Saturday, April 10, 2010
El Clasico – Who will reign in Spain? Real Madrid or Barcelona ?The two teams clash at the Santiago Bernabeu to decide the title victor's
The problem, of course, is that both players were dumped after being considered surplus to requirements at the Santiago Bernabeu just before the start of the season.
So, while Perez got his wish back in the summer of 2009 with the annual player movement in-and-out of Madrid, it was his counterpart from Barcelona who carried the hopes of Spain into the CL semi-finals this year.
That contrast will come to play tonight (Sunday, 4am) as the two giants of Spanish football meet at the Bernabeu in the latest edition of the biggest derby in the world, outside of England.
Even if for some strange reason, you forgot that it was the Lionel Messi-Cristiano Ronaldo duel, it will still be a highly entertaining game of Spanish football for all football aficionados.
It is rare that a player thumping in 25 goals in a season so far can still be considered yesterday’s news, but that is how one can describe Ronaldo compared with the abundant accolades showered on Messi in recent weeks.
That’s not to say that the Portuguese has not performed admirably in his first year in La Liga. It is just that the magic of Messi on the pitch adds to the mystery of the contrast in personalities of the two players, making it a case of the simple street kid versus the spoilt superstar.
Ironically, the two clubs’ rivalry originated from non-football related issues, or to be more precise, a political one. Madrid and Barcelona are the two largest cities in Spain, and they are often identified with “Spanishness” and Catalanism, respectively, whilst the clubs are the most successful and influential football clubs in the country.
The enmity between the historic rivals spiralled from the moment in 1953 when Argentine-born legend, Alfredo Di Stefano, controversially signed for Los Merengues after initially agreeing to join Barca. The Catalans claimed dictator General Franco tipped the balance Real’s way.
Di Stefano went on to help Madrid to the first five European Cups and eight Liga titles, forming the bedrock of the club’s grand status within world football.
The rivalry has also been heightened many times over by Real Madrid and Barcelona top players defecting to their arch-rival. Notable Barcelona players who have taken the “Puente Aereo” to Real Madrid include Bernd Schuster (1988), Michael Laudrup (1994) and Luís Figo (2000). Luis Enrique switched from Real Madrid to Barcelona in 1996 and went on to captain the Blaugrana.
The clubs are, quite simply, obsessed with each other. The media is happy to build it up – it sells millions of papers – and fans around the world are fascinated by one of the most ferocious derbies in football, despite the 630km that separate the rival cities!
When Barcelona swept all before them last season, Real responded by spending a fortune on the best players in the world. Barca countered the arrivals of Ronaldo, Kaka, Karim Benzema and Xabi Alonso by bringing in their own marquee signing Zlatan Ibrahimovic, even though it meant parting with €40 million (RM172 million) and Samuel Eto’o. They had to be seen to be doing something.
Barcelona come into this match in full confidence after dissecting Arsenal in the mid-week second leg quarterfinal Champions League tie. And they owe it all to one man.
It is getting increasingly difficult not to resort to hyperbole when describing the feats of Messi. However, fair judgement should be withheld until after the 2010 World Cup in South Africa this summer, when the 22-year-old will carry the hopes of Argentina.
If Messi can still perform then as he does for Barcelona, he truly will rank alongside Pele, Di Stefano, Johan Cruyff and Diego Maradona.
Still, he sits below his compatriot, Maradona. The footballing legend and current national team coach was not only the maestro in successful teams — Napoli, Barcelona and Argentina — but Maradona also was the team.
Of recent greats, Messi seems to be even under the shadow of Zinédine Zidane, in that Messi does not aspire to be the conductor of his side, but simply the dazzling virtuoso.
That said, Messi has been in stunning form this season and took his tally for the campaign to 39 goals in all competitions with all four in Tuesday’s 4-1 win over a much-weakened Arsenal line-up.
Ronaldo has added to the growing list of plaudits for Barcelona superstar Messi, but warned it would be a mistake for Real Madrid to concentrate only on the Argentinian playmaker in this weekend’s “El Clasico”.
Messi has scored 15 goals in his last 10 games, including three hat-tricks, and is only going to be one of the major figures tonight.
“He’s phenomenal, but Messi doesn’t play on his own. The coach and his team-mates deserve credit as well. Whoever knows about football knows what I’m saying,” Ronaldo added.
Last year, the Madrid side attempted to kick him off the ball with some shockingly blatant fouls, but Messi has proven himself capable of fending off such treatment. Give him space to run at defenders and his goal tally of 37 in 42 games this season will surely increase.
Barca makes the trip to Madrid this weekend with both clubs locked on 77 points. In a league that is decided on a head-to-head record rather than goal difference in the result of a tie, it is imperative for Real Madrid to pick up the three points and overturn the 1-0 deficit from last November’s clash at the Nou Camp.
Besides Messi, there is another Argentinian who has been bagging the goals in the Primera Liga. He is Gonzalo Higuain and the only thing keeping him from the spotlight is the star-studded line-up Real Madrid possess.
The 22-year-old took his tally of goals to 24 for the season during last weekend’s 2-0 win over Racing Santander, and he is now just two behind Messi at the top of the Spanish league scoring charts.
Real are also sweating on the fitness of maestro Kaka who looks to be in danger of missing out on the tie as he has been struggling to deal with a hernia injury the past month. His participation remains in severe doubt, with Rafael van der Vaart set to deputise once again should he fail to make it.
Benzema is still not 100 per cent fit, despite returning to training, and Christoph Metzelder still has nightmares about the 6-2 drubbing last season.
Barca, on the other hand, will be missing Eric Abidal after he aggravated his thigh injury against Arsenal. Gerard Pique and Zlatan Ibrahimovic are both struggling to be fit.
Pep Guardiola’s men have won their last three meetings against Real Madrid, netting an average of three goals per game, but Manuel Pellegrini’s side are on a run of 12 consecutive league wins, and have notched-up 15 wins in a row at home, so they won’t be pushovers. They have also netted 83 goals in total – eight more than Barca.
However, Madrid were in similarly good form going into last season’s corresponding fixture, which was also a vital game in the title race but ended up being one of the most painful in the club’s illustrious history.
Over the last five seasons Real Madrid have only emerged victors once, in December 2007. They even did the double on Barca that season.
Real Madrid have found this particular manifestation of Barça rather hard to take, especially given the 6-2 defeat of last season.
No doubt, some measure of revenge will go a long way towards wiping away the humiliation at the Bernabeu last season, or at the least, wrest back some dignity.
With Real having to go all out in this match to secure a win for reasons I have mentioned above, I can see Perez having the last laugh watching the match from his presidential box at the stadium tonight. A narrow win is on the cards for the home side.


