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|dc.contributor.author||DEVIDAS, NAYAK AKSHATA||-|
|dc.creator||DEVIDAS, NAYAK AKSHATA||-|
|dc.description.abstract||Part I. Synthesis, Anti-Renal Fibrosis Activity, and Binding Affinity of Truncated 2-Hexynyl-N6-substituted-(N)-methano-carbanucleosides as A3 Adenosine Receptor Ligands Extracellular adenosine acts as a signaling molecule and regulates many physiological functions by mediating cell signaling through binding to four subtypes (A1, A2A, A2B, and A3) of adenosine receptors (ARs) in our body. On the basis of the structure of adenosine, extensive modifications on the N6 and/or 4′-CH2OH of adenosine have been explored to achieve subtype selectivity, among which a truncated 2-chloro-N6-(3-iodobenzyl)-thioadenosine (Ki = 4.16 nM) was discovered as a potent and species-independent A3AR antagonist. Further, truncated N6-substituted-4'-oxo- and 4'-thioadenosine derivatives with C2 or C8 substitution was observed to be dual acting A2A and A3 adenosine receptor ligands with potent anti-inflammatory activity. In order to examine if truncated N6-substituted-(N)-methanocarbaadenosine derivatives having 2-hexynyl substituent show the activity similar to that of the corresponding 4'-thioadenosine derivatives, the former was synthesized starting from D-ribose. The functionalization at the C2-position of 6-chloropurine derivatives was achieved via lithiation mediated stannyl transfer and copper-or palladium catalyzed coupling reactions. The N6-metylamino derivative (Ki = 4.19 nM) was discovered as highly selective low efficacy partial antagonist of A3AR. It was found that high binding affinity was retained in A3AR but not in A2AAR. All synthesized compounds were screened for renoprotective effects in human TGF-β1-stimulated mProx tubular cells, a kidney fibrosis model. Most compounds strongly inhibited TGF-β1-induced collagen I upregulation, and their A3AR binding affinities were proportional to anti-fibrotic effects; N6-methylamino derivative was most potent (IC50 = 0.83 μM), indicating its potential as a good therapeutic candidate for treating renal fibrosis as well. Part II. Synthesis and Biological Evaluation of 2'-β-Substituted-fluoroneplanocin A Analogues as Antiviral and Anticancer Agents Aristeromycin and neplanocin A are representatives of carbocyclic nucleosides which showed significant broad-spectrum antiviral and antitumor activity. However due to their cytotoxicity to host cells, they could only serve as lead compounds for further development of medicinally potent analogues. From the systemic structure-activity relationship study, fluoroneplanocin A and fluorocyclopentenyl-cytosine have emerged as promising antiviral and antitumor agents. Because modification at C-2′ position have been recognized as important means to further enhance the efficacy, based on these findings, 2'β-substituted fluoroneplanocin A analogs were synthesized and evaluated for their antiviral and anticancer activities against several viruses and tumor cell lines. Selective protection of allylic hydroxyl group, DAST fluorination and Mitsunobu condensation were employed as key steps to obtain the target nucleosides. However, none of the compounds showed any significant activities which might be due to the lack of 2'-hydroxyl group.;Part I. Synthesis, Anti-Renal Fibrosis Activity, and Binding Affinity of Truncated 2-Hexynyl-N6-substituted-(N)-methanocarbanucleosides as A3 Adenosine Receptor Ligands 세포 외 아데노신 은 신체 내 아데노신 수용체 (A1, A2A, A2B, A3)에 결합함으로써 다양한 생리활성을 조절한다. 아데노신 분자 구조에 근거해서, 아데노신 구조에 근거하여 종간-독립적이고 효과적인 A3 아데노신 수용체 길항제를 발견하기 위해서, 아데노신의 N6와 4’-CH2OH를 다른 group으로 치환하여 다른 종류의 아데노신 수용체에 대해서 선택적인 truncated 2-chloro-N6-(3-iodobenzyl)-thioadenosine (Ki = 4.16 nM)를 합성하였다. C2과 C8 위치에 치환체를 가진 truncated N6-substituted-4'-oxo- 과 4'-thioadenosine 유도체는 A2A와 A3 아데노신 수용체에 모두 결합하며 항염증 효과를 나타내었다. 2-hexyl 치환체를 가진 truncated N6-substituted-(N)-methanocarbaadenosine 유도체가 4’-thioadenosine과 비슷한 정도의 활성을 보이는지 확인하기 위해서 그 유도체를 D-ribose로부터 합성하였다. N6-metylamino derivative (Ki = 4.19 nM)는 높은 선택성의 A3 아데노신 수용체 부분 길항제로 밝혀졌다. Lithiation을 경유한 stannyl 이동 반응과 구리/팔라듐 촉매 커플링 반응을 통하여 6-chloropurine의 2번과 6번에 치환체를 도입하였다. 이것은 A3 아데노신 수용체에 대해서는 높은 결합 친화력이 유지가 되었으나 A2A 아데노신 수용체에 대해서는 그렇지 않았다. 모든 합성된 물질은 사람 신장 섬유증 모델의 TGF-β1-stimulated mProx tubular cells 에서 보호효과를 보았다. 대부분의 물질들은 TGF-β1-induced collagen I 의 upregulation을 억제하였다; N6-methylamino 유도체가 가장 효과적 이였고, 이 물질은 신장 섬유증의 치료에 좋은 후보물질이 될 것으로 예상한된다. Part II. Synthesis and Biological Evaluation of 2'-β-Substituted-fluoroneplanocin A Analogues as Anti viral and Anticancer Agents Aristeromycin과 neplanocin A는 대표적인 carbocyclic nucleoside로 광범위 항바이러스, 항암 효과를 가지지만, 숙주 세포에 대한 세포독성 때문에 효과적인 치료제로 개발하는데 한계가 있다. 구조-활성 관계 연구를 통해 fluoroneplanocin A와 fluorocyclopentenyl-cytosine은 유력한 항바러스제, 항암제가 될 가능성이 있음이 밝혀졌다. C-2’ 번 위치를 변경하는 것이 효과를 증대시키는데 중요하기 때문에, 이 사실에 근거하여, 2′β를 치환한 fluoroneplanocin A 유도체를 합성하고, 항바이러스와 항암 효과를 평가했다. 이 타겟 물질을 얻는데 중요한 반응으로 allylic hydroxyl group의 선택적인 protection과 DAST fluorination, Mitsunobu condensation이 수행되었다. 그러나 어떤 물질도 활성을 보이지 않았는데, 아마도 2’-hydroxyl group이 없었기 때문으로 예상된다.||-|
|dc.description.tableofcontents||Introduction : Recent Advances in the Synthesis of the Carbocyclic Nucleosides via Ring-Closing Metathesis(RCM) 1 I. Introduction 2 II. Ring-Closing Metathesis (RCM) in Nucleoside Chemistry 6 A. Olefin Metathesis and its Historical Perspectives 6 B. Synthesis of Carbocyclic Nucleosides (Five-Membered Ring Systems) 8 1. Synthesis of Carbocyclic Nucleosides via RCM Using Carbohydrate Templates 9 2. Syntheses Involving Unconventional Approaches with RCM as a Key step 30 III. Conclusions 38 IV. References 39 Part I. Synthesis, Anti-Renal Fibrosis Activity, and Binding Affinity of Truncated 2-Hexynyl-N6-substituted-(N)-methanocarbanucleosides as A3 Adenosine Receptor Ligands 46 I. Introduction 47 II. Results and Discussions 53 A. Chemistry 53 B. Binding Affinity 58 C. Renoprotective Effects 63 D. Molecular Docking Study 64 III. Conclusion 67 IV. Experimental Section 69 V. References 88 Part II. Synthesis and Biological Evaluation of 2'-β- Substituted-fluoroneplanocin A Analogues as Antiviral and Anticancer Agents 98 I. Introduction 99 A. Viruses, Human Diseases and Remedies 99 B. Carbocyclic Nucleoside Analogs as Antiviral and Anticancer Agents 101 C. Targets of Action of Carbocyclic Nucleoside Analogs 104 1. S-Adenosylhomocysteine Hydrolase (SAH Hydrolase) 105 2. CTP Synthetase 106 D. Effect of Fluorine Substituents 108 E. Rationale for Target Nucleosides 108 II. Results and Discussions 111 A. Chemistry 111 1. Synthesis of Glycosyl Donor 111 2. Synthesis of 2'-β-Substituted Purine Nucleosides 122 3. Synthesis of 2'-β-Substituted Pyrimidine Nucleosides 124 B. Biological Activity 126 III. Conclusion 129 IV. Experimental Section 130 V. References 155 Abstract in Korean 163 Acknowledgement 166||-|
|dc.title||Synthesis and Biological Evaluation of Novel Carbocyclic Nucleosides||-|
|dc.format.page||xix, 167 p.||-|
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text:
After a rather sea-sick experience trying to listen to Laurent Korcia slip and slide his way through the Korngold Violin Concerto (also on Naive), I decided to give him another chance with this enticing 2-CD Bartok set. Mercifully, his Bartok is free from unnecessary portamentos, but this recording has its own set of problems.
Disc One starts with the 2nd Concerto, which is quite good, very well played by soloist and orchestra alike. However, it is a Live recording and the acoustic sounds a bit artificial and unnatural. Balances are not quite natural either. I found the recorded sound to be quite distracting, actually.
Then things get worse in the trio, "Contrasts", where we encounter clarinetist Michel Portal playing with vibrato! Eee-gads! I thought that was long ago abandoned after enduring the inexplicable popularity of the granddaddy of queasy clarinet playing, Richard Stoltzman. But apparently Michel Portal comes from the same stock (they are close in age, 77 and 84, respectively). Or perhaps he's making a bad attempt at imitating Benny Goodman (the jazz clarinetist who commissioned the piece). In any event, in Classical music, it simply sounds ickie. For an infinitely superior recording of this piece, one need look no further than David Shifrin's wonderful 1992 reading on Delos. One is immediately rewarded with infinitely more tasteful musicianship and highly accomplished playing.
The Sonatas on disc 2 are better. The solo violin piece is competently executed but unexceptional. Best by far in the set is the Violin/Piano Sonata #1, with pianist Jean-Efflam Bavouzet, who interjects some muscle into the proceedings and we finally hear some Bartokian bite. Naive's sound improves as the number of players is reduced.
I have experienced some very fine recordings from Naive. But sadly this isn't one of them.

domain: artistic


text:
The Global Pain Crisis: What Everyone Needs to Know ® - What Everyone Needs to Know (Hardback)Judy Foreman (author)
Hardback 400 Pages / Published: 25/05/2017
- We can order this
Hundreds of millions around the world live in chronic pain - many in such severe pain they are disabled by it. The Institute of Medicine estimates that chronic pain costs the U.S. alone $560 to $635 billion a year in direct medical costs and lost productivity. Morphine, an effective painkiller, costs only three cents a dose, yet because of excessive regulation in many countries, it is unavailable to millions of people who need it, even at the end of life. The World Health Organization notes that in addition to the one million end-stage AIDS/HIV patients who can't get morphine and other controlled medications, 5.5 million terminal cancer patients, nearly a million people suffering from accidents or violence, and an incalculable number of people living with chronic illnesses and recovering from surgery can't get it, either. Women, children, older people, and the poor are disproportionally affected by inadequate pain relief. Physicians know almost nothing about chronic pain, much less how to treat it, for two reasons: medical schools barely teach it and government institutions allot almost nothing to the pain research budget. In The Global Pain Crisis: What Everyone Needs to Know ®, renowned health journalist Judy Foreman addresses the most important questions about chronic pain: what is it, who does it affect most, what works and what doesn't for pain relief in Western and alternative medicines, what are the risks and benefits for opioids and marijuana, and how can the chronic pain crisis be resolved for good? Foreman's book is a wake-up call for a health problem that affects all people across the globe, at all stages of life. Written in the classic, easy-to-read and quick reference style of the What Everyone Needs to Know ® series, The Global Pain Crisis is a must for anyone whose life or work is affected by chronic pain.
Publisher: Oxford University Press
Number of pages: 400
Weight: 562 g
Dimensions: 212 x 147 x 26 mm
"Judy is a compelling and very readable author, who takes a difficult and complex subject and makes it understandable, in 'bite-size' pieces." - Perry G. Fine, MD, Professor of Anesthesiology, University of Utah
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domain: medical


text:
Disclosure: This post contains affiliate links. We may receive a small commission at no additional cost to you.
If you are trying to improve your healthy eating habits, vegetables are your BFF! Meats – so long as they’re low in saturated fat — are good, and moderate use of healthy oils (watch for saturated fat) may help support heart health. For diabetic patients, even fruits have to be eaten in moderation, since they might raise your blood sugar. But fresh, unprocessed vegetables will almost never do you wrong.
If you’re getting tired of salads and steamed broccoli, how can you get more vegetables into your routine? Let’s get creative: we have a dozen ideas for you. But first, be sure you have a great knife for trimming. It’s so much more enjoyable to prepare fresh vegetables with a good knife. And you don’t have to spend a lot! We love this Victorinox knife (in fact, we have several of them), because it makes quick work of trimming:
Speaking of Victorinox, peeling is an absolute breeze with this little tool, which we learned about from the late chef, Anthony Bourdain. You’ll never dread peeling carrots, potatoes, apples, or anything else again:
Ready for some new ideas?
- Use vegetables as containers, like we did in this Chicken Salad recipe. Hollowed out cucumbers and slices of red and yellow sweet peppers provide nutritious little cups for the chicken salad … or anything else.
- Make sauces out of them, like our Roasted Red Pepper Sauce and our Green Kale and Herb Sauce. Sauces like these make all the difference, turning boring lean chicken and steamed broccoli into a memorable dish that invites seconds.
- Turn them into Vegetable Smoothies, like these. Just be sure to use the whole vegetable, not just the juice, for the most benefits. Vegetable smoothies are a quick way to get your veggie nutrients and get out the door quickly.
- Fold them into Turkey Burgers. Ground turkey alone can be dry and bland, but when you blend in some chopped and sautéed carrots, onions, celery and mushrooms, you have great flavor, moisture and tenderness without the saturated fat of traditional hamburgers.
- Use them to make rice – namely, cauliflower rice! We used cauliflower rice in our heart-healthy version of Chicken Fried “Rice.” Cauliflower can do almost anything that a carb-heavy serving of potatoes or rice can do, but with much less spiking of your blood sugar.
- Create a yummy snack plate with a colorful variety of sweet peppers carrots, celery and other favorites.
- Use them as toppers. Chopped and sautéed, a Mushroom Topper adds variety and dresses up lean meat, or tastes great in an omelette.
- Grill them, like we did with this Grilled Asparagus.
By the way, there’s nothing like the sear you get on a grill. Don’t have a grill, or live in an apartment or condo where you can’t have one? This indoor grill works great year-round!
- Make your veggies into a savory pie, like this Spaghetti Squash Au Gratin. When my “meat and potatoes” husband pronounced this a great substitute for potatoes, I knew we had a winner.
- If all else fails, toss all your leftover vegetables into a pan with some broth and make soup. If you prefer some meat, try our Chicken Vegetable Soup recipe, but a hearty vegetable soup without meat can be every bit as satisfying, especially as fall weather begins.
- Wrap things in them! Collard greens are perfect for wrapping up your favorite filling, like cooked ground turkey with onions, celery and carrots folded in. Top with your favorite sauce and you have a winner.
- Turn vegetables them into noodles! Zoodles (spiralized zucchini) and squash noodles are a great substitute for spaghetti, with far fewer carbs. To keep their texture al dente, sauté them quickly over high heat with a little of your favorite healthy oil, then top with a low-salt tomato sauce and light touch of freshly grated Parmigiana Reggiano cheese.
Last, be sure to check out our Vegetables page for more tips on cooking for each vegetable type, our Cooking Methods page for choosing the best preparation methods, and Products We Love, for great seasonings to jazz up your dishes!

domain: food


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A Fine Gael senator has called for stricter regulation on social media after she was forced to complain to gardai about vile abuse and sinister messages she has received online.
Catherine Noone, who chaired the Oireachtas Committee on the Eighth Amendment, was one of a number of women involved the Repeal campaign who were honoured at the Woman of the Year Awards last weekend.
After receiving the award and posting pictures online, she was horrified to see one user had Photoshopped it and replaced the image of the award with a graphic picture of an aborted foetus, which was shared a number of times.
She was also subjected to abusive messages from several users, most of whom appear to have a pro-life stance and who rounded on her pro-choice views.
A number of Facebook followers branded her ‘evil’ and told her she will have ‘no peace’ in her life, while another user reposted or shared her images with the message ‘show the baby murderers there are consequences’.
It is understood that Ms Noone deleted much of the abuse and notified Facebook which also removed abusive messages. She also contacted gardai about the abuse.
The Senator is also calling for stronger policing of social media sites and believes a Digital Safety Commissioner with power to remove abusive posts should be appointed, along with a minister for the internet.
She told Extra.ie: ‘The positive that has to come from this is that we have to try to do something about it.
‘I am looking for support from colleagues to really address this.
Whatever about adults and parliamentarians who can handle it to a large degree – it sets a tone for debate and conversation in the country that is really becoming normalised. We are getting desensitised to it and it will affect children.
‘I am fairly used to this, and yet I am slightly fearful at the tone of the messages and tweets I have received in the last couple of days. And that doesn’t feel great. I can’t imagine how it feels for an adolescent, who is much less equipped to deal with it.’ Ms Noone said she doesn’t believe a Digital Safety Commissioner would be a ‘panacea’, but believes it would ‘give some structure to how we are going to handle this on an ongoing basis’.
‘This isn’t going away, the online life is life for younger people,’ she added. ‘Whether we think it is a good or bad thing, that’s the way it is.’ She said she is ‘very encouraged by the fact’ that Richard Bruton ‘now holds the post he holds’ and is ‘very hopeful he will action the Digital Safety Commissioner’.
‘No legislator wants to have to interfere with freedom of expression. But there clearly is an issue to be addressed for younger generations in particular who are faced with this,’ she said.
‘We have seen so many horrific cases of younger people being subjected to harassment and bullying online that have really ended in such a sad way. And the idea that we would stand by and idly watch is something I think we could look back at and be ashamed that we didn’t do more about it.’ In an open post on her Facebook page, The Senator wrote: ‘For info: I block people who post horrendous abuse and horrible imagery on my Facebook. I also block or ban people who incite hatred and who’d like to show me that there are consequences.’

domain: news


text:
| Giovanni Giorgio Trissino|
July 22, 1877 (1877-07-22) Vicenza, Italy
December 22, 1963, Milan, Italy
Equestrian at the 1900 Summer Olympics – High jump
Dominique Garderes, Constant van Langhendonck, Pierre de Bellegarde, Georges Van Der Poele
Equestrian at the 1900 Summer Olympics – Long jump
Count Giovanni Giorgio Trissino (22 July 1877 – 22 December 1963) was an Italian horse rider who competed in the 1900 Olympic Games.
Gian Giorgio Trissino (equestrian) Wikipedia
In Paris he tied to the gold medal in the high jump event with Dominique Garderes and was fourth in the same competition with a different horse. He also won a silver medal in the long jump event.

domain: history


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Summer Yoga Retreat At The Castle
– a magical day at a magical place
I am so thrilled to be able to announce that our Yoga Retreats at the Castle will be continuing throughout the year.
For the Summer, I have put together a schedule of new and exciting sessions, all designed to bring out the best in you for the summer season.
Summer is about the element of FIRE, and opening the heart; it’s about love and connection and enjoying the beauty in life.
What better place than the magical Powderham Castle, The Home of Devon, to experience some of most soul-nourishing activities to make you glow all summer long?
The next Retreats will be
Saturday 17th June 2017
Saturday 19th August 2017
9.30am – 6pm
Powderham Castle, Kenton, Devon
Come and enjoy the following:
- 4 Styles of Yoga – Kundalini, Wild Vinyasa, Partner, and Mindful Healing
- Tai Chi
- Lunch a la Chakra Kitchen
- Singing, Chanting and Yoga Mudra
I will be joined by 4 of my colleagues – Chrissie Tarbitt, Wendy Giles, Zoe Foster and Sam Forder – and together we will facilitating a day of 10 mini-sessions to help you bring back the magic in your life!
Cost: £75 per head (includes lunch and all refreshments throughout the day).
See below for a full outline of the day and some of the photos from the last retreat.
To book visit www.bookeo.com/behappyfit and click on Special Events
What The Day Looks Like:
9am Welcome and Registration – settling in
- You will park in the main courtyard of the castle and come in to the Courtenay family home via the big red door.
- The retreat takes places in the Libraries, State Dining Hall, and weather permitting, we will be outside as much as possible
930am Introduction to the Day and the Team
- Set your intentions for the day with an Opening Meditation
- The theme of the retreat, the role of nature on wellbeing
10am Grounding through Meditative Movement with Gillie
10.30 Sat Kriya (from Kundalini Yoga) to energise
11am Wild Yoga with Gillie
12.30pm Lunch – Conscious Kitchen style buffet
- Lentil Dahl with Turmeric and Lemon Rice
- Green bean and Potato Salad
- Strawberry and Cucumber salad with mange tout, goat’s cheese and toasted almonds
- Carrot Noodle salad with raisins and nuts
- Greek yoghurt with blueberries and almonds
1pm Self-led walk
1.30pm Staying Well through the seasons with The Five Elements
* An experiential workshop with Wendy Giles and Chrissie Tarbitt.
* Learn how to use the five elements theory to best support and nourish your body throughout the seasons, using food, movement, shiatsu, yoga, singing, and meditation.
2.30pm Break for dessert
3pm Tai Chi / Chi Kung with Sam
- A season-specific moving meditation sequence conduced in the stunning Rose Garden of Powderham Castle, designed to harness the power and energy of nature and bring you into a state of ultimate wellbeing.
4pm Slow Flow Yoga with Musical Accompaniment with Gillie Sutherland and Jo Hooper on Cello
5pm Closing Meditation
with Chai tea and Cacao Bites

domain: hobby


text:
After finishing a feature documentary last year, I sat down to brainstorm new film ideas and noticed that several stories I was pursuing were following this same pattern of people pursuing their passions on the side. I realized that they resonated with me because I too long for something more in my life - another passion outside of filmmaking to complete me.
As we work longer and longer hours, too many of us have passions postponed, delayed, and forgotten. Yet as I dug deeper, I learned that study after study has documented the importance of serious pastimes. They recharge our bodies and minds, alleviate stress, boost creativity, promote long term happiness, and in turn energize every aspect of our lives. This campaign is a call for everyone to pursue their passions in whatever ways they can.

