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Hi there! Welcome to GlobalDerm HomeoPatch – Leader in Transdermal Patch Technology
Did you know that transdermal delivery and release systems
Transdermal delivery and release systems have been on the market since the 80′s. That’s almost 40 years of extensive research put into this technology. Most major pharmaceutical companies market Transdermal systems for dispensing medical agents and other solutions, including the well-known anti-smoking Nicotine patch.
GlobalDerm HomeoPatch patches are made of premium quality ingredients in the USA from FDA approved sources using a proprietary process and are food supplements that are completely safe for human consumption. Patches are hypoallergenic, vegan, do not contain any Latex, and are gluten-free.

domain: medical


The Liberal Party coup plotters have done a brilliant job over the past few days, at least if their starting goal was to convince as many voters as possible that they could not care less about the business of running the country.
A basic tip for any coup plotter since the days of Brutus and Cassius is to use the element of surprise. After a brief night of long knives, the public should wake up to safe streets and images of the new leader on television.
Instead, former Homeland Affairs minister Peter Dutton has dragged out a slow motion coup, now crawling into its fourth day. After he came close to winning the prime ministership in a surprise spill at a Liberal Party caucus meeting, he could have made a tactical retreat to the backbench, waiting to strike again at a moment of his choosing.
Goaded and abetted by the insatiable vampires in the right wing of his party and the media, Mr Dutton, however, rushed to demand an immediate second vote. Except Mr Dutton lacked the numbers to call an emergency vote and without them it was not Mr Dutton's prerogative but party leader Prime Minister Malcolm Turnbull's.
This predictable impasse led to the farce on Thursday where, lost in the hunt for the magical 43 signatures needed to call a meeting and unable even to field a front bench, the government closed down the House of Representatives. So much for working in voters's interests. And still the agony continues.
Mr Turnbull, who perhaps still has some faint hope he can save his own skin, has delayed calling a meeting until the party resolves the other huge and entirely predictable hole in Mr Dutton's cunning plan: The question of whether he is constitutionally eligible to serve as an MP despite the childcare contracts his family trust has with the government.
As of Thursday evening, there is no certainty that the meeting on Friday will even take place. It depends on Mr Dutton heavying enough wavering MPs into signing up and an all-clear from the solicitor general about his status under section 44 of the constitution.
At best the party will have wasted four sitting days on this private costume drama. At worst it is possible that the whole coup collapses or limps along unresolved after the meeting.
Or it is still possible that a dark horse, such as Deputy Leader Julie Bishop or Treasurer Scott Morrison, will make a run on the inside rail on Friday. The idea that the prime minister is democratically elected by the people has long since been scratched from the race.
What the past four days have failed to do is explain what is driving this coup other than naked ambition. This is an entirely self-inflicted crisis. The economy is going fine and the government was only slightly behind in the polls. Unlike the past three times a sitting prime minister was dumped, Mr Turnbull is better liked by the public than Mr Dutton.
It appears the Liberal Party is trapped in an identity crisis. As Mr Turnbull said on Thursday, a rump of Liberals and their media backers want to pull the party towards the right. Some want to relitigate the marriage equality debate or perhaps decisively reject climate change. Yet the Liberal Party seems to be losing its very soul as a broad church with a simple commitment to small, efficient government and low taxes. It is now looking like a rabble.


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Printed on: Dec 11, 2013
Draped Strapless Dress
Sorry, this item is no longer available!
- Online exclusive
- Pleated bodice with stretch topline, silicone gripper
- Inset waist with wrap-look skirt, tulip hem
- Exposed back zipper
- Fully lined
- Measures approximately 28" from center back top edge to bottom hem
- 100% Polyester
- Machine wash, gentle cycle. For best results dry clean.
If only the friction tape at the top would stay I really love this dress on, however, the friction tape that lines the top of the dress constantly rolls out. If this line would have been tacked down to prevent rolling, this would have been a perfect dress. I do recommend wearing nude undergarments as darker undergarments show through a bit. Nude ones work well. I found this dress true to TL sizing. I really wish it would have worked out because the color and the fit are well represented in this picture. June 13, 2013
Great dress but... Color is very bright but still looks good. Size fit perfect. Love the dress but its see through even with nude under garments. I was disappointed but I had to return the dress. May 9, 2013
too loose around the chest for those like me with small bubs lol... not good. it looks like a bag.. (and I'm not that small either). I love the style and fit at the bottom but... had to send it back. May 4, 2013
Terrible fit and VERY bright The color is much more vibrant than pictured, and the fit is awful. The material over the bust is excessive, poofy and not flattering at all. I can't imagine this looking good on anyone, no matter what size. April 17, 2013
1-4 of 4

domain: design


Scale Aircraft Conversions | #32092 Arado Ar 234B Landing Gear (Fly)
Reviewed by Ray Peterson
This recent release from Scale Aircraft Conversions is a new accessory set for the recent Fly 1/32nd Arado Ar 234B kit. The set includes the main landing gear and nose gear fork as well as separate bracing.
This set is simply meant to be a direct replacement for the kit’s plastic landing gear, providing the modeler the option to go with white metal instead of plastic. While the casting is quite good, most of the details are unchanged and any defects of the kit parts, such as molding seams, are therefore replicated on the SAC gear.
I still am not happy with the softness of the alloy used. While the main gear should be plenty strong, I am worried a bit by the nose wheel fork. It is a bit spindly and bends easily. There should be little weight on the nose, however. Clean up of seams in this material will be difficult, and the soft alloy will bend easily, so be careful.
Recommended with reservations.
Thanks to Scale Aircraft Conversions for the review set.
© Ray Peterson 2016
This review was published on Saturday, May 07 2016; Last modified on Sunday, May 08 2016


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The Brave+True label has cemented itself as one of Australia’s most loved womenswear brands.
The collections are made for every day, every night, every age, every style, every size, every occasion and every woman. We are inspired by all the exceptional women in our world who are trying to balance their daily responsibilities and still feel beautiful, confident, and supported.
The Amba Black & White Stripe Tank features:
- Knit top with ribbing around neckline and armholes
- Stylish contrast stripe pattern
- Easy fitting silhouette


text:
A Dictionary of Literary Symbols - Michael Ferber
Works on PC, Mac and modern smartphones and tablets!
- Create an Adobe account.
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Buy this book on TRADEBIT.COM.
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Standard iOS and Android reader apps work, too!
Author: Ferber, Michael
Publisher: Cambridge University Press
Title: A Dictionary of Literary Symbols
Pages: 00273 (Encrypted PDF)
On Sale: 1995-11-03
Category: Literary Criticism : Reference
Category: Reference : Dictionaries - General
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domain: library


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The Medical Team attending to President Edgar Lungu, have recommended that the President undergoes a high-tech medical procedure which is currently unavailable in Zambia.
The Doctors have therefore referred President Lungu for specialised treatment abroad.
This is contained in statement made available to ZANIS in Lusaka today by Special Assistant to the President for Press and Public Relations, Amos Chanda.
Mr. Chanda further explained that the Medical Team has explored options of correcting the narrowing of the food pipe that led to the illness of the President on Sunday March 8th 2015.
He said a team of senior doctors comprising physicians, surgeons, pathologists, and radiologists, reviewed these findings and recommended immediate correction of this condition.
He said as announced earlier President Lungu has a history Achalasia , the condition of the narrowing of the food pipe which was corrected 30 years ago at the University Teaching Hospital and appears to have recurred.

domain: news


Hey, I thought that jobs bill of President Obama’s was urgent. He said Congress needs to pass it right away, like, now! Apparently, he hasn’t been communicating with Senators from his own party, because they aren’t going to consider the bill until next month, after another vacation.
Well, here we are on the next Monday after that next Monday and we’ve just learned from the No. 2 Democrat in the Senate, Dick Durbin, that actually it seems that body won’t really be seriously getting into the legislation for a while yet. The Senate has some other more important business to handle. And then there’s this month’s congressional vacation, which in Washington is called “a recess,” like elementary school.
Here’s the revealing exchange with a persistent host Candy Crowley on CNN’s “State of the Union:”
CROWLEY: When is the bill going to get on the floor?
DURBIN: The bill is on the calendar. Majority leader Reid moved it to the calendar. It is ready and poised. There are a couple other items we may get into this week not on the bill and some related issues that may create jobs. But we’re going to move forward on the president’s bill. There will be a healthy debate. I hope the Republicans will come to…
CROWLEY: After the recess, so next month? Or when will it actually begin to act on?
DURBIN: I think that’s more realistic it would be next month.
So, as of right now, “right now” uttered on Sept. 8 really means sometime at least one month later. (Read More)
Not to worry, the president will unveil his deficit reduction plan, that includes $1.5 trillion in tax increases, in just a little while. I’m sure he’ll tell us it’s urgent. Maybe the Democrat controlled Senate will take it up some time after Christmas, just in time for the 2012 election.


