DiffMix brings citizens and art together
Diffmix is a project within the framework of the European Capital of Culture Esch2022. Diffmix is even more than that. It’s a digital meeting place between residents of Differdange and artists from Europe.
DiffMix invites all citizens to mark places in the municipality where they would like to see changes. From the places entered, five will be selected. Again, in an open and transparent selection process. For each of the five places, there is an open call on diffmix.lu, where artists from Europe can submit ideas.
The ideas will be open to be commented by citizens and discussed with the artists. The ideas that the residents decide on will be implemented. It’s a creative process that allows participation as well.
The results of the process can be experienced by visitors to the Capital of Culture and perhaps even to be shaped by them. There is only one thing DiffMix cannot do: build parking lots. Even though this is certainly one of the citizens’ concerns DiffMix is most often confronted with. 🙂
DiffMix creates an interactive channel between the City of Differdange, its inhabitants and the European artists in order to determine neighborhood locations that have direct influence on the local community life. The top down approach to cultural interventions and design of public space often makes them selective and sometimes exclusive, and, as the result, they are not appropriated by the citizens. DiffMix invites citizens to re-appropriate public space of the city of Differdange in order to create community places and promote cultural mix.
The transformation of public space into community places can only happen if local inhabitants are included. DiffMix invites artists (designers, architects and other creatives) from all over Europe to realise installations and side-events that will support this co-creation process. Citizens participate in the reflection, creation and realization process and take advantage of it in the long run.
The co-creation process as a methodology for participation gives citizens the possibility:
- to express their needs and ideas for the space they live in and interact with,
- to decide on the interventions, and
- to participate in the implementation process.
Through participation, DiffMix assures that residents have a voice in shaping the public and cultural spaces.
Participation is hereby understood as an open process, including: submitting opinions, being an active part of the design process and putting in work or just using the space that had been redefined. Citizens can engage at different points of the project matching their needs.
Definition of places & citiziens’ needs and ideas for the Creative Brief
Step 1. Discover places for co-creation
As the first step of the DiffMix project, citizens point out places and their aspirations for a possible co-creation (‘artistic intervention’) in various neighborhoods of Differdange on DiffMix interactive map. Additional information from local associations, citizen dialogues and creative workshops helps to identify areas where changes are important for creating a better neighbourhood feeling. A process in which the City of Differdange is involved along with the community. As a result, at least four specific public spaces as well as the needs and aspirations of the participating citizens are identified. The outcoming Creative Briefs are the basis for the next step.


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POOR work habits like not taking a break, staying late or eating lunch ‘al-desko’ are damaging the health of employees in South West England, physiotherapists are warning.
Almost one in five people (15 per cent) surveyed for the Chartered Society of Physiotherapy (CSP) revealed they worked through their lunch every day.
Of those who do manage to take a break, 47 per cent said they ate at their desk.
Only 23 per cent leave their workplace to go outside for a break, and only one per cent goes to the gym, meaning most miss out on any kind of physical activity during the day. And 31 per cent of workers said their employer provided any kind of exercise opportunities, such as a subsidised gym membership, a lunchtime running club, or an after work fitness class.
The survey also found 46 per cent of people had to cancel exercise plans because of work, a third (33 per cent) said they started earlier or finished later than their contracted hours every day.
The CSP is calling on employers to find ways to support staff to be more physically active during the working day in order to reduce their risk of developing musculoskeletal problems like back and neck pain and more serious illnesses such as cancer, heart disease and stroke.
Prof Karen Middleton, chief executive of the CSP, said: “Full-time workers spend a significant bulk of their week at work, or travelling to and from it. Finding ways to build in time to do at least 30 minutes of moderate intensity physical activity, five times a week, can be a challenge.”

domain: news


I understand the difference between trimmed surface and untrimmed surface, and some commands must consider surface property, such as Match surface. I also read the Rhino level 2 tutorial and our forums.
In 2D plan, circle with Planar Surface command - the circle is trimmed surface. Similarity, square with Planar Surface command - the square is untrimmed surface.
My question is that why trimmed surface and untrimmed surface ( two concepts) are introduced in Rhino. Why one trimmed surface is not a new untrimmed surface. The goal or reason we must distinguish trimmed surface and untrimmed surface when Mcneel writes the program ?
Most of the time PlanarSrf will give you a trimmed surface, except I guess for the special case of a rectangle that it recognizes and makes untrimmed.
The ability to trim surfaces is the ‘killer’ feature of NURBS, the reason ALL CAD software uses them. In mesh-based workflows trying to just drill a hole in something is an ordeal that can’t produce an actual circle and changes the structure of the surrounding area.
Yes. All NURBS surfaces are essentially like a rectangular rubber sheet with 4 sides. The sheet can be stretched and twisted in any way but the basic ‘rectangular’ structure remains - the “U” and “V” directions that Martin mentions above. There is one possibility to collapse one or two of the edges to zero length to create ‘poles’ - this is how one can get a sphere or a cone, or even the flat circle above (which is actually just a ‘flat’ cone). But aside from the collapsed outer edges, the rectangular UV structure always remains.
There are however an infinite number of surface configurations that cannot be represented with just the ‘natural’ untrimmed edges. A simple example would be a planar surface that has more than 4 edges. This type of surface cannot be defined as a single untrimmed surface defined by its natural edges. It can only be described by a trimmed surface - one where the natural edges have been cut away by the outer border, or, it must be broken up into several joined untrimmed surfaces that have four natural edges or less.
It is for this reason that it is very important to understand the difference between untrimmed and trimmed surfaces and their respective properties and roles in Rhino.


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June payroll report tops expectations
- July 6, 2021
Balance Sheet Risk Management
Financial Institutions | Kennett Square, PA
Prior week summary
The major U.S. equity indices continued their march higher last week with the S&P 500 and Nasdaq Composite Indices ending the week at all-time highs as generally favorable economic data outweighed concerns of a new surge of COVID-19 delta variant cases in the U.S. After rising five basis points the Friday prior on the back of higher-than-expected inflation readings, the 10-year Treasury yield relinquished those gains last week falling roughly 10 basis points over the week to 1.44%. In turn, inflation expectations turned lower, albeit smaller in magnitude, with the 10-year breakeven inflation rate falling to 2.34% to finish the week. Market participants were the beneficiaries of several key economic data releases last week that largely pointed to a strengthening U.S. economy. The Conference Board Consumer Confidence Index increased to 127.3 in June, marking a pandemic-era high and smashing the consensus estimate calling for a modest decline from May’s 120.0 reading. Notably, the share of participants characterizing jobs as “plentiful” increased to 54.4% from 48.5% in May, while households viewing jobs as “hard to get” fell to 10.9% from 11.6% the month prior. Thursday’s release of the ISM Manufacturing Index pointed to continued strength in the manufacturing industry. The June reading fell slightly below both the May reading and the consensus estimate but remained well within expansionary territory. Supply chain bottlenecks have plagued the industry and the latest release highlighted a continuation of those supply chain woes with order backlogs remaining elevated. Additionally, the “prices paid” component of the report pushed higher to 92.1, the highest reading since 1979. While market participants were gearing up for the long weekend, all eyes turned to the June non-farm payroll report on Friday. According to the Labor Department release, the U.S. economy added 850,000 jobs in June, crushing expectations for a 720,000 increase and notching the biggest monthly gain since August 2020. Unexpectedly, the unemployment rate defied calls for a decline and increased to 5.9% from 5.8%. Lastly, jobless claims moved lower last week to 364,000 claims, a pandemic-era low.
After the White House and a bipartisan group of Senators agreed in principle to a $1.2 trillion infrastructure bill the week prior, negotiations continued last week in the lead-up to the holiday. On Thursday, the House of Representatives passed a $715 billion infrastructure proposal, titled the INVEST in America Act, setting a key line in the sand for negotiations with the Senate on the bipartisan proposal. The INVEST in America Act allocates $343 billion to roads, bridges, and safety, and $109 billion for mass transit. Political wrangling is set to continue in the coming weeks on Capitol Hill with House Speaker Nancy Pelosi indicating a September 30 deadline for the completion of negotiations. While the bipartisan deal brought renewed optimism to infrastructure negotiations, the bill’s prospects remain very unclear as Pelosi indicated that a Democrat-passed reconciliation bill must accompany the infrastructure bill before the House would vote on it saying, “Let me be really clear on this: we will not take up a bill in the House until the Senate passes the bipartisan bill and a reconciliation bill. If there is no bipartisan bill, then we'll just go when the Senate passes a reconciliation bill”, but noted, “I'm hopeful that we would have a bipartisan bill. I think it would be really important to demonstrate the bipartisanship that has always been a hallmark of our infrastructure legislation.”
As the regulator-mandated end to new LIBOR contracts looms near, several alternative reference rates have surfaced in recent months with no clear winner emerging. While the Alternative Reference Rates Committee-endorsed SOFR rate has been in the pole position for years, credit-sensitive alternatives have also jockeyed for position in the post-LIBOR landscape recently. Last week, market participants heard from some of the biggest players in the transition space. In a LIBOR transition panel hosted by Bloomberg on Tuesday, Thomas Pluta, global head of linear rates trading at JP Morgan, predicted a multi-rate environment post-LIBOR arguing that, “It’s appropriate to have a compounded-in-arrears SOFR for the majority of the market, and then the credit-sensitive rates will also have their proponents. I think we’ll be in a multi-rate world with SOFR in multiple forms and some credit-sensitive rates existing alongside SOFR.”
The look forward
In a holiday-shortened week, market participants are gearing up for updated figures on the ISM Services Index, wholesale inventories, and jobless claims, among others. The Minutes of the FOMC’s June meeting are released on Wednesday.
Market implied policy path (Overnight indexed swap rates)
Chatham Hedging Advisors, LLC (CHA) is a subsidiary of Chatham Financial Corp. and provides hedge advisory, accounting and execution services related to swap transactions in the United States. CHA is registered with the Commodity Futures Trading Commission (CFTC) as a commodity trading advisor and is a member of the National Futures Association (NFA); however, neither the CFTC nor the NFA have passed upon the merits of participating in any advisory services offered by CHA. For further information, please visit chathamfinancial.com/legal-notices.
Transactions in over-the-counter derivatives (or “swaps”) have significant risks, including, but not limited to, substantial risk of loss. You should consult your own business, legal, tax and accounting advisers with respect to proposed swap transaction and you should refrain from entering into any swap transaction unless you have fully understood the terms and risks of the transaction, including the extent of your potential risk of loss. This material has been prepared by a sales or trading employee or agent of Chatham Hedging Advisors and could be deemed a solicitation for entering into a derivatives transaction. This material is not a research report prepared by Chatham Hedging Advisors. If you are not an experienced user of the derivatives markets, capable of making independent trading decisions, then you should not rely solely on this communication in making trading decisions. All rights reserved.21-0183
Our featured insights
Equities shake off virus jitters; ARRC talks Term SOFR
Despite a sharp selloff to start the week, the three major U.S. equity indices recovered to finish the week higher, each setting new all-time highs, as market participants focused on a strong start to the corporate earnings season and shrugged off mostly weaker-than-expected economic data and renewed fears of the COVID-19 delta variant.
Inflation readings top expectations
The major U.S. equity indices moved lower for the week, snapping a three-week winning streak, as investors turned their attention to a slew of economic data updates and Federal Reserve Chair Powell’s semi-annual testimonies before Congress.
Regulators voice support for SOFR
Despite the recent rise in COVID-19 cases linked to the delta variant and weaker-than-expected economic data, the major U.S. equity indices extended their run last week, setting new all-time highs, while long-term Treasury yields continued their drift lower, falling to multi-month lows.
Increase lending capacity
Many financial institutions have excess liquidity due to the global pandemic and resulting economic stimulus. Management can deploy this liquidity into new loan originations or the investment portfolio. Although bond returns are better than cash, a more attractive return may be provided from mortgage loans.
Going up? Elevating loan yields with swaps
Rather than simply accepting their fate and holding onto low-yielding floating-rate assets, financial institutions can use swaps to improve their net interest margin.
Managing excess liquidity
Excess liquidity is a challenge currently facing many financial institutions. Some are deploying this liquidity by extending duration via the bond and loan portfolio. In the process, they are introducing additional rate risk, but accepting this risk isn’t necessary.
Could a resurgence of inflation be around the corner?
After years of stubbornly low inflation, markets and economists expect prices to remain stable for the foreseeable future. But there are warning signals from various parts of the global economy that suggest a resurgence of inflation is more likely than many anticipate.
Credit unions: extending asset duration and managing rate risk
Credit unions have experienced a significant increase in member deposits during the pandemic which has led to excess liquidity and low-yielding cash balances. Hedging tools may help these institutions extend asset duration and improve margins while also managing their incremental rate risk.


Offical Community Plan in Draft Review Stage
July 18, 2011
FORT NELSON - A draft Official Community Plan (OCP) has been prepared for the Northern Rockies Regional Municipality. The Northern Rockies Regional Council is now seeking the public's feedback on this draft document and its associated land-use maps to finalize the OCP project.
The Municipality is hosting a Public Meeting & Open House to present an overview of the Draft OCP, answer any questions you may have, and hear your comments/suggestions.
The Public Meeting & Open House will be held on the evening of Thursday, August 4, from 6:30 - 9:00 p.m. at the Municipal Hall, with the presentation beginning at 7:00 p.m.
Regional Council would like to thank all of the residents whose time and input have helped shape the OCP draft, and encourage everyone to come out and have their voices heard at the August 4th Public meeting.
The Draft OCP is available on the Municipal website, where you'll also find a comment card for you to provide your thoughts. Hard copies of the document are also available at Municipal Hall.
For more information or to review the document, please contact the NRRM Community Development & Planning Department at 250-774-2541 or visit the Northern Rockies Regional Municipality website at http://www.northernrockies.ca/EN/main/business/planning-development/NRRM-OCP.html.Go to Top


Wood County students to be asked about sex, drugs
WISCONSIN RAPIDS — Middle and high school students across Wood County will answer nearly 90 questions about drug and alcohol use, sexual activity and other risky behaviors this week, ultimately providing school districts with better data about their students' potentially harmful behavior.
The questions, which will be administered to students in grades eight, 10 and 12, are part of the Wisconsin Youth Risk Behavior Survey, a voluntary and anonymous questionnaire that aims to identify trends in youth behavior.
The survey — organized by the Marshfield Clinic Center for Community Outreach, Marshfield Area Coalition for Youth, the Wood County Health Department, Healthy People Wood County and Healthy People Wood County Healthy Growth and Development Team — is a federal questionnaire, developed from the Centers for Disease Control and Prevention. It asks students about their behaviors that play a part in unintentional injuries and violence; sexual behaviors that contribute to unintended pregnancy and sexually transmitted diseases; inadequate physical activity; unhealthy dietary behaviors; and tobacco, alcohol and drug use.
It has been distributed to schools in the area since 2006. But for the first time since its inception, the survey will be administered to all Wood County public schools.
With the exception of the Marshfield School District, use of the survey has been inconsistent among schools in Wood County, said Danielle Luther, manager of substance abuse prevention at the Marshfield Clinic Center for Community Outreach. And in 2014, the test was not administered because of a funding flaw, Luther said.
But this year's participation will now give the county enough comprehensive data to establish a baseline to measure the health habits of these young adults at the county level, said Kristie Rauter, community health planner at the Wood County Health Department.
In the past, Luther said such surveys have helped in identify youth trends, such as the decrease in underage drinking and the increase in prescription drug use among young adults. Using this these trends and data, Rauter said community health organizations and school districts now will be able to plan health initiatives around specific risky student behavior.
In addition to providing the health department and other community organizations with a better understanding of youth health, the survey also will give school districts "granular-level data" specific to its students so it can address any positive or negative behavior trends in its population, Rauter said.
After all, just because Wood County schools are close to each other, it doesn't mean students all have the same habits, Rauter said.
"Schools are not one-size fits all," Rauter said. "Essentially, the youth in those schools have different behaviors."
The questionnaires, which are completed via pen and paper, will cost about $13,000 to administer at all schools this year, Luther said.
Moving forward, Luther said the many organizations involved plan to administer the test to youths every other year. In 2017, they plan to widen the breadth of participants to all students in grades eight through 12. Rauter said the data analysis of these surveys will be completed in spring 2015.
Melanie Lawder can be reached at email@example.com or 715-423-7200. Find her on Twitter as @mel_lawder.


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Today marks the Deuxieme Anniversaire for me. A Sunday two years ago that I thought I could share. But it is way too personal and I am still too close. This series is about reconnecting with my work. Seeking an ease with a medium that I use to use only as an alternative. Finding a way in the studio while I am away from my home. Trying to find that joy and spontaneity that I used to find walking the wetlands, exploring barrier islands. I love exploring. I love Santa Fe. And all of the areas I have visited these past two years have something of interest to note. But today there is a tug, a tug on my heart that will always be there. Wanting to be there, with you, in that sliver by the river. Wanting to walk my bricks beneath the oaks down to the corner for café au lait and a visit with a friend. Chatting at the bookstore, catching up on the news, grabbing Ace's new book, or Doug's or Randy's or Tim's, or John Ed's. But instead, I will have cake here. In a Texas town. And make it alive as if I were walking my island again.
Tuesday, August 28, 2007
Posted by Janice C. Cartier at 5:41 AM

domain: hobby


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POST DATE 9/15/2016
END DATE 10/15/2016
The maintenance mechanic is responsible for the
efficient and economical operation and maintenance of
the waste water treatment plant and its equipment in
conjunction with participating in the maintenance of the
plant and equipment resulting in top production
efficiency and reduction of down time.
Strong understanding of the production equipment
associated with manufacturing operations including UHT,
HTST and Aseptic processors, fillers, case erectors and
other packaging line equipment.
Knowledge of electrical schematics and abilities to
troubleshoot basic control circuit wiring. This
includes motor control circuits, variable frequency
drives, motor diagnosing and main / secondary branch
Ability to effectively use a VOM meter, amp probe,
megger, rtd and 4- 20 ma simulators.
Ability to interpret ladder logic and have basic plc
knowledge associated with microprocessor- controlled
equipment. This includes verifying proper operation
of input / output modules and components connected
to these devices.
Ability to navigate and comprehend HIM screens
associated with all filler machines and processing
Knowledge and comprehension in the Purity,
Tetra-Pak, Osgood, Liqui-box filler operations, and
any future filler line, including:
Sequence of operation, cip and sterilization
Knowledge of pneumatic logic and sequence of
operation of the Liqui-box filler.
Troubleshooting using the Chessell and Hengsler
Troubleshooting and correcting production issues
Cup seal failures
Peroxide flows and high residuals
Capper unit (Tetra-Pak)
Gable top and bottom seal failures
Ultrasonic welder (Tetra-Pak)
Must demonstrate knowledge of all production
coding equipment, including:
Nozzle drive alignment procedures
Satellite break-off knowledge and comprehension
Menu screen navigation
System flushes and ink renewal procedures
Comprehensive knowledge and use of technical
Knowledge of the boiler, plant air and ammonia
refrigeration systems in order to maintain daily
operations. Demonstrate knowledge of the ice
builders, condensers, refrigeration compressors,
pumps and valves. Must be able to determine normal
operating conditions within the systems and proper
start-up and shut down procedures.
Must maintain a Hazmat certification.
Must be flexible in weekend / shift rotation
Must possess skills in routine welding and
Must be able to complete assigned pms, work orders
and other duties as assigned within a timely manner
with limited supervision.
Must be proficient in requisitioning / maintaining
parts inventories to ensure an uninterrupted flow of
parts through the department.
Knowledge of Waste Water Treatment Plants.
Oversee and operate the WWTP within set limits as
defined in the Industrial Wastewater Permit.
Maintain accurate records, logs, files and reports
on a timely basis
Ensure daily inspections are conducted of the plant
and plant equipment
Maintain equipment and utilize the Preventative
Oversee the sludge operation and third party hauler
Maintain and update as needed, operational and
troubleshooting guidelines; and Standard Operation
Procedures for the WWTP operation
Maintain a clean and safe work environment
Keep supervisor informed of any changes in operating
procedures, any unusual circumstances and any
actions planned to resolve problems
Be prepared to discuss plant operations with
visitors to the plant in a professional manner
Maintenance and cleaning of effluent, sampling
Maintenance and cleaning of influent and effluent
Maintenance and cleaning of all pipes and pumps
Maintenance and cleaning of Wastewater Treatment Lab
Completion of preventative maintenance work orders
Wastewater testing as needed (in-house)
Daily sampling per city industrial permit
Recording of daily readings and plant activities as
OTHER SKILLS AND ABILITIES:
Basic Computer Skills.
Knowledge of Good Manufacturing Practices.
Knowledge of safety programs and procedures.
Knowledge of Hazmat and Waste Water Treatment Plant
To perform this job successfully, an individual must be
able to perform each essential duty satisfactorily. The
requirements listed below are representative of the
knowledge, skill and/or ability required. Reasonable
accommodations may be made to enable individuals with
disabilities to perform the essential functions.
EDUCATION and/or Experience:
High School Diploma or equivalent; and three to five
years related experience, and/or equivalent
combination of education and experience; prefer
completion of trade school or apprenticeship
Ability to read and write, and interpret documents
such as safety rules, operating and maintenance
instructions, and procedure manuals.
Ability to read, comprehend and follow instructions.
Ability to effectively present information in
one-on-one and small group situations to customers,
clients and other employees of the organization.
Ability to hear and perceive information at normal
spoken word levels.
Must be able to perform basic math skills.
Ability to demonstrate superb decision-making
ability to determine best course of action in
troubleshooting and repairing equipment in a timely
and efficient manner.
The physical demands described here are
representative of those that must be met by an
employee to successfully perform the essential
functions of this job. Reasonable accommodations may
be made to enable individuals with disabilities to
perform the essential functions.
Work requires climbing, balancing, stooping,
kneeling, crouching, crawling, reaching, standing,
walking, pushing, pulling, lifting, grasping, and
The employee must frequently lift and/or move up to
Specific vision abilities required by this job
Distinguish colors accurately.
The work environment characteristics described here
are representative of those an employee encounters
while performing the essential functions of this
job. Reasonable accommodations may be made to enable
individuals with disabilities to perform the
The worker is subject to inside and outside
environmental conditions, extreme cold, noise,
vibration, hazards, atmospheric conditions, oils,
and wearing a respirator.
The noise level in the work environment is usually
Saputo Dairy Foods USA, LLC is an Affirmative


text:
The Tenant of Wildfell Hall begins with the arrival of the beautiful and mysterious Mrs Graham in a quiet country neighbourhood. Everyone is thrilled to have someone new to talk about, but infuriated by the secrecy that surrounds her. Nasty rumours circulate.
All this takes place against a backdrop of country houses, vicars and picnics. So far, so Jane Austen - and at times this does feel a bit like a rough, early Austen. But the Tenant of Wildfell Hall is made of messier, bloodier and more overtly political stuff, and we are denied the guaranteed comfort of a happy ending. The title of "the first feminist novel" has been awarded to other books, perhaps with less justice.
Mrs Graham's real name is Helen Huntingdon, and she and her son are fugitives. Her husband Arthur is a drunkard and an adulterer, but she has disgraced herself by leaving him.
From the contents of Helen's diary, we learn that she was warned off marrying Huntingdon, but he was very charming, and she was very young. She tried to make it work for years, but gave up when she learned he was having sex with a house guest. The scene where she confronts him tells us everything we need to know about the legal enslavement of women in 19th-century England:
She: "Will you let me take our child and what remains of my fortune, and go?"
She: "Will you let me have the child then, without the money?"
He: "No, nor yourself without the child. Do you think I'm going to be made the talk of the country for your fastidious caprices?"
Forced to stay, Helen bans her husband from her bed. (The slamming of Helen Huntingdon's bedroom door against her husband, May Sinclair later wrote, reverberated throughout Victorian England.) Eventually she does flee - to Wildfell Hall.
This is not a perfect novel. Helen is a goody-goody bore at times, but she is manifestly too interesting for Gilbert Markham, the farmer we are asked to believe her in love with. But if you can forgive that, and more importantly, weather the road-block of a first chapter, this is a cracking page-turner.
Brontë died less than a year after The Tenant was published. Her last words, whispered to her sister Charlotte, were: "Take courage."

domain: literature


text:
Sportsmail revealed City would listen to offers for the Ivorian as they look to overhaul an ageing squad at the end of a faltering campaign.
Toure is determined not to be forced out but the Chilean, speaking ahead of Sunday’s visit of West Ham, acknowledged the midfielder had underperformed and dismissed claims he should be given a rest.
‘I don’t think he’s happy with his performance this year - and nor am I,’ said Pellegrini. ‘He doesn’t need a break.’
Toure, who has two years left on a £220 000-a-week deal, has come in for criticism amid the collapse of City’s Premier League defence. But Pellegrini, who faces questions over his own future, said the 31-year-old would be backed. ‘He’s a very important player and he will have my support until the end of the season,’ he said. City, who have taken just 18 points from the last available 39, take on Sam Allardyce’s side knowing that defeat will leave fifth-placed Liverpool with the chance to close the gap to one point with victory at West Brom next weekend. City will also face the Hammers without captain Vincent Kompany, who could miss the rest of the campaign with a muscle injury.
With his manager in the firing line, City goalkeeper Joe Hart insisted the players should take responsibility. ‘People have been disappointed in their own performances,’ said the England No 1. ‘We’ve let the manager down a few times and we’ve baffled ourselves because we feel like we’ve got the quality to beat anyone and that’s not been the case.’
Hart added that Pellegrini retained the backing of the dressing room. ‘He’s been great,’ Hart said. ‘He’s hard, he kind of says it how it is and you can’t ask for much more than that from a manager.’
Pellegrini, however, said: ‘The players have responsibility but I choose the players.’
Original source: Pellegrini not happy with Yaya


text:
July 13, 2012
On July 5, the Department of Homeland Security announced on the FedBizOpps.gov websitethat it plans to buy thirty-six Colt LE901 rifle systems. The latest DHS purchase follows a solicitation issued on July 13 for the purchase of .223 Caliber Remington Enhanced Performance Ammunition in excess of $500,000. The Colt assault weapons are designed to accept the .223 ammunition.
“The 901 is much more than your typical assault rifle,” notes the Prepper Podcast Radio Network website. The weapon will allow “the DHS/FEMA foot soldier to go from an assault rifle to picking off ‘terrorists’ at a distance by only changing the upper receiver.”
In June, FedBizOpps.gov listed a “Personal Defense Weapons Solicitation” issued by DHS calling for 5.56x45mm NATO select-fire firearms “suitable for personal defense.” The due date for the solicitation is mid-October of 2012
In April, we reported on the DHS awarding contracts to a munitions company for 450 million rounds of .40 caliber hollow point ammunition. Prior to this, the feds awarded Winchester a five year contract for 200 million rounds .40 caliber ammunition.
“I could understand if the U.S. military was ordering ammunition in this quantity. When you fight wars you can go through ammunition very rapidly,” the American Dream blogcommented following the extraordinary purchase. “But the Department of Homeland Security is only supposed to be shooting at people very rarely.”
Also in April, Paul Joseph Watson reported on the DHS purchasing bullet resistant guard booths. “The purpose behind the bullet proof booths is unknown, but the DHS has publicly announced that it plans to increase the number of unannounced checkpoints manned by TSA VIPR teams and other federal agents beyond the 9300 that were set up last year alone,” Watson wrote at the time.
In February, trends forecaster Gerald Celente told Alex Jones 2012 will witness bank runs, riots and other social dislocation as the economy collapses later this year. Celente has issued spot-on economic forecasts since 1980.
- DHS agencies to buy up to 7,000 new 5.56x45mm NATO “personal defense weapons” (EndtheLie.com)
- DHS agencies to buy up to 7,000 new 5.56x45mm NATO ‘personal defense weapons’ (theaveragejoenewsblogg.com)
- DHS agencies to buy up to 7,000 new 5.56x45mm NATO ‘personal defense weapons’ (activistpost.com)
- DHS agencies to buy up to 7,000 new 5.56x45mm NATO “personal defense weapons” (raptureimminent.wordpress.com)
- DHS agencies to buy up to 7,000 new 5.56x45mm NATO “personal defense weapons” (pakalertpress.com)
- Is It Time to Write a Eulogy for the US Constitution, Civil Liberty, and National Sovereignty? (servehiminthewaiting.wordpress.com)
- DHS agencies to buy up to 7,000 new 5.56x45mm NATO “personal defense weapons” (zionistoutrage.com)
- Brian Terry Was Shooting Beanbags Against Cartel Assault Rifles (righttruth.typepad.com)
- Rumor that Obama administration is preparing for civil war (fellowshipofminds.wordpress.com)
- CORE15 Great AMERICAN AR-15 Giveaway (ar15news.com)