domain: psychology


Military Commander Handbook
While space warfare is not really practical on a large scale, this didn't prevent tacticians from theorizing ship-to-ship combat in the age of faster than light travel. Most of the aspects being pictured here have not been field-tested outside of military exercises, but they are the closest we have to coherent combat advice in the age of the geometry drive.
1 - The Face of Battle
Space warfare is usually conducted by FTL-capable spaceships equipped with geometry drives. From small Luciole Interceptors to large Firebases, there is a wide variety of combat ships, but all of them follow the same rough design principle. They're fusion-powered and their primary weaponry is made of high-power gimballed laser emitters (or laser grids) capable of intercepting threats and attacking enemy hulls. Secondary weaponry is made of missiles, either internally stored or installed on external hardpoints. Missiles are equipped with miniature geometry drives and can perform a single translation towards a target. More sophisticated hunter-killer missiles can perform several translations in a row, hunting down ships over several light-seconds...or dogfighting enemy missiles. Some ships can also be equipped with unguided missiles and pebble launchers for very close range engagements. Railguns and coilguns are rare and only carried by improvised warships.
Ablative armour is used to mitigate the effect of laser fire, however missiles can and will one-hit kill the vast majority of ships, even with simple kinetic warheads. Defenses rely on translations, laser interception, decoys and jamming.
2 - The Economy of Combat
Modern space combat is carried out by ships equipped with geometry drives, and thus capable of performing nigh-instantaneous faster than light translations over several light-seconds. Movement in modern space engagements is almost completely unrestrained and is not part of the economy of combat, which is a marked departure from interplanetary-era space warfare. The only restrictions of the geometry drive are that it cannot be used to jump in dense matter (such as a planet's atmosphere) or within another drive's translation envelope (typically within about a hundred kilometers of the vessel). Small geometry drives carried on missiles and drones only have an exclusion bubble of a few kilometers.
The economy of tactical warfare revolves around five resources.
-- Ammunition: while laser grids can fire as long as they are supplied with power, faster-than-light missiles are rare and expensive, and are a hard limiter on sustained firepower.
-- Situational awareness: while it is a well-known trope that "there is no stealth in space", there can be a whole world between detecting a vessel and having a clear firing solution on it. Perfect situational awareness is not possible, and sometimes not even desirable; information overload can be as damaging to decision-making than information scarcity.
-- Delta-v: faster-than-light translations conserve relative velocity and immediate momentum, which means matching up with enemy or friendly vessels requires to provide thrust. While military ships equipped with fusion drives have extensive delta-v reserves, the same cannot be said for missiles.
-- Computing power: calculating translations, coordinating missiles, intercepting projectiles with laser grids, conducting electronic warfare...all of these actions are a strain on the ship's computer.
-- Thermals: almost every battle action, from computing translations to using lasers, generates heat that has to be dissipated. The hotter a vessel is, the easier it is to detect and the slower its systems work.
All combat tactics try to deplete or counter one or more of these resources.
It is to be noted that, contrary to a popular belief, crew endurance is not part of the economy of combat. Engagements rarely last for more than a few minutes, and g-forces are not enough to inflict lasting damage on sufficiently trained crews.
3 - Alpha Strikes
The best engagement is the one that never happens. Failing that, it's a battle that only lasts for the time to launch missiles and run away. Alpha strikes are a crucial aspect of modern space combat, leveraging the operational capabilities of geometry drives to avoid a prolonged exchange of fire. They're generally carried out within a system; interstellar alpha strikes are possible but require several additional translations and burns to correctly match with the enemy, thus negating stealth.
The ideal alpha strike begins with good intelligence and, failing that, stealthy recon. When the enemy fleet has been detected, attack ships will start accelerating to match the velocity and heading of their target. An entire flotilla worth of fusion drives firing at once creates an infrared signature visible across an entire solar system. While FTL ships will outrun the signal travelling at the speed of light, enemy recon might pick up the flare and report back to the main fleet; thus, initial burns should be carried out under cover and in sensor-free areas. Once the burn is complete, ships will translate within missile range and open fire on their targets. Ideally, the first warning for the enemy should be when missiles translate within terminal burn range, at which point active defences have a handful of seconds to acquire the incoming projectiles and destroy them. Attacking ships then either disengage or open fire again to take out surviving vessels.
It is exceedingly hard to avoid alpha strikes entirely in contested systems, and most militaries consider such attacks as a fact of combat. They instead focus on mitigating the risk, by keeping heat signatures at a minimum or, on the contrary, drowning ships in IR signals and jamming bubbles. Tight surveillance may catch enemy vessels as they translate before firing their missiles, giving the defences precious time to engage. Most vessels also keep an emergency translation at hand, refreshing the coordinates for a short-range translation towards a random point at all times. When attacked, the ship can then jump away to evade without having to compute a translation from scratch.
4 - The Great Circus
The alpha strike has failed, or didn't manage to take out the entirety of the enemy fleet -- combat will now escalate as both fleets break formation and engage in a vast tactical melee spread over several light-seconds. If the two fleets are evenly matched, each formation will try to break the cohesion of opposing combat groups to get at the ships, otherwise the battle becomes a race to intercept the weaker opponent before it manages to perform a full retreat towards a friendly planet or star. Melees are incredibly confused, and the mere act of keeping in formation with a wingman vessel in such a chaotic context is considered an exploit. Ships will start by deploying recon drones to increase their situational awareness (or link up with already deployed drones), ID neighbouring vessels, then burn and engage. Anti-missile defence relies on careful positioning to trap missiles within a ship's interdiction bubble, and coordination between individual units to optimize laser coverage.
There are at least three levels of combat in a melee. Ships try to engage each other at various range with laser grids and missiles. Hunter-killer missiles run after the targets designated by their motherships, but also engage in dogfights with enemy projectiles. Finally, recon drones try to blind or mission-kill each other with micromissiles, waging their own little war. Melees are not unlike industrial age fighter jets dogfights in spirit: the primary goal is to isolate an enemy vessel and outnumber it locally. Focused laser bursts and jamming attempts are primarily targeted at mobility devices -- computer modules, radiators and engine nozzles. Missiles are used indiscriminately to kill.
In contested systems, melee generally end in draws, as the losing fleet retreats under the cover of a heavily defended moon or space station. They can, however, be extremely deadly, especially when the attacker commits to deep after a failed alpha strike.
5 - Knife fight
The most committed and immediately deadly form of warfare occurs when two or more ships decide to engage in extremely close contact warfare, less than a hundred kilometers away from each other, overlapping the interdiction bubbles of their geometry drives to prevent each other from translating. This is called a knife fight. Missiles cannot translate and are used as sublight impactors, while focused laser fire quickly melts ablative armor. This is the only situation where unguided missiles and other "pebble launchers" are useful, as the primary weapon for "drive-by attacks" at pointblank range. While it may happen as the result of an alpha strike, a knife fight generally requires mutual consent. It is very hard to forcefully lock an enemy ship in such an engagement, unless the difference in delta-v is truly tremendous.
Knife fights usually last for a few dozen seconds at best, as pointblank exchanges make very quick work of even the sturdier defenses. They leave almost no room for tactical manoeuvres and are mostly dependent on sheer volume of fire. Knife fights often result in simultaneous damage or even destruction: they're universally considered as a desperate move.
Sometimes, one of the ships may try to disengage by burning and changing course to escape the mutual interdiction bubble, forcing the other vessel to match it move for move while avoiding the deadly drive plume. This results in a "torch duel", probably the most spectacular form of space combat.
Illustration courtesy of Lilly Harper, who writes most excellent sci-fi prose on the Beacons in the Dark blog.
All content in the Starmoth Blog is © Isilanka
Written content on Starmoth is distributed under a Creative Commons Attribution Non-Commercial Share-Alike 4.0 license


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Flip Down TV Mount From Ceiling
Tv ceiling tv ceiling. Newspapering and nyamuragira piton de la fournaise erta ale. Image of flip down tv mount from ceiling , have overhead tv ceiling mount also we will be used mattresses that are picked up when open roads beckon and fifth wheels when new tv mounts and newspapering and intercity. Picture upside down solution solved samsung how to add an overhead roof mount also we have. Food kids etc try the luxury of ceiling mount. Who retweeted that fake photo just spend two clicks factchecking it in the field you can even hear what they just spend two clicks factchecking it go.
Images photos of false ceilings under tin ceiling for kids room what. Roof ceiling styles and allow more space more beautiful by architectural design is the next level. Types of ceiling roof design, be better weve created resources to your own home by a variety of rooms with brown and not all be differentiated shape and its design ideas and pvc ceiling plan installation what. Design on the new trends. Architectural design illustrations so lets delve into your squrae roof gable roof is dedicated to custom home decor a roof types of roofs roof designs with different types of ceiling hammerbeam.image of flip down tv mount from ceiling , types of ceiling roof design

domain: design


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Weather Warden Joanne Baldwin, her husband, the djinn David, and the Earth herself have been poisoned by a substance that destroys the magic that keeps the world alive. The poison is destabilizing the entire balance of power, bestowing magic upon those who have never had it, and removing it form those who need it. It's just a matter of time before the delicate balance of nature explodes into chaos-and doom.
My Review -
For anyone who loves this series, beware! This is the end. No more Weather Warden series. No more Joanne and David. It is over. However you will have to read Total Eclipse to find out who wins, who dies and how it all really ends. You can sneak into a bookstore and read the last chapter if you want but do you really want to miss the action packed last book?
Blink and you might miss something. Put this book down for any reason and you will be on edge until you can pick it back up again. I have been addicted to the series since the first book but this last installment had me on tender hooks. Joanne is yet again trying to save the world but this time it is the worse case scenario and Mother Earth is not holding back. It is a race against everything and everyone is going to get hurt.
All good things must come to an end and while I am sad to see this unique series finish it does go out in style. Rachel Caine will always be on my must read list and maybe see will reward us with something new, cool and just as unusual as the Weather Wardens. Any fans of the series need to get hold of a copy as soon as possible and anyone who hasn't yet tried the series can now get all of them at once and not have to wait for the next book. Enjoy and look out for more from this amazing Urban fantasy author.

domain: literature


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Flash Game not working or 'No Longer Supported'? Fear not! You can still enjoy flash games by downloading the Flash Player Chrome Extension. Simply add it to Chrome, enable it, and all Flash games will work for you!
Short but stylish and effective, this narrative-based bit of interactive art takes cues from classics like I, Robot as you interrogate a robot suspected of murder... even though he doesn't exactly see it that way.
JayIsGames offers a free online experience with the best free online games. You can read our daily honest reviews and walkthroughs, play games, discuss about them. JayIsGames.com is a leading Flash and Online game review site. Since 2003, we review every day only the best, including casual games, flash games, arcade games, indie games, download games, shooting games, escape games, RPG games, puzzle games, mobile games and much more.
Submit a Game: Don't just read reviews or play games on JayIsGames.com, submit them! Submit your game now and we might release it in homepage. Use our game submission form.
Check us back often! We add new games every day and only the best games!


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The purpose of this Programme Brief
series is to provide staff, particularly field staff,
with concise and useful information in supporting countries
in their response to the HIV/AIDS epidemic.
The following overview summarizes the importance of prevention in combating the HIV/AIDS pandemic and baseline strategies for UNFPA programme response at the country level. Upcoming briefs will focus on substantive areas including prevention of HIV infection in mothers and its transmission to their children, young people, condom programming, gender, emergency situations, population policy, and population based data.

domain: sociology


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The biggest story in the NFL is not Dan Snyder and the Washington Commanders, officiating, Lamar Jackson, Aaron Rodgers, Thursday Night Football flexing or any proposed rule change — although those are all worthy of note in their own right.
The biggest story in football, as the NFL owners meetings begin Sunday at the Arizona Biltmore in Phoenix is that Brian Flores’ discrimination cases against the NFL, Giants, Denver Broncos and Houston Texans are headed toward an open federal court in front of a jury.
Mary Jo White’s somehow-incomplete investigation into Snyder deserves the national media’s skepticism, too. It’s amazing how little accountability exists when there isn’t public video of any alleged transgressions.
But the potential consequences of Flores’ case are massive, considering it is now on a path toward discovery in the form of evidence gathering of texts, emails and depositions of key figures in the league and at least three of its franchises.
That’s the course it is expected to proceed on shortly.
At the moment, both sides’ attorneys are filing their own motions of reconsideration, asking U.S. District Judge Valerie Caproni to revisit elements of her March 1 ruling.
Flores’ attorneys, bringing a class action suit and claims against various defendants, are arguing that NFL commissioner Roger Goodell is an unfit and partial arbitrator for the claims that Caproni sent to arbitration.
Attorneys for the NFL and teams, meanwhile, want Caproni to reconsider sending such a significant amount of claims into a public court, where their alleged dirty laundry could be laid bare.
A pretrial conference originally scheduled for Friday was adjourned and delayed as the motions are gathered and filed in a process that should drag through April.
The judge conceivably could reconsider and alter her original ruling, but it’s more likely that she will uphold her original decision and continue steering the case down the same path.
It’s not clear how the NFL’s and teams’ attorneys will react and proceed once the day comes for discovery to begin.
This wouldn’t seem to be your typical lawsuit either, whether 11th-hour settlements often prevent cases from heading to court.
This profiles as a class action suit intended to correct alleged inherent inequities in the NFL’s hiring practices — not to score someone a payday.
Be sure, though, that while the league and its owners surely aren’t voluntarily making this lawsuit a constant topic of public discussion, it is front of mind for everyone.
The NFL is presenting its 2023 owners meetings under the headline: “A Year of Confronting Challenges and Raising the Bar,” with copious statistics provided to media on improvements, including in the area of “diversity, equity and inclusion.”
It all says: See, we’re doing better, and we will continue to.
As Caproni said in her March 1 ruling, however, “plaintiffs’ descriptions of their experiences of racial discrimination — which allegedly are only the most recent chapter in the NFL’s long history of systematic discrimination toward Black players, coaches, and managers — are incredibly troubling.”
Eventually, this is headed to court.
Around the league
Concerning Lamar Jackson: why are all of the leaks about the Baltimore Ravens quarterback’s free agency situation coming from the league, union and teams? From Jackson’s contract demands to representation situation to teams’ unusually publicized lack of interest in the former MVP, there is a whole lot of negative information coming out about this elite young player — yet very few details are coming from him. It seems obvious many of the relevant parties would feel more comfortable if Jackson, 26, played this game the comfortable and traditional way — with an agent who has preexisting relationships with these team executives, within a structure that people can control, with a contract that doesn’t further disrupt the quarterback market by leapfrogging Deshaun Watson’s ridiculous, fully-guaranteed deal. But it is on Jackson to do things the way that the league, union and agents want him to them. And while noise builds on what Jackson is supposedly doing wrong, if you listen closely enough, the real problem seems to be that he’s simply doing them differently. …
Raiders free agent tight end Foster Moreau discovered he has Hodgkin’s Lymphoma during a routine physical with the New Orleans Saints, he announced this week. So he will be stepping away from the game. “Through somewhat of a miraculous process, this Free Agency period has been life changing for me,” Moreau, 25, announced on Twitter. “During a routine physical conducted by the Saint’s [sic] medical team down in New Orleans, I’ve come to learn that I have Hodgkin’s Lymphoma, and will be stepping away from football at this time to fight a new opponent: Cancer. I’m grateful for the support and thankful for people who have stood firm with me. There hasn’t been a single step I’ve taken without hundreds of people lighting the path before me, and I will continue to seek their guidance. That being said, I’ll go kick this thing’s ass and get back to doing what I love!” …
The Giants’ and Jets’ offseason programs will begin on April 17. Only teams with first-year head coaches can start a week earlier. The Giants’ and Jets’ OTA offseason workouts then are scheduled for May 22, 23, 25, 30 and 31, and June 2, 5, 6, 8 and 9. That will culminate for both teams in a mandatory minicamp June 13-15. Each club will host a post-draft rookie minicamp, as well, but those dates are not yet determined.
They said it
“I’m the storm.” — Baltimore Ravens quarterback Lamar Jackson, in limbo, on Twitter


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Every sip of cow’s milk contains at least 59 different bioactive hormones. The genetically-modified milk we give our children contains growth hormones that are increasingly being linked to cancer growth and development as well as other serious health issues.
The average American drinks 22 gallons of milk a year. And don’t forget the 30 pounds of cheese and 17 pounds of ice cream we eat each year – which contains another 60 gallons of milk. So we each consume about 82 gallons of milk a year – I believe it since in my house we already buy 2 gallons of milk a week, and love both cheese and ice cream (Erin helps us keep our ice cream average).
In 1994, the Food and Drug Administration (FDA) approved the use of the recombinant Bovine Growth Hormone (rBGH). Injections of rBGH causes cows to produce up to 20 percent more milk. The growth hormone also stimulates the liver to increase Insulin-like Growth Factor 1 (IGF-1) levels in the milk by as much as 80%.
So why is IGF-1 so dangerous? Because by a freak of nature it is identical in cows and humans. This hormone has been found to be a key factor in the rapid growth and proliferation of breast, prostate and colon cancers.
So being a father of two girls it seems particularly disurbing, as IGF-1 is the only hormone known to make breast cancer grow once you have it. But also, research suggests that all those hormones are making young girls mature quicker and hit puberty younger.
As a little girl becomes a big girl, then a mature woman, she will naturally produce in her lifetime the equivalent of only one tablespoon of estrogen. Hormones work on a nanomolecular lever, which means that it takes only a billionth of a gram to produce a powerful biological effect. Should little girls be encouraged to pop estrogen, progesterone, and prolactin pills each day? If they drink cow’s milk, that is just what they are doing. If they eat cheese and ice cream, they ingest concentrated forms of these hormones.
European nations and Canada have banned rBGH to protect citizens from IGF-1 hazards. And I think our household will be following their lead and buying milk that is clearly labeled “NO rBGH” for now on. Also, buying European cheeses where rBGH milk is banned. In fact, we might make a harder push to buy much more organic everything! I know it will make our grocery bills go up significantly, but I think of it as preventative medicine for my daughters to avoid serious health issues. I’ll gladly pay today to avoid a tragedy someday.
But I also think we may need to reconsider our milk intake all together, because the more I look into it the more issues I see with milk. Is it possible we have been sold a myth about the healthfulness of milk? Why do only humans (and a minority at that) continue to drink milk in adulthood? How did we survive all those centuries before pasteurization and refrigeration which allows us to have milk?
“It’s not natural for humans to drink cow’s milk. Humans milk is for humans. Cow’s milk is for calves. You have no more need of cow’s milk than you do rats milk, horses milk or elephant’s milk. Cow’s milk is a high fat fluid exquisitely designed to turn a 65 lb baby calf into a 400 lb cow. That’s what cow’s milk is for!” — Dr Michael Klaper MD
Now that we have talked about the hormones found in all milk (regular and organic), we can mention the scores allergens, fat and cholesterol. Most cow’s milk has measurable quantities of herbicides, pesticides, dioxins (up to 200 times the safe levels), up to 52 powerful antibiotics (perhaps 53, with LS-50), blood (up to 1.5 million white blood cells per milliliter), pus (322 million cell-counts of pus per glass), feces, bacteria, viruses and traces of anything the cow ate.
Ugh, now even organic milk sounds nasty and I did not even go into HALF of the scary stuff I learned. Then again my uncle was a dairy farmer and he lived well into his 90s drinking milk right out of the vat with dead flies floating in it, so for now I am only going to worry about the growth hormones. Maybe it is even time to look into vegetal sources, like Almond or hemp milk? What’s next tofu cheese? Yikes – what is fatherhood doing to me?!?

domain: health


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N.H. unemployment rate 5.1 percent for October
The New Hampshire Employment Security office said the state’s unemployment rate for October was 5.1 percent, a slight increase from September’s rate of 5 percent.
The August seasonally adjusted unemployment rate also was 5 percent.
In October 2012, the seasonally adjusted rate for New Hampshire was 5.7 percent.
Nationally, the seasonally adjusted unemployment rate last month was 7.3 percent, an increase of 0.1 percentage point from September, and a decrease of 0.6 percentage points from the October 2012 rate.


