_k_uL": 8.9,
"platelets_k_uL": 229,
"creatinine_mg_dL": 1.39,
... |
ANODE_SYNTH_2025_9944 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 12.6,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 30
} | {
"age": 69,
"sex": "female",
"bmi": 23.9,
"smoking_pack_years": 0,
"ecog_performance_status": 0,
"comorbidities": []
} | {
"primary_tumor_size_cm": 6.1,
"metastatic_sites": [
"brain"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2022-01-07T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -18,
"peak_response_20wk_change_percent": -79
},
"pfs_months": 29.14
},
"second_line... | {
"overall_survival_months": 41.2,
"censored": false
} | [
{
"date": "2021-11-19T00:00:00",
"hemoglobin_g_dL": 15.5,
"wbc_k_uL": 6,
"platelets_k_uL": 315,
"creatinine_mg_dL": 1.18,
"alt_U_L": 38
},
{
"date": "2022-07-06T00:00:00",
"hemoglobin_g_dL": 10.8,
"wbc_k_uL": 5.7,
"platelets_k_uL": 232,
"creatinine_mg_dL": 1.36,
"... |
ANODE_SYNTH_2025_9945 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 7.2,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 16
} | {
"age": 60,
"sex": "female",
"bmi": 31.6,
"smoking_pack_years": 47,
"ecog_performance_status": 1,
"comorbidities": [
"COPD"
]
} | {
"primary_tumor_size_cm": 6.9,
"metastatic_sites": [
"brain",
"contralateral lung"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2020-04-22T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -34,
"peak_response_20wk_change_percent": -76
},
"pfs_months": 34.07
},
"second_line_th... | {
"overall_survival_months": 57.6,
"censored": false
} | [
{
"date": "2020-04-07T00:00:00",
"hemoglobin_g_dL": 11.7,
"wbc_k_uL": 6.1,
"platelets_k_uL": 170,
"creatinine_mg_dL": 1.16,
"alt_U_L": 11
},
{
"date": "2020-10-19T00:00:00",
"hemoglobin_g_dL": 11.3,
"wbc_k_uL": 3.9,
"platelets_k_uL": 300,
"creatinine_mg_dL": 0.77,
... |
ANODE_SYNTH_2025_9946 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 13.3,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 8
} | {
"age": 74,
"sex": "female",
"bmi": 18.8,
"smoking_pack_years": 42,
"ecog_performance_status": 1,
"comorbidities": [
"COPD"
]
} | {
"primary_tumor_size_cm": 3.8,
"metastatic_sites": [
"pleura"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2020-04-05T00:00:00",
"best_response": "Stable disease",
"radiologic_response": {
"first_ct_8wk_change_percent": -22,
"peak_response_20wk_change_percent": -77
},
"pfs_months": 13.86
},
"second_line_th... | {
"overall_survival_months": 18.1,
"censored": false
} | [
{
"date": "2020-01-28T00:00:00",
"hemoglobin_g_dL": 15.4,
"wbc_k_uL": 5,
"platelets_k_uL": 404,
"creatinine_mg_dL": 1.28,
"alt_U_L": 18
},
{
"date": "2020-10-02T00:00:00",
"hemoglobin_g_dL": 13.7,
"wbc_k_uL": 5,
"platelets_k_uL": 154,
"creatinine_mg_dL": 0.93,
"al... |
ANODE_SYNTH_2025_9947 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 17.4,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 19
} | {
"age": 55,
"sex": "female",
"bmi": 30.4,
"smoking_pack_years": 28,
"ecog_performance_status": 0,
"comorbidities": []
} | {
"primary_tumor_size_cm": 3.9,
"metastatic_sites": [
"bone",
"contralateral lung"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2025-01-31T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -42,
"peak_response_20wk_change_percent": -47
},
"pfs_months": 39.2
},
"second_line_the... | {
"overall_survival_months": 68.9,
"censored": false
} | [
{
"date": "2024-12-12T00:00:00",
"hemoglobin_g_dL": 13.6,
"wbc_k_uL": 4.6,
"platelets_k_uL": 304,
"creatinine_mg_dL": 1.22,
"alt_U_L": 55
},
{
"date": "2025-07-30T00:00:00",
"hemoglobin_g_dL": 10.5,
"wbc_k_uL": 6.6,
"platelets_k_uL": 343,
"creatinine_mg_dL": 1.16,
... |
ANODE_SYNTH_2025_9948 | Non-small cell lung cancer | Squamous cell carcinoma | IV | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 4.3,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 26
} | {
"age": 50,
"sex": "female",
"bmi": 31.5,
"smoking_pack_years": 60,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 7.1,
"metastatic_sites": [
"brain",
"contralateral lung",
"pleura"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2024-02-02T00:00:00",
"best_response": "Stable disease",
"radiologic_response": {
"first_ct_8wk_change_percent": -15,
"peak_response_20wk_change_percent": -71
},
"pfs_months": 14.55
},... | {
"overall_survival_months": 24.9,
"censored": false
} | [
{
"date": "2023-11-28T00:00:00",
"hemoglobin_g_dL": 14,
"wbc_k_uL": 6.8,
"platelets_k_uL": 161,
"creatinine_mg_dL": 0.74,
"alt_U_L": 59
},
{
"date": "2024-07-31T00:00:00",
"hemoglobin_g_dL": 13.4,
"wbc_k_uL": 4.7,
"platelets_k_uL": 334,
"creatinine_mg_dL": 1.18,
"... |
ANODE_SYNTH_2025_9949 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 4.8,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 14
} | {
"age": 55,
"sex": "female",
"bmi": 29.5,
"smoking_pack_years": 39,
"ecog_performance_status": 2,
"comorbidities": [
"COPD"
]
} | {
"primary_tumor_size_cm": 5.6,
"metastatic_sites": [
"liver",
"contralateral lung"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2024-04-01T00:00:00",
"best_response": "Stable disease",
"radiologic_response": {
"first_ct_8wk_change_percent": -20,
"peak_response_20wk_change_percent": -70
},
"pfs_months": 6.18
},
"second_line_the... | {
"overall_survival_months": 10.1,
"censored": true
} | [
{
"date": "2024-02-06T00:00:00",
"hemoglobin_g_dL": 12.7,
"wbc_k_uL": 10,
"platelets_k_uL": 365,
"creatinine_mg_dL": 0.69,
"alt_U_L": 72
},
{
"date": "2024-09-28T00:00:00",
"hemoglobin_g_dL": 10.1,
"wbc_k_uL": 5,
"platelets_k_uL": 271,
"creatinine_mg_dL": 1.28,
"a... |
ANODE_SYNTH_2025_9950 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 3.3,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 12
} | {
"age": 84,
"sex": "female",
"bmi": 21.7,
"smoking_pack_years": 62,
"ecog_performance_status": 1,
"comorbidities": [
"hypertension",
"diabetes"
]
} | {
"primary_tumor_size_cm": 6.8,
"metastatic_sites": [
"liver"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2025-08-06T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -41,
"peak_response_20wk_change_percent": -52
},
"pfs_months": 14.52
},
"second_line_... | {
"overall_survival_months": 25.1,
"censored": false
} | [
{
"date": "2025-07-02T00:00:00",
"hemoglobin_g_dL": 14.9,
"wbc_k_uL": 6.4,
"platelets_k_uL": 305,
"creatinine_mg_dL": 1.22,
"alt_U_L": 36
},
{
"date": "2026-02-02T00:00:00",
"hemoglobin_g_dL": 10.8,
"wbc_k_uL": 5.4,
"platelets_k_uL": 268,
"creatinine_mg_dL": 0.89,
... |
ANODE_SYNTH_2025_9951 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 2.8,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 6
} | {
"age": 59,
"sex": "male",
"bmi": 20.4,
"smoking_pack_years": 13,