text:
The following equipment and facilities are listed under this category.
Stainless-steel analytical batch mill for 2 different grinding procedures
The Ankom 220 Fiber Analyzer is used for the determination of crude fiber, ADF (acid detergent fiber) and NDF (neutral detergent fiber)in all feeds and forages.
System designed for metabolic screening and monitoring of IEM and clinical research into the amino acid composition of physiological fluids. Suitable for both human and animal use, the Biochrom 30+ System can identify and quantify up to up to 56 amin
The CS-530 is designed for the rapid simultaneous determination of carbon and sulphur in coal, coke, oil. ashes, catalysts, lime, gypsum, soils, rubber, leaves, soot, tobacco, waste, sand, glass etc.

domain: chemistry


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Does anyone have a classic equine esp pad they'd like to sell? I'd like one like this here Saddle and Tack Warehouse – Classic Equine Esp Felt Top Pad (Western Saddles And Tack, Saddle Pads) in decent shape. Thought I'd just check here before I went and bought a new one
I am also looking for a flank cinch, a thicker roper style one, medium oil. Thanks!


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What happens to the body when we fast?
Fasting is associated with many health benefits, this article will break down what happens to the body when we fast and why a lot of these changes are good for us.
The human body is actually really good at adapting to short and even long periods of time with very little or no food. If we take a look back through the history of human existence, we will see that we are actually living in a very short period of abundance with easy access to food.
During the earlier stages of human development, fasting was much more common. It was a consequence of seasonal changes, climate changes, droughts, inability to preserve food successfully, and many other factors.
Our body’s ability to store fat as a reserve for tough times is a consequence of our evolution. That is why, during fasting time, the body is able to reach for the stored fat and use it as an energy source.
What do we use for energy when we do not fast? The answer is glucose. Glucose is our primary energy source. The body prefers glucose because it is easily accessible and simple to metabolize. We get glucose from carbohydrates, normally the most abundant constituent of most foods. The problem appears when we consume too many carbs. When that happens, the body stores the excess glucose as glycogen in the liver and, ultimately, as fat.
Most of the time we are utilizing glucose (sugar) from our diets and glucose stores in the body for energy. It is not until sugar is both removed from the diet and the stored sugar is fully burned off that the body reaches for fat for energy.
Step by Step Effect of Fasting
Step 1. The Beginning
Physiologically, the fasting period starts when all the food from the previous meal is digested and absorbed. We wake up every morning in the fasting state.
Step 2. Spending the Glycogen
After all the glucose from the last meal we ate has been used up, the body will reach for the glucose reserve that has been stored in the sugar cells. In other words, before the body reaches for fat, it will exhaust the stored glucose also. This usually takes 6 to 24 hours after all the glucose is gone.
Step 3. Gluconeogenesis
Once the body is out of glycogen (stored glucose), the liver starts to produce new glucose. This process is known as gluconeogenesis. New glucose is made from amino acids. This requires the use of excess protein, which is sourced out from various tissues including the muscles. However, the process does not last long enough to cause a significant loss of muscle mass.
Step 4. Ketosis
Approximately, after two or three days the use of fat for energy begins. At this point the levels of insulin, a hormone necessary for the metabolism of glucose, are very low. These low insulin levels trigger lipolysis, the process of breaking down lipids (fat) for energy.
Fatty acids, the products of lipolysis, are a good source of energy for all tissues except the brain. In order to fuel brain activity, fatty acids are broken down further into ketone bodies in a process called ketosis. These ketone bodies are successfully delivered by the blood to the brain tissue, maintaining its normal function.
From this point on, fasting makes a full effect and normal functioning of the body is maintained until all fat reserves are spent.
Fasting and Hormone Levels
Fasting also influences the levels of certain hormones in our body. However, our knowledge about the effects of fasting shows that these hormonal changes are mostly positive and health beneficial.
As it was explained before, insulin has an important role in glucose metabolism. Our body needs higher levels of insulin in order to use glucose as an energy source. Since most foods contain carbs (a source of glucose) insulin spikes are common after every meal in healthy, non-diabetic, individuals.
Fasting, on the other hand, maintains insulin at a low but healthy level. Some studies even show that fasting increases insulin sensitivity. Low insulin levels also help the body to excrete the excess water and salt. This is the reason why all low-carb diets result in a great average weight loss during the first week.
Somatotropin (Human Growth Hormone)
One of the main causes of age-related loss of muscle mass and bone density is the decreased secretion of somatotropin. This is a normal process, however, fasting seems to be able to stimulate the production of this hormone.
The reason why humans tend to have more muscles and less fat at a younger age is that human growth hormone has the ability to increase the metabolic use of fats as an energy source. During fasting periods the use of fat for fuel is promoted and the secretion of somatotropin is increased which helps the preservation of muscle mass.
Human body recognizes fasting as a period of low food availability. That is why before scientists feared that fasting can cause the metabolism to slow down significantly. Nowadays, it is known that this is not true.
In reality, the lack of food causes the body to increase the production of noradrenaline, a hormone known for its energy-boosting properties. Higher levels of noradrenaline actually speed-up the metabolism. One theory is that this happens because extra energy is needed to search for food more efficiently.
Electrolytes and Fasting
Fasting equals low food intake. Very often it also means limited food diversity. Both of these factors contribute to a common concern related to fasting – malnutrition.
For a long time, the prevailing opinion in the scientific community was that fasting inevitably leads to a deficiency of essential micronutrients such as:
Recent studies have shown that this is not the case and that the levels of all micronutrients, except vitamins, remain stable even after long periods of fasting. However, high levels of uric acid as a consequence of a protein-based diet are still a concern. Taking a multivitamin while fasting would be a good idea as you will be losing many of the fat soluble vitamins you had stored.
Health Benefits of Fasting
Fasting cycles, such as intermittent fasting, have many scientifically proven health benefits. These benefits are a consequence of a change in the way our body metabolizes food. The metabolic effects of intermittent fasting are best observed through weight loss and reduced insulin resistance which can result in the improvement of certain cardiovascular conditions and diabetes.
Reduced Insulin Resistance
Insulin regulates blood sugar levels in healthy individuals. On a common diet, insulin levels increase in order to regulate blood sugar spikes after eating. Fasting helps blood sugar levels to remain more stable and therefore decreases insulin resistance.
Decreased insulin resistance makes the body more sensitive to the effects of this hormone. This is a positive thing because it enables glucose to be turned into energy and transported to the tissues without big changes in blood sugar levels.
A decreased amplitude of blood sugar levels (fewer spikes and crashes) greatly lowers the risk of diabetes.
Decreased food intake equals a decrease in calorie intake. This is the main logic behind the fasting-induced weight loss. However, fasting also boosts the metabolism and promotes the use of deposited fat for energy while preserving muscle mass.
Increased Human Growth Hormone Secretion
Fasting stimulates the secretion of the human growth hormone (HGH). This hormone is important for the proper development of the body and the overall health. It has an important role in cell reproduction and regeneration. The increased levels of HGH help muscle tissue maintenance which is very important for the success of every weight loss program.
Improved Cholesterol Levels
The use of fat for energy helps to lower the levels of triglycerides and LDL cholesterol (“bad cholesterol”) in the body. In this way, fasting helps to lower the risk of diabetes, hypertension, and heart-related diseases.
Brain Function Boost
Intermittent fasting helps the process of nerve cells generation. This results in an improved cognitive ability (brain function boost). It also slows down neurodegeneration (aging of the brain). Because of its benefits for brain health, fasting is often used as a part of the treatment for certain types of epileptic seizures.
The potentially positive effects of fasting on the damage caused by Alzheimer’s and Parkinson’s disease are a subject of scientific research.
Types of Fasting
Fasting is a common name for many different kinds of eating-related restrictions. The rules of various types of fasting can also differ significantly.
The oldest fasting practices are derived from various religious rules and teachings. Almost every major religion has some kind of a fasting practice related to it.
Muslims, for example, are not allowed to eat or drink anything from sunrise to sunset during the month of Ramadan. Eastern Orthodox churches impose a forty-day fasting period, before Christmas and Easter, during which no foods of animal origin are allowed. There are many more similar examples.
Fasting for medical reasons is very common. It usually involves no food at all and only minimal amounts of water. Fasting may be required before certain medical tests, diagnostic procedures, or surgery.
· Blood tests require fasting the night and morning before testing. The purpose is to obtain the most accurate result. Testing blood sugar levels after eating, for example, will surely result in higher values.
· Colonoscopy is a diagnostic procedure which involves the insertion of a small camera inside the colon, through the anus. It is easy to understand why such a procedure requires a period of fasting. Aside from fasting, colonoscopy usually requires a laxative to completely empty the bowels before the procedure.
· Gastroscopy requires an empty stomach to enable for a better view and lower the risk of vomiting.
· Surgery (general anesthetic). Fasting is always practiced before a planned surgery under general anesthesia. Empty bowel reduces the risk of involuntary contamination of a surgery room by feces as well as the risk of vomiting during oral intubation.
Fasting for medical reasons usually lasts a short period of time. Religious fasting can last longer but it is almost never aimed at solely providing health benefits. For these reasons, this article will focus more on the modern trend of, lifestyle-changing and weight loss related, fasting. Surely, the most popular of these nowadays is intermittent fasting.
Intermittent fasting is experiencing a real surge in popularity lately. It is recommended by many as not only a method to lose weight, but as a good way to permanently change your lifestyle and improve your health.
Intermittent fasting is an eating pattern that allows for time periods of eating but also imposes strict periods of not eating at all. These time periods are either divided as hours during one day or days during a week.
There are several popular styles of intermittent fasting:
16/8 – is a fasting style that divides the day into two cycles. A shorter cycle last 8 hours. During this time you are allowed to consume all your daily calories. For example, this cycle can last from the time you wake up until eight hours later, let’s say 7 am to 3 pm. After this comes the longer cycle that lasts 16 hours and involves sleeping as well. During this period nothing except water is allowed. 16/8 intermittent fasting is usually practiced every day.
5/2 – these numbers relate to days of the week. Basically, this fasting method allows normal eating five days a week and very low caloric intake (no more than 600 calories) during the remaining two days.
Eat-Stop-Eat – is the third type of intermittent fasting. It is possibly the most extreme one. The method involves the so-called “eating days” and “non-eating days”. Every day (24 hours) of normal eating is followed by a day (24 hours) of not eating at all (except water).
All of the methods are mostly designed with weight loss in mind. Needless to say, none of them will work if the caloric intake during eating periods compensates for, or exceeds the energy needs during the non-eating cycles. 16/8 method is the least restrictive, simplest, and the most popular type of intermittent fasting.
Risks Associated With Fasting
Fasting is also associated with certain and more so if some underlying conditions are present or the person that is fasting belongs to any of the high-risk groups, such as:
· Pregnant and breastfeeding women
· Diabetics and people with blood sugar regulating problems
· People with hypotension (low blood pressure)
· Underweight people
Some risks of fasting that can affect healthy individuals:
Hunger is the most obvious and the most common risk related to fasting. Luckily, for most people hunger only last for the first week or so. After this period the body gets accustomed to the reduced quantity of food and switches the primary energy source from glucose to fat.
Binge eating is another risk closely related to hunger. This urge requires mental strength to resist or it can easily turn your attempt at fasting into weight gain.
Weakness, headaches, and fatigue along with the feeling of reduced brain function are common but temporary. These symptoms usually last only for the first 2 or 3 days.
Dehydration is one of the more severe risks related to fasting, but also the one that can easily be avoided since the lack of liquids from foods can be replaced with drinking more water.
Low blood sugar. Blood sugar levels should be monitored regularly during the period of fasting. Although, fasting normally has a positive effect on insulin resistance in cases where some underlying problem exists fasting can cause blood sugar to drop to dangerous levels.
The Final Word
Fasting is a well-known method for losing weight. Even from the mathematical point of view, it is easy to understand why a low-calorie intake leads to weight loss. However, fasting seems to have a deeper and important influence on metabolic processes that take place inside the human body. Currently, this influence seems to bring more benefits than risks and because of that potential fasting should remain a subject of medical research in the future.