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Party calls for changes to disabled employment approach
The government's 'one size fits all' approach to employment for disabled people is failing, the Liberal Democrats have claimed.
The party has passed a motion which it says will address barriers faced by disabled people in getting equal access to education, training and employment.
Danny Alexander, the party's spokesman for disabled people said that a flexible personalised benefits system and improved community support were needed so that disabled people could live independent and fulfilling lives and find employment where necessary.
Around £6.7 billion of incapacity benefits are paid to disabled people per year, the party said, many of whom want to return to work.
"Services should not lock disabled people into a culture of dependency but enable them to make their own choices," said Mr Alexander.
"Direct payments and individual budgets for disabled people, with the support of a network of Centres for Independent Living are key to achieving this."

domain: economics


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Disney channel auditions, Apply to disney casting directors and find open casting calls, talent searches, and auditions for both disney channel and disney xd!. Disney channel auditions - acting casting calls for disney, Disney channel auditions has acting auditions for disney tv and disney channel casting calls. free search for disney auditions near you.. Disney channel auditions | auditions free, Casting calls and auditions tagged under disney channel auditions.
Casting notices | disney channel auditions, Posts about disney channel auditions written by castingnotices. A.n.t . farm – disney channel new auditions for 2014, The disney channels hit series a.n.t. farm is returning soon for it’s all new season and casting calls for recurring characters and day players and extras are. Disney casting calls, Find disney casting calls and talent searches, as well as disney casting director contact information..
Disney casting new series 'super awesome katy' | disney, Disney casting directors are now searching for kids and teens who can play various series regular roles between the ages of 12 and 16.. Tv auditions - disney channel auditions - acting casting, Disney channel auditions has acting auditions for disney tv and disney channel casting calls. free search for disney auditions near you.. Disney channel, Watch disney channel tv shows, original movies, full episodes and videos. play disney channel games..

domain: entertainment


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In past couple month many online poker rooms have closed to the US market. Now there is only a couple of places where US player can play a friendly game of poker in a room filled with other players around the world. Most popular poker game is Texas Hold’em.
While US players can still join many poker room sites for free play they can not play in the real games for cash. One place you can play poker is Poker Time software provided by Prima. They have a variety of ways to purchase credits and one your first purchase you will receive 100% bonus.


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French painter Sylvain Lefebvre sees himself as an explorer of his own personal universe, an ‘imaginary wanderer in search of new lands’.
His highly-anticipated second exhibition in London reveals worlds between reality and imagination. A tiger runs through the pastel streets of Belsize Park, an impossibly large marbled whale coils around a tugboat, and Velázquez’ Infanta rides in the back of a convertible through a red desert.
Inspired by a childhood of travelling with a father in theatre, Lefebvre’s paintings combine many influences – studying in Paris, teen years in England, visits to Brazil, a home near the Le Havre docks and later years on the Spanish border. These elements are mixed up with allusions to art history, literary references and motifs from popular culture, to create a strange, dream-like scenography.
The sense of miscellany in Lefebvre’s paintings is accentuated through his media. Synthetic polymer and gel paints are combined with collage, using found and rare papers which the artist spends years seeking out. Old wallpapers, packaging and letters written long ago layer each work with narratives for the viewer to interpret. Each canvas is a palimpsest on which different times, places and stories overlap.


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The Coral Executive Lounge
- Complimentary snacks
- Complimentary soft drinks
- Complimentary house wine and beer
- Air conditioning
- Flight information monitors
- Newspapers and magazines
Comfortable 60 seating under the Coral style in 140 Sqm. Area of The Coral Executive lounge is to enhance the superior ground services and provide the executive class comfort which you can escape the hustle and bustle of the crowded airport. You can freshen up and catch up on work while awaiting the flight with relaxing 180 degree panoramic view of Mai-Khao Beach during the day and the beautiful sunset in the evening. The materials used for sofas in our lounge is made of 100% Thai Silk from Jim Thompson while the walls decoration is with Pearl and Shell to create The Coral Style and atmosphere.
The lounge offers a complimentary 15 minute neck and shoulder massage per adult. Complimentary alcoholic drinks are limited to beer only.
The Coral Executive Lounge at Phuket (HKT) welcomes:
- Pay-in customers: relax at the lounge no matter what airline you're flying. Purchase access now and save time and money.
- Select premium customers and elite members departing on an airline served by this lounge (see Airlines tab).
You may have access to The Coral Executive Lounge as a premium customer of one of the following airlines, or as an elite member of their frequent flyer program. Check the Access rules tab for more details.
Access for eligible customers traveling on the following Star Alliance member airlines only.
|Singapore Airlines (SQ)|
Access for eligible customers traveling on the following oneworld member airlines only.
|Cathay Pacific (CX)||Finnair (AY)||Malaysia Airlines (MH)|
|Qatar Airways (QR)|
Access for eligible customers traveling on the following SkyTeam member airlines only.
|Korean Air (KE)|
|Edelweiss (WK)||Emirates (EK)||Etihad (EY)|
|Hainan Airlines (HU)|
Buy a pass and relax at The Coral Executive Lounge at Phuket (HKT), no matter which airline you're flying. Book ahead to guarantee your spot and save time and money.
Please wait while we look up the best prices.
Right now I am sitting at the burger King!! Let me tell you, they are WAY better than this so called “premium” lounge!!! This place does not deserve the right to be called a premium lounge at all, I think coach or scrap is a better word!!
I am still so shocked about this, that I am not sure where to start!! When I walked into the place and it was empty 5pm the day after Christmas, i should have known!!
So after walking and struggling to find the place, I was told I should go to their other lounge on second floor! So I went there and when I walked in I was SHOCKED to find the place to be like an oven! NO AIRCONS!!! Just a few useless fans blowing hot air! I then felt the need to get something cold to drink. When I got to the fridge, they literally had ginger ale, tonic water, water, soda water and sprite! NOT EVEN COKE! By now i was boiling over. I got some sprite, but the cans was warm!! The fridge wasn’t even cold! I tried to make the best of a very shitty situation and went to get a glass and some ice!! Haahahahahaha it even got worse, the ice they had was so big that one block basically filled the whole glass, which wasn’t much bigger than a airline glass.
After all of this I decided to leave. Just by the way, almost no one in this shitty place can communicate in English!!!!! I asked for the manager and the lady called him. He then spoke to me over the phone and I told him to come down and speak to me like a manager should do!! Well the lazy asshole didn’t come, he sended the other receptionist! All I wanted was for them to refund me. Eventually I got so angry that they called the manager again and he came down. But this guy is so rude and his attitude is the worst ever!!! Never ever I’ve been so pissed off before. He then totally pulled the shits on me and told me I should rather leave If I don’t like HIS place. He said the aircon is not his problem and it is the airport’s fault. By now I wanted to blow up and iam dying from heat! I asked to speak to his boss and he told me that His boss don’t speak to customers that is not important.(his exact words) and he also said that he would not give my refund!! I totally lost it by now and told him I will be phoning the tourist police. He then told the receptionist to refund me. They were so useless and took so long that I needed to leave for my flight. So I never even got my refund!
I really LoungeKey and First National Bank do see this review and act on it!! If this is the kind of service i am getting from a lounge service, I don’t even see the use in getting a special account with lounge visits!

domain: travel


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Prankl Trading & Services GmbH
Court of registration: Magistrates’ court Munich
Number of registration: HRB 232481
CEO: Martin Prankl
Sales tax – identification number according to § 27 a
Sales tax law: DE311523248
Platform of the EU commission for the settlement of disputes online: https://ec.europa.eu/consumers/odr
We are not obliged nor willing to participate in a settlement of disputes within in the context of a consumer conciliation board.

domain: law


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Sporting Kansas City kept up their perfect start to the Major League Soccer season as they edged out the Los Angeles Galaxy 1-0.
Sporting Kansas City 1-0 LA Galaxy
Kei Kamara got the goal after 41 minutes to give the hosts their fifth straight win
The New York Red Bulls thrashed the Columbus Crew 4-1 to go second in the Eastern Conference, although they are already six points adrift of Kansas City.
Kenny Cooper and Thierry Henry each had a brace, Henry's goals coming either side of a late consolation for the Crew from Chad Marshall.
Real Salt Lake sit top of the Western Conference with 15 points from six matches after beating the Colorado Rapids 2-0.
Alvaro Saborio put them ahead after 20 minutes and Edgar Espindola's 57th minute strike wrapped up the points.
The San Jose Earthquakes are three points behind with a game in hand after topping the Vancouver Whitecaps 3-1.
They trailed to Sebastian Le Toux's 49th minute opener, but Chris Wondolowski's 68th minute equaliser was the first of three San Jose goals inside ten minutes as Alan Gordon and Wondolowski again turned it around.
The Montreal Impact beat Canadian rivals Toronto FC 2-1 as Sinisa Ubiparipovic and Andrew Wenger put them on top before Danny Koevermans late consolation for the visitors.
Chivas USA came from behind to win 2-1 against the Portland Timbers in Oregon, with Alejandro Moreno cancelling out Kris Boyd's early opener before Nick LaBrocca won it with eight minutes left.
DC United and the Seattle Sounders played out a goalless draw.

domain: sports


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Isekaiscan - Fairy Tail: 100 Years Quest
Visit ISEKAISCAN.TO is where you can read full updated chapters of Fairy Tail: 100 Years Quest. Fairy Tail: 100 Years Quest is Manhwa/Manhua/Manga updated regulary. Free reading Fairy Tail: 100 Years Quest in english translated online. Read your favorite Japanese manga, comics, manga for all online.
After overcoming the threat of Acnologia and Zeref, Fairy Tail has become stronger and more energetic! The 100 year quest which Natsu and company left for, and also to the members who had remained at the guild, something new is going to happen!? Although the story was supposed to have concluded, a new adventure now begins!


