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NOVO NORDISK POSTDOCTORAL RESEARCH FELLOW
I completed my PhD in Cardiac Physiology at the University of Otago (Dunedin, New Zealand) under the supervision of Dr Jeff Erickson, Dr Regis Lamberts and Associate Professor Fiona McDonald. During my PhD, I investigated the role of calcium calmodulin dependent protein kinase (CaMKII) in the progression of diabetic heart disease and provided evidence of a novel therapeutic potential for CaMKII inhibition to reverse impaired contractility and prevent heart failure progression in diabetic patients. I then moved onto my initial post-doctoral position at the University of Auckland (NZ) under the supervision of Dr Kim Mellor, further developing my research experience into cardiac metabolic dysregulation in diabetic cardiomyopathy.
I was awarded a Novo Nordisk Postdoctoral Research Fellowship to work with Professor David Ray in OCDEM and Dr Maxwell Ruby at the Novo Nordisk Research Centre Oxford, starting in January 2020. The focus of my fellowship is to investigate circadian regulation of liver energy metabolism in diabetes. This project will capitalise on recent innovations which permit human liver organoids to be used as a translational model for diabetes and metabolic dysfunction. I will utilise high throughput ‘omics technology platforms, cell based assays and systems microscopy to allow entirely novel biology to be revealed and provide potential therapeutic advances.
Glycogen-autophagy: Molecular machinery and cellular mechanisms of glycophagy.
Koutsifeli P. et al, (2022), J Biol Chem, 298
Elevated myocardial fructose and sorbitol levels are associated with diastolic dysfunction in diabetic patients, and cardiomyocyte lipid inclusions in vitro
Daniels LJ. et al, (2021), Nutrition & Diabetes, 11
Fructose Metabolism and Cardiac Metabolic Stress.
Annandale M. et al, (2021), Front Pharmacol, 12

domain: biology


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WASHINGTON - The Roman Catholic-Reformed Ecumenical Dialogue in the United States has announced three important new developments in its ongoing ecumenical discussion. The U.S. Conference of Catholic Bishops (USCCB), through its Committee for Ecumenical and Interreligious Affairs is a participant along with the Presbyterian Church (USA), the Reformed Church in America, the United Church of Christ, and the Christian Reformed Church in North America. The first round of this Reformed-Roman Catholic dialogue began soon after the Second Vatican Council (1962-65), which opened the door for ecumenical discussions.
In this latest development the USCCB and each of the Reformed Churches participating in the dialogue are making the documents from the previous two rounds of dialogue publicly available. These documents focus on Baptism, the Eucharist or Lord’s Supper, and the Church.
- These Living Waters (2003-07, focusing on Baptism)
- This Bread of Life (2007-10, focusing on the Eucharist/Lord’s Supper)
- The One Body of Christ (2012-19, focusing on ministry and authority in the Church).
Of particular note, These Living Waters resulted in a “Common Agreement on Mutual Recognition of Baptism,” that Reformed Christians and Catholics recognize one another’s validly administered baptisms.
Two members of the previous two rounds of the dialogue, Fr. Dennis Tamburello of Siena College in Loudonville, New York, and Dr. Ronald J. Feenstra of Calvin Theological Seminary in Grand Rapids, Michigan, are preparing a study guide based on the documents from those two rounds. This study guide, tentatively entitled Learning from One Another: A Study Guide for Reformed-Roman Catholic Dialogue, is intended for use in local ecumenical discussions.
The dialogue will begin a new round of discussion on the topic of justification and justice, commencing with a meeting to be held in Chicago in 2022.

domain: library


PLEASANTVILLE, N.Y. – A burglary at a home on King Street in Pleasantville was interrupted Thursday morning when the suspect realized a woman living there was in the house, Mount Pleasant Police said.
Police Chief Louis Alagno said that around 11:40 a.m. a man described as a light-skinned black male wearing a red, hooded sweatshirt entered the house through a back door. No further description of the suspect was available but Alagno said the man fled the house and entered a black Nissan Altima before leaving the property.
Police say that no items were taken from the home. The incident is still under investigation.
- 1 Dad Looks To Reduce Charges In Fatal Crash Involving Pleasantville Girl
- 2 July 4 Terror Warning Issued By Homeland Security, FBI
- 3 Police Shoot, Kill Fugitive Richard Matt; Fellow Escapee David Sweat On Run
- 4 Second Escapee David Sweat Shot By New York State Police, Now In Hospital
- 5 Men Shot, Killed Before Hutchinson River Parkway Crash ID'd


The lads at Vitamin Gum filmed this fantastic vision of the Solar Eclipse as viewed from Auckland, and have shared it with the nzherald.co.nz readers.
Latest NZH Video
Authorities in Tennessee say one person is dead and seven people sustained injuries after a gunman opened fire at a church in Nashville. Source: AP
Former New Zealand First MP Richard Prosser talks to Chris Lynch about Winston Peters.


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What Does The Waka Waka In Shakiras Song Mean – The worst anthem of the World Cup? In a genre known for its bad songs, Shakira’s “Waka Waka” is awesome.
Here in a country that still calls it football, we cannot fully appreciate the magnitude of the World Cup. But if there’s one thing we Americans can say we invented, it’s the retro pop song. So as we celebrate the biggest football event in the world and the fact that we’re hosting it in South Africa for the first time, we take a look at an unfortunate side effect of the World Cup. Let’s take a moment: the World Cup song.
What Does The Waka Waka In Shakiras Song Mean
What can you say about the genre that brings Ian McCulloch and the Spice Girls together? A musical form that managed to create one of the scariest anthems on this year’s star-studded official album?
Waka Waka(this Time For Africa) Shakira Lyrics
We know that the world is huge out there and that it must be difficult to create anthems that somehow reflect global musical sensibilities and sportsmanship. But have some mercy. Our ears are bleeding. And Ke$ha suddenly looks better and better.
But it’s not all pain; There are some advantages. Don’t think we’ve drunk too much hate, we’ll leave you with the World Cup line-up that did everything right on the first day of competition – with Angelica Cudgio, Bono, John Legend, Bill T. Jones, dude! Dancers and Curtis Mayfield Classics.
Mary Elizabeth Williams is senior writer and author of The Disasters and Miracles series. Shakira was invited to the opening ceremony of the World Cup for the fourth time, confirming her status as the undisputed queen of the World Cup. . The opening ceremony will take place this year on November 20th at the Al-Bait Stadium before the opening match between Ecuador and the local team Qatar.
As always, the artists responsible for the event will give a live presentation and perform the official song of the World Cup. The official song of the 2022 World Cup in Qatar is “Hiya Haya (Better Together)” and is sung by Trinidad Cardona, Davido and Ayesha.
Between Bts Jungkook ‘dreamers’ & Shakira ‘waka Waka’ We Came A Long Way With Fifa
It was released seven months ago, but despite the organization’s tireless efforts to promote the song, it wasn’t a huge success: only 27 million YouTube views and half of the comments called for Shakira’s acclaimed “Waka Waka.”
Shakira’s decision to host the show was confirmed hours earlier, much to the delight of football fans.
This will be Shakira’s fourth appearance at the event, following performances in Germany in 2006, South Africa in 2010 and Brazil in 2014.
Colombia released two World Cup songs, “Waka Waka”, the official song in 2010, and “LA LA LA” in 2014, which, although not the official World Cup song, was a crowd favorite and was performed instead of the official song . It is speculated that she will sing both songs on the release and will be joined by Maluma from Colombia, Nicki Minaj from the Caribbean and Jungkook from BTS.
Waka Waka (shakira) » Choir Cd
He has been news editor at Music Mundial since 2019. He has a degree in journalism from the Central University of Venezuela and has a passion for music. The chorus of Shakira’s Waka Waka was taken verbatim by the Cameroonian group Golden Sounds, Zingaliwa, who performed it in the ’80s and ’90s (pictured) -)
While Insta Reels (and TikTok abroad) has featured some songs with junk mixes or remixes, it has also become a gateway to discovering some underrated classical music. One final example
Is completely taken over from it. The Colombian singer’s reworked version served as the official song for the 2010 FIFA World Cup in South Africa. However, neither Shakira’s record company nor FIFA compensated the Cameroonian artists for the use of the lyrics and compositions.
A decade later, the original is still unexpectedly trending on Reels and TikTok and is often used in dog videos, football moments or just a few funny memes.
From Light The Sky To Waka Waka: Here Are Some Of The Most Memorable Fifa World Cup Songs
Who wrote the original? The song was originally written and performed by a group from Cameroon called Golden Sounds.
After the immense popularity of the song). The composition of the members is quite funny as they served in the Presidential Guard of Cameroon when the organization was founded in 1984.
The members had military experience, having served in the Cameroonian army during World War II, when France ruled the African country.
Golden Sounds (later Zingaliwa) was founded by the Cameroon Presidential Guard, although civilian members were later added (Photo – Latest FM)
Losing My Virginity To Shakira’s Waka Waka
After launching their music project, the members of Golden Sounds put on a comedy show at every performance. They usually wore military uniforms and had pillows stuffed under them and around their stomachs. Why so?
Funnily enough, military men often found themselves sitting on trains when their bloated bellies ate too much government food.
Their videos can still be found in the hidden corners of YouTube, but the video quality is pixelated. Although the other members are unknown, the group’s lead singer, Jean-Paul Z. Bella, continued to serve in the Presidential Guard, which he left in 2002 after 30 years of service.
Track structure and meaning: An instantly catchy track, the original version is 11 minutes long.
English Worksheets: Shakira´s Song Waka Waka
It belongs to the Cameroonian urban music genre Makosa. The genre grew out of funk, disco and even Christian hymns and was a huge hit in Cameroon in the 1980s. Songs like
Should have been a dance hit. Finally, the word “mukosa” means “dance” in the Cameroonian Douala language.
The text is called Pidgin English and contains elements of French, Jamaican patois and West African English dialects.
There are various interpretations of what the title means. Although it seems catchy on the surface, one school of thought holds that the song captures the loneliness and struggle of soldiers serving in World War II (similar to Bob Marley’s reggae hits).
Lirik Lagu Waka Waka Shakira
But in the video, the members are dressed like European soldiers in Africa, complete with short hair and white mustaches. This led some music critics to conclude that the song was a satire of African soldiers who exploited their European masters and oppressed their own people.
The group’s intentions are unclear as its members served in Cameroon’s colonial army. What is clear, however, is that the song is no longer used today, as it is regularly played at military and police parades in independent Cameroon. The locals took it back.
It also became a popular hit in Colombia. When DJs in South America became more and more fond of African songs in the 90s and remixed them,
“Golden Sounds” took time out for “Waka Waka”: In a 2010 Associated Press video, Shakira was seen telling reporters that the song’s opening lines and pre-chorus “that came to be.” However, he never once mentioned the motivation behind the course.
Shakira Responded To Princess Charlotte Over Love Of
A 2013 article in the Cameroon-based literary magazine Bukwa claimed that intellectual property from African countries was apparently copied without crediting the original artists. The article has been added.
For example, the author describes how Ze Bella, the singer of the group “Golden Sounds”, was informed.
Although he was happy that the global music icon remixed his song, he regrets that Sony Music didn’t pay him the compensation he deserved.
We are truly helpless to go to America and demand our rights. There are at least 30 groups who have recreated the Zingaliwa…
Shakira Presents The New Mango Solidarity T Shirt Collection Inspired By The Official World Cup Song ‘waka Waka’ Madrid, Spain Stock Photo
In 2010, before the intellectual property dispute escalated, the group told local media that discussions were ongoing and the matter had been settled out of court. But her manager, Didier Ado, is Shakira’s manager and added that negotiating with Sony was a difficult task. in me.
FIFA eventually released a statement saying: “The song was written by world-famous Latin American singer Shakira…The chorus is similar to the lyrics of a famous song from Cameroon, particularly by Golden Voices, known as.”
Zangaléwa is not the only Cameroonian hit to influence global pop. From James Brown to Michael Jackson, Timbaland and Missy Elliott, all of these artists have borrowed from Cameroonian singers largely unknown on the world music scene.
As an example. The song is perhaps best known for its outro, “Ma-mako, ma-ma-sa, mako-makosa” (later covered by Rihanna in 2013).
Video: ‘waka Waka’, The Official 2010 World Cup Song, By Shakira
). Many may think that this is an unnecessary waste, but this line is actually a continuation of the word Makossa and is actually derived from this word.
What happened to Golden Sounds and Manu could have happened to many artists in Africa.

domain: artistic


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The definitive, glorious (and musical) story of how the Hebrew song Hava Nagila (Let Us Rejoice), set to a traditional melody from the Ukraine, became the signature theme of Jewish life. Despite having become truly universal in appeal, the song never lost either its Jewish soul or origin. Features interviews with Harry Belafonte, Leonard Nimoy, Connie Francis, and Glen Campbell, as well as performances of the song by Belafonte, Francis, Danny Kaye, Bob Dylan, Lena Horne, Regina Spektor and Chubby Checker. Plan to walk out humming--or maybe singing out loud--this very special and universally appealing melody.
- Director: Roberta Grossman
- Country: USA | Ukraine | Israel
- Genre: Documentary | Comedy | History | Music
- Year: 2013
- Run Time: 01:12:59
- imdb Score: 0.0/10 (0 votes)
- Language: English
- Rating: Not Rated
- Cast: Harry Belafonte, Glen Campbell and Connie Francis
Garry Goldstein - LOS ANGELES TIMES
"Grossman finds lively, often passionate and funny interpreters - among them rabbis, historians, musicologists and klezmer musicians - to guide us through the song's many transformations. "
Ella Taylor - NPR
"A toe-tapping, entertaining celebration of the song, starring Harry Belafonte, Connie Francis, Glen Campbell, Leonard Nimoy and many others."
- SAN FRANCISCO CHRONICLE
Miami Jewish Film Festival 2013
Washington DC Jewish Film Festival 2013
San Francisco Jewish Film Festival 2012
Boston Jewish Film Festival 2012


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It's very seldom that I go to Starbucks now. If you follow this blog, you'd know that I've been frequenting other cafes when I go out. But when I had my "Me" time yesterday, I decided to reunite with my favourite seasonal beverage "Toffee Nut Latte". Drinking this helps me feel the Christmas spirit and somehow brings me to happy memories from my other home, Manila.The Starbucks I used to frequent had a new set of staff. I was kind of sad and missed my old barista but the new one was good as well. He made my Toffee Nut Latte perfectly sweet (no need to add sugar).
A few musings while I was enjoying my cuppa:
Starbucks coffee is really expensive. My tall latte with whipped cream cost me about $5.30. Most cafes here charge less and taste better. I find more value buying their coffee beans and making coffee the way I like it.
Husband and I unconsciously choose to have coffee at home since we've had the Nespresso. And because of that we are saving money. How? We save on petrol, we save on time going out, we save on money because we are not tempted to buy things we don't need when we're out and most of all, the Nespresso coffee pods are cheap (a coffee pod costs between 68cents-70cents) and yet we get great quality coffee.
Drinking coffee in the Philippines is expensive. Yes while having coffee, I thought of how expensive it is to maintain a "coffee lifestyle" in the Phils. Wala lang, naisip ko lang. Let's not do the converting of dollars to peso because that's not the point. I just have this comparison. The money you pay to buy a tall latte in the Philippines is equivalent to a few train rides in the MRT; while in Australia, a tall latte is equivalent to one train ride. Also, we can find a good cup of coffee in Australia from AUD$2.70 to $3.50. The Phils has cheaper alternatives but in general it still seems expensive to me. While drinking coffee (in cafes) in Australia is likened to a basic commodity, drinking coffee (in cafes) in the Phils seems like a luxury.
So there, just a few idle thoughts of mine yesterday. Have a lovely day today!

domain: finance


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November 1, 2021
Telecoms.com periodically invites expert third parties to share their views on the industry’s most pressing issues. In this piece Wim van Thillo, CEO and Co-Founder at Pharrowtech, talks up the merits of fixed wireless access for connecting the unconnected.
To be part of the world’s ever-more digital economy, individuals and businesses need reliable, high speed internet access. The latest smartphone or tablet might be a great gadget, but without connectivity it won’t have a significant impact on anyone’s life.
World organisations and national governments across the globe know this, and work with the private sector to improve access to gigabit broadband. Indeed, UNESCO and the ITU Broadband Commission for Sustainable Development have set a target of connecting 75% of the world’s population to high-speed internet by 2025. To reach this ambitious, but not impossible, target, developing countries will need to be an area of focus.
One of the regions with the lowest access to high-speed internet is Sub-Saharan Africa, where only 29% of the population use the internet at all, much less gigabit broadband. This is compared to 57% of the world’s population, and 86% of those in Europe and Central Asia.
The difference in these figures is striking, and has a negative economic impact on Sub-Saharan Africa – a region which contains many of the least developed countries in the world. Widespread, reliable, high speed connectivity is vital to support economic growth and development. Without it, the region simply won’t have access to the same opportunities that others do.
So the question is, how do we solve this challenge?
The Fibre Failure
There is no doubt that European fibre deployments in densely populated, urban areas have generally been successful. That said, it is simply not an approach that could be replicated in Sub-Saharan Africa, for several reasons.
First, Sub-Saharan Africa does not have legacy internet infrastructure that can be upgraded. While there are advantages to a blank connectivity landscape, such as enabling the design and deployment of next-generation and even futureproof networks, the obvious downside is a lack of hardware in place that can be upgraded, such as pipes for underground cabling.
This links to the second challenge, which is the extremely high cost of fibre deployments. This is of course exacerbated if there is no existing infrastructure in place, and is one of the primary reasons why global fibre deployments to date have been largely centered in densely populated cities.
Third are environmental considerations. Fibre is disruptive to deploy, due to the need for laying cables underground that reach individual homes and businesses. This can be extremely disruptive and may have a negative impact on the natural environment. Furthermore, fibre is not particularly well suited to deployments in areas with challenging topography such as mountains, valleys and rivers.
Fundamentally, fibre is not a panacea for the world’s connectivity challenges. Satellite internet has also been proposed as a way to bring Sub-Saharan Africa online, but due to its low throughput and high latency, this is not a feasible long-term solution.
A Silver Bullet
One technology that could be the solution for many, if not all, of these challenges is Fixed Wireless Access (FWA). As little as five years ago this suggestion might have been dismissed, but the technology has evolved in leaps and bounds and is now a highly attractive option.
Most notably, not only can FWA now provide connectivity at a comparable bandwidth and latency to fibre, but it can be deployed rapidly and at a far lower cost, as no large-scale physical infrastructure is required. This also means that any environmental impact is significantly less than that of deploying fibre.
Furthermore, FWA can utilise unlicensed 5G frequency bands for connectivity. Indeed, one of the key reasons that FWA is now a viable alternative to fibre internet is 5G. The ability to use unlicensed bands lowers the barrier to participation for ISPs, and so can increase market competition, helping keep costs low for consumers – crucial in developing economies.
While 4G connectivity is appropriate for a myriad of mobile and smartphone use cases, it is not suitable for reliable streaming, video conferencing, or other high-bandwidth tasks. 5G is; it is far more than the next iteration of mobile connectivity. It will transform the way that individuals globally live and work. 5G and FWA in combination will be the silver bullet for connecting everyone, everywhere, to high speed internet.
To A More Connected World
Specific problems need specific solutions, and Sub-Saharan Africa’s connectivity challenges cannot be solved with a European approach. While urban fibre deployments in Western Europe have brought gigabit broadband to many for the first time, it is simply not the best tool to give that same access to high-speed connectivity to African citizens.
FWA and 5G, deployed in combination, are that specific solution for deploying fast and reliable internet at a low cost across challenging terrain – and supporting Sub-Saharan Africa’s economic development.
Wim has more than 15 years of experience focused on mmWave R&D first as a researcher and later as a program director for imec’s activities in cellular, WiFi and mmWave transceivers. In that role, he was essential in shaping the R&D roadmap and business opportunities for emerging wireless technologies. Wim was also a visiting researcher at UC Berkeley, focused on researching 60GHz high speed wireless communications. He holds a PhD in Electrical Engineering and a degree in Business Economics from the Katholieke Universiteit Leuven.
Read more about:Discussion
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domain: geography


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On Monday, Microsoft announced some changes to licensing with respect to VDI, as described in yesterday’s article, Microsoft Changes Windows Licensing. Although Microsoft licensing has always been somewhat complex and difficult to understand, this change is a step forward in terms of simplification. Further, the announcement certainly was good news for enterprises that use VDI, because now simplified per-user licensing can be applied. But only for enterprises!
What galvanized Microsoft to make this change? Microsoft has been steadily losing its share of the workstation market, especially with the reduced acceptance of Windows 8.x. Within most enterprises, Apple user devices are at least as common as Windows-based workstations, and that directly translates to fewer dollars in Microsoft’s pocket for desktop OS licenses. This licensing change makes it advantageous for IT organizations to rethink the platform selection for user device purchases, especially where VDI is in use.
Strategically, this is a smart move on Microsoft’s part in its quest to increase its share of the workstation market, especially with the upcoming release of Windows 10. Although Windows 10 isn’t scheduled to be released until later in 2015, enterprises are immersed in 2015 strategic and business planning right now; the timing for this announcement could not have been more precise.
Service providers offering Desktop as a Service (DaaS) must still use Windows Server–based licensing for their virtual desktop products; nothing has changed for this segment of the market. The DaaS requirements within the Microsoft Services Provider License Agreement (SPLA) are still the same, and it appears that Microsoft has no intention of budging from this stance. From Microsoft’s perspective, it has a captive audience that is paying a premium in order to offer DaaS, and there’s no viable alternative (yet!), so there is no incentive for modification.
Outsourced DaaS makes strategic sense for the small and midsized business (SMB) market in particular. Companies in this size range don’t have the time, money, or expertise to support IT infrastructure in-house, so they have been forced to pay for server-based DaaS—but that has changed slightly now as well. With Microsoft’s announcement of the Enterprise Cloud Suite, per-user pricing is available only under Microsoft’s cloud offering.
One caveat with regard to ECS is that the organization must have 250 or more users. A few if/then statements are incorporated into the logic of the per-user ECS licensing, but the bottom line is that enterprises with fewer than 250 users will now be relegated to serving as the prime market for independent service providers. Conveniently, this enables Microsoft to attract the larger piece of the SMB market and leave the smaller section to service providers.
For service providers, the time and effort associated with transitioning clients from in-house operations to cloud/hosted environments is significant. Because service providers typically base their pricing on the number of users and spread the initial setup costs accordingly, this means that the higher per-user setup fees for migrating smaller enterprises makes DaaS more expensive.
All in all, the new per-user pricing from Microsoft is good news for enterprises but not for service providers. Last week, VMware announced that it was developing VDI for Linux. If service providers have a Microsoft alternative for DaaS, the SMB market for cloud/hosted providers will get very interesting!

domain: news


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I started as an intern and have run the gamut as far as being part of NJ101.5 and our sister station, 105.7 The Hawk. I've been a producer, as well as an on-air voice. I'm now the producer for the Bill Spadea Show, as well host of the Saturday Night Slaughterhouse on the Hawk, and mos recently, I'm now the co-host of the New 'Jersey' Guys sports podcast.
Top 10 Funniest Christmas Movies
Don't feel like grabbing the box of tissues this year to watch 'It's a Wonderful Life'? Want to lighten it up this season when you sit down with the family to watch a Christmas movie? Well then we have the ultimate list of fun Christmas movies for you!
Scott Weiland’s Best Songs: The Essential Playlist
Scott Weiland's careers spanned over 2 decades with Stone Temple Pilots, Velvet Revolver and a solo career. Here is Weiland's essential playlist.
‘Slayer Bob’ reveals new heavy metal Christmas light displays with Slipknot and Disturbed
Slayer Bob, the mastermind behind such heavy metal Christmas displays like Slayer and Metallica has returned this year with new displays including Slipknot and Disturbed.
Horror Movies That Rock for Halloween [VIDEOS]
Rock music and Halloween are almost the perfect compliment to each other. Acts like Alice Cooper, Marilyn Manson, Kiss, Twisted Sister and W.A.S.P. used horror theatrics in their shows to give their fans a visual element to go along with their already killer sounding concerts...
Top 20 horror movies for Halloween
Looking to scream this Halloween? Looking to put some fright in your night? Then look no further than right here as we've compiled a list of the 20 scariest horror movies
Metalhead Puts on Air Drumming Display for the Ages (Video)
Watch as this headbanger performs a wicked air drum solo while on the New York City Subway.
The top movies to celebrate Pope Francis’ visit to Philly
Pope Francis has arrived in the area and will be visiting Philadelphia this weekend. While being part of the pilgrimage to the City of Brotherly Love to see the pope may not be for you, there are other ways to get into the spirit of the weekend.
A Heavy Metal Playlist to Celebrate Pope Francis’ Arrival in Philly
I know what you're thinking. Pope Francis and heavy metal music? Yep! That's exactly what creating this entire playlist was about.
Hilarious Vine recreates Rocky’s run through Philly with Pope Francis (Watch)
Pope Francis is in Philly this weekend and someone who found a way to tie in Pope Francis' visit to the city's favorite son, Sylvester Stallone as Rocky Balboa.
Iron Maiden Unveil New Video for ‘Speed of Light’
Iron Maiden fans it is time to get excited!
Drummer Brian Tichy’s Amazing Speed Bag Tribute to Rush
This is reason # 1,001 why drummers rule. Drummer Brian Tichy has probably pulled off one of the coolest and unique tributes to one of my all-time favorite bands, Rush.
5 Great Movies to Watch on the 4th of July
Maybe you aren't into celebrating Independence Day on the the beach and you don't feel like fighting to the traffic to travel to a barbeque. If you're a movie fan, maybe it's time to enjoy the long weekend just sitting on the couch with family and friends and watch some movies th…

domain: entertainment


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From the star of No Reservations, Anthony Bourdain's New York Times-bestselling chronicle of travelling the world in search the globe's greatest cuilnary adventures
"Bourdain shows himself to be one of the country's best food writers. His opinions are as strong as his language, and his tastes as infectious as his joy." -Sam Sifton, New York Times Book Review
The only thing "gonzo gastronome" and internationally bestselling author Anthony Bourdain loves as much as cooking is traveling. Inspired by the question, "What would be the perfect meal?," Tony sets out on a quest for his culinary holy grail, and in the process turns the notion of "perfection" inside out. From California to Cambodia, A Cooks' Tour chronicles the unpredictable adventures of America's boldest and bravest chef.
Fans of Bourdain will find much to love in revisting this classic culinary and travel memoir.
About the Author
Anthony Bourdain was the author of the novels Bone in the Throat and Gone Bamboo, the memoir A Cook’s Tour, and the New York Times bestsellers Kitchen Confidential, Medium Raw, and Appetites. His work appeared in the New York Times and The New Yorker. He was the host of the popular television shows No Reservations and Parts Unknown. Bourdain died in June 2018.
Food Writer of the Year — Bon Appétit
“[Bourdain] is a one-man army traveling the world on his stomach--and his droll wit.” — People
“None of your limp-wristed, pinch-mouthed, hoity-toity delicacies for this guy.” — Elle
“Bourdain’s mission is to show the cool, un-Martha side of the culinary world.” — Time magazine
“Mighty engaging.... [Bourdain’s] snappy, full-bore writing style--whether being sarcastic, passionate, or descriptive--is good entertainment.” — Kirkus Reviews
“Adventurous and opinionated, [Bourdain] is very good company.” — Milwaukee Journal Sentinel
“Brilliant. A chain-smoking, hard-drinking, cut-to-the-chase guy’s guy, ready to try anything new and different.” — Minneapolis Star Tribune
“Some fine food adventure reading…. Bourdain offers excellent insight into real food.” — San Francisco Chronicle
“If you’re looking for a camel ride and an amiable companion, you could do a lot worse.” — Washington Post
“Vintage Bourdain.” — Dallas Morning News


Rutgers has been in complete turmoil since suffering their first loss in week 4. After losing to three straight ranked, Big Ten opponents (which are all now in the top seven of the USA TODAY Sports AFCA Coaches Poll, by the way), Rutgers dropped a fourth straight against Northwestern.
The Illinois Fighting Illini may not be the strongest team in the Big Ten, but they are coming off of a huge victory against No. 17 Penn State in a game that took nine overtimes.
ESPN FPI has the Scarlet Knights favored in this road matchup. Let’s take a look at the betting lines. All Betting Lines are Courtesy of Tipico Sportsbook:
The Scarlet Knights are favored, giving one and a half points (-1.5) to the Fighting Illini. The Over/Under is set at 41.5 (-110).
Illinois may have beaten a strong team in Penn State, but putting the victory solely on the play of Illinois would be misleading. After that many overtimes, the final score was 20-18. The Nittany Lions were playing short-handed and it showed through the contest.
Rutgers is coming off the bye week, so they have had plenty of time to prepare for the suddenly hot Illinois. The Scarlet Knights sit at 3-4 on the season. If they want to gain some ground in the Big Ten and continue to trek towards bowl eligibility, they will need to take care of business this weekend.
Want to have a little fun this weekend? Play for free in the Week 9 Rutgers-Illinois Challenge. Answer six questions…plus a tiebreaker correctly for your chance at winning a gift card through Daily Ticket, powered by Tipico Sportsbook.


Pragmatic Industrial Automation Solutions Pvt. Ltd. is a solution provider which is involved in the automation system integration program. Solution provided by us are proven and trusted and help in implementation and project management of industrial automation and process control solutions.
PRAGMATIC OFFERS WIDE RANGE OF COST EFFECTIVE ENGINEERING SERVICES.
Pragmatic provides complete training on logical controllers, panel designing, PLC, speed drivers and more. Our innovative products are used in the most demanding applications. The use of latest production methods helped us in developing new range of products in a cost-effective manner.


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Horseback riding can be difficult for a novice to learn about shapes, track conditions and what jockey is doing well at the moment. For those who are looking to get your leg here is a list of ten best books to help you improve your racing skills. This list is completely subjective and viewing the best books will be different. I invite you to publish other books that you may find privileged to the other members.
1. Handicapping 101: Horseback riding, Brad Free (2007)
Working in races does not mean you need advanced IQ, but only you have basic knowledge of racing – this book teaches you. The basic free time for disability is easy for beginners to understand and to be a renewal for the Senate. This book explains how the horse's unique characteristics, such as health, habits and abilities, are implemented when deciding whether to bet on the horse or not. Horseplayer who learns how to know and use the horse's characteristics can then assume that winners will be in the future. This foundation provides a practical way to choose a winner and avoid losing.
2. Horseback Riding, Richard Eng (2005)
Want to join the circuit with a group of friends and feel like you know what you do? Want to be able to put better games that increase your chance to go home with a dollar in your pocket? Reading this book answers those questions for you. With more than 20 years & # 39; Experience in horse riding, Eng directed this book to learn how to bet and how to increase the odds of winning. He does not go into the depths of talent skills. This book teaches you how to read the contests, which serious bettors use to increase the chances of winning. It's an excellent glossary at the end where the author explains all the concepts in the industry so that you can understand every word he uses to describe the horse presentation.
3. The Complete Handicapper, James Quinn (2013)
This book can help the beginning of horseplayer as well as an experienced handicapper. It has been said that it is necessary to read for those who are seriously putting more attractive than losing bets. James Quinn has over 40 years of horse riding experience and has presented his most important basic skills that he learned in these years and new ideas he learned in this 21st century adult racing, all in this single book.
4. Greg Boomer Wry (2005)
How to turn some driving into your own money machine (and just be one of the 2% who do it) It's up to you. It's designed to teach you anything about horseback riding disabilities, from learning bad bet, to managing your money so you have better prospects for success. With that you will learn the skills to last a lifetime. This included book uses highly understandable terms that are defined and explained, sometimes by giving an example. You must learn how to analyze race by reading and understanding the daily racing form and evaluating each horse to determine whether to bet on the race.
5. Best Betting: DFR Press (2001)
Experts from the United States at the time when it was released was the most comprehensive book on adult disability that appeared for more than a decade. With nine different sections written by nine different authors on nine different issues in the raceway, this book will appeal to beginners and specialist skills. Examples section include Beyer on Simulcasting, Quinn on the bench and Brohamar in tact. If you do not want to buy 9 separate books on these 9 separate topics, this book will be a good place to start learning about each of them.
6. Betting Thoroughbreds for the 21st Century: A Professional Guide for Horseplayers, Steven Davidowitz (2009)
This book is revised and updated third edition to the author's classic "Betting Thoroughbreds", first published three decades ago. The book is so popular and has such dedicated followers including new racing fans and veteran players, that there has been a racing industry standard for disability for decades. This recently revised version explains recent industrial changes, such as ready-made, & # 39; great coaches & # 39; rumors, computer programs and more. Have you ever looked at the horse's past and wondered what was going on in the race today? This book will answer that question as well as countless others. A wide variety of subjects, such as the bias of training, are among those that are covered. This industry standard manual book will be a favorite read for the start of horseplayers as well as a welcome renewal for horseplayers experience.
7.The best of thoroughbred handicapping: Counseling on Disability, James Quinn (1987).
The Quinn book contains 48 essays of some of the most knowledgeable scholars, including Tom Ainslie, Andrew Beyer, William Quirin and himself. Individual essays explain the authoring system and give examples of how each one works. Some of the systems are too complex to fit into one section and the dissertations are difficult to follow. But in general, the essays stimulate the honeymoon of appetite to read the original books that are listed in an annotated bibliography. Themes ranging from betting strategies to speed up the visual analysis of horses in the capsule make this extensive collection of writings useful for all types of hands. If you are looking for a well-chosen book on disability methods, this may be the one that is.
8. Outstanding bet: How to make multi-disciplinary, multi-storey bet and win more competition in the race, Steve Crist (2006)
"Athlete is only half the battle, bet is the other." Crist is aiming for a horse player to make the most money by betting on numerous alien bets, including daily double, exactly, trimecta, quinella, superfecta, choose 3, 4 and 6. Crist says this book is not about picking winners on trackbut theory that how to bet is as important as anyone you want – especially in the 21st century in horse games where new ways to bet such as superfecta and pick four have been done at the usual work, venue and exhibition of days & # 39; before. Both serious and casual horseplayers will benefit from the understanding of the methods and tactics of making these alien bets.
9. Modern Pace Handicapping, Tom Brohamer (2000).
"Pace makes the race" is one of the oldest words you will hear on a raceway, and this book is going to book in line with disability. For beginners will read about running styles give an insight into how the race will be executed and what horses will benefit from the likely pace of scenarios. For experts, the Sartin Methodologychapter releases a new method for detecting the speed of the race. The author used Sartin Methodology to develop his own technique for handicap on horse games. He looked at running style, turning times, tracking variations, energy distribution, and twice predicting the strategy and revenue in the race. Daily Racing Form Tables are posted through the book.
10. Ainslie's Complete Guide to Thoroughbred Racing, Tom Ainslie (1988)
This third edition is referred to as "the most complete, comprehensive and reliable guide for handling and understanding of adult racing." While some of her ideas may be outdated to today's racing standards, countless generations of teeth are cutting their teeth on basic skills. Ainslie teachers – the skills needed to help you become a specialist holder & # 39; and to be able to continually choose the winner on the track. Some of the author's basics include category, distance, shape, speed, tracing conditions, jockeys and mentors and cultivation.
After taking the time to read this article about these incredible books about learning to betting and building your disability, remember to subscribe to free hiring tips as http://bettingforwinners.com ] with our free horse games.

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Looks Like D&D Online will be returning to my weekly gaming habits tomorrow with the start of weekly DDO gaming sessions.
Then we get the very irregular C&C game returning to the occasional saturday nite in October. We will see how many of the old group return to the game that's been on hiatus since the end of May.
I also announced to my "crew" of mmorpg'ers / old face to face rpg group my intention to run a game using the yet to be released iTabletop 2 software in November.
#Dungeon23 Tomb of the Vampire Queen, Level 3, Room 28 - This room is really a wide hallway with many smaller cells on each wall to the left and right. There are four on each lower row on both sides and four ab...
3 hours ago
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Get more out of your beach getaway at the Beach House Dewey hotel. Take advantage of our exclusive hotel deals, vacation packages and seasonal specials offers to save big on stays at our seaside hotel in Dewey Beach, Delaware. Beach House Dewey preferred pricing discounts and hotel offers are available exclusively for stays booked directly on our website or by calling the hotel direct. Find a vacation package that fits your calendar and budget, and start packing for a relaxing beach escape to Dewey Beach.
Come Play Hooky!
Playing Hooky just got better, book 4 nights and get the 5th night free! Book by Clicking Here. Use promo code "HOOKY" or call us today 302-227-4000!

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Andrea was born and raised in Connecticut. She has been with Farmington Village Dental since 2002 when she started out as Dr. Nadeau’s only employee. When Andrea joined Farmington Village Dental she was both the dental assistant and the receptionist. These days she spends the majority of her time on the business side. She schedules appointments, processes dental insurance, and makes financial arrangements. Meanwhile, she still occasionally assists Drs. Nadeau and Krause during dental procedures. Andrea does a lot to help our office run smoothly, and we are so thankful for her many talents! In her personal life Andrea is married to her high school sweetheart, Phil, and has two sons. In her free time, Andrea loves running, playing soccer, and doing art projects.
Stephanie was born and raised in New Hampshire. She is a dental assistant and has been with Farmington Village Dental since 2008. Stephanie has two daughters and enjoys country music and spending time with family and friends. When she gets the chance, she also enjoys snowboarding. An interesting fact about Stephanie is that she used to work on a cruise ship!
Ashley was born and raised in Connecticut, and currently resides in Burlington with her husband and her fur baby named Saber. She received her dental hygiene degree from Tunxis Community College and has been a part of the Farmington Village Dental team since 2013. In her free time Ashley loves to travel and do any and all outdoor activities.
Sue was born and raised in CT and has been with Farmington Village Dental since 2015. She is a Dental Assistant who assists our doctors with procedures. Sue says the best thing about being a dental assistant is the connections she gets to make with our patients, helping them feel more comfortable and confident during their dental treatment. Sue has two grown daughters and lives in Berlin with her husband, Bill. In her free time you can find Sue in her garden, doing DIY projects, or spending time at the beach. In a previous life Sue worked with a florist and she is the talent behind many floral arrangements and decorations you see in our office. Another fun fact about Sue is that she used to own a costumed balloon delivery service.
We look forward to treating you!Schedule an Appointment
A Little More About Our Practice…
Continuing Education & Training
Rest assured that we are fully trained and certified to provide you with the most up to date dentistry you are looking for. Several times a year the entire staff attends dental conferences and seminars to keep informed about new developments in patient care, new products, equipment, and advancements in dental treatment techniques.
Patient Consultation & Information
Knowledge is power. We want to empower you to make informed decisions about your oral health. The first step to evaluating dental health is to actually look at overall health by reviewing your medical history as well as reviewing your current medications. Next, we will examine all of your teeth visually. To aid us in this process, we may use an intraoral dental camera that enables us to take pictures so you get to see what we see in your mouth. If we decide they are necessary we will also take x-rays. Finally, we will discuss with you what we see, and we will discuss what your treatment options are. It will be up to you to do as much or as little as you want, in a time frame that is comfortable for you. We help you make healthy choices!
Positive Childhood Dental Visits
Early dental care ensures healthier teeth and better facial growth for your child, and it can also lower the cost of dental treatment needed in later years. More than 1 in 4 children in the U.S. have cavities by age 4, and some as early as age 2. We want to reduce your child’s risk of developing cavities so we often have conversations with parents about food choices and dietary habits that affect oral health. We believe that a very important part of childhood dental visits is learning how cavities happen. We do our best to make it easy and fun for both parents and children to learn about good oral health habits. We are here to provide positive dental experiences for your child (and you) right from the first visit!
What Patients Say about Us:
“The hygienists are among the nicest, most helpful people I have ever met. They really explained everything and that helped me understand why I need what I need.” — Marie V.
“I love Dr. Nadeau and her team. My husband and son are also patients, and we all love the personal treatment we receive at Farmington Village Dental and the cleanliness of the office.” — Laurel Y.
“Always a good experience. Staff is friendly, efficient & helpful.” — Sheila G.
“I can’t say enough about the professional care given to me at all times at Farmington Village Dental. The entire staff is just great! They are courteous, friendly, and always smiling.” — Jeanne B.
“I have always been dentist phobic, but this place has cured me of that! They treat you like a person and not just another job to complete. Highly recommend this practice!” — John F.
“Happy happy happy! I am so happy I found a place that is good for both me and my kids. Nothing ever hurts, they run reasonably on time and everyone is friendly.” — C. Anukin
“I’ve been a patient for over 8 years at Farmington Village Dental and have always had a very positive experience! A great team that is up-to-date on the latest techniques.” — Ed P.

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AVLYST! David Sweeney: Life in the Multiverse, Fictional Worlds, Territorialisation and the Reality of Fiction
Open lecture with Dr. David Sweeney, Glasgow School of Art, Lecturer, Forum for Critical Inquiry.
His work has focused on:
1) The narrative strategies involved in the production of comic books and their relationship to the technology used in this production, with particular emphasis on digital comics
2) Practices of reading involved in the consumption of comic books, in both print and digital form, and their relationship to existing and emerging publication technology.
The lecture will be held in English.


TEACHERS OWED R200M
The Limpopo department of education has been using thousands of temporary teachers without paying them for three years.
The department is now struggling to pay the nearly 3000 teachers and claims it does not have the R200million required to pay them.
The teachers have not been paid since 2007.
The teachers were not paid because the department had delayed to implement a collective agreement resolution.
An agreement between the department and the unions in 2008 stipulates that the department will pay the temporary teachers 37percent of the benefits due to them.
Most of the affected teachers said they were forced to work for incomplete salaries because they were desperate for jobs and willing to help pupils, though they were rewarded with mistreatment.
One of the teachers told Sowetan that the situation was so demoralising that standing in front of pupils was a hard task.
"We are dealing with a department that is not helpful. How does it fail to stick to an agreement taken three years ago?" asked the angry teacher.
But education authorities said yesterday they were addressing the problem and that they had already made payments to teachers in the Waterberg district.
Departmental spokesperson Pat Kgomo said the problem was caused by budget constraints.
He confirmed that they had stopped paying the teachers because the department wanted to conclude the occupation specific dispensation agreement, but that lack of funds had precluded them from implementing the resolution.
Kgomo said the department had failed to pay the teachers because "it required more money that was not budgeted for".
"We had to suspend the process, but the situation will be resolved soon," he said.
The department also faces criticism for failing to appoint temporary teachers into permanent positions by terminating their contracts.


Nestle plans to spend as much as 2 billion Swiss francs ($2.1 billion) in a plan to push the plastics industry to address the dearth of recycled packaging that’s safe to use for food.
The KitKat maker will earmark more than 1.5 billion francs to pay a premium for such plastic to encourage production, the company said. Recyclers have tended to neglect that market because of the difficulties in making non-toxic food-grade packaging.
National Highways Authority of India (NHAI) has charted a Rs 3.10-lakh crore plan to build 22 greenfield expressways as part of a plan to decongest major cities, Union minister Nitin Gadkari said.
Of the 7,500 km new roads, NHAI plans to build six expressways of 2,250 km, entailing an investment of Rs 1.45 lakh crore, while another 16 greenfield corridors with aggregate length of 5,250 km will require an investment of Rs 1.65 lakh crore.
The asset manager BlackRock’s announcement that it will pull out its investments in companies that get 25% their revenues from thermal coal production, besides making no future direct investment in such firms, could shrink the bouquet of investors for players like NTPC, the Adani group and Coal India (CIL).
Concerned over rise in imports in the ‘others’ category, Commerce and Industry Minister Piyush Goyal asked those importers to seek HSN or tariff code within 30 days from the foreign trade office, failing which the government would impose strong restrictions on their inbound shipments.


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Rio Grande Red Cabbage is a hybrid red cabbage variety known for the large heads it produces. In a university study at LSU, Rio Grande outperformed 8 other red cabbage varieties and was consistently the largest. Heads average 4-5 lbs and have a red exterior and interior. Rio Grande Red Cabbage heads have large wrapper leaves to protect the harvestable portion of the heads, which have a superb, crisp texture that’s great raw or cooked. Rio Grande is considered an all-season variety as it can be grown year-round in many climates.
Cabbage will grow best in areas where weeds are kept to a minimum. Cabbage is moderately frost-tolerant and performs better when planted in cooler weather. Cabbage will tend to bolt in warmer temperatures. Plant cabbage early in spring for a late spring/early summer harvest, or plant in late summer/early fall for a fall harvest. Cabbage are heavy feeders and require a considerable amount of nitrogen for larger heads. For best results, inject or soil drench with a balanced fertilizer at least once every two weeks. If smaller heads are desired, less fertilizer will be adequate.
Rio Grande may be direct-seeded or transplanted, although we suggest transplanting. Transplanting allows for more consistent plant spacing and prevents seedlings from competing with weeds in the early stages of the plant. We recommend starting transplants 3-4 weeks before the desired outdoor planting date. Rio Grande Red Cabbage transplants grow great in our heavy-duty seed starting trays, where they develop a solid root ball with roots that are trained to grow downward. Plants are ready to go in the ground when they can be easily pulled from the cells in the seed starting tray.
Rio Grande Red Cabbage Planting Information
Planting Method: direct seed or transplant
When to Plant: early spring and fall
Planting Depth: 1/4″
Seed Spacing: 12″
Row Spacing: 2-3′
Days to Maturity: 75
Disease Resistance: None


ERGO is a decentralized and open-source cryptocurrency that introduces multiple improvements to different layers of the blockchain. ERGO intends to create a truly decentralized platform and provide accessible tools for trustless blockchain exploration and verification. ERGO is designed for mass adoption. Its efficient blockchain protocol will allow it to be widely used while still remaining friendly to application protocols thanks to its unique transaction language. ERGO implements numerous scalability enhancements resulting in the ability to process thousands of transactions per second without mining centralization or an decreasing number of full nodes.
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The first game that was played in the premier league competition yesterday was between Everton and West Ham United. Everton who has been without their key players in recent week due to Injuries, suffered their second premier league defeats of the season yesterday, as West Ham narrowly defeated them 1-0.
Moments after West Ham won Everton 2-0, Newcastle then hosted Tottenham hotspur in the last fixture of the premier league competition yesterday. Tottenham who are looking forward to finishing in the top four position this season after missing out last season, narrowly defeated 10 man Newcastle United by 3 goals to 2, with Harry Kanescoring his first premier league goal of the season.
Goal Scorers Table:
1. Mohammed Salah – 7 goals
2. Jamie Vardy – 7 goals
3. Antonio – 5 goals
4. Sadio Mane – 5 goals
5. Bruno Fernandes – 4 goals
6. Roberto Firmino – 4 goals.
7. Son – 4 goals
8. Mason Greenwood – 4 goals
9. Maupay – 4 goals
10. Sarr – 4 goals.
Below is how the premier league table currently looks like after yesterday’s fixtures.
Verdicts: Norwich are the first favourite team to be relegated from the EPL tournament this season, as they are yet to record a victory since their promotion into the competition. Newcastle United on the other hand, may also get relegated if they fail to strengthen their squad in January.
What are your thoughts about this? Kindly leave a message in the comments section below.
- Observations Made After Graham Potter’s Chelsea Defeated Crystal Palace 2-1 Away
- Things Graham Potter did that helped Chelsea defeat Crystal Palace 2-1 today at Selhurst Park
- Connor Gallagher’s Message To Chelsea Fans After Scoring His First Chelsea Goal.
- Watch Inter Milan vs Roma Live Streaming Match #RomaInter #InterRoma #INTROM
- Why Graham Potter’s 3-5-2 Formation Against Crystal Palace Is A Dynamic Set-up


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We studied the role of the NC_000017.10:g.38051348A>G (rs8067378) single nucleotide polymorphism (SNP) located 9.5 kb downstream of gasdermin B (GSDMB), in the development and progression of cervical squamous cell carcinomas (SCC).
Using high-resolution melting curve analysis, we genotyped this SNP in patients with cervical SCC (n = 486) and controls (n = 511) from the Polish Caucasian population. Logistic regression analysis was used to adjust for the effect of confounders such as age, parity, oral contraceptive use, tobacco smoking, and menopausal status. The effect of this SNP on the expression of GSDMB was studied by reverse transcription and quantitative real-time polymerase chain reaction analysis of GSDMB transcript levels in SCC tissues.
For all patients with SCC, the p trend value calculated for rs8067378 was statistically significant (p trend = 0.0019). The adjusted odds ratio for the G/G vs. A/A genotype was 1.304 (95% confidence interval 1.080–1.574, p = 0.0057) and the adjusted odds ratio for the G/A + G/G vs. A/A genotype was 1.444 (95% confidence interval 1.064–1.959, p = 0.0181). We also found a significant association of the rs8067378 SNP with tumor stages III, IV, and grade of differentiation G3, and with parity, oral contraceptive use, smoking, and women of postmenopausal age. We found increased GSDMB1 isoform transcripts in the cancerous and non-cancerous tissues from carriers of the G allele vs. carriers of the A/A genotype.
The rs8067378 SNP variants may increase the expression of GSDMB and the risk of the development and progression of cervical SCC.
The online version of this article (doi:10.1007/s40291-017-0256-1) contains supplementary material, which is available to authorized users.
Cervical cancer (CC) is one of the most common tumors in women and remains one of the main causes of death among women worldwide . The precancerous state of cervical intraepithelial neoplasia, which may progress to CC, is usually the result of persistent infection with one of the oncogenic high-risk human papillomavirus (HPV) strains . HPV E6 and E7 oncoproteins impair the function of p53 and pRb proteins and drive the cells to uncontrolled proliferation . Additionally, E6 and E7 oncoproteins lead to chromosomal aberration . It has been observed that the most high-risk HPV virions are eliminated by the hosts’ immune system and only a minority of infections lead to a cervical lesion [5, 6]. These studies indicate that long-term infection with high-risk HPV contributes to cervical carcinogenesis; however, this further depends on an individual’s genetic background [5, 6]. The risk factors for CC also include multiparity, cigarette use, sexual history, abnormalities in the immune system, and environmental pollutants [7–10]. Important risk factors for CC are heritable genetic components, including a family history of cancer, especially in first-degree relatives . The recently carried out genome-wide association studies highlight the major histocompatibility complex region in particular as being associated with cervical carcinogenesis [12–14].
Additionally, genome-wide association studies in the Chinese population have demonstrated invasive CC to be associated with polymorphisms within two non-major histocompatibility complex loci: among them was the NC_000017.10:g.38051348A>G (rs8067378) single nucleotide polymorphism (SNP) . The products of gasdermin B [GSDMB (OMIM *611221)] are the four protein isoforms GSDMB1–4 . It has been demonstrated that the GSDMB protein may be linked with CC development and progression . We replicated the prevalence of the rs8067378 SNP in patients with cervical squamous cell carcinomas (SCCs) in the Polish Caucasian population and we assessed the association of this SNP to different stages and grades of differentiation. We also evaluated the effect of rs8067378 genotypes on this gene’s transcript isoform GSDMB1–4 levels in primary SCC and non-cancerous tissues.
The study population consisted of 486 patients with cervical SCC, with stage and grade of differentiation assessed by an experienced histopathologist based on the International Federation of Gynecology and Obstetrics classification system and the World Health Organization (Table 1). Patient data and primary cervical SCC tissue samples were obtained from patients enrolled between October 2007 and August 2015 at the Department of Radiotherapy of the Greater Poland Cancer Center in Poznań, Poland. The control group consisted of 511 unrelated healthy female volunteers selected during a medical examination at the University Hospital, Clinic of Gynecological Surgery at Poznań University of Medical Sciences (Table 1). Information regarding a parity of at least one, oral contraceptive use, active tobacco smoking at minimum within the last 12 months, and menopausal status was obtained as part of the control and patient history.
The primary SCC tissue samples were obtained from 47 patients with a mean age of 51.6 ± 10.2 years and classified as stage III at the time of surgery. The non-cancerous cervical tissue samples were obtained from 47 women with a mean age of 51.4 ± 9.8 years and with uterine fibroids undergoing uterine surgical resection in the Division of Gynecological Surgery, Poznań University of Medical Sciences, Poznań, Poland. A portion of the tissue sample was immediately snap frozen in liquid nitrogen and stored at −80 °C until RNA isolation. All the patients and controls participating in the study were Caucasians from the Wielkopolska area of Poland. Written consent was obtained from all participating individuals. The study procedures were approved by the Local Ethics Committee of the Poznań University of Medical Sciences (Reference no. of ethical approval: 1010/07).
DNA was isolated from peripheral blood cells via a salting-out procedure. The primers were designated employing Oligo 7.6 software (DBA Oligo, Inc., Colorado Springs, CO, USA). The rs8067378 polymorphism DNA fragment (225 bp) was amplified using the primers forward 5′ GAAAGAAGAGCACAGATAAAC 3′ and reverse 5′ CGGATGACTGGTGAAATAAGC 3′. The rs8067378 SNP was then genotyped via high-resolution melting curve analysis using HOT FIREPol EvaGreen (Solis BioDyne, Tartu, Estonia) with a LightCycler 480 system (Roche Diagnostics, Mannheim, Germany). The presence of this SNP was reanalyzed by Sanger sequencing analyses of randomly selected samples comprising 10% of the samples from all of the participants. The concordance rate between high-resolution melting and sequencing was equal to 100%.
Frozen SCC and non-cancerous tissues were homogenized and total RNA was isolated according to the method of Chomczyński and Sacchi . RNA quality was determined spectrophotometrically using a BioPhotometer® from Eppendorf AG (Hamburg, Germany) and agarose gel electrophoresis. RNA samples were treated with DNase I, quantified, and reverse transcribed into complementary DNA (cDNA) with the Moloney Murine Leukemia Virus from Invitrogen (Life Technologies, Carlsbad, CA, USA) [Online Resource 1].
Quantitative analysis of GSDMB1–4 cDNA isoforms (Online Resource 1) was performed by Light Cycler®480 II Real-Time PCR System (Roche Diagnostics GmbH, Mannheim, Germany), using SYBR Green I as the detection dye. GSDMB1–4 cDNA was quantified using the relative quantification method with a calibrator. The calibrator was prepared with a cDNA mix from all cDNA samples and consecutive dilutions were used to create a standard curve. For amplification, 1 µL of cDNA solution was added to 9 µL of LightCycler 480 SYBR Green I Master Mix (Roche Diagnostics GmbH, Mannheim, Germany) and primers (Online Resource 1).
The quantity of the GSDMB1–4 transcript in each sample was standardized by the geometric mean of reference transcript levels: hydroxymethylbilane synthase and β-2-microglobulin. The polymerase chain reaction amplification efficiency for target and reference cDNA was determined by different standard curves created by consecutive dilutions of the cDNA template mixture. The GSDMB1–4 cDNA, hydroxymethylbilane synthase, and β-2-microglobulin cDNA were amplified using the primer pairs presented in Online Resource 1. The GSDMB mRNA levels were expressed as multiples of these cDNA concentrations in the calibrator.
The distinction in genotypic prevalence between the patients and controls and their genotype deviation from the Hardy–Weinberg equilibrium were evaluated using a χ 2 test. The polymorphism was tested for association with CC incidence using the Cochran–Armitage p trend test (p trend). The χ 2 and Fisher exact tests were used to determine the differences in genotypic distributions between the patients and controls. The odds ratio (OR) and 95% confidence intervals (CIs) were also calculated. A logistic regression analysis was used to adjust for the effect of confounders such as age, parity, oral contraceptive use, tobacco smoking, and menopausal status. A p value of <0.05 was considered statistically significant. Statistical analysis of comparing GSDMB1–4 isoform transcript levels between the G/G vs. A/A and A/G vs. A/A genotype carriers was evaluated by the Kruskal–Wallis test with either Dunn’s post-hoc test or Tukey’s post-hoc test. Statistical analyses were conducted using Statistica version 10, 2011 (Stat Soft, Inc., Tulsa, OK, USA).
The values for the χ 2 test of the Hardy–Weinberg equilibrium were 0.329 and 0.181 for the patients and controls, respectively. The statistical evaluation of the rs8067378 genotype prevalence in cases and controls are shown in Table 2. For all patients with SCC, the p trend value calculated for the rs8067378 transition was statistically significant (p trend = 0.0019). The logistic regression analysis, which adjusted for the effects of age, parity, oral contraceptive use, tobacco smoking, and menopausal status, also demonstrated a contribution of the rs8067378 SNP to cervical SCC development (Table 2). We observed that the G/G vs. A/A genotype is a risk factor of cervical SCC with an adjusted OR of 1.304 (95% CI 1.080–1.574, p = 0.0057). We observed the same risk effect of the G/A + G/G vs. A/A genotype, with an adjusted OR of 1.444 (95% CI 1.064–1.959, p = 0.0181). However, we did not find an association with cervical carcinogenesis for the G/A vs. A/A genotype, adjusted OR of 1.302 (95% CI 0.944–1.794, p = 0.1069).
Stratified analyses revealed an association of the rs8067378 genotypes with tumor stages III, IV, and grade of differentiation G3 (Table 2). The p trend value calculated for the rs8067378 SNP in cervical SCC patients with stages III and IV was statistically significant (p trend < 0.0001 and p trend = 0.0452, respectively). Adjusting for the effect of age, parity, oral contraceptive use, tobacco smoking, and menopausal status in patients with stages III, the logistic regression analysis demonstrated that the G/G vs. A/A genotype is a risk factor of cervical carcinogenesis with an adjusted OR of 1.674 (95% CI 1.260–2.225, p = 0.0004). There was also a risk effect of SCC for the G/A vs. A/A genotype, with an adjusted OR of 2.180 (95% CI 1.316–3.61, p = 0.0024) and for the G/G + G/A vs. A/A genotype, with an adjusted OR of 2.696 (95% CI 1.668–4.367, p = 0.0001) in stage III patients.
In patients with grade of differentiation G3, the p trend value calculated for the rs8067378 SNP was statistically significant (p trend = 0.0004). We found a risk effect of the G/G vs. A/A genotype, with an adjusted OR of 2.004 (95% CI 1.305–3.078, p = 0.0014) for the G/A vs. A/A genotype, with an adjusted OR of 2.346 (95% CI 1.180–4.666, p = 0.0148), and for the G/G + G/A vs. A/A genotype, with an adjusted OR of 2.782 (95% CI 1.437–5.389, p = 0.0024). However, the logistic regression analysis did not show any association of the rs8067378 SNP with tumor stage I, II, and IV and grade of differentiation G1, G2, and GX. Moreover, there was no contribution of the rs8067378 SNP with HPV strains to either SCC or tumor stage I, II, and IV and grade of differentiation G1, G2, and GX (data not shown).
The stratified analysis for the rs8067378 polymorphism revealed a risk role of this SNP among patients with a positive history of parity, oral contraceptive use, smoking, and among women of postmenopausal age (Table 3). The age-adjusted OR for women with a history of parity for G/G vs. A/A was 1.323 (95% CI 1.083–1.615, p = 0.0059) and for G/G + G/A vs. A/A was 1.484 (95% CI 1.071–2.055, p = 0.0174). The age-adjusted OR for women with a history of oral contraceptive use for G/G vs. AA was 1.376 (95% CI 1.043–1.816, p = 0.0232). The age-adjusted OR for women with a history of tobacco smoking for G/G vs. AA was 1.666 (95% CI 1.195–2.322, p = 0.0024) and for G/G + G/A vs. A/A was 1.958 (95% CI 1.133–3.384, p = 0.0157). The age-adjusted OR among women of postmenopausal age for G/G vs. A/A was 1.334 (95% CI 1.059–1.679, p = 0.0138).
We observed statistically significant increased GSDMB1 isoform transcript levels in the SCC cervical tissues from carriers of the GG vs. A/A (p = 0.00001) and G/A vs. A/A (p = 0.017) (Fig. 1a). We also found a statistically significant increase in the GSDMB1 transcript levels in the non-cancerous cervical tissues from carriers of the GG vs. AA (p = 0.000001) and G/A vs. A/A (p = 0.033) (Fig. 1b). There were also statistically significant increased GSDMB2 and 3 isoform transcripts in the SCC cervical tissues from carriers of the G/G vs A/A genotype (p = 0.010, p = 0.035, respectively) (Fig. 1a).
However, we did not find significant differences in GSDMB2 and 3 isoform transcript levels in the SCC cervical tissues for the GA vs. AA genotype (Fig. 1a). There were also no significant differences in GSDMB2 and 3 isoform transcript levels in non-cancerous cervical tissues from carriers of the G allele as compared with carriers of the A/A genotype (Fig. 1b). We also did not find significant differences in GSDMB4 isoform transcript levels in SCC cervical tissues and non-cancerous cervical tissues from carriers of the G allele as compared with carriers of the A/A genotype (Fig. 1b).
The GSDMB gene is located at 17q21.2, a region that contains the ERBB2 gene, and is frequently amplified in cancers [17–19]. GSDMB expression is driven by two promoters: the cellular promoter and the Long Terminal Repeats-derived promoter [20–22]. The studied NC_000017.10:g.38051348A>G (rs8067378) SNP is situated 9.5 kb downstream of the GSDMB, in a region suggested to be a functional polymorphism as part of the transcriptional regulatory element and/or modulator of chromatin structure in this domain [23, 24].
Human GSDMB is transcribed in proliferating normal epithelial cells and is overexpressed in various carcinomas, including those of the esophagus, breast, liver, stomach, colon, and uterine cervix [15, 25–29]. Sun et al. reported that GSDMB may also contribute to the development and progression of uterine CC . They demonstrated that the GSDMB protein was present at increased levels in CC tissues as compared with the adjacent cancerous tissues and corresponding normal tissues .
We found the rs8067378 SNP to be a risk factor of cervical SCC among all patients from the studied Polish Caucasian population. To date, the minor allele G of rs8067378 has been found to be a significant risk factor for cervical carcinogenesis in Han Chinese and Japanese populations [13, 29].
We also observed that the rs8067378 polymorphism was associated with stages III and IV of cervical SCC. This suggests that there is a role of the G variant of rs8067378 in the increased extension and spread of malignant cells to neighboring tissues. In our studies, the rs8067378 variant was also observed to be associated with differentiation grade G3, which is prone to grow rapidly and spread faster than lower-grade cancerous cells. Our findings are similar to the recent replication study in a Japanese population, in which the authors demonstrated that Japanese women with the rs8067378 GG genotype belong to a high-risk group for invasive CC .
Moreover, there was an increased risk of cervical carcinogenesis for the rs8067378 SNP in patients with a positive history of parity, oral contraceptive use, smoking, and women of postmenopausal age. This is consistent with literature data indicating the causative influence of pregnancy, oral contraceptive use, tobacco smoking, and postmenopausal age in cervical carcinogenesis [7–10].
The rs8067378 SNP has also been associated with the development of asthma [24, 31, 32]. Functional studies conducted for the rs8067378 SNP demonstrated reduced expression of GSDMB for the G gene variant of rs8067378 in human bronchial epithelial and bronchial alveolar lavage cells from patients with asthma . In contrast, we found significantly upregulated GSDMB1 isoform transcript levels in both the cervical SCC and non-cancerous tissues from carriers of the G allele as compared with carriers of the A/A genotype. Additionally, we observed significantly increased GSDMB2–3 isoform transcript levels in the cervical SCC tissue for carriers of the G/G vs. A/A genotype. These discrepancies may be owing to the use of different quantitate assays and analyses of different GSDMB isoform transcripts between the asthma study  and ours. These may also have resulted from distinct transcription and epigenetic factors regulating the expression of GSDMB in lung tissues and cancerous and non-cancerous cervical tissues.
The increased expression of GSDMB for carriers of the rs8067378 G gene variant confirm the observation of Sun et al. They demonstrated that ectopic GSDMB expression augmented the growth of CC cells in vitro, whereas silencing the endogenous expression of GSDMB reduced cancer cell proliferation .
Our genetic study is the first to report that the rs8067378 polymorphism can be a risk factor for cervical carcinogenesis in a Caucasian cohort. Moreover, we observed that the rs8067378 G variant upregulated the expression of GSDMB, which was associated with increased growth and spread of cancer cells to the surrounding tissues. However, our study contains some limitation, for instance, one Caucasian cohort with a relatively small sample size. This study is also limited to one tested SNP. To achieve full gene coverage, a number of other tag SNP needed to be covered in this study. Other SNPs not included in this study could account for alternation of GSDMB expression. Therefore, our genetic study should be replicated for rs8067378 and a number of other tag SNPs covering GSDMB in other independent ethnicities.
Below is the link to the electronic supplementary material.
We gratefully acknowledge the technical assistance of Ms. Agnieszka Mikuczewska.
LA, RA, LM, SA, SE, and JPP have no conflicts of interest to report.
This study, presented by LA, RA, LM, SA, SE, and JPP, was funded by Grant No. 502-01-01124182-07474 from Poznań University of Medical Sciences. Open access was funded as part of the Open Access agreement between Springer and the ICM University of Warsaw, acting on behalf of the Polish Ministry of Science and Higher Education.
The study procedures were approved by the local Ethics Committee of the Poznań University of Medical Sciences. Informed consent was obtained from all participating individuals.