As you should Atlanta FX is headed back to The Emmys this year with a couple nominations. In a new interview with ‘The Hollywood Reporter’, writer of the series, Stephen Glover, would discuss his favorite moments from the show’s second season. For Glover, he would go on to tell THR that his personal favorite dialogue was when barber Bibby (played by comedian Robert Powell) kept confusing character Al in the barbershop when he was on his Bluetooth.
THR: What would you say is one of your favorite lines of dialogue?
The whole opening scene of the barbershop episode where Bibby and Al are in the barbershop and he is trying to get his hair cut and Bibby won’t even start. Alfred thinks he’s talking to him but he’s on the phone, then Bibby is talking to him — he can’t tell because he has a bluetooth phone. Alfred is like, “I have somewhere to be,” and Bibby’s like, “What are you hanging around for, don’t you have somewhere to be?” and Al’s like, “Yes! I already told you that!” It’s very Atlanta and very specific to my life.
Watch the moment, below.


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domain: artistic


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BALTIMORE (WJZ) — Bank of America is planning to add about 600 new jobs at its complex in Baltimore County.
This comes after adding nearly 300 jobs in 2017. Bank of America also plans to bring a total of about 1,500 jobs to its Hunt Valley campus by 2020.
“We are pleased to expand our base of operations in Baltimore County and the great state of Maryland, and we are appreciative of our public servants who work tirelessly on behalf of the community we are proud to serve,” said Bank of America Greater Maryland Market President Sabina Kelly.
The new jobs will be mostly call center and staff support positions.


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- CelebrityCountry Living
"My hot girl summer."
- U.S.TCPalm | Treasure Coast Newspapers
Is there a sawfish nursery in the river? The latest sighting brings this year's total to over a dozen, according to Florida wildlife biologists.
- EntertainmentThe Hollywood Reporter
- LifestyleIn The Know by Yahoo
Shoppers say this $4 foot cream on Amazon is the best for healing dry, cracked feet fast: 'This stuff is amazing'
Grab a jar to get your feet ready for sandals season.
For five decades Dean Fidelmen has been Yosemite's artistic don. But he's still evolving. Now, after a three-year hiatus, he's bringing his Stone Nudes calendar back. With some twists.
- CelebrityGood Housekeeping
'Flight Attendant' and 'Big Bang Theory' actress Kaley Cuoco caused reactions when fans saw a throwback photo of her wearing a red dress on Instagram. Look at the pictures and read what people had to say about it.
The fast-food chain teased its biggest fans on Twitter, but now it has actually brought back a much-requested item.

domain: entertainment


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One of nature's most celebrated creations is the simple sand dollar. It’s a reminder of fond memories at the beach with family and friends. So delicate yet strong enough to survive heavy surf and changing tides. Sterling silver with enamel inlay.
Sterling silver with a yellow gold vermeil inlay. On the back, “My heart is in the sands.”
The pendant comes in three sizes:
Medium (27mm), Small (19mm), Mini (15mm)
Complete the look with a LOLA Signature Rolo Chain.