"ecog_performance_status": 1,
"comorbidities": [
"hypertension",
"COPD"
]
} | {
"primary_tumor_size_cm": 5.4,
"metastatic_sites": [
"liver",
"bone"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2021-06-06T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -28,
"peak_response_20wk_change_percent": -54
},
"pfs_months": 10.05
},
"second_line_... | {
"overall_survival_months": 14,
"censored": true
} | [
{
"date": "2021-04-01T00:00:00",
"hemoglobin_g_dL": 11.6,
"wbc_k_uL": 8.5,
"platelets_k_uL": 394,
"creatinine_mg_dL": 1.12,
"alt_U_L": 39
},
{
"date": "2021-12-03T00:00:00",
"hemoglobin_g_dL": 12.8,
"wbc_k_uL": 8.9,
"platelets_k_uL": 279,
"creatinine_mg_dL": 1,
"a... |
ANODE_SYNTH_2025_9952 | Non-small cell lung cancer | Squamous cell carcinoma | IV | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 10.5,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 25
} | {
"age": 74,
"sex": "male",
"bmi": 25.6,
"smoking_pack_years": 25,
"ecog_performance_status": 1,
"comorbidities": [
"hypertension",
"COPD"
]
} | {
"primary_tumor_size_cm": 8.3,
"metastatic_sites": [
"contralateral lung",
"bone"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2023-06-23T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -59,
"peak_response_20wk_change_percent": -56
},
"pfs_months": 38.83
... | {
"overall_survival_months": 57.9,
"censored": false
} | [
{
"date": "2023-06-04T00:00:00",
"hemoglobin_g_dL": 15.3,
"wbc_k_uL": 10.5,
"platelets_k_uL": 293,
"creatinine_mg_dL": 0.93,
"alt_U_L": 66
},
{
"date": "2023-12-20T00:00:00",
"hemoglobin_g_dL": 10.3,
"wbc_k_uL": 7.9,
"platelets_k_uL": 298,
"creatinine_mg_dL": 1.53,
... |
ANODE_SYNTH_2025_9953 | Non-small cell lung cancer | Squamous cell carcinoma | IV | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 8.1,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 22
} | {
"age": 68,
"sex": "male",
"bmi": 29.5,
"smoking_pack_years": 69,
"ecog_performance_status": 1,
"comorbidities": [
"diabetes"
]
} | {
"primary_tumor_size_cm": 7.3,
"metastatic_sites": [
"contralateral lung",
"brain"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2023-10-09T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -24,
"peak_response_20wk_change_percent": -81
},
"pfs_months": 28.22
... | {
"overall_survival_months": 39,
"censored": true
} | [
{
"date": "2023-09-11T00:00:00",
"hemoglobin_g_dL": 11.7,
"wbc_k_uL": 8.9,
"platelets_k_uL": 397,
"creatinine_mg_dL": 1.13,
"alt_U_L": 34
},
{
"date": "2024-04-06T00:00:00",
"hemoglobin_g_dL": 12.7,
"wbc_k_uL": 5.7,
"platelets_k_uL": 324,
"creatinine_mg_dL": 0.82,
... |
ANODE_SYNTH_2025_9954 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 4.9,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 1
} | {
"age": 72,
"sex": "female",
"bmi": 25.9,
"smoking_pack_years": 61,
"ecog_performance_status": 1,
"comorbidities": [
"hypertension",
"hyperlipidemia"
]
} | {
"primary_tumor_size_cm": 5.7,
"metastatic_sites": [
"liver",
"contralateral lung"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2024-05-07T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -24,
"peak_response_20wk_change_percent": -42
},
"pfs_months": 2.96
},
"second_line_t... | {
"overall_survival_months": 9.3,
"censored": false
} | [
{
"date": "2024-04-11T00:00:00",
"hemoglobin_g_dL": 13.7,
"wbc_k_uL": 4.8,
"platelets_k_uL": 278,
"creatinine_mg_dL": 1.29,
"alt_U_L": 49
},
{
"date": "2024-11-03T00:00:00",
"hemoglobin_g_dL": 13.4,
"wbc_k_uL": 8.6,
"platelets_k_uL": 122,
"creatinine_mg_dL": 1.57,
... |
ANODE_SYNTH_2025_9955 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR L858R",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 17.3,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 19
} | {
"age": 75,
"sex": "female",
"bmi": 37.6,
"smoking_pack_years": 0,
"ecog_performance_status": 0,
"comorbidities": [
"diabetes"
]
} | {
"primary_tumor_size_cm": 4.1,
"metastatic_sites": [
"liver"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2024-01-12T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -42,
"peak_response_20wk_change_percent": -77
},
"pfs_months": 23.62
},
"second_line... | {
"overall_survival_months": 35.1,
"censored": true
} | [
{
"date": "2023-11-28T00:00:00",
"hemoglobin_g_dL": 15,
"wbc_k_uL": 5.5,
"platelets_k_uL": 301,
"creatinine_mg_dL": 0.74,
"alt_U_L": 32
},
{
"date": "2024-07-10T00:00:00",
"hemoglobin_g_dL": 13.2,
"wbc_k_uL": 7.4,
"platelets_k_uL": 260,
"creatinine_mg_dL": 1.53,
"... |
ANODE_SYNTH_2025_9956 | Non-small cell lung cancer | Squamous cell carcinoma | IVB | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 7.2,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 21
} | {
"age": 68,
"sex": "male",
"bmi": 36.2,
"smoking_pack_years": 45,
"ecog_performance_status": 0,
"comorbidities": [
"diabetes"
]
} | {
"primary_tumor_size_cm": 5.9,
"metastatic_sites": [
"pleura",
"liver",
"contralateral lung"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2020-11-10T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -16,
"peak_response_20wk_change_percent": -64
},
"pfs_months": 23.69
... | {
"overall_survival_months": 40.9,
"censored": false
} | [
{
"date": "2020-10-24T00:00:00",
"hemoglobin_g_dL": 13.6,
"wbc_k_uL": 4.6,
"platelets_k_uL": 271,
"creatinine_mg_dL": 0.62,
"alt_U_L": 58
},
{
"date": "2021-05-09T00:00:00",
"hemoglobin_g_dL": 12.2,
"wbc_k_uL": 8.8,
"platelets_k_uL": 198,
"creatinine_mg_dL": 1.36,
... |
ANODE_SYNTH_2025_9957 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "NTRK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 13.6,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 32
} | {
"age": 85,
"sex": "female",
"bmi": 19.9,
"smoking_pack_years": 66,
"ecog_performance_status": 1,
"comorbidities": [
"hypertension"
]
} | {
"primary_tumor_size_cm": 6.6,
"metastatic_sites": [
"liver",
"contralateral lung",
"brain"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "larotrectinib 100 mg BID",
"start_date": "2022-04-23T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -29,
"peak_response_20wk_change_percent": -51
},
"pfs_months": 40.15
},
"second_lin... | {
"overall_survival_months": 73.4,
"censored": false
} | [
{
"date": "2022-03-01T00:00:00",
"hemoglobin_g_dL": 12,
"wbc_k_uL": 4.6,
"platelets_k_uL": 276,
"creatinine_mg_dL": 0.95,
"alt_U_L": 52
},
{
"date": "2022-10-20T00:00:00",
"hemoglobin_g_dL": 12.2,
"wbc_k_uL": 8.9,
"platelets_k_uL": 327,
"creatinine_mg_dL": 0.74,
"... |
ANODE_SYNTH_2025_9958 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 6.9,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 24
} | {
"age": 50,
"sex": "male",
"bmi": 35.3,
"smoking_pack_years": 70,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 4.9,