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Over at Hechinger Report, Brandon Cardet-Hernandez has an idea about how to "solve the education crisis"-- pay students to go to school. Well, specifically, pay 16-and-older students to attend after-school enrichment programs, extended "summer learning" and work study programs.
Cardet-Hernandez has knocked around education for a couple of decades. Currently he's the executive director of the Ivy Street School (a "therapeutic approach" school) and an appointed member of the Boston School Committee. He was the turnaround guy for a school in New York City as well as senior education advisor to Mayor Bill DeBlasio. During his four years as a special ed classroom teacher, he "developed a comprehensive, Common Core-aligned curriculum focused on History through an anti-oppression framework."
Despite all that, he loses me in his second paragraph when he cites Thomas Kane's notion that, "recent NAEP scores showed startling declines that could amount to as many as 22 weeks of learning loss." Anyone who claims they can measure learning in weeks or months or years or hectares or liters is just shoveling baloney. What they actually mean is "test scores are down," but you can't get people worked up about that.
But Cardet-Hernandez wants us to know that "we are not approaching a crisis, we are already in one." Spoiler alert: he's not going to actually define the crisis beyond "test scores are down." Also, "chronic absenteeism is on the rise" he notes, linking to an article whose actual headline is "Pandemic Causes Alarming Increase in Chronic Absence and Reveals Need for Better Data" on a website for a group created in 2016 to sound an alarm about school attendance.
Students' lives are different now, he notes, and so schools will have to do different things.We often talk about simply making up lost learning time, but it’s not that simple. Like lost sleep, lost learning time cannot be reclaimed — but we can chart a new course that will set students up for success.
If we want to tackle learning loss and absenteeism with the necessary level of response, we could also use ESSER funds to employ students in age-appropriate job positions at their schools and in their cities. Think lunch prep in a cafeteria or clerical work in an administrative office, for example.


Tuesday, October 29, 2013
Authoritarian Government Control Is Real! RWNJ's Yawn.
Katie bar the door - the government IS coming for you and they will hold you without due process for as long as they want - and there's not a thing you can do about it.
We're not talking about Guantanamo or undocumented detention centers. F' them. We're talking about white, pregnant ladies from West Bend, Wisconsin.
It's true! But how could this happen in a state like Wisconsin, protected by our patron saint of personal freedom, Scott Walker?
Why haven't our well-armed militias taken to the streets? Who better to protect from statist, crypo-facist, government jack-booted thugs than pregnant ladies from the suburbs?
Where the fuck are the Oathkeepers?!
(For the record, they are glued to Fox and the Blaze, wringing their hands over unanswered questions about Benghazi - with no time to worry about some unmarried pregnant woman in Wisconsin who probably voted for Barack Obama and practices witchcraft - or worse - secular humanism.)
Alicia Beltran of Jackson, Wisconsin was 14 weeks pregnant when she went for a prenatal check-up. Alicia gave a full medical background history that included a previous addiction to pain killers. Alicia also told the medical professionals that she had beaten the addiction - which urine tests confirmed.
Alicia was told to take an anti-addiction drug, which she did not want or need. A few days later Alicia was arrested and taken into custody at her home and held in a treatment center against her will for 3 months. Alicia lost her job and is now suing the state.
You really must watch the whole story here:
So this law has been on the books for well over a decade - it's a fluke you might say - surely designed to prevent harm in the worst cases. You'd be half right. It was even called the "Cocaine Mom" law at the time.
Assembly Bill 463 was introduced by none other than Bonnie Ladwig who represented the 63rd district - the one Robin Vos now represents (and should be renamed assembly district "666.") Ladwig was charged and pleaded guilty in the infamous caucus scandal in 2002. After her fall from disgrace, she served as Vos' treasurer until people noticed and Vos replaced her with his future ex-wife - he just has a miserable record with women, doesn't he?
At the time of it's introduction, critics of the bill said it was poorly written, was most assuredly unconstitutional because of it's failings in both due process and medical confidentiality and would probably result in more women avoiding prenatal treatment instead. Ya think?
The bill was hailed by Wisconsin pro-life groups like the infamous Wisconsin Right to Life organization.
So what's one poorly written law compared to the freedom of the unborn?
Well, the National Advocates for Pregnant Women have noticed an interesting by-product in states that enacted fetal child abuse laws - the cases of pregnant mothers charged have been rising in relation to or at the effect of "personhood" type sentiments in those states.
Beltran's unborn child received a lawyer, but she was told by the judge she was not entitled to one.
Just this summer a pregnant Mississippi woman was charged with manslaughter for the still-birth death of her child at 33 weeks which allows prosecution against women who engage in "risky" behavior. That's what is says - risky. That essentially could mean freebasing cocaine or wearing shoes lighter than your hemline - depending on a prosecutors definition.
The case was tossed out of court as it should be, but if you are of childbearing age and this doesn't freak you the fuck out, you're not paying attention.
Beltran is suing the crap out of the state - and she's going to win. We can only imagine how many other women have been held without representation for similar charges who did not have the wherewithal to fight back since 1997.
Let us just remember that when folks like the Oathkeepers, the teabillies and FEMA camp truthers say they will resist any and all impingement on personal freedom - they are liars, cowards and full of shit.
If a Republican proposed it and the right to lifers support it - they are more than willing to look the other way no matter how egregious the over-reach.
The only freedom they care about is their own.


Check out what all the hype is about.
NY DAILY NEWS
...and some more chicken!
Take a lesson
With Professor Formisano
“God gives every one of us a gift,” observes Carlo Formisano. “Let’s just say that giving people the best chicken around is our special gift.” During his 24 years as manager of the La Pera Brothers live poultry market in Bensonhurst, Formisano has attracted new waves of immigrants and kept the loyalists coming back for more. Many of the groups he serves are just as passionate about quality and freshness as he is.
Brooklyn shoppers are flocking - pardon the pun - to live poultry markets to purchase turkeys and other freshly-slaughtered fowl for Thanksgiving dinner tables.
In the run-up to Thursday’s holiday, 80-some live poultry markets citywide are enjoying a moment in the limelight, drawing the attention of foodies and traditionalists who buy killed-to-order birds only for Thanksgiving.
“It’s fair to call it our Super Bowl,” said Carlo Formisano, manager of La Pera Brothers.
Carlo Formisano is the face of La Pera Brothers Poultry, an all natural poultry market located in Bensonhurst, Brooklyn. For the past 25 years, Carlo has been sourcing and selling fresh poultry to New Yorkers seeking a fresh alternative to supermarket poultry. Some of New York City's top restaurants and chefs, including Daniel and Megu source their poultry from Carlo.
Every Brooklynite has a discount card for his friendly neighborhood coffee shop — buy 10 coffees, get one free. Finally, this vital customer service has come to live poultry.
“I got customers that come everyday, so I wanted to make it fair for them,” said Carlo Formisano, the manager of La Pera Brothers live poultry market in Dyker Heights.
The punchcard gimmick is limited to chickens, but customers will find plenty of other animals ripe for the picking: Quail, pigeons, lamb, goats, rabbits and turkey.
he 53-year-old La Pera Brothers is not for the sensitive carnivore, but it is for anyone looking for truly fresh meat (the slaughtered animal flesh is still warm as you carry it out to your car).
Mr. Kim said in an e-mail. “It comes to us warm, though, and the texture of the chickens, even at its raw phase, is something remarkable.”
Carlo Formisano, the manager at La Pera Brothers Poultry, the Borough Park company that kills and cleans the chickens, explained to us that after the frigid, blood-draining bath, the chickens are also given a quick exposure to boiling water as part of the process of plucking their feathers.
I’ve always believed in freshness,” Mr. Formisano said. “I don’t eat at restaurants that don’t serve my products.”
So what does one first notice about a delivery of “Fresh Killed Chicken,” when the birds first arrive at a restaurant? As Mr. Kim put it, “Their body temperature is still warm.”


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The Legacy of Lost Things, the debut novel from writer Aida Zilelian, is a subtle testament to the ways we erase the identity of those closest to us, and the ways we allow our identities to be erased. By exploring one family’s history of internalized suffering, Zilelian reminds us all of the importance for individualization in tradition.
The many-layered and faceted nature of legacy unfolds in a series of chapters that leap between characters and generations, reaching back into the past before snapping forward to the present. Having created a rigid picture of a family in crisis, Zilelian peels back the layers to reveal decades of repressed dreams and loves, each sacrificed in the name of family and tradition. The ties that bind these close-knit characters together read like cutting zip ties than tethering captives to a destiny they had no hand in choosing.
When teenager Araxi runs away from home, she leaves behind her mother, father, and younger sister.
Over the course of three months, the absence of their eldest daughter weighs on Levon and Tamar, Armenian immigrants who moved to New York City as children and quickly became folded into the Armenian community in their new city. Faced with an act of intense rebellion, they reflect on their own youthful desires, all of which they eventually put aside in favor of what they saw as their unchangeable fate. Meanwhile, Sophie finds herself torn between the rigidity of life in her family’s home and the total rejection of it that Araxi’s leaving signifies. Half a country away, Araxi asks herself much the same questions from the other side of the divide.
The silence of the book is palpable, as each generation passes down to the next an unbroken history of longing suffered quietly. Tamar’s love for a boy she has known since childhood weighs heavily on her, but is not enough to draw her away from the life she sees as non-negotiable. Levon fears his eldest daughter is not his, and allows his pain to fuel anger towards his depressed wife. Tamar was once rebellious, willing to push gently against the envelope. Levon once feared his cruel, temperamental father. Both of them now find themselves filling the roles that once made them feel so trapped, boxing their daughters into the same tight cages that left them stemmied and unfulfilled.
But Araxi’s leaving forces their eyes and hearts open in a way they had previously not allowed. By breaking through the cycle that has caused such personal loss for so many, Araxi has given her family the opportunity to rebuild on a foundation of honesty, even if that honesty is forged in pain.
The Legacy of Lost Things is an at times chilling meditation on the heritage we don’t choose to pass down, and on the power of generational expectations. Despite physical closeness and insularity, Araxi’s family is distant and strangers to one another, a haunting reminder of the gaps in understanding that can take on their own life in the absence of true connection. Zilelian’s debut novel is a breathtaking look at the canyons between families, and the way loss can be passed from generation to generation.
Bridey Heing is a freelance writer living in Washington, D.C. Her interests include travel, international politics, film, and tattoos. More of her work can be seen here.


Scale(Geometry, Double, Double, MapPoint)
Scales the given geometry by the specified factors from the specified origin point.
public static Geometry Scale(this Geometry geometry, double scaleX, double scaleY, MapPoint origin = null)
The geometry to scale.
The scale factor along the x-axis. It can be positive or negative. It cannot be a non-numeric value.
The scale factor along the y-axis. It can be positive or negative. It cannot be a non-numeric value.
The point around which the geometry will be scaled. If
A new geometry constructed by scaling the input geometry by the specified factors from the specified origin point.
origin has a different SpatialReference than that of the
the point will be reprojected before the geometry is scaled, using the default transformation.
Positive scale factors greater than 1 increase the size of the
geometry, and positive
factors between 0 and 1 reduce the size of the geometry. 0 or negative scale factors produce a geometry reflected
across the axes of the origin point. Negative factors less than -1 both reflect and increase the size of the
geometry, and negative factors between -1 and 0 both reflect and reduce the size of the geometry. Scale
factors of -1 reflect the geometry across the axes of the origin point without changing the size.
Supports true curves.
Platforms and versions
|.NET Standard 2.0||200.3|


text:
Team Spirit On Display Again For Fonte
Match winning defender Jose Fonte has said that our victory over Hull City last night shows the team spirit that has been a topic of news when it comes to Southampton over the last few weeks.
Fonte not only put in a good defensive display along with the rest of the lads, but he also found the all important goal on 69 minutes and although it was a scrappy, scrambled effort, they all count and that one counted for all three points.
Speaking to saintsfc Fonte said that Hull were one of the toughest tests we will face this season, so to come through it with flying colours is a just desert for everyone.
'They're a very good team and we have a lot of respect for Steve Bruce and the way he set the team up. We knew it was going to be one of the hardest games of our season. But we dug deep and I think we showed a lot of character, desire and belief. We got our reward with the three points and a very important clean sheet.'
As for his direct impact on achieving those three points Fonte says very humbly that basically he was just in the right place at the right time, and he was pleased to be able to help out the team and his colleagues at the other end of the pitch and help us take the win, because all that matters is how we keep pushing on in the remainder of this season now, and we have now got our noses in front of Newcastle and are closer to that higher pack of teams which is where we want to be.
Whatever happens in the Newcastle game tonight, we are closer than we were this time last week, and that is what counts.
Fonte ended his interview by heaping praise on fellow centre half, Maya Yoshida, for his efforts and performances in the team after he replaced the injured Dejan Lovren.
'I thought Maya was excellent. He was strong and good in the air, he was faultless. When you don't play in consecutive games it's hard to come into the team and do well, and it's very important for him and his ambitions to play in the World Cup that he plays so I'm happy for him. He's helping the team do well.'
A third game against Sunderland this season now beckons, and Fonte is under no illusions as to what it would mean to have another trip to Wembley and win the FA Cup for both the players and the fans, and that will now be the aim as we look to take our league form back into the historic domestic cup competition.
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text:
Mazars, the integrated and independent international organisation specialising in audit, accountancy, tax and consulting services, has been awarded the Top 50 Tax Team of the Year award at the 2016 British Accountancy Awards.
The awards ceremony took place on Tuesday 29 November at The Brewery on Chiswell Street in London.The judging panel recognised, in particular, that the team from Mazars “looks to deal with the major challenges of delivering a modern-day tax service, that of transparency and ethics. Alongside their approach (the team) also illustrated their success with impressive figures.”
Tim Davies, partner and UK Head of Tax at Mazars, commented: “On behalf of the team, we are delighted to have won this award. To be recognised for our thought leadership, commitment to clients, innovation and growth is true testament to our culture and commitment, as well as our expertise.”
Senior Partner of Mazars UK, Phil Verity, continued: “Tax has always been an area that Mazars is known for. Tim and the rest of our UK tax team continuously work hard to deliver our services in a positively different way. A way that supports our clients and adds value, considers the specific needs of their businesses and the sectors in which they operate, and is reflective of immediate and long-term changing market conditions. This award is very much deserved.”
Mazars was also nominated for the National Team of the Year category at the British Accountancy Awards, having won the previous year in 2015.