Upload EHR_Genomics_AnodeAI_sample.json
Browse files
EHR_Genomics_AnodeAI_sample.json
ADDED
|
@@ -0,0 +1,52 @@
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 1 |
+
{
|
| 2 |
+
"patient_demographics": {
|
| 3 |
+
"patient_id": "ANODE-ONC-75270",
|
| 4 |
+
"age": 80,
|
| 5 |
+
"gender": "Female",
|
| 6 |
+
"ethnicity": "Hispanic"
|
| 7 |
+
},
|
| 8 |
+
"clinical_oncology_profile": {
|
| 9 |
+
"primary_diagnosis": "Infiltrating Ductal Carcinoma (Breast Cancer)",
|
| 10 |
+
"stage_at_presentation": "T2N0M0 (Stage IIA)",
|
| 11 |
+
"histological_grade": "Grade 1 (Well Differentiated)",
|
| 12 |
+
"biomarker_status": {
|
| 13 |
+
"ER": "Positive (60%)",
|
| 14 |
+
"PR": "Positive (75%)",
|
| 15 |
+
"HER2": "Negative (1+ by IHC)"
|
| 16 |
+
}
|
| 17 |
+
},
|
| 18 |
+
"genomic_sequencing_data": {
|
| 19 |
+
"sequencing_type": "Targeted Next-Generation Sequencing (NGS)",
|
| 20 |
+
"somatic_variants_detected": [
|
| 21 |
+
{
|
| 22 |
+
"gene": "PIK3CA",
|
| 23 |
+
"alteration": "p.E545K",
|
| 24 |
+
"variant_allele_frequency_vaf": 0.46
|
| 25 |
+
},
|
| 26 |
+
{
|
| 27 |
+
"gene": "ESR1",
|
| 28 |
+
"alteration": "p.D538G",
|
| 29 |
+
"variant_allele_frequency_vaf": 0.23
|
| 30 |
+
},
|
| 31 |
+
{
|
| 32 |
+
"gene": "TP53",
|
| 33 |
+
"alteration": "p.R273H",
|
| 34 |
+
"variant_allele_frequency_vaf": 0.42
|
| 35 |
+
}
|
| 36 |
+
]
|
| 37 |
+
},
|
| 38 |
+
"longitudinal_treatment_ehr": {
|
| 39 |
+
"line_of_therapy": 1,
|
| 40 |
+
"regimen_administered": "Palbociclib + Letrozole",
|
| 41 |
+
"cycles_completed": 7,
|
| 42 |
+
"adverse_events_ctcae_v5": [
|
| 43 |
+
{
|
| 44 |
+
"toxicity": "Fatigue",
|
| 45 |
+
"grade": 3,
|
| 46 |
+
"action_taken": "Supportive care"
|
| 47 |
+
}
|
| 48 |
+
],
|
| 49 |
+
"treatment_response_recist_1_1": "Complete Response (CR)",
|
| 50 |
+
"progression_free_survival_months": 50.0
|
| 51 |
+
}
|
| 52 |
+
}
|