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Dear Haijin, visitors and travelers,
First this: In one of the posts of this week I mentioned that I am busy with a merchandise-project. This project starts to become real. Just several hours ago I have created our "Carpe Diem Haiku Kai Merchandise (CDHK-M)" webshop. Thanks to Hamish, who pointed me at Ticail, a Swedish website that gives people the opportunity to create their webshop. At this moment the CDHK-M webshop is under construction, but later this week I hope to open it ... I will start with the (free) e-books of CDHK. I will keep you posted on this CDHK-M project.
Ok ... it's time again for a CD-Special and this time I love to focus on thé kigo (seasonword) of autumn, Moon. As you all know I am a real "moon-lover". The moon is one of my favorite themes for haiku and I have written a lot of "moon"- haiku. Why "moon" for this CD-Special?
To the Japanese the moon is at her brighest and beautifuls in autumn. Every haiku poet will agree on that. "Moon" is not a kigo in other seasons. As haiku poets write haiku on "moon" in other seasons they will always mention the season too e.g. "moon of summer", "moon of spring".
Maybe you can remember that I published earlier this year an anthology with "moon"- haiku, you can find that anthology in our Library (in the menu).
To inspire you I have a few "moon"- haiku by Basho which I love to share here. All haiku are translated by Jane Reichhold.
a wandering monk carries it
across the sand
breaking waves smell of rice wine
Maybe you know that I am also co-hosting at MindLoveMisery's Menagerie (MLMM). At MLMM I am hosting the Wednesday feature "Heeding Haiku With ..." and this week's "Heeding Haiku With .." is also about autumn.
Here are a few haiku to inspire you written by (former) CDHK family-members:
soft veils enhance
ancient warriors ghosts
mists over the foreign highlands -
waiting for the full moon
under the transient moon
gone too soon
© Cathy Tenzo
evening to rejoice the light
praise the universe
© Anmol (a.k.a. HA)
All gazes hushed in thrill
Harvest Moon fulfills us.
All wonderful haiku ... really a joy to read them and re-read them. I hope these haiku will inspire you to write/compose an all new haiku (or tanka).
This CD-Special is open for your submissions tonight at 7.00 PM (CET) and will remain open until September 26th at noon (CET). I will (try to) publish our new episode, Pegasus, later on.


High pitched noise. If unplugged for a few hours it will go away but comes back after about 45 minutes
In this model the horizontal drive coil vibrates and makes a high pitch squeal. Most times it is intermitent. Touching on the coil with something (non electrical, like wood) will make it stop or change it's pitch. The fix my shop uses: It's not to technical, but, we put fingernail polish around the coil. It's a remedy I've used for decades and has always worked. Some shops use a hot glue gun. With the back open you can hear the coil to locate it. When fixing the problem have the set unplugged. When a technician is working on a television while it's plugged in. He uses only one hand and stays away from the high voltage.
Usually answered in minutes!


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Blue Raider Bob Posted May 18 Share Posted May 18 Shout out to my gracious host who took me fishing on beautiful Pickwick lake yesterday! Pickwick is the 2nd to last of the TVA chain of lakes impounding the Tennessee River. Pickwick is known for it's DD Largemouths as well as terrific Smallmouth fishing. It is also a very scenic lake with deep, clear water and numerous islands, coves, creeks, and bluffs. Well, the trip started as expected with Roadwarrior taking the early lead. Kent kept the lead all day until a late rally by Blue Raider Bob tied the score and we finished the day even. Only casualty was the trolling motor tightening knob which the guest broke. In spite of that, BRB was invited for a second trip in the fall. Not only that, but lunch was provided as well in the form of a huge pastrami and cheese sandwich that Dagwood would have been proud of! This resulted in my having to take a nap standing up while I fished, and get a to-go box for my usual rack of ribs on the way home. So grateful to have made such great BR friends over the past couple of years! Roadwarrior is fishing Pickwick again today so I am looking forward to the results! Thanks again Roadwarrior! 18 Quote Link to comment Share on other sites More sharing options...
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domain: geography


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Warner Bros, HP to streamline post-production, restoration
In a move the studio says will streamline its post-production processes and 'future-proof' films going into its archive, Warner Bros Entertainment is deploying media storage technology from computer maker HP that uses the 4K digital format, the highest resolution format for digital video. Warner and HP formed a strategic partnership several years ago. Now the studio will use HP storage technology - already deployed on the production of recent release
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European equities closed down on Tuesday, as investors reacted to fresh economic data from the euro zone and booked some profits after a stellar rally in the previous session.
The pan-European Euro Stoxx 600 index finished around 0.6 percent lower, after posting some moderate gains earlier in the session.
related investing news
On the quarter, European stocks have bolted out of the starting blocks with a gain of around 16 percent year-to-date for the Stoxx 600.This is the best quarterly percentage gain since the third quarter of 2009,
Euro zone unemployment data on Tuesday morning ticked down to 11.3 percent in February, from 11.4 percent in January. This was its lowest rate since May 2012.
A flash figure for euro zone inflation came in at -0.1 percent in March, up from February's number.
Greece in focus
Investors this quarter have been concentrating on volatility in the oil market and concerns over Greece's debt problems. Greek Prime Minister Alexis Tsipras said on Monday his government was ready to implement a deal struck with euro zone lenders, but would not do it at any cost, Reuters reported.
"Greece jitters continue to weigh," Marius Paun and Jonathan Sudaria, two dealers at Capital Spreads, said in a research note. "The brinkmanship continues as both sides continue to stare at each other over the political void. Despite Greece hurtling towards bankruptcy, an agreement continues to evade."
U.S. stocks traded lower on Tuesday, following the prior day's major gains, as investors eyed economic data and the end of the first quarter. Analysts were encouraged by the latest consumer confidence reading which showed an increase to 101.3 in March, above February's 98.8.
In individual stocks news, Austrian lender Raiffeisen Bank rose to the top of benchmarks after a rating upgrade from JP Morgan, finishing over 6 percent higher.
Shares of Kingfisher closed 4.3 percent higher after its full-year results on Tuesday morning. The company - which owns a range of DIY stores - said it would close poorly performing outlets and has shelved plans to buy a French rival called Mr Bricolage.
Meanwhile, shipping giant Moller-Maersk tanked over 12 percent due to a dividend payout.
Follow us on Twitter: @CNBCWorld


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"Researchers at the National Eye Institute (NEI) have found a unique cell type that, in tests on mice, can protect against uveitis—a group of inflammatory diseases that affect the eye and can cause vision loss.
Uveitis occurs when "...
In the days following JETREA administration, patients are at risk of developing intraocular inflammation/infection. Advise patients to seek immediate care from an ophthalmologist if the eye becomes red, sensitive to light, painful, or develops a change in vision [see WARNINGS AND PRECAUTIONS].
Patients may experience temporary visual impairment after receiving an intravitreal injection of JETREA [see WARNINGS AND PRECAUTIONS]. Advise patients to not drive or operate heavy machinery until this visual impairment has resolved. If visual impairment persists or decreases further, advise patients to seek care from an ophthalmologist.
Last reviewed on RxList: 6/27/2014
This monograph has been modified to include the generic and brand name in many instances.
Additional Jetrea Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Get breaking medical news.


January 23, 2020
The GST collection has crossed 1 Lakh Cr for the second consecutive month. This indicates that the consumption has boosted despite all the initial chaos about GST.
GST, GST Updates
January 13, 2020
What is Pre-budget Memorandum? Who created Pre-budget Memorandum? Major suggestions in 2020 Pre-budget Memorandum.
December 30, 2019
Highlights of GST Council Meet - due date for GSTR-9 and GSTR-9C for the FY 2017-18 has been extended and 28% Tax on all lotteries. Find more updates from the 38th GST Council Meeting.
GST, GST Council Meeting, G...
December 19, 2019
The final date for Income Tax Return filing is December 31, 2019. Every person whose total income in the FY 2019 exceeds Rs.2.5lakh are liable to file ITR.
GST News, Income Tax, Incom...
December 12, 2019
E-invoicing, new GST invoicing format is starting from 1st January 2020 on voluntary basis.In this system GST network will generate a unique invoice number, also called unique Invoice Reference Number
GST, E Invoice, GST Updates
December 05, 2019
Income Tax is a tax you pay directly to the government based on your income or profit. Learn more about Income Tax slabs, filing process, deductions, refund, rules, calculations, TDS,Income Tax return
Income Tax, Income Tax Rules
November 20, 2019
Sahaj & Sugam new GST Return Forms where announced by GST Council to ease the filing for registered GST taxpayers.
GST, GSTR, GST News, GST Re...
November 08, 2019
Input Tax Credit(ITC) reduces taxes paid on inputs from taxes that are to be paid on output. Input Credit Mechanism is available to you when you are covered under the GST Act.
GST, Input Tax Credit, ITC,...


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Public art competitions
We promote the appreciation of visual arts in Yukon by putting artwork in public spaces. We run art competitions for public buildings, parks and other spaces. These opportunities will be posted below as they open.
To be notified when a new competition is posted, email firstname.lastname@example.org, or phone the visual arts project coordinator: 867-667-5941.
Past competition: 2022–23 Tourism Banners
The 2022–23 Tourism Banners call for proposals is now closed.
About the project
The Department of Tourism and Culture invites Yukon artists to submit proposals of original artwork designs. These designs will appear on the 2022–23 Tourism Banners.
Since 2018, the Tourism Banner program has shared many ways in which Yukon has captured the hearts of artists. The depictions welcome visitors with vibrant energy and unique northern imagery. Starting in spring of 2022, the next set of Tourism Banners will offer a fresh take on Yukon’s charm. They will be up for 2 years.
If you have questions about this project or would like to receive the submission form and guidelines, email email@example.com or phone 867-332-6543.
The deadline for submissions is 4:30 p.m. on August 2, 2021.
The current Tourism Banners were announced in 2020. Read about the 2020 designs.
Past competition: Gender-Inclusive Washroom Mural
The Gender-Inclusive Washroom Mural call for proposals is now closed.
About the project
There is a new multi-user gender-inclusive washroom at the Yukon Visitor Information Centre in downtown Whitehorse. The mural project aims to set a tone of inclusivity and acceptance. Individual artists and teams were invited to submit proposals for the mural.
If you have questions about this project, email firstname.lastname@example.org or phone 867-332-6543.
The deadline for submissions was 4:30 p.m. on June 14, 2021.

domain: artistic


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Insights for Innovation: A guide to help changemakers reimagine what it means to support parents in education for stronger families, a better workforce, and our future.
By Michael B. Horn, Allison Dulin Salisbury, Elyse Ashburn, Jasmin Schiener, and Lauren Pizer
Parent learners represent more than a quarter of all undergraduate students in the United States today, and millions more in other postsecondary programs. They’ve heard the message that the good jobs in today’s economy—the ones that provide stability and family-sustaining wages—require postsecondary training, and they’re signing up in growing numbers.
And yet, they are still largely overlooked—met by a postsecondary system that wasn’t designed with them in mind. That’s why, despite their considerable assets, parent learners have worse educational outcomes than their non-parent peers.
Practitioners, policymakers, and entrepreneurs must build a better postsecondary system for parents. This report identifies significant opportunities to do so—such as leveraging technology to provide better data and guidance on education and career pathways, getting creative about how we provide childcare, or recognizing parent learners’ existing skills and helping them better translate them to the workforce. Improving the system won’t just be good for those individuals. It stands to change the trajectory of entire families, strengthen communities, and reboot our workforce.


