Update README.md

README.md

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----
-license: mit
----
+---
+license: mit
+language:
+- en
+pretty_name: ABX-CS-008 Pediatric Dosing Effectiveness Decay
+tags:
+- antibiotics
+- clinical
+- pediatrics
+- dosing
+- weight-based
+- pk-pd
+- tabular
+task_categories:
+- tabular-classification
+size_categories:
+- n<1k
+---
+
+ABX-CS-008 Pediatric Dosing Effectiveness Decay
+
+Purpose
+
+Detect early pediatric dosing decoupling when weight-based dosing no longer predicts exposure and response.
+
+Core pattern
+
+- severity_index high
+- dose_mg_per_kg_per_day is near expected
+- pediatric_coherence_index drops
+- exposure_shortfall_vs_expected stays high
+- efficacy_shortfall_vs_expected stays high
+- symptom_nonresponse_vs_expected stays high
+- later_dose_escalation_or_abx_change_or_prolonged_admission_flag appears
+
+Files
+
+- data/train.csv
+- data/test.csv
+- scorer.py
+
+Schema
+
+Each row is one timepoint in a within series pediatric antibiotic course.
+
+Required columns
+
+- row_id
+- series_id
+- day
+- host_model
+- age_years
+- weight_kg
+- abx_drug
+- dose_mg_per_kg_per_day
+- expected_dose_mg_per_kg_per_day
+- dose_deviation_mg_kg
+- exposure_index
+- expected_exposure_index
+- exposure_shortfall_vs_expected
+- efficacy_index
+- expected_efficacy_index
+- efficacy_shortfall_vs_expected
+- symptom_score
+- expected_symptom_score
+- symptom_nonresponse_vs_expected
+- severity_index
+- pediatric_coherence_index
+- later_dose_escalation_or_abx_change_or_prolonged_admission_flag
+- assay_method
+- source_type
+- pediatric_dosing_effectiveness_decay_signal
+- earliest_pediatric_dosing_effectiveness_decay
+
+Labels
+
+- pediatric_dosing_effectiveness_decay_signal
+  - 1 for rows at or after first confirmed decay onset
+
+- earliest_pediatric_dosing_effectiveness_decay
+  - 1 only for the first onset row in that series
+
+Scorer logic in v1
+
+- require severity_index at least 0.80
+- require actual dose at least 90 percent of expected dose
+- candidate onset point
+  - pediatric_coherence_index at most 0.40
+  - exposure_shortfall_vs_expected at least 0.25
+  - efficacy_shortfall_vs_expected at least 0.20
+  - symptom_nonresponse_vs_expected at least 2.0
+  - for two consecutive points
+  - ignore one point exposure shortfall spike then recovery
+- confirmation
+  - later_dose_escalation_or_abx_change_or_prolonged_admission_flag equals 1 later in series
+
+Evaluation
+
+Run
+
+- python scorer.py --path data/test.csv