domain: medical


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/ FS: DMM Renegade 2 Harness - Size Medium
I have a like new DMM Renegade 2 Harness for sale. Bought for £62 from Manchester Climbing centre last month. After wearing it on a few routes (about 10) I've had to admit to myself that its a bit too big. Still have the little bag and tags that came with it.
Price includes postage.
I'm based in York, regularly at Almscliff on week nights, further afield on weekends. Would take £45 if I don't have to post.
Still for sale if anyones interested?
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Many groomers manually express anal glands during routine grooming. This is called scooting. Mercy has made it clear that the mantel is his space. Knowing what it will take, use caution not to add anger or anxiety to the mix. Hair should always be plucked or stripped before a bath as wet hair is impossible to grasp. He may hunch his body, bottom tucked in and under and he will probably continue to scrape his bottom along the ground in a bid for relief, but it will probably only make matters worse. Simply stop and make arrangements to take him to see his vet.
Grooming & Care
Why on earth would a groomer even USE a muzzle of Gabby??? With the hair removed around the ear canal it is more easily kept free of dirt, moisture and secretions which can cause bacterial or fungal infections. She does a marvelous job and the dogs love her, too. I have subsequently found that it is easier and kinder for the dog to carefully remove the matts using clippers. Keeping the fur around these areas behind ears and under her forearms short, thus preventing further tangles. Let us give them a good scrub to help get back to cuddle statues in you household! When the dog is in motion the tail action is merry.
Puppy’s First Clip | | Dog Grooming Tutorial
Lord help us but we still love them! Annual Awards Achievement Awards Top Dogs Awards Versatility Awards. Above all, he must be free and merry, sound, well balanced throughout and in action show a keen inclination to work. Sign up to our quarterly e-zine for new articles, top tips, competitions and lots more.
Orinda's Premier Dog Grooming Salon
Description: I have found that Miss Rug prefers a shallow bath and I always ensure that the shampoo and conditioner are close by. English Cocker Spaniel Club of Canada members can log in and access newsletters, minutes, and additional information. AKC Dog Ranking 29 th. Your browser is out of date.

domain: pet


San Saba's Sean O'Keefe voted Week 3 Football Player of the Week
San Saba High School's Sean O'Keefe was voted Football Player of the Week for his performance in Week 3 of the season.
The 6-foot-3, 185-pound senior quarterback amassed 320 yards of total offense and accounted for five touchdowns in the No. 3-ranked Armadillos' 63-0 win over Junction.
O'Keefe rushed for 194 yards and two touchdowns — including a career-long 90-yarder — and passed for 90 yards and three TDs while also catching two passes.
There were 6.994 votes cast in this week's poll, and O'Keefe had 2,430 votes.
San Angelo Lake View's Austin Bandy was second with 1,611 votes.
The other nominees were Edgar Nunez from Ballinger, Jorge Rodriguez from Grape Creek, Kevan Covarrubiaz from Eldorado, Clayton Edmiston from Christoval, Alec Lara from Ozona, and Osiel Garza from Irion County.
Voting for the next Player of the Week will begin Monday afternoon.
Ballinger's Tyler Vaughn won the award in Week 1, while San Angelo Central's Kyson Snelson was the Week 2 winner.


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By the time the ink dried on the signing of the USMCA this morning by Prime Minister Justin Trudeau, outgoing Mexican President Enrique Pena Nieto and U.S. President Donald Trump, it was already unravelling.
After the announced loss of 2,500 autoworker jobs at the General Motors plant in Oshawa and many more at plants in the U.S., Trump had already threatened tariffs on cars coming from Mexico as retaliation against the company. Senator Elizabeth Warren has said she will not be supporting the agreement when it comes to a vote in the Senate.
”For decades, the leaders of both parties preached the gospel that free trade was a rising tide that would lift all boats,” she said. “Great rhetoric – except that the trade deals they negotiated mainly lifted the yachts—and threw millions of working Americans overboard to drown”
The Canadian Dairy Farmers and the Steelworkers were urging the government not to sign until the government ensured that the U.S. would not have oversight over Canadian dairy exports and that steel tariffs were removed.
And then, lawyers raced around the clock to finish the incomplete agreement, which is still being changed.
With CETA, the Comprehensive Economic and Trade Agreement between Canada and the European Union, we witnessed many signings. The agreement was tweaked, went through legal scrubbing where negotiators tried to remove objections to the agreement—without success. I suspect this will not be the last signing.
For one, it has to pass the U.S. Congress. There, in the House of Representatives, newly empowered Democrats are determined to make their stamp on the agreement. Already, the Democratic candidate for Speaker of the House, Nancy Pelosi, has argued that there needs to be changes to labour and environmental language in the deal. Some Republicans have objected to LGBTQ language in the agreement (not to be confused with enforceable rights). While some Republicans have asked for a vote in the lame duck session before the House of Representatives returns with a new Democratic majority, this is not likely to happen. What is more probable is that it could be reopened, as Scott Sinclair, veteran trade expert with the Canadian Centre for Policy Alternatives, has noted, by opening the text, or adding “interpretive side letters and/or new assurances about how the deal is to be implemented in each country.”
Which is why we at the Council of Canadians believe the agreement was in no state to be signed.
As Council of Canadians honorary chairperson Maude Barlow said, “This is an agreement with major implications, not a grocery list written on a napkin. With so much political uncertainty and so many poison pills in the agreement, it is better to nail down a complete agreement rather than deal with an agreement that is still in flux. Signing the agreement as is would be giving a blank cheque to Donald Trump. There are glaring problems with the agreement."
I added: “The agreement is one step forward, two steps backward. We are encouraged that some of our historic demands dating back 30 years have finally been addressed. The Council of Canadians was among the first to draw attention to how Chapter 11 would harm our ability to bring in public interest policy and legislation. Now, it is gone—at least between Canada and the U.S., But in the closed-door negotiation of the USMCA, corporations came up with new rights: powers for corporations to monitor and change regulations before they see the light of day in areas that could affect food safety, chemicals, environmental regulations and other matters of public safety. The agreement also supports higher drug prices because of Big Pharma protectionism, and it allows attacks on farmers and Crown corporations. Again, free trade in its current form is a goody bag for corporations.”
Tomorrow, there will be a new Mexican president, the progressive-leaning Andrés Manuel López Obrador, who has done his best to avoid everything relating to USMCA and NAFTA.
American democrats may succeed in demanding environmental and labour rights and have even said they would curtail pharmaceutical companies’ provisions which could raise drug prices. But they are unlikely to fix other glaring holes: assuage the attacks on our dairy farmers, who will have to give up almost 3.6 per cent of their market to U.S. dairies. The deal also caps Canadian dairy exports to the rest of the world.
The Congressional ratification is unlikely to deal with regulatory cooperation which is a whole myriad of rules empowering corporations to participate in how countries regulate. These provisions give business newfound mechanisms to challenge public health and safety regulations. It will probably do nothing to deal with restrictions on crown corporations. Nor will it remove the steel tariffs unilaterally imposed by the U.S, NAFTA, USMCA and WTO be damned.
So, while, we can have some hope that the next Congress will make some changes, we need to ensure that Canada also defends our interest during this process of reopening and re-evaluating this agreement. Remember: it will need to be ratified in Canada probably in the 2019 election year.
For our USMCA quick cheat sheet, see: https://canadians.org/blog/good-bad-and-ugly-nafta-20
Photo: U.S. Department of State, Flickr Media Commons.


