text:
Saint Paul, Minn. – On November 5th, pro-choice women were elected to critical local offices in sweeping victories across Minnesota — more than 80% of Women Winning’s 34 endorsed candidates were elected to School Boards, City Councils, County Boards, and Mayor’s Offices. Results from two races, which including leading pro-choice women candidates, have yet to be called.
Minnesotans continue to be activated by pro-choice women candidates. Inspiring record voter turnout, record numbers of women were elected to public office in 2018, and the strength of pro-choice women candidates was again reflected in the results of 2019 municipal and school district elections in Minnesota.
Emily Larson, the first woman elected Mayor of Duluth, was re-elected in a decisive victory on the North Shore.
Nicole Joy Frethem won a special election for Ramsey County Commissioner and will be the first woman to represent District 1 on the Ramsey County Board.
With the re-election of Amy Brendmoen, Mitra Jalali Nelson, Rebecca Noecker, and Jane Prince, and results still outstanding in Ward 1 and Ward 6, in Ward 6, the St. Paul continues to lead with a pro-choice woman majority City Council.
Kissy Coakley and Janet Kennedy make history, becoming the first African American women elected to the Minnetonka City Council and Duluth City Council, respectively.
Women Winning is proud of all the inspiring pro-choice women candidates who ran in 2019 and we look forward to their continued leadership.
Voters continue to be energized and inspired by pro-choice women candidates, and Women Winning’s work to elect pro-choice women in 2020 is well underway. With an engaged membership of more than 17,000 Minnesotans committed to changing the face of power, we will elect pro-choice women to all levels of office in 2020 — from Park Board to President of the United States.
The following Women Winning-endorsed candidates were elected in the 2019 General Election.*
Nicole Joy Frethem, Ramsey County, District 1
Emily Larson, Duluth
Amy Brendmoen, St. Paul, Ward 5
Jenna Carter, Bloomington, At-Large
Susan Carter, Minnetonka, At-Large
Kissy Coakley, Minnetonka, Ward 4
Keri Johnson, St. Peter, Ward 1
Janet Kennedy, Duluth, District 5
Nadia Mohamed, St. Louis Park, At-Large
Mitra Jalali Nelson, St. Paul, Ward 4
Rebecca Noecker, St. Paul, Ward 2
Jane Prince, St. Paul, Ward 7
Kimberly Sanberg, Golden Valley, At-Large
Rebecca Schack, Minnetonka, Ward 4
Chauntyll Allen, St. Paul, At-Large
Shannon Andreson, Hopkins, At-Large
Mary Frances Clardy, Inver Grove Heights, At-Large
Zuki Ellis, St. Paul, At-Large
Nicole Hayes, Anoka-Hennepin, District 5
Erin Heers-McArdle, Anoka-Hennepin, District 1
Tanya Khan, Hopkins, At-Large
Jessica Kopp, St. Paul, At-Large
Nelly Korman, Bloomington, At-Large
Mia Olson, Bloomington, At-Large
Katie O’Shea Pederson, Hopkins, At-Large
Alanna Oswald, Duluth, At-Large
Lynne Penke Valdes, St. Anthony, At-Large
Heather Wilsey, St. Louis Park, At-Large
*Election results for St. Paul City Council Ward 1 and Ward 6 are still outstanding. Women Winning endorsed Anika Bowie in Ward 1 and Nelsie Yang in Ward 6.
About Women Winning
Women Winning was established in 1982 by a multi-partisan group of 25 women determined to increase the number of pro-choice women in public office. With more than 17,000 statewide members, Women Winning is Minnesota’s largest women’s political organization.
Women Winning’s mission is to recruit, train, and elect pro-choice women of all political parties to all levels of public office. The organization runs a smart, strategic, and targeted political program focused on competitive districts for pro-choice women candidates with the goal of increasing the number of pro-choice women serving in public office. Women Winning offers robust, formal training, mentorship, and support from the time a pro-choice woman first considers a run for office to election day.