"metastatic_sites": [
"contralateral lung"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2021-10-08T00:00:00",
"best_response": "Stable disease",
"radiologic_response": {
"first_ct_8wk_change_percent": -60,
"peak_response_20wk_change_percent": -76
},
"pfs_months": 35.94
},
"second_line_ther... | {
"overall_survival_months": 64.8,
"censored": false
} | [
{
"date": "2021-08-25T00:00:00",
"hemoglobin_g_dL": 14.2,
"wbc_k_uL": 6.9,
"platelets_k_uL": 302,
"creatinine_mg_dL": 1.2,
"alt_U_L": 55
},
{
"date": "2022-04-06T00:00:00",
"hemoglobin_g_dL": 10.9,
"wbc_k_uL": 4.8,
"platelets_k_uL": 239,
"creatinine_mg_dL": 1.59,
... |
ANODE_SYNTH_2025_9959 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR L858R",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 10.2,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 9
} | {
"age": 61,
"sex": "female",
"bmi": 34,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": [
"hypertension"
]
} | {
"primary_tumor_size_cm": 6.5,
"metastatic_sites": [
"liver"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2024-10-19T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -21,
"peak_response_20wk_change_percent": -62
},
"pfs_months": 20.93
},
"second_line... | {
"overall_survival_months": 30,
"censored": false
} | [
{
"date": "2024-09-24T00:00:00",
"hemoglobin_g_dL": 14.8,
"wbc_k_uL": 7.3,
"platelets_k_uL": 207,
"creatinine_mg_dL": 0.87,
"alt_U_L": 54
},
{
"date": "2025-04-17T00:00:00",
"hemoglobin_g_dL": 12.8,
"wbc_k_uL": 5.1,
"platelets_k_uL": 266,
"creatinine_mg_dL": 0.87,
... |
ANODE_SYNTH_2025_9960 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR L858R",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 3,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 21
} | {
"age": 80,
"sex": "female",
"bmi": 33.3,
"smoking_pack_years": 0,
"ecog_performance_status": 0,
"comorbidities": []
} | {
"primary_tumor_size_cm": 5,
"metastatic_sites": [
"liver",
"bone",
"contralateral lung"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2024-04-17T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -27,
"peak_response_20wk_change_percent": -77
},
"pfs_months": 21.95
},
"second_line... | {
"overall_survival_months": 43.8,
"censored": false
} | [
{
"date": "2024-02-22T00:00:00",
"hemoglobin_g_dL": 11.7,
"wbc_k_uL": 8.4,
"platelets_k_uL": 412,
"creatinine_mg_dL": 1.01,
"alt_U_L": 17
},
{
"date": "2024-10-14T00:00:00",
"hemoglobin_g_dL": 13,
"wbc_k_uL": 7.5,
"platelets_k_uL": 223,
"creatinine_mg_dL": 1.07,
"... |
ANODE_SYNTH_2025_9961 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 16.8,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 24
} | {
"age": 83,
"sex": "male",
"bmi": 37.2,
"smoking_pack_years": 56,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 3.3,
"metastatic_sites": [
"bone",
"liver",
"brain"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2023-03-13T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -37,
"peak_response_20wk_change_percent": -82
},
"pfs_months": 39.98
},
"second_line_th... | {
"overall_survival_months": 60.8,
"censored": false
} | [
{
"date": "2023-02-03T00:00:00",
"hemoglobin_g_dL": 14.1,
"wbc_k_uL": 8.7,
"platelets_k_uL": 360,
"creatinine_mg_dL": 1.07,
"alt_U_L": 34
},
{
"date": "2023-09-09T00:00:00",
"hemoglobin_g_dL": 12.3,
"wbc_k_uL": 8.8,
"platelets_k_uL": 337,
"creatinine_mg_dL": 1.52,
... |
ANODE_SYNTH_2025_9962 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR L858R",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 14.7,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 30
} | {
"age": 68,
"sex": "female",
"bmi": 25,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": [
"hyperlipidemia"
]
} | {
"primary_tumor_size_cm": 5.2,
"metastatic_sites": [
"liver",
"contralateral lung",
"pleura"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2022-08-19T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -24,
"peak_response_20wk_change_percent": -68
},
"pfs_months": 16.16
},
"second_line... | {
"overall_survival_months": 30.8,
"censored": true
} | [
{
"date": "2022-07-09T00:00:00",
"hemoglobin_g_dL": 14.8,
"wbc_k_uL": 10.6,
"platelets_k_uL": 320,
"creatinine_mg_dL": 0.68,
"alt_U_L": 54
},
{
"date": "2023-02-15T00:00:00",
"hemoglobin_g_dL": 11.9,
"wbc_k_uL": 5.5,
"platelets_k_uL": 349,
"creatinine_mg_dL": 1.16,
... |
ANODE_SYNTH_2025_9963 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 4.8,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 19
} | {
"age": 66,
"sex": "female",
"bmi": 32.3,
"smoking_pack_years": 23,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 3.5,
"metastatic_sites": [
"pleura"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2022-10-02T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -51,
"peak_response_20wk_change_percent": -68
},
"pfs_months": 39.29
},
"second_line_th... | {
"overall_survival_months": 61.8,
"censored": false
} | [
{
"date": "2022-09-10T00:00:00",
"hemoglobin_g_dL": 12.3,
"wbc_k_uL": 6.6,
"platelets_k_uL": 349,
"creatinine_mg_dL": 1.18,
"alt_U_L": 38
},
{
"date": "2023-03-31T00:00:00",
"hemoglobin_g_dL": 10.8,
"wbc_k_uL": 6.4,
"platelets_k_uL": 178,
"creatinine_mg_dL": 0.92,
... |
ANODE_SYNTH_2025_9964 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 10.4,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 32
} | {
"age": 48,
"sex": "male",
"bmi": 23.6,
"smoking_pack_years": 16,
"ecog_performance_status": 2,
"comorbidities": []
} | {
"primary_tumor_size_cm": 4.3,
"metastatic_sites": [
"bone"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2025-11-25T00:00:00",
"best_response": "Stable disease",
"radiologic_response": {
"first_ct_8wk_change_percent": -53,
"peak_response_20wk_change_percent": -61
},
"pfs_months": 34.79
},
"second_line_ther... | {
"overall_survival_months": 58.2,
"censored": true
} | [
{
"date": "2025-10-20T00:00:00",
"hemoglobin_g_dL": 14.7,
"wbc_k_uL": 8.6,
"platelets_k_uL": 213,
"creatinine_mg_dL": 0.68,
"alt_U_L": 11
},
{
"date": "2026-05-24T00:00:00",
"hemoglobin_g_dL": 10.5,
"wbc_k_uL": 8.1,
"platelets_k_uL": 156,
"creatinine_mg_dL": 1.58,
... |
ANODE_SYNTH_2025_9965 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 10.2,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 11
} | {
"age": 60,
"sex": "male",
"bmi": 22.6,
"smoking_pack_years": 74,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 4.2,
"metastatic_sites": [
"bone"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2024-09-16T00:00:00",
"best_response": "Stable disease",
"radiologic_response": {
"first_ct_8wk_change_percent": -12,
"peak_response_20wk_change_percent": -42
},
"pfs_months": 41.66
},
"second_line_ther... | {
"overall_survival_months": 61.8,
"censored": false
} | [
{
"date": "2024-07-15T00:00:00",
"hemoglobin_g_dL": 13.9,
"wbc_k_uL": 9.2,
"platelets_k_uL": 206,
"creatinine_mg_dL": 1.03,
"alt_U_L": 21
},
{
"date": "2025-03-15T00:00:00",
"hemoglobin_g_dL": 13.9,
"wbc_k_uL": 4.7,
"platelets_k_uL": 269,
"creatinine_mg_dL": 0.95,
... |
ANODE_SYNTH_2025_9966 | Non-small cell lung cancer | Squamous cell carcinoma | IVB | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 15.1,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 14
} | {
"age": 61,
"sex": "female",
"bmi": 25.6,
"smoking_pack_years": 65,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 4,
"metastatic_sites": [
"pleura",
"contralateral lung",
"liver"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2020-05-07T00:00:00",
"best_response": "Stable disease",
"radiologic_response": {
"first_ct_8wk_change_percent": -60,
"peak_response_20wk_change_percent": -40
},
"pfs_months": 30
},
... | {
"overall_survival_months": 48.1,
"censored": false
} | [
{
"date": "2020-04-10T00:00:00",
"hemoglobin_g_dL": 11.9,
"wbc_k_uL": 5.6,
"platelets_k_uL": 438,
"creatinine_mg_dL": 1.21,
"alt_U_L": 40
},
{
"date": "2020-11-03T00:00:00",
"hemoglobin_g_dL": 12.1,
"wbc_k_uL": 5.6,
"platelets_k_uL": 138,
"creatinine_mg_dL": 0.81,
... |
ANODE_SYNTH_2025_9967 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "EGFR L858R",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 4.6,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 30
} | {
"age": 83,
"sex": "female",
"bmi": 35.9,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": [
"diabetes",
"hyperlipidemia"
]
} | {
"primary_tumor_size_cm": 4.9,
"metastatic_sites": [
"bone"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2021-01-22T00:00:00",
"best_response": "Stable disease",
"radiologic_response": {
"first_ct_8wk_change_percent": -31,
"peak_response_20wk_change_percent": -78
},
"pfs_months": 30.88
},
"second_line_t... | {
"overall_survival_months": 45.6,
"censored": true
} | [
{
"date": "2021-01-04T00:00:00",
"hemoglobin_g_dL": 13.5,
"wbc_k_uL": 8.7,
"platelets_k_uL": 338,
"creatinine_mg_dL": 0.78,
"alt_U_L": 71
},
{
"date": "2021-07-21T00:00:00",
"hemoglobin_g_dL": 13.6,
"wbc_k_uL": 7.4,
"platelets_k_uL": 181,
"creatinine_mg_dL": 1.25,
... |
ANODE_SYNTH_2025_9968 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR L858R",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 5.2,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 21
} | {
"age": 59,
"sex": "female",
"bmi": 34.7,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": [
"hypertension"
]
} | {
"primary_tumor_size_cm": 7.5,
"metastatic_sites": [
"bone"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2021-07-10T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -10,
"peak_response_20wk_change_percent": -84
},
"pfs_months": 23.75
},
"second_line... | {
"overall_survival_months": 37.4,
"censored": false
} | [
{
"date": "2021-06-09T00:00:00",
"hemoglobin_g_dL": 12.2,
"wbc_k_uL": 4.8,
"platelets_k_uL": 218,
"creatinine_mg_dL": 1.13,
"alt_U_L": 74
},
{
"date": "2022-01-06T00:00:00",
"hemoglobin_g_dL": 11.2,
"wbc_k_uL": 6.7,
"platelets_k_uL": 288,
"creatinine_mg_dL": 1.01,
... |
ANODE_SYNTH_2025_9969 | Non-small cell lung cancer | Squamous cell carcinoma | IV | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 17.7,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 34
} | {
"age": 74,
"sex": "male",
"bmi": 28.8,
"smoking_pack_years": 75,
"ecog_performance_status": 1,
"comorbidities": [
"diabetes",
"hyperlipidemia"
]
} | {
"primary_tumor_size_cm": 4.1,
"metastatic_sites": [
"brain"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2020-08-28T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -40,
"peak_response_20wk_change_percent": -45
},
"pfs_months": 29.04
... | {
"overall_survival_months": 43.3,
"censored": true
} | [
{
"date": "2020-08-06T00:00:00",
"hemoglobin_g_dL": 15.1,
"wbc_k_uL": 5.3,
"platelets_k_uL": 243,
"creatinine_mg_dL": 0.71,
"alt_U_L": 26
},
{
"date": "2021-02-24T00:00:00",
"hemoglobin_g_dL": 10.7,
"wbc_k_uL": 5.5,
"platelets_k_uL": 272,
"creatinine_mg_dL": 1.45,
... |
ANODE_SYNTH_2025_9970 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 10.3,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 6
} | {
"age": 67,
"sex": "female",
"bmi": 32.6,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": [
"COPD",
"hypertension"
]
} | {
"primary_tumor_size_cm": 7.4,
"metastatic_sites": [
"brain",
"bone"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2021-01-06T00:00:00",
"best_response": "Partial response",
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"first_ct_8wk_change_percent": -54,
"peak_response_20wk_change_percent": -43
},
"pfs_months": 19.75
},
"second_line... | {
"overall_survival_months": 33.3,
"censored": false
} | [
{
"date": "2020-12-23T00:00:00",
"hemoglobin_g_dL": 14,
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"platelets_k_uL": 299,
"creatinine_mg_dL": 0.75,
"alt_U_L": 59
},
{
"date": "2021-07-05T00:00:00",
"hemoglobin_g_dL": 11.8,
"wbc_k_uL": 5.6,
"platelets_k_uL": 146,
"creatinine_mg_dL": 0.88,
"... |
ANODE_SYNTH_2025_9971 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 5.3,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 22
} | {
"age": 73,
"sex": "female",
"bmi": 26.2,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": [
"diabetes"
]
} | {
"primary_tumor_size_cm": 5.6,
"metastatic_sites": [
"pleura",
"contralateral lung"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2022-10-30T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -28,
"peak_response_20wk_change_percent": -68
},
"pfs_months": 20.8
},
"second_line_... | {
"overall_survival_months": 34.1,
"censored": false
} | [
{
"date": "2022-10-04T00:00:00",
"hemoglobin_g_dL": 15.1,
"wbc_k_uL": 5.3,
"platelets_k_uL": 335,
"creatinine_mg_dL": 0.71,
"alt_U_L": 21
},
{
"date": "2023-04-28T00:00:00",
"hemoglobin_g_dL": 11.3,
"wbc_k_uL": 5.1,
"platelets_k_uL": 226,
"creatinine_mg_dL": 0.97,
... |
ANODE_SYNTH_2025_9972 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 2.2,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 7
} | {
"age": 85,
"sex": "female",
"bmi": 22.9,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": [
"hypertension",
"COPD"
]
} | {
"primary_tumor_size_cm": 5.5,
"metastatic_sites": [
"liver"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2024-08-29T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -37,
"peak_response_20wk_change_percent": -55
},
"pfs_months": 33.22
},
"second_line... | {
"overall_survival_months": 44.6,
"censored": true
} | [
{
"date": "2024-07-23T00:00:00",
"hemoglobin_g_dL": 14.3,
"wbc_k_uL": 7.8,
"platelets_k_uL": 310,
"creatinine_mg_dL": 0.82,
"alt_U_L": 55
},
{
"date": "2025-02-25T00:00:00",
"hemoglobin_g_dL": 10.3,
"wbc_k_uL": 6.6,
"platelets_k_uL": 334,
"creatinine_mg_dL": 1.2,
... |
ANODE_SYNTH_2025_9973 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 13.4,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 19
} | {
"age": 88,
"sex": "female",
"bmi": 23.3,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": [
"hypertension",
"diabetes"
]
} | {
"primary_tumor_size_cm": 7.5,
"metastatic_sites": [
"contralateral lung",
"liver"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2025-01-05T00:00:00",
"best_response": "Stable disease",
"radiologic_response": {
"first_ct_8wk_change_percent": -51,
"peak_response_20wk_change_percent": -55
},
"pfs_months": 19.48
},
"second_line_t... | {
"overall_survival_months": 39.4,
"censored": false
} | [
{
"date": "2024-12-05T00:00:00",
"hemoglobin_g_dL": 15.3,
"wbc_k_uL": 10.2,
"platelets_k_uL": 153,
"creatinine_mg_dL": 0.94,
"alt_U_L": 61
},
{
"date": "2025-07-04T00:00:00",
"hemoglobin_g_dL": 12.7,
"wbc_k_uL": 6.3,
"platelets_k_uL": 354,
"creatinine_mg_dL": 1.09,
... |
ANODE_SYNTH_2025_9974 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 10.5,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 4
} | {
"age": 80,
"sex": "female",
"bmi": 34.9,
"smoking_pack_years": 42,
"ecog_performance_status": 0,
"comorbidities": []
} | {
"primary_tumor_size_cm": 5.1,
"metastatic_sites": [
"bone",
"contralateral lung",
"liver"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2024-12-03T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -55,
"peak_response_20wk_change_percent": -60
},
"pfs_months": 42.71
},
"second_line_th... | {
"overall_survival_months": 75.5,
"censored": true
} | [
{
"date": "2024-10-23T00:00:00",
"hemoglobin_g_dL": 12.8,
"wbc_k_uL": 7.7,
"platelets_k_uL": 249,
"creatinine_mg_dL": 0.95,
"alt_U_L": 59
},
{
"date": "2025-06-01T00:00:00",
"hemoglobin_g_dL": 13.7,
"wbc_k_uL": 6.1,
"platelets_k_uL": 286,
"creatinine_mg_dL": 0.77,
... |
ANODE_SYNTH_2025_9975 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 8.6,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 27
} | {
"age": 84,
"sex": "female",
"bmi": 33.8,
"smoking_pack_years": 12,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 5.7,
"metastatic_sites": [
"bone",
"brain",
"pleura"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2022-02-26T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -47,
"peak_response_20wk_change_percent": -62
},
"pfs_months": 19.12
},
"second_line_... | {
"overall_survival_months": 27.7,
"censored": true
} | [
{
"date": "2022-01-05T00:00:00",
"hemoglobin_g_dL": 12.7,
"wbc_k_uL": 9.8,
"platelets_k_uL": 217,
"creatinine_mg_dL": 0.76,
"alt_U_L": 38
},
{
"date": "2022-08-25T00:00:00",
"hemoglobin_g_dL": 12,
"wbc_k_uL": 8.9,
"platelets_k_uL": 300,
"creatinine_mg_dL": 0.91,
"... |
ANODE_SYNTH_2025_9976 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 12.6,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 5
} | {
"age": 70,
"sex": "female",
"bmi": 24.3,
"smoking_pack_years": 27,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 7.6,
"metastatic_sites": [
"bone",
"brain"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2021-04-07T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -36,
"peak_response_20wk_change_percent": -84
},
"pfs_months": 36.34
},
"second_line_th... | {
"overall_survival_months": 61.9,
"censored": false
} | [
{
"date": "2021-03-09T00:00:00",
"hemoglobin_g_dL": 13.9,
"wbc_k_uL": 7.1,
"platelets_k_uL": 359,
"creatinine_mg_dL": 0.83,
"alt_U_L": 28
},
{
"date": "2021-10-04T00:00:00",
"hemoglobin_g_dL": 10.8,
"wbc_k_uL": 7,
"platelets_k_uL": 144,
"creatinine_mg_dL": 1.14,
"... |
ANODE_SYNTH_2025_9977 | Non-small cell lung cancer | Squamous cell carcinoma | IV | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 16.5,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 28
} | {
"age": 74,
"sex": "female",
"bmi": 34.2,
"smoking_pack_years": 53,
"ecog_performance_status": 1,
"comorbidities": [
"hyperlipidemia",
"hypertension"
]
} | {
"primary_tumor_size_cm": 3.1,
"metastatic_sites": [
"bone",
"contralateral lung",
"pleura"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2020-10-02T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -16,
"peak_response_20wk_change_percent": -74
},
"pfs_months": 18.5
}... | {
"overall_survival_months": 27.4,
"censored": false
} | [
{
"date": "2020-09-12T00:00:00",
"hemoglobin_g_dL": 12.7,
"wbc_k_uL": 10.5,
"platelets_k_uL": 439,
"creatinine_mg_dL": 1.07,
"alt_U_L": 19
},
{
"date": "2021-03-31T00:00:00",
"hemoglobin_g_dL": 12.6,
"wbc_k_uL": 7.1,
"platelets_k_uL": 178,
"creatinine_mg_dL": 1.03,
... |
ANODE_SYNTH_2025_9978 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR L858R",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 17.9,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 10
} | {
"age": 78,
"sex": "female",
"bmi": 34.7,
"smoking_pack_years": 0,
"ecog_performance_status": 0,
"comorbidities": []
} | {
"primary_tumor_size_cm": 3.3,
"metastatic_sites": [
"pleura",
"bone"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2020-03-15T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -24,
"peak_response_20wk_change_percent": -49
},
"pfs_months": 32.89
},
"second_line... | {
"overall_survival_months": 44.7,
"censored": true
} | [
{
"date": "2020-01-09T00:00:00",
"hemoglobin_g_dL": 14.5,
"wbc_k_uL": 4.8,
"platelets_k_uL": 354,
"creatinine_mg_dL": 0.75,
"alt_U_L": 33
},
{
"date": "2020-09-11T00:00:00",
"hemoglobin_g_dL": 11.1,
"wbc_k_uL": 4.5,
"platelets_k_uL": 367,
"creatinine_mg_dL": 0.73,
... |
ANODE_SYNTH_2025_9979 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 7.6,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 19
} | {
"age": 49,
"sex": "female",
"bmi": 24.8,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": [
"diabetes",
"hypertension"
]
} | {
"primary_tumor_size_cm": 6,
"metastatic_sites": [
"brain"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2025-11-21T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -53,
"peak_response_20wk_change_percent": -41
},
"pfs_months": 16.66
},
"second_line... | {
"overall_survival_months": 29.3,
"censored": false
} | [
{
"date": "2025-10-10T00:00:00",
"hemoglobin_g_dL": 12,
"wbc_k_uL": 4.9,
"platelets_k_uL": 420,
"creatinine_mg_dL": 0.79,
"alt_U_L": 74
},
{
"date": "2026-05-20T00:00:00",
"hemoglobin_g_dL": 12.8,
"wbc_k_uL": 6.9,
"platelets_k_uL": 345,
"creatinine_mg_dL": 1.59,
"... |
ANODE_SYNTH_2025_9980 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 5.2,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 1
} | {
"age": 51,
"sex": "female",
"bmi": 19.3,
"smoking_pack_years": 76,
"ecog_performance_status": 2,
"comorbidities": [
"diabetes",
"hypertension"
]
} | {
"primary_tumor_size_cm": 6.2,
"metastatic_sites": [
"pleura",
"contralateral lung"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2024-02-02T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -27,
"peak_response_20wk_change_percent": -38
},
"pfs_months": 47.38
},
"second_line_th... | {
"overall_survival_months": 67.1,
"censored": false
} | [
{
"date": "2024-01-19T00:00:00",
"hemoglobin_g_dL": 12,
"wbc_k_uL": 5.6,
"platelets_k_uL": 334,
"creatinine_mg_dL": 0.88,
"alt_U_L": 15
},
{
"date": "2024-07-31T00:00:00",
"hemoglobin_g_dL": 12.5,
"wbc_k_uL": 7.9,
"platelets_k_uL": 259,
"creatinine_mg_dL": 0.83,
"... |
ANODE_SYNTH_2025_9981 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 2.7,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 30
} | {
"age": 49,
"sex": "male",
"bmi": 21.4,
"smoking_pack_years": 40,
"ecog_performance_status": 1,
"comorbidities": [
"hyperlipidemia"
]
} | {
"primary_tumor_size_cm": 7.7,
"metastatic_sites": [
"liver",
"contralateral lung"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2022-07-06T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -29,
"peak_response_20wk_change_percent": -41
},
"pfs_months": 4.17
},
"second_line_t... | {
"overall_survival_months": 19.5,
"censored": false
} | [
{
"date": "2022-06-01T00:00:00",
"hemoglobin_g_dL": 13.3,
"wbc_k_uL": 5,
"platelets_k_uL": 201,
"creatinine_mg_dL": 1.06,
"alt_U_L": 48
},
{
"date": "2023-01-02T00:00:00",
"hemoglobin_g_dL": 12.2,
"wbc_k_uL": 4.6,
"platelets_k_uL": 323,
"creatinine_mg_dL": 0.87,
"... |
ANODE_SYNTH_2025_9982 | Non-small cell lung cancer | Squamous cell carcinoma | IV | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 6.1,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 30
} | {
"age": 67,
"sex": "male",
"bmi": 33.5,
"smoking_pack_years": 60,
"ecog_performance_status": 1,
"comorbidities": [
"hypertension",
"diabetes"
]
} | {
"primary_tumor_size_cm": 4.1,
"metastatic_sites": [
"bone"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2021-06-10T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -24,
"peak_response_20wk_change_percent": -52
},
"pfs_months": 19.09
... | {
"overall_survival_months": 38.2,
"censored": true
} | [
{
"date": "2021-05-21T00:00:00",
"hemoglobin_g_dL": 12.1,
"wbc_k_uL": 8.8,
"platelets_k_uL": 391,
"creatinine_mg_dL": 0.83,
"alt_U_L": 33
},
{
"date": "2021-12-07T00:00:00",
"hemoglobin_g_dL": 11.8,
"wbc_k_uL": 5.1,
"platelets_k_uL": 133,
"creatinine_mg_dL": 1.31,
... |
ANODE_SYNTH_2025_9983 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 9.1,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 17
} | {
"age": 48,
"sex": "male",
"bmi": 31.6,
"smoking_pack_years": 77,
"ecog_performance_status": 1,
"comorbidities": [
"hypertension",
"hyperlipidemia"
]
} | {
"primary_tumor_size_cm": 4.9,
"metastatic_sites": [
"liver"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2023-07-29T00:00:00",
"best_response": "Stable disease",
"radiologic_response": {
"first_ct_8wk_change_percent": -23,
"peak_response_20wk_change_percent": -63
},
"pfs_months": 3.29
},
"second_line_the... | {
"overall_survival_months": 16,
"censored": false
} | [
{
"date": "2023-07-06T00:00:00",
"hemoglobin_g_dL": 11.7,
"wbc_k_uL": 8.1,
"platelets_k_uL": 253,
"creatinine_mg_dL": 0.97,
"alt_U_L": 77
},
{
"date": "2024-01-25T00:00:00",
"hemoglobin_g_dL": 11.1,
"wbc_k_uL": 7.2,
"platelets_k_uL": 327,
"creatinine_mg_dL": 1.52,
... |
ANODE_SYNTH_2025_9984 | Non-small cell lung cancer | Squamous cell carcinoma | IVB | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 8.7,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 24
} | {
"age": 82,
"sex": "female",
"bmi": 28.2,
"smoking_pack_years": 25,
"ecog_performance_status": 0,
"comorbidities": [
"hypertension",
"hyperlipidemia"
]
} | {
"primary_tumor_size_cm": 4.4,
"metastatic_sites": [
"bone",
"brain",
"contralateral lung"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2023-06-11T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -46,
"peak_response_20wk_change_percent": -68
},
"pfs_months": 20.53
... | {
"overall_survival_months": 34.7,
"censored": false
} | [
{
"date": "2023-04-08T00:00:00",
"hemoglobin_g_dL": 15.4,
"wbc_k_uL": 9.3,
"platelets_k_uL": 449,
"creatinine_mg_dL": 0.81,
"alt_U_L": 51
},
{
"date": "2023-12-08T00:00:00",
"hemoglobin_g_dL": 12.3,
"wbc_k_uL": 6.2,
"platelets_k_uL": 179,
"creatinine_mg_dL": 0.81,
... |
ANODE_SYNTH_2025_9985 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 6.7,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 19
} | {
"age": 66,
"sex": "female",
"bmi": 28.5,
"smoking_pack_years": 0,
"ecog_performance_status": 0,
"comorbidities": []
} | {
"primary_tumor_size_cm": 4.3,
"metastatic_sites": [
"liver",
"pleura"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2020-12-05T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -52,
"peak_response_20wk_change_percent": -56
},
"pfs_months": 16.39
},
"second_line... | {
"overall_survival_months": 26.2,
"censored": false
} | [
{
"date": "2020-11-14T00:00:00",
"hemoglobin_g_dL": 13.4,
"wbc_k_uL": 8.8,
"platelets_k_uL": 400,
"creatinine_mg_dL": 0.63,
"alt_U_L": 55
},
{
"date": "2021-06-03T00:00:00",
"hemoglobin_g_dL": 11.7,
"wbc_k_uL": 6.1,
"platelets_k_uL": 153,
"creatinine_mg_dL": 1.21,
... |
ANODE_SYNTH_2025_9986 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "EGFR L858R",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 15.9,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 16
} | {
"age": 82,
"sex": "female",
"bmi": 37.6,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 6.4,
"metastatic_sites": [
"pleura",
"contralateral lung"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2025-08-23T00:00:00",
"best_response": "Stable disease",
"radiologic_response": {
"first_ct_8wk_change_percent": -21,
"peak_response_20wk_change_percent": -49
},
"pfs_months": 22.54
},
"second_line_t... | {
"overall_survival_months": 44.6,
"censored": true
} | [
{
"date": "2025-08-01T00:00:00",
"hemoglobin_g_dL": 12.1,
"wbc_k_uL": 6.7,
"platelets_k_uL": 286,
"creatinine_mg_dL": 0.76,
"alt_U_L": 44
},
{
"date": "2026-02-19T00:00:00",
"hemoglobin_g_dL": 11.1,
"wbc_k_uL": 4,
"platelets_k_uL": 208,
"creatinine_mg_dL": 1.59,
"... |
ANODE_SYNTH_2025_9987 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 11.2,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 29
} | {
"age": 82,
"sex": "female",
"bmi": 31,
"smoking_pack_years": 0,
"ecog_performance_status": 2,
"comorbidities": [
"diabetes"