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Risk of myocardial infarction and death associated with the use of nonsteroidal anti-inflammatory drugs (NSAIDs) among healthy individuals: a nationwide cohort study.
ABSTRACT Use of some nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with increased cardiovascular risk in several patient groups, but whether this excess risk exists in apparently healthy individuals has not been clarified. Using a historical cohort design, we estimated the risk of death and myocardial infarction associated with the use of NSAIDs. Participants in the study were selected from the Danish population and were defined as healthy according to a history of no hospital admissions and no concomitant selected pharmacotherapy. The source population consisted of 4,614,807 individuals, of whom 1,028,437 were included in the study after applying selection criteria. Compared to no NSAID use, hazard ratios (95% confidence limits) for death/myocardial infarction were 1.01 (0.96-1.07) for ibuprofen, 1.63 (1.52-1.76) for diclofenac, 0.97 (0.83-1.12) for naproxen, 2.13 (1.89-2.41) for rofecoxib, and 2.01 (1.78-2.27) for celecoxib. A dose-dependent increase in cardiovascular risk was seen for selective COX-2 inhibitors and diclofenac. Caution should be exercised in NSAID use in all individuals, and particularly high doses should be avoided if possible.
- SourceAvailable from: Elsayed Ahmed Elsayed[Show abstract] [Hide abstract]
ABSTRACT: For centuries, macrofungi have been used as food and medicine in different parts of the world. This is mainly attributed to their nutritional value as a potential source of carbohydrates, proteins, amino acids, and minerals. In addition, they also include many bioactive metabolites which make mushrooms and truffles common components in folk medicine, especially in Africa, theMiddle East, China, and Japan. The reported medicinal effects of mushrooms include anti-inflammatory effects, with anti-inflammatory compounds ofmushrooms comprising a highly diversified group in terms of their chemical structure.They include polysaccharides, terpenoids, phenolic compounds, andmany other lowmolecularweightmolecules.The aims of this revieware to report the different types of bioactive metabolites and their relevant producers, as well as the differentmechanisms of action ofmushroomcompounds as potent anti-inflammatory agents.Mediators of Inflammation 11/2014; 2014(805841):15. DOI:10.1155/2014/805841 · 2.42 Impact Factor
- Osteoarthritis - Diagnosis, Treatment and Surgery, 03/2012; , ISBN: 978-953-51-0168-0
- [Show abstract] [Hide abstract]
ABSTRACT: Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used in the treatment of pain and inflammation. However, this group of drugs is associated with serious adverse drug reactions. Previously, we studied the mechanisms underlying toxicity of the NSAID diclofenac using Saccharomycescerevisiae as model system. We identified the involvement of several mitochondrial proteins, a transporter and cytochrome P450 activity in diclofenac toxicity. In this study, we investigated if these processes are also involved in the toxicity of other NSAIDs. We divided the NSAIDs into three classes based on their toxicity mechanisms. Class I consists of diclofenac, indomethacin and ketoprofen. Mitochondrial respiration and reactive oxygen species (ROS) play a major role in the toxicity of this class. Metabolism by cytochrome P450s further increases their toxicity, while ABC-transporters decrease the toxicity. Mitochondria and oxidative metabolism also contribute to toxicity of class II drugs ibuprofen and naproxen, but another cellular target dominates their toxicity. Interestingly, ibuprofen was the only NSAID that was unable to induce upregulation of the multidrug resistance response. The class III NSAIDs sulindac, ketorolac and zomepirac were relatively non-toxic in yeast. In conclusion, we demonstrate the use of yeast to investigate the mechanisms underlying the toxicity of structurally related drugs.Toxicology in Vitro 11/2011; 26(2):197-205. DOI:10.1016/j.tiv.2011.11.013 · 3.21 Impact Factor


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Currently unavailable for purchase
Those pesky squirrels know better than to show up when Sylvie the Wonder Dog is on watch. Here she sits under the hanging bird feeder, giving the yellow finches free reign.
JPM © 2009.04.207
home, spring, theme, yard, sylvie, 2009
University of Rhode Island, BFA.Studied at Rhode Island School of Design andS.U.N.Y. Purchase.Major: FilmProficent in printmaking, drawing, painting, pen & ink, poetry, calligraphy, and other stuff.
Such a lovely capture, one to treasure :)
Thanks JackyP :)
– Jack McCabe
Tooooooo precious,love the tiny white flowers to go with her!
nice observation! thx
love the framing! awesome work!
Kris, great observation of subtle elements! Thanks for coming by.

domain: artistic


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Supplementary Material for: White Matter Hyperintensities and Functional Outcomes at 2 Weeks and 1 Year after Stroke
2013-02-07T00:00:00Z (GMT) by
Background: Many stroke survivors remain at a functionally disabled state. Early prediction of functional outcome is an important step in the treatment and care of stroke patients. Brain imaging measures have received particular attention as one of the predictors of stroke outcomes. However, the associations between white matter hyperintensities (WMHs) and post-stroke recovery have been controversial. This study aimed to investigate whether deep and periventricular WMHs (DWMHs and PVWMHs, respectively) were associated with functional outcomes at 2 weeks and 1 year after stroke separately and interactively. Methods: A total of 408 patients were evaluated at the time of admission and 2 weeks after stroke, and 284 (78%) were followed 1 year later in order to evaluate consequences of stroke at both acute and chronic stages. Stroke outcomes were dichotomized into good and poor by applying a modified Rankin Scale (mRS) score cutoff of 1 (no significant disability)/2 (slight disability). Measures of stroke severity (National Institutes of Health Stroke Scale: NIHSS), physical disability (Barthel Index: BI), and cognitive function (Mini-Mental State Examination: MMSE) were administered. Brain magnetic resonance imaging (MRI) was performed at admission. DWMHs and PVWMHs were rated visually on axial FLAIR images using the 4-point modified Fazeka’s scale and categorized into mild (grades 0 and 1) or severe (grades 2 and 3). The demographic and clinical covariates of age, gender, years of education, previous history of stroke, depression, stroke location, and vascular risk factors were obtained. Associations of WMHs with stroke outcomes (mRS) and other measures (NIHSS, BI, and MMSE) at 2 weeks and at 1 year after stroke were investigated using logistic regression and repeated measures ANOVA after adjustment for the potential covariates. Results: Severe PVWMHs, but not severe DWMHs, were significantly associated with worse outcomes both at 2 weeks and at 1 year after stroke. Furthermore, significant interactive effects of PVWMHs and DWMHs on poor outcomes were found. Significant PVWMH group by time interactions on NIHSS and BI scores, and significant group effects of both DWMHs and PVWMHs on MMSE score were found. Conclusions: PVWMHs predicted poorer functional outcomes after stroke both in the acute and chronic phases, independently and interactively with DWMHs. In addition, PVWMHs were independently associated with worsening of stroke severity and physical disability. More careful evaluation and management of stroke patients with a high risk of functional dependence are indicated. Overall, PVWMH might be a prognostic marker of short- and long-term stroke outcomes.


OTTAWA — Prime Minister Justin Trudeau is promising to be flexible and fair with billions in new infrastructure money as mayors from the country’s biggest cities press the Liberals for carte blanche on the new cash.
The details around how cities will be able to use the promised new infrastructure money will be unveiled in the budget.
tap here to see other videos from our team.
Trudeau said the new program — valued at $60 billion over the next 10 years — would meet the needs of communities and get money “flowing in a responsible and rapid way.”
“Cities across the country have varied and diverse needs and we’re meeting with them, we’re talking with them about where their priorities are and how best we can create opportunities for Canadians and growth for the medium and long-term,” Trudeau said.
Trudeau and the mayors billed their talks on Friday as building a new deal for cities.
In their meeting with Trudeau, the mayors of Canada’s largest 21 cities urged the federal government to ensure the provinces don’t hold up funds.