domain: politics


Ronny Deila awaits Celtic's Champions League draw... and could face former club Stromgodset weeks after leaving them
- Champions League first qualifying round draw made on Monday at 11am
- Celtic boss Ronny Deila could face former side Stromgodset over two legs
- Celtic could also play St Patrick's, Cliftonville or The New Saints
- Hoops will play at Murrayfield with Celtic Park being used for Commonwealth Games
Ronny Deila will discover the opponents for his debut as Celtic manager when the first European draws of the season are made by UEFA on Monday.
Celtic will find out what their first hurdle is in the race to make the group stages when the second qualifying round draw is made in Nyon at 11am.
And Norwegian Deila could be up against former club Stromsgodset with Celtic seeded and the Norwegian champions unseeded.
Early start: Ronny Deila's Celtic side must qualify for the Champions League
Other potential opponents include Irish champions St Patrick's and Northern Ireland's representatives, Cliftonville, who lost to Celtic at the same stage last season. Welsh champions The New Saints are also possible foes along with Swedish champions Malmo, who thrashed Hibernian 9-0 on aggregate in the Europa League last season.
Celtic will play their home game at Murrayfield, the home of Scottish rugby in Edinburgh, because their ground is being used for the Commonwealth Games. The second qualifying round starts on July 15-16 with the second legs a week later.
The first qualifying round draw will also take place at the same time and will feature Lincoln Red Imps - the champions of UEFA newcomers Gibraltar.
Dynamic duo: Former Celtic midfielder John Collins was appointed as Deila's assistant this week
The first two rounds of the Europa League qualifiers are also decided with those draws taking place at noon and then 1.30pm.
Aberdeen are among the seeds in the first round, which starts on July 3. Some regionalisation is expected to take place in this draw, which could see the Dons taking on the likes of Belfast-based Crusaders, Derry City, Dundalk, and Welsh sides Airbus UK Broughton and Abersytwyth Town. Linfield, Sligo Rovers and Welsh team Bangor City are also seeded.
Aberdeen and their initial opponents will be unseeded in the second qualifying round draw, alongside William Hill Scottish Cup winners St Johnstone.
Motherwell, who are making their sixth appearance in Europe in seven seasons, are among the seeds. They could meet former European opponents Flamurtari and Mypa 47.
European tour: Derek McInnes' Aberdeen side are among the seeds in the Europa League qualifying round
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Intrauterine growth restriction (IUGR) is associated with accelerated growth and increased adiposity in early life due to unknown mechanisms, which could include increased thyroid hormone (TH) action. We hypothesized that placental restriction (PR) of fetal growth would increase circulating TH concentrations and alter their response to fasting, and that these would relate to growth and body composition in the young lamb. PR reduced size at birth, increased fractional growth rates (FGRs) of soft and skeletal tissues up to 30 days of age, and slowed the ontogenic decrease in plasma total T3 and plasma total T3/T4. PR did not alter the abundance of plasma THs after short-term fasting. In general, plasma total T3 and total T3/T4 ratio correlated negatively, whereas plasma total T4 correlated positively with size at birth. Absolute growth rates of weight and crown-rump length correlated positively with plasma total T3 and total T4 between days 15 and 35. Current FGRs for weight and metatarsal length correlated positively with plasma total T3 between days 20 and 35. In conclusion, PR and small size at birth reduce plasma total T4 and increase plasma total T3 postnatally, whereas catch-up growth relates to increased abundance of the more bioactive forms of TH. Finally, greater soft tissue growth occurs in PR compared with control lambs at the same circulating TH concentrations. This suggests that PR and small size at birth may increase activation of T4 to T3 and sensitivity of soft tissues to TH, which may contribute to catch-up growth following IUGR.
- intrauterine growth restriction
- catch-up growth
- thyroid hormone
children who are born short or light at birth due to intrauterine growth restriction (IUGR) grow at an accelerated rate during infancy (termed “catch-up” growth) (29), but the physiological basis for this is unknown. Clinical IUGR is common, occurring in ∼10% of live births in Australia and up to 40% in some developing countries (45). Most IUGR infants (57–84%) undergo some catch-up growth, which begins as early as 2 wk and is largely complete by 5 mo of age for weight and head circumference and by 6 to 12 mo for height (1, 25, 29, 32, 34). This catch-up growth is associated with a reduced risk of morbidity and mortality in childhood (53) and increases the likelihood of target adult height (25, 29). However, it also predicts increased childhood and adult obesity (46) and may independently add to the risk of developing adult-onset diseases such as diabetes, hypertension, and other cardiovascular disease (12, 16, 19, 42). Understanding the mechanistic basis of catch-up growth after IUGR may clarify whether it could be causally related to later outcomes.
The association of catch-up growth with IUGR suggests that the underlying causes originate in an adverse intrauterine environment, which restricts growth and alters functional development (11, 18, 31), including that of characteristics influencing infant growth, such as appetite and the activity of major neuroendocrine and endocrine axes (13, 17, 21, 49, 55). One such candidate axis is that of hypothalamic-pituitary-thyroid axis (3, 41). Thyroid hormone (TH) acts via T3 and possibly other forms of TH to regulate growth and differentiation of major tissues, as well as fuel metabolism and metabolic efficiency (10, 48, 54). An important element of the hypothalamic-pituitary-thyroid axis and determinant of its activity are circulating levels of TH and the deiodination of T4 to T3, the more biologically active form (27).
Plasma T3 and T4 are reduced at birth in the IUGR infant (6, 28), but plasma T3 subsequently normalizes from 1 wk to 8 mo of age, whereas plasma T4 is reduced up to 2 mo of age before normalizing (28). This suggests that following IUGR, there may be normal TH production, but enhanced conversion of T4 to T3, which helps maintain TH bioavailability and action (28). Although the smaller IUGR infants in this study gained as much weight as normal infants over the period of study, suggestive of catch-up growth, the associations with circulating T3 or T4, were not assessed (28). It is therefore possible that in those infants undergoing catch-up, the conversion of T4 to T3 and plasma T3 levels are highest (28).
Limited data from other species also suggest a role for TH action in catch-up growth. In lambs with spontaneous fetal growth restriction and fed artificially, plasma T3 and T4 several hours after birth and plasma T3 at 11 days, correlated positively with birth weight, while plasma T3 after birth also correlated positively with subsequent weight gain during the first month of life (7). Whether plasma concentrations of THs beyond the first day of life are also related to size at birth, and subsequent postnatal growth in lambs with fetal growth restriction was not determined, however (7).
A major cause of IUGR is placental insufficiency, which reduces delivery of oxygen and nutrients to the fetus (reviewed in Ref. 38). We have shown that experimental restriction of placental and, hence, fetal growth in sheep and other species has similar growth, metabolic, and endocrine consequences for the fetus, to human IUGR (40). We have also recently shown that placental restriction reduces size at birth and increases postnatal growth in the first month of life in sheep (20). Placental restriction in sheep decreases plasma total T4 levels in the lamb in the first 24 h after birth (35), but whether plasma T3 is also altered and whether such changes persist and contribute to altered growth restriction is unknown. We therefore hypothesized that placental restriction (PR) of fetal growth in sheep would increase circulating TH concentrations and that these would relate to growth and body composition in the young lamb in the first month of life. Short-term fasting inhibits activation of T4 to T3 and reduces plasma total or free T3 in rats and humans in adaptation to fuel shortage (26, 30). We therefore hypothesized that the greater growth rate of PR lambs might be partially due to reduced responses of THs to fasting, such that TH levels and activity would be maintained to a greater extent between feeds in placentally restricted lambs compared with control lambs.
MATERIALS AND METHODS
Animals and Surgery.
All procedures were approved by the University of Adelaide Animal Ethics Committee (Animal Ethics Approval Number: M/1/97A). Placental growth was restricted (PR) in 45 Merino ewes by removal of the majority of visible endometrial caruncles (65–148) from the nonpregnant uterus (43). Six to ten caruncles were left in each horn of the bicornuate uterus. This reduces the number of placentomes formed in the subsequent pregnancy and hence placental size and function (39). Surgery was performed under aseptic conditions, and general anesthesia was induced by intravenous injection (9.9–14 mg/kg) of pentothal (Rhone Merieux, Australia), and maintained with halothane inhalation anesthetic (Zeneca Limited Australia) in oxygen. Postsurgery, all ewes received a 3-day course of intramuscular antibiotics (2 ml) (Ilium Penstrep-Troy Laboratories, Smithfield, New South Wales, Australia). After a 6-wk recovery period, the ewes entered a mating program, and pregnancies were confirmed by ultrasound. Ewes were housed in individual pens in animal holding rooms from approximately a week before giving birth, with a 12:12-h light-dark cycle, and fed lucerne chaff twice daily ad libitum, with water ad libitum. The control and placentally restricted ewes delivered 35 singleton lambs, of which 18 lambs were from control ewes, and 17 lambs were from the placentally restricted ewes (PR lambs). Placentae were collected and weighed ∼2 h after natural delivery to avoid disturbing neonatal and maternal behavior, and these data are only included where the placenta was intact. Lambs were housed in the pens with their mothers throughout the study. At 4 to 5 days of age postnatally, catheters were inserted into the femoral artery and vein under general anesthesia of halothane inhalation anesthetic and aseptic techniques. All lambs received an intramuscular injection (2 ml) of antibiotics (Ilium Penstrep-Troy Laboratories) before surgery and then for 3 days postsurgery. Patency of the catheters in the lambs was maintained by filling the catheters with heparinized saline (500 U/ml) daily for 3 days and then every second day.
Body weight and various parameters of size were measured at birth and subsequently every 5 days up to 45 days of age. The following parameters were measured to characterize growth: total body weight (soft tissue and skeletal tissue growth), crown-rump length (CRL; vertebral column growth), shoulder height, tibia and metatarsal lengths, and abdominal circumference (liver and gut). Body mass index was calculated as weight/CRL2 (kg/m2), and ponderal index was calculated as weight/CRL3 (kg/m3). The absolute growth rate (AGR) of each lamb was determined by linear regression analysis of a parameter vs. postnatal age from 0–45 days to obtain the slope of the line of best fit. Neonatal fractional growth rate (FGR) was calculated as the AGR for the period of growth (0–45 days) divided by the value of the parameter at birth. Current FGRs at each age (current FGR) were calculated as the absolute growth rate for the period of growth (0–45 days) divided by the value of the parameter at that age. FGRs better reflect the anabolic effort that the individual lamb is exerting for growth, as it indicates the amount of tissue gained relative to the size of that lamb and the tissues producing that growth. Furthermore, an increased fractional growth rate indicates catch-up growth. Neonatal and current FGRs for all parameters of growth at various ages were correlated with plasma total T3 and T4 concentrations at the corresponding ages. At 43 ± 2 days of age, a subset of the lambs (nine controls and nine PR) was killed by intravenous administration of an overdose of barbiturate (pentobarbital sodium, Lethabarb). The fat depots that could be completely dissected were weighed (retroperitoneal, perirenal, and omental fat depots). Visceral fat weight was calculated as the sum of these three fat depots. Relative visceral fat weight was calculated as a proportion of body weight.
Plasma THs (Free and total T3 and T4).
Fasted arterial blood samples were taken at 30 days of age, and plasma was removed for determination of TH concentrations in 18 control and 17 PR lambs. In a subset of these animals (9 control: 5 male, 4 female; 9 PR: 4 male, 5 female), additional fed (days 5, 15, 20, 35, 40, 45) and fasted (day 8) arterial blood samples were collected for determination of plasma TH concentrations. Fed samples at day 5 were collected ∼24 h postsurgery. Before collection of fasting samples, lambs were fasted for 3 h by placing them into a pen beside the mother to prevent suckling and to minimize stress. Free T3 and T4 (FT3, FT4), and total T3 and T4 (TT3, TT4) were determined in plasma by specific radioimmunoassay (RIA-gnost FT3, FT4, TT3, TT4 CIS bio International, France). The detection limits for the assays of FT4 and TT4 were 0.5 pg/ml and 2.5 ng/ml, respectively, whereas the detection limits for FT3 and TT3 were 2.0–4.25 pg/ml and 0.1 ng/ml, respectively. The intra-assay coefficients of variation for FT3, TT3, FT4, and TT4 were 1.9%, 1.6%, 5.4%, and 6.2%, respectively.
Data were analyzed using the SPSS 13.0 software package for Windows. Two-way ANOVA was used to test for effects of gender and interactions with PR. Where gender effects were not significant, the effect of PR on parameters was subsequently assessed by 1-way ANOVA. The effect of PR on TH concentrations in fed plasma was analyzed using repeated-measures ANOVA (six levels). Comparisons between control and PR lambs at each age were made by using 1-way ANOVA. Associations between parameters were assessed by Pearson correlation or multiple linear regression analysis. Statistical significance was assumed at P < 0.05, and data are expressed as means ± SE.
Effect of PR on size at birth and postnatal growth.
PR reduced placental weight (−39%) and size at birth, with greater reductions in soft tissues: weight (−23%), CRL (−7%), abdominal circumference (−10%), shoulder height (−7%), tibia (−7%), and metatarsal lengths (−5%), with reduced body mass index (−12%), and relative sparing of head width (−5%) (P < 0.05 for all) (Table 1). PR did not alter AGRs (data not shown) but increased neonatal FGRs (AGR relative to size at birth) for weight (+24%), tibia (+15%), and metatarsal (+18%) lengths, hindlimb (+23%), and abdominal circumferences (+19%) between birth and 45 days (P < 0.05 for all). PR also increased current FGRs for weight (days 5 to 30), crown-rump length (days 5 to 30), abdominal circumference (days 5 to 25), and metatarsal length (days 5 to 15 and day 25) (P < 0.05 for all) (Fig. 1). Body weight before postmortem tended to be higher in male than female lambs (P = 0.06), but it did not differ between control and PR lambs (control male: 21.4 ± 0.7 kg, PR male: 20.2 ± 0.8 kg, control female: 16.3 ± 0.8 kg, PR female 16.0 ± 0.7 kg, P = 0.33). PR increased absolute perirenal fat mass (control: 92.8 ± 13.9 g, PR: 133.3 ± 10.7 g, P = 0.035) and relative perirenal fat mass (control: 0.54 ± 0.04%, PR: 0.74 ± 0.06%, P = 0.022). PR tended to increase absolute visceral fat mass (control: 309.6 ± 36.6 g, PR: 406.8 ± 38.5 g, P = 0.086), and increased relative visceral fat mass (control: 1.64 ± 0.18%, PR: 2.24 ± 0.21%, P = 0.04).
Effect of PR on circulating TH in the fed state.
In the fed state (days 5 to 40), plasma total T4 did not change with age and was not altered by PR (Fig. 2). Plasma total T3 decreased with age (P < 0.0001) and was reduced at days 35 and 40 compared with that at day 5 in the fed state (P < 0.05 for both) (Fig. 2). In the fed state, PR did not alter plasma total T3 overall (Fig. 2). Plasma total T3/T4 ratio declined with age (P < 0.0001) and was reduced at days 20, 25, 35, and 40 compared with that at day 5 in the fed state (P < 0.05 for all) (Fig. 2). PR did not alter the plasma total T3/T4 ratio overall but increased plasma total T3/T4 ratio at day 20 (P < 0.05) in the fed state (Fig. 2). There were no differences between males and females in plasma total T3 and T4 concentrations or the total T3/T4 ratio in the fed state nor did any interactions between sex, PR, and age influence these parameters (data not shown).
Effect of PR on the circulating TH response to fasting.
Plasma total T3 and T4 concentrations and the ratio of T3 to T4 on days 8 and 30 after short-term fasting did not differ between PR and control lambs (P > 0.05 for all, Fig. 2).
PR did not alter plasma-free T3 (control: 9.7 ± 0.3 pmol/l; PR 10.0 ± 0.4 pmol/l) or T4 (control: 21.7 ± 1.4 pmol/l; PR 23.7 ± 1.4 pmol/l) concentrations and the free T3/T4 (control: 0.35 ± 0.16; PR 0.36 ± 0.18), free T3/total T3 (control: 6.5 ± 0.4; PR 6.8 ± 0.3), and free T4/total T4 (control: 0.31 ± 0.02; PR 0.29 ± 0.02) ratio at 30 days of age. There were no differences between males and females in plasma-free and total T3 and T4 concentrations or free and total T3/T4 ratios in the fasted state, nor were there significant interactions between sex and PR (data not shown).
Associations between circulating THs and size at birth in the fed and fasted state.
In control lambs, plasma total T4 concentrations in the fed state throughout the study did not correlate with size at birth (Fig. 3), whereas those in the fasted state at days 8 and 30 correlated positively with size at birth in terms of weight, CRL, and shoulder height (Fig. 3) and tibia and metatarsal lengths (data not shown). Similarly, in PR lambs, plasma total T4 concentrations in the fed state generally did not correlate with size at birth (Fig. 3), whereas those in the fasted state at day 8 correlated positively with size at birth in terms of CRL and shoulder height (Fig. 3).
In control lambs, plasma total T3 concentrations in the fed state during the first month of life (days 5, 15, 25) usually correlated negatively with size at birth, in terms of weight, CRL, shoulder height (Fig. 3), and metatarsal length (data not shown). In PR lambs, plasma total T3 in the fed state during the first month of life also correlated negatively with size at birth, in terms of weight, CRL, and shoulder height (Fig. 3), as well as metatarsal and tibia lengths (data not shown) but predominantly at days 15, 20, and 25 (Fig. 3). In the fasted state, plasma T3 concentrations during the first month of life did not correlate with size at birth in either control or PR lambs, except for PR lambs at day 8, in which T3 concentration was positively related to shoulder height at birth (Fig. 3).
In control lambs, the plasma total T3/T4 ratio in the fed state during the first month of life did not correlate with size at birth (data not shown). In PR lambs, the plasma total T3/T4 ratio in the fed state during the first month of life (days 5 and 25) correlated negatively with size at birth in terms of weight (r = −0.91, n = 4, P < 0.05; r = −0.69, n = 8, P < 0.05), CRL (r = −0.92, n = 4, P < 0.05; r = −0.74, n = 8, P < 0.05), metatarsal (r = −0.91, n = 4, P < 0.05; r = −0.64, n = 8, P < 0.05) and radius/ulna length (r = −0.97, n = 4, P < 0.05; r = −0.73, n = 8, P < 0.05), skull length (r = −0.88, n = 4, P < 0.05; r = −0.71, n = 8, P < 0.05), abdominal (r = −0.91, n = 4, P < 0.05; r = −0.66, n = 8, P < 0.05) and thoracic circumference (r = −0.92, n = 4, P < 0.05; r = −0.82, n = 8, P < 0.05). In control or PR lambs, plasma total T3/T4 ratios in the fasted state at days 8 and 30 did not correlate with any measure of size at birth (data not shown). Free T3 and free T4 concentrations in the fasted state at 30 days of age were not related to size at birth. In all lambs, plasma-free T3 to free T4 ratio correlated positively with size at birth for abdominal circumference (r = 0.29, n = 34, P = 0.03) and negatively with placental weight (r = −0.49, n = 34, P = 0.02). In control lambs, plasma-free T3 to free T4 ratio correlated positively with size at birth for weight (r = 0.36, n = 22, P = 0.05), abdominal (r = 0.45, n = 22, P = 0.02), and thoracic (r = 0.44, n = 22, P = 0.02) circumferences. Plasma-free T3 to free T4 ratio did not correlate with size at birth in PR lambs.
Associations between circulating THs and postnatal growth in the fed and fasted state.
AGR for all lambs in terms of weight correlated positively with plasma total T3 concentrations in fed lambs at day 35 (r = 0.39), and plasma total T4 concentrations at days 30 (fasted; r = 0.37), 35 (fed; r = 0.48), and 40 (fed; r = 0.45) (P < 0.05 for all). AGR for all lambs in terms of CRL correlated positively with plasma total T3 concentrations in fed lambs at days 15 (r = 0.48), 20 (r = 0.51), and 35 (r = 0.42), and plasma total T4 concentrations in fed lambs at day 20 (r = 0.64) (P < 0.05 for all).
In PR lambs, AGR in terms of tibia length correlated positively with plasma total T3 concentrations in fed lambs at day 35 (r = 0.75, n = 9, P < 0.05). In PR lambs, absolute growth rate in terms of abdominal circumference correlated positively with plasma total T3 and T4 concentrations in the fasted state at day 8 (r = 0.76, n = 8, P < 0.05, for both) and with that of T3 at day 30 (r = 0.60, n = 9, P < 0.05).
Neonatal FGRs did not correlate with plasma total T4 concentrations during the first month of life in either control or PR lambs in the fed or fasted states (data not shown). In control and PR lambs, neonatal FGR in terms of weight correlated positively with plasma-free T4 concentrations in fasted lambs at day 30 (controls r = 0.43, P < 0.05, PR r = 0.46, P < 0.05) (Fig. 4).
In control and PR lambs, neonatal FGRs for weight (control: r = 0.92, P = 0.0005; PR: r = 0.80, P = 0.025) and CRL (control: r = 0.88, P = 0.0005; PR: r = 0.67, P = 0.05) correlated positively with plasma total T3 in fed lambs at day 15 (Fig. 5). In PR, but not control lambs, neonatal FGR in terms of weight correlated positively with plasma total and free T3 concentrations in fasted lambs at day 30 (controls r = 0.23, NS, PR r = 0.57, P < 0.05; controls r = 0.23, NS, PR r = 0.57, P < 0.05, respectively) (Fig. 4).
Current FGR for any parameters of size generally did not correlate with plasma total T4 in either control or PR lambs in the fed or fasted states throughout the first month of life (data not shown). However, in PR lambs in the fed state at day 20, current FGR for CRL correlated positively with plasma total T4 (r = 0.92, n = 7, P < 0.005), whereas current FGR for metatarsal length correlated positively with plasma total T4 (r = 0.66, n = 7, P < 0.05) (Fig. 6).
In control lambs, current FGR for weight correlated positively with plasma total T3 concentrations in fed lambs at days 15 (r = 0.61, n = 9, P < 0.05), 25 (r = 0.63, n = 9, P < 0.05), 35 (r = 0.69, n = 9, P < 0.05), and 40 (r = 0.81, n = 9, P < 0.05) (Fig. 6). Similarly, in control lambs, current FGR for CRL correlated positively with plasma total T3 concentrations in fed lambs at day 5 (r = 0.69, n = 8, P < 0.05), 15 (r = 0.78, n = 9, P < 0.05), and 25 (r = 0.75, n = 9, P < 0.05) (Fig. 6). In control lambs, current FGR for metatarsal length (control: r = 0.66, P = 0.05; PR: r = 0.15, NS) correlated positively with plasma total T3 concentrations in fed lambs at day 15 (Fig. 6).
In PR lambs, current FGR for weight correlated positively with plasma total T3 concentrations in fed lambs at day 15, but negatively with plasma total T3 concentrations in fed lambs at day 40 (Fig. 6). In PR lambs, current FGR for CRL correlated positively with plasma total T3 concentrations in fed lambs at day 20 (r = 0.69, n = 7, P < 0.05) (Fig. 6). Similarly, in PR lambs, current FGRs for metatarsal length correlated positively with plasma total T3 concentrations in fed lambs at day 15 (r = 0.42) and 25 (r = 0.44) (P < 0.05 for all). In PR lambs, current FGRs for tibia length correlated positively with plasma total T3 in fed lambs at day 35 (r = 0.74, n = 7, P < 0.05) (Fig. 6).
This study has shown that in the first month of life in sheep, PR alters TH abundance, between 15 and 25 days of age during the period of catch-up growth. Previous studies showed that, plasma T3 and T4 were reduced by IUGR in the first day of life in sheep (7, 28), which we now show does not persist. Rather, there is normal plasma T4, increased plasma T3 and an increased ratio of plasma T3 to T4 in early postnatal life after IUGR, possibly due to increased TH activation. Because this increase in circulating T3 is of delayed onset, between 15 and 25 days of life, which is mostly after the period of maximal catch-up growth, it may not have a primary role in the earliest onset catch-up growth. However, subsequent catch-up growth throughout the first month of life is correlated with and may partly depend on circulating total or free T3 and free T4. Because we measured free T3 and free T4 using assays designed for human plasma, because of the lack of assays validated for the sheep, it is possible that not all interference from circulating TH binding proteins was removed. Nevertheless, the correlations between growth rate and free TH concentrations in the present study suggest that this did provide a good measure of bioactive TH.
Plasma T3 and the ratio of plasma total T3 to T4 increase in the first 8 h of life in the sheep and other species (3, 7, 28), reflecting, in part, an increase in TSH, which stimulates T4 and T3 secretion from the thyroid, as well as the loss of the placenta with its high deiodinase type III (DIII) activity, which inactivates T3 and T4 (4). Subsequently, in sheep, plasma T3 and the ratio of plasma T3 to T4 increase to a maximum at 1 to 2 wk of age and then decline (7). Our current findings are consistent with this ontogeny, as plasma T4 did not change, whereas plasma T3 and the ratio of total T3 to T4 were maximal in samples collected between 5 and 15 days of age, then decreased subsequently in the young lamb. A broadly similar pattern occurs in the human infant, in which serum-free and total T3 increase to maximal levels at 50 to 80 days of age before decreasing (28). These changes in circulating TH levels and the relative amounts of T3 and T4 presumably reflect the secretion of T4 and T3 by the thyroid under TSH stimulation, and the production of T3 in extrathyroidal tissues (28). The relative abundance of different forms of TH is regulated by 5′ deiodination catalyzed by deiodinase type I (DI) and type II (DII), with the former, in particular contributing to circulating T3 (reviewed in Ref. 4). Together with DIII, these selenodeiodinases also inactivate T3 and T4 and help determine their levels in blood (reviewed in Ref. 4). We still know little of how these particular determinants of T4 and T3 activation and inactivation change and are regulated during development in sheep or humans, but an adverse prenatal environment, which restricts fetal growth, may persistently affect these and hence peripheral THs.
Although plasma total T4 levels in the young lamb in the fed state were unaffected by placental restriction or size at birth, they did decrease with size at birth in the fasted state. In lambs exhibiting spontaneous fetal growth restriction, plasma total T4 and T3 levels in the first few hours of life and at 11 days of age are reduced and correlate positively with birth weight and with subsequent postnatal growth in terms of weight, during the first month of life (7). Therefore, a mild deficit in circulating T4 may persist for several weeks after significant IUGR, because of reduced production or increased activation and metabolism. Our findings provide support for the latter mechanism, as plasma T3 increased with decreasing size at birth at various ages in control and/or placentally restricted lambs, implying that being small at birth enhances activation of T4 to T3. Also, consistent with increased activation of T4 to T3 after fetal growth restriction, we observed an increased plasma T3/T4 ratio with decreasing size at birth in PR lambs during the first month of life. In the human IUGR infant, serum total T4 is reduced and serum total T3 increases in the first 2 mo of life, suggesting an increased total T3 to T4 ratio, which resembles the pattern observed here and in previous studies of experimental and spontaneous IUGR in the neonatal sheep (28). It may be that in the young lamb and human infant, restriction of fetal growth increases deiodinase activity, contributing to the observed increases in plasma T3 and the plasma T3 to T4 ratio.
Placental restriction alters the metabolic environment and endocrine state of the fetus, but the particular changes and factors that initiate programming of altered production and activation of TH postnatally and the mechanisms responsible are unknown (4). In the rat, induction of perinatal hypothyroidism in mothers and their offspring alters the hypothalamic-pituitary-thyroid axis, producing hypothyroidism in offspring, which persists into adult life, with reduced plasma T4 and T3, despite normal plasma TSH (41). In contrast, perinatal hypothyroidism in the pig increases plasma total and free T3 during the first day of life, but whether this persists was not determined (3). As PR in the sheep also causes fetal hypothyroidism (23, 38, 39), this endocrine perturbation may alter TH production and activation postnatally, as occurs in these other species, albeit by unknown mechanisms. Other neuroendocrine consequences of PR could also contribute to enhanced activation of TH in the young lamb. Factors known to promote DI activity and/or activation of T4 to T3 include T3 itself, growth hormone (GH), and glucocorticoids, which have effects that appear to vary with developmental stage (14, 51, 52). In humans, low birth weight is characterized by signs of GH resistance and increased glucocorticoid activity in postnatal life (9, 33), which would promote TH activation. Similarly, we have previously shown that the male PR sheep is GH resistant, while the females are GH deficient (20). Spontaneous IUGR in sheep is characterized by increased circulating cortisol in the first 48 h of life, although whether this persists is unclear (7).
In the current study, postnatal growth in the first month of life was related to circulating TH abundance, particularly after 15 days of age in the young lamb, consistent with the requirement of neonatal growth for TH (8, 15, 54, 56). FGRs for soft and skeletal tissues were predicted by plasma-free T4 and free and total T3, but not plasma total T4, suggesting that they are driven in part by the more biologically active forms of TH (27). Interestingly, for catch-up growth in terms of weight, a higher rate of neonatal or current fractional growth was seen at a given plasma concentration of TH in the PR lambs compared with the control lambs. One possibility is that the PR lambs are more “sensitive” than normal to growth-promoting actions of TH actions, which could be brought about by increased tissue expression of TH receptors (THRs) or increased activation of T4 via altered expression of deiodinases (4, 48). Certainly, increased expression of THRs in skeletal muscle has been observed in the very young pig in response to experimentally induced postnatal hypothyroidism (24). Whether any of these changes occur in other tissues and persist and impact on growth is unclear (24). Increased T3 abundance may also contribute to the altered body composition of the PR lamb, which had increased visceral adiposity at 1 mo of age. The twin or triplet neonatal lamb that has experienced fetal growth restriction is also relatively fat compared with singleton lambs at any given body weight (2, 22). Furthermore, in humans, low birth weight predicts reduced skeletal tissue or lean tissue mass (46) and increased relative central adiposity in later life (37). This suggests a greater proportion of tissue accretion in adipose tissue in early postnatal life following IUGR; in which increased T3 production and action may have a role, as this promotes differentiation of preadipocytes into adipocytes and the accumulation of triglyceride (47).
Although there were consistently higher rates of neonatal and current FGRs for weight in PR lambs, at any given plasma TH concentration, this was not the case for growth of skeletal tissues. This implies that the sensitivity of skeletal tissue growth to THs did not differ between control and PR lambs and suggests that the primary determinant of increased growth of long bones or the vertebral column in the young PR lamb, is increased abundance of free T3 and T4 and of total T3 in circulation, rather than any changes in determinants of local TH action in the growth plate and elsewhere within skeletal tissues (44). Increased abundance and action of THs may also influence postnatal growth after IUGR indirectly, by promoting synthesis and secretion of insulin-like growth factor-I (5) or by inhibiting the activity of 11β-hydroxysteroid dehydrogenase-1 and local production of cortisol from cortisone and hence its inhibitory actions on growth (8, 36, 50).
In conclusion, placental restriction in the sheep reduced size at birth and increased postnatal growth rates in terms of weight and long bones in lambs. Plasma TH was associated with absolute and fractional growth of soft and skeletal tissue in lambs during early postnatal life, particularly in those undergoing catch-up growth. Thyroid hormone has long been known to be essential for infant growth, and this study has now shown that the increased rates of growth seen in postnatal life after IUGR may be partly due to the increased abundance of TH and possibly increased sensitivity of tissues to TH.
We thank Dr. Tim Butler, Anne Jurisevic, and Dr Michael Adams for technical assistance with surgery. This project was funded by the National Health and Medical Research Council of Australia.
The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
- Copyright © 2006 the American Physiological Society

domain: literature


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Join WKLS program coordinator Professor Carlo Fanelli and others on January 23 to help celebrate their books published this past year. Light refreshments will be served. More information at this link.
Work and Labour Studies Students are invited to come out to form this year's Work and Labour Studies Student Association (WLSSA). We will be meeting on Monday, November 4 at 13:00 in North Ross 829. The meeting will run for approximately 30-45 mins. The purpose of the meeting is to elect students to serve on […]
The Global Labour Speaker Series welcomes one and all to their latest book launch on Wednesday, October 23 from 16:30-18:30 at Kaneff Tower 519. Links to the event poster and Eventbrite registration.
Prof. Carlo Fanelli: Leaders Serious About Tackling Low-Wage Work Should Embrace Unions (Huffington Post)
Read Carlo Fanelli's Huffington Post op-ed "Leaders Serious About Tackling Low-Wage Work Should Embrace Unions".
Prof. Carlo Fanelli: Lower Wages, Less Job Security: More Than 2 Million Canadians Worked in Temporary Jobs Last Year (Press Progress)
‘This inequality is not accidental’: Canadian workers stuck in temporary jobs earn $6 per hour less than permanent workers. More than one-in-eight Canadian employees worked a temporary job in 2018, earning on average $6 per hour less than those working permanent jobs. According to a report by Statistics Canada, published Tuesday, the percentage of Canadian workers […]
Prof. Carlo Fanelli: The Ford government’s punishing first budget aligns with the global trend of authoritarian right-wing populism. It’s more like ‘permanent austerity.’ (Policy Options)
So much for ‘austerity-light’ in Ontario - The Ford government’s punishing first budget aligns with the global trend of authoritarian right-wing populism. It’s more like ‘permanent austerity.’ One eminent conservative scholar of public budgeting characterized annual budgets as a record of “victories, defeats, bargains and compromises.” Ontario’s 2019 Budget, the first of the new Conservative government of […]
Prof. Carlo Fanelli's new book is The Public Sector in an Age of Austerity: Perspectives from Canada’s Provinces and Territories
On January 17 the Department of Social Science held its 2nd Annual Book Celebration for the department's authors - including Work & Labour Studies' program coordinator Carlo Fanelli for his book The Public Sector in an Age of Austerity: Perspectives from Canada’s Provinces and Territories (McGill-Queen’s University Press). Read the Yfile story for more information.

domain: news


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After an exceptionally long gap between posts, Sci-Fi-O-Rama finally returns with new material. Apologies for the extended state of dormancy, life gets in the way sometimes.
Let’s then not dwell on the forlorn and instead nuke 2015 with another flyby of master-craftsman and styrene alchemist Grant Louden AKA Betelgeuse.
Welcome to Sci-Fi-O-Rama 2014.
Here we begin with a totally exclusive feature courtesy of both Grant Louden & Dan McPharlin.
So without ado lets hand over the controls to Dan…
70’s Sci-Fi Art by Angus Mckie as featured in Paper Tiger’s ‘The Flight of Icarus’ – originally used in Stewart Cowley‘s Terran Trade Authority series of illustrated books.
Angus Mckie home site: http://www.apbh75.dsl.pipex.com/
Retro 70’s Sci-Fi painting by Bob Layzell, more from Terran Trade Authority series (1978 – 1980) ?.
Art sourced (pinched!) via the excellent Ski-ffy Blog, more examples of Bob’s work here: http://ski-ffy.blogspot.com/2008/04/bob-layzell.html

domain: artistic


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Session Type: ACR Poster Session A
Session Time: 9:00AM-11:00AM
Background/Purpose: The use of Rituximab (RTX) in patients with autoimmune diseases has been associated with an increased incidence of infection and risk factors for this complication are not well established. The aim of our study was to compare the incidence of infections and its related factors in the first six months after RTX infusion in two rheumatic diseases: systemic lupus erythematosus (SLE) and inflammatory myopathies (IM).
Methods: From August 2009 to March 2015, a total of 48 SLE and 39 IM consecutive patients were longitudinally followed in the biologic therapy center of Rheumatology Division of a tertiary university hospital using a standardized electronic database protocol including demographic data, clinical and laboratorial findings and treatment. RTX is regularly administered in our center with infectious screening and the protocol consisted of either 4 weekly doses of 375mg/m2 or two doses of 1g (day 0 and 14). IM standard treatment also included the recommendation of IVIG 2-4 weeks pre RTX infusion, whereas IVIG was only indicated for lupus for severe refractory activity. Severe infection was defined as episode that required the use of intravenous antibiotics or hospitalization.
Results: SLE patients presented a significant higher incidence of overall (50.0 vs. 7.7%, p<0.001) and severe (22.9 vs. 0%, p<0.001) infections than IM patients in the first 6 months after RTX infusion. SLE and IM patients had similar age (38.0±13.3 vs. 41.5±13.2, p=0.230) and frequency of female gender (93.8 vs. 82.1%, p=0.105). At baseline, both groups had similar mean IgG level (1168.8±527.0 vs. 1346.3±397.0 mg/dL, p=0.087). With regard to treatment, mean prednisone dose (32.0±21.1 vs. 22.3±15.4mg/day, p= 0.018) was higher in SLE but the frequency of patients with associated immunosuppressants was lower in SLE (79.2 vs. 97.4%, p=0.020). IVIG infusion (2g/Kg) before RTX infusion was less often used in SLE than in IM patients (14.6 vs.69.2%, P<0.001). Previous history of severe infection 6 months before RTX was alike in SLE and IM (10.4 vs. 2.6%, p=0.218). Further analysis of 11 severe infection episodes revealed that they only occurred in SLE, more than half (64%) were sepsis and they were observed at a mean of 3.6 months (range 1 – 5 months) post infusion. At baseline, these patients were under a mean prednisone dose of 41.4±30.2mg/day and their mean IgG level was 1361.5±753.1 mg/dL.
Conclusion: We observed that SLE was associated with an unexpected higher incidence of overall and severe infections than IM patients in spite of adequate and comparable baseline IgG levels. Risk factors identified were high glucocorticoid dose and less use of pre-RTX IVIG infusion. Further studies are necessary to determine if the recommendation of IVIG pre-RTX treatment will reduce severe early infection in SLE.
To cite this abstract in AMA style:Medeiros C, Seguro L, de Souza FHC, Aikawa NE, Bonfa E. Risk Factors for Severe Infections in Rituximab Treated Patients: Comparison of Systemic Lupus Erythematosus and Inflammatory Myositis [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/risk-factors-for-severe-infections-in-rituximab-treated-patients-comparison-of-systemic-lupus-erythematosus-and-inflammatory-myositis/. Accessed November 29, 2020.
« Back to 2016 ACR/ARHP Annual Meeting
ACR Meeting Abstracts - https://acrabstracts.org/abstract/risk-factors-for-severe-infections-in-rituximab-treated-patients-comparison-of-systemic-lupus-erythematosus-and-inflammatory-myositis/

domain: medical


21.09.2012 [FanIQ (blog)] - The fight for the mouthwatering $10 million bonus from the FedEx Cup Series has turned into a raging battle between teammates. Everyone anticipated the emergence of a prominent leader after yesterday's first round of the Tour Championship at East Lake
23.09.2012 [FOXSports.com] - ATLANTA. The drive was, in Tiger Woods' own words, “a bad, bad tee shot.” Golf. TOUR CHAMPIONSHIP. Snedeker win FedEx Cup title · Scores | Photos · Final FedEx Cup standings · Hole-by-hole recap · 5 things from Atlanta. Woods had just come off a
21.09.2012 [USA TODAY (blog)] - It doesn't take much for most of us to jump on the Tiger Woods bandwagon. A first round 66 will easily do. Woods, tied for the lead in the Tour Championship, is now the 7-4 favorite to win the tournament and the FedEx Championship. Here are the updated
24.09.2012 [ESPN] - ATLANTA -- In the five previous years of the FedEx Cup playoffs, surgery or a combination of injury/poor play kept Tiger Woods from the finale in Atlanta three times. But on the two occasions he did get to East Lake, Woods walked away with the FedEx
23.09.2012 [Newsday] - Ditto for Tiger Woods, four shots behind. The Tour Championship has never had so much at stake for so many top players. "It's going to be one of the most exciting Sundays of the year," McIlroy said after a 68. "Great to be in the mix." McIlroy, who won
23.09.2012 [Newser] - And he won $10 million for capturing the FedEx Cup, which comes with a 5-year exemption on the PGA Tour. He closed with a 2-under 68 to finish at 10 under, three strokes ahead of Justin Rose. McIlroy and Tiger Woods, both of whom could have won the
22.09.2012 [El Mensajero] - Redacción deportes.- El estadounidense Jim Furyk tomó el relevo al frente del The Tour Championship de golf, último torneo de la FedEx Cup y en el que toman parte los 30 mejores jugadores del circuito estadounidense, de su compatriota Tiger Woods
22.09.2012 [New York Daily News] - All he cares about is winning the Tour Championship, with an outside shot at the FedEx Cup title and its $10 million bonus. Furyk was at 7-under 133 on a course where he won just two years ago. Rose, who shared the 18-hole lead with Tiger Woods, made
20.09.2012 [ESPN (blog)] - Each of the top five players in the standings entering this week (Rory McIlroy, Tiger Woods, Nick Watney, Phil Mickelson, Brandt Snedeker) controls his own destiny. Any of those players will automatically win the FedExCup with a victory this week.
20.09.2013 - Yahoo! SportsTiger Woods shoots 66, surges up leaderboard at BMW ChampionshipCBSSports.comTiger Woods shot a 66 on […] Saturday, will need to go even lower on Sunday Tiger Woods shoots a 66 on Saturday and will need to go even lower on Sunday […] . (USATSI). More Golf: Leaderboard | Rankings | Schedule | Expert Picks | Equipment | FedEx Cup.BMW Championship Tiger Woods
03.01.2014 - participation by the best players. For several years Tiger Woods and Phil Mickelson have not bothered to disrupt their post […] points are available. Even Tiger Woods’ limited-field event, the World Challenge, offers 500 FedEx Cup points. The tour has
20.09.2012 [ESPN Deportes] - ATLANTA -- El inglés Junstin Rose y el estadounidense Tiger Woods lideran The Tour Championship, último torneo de la FedExCup, en el que toman parte los 30 mejores jugadores del circuito estadounidense. Tiger Woods. Getty Images Si el torneo
21.09.2012 [ESPN Deportes] - ... Jim Furyk tomó el relevo al frente del The Tour Championship, último torneo de la FedExCup, en el que toman parte los 30 mejores jugadores del circuito estadounidense, luego de que su compatriota Tiger Woods desapareciera de los primeros puestos.
30.08.2012 [Yahoo! Sports (blog)] - We're used to seeing Tiger Woods' name atop Vegas' golf odds when he's in the field. But for the second straight tournament, he's not the only one listed as the favorite for a FedExCup event. Woods and Rory McIlroy were listed as 7-to-1 favorites last
19.09.2012 [ESPN Deportes] - Rory McIlroy, Tiger Woods, Nick Watney, Phil Mickelson, Brandt Snedeker ganarán la Copa con un triunfo en East Lake. Los jugadores ubicados en el N° 7 o más abajo en el ranking de la FedExCup, deberán ganar sí o sí el Tour Championship, para obtener


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In the age of the "Occupy Wall Street" movement amidst reverberating cries of the "99 percent versus the 1 percent," one has to wonder whether inclusion on the annual Forbes 400 list of the Richest People in America is actually a good thing.
At a time when the superwealthy are under a microscope, the Forbes 400 list, which yearly chronicles the ups and downs of America's billionaires, might bring some unwanted attention.
Two University of Nevada, Las Vegas sociology professors, however, said Americans are enamored with the wealthy, which often outweighs jealousy.
The U.S. is a nation of social voyeurs.
"The Forbes list is our modernday 'Great Gatsby,'" said Bo Bernhard, the executive director of UNLV's International Gaming Institute. "We're fascinated with the wealthy."
Seven Nevada residents - six of whom are associated with the gaming industry - secured spots on the 2011 list, which was released last September.
Las Vegas Sands Corp. Chairman Sheldon Adelson topped Nevada's field in the No. 8 position with a net worth of $21.5 billion. Forbes adjusted Adelson's net worth in March to $24.9 billion and moved up a spot to No. 7.
Adelson rival Steve Wynn, chairman of Wynn Resorts Ltd., was the next wealthiest Nevadan at No. 130 with a net worth of $2.8 billion.
Four others who live outside Nevada, but have significant ties to the Strip, also made the list, topped by New York hedge fund manager John Paulson, whose company owns large chunks of MGM Resorts International, Caesars Entertainment Corp. and Boyd Gaming Corp. Paulson was listed at No. 15 with a net worth of $15.5 billion.
Bernhard and Shannon Monnat, an associate professor in UNLV's sociology department, said the list has experienced some radical industrial shake-ups in the past few decades. Monnat said the Forbes list had once been "composed of people who actually made things. Increasingly, the list is (now) composed of hedge fund managers, investors and real estate moguls."
Bernhard said the gaming industry is no longer just a Nevada business, but a worldwide conglomerate where massive amounts of money are wagered legally. In 2010, commercial casinos nationwide collected $34.6 billion in taxable revenues.
"The modern casino-resort, which was created in Las Vegas, is how people get their entertainment," Bernhard said. "The list is reflective of the products of the day, which is why you see gaming represented. If history is followed, other industries will disappear."
The Forbes 400 list had often been considered something to which Americans could aspire. Through hard work, good decisions and innovative ideas, poor Americans stood a chance at becoming wealthy individuals.
Monnat said the "rags-to-riches" story can still happen, but it's much less likely than it was 30 years ago. She cited Microsoft Corp. founder Bill Gates, who topped the list for the 18th straight year with $59 billion in net worth, and Adelson, as individuals that could be considered "self-made."
However, substantial historical and contemporary structures have been created in the past few decades that favor certain groups in wealth acquisition.
"Since wealth is often accumulated intergenerationally, this means that it is unlikely that a significant proportion of families without substantial wealth now will have wealth in the next generation," Monnat said. "Even within the top 400, a small percentage of that group is self-made. The rest had a huge head start thanks to the wealth their parents and grandparents had previously accumulated."
She noted six members of the Walton family, which founded the Wal-Mart Stores retail chain, were in the Forbes 400, including four members in the top 11. Nancy Walton Laurie, who lives in Henderson, was at No. 139 with a net worth of $2.7 billion and was the only Nevadan on the list without a casino industry tie.
Adelson had reached as high as No. 3 on the Forbes list in 2007 - saying at the time that he aspired to be No. 1.
After growing up poor in Boston, Adelson created several businesses, including a company that produced a big computer industry trade show. He sold the businesses for millions of dollars after he bought the Rat Pack-era Sands Hotel on the Strip in the early 1990s.
That $167 million investment in an aging hotel-casino was the start of Las Vegas Sands, which now has a market capitalization of more than $41 billion and operates The Venetian and Palazzo hotel-casinos on the Strip and properties in Macau, Singapore and Pennsylvania.
Adelson almost lost it all in 2008. Late that year, he invested more than $1 billion as part of a $2.1 billion recapitalization of Las Vegas Sands, which kept the company from falling into bankruptcy. His ownership stake declined from more than 80 percent to 53 percent, but his actions turned around the casino operator and bouyed Adelson's own sinking fortunes.
His position on the Forbes list in 2011 grew five places over 2010, marking a steady comeback. Forbes said Adelson continued "to enjoy a hot hand."
Adelson told Forbes in September that as his wealth increases, he donates additional money to cancer research.
But it's Adelson's political contributions this year that have attracted the most attention.
Adelson and his family donated more than $15 million to the ultraconservative political action committee that supported Newt Gingrich's presidential bid. Earlier in April, he gave $5 million to the PAC supporting Republican congressional candidates.
Political contributions cut both directions on the Forbes list.
Although Adelson has been heavily critical of the administration of President Barack Obama and contributed to conservative causes, now retired New York hedge fund operator George Soros, who was No. 7 on the list in September, has donated to predominantly liberal causes.
Meanwhile, investor Warren Buffett, who is ranked No. 2 on the list, has said the country's wealthiest pay at least 30 percent of their income in taxes.
Monnat said that no matter on which side of the political spectrum the leading billionaires might land, the Forbes 400 could have a large influence on the political process. Combined, the 400 people on the list have more wealth than the bottom 60 percent of U.S. households.
"This means that 400 people control more wealth than nearly 70 million households combined," Monnat said. "This has major implications for economic policies in this country. Through contributions to political campaigns and super-PACs, the richest Americans have tremendous power to influence election outcomes, taxes, subsidies and business regulations."
A TITLE OUT OF CONTEXT
But we're still fascinated by the comings and goings of the wealthy.
The annual list often contains some interesting changes.
In 2010, Elaine Wynn landed a spot on the Forbes 400, due largely to the monetary settlement with her ex-husband Steve Wynn when they divorced earlier that year. Steve and Elaine Wynn split their jointly owned stock in Wynn Resorts and Elaine Wynn received 11 million shares.
She landed on the list at No. 382 with a net worth of $1.05 billion. In 2011, Elaine Wynn jumped to No. 263 with her net worth climbing to $1.7 billion.
"Elaine has been pretty successful in her own right," Bernhard said.
Elaine Wynn laughed off the inclusion in a 2010 interview with the Las Vegas Review-Journal, saying it didn't change the way she lives her life.
"Being recognized as having wealth really doesn't mean anything," she said then. "What is meaningful is that if you are successful, what is it that you intend to do with it. Considered in context, pointing out somebody is rich is just frivolous, unless it is also put it into context with achievement."
Contact reporter Howard Stutz at email@example.com or 702-477-3871. Follow @howardstutz on Twitter.


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Typically, Thursdays are for throwing it back to something that was posted on the blog, I’ve taken us back to some of my very early posts from four years ago, I’ve kept us in the same month a couple of times, but today I was at a loss. Today, a blog post came up in my Timehop, it was three years ago today that I posted 20 Questions: Sisterly Love. I had thought that I would do a series on the blog where I asked the people in my life the same 20 questions, this was the only piece in the series.
When scrolling through my posts to take me back three years to find 20 Questions, I passed My People. I stopped and smiled. Through a rough couple of weeks those same two people have been the individuals I have turned to in an effort to remain grounded in positivity. They continue to be a pillar of support in my daily life.
It occurred to me yesterday that I cannot remember my first interactions with either of “my people”. I don’t remember how they went from people at work to people that I recognized as someone I could talk to and have a relationship with, but I can’t imagine my life without them. Either of them.
To keep my gratitude for them alive, I’m throwing it back to June for Throwback Thursday today with My People. I may even resurrect The Kindness Challenge to keep me rooted in my gratitude and kindness during this time when I seem to be rooted in frustration and exhaustion.
Here’s to my people – they are simply the best!

domain: psychology


NEW YORK (MainStreet)—Senator Elizabeth Warren (D-Mass.) is gathering support for her bill to lower federal student loan interest rates to the level of the fed funds rate, but so far there hasn't been any movement on the one-year time frame.
A House bill that is a companion to The Bank on Students Loan Fairness Act, which drops the rate on federally subsidized Stafford loans from the Department of Education, has been introduced in by Rep. John Tierney (D-Mass). Warren's bill already has a co-sponsor in the Senate by Jeff Merkley (D-OR).
"Right now, a big bank can get a loan through the Federal Reserve discount window at a rate of about 0.75%," she said Thursday in an email blast to supporters. "Those are the same big banks that destroyed millions of jobs and nearly broke our economy. That isn't right. And that's why I introduced legislation to give students the same deal we give to the big banks. This was my very first bill in the U.S. Senate, and I'm going to fight for its passage."
According to Warren's statement, The Bank on Students Loan Fairness Act would allow students who are eligible for federally subsidized Stafford loans to borrow at 0.75%. "For one year, the Federal Reserve would make funds available to the Department of Education to cover the loans and give students relief from high interest rates while giving Congress time to find a long-term solution," she said. That solution may leverage the difficulty Congress would have in replacing what may become a popular piece of legislation—one that involves a reduction in student loan interest rates—with one that may be extremely unpopular 12 months later—a rate hike.
Tierney engaged this issue with a May 14 op-ed in the Lowell Sun. Kevin McDermott, Tierney's Washington, D.C. based legislative assistant could not be reached for comment.
--Written by John Sandman for MainStreet


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WASHINGTON, March 20—Senator Hubert H. Humphrey said today that the success or failure of the civil rights coalition in the Senate “depends in large part on the activity of the churches and large American business corporations in behalf of the bill.”
The Minnesota Democrat, whho is the floor manager for the bill, told reporters, “The most important force at work today on behalf of civil rights is the churches—Catholic, Protestant and Jewish.”
He said that the second most important force was big business. The help that large corporations can give, the assistant Democratic leader said, “should not be underestimated.” He said that the corporations had reasons of economic selfinterest for wanting the measure enacted.
Disorder and strife interrupt business activity, Senator Humphrey said. On the other hand, he said, some provisions of the bill would stimulate business activity by opening up facilities now closed to Negroes and by eventually making better‐paying jobs available to Negroes.
He referred to provisions prohibiting racial discrimination in employment and in places of public accommodation.Continue reading the main story
Comments on Developments
Mr. Humphrey's statements were made in response to reporters' requests for comment on two developments in the last few days.
First, some Northern and Western Senators have reported a steadily increasing flow of mail against the bill. Second, Southern Senators have asserted that Americans outside the South are at last beginning to understand “what this bill would do,” and that the tide is turning against the measure.
MMany Senators who support civil rights believe the Southerners are “whistling up the wind.” They tend to discount the anti‐civil‐rights mail as not reflecting the predominant view of their constituents.
The Senators have said all along that what differentiates this battle from that of 1957 is that the present bill is backed by the churches and their affiliates and not just by “professional” civil rights groups.
Furthermore, they say the churches have not yet begun to fight and will not mount their all‐out offensive until the end of April.
By that time, it is expected that both sides in the Senate debate will have made their full cases and the Southern filibuster against the measure will have begun in earnest.
According to plans now being made, a convocation of national religious leaders of all faiths will be held in Washington. This will set off convocations in other large cities and special church services inn support of the bill across the country north of thee Mason‐Dixon Line.
On Capitol Hill today, leaders of both sides in the struggle said that an understanding had been reached to vote next Wednesday on the motion to make the bill the pending business of the Senate.
Although Southerners have been discussing the substance of the bill since March 9, the measure is not formally before the Senate. The pending business has been a motion by the Democratic leader, Senator Mike Mansfield of Montana, to call the bill up for debate.
Favors Committee Action
If the motion to call up the bill is passed, as is expected, Senator Wayne Morse will immediately move to send the bill to the Judiciary Committee for hearings with instructions to report it back to the Senate in 10 days. The Oregon Democrat supports the bill but also supports the argument of the Southerners that it is violation of Senate procedure to debate the House‐passed bill without referring it to committee.
Mr. Morse has argued that the nine civil rights supporters on the Judiciary Committee can produce a majority report containing interpretations of the bill that will be essential if the courts are later to know the “intent of Congress.”
He said today that he had received assurance from Mr. Mansfield that no motion would be made to table—that is, kill —his motion before he spoke on it at length.
Senator Humpnnrey and Senator Thomas H. Kuchel of Calitornia, the Republican floor manager, were confident today that they had the votes to defeat the Morse motion. They said they believed they had a minimum of 15 Republican and 36 Democratic votes among the 100 Senators.
Senator John Stennis, Democrat of Mississippi, held the floor for 4 hours 20 minutes today In the speech, his second on the bill, he concentrated on the section prohibiting discrimination in employment and union membership.
Mr. Stennis said this section would “constitute a drastic intrusion into private businesses.” He said it would interfere with an employer's judgment of how best “to build and maintain the most competent, efficient and harmonious working force possible.”
It is very difficult, he said, to define precisely what constitutes unlawful discrimination in employment because of race, color, religion, sex or national origin. For that reason, he said he thought the ban was “unenforeable with any degree of intelligence.”Continue reading the main story

domain: law


text:
Pakistan and Bangladeshs economies will suffer most as global warming imperils fisheriesFebruary 7th, 2009 - 3:24 pm ICT by ANI
Washington, Feb 7 (ANI): A new study has identified Pakistan and Bangladesh as some of the countries that are most economically vulnerable to the effects of global warming on fisheries.
The study, by a team of scientists at the WorldFish Center, the University of East Anglia, Simon Fraser University, the Centre for Environment, Fisheries and Aquaculture Science, the University of Bremen, and the Mekong River Commission, is the first to identify individual nations that are highly vulnerable to the impact of climate change on fisheries.
It determined that with climate change threatening to destroy coral reefs, push salt water into freshwater habitats and produce more coastal storms, millions of struggling people in fishery-dependent nations of Africa, Asia and South America could face unprecedented hardship.
The authors of the report examined 132 national economies to determine which are the most vulnerable, based on environmental, fisheries, dietary and economic factors.
Countries that need the most attention, they said, are those where fish play a large role in diet, income and trade, yet there is a lack of capacity to adapt to problems caused by climate change, such as loss of coral reef habitats to the bleaching effects of warmer waters and lakes parched by an increase in heat and a decrease in precipitation.
Both coastal and landlocked countries in Africa, including Malawi, Guinea, Senegal and Uganda, four Asian tropical countriesBangladesh, Cambodia, Pakistan and Yemenand two countries in South America, Peru and Colombia, were identified as the most economically vulnerable to the effects of global warming on fisheries.
Overall, of the 33 countries that were considered highly vulnerable, 19 are already classified by the United Nations as least developed due to their particularly poor socioeconomic conditions.
The worlds fisheries provide more than 2.6 billion people with at least 20 percent of their average annual per capita protein intake, according to the United Nations Food and Agriculture Organization (FAO).
The highly vulnerable countries identified in the WorldFish study, which was funded by the United Kingdoms Department for International Development (DFID), produce 20 percent of the world”’’s fish exports (by value).
The researchers note that these countries should be a priority for adaptation efforts that will allow them to endure the effects of climate change and maintain or enhance the contribution that fisheries can make to poverty reduction.
According to Edward Allison, director of policy, economics and social science at WorldFish and the research papers lead author, economically, people in the tropics and subtropics likely will suffer most, because fish are so important in their diets and because they have limited capacity to develop other sources of income and food. (ANI)
- 75 percent of world's coral reefs under threat: report - Feb 24, 2011
- Warming climate damaging reefs, impacting fish - Jul 11, 2012
- Study finds how sea urchins affect coral reefs' growth - Jan 15, 2011
- 'Stress test' to identify 'reefs of hope' in climate change era - Mar 23, 2011
- Gujarat coral reefs a virtual gold mine - Mar 27, 2011
- Climate change forces mirgration of Australian tropical fish - Aug 17, 2012
- Warming casts shadow over survival of coral reefs - Sep 17, 2012
- Coral reefs will survive ravages of warming: Scientists - Apr 17, 2012
- More warm, acidic oceans will require greater reef care - Feb 15, 2011
- World's reef fish systems threatened by human overpopulation - Apr 06, 2011
- Marine researchers call for international effort to save coral reefs - Oct 08, 2010
- Protect coral reefs, say scientists - Jul 09, 2012
- Humans increasingly poisoned by reef fish - Sep 11, 2012
- World's coral reefs 'at risk due to overfishing, climate change' - Feb 24, 2011
- Sea cucumbers could protect endangered corals - Feb 01, 2012
Tags: climate change, coastal storms, coral reef, coral reefs, countries in south america, dependent nations, east anglia, effects of global warming, freshwater habitats, landlocked countries, mekong river, mekong river commission, poor socioeconomic conditions, reef habitats, simon fraser university, south america peru, university of bremen, university of east anglia, warmer waters, worldfish center


text:
The Girl in the Green Sweater
A Life in Holocaust's Shadow
In 1943, with Lvov's 150,000 Jews having been exiled, killed, or forced into ghettos and facing extermination, a group of Polish Jews daringly sought refuge in the city's sewer system. The last surviving member this group, Krystyna Chiger, shares one of the most intimate, harrowing and ultimately triumphant tales of survival to emerge from the Holocaust. "The Girl in the Green Sweater" is Chiger's harrowing first-person account of the fourteen months she spent with her family in the fetid, underground sewers of Lvov.
"The Girl in the Green Sweater" is also the story of Leopold Socha, the group's unlikely savior. A Polish Catholic and former thief, Socha risked his life to help Chiger's underground family survive, bringing them food, medicine, and supplies. A moving memoir of a desperate escape and life under unimaginable circumstances, "The Girl in the Green Sweater" is ultimately a tale of intimate survival, friendship, and redemption.
Praise For The Girl in the Green Sweater: A Life in Holocaust's Shadow…
"The Girl in the Green Sweater manages to touch us in an unexpected way, revealing highs and lows in man's capacity for evil, as well his capacity to love life and other human beings." -- Naomi Ragen, author of The Saturday Wife and The Covenant
“With a powerful story and a keen voice, Chiger's Holocaust survivor's tale is a worthy and memorable addition to the canon.”--Publishers Weekly
"An important addition to Holocaust literature that vividly describes a harrowing childhood faced with enormous strength and courage."--Michael Bart, author of Until Our Last Breath: A Holocaust Story of Love and Partisan Resistance
St. Martin's Press, 9780312376567, 288pp.
Publication Date: September 30, 2008

domain: library


Christmas is over you say? Not for college football fans as Wednesday kicks off four straight days chock-full of bowl games with more to follow. Wednesday's slate has a little something for everyone – two of college football's top running backs will share the stage in Dallas; a longtime, successful head coach is set to say farewell in Detroit; and two of the nation's stingiest defenses faceoff in Phoenix.
So if you're wondering, "What college football bowl games are on today?" know this: There are three bowl games scheduled for today, Wednesday, Dec. 26.
1:30 p.m. ET, ESPN — Cotton Bowl in Dallas, Texas
Why You Should Watch: This matchup features two of college football’s top running backs, and both teams are strong on defense. Boston College’s AJ Dillon battled an ankle injury for a chunk of the 2018 season, yet finished with 1,108 yards and 10 scores. Boise State’s Alexander Mattison posted 200 yards in the Mountain West title game and finished the year with 1,415 yards and 17 touchdowns.
Spread: Boise State -2
5:15 p.m. ET on ESPN — Ford Field in Detroit
Why You Should Watch: This will be the final game for Georgia Tech head coach Paul Johnson, who is retiring. has decided to retire after the end of this season. Minnesota upset Big Ten West rival Wisconsin in the regular-season finale to get the Gophers to a bowl game in head coach P.J. Fleck's second season. The Yellow Jackets lead the nation in rushing offense (334.9 ypg) and how well the Gophers (170.7 rushing ypg allowed) hold up against Johnson's flexbone option attack will determine the outcome.
Spread: Georgia Tech -5.5
9 p.m. ET, ESPN — Chase Field in Phoenix, Ariz.
Why You Should Watch: A defensive slugfest is on tap for this matchup in Phoenix. California is only allowing 21.3 points a contest, while TCU isn’t far behind at 24.4. Turnovers will be crucial in a tight game and have been an issue for both teams. TCU is minus-six, and California is minus-two this season.
Spread: Cal -1


text:
Discovering Bali’s Tropical Charms
Bali, renowned for its tropical allure, beckons travelers seeking a paradisiacal getaway. The island’s blend of vibrant culture, breathtaking landscapes, and serene retreats creates an enchanting tapestry that captivates all who visit.
Enveloped in Natural Beauty
Embrace Bali’s natural splendor with its verdant rice terraces, pristine
Exploring Balinese Culture: A Rich Cultural Journey
Understanding Balinese Traditions
Balinese culture is a vibrant tapestry woven from ancient traditions and modern influences. Rooted in Hinduism, it encompasses a myriad of customs, ceremonies, and artistic expressions. From the intricate dance forms like the Legong and Barong to the mesmerizing Gamelan


text:
The director of President Donald Trump’s National Economic Council told a room full of chief executives on Tuesday that they likely don’t need to worry about their private jets being taxed.
Speaking at a White House “town hall” with executives about infrastructure, NEC Director Gary Cohn said the Trump administration wants to upgrade air-traffic control as part of an infrastructure plan.
He said the CEOs may be against a forthcoming plan if there’s a tax on general aviation — which would include their private jets.
But he added: “We’re probably not even going to tax general aviation.”
President Barack Obama was a proponent of taxing corporate jets.
At the same event, Transportation Secretary Elaine Chao told CEOs the administration is eyeing a legislative proposal in late May.


text:
"Early nineteenth-century France had Balzac, we have Tim Pears" - "The Times". "Tim Pears specialises in grand panoramas of our national life: teeming casts and multi-tracked plotting heavy with the scent of zeitgeist" - "Guardian". "His genius lies in telling a story"- "Daily Telegraph". In this, his fourth novel, the highly acclaimed novelist Tim Pears again creates a unique portrait of the world in which we live. John is a successful businessman, happily married with a wife and baby. Why is he circling the ring road of his city, unable to face his family, his work, his brother? As he passes the same exit again and again, his life unfolds in front of the reader. And as the story progress, it becomes steadily more sinister as we are forced to see the dilemma at the heart of this novel - how well do we ever know those we work with, live with, place our trust in? This gripping novel is a stunning exploration into what it means to live in these times and who exactly is the enemy.
Tim Pears was born in 1956. He is the author of three novels: IN THE PLACE OF FALLEN LEAVES (winner of the Hawthornden Prize for Literature and the Ruth Hadden Award), IN A LAND OF PLENTY and A REVOLUTION OF THE SUN. Tim Pears lives in Wales and Oxford.


text:
Rags to Riches: The Quilt as Art - Hardcover
Works and Words by Laurie Swim, Introduction by Mary Pratt
In Rags to Riches: the Quilt as Art, Laurie Swim tells her story in pictorial appliqué. Laurie's charming account of the conception and creation of her art is detailed in this 96-page book. Available in soft or hardcover, each book comes personally signed by Laurie.
Share the details of your shipping policy.
Share the details of your return policy.

domain: hobby


Launceston’s trusted auto instrument service
Get in touch with Launceston’s experienced auto electrical team at JLH Auto Electrical. We provide an expert auto instrument service to ensure your car is well maintained at running at its best. Our emphasis is on efficiency, effectiveness and electrical excellence. Get in touch with our team for any of your auto electrical needs.


text:
Professor Ray Roennfeldt has closed a conference in London exploring unity in diversity within the Seventh-day Adventist Church. His message: treating each other justly and equitably is as important as correctly interpreting Scripture. Public Relations Officer Brenton Stacey asked Roennfeldt about Scripture and the church and how he reconciles his reading of one with the practice of the other.
Read more at the source: Justice, equality in my own words
Article excerpt posted on en.intercer.net from News.


text:
How It Became So Easy to Ignore the Poor
In college, I volunteered with a homeless outreach program. “Just talk to the people on the streets,” the campus minister told us. “Have a conversation with them. Treat them like regular human beings.” In other words, be like the Good Samaritan whose first act was to come near and see. Social service organizations could meet the physical needs of the homeless, but it was our task to provide them with dignifying, caring, and sincere human interaction.
For two years, I built relationships with the regulars that hung out near campus, learning about their families, their Vietnam War service, their professions and hobbies. Most importantly, I learned that I, a young adult at a private university, was not so different from them. Some had once lived lives similar to mine before facing difficult and unexpected turns.
Truth be told, I’ve had trouble holding on to that lesson. As I’ve gotten older and more preoccupied with work and family, I tell myself ...1

domain: sociology


text:
in this issue
Markets :: Fine Chemicals/Biotech :: Pharmaceutical ingredients
Pharma/fine chemicals roundup—23 July 2013
9:16 AM MDT | July 23, 2013 | Deepti Ramesh
Albemarle’s fine chemistry business reports lower sales, profits Albemarle says that sales from the company's fine chemistry segment decreased by 15.6% in the second quarter compared with the year-ago period, to $176.1 million, mainly because of lower sales volumes and unfavorable pricing. Profits in the fine chemistry segment decreased 25% in the second quarter, to $34.4 million, because of unfavorable pricing, lower factory operating rates, and the timing of custom services projects, Albemarle says. Pharmaceutical exports rise in...
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domain: economics


