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Prostate-specific antigen (PSA) level in midlife predicted future prostate cancer (PCa) mortality in an unscreened Swedish population. Our purpose was to determine if a baseline PSA level during midlife predicts lethal PCa in a US population with opportunistic screening.
We conducted a nested case-control study among men age 40 to 59 years who gave blood before random assignment in the Physicians’ Health Study, a randomized, placebo-controlled trial of aspirin and β-carotene among 22,071 US male physicians initiated in 1982 and then transitioned into a prospective cohort with 30 years of follow-up. Baseline PSA levels were available for 234 patients with PCa and 711 age-matched controls. Seventy-one participants who developed lethal PCa were rematched to 213 controls. Conditional logistic regression was used to estimate odds ratios and the area under the receiver operating characteristic curve, with 95% CIs, of the association between baseline PSA and risk of lethal PCa.
Median PSA among controls was 0.68, 0.88, and 0.96 ng/mL for men age 40 to 49, 50 to 54, and 55 to 59 years, respectively. Risk of lethal PCa was strongly associated with baseline PSA in midlife: odds ratios (95% CIs) comparing PSA in the > 90th percentile versus less than or equal to median were 8.7 (1.0 to 78.2) at 40 to 49 years, 12.6 (1.4 to 110.4) at 50 to 54 years, and 6.9 (2.5 to 19.1) at 55 to 59 years. A total of 82%, 71%, and 86% of lethal cases occurred in men with PSA above the median at ages 40 to 49, 50 to 54, and 55 to 59 years, respectively.
PSA levels in midlife strongly predict future lethal PCa in a US cohort subject to opportunistic screening. Risk-stratified screening on the basis of midlife PSA should be considered in men age 45 to 59 years.
Prostate specific antigen (PSA) screening has been shown to reduce prostate cancer (PCa) metastases and mortality.1-4 However, PSA screening is associated with overdiagnosis and overtreatment, and it is controversial whether it does more good than harm.5,6 Smarter screening strategies are needed to improve the accuracy of diagnosing lethal PCa while minimizing harms associated with overdiagnosis and overtreatment of indolent cancer.
One proposed strategy with potential for minimizing harm while maintaining benefit is performing a baseline PSA screening in men during midlife.7-16 Because prostate carcinogenesis likely initiates in men during their fourth and fifth decade, the baseline PSA level at a younger age may be more accurate in predicting the presence of aggressive PCa, because it will be less confounded by benign prostate hyperplasia typical in older men.17 Autopsy studies show that approximately 22% of white men harbor PCa by age 60 years.18 Baseline PSA values seem to confer better predictive ability for future development of advanced PCa than do risk categories such as African American race or family history of PCa.15,19 Studies of Swedish men demonstrated that PSA level in midlife predicts for future PCa diagnosis and metastases in unscreened populations during a median 27 years of follow-up.10,11
Our objective was to determine if baseline PSA level in midlife could predict future risk of lethal PCa in a population of US men, subject to opportunistic screening, with 30 years of follow-up. We hypothesized that men with a PSA level above the median in midlife will be more likely to develop lethal PCa.
The Physicians’ Health Study (PHS) was a randomized, placebo-controlled trial of aspirin and β-carotene among 22,071 US male physicians initiated in 1982.20 From 1982 to 1984, 14,916 participants (68%) age 40 to 84 years provided a blood specimen before random assignment, and these men provide the study base for the current project. All arms of the trial have ended, and participants continue to be followed as an observational cohort. The PHS was approved by the Partners HealthCare Institutional Review Board.
Participants reported significant morbid events, including PCa, yearly in a mailed questionnaire and by postcards every 6 months. Self-reported, incident PCa cases diagnosed from 1982 to 2012 were confirmed through medical record and pathology report review by the PHS Endpoints Committee. Tumor clinical stage and occurrence of metastases were ascertained from medical records and from questionnaires sent to PCa survivors after diagnosis. Deaths were identified via family member and postal authority report and through periodic searches of the National Death Index. The Endpoints Committee determined cause of death through death certificates and medical record review and, secondarily, via next of kin.
We previously performed a nested case-control study of PSA level and PCa risk among participants with adequate plasma samples in the blood cohort.21 In that study, there were 430 cases overall diagnosed between 1982 and 1993 and 1,642 controls among participants who had not reported a diagnosis of PCa at the time the diagnosis was reported by the corresponding case, matched by age (± 1 year) at blood draw. The current case-control analysis is restricted to the 234 cases and 711 controls age 40 to 59 years at baseline. The ratio of cases to controls was 1:3 for the majority (76%) of matched sets, 1:2 for 10%, and 1:4 for 14%.
In addition to total PCa, we studied risk of lethal PCa, defined as death from PCa or development of metastatic disease either at diagnosis or during follow-up. Among 234 original patients with PCa, 60 developed lethal PCa. Among 711 men originally selected as controls, 11 developed lethal PCa later in follow-up. Thus, there were 71 lethal cases, 65 of whom died as a result of PCa and six of whom had metastatic disease but did not die as a result of PCa during follow-up. The date of death was used as the lethal event date for men who died as a result of PCa, and the date of metastatic disease diagnosis was used for men with metastatic disease who did not die as a result of PCa during follow-up. For this analysis, the 71 lethal cases were rematched to three controls (n = 213) on the basis of age at blood draw (± 1 year), being alive at the time of lethal event in the corresponding case, and having a PSA measurement at baseline. Because our focus was lethal PCa, we did not exclude men with PCa as potential controls for these 71 cases, as long as they had not suffered a lethal event at the time of the event in the case. The alternative strategy (ie, limiting controls to men without a PCa diagnosis) would have led to an overestimate of the association between PSA levels and risk of lethal PCa.
Details of the PSA assay conducted on stored plasma samples have been described previously.21 Briefly, total PSA levels were measured using the Tandem-R immunoradiometric assay (Hybritech, San Diego, CA). Intra- and interbatch coefficients of variation were ≤ 10% and ≤ 17%, respectively. Concentrations of total PSA stored in plasma stored at −80°C for 20 years have been shown to be comparable to concentrations in samples measured soon after blood draw.22
To estimate the absolute risk of lethal PCa as a function of baseline PSA, we used the nested case-control information to impute PSA levels among the cohort of participants age 40 to 59 years who provided a blood sample at baseline (n = 11,189) using similar methodology to Vickers et al10 (Data Supplement). Using PROC MI in SAS, PSA measurements were calculated over 10 imputations using predictive mean matching on the basis of follow-up time and stratified by baseline age (40 to 49, 50 to 54, 55 to 59 years) and case status (lethal case, nonlethal case, noncase) during follow-up from 1982 to 2012. Among this subcohort of men age 40 to 59 years who provided blood samples, n = 1,701 total incident prostate cancers were diagnosed from 1983 to 2012, including 127 lethal cases.
Conditional logistic regression was used to estimate odds ratios (ORs) and 95% CIs for the association between baseline PSA levels and total PCa risk, comparing cases and patients with disease overall as well as by ages 40 to 49, 50 to 54, and 55 to 59 years. We used conditional logistic regression to assess the association between baseline PSA level and lethal PCa risk after rematching the controls.
The 15-, 20-, 25-, and 30-year cumulative incidence (and 95% CI) of lethal PCa according to PSA percentile was estimated within each age group. PSA levels for the full blood cohort were imputed as described above. The mean of the individual cumulative incidence estimates was calculated over the 10 imputation sets, and CIs were determined on the log-transformed scale according to Rubin’s method.23 We averaged estimates across the 10 imputation sets to plot the cumulative incidence of lethal PCa by age group and PSA level and determine the proportion of lethal PCa captured by PSA categories according to age group.
Area under the receiver operating characteristic curve (AUC) was used to evaluate the discrimination of baseline PSA for predicting total and lethal PCa using the case-control data set. All P values were two-sided with statistical significance at P < .05. Analyses were performed using SAS version 9.2 (SAS Institute, Cary, NC) and the R programming language.
Descriptive statistics of the study populations are shown in Table 1. The mean age at blood draw was 55 years. Median follow-up time from blood draw to cancer diagnosis was 9.0 years for overall cases and 8.6 years for lethal cases.
Median PSA levels varied by age at baseline and were higher among older men (Table 2). Compared with men with measured PSA at or below the age-specific median, men with PSA above the median had consistently and significantly increased risk of total PCa across all age groups. The ORs were 7.3 (95% CI, 2.4 to 21.8) for 40 to 49 years, 7.6 (95% CI, 3.4 to 17.2) for 50 to 54 years, and 10.1 (95% CI, 5.2 to 19.6) for 55 to 59 years (Table 2). This was even more pronounced for men with PSA > 90th percentile, with ORs 32.4 (95% CI, 7.1 to 149.0), 34.6 (95% CI, 11.5 to 103.6), and 30.3 (95% CI, 13.5 to 67.7) for ages 40 to 49, 50 to 54, and 55 to 59 years, respectively.
The risk of lethal PCa was also strongly associated with PSA levels during midlife: the ORs comparing men with the > 90th percentile versus less than or equal to median levels of PSA were 8.7 (95% CI, 1.0 to 78.2) for 40 to 49 years, 12.6 (95% CI, 1.4 to 110.4) for 50 to 54 years, and 6.9 (95% CI, 2.5 to 19.1) for 55 to 59 years (Table 2). Of the lethal PCa events, 82%, 71%, and 86% occurred in men with PSA above the median at ages 40 to 49, 50 to 54, and 55 to 59 years, respectively (Table 3). However, there were nine cases of lethal PCa diagnosed among men with the lowest quartile of baseline PSA across all age groups.
The measured and imputed PSA values for participants who provided a blood specimen at baseline are shown in the Data Supplement. The cumulative incidence of PCa death or development of distant metastases by category of measured and imputed PSA, stratified by age at PSA measurement, is presented in Table 4. For men with PSA values below median at baseline, the absolute risk of developing lethal PCa in the next 30 years was low: 0.19% for men 40 to 44, 0.51% for men 45 to 49, 1.62% for men 50 to 54, and 0.59% for men 55 to 59 years of age.
PSA levels in midlife predicted future risk of PCa overall as well as risk of lethal PCa with good discrimination (Table 5). For lethal disease using measured PSA levels, the AUC was 0.75 (95% CI, 0.53 to 0.97) for men 40 to 49 years, 0.72 (95% CI, 0.55 to 0.89) for men 50 to 54 years, and 0.76 (95% CI, 0.67 to 0.84) for men 55 to 59 years.
In this prospective study among US men, we found that a single baseline PSA level measured during midlife predicted subsequent development of lethal PCa with good accuracy over 30 years of follow-up. Opportunistic PSA screening occurred during our follow-up time, which spanned cases diagnosed during pre-PSA and PSA eras. Assuming that opportunistic screening was at least somewhat effective in reducing mortality,24 our results are likely to underestimate the association between baseline PSA and lethal PCa in the absence of any screening. These data identify subgroups of men, on the basis of their PSA levels at a given age, with widely divergent lifetime risk of PCa death, who therefore could benefit from screening intervals tailored to their actual magnitude of risk. An increased risk of lethal PCa was present for men with PSA levels above the median and especially in men with PSA levels above the 75th and 90th percentiles. In our data, one of seven men with PSA > 3.0 ng/mL at 55 to 59 years and one of 12 men with PSA > 2.1 ng/mL at 50 to 54 years died as a result of PCa within 30 years. These results support prior studies showing value of baseline PSA conducted among unscreened men in Sweden.10,11
These findings do not necessarily imply that prostate biopsy or definitive treatment is immediately required in younger men with higher PSA levels at baseline, because this could lead to overdiagnosis, but only that they undergo more intensive PSA screening to enable earlier identification of cancer and potential cure while still possible. If baseline PSA is markedly elevated (> 90th percentile) for age, cumulative incidence for lethal PCa at 30 years is substantial, with rates of 4.5%, 8.4%, and 14.1% for men age 45 to 49, 50 to 54, and 55 to 59 years, respectively.
PSA screening guidelines typically recommend screening take place between ages 55 to 69 years, because there is no published randomized trial of PSA screening in men younger than the age of 50 years and because incidence of PCa in younger ages is quite low. Before age 45 years, the cumulative incidence of lethal PCa at 15 years is low, and metastatic cancer is rarely diagnosed. Our results showed no PCa deaths within 15 years in men younger than 45 years with a PSA level below the median at baseline. These findings may inform discussions of an appropriate age range for screening initiation, because men younger than 45 years see little benefit, and lethal disease is likely to be caught early enough at a subsequent screen.
The ideal screening interval for men depending on baseline PSA level in midlife is unknown. We found that risk of developing lethal PCa in the next 30 years among those with baseline PSA levels below the median was < 2% at ages 40 to 59 years. Although risk was small, it remained present, and so screening should be continued, albeit with longer intervals. It seems that baseline PSA level below the median at age 45 years followed by repeat measurements at 5-year intervals would capture most lethal cases, given that the 15-year cumulative incidence for lethal PCa at age 40 to 44 years is zero and in the 45 to 49 year age group only 0.07%.
We investigated whether one low PSA level at age 40 to 49 years is sufficient to allow men to be exempted from further screening. We found that compared with men having PSA levels above the median of 0.68 ng/mL, men age 40 to 49 years with PSA levels below the 25th percentile of 0.52 ng/mL were at a decreased risk, albeit nonsignificant, of lethal PCa (OR, 0.36; 95% CI, 0.04 to 3.30). However, despite this low PSA level, two men with baseline levels below 0.52 ng/mL died as a result of PCa during follow-up. The cumulative incidence of lethal PCa for men age 40 to 44 and 45 to 49 years with a PSA level below the 25th percentile (0.53 ng/mL) at 30 years is 0.37% (95% CI, 0.05 to 1.70) and 0.97% (95% CI, 0.30 to 2.49), respectively. Thus, it would be prudent to conduct another PSA test during the lifetime of men age 40 to 49 years, even if the first measure is exceptionally low, because there still exists a small risk of PCa death.
We then sought to determine whether it is safe to stop PSA screening at age 60 years. We found that men age 55 to 59 years with PSA levels below the median of 0.96 ng/mL were at low risk of lethal PCa. The cumulative incidence of lethal PCa in this age group was 0.59% (95% CI, 0.25 to 1.22) for PSA levels below the median at 30 years. Fully 86% of lethal cases occur in men with PSA above the median. This suggests white men with PSA level below 1.0 ng/mL at age 60 years might reasonably forgo further PSA screening. This requires further study but is consistent with a study comparing a nonscreened population (Malmö) with a screened population (Göteborg screening trial) that showed no reduction in PCa mortality, but an important increase in overdiagnosis, for rescreening men with a PSA level < 1.0 ng/mL at age 60 years.25 In contrast, rescreening men with PSA levels > 2.0 ng/mL at age 60 years had a large reduction in PCa mortality with minimal overdiagnosis: only 23 men needed to be screened and six diagnosed to avoid one PCa death at 15 years.1,25
In our analysis of the ability of PSA at midlife to predict total and lethal PCa, the AUCs were higher for predicting total (AUC, 0.83 for 40 to 49 years) versus lethal (AUC, 0.75 for 40 to 49 years) PCa. In contrast, in the Malmö Preventive Project, the baseline PSA values in men age < 50 years more strongly predicted advanced PCa (AUC, 0.75) compared with total (AUC, 0.72) risk, likely due to the absence of routine screening in Sweden.11 The higher discrimination of PSA for total cancer in the current study is likely a function of verification bias. In a screened population, men with higher PSA are more likely to be subject to biopsy and thus have an accordingly higher risk of diagnosis. The lower discrimination of PSA for lethal cancer is best explained in terms of risk reduction associated with screening: a man with a higher PSA who is destined to develop lethal cancer may have that cancer detected early because of opportunistic screening, leading to cure.
There are few study populations available in any country that have access to baseline blood samples, excellent accounting of lethal PCa outcomes, and the extensive follow-up required to investigate this question. Furthermore, because this is a US population subject to opportunistic PSA screening, it is generalizable to a contemporary population. A similar case-control design was previously used among Swedish men age 27 to 56 years with extremely low PSA testing rates in the Malmö Preventive Project.10 They found risk of death from PCa was also strongly associated with baseline PSA: 44% (95% CI, 34% to 53%) of deaths occurred in men with PSA concentration in the highest 10th of the distribution of concentrations at age 45 to 49 years (≥ 1.6 ng/mL), with a similar proportion for the highest 10th at age 51 to 55 years (≥ 2.4 ng/mL; cumulative incidence, 44%; 95% CI, 32% to 56%).10
Our study is subject to limitations. Despite decades of follow-up, we have limited lethal events, especially in younger age groups, contributing to wider CIs. However, it is worth noting that the wide CIs are due, in part, to the fact that PSA is so strongly related to lethal disease risk, resulting in a small number of events in the reference group with low PSA levels. An unknown proportion of case-control participants might have undergone opportunistic PSA testing before study inclusion in 1993. Even though approval of the PSA test for the purpose of screening asymptomatic men for PCa by the US Food and Drug Administration did not occur until 1994, uptake in the United States was present before this, and it is estimated that PSA testing increased from < 5% of white men in 1989 to approximately 40% in 1994.26 The impact of this opportunistic screening is likely limited, because our primary study outcome was lethal PCa and not incidence.
It is also important to note that the cumulative incidence of PCa mortality in this study was 4.9% in 2012. This is higher than the general population because of decreased cardiac mortality among this physician group. Finally, the study population consisted primarily of white men. Although studies have shown midlife PSA to be predictive of PCa diagnosis in African American men, no study has evaluated risk of PCa metastases or death, despite there being a greater risk of diagnosis and mortality compared with white men.9,27,28
In conclusion, PSA levels in midlife predict strongly for subsequent development of lethal PCa in a cohort of American men subject to opportunistic PSA screening. Risk-stratified screening on the basis of midlife PSA should be considered in men age 45 to 59. Men with PSA below median at age 60 years (< 1.0 ng/mL) are unlikely to develop lethal disease.
We thank Meir Stampfer for his valuable insight and guidance. We also thank the participants of the Physicians’ Health Study for their dedicated participation in the study. The co-first authors M.A.P. and J.L.B. had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
The Physicians’ Health Study was supported by the National Institutes of Health Grants No. CA-097193, CA-34944, CA-40360, HL-26490, and HL-34595. This work was also supported by the Department of Defense Prostate Cancer Research Program Grant No. W81XWH-12-1-0072 (J.L.B.), Dana-Farber Cancer Institute Mazzone Awards Program (J.L.B. and M.A.P.), and the Prostate Cancer Foundation Young Investigator Award (L.A.M.); M.A.P. is an American Urological Association Urology Care Foundation Scholar. Additional funding support provided from the National Cancer Institute Grants No. R33 CA127768-02, P50-CA92629, and P50-CA090381; Swedish Cancer Society Grant No. 3455; Fundaçion Federico; the Sidney Kimmel Center for Prostate and Urologic Cancers; David H. Koch through the Prostate Cancer Foundation; and a Cancer Center Support Grant from the National Cancer Institute made to Memorial Sloan Kettering Cancer Center Grant No. P30-CA008748 (S.C., D.S., and A.V.; PI: Craig B. Thompson).
The views expressed in the submitted article are the authors’ own and not an official position of any institution or funder.
Authors’ disclosures of potential conflicts of interest are found in the article online at www.jco.org. Author contributions are found at the end of this article.
See accompanying editorial on page 2684
Conception and design: Mark A. Preston, Julie L. Batista, Adam S. Kibel, Lorelei A. Mucci
Financial support: Lorelei A. Mucci
Administrative support: Lorelei A. Mucci
Collection and assembly of data: Howard D. Sesso, Peter H. Gann, Lorelei A. Mucci
Data analysis and interpretation: Mark A. Preston, Julie L. Batista, Kathryn M. Wilson, Sigrid V. Carlsson, Travis Gerke, Daniel D. Sjoberg, Douglas M. Dahl, Howard D. Sesso, Adam S. Feldman, Peter H. Gann, Andrew J. Vickers, Lorelei A. Mucci
Manuscript writing: All authors
Final approval of manuscript: All authors
The following represents disclosure information provided by authors of this manuscript. All relationships are considered compensated. Relationships are self-held unless noted. I = Immediate Family Member, Inst = My Institution. Relationships may not relate to the subject matter of this manuscript. For more information about ASCO's conflict of interest policy, please refer to www.asco.org/rwc or jco.ascopubs.org/site/ifc.
No relationship to disclose
No relationship to disclose
Travel, Accommodations, Expenses: Sanofi
No relationship to disclose
Consulting or Advisory Role: OPKO Health
Stock or Other Ownership: Pfizer, Amgen, Johnson & Johnson, Merck, Bard Medical
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Consulting or Advisory Role: Myriad Genetics, Olympus
Research Funding: Myriad Genetics
Travel, Accommodations, Expenses: Myriad Genetics
Research Funding: GlaxoSmithKline (Inst), Receptos (Inst)
Consulting or Advisory Role: Sanofi, Dendreon, Profound, Tokai Pharmaceuticals, MTG
Consulting or Advisory Role: OPKO Health
Patents, Royalties, Other Intellectual Property: Arctic Partners, OPKO Health
No relationship to disclose


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The PATCH Lifestyle Concept Store, in the heart of Porto's artistic district, is a store created around the concept of “vintage” yet carrying this imagination to the contemporary. In this establishment our customers can find mostly used products with a "vintage" style, from clothing, home accessories, furniture, lighting design and stationery, decorative objects, among many other options. At PATCH you will also enjoy the space’s decoration, along with designer lighting and rustic furniture.
Vintage decoration, vintage clothing
Monday to Saturday: 10:30-20:00
This store has no reviews.
Promotions are one of the strategies shop owners can use to sell their products, renew collections or simply win more customers and advertise their business. At Shop in Porto, our shop owners can advertise online promotions in their stores over a period of time, making them visible to customers.
We are here
Rua do Rosário, 193

domain: design


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From fairy tales that have been transported into the modern day and feature scenarios children can relate to and learn to classical stories to enjoy filled with exciting interaction is box is sure to be loved by young and old alike. .
Fairy Tales help readers develop critical thinking skills and promote imagination. As Albert Einstein said, “if you want children to be intelligent read them fairy tales”. Fairy Tales also aid in building emotional resilience in a safe environment (reading with mum/dad) through exposure and guided conversation.
There are 3 fairytale stories
Jack breaks the Beanstalk, Sue Nicholson, Falvia Sorrentino - is a story about honesty.
Snow White and the Star Striker ,Sue Nicholson, Falvia Sorrentino - is a story about teamwork
My first storytime, The Gingerbread Man - Fran Manushkin & Tammie Lyon - The perfect beginning reader.
The individual book guides included in the parent booklet will provide an overview of these wonderful books, suggestions on how to enhance the reading experience and educational tips to extend your reader.
Book inspired play activities and crafts:
Make your own fairytale scene
Learn to draw gingerbread man
Jack breaks the beanstalk story review writing frame
Secret word finder
Fairytale colouring in
Plant your own magic beans
Your reader will have lots fun colouring in with their Gingerbread man stacking crayons engagement gift.
Plus instructions on how to make a gorgeous fairy tale castle made using the delicious zucchini recipe from Simone from @playwithfood_au

domain: library


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Scores based on about 99 responses to Indeed's survey on work happiness
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From empowering seniors to live more independently to providing families with real peace of mind to celebrating our own employees, at Meridian Senior Living, our team has one core belief: Everyone deserves a great life. And we spend every minute of every day striving to ensure every person who walks through our doors truly can enjoy a great life.
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Management needs a lot of work
Residents are amazing and appreciate you. There are many residents who should be in different facilities-they take anybody and don’t take the residents needs into consideration which is sad and dangerous. All that’s cared about is the money paid in.
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Toxic culture-poor management
It was a very toxic culture, lots of drama. You can’t trust anyone, and someone is always trying to get someone in trouble. Hours weren’t good, they would only give you 7 hours a day including lunch. Management was not trust worthy, you would talk to one, and the next day everyone knew your business. Residents were also not taken care of properly, food - more...
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domain: sociology


Forum: Liquid Lounge
Here's the bit that makes me just shake my head:
"The gun, a .22 caliber revolver, was noticed as missing after Monday's shootings and fits the description of the pistol that reportedly was used to kill three students and wound two others at Chardon High School, said Henderson, a retired police officer and former Geauga County sheriff. He said he has spoken to the grandfather, Thomas Lane, about the gun.
The suspect's grandfather believes the gun is the same, "because the gun was there the day before, in the barn," said Henderson, 74, who says he's been friends with the boy's family for nearly 50 years.
A law enforcement official familiar with the investigation said the gun used in the shooting, a Ruger .22-caliber Mark III target pistol, was bought legally in August 2010 from a gun shop in Mentor, Ohio."
Okay - a .22 Ruger Mark III - pretty unambiguous, right? So, a little Google search, and the first hit is:
This is NOT a revolver. (The absence of anything that revolves - like a cylinder - is a dead giveaway.) I know this for certain because I actually own one of these - it's the handgun I've shot the most in the past 10 years - but anyone with a computer and an internet connection could get the correct information in a matter of seconds.
The mind boggles that this sort of blatant error not only gets into the story, but then gets by editors, factcheckers, and so forth. Absolutely pathetic reporting.
I think that among certain of the uninitiated, anything that is a handgun becomes a "revolver" Gordo New


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Can contractions be painless?
For you, early contractions may feel quite painless or mild, or they may feel very strong and intense. The pain you feel can also differ from one pregnancy to the next, so if you’ve been in labor before you might experience something quite different this time around.
How do I know if my contractions are real?
You know you’re in true labor when:
- You have strong and regular contractions. A contraction is when the muscles of your uterus tighten up like a fist and then relax. …
- You feel pain in your belly and lower back. …
- You have a bloody (brownish or reddish) mucus discharge. …
- Your water breaks.
How do contractions feel when they first start?
Early labor contractions may feel as if you have an upset stomach or trouble with your digestive system. You may feel them like a tidal wave because they increase and finally subside gradually. Some women feel intense cramps that increase in intensity and stop after they deliver.
How do you feel 24 hours before labor?
As the countdown to birth begins, some signs that labor is 24 to 48 hours away can include low back pain, weight loss, diarrhea — and of course, your water breaking.
What is silent labor?
The concept of silent birth is a mandatory practice in Scientology doctrine. It is based upon the principle that expectant mothers must be provided the utmost care and respect and Hubbard’s words: “Everyone must learn to say nothing within the expectant mother’s hearing using labor and delivery.
What is the 5 1 1 rule for contractions?
The 5-1-1 Rule: The contractions come every 5 minutes, lasting 1 minute each, for at least 1 hour. Fluids and other signs: You might notice amniotic fluid from the sac that holds the baby. This doesn’t always mean you’re in labor, but could mean it’s coming.
When should I start timing contractions?
You may want to start timing your contractions when you think labor has started to see if there is a pattern. You may also want to time contractions for a bit after there has been a change in how the contractions feel. That can give you a better idea of how much time you have to rest between each contraction.
Can you be in labor and not know it?
It’s very unlikely that you will suddenly go into labor without warning. Your body will let you know that you’re close to the big day, so you can make sure your hospital bag is packed, and be ready to go to the hospital when the time is right.
Is it a contraction or baby moving?
If your entire uterus is hard during the cramping, it’s probably a contraction. If it’s hard in one place and soft in others, those are likely not contractions—it may just be the baby moving around.
Where on Bump do you feel contractions?
Sometimes it will feel like a tight band around the top of your womb, which can be felt externally by placing a hand on your bump. Some women feel contractions most strongly in the back which is usually caused by their baby is facing a certain way (back to back).

domain: health


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Life Is A Gift Welcome Box Sign
Regular price $10.99
Life is a Gift Sign is a wooden sign that features a deep stone gray background and pastel yellow lettering. It features a heartwarming welcome message for new visitors to your home. Sign measures 10" high by 8" wide and 1" deep.

domain: artistic


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The old history behind the new cityPosted 19th June 2023
We love peeking into the past and sharing the secrets and stories of our local history, but this month, we thought we would shine a light on all that the Museum has to offer.
It’s a constantly expanding collection and the only one that tells the complete history of the place we all call home…
Yes, Milton Keynes is a new city, but the space it occupies is rich in history – and here at Milton Keynes Museum, we have been sharing that history for 50 years.
When you enter the Museum you do so through the front door, but in Victorian times only important visitors were afforded that privilege!
As we have explored in the past, Stacey Bushes Farm was bought by Oxford’s Dr Radcliffe, but that farmhouse has long-since disappeared and the farmstead you visit today was built in 1847.
Around the same time that work on the farmhouse progressed, someone planted a Cedar of Lebanon tree, which is magnificent and dominates the space to the front of the property.
Once inside, you’ll head straight into The Parlour. On a chilly day, the roar of an open fire as the winter sun peeks through the curtains makes the space instantly inviting.
Victorians used The Parlour as a space to display their most favourite possessions – they wanted to impress their visitors, and back then, the pianola and fancy curiosities were to be envied.
Across the hall, a room dedicated to Home Entertainment is to be enjoyed.
Forget downloads and music streams. Victorians were charmed by Roller Organs, Seraphones and Polyphon music boxes, and when you’ve brushed up on those, you can learn what it was like to hear a recorded voice for the first time from cylinders played on Edison’s phonograph.
It was the cutting edge technology of its time and its arrival would have been met by much excitement.
Our Servants’ Room explores what life was like for those in service – a ‘career’ which began at just 13 years old.
Today, we can order food online, or ask a robot to deliver it to our door. In the 19th century, things were very different, and when you had the food, you didn’t store it in a fridge – there were no fridges!
The Kitchen – another hot spot on a cold day – is also the place to make fresh toast using the range. There were no shortcuts in Victorian times, but they did have tools for everything and we have many of them on display. Our wonderful volunteers will be happy to explain how they worked and let you try many of them out yourselves. Wherever possible, we like to be a hands-on Museum.
If you fancy a spot of window shopping with a difference, our Street of Shops is the place to head to; this is a truly authentic, unique opportunity to browse the stores of yesteryear which existed in our local towns.
We have the original facades for many shops, including the art deco appeal of the Newport Pagnell Co-op, Stony Stratford’s long-since gone watering hole, The Angel, and the earlier branch of the Cox & Robinson chemist, complete with many original fixtures and fittings.
Contents of the ironmongers came from the long and trusted Odell name, and from Olney business Sowman’s, which was founded before 1822 and declared themselves, ‘Electric and hot water engineers, general furnishings and building ironmongers, shoe grindry merchants, house furniture, gas, tin and coppersmiths, artificial manure merchants and crockery merchants.’
If they didn’t have what you were looking for, no-one would!
If you came over ill while shopping at these stores back in their time, you might have needed an ambulance. Our Bischoffsheim dates to 1903, and was hand carried. Reassuringly, it bears no comparison to today’s high-tech ambulances. The Bischoffsheim have their place in history though, and were widely used by the police – they weren’t withdrawn from use until 1938.
Children left school at a younger age than today, but the importance of learning hasn’t changed.
Pupils were expected to show respect for their teacher and for their lessons, but the punishment was more severe. Boys not willing to toe the line might well feel the cane across their backsides or on the hands.
Finger stocks were used on those who would bite their nails, fidgeted or would not sit still during lessons – will you be brave enough to try them for size in our Schoolroom on your visit?
Continue on and you will come to the Barn, which will explore our relationship with the land which we were all connected in the not-too-distant past; we understood its value, knew the changing seasons, and could tell the time from the sun.
This ability is sadly largely forgotten today. The barn is also full of the equipment that our ancestors used in the efforts to fend off starvation and provide for the community.
The Communication Gallery is always a smash hit with children and adults who are actively encouraged to dial a phone or use the switchboard – very novel when you consider today’s clever tech!
We do have a wide-variety of mobile phones too, including some early examples that you might well recognise. And Buzby the cartoon bird who fronted TV ads for Post Office Telecommunications (remember the catchphrase, ‘Make someone happy with a phone call?’) is resident here.
How do you take your news today? On your phone, possibly?
In Wolverton, ‘The Print’ was McCorquodale’s Print Works which offered jobs to women who couldn’t work at the Works across the road, and was the way to share the news of the day.
The machines on display in our Print Room show 150 years of printing and are still in working order.
As you move into the Hall of Transport, you will be greeted by the magnificence of the world’s biggest steam tram, which once ferried workers between Stony Stratford and the Railway Works.
Sedan Chairs were popular during the 1600s and comprised a cabin mounted on poles, which would be carried by two men. It was a rudimentary forerunner of today’s cab, and just the same as today, they needed to be licensed too.
Canals and waterways were crucial when it came to transportation of goods, and they have representation here, as do bicycles that span the centuries; from Penny Farthings, through to Chopper bikes.
Back in the 1859s, workers at Wolverton Works had no baths at home, and so a bath house was built for them to scrub up.
The hall of transport includes items from the bath house, including one of the baths.
And we have a lovely example of a horse-drawn steam fire engine, which came from Newport Pagnell.
The first recorded use of the ‘Lovat’ as she became known was at the Unionist Working Men’s Club on Boxing Day 1912. The engine remained in service until 1939.
This brief stroll around the Museum is just a glimpse at what is on offer, and we hope you’ll come to explore more of the history on your doorstep with us.
Our outside space is perfect for relaxation and enjoying the fresh air – we have a nature trail, the Bloomer locomotive, and you can stroll around our kitchen and war-time gardens which are rich in vegetables and have plenty of petal power during the summer months and beyond.
And a visit to the Museum could never be complete without catching sight of our ‘moo-dy’ residents, the world-famous concrete cows!
As we celebrate our 50th year as a Museum we are working on our future; which will include taking visitors back to our ancient past, before dropping you into the here and now.
After all, what happens today is tomorrow’s history…
Milton Keynes Museum is one of the best interactive museums, a perfect outing for all ages, staffed by friendly volunteers, and highly recommended by visitors on TripAdvisor.
This feature was written by Milton Keynes Museum. Find out more about forthcoming events and see our opening times at: miltonkeynesmuseum.org.uk

domain: history


text:
Genres: Horror, Science Fiction, Thriller Back
Jessica Clem is a writer, marathon runner, and Stephen King fanatic currently based in Omaha, Nebraska. She holds a B.A. in English and a M.S. in Urban Studies, and works as a content strategist for a marketing agency. In her free time, she can be found hogging all the good books at the library, running on the local trails, and adding new spirits to her home bar collection. She has been published in Ms. Magazine, and various local publications in Omaha. She is happily single and spends her days with a beloved Yaris named Egg.


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Of all the troubling promises President Trump made during the 2016 presidential campaign, the promise to round up and deport undocumented immigrants is the one the president had religious stuck with – and with a host of tragic human consequences. PBS reported that, through December 2017, immigration arrests were up 45 percent and the arrests of undocumented immigrants with no criminal record was up 145 percent under the Trump crackdown.
This dramatic escalation of arrests by the U.S. Immigration and Customs Enforcement (ICE) has focused more effort on immigration crime in general. But the most alarming facet of the Trump crackdown is ICE’s targeting immigrants with no criminal records. The arrest of undocumented immigrants with no criminal records more than doubled in New Jersey last year, which similar increases in other states.
The Trump administration and proponents of these policies claim that undocumented immigrants increase the risk of crime and terrorism in the U.S. They also invoke the racist-driven notion that undocumented immigrants take advantage of taxpayer benefits without themselves paying taxes.
Because of this, undocumented immigrant hardliners declare they all undocumented immigrants should be deported to keep Americans safe and ensure law and order.
The Trump crackdown has increased the chasm between those advocating a pathway to citizenship and those clamoring for deportation. The character and foundation of this nation was shaped and constructed by immigrants. The original American colonists, it should be remembered, were actually “illegal immigrants.” They thought of themselves as citizens of Great Britain who came to the land now known as the “United States of America” to steal and conquer it by any means necessary.
Studies tend to agree with this perspective, showing that immigrants (regardless of their citizen status) are less likely to engage in violent criminal activities than U.S.-born citizens. The parents of the president’s wife, Melania, are poised to become citizens of the United States. They left their homeland in Slovenia to make a fresh start in America—the same goal that has been pursued by overwhelming percentage of undocumented immigrants.
The result is that the Trump administration’s increased enforcement of immigration policies in major cities across the U.S. has been met with not just with the dismay of many local citizens and lawmakers, but in some areas active resistance. This conflict is somewhat reminiscent of the Fugitive Slave Act of 1850, in which lawmakers and residents of Northern states actively opposed the apprehension of escaped slaves.
Is ICE the New Fugitive Slave Act?
Supporters of the new immigration policies are predominantly rural or middle-class white Americans occupying states where undocumented immigrants are relatively uncommon. In contrast, U.S. citizen residents of big cities, which are diverse and contain a high proportion of undocumented immigrants, tend to oppose these policies.
If you look at history, this dynamic is something that sounds an awful lot like the Fugitive Slave Act. This Act was signed into law in 1850, and required state and local governmental officials and citizens of the North to aid slave owners and slave hunters who came to capture and re-enslave runaway slaves.
The North strongly opposed this new law, with many local governments ruling that the Fugitive Slave Act compromised State’s Rights protected by the 10th Amendment. Citizens even took to the streets to oppose and resist the arrest of African Americans.
Starting to sound familiar?
The Fugitive Slave Act may very well be one of the biggest factors that ultimately led to the Civil War as these two opposing viewpoints continued to clash without resolution. We’re obviously not there yet, but might we be in a decade’s time?
How to Deal with It If You Are Charged with an Immigration Crime Now
It is likely that many state and local governments will continue to oppose ICE immigration enforcement, citing State’s Rights. This, combined with actions you can take on your own, should minimize your chances of running afoul of immigration.
They won’t completely eliminate the risk, though, and under our current political climate the arrests and departments of undocumented immigrants is likely to continue to increase. If you find yourself charged, you need to take it very seriously and immediately seek help from an experienced Texas immigration attorney who can help protect your rights.

domain: law


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Ajithfans - Actor Ajith Kumar E-Fans Association
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Tamilnadu Ethu Namma Thala Nadu
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domain: entertainment


text:
These earrings with a special cat design are a real summer essential! Combine these earrings with your awesome festival outfit and other jewelry! These earrings are super on-trend accessories that will complete your festival outfit!
Do you have any questions about this item? Contact us through our contact page or chat with us directly!


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State Rep. Randy Frye (R-Greensburg) welcomes local pastor Tommy Beatley Monday, Jan. 27, 2020, to the Statehouse. Beatley is the pastor at Delaware United Methodist Church in Osgood, and was invited by Frye to lead the Indiana House of Representatives in prayer before the opening of session.
STATEHOUSE (Jan. 23, 2020) – The Indiana House of Representatives today approved State Rep. Chuck Goodrich’s (R-Noblesville) bill that would break down barriers to career opportunities for students from low-income families.
STATEHOUSE (Jan. 28, 2020) – The Indiana House of Representatives today approved allowing Hamilton County to hire an additional magistrate. State Rep. Donna Schaibley (R-Carmel) said the new magistrate would preside over minor offenses and hold preliminary hearings for more serious crimes.
STATEHOUSE (Jan. 23, 2020) – The House Public Health Committee Wednesday voted in favor of a bill authored by State Rep. Donna Schaibley (R-Carmel) providing Hoosiers with timely, health care pricing information.
STATEHOUSE (Jan. 28, 2020) – The House of Representatives today approved State Rep. Ethan Manning’s (R-Denver) legislation to prevent deaths from low head dams with a 95-1 vote.
The Indiana House of Representatives on Tuesday unanimously supported State Rep. Matt Hostettler’s (R-Fort Branch) legislation allowing Gibson County to hire a new magistrate.
PHOTO CAPTION: (From left to right) State Reps. Matt Hostettler (R-Fort Branch), Holli Sullivan (R-Evansville), Wendy McNamara (R-Evansville) and Ron Bacon (R-Chandler) pair sneakers with their suits to help kick off February as National Cancer Prevention Month on Wednesday, Jan. 29, 2020, at the Statehouse. The Indiana House of Representatives participated in the Suits and Sneakers Challenge, an annual event hosted by the American Cancer Society and National Association of Basketball Coaches, to help raise awareness. The American Cancer Society recommends a healthy diet and exercise to significantly reduce cancer risks.
PHOTO CAPTION: (From left to right) State Reps. Stephen Bartels (R-Eckerty) and Shane Lindauer (R-Jasper) pair sneakers with their suits to help kick off February as National Cancer Prevention Month on Wednesday, Jan. 29, 2020, at the Statehouse. The Indiana House of Representatives participated in the Suits and Sneakers Challenge, an annual event hosted by the American Cancer Society and National Association of Basketball Coaches, to help raise awareness. According to the American Cancer Society, the use of tobacco products is linked to many types of cancer, and recommends avoiding this product to significantly reduce cancer risks.
STATEHOUSE (Jan. 28, 2020) – The Indiana House of Representatives Tuesday voted in support of State Rep. Dale DeVon's (R-Granger) bill that would help new teachers recognize and properly respond to signs of trauma in children.
According to the U.S. Department of Health and Human Services Child Maltreatment Report, there were 25,731 child abuse victims in Indiana in 2018. DeVon said young victims of trauma may experience social, emotional and academic setbacks. His legislation would add trauma response and recognition education to the training new educators must receive in order to qualify for their first teaching license.
STATEHOUSE (Jan. 27, 2020) – The Elections and Apportionment Committee advanced State Rep. Alan Morrison’s (R-Brazil) bill empowering local legislators to move municipal elections to even-numbered years, which he said could increase voter turnout and save towns money on conducting elections.
STATEHOUSE (Jan. 27, 2020) – The Indiana House of Representatives voted in support of legislation co-authored by State Rep. Dale DeVon (R-Granger) that would help Hoosier children with development delays and disabilities receive timelier care through Indiana’s First Steps program.
State Rep. Ron Bacon (R-Chandler) honored members of the Castle High School archery team on Monday at the Statehouse.
STATEHOUSE (Jan. 27, 2020) – State Rep. Denny Zent (R-Angola) today at the Statehouse presented a resolution urging the Indiana Department of Transportation to rename a section of U.S. 20 as the Indiana Medal of Honor Memorial Highway.
According to Zent, a U.S. Army and Air Force veteran who serves on the House Veterans Affairs and Public Safety Committee, designating a national Medal of Honor Memorial Highway is a coordinated effort among the 12 states impacted by U.S. 20.
The Indiana House of Representatives Tuesday voted in favor of legislation co-authored by State Rep. Randy Frye (R-Greensburg) that would make interfering with fire scenes a crime.
This session, the Indiana House of Representatives is joining forces with the Indiana Legion to collect and distribute hygiene and food items to homeless veterans. Our goal is to assemble 500 care packages for the Indiana Legion to distribute statewide to veterans in need, and there are opportunities for everyone to help in this effort.
In Indiana, our nation’s capital and around the country, thousands came together this month to stand for the unborn at March for Life rallies. Abortion is one of the great tragedies of our time, and I’m encouraged to see so many Hoosiers affirm the right to life and protecting the unborn. This year marks the 47th anniversary of the U.S. Supreme Court’s Roe v. Wade decision, which legalized abortion in the United States at the federal level, and it is more important than ever for us let the world know why we march for life and how we are going to defend life in 2020.
STATEHOUSE (Jan. 24, 2020) – The Veterans Affairs and Public Safety Committee unanimously approved State Rep. Peggy Mayfield’s (R-Martinsville) legislation prohibiting the use of a firefighting foam containing dangerous chemicals from being used for training.
STATEHOUSE (Jan. 23, 2020) — State Sens. Phil Boots (R-Crawfordsville) and Brian Buchanan (R-Lebanon), and State Reps. Tim Brown (R-Crawfordsville), Donna Schaibley (R-Carmel) and Jeff Thompson (R-Lizton) honored the Western Boone football team on Jan. 23, 2020, with Senate Concurrent Resolution 10.
State Reps. Randy Lyness (R-West Harrison) and Cindy Ziemke (R-Batesville) this week voted in support of a bill that aims to break barriers for students from low-income families.
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domain: news


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India warns Maldives over airport deal row 05 декабря 2012, 11:16
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India warned its neighbour the Maldives on Monday that it might freeze annual aid worth $25 million amid anger over an attempt to kick out the Indian firm managing the main airport in the country, AFP reports.
Last week, the new Maldives government gave five days to Indian infrastructure company GMR to leave after prematurely ending a 25-year management lease signed for the archipelago's international airport in the capital Male.
In a further blow over the decision, the Maldives government lost a case in the Singapore High Court on Monday where GMR won an injunction that stays the cancellation of the contract, the company said.
The move over the airport angered New Delhi and raised concerns about the investor climate at a time when the Maldives is seeking foreign financing for tourism projects after a year of political turmoil.
"We are not happy with the way Maldives cancelled the GMR airport deal. This has surely left an impact on our bilateral ties," an Indian foreign ministry official told AFP, asking for anonymity.
A second official in the ministry said next year's financial aid of $25 million would be provided only "after every aspect of the airline deal is reviewed".
"A decision whether the money should be given or not will be taken soon," he said, also on condition of anonymity.
Bangalore-based GMR Infrastructure had signed the deal to manage the airport in 2010 under former President Mohamed Nasheed, the country's first democratically elected leader who was ousted after violent protests in February this year.
Nasheed's deputy, Mohamed Waheed, assumed the presidency in what the former government initially described as a "coup" but which has since been judged a legal transfer of power.
Waheed's government, which has aligned more closely with a hardline Islamist party, objected to the privatisation of the airport carried out by Nasheed and said the deal was corrupt.
GMR, which won a contract to upgrade and operate the international airport in Male and build a new terminal, said in a statement that it had won "injunctive relief" against the applicability of the cancellation order.
The Singapore High Court, where arbitration was ongoing "was pleased to grant this stay in favour of GMIAL", GMR said in a statement referring to the consortium running the aiport which includes Malaysia Airports Holdings.
Officials at GMR termed the Singapore court verdict a "victory of light over darkness".
"The government of Maldives had made a unilateral move and completely irrational move and the court recognised it," a senior GMR official told AFP.
Earlier this month, senior Indian officials in New Delhi welcomed an injured opposition Maldivian politician who claimed he was beaten up by police in what was viewed by some as a sign of concern in India about political violence in its neighbour.


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Pancreas Social MediaFound 27 results for "Pancreas"
Pancreas Hashtags 3 of 27
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Cystic Fibrosis is a disease passed down through families that causes thick, sticky mucus to build up in the lungs, digestive tract, and other areas o…
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Pancreatitis is inflammation of the pancreas.
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The innovative 16th International Conference on Advanced Technologies & Treatments for Diabetes (ATTD 2023) will gather once again clinical practi…
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National Congress of the British Transplantation Society. Held 4-6 March, 2020 at ICC Belfast.
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The Midwinter Conference offers concurrent programs in Radiology, Radiation Oncology, and Nuclear Medicine, providing participants with the opportunit…
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the 13th IHPBA WORLD CONGRESS. will take place in Geneva at PALEXPO, conveniently located next to the airport and the charming old town, as well as th…

domain: medical


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Tales Of Destiny Characters
A selection of articles related to tales of destiny characters.
Original articles from our library related to the Tales Of Destiny Characters. See Table of Contents for further available material (downloadable resources) on Tales Of Destiny Characters.
- Baba Yaga: A Demon or A Goddess?
- Growing up in Kiev, Ukraine, I loved reading and listening to fairy tales. These stories, filled with Slavic flavor, were opening up a new world for me, a world where one is to learn lessons and always to succeed, a world in which no matter how many hardships...
Deities & Heros >> Slavic
- Celtic Gods and Heros: Introduction to Celtic Mythology
- Youngsters of school age almost effortlessly learn about the gods and heroes of Greek and Roman mythology. Names like Zeus, Hercules, Diana, Ulysses, Mercury, Venus, and others become widely familiar. Paintings, popular movies, and books trace their stories...
Deities & Heros >> Celtic, Welsh, Irish & Brittish
- Description of the Bach Remedies
- Bach Flower Remedies 1. AGRIMONY (Agrimonia eupatoria) - problems hidden behind light-heartedness - This is the "Keep-smiling!" - remedy: it is for people who hide their fears, grief and worries under a mask of cheerfulness, friendliness and humor....
Homeopathy >> Bach Flower Remedies
- Tarot Cards Overview
- Tarot is made up of four suites of regular playing cards, each having 14 pieces of cards. What distinguishes a deck of tarot cards from conventional playing cards is a single card called the Fool.
Divination >> Tarot Cards
- Lachesis (Venom from the Surucucu snake)
- This remedy is made of the poison of the Surucucu,the Bushmaster, a very aggressive and poisonous snake, with the Latin name Trigonocephalus Lachesis. In many cultures the snake symbolizes the instinctive forces in us, our "beastly" and emotional...
Remedies >> Remedies L
- Pagan Mythology
- Is the traditional story presented as an historical event that serves to illustrate part of the world view of a people or explain a practice, belief, or natural phenomenon. The mythological beliefs a culture shares gives shape to its actions and choices....
Paganism & Wicca >> Holidays
- Dynamics & Bioenergetics Of OBE Sex
- Once the exit out-of-body has been mastered and projectors begin tentatively exploring their new environment, another natural barrier will soon raise its ugly head. As projectors begin expanding their horizons they will soon begin encountering other...
Astral Projection >> Out of Body Experiences
Tales Of Destiny Characters is described in multiple online sources, as addition to our editors' articles, see section below for printable documents, Tales Of Destiny Characters books and related discussion.
Suggested News Resources
- Coming Home to Roost
- Elif is fatalistic, sharp-tongued and desperate to escape her narrow destiny in the village (“That was the first time I ran away from home,” she relates. “Metallica in Plovdiv. June 11, 1999.
- Review: The Dead Lands
- Here I'm thinking of Emily St. John Mandel's Station Eleven and its troop of Shakespearean actors, how art lives on, stoking the coals of her characters' hearts, long after civilization's collapse.
- The Flame in the Flood floats comfortably in the shallows
- The Mississippi carries with it the stories of Mark Twain and William Faulkner, the verse of Langston Hughes, the sounds of the Delta blues, the steady rhythms of riverboat paddle wheels, and the ghosts of those claimed by its waters.
Great care has been taken to prepare the information on this page. Elements of the content come from factual and lexical knowledge databases, realmagick.com library and third-party sources. We appreciate your suggestions and comments on further improvements of the site.
Tales Of Destiny Characters Topics
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domain: literature


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How well do you remember the 80s?
Is your knowledge of this show toe-tapping?
Test your knowledge of the hit musical by Steven Sater and Duncan Sheik!
The flash, the panache, the showbiz flair that is Guys and Dolls can all be remembered again when you take this beginner’s quiz!
How well do you know the stage musical Cats?
Has British school teacher Mrs. Anna taught you everything you need to know about The King and I? Test your knowledge here!
See how much you know about Andrew Lloyd Webber’s rocking musical!
Ready for your own journey to the past?
Do you know what happened over at the Frankenstein place?
Test our your knowledge!
Do you think pink?
Whether you're the class clown or the valedictorian, you should be able conquer this beginner's quiz.

domain: hobby


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Sunday, March 7, 2010
Daisy is a 75% Boer x 25% Alpine doe and the sweetest goat one could have! She LOVES people and doesn't have a mean bone to her. She's bottom of the pecking order and shouldn't have to be but she's just not competitive. She's white with a heavily roaned, red cape that is hard to see. She has horns that she NEVER uses except to scratch herself with a dreamy look of enjoyment to her face. She doesn't like her horns to touch us and ALWAYS moves her head if there's even light contact with them. She passed that kindness and like of humans to her 2 doelings SHE raised last year. They are as chummy as she is and just "dolls". That was her first kidding - 2 doelings that we also adore.
Daisy was stalled (Oct 16) with a young buck (98% & caped), Maury, who was also very nice disposition wise and handsome! I can't wait to see what she produces this time! She's getting very close and is spending a LOT of time laying down. In fact the other day, hubby went in to trim on her feet and she layed with her head in his lap and fell asleep!
Daisy brought her udder and milking through the Alpine side and she has a beautiful udder for being a higher % Boer! She's bagged up, swollen behind, very loose in the ligaments and looking read to go soon. She's had a couple days of her tail looking like it's been "slimed" some so I'm thinking that was maybe her plug or she's just CLOSE.
Sorry for the crappy pics. I had to take them in the barn to get them still enough to get pics and it still wasn't easy as Daisy is a doe who's either standing up on the gate to be loved on or eating. I thought you might like to guess when Daisy will kid, what she'll have and how many. The pics are here to help you guess. She has her hair coat roughed up as she's been rubbing her horn on herself making her look rough. She's thinner over the spine this year and I'm giving her what seems to me too much grain mix. It has alfalfa pellets, black-oil sun flower seeds and beat pulp in it so they can be given more than one would like but..... Also, this is her 2nd freshening.
Leave a comment and lets see who gets what right and who's closest to her

domain: pet


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The most noteworthy decisions this month are the following:
• In In re Peabody Western Coal Company, Permit Number NN-OP-09-010 (EAB, January 25, 2013), the petitioner argued that a Clean Air Act (CAA) permit modification by the Navajo Nation Environmental Protection Agency was invalid because the CAA did not authorize the EPA to delegate permitting authority to an Indian Tribe. In denying the petition, the EAB first explained that the petitioner had not made this argument during the public comment period, as it was required to do in order to preserve the issue for purposes of a petition. Moreover, a petition to the Board was not the appropriate venue in which to test whether EPA regulations allowing permitting delegations were consistent with the CAA. There were no compelling circumstances that would justify review of the petitioner’s claim that EPA exceeded the scope of its authority under the CAA.
• In Sierra Club v. EPA, No. 10–1413 (D.C. Circuit, January 22, 2013), the EPA promulgated a rule that allowed for a de minimis exception to otherwise applicable requirements for continuous preconstruction monitoring of emissions for a period prior to the review of a permit application. The exception, according to EPA, would apply in areas where the ambient concentration of pollutants was not close to exceeding the national ambient air quality standards. The D.C. Circuit agreed with the petitioner that the Clean Air Act (CAA) authorized no de minimis exception to the monitoring requirements. The Act was unambiguously rigid in this respect. Moreover, EPA’s rationale for the exception was unpersuasive because in the absence of monitoring and the review of monitoring data, there would be no way for EPA or the public to know that an area in fact had air quality that would continue to meet applicable standards even after the additional pollutant load from planned construction projects. The D.C. Circuit thus vacated and remanded the portion of the rule establishing a de minimis exception to the requirement of preconstruction monitoring.
• In Honeywell International, Inc. v. EPA, Nos. 10–1347, 10–1350, 10–1348, 10–1349. (D.C. Circuit, January 22, 2013), the petitioners challenged the treatment of certain transfers of allowances of the air pollutant HCFC-22 made by their competitors in 2008 as permanent. The D.C. Circuit found that the petitioners had standing and that their petition was timely. However, the D.C. Circuit declined to address the merits of whether the transfers at issue should be deemed permanent because a prior panel of the D.C. Circuit had answered that question in the affirmative in Arkema Inc. v. EPA, 618 F.3d 1 (D.C.Cir.2010). A panel of the D.C. Circuit has no authority to overrule the final decision of a prior panel. Thus, the petition was denied.
• In AVX Corporation v. United States, No. 11-1697 (4th Cir. February 7. 2013), Judge Diaz, writing for the Fourth Circuit Court of Appeals, affirmed a finding that the government was not responsible for proximate site causation. The government’s expert testimony was properly included, though he was not expert in the particular TCE contamination. The lower court performed an exhaustive analysis and concluded that the government’s waste had not migrated to the site.
• In Western Wood Preservers Institute v. McHugh, Civil Action No. 12–1253 (ESH) (D. District of Columbia, February 27, 2013), trade associations challenged modifications by the United States Army Corps of Engineers to nationwide permits. The modifications prohibited certain treated wood products from being discharged into waters of the United States. The Court held that the plaintiffs lacked Article III standing because they had not shown that particular members of their organizations would be adversely affected economically by the modifications. Plaintiffs also lacked prudential standing to challenge the Corps’ alleged noncompliance with the National Environmental Policy Act (NEPA) because their organizations were not based near the affected waters and the plaintiffs’ economic concerns fell outside NEPA’s zone of interests.
• In Tennessee Gas Pipeline Co. v. Delaware Riverkeeper Network, No. 3:13–CV–46 (M.D. Pennsylvania, February 5, 2013), the Court held that the federal Natural Gas Act provides that a state environmental agency’s Clean Water Act (CWA) permits for a pipeline project must be be reviewed by the United States Court of Appeals. Because the United States Court of Appeals has the exclusive right of review, the permits could not be appealed to a state environmental hearing board and construction could not be stayed pending an appeal to that board. Continuing pipeline construction was in the public interests given the economic importance of the project and the speculative nature of the harms the defendants claimed would result from the project. The Court thus granted the emergency preliminary injunction sought by the plaintiff pipeline company.
• In Sierra Club v. Energy Future Holdings Corp., No. W–12–CV–108 (W. D. Texas, February 6, 2013), in this Clean Air Act (CAA) citizen suit regarding a power plant’s alleged non-compliance with opacity limits, the Court denied the motion to dismiss in its entirety. The Court held that the plaintiff was not required to identify specific injured members in order to establish standing as a facial matter. Nor did the Court find merit in the contention that the suit was an impermissible collateral challenge to the CAA operating permit. The suit was not rendered moot by changes in Texas law, because those changes were not approved by the EPA and hence lacked legal effect.
• In United States v. Tonawanda Coke Corp. and Mark Kamholz, No. 10–CR–219S (W.D. New York, February 22, 2013), in this criminal prosecution under the Clean Air Act (CAA), the government and defendants disagreed as to whether the defendants should be allowed to offer testimony regarding an entrapment-by-estoppel defense. The Court explained that the defense is established when a defendant can show that it reasonably and sincerely believed its conduct had been authorized, even if there was no actual authorization. The defendants had pointed to disclosures of conditions at the facility that they made to regulators that provided a sufficient ground for their developing and arguing the defense at trial. The Court prohibited testimony at trial regarding the meaning of the environmental law and legal requirements at issue, although the Court allowed testimony concerning the regulatory process, how permitting works, and other related concepts in order to educate, orient, and provide context for the jury.
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Subject: Re: [xacml] Issue: Hierarchical profile appears ambiguous and inconsistent
Thanks for the feedback. Let me try to clarify a bit.
My first objective is to understand what the spec currently says, and I am finding that the terminology is inherently ambiguous, and as a result, to me at least, that makes the details of the spec impossible to understand. So, what I did was try to disambiguate by defining "hierarchy". Let me be more explicit:
Lines 73-77 state the following:
In this Profile, a resource organized as a hierarchy may be a “tree” (a hierarchy with a single root) or a “forest” (a hierarchy with multiple roots), but the hierarchy may not have cycles. Another term for these two types of hierarchy is “Directed Acyclic Graph” or “DAG”. All such resources are called hierarchical resources in this Profile. An XML document is always structured as a “tree”. Other types of hierarchical resources, such as files in a file system that supports links, may be structured as “forests”.This is an inherently self-contradictory definition. A hierarchy has a single root. It is an "ordered set", where each entity in the set has a defined relationship to every other entity. A "forest" is not a hierarchy. It is multiple hierarchies. The "definition" above is not meaningful because it equates the singular and plural.
As a result of this self-contradiction, the spec then goes to introduce what, to me are meaningless concepts, such as lines 315-316:
Note that a node in a hierarchical resource that is not represented as an XML document MAY have multiple parents.Therefore, in order to understand what the spec says, I first found it necessary to come up with an unambiguous term for "hierarchy", which allows sentences such as the above to be restated in a "meaningful" way, such as:
Note that a node in a hierarchical resource that is not represented as an XML document MAY belong to multiple hierarchies and have a parent associated with each one.I am not saying anything so far is "wrong", simply that it is not understandable without firming up the definitions.
wrt to the "somehow identify all the hierarchies a node belongs to" comment, I was not saying it was a problem, but simply observing that that was what the spec was saying in terms of specific defn of the term "hierarchy".
Finally, I do not understand your comment that says:
Policy evaluation does not need to know anything about hierarchies that are represented with an "ancestor" attribute.I am trying to understand what policies are supposed to do with the definitions in the spec. i.e. it is the spec that says in section 3.2 that all the parent and ancestor nodes need to be assembled in the request context. What "policy evaluation" are you referring to? Are you saying what I indicated in original email that a policy does not need to know anything about hierarchies that the resource-id node does not belong to?
Daniel Engovatov wrote:


text:
At the end of Monday’s short monthly board meeting, Barnett talked to board members about posting new coronavirus guidelines on the district’s website.
While the new respiratory illness has not yet reached Tennessee, Barnett said officials are looking to be prepared.
“We had a plan ready, we thought we were going to post that today, and then one of our health supervisors who deals with health and welfare was in a meeting had some updated information,” he said. “So we’re going to try to make sure that we have the most current information. We’ll post it online tomorrow, and then our plan is to continually update that.”
Some of those district guidelines will be similar to the advice given to parents and students every flu season, according to Barnett.
“One of the things everybody needs to always remember is, of course, wash your hands,” he said, adding that parents should keep their children at home if they are showing symptoms similar to the flu or a “bad cold.”
Barnett said the system will work with parents concerning the district’s attendance policies. He said “keeping everyone safe” will be the district's main priority, and custodial staff will continue to keep schools clean.
The previously unidentified coronavirus strain is part of a family of viruses ranging from the common cold to severe acute respiratory syndrome. According to the Tennessee Department of Health, its primary symptoms are fever, coughing and shortness of breath. Symptoms usually arise between two to 14 days after exposure.
As of Monday, more than 90,000 cases have been recorded, according to a data tracking map from Johns Hopkins University. So far, there have been more than 3,000 deaths. Most cases have been in China.
In the United States, health officials have recorded 101 cases and six deaths in Washington state.
To see the district’s coronavirus guidelines, visit www.jcschools.org.


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For business applications, see
In business computer information systems, a dashboard is a type of graphical user interface which often provides at-a-glance views of key performance indicators (KPIs) relevant to a particular objective or business process. In other usage, "das ...
A dashboard (also called dash, instrument panel (IP), or fascia) is a control panel
set within the central console
A vehicle (from la, vehiculum) is a machine that transports people or cargo. Vehicles include wagons, bicycles, motor vehicles (motorcycles, cars, trucks, buses, mobility scooters for disabled people), railed vehicles (trains, trams), wat ...
An aircraft is a vehicle that is able to fly by gaining support from the air. It counters the force of gravity by using either static lift or by using the dynamic lift of an airfoil, or in a few cases the downward thrust from jet engines. ...
. Usually located directly ahead of the driver (or
An aircraft pilot or aviator is a person who controls the flight of an aircraft by operating its directional flight controls. Some other aircrew members, such as navigators or flight engineers, are also considered aviators, because they ar ...
), it displays instrumentation and controls for the vehicle's operation.
Originally, the word ''dashboard'' applied to a barrier of wood or leather fixed at the front of a horse-drawn
A carriage is a private four-wheeled vehicle for people and is most commonly horse-drawn. Second-hand private carriages were common public transport, the equivalent of modern cars used as taxis. Carriage suspensions are by leather strapping an ...
A sled, skid, sledge, or sleigh is a land vehicle that slides across a surface, usually of ice or snow. It is built with either a smooth underside or a separate body supported by two or more smooth, relatively narrow, longitudinal runners s ...
to protect the driver from mud or other debris "dashed up" (thrown up) by the horses' hooves. The first known use of the term (hyphenated as ''dash-board'', and applied to sleighs) dates from 1847. Commonly these boards did not perform any additional function other than providing a convenient handhold for ascending into the driver's seat, or a small clip with which to secure the reins when not in use.
When the first " horseless carriage
s" were constructed in the late 19th century
, with engines mounted beneath the driver such as the Daimler Stahlradwagen
, the simple dashboard was retained to protect occupants from debris thrown up by the cars' front wheels. However, as car design evolved to position the motor in front of the driver, the dashboard became a panel that protected vehicle occupants from the heat and oil of the engine. With gradually increasing mechanical complexity, this panel formed a convenient location for the placement of gauges and minor controls, and from this evolved the modern instrument panel, although retaining its
Archaic is a period of time preceding a designated classical period, or something from an older period of time that is also not found or used currently:
* List of archaeological periods
**Archaic Sumerian language, spoken between 31st - 26th cen ...
The first mass-produced automobile, the Oldsmobile Curved Dash
, got its name from its dashboard, which was curved like that of a sleigh.
Where the dashboard originally included an array of simple controls (e.g., the
A steering wheel (also called a driving wheel (UK), a hand wheel, or simply wheel) is a type of steering control in vehicles.
Steering wheels are used in most modern land vehicles, including all mass-production automobiles, buses, light and ...
) and instrumentation to show speed, fuel level and oil pressure, the modern dashboard may accommodate a broad array of gauges, and controls as well as information, climate control and entertainment systems.
Contemporary dashboards may include the
A speedometer or speed meter is a gauge that measures and displays the instantaneous speed of a vehicle. Now universally fitted to motor vehicles, they started to be available as options in the early 20th century, and as standard equipment ...
An odometer or odograph is an instrument used for measuring the distance traveled by a vehicle, such as a bicycle or car. The device may be electronic, mechanical, or a combination of the two (electromechanical). The noun derives from ancient Gr ...
, engine coolant temperature gauge, and fuel gauge
, turn indicators, gearshift position indicator, seat belt warning light, parking-brake warning light, and engine-malfunction lights. Heavy vehicles that feature air brakes
, such as trucks and buses will also have gauges to indicate the available air pressure in the braking system. Other features may include a gauge for alternator voltage, indicators for low fuel, low oil pressure, low tire pressure and faults in the airbag (SRS) systems,
A glove compartment or glove box is a compartment built into the dashboard of an automobile, located over the front-seat passenger's footwell, and often used for miscellaneous storage. The name derives from the original purpose of the compart ...
, ashtray and a cigarette lighter or power outletas well as heating and ventilation systems, lighting controls, safety systems, entertainment equipment and information systems, e.g., navigation systems
Padding and safety
Stellantis North America (officially FCA US and formerly Chrysler ()) is one of the " Big Three" automobile manufacturers in the United States, headquartered in Auburn Hills, Michigan. It is the American subsidiary of the multinational automotiv ...
Dodge is an American brand of automobiles and a division of Stellantis, based in Auburn Hills, Michigan. Dodge vehicles have historically included performance cars, and for much of its existence Dodge was Chrysler's mid-priced brand above P ...
Plymouth () is a port city and unitary authority in South West England. It is located on the south coast of Devon, approximately south-west of Exeter and south-west of London. It is bordered by Cornwall to the west and south-west.
cars came with a safety dashboard that was flat, raised above knee height, and had all the controls mounted flush.
Padded dashboards were advocated in the 1930s by
Automotive safety is the study and practice of design, construction, equipment and regulation to minimize the occurrence and consequences of traffic collisions involving motor vehicles. Road traffic safety more broadly includes roadway design ...
pioneer Claire L. Straith
. In 1948, the Tucker 48
became the first car with a padded dashboard.
One of the safety enhancements of the 1970s was the widespread adoption of padded dashboards. The padding is commonly
Polyurethane (; often abbreviated PUR and PU) refers to a class of polymers composed of organic units joined by carbamate (urethane) links. In contrast to other common polymers such as polyethylene and polystyrene, polyurethane is produced from ... foam
Foams are materials formed by trapping pockets of gas in a liquid or solid.
A bath sponge and the head on a glass of beer are examples of foams. In most foams, the volume of gas is large, with thin films of liquid or solid separating the r ...
, while the surface is commonly either polyvinyl chloride
(PVC) or leather in the case of luxury models.
In the early and mid-1990s,
An airbag is a vehicle occupant-restraint system using a bag designed to inflate extremely quickly, then quickly deflate during a collision. It consists of the airbag cushion, a flexible fabric bag, an inflation module, and an impact sensor. Th ...
s became a standard feature of steering wheels and dashboards.
Fashion in instrumentation
In the 1940s through the 1960s, American car manufacturers and their imitators designed aesthetically shaped instruments on a dashboard accented with chrome and transparent plastic, which could be less readable, but was often thought to be more stylish. Sunlight could cause a bright glare on the chrome, particularly for a convertible. On North American vehicles in particular, this trend lingered on until the late-1980s, which still featured dashboards with wood and fake chrome embellishment along with square instruments - long after European and Japanese manufacturers had long embraced a plainer, more functional and austere approach for dashboard and instrument panel design.
With the advent of the VFD
A light-emitting diode (LED) is a semiconductor device that emits light when current flows through it. Electrons in the semiconductor recombine with electron holes, releasing energy in the form of photons. The color of the light (cor ...
in consumer electronics, some manufacturers used instruments with digital readouts to make their cars appear more up to date. Some cars use a
A head-up display, or heads-up display, also known as a HUD (), is any transparent display that presents data without requiring users to look away from their usual viewpoints. The origin of the name stems from a pilot being able to view informa ...
to project the speed of the car onto the windscreen in imitation of fighter aircraft, but in a far less complex display.
In recent years, spurred on by the growing aftermarket use of dash kits, many automakers have taken the initiative to add more stylistic elements to their dashboards. One prominent example of this is the Chevrolet Sonic which offers both exterior (e.g., a custom graphics package) and interior cosmetic upgrades.
In addition to OEM dashboard trim and upgrades a number of companies offer domed polyurethane or vinyl applique dash trim accent kits or "dash kits".
Manufacturers such as BMW
is a Japanese Public company, public multinational corporation, multinational Conglomerate (company), conglomerate manufacturer of automobiles, motorcycles, and power equipment, headquartered in Minato, Tokyo, Japan.
Honda has been the world ...
is a Japanese multinational automotive manufacturer headquartered in Toyota City, Aichi, Japan. It was founded by Kiichiro Toyoda and incorporated on . Toyota is one of the largest automobile manufacturers in the world, producing about 10 ...
Mercedes-Benz (), commonly referred to as Mercedes and sometimes as Benz, is a German luxury and commercial vehicle automotive brand established in 1926. Mercedes-Benz AG (a Mercedes-Benz Group subsidiary established in 2019) is headquartere ...
have included fuel-economy gauges in some instrument clusters, showing fuel mileage in real time, which was limited mainly to luxury vehicles and later, hybrids. Following a focus on increasing fuel economy in the late 2000s along with increased technology, most vehicles in the 2010s now come with either real-time or average mileage readouts on their dashboards. The
An ammeter (abbreviation of ''Ampere meter'') is an instrument used to measure the current in a circuit. Electric currents are measured in amperes (A), hence the name. For direct measurement, the ammeter is connected in series with the circuit ...
was the gauge of choice for monitoring the state of the charging system until the 1970s. Later it was replaced by the
A voltmeter is an instrument used for measuring electric potential difference between two points in an electric circuit. It is connected in parallel. It usually has a high resistance so that it takes negligible current from the circuit.
. Today most family vehicles have warning lights instead of voltmeters or oil pressure gauges in their dashboard instrument clusters, though sports cars often have proper gauges for performance purposes and driver appeasement along with larger trucks, mainly to monitor system function during heavy usage such as towing or off-road usage.
* Air core gauge
A binnacle is a waist-high case or stand on the deck of a ship, generally mounted in front of the helmsman, in which navigational instruments are placed for easy and quick reference as well as to protect the delicate instruments. Its traditional ...
Vehicle audio is equipment installed in a car or other vehicle to provide in-car entertainment and information for the vehicle occupants. Until the 1950s it consisted of a simple AM radio. Additions since then have included FM radio (1952), 8- ...
A carputer, or car-puter, is a computer with specializations to run in a car, such as compact size, low power requirement, and some customized components. The computing hardware is typically based on standard PCs or mobile devices. They normally ha ...
* Control panel
* Control stand
* Electronic instrument cluster
* Flight instruments
* GM Instrument Cluster Settlement
An automotive head unit, sometimes called the infotainment system, is a component providing a unified hardware interface for the system, including screens, buttons and system controls for numerous integrated information and entertainment func ...
* In car entertainment
* Vehicular communication systems
Dashboard head units


Senator Markey (D-MA) has introduced a new bill that would install fingerprint technology on all new guns. The "Handgun Trigger Safety Act" would make it so that only the owner of a gun could discharge it, the argument being that this would reduce accidental death and deaths by stolen guns. The bill also asks for $10 million towards gun violence research.
A Student Wanted A Conversation On Religious Freedom; She Got A Petition Against Her Instead | Matt Vespa
Grassley to Holder: Why Is The VA Putting So Many Veterans on Your Federal Gun Ban List? | Katie Pavlich


text:
The Last Adventure
Autor: Edgar Wallace
Edgar Wallace was a prolific author of crime. adventure and humorous stories. whose best known creations include „The Four Just Men”. „Sanders of the River”. and „J. G. Reeder”. Although Wallace wrote many „stand alone” novels it is. perhaps. for his series based material always popular with readers that he remains best known. „The Last Adventure” is a story packed with intrigue. treachery. assassinations. and machinations. and it highlights Wallace’s unmatched skill in setting a pulse-pounding pace. As the novel is rather short and quite fast-paced with a lot of scenery-changes and adventures. this nice. Edgar Wallace provides a thrill of another sort!
The Amazing Judgment
Autor: E. Phillips Oppenheim
This is a very early novel by E. Phillips Oppenheim from 1897. The wealthy and bored Lord Hildyard. Marquis of Esholt. is on a yachting tour with a group of friends. including his kept lover. Pauline Owston. When Hildyard spies an apparently uninhabited island. he slips off the ship in search of adventure. In the middle of the night. he hears wonderful violin music and finds a young and beautiful girl. Bertha. playing in the forest. She is accompanied by a cruel and misshapen dwarf. Enchanted. Hildyard stays on the island. where he finds an old college chum. Stanley Owston. the estranged husband of the actress. who is the guardian of the girl. and the owner of the island. The adventures are continuing…
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