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A Catholic bishop has warned that the same arguments which are now being used to justify abortion will be used to justify ending the lives of frail older people and individuals with significant disability.
Bishop Kevin Doran has also said that simply removing the Eighth Amendment to the constitution - as recommended recently by a special Oireachtas Committee - would leave governments entirely free to introduce whatever abortion regime they choose at any time in the future.
Sligo-based Bishop Doran, who chairs the national Catholic bishops' bioethics committee, makes his comments in a pastoral letter to his diocese of Elphin two days ahead of a special cabinet meeting on the terms of the promised referendum on the repeal of the Eighth Amendment's near-blanket ban on abortion.
"This is the final frontier," the bishop declares. "If we cross it, there will be no easy way back."
He adds that if the electorate were to simply remove the Eighth Amendment - as advocated recently by an Oireachtas Committee - governments would be left entirely free to introduce whatever abortion scheme they choose at any time in the future.
He warns that promises made before the referendum would not be binding and accuses the committee of asking citizens to give the government a blank cheque.
The bishop urges members of his diocese to politely lobby their politicians to defend the right to life of the unborn.
And he advises any member his diocese who may be uncertain about how to vote - or what to do - to pray daily for the gift of wisdom, and to allow what he calls "God's Spirit" to be their guide.
The diocese of Elphin covers parts of Counties Sligo, Roscommon, Westmeath and Galway.

domain: law


I need an updraft B&S carb that will work with my 6HP original engine. If the carb is original or not, no concern, just needs to work. If anyone can help me I would appreciate it.
Also, what is the possibility of finding the parts needed to create the rear PTO drive?? Is this something that can be found or do I just forget about that idea?
Thanks in advance guys!!


I read yesterday that researchers at Vienna University’s Faculty of Psychology, after 15 years of examining the data, have determined that there is no provable connection between listening to Mozart and increased intelligence – the so-called ‘Mozart effect’. This does not surprise me. I would have been astonished if such a thing could be scientifically verified, not just because I’ve met many musicians who were not particularly bright, but because the whole issue of intelligence as something measurable is open to question. Indeed, many areas of psychology itself remain stubbornly beyond proof.
But not any more. Ivan Hewett describes how he belatedly woke up to the ‘tender poet’ of the piano.
The flood of Chopin performances and recordings launched by the 200th anniversary of the composer’s birth shows no sign of abating. In the next few weeks Alexander Tharaud, Leon McCawley and Louis Lortie are all giving Chopin concerts, to name just three. As for the recording industry, it’s thrown caution to the wind. In recent weeks there have been new releases from Nikolai Lugansky, Stephen Hough, Nelson Freire, Yundi. The list is endless.
But Chopin hasn’t always swept away those before him. Even now many people feel a deep resistance to him and for years I did, too. When I was just starting to explore classical music I naturally gave Chopin a try and had an instant aversion to him. Those melting runs and arabesques made me feel physically sick, and I instantly translated this “yuck” sensation into a moral judgment.


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Please use this identifier to cite or link to this item:
|Title:||Synthesis and characterization of some sulfonamide based bis-sydnones and their in vitro antimicrobial activity|
|Authors:||Asundaria, Shahrukh T|
Patel, Keshav C
|Abstract:||4-Sulfonamide substituted novel sydnones have been synthesized. The synthetic strategy utilizes 4,4′-diaminodiphenylsulfone as starting material to obtain the 3,3′-(sulfonyldi-4,1-phenylene)bis(4-chlorosulfonyl)sydnone 6 through several steps viz. esterification, hydrolysis (saponification), nitrosation, cyclisation and chlorosulfonation, which are then condensed with different secondary amines to get final compounds. All new compounds have been characterized by spectral data as well as elemental analysis and have been tested for their antibacterial activity against gram positive S. pneumoniae and S. aureus, and gram negative bacteria E. coli and P. aeruginosa. Some of the synthesized compounds show excellent antimicrobial activity.|
|Appears in Collections:||IJC-B Vol.49B(07) [July 2010]|
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What 7764 is that? Let´s find out step by step.
After long time not seeing another discovered Skipper in the Autavia compressor case now another one popped up. The Skipper worked hard on Regattas but is still in good shape – the engraving on the case back is still visible and the bezel just got some minor scratches!
And our friend Manuel took the chance to catch this gem.
Let´s introduce a Heuer Skipper 7764 in an Autavia compressor case with “normal” hands and with a serial that fits perfect in the line – and it is the most early one.
It is not only the very early serial that makes this Skipper really fantastic – it is the story behind this toolwatch.


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The 4th of July, a time to celebrate everything red, white and blue!
And what better way to honor America than a good old- time ditty from legendary American songwriter George M. Cohan!
Performed by none other than the Sockies!
Wait, you don’t know who the Sockies are?
Well, it’s time you found out! Enjoy and don’t be afraid to join in!
Nothing like a good old dose of American spirit, is there? And in case you need more here’s another flag waving animation that’s sure to rouse the patriot inside you.
Be sure to share the stars and stripes this Independence Day. Happy 4th of July everyone!
Oh, and be on the look out for more from the Sockies. You’ll never know when they’ll turn up.

domain: entertainment


In today’s world, where pollution and airborne contaminants are becoming increasingly prevalent, ensuring clean and healthy air is vital for our well-being. HEPA filters play a crucial role in achieving this goal by effectively removing harmful particles from the air. This article will explore what HEPA filters are, how they work, and the various benefits they offer in enhancing air quality and promoting better health.
Table of Contents
Understanding the Significance of HEPA Filters
HEPA stands for High-Efficiency Particulate Air, and HEPA filters are designed to capture and trap airborne particles as small as 0.3 microns with high efficiency. These filters are highly regarded in air purification systems for their ability to remove dust, pollen, pet dander, mold spores, bacteria, and other pollutants from the air we breathe.
How Does a HEPA Filter Work?
A HEPA filter consists of a dense mat of fibers arranged in a pleated pattern. As air passes through the filter, the fibers create a labyrinthine path that forces particles to collide and stick to the fibers. This mechanism, known as diffusion, intercepts particles and prevents them from re-entering the air.
Capturing and Removing Airborne Particles
HEPA filters are extremely effective at capturing a wide range of airborne particles. The filter fibers, made of materials like fiberglass, randomly trap particles through three main mechanisms: interception, impaction, and diffusion. These mechanisms ensure that even the smallest particles are trapped within the filter.
The Efficiency of HEPA Filters
HEPA filters are known for their exceptional efficiency in capturing particles. They can remove up to 99.97% of particles that are 0.3 microns in size or larger. This high level of efficiency makes HEPA filters an ideal choice for individuals concerned about indoor air quality.
Applications of HEPA Filters
HEPA filters find applications in various settings, including homes, offices, hospitals, laboratories, and manufacturing facilities. They are commonly used in air purifiers, HVAC systems, vacuum cleaners, and cleanrooms, where maintaining a high level of air purity is essential.
HEPA Filters for Allergies and Asthma
For individuals with allergies or asthma, HEPA filters can provide significant relief by removing allergens and irritants from the air. These filters effectively capture common triggers such as pollen, dust mites, pet dander, and mold spores, helping to create an allergen-free environment.
HEPA Filters in Commercial and Industrial Settings
Beyond residential use, HEPA filters are vital in commercial and industrial environments where air quality is crucial. Industries such as pharmaceuticals, electronics, and food processing rely on HEPA filters to maintain clean manufacturing spaces and prevent contamination.
Maintenance and Replacement of HEPA Filters
To ensure optimal performance, regular maintenance and timely replacement of HEPA filters are necessary. It is recommended to follow the manufacturer’s guidelines and schedule regular filter inspections, cleaning, and replacements as required. This will help maintain air quality and prolong the lifespan of the filters.
HEPA Filters and Indoor Air Pollution
Indoor air pollution can have detrimental effects on our health. HEPA filters are an effective solution to combat indoor air pollution by capturing pollutants such as smoke, volatile organic compounds (VOCs), and fine particles. Using HEPA filters in indoor spaces helps reduce the risk of respiratory issues and improves overall air quality.
HEPA Filters vs. Other Air Filtration Methods
While various air filtration methods exist, HEPA filters are considered one of the most efficient options. Compared to standard filters or electrostatic precipitators, HEPA filters offer superior particle capture and removal capabilities, ensuring cleaner and healthier air.
The Importance of Regular Cleaning and Maintenance
Proper maintenance of HEPA filters is essential for optimal performance. Regular cleaning removes accumulated particles and ensures the filter can continue to operate efficiently. Additionally, it is important to seal any leaks or gaps in the filtration system to prevent air bypassing the filter.
HEPA Filters for Pet Owners
Pet owners often struggle with pet dander and allergens present in their homes. HEPA filters can effectively capture these particles, reducing allergies and improving indoor air quality. When combined with regular pet grooming and cleaning practices, HEPA filters provide a significant advantage in maintaining a clean and healthy environment for both humans and pets.
HEPA Filters and Smoke/Fire Particles
In the event of a fire, smoke particles can pose a severe health risk. HEPA filters can help mitigate the impact of smoke particles by capturing and removing them from the air. This is particularly crucial for individuals with respiratory conditions or those living in areas prone to wildfires.
Cost Considerations of HEPA Filters
While HEPA filters offer exceptional air purification capabilities, it’s important to consider the associated costs. HEPA filters generally have a higher initial cost compared to standard filters, and they require periodic replacement. However, the long-term benefits they provide in terms of improved air quality and better health outweigh the costs for many individuals.
What is the lifespan of a HEPA filter?
HEPA filter lifespan varies depending on usage and environmental conditions. On average, they last between six months to two years. It’s important to follow the manufacturer’s guidelines for replacement.
HEPA filters play a vital role in enhancing air quality and promoting better health. By efficiently capturing and removing airborne particles, these filters provide clean and purified air for various settings, from residential homes to commercial and industrial spaces. Investing in HEPA filters can significantly improve indoor air quality, reduce the risk of allergies and respiratory issues, and create a healthier environment for everyone.


