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Upload EHR_Genomics_AnodeAI_sample.json

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+ {
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+ "patient_demographics": {
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+ "patient_id": "ANODE-ONC-75270",
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+ "age": 80,
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+ "gender": "Female",
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+ "ethnicity": "Hispanic"
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+ },
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+ "clinical_oncology_profile": {
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+ "primary_diagnosis": "Infiltrating Ductal Carcinoma (Breast Cancer)",
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+ "stage_at_presentation": "T2N0M0 (Stage IIA)",
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+ "histological_grade": "Grade 1 (Well Differentiated)",
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+ "biomarker_status": {
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+ "ER": "Positive (60%)",
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+ "PR": "Positive (75%)",
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+ "HER2": "Negative (1+ by IHC)"
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+ }
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+ },
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+ "genomic_sequencing_data": {
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+ "sequencing_type": "Targeted Next-Generation Sequencing (NGS)",
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+ "somatic_variants_detected": [
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+ {
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+ "gene": "PIK3CA",
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+ "alteration": "p.E545K",
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+ "variant_allele_frequency_vaf": 0.46
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+ },
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+ {
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+ "gene": "ESR1",
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+ "alteration": "p.D538G",
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+ "variant_allele_frequency_vaf": 0.23
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+ },
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+ {
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+ "gene": "TP53",
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+ "alteration": "p.R273H",
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+ "variant_allele_frequency_vaf": 0.42
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+ }
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+ ]
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+ },
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+ "longitudinal_treatment_ehr": {
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+ "line_of_therapy": 1,
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+ "regimen_administered": "Palbociclib + Letrozole",
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+ "cycles_completed": 7,
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+ "adverse_events_ctcae_v5": [
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+ {
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+ "toxicity": "Fatigue",
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+ "grade": 3,
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+ "action_taken": "Supportive care"
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+ }
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+ ],
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+ "treatment_response_recist_1_1": "Complete Response (CR)",
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+ "progression_free_survival_months": 50.0
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+ }
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+ }