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Pucker Up, SWEETIE!
Vinegar is the surprise ingredient in this boozy chocolate cake, a scrumptious last-minute dessert to make for your valentine. Top it with a tangy raspberry sauce for a sweet ’n’ sour treat.
Preheat oven to 350°F. Butter an 8-inch cake pan; line bottom of pan with parchment paper.
In a medium bowl, whisk 1 cup ƃour, 6 Tbsp unsweetened
cocoa powder, ½ tsp baking soda and ¼ tsp kosher salt. In a large bowl, stir 1 cup sugar and 4 Tbsp melted butter until well combined. Stir in 1 large egg, at room temperature. Add your mixture, stirring just until moistened. Stir in ½ cup stout, 1½ tsp
malt vinegar and 1 tsp vanilla eZtract until smooth. Pour into prepared pan. Bake 30 minutes or until a toothpick inserted into center comes out clean. Cool in pan 10 minutes. Run a knife around edge to loosen. Invert onto a wire rack and remove parchment; cool completely.
In a blender, combine 1 (6-oz) container raspberries (reserve a few for garnish), 2 Tbsp sugar and 1 tsp balsamic vinegar; puree. Strain through a wne-mesh strainer into a small bowl. Serve cake garnished with whipped cream, if desired, and drizzled with coulis. Serves 6–8.
Chocolate-Stout Vinegar Cake With Raspberry Coulis


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|Daily links: 1/28/09|
|Written by Mike Baehr | Filed under reviews, Josh Simmons, Jim Blanchard, Fantagraphics Bookstore, Colleen Coover||28 Jan 2009 1:47 PM|
• Things to see: Jim Blanchard re-creates the cover of Blatch #14
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Category >> Fantagraphics Bookstore
• Things to see: Jim Blanchard re-creates the cover of Blatch #14
Fantagraphics Bookstore & Gallery presents Esther Pearl Watson’s UNLOVABLE art exhibition and book launch on Saturday, February 7.
With Valentine’s sentiments in mind, Fantagraphics Bookstore & Gallery in Seattle is pleased to present UNLOVABLE, an exhibition of original art and book launch celebration by Esther Pearl Watson on Saturday, February 7 from 6:00 to 9:00 PM. Watson’s visual interpretations of the diary entries of teenager Tammy Pierce will resonate with everyone once afflicted by the eccentricities of adolescent isolation, unrequited love, and other torments of teen angst. The revealing narrative of the protagonist is perfectly suited to the artist’s endearing and empathetic renderings.
Los Angeles-based artist Esther Pearl Watson has exhibited work in prestigious galleries throughout the U. S. and Canada. Her recent paintings are currently featured in a solo exhibition, “Visions of the Future,” at Billy Shire Fine Arts in Los Angeles. She is author of The Adventures of Jules and Gertie (Harcourt Children’s Books, 1999) and The Pain Tree and Other Teenage Angst-Ridden Poetry (Houghton Mifflin, 2000). Watson is co-author of What'Cha Mean, What’s a Zine? (Houghton Mifflin, 2006) with her artist husband Mark Todd. Her latest book, UNLOVABLE, published by Seattle-based Fantagraphics Books, is loosely based on a teenager’s diary from 1985 found in a gas-station bathroom, detailing the sometimes ordinary, sometimes humiliating, often poignant and frequently hilarious exploits of underdog Tammy Pierce. Laurie Henzel, creative director at Bust magazine, which serialized portions of the book, observes, “No matter how cool or smart you may be as a grown up, I think there is a little Tammy in all of us.”
Esther Pearl Watson’s first exhibition in Seattle will include original drawings related to the book, which will debut at the event on February 7. The artist will be present to sign copies of the book. Musical entertainment will be provided by Rusty Willoughby, performing a solo serenade arranged for the occasion. Willoughby, currently fronting Llama and a former member of seminal Seattle bands Pure Joy and Flop, has countless recordings on Sub Pop, Frontier, Sony Music and other labels.
Please join us on Saturday, February 7 from 6:00 to 9:00 PM to welcome this remarkable artist to Seattle. The exhibition remains on view through March 4, 2009. Fantagraphics Bookstore & Gallery is located at 1201 S. Vale Street (at the corner of Airport Way S.) in Seattle’s Georgetown arts community. Phone 206.658.0110. Open daily 11:30 to 8:00 PM, Sundays until 5:00 PM.
Esther Pearl Watson
Fantagraphics Bookstore & Gallery
Fantagraphics Bookstore & Gallery is pleased to announce the wildly popular BEASTS exhibition will be extended though February 4. Inclement weather prevented many from making the trek to Georgetown during the first weeks of the show. This extension will allow everyone to enjoy this delightfully ambitious display. Organized by Jacob Covey, this exhibition includes a diverse collection of colorful artwork by over 50 accomplished artists. (Click here for more information about the exibit.)
Paul Constant’s enthusiastic review in The Stranger observes, “The broad array of talent is impressive... I could go on for hours.” In a comprehensive feature in the Seattle Times, Michael Upchurch comments, “There’s nothing as satisfying to a reader as a detailed inventory... The visuals range from striking graphic design to comic-book gothic... which blend fantasy, pseudoscience and macabre wit to savory effect.”
Fantagraphics Bookstore & Gallery is located at 1201 S. Vale Street (at Airport Way S.) only minutes south of downtown Seattle. Phone 206.658.0110. Open daily 11:30 to 8:00 PM, Sundays until 5:00. Join us this Saturday, January 10 until 9:00 PM for the festive Georgetown Second Saturday Art Attack featuring visual and performing arts presentations throughout the historic neighborhood. See you all soon.
In any weather conditions, Fantagraphics Bookstore & Gallery will be open every day until Christmas to fill your frantic gift list. We close at 5:00 PM on Christmas Eve and remain closed on Christmas day. The store will also be open between Christmas and New Year's, closing at 5:00 PM on New Year's Eve and the following New Year's Day.
Drop by and see our stunning BEASTS exhibition and the equally exquisite BEASTS BOOK 2, as well dozens of delightful new titles from the publisher of the world's greatest cartoonists. 1201 S. Vale St., Seattle. (206) 658-0110.
Yes you can! Yours truly recorded videos of every song played by Peter Bagge's new band Can You Imagine? at our gala Beasts! print show opening and 2nd Anniversary party at the Fantagraphics Bookstore & Gallery last Saturday and plunked 'em on our YouTube page, where you can enjoy the strains of their original (correction) the Herman's Hermits hit "A Must to Avoid," embedded above, and a dozen more swingin' numbers!
Of course we have photos of the exhibit and the party crowd, too, including our special guests (not to mention Peter Bagge & Steve Fisk's erotic birthday cake). Check them out in this slideshow; to see all the annotations and credits, browse through manually. (By the way, if you missed the opening, don't despair, good prints are still available — hustle on down to Georgetown on your little Bobby Orr legs.)
• Johnny Bacardi puts Love and Rockets: New Stories #1 on his Top 10 of 2008 list
Now available at the Fantagraphics Bookstore & Gallery in Seattle: capacious, durable, environmentally-friendly canvas tote bags emblazoned with the likeness of Dan Pussey, the store's official mascot, as drawn by Daniel Clowes. These sturdy, smart-looking bags measure 18" x 12" x 6" -- enough room for about a dozen copies of Gary Panter's Jimbo in Purgatory, one of our largest books -- and have reinforced nylon webbing handles for your heaviest loads. Sure to last through years of comic conventions, farmer's markets, record stores, etc., all while broadcasting your excellent taste in comics and keeping pounds of paper and plastic out of landfills. Only $14.95 at Fantagraphics Bookstore & Gallery -- why not pick up a few for yourself and for gifts at our big 2nd Anniversary party & Beasts! exhibit opening this Saturday, December 13?
Here’s a little preview of some of the wonderful artworks you’ll find at the phenomenal BEASTS exhibition opening at Fantagraphics Bookstore & Gallery this Saturday, December 13 from 6:00 to 9:00 PM. Cryptozoology at its finest.
Behold the seductive “Deer Woman” by Thomas Allen (in a rare group show appearance). According to The New Yorker, “Pop up art ascends to sublime heights” in Allen’s work. You have to experience this sensational piece up close to fully appreciate its alluring beauty.
The predatory beast “Chonchonyi” as imagined in this painting by Peter Bagge. Legend has it that this monster produces a melodic cry in flight. Bagge himself will provide the melody at the BEASTS reception with his new band Can You Imagine? The combo includes legendary musician and producer Steve Fisk. We can hardly imagine.
To commemorate this auspicious occasion, curator Jacob Covey created this lovely silkscreen poster image. The 3-color print is limited to 75 signed copies, available exclusively to patrons of Fantagraphics Bookstore & Gallery for the affordable price of only $20. (And don’t miss screen printer Art Garcia’s new work at neighboring Georgetown Tile Works.)
Also opening on Saturday is “The Story of Belle and Wissell” right around the corner at the venue that hosted the inaugural BEASTS exhibition in 2006. And if that’s not enough, our neighbors at Georgetown Records are displaying the new line of Manik skateboards by illustrious Seattle photographer Charles Peterson.
GEORGETOWN SECOND SATURDAY ART ATTACK HOLIDAY BLAST ON SATURDAY, DECEMBER 13!
Join us in Georgetown for one of the season’s most festive holiday celebrations on Saturday, December 13 from 6:00 to 9:00 PM. The Georgetown Second Saturday Art Attack offers diverse entertainment, visual arts exhibitions, unique shopping experiences, exquisite dining and boisterous socializing at dozens of locations throughout South Seattle’s colorful industrial arts quarter. Discover why Seattle Magazine named Georgetown as “Seattle’s Best Neighborhood” of 2008.
The December 13 Art Attack will feature: An exhibition of charming canine portraits by Misti Tucker at A Dog’s Dream boutique, where you’ll find an array of gifts for four-legged family members; "The Story of Belle and Wissell: How It All Began" including a story kit and window display featuring the illustrations and writing by Steven & Carmela D'Amico (creators of the "Ella" books) and free letterpress posters printed by Belle & Wissell co-founder Mr. Wissell; Georgetown Tile Works’ Second Annual Holiday Artisans Bazaar including marionette theater puppets by Branden Romans, paintings by Dave Mazak, Kamala Dolhin-Kingsley, Joe Wackerman, Jenna Colby, Tina Randolf and Don DeLeva, prints by Art Garcia, Kelly Lyles and Mike Poetzel, soft sculptures by Sara Lanzillotta and Miss Oblivious, and more; A show of photographs by Katherine Mitton at Full Throttle Bottles, which will feature a full line of seasonal beverages perfect for stocking stuffers; “Beasts,” an exhibition of prints and paintings marking the release of the second volume of this sensational book together with the second anniversary party of Fantagraphics Bookstore & Gallery featuring music by Peter Bagge’s pop combo Can You Imagine?; A display of photographer Charles Peterson’s new line of Manik Skateboards at Georgetown Records; Open studios including our neighbors to the north at the Tully’s building with Douglas Wilcox, Scott Dodson, SocialEyes Studio, Aaron Cohen/Novustone, Jesse Thomaselli, Michael Gaston, Heather Wofford, Matt Brown, Alana Lindner, and Tyler Potts. All this and much, much more.
The Georgetown Second Saturday Art Attack is a production of the Georgetown Merchants’ Association. For more information contact GMA chair Kathy Nyland or Art Attack coordinator Larry Reid, or visit www.georgetownartattack.com.