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Search over 1 million properties and 550 airlines worldwide
Free cancellation on most hotels. Because flexibility matters.
Visitors can enjoy all that Harwich has to offer including the waterfront, museums and theatres. Tourists can also enjoy so much more including its bars. Top sights around the area include Ipswich Waterfront and Chantry Park.
Cultural venues in the city include Lifeboat Museum, Old Harwich Lighthouse and Harwich Maritime Museum. Additionally, you might want to add Beacon Hill Fort to your agenda.
As you plan your holiday retreat, you'll find 11 hotels and other accommodation options to select from in Harwich. These are top ranked ones based on our user reviews:
Top places to see outside the city include Colchester Zoo, located 20.1 mi (32.3 km) from the city centre, and Ipswich Waterfront, which is 9 mi/14.5 km away.
With so many ways to get around, exploring Harwich is simple. If you'd like to explore more of the area, hop aboard a train from Harwich Town Station, Harwich Dovercourt Station or Harwich International Station. You can catch a ferry and cross the water to see more of the region.

domain: travel


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We all know the horrendous images of mountaintop removal in Appalachia and the devastation it has incurred on communities, watersheds, livelihood and overall human health and wellbeing. This is not new information.
For generations, coal companies have paid off landowners to get what they want. They come into a community knowing they will not play by the rules, but by the set of rules that enables them to pursue corporate profit to benefit the 1 percent. These ruthless acts of selfish greed force communities to take a side.
Riversdale Alaska LLC (formerly part of corporate mining giant Rio Tinto), an Australian company, currently holds the Mental Health Trust land lease for 10,000 acres of land in Chickaloon, which consists of prime moose habitat, plush berries, medicinal wild plants, recreational use, pure and aesthetic beauty and the entire watershed that surrounds the community of Chickaloon.
The Mental Health Trust is in bed with the DNR to lease the land to make money for mental health. All the Mental Health Trust is really doing is creating a mentally ill community and using the proceeds to help treat its beneficiaries, the mentally ill. Sound moronic?
In the past two weeks, Riversdale has hired FUGRO, a Canadian company, to fly two ERA A-star helicopters over Chickaloon in grid pattern doing electromagnetic readings with a submarine-like unit hanging from the helicopter. Multiple landowners have called the FAA reporting that FUGRO has been flying out of compliance and hovering dangerously low over residences barely above treetop.
This humdrum buzz of helicopters has created a stressful sense of paranoia and inability to live our lives in peace and quiet. There is no reason for the flight patterns directly over local homes. Riversdale promised this would not happen; however, corporate wealth seeking foreign companies don’t keep promises.
In addition to flying helicopters over our community, Riverdale has been on the fast track to buying out locals this week. The Chickaloon Village refused an offer from Riversdale to be bought out. However, they have bought out a few Chickaloon residents in exchange for a water well, landing and storing private helicopters on private land, and fixing our “private access” back road that connects one side of our community to the other.
Riverdale paid T and J’s in Wasilla to fix up the non-borough maintained road without notice to landowners, our community council or waiting for its exploration permit to be permitted. Riversdale is already acting like every other foreign coal company and doing what it pleases. It is commonplace for rich multi-nationals like Rio Tinto to buy out and suppress locals by dummying down their intelligence and convincing them they need a little candy money. However, this addiction to a “better, more prosperous life” feeds ignorance and dependence on unsustainable and destructive habits. Every example in history shows how coal destroys communities, leaves a toxic mess and only fills pockets of the corporate slaves.
In this particular situation, the MHT has sold out to a foreign coal company with plans to send coal to China or Japan. This foreign company plans to use our one and only local road in Chickaloon, but does not pay any tax to the borough. This is commonplace for rich multi-national resource development corporations. They have no investment in the community, but instead think they can buy people out to create a “better” future. Forcing neighbors to sell out creates a horrible dynamic within a community.
I did not move here because I wanted a “better” life someday. I did not move here with hopes of getting paved roads in the future, a school or even fire service. I moved here because Chickaloon is what it is. Chickaloon consists of a unique variety of people who moved and settled here for various reasons. The main reason being the stunning beauty of Castle and King mountains, quiet peaceful nature, ability to live simply and abundantly with little income from real wild resources like wild game, salmon, berries and plants, and the strength of a community that loves, respects and cherishes its home.
We did not move here for jobs. We moved here to live a mostly subsistence and modern-day homestead lifestyle. This lifestyle is threatened by coal exploration. I have worked every hour of every day for the past 10 years on this land to create a livelihood that benefits the land, my community and my family. No one can begin to understand the motivation, dedication and determination necessary to make and do everything for yourself — especially a company like Riversdale. We do not have a price tag and will not be bought or sold. Any prospects Riversdale has of convincing locals of a better life with its Aussie dollars is blind to the reality that the price tag carries a weight that will drag us down for decades to come.
Just ask Riversdale how well liked it is at home in Australia, where the company forced farmers to sell out for greedy corporate interests. Research Riversdale’s swindling and community relocation efforts in Mozambique for its resource development profits. Riversdale’s only skills are manipulation, intimidation and corruption. It knows how to get what it wants and leave us with the mess.
If resource development enthusiasts really think mining coal in this beautiful and unique Matanuska Valley is a good idea, perhaps they should visit China or West Virginia to see for themselves. Smog, toxic air and heavy metal contaminated water, coal dust, compromised health and inevitable impacts to the land, its inhabitants and communities are not included in the Chickaloon Community Comprehensive Plan. Supporting coal creates more of a dependency on consumer culture. Until we change the unsustainable and dangerously false paradigm from coal benefiting our communities to the real truth pointing toward its real long-term impacts, community members will continue to be bribed and beaten down into giving up everything they have worked and lived for.
Riversdale is ripping out our hearts and expects us to kneel down begging for forgiveness in the form of a check with multiple zeros. Riversdale should go back to Australia and stop forcing our community to sell out. Stop creating consumption for corporate profit without considering community.
We choose to live deliberately and intentionally in this beautiful valley that provides our livelihood and not walk down the desperate path of sorrow. Go home, Riversdale, and take the easy way out.
Allie Barker is a Chickaloon resident.

domain: geography


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MSc Sound + Music for Interactive Games, BA Music Production
Sound designer for games, & freelance composer. Currently working remotely from my home studio in Dublin, Ireland with intention to relocate to the UK.
I recently finished designing additional audio for upcoming cyberpunk narrative game Neuroet: Mendax Proxy (Dream Harvest, UK). The player must embark on a journey of self-discovery in contril of an AI as you learn what it means to be human in a world losing itself to technology. My role was to create audio assets for the in game narrative cards on 11 of the game locations. This included bringing the characters and environment to life with sound which reflected the actions, locations, characters and aesthetic of the cyberpunk art style.
Coming in 2022 to PC, mobile and nintendo switch


Renault and Red Bull's already tense relationship just got a bit more strained with the engine manufacturer's boss claiming the F1 team are "lying" about certain issues.
The two parties have endured an uneasy partnership over the past year as Red Bull have fallen well off the pace of Mercedes with the Milton Keynes squad insisting that most of their woes are down to Renault's inability to come to grips with the turbocharged 1.6-litre V6 engines.
Red Bull designer Adrian Newey, who has taken a back seat this year after playing a major role in helping the team to four back-to-back World titles, suggested ahead of the Australian GP that their engine partner "doesn't seem willing to engage" so that they can sort out their problems.
"It’s one thing being in the position where you’re not competitive but you can see your way out of it. It’s another thing when you’re not competitive and your partner doesn’t seem to be willing to engage," he told the Guardian.
"I honestly don’t know the reason for it. It seems to be: ‘Yes, we hear you say’, talk. In pre-season testing, we had 12 days and a filming day in which I think we had six major failures. So our mileage was very restrictive through engine problems and as measured by the torque sensor through those tests, the power we have is exactly the same as last year."
His comments have drawn an angry response from Renault managing director Cyril Abiteboul.
When asked by Auto Hebdo about Newey's comments, he replied: "Yes, it's difficult to have a partner who lies. Adrian is a charming man and an engineer without parallel, but he's spent his life criticising engine partners. He's too old to change his ways."
Despite the tension, Abiteboul though once again called on both parties to work together.
"We need to work together to understand our issues, both within the power unit and the chassis," he said in a Renault statement. "Our figures have shown that the lap time deficit between Red Bull and Mercedes in Melbourne was equally split between driveability issues, engine performance and chassis performance. It's therefore the overall package that needs some help and we have been working with the team to move forward.
"We've been particularly aggressive in development and we should see the results a lot more clearly in Malaysia, particularly since we have had the opportunity to refine the PU using the data from Australia. Work is still ongoing but even now we are in a completely different place to where we finished Melbourne."