]
} | {
"primary_tumor_size_cm": 4.1,
"metastatic_sites": [
"bone",
"brain",
"pleura"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2025-06-26T00:00:00",
"best_response": "Stable disease",
"radiologic_response": {
"first_ct_8wk_change_percent": -56,
"peak_response_20wk_change_percent": -48
},
"pfs_months": 25.69
},
"second_line_t... | {
"overall_survival_months": 49.6,
"censored": true
} | [
{
"date": "2025-06-08T00:00:00",
"hemoglobin_g_dL": 13.2,
"wbc_k_uL": 6.9,
"platelets_k_uL": 269,
"creatinine_mg_dL": 0.66,
"alt_U_L": 65
},
{
"date": "2025-12-23T00:00:00",
"hemoglobin_g_dL": 13,
"wbc_k_uL": 5.5,
"platelets_k_uL": 175,
"creatinine_mg_dL": 1.45,
"... |
ANODE_SYNTH_2025_9988 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 10.5,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 22
} | {
"age": 83,
"sex": "female",
"bmi": 25.7,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": [
"COPD"
]
} | {
"primary_tumor_size_cm": 8.1,
"metastatic_sites": [
"liver"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2024-10-15T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -39,
"peak_response_20wk_change_percent": -58
},
"pfs_months": 23.33
},
"second_line... | {
"overall_survival_months": 42.1,
"censored": false
} | [
{
"date": "2024-09-20T00:00:00",
"hemoglobin_g_dL": 15.3,
"wbc_k_uL": 9,
"platelets_k_uL": 179,
"creatinine_mg_dL": 0.6,
"alt_U_L": 54
},
{
"date": "2025-04-13T00:00:00",
"hemoglobin_g_dL": 13.4,
"wbc_k_uL": 7.6,
"platelets_k_uL": 284,
"creatinine_mg_dL": 1.13,
"a... |
ANODE_SYNTH_2025_9989 | Non-small cell lung cancer | Squamous cell carcinoma | IV | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 3.2,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 3
} | {
"age": 74,
"sex": "female",
"bmi": 28.3,
"smoking_pack_years": 48,
"ecog_performance_status": 0,
"comorbidities": [
"hyperlipidemia",
"COPD"
]
} | {
"primary_tumor_size_cm": 4.5,
"metastatic_sites": [
"pleura",
"contralateral lung"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2024-02-25T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -52,
"peak_response_20wk_change_percent": -82
},
"pfs_months": 12.12
... | {
"overall_survival_months": 22.4,
"censored": true
} | [
{
"date": "2024-01-01T00:00:00",
"hemoglobin_g_dL": 13,
"wbc_k_uL": 6.5,
"platelets_k_uL": 346,
"creatinine_mg_dL": 0.83,
"alt_U_L": 48
},
{
"date": "2024-08-23T00:00:00",
"hemoglobin_g_dL": 11.3,
"wbc_k_uL": 5.7,
"platelets_k_uL": 236,
"creatinine_mg_dL": 1.09,
"... |
ANODE_SYNTH_2025_9990 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "NTRK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 14.2,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 23
} | {
"age": 62,
"sex": "female",
"bmi": 20.5,
"smoking_pack_years": 68,
"ecog_performance_status": 2,
"comorbidities": [
"hyperlipidemia",
"COPD"
]
} | {
"primary_tumor_size_cm": 7.3,
"metastatic_sites": [
"bone",
"liver",
"pleura"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "larotrectinib 100 mg BID",
"start_date": "2020-12-31T00:00:00",
"best_response": "Stable disease",
"radiologic_response": {
"first_ct_8wk_change_percent": -45,
"peak_response_20wk_change_percent": -63
},
"pfs_months": 37.88
},
"second_line_... | {
"overall_survival_months": 56.5,
"censored": true
} | [
{
"date": "2020-12-12T00:00:00",
"hemoglobin_g_dL": 12.4,
"wbc_k_uL": 5.5,
"platelets_k_uL": 337,
"creatinine_mg_dL": 1.17,
"alt_U_L": 71
},
{
"date": "2021-06-29T00:00:00",
"hemoglobin_g_dL": 12,
"wbc_k_uL": 4.9,
"platelets_k_uL": 182,
"creatinine_mg_dL": 0.72,
"... |
ANODE_SYNTH_2025_9991 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 12.4,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 17
} | {
"age": 84,
"sex": "male",
"bmi": 31.3,
"smoking_pack_years": 44,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 4.4,
"metastatic_sites": [
"bone"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2025-02-13T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -41,
"peak_response_20wk_change_percent": -52
},
"pfs_months": 36.53
},
"second_line_th... | {
"overall_survival_months": 63.3,
"censored": true
} | [
{
"date": "2025-01-26T00:00:00",
"hemoglobin_g_dL": 14,
"wbc_k_uL": 6.3,
"platelets_k_uL": 345,
"creatinine_mg_dL": 0.93,
"alt_U_L": 41
},
{
"date": "2025-08-12T00:00:00",
"hemoglobin_g_dL": 13,
"wbc_k_uL": 6.1,
"platelets_k_uL": 272,
"creatinine_mg_dL": 1.09,
"al... |
ANODE_SYNTH_2025_9992 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 17.7,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 20
} | {
"age": 72,
"sex": "female",
"bmi": 28.5,
"smoking_pack_years": 46,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 7,
"metastatic_sites": [
"brain",
"pleura",
"liver"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2025-09-03T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -46,
"peak_response_20wk_change_percent": -38
},
"pfs_months": 46.59
},
"second_line_th... | {
"overall_survival_months": 75.5,
"censored": true
} | [
{
"date": "2025-08-13T00:00:00",
"hemoglobin_g_dL": 11.8,
"wbc_k_uL": 9.9,
"platelets_k_uL": 230,
"creatinine_mg_dL": 0.82,
"alt_U_L": 22
},
{
"date": "2026-03-02T00:00:00",
"hemoglobin_g_dL": 11.5,
"wbc_k_uL": 8.1,
"platelets_k_uL": 197,
"creatinine_mg_dL": 1.24,
... |
ANODE_SYNTH_2025_9993 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "EGFR exon 19 deletion",
"t790m_resistance": false,
"tumor_mutational_burden_mut_Mb": 8.7,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 24
} | {
"age": 77,
"sex": "female",
"bmi": 23,
"smoking_pack_years": 0,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 7.9,
"metastatic_sites": [
"liver"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "osimertinib 80 mg daily",
"start_date": "2023-02-23T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -51,
"peak_response_20wk_change_percent": -67
},
"pfs_months": 21.39
},
"second_line... | {
"overall_survival_months": 27.9,
"censored": false
} | [
{
"date": "2023-01-21T00:00:00",
"hemoglobin_g_dL": 13.3,
"wbc_k_uL": 4.6,
"platelets_k_uL": 408,
"creatinine_mg_dL": 0.6,
"alt_U_L": 59
},
{
"date": "2023-08-22T00:00:00",
"hemoglobin_g_dL": 11.2,
"wbc_k_uL": 6.3,
"platelets_k_uL": 252,
"creatinine_mg_dL": 0.72,
... |
ANODE_SYNTH_2025_9994 | Non-small cell lung cancer | Squamous cell carcinoma | IV | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 2.4,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 11
} | {
"age": 76,
"sex": "male",
"bmi": 35.7,
"smoking_pack_years": 77,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 7.1,
"metastatic_sites": [
"brain",
"contralateral lung",
"liver"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2023-03-06T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -21,