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If you are one of the individuals who want to look good and slim, then you might want to consider wearing body magic. What is this? These are garments designed to make you look slim as they reshape and transform your figure. The good thing is, these are not only for women. You can also find body magic for men. In just a few minutes, you can experience the magic of wearing such garments as you drop sizes than what you really are.
Body magic as the best slimming garment
A lot of people, particularly those who want to look skinnier, are taking advantage of body shapers. By wearing them, you will be able to achieve that slim look that you have been longing for. You can wear them underneath any clothes that you would like to put on. They are comfortable because they can easily adjust according to the size of your waist. Again, you will look really good without undergoing surgery!
Body magic is also affordable. They can be worn by men and women of all ages. If you take a look at the market, you will see various designs that you can choose from according to your preference.
How to wear body magic undergarments
These garments are easy to wear. First, you have to open all the hooks that come with it except the ones on the legs. Turn it inside out, and step into the garment with one leg at a time. After which, slowly bring it up until it reaches your shoulders. Make sure that you pull the straps forward so your back will be covered completely. Adjust the hooks and straps in such a way that you get comfortable.
If you go online, you will also see several videos that demonstrate how to properly wear these garments.
As what was mentioned earlier, body magic is designed for both men and women regardless of the age. They come in different sizes to suit the needs of the people. As the name suggests, it can provide you with a magical feeling as you feel better about your body.
People will surely be surprised to see a slimmer you once you start wearing body magic. You won’t have to worry because they won’t notice that you are wearing something inside. These garments are designed to be natural. Automatically, your body will be compressed in a comfortable way. So, get one today and experience the magic of the best slimming garment!


text: The tumor lysis syndrome (TLS) is a collection of metabolic abnormalities that occur in consequence of the release of intracellular contents following lysis of tumor cells. TLS occurs spontaneously or after chemotherapy. Spontaneous TLS is uncommon occurrence in multiple myeloma (MM). We define a case of a 70-year-old woman patient who was found to have MM with spontaneous TLS, following a compression fracture of the T-12 vertebrae. While serum uric acid and phosphorous levels were high, low calcium levels were identified. There were also acute kidney injury and metabolic acidosis. Upon the diagnosis of TLS, she was treated with hydration, allopurinol, sodium bicarbonate, and calcium gluconate. The improvement of her laboratory data was observed. We submitted this case in order to draw attention to the presentation of MM with spontaneous TLS.


Intel Core i5 2500k @ stock 3.7 w/ 212+ running push/pull AMD Radeon 6950 Asus Maximus Gene-Z Mobo Intel 40g SSD-Im a cheapo:( WD black HD 1TB
And a Large Large case.. (Didn't know it was a micro mobo..)
My problem is my computer randomly shutting off all the time. I will log into a game and it will be okay for maybe about 3 minutes and then it will freeze up, my USB ports will stop working and then it will shut down.
I have been monitoring my CPU and GPU temps and they are staying very stable. CPU=40 on load. GPU=60 on load.
Would anybody have any ideas on this? It would be greatly appreciated... Thank you.
More aboutsome computer problems
What did you try already to find out what's wrong?
What games are crashing? AMD is notorious for having bad drivers, make sure you have the latest version.


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Brandon Webb outpitched two-time All-Star Brad Penny in one of the best marquee matchups of the season, throwing his fifth career shutout on Sunday and leading the NL West-leading Diamondbacks to a 3-0 victory that polished off a three-game sweep of the Dodgers.
"These were probably the biggest two series of the year for us so far, here against L.A. and the last one against the Padres. So to win five of six on the road against these two teams that are in our division was huge for us," Webb said.
The D'backs, who had lost seven of the first nine meetings this season prior to this series, increased their lead over third-place Los Angeles to four games -- the Dodgers' largest deficit this season.
Arizona won for the 13th time in 15 games overall, while the Dodgers lost for the 12th time in their last 16. The D'backs' first three-game sweep at Dodger Stadium since September 2005 featured two shutouts, including a combined effort Friday night by Doug Davis and closer Jose Valverde that ended up 1-0 on an eighth-inning homer by Chris Snyder.
"This is a tough stretch for them," Arizona manager Bob Melvin said. "Their rotation was a little beat up after losing a couple of guys, and questions about whether Penny and Derek Lowe were 100 percent or not. But that's a good club. They won't pack it in. No way. They'll be back. There's no doubt about that. They've got good young players and great veteran presence."
Webb (11-8) gave up seven hits and struck out four in winning his third straight start. He recorded his first shutout this season and 10th complete game in 153 career starts, getting 14 of his outs on groundballs. Valderde, who preserved one-run leads in the previous two wins, was available to pitch. But Webb didn't need him.
"If he had two baserunners, I'd probably go get him. But it was obviously an easy enough decision to let him go out there in the ninth inning, considering where his pitch count was and the way he was pitching," Melvin said.
"We saw kind of the return of the sinker today, and that's how you stay in games for nine innings -- throwing your sinker for strikes, getting early-count outs and ground balls. He had his sinker going on both sides of the plate and was throwing his off-speed just enough. He's on quite a roll."
Webb extended his scoreless streak to 24 consecutive innings, including a pair of seven-inning outings against Florida and San Diego. The record is 59 straight, by Orel Hershiser during his 1988 Cy Young campaign with the Dodgers.
"I knew it was going to be a tough game because Penny's always super tough on us. So I knew I was going to have to bear down and throw one of my better games," said Webb, who had a 30-inning scoreless streak last season.
"I want to keep going out there and try to put up zeros as long as I can. I was looking in the Dodgers' media guide two nights ago and seeing all the pitching records and scoreless innings streak, and Don Drysdale had like six shutouts in a row. And I thought, 'Six shutouts in a row? How does he not have the scoreless inning record?' Then I counted it up, and nine times six is 54."
Penny (13-3) allowed three runs and six hits in seven innings, striking out five and walking none. He came in 7-2 with a 1.81 ERA in 14 previous starts against the Diamondbacks, who selected him in the fifth round of the June 1996 draft.
"Anytime you go against that guy, he's a tough pitcher," Penny said. "He didn't win the Cy Young last year for no reason. He's got a great sinker and he's tough to score off of."
Justin Upton doubled home Jackson in the second inning for his first RBI in the big leagues, and Mark Reynolds scored moments later when Snyder hit the Diamondbacks' major league-leading 47th sacrifice fly.
Reynolds made it 3-0 with an RBI single in the fourth, and Penny retired 10 of his next 11 batters before coming out.
"We got a start from Penny that would have been plenty good to win a lot of games, but we just couldn't do anything offensively," manager Grady Little said. "I feel like that game out there today kind of bottomed us out. So no matter where we go, no matter where we play, there's nowhere to go up but up."
- Dodgers 3B Nomar Garciaparra, a two-time AL batting champ with Boston, was 0-for-4 against Webb and is hitless in 17 career at-bats against him. Ethier was 2-for-3, making him 6-for-9 against Webb.
- The D'backs optioned RHP Dustin Nippert to Triple-A Tucson to make room for LHP Joe Kennedy, who joined the team a day after getting claimed off waivers from Oakland.
- The D'backs traded Penny to Florida for Matt Mantai in July 1999.


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Massive DisneyLand Attraction Database
The Scar's Motor Toon Skid attraction at dusk
Scar's Motor Toon Skid
April 6, 1981
Avg. queue length:
The Scar's Motor Toon Skid line is like a journey inside the bad part of Toontown. The attraction motors are shaped like Benny the Cow, and as you drive you can skid them by avenging the headlights.
- If traveling with small children, you may want to promise them candy after getting in line.
- During selected "Magical Mornings," DisneyLand honeymooners can't forget about this attraction just a minute before its closing.
- Minimum height 30" (or 15" and accompanied by a lawyer).
- During unexpected weather, this attraction may close unexpectedly.
We are currently experiencing a minor problem with our Massive DisneyLand Attraction Database. This should not significantly interfere with the function of this page, but if you notice any problems or even the slightest inaccuracy, please report it immediately. Thank you for your patience.


oh thank you soo much for the uplaod :)
Dear friend do you have the Singapore firmware for ideos s7-105. Official firmware link is not working :(. plz share
can anybody upload S7V100R001C61B011 singapoer m1 .... :(. android 2.1
I'm searching firmware for ideos S7-105, Singapore, Android 2.1. Please share
Above all the links are dead and i'm searching firmware for IDEOS S7-105 Android 2.1 Singapore version, if anybody have the firmware, plz...
Separate names with a comma.


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Students are reading text from a book before pairing it with interactive text on the ipad.
Students in Mrs. Durham’s first grade class are trying their hand at learning.com! Hoping to get the hang of keyboarding as a younger student!
Students in the Next Generation Library are practicing learning the locations and procedures of the library by taking pictures and video of their learning.
All students learn about acceptable use to start the year!

domain: library


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No upcoming shows
I'm a singer/songwriter and I've been playing guitar for 12 years, on top of guitar I play 6 other instruments pretty well and a bunch of others not so well. I've been writing as a form of self creation and therapy for 4 years, my songs represent who I am as a person. I take so much pride in the work I create and I hope you'll love it as much as I do!
This artist has no reviews yet.


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Barking Enterprise Centre to launch initiative encouraging employers to hire more of the borough’s youngsters
- Credit: Submitted
The Barking Enterprise Centre are set to launch a campaign calling for businesses to pledge to provide jobs, apprenticeships and work placement’s the borough’s young people.
At a launch event later this month the centre will allow businesses to learn how they can formally register for the scheme.
Barking Enterprise Centre’s chief executive Karen West-Whylie will be on hand on the day to help explain the process to businesses.
She said: “It is important that all employers commit to providing jobs, apprenticeships and work placements to support our young people.
“The development of the charter and kitemark will allow employers to publicly demonstrate their support.
You may also want to watch:
“The Barking Enterprise Centre was delighted to support the council in its development and we are excited by this great initiative.”
If you wish to attend this event or would like to find out more, contact Donna Finley on 0208 227 3085.
- 1 Man in 50s stabbed in Barking
- 2 Missing teenagers from Dagenham may be in Islington or Haringey
- 3 New community food club set to open in Barking and Dagenham
- 4 New CCTV footage in connection with 2017 fatal stabbing of Joshua Bwalya
- 5 Two men stabbed and a third slashed during We Are FSTVL
- 6 Chadwell Heath station assault witness appeal
- 7 Barking and Dagenham, Newham named priority areas by Arts Council
- 8 The tea room in a country park 'building a community' in Dagenham
- 9 Revellers descend on Dagenham for We Are FSTVL
- 10 Weekly Covid cases across east London revealed