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Lavon Eblen speaks with Alayna Clancy with the Audubon County Hospital Foundation about a Concert Sunday afternoon to celebrate their 20th anniversary.
Jim Field speaks with Brian Waddingham, Executive Director of the Coalition to Support Iowa’s Farmers, about National Agriculture Day.
w/ Kate Olson
The (podcast) Freese-Notis weather forecast for the KJAN listening area, and weather information for Atlantic.
Lavon Eblen speaks with Jim Olson, Director of the Iowa Waste Reduction Center @ University of Northern Iowa about “Food Waste: A multi Faceted Problem”


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Dr. House was part of a team of 24 scientists from ten countries at the at the International Agency for Research on Cancer in Lyon, France, in order carcinogenicity of carcinogenicity of shift work, painting and fire fighting. The working group analyzed several epidemiological studies and animal experiments get information . Ngs on shift work she determines that total occupational exposure as a painter is carcinogenic to humans. You have also classified occupational exposure as a firefighter as possibly carcinogenic to humans. A preliminary report published by the WHO International Agency for Research on Cancer in Lancet Oncology, .
The most serious type of heart attack known as ST-segment elevation myocardial infarction . A STEMI, critical arteries blocked the heart with blood. Previous studies have shown, that the best treatment for patients STEMI reperfusion – if a patient blocked artery is opened by inflating a balloon at the site of the blockage or by delivering clot – dissolving drugs, so that the restoration of the blood flow to the heart muscle. Continue reading “In order carcinogenicity of carcinogenicity of shift work get information.”
There are currently more than 1,400 CoC – approved cancer programs in the U.S. And Puerto Rico, which is almost 25 % of all hospitals. This CoC facilities diagnose and / or treat 80 % of newly diagnosed cancer patients per year. This designation is another step in our goal of the best possible care for cancer patients in North Texas, said Dr. James Willson, director of the Harold C. Simmons Comprehensive Cancer Center at UT Southwestern. It also highlights our collaborations among programs in clinical care, research and prevention. .
Approval by the CoC is only those facilities that have voluntarily undergone the highest level of quality of cancer care and a review of their performance are given required. To obtain approval, facilities must be on-site every three years. Continue reading “There are currently more than 1.”
School-age children ADHD in the school needed – About 80 percent of teachers surveyed Want More ADHD Training, UKA new survey has revealed that more than half of the British teachers have no training on attention deficit hyperactivity disorder read more . With millions of UK children go back to school this month, that finding colors. A poignant image for an estimated 5 percent of school-age children in the UK who have ADHD These results are. Particular about the teachers as most are common source of support in the UK for 70 percent of parents of children with ADHD.
To adhere Tickbox.net and follow the codes of the MRS and are fully registered and compliant with the Data Protection Registrar.References 2008 tickbox Survey: Data on file ConcertaXL_DoF_01Sep2008_MI_JCJ_01  NICE 2006 atomoxeine methylphenidate, and Dexamfetamine for attention deficit hyperactivity disorder in children and adolescents, Technology review 98th Review the Technical Review 13 National Institute for Health and Clinical Excellence. Continue reading “ With millions of UK children go back to school this month read more.”

domain: health


In an effort to cater to the Spanish-speaking borrower demographic, reverse mortgage originators are now able to access Spanish language loan documents through a new service offered by Mortgage Cadence.
Finale Document Services now includes reverse mortgage document packages in Spanish in addition to English, to align with the needs of a growing Spanish-speaking borrower demographic.
“There have been requests from both customers and prospective customers, and we anticipate there will be additional growth in this underserved demographic segment,” Jacob Petersen, Finale executive vice president told RMD in an email.
“It is no secret that the Hispanic growth over the last decade has accounted for nearly half of the United States’ growth, and as such, this population is poised to become the next powerhouse,” Petersen said. “Also this was a client-driven initiative that tied directly into the Hispanic growth.”
Finale worked with a law firm in Puerto Rico to develop the disclosures and documents, with an eye toward market expansion. The company has the ability to add additional Spanish documents to meet state specific Spanish disclosure requirements as well.
Lenders, too, have increased efforts recently in marketing to the Spanish-speaking demographic, and Puerto Rican lender Money House has announced it is seeking to expand into the United States in 2012 either through an acquisition of a lender in the U.S. or the opening of a new location.
Written by Elizabeth Ecker


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H. Scot Krause is a gaming industry analyst, researcher and journalist. He is a former entertainment director and 18-year resident of Las Vegas.
Reel Deals | The Downtown Grand is hosting Spin and Win Casino Wheel every Friday and Saturday night, March 2-31. Drawing times will take place every hour on the hour 7-9 p.m. To qualify, participants must have active carded play during the hours of the promotional period.view
Poker Profile | Atlantis Casino Resort Spa in Reno has its All In Poker Series coming up March 15-25, featuring a $200,000 Main Event guarantee. So we interviewed Keith Dames, Atlantis poker room manager, about the big event and what’s going on at Atlantis.view
Reel Deals | Silverton, the popular off-Strip casino is now home to Nevada’s first Lightning Link Lounge, a space on the casino floor dedicated exclusively to the new extremely popular video slot game, Aristocrat’s Lightning Link. The Lounge houses 36 games, is conveniently located in the former slot tournament room, and was created to respond to customer demand.view
Slot Club Spotlight | Truckee Gaming, LLC is a Reno based gaming company that now owns and operates five casinos in the Northern Nevada Region with over 45,000 square feet of gaming space. They recently completed the acquisition of three casinos and additional land owned by Pioneer Crossing Casinos, LLC.view

domain: entertainment


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Glen Retief is an Associate Professor of nonfiction writing at Susquehanna University. His The Jack Bank: A Memoir of a South African Childhood won a Lambda Literary Award.
THE JACK BANK | GLEN RETIEF
* Winner of a Lambda Literary Award and an Africa Book Club feature in 2012
An extraordinary, literary memoir of a gay white South African, coming of age—and realizing he’s attracted to black men—at the end of apartheid, during the 1980s and early 90s.
Glen Retief’s childhood was at once recognizably ordinary—camping with his brother and sister, playing soldiers with the kid next door—and brutally unusual. Raised in the middle of a game preserve where his father worked, Retief experienced his warm nuclear family as a preserve of its own, protection against chaotic forces working just outside its borders: a childhood contact who taught Retief how to use police lingo on walkie-talkies was also the leader of a death squad, killed human rights activists, and dumped their bodies in crocodile-infested rivers.
But it was only at twelve, when Retief was sent to boarding school, that he was truly exposed to human cruelty and frailty. When the seventeen-year-old prefects who ruled the dormitories were caught torturing the younger boys, they didn’t stop the hazing. Instead, they invented “the jack bank”, where underclassman could save beatings safely dispensed when nobody was looking, earn interest on their deposits, and draw on them later to atone for their supposed infractions. Retief writes movingly of the complicated stew of emotions and politics that informed this punitive all-male world, and of how he navigated its shoals, sometimes identifying with his torturers himself even as he began to realize that his adult life and sexuality would be very different than theirs. The book ends with the exhilarating freedom of democracy and self-acceptance.
Read an excerpt of The Jack Bank.


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The WORLD'S STRONGEST MEN come to WALES!
After a thrilling 2021 tour, we’re going bigger and better in 2022 and bringing the Giants Live World’s Strongest Man Arena Tour to the Motorpoint Arena in the picturesque city of Cardiff! See the World’s Strongest Men perform scarcely believable feats of strength- from lifting massive weights, throwing huge barrels and even carrying cars- in front of your very eyes!
The 2021 Giants Live Open was won by American sensation Evan Singleton who will be giving his absolute everything to defend his title in Cardiff in 2022. He’ll face tough competition from World’s Strongest Man legends such as 2020 World Champion Oleksii Novikov and 2020 Britain’s Strongest Man Adam Bishop- both of whom were hot on Evan’s heels in 2021.
We are incredibly excited and privileged to be bringing the biggest and best Strongman Arena Tour on the planet to Wales in what is expected to be a sell-out event. See the World’s Strongest Men go head-to-head in 5 tests of strength, speed and raw power to claim the Giants Live Open title and along with it, a golden ticket to the World’s Strongest Man competition.
Jaw-dropping, inspirational and larger than life – this is live strength sport and entertainment at its absolute biggest and best! There is only one World’s Strongest Man Arena Tour and this is it!

domain: sports


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Gladys Ganiel is a Research Fellow in the Senator George J. Mitchell Institute for Global Peace, Security and Justice at Queen’s University Belfast. She is the author of Evangelicalism and Conflict in Northern Ireland and Transforming Post-Catholic Ireland.
Over at Democratic Audit, Ganiel writes about the role of evangelicals in bringing peace to Northern Ireland.
Here is a taste:
An organisation called Evangelical Contribution on Northern Ireland (ECONI) is perhaps Northern Ireland’s best example of how faith-based activists contributed to peace. ECONI was formed in the mid-1980s as a direct counter to ‘Paisleyism.’ In my own research, I spoke to people who said that the ideas they first heard through ECONI led to changes in their identity and a commitment to engage in peacebuilding. ECONI encouraged people to first be self-critical of their own religious tradition – and then to use resources from within that tradition to change it.
There’s an old slogan within the Protestant community, which could be said to reflect the ideal relationship between church and state within covenantal Calvinism: ‘For God and Ulster.’ ECONI’s first public act turned that slogan on its head. It was an open letter in the Belfast Telegraph titled ‘For God and His Glory Alone’. ‘For God and His Glory Alone’ was later distributed as a booklet, with five printings and more than 10,000 copies. More than one-third of all Protestant congregations in Northern Ireland participated in ECONI initiatives.
‘For God and His Glory Alone’ illustrates how ECONI was self-critical of the evangelical, Calvinist tradition. ECONI capitalised on evangelicalism’s high regard for the Bible by justifying its critique of Northern Irish versions of covenantal Calvinism through fresh interpretations of scripture.
ECONI also developed religious ideas that were relatively unique within Northern Irish evangelicalism. It was inspired by engagement with the Anabaptist tradition – including figures like John Howard Yoder and Stanley Hauerwas – and drew on the Anabaptist tradition to argue for a separation between Protestantism and Unionist political power, and to advocate pacifism or non-violence in almost all circumstances.
Finally, ECONI’s self-critical reflection on Northern Irish evangelicalism led to repentance – not asking the ‘Other’ to repent but rather confessing the ‘sins’ of its own community. This opened doors for relationships with people from Catholic backgrounds.
ECONI’s effectiveness rested in part on its credibility: ECONI’s evangelical identity provided it with a legitimacy that some ecumenical peacebuilding organisations lacked. It might be assumed that policy makers and secular peacebuilding NGOs should engage with moderate religious groups that are attempting to transcend sectarian identities – like ecumenists. Such a strategy would have excluded ECONI.
Read the rest here.

domain: sociology


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4to, pp. 24, including the original decorative paper wrappers, in full colour throughout, wire-sewn as issued, a few small marks, still very good, spine very lightly worn.
Added to your basket:
Мишкины соседи [Little Bear’s neighbours].
First edition. A very nice copy of this collection of verses for young children, composed by one of the most prolific Soviet children’s poets, and illustrated by one of the most prolific of Soviet children’s artists. The tales tell of the lives of a selection of farm and wild animals, including a calf, a foal, a fox, a wolf-cub and the little bear of the title.
Zinaida Aleksandrova was the author of around seventy poetical works for children, many of which were repeatedly republished, or turned into songs. Dmitry Gorlov was a celebrated Soviet sculptor, graphic artist and animal painter. He worked as an illustrator of children’s books from 1922 onwards, eventually going on to work as a ceramic designer from the famous Dmitrov factory in Gzhel.
Rare. OCLC finds only a single copy, at Chicago.
You may also be interested in...
MITCHISON, Naomi; Wyndham LEWIS, illustrator.
Beyond this Limit …
First edition. This was Lewis’s only collaboration with Mitchison but she arranged for the publication of his Left Wings over Europe the following year, and they remained friends until his death. 32 designs by Lewis served as the inspiration for Mitchison’s narrative.
[MONTAGU, Mary Wortley (attr.), and PUISSIEUX, Madeline de (translator).]
La femme n’est pas inferieure a l’homme, traduit de l’anglois.
First French translation, uncommon, of Woman not inferior to Man: or, a short and modest Vindication of the natural Right of the fair-Sex to a perfect Equality of Power, Dignity, and Esteem, with the Men, first published in 1739 under the name ‘Sophia, a person of quality’ and sometimes attributed to Mary Wortley Montagu (1689–1762; see Quaritch, Women (2019) 36). Drawing on De l’égalité des deux sexes of Poulain de la Barre, the work examines the justness of the esteem (or lack thereof) in which men hold women, the relative intellectual capacities of the two sexes, whether men are fitter to govern and hold public office than women, and whether women are capable of teaching the sciences and serving in the military. The author concludes: ‘let us show [men], by what little we do without aid of education, the much we might do if they did us justice; that we may force a blush from them, if possible, and compel them to confess their own baseness to us, and that the worst of us deserve much better treatment than the best of us receive’.

domain: artistic


President Barack Obama's heartfelt speech at the Newtown memorial service was more than just a touching tribute to 26 innocent victims: it was a subtle call to action for our nation's politicians, activists and citizens, alike. Though the word "gun" was never uttered, the message was clear: we've been failing our children and ourselves and we must now refuse to endure another tragedy.
Among the condolences to the victim's families, President Obama told the audience, "we are left with some hard questions." He asked if we can truly say that we're all doing enough to keep our children safe from harm and after reflecting, answered "no."
Then came the shift in tone which marked the president's strengthened resolve to fix our nation: "No," he said, "We're not doing enough. And we will have to change."
"We can't tolerate this anymore. These tragedies must end. And to end them, we must change."
President Obama has always been known for his brilliant rhetoric and now, that gift is being put to use. Never crossing the line between heartfelt memorial speech and political campaigning, the president still made his intent clear: "Surely, we can do better than this."
Amidst cries from Republican politicians that the absence of God in schools brought us what we deserve and that more guns are the answer, the president's speech painted a hopeful vision for a better future.
"In the coming weeks, I'll use whatever power this office holds to engage my fellow citizens, from law enforcement, to mental health professionals, to parents and educators, in an effort aimed at preventing more tragedies like this, because what choice do we have? We can't accept events like this as routine."
The president is right: we can't accept tragedies like this anymore. The first step is to get off the side lines and become activists ourselves, demanding the bright future our children deserve and not stopping until we get it. President Barack Obama's memorial speech was a brilliant move in beginning the national political conversation about how we can do better. Because, in fact, we can - and must - do better.
The speech ended with a softened tone but reinforced the message of change: "For those of us who remain, let us find the strength to carry on and make our country worth of their memory." As it stands, our country, where it's easier to obtain a gun than access mental health, isn't worthy of the victims' memory and it's up to us to make it so.


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A MAKING MUSIC LEARNING FUN
Wendy’s Programs are designed to make learning to read and play so simple that you can play a tune in your first session.
Tunes have easy to play backing tracks that make you sound like an instant rock star!
For those who enjoy variety, there are many choices of activities you can have fun with.
Get your groove on with CREATE playalongs,
Test your knowledge with fun flashcard games,
Play well known music at the level that you can achieve,
See your progress as you master lesson by lesson, level by level,
and much more!
Everyone has a voice and therefore everyone has the ability to sing, Singing well means having good breath control, keeping in tune, clear pronunciation of words and much more which is where singing lessons from an expert can help.
Vocal music surrounds us in a myriad of musical styles. There is Popular or contemporary music, classical and jazz, musical theatre and so many more styles. It is not necessary for students to select one style or another when they are starting.
A TYPICAL SINGING SESSION:
A typical singing session should start with some warmup exercises to avoid injury. Your lesson may then proceed to some technical exercises to work on your pitch, your range, tone or another aspect of your sound production.
Sight singing which involves learning to read traditional music notation is valuable to open the door to independent learning.
WHAT YOU NEED FOR LEARNING SINGING:
For Singing lessons you are lucky to be able to always have your instrument ( your voice) with you, and you don’t have to buy it! You do however have to look after it, so we suggest you always have a water bottle on hand to keep your voice hydrated.
During singing session you will have the use of Wendy’s learning resources as part of your lesson fees, but you may decide to purchase additional music.
Headphones and access to a digital library is handy and for many students access to a keyboard or piano to help keep in pitch for warmup exercises at the very least can be really useful!
OR Book a group trial lesson here:


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Professor Sherman received his bachelor’s and law degrees from Harvard University, where he served as a staff member of the Harvard Civil Rights-Civil Liberties Law Review. He spent three years with the St. Paul, Minnesota, firm of Doherty, Rumble & Butler and a year with the Office of the Tax Legislative Counsel in the United States Department of the Treasury, Washington, D.C. He was an assistant professor of law at the University of Illinois from 1976 to 1978. Professor Sherman joined the Chicago-Kent faculty as an associate professor in the fall of 1978. He was a visiting professor at Harvard in 1993 and 1995 and has also visited at UCLA in 1990, the University of Miami in 1987, the University of Illinois in 1983, and the University of Arizona in 1981. Professor Sherman has written extensively in the areas of wills, taxation and employee benefits, and is the author of Cases and Materials on Pension Planning and Deferred Compensation. Professor Sherman is a member of the American Law Institute. In 1989, he was named a Norman and Edna Freehling Scholar and an Arthur and Marjorie West Scholar. In 1991, he was elected an academic fellow of the American College of Trust and Estate Counsel.
Can Religious Influence Ever Be "Undue" Influence?, Brooklyn Law Review (2008)
Prenuptial Agreements: A New Reason to Revive an Old Rule, Cleveland State Law Review (2006)
I Say It's Spinach: Charitable Trusts to Remedy Market Failures in the Performing Arts, UMKC Law Review (2003)
Contributions to Books

domain: law


text:
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The α-hemolysin (αHL) is a self-assembling exotoxin that binds to the membrane of a susceptible host cell and causes its death. Experimental studies show that electrically neutral β-cyclodextrin (βCD) can insert into the αHL channel and significantly increase its anion selectivity. To understand how βCD can affect ion selectivity, molecular dynamics (MD) simulations potential of mean force (PMF) calculations are carried out for different αHL channels with and without βCD adapter. A multiscale approach based on the Generalized Solvent Boundary Potential (GSBP) is used to reduce the size of the simulated system. The PMF profiles reveal that βCD has no anion selectivity by itself, but can increase the Cl− selectivity of the αHL channel when lodged into the pore lumen. Analysis shows that βCD causes a partial desolvation of ions and affects the orientation of nearby charged residues. The ion selectivity appears to result from increased electrostatic interaction between the ion and the channel due to a reduction in dielectric shielding by the solvent. These observations suggest a reasonable explanation of the ion selectivity and provide important information for further ion channel modification.
α-Hemolysin (αHL) secreted by the bacterium Staphylococcus aureus is an exotoxin involved in a number of human diseases.1–3 It can self-assemble on lipid bilayers of a susceptible host cell membrane to form a wide heptameric pore.4 Uncontrolled permeation of water, ions and small organic molecules through this wide transmembrane pore can then lead to the death of the host cell.5 Being a particularly robust structure, αHL has many potential applications in biotechnology, such as single-molecule detection,6–10 single DNA sequencing,11 nanochemistry,12,13 nano-electro-osmotic transportation,14 and modulation of ion selectivity.15 Important aspects of αHL as a promising scaffold for synthetic ion channels are: 1) it can bind to various biological or synthetic lipid bilayers readily and spontaneously; 2) once bound to the membrane, it is stable over a wide range of pH and temperature; 3) it can be modulated in many ways to adjust ion selectivity. Experimental studies show that the wild type αHL displays a weak anionic selectivity and this selectivity can be increased by mutation of residues lining the lumen of the channel,16 and by noncovalent7,15–17 or covalent linkage18 of a cyclic polysaccharide (β-cyclodextrin) in the lumen of the pore. For example, the (M113N)7 mutant and (M113F)7 mutant αHL channels have been reported to be able to bind the β-cyclodextrin (βCD) noncovalently for 104 times longer than the wild-type αHL16,17 and become highly chloride ion selective.15 However, βCD is an electrically neutral molecule and the underlying mechanism for the high chloride selectivity is unclear. To facilitate the chemical ion channel design, it is essential to understand how βCD improves the anion selectivity of the channel. Because ion selectivity is often dominated by relative free energy differences, molecular dynamics potential of mean force (PMF) calculation is a powerful approach to deepen our understanding of the ion selectivity mechanisms at the atomic level. Here, molecular dynamics (MD) free energy simulations are carried out for different αHL channels with and without βCD adapted inside. To reduce the size of the simulated system, a multiscale approach based on the Generalized Solvent Boundary Potential (GSBP) is used whereby the local system is simulated with atomic detail and the effects of the surroundings are approximated with continuum electrostatics.19
The outline of the article is as follows. In the following section, the theoretical background, the system preparation and details about the simulation are briefly described. Then, the interactions of isolated βCD with ions are calculated, first in vacuum and then in explicit water solvent. The free energy of ion passage through the βCD adapted channel (M113N)7·βCD and (M113F)7·βCD is investigated and compared with the free energy in the isolated channels and wild-type channel. Finally, the main results are summarized in the last section.
The CHARMM PARAM2720 force field was used for the protein and the TIP3P was used for the water molecules.21 The generalized AMBER force field (GAFF)22 was used to model βCD. The topology and parameters of βCD for CHARMM were generated with ANTECHAMBER 1.2723 and with AM1-BCC24 partial charges (provided in Supplementary Material: Table S1 and S2). The electrostatic potential surface of βCD (Figure 3) was produced using Molecular Operating Environment, version 2007.09 (Chemical Computing Group, Montreal), and AM1-BCC partial atomic charges.24 A Gaussian surface was generated, and potential was calculated using the Poisson-Boltzmann (PB) equation.25 The parameters for K+ and Cl− were taken from reference 26. Five channel systems were generated using CHARMM27,28 on the basis of available X-ray structures. They are: wild-type αHL,29 (M113N)7, (M113F)7, (M113N)7·βCD and (M113F)7·βCD (Montoya and Gouaux, unpublished). However, there are one side chain missing in (M113F)7 crystal structrue (Lys110→Gly110) and two side chains missing in (M113N)7 crystal structure (Tyr148→Ala148, Leu1288→Gly1288). We modified the (M113F)7 structure by adding back the charged Lys110, while keeping the (M113N)7 crystal structure unchanged. Hydrogen atoms were added using the HBUILD facility in CHARMM. The protonation state of the channels was chosen as in Noskov et al.30 In the simulations the channel structures are oriented with their pore along the z-axis. The negative z-axis corresponds to the intracellular side (trans side) and the positive z-axis corresponds to the extracellular side (cis side). The center of the implicit membrane is located at z = 0 Å, extending in the x and y directions with a thickness of 25 Å (Figure 1). In the X-ray structures, the seven glucose 6-OH groups of βCD point toward the trans side in the (M113N)7·βCD channel, but toward the cis side in the (M113F)7·βCD channel. The center of mass of βCD is located approximately on the z-axis around 25 Å in the (M113N)7·βCD system and at 26 Å in the (M113F)7·βCD system.
The GSBP method implemented into the PBEQ module31–33 of the CHARMM program, was used to simulate a reduced atomic model of αHL. The multiscale approach based on the GSBP is similar to the semi-microscopic approach in existing literatures.34–37 The theoretical foundation about GSBP method can be found in 19. In our simulation, a spherical inner region was centered at (0.0, 0.0, 30.0), with a radius of 20 Å. The inner region was extended by 3 Å to define a smooth spherical dielectric cavity of 23 Å. Protein atoms near the edge of the boundary were fixed during the simulation. In the inner region (see Figure 1 for top view and side view), the protein, the cyclodextrin, and the solvent molecules were simulated explicitly with all-atom MD simulations. In the outer region, the remaining protein atoms and solvent were treated implicitly. The influence of the surrounding outer region on the atoms of the inner region is represented in terms of a solvent-shielded static field sf and a solvent-induced reaction field rf. The reaction field due to changes in charge distribution in the dynamic inner region is expressed in terms of a basis set expansion of the inner region charge density. The solvent-shielded static field from the outer region and the reaction field matrix , representing the couplings between the generalized multipoles were calculated once and recalled during the later simulations. Dielectric constants were assigned values of 80 for solvent, and 2 for both protein and membrane. The finite-difference PB calculation was solved with periodic boundary conditions in the xy-plane. The KCl concentration was assumed to be 150 mM in the bulk solvent. The reaction field matrix and static field were calculated using a 1113 coarse grid with a grid spacing of 3.0 Å, followed by a 1613 fine grid centered at the center of mass of βCD with a grid spacing of 0.5 Å. The reaction field matrix was built using 25 basis functions of 5 multipoles without sorting. After defining the inner region and calculating the static field and reaction field matrix, the inner region system was hydrated with explicit TIP3P water molecules. We used 20 cycles of 10000 steps of MC followed by 10000 steps of Langevin dynamics. The MC consists of rigid body translation, rotation and GCMC (grand canonical Monte Carlo) moves with equal probability. A friction coefficient of 5 ps−1 was assigned to all nonhydrogen atoms for the Langevin dynamics.
The 1D-PMF W (z) was calculated using umbrella sampling,38 in which a set of equally spaced simulations were biased by the quadratic potential wi(z) = (1/2)ki(z-zi)2 to restrain the ion near specific positions zi along the z-axis; 61 independent windows, separated by 0.5 Å increments in the z direction from 15 Å to 45 Å, were simulated with Langevin dynamics. A force constant of 5 kcal/mol/Å2 was used for the harmonic potential to ensure overlap of neighboring windows. A time step of 2 fs was used for all simulations and a friction constant of 5 ps−1 was applied to all nonhydrogen atoms. Each window simulation started from the configuration equilibrated during 20 ps with the ion near the constraint position. 500 ps of trajectory was generated for each window. The results were unbiased using the weighted histogram analysis method (WHAM),39 with a bin size of 0.05 Å and a stringent tolerance of 0.0001 kcal/mol on every point in the PMF.
For calculating the PMF of one ion passage through βCD in explicit solvent, the βCD is located in the center of a cylinder of TIP3P water molecules. The cylinder of solvent contains 404 TIP3P molecules and is about 62 Å in length and 7.6 Å in radius. Periodic boundary conditions were used for the cylinder system (tetragonal box 31×31×62 Å3 with cutoff distance 15 Å). The parameters for umbrella sampling are the same as in the channel system described above.
Continuum electrostatic calculations were carried out by moving one ion along the z-axis by 1.0 Å increments through the whole channel. The aqueous solution (including the water-filled cavity at the center of the channel) was represented as a uniform continuum media with a dielectric constant of 80. The channel with all explicit atoms was embedded into a low dielectric planar slab simulating the membrane, represented as a uniform slab of 25 Å thickness with a dielectric constant of 2.40 The crystal structures were used. The dielectric constant of the protein interior was assumed to be 2. All calculations were performed using the PBEQ module,31–33 implemented in CHARMM.27,28 The atomic charges were taken from the all-atom PARAM27 force field of the CHARMM program and the atomic radii used to define the protein-solvent dielectric boundary were taken from previous free energy simulation studies with explicit water molecules.31 Each PB calculation was performed in two steps with a cubic grid of 2403 points, starting with a grid spacing of 1.0 Å, followed by a focusing around the main region with a grid spacing of 0.5 Å.
The position-dependent diffusion coefficient of K+ and Cl− inside the βCD were calculated from the umbrella sampling MD trajectories using the GSBP reduced (M113N)7·βCD system. The details about the simulations are the same as described in the PMF calculations, except that the Langevin dynamics was turned off within a radius of 12 Å from the center by setting the parameter RBUF=12. The theoretical formulation used here was previously elaborated by Hummer,41 based on an early development by Woolf and Roux.42 Briefly, the position-dependent diffusion coefficient D(z) along the z-axis aligne with the pore is expressed as,
where z(t) is the position of the ion along the z axis, δz(t) = z(t) − z (i), and τi is the correlation time extracted from the biased simulation with the ith window potential,
The diffusion coefficients in bulk are computed from additional MD simulations in which a K+ or Cl− was placed in a droplet of about 600 explicit TIP3P water molecules, contained by the reactive spherical solvent boundary potential (SSBP).26 The ion was restrained near the center of the droplet by a harmonic potential. The diffusion coefficients in bulk calculated using the same equations (1, 2) are 0.33 Å2/ps for both K+ and Cl−, which is in agreement with a previous MD study.43
Figure 3 shows the electrostatic potential surface of βCD calculated in vacuum. The potential is slightly more positive through the lumen of the cyclodextrin (blue and red surfaces indicate a positive and negative potential, respective). The ion selectivity of βCD alone was first examined by moving one ion through βCD in vacuum. The results are shown in Figure 4A. The vacuum inter-actionn energy profiles of K+ and Cl− has symmetric and opposite interactions, mainly due to the charge distribution of the βCD. In vacuum, the passage of Cl− is opposed by a larger energy barrier than K+. As shown in Figure 4B and D, the large energy barriers observed in vacuum are considerably reduced by the influence of solvation. In Figure 4B, the electrostatic free energy of a single ion passing through βCD was calculated using continuum electrostatics Poisson-Boltzmann (PB). In Figure 4D, the corresponding free energy profiles were calculated using umbrella sampling MD simulations with explicit solvent molecules. The latter reveal relatively complex interactions, due in part to solvation and desolvation effects of the ions as they pass through the small aperture of βCD. Nevertheless, while there are quantitative differences, both Figure 4B and D show that β CD, by itself, is not selective for Cl− over K+ when solvation effects are taken into account.
The influence of the βCD and the pore architecture on the ion transfer is investigated for five αHL channel systems: wt-αHL, (M113N)7, (M113F)7, (M113N)7·βCD and (M113F)7·βCD. For each system, the PB calculations and the PMF calculations were carried out as described in Method section. The channel pore radius of the crystal structures versus position along the channel axis (Figure 2) shows that there are two constriction regions inside the channels. The first one is at the top of the β-barrel (near z = 30 – 35 Å), with the total charge of +7e (7 Glu and 14 Lys residues). The second constriction region is at the transmembrane domain (near z = 0 Å), with the total charge of −7e (7 Lys and 14 Asp residues). The free energy in the PB calculations is dominated by these two regions. Figure 5 shows the electrostatic free energy profiles obtained from PB calculations by moving one ion along the z-axis through the five channels. These profiles show that the free energy minima for Cl− (solid lines) and maxima for K+ (dashed lines) are located between z ~ 30 to 35 Å. In the transmembrane region (z between −12 and 12 Å), the free energy of Cl− goes up and that of K+ goes down. These electrostatic free energy profiles correspond to the common feature of the αHL structure.
The structural difference among three channels, wt-αHL, (M113N)7, (M113F)7, is only at residue 113, which is located near z = 29 Å. The large change in the electrostatic free energy profiles with the neutral mutation is actually caused by different orientation of Asp128 and Lys131 side chains at the bottom of the crystal structures. This can be confirmed by re-constructing the (M113N)7 and (M113F)7 mutants from the wt-αHL X-ray structure, while keeping the configura-tion of the other side chains unchanged. The PB calculations on these model structures, shown in Figure 6, confirm that the residue 113 does not give rise long range effect in the transmembrane region. Comparing the energy profiles in the βCD adapted channels (red lines) with the isolated channel (black lines), Figure 5b and c both show that the electrostatic free energy barrier between Cl− and K+ is higher in the βCD adapted channels than in the isolated channel.
Figure 7 shows the PMF of Cl− (red line) and K+ (blue line) in the GSBP inner region of the five channels. The PMF profiles of the isolated channels (Figure 7a, b, and c) are relatively smooth and symmetric, similar to the electrostatic free energy obtained from PB calculations (dashed lines). These profiles suggest that the ion selectivity in the isolated channels is dominated by electrostatic interaction between the ion and the channel. The largest free energy difference between Cl− PMF and K+ PMF are found near z ~ 35 Å in wt-αHL and the (M113F)7 (Figure 7a and c), and near z ~ 31 Å in the (M113N)7 mutant (Figure 7b). Those positions correspond to the narrowest region in each channel, where seven Lys147 residues are located (see the pore radius profile Figure 2). The position of the narrowest region in the (M113N)7 is lower along the z-axis than the other channels because of the different orientations of Lys147 residues. The snapshots of partial X-ray structures in Figure 8 show that Lys147 residues are pointing upwards in both wild-type and the (M113F)7, while they are pointing slightly downwards in the (M113N)7. The Lys147 has a considerable impact on the PMF because the 7 positively charged side chains form a narrow ring, giving rise to a very strong electrostatic field in this region of the pore.
Figure 7d and e show the PMF of Cl− and K+ in βCD adapted channels. These PMF profiles are clearly distinct from the one without βCD (Figure 7b and c). The Cl− PMF in (M113N)7·βCD channel features three distinct areas (Figure 7d). As illustrated in the inserted snapshots, the PMF in unfavorable when Cl− goes through the βCD. The local energy barrier, similar to Figure 4D, reaches a maximum at z ~ 26 Å, near the center of the βCD. Then, the free energy goes down and reaches a minimum when the Cl− exits the βCD cavity. The K+ PMF remains unfavorable, displaying no region of appreciable stabilization in the inner region. Similar features are also found in (M113F)7·βCD profiles (Figure 7e).
The PMF profiles show that the βCD can change the free energy of Cl− and K+ near the adapter region. Further analysis was performed to elucidate the role of the βCD in the lumen of the pore. First, βCD causes the partial desolvation of both ions. Taking the (M113N)7·βCD system as example, the average number of water molecules in the first solvation shell of Cl− (red lines) and K+ (black lines) are shown in Figure 9. The first solvation shell radii are 3.7 Å for Cl− and 3.5 Å for K+, based on the radial distribution function (RDF) curves (not shown here). Comparing the water profile in (M113N)7·βCD (solid lines) with the one in the isolated channel (dashed lines), about two water molecules are removed when Cl− or K+ approaches the small rim of βCD (position a in Figure 9). When the ions are near this position, the primary hydroxyl groups on βCD are able to rotate freely and interact with both Cl− or K+. The snapshots in Figure 9 a show typical configurations of ions with their hydration shell near this position (Cl− in green, K+ in yellow). After entering the βCD cavity, both ions stay in the center of the cavity and no special interaction is observed (snapshots b). Hence the first solvation shell is partially restored in the βCD cavity (position b in Figure 9). When the ions exit the βCD and approach the Lys147 ring, there is a strong electrostatic interaction between the ions and positive amino groups of Lys147 (snapshots c). However, the first solvation shell of K+ remains intact, while the Cl− loses one water molecule, as shown in the water profile (position c in Figure 9). This can be explained by the strong electrostatic interaction between Cl− and Lys147, which disrupt the hydration shell of the anion. The presence of βCD also affects the orientation of the side chain of Lys147. The angle distributions of Lys147 side chain (Supplementary Material, Figure S1) suggests that βCD can restrict the rotation of Lys147 by forming hydrogen bonds between hydroxyl group on βCD and Lys147 side chain in (M113N)7 mutant. The (M113F)7·βCD profile (Figure S1 d) also suggests that the partial desolvation of Cl− caused by βCD increases the electrostatic interaction between Cl− and the positively charged Lys147 residues.
At this point, our analysis has been exclusively focused on structural and energetic factors associated with ion movement. However, permeation can also be affected by purely dissipative factors, such as the friction or mobility coefficient along the pore.44 For instance, the position-dependent diffusion coefficient of ions is a central input parameter in many theoretical descriptions of permeation.43,45–47 To determine whether this plays an important role on the anionic selectivity induced by βCD, the diffusion coefficients of K+ and Cl− along the pore axis were calculated using biased simulations. The umbrella sampling MD trajectories of (M113N)7·βCD were used. The diffusion coefficient profiles of K+ and Cl− as a fraction to bulk values along the channel axis (15 < z < 35) shown in Supplementary Material (Figure S2). The bulk value is 0.33 Å2/ps for both K+ and Cl−as observed in previous studies of OmpF.43,47 The average fraction of bulk diffusion coefficient inside the βCD (21 < z < 29) is about 0.115 for both K+ and Cl−. There is a reduction by about a factor of 10 in the narrowest part of the pore relative to the bulk. In a continuation of the present study,48 the information about the position-dependent diffusion coefficients of K+ and Cl− calculated here from all-atom MD simulation with explicit solvent will be incorporated into Brownian Dynamics (BD) simulations and generate multi-ion GCMC/BD simulations.45 The present results will be important to calibrate the BD simulations, particularly within the narrowest region in the pore through the βCD.
We have performed PMF calculations for five different αHL channels to elucidate the ability of a βCD adapter to increase the anion selectivity of these channels. The free energy profiles suggest that βCD alone has no intrinsic Cl− selectivity over K+ ion, but it can increase the Cl− selectivity of the αHL mutants when lodged inside the lumen of the pore. A detailed trajectory analysis shows that the βCD causes a partial desolvation of the ions and also affect the orientation of nearby charged residues. The ion selectivity appears to be improved when the ion is less shielded by the solvent, which increase the electrostatic interaction between the ion and the channel. These observations suggest a reasonable explanation of the ion selectivity and provide important information for further channel modification. For example, the cyclodextrin can be modified by adding positively charged groups to increase anion selectivity or by adding bulky groups to increase the desolvation effect. The modified cyclodextrins can be inserted into the channel and their effect on ion selectivity can be rapidly evaluated by the computational inexpensive single ion PMF calculation. A large number of known channelopathies require multiple channel modifications to adjust ion selectivity. For example, cystic fibrosis is caused by a defect in a gene coding for an anion channel.3 The present study shows that computational simulations provide an efficient way to predict the ion selectivity, and could further support the experimental exploration of artificial exploration of artificial ion channel design.
One important aspect missing from the present study is the influence of multiple ions inside the pore. The anion selectivity displayed by the single ion PMFs with and without βCD seems overestimated. In a wide channel like αHL, multi-ion screening is expected to impact on the electrostatic interactions between the pore and the ions. One can expect that the multi-ion PMF will be less dominated by the electrostatic interaction, therefore becoming more sensitive to the geometry of the pore. This part is discussed in the follow-up study.48
We are very grateful to Eric Gouaux and Michelle Montoya for making available to us the coordinates of the αHL mutants with and without βCD adapted X-ray structures prior to publication. Helpful discussion with Hagan Bayley, Haichen Wu, Haibo Yu, Ed Harder, Xiaoxia Ge, Yuhui Li, Devleena Shivakumar, and Yuqing Deng are gratefully acknowledged. This work was supported by the National Institutes of Health (NIH) through the NIH Roadmap for Medical Research (award number PHS 2 PN2 EY016570B).

domain: chemistry


House Minority Leader Nancy Pelosi’s choice for a powerful committee position was defeated by the Democratic conference on Wednesday, a rare intra-party setback for the Californian.
Rep. Frank Pallone (D-NJ) won in a 100-90 caucus vote to be ranking member of the Energy & Commerce Committee, according to two Democrats in the room.
He defeated Rep. Anna Eshoo (D-CA), a close Pelosi ally who won the steering committee vote for the position by a 30-19 margin one day earlier.
Pallone was next in line for the position, with Rep. Henry Waxman (D-CA) retiring in January. But Pelosi had been pushing for months to help Eshoo leapfrog the New Jersey Democrat. On November 10, she wrote a “Dear Colleague” letter endorsing Eshoo and urging Democrats to back her for the job.


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LENOVO M910Q USB DRIVER (lenovo_m910q_2272.zip)
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The Lenovo ThinkCentre M700 10GT002SUS is a small-form-factor business desktop made for homes, offices and the casual user s desks. But that option is mentioned in the PDF spec and on the product page. When you connect a high-current storage drive to only one USB connector, the system might not recognize the device. Our typical workstation purpose-built for enterprises.
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Hi!congratulation Kim Nan Gil,I like you so much because of your smile,excellent actions and talent. Your are also very intelligent,brave,hard working and skilful actor.I live in Sydney and I watched your series "Queen Seon Deok" in this 2011 new year .I watched 3 Korean series including your movies in my life.I think Queen Seon Deok is best. I have language barrier because I am Burmese. I didn't understand many words when I watch this movies. I read Chinese and look your action. Although I have poor Chinese I can feel your action. In deed it is very hard to watch because of language problem. Whenever I watch Korea series I cry a lot becaus all are sad love movies. While I watch your movie I cry alot. After finish movie I am still cannot concentrate to work,sleep and eat.I will never forget you and your movie. I am very happy because you acheived many awards. I believe you will acheive more and more awards in future.Good Luck Bidam!.I wish you have a healty and happy love in your real life.
I really like Kim Nam Gil. I do not even know if he can find time to read this message. All I know is that even if there is a language barrier between us, I still like him! My dream is to meet him someday. I just don't know if this gonna be happen...hayyy...
Kim Nam-gil (Hangul: 김남길) (born 13 March 1981), is a South Korean actor. He used to go by the name Lee Han and later decided to use his real name since the movie Public Enemy Returns in 2008. He was honoured with a few awards for his excellent acting as Bidam in MBC TV Series Queen Seon Deok in 2009. He has enlisted in the army in 2010 after SBS TV Series Bad Boy. He was admitted to the army camp in Nonsan on July 15 for 4 weeks of basic military training and will serve as a public service worker at Gangnam-gu office according to the selective service system.
* 2010 46th PaekSang Arts Awards - Best New Actor in the field of TV.
* 2009 17th Korean Culture, Entertainment Award in the field of movie - Best New Actor.
* 2009 Style icon Award - TV Award.
* 2009 MBC Drama Awards - Male Excellence Award
* 2009 MBC Drama Awards - Best Couple Award (with Lee Yo Won in Queen Seon Deok)
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June 2001 by Staff• Vista Gold Corp
• Pan American Silver Corp
• Mountain Province Mining
China is an enormous country, behind only Russia, the United States (incl. Alaska), and Canada in size. It has a teeming population of 1.3 billion, far ahead of any other nation. Most of the population is jammed into the eastern half of China, with the western half being only sparsely inhabited. There are 5 western provinces...
I had been looking forward to this trip since last year when the annual trip had rewarded me with a ¾-pennyweight nugget.
California Wilderness Coalition and The Nature Conservancy Recruit Government Employees to Carry Out Huge Land Grab
US Geological Survey, US Forest Service, Bureau of Land Management, and California State Employees Attend Environmental Extremist Conference.
The loss of exploration monies that provide jobs and eventually lead to new mines may well cost the state far more in the long run than the new fees will raise.
So you think you know a lot about placer mining? Well let me tell you about a placer miner that has forgotten more about placer mining than you and I will ever learn in our lifetimes.
Throughout the years, there have been many arguments upon which a huge bull market in gold has been based. These include the rapid escalation of inflation, a destabilizing world in terms of war or international conflict or...
The Bawl Mill • Our Readers Say • San Diego County Tourmaline • Nebraska Couple Finds Big Nugget in Arizona • Great Basin Gold • GATA Update • Picks & Pans: Selecting a Gold Dredge • VLF Detectors and the Effect of Mineralization While Nuggetshooting • Search for the Legendary Sierra Azul • Public Lands for the People Educates Prospectors • Harshaw's Silver Days • Mining Stock Quotes and Mineral & Metal Prices • Melman on Gold & Silver • Crandon Mine Decision Still Years Away, Says State • Investors Hope to Revive Idaho Gold Mine


Boom! Break drops his fifth studio album and suddenly everything in the world seems that little bit brighter and funkier. Some tracks you might already know - 'Gunshot Love', 'Code Red' and 'Wait For You' have all been tried and tested bangers this year already - but the rest is an odyssey waiting for you to explore. Featuring the likes of Liam Bailey, SP:MC, Lorna King, Charli Brix and the sadly departed Singing Fats (RIP), 'Digital World' runs the full Break gamut from graceful soul ('Lost') to utterly gully ('Another Life') and all funky shades and styles in between. Guaranteed vibes.
What is Album Only?
Some artists and labels prefer certain tracks to be purchased as part of an entire release. These tracks cannot be purchased individually but are available to download as part of the release


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Airport Check-in: Nashville opens military airport lounge
From USA TODAY's Airport Check-in column:
Nashville International Airport inaugurated its new military lounge last week. The lounge, on the ground transportation level, provides a place for military personnel to relax while traveling through Nashville.
"We hope the new military lounge will enhance the Nashville airport experience for members of the U.S. armed forces and their families," says airport spokeswoman Emily Richard.
Earlier this month, Nashville kicked off the second phase of its terminal renovation project.
When completed in 2010, the terminal will have a larger ticket lobby, a renovated baggage claim area and expanded restroom facilities, among other improvements.


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There are many vegetarian substitutes for steak, varying from tofu, and portobello mushrooms to jackfruit.
If you are catering for a vegetarian, or you embarking on a new diet, this guide will show you there are many delicious vegetarian substitutes for steak that you can eat instead.
In This Article
Why Choose Vegetarian Substitutes for Steak?
If you’re looking for a healthier and more sustainable alternative to steak, vegetarian substitutes are a great option to consider. Not only are they better for the environment, but they can also provide numerous health benefits.
One of the main reasons people choose vegetarian substitutes for steak is because they are typically lower in fat and calories. This can be beneficial if you’re trying to lose weight or maintain a healthy weight. Additionally, many vegetarian substitutes are high in fiber, which can help you feel fuller for longer periods of time.
Another benefit of vegetarian substitutes is that they are often rich in nutrients such as vitamins, minerals, and protein. For example, seitan, which is made from wheat gluten, is a popular meat substitute that is high in protein and can be used in a variety of dishes. Other vegetarian substitutes such as tofu, tempeh, and legumes are also great sources of protein and can be used in a variety of recipes.
Choosing vegetarian substitutes over steak can also be beneficial for those following a vegetarian or vegan diet. By eliminating meat from your diet, you can reduce your risk of certain health conditions such as heart disease, high blood pressure, and certain types of cancer.
Finally, choosing vegetarian substitutes can also be a more sustainable option. The meat industry is a major contributor to greenhouse gas emissions and deforestation, so by choosing vegetarian substitutes, you can help reduce your carbon footprint and support more sustainable farming practices.
Best Vegetarian Substitutes For Steak
Tofu is a popular vegetarian substitute for steak because it is high in protein and has a meaty texture. You can marinate tofu in a variety of flavors to enhance its taste, such as soy sauce, garlic, and ginger. Firm tofu is best for grilling or frying, while softer tofu is better for stir-frying or adding to soups.
Mushrooms are another excellent substitute for steak because they have a meaty texture and a rich umami flavor. Portobello mushrooms are particularly popular because of their large size and meaty texture. You can grill or sauté mushrooms with garlic and herbs for added flavor.
Beans are a great source of protein and can be used as a substitute for steak in dishes such as chili or tacos. Black beans, kidney beans, and chickpeas are all popular options. You can also make bean burgers or meatballs by combining mashed beans with breadcrumbs and spices.
Seitan is a protein-rich meat substitute made from wheat gluten. It has a chewy texture and can be flavored with a variety of spices and sauces. Seitan is often used as a substitute for beef or chicken in stir-fries, stews, and sandwiches.
Tempeh is a fermented soybean product that has a nutty flavor and a firm texture. It is high in protein and can be sliced or crumbled to use as a substitute for steak in dishes such as stir-fries, sandwiches, and salads. Tempeh can be marinated or seasoned with spices and sauces for added flavor.
Jackfruit is a tropical fruit that has a fibrous texture similar to pulled pork. It is often used as a vegan substitute for barbecue or pulled pork sandwiches. Jackfruit can be seasoned with barbecue sauce or other spices to enhance its flavor.
How To Cook Vegetarian Substitutes For Steak
If you’re a vegetarian, you don’t have to miss out on the delicious taste of steak. There are plenty of vegetarian substitutes available that can be cooked to perfection just like a regular steak. Here are some tips for cooking vegetarian substitutes for steak:
Grilling is one of the best ways to cook a vegetarian steak substitute. You can grill vegetables such as mushrooms, onion, and bell pepper, or you can use a pre-made vegetarian steak substitute. If you’re using a pre-made substitute, make sure to brush it with oil and season it with salt and pepper before grilling. Cook the steak substitute over high heat for a few minutes on each side, until it’s charred and cooked to your liking.
Sauces and Marinades
Sauces and marinades can add extra flavor to your vegetarian steak substitute. Try marinating your substitute in a mixture of olive oil, balsamic vinegar, garlic, and oregano for a few hours before grilling. You can also make a simple sauce by mixing together soy sauce, honey, and ginger. Brush the sauce over the substitute while it’s grilling to add extra flavor.
Seasonings and Spices
Seasonings and spices can make a big difference in the flavor of your vegetarian steak substitute. Try seasoning it with salt, pepper, and garlic powder before grilling. You can also add some smoked paprika or cumin for a smoky flavor. If you’re using a pre-made substitute, check the label to see what seasonings and spices are already included.
Overall, there are many ways to cook vegetarian substitutes for steak. Whether you’re grilling, using sauces and marinades, or experimenting with different seasonings and spices, you can create a delicious and satisfying meal without sacrificing flavor or texture.
Recipes Using Vegetarian Substitutes For Steak
Vegetarian Steak Sandwich
If you’re looking for a hearty meal, try a vegetarian steak sandwich. Use vegetarian steak slices or patties, and add your favorite toppings such as lettuce, tomatoes, and onions. You can also add a sauce of your choice, such as a creamy garlic sauce or a spicy barbecue sauce. Serve it on a toasted bun or bread of your choice.
Vegetarian Steak Tacos
For a Mexican-inspired dish, try vegetarian steak tacos. Use vegetarian steak strips or crumbles, and add your favorite taco toppings such as shredded lettuce, diced tomatoes, and shredded cheese. You can also add a sauce of your choice, such as a salsa or a chipotle sauce. Serve it on a soft or hard taco shell.
Vegetarian Steak Salad
For a lighter meal, try a vegetarian steak salad. Use vegetarian steak strips or crumbles, and add your favorite salad toppings such as mixed greens, cherry tomatoes, and sliced cucumbers. You can also add a dressing of your choice, such as a balsamic vinaigrette or a creamy ranch dressing.
Vegetarian Steak Chili
For a warm and comforting meal, try a vegetarian steak chili. Use vegetarian steak crumbles or chunks, and add your favorite chili ingredients such as diced tomatoes, kidney beans, and chili powder. You can also add your favorite toppings such as shredded cheese and sour cream.
Vegetarian Steak Pasta
For an Italian-inspired dish, try a vegetarian steak pasta. Use vegetarian steak strips or crumbles, and add your favorite pasta ingredients such as diced tomatoes, garlic, and Italian seasoning. You can also add a sauce of your choice, such as a tomato sauce or a creamy Alfredo sauce. Serve it over your favorite pasta. When using vegetarian substitutes for steak, there are many options available such as eggplant, portobello mushrooms, and soy-based products. Experiment with different seasonings and spices to achieve the desired taste. Whether you’re gluten-free or looking for a meatless alternative, there are many options available to satisfy your cravings.

domain: food


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“You can leave it all behind and sail to Lahaina
just like the missionaries did, so many years ago
They even brought a neon sign: “Jesus is coming”
Brought the white man’s burden down
Brought the white man’s reign” – The Eagles “The Last Resort”
The Eagles’ “Hotel California” album closed with the epic track, “The Last Resort,” which vividly evoked the colonialist destruction of native cultures, and referenced Lahaina’s “Jesus Coming Soon” sign.
A new book, “Tourism Impacts West Maui,” peaks behind the facade of the tourist image of Lahaina and West Maui. “It upends all the ‘official’” stories about Lahaina and the rest of the Westside, shakes them until all the tourist marketing nonsense shatters, then gives a straight telling of what really happened,” noted a Maui Time review.
Edited by Lance Collins and Bianca Isaki, it features a collection of nine academic essays. It includes Sydney Iaukea’s essay on “heritage tourism” in Lahaina. Iaukea, who holds a doctorate in political science, worked in the service industry in Ka`anapali in her youth (she was also named the first “Miss Lahaina” in 1992). Maui Time notes: “Her essay, “The Re-Storing of Lahaina,” uses meticulous research to strip away the tourist-marketing that so clogs the town today.”
“Lahaina was built and preserved to mimic a whaling town so that tourists vacationing at the newly built Ka`anapali Beach Resort could visit after long days of rest and relaxation,” she writes. “However, the whaling tale that was recreated had very little in common with the actual industry that existed a century and a half prior. As this whaling historical record was foregrounded, all other social narratives of Lahaina took a backseat, with the missionary influence vying for a close second.”
Lahaina, as Iaukea notes, was only really a whaling town between the years 1842 and 1860. What’s more, none of the buildings on Front Street were specific to the whaling industry.
Lahaina was a plantation town, built literally on the bones of the old Hawaiian Kingdom’s capital – Moku`ula, which featured a small island constructed in the middle of fresh water ponds, fed by streams running down from the West Maui Mountains.
“This rich natural environment existed for centuries before the Pioneer Mill Company installed vast irrigation systems in West Maui that diverted most of the fresh water across the plains to the drier areas for sugar cane production,” Iaukea writes. “These massive water diversion projects produced stagnant waters, which are said to have introduced mosquitoes in Lahaina.” After using Moku`ula for “dumping grounds,” Iaukea writes, the Pioneer Mill covered it with a baseball field, which remains there to this day.
The freshwater pond known as Mokuhinia contained a one-acre sandbar island called Moku‘ula, which was home to the high chiefs of Pi‘ilani since the 16th century and a royal residence for the Kamehameha line in the 19th century. Mokuʻula was the private residence of King Kamehameha III from 1837 to 1845, when Lahaina served as the kingdom’s capital, and the burial site of several Hawaiian royals. The 1-acre island is considered sacred to many Hawaiians.
The pond was reported to be the home of Kihawahine, a powerful moʻo or lizard goddess. According to myth, the moʻo was a reincarnation of Pi’ilani’s daughter, the chiefess Kalaʻaiheana.
The Maui News reported how the history of Kauikeaouli, who made Moku’ula his private residential complex and became King Kamehameha III, awaits to be unearthed as well. It was buried more than 100 years ago by missionaries whose written accounts were colored by their disdain for him, said anthropologist and ethnohistorian Paul Christiaan Klieger.
Kauikeaouli was a “traditionalist”; he resisted the missionaries’ and his converted Christian regent Ka’ahumanu’s attempts to displace Hawaiian culture with Western ways, Klieger said. “He was kind of an outcast with the missionary establishment. That’s one of the reasons we don’t know too much about him.” Missionary writings about Kauikeaouli amount to “gossiping about him” and “criticizing him for not being a good Christian” or “for doing things traditionally Hawaiian,” he said.
Moku’ula represents a part of Lahaina’s Native Hawaiian history that was obliterated by the whaling and plantation eras, he said. Klieger is the author of “Moku’ula: Maui’s Sacred Island.”
Klieger’s book says that “compared to the dry, dusty streets of Honolulu, the peaceful, verdant gardens of Lahaina proved a stunning contrast.” “The thick shade of the breadfruit trees, which surrounded (their hosts’) cottages – the rustling of the breeze through the bananas and sugar cane – the murmurs of the mountain streams encircling the yard – and the coolness and verdure of ever spot around us – seemed . . . like the delights of Eden.”
Kamehameha III’s reign saw the rising power of missionaries who came to the islands to spread religion and to provide education. Eventually, they established businesses and took ownership of large tracts of land. “It had the effect really of destroying the Hawaiian kingdom and the Hawaiian culture,” he said.
After she converted to Christianity, Queen Ka`ahumanu, who has a shopping mall in Kahului named after, issued an edict in 1830 banning public hula performances. “The hula is forbidden, the chant (olioli), the song of pleasure (mele), foul speech, and bathing by women in public places,” historian Samuel Kamakau reported. Although it was apparently never formally rescinded, the law was so widely ignored, especially after Kaʻahumanu died in 1832, that it virtually ceased to exist.
The missionaries discouraged many Hawaiian cultural practices, and encouraged the spread of English.
When the Kamehameha School for Boys was opened on Oahu, Hawaiian language was forbidden in the classroom and on the playing fields, and boys were punished if they were heard speaking the language of their families. Hawaiian was officially outlawed at Hawaii’s public and private schools in 1896.
Missionary Rev. Sereno Bishop, who once lived in Hana, and gave prayers at the opening of the boys’ school, was vehemently anti-hula. The dance, he wrote, was “one of the foul florescenses” on the “great poison tree of idolatry.” Bishop said hula corroded Hawaiians—and labeled it moral leprosy. In his 1889 article, “Why the Hawaiians are Dying Out,” Sereno cited the hula as one of the causes of Hawaiian death.
“The hula dances are habitually idolatrous in practice, having their special patron gods, whom the dancers invoke and worship. The chief posturings and movements of the hulas are pantomimes of unnameable lewdness, illustrated and varied with elaborate art, and accompanied with chants of unspeakable foulness of diction and description.”

domain: history


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West Lindsey District Council says it will include concerns raised by Market Rasen residents about parking charges in the town as evidence in a review later this year.
Residents attended a public meeting, organised by Market Rasen Town Council earlier this month.
The overall conclusion, according to the town council’s report, was that the car parking charges ‘should be removed’.
That feedback was presented by the town council in what they described as a ‘positive meeting’ with WLDC officers last Tuesday (June 13)
The town council says that since parking charges were introduced in January, Rasen businesses have reported a decrease in footfall while residents say reduced car more motorists are turning to street parking.
Residents and councillors have also challenged claims by WLDC that the charges have introduced ‘equality’ across the district.
They hav told WLDC that locations such as Welton do not have charges in place and that Rasen’s ‘few facilities’ do not warrant a charge for parking.
Town councillors say these and other points were raised in the meeting with WLDC.
Coun Stephen Bunney said: “We had a very good meeting last Tuesday with WLDC officers.
“They were responsive to all the points from the town meeting – particularly the perceived effects of the charges – and promised to feed them into future planning for car parking.
“They have been asked to prepare recommendations for (district) council members which will be presented in September.”
Eve Fawcett–Moralee, Economic and Commercial Growth Director at WLDC, said: “I had a very productive meeting with the town council.
“I can confirm the District Council has listened to the concerns around the impact the car parking charges has had on the town centre viability and we will use the town council consultation as part of the evidence to review the car parking strategy.”

domain: economics


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The organizers of the January Uprising, which broke out in the Russian partition in 1863, tried to win the peasant masses over to the national cause. The Insurgent National Government had drawn conclusions from the people’s insignificant support for the November Uprising and from the tragic Galician Slaughter. In the absence of a regular army, the support of the peasants was crucial to the success of the uprising. As early as January 1863, the National Government issued a decree enfranchising the peasants in the Kingdom of Poland.
Two months later, on 12 April 1863, a similar decree, known as the Golden Writ (Pol. Złota Hramota) addressed to the rural population of Volhynia and Ukraine, was issued in Warsaw. The text, in Ruthenian, was printed in gold Cyrillic letters. The decree was part of the plan to prepare a national uprising in the whole the pre-partition area seized by Russia. The Golden Writ introduced personal freedom for the peasants, gave them their own courts independent of the lords, and enfranchised them on the land they farmed. It therefore made reference to social needs and sought to provide better conditions for the peasants than those proposed by Tsar Alexander II in his decree of 1861.
The document itself was arbitrarily modified by Marian Sokołowski, a National Government commissar, who halved the minimum area of land to be allocated to participants in the fight against the Russians. The impact of the decree was much less than expected. This was due not only to the cultural distance between the peasants and the nobility, which also existed in lands that were predominantly ethnically Polish, but also to animosities between the Orthodox Ukrainian people and the Catholic Polish nobility, which were exploited and fuelled by the Russian government. Just as in 1846 in Galicia, so now most of the addressees of the Golden Writ saw the uprising as a predominantly Polish cause spearheaded by the nobility. Although the Golden Writ did not bring the expected results, it was the last significant document written in the spirit of the community of nations of the former Polish-Lithuanian Commonwealth and has come down in history as an initiative aimed at joint action to restore brotherly independence and political understanding between the Poles and the emerging Ukrainian nation.


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Chelsea are plotting a summer move to secure the services of Jerome Boateng, whose contract at Bayern Munich expires at the end of the season.
According to SportBild, as relayed by the Metro, Thomas Tuchel has shown an interest in adding more experience to his defensive unit. As such, the newly-appointed Chelsea manager is planning a swoop for Jerome Boateng in the summer, taking advantage of his current contract situation at FC Bayern.
Boateng’s current contract at the Allianz Arena expires at the end of the season, meaning he will be available on a free transfer. Bayern Munich are determined to keep hold him for another campaign, but no contract extension has been agreed, so a move away from Bavaria could still be on the cards.
Boateng is the third high-profile Bayern Munich defender who could leave Allianz Arena for free in the summer, along with Javi Martinez and David Alaba. The latter has emerged as the hot prospect of the transfer market for obvious reasons, with Real Madrid, for one, reportedly keen on his services.
Even Chelsea have been linked with a move for the Austrian international, although it remains unlikely they will be able to compete with Real Madrid or Barcelona. Boateng, in that regard, appears as a more realistic choice for Tuchel as he aims to redesign the Chelsea backline that started with the loan departure of Fikayo Tomori.
The German tactician has placed his trust on experienced players so far, with Cesar Azpilicueta, Antonio Rudiger and Thiago Silva emerging as key members of his new-look defensive unit. Unfortunately, Silva’s contract at Stamford Bridge expires at the end of the season and the defender is set to struggle with an injury during the second half of the campaign.
Although the Blues are determined to keep hold of the Brazilian for another campaign, Boateng could be another smart acquisition. The Bayern Munich defender has a vast amount of experience at the highest level of football and is still going strong, notably remaining the first-choice centre-back under Hansi Flick this season.
However, it might be difficult for Boateng to deny the opportunity to play for Bayern for another season should the Bavarians table a contract extension offer during the remainder of the campaign. It makes up for an exciting transfer saga as these two teams vie for the services of the 32-year-old next season.