domain: design


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Books & Music
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Hobbies & Crafts
Home & Garden
News & Politics
Religion & Spirituality
Travel & Culture
TV & Movies
Archive by Article Title | Archive by Date
Let’s Take a Closer Look at Ginko Biloba
At Maryland’s School of Pharmacy research is being conducted to either validate or refute the theory that the extract of ginkgo biloba leaves can at best prevent or at least delay the symptoms of Alzheimer’s disease.
Lipitor May Be Good For Alzheimer's
The cholesterol-lowering drug, Lipitor, may be good for the brain. The latest research suggests that high doses of Lipitor can slow the progression of Alzheimer´s disease.
Living in the Moment with Alzheimer’s
Alzheimer’s is a disease about letting go of resentment and anger. You get a fresh start every moment. We can all learn to live in the moment.
Living with A Loved One
Dear Debbie, I need your help!!! My mother is driving me and the children crazy. Not only is she forgetful, but she is paranoid and always accusing me of not loving her. I feel like the madness is contagious.
Living with Alzheimer’s Disease
A couple of years ago I wrote about my friend Claire describing her as an inspirational example of someone “living gracefully” with Alzheimer’s disease. It has now been over a decade and here is what I learned by observing her:
Loneliness Linked to Alzheimer’s
People who feel isolated and unsupported are more prone to dementia. The take home message: Get out there and mingle.
Long Distance Caregiving
If you are a caregiver from a distance for an Alzheimer’s patient, whether this means the patient is being taken care of at home by another family member, a live-in companion or at a nursing home, you will feel guilty.How do you connect and supervise? How do you help those bearing the brunt?
Maria Shriver Advocates for Alzheimer’s
Alzheimer’s disease is in the spotlight with a new celebrity, Maria Shriver, who has come forward to advocate for disease sufferers including their families. Also, recent advances in Alzheimer´s research.
Mind Your Muscle
Many children of Alzheimer’s patients fear a genetic link. It is hard to do nothing proactive to prevent the onset of the disease. Research studies claim that exercise is more beneficial than cross word puzzles.
Namenda - A New Drug On The Horizon
Namenda, a new drug, shows promise for moderate to late stages of Alzheimer´s.
Website copyright © 2013 Minerva WebWorks LLC. All rights reserved.

domain: medical


New Digital Roads Data Set Characterizes Intercity Road Networks Around the World
CIESIN has released a digital global data set on intercity roads, the Global Roads Open Access Data Set, Version 1 (gROADSv1). Developed under the auspices of the Global Roads Data Development Task Group of the Committee on Data for Science and Technology (CODATA) of the International Council for Science, gROADSv1 combines the best available open access data on roads between human settlements into a global roads coverage consistent with the United Nations Spatial Data Infrastructure Transport (UNSDI-T) version 2 data model.
This first version of the gROADS data set is part of a continuing effort to address the need among professionals in the humanitarian response, development, transportation, biodiversity conservation, and allied fields for free and open, spatially accurate, and readily updateable data on roads in order to better understand issues such as market access, cost of transportation, and human pressures on the environment. Data on road networks connecting human settlements may be especially valuable when used in conjunction with remote sensing and other spatial data to improve decision making related to urbanization and rural development. gROADSv1 is being distributed by the NASA Socioeconomic Data and Applications Center (SEDAC) operated by CIESIN, and represents an important step towards addressing the criteria established by the CODATA Task Group.
See: Global Roads Open Access Data Set, Version 1 (gROADSv1)


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Discussion in 'Your Fun 'n Games Room' started by Bergie, Sep 26, 2006.
(Get some sleep dear one!)
(Ok not really I'm at work now playing on internet and watching movies on Computer)LOL
(at the ) DISCO ;D ;D ;D
Hi gwen.. ..it's jayC...
(anyone remember that song! Jive Talkin')
Hi jayC 8)

domain: hobby


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Serum is frequently added to defined basal media as a source of certain nutrients and macromolecular growth factors essential for cell growth. The many different sera commercially available may not be equally suitable for all cell types. The effects of four sera, fetal bovine serum (FBS), calf bovine serum (CS), equine serum (ES-1), and plasma-derived equine serum (ES-2), on growth and permeability properties of cultured porcine endothelial cells were determined. The rate of DNA synthesis, measured as [3H]thymidine incorporation, reached a peak at around 24 h, regardless of serum type, and was most marked with ES-1- or ES-2-treated cells. However, when estimated by total DNA, FBS, CS, or ES-1 treatment resulted in greater cell proliferation than ES-2. Based on protein synthetic rate and total cell protein, both FBS and CS appeared to be most growth supporting. At 72 h after cell plating, albumin passage across cultured endothelial monolayers was elevated in ES-1- and ES-2-treated cells compared with FBS- or CS-treated cells. "Leaky" cell monolayers were most marked with ES-1-treated cells. Cells grown in ES-2- and particularly in ES-1-enriched media were larger and more spindle-shaped compared with the typical cobblestone appearance of cells cultured in media enriched with either FBS or CS. These data suggest that CS, but not ES-1 or ES-2, is an excellent substitute for FBS to support desirable growth properties of macrovascular endothelial cells in culture.
|Number of pages||8|
|Journal||Experimental Cell Research|
|State||Published - Apr 1989|
Bibliographical noteFunding Information:
Supported in part by Grant HL 34423 from the National Heart, Lung, and Blood Institute, National Institutes of Health; