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ZEIGLER — It’s three goals down and one to go for Zeigler-Royalton after defeating Waltonville 5-3 in Monday’s Class 2A Regional championship showdown.
“We had four goals coming into the year,” said Zeigler-Royalton coach Page Kirkpatrick. “That was to break the school record for wins, win the conference and win a regional.”
Now that 1-3 are checked off, Kirkpatrick said there’s one goal that remains.
“We are trying to get to the Sweet 16, which you’ve got to win another game to do that,” he said. “We’re trying to get to places that we haven’t been before. Obviously, we’re just tickled to be playing and to be successful is the cherry on top.”
The Tornadoes now own a 24-5 record and are set to face Harrisburg in Wednesday’s sectional semifinal. The Bulldogs also crowned themselves regional champions on Monday with a 15-0 win over Vienna in four innings.
Ziegler Royalton’s Trey Cole finished 2-for-3 with a home run, double and three RBI’s in Monday’s win over Waltonville. The sophomore spoke about facing the Bulldogs, who rank fifth in the state according to the MaxPreps Class 2A High School Baseball Rankings.
“We haven’t seen them yet this year,” Cole said of Harrisburg, “We’ve just got to play great defense, hit the ball and keep up with what we’ve been doing all year.”
That motto stuck true for Cole when he launched a two-run home run in the third inning that gave Zeigler-Royalton a 5-2 lead over Waltonville. Hitting out of the No. 4 spot, Cole scored Cole Freeman on an RBI double in the first inning to put the Tornadoes ahead of the Spartans 1-0.
Cole would end up coming around to score in the first after Mason Goins struck an RBI single to put the Zeigler-Royalton lead at 2-0. Waltonville starter Mike Emery took the loss after allowing two earned runs on three hits through three innings.
“We played them early on in the year,” Cole said of Zeigler-Royalton's 11-1 victory over Waltonville on May 13, “so we knew (Emery) was mainly a fastball pitcher and could spin it a little bit. I just sat back on a fastball.”
Freshman Scout Hudgens earned the victory for Zeigler-Royalton in a complete game effort. Hudgens allowed two runs in the third inning that tied the game at 2-2, but his offense answered in the bottom half after Cole homered and Freeman hit a sacrifice fly that scored Anthony Rolla for the three-run cushion.
Hudgens now owns a 6-1 record this season. His 108 pitches on Monday only struck out two Spartans, but he had the defense behind him to make plays when it counted.
“I felt really good,” said Hudgens. “Coming through the third inning, I really picked up on everything and my defense was there to pick me up every time.”
Zeigler-Royalton’s defense had a game. When it was Hudgens, he worked his way out of a bases loaded situation in the first inning by getting Quinn Gajewski to ground into a 6-3 fielder's choice. He also managed 1-2-3 innings in the second and fifth frames on 19 pitches.
But when Waltonville scored twice in the third after Gavin Woodland crossed home on a wild pitch and Blake Menser scored Nate Ragland on an RBI double, the Tornadoes’ defense stood up. This came after Gajewski drove a two out double for Menser to round third, but a perfectly executed cut-off throw from center-fielder Colin Sveda to Cole at second caught Menser at the plate on a Nick McKinney tag.
That play kept the score at 2-2 and Zeigler-Royalton took the lead in the third to give Hudgens momentum on the mound.
Waltonville tacked on a run in the seventh when Gajewski struck a solo home run off Hudgens with two outs, but the pitcher closed the game by getting Woodland to strikeout looking on a full-count fastball.
“It kind of brought me down a bit but I stayed high and trusted my team,” Hudgens said of the Gajewski homer.
Waltonville coach Joe Emery and his team expected to face good pitching and hitting.
“The first time we played them they short-gamed us, so this game we came in with the attitude that we didn’t have anything to lose,” he said. “Just like the first game against Trico, we just wanted to come in here and compete, but that home run they hit was big for them to go up.”

domain: game


Musicians come to Israel despite bullying of BDS
Jul 12, 2013 | Sharyn Mittelman
Fourteen-time Grammy winner Alicia Keys is the latest musician to defy the ugly bullying and harassment from Boycott, Divestment and Sanctions (BDS) activists and perform in Israel.
On July 4, Keys sang to a sold-out crowd in Tel Aviv, to promote peace through music. For one song, she was joined by popular Israeli musician Idan Raichel. Before performing her song “Listen to Your Heart,” Keys reportedly told the audience: “People are always trying to tell us what’s right for us and what isn’t. Instead of listening to them, you should listen to your heart.” This appears to be a reference to the hateful bullying she received following news that she would be performing in Israel. Keys’ Facebook page was targeted with abusive comments regarding her decision to perform in Israel.
Despite such tactics, Keys decided to perform in Israel, telling the New York Times over a month ago: “I look forward to my first visit to Israel,” adding, “Music is a universal language that is meant to unify audiences in peace and love, and that is the spirit of our show.”
Keys received support from several individuals and organisations including Creative Community For Peace (“CCFP”), which on its website notes that it represents “a cross section of the creative world–those who create and help create music, films, and television programs–and their fans.” CCFP’s members from the music industry include Jody Gerson, co-president of Sony/ATV Music Publishing; Ron Fair, former chair of Geffen Records; and Rob Prinz, head of music at United Talent Agency. Together the group represents the likes of Celine Dion, Aerosmith, Jennifer Lopez and Justin Timberlake and many others. CCFP wrote an open letter criticising Alice Walker’s letter to Keys as “misleading” and organised a petition with over 18,000 signatures supporting artists to play in Israel.
The letter stated:
“Israel is a democratic country with a diverse population, where women, Arabs, Muslims, Christians and all minorities have equal rights; a nation where art and freedom of expression flourish. Citizens of all ethnicities mingle openly in public arenas, sit side-by-side in restaurants and are free to speak their minds and vote their consciences. The recently crowned Miss Israel is from Ethiopia. In apartheid South Africa or the pre-civil rights American South, that would have been unheard of.
The great Martin Luther King Jr. had this to say this about Israel: ‘Israel is one of the great outposts of democracy in the world, and a marvelous example of what can be done, how desert land can be transformed into an oasis of brotherhood and democracy.’
False comparisons of Israel to apartheid South Africa and the pre-civil rights American South diminish the real human suffering of those times. South African Member of Parliament Dr. Kenneth Meshoe, who grew up in apartheid South Africa [and] knows the tyranny of oppression, wrote the following in his May 15 op-ed in the San Francisco Examiner.
‘As a black South African who lived under apartheid, this system was implemented in South Africa to subjugate people of color and deny them a variety of their rights. In my view, Israel cannot be compared to apartheid in South Africa. Those who make the accusation expose their ignorance of what apartheid really is… Israel is a model of democracy, inclusion and pluralism that can be emulated by many nations, particularly in the Middle East.'”
CCFP outlines why it is against BDS on its website:
“We may not all share the same politics or the same opinion on the best path to peace in the Middle East. But we do agree that singling out Israel, the only democracy in the region, as a target of cultural boycotts while ignoring the now-recognized human rights issues of her neighbors will not further peace. We understand the power that our music, our films, our television shows, and all arts have. They have the power to build bridges. Foster better understanding. Encourage dialogue. And hopefully lead toward greater mutual acceptance. If anything, turn up the music, expose more of our films and television shows to wider audiences, and encourage people from all cultures to interact and build greater dialogue and understanding. If you support the message that the arts can build bridges-please join us in this important mission.”
Other artists who have also recently defied BDS harassment and performed in Israel include Paul McCartney, Lady Gaga, the Red Hot Chilli Peppers, Black Eyed Peas, Missy Elliott, Alanis Morisette, Elton John, Leonard Cohen, Rhianna and Shakira. Shakira commented:
“I’m very proud of my Lebanese heritage… but it has nothing to do with the fact that I respect and have great affection for this country and the people of this country, both Israelis and Palestinians, and that’s why I’m here, because I think that kids need us – kids don’t understand about conflicts” and added “We are all Israel.”
Madonna performed in Israel in May 2012 despite strong opposition by BDS activists, and called her concert a “peace concert”, offering 600 free tickets to the show to various Israeli and Palestinian peace activists. Madonna said of starting her tour in Israel:
“I chose to start my world tour in Israel for a very specific and important reason. As you know, the Middle East and all the conflicts that occur here and that have been occurring for thousands of years, they have to stop. You can’t be a fan of mine and not want peace in the world.”
Last month Barbara Streisand performed at Shimon Peres’ birthday concert in Israel, and she was joined by other A-list celebrity guests that included Sharon Stone and Robert De Niro.
Meanwhile, British pop duo, the Pet Shop Boys, comprised of Neil Tennant and Chris Lowe, were also targeted by anti-Israel activists and bullied not to perform in Israel in June. One pro-BDS poster showed Tennant and Lowe wearing glasses with the captions “1 child killed every three days” and “2 kids caged every day.” Tennant responded on the Pet Shop Boys official website, refuting the often-made claim by BDS activists that Israel is an apartheid:
“I don’t agree with this comparison of Israel to apartheid-era South Africa,” noting that “It’s a caricature. Israel has (in my opinion) some crude and cruel policies based on defense; it also has universal suffrage and equality of rights for all its citizens, both Jewish and Arab… In apartheid-era South Africa, artists could only play to segregated audiences; in Israel anyone who buys a ticket can attend a concert.”
The arts – especially music – is uniquely capable of bringing people together and promoting a universal message of peace, in contrast to BDS which seeks to entrench division. When artists, especially socially conscious artists like Keys, stand up to the BDS movement, it is a win against a campaign that hurts Israelis, Palestinians and the prospects for peace.


Belgian guitarist Philip Catherine has performed with the creme de la creme of modern jazz and fusion. Noticeably inspired by the late great Django Rheinhardt, Catherine has emerged as a true stylist who melds lush romanticism with bold, simmering lines, witnessed here on Blue Prince.
The guitarist utilizes his warm-toned hollow bodied electric guitar to great effect via shrewd employment of volume control techniques, jazzy chord progressions and scathing leads, evidenced on the often blistering yet predominately cool and sleek Bop-ish burner, “Coffee Groove”. Trumpeter Bert Joris proves to be a near perfect foil for Catherine, as the twosome frequently engage in brisk unison choruses, while also trading sprightly fours during this groove-laden set primarily consisting of medium tempo swing motifs.
The band turns in a peppery walking blues, titled “The Creeper” and continues along with a series of pieces featuring amicable melodies and sonorous themes amid sympathetic accompaniment by the rhythm section. On, “Blue Prince” Joris articulates Chet Baker-style, understated lyricism as everyone gets a spot to exhibit their wares, yet a few more accelerated or rapidly paced pieces tossed into the mix might have elevated the excitement factor a few notches. Otherwise, Blue Prince is a solid and expertly executed effort, as Catherine implicitly illustrates why he is one of the finest guitarists on the globe.
Coffee Groove, Global Warming, With A Song In My Heart, The Creeper, The Postman, More Bells, Memories Of You, Kwa Heri, Blue Prince, Arthur Rainbow, Magic Box, Sweet Lorraine
Philip Catherine; guitars: Bert Joris; trumpet, bugle: Hein Van de Geyn; double bass: Hans Van Oosterhout; drums
Title: Blue Prince
| Year Released: 2000
| Record Label: Dreyfus Jazz
All About Jazz & Jazz Near You were built to promote jazz music: both recorded and live events. We rely primarily on venues, festivals and musicians to promote their events through our platform. With club closures, shelter in place and an uncertain future, we've pivoted our platform to collect, promote and broadcast livestream concerts to support our jazz musician friends. This is a significant but neccesary effort that will help musicians now, and in the future. You can help offset the cost of this essential undertaking by making a donation today. In return, we'll deliver an ad-free experience (which includes hiding the bottom right video ad). Thank you.
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- Sep 3, 2013
Hello everyone! I am from a little town northwest of Cincinnati and I recently started raising a small flock of 30 chickens. This summer I built the chicken coop and the feeder and waterer for the chickens thanks to some of the pictures on the site and a little ingenuity. I will soon post my results and look forward to getting very useful advise on raising my chickens. Anyone else on this site from the Cincinnati area???

domain: agronomy


Many misconceptions exist around sun exposure and the negative effects of UV rays on your health. We want to empower you to practice sun safety habits for better long-term health by up-leveling your sun IQ.
ABOUT ULTRAVIOLET (UV) RADIATION
The sun sends energy to our planet in a few ways:
- light that you can see,
- infrared radiation that you can feel as heat, and
- rays of Ultraviolet radiation that you can neither see nor feel.
We need exposure to the sun to create Vitamin D, but too much of any of the above energies can cause bodily damage; and UV radiation is the cause for the most common form of cancer in the United States, skin cancer.
There are three types of Ultreviolet rays:
Ultraviolet A rays (UVA)
- UVA rays = skin aging and eye damage.
- They can lower your body’s ability to fight off illness, and contribute to the risk of skin cancer
- Almost all UVA rays reach pass through the earth’s atmosphere
Ultraviolet B rays (UVB)
- UVB rays = sunburns, skin cancer, skin aging, and snow blindness (a sunburn to your cornea that causes a temporary loss of vision).
- They can also lower your body’s ability to fight illness.
- The Earth’s atmosphere shields us from most UVB rays.
Ultraviolet C rays (UVC)
- UVC rays do not reach the Earth’s surface
THE LASTING EFFECTS OF THE SUN’S ULTRAVIOLET RAYS
You might have heard the phrase, ‘a healthy tan,’ but there is no such thing.
DID YOU KNOW: Tanning is your body’s attempt to protect itself from being damaged by ultraviolet (UV) radiation.
UV radiation damages your DNA and is the leading cause of visible signs of aging as well as skin cancer.
QUICK FACTS TO KNOW
- 90% of visible signs of aging are due to sun exposure
- UV rays can damage your skin in as little as 15 minutes
- Even on a cloudy day, you can be sunburned by UV radiation
- 80% of UV rays pass through clouds on an overcast day
- Nearly half of UV radiation is received between the hours of 10am and 4pm, when the sun’s rays are the strongest
TAKE THE SUN SAFETY QUIZ
Take the American Cancer Society’s sun saftey quiz and make sure you are sun-safe everyday.
THINGS YOU CAN DO TO LOWER YOUR UV EXPOSURE
We have listed the best ways to limit your UV exposure and risk of skin cancer on our blog. Read it here.
- Limit time in the midday sun.
- Do everything you can to not burn. Sunburns significantly increase the lifetime risk of developing skin cancer, especially for children.
- Use extra caution near water, snow and sand. These three materials reflect the damaging rays of the sun, which can increase your chance of sunburn.
- Watch the UV Index. The UV Index provides important sun safety information to help people plan outdoor activities.
SELF-CHECK FOR SKIN CANCER
Most skin cancer can be cured when caught early, so regardless of your UV ray exposure, it’s important to do a monthly self-check.
Things to look for:
- Any skin abnormalities
- Bumps or sores that don’t heal
- Moles that have changed size, color or shape
It’s important to visit your physician or a dermatologist for regular skin checks and to have any of the signs listed aboved checked out.
Request an appointment today to visit our clinic and message us with any questions you may have. We’re here to help you enjoy the sun without risk.


NEWNow you can take heed to Fox Information articles!
Laura Ingraham illuminated the “eroding” of America’s financial place with China and the Biden administration’s impression Wednesday on “The Ingraham Angle.”
LAURA INGRAHAM: What’s desperately wanted… is a president who does not provide faux empathy when what we want are actual options. However faux empathy is all he can provide, and it is precisely what we obtained when he went on to Chicago.
Biden tried to make you are feeling higher concerning the disastrous state of our economic system and our decrease way of life by evaluating life on the peak of the pandemic to the times of Biden infrastructure bucks.
INGRAHAM: I BELIEVE THE GOAL OF THIS LEAK WAS TO ‘TERRORIZE’
Do his speechwriters not see the irony right here? Just a few hours earlier, he gave a speech about inflation and rising costs of meals and fuel. And, after all, greater than 43% up now. Prices which are resulting from his insurance policies. However maybe the White Home missed this headline about how inflation is so dangerous that some girls say they’re skipping meals now with a view to meet their household’s meals price range. However none of what Biden is doing goes to make any distinction. His transfer to launch the 30 million barrels from our Strategic Petroleum Reserve was worse than a flop. It is now compromising our nationwide safety by depleting our power supply that was being saved for emergencies.
In the meantime, if that is not sufficient, the White Home is planning to additional erode our financial place vis-a-vis China. The globalists contained in the Biden administration are on the verge of convincing Scranton Joe to assist the CCP by dropping Trump’s tariffs. And apparently, for that nice deal, America will get nothing. Now, bear in mind, China is so sleazy, so dishonest, it hasn’t even lived as much as its Part One settlement to purchase $200 billion value of agricultural merchandise from us. It clearly knew that with Trump out once they agreed to it, they might welch on the discount and there’d be no penalties underneath Biden.
So how dangerous will this be? Already, with Trump’s tariffs in place, China is on tempo to take pleasure in a commerce surplus of over $400 billion with the US this 12 months alone. So the best way issues look, Biden is just going to declare that that entire tariff factor was a mistake that simply contributed to greater costs for all customers. By some means, although, Biden thinks that he can mollify Individuals’ issues about China with vapid feedback masquerading as powerful speak.
WATCH FULL VIDEO HERE:


Although AMD makes some of the best graphics cards, they’ve been much less competent than Nvidia GPUs for streaming. Nvidia GPUs have almost always offered better encoding performance and extra features absent on AMD cards. It’s one of the reasons why I’ve decided to switch to Nvidia graphics despite being a longtime fan of AMD; I just don’t want to give up a good streaming experience.
But all that might be different now thanks to two key updates to AMD software: a brand new encoder and AMD Noise Suppression, which are competitors to Nvidia NVENC and RTX Voice. I tested out AMD’s new tools and the results make me think switching to AMD is a possibility now.
When it comes to streaming, it’s crucial to have a good encoder, and if you’re streaming games you’ll probably want to use GPU encoding rather than CPU encoding. Not only does Nvidia’s NVENC encoder have good quality, but it also doesn’t use very much data, which is crucial for streaming. You want the best ratio of visual quality to data usage possible, and in this area, Nvidia’s encoder was far ahead of AMD’s. But now that the latest version of AMD’s encoder AMF is finally out, I think Nvidia has lost this advantage.
The above image is from the opening shot of 3DMark’s Time Spy benchmark, which I recorded using streaming optimized settings at 6000Kbps. I selected this specific part because there’s lots of foliage, which is often difficult to capture with good quality (especially when there’s very little data to go around), but as you can see the difference between AMF and NVENC is essentially nonexistent. AMF did well in the rest of the benchmark as well, and you wouldn’t be able to tell the difference if the two recordings weren’t labeled.
It’s especially important that AMF was able to achieve this using the same bitrate that NVENC was using. It would be pretty pointless if AMF looked good but needed a substantially higher bitrate to compensate. Twitch, arguably the most popular game streaming platform, only allows up to 6000Kbps, which is a very small amount of data to work with. With respect to recording, each video was only about 3 minutes long and each was about 100MB, which is really good for people who upload unedited stream VODs to YouTube for archival purposes.
That being said, only AMD GPUs based on the RDNA2 architecture (which includes RX 6000 series GPUs) can take full advantage of the AMF encoder because older GPUs don’t have support for B-Frames, which help to increase image quality. This is a limitation of the hardware, not the software, so your RX 5700 XT will never be quite as good as an RX 6950 XT for streaming.
What AMD really needs to focus on in the future is updating its encoder just as often as Nvidia. The newest version of AMF was done and just sitting as open source software until Open Broadcast Software contributors finally added it to the app, and now we have to wait for all the streaming services to update so you can use the new encoder. I’d like to see AMD assume as active of a role as Nvidia has in this area, not just when it comes to making updates but also distributing those updates.
Audio quality is an important (and sometimes neglected) part of streaming, and here too Nvidia held the edge thanks to its RTX Voice software, which is basically an AI-enhanced noise gate. AMD is catching up in this area with its new Noise Suppression tool, which is supposed to do the exact same thing as RTX Voice.
Given that AMD GPUs have no AI acceleration features like Nvidia GPUs, I was skeptical that Noise Suppression would be any good. Much to my surprise, the results were quite good: my gaming keyboard was nearly inaudible, even while I was talking, and the quality of my voice wasn’t reduced. If I switched to AMD Noise Suppression, I don’t think anyone that watches my streams would be able to tell the difference.
But did AMD GPUs even need this feature? Why not just set a noise gate in OBS? Well, the problem with noise gates is that they can only work based on volume, and background noise can get quite loud, especially the clicky noises from gaming keyboards. RTX Voice is a critical part of my streaming setup because it can intelligently separate my voice and my keyboard. Now that AMD GPUs have the same exact functionality, I can actually consider streaming on AMD hardware, like my ROG Zephyrus G14.
I also like that AMD’s Noise Suppression is built into the Radeon driver suite, whereas RTX Voice is only usable by installing Nvidia Broadcast. Not only is AMD’s solution more simple, but it’s also more reliable. I can’t tell you how many times I started my stream just to realize my mic audio wasn’t coming through because Nvidia Broadcast was closed for some reason. Nvidia could learn much from AMD when it comes to driver suites, not just for this specific feature but in general.
But I do have quite a bit of criticism for AMD here when it comes to support. Not only does Noise Suppression require an RX 6000 GPU, but it also requires a Ryzen 5000 CPU or newer. The CPU requirement in particular is frustrating and almost certainly arbitrary. Not only does it lock out users running older versions of Ryzen (most of which are still fast enough in 2022), but it also excludes everyone that uses an Intel CPU. It’s impossible to justify this requirement when some of the best CPUs available today are made by Intel.
Having finally bridged the gap in video and audio quality features, AMD GPUs are finally as capable as Nvidia GPUs for streaming in the most important areas. While the level of support AMD offers leaves much to be desired, with current generation AMD hardware you can stream games with the same kind of quality you’d see from an Nvidia-powered PC. There are some other features that Nvidia offers, such as a digital green screen for webcam users, but AMD doesn’t really need to offer the same feature when third-party software can do the same thing.
AMD’s focus right now should be ensuring it never falls this far behind ever again. AMF was worse than NVENC for several years, and RTX Voice has been around since 2020. Technology is always a moving target, and it’s hard to see Nvidia resting on its laurels any time soon. In order to compete with Nvidia, AMD can’t just rely on open source software and hoping someone makes something. AMD needs to do that itself.
- Why I’m feeling hopeful about Nvidia’s RTX 50-series GPUs
- I’m worried about the Nvidia RTX 4080 Super
- After decades of Windows loyalty, I’m switching to Mac
- Nvidia and AMD GPUs work together better than you might think
- I’m a laptop reviewer. Here’s why I still use a laptop from 2021


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On January 25, 2022, the Antioch City Council approved a permanent ban on oil and gas drilling, production, and exploratory operations within city limits, extending its track record of enlightened protection of city residents. Antioch is one of the most diverse cities within the Bay Area, with a 2020 population that was 33.2% Latinx, 27.8% White non-Latinx, 2l.5% Black, 11.7% Asian, and 5.8% mixed race or other. Preventing fossil fuel activities within Antioch is a victory for environmental justice, as well as ensuring public health and maintaining property values.
Antioch is considering another fossil-fuel related issue: whether to extend the permit allowing a pipeline that currently transports natural gas and other hydrocarbons on city streets to the Chevron refinery in Richmond. At issue is the risk to public health and the environment in case of a pipeline rupture. A motion of some council members at the September 28, 2021 meeting to approve the permit failed. Brentwood previously denied a permit extension to the portion of the pipeline going through that city. Your written comments and verbal testimony supporting permit denial are needed the next time it comes up for a vote. This may be as early as the next council meeting; we’ll let you as soon as we know.
A 50-year-old plugged oil well in unincorporated Antioch is being allowed to restart operations as an injection well without public review or an Environmental Impact Review (EIR). CalGEM, the California Geologic Energy Management agency, made this dangerous and contradictory decision on the basis that the well is part of a nearby active drilling site. The contradiction is that Dozier-Libbey High School, the Kaiser Antioch Medical Center, and pending senior housing all are within the 3,200-foot setback limit that CalGEM itself is proposing for new fossil fuel drilling sites. The danger is that the numerous plugged and abandoned wells all over east Contra Costa could be reactivated without public review or an EIR, based on this precedent. Sunflower Alliance is filing a lawsuit against CalGEM because of the widespread and dangerous consequences of this decision. Please go to Help Support Our Lawsuit Against CalGEM! to learn more and donate to defray legal costs.
Opposition to proposed oil drilling in an unincorporated area a few 100 feet from Brentwood homes continues to grow. To recap this movement’s history, the county Board of Supervisors approved the permit application in 2020 without an EIR, causing residents and environmentalists to demand that a thorough impact study be carried out. The EIR is still pending public comment; we’ll let you know when the comment period opens.
The petition urging the Contra Costa County Board of Supervisors to ban new oil and gas drilling is gaining signatures. If you haven’t signed yet, please go to No New Oil and Gas Drilling in Contra Costa! – Action Network and add your name. Petition sponsors are half-way to their 5,000 signature goal for presenting the petition to the Board and need your help.
Newly published research identifies the adverse health impacts of low levels of particulates for older adults. The Health Effects Institute, an independent research institute jointly funded by the EPA, industry, and foundations, released the results of their study of the medical records of 68.5 million older Medicare recipients for the years 2000 to 2016 on January 26, 2022. The research found that long term exposure to even low levels of air pollution was correlated with excess mortality. The current national standard for PM 2.5, the tiny particulates in polluted air that are most damaging to health, is 12 micrograms per cubic meter; lowering the permitted level to 10 micrograms per unit would have reduced deaths by more than 143,000 over the study period. The association of low-level pollution and increased mortality, primarily from cardiac disease, was particularly strong in rural areas with less access to health care and lower incomes. This study will inform the EPA’s review of the PM 2.5 maximum acceptable level that is due this spring and hopefully will result in a tightened standard. Most health experts believe there is no safe level of PM 2.5 pollution.

domain: law


The North Carolina State Bureau of Investigation may move from the Department of Justice to the governor’s office. If you recall from past posts, one of the criticisms of the SBI — especially following the News & Observer’s report about the questionable practices in the crime lab’s handling of evidence — has been that it is not independent of the state’s law enforcement arm. What strikes commentators as odd about this proposal is that it is part of the Senate budget bill.
According to Sen. Thom Golsby, R.-New Hanover, the move is about saving money, not about the relationship between prosecutors and the state’s forensic experts. By putting the agency under the direct supervision of Gov. Pat McCrory, the state would save on training and administrative costs.
In a nod toward creating a more independent agency, the proposal does call for a change to the appointment process for the director. The governor would appoint the director, and the General Assembly would confirm the appointment. The director would serve a 10-year term, but not at the pleasure of the governor: Once the director is confirmed, the governor would not have the authority to fire him or her.
Not everyone warmed to any of part of the proposal. Opponents — and the opposition tends to run along party lines — expressed their concerns that the governor would be in charge of the very office charged with investigating corruption in state government.
Opponents noted as well that the move would effectively combine the operations of the SBI and the Department of Public Safety, which also reports directly to the governor. According to the DPS website, the department secretary is “the sole representative on the Governor’s Cabinet for the state’s law enforcement, correction and emergency response community.”
Finally, critics assert that cost savings would likely come from staff cuts — “consolidating positions.” The SBI is already short-handed, so it is unlikely that any cost savings would improve the agency’s efficiency or effectiveness.
Source: WRAL, “Proposed SBI move controversial,” Mark Binker, May 29, 2014


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You can listen to this audiobook in formats: AIFF, MP3, FLAC, WAV, MPEG4, WMA (compression ZIP, RPM, DEB, BZ2, RAR)
Total pages original book: 272
Includes a PDF summary of 21 pages
Duration of the summary (audio): 15M47S (4.2 MB)
Description or summary of the audiobook: The Best 'Then and Now' Bible Atlas Ever It has Features No Other Has! 120 stunning detailed Bible maps Clear plastic overlays of modern cities and countries so you know where Bible places are today. Incredible insights into the lives of 30 important Bible characters. This atlas focuses on people not regions - and how the geography affected their lives and decisions. For example: Know how David's clever understanding of geography and politics led to his marriage with Ahinoam of Jezreel. Discover why Naomi, in the Book of Ruth, couldn't just move back to Bethlehem after her husband's death and use his land again. Find out why Moses and the Children of Israel took the long southern trek from Egypt to the Promised Land, rather than the direct route. This atlas gives you incredible insights into your favorite Bible stories. See the Table of Contents at the bottom.
Other categories, genre or collection: Historical Maps & Atlases, Biblical Studies & Exegesis, Guidebooks
Download servers: Google Drive, BitShare, MEGA, iDope, Dropbox, IsoHunt, Hotfile. Compressed in ZIP, RPM, DEB, BZ2, RAR

domain: geography


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|Definition||:||Cheam railway station|
|Category||:||Transport & Travel » Railway Station Codes|
What does CHE mean?
Cheam railway station (Stataion code: CHE) is a railway station in Cheam London Borough of Sutton, England, United Kingdom.
|Sort By:||Popularity||Alphabetically||Filter by:||Country/Region:||Category:|
Frequently Asked Questions (FAQ)
What is the full form of CHE in Station Codes (UK)?
The full form of CHE is Cheam railway station

domain: travel


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I have had one board in my shop for 3 years. When I bought it it was with a bunch of other lumber that an older gentleman had, and really didn’t look like it was the pick of the litter. The walnut I bought was all clear, and was used rather quickly. But this piece still remained. I would look at it now and again, wondering what I was going to turn it into, maybe a shelf or shop fixtures.
Then, I was reorganizing the stacks of lumber, and had a few minutes. My curiousity got the better of me when I took a closer look at the dirt, grime and greyout on the surface. Just barely visible were some wavy undulations, with some hints of figure. Thinking I might as well break into the board and find out what sort of figure it had, I started milling it down.
I use a lot of poplar. It is one of my go-to woods for basic cabinetry, jigs, fixtures and shop furniture. I have never had a piece of poplar with this much figure to it though. Sure, a little bit around a knot, or some in a crotch, but never this much, consistent throughout the board. I knew it had to go into something a bit more specialized.
After careful consideration and some failed attempts to get another wood that it would match up with, I decided that a pair of Moxon style vises would be the best use for this particular board.
Small Moxon Vise: $300
(Shipping $20 to the USA)
8.75" between screws, 4.5" clamping depth, 7" tall chop, 27" long overall, Kentucky Coffee Bean Screws
Large Moxon Vise: $350 (Shipping $25 To the USA)
17" between screws, 4.5" clamping Depth, 7" tall chop, 34 7/8" long overall, Beech Screws

domain: hobby


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The Ontario County Humane Society says that on September 8th a Canandaigua man was arrested for abandoning a dog, which had just been adopted.
Timothy M. Morgan, 37, of Canandaigua was charged with animal abandonment, after it was determined he left a dog named Bella loose on Straw Road – after unsuccessfully returning the dog to an area-shelter.
When that shelter could not accept Bella, he let the animal loose on Straw Road, forcing it to fend for itself.
After re-collection, the animal was placed up for adoption.
The Ontario County Sheriff’s Office assisted, according to the Humane Society.

domain: news


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Should ecosystems and its services be valued? This question is foremost in the minds of conservationists today with the current debate on rhino horn and ivory and the trading thereof. This Guardian article comes to the conclusion that we have no choice but to so. The emotional approach has failed over the last 25 years and we have to follow a new approach if we are going to win this war.
This is however but a small part of the global discussion, where the identification of the important of ecosystem services has been increasing and the watershed study by De Groot and others on the value of global ecosystem services makes this very clear. Ecosystems and the services they provide have a capital component. It also indicates that payment for these services has to be included in government policies if rural communities are to derive benefit. Communities should be rewarded for the management they can provide.


|Flange Width||350 mm|
|Fuel Consumption Range||8-18 kg/liter|
|Stirrer Motor Speed||960 RPM|
|Outlet Valve Size||40 mm|
|Stirrer Motor Power||5.0 HP|
|Inner Diameter||150 mm|
|Outer Shell Diameter||1900 mm|
In order to make quality of lead suitable for its different uses, different variations of pot melting processes are employed. These include – “Re-Melting” for removal of slag, Refining Pot for attaining required purity levels and “Alloying” for producing various alloys of lead. The equipments used are the same, the consumables and the processes. The Refining Pot for Lead recycling (or Melting Pot or Alloying Pot, as it is variously called) is a mechanical mixing device with a pot and a heating arrangement. The inner pot is made of heavy MS plate with dish end bottom. It is placed within a jacket of refractory bricks, which in turn, are protected by an outer cover of MS plate with reinforcements. The pot is covered at the top with opening for feeding lead ingots and is provided with an electro - mechanical mixer. At the bottom, a heating source, usually an oil fired burner, is provided to heat the pot and to melt the lead.


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Cheesy chicks: Woman takes top US cheese prize second year runningChampionship Cheese ContestcheeseMarieke Gouda
Not all fights for recognition in predominantly male fields make headlines, but that doesn’t mean we’re not going to applaud them when they do, and tradition is getting a run for its money on the farms of Wisconsin.
Despite only making up a tiny percentage of cheesemakers in the United States, Marieke Penterman of Holland’s Family Cheese in Thorp, Wisconsin and her Marieke Gouda grabbed the top prize at the U.S. Championship Cheese Contest, which took place at Lambeau Field (of course). She is the second woman in a row to be crowned champion and has only been in the biz for six years.
Her response can’t help but bring a smile to your face, either:
Marieke was on hand to accept the award, and for the first time in her life, said on stage she was “speechless.” She did recover afterward, doing her signature “happy dance,” walking through the crowd and accepting hundreds of well wishes from a crowd that had gathered to taste some of the best cheese in the country and watch the final round of judging.
“Can you believe it?” Marieke told me after the festivities had died down, the media had left, and just a handful of industry oldies were nursing their drinks. “The best in the nation. Wow. I can’t wait to tell my dad.”
Here’s to pioneering women in every field, and you can visit her website to either find a local store that stocks this god(dess)ly gouda or order online.
Full story at Cheese Underground.
All about cheese.
Posted by Kate Rinsema


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Strictly Come Dancing has seen not one, but two competitors forced to pull out the competition this evening as Will Bayley and Neil Jones both suffered leg injuries this week. However, as Neil’s injury happened just hours before the show, pro Kevin Clifton stepped in as he joked he had to "get in the final one way or another."
Kevin was knocked out in the third week of the competition with partner Anneka Rice, after the pair failed to impress in Movie Week with their Kill Bill inspired Charleston.
However, Kevin was back unexpectedly this week, as he stepped in to replace Neil very last minute.
And, as he joked that he would use the opportunity to get to the final, fans on Twitter slammed the pro.
“Urgh, gotta see #KevinClifton this week #StrictlyComeDancing,” said one.
Strictly Come Dancing 2019: Kevin Clifton slammed by fans over final remark
Another unimpressed viewer shared: “Thought I was rid of Kevin Clifton for the next ten weeks.”
“She deserved those nines for having to put up with Kevin,” joked a third.
“Wouldn’t it be terrible if Kevin got eliminated TWICE in one season… #Strictly” said another in jest.
After their performance, Kevin gushed over Alex’s strength as she taught him the routine incredibly close to the start of the show.
“Having to teach a professional how to teach the dance in about 45 minutes, everyone can see I made a few mistakes in that,” he commented.
Host Tess Daly vouched for the pair, as she said: “It genuinely was about 45 minutes!”
Craig told Alex: “I thought [Alex] did very, very well, the story really suits your compact body… congratulations.”
Shirley also praised Alex, as she commented: “I don’t really want to talk about the dancing, I want to talk as an ex-competitor myself."
Strictly Come Dancing 2019: Anton Du Beke makes show first [STRICTLY]
Strictly Come Dancing 2019: Karen Hauer suffers wardrobe malfunction [PICTURES]
Why is Will Bayley not dancing on Strictly Come Dancing tonight? Ho... [WILL BAYLEY]
Others, including former pro James Jordan asked why pro Gorka Marquez hadn’t been asked to step in.
James, who is well known for live tweeting his thoughts on the show, shared: “Shame they didn’t use Gorka to step in for Neil… #Strictly."
“You couldn't have got Gorka instead of Kevin? #Strictly,” asked another.
“Kevin has kindly stepped in HAVE YOU FORGOTTEN GORKA EXISTS #Strictly,” questioned a third.
However, the pair were praised by judges for their quick thinking.
Shirley told Alex: “The mental ability you had today to switch partners an hour or half an hour before the show… I thought it was absolutely on point."
Kevin admitted he made mistakes in the routine, as he confessed: “I completely blanked in the middle!
“We did what we did, the show must go on, it can go one way or another!
“I literally went out in the middle of the routine and got the whole routine wrong, you carried me through it Alex,"
She received her highest score yet, as the judges awarded the pair 34 points - will she make it through to next week?
Strictly Come Dancing: The Results returns on Sunday at 7.15pm on BBC One.

domain: celebrity


Iggy Azalea Gets Vulnerable On A Remix Of Total Ape’s “In A Haze”
Iggy Azalea is on an undeniable hot streak lately. After hitting countless roadblocks over the last few years, the Aussie rapper leapt over them all with the release of her Survive The Summer EP. She returned to the Billboard Hot 100 with the project’s lead single, “Kream,” and landed a viral video in the process. Just this week, the “Fancy” hitmaker announced plans to hit the road with fellow rap queens CupcakKe and Saweetie. We’re still waiting for more finite details about the aptly titled Bad Girls Tour. But in the meantime, she just added another win to her growing list.
Today (September 7), I-G-G-Y linked up with Swedish production duo Total Ape on a remix of “In A Haze.” This brings a close to a lengthy saga that has unraveled over the past year. In 2017 Iggy worked on the track after Camila Cabello passed on it for her debut album. Although it became a fan-favorite after it appeared online, it was ultimately cut from Survive The Summer. But it all worked out in the end. Iggy’s version of the song now serves as the lead single and title track for Total Ape’s just-released EP. Appearing alongside collaborations with Nico & Vinz, K Stewart and Karol G, it highlights a side of her musicality we don’t often see.
Over a hazy production, the siren gets vulnerable as she attempts to settle into a relationship. “I been caught up in you and the things you doing. And I can’t lie to ya, I don’t even mind,” she raps on the opening lines. “I been tryna get used to how fast life been moving. And looking for something outside this money to call mine. Tell me, tell me, tell me maybe could you be that?” It is a far cry from the outrageous beats and braggadocios verses on “Hey Iggy.” However, this is equally welcome. Hopefully, the trio can get together to release a music video and potentially plan a few performances. If so, I can see this being their next big hit.
Give the track a listen and check out the rest of In A Haze below!


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This post is called Panasonic 50 Cfm Bathroom Fan With Light. You can download all the image about home and design for free. Below are the image gallery of Panasonic 50 Cfm Bathroom Fan With Light, if you like the image or like this post please contribute with us to share this post to your social media or save this post in your device.
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domain: design


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A bunion is an enlargement of the base joint of the toe that connects to the foot, often formed from a bony growth or a patch of swollen tissues. It is caused by the inward shifting of the bones in the big toe, toward the other toes of the foot. This shift can cause a serious amount of pain and discomfort. The area around the big toe can become inflamed, red, and painful.
Bunions are most commonly formed in people who are already genetically predisposed to them or other kinds of bone displacements. Existing bunions can be worsened by wearing improperly fitting shoes. Trying to cram your feet into high heels or running or walking in a way that causes too much stress on the feet can exacerbate bunion development. High heels not only push the big toe inward, but shift one's body weight and center of gravity towards the edge of the feet and toes, expediting bone displacement.
A podiatrist knowledgeable in foot structure and biomechanics will be able to quickly diagnose bunions. Bunions must be distinguished from gout or arthritic conditions, so blood tests may be necessary. The podiatrist may order a radiological exam to provide an image of the bone structure. If the x-ray demonstrates an enlargement of the joint near the base of the toe and a shifting toward the smaller toes, this is indicative of a bunion.
Wearing wider shoes can reduce pressure on the bunion and minimize pain, and high heeled shoes should be eliminated for a period of time. This may be enough to eliminate the pain associated with bunions; however, if pain persists, anti-inflammatory drugs may be prescribed. Severe pain may require an injection of steroids near the bunion. Orthotics for shoes may be prescribed which, by altering the pressure on the foot, can be helpful in reducing pain. These do not correct the problem; but by eliminating the pain, they can provide relief.
For cases that do not respond to these methods of treatment, surgery can be done to reposition the toe. A surgeon may do this by taking out a section of bone or by rearranging the ligaments and tendons in the toe to help keep it properly aligned. It may be necessary even after surgery to wear more comfortable shoes that avoid placing pressure on the toe, as the big toe may move back to its former orientation toward the smaller toes.

domain: medical


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Original artwork - coloured inks on white paper. Acrylic framed with brushed silver border (560mm x 740mm).
This artwork is about releasing your inner warrior and standing in your own power .
'Releasing the Inner Warrior'
Original artwork includes description as follows:
"We all hold back at times because we doubt our strengths. This is all about our inner warrior and how we can use him to move forward in life."
If you are not 100% satisfied with your purchase, you can return the product and get a full refund or exchange the product for another one, be it similar or not.
You can return a product for up to 30 days from the date you purchased it.
Any product you return must be in the same condition you received it and in the original packaging. Please keep the receipt.

domain: artistic


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Raw Food Diet
Get the lowdown on kelp noodles, a pasta alternative and raw-food favorite made from iodine-rich seaweed.
The Raw Food Diet
What is the raw food diet? What are the benefits and guidelines of the diet? What are the possible safety concerns?
What Foods Can I Eat on the Raw Food Diet?
A list of foods that can be eaten on the raw food diet.

domain: food


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5001 Wood Panel Square - Architecture - Hollywood Series - Chinese Theater
5001 Wood Panel Square - Architecture - Hollywood Series - Chinese The
Artist-Made Wood Panel Prints: Square
Wood mounted prints are made with birch-ply panels, acid-free paper and UV-blocking coatings. All Wood Panel Prints are hand-made by the artist and signed on the back. Original artwork by Mark S Brunner of LA.CA.US.
* Square sizes are 4x4", 6x6", 8x8", 12x12", 24x24", 36x36".
* Large sizes 24x24" and 36x36" come with hanging wire installed on the back.
* 1 5/8" thick, gallery-quality panels made in USA.
* Hand-painted sides, dark brown color.
* Easy to hang on wall or display on shelf / table.
* Watermark text / logo on online art images is not present on the products.
* Pictures of artwork are as color-accurate as possible, but please be aware that the color in the photos may be slightly different than the actual product.
* All artwork & graphics are protected under international copyright laws and can not be reproduced or distributed in any manner without permission.


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plork and way
The past weekend has been about work, work, work. Fortunately, there were some moments of respite and fun, which I thankfully managed to capture in pictures. Yay!
Photos from Portrait Day, organised by Organisation of Illustrators Council specially for Noise Singapore. The boy in the first photo was our first model of the day.
I love how each artist has a different style and choice of medium and different way of capturing your essence in their work.
We’re doing this again this Sunday from 3-6pm! I might just do it, it’s so fun and you can get your artwork of choice for only $10, which goes to the artist. Such a lovely concept by OIC.
Fishman. Artwork by ANTZ.
Wall of free expression. The one that says Meow is by me!
Dinner buffet with the family on Sunday at Furama Cityfront Hotel. First time wearing my Where The Wild Things Are dress.
This was taken today, a goofy kind of photo.
And that pretty much sums up my weekend. I have two days of leave starting tomorrow which I haven’t decided how I will spend, but I’m hoping to wander around the island a little bit and take photos, so here’s to that!
I’m hoping to do a few things this coming weeks which I’ve always wanted to do but never did.
This includes catching a movie by myself, yep I’ve never done it before! I can do lunches alone but somehow could never go to the movies alone…let’s see if I make it!
Top 2 photos shamelessly pilfered from the noise temps, the rest are by me (well except the one of erfen and I, of course)


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The export of Swiss products increased by 1.9 per cent in March – still strong, but considerably less than in January and February.This content was published on April 26, 2011 - 11:05
During the first quarter of 2011, Swiss exports went up by 5.8 per cent for a total value of SFr50 billion ($56.88 billion). The growth trend continues despite the strong Swiss franc.
This increase is roughly the same as that in the third and fourth quarters of last year, the Federal Customs Administration announced on Tuesday.
Swiss watch exports did especially well according to figures released by the Federation of the Swiss Watch Industry on Tuesday.
In the first quarter they rose to SFr3.93 billion – and increase of 14.7 per cent in comparison with the same period a year ago.
In March alone, watch exports went up by 11.1 per cent to SFr1.4 billion.
In compliance with the JTI standards


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I’ve web-published a new Introduction and Part One of In the Cells of the Eggplant. Here’s why you might want to read them—or not—and how to read them if you do.
The Eggplant is—or will be—a book about meta-rationality. “Meta-rationality” means improving technical practice through reflection on the relationship between rational systems and their surrounds. You may care about meta-rationality if you want to level up your work in science, engineering, or other fields that make use of formal systems.
I began writing The Eggplant almost three years ago, expecting it could be finished in a few months. Since then, circumstances have left me with little time to write, and I’ve finished only the first two out of five Parts of the book. I can’t guess when (or whether) I’ll be able to finish it. So I’ve decided to post those Parts, after minor tidying, which is now complete for the first.
Part One is mostly not about meta-rationality. Neither are Parts Two and Three. These three Parts explain preliminary concepts you need in order to understand meta-rationality, which the book explains in Parts Four and Five. To cover this extensive background material, none of which is original to me, I would rather refer readers to other sources. Unfortunately, I couldn’t find clear, detailed, accessible explanations elsewhere, so I’ve had to write them myself.
Part One is about rationalism: a mistaken and obsolete, but still often taken-for-granted, theory of rationality. Understanding rationalism’s errors is a prerequisite for understanding meta-rationalism, which includes a more accurate explanation of rationality. Unless you recognize that rationalism is wrong, you are unlikely to seriously consider an alternative. More significantly, specific failure modes of rationalism point directly to specifics of the more accurate understanding.
Reasons not to read Part One (or not yet)
The Introduction to the book overall explains what it is about, and why you might want to read it. Its section on “Is The Eggplant for you?” includes some reasons you might not, too!
There also are good reasons not to read Part One specifically, or at least not now.
First, The Eggplant builds a tall conceptual tower, with layers of concepts depending on previous ones. It might be best to read the whole thing at once, so the foundations are solid as you work you way up to higher stories. On the other hand, Part One makes sense by itself, and might be interesting for its own sake, and who knows when the rest will be available?
Second, Part One is about forty thousand words, or the equivalent of about a hundred and thirty printed pages. It’s my intention to publish The Eggplant as a conventional book eventually. Many readers say they’d rather have it that way than on the web. You may want to wait for a paper edition. On the other hand, if that includes the whole thing, it may not happen for years. I could publish Part One as a slim paperback by itself—but do you care enough about “how rationalism is wrong” to want just that? (Let me know in a comment below.) Or, since Part Two is also pretty nearly finished, and about the same length, the two could be bound together as typical-length book. But, although each stands alone reasonably well, they don’t form a coherent whole. Part Three, offering a better understanding of rationality, is built on Parts One and Two separately, and the first three Parts would make a cohesive package together. But Part Three is not ready. Maybe Parts One and Two could be two separate short books? I’m dithering, and would welcome advice.
Third, if you have built an identity around rationalism, there’s a danger that Part One will drop you into post-rationalist nihilism, which can be awful. You can avoid that if you have something beyond rationality to look forward to, and meta-rationality fits the bill. However, that part of the book isn’t written yet, so the antidote is not available.
I’ve delayed making Part One public until now, out of concern for precipitating post-rationalist nihilism. My hope is that it does more good than harm; but I’ve been going back and forth about this for months.
So, this is a serious request: please do not read Part One now if you are a committed rationalist. If you are curious, wait at least until you can read Part Three (which explains how rationality does work), and preferably Part Four (which explains how to do it better).
Start at the beginning
The Eggplant is not a collection of essays (much less a blog). It is a densely structured book, building up a complex system of concepts, most of which will be unfamiliar to most readers. Every chapter depends on earlier ones to make sense. I recommend beginning at the beginning, and reading forward in order. (Use the Navigation box at the end of each chapter to orient. Somehow, some readers miss that feature of the web site.)
In fact, I recommend starting with the introduction to the book overall, which explains its motivations, sets out some central concepts, and provides an overview.
I did a major revision of the Introduction a couple months ago. If you have read the version that was up on the web for a couple years before that, I’d recommend revisiting it. Much of the material is new. Skip over the bits you’ve already read, of course!
Indeed, when reading any book, skipping ahead is sensible when you encounter material you already know. Some readers may find much of Part One familiar. In that case, you might flip through it, read only unexpected bits, and go on to Part Two. (You are less likely to be able to do that with Part Two, or later Parts. Their sources are not commonly known.)
As with a paper book, it may be best to read The Eggplant within a narrow time slot, so that earlier concepts will be fresh in your mind as you need them to understand later ones. However, I plan to tweet links to one or two chapters per week, and to put those into the RSS/email feed on the same schedule.
Foreshadowings as exercises
Part One might, at first, sound like a polemical attack on an ideology or identity: namely, rationalism. That is not the intention, although I do hope it will loosen rationalism’s grip. The aim in carefully disassembling rationalism is not destruction, but understanding its misfunctioning, and clearing space for a better alternative. Part Three will reuse some of the same pieces, in a different configuration.
Most chapters in Part One explain some particular difficulty rationalism faces, and then sketch briefly how a different understanding can address the issue. Those positive alternatives foreshadow the detailed presentation on Part Three.
Since Part Three isn’t ready yet, I suggest taking each of these foreshadowings as an exercise to wrestle with. Can you figure out for yourself how to expand each hint into a detailed understanding of the issue? I’d suggest reflecting on your experience of both everyday life and of technical work, and consider how the vaguely-drawn alternative might explain them.
(This reflection is the work of meta-rationality itself! That is, meta-rationality just is considering how rationality and mere reasonableness play out in practice, largely by examining specific cases.)
It may help to skip ahead and read “The parable of the pebbles,” which is the only chapter of Part Three that’s on the web so far. It’s a condensed version of the Part’s explanation of merely-reasonable “circumrationality,” which is one main aspect of its explanation of rationality overall.
As I publish this metablog post, all but two of the chapters of Part Two are also finished and published on the web. So you can read most of it now if you want.
Part Two’s function in the book is to explain “mere reasonableness” in general—for example, in making breakfast. That is a prerequisite to Part Three’s explanation of circumrationality: the more specific types of merely-reasonable work we do to make formal rationality work. So, while reading Part Two, I’d suggest keeping in mind the questions “How can this sort of work address the problems rationalism ran into? How would it help make technical rationality function well in practice?”
The chapter on reasonable ontology is probably the most important, and it’s one of the two unfinished ones. You may want to wait for it before starting Part Two. On the other hand, it’s near the end of the Part, and it’s likely I’ll get it done soon—before you get that far. (It’s mostly written, but I have to work out some issues in how it interfaces with Part Three.)
The rest of the book, and Meaningness
The Eggplant was my highest priority for writing from late 2017 up until covid hit. Reflecting on mortality made me feel that it’s more important to go back and finish some of the core Meaningness material.
A couple months ago, I wrote, and web-published, about half of the central chapter of Meaningness, which is “The complete stance.” That’s more important than The Eggplant, I think. Consider reading it instead, or first? If you haven’t already.
I also web-published some bits of the purpose chapter—mostly versions from 2007 that I decided are good enough, even if I’d write them a bit differently thirteen years later.
Then I decided that, since Parts One and Two of The Eggplant were nearly ready to go, I might as well polish them up and web-publish them.
My intention now—after finishing the last bits of The Eggplant Part Two—is to finish the complete stance chapter, and then to write some more of the nihilism and purpose chapters. I’ll concentrate on explaining the antidotes to the confused stances that cause us so much misery. That was the original motivation for Meaningness, and I want to get back to it.
My intention for Meaningness in the mid-2000s was a normal-length book, not the sprawling million-word monstrosity it has grown into. If I get time enough to write, I want to go back to that plan. A normal-length paperback summary introduction to the major themes: perhaps by the end of this year, if all goes very well!

domain: library


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One of the most diverse and exciting rock bands to emerge for a generation, Queens Of The Stone Age have continued to produce a high calibre body of work which has seen them explore everything from whacked out stoner rock, huge metal riffs and even taken influence from folk and blues.
Fans will be thrilled to hear the news that they make their long-awaited return with the release of a new album titled ‘Villains’. In a surprise move, Josh Homme and company have opted to have the record produced by Mark Ronson who is better known for working with the likes of Adele, Lady Gaga and Amy Winehouse.
It features the crazed madness of ‘The Way We Used To’. A four-minute firecracker, the song is a fiesta of insanity which centres around a good, hard and heavy stoner riff like any classic QOTSA track should but with an added bright fizzy pop twist which we can be sure comes from Ronson’s influence. You can check out all the new tracks plus more from their amazing back catalogue when they take over The O2 Arena in London on Tuesday 21st of November. Set your personal reminder with Gigantic right now!
While we get all excited for what they promise to be their best ever album, we take a look at the Top 5 Queens Of The Stone Age singles.
Perhaps the most radio friendly of all their singles, ‘The Lost Art Of Keeping A Secret’ showed a massive creative leap for the band and immediately set the band on course for continued major success following its release in 2000.
Drawing on elements of folk and blues, ‘Burn The Witch’ still retains the unmistakable sound of QOTSA but gives it an added sinister layer creating a truly creepy and unsettling song. The lyrics read like a twisted nursery rhyme, mirroring a witch as they cast a spell upon the listener.
‘Little Sister’ is the dark and seductive single which was the band’s first introduction of gold selling fourth album ‘Lullabies To Paralyze’ and proves that you can never have too much cowbell in a song.
‘Songs For The Deaf’ saw the band joined on drums by none other than the almighty Dave Grohl of Nirvana and Foo Fighters. The platinum certified album included their mega hit ‘No One Knows’ which has become a mandatory track for any rock club or Guitar Hero session ever since.
Feel Good Hit Of The Summer is an unhinged ode of love to a cocktail of narcotics. Simple, effective and straight down the line, there is no messing about with this song as the band recreates their rider requests in the form of a blistering 2.45 track.

domain: entertainment


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Rated 7 out of 10 by 10
Rated 6 out of 10 by RiWk Not What I thought!
I bought this game for my kids PS3 as he loves Ben 10. The Ben 10 Alien Force game was much better and lenghtier. Cosmic destruction has 8 levels and the game can be easily beaten in 2-3 hrs of straight play. You cannot play the ultimate aliens the whole game their is 1 available for each level and it can be played for a few minutes only till the boss is beaten. The regular forms are available along with the new aliens Terraspin, Armadrillo, Water Hazard, NRG, and Amphibian. Overall its a decent purchase for the price, I would have rather waited till it dropped even further.
Rated 0 out of 10 by Zeta Nice Game. Only Rant Though
...Is that you can't play as Kevin and Gwen like you were able to in the very first Ben 10 game. Ben 10: Alien Force. Still, should be really interesting. To use all of Ben's current aliens in their ultimate form. Any fan of the Ben 10 series should check this out.
Rated 8 out of 10 by HAZEEN D3 MAKE ANOTHER GREAT GAME
THIS GAME IS A FUN TWIST ON THE SERIES FOR ANY FAN! THE ALIEN FORMS ARE TRUE AND THEY LOOK NICE AND SMOOTH! THE POWER ARE VERY UNIQUE AND IN ADDITION THE TROPHIES ARE EASY... THIS IS A MUST PLAY FOR ANY D3 or BEN 10.
Rated 0 out of 10 by Hero4Life Awesome! Big fan of Ben 10 games. Four Arms!
From what I have seen the took the last game and capitalized on it. With the quick change and some new characters it looks to be the best one yet.
Rated 0 out of 10 rediculous
my dad' yes my dad loves ben 10 and so do i..this is a must buy because its a family game
Rated 0 out of 10 by theboss3214 awsome
triple awsome = ben 10 ultimate forms
Rated 0 out of 10 by CBCKI Amazing!
Ben Ten is cool. So is this game 100% for sure!
Rated 0 out of 10 by yugioh fan now for ps3
finally they will make one for ps3
Rated 0 out of 10 by CBCKI Cool.
Ben Ten is fun. So will this game.
Rated 0 out of 10 by gummer ben 10
If you were five


Welcome to part 2 of our 4 part series on “Why Organic?” Today I’m talking about the way cotton is farmed and what the current environmental issues are. It takes a 1/3 of a pound of chemical pesticides and fertilizers to make just one t-shirt! Find out why organic cotton is good for you and the planet!
Get notified when new posts come out!
teaganandmack.com is a….


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The CFO of Trafigura just said clearing houses will collapse as “margin call doom loop” goes global.
Last week the commodities sector (oil, petroleum, metals and minerals) saw margin calls worth billions of dollars.
Trafigura Group is one of the world’s top oil and metal traders.
Trafigura has in recent weeks stepped up efforts to seek new funding from beyond its traditional group of bank lenders, according to people familiar with the matter.
And no one is able to meet equity demands.
Let’s break it down together.
Welcome to Franknez.com – we’re seeing something very interesting unfold here as margin calls are triggered and short sellers brace for short squeezes.
Let’s dive right into it!
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“Margin call doom loop” goes global, Trafigura CFO warns
Trafigura Group, one of the world’s top oil and metals traders, has been holding talks with private equity groups to secure additional financing as soaring prices trigger giant margin calls across the commodities industry.
The trader held talks with Blackstone Inc. for an investment of around $2 billion to $3 billion but those talks ended without a deal.
The discussions have been based on raising funding due to several margin calls the commodity industry has been facing recently.
There’s no certainty any of the discussions will progress to a deal, they said. (Bloomberg)
These large companies facing margin calls are having a very big problem meeting demand.
Now, the increase in IM (initial margin) created demands on hedge funds and other investors.
Prepare for short squeezes
Studies have looked at the connection between margin calls and market stress, and most have focused on a margin call “doom loop” in which higher margin requirements force fire sales into an already illiquid market.
This process then triggers more margin calls.
Financial institutions are going to be forced to sell assets, triggering short squeezes in heavily shorted stock.
The Dow Jones and NASDAQ are down today as ‘meme stocks’ are soaring.
AMC is up more than 24%, GME stock 11%, and HYMC more than 45%.
The price runups on AMC and GameStop shows us the stocks are merely getting warmed up.
We know this because of the short interest data (updated daily here).
As more market stress begins to settle, hedge funds will be required to keep up with their margin requirements or be forced to liquidate their positions.
Globally, cash IM (in margin) is typically held by banks.
A bigger short squeeze than Nickel?
Analysts are expecting a bigger short squeeze than nickel to occur which soared more than 250%.
Although nickel is in the commodities sector, the financial system goes full circle.
The banks distribute cash and even bailout companies despite the industry.
“Expect much more commodity volatility, and many more multi-billion margin calls, until eventually the big one is triggered, one which leads to a near default not of the LME but of a far bigger clearinghouse.” ZeroHedge.
The liquidity issue in the commodity sector could threaten broader financial stability and create broad liquidity squeezes.
Trafigura’s chief financial officer warned that the spike in capital needed to keep commodities flowing around the world since Russia invaded Ukraine would squeeze smaller trading houses out of the market.
Bloomberg reported that trading houses have been seeking funds to maintain their physical and derivative positions as prices of everything from natural gas to metals soar.
Since commodities represent the basic building blocks of all products in an economy, the prices of commodities affect the operational costs of corporations.
This in turn affects prices in the stock market, further sparking margin calls in this sector.
What will happen as clearing houses require more liquidity?
Leave a comment below.
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domain: economics


Great excitement at the Peugeot stand – here at Geneva Motor Show 2013 – the press conference scheduled even at the dawn of the first press day drew the attention of those who wanted to see the new Peugeot 2008, the French proposal for the compact crossover class.
Peugeot has brought at its stand in Geneva an extremely important model for the brand’s history. It is called Peugeot 2008 and, as the name suggests, is based on Peugeot 208. The French manufacturer wanted to make sure that everyone sees up-close the new 2008, so they studded the stand with many SUV copies. The most popular of these was an orange one, unfortunately restricted by a glass wall. For Peugeot, the stakes are extremely high, because 2008 has the mission to steal from the Nissan Juke’s clients, the segment’s standard.
Geneva Motor Show 2013 Live: Peugeot 2008 photo gallery
Peugeot 2008 Live at Geneva Motor Show 2013
Inspired by the success of 3008, the French are testing a new segment with the small Peugeot 2008, the off-road version of the already popular 208 model. Developed to be a global model, the new proposal for the B-segment measures 4.16 meters (163.8 in) long and proposes an off-road approach to the popular sub-compact.
A declared rival for Nissan Juke and Opel Mokka, the new Peugeot 2008 comes with a new aesthetic approach dominated by protective plastic moldings, a slightly higher ground clearance and a more generous wheel arches. The aluminum lateral trims are not missing and neither the 17-inch alloy wheels, which can be replaced with special ones for rough terrain.
The front look is all Peugeot design philosophy, to which they added nine LED lights and a grid. Glazed surface is complemented by a panoramic roof, while the back is dominated by LED lights and roof anchor bars. The new Peugeot 2008 has as standard a 7-inch touch screen, head-up display, six airbags, traction control and electronic parking brake.
Peugeot 2008 will be animated by the already anticipated engine range: e-HDi diesels and the new generation of three-cylinder petrol engines. So, under the bonnet it will have the three-cylinder 1.2 VTi with 84 hp, the 1.4 VTi with 96 hp, the 1.6 VTi with 122 hp, the 1.6 THP with 158 hp and the 1.4 HDi with 71 hp and the 1.6 e-HDI with 93 hp or 113 hp. Thanks to these efficient units, Peugeot 2008 will ensure low CO2 emissions, with values from 98 g/km. Fuel economy can be as high as 61.8 MPG Imp.
Peugeot 2008 will be produced in three plants of the French manufacturer: Mulhouse in France, Wuhan in China and Porto Real in Brazil. Peugeot 2008 can be ordered at the UK dealerships starting May and it will be officially on sale later this summer.
“Creating the 2008 was a great challenge but we had a very precise idea of the vehicle that we wanted to offer customers. The style brought to life in an early phase did not require any major modifications up until production. The very first sketch was perfect”, says Eric Dejou, 2008 Design Manager.
Agnès Tesson Faget, 2008 Product Project Manager, said: “We wanted to create an exceptional on board space for our customers which takes care of all the occupants and offers them new sensations. The unique ergonomics of the instruments and controls, the careful choice of materials, the quality of assembly, the light ambience … the 2008 stimulates the senses.”
Eric Tomietto, Stop&Start Project Manager, said: “Stop&Start allows the 2008 to offer excellent fuel economy and low CO2 emissions while retaining a high level of driving pleasure. The six engines fitted with this system start with CO2 at only 98g/km for diesel and 99g/km for petrol.”
Peugeot 2008 Video – Geneva Motor Show 2013 Live
Peugeot 2008 via Peugeot stand at Geneva Motor Show 2013


text: Find Patio Builders Near: Newberg Dundee Patio Builders Sherwood Patio Builders Saint Paul Patio Builders Lafayette Patio Builders Dayton Patio Builders Donald Patio Builders Beaverton Patio Builders Wilsonville Patio Builders Aurora Patio Builders Tualatin Patio Builders Local Results for Patio Builders Garden Comforts 125 S Elliott RdNewberg, OR 97132 View Phone Click to View Phone 503-538-5561 George & Gabe Pro Fencing-Deck 22800 SW Jaquith RdNewberg, OR 97132 View Phone Click to View Phone 503-628-5677 Conrad Lumber Company 6.3 Miles Call today! 13025 SW Tualatin-Sherwood RdSherwood, OR 97140 View Phone Click to View Phone 503-625-7535 Knife River Corporation 6.3 Miles 12000 SW Tonquin RdSherwood, OR 97140 View Phone Click to View Phone 503-360-0668 Archadeck of West Portland 6.3 Miles Call Today for a Free Consultation 15880 SW Tualatin StreetSherwood, OR 97140 View Phone Click to View Phone Products and Services 503-925-8756 Don't Know Who to Call? Searching for a qualified patio builder in your area? Call Us for Assistance: 1- Return to First-Page Patio Builders Unfortunately, no results were found for your request. Please try again.


text:
Next Episode of Iron Road is
not planed. TV Show was canceled.
Iron Road follows the journey of Little Tiger (Sun Li), a child whose quest for her long-lost father takes her from a fireworks factory in China to a remote construction camp in the Rockies. Lured by the myth of 'Gum San' - Gold Mountain - she and her countrymen come to Canada by the thousands to do the back-breaking work of blasting through the mountains to lay track. She soon learns that railroads only bring fortune to the few and that every mile of track is purchased with fear and death. As treachery and prejudice threaten her, Little Tiger must use her wits and courage to fulfill her quest and honour her friends who died in this foreign land.
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text:
A charitable donation of 400 cabin blankets and 150 crew sleeping bags, have been transported to Kenya courtesy of IAG Cargo
IAG Cargo peak volumes out of the Indian market have so far outperformed expectations.
IAG Cargo has launched the start of a new Paris Orly to Newark New Jersey route, its first ever direct cargo route between France and the USA.
IAG Cargo has today announced that it will be launching a new route to New Orleans, Louisiana, from March 26, 2017
London Gatwick services to Fort Lauderdale and Oakland to launch in 2017
IAG Cargo has today announced its Q2 2016 results, reporting commercial revenue of €241m over the period from April 1 to June 30, 2016
Lynne Embleton, current British Airways Managing Director at Gatwick, is to become Chief Executive of IAG Cargo with immediate effect
IAG Cargo has today announced the launch of its new freighter service between Madrid and Basel. The new route has been introduced to meet the demands of Switzerland’s fast growing pharmaceutical sector.
IAG Cargo has today announced its Q2 2017 results, reporting commercial revenue of €260m over the period from April 1 to June 30, 2017, an increase of 7.6 per cent on 2016 at constant exchange.


The need for an analytical method that one can apply manually to estimate dynamic impact forces on railway tracks that occur because of varying track stiffness or track profile initiated a study to develop an analytical method named as the Bezgin Method. The advancement of this method presented in this paper includes an extension of a set of equations developed and introduced by the first author earlier as the Bezgin Equations using the proposed method and development of a new equation. In addition to track stiffness taken into consideration in the equations introduced earlier, the Extended Bezgin Equations presented in this paper take into account bogie stiffness, wheel spring stiffness, Hertzian contact stiffness, and a factor for damping. The new equation takes into account the effect of vertical wheel acceleration as a train transitions to a stiffer structure or transitions along an ascending track profile. The paper unites and applies these equations to estimate wheel forces that develop along stiffness transition zones by considering an array of train speeds for an array of track stiffness ratios and representative values for track profile deviations along the transitions. Final section of the paper includes elaborate finite element analyses of structural track models that involve transitions of soil supported ballasted railway tracks with concrete based ballasted tracks along various transition lengths and compares their estimates for dynamic impact force factors with those estimated by the Extended Bezgin Equations. The paper concludes with a discussion of the potential uses, benefits, and the value of the Bezgin Method for railway engineering.


Toronto artist, ShaqIsDope, released his anticipated mixtape Black Frames a few days ago. The 12-track project is featureless till you get to the bonus track “Bow My Head” with a verse from West9 Phamily. The project is about his self examination and the experiences Shaquille Baptiste has faced thus far in his life.— Stream his new mixtape below. — ShaqIsDope will be performing some of the tracks off Black Frames opening for Ty Dolla $ign today at the Toronto Opera House. — Don’t forget to watch his music video for “DWNTWN” here.
Follow Daily Loud’s official soundcloud page: soundcloud.com/dailyloudsounds


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4 декабря 2018 г.
Today, we are announcing the general availability of Azure Stream Analytics (ASA) on IoT Edge, empowering developers to deploy near-real-time analytical intelligence closer to IoT devices, unlocking the full value of device-generated data.
29 октября 2018 г.
We are excited to announce that live data local testing is now available for public preview in Azure Stream Analytics Visual Studio tools.
15 октября 2018 г.
Azure Stream Analytics is a fully managed service for real-time data processing. Stream Analytics jobs read data from input sources like Azure Event Hubs or IoT Hub. They can perform a variety of tasks from simple ETL and archiving to complex event pattern detection and machine learning scoring.
11 октября 2018 г.
Azure Stream Analytics is Microsoft’s serverless real-time analytics offering for complex event processing. It enables customers to unlock valuable insights and gain a competitive advantage by harnessing the power of big data.
15 ноября 2017 г.
Today, we are announcing the public preview of Azure Stream Analytics running on Azure IoT Edge. Azure Stream Analytics on IoT Edge empowers developers to deploy near-real-time analytical…
25 сентября 2017 г.
Today at Microsoft Ignite, we are pleased to announce the preview of several new and compelling capabilities in Azure Stream Analytics. These include built-in inline machine learning based anomaly…
7 сентября 2017 г.
Over the past decade very few industries have experienced the pace of transformation as much as the retail sector. Driven by competition from innovative online merchants, traditional retailers are…
12 октября 2016 г.
Today we want to announce that we’ve just added the ability to test Stream Analytics queries in the “new” Azure portal. Here’s a quick look at how this works...
21 сентября 2016 г.
We're happy to announce that Azure Stream Analytics now supports IoT Hub Operations Monitoring giving you an easy way to analyze the operations of your IoT devices.
17 мая 2016 г.
Azure Stream Analytics team is excited to announce Stream Analytics is now ISO 27001, ISO 27018 certified, HIPAA compliant, and in scope for EU Model Clauses.


text:
in each category you will find our patterns
For the first person who sends in a completed pattern of one of our designs, which is not already in the gallery you will receive a free pattern of your choice of the same pdf value, so if it is one of our small $4.95US designs you can choose a free small $4.95 design etc. You can choose to receive a gift voucher for the Artecy Shop instead of a free pattern.
Program Terms and Conditions
- The completed image must be for a design that is not already in the gallery, the only exceptions to this is if we currently have an image that is dark or not very clear and you have a brighter, clearer
image, or a stitcher has used non DMC cottons or a combination and you have used full DMC colours, or they made major changes to a design but you have stitched the pattern exactly as it is etc.
You can email a copy through and we will let you know if it is accepted.
- The pattern you have stitched and are sending the image through for must still currently be available for sale on our www.artecyshop.com website. We do not pay rewards for free patterns.
- The image must be well lit and as clear as possible to give a really good view of the completed design. (If the picure is really not clear enough to use we will advise you to give you the chance
to send a better image through)
- The image submitted must be stitched exactly in full as per the pattern as it is a representation for everyone of how the design will look once completed, therefore unfortunately we cannot accept images in the rewards
program that use substituted colours other than DMC or that have major colour changes or adjustments from the original design. Also for designs which have several motifs we would need to see all the motifs in the
pattern stitched to claim a free pattern. You are still welcome to send these images through of adjusted patterns for the gallery if you like, however you will not be able to claim the free pattern. Please advise when you
send the image through of the adjustments made so we can make a note in the gallery for others.
- You agree that by posting the image we can display it in our completed gallery on our www.artecy.com website and also in our Artecy Shop on the page where the design
can be purchased. Full credit will be given to you as the stitcher and your image will not be displayed on social media or anywhere else without your permission.
- Free patterns selected will be sent through as PDF files only, we will not be able to print and post the free patterns out unfortunately. We do allow you to put the pdf file on a usb stick to
take to somewhere that you can print the pattern from if needed. Please do not email copies of the patterns to others as this is against our copyright. You can request a copy of the pattern with larger
symbols or a coloured version as well as per our normal pdf pattern adjustment service.
Feel free to either email your images through to email@example.com or post them in our facebook group here https://www.facebook.com/groups/artecy/
We will then check to see if the image meets our programs terms and conditions and we will advise you either way. If your image is accepted we will let you know how to claim your free pattern.
For all customers who have previously sent an image through for our gallery please email the name of the pattern and what page of the completed gallery your image is on to firstname.lastname@example.org and we will confirm your image with you and let you know how to claim your free pattern.
If we already have an acceptable image in our gallery for a design you are stitching you will not be entitled to the free pattern but please feel free to email your completed image for the gallery anyway, we would love to see it and display your work for all customers to see.
**We reserve the right to decline any gallery reward claim if we believe the stitched item has been stitched from a stolen pattern or if we believe the image is not your own, we may ask for proof of payment before paying the reward, and if no proof of payment supplied, we can decline your claim to the gallery reward***
Thanks and Best Wishes
Artecy Cross Stitch


Selena Gomez and Justin Bieber may be out to prove that “the couple that records together, stays together”…
The 20-year-old half-Mexican American singer/actress is reportedly working on new music with her boyfriend of more than a year.
Bieber is writing and producing tracks for Gomez’s next album, according to MTV, including one that he played for the Black Eyed Peas’ frontman, will.i.am. Speaking with Canada’s New Music Live, will.i.am recalled hearing the song.
“He was like, ‘Yeah, I wrote it for Selena. It’s great,” said will.i.am. “And it was really awesome. It was really, really dope.”
No word on what kind of song Bieber wrote, but earlier this year, Gomez told E! News that she wanted her next album to be “really fun.”
“It’s not going to be necessarily, ‘Here’s my tell-all,’” she said, referencing her famous boyfriend. “It’s going to be more of something that people could say, ‘It could be that or it could be this or it could be that.’ At the end of the day, I only make my music because I want it [to] be really fun, and if I could have people dance to it, relate to it, have a good time, that’s all I want.”
Gomez’s last album, When the Sun Goes Down, peaked at No. 3 on the Billboard 200 chart following its release in June 2011. The singer hasn’t officially announced a release date for her next effort, but it’s expected to come out sometime in 2013.
Gomez has also reportedly collaborated with Toby Gad and Rock Mafia on her new album.


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Although the unfolded protein response (UPR) as a consequence of endoplasmic reticulum (ER) stress emanat- ing from an intestinal epithelial cell (IEC) is well recognized to promote inflammation, little is known about the ways that an IEC-derived UPR regulates other non-canonical functions. Recently, we discovered that an IEC- associated UPR can regulate transmission of factors into the tissues or intestinal lumen that affect immune responses or the composition of the microbiota, respectively. The current research proposal addresses the un- answered question of how the UPR mediated regulation of factors involved in immune and microbiota function are important to inflammatory bowel disease (IBD), metabolic syndrome and susceptibility to enteropathogens. Our long-term goals are to parse out the specific mechanisms and consequences of UPR-mediated regulation of factors involved in immune and microbiota function important to these (patho)physiologic activities. The ob- jective of this research is to specifically define how an IEC-associated UPR can cause the sterile induction of Thelper17 (TH17) cells in tissues or regulate the luminal microbiome through affecting intelectin-1 (ITLN1) pro- duction, an elusive microbial lectin of poorly understood activity, that is increased in IBD and decreased in obe- sity. Our central hypothesis is that IEC-associated ER stress regulates the release of factors which affect a variety of physiologic functions important to immune development and regulation of the microbiome. The ra- tionale for our proposed research is that developing such insights into these mechanisms will shed important light on how they might lead to new perspectives on elucidating the role played by IEC-associated ER stress in regulating TH17 cell development through control of interleukin-6 and IEC-derived ITLN1 function as a risk factor for IBD and metabolic syndrome through the control of specific microbes. Our central hypothesis will be tested with three specific aims: 1) define the involvement of IEC ER stress in the sterile induction of TH17 cells; 2) identify how IEC-associated ER stress affects ITLN1 regulation of the microbiome, and; 3) characterize the con- sequences of ITLN1-deficiency on immunometabolic function.
In Aim 1 we will use a newly developed model of ER stress induction through selective expression of a glucose-regulated protein 78 (GRP78) inhibitor in the ER and other models to reveal how a UPR in the IEC instructs intestinal TH17 cell development independently of microbiota and the role played in microbial TH17 induction.
Aim 2 will define ITLN1 as a UPR-regulated, IEC- derived lectin which binds a limited range of pathobionts using a newly developed technique of ITLN1-Seq and how this regulates the induction of colitis.
Aim 3 will provide direct evidence that ITLN1 regulation of specific microbiota will act as a causal factor in obesity. Overall, this proposal is significant because it will allow us to understand how IEC-associated ER stress broadcasts itself into the tissues or lumen to regulate the host and/or the microbiota, respectively, and provide new dimensions on our understanding of several non-canonical activi- ties of an IEC-associated UPR.
The proposed research is relevant to public health because it will define how the unfolded protein response due to endoplasmic reticulum (ER) stress in intestinal epithelial cells (IEC) regulates factors involved in immune and microbiota function and consequently enhance our understanding of inflammatory bowel disease (IBD), meta- bolic syndrome and susceptibility to enteropathogens. These studies will specifically reveal how IEC-associated ER stress broadcasts itself into the tissues or lumen to regulate critical host and/or microbiota functions, respec- tively. The proposed studies are relevant to the mission of the NIDDK because they are expected to identify new insights into factors associated with risk for IBD, metabolic syndrome and enteropathogens together with exper- imental models and tools that will be useful in elucidating potential mechanisms and thus therapeutic strategies for inhibiting inflammation and obesity.
|Hosomi, Shuhei; Grootjans, Joep; Huang, Yu-Hwa et al. (2018) New Insights Into the Regulation of Natural-Killer Group 2 Member D (NKG2D) and NKG2D-Ligands: Endoplasmic Reticulum Stress and CEA-Related Cell Adhesion Molecule 1. Front Immunol 9:1324|
|Iyer, Shankar S; Gensollen, Thomas; Gandhi, Amit et al. (2018) Dietary and Microbial Oxazoles Induce Intestinal Inflammation by Modulating Aryl Hydrocarbon Receptor Responses. Cell 173:1123-1134.e11|
|Aden, Konrad; Tran, Florian; Ito, Go et al. (2018) ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS-STING. J Exp Med 215:2868-2886|
|Zhao, Ming; Xiong, Xiwen; Ren, Kaiqun et al. (2018) Deficiency in intestinal epithelial O-GlcNAcylation predisposes to gut inflammation. EMBO Mol Med 10:|
|Kim, Walter M; Kaser, Arthur; Blumberg, Richard S (2017) A role for oncostatin M in inflammatory bowel disease. Nat Med 23:535-536|
|Pyzik, Michal; Rath, Timo; Kuo, Timothy T et al. (2017) Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury. Proc Natl Acad Sci U S A 114:E2862-E2871|
|Tschurtschenthaler, Markus; Adolph, Timon E; Ashcroft, Jonathan W et al. (2017) Defective ATG16L1-mediated removal of IRE1? drives Crohn's disease-like ileitis. J Exp Med 214:401-422|
|Kaser, Arthur; Blumberg, Richard S (2017) The road to Crohn's disease. Science 357:976-977|
|Zeissig, Sebastian; Peuker, Kenneth; Iyer, Shankar et al. (2017) CD1d-Restricted pathways in hepatocytes control local natural killer T cell homeostasis and hepatic inflammation. Proc Natl Acad Sci U S A 114:10449-10454|
|Hosomi, Shuhei; Grootjans, Joep; Tschurtschenthaler, Markus et al. (2017) Intestinal epithelial cell endoplasmic reticulum stress promotes MULT1 up-regulation and NKG2D-mediated inflammation. J Exp Med 214:2985-2997|
Showing the most recent 10 out of 79 publications

domain: biology


text:
The Sgt. Windflower Mysteries are a light mystery series set in Newfoundland on the east coast of Canada. These cozy-like books follow the adventures of Sgt. Winston Windflower, a Cree from Northern Alberta as he finds a new life and new loves in the tiny village of Grand Bank. There are crimes and mysteries for the Canadian Mountie to investigate and solve but the Sgt. Windflower Mysteries are more about family, friends, good food and good times.
The recurring cast of characters include the love of his life, Sheila Hillier who keeps him well-fed and grounded in reality. There’s also his fellow Mounties like Corporal Eddie Tizzard and a long list of bad actors, both local and just visiting, to cause havoc in their sleepy little town. Windflower brings his native background and traditions with him and finds ways to use them to help himself and his friends through difficult times. Rounding out his life are his collie, Lady, who often has adventures of her own and some new additions to his family that appear in the latest book, Darkest Before the Dawn.
The Walker on the Cape (Book 1)
A man’s body is found on the Cape in a small fishing community on the East Coast. At first everyone thinks it’s a heart attack or stroke. But then it is discovered that he was poisoned. Who would do this and why? Finding that out falls to Sergeant Winston Windflower of the RCMP along with his trusted side-kick Eddie Tizzard. Along the way they discover that there are many more secrets hidden in this small community and powerful people who want to keep it that way.
Windflower also discovers two more things; a love of living in a small community that is completely different from his up-bringing in a remote Indian reserve and maybe the love of his life. He gets a taste of East Coast food and hospitality as well as a sense of how crime and corruption can linger beneath the surface or hide in the thick blanket of fog that sometimes creeps in from the nearby Atlantic Ocean.
Meet the Author
Mike Martin was born in Newfoundland on the East Coast of Canada and now lives and works in Ottawa, Ontario. He is a long-time freelance writer and his articles and essays have appeared in newspapers, magazines and online across Canada as well as in the United States and New Zealand. He is the author of Change the Things You Can: Dealing with Difficult People and has written a number of short stories that have published in various publications including Canadian Stories and Downhomemagazine.
The Walker on the Cape was his first full fiction book and the premiere of the Sgt. Windflower Mystery Series. Other books in the series include The Body on the T, Beneath the Surface, A Twist of Fortune and A Long Ways from Home, which was shortlisted for the Bony Blithe Light Mystery Award as the best light mystery of the year. A Tangled Web was released in 2017 and the newest book in the series is Darkest Before the Dawn.
The Walker on the Cape was a really good read and a great start to the series. I liked how the mystery began with the characters thinking the murder was actually heat stroke before it was discovered that it was poison as it kept the book a mystery even from the start!

domain: literature