id,drug_name,condition_context,pre_drug_state_summary,on_drug_state_summary,post_drug_state_summary,observation_window,drift_vector,affected_system_axes,temporal_drift_profile,reversibility_flag,net_coherence_delta,notes,constraints,gold_checklist
SDFE-001,SSRI,depression,"Sleep fragmented; HRV low; appetite variable","Sleep latency improves; HRV flat; GI motility slows","Sleep regresses; GI normalizes","9 months","Neural calming + GI slowing","neural; gastrointestinal","Gradual onset; slow offset","partial","Neutral","Neural gain with GI cost","Under 220 words.","vector+axes+profile"
SDFE-002,metformin,type2_diabetes,"Glucose high variance; weight rising","Glucose variance down; appetite reduced; GI upset","Glucose stable; GI improves","12 months","Metabolic stabilization + GI perturbation","metabolic; gastrointestinal","Early GI hit then adaptation","yes","Positive","Classic metabolic drift","Under 220 words.","vector+axes+profile"
SDFE-003,steroid,autoimmune_flare,"Pain high; fatigue; labs variable","Pain down; sleep worse; glucose up","Rebound pain; fatigue persists","6 months","Inflammation suppression + metabolic stress","immune; metabolic; sleep","Fast onset; rebound offset","no","Negative","Suppression without repair","Under 220 words.","vector+axes+profile"
SDFE-004,beta_blocker,arrhythmia,"HR variability high; anxiety spikes","HR steadier; fatigue up","Fatigue resolves; HR variability returns","8 months","Autonomic damping","autonomic; cardiovascular","Immediate onset; clean offset","yes","Mixed","Control with energy cost","Under 220 words.","vector+axes+profile"
SDFE-005,GLP1,obesity,"Weight gain; appetite dysregulated","Weight loss; nausea; low intake","Weight stable; nausea gone","10 months","Appetite suppression + intake restructuring","metabolic; neural","Stepwise drift then plateau","yes","Positive","Strong appetite axis push","Under 220 words.","vector+axes+profile"
SDFE-006,benzodiazepine,anxiety,"Hyperarousal; insomnia","Anxiety low; sedation high","Rebound anxiety; sleep worse","7 months","Arousal suppression + dependence drift","neural; sleep","Immediate onset; rebound offset","no","Negative","Fragility fingerprint","Under 220 words.","vector+axes+profile"