---
license: mit
language:
- en

tags:
- clinical-trials
- protocol-deviation
- data-quality
- adjudication
- staffing
- missing-data
- quad-coupling
- reasoning
- trial-integrity

task_categories:
- tabular-classification

pretty_name: Clinical Quad – Protocol Deviation × Staffing Drift × Adjudication Variance × Missingness Bias
---

# Clinical Quad: Signal Detection Drift × AE Coding Variance × Unblinding Risk × DSMB Decision Delay

This dataset targets safety governance collapse.

Signals weaken or shift.  
AE coding diverges across sites.  
Unblinding pressure rises.  
The DSMB response slows.

The quad can turn a manageable safety issue into a governance failure.

## Variables

- signal_detection_drift (low | medium | high)
- ae_coding_variance (low | medium | high)
- unblinding_risk (low | medium | high)
- dsmb_decision_delay (low | medium | high)

## Labels

- coherent
- tradeoff
- collapse_risk

## Collapse rule

All four dimensions high.

## Why it matters

You want models to spot when “we are monitoring safety” is no longer true in practice.