Keeping your home neat and tidy is no easy task. From wine and food spills, muddy footprints, dust and pet stains can make the whole affair very tedious. It becomes difficult to keep the carpet clean and without stains.
With many products, solutions, tips and formulas, it might get a little overwhelming to find the right product that can actually help you removing stains and spills. To keep you from giving embarrassing explanations to your house guests, here are some of the best carpet stain removers that bring just the relief you were looking for.
Resolve Carpet Triple Oxi Advanced Carpet Stain Remover
Resolve Carpet Triple Oxi Advanced Carpet Stain Remover has been given a place among the best carpet stain removers because it removes stains, gets rid of odor and refreshes everything in just one spray. Tough, stubborn wine, ink, mud, oil, dirt, grease and polish stains can also be easily lifted with this product. It contains special ingredients and a three-step stain removal system. The product is easy to use, safe and does not contain any irritants.
Sunny and Honey Enzyme Cleaner, Pet Stain Remover and Odor Eliminator
This product works on almost all surfaces and also eliminates odor along with stains. The fragrance of this remover leaves the entire atmosphere clean and fresh. It works wonders on carpets, rugs, leather, metals, floor, bedding, upholstery, cardboard and other such tough surfaces. One of the best carpet stain removers, this product is mild and gentle and does not cause any kind of discomfort to the surrounding. It is safe to be used around kids and pets.
Woolite Advanced Pet Stain And Odor Remover
Woolite Advanced Pet Stain And Odor Remover is perhaps one of the best carpet stain removers. It is the best product to deal with the stains caused by pets. It clears off any foul odor from the air right from its root. It also sanitizes the spot in which it is used and makes it almost germ-free.
Dyson Dyzolv Spot Cleaner
Dyson Dyzolv Spot Cleaner works with four active agents in removing stains. It mobilizes and clears the stain with speed drying. It does its wonders on tough spills such as wine, food, and ink and works well on surfaces like carpets, rugs and wool. Dyson Dyzolv Spot Cleaner removes stains instantly and prompts us to include it on our list of best carpet stain removers.
Biokleen Bac-Out Stain And Odor Remover
Biokleen Bac-Out Stain And Odor Remover is eco-friendly and chemical free, making it the best carpet stain remover to use around kids and pets. Its live enzyme-producing cultures attack the toughest of tough stains from deep within. It is free from harmful chemicals like ammonia, chlorine and other such pollutants.
Hoover Platinum Collection Professional Strength Instant Stain Remover
With just one application, Hoover Platinum Collection Professional Strength Instant Stain Remover is found to remove stains and odor. It is easy to use and works rapidly. It does not do any damage to the surface it has been used on. It is set to remove difficult stains in no time, making it one of the best carpet stain removers.
BISSELL Professional Power Shot Oxy Carpet Spot and Stain Remover
BISSELL Professional Power Shot Oxy Carpet Spot and Stain Remover is among the best carpet stain removers because it is equipped with an oxygen component that lightens the stain before it completely removes it. It can also remove old, set-in stains effortlessly. The oxygen technology in this product, not only clears stains but also protects the carpets from future spills and stains.
Capture Carpet Dry Cleaner
Capture Carpet Dry Cleaner in a dry carpet cleaner and it is usually used to remove stains from liquids. To be called one of the best carpet stain removers, it absorbs moisture and prevents from the further spreading of stains.


text:
First time at this restaurant - food was ready and really good. I plan on going back.
Good food at a decent price.
The food was good, but the entree was too soupy so it made a mess all over the bag and the crab Rangoon was too greasy.
It was delicious!
very quick. order was already made by the time i go there and everything was correct. will definitely try again.
Always enjoy your food!
Great portion size, amazing flavor, very fresh.
Food was ready & hot when I picked it up. Staff was courteous & friendly. Picked up order thru the drive thru. Easy. Food was delicious as always
As usual, everything was delicious. Food was ready when I got there and still hot when I got home. They always remember to put everything you need in the bag, ie; forks, spoons, napkins, sauces, ketchup, etc. Served with a smile and budget friendly.
Everything at this place is good.This was an add on to a previously placed order. Try the sesame chicken. It is the best. House fried rice or plain fried rice is my favs. Wonton soup also one of the best.
They do really good, taste fresh. I like that you can "pick" your spicy level. Everything was ready to go at the right time. Love their egg rolls.
Any questions please call us.
New Wok Chinese Cafe
2330 Gessner Dr, Houston, TX 77080
All Rights Reserved

domain: food


text:
How COVID-19 May Make Mental Health Problems Worse This Winter
Dani Hoover is a 26-year-old social worker in Indianapolis. She has battled depression and anxiety since high school, and the pandemic hasn’t made it any easier.
“I think during this pandemic, I've gone through what I would consider my worst, lowest point with my mental health,” Hoover says.
Now Hoover is worried about the winter, when depression usually hits the hardest. She may not be able to do things that help her cope.
“So whether that means like going for a walk or driving somewhere or going to a park, like being able to access a different place that isn't where all those negative emotions started, is really big for me,” she says. “So, knowing that in the winter my options for that are going to be extremely limited, is scary.”
Hoover’s fear is justified, according to mental health experts.
Kevin Rand, a psychology professor at Indiana University-Purdue University Indianapolis, says COVID-19 has had a huge impact around the world.
“I think this is a major global stressor,” he says. “And even if you have not had prior issues with mental health, or psychopathology, that this would be sort of a perfect storm that would give rise to clinical levels of depression and anxiety.”
Rand says a big concern this year is seasonal affective disorder, which he describes as a type of depression. “When people start to experience negative mood, usually beginning in the fall around this time of year, and they notice a consistent drop in their mood that usually lasts until the spring.”
He says experts theorize this is due to significant drops in sunlight. “And so as daylight becomes less and less available as the winter sets, some of us can experience what's known as the phase shift where our natural sleep wake cycle gets out of whack with the 24 hour clock of the day."
That can lead to mood changes and depressive symptoms — like a lack of energy.
“So, I think anybody who experiences depressive symptoms is going to feel it stronger this year,” Rand says.
Research bears that up. The U.S. Centers for Disease Control and Prevention says symptoms of anxiety and depression increased between April and June. One study showsmore than 40 percent of adults reported adverse effects of mental health or substance abuse because of the pandemic.
Shelley Johns, a researcher at the Regenstrief Institute in Indianapolis and a clinical psychologist, has seen an
increase in depression and anxiety in her patients since the pandemic began.
“You know, we've been into this for more than six solid months, in the U.S.,” she says. “And just the stress has become chronic, and there really is still no, big end in sight.”
Johns says it is important for people to be proactive with their mental health and find coping mechanisms that work for them.
“Making sure that you're getting the appropriate amount of sleep that your body typically needs this time of year,” Johns says. “Making sure that you're staying involved in social activities, even if it has to be socially distanced, or it has to be all via phone or the web, making sure that you're moving your body and getting out in the sunlight as much as you can, as safely as you can.”
Hoover has created a calming corner in their home to help get through the next few months.
“There's comfy pillows and blankets, and books and materials and just anything like that, that I can use,” she says. “I'm struggling with what I'm going to do about the physical space. But I know for me, it's like the coping mechanisms I like to use are the material, artsy things.”
Rand also recommends special light boxes to help people get through seasonal depression. He says they’re available at places like Amazon.
“What you need is a light box that gives you about 10,000 lux of light,” he says. “And just kind of expose yourself to that for about 30 minutes in the morning, that has been shown to have a pretty good effect on depressive symptoms.”
Rand says if someone’s depression or anxiety is severe, they should contact a health professional. But the most important thing for people who struggle with mental health during the colder months is to remember spring will eventually come.
“Accepting that you're going to probably feel worse this winter than in previous winters,” Rand says. “And that it's hard. But it will be temporary, and it will get better.”
This story was produced bySide Effects Public Media, a news collaborative covering public health.
Copyright 2021 Side Effects Public Media. To see more, visit Side Effects Public Media.


If you wear the right gear for your night sessions, you won’t have to worry about your safety. Choose a quality glow-in-the-dark jacket that keeps you visible and dry while you’re focussing on training. Combining safety and performance has always been our speciality. Make the most of our unique ZAP technology and enjoy your rides no matter the conditions.
- Reflective ZAP technology providing night illumination through tiny micro-glass lenses
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Fabric: Zap LT Woven, 100% Micro-Glass Bead Polyester, 100% Polyurethane coating on the back
|BUST (cm)||80 - 84||84 - 89||89 - 95||95 - 103||103 - 109||109 - 114|
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Never use detergents or stain removers containing bleaching agents or additives. Even a minute quantity can damage the fabric. The use of additives can leave traces on a fabric’s fibers that can hamper certain technical performances. The best rule to follow when choosing is detergent is going for the simplest. We suggest choosing a detergent that contains the words "transparent" or "nature" in its name. Do not pour the detergent directly onto the fabric, but rather pour it into the washing machine when turning the water.


text:
Sökning: "Catalyst immobilization"
Visar resultat 1 - 5 av 13 avhandlingar innehållade orden Catalyst immobilization.
Sammanfattning : The topic of this doctoral thesis is the potential near field immobilization of the radionuclide 79Se after intrusion of groundwater into a spent nuclear fuel canister in a repository. 79Se is a non naturally occurring long lived selenium isotope formed as a result of fission in nuclear fuel. LÄS MER
Sammanfattning : Catalytic systems are one of the most effective technologies of modern chemical processes. The system uses a molecule called ‘catalyst’ that is capable of catalyzing a reaction without being produced or consumed during the process. LÄS MER
3. Flavins as Biomimetic Catalysts for Sulfoxidation by H2O2 : Catalyst Immobilization in Ionic Liquid for H2O2 Oxidations
Sammanfattning : This thesis deals with the development of catalytic oxidation reactions utilizing hydrogen peroxide as terminal oxidant. The main focus has been to find flavin catalysts that are easy to handle and stable to store but still able to perform the desired reaction. LÄS MER
Sammanfattning : The theme of this thesis is the development of mononuclear Ru-based complexes that are capable of catalyzing the water oxidation (or O2-evolving) reaction, e.g. 2 H2O → O2 + 4 H+ + 4 e−. Several families of mononuclear Ru water oxidation catalysts were designed and prepared. LÄS MER
Sammanfattning : Four different catalytic systems were studied for biomimetic coupled oxidations using H2O2 or O2. In the first example, osmium tetroxide works as a substrate-selective catalyst for dihydroxylation of olefins. Electron transfer to H2O2 is facilitated by electron transfer mediators (ETMs). LÄS MER

domain: chemistry


text:
Anyone can find the time to make a difference. Need proof?
Sally Kidd is the senior correspondent for Hearst Television, covering the White House, Congress and federal agencies for the Hearst network of 26 stations.
She’s also a triathlete who is about to combine her passions for fitness, travel and adventure into a trek to Africa to climb Mount Kilimanjaro for a great cause.
She says climbing Mount Kilimanjaro just seems like the ultimate challenge.
Sally says her interest in climbing one of the world’s tallest mountains was sparked 10 years ago when she interviewed a judge how had just returned. He told her that it didn’t require a lot of technical skill, and he had climbed it to celebrate his 50th birthday.
The idea stuck with her.
So this August, just four months before her own 50th birthday, Sally and her friend and fellow triathlete, Tracey Ford, will head to Africa to conquer Mount Kili.
In the meantime, they’re training with hikes and camping trips, and keeping up their fitness regimes — just two months after the climb, they’ll both compete in an Ironman triathlon.
Sally says it’s important for people to know that she’s a “back of the pack” triathlete — she’s usually one of the last to finish a race. But she says that’s just proof that anyone can get out there and do what they want to do, including climbing toward the top of the world.
She explains why they’ve chosen to raise $19,340 for the Global Alliance for Africa and explains how simple it is for you to help them reach their goal.
You can follow their adventures by visiting their website www.triathleteshikingkili.com

domain: geography