title: Bone regeneration on the background of the local impact of insulin-like growth factor-1 (experimental study)
abstract: The problem of the optimization and stimulation of bone regeneration in orthopedics and traumatology is particularly relevant in the presence of large size and complex bone defects. Among the numerous growth factors insulin-like growth factor-1 (IGF-1) is one of the most important hormonal mediators and regulators of growth hormone. IGF-1 may act on bone tissue both systemically and locally. IGF-1 regulates the growth, development and differentiation of cells and tissues and in particular of bon
journal: ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS