title: Adverse reactions of high-osmolar and low-osmolar radiographic contrast media in clinical practice
abstract: Introduction . Adverse drug reactions (ADR) to administration of radiographic contrast media (RCM) are observed in 10–20 % of patients. Individual tolerability of drugs is affected by RCM properties (ionicity, osmolarity). Aim . Evaluation of ADR in patients during diagnostic studies using high- and low-osmolar RCM. Methods . Analysis of 52 reports of adverse reactions to RCM registered in medical organizations of Voronezh region in 2014–2021 was performed. Group 1 included 21 patients with ADR 
journal: Kachestvennaya Klinicheskaya Praktika = Good Clinical Practice