id stringclasses 6
values | drug_name stringclasses 6
values | condition_context stringclasses 4
values | baseline_fragility_profile stringclasses 6
values | on_drug_fragility_profile stringclasses 6
values | post_drug_fragility_profile stringclasses 4
values | buffering_mechanism_hypothesis stringclasses 6
values | buffered_fragility_axes stringclasses 6
values | primary_buffering_mechanism stringclasses 6
values | secondary_effects stringclasses 6
values | durability_of_buffering stringclasses 3
values | tradeoff_risks stringclasses 2
values | net_system_integrity_effect stringclasses 3
values | notes stringclasses 6
values | constraints stringclasses 1
value | gold_checklist stringclasses 1
value |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FBMM-001 | metformin | multi-morbid | High glucose variance; low mitochondrial reserve | Variance down; exercise tolerance up | Partial persistence | AMPK activation improves energy handling | metabolic; mitochondrial | mitochondrial efficiency | GI discomfort early | Medium | Low | Positive | Classic resilience mechanism | Under 260 words. | axes+mechanism+durability |
FBMM-002 | rapamycin | aging | Inflammaging; slow recovery | Inflammatory markers down; recovery faster | Returns baseline | mTOR modulation reduces chronic inflammatory tone | immune; metabolic | inflammaging reduction | Infection susceptibility | Low | Medium | Mixed | Dose sensitive buffering | Under 260 words. | axes+mechanism+durability |
FBMM-003 | exercise_mimetic | aging | Low stress tolerance; fatigue | Tolerance improves; HRV up | Persists | Mitochondrial biogenesis signal | mitochondrial; autonomic | energy reserve expansion | Transient fatigue | High | Low | Positive | Durable capacity gain | Under 260 words. | axes+mechanism+durability |
FBMM-004 | SSRI | depression | Autonomic rigidity; sleep fragility | Flexibility improves; sleep stable | Reverts baseline | Neural plasticity increase | neural; autonomic | network plasticity | Emotional blunting | Low | Low | Neutral | Resilience tied to dosing | Under 260 words. | axes+mechanism+durability |
FBMM-005 | beta_blocker | cardiac | Stress-induced arrhythmia; low tolerance | Arrhythmia suppressed; fatigue | Returns baseline | Autonomic dampening | autonomic | sympathetic suppression | Reduced exercise capacity | Low | Medium | Mixed | Control without buffering | Under 260 words. | axes+mechanism+durability |
FBMM-006 | senolytic | aging | High senescent burden; slow recovery | Markers down; stress response improves | Partial persistence | Senescent cell clearance | immune; tissue repair | damage load reduction | Transient inflammation | Medium | Medium | Positive | System-level reset effect | Under 260 words. | axes+mechanism+durability |
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