"peak_response_20wk_change_percent": -43
},
"pfs_months": 19.88
... | {
"overall_survival_months": 35.3,
"censored": false
} | [
{
"date": "2023-01-23T00:00:00",
"hemoglobin_g_dL": 11.6,
"wbc_k_uL": 8.6,
"platelets_k_uL": 285,
"creatinine_mg_dL": 0.79,
"alt_U_L": 24
},
{
"date": "2023-09-02T00:00:00",
"hemoglobin_g_dL": 13.7,
"wbc_k_uL": 8.1,
"platelets_k_uL": 293,
"creatinine_mg_dL": 1.11,
... |
ANODE_SYNTH_2025_9995 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 4.3,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 34
} | {
"age": 75,
"sex": "female",
"bmi": 29.4,
"smoking_pack_years": 25,
"ecog_performance_status": 1,
"comorbidities": [
"diabetes"
]
} | {
"primary_tumor_size_cm": 7.5,
"metastatic_sites": [
"bone"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT + brain MRI confirmed extracranial metastases; asymptomatic brain metastases present."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2023-03-08T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -35,
"peak_response_20wk_change_percent": -70
},
"pfs_months": 43.04
},
"second_line_th... | {
"overall_survival_months": 67.6,
"censored": false
} | [
{
"date": "2022-12-28T00:00:00",
"hemoglobin_g_dL": 14,
"wbc_k_uL": 6.8,
"platelets_k_uL": 168,
"creatinine_mg_dL": 0.69,
"alt_U_L": 36
},
{
"date": "2023-09-04T00:00:00",
"hemoglobin_g_dL": 13.9,
"wbc_k_uL": 8.7,
"platelets_k_uL": 368,
"creatinine_mg_dL": 1.15,
"... |
ANODE_SYNTH_2025_9996 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 16.3,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 11
} | {
"age": 69,
"sex": "female",
"bmi": 19.8,
"smoking_pack_years": 31,
"ecog_performance_status": 1,
"comorbidities": [
"hyperlipidemia",
"diabetes"
]
} | {
"primary_tumor_size_cm": 4.5,
"metastatic_sites": [
"contralateral lung",
"liver"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2026-01-08T00:00:00",
"best_response": "Stable disease",
"radiologic_response": {
"first_ct_8wk_change_percent": -55,
"peak_response_20wk_change_percent": -74
},
"pfs_months": 7.39
},
"second_line_the... | {
"overall_survival_months": 12.8,
"censored": false
} | [
{
"date": "2025-12-04T00:00:00",
"hemoglobin_g_dL": 14.5,
"wbc_k_uL": 9.2,
"platelets_k_uL": 191,
"creatinine_mg_dL": 0.82,
"alt_U_L": 35
},
{
"date": "2026-07-07T00:00:00",
"hemoglobin_g_dL": 13.8,
"wbc_k_uL": 7.8,
"platelets_k_uL": 170,
"creatinine_mg_dL": 0.88,
... |
ANODE_SYNTH_2025_9997 | Non-small cell lung cancer | Adenocarcinoma | IV | {
"driver_mutation": "ALK fusion",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 9,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 14
} | {
"age": 67,
"sex": "male",
"bmi": 28.7,
"smoking_pack_years": 11,
"ecog_performance_status": 0,
"comorbidities": []
} | {
"primary_tumor_size_cm": 7.3,
"metastatic_sites": [
"bone",
"brain",
"pleura"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "alectinib 600 mg BID",
"start_date": "2023-08-23T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -17,
"peak_response_20wk_change_percent": -38
},
"pfs_months": 31.7
},
"second_line_the... | {
"overall_survival_months": 56.2,
"censored": false
} | [
{
"date": "2023-07-28T00:00:00",
"hemoglobin_g_dL": 11.8,
"wbc_k_uL": 5.6,
"platelets_k_uL": 249,
"creatinine_mg_dL": 0.86,
"alt_U_L": 10
},
{
"date": "2024-02-19T00:00:00",
"hemoglobin_g_dL": 11.6,
"wbc_k_uL": 6.9,
"platelets_k_uL": 281,
"creatinine_mg_dL": 0.87,
... |
ANODE_SYNTH_2025_9998 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 8.2,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 12
} | {
"age": 68,
"sex": "male",
"bmi": 20.9,
"smoking_pack_years": 11,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 3.2,
"metastatic_sites": [
"contralateral lung",
"pleura"
],
"brain_metastases_present": true,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2025-12-24T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -24,
"peak_response_20wk_change_percent": -67
},
"pfs_months": 2.96
},
"second_line_t... | {
"overall_survival_months": 7.5,
"censored": false
} | [
{
"date": "2025-11-27T00:00:00",
"hemoglobin_g_dL": 14.8,
"wbc_k_uL": 7.1,
"platelets_k_uL": 448,
"creatinine_mg_dL": 1.18,
"alt_U_L": 47
},
{
"date": "2026-06-22T00:00:00",
"hemoglobin_g_dL": 10.8,
"wbc_k_uL": 6.4,
"platelets_k_uL": 373,
"creatinine_mg_dL": 0.89,
... |
ANODE_SYNTH_2025_9999 | Non-small cell lung cancer | Squamous cell carcinoma | IV | {
"driver_mutation": "None (PD-L1 high)",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 16.7,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 16
} | {
"age": 73,
"sex": "female",
"bmi": 31.8,
"smoking_pack_years": 65,
"ecog_performance_status": 1,
"comorbidities": [
"hyperlipidemia",
"COPD"
]
} | {
"primary_tumor_size_cm": 3.9,
"metastatic_sites": [
"pleura"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "carboplatin + pemetrexed + pembrolizumab",
"start_date": "2023-03-08T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -25,
"peak_response_20wk_change_percent": -47
},
"pfs_months": 22.97
... | {
"overall_survival_months": 28.1,
"censored": false
} | [
{
"date": "2023-01-06T00:00:00",
"hemoglobin_g_dL": 12.4,
"wbc_k_uL": 4.6,
"platelets_k_uL": 394,
"creatinine_mg_dL": 1.25,
"alt_U_L": 45
},
{
"date": "2023-09-04T00:00:00",
"hemoglobin_g_dL": 14,
"wbc_k_uL": 6.8,
"platelets_k_uL": 204,
"creatinine_mg_dL": 0.87,
"... |
ANODE_SYNTH_2025_10000 | Non-small cell lung cancer | Adenocarcinoma | IVB | {
"driver_mutation": "KRAS G12C",
"t790m_resistance": null,
"tumor_mutational_burden_mut_Mb": 14.2,
"microsatellite_status": "MSS",
"pd_l1_tps_percent": 22
} | {
"age": 72,
"sex": "female",
"bmi": 36,
"smoking_pack_years": 71,
"ecog_performance_status": 1,
"comorbidities": []
} | {
"primary_tumor_size_cm": 3.5,
"metastatic_sites": [
"pleura",
"contralateral lung"
],
"brain_metastases_present": false,
"radiology_summary": "PET-CT showed hypermetabolic primary mass with metastatic deposits; no intracranial disease."
} | {
"first_line_therapy": {
"regimen": "sotorasib 960 mg daily",
"start_date": "2025-10-29T00:00:00",
"best_response": "Partial response",
"radiologic_response": {
"first_ct_8wk_change_percent": -16,
"peak_response_20wk_change_percent": -78
},
"pfs_months": 22.14
},
"second_line_... | {
"overall_survival_months": 35.3,
"censored": false
} | [
{
"date": "2025-09-04T00:00:00",
"hemoglobin_g_dL": 12.2,
"wbc_k_uL": 7.3,
"platelets_k_uL": 407,
"creatinine_mg_dL": 1.07,
"alt_U_L": 12
},
{
"date": "2026-04-27T00:00:00",
"hemoglobin_g_dL": 10.7,
"wbc_k_uL": 8.6,
"platelets_k_uL": 140,
"creatinine_mg_dL": 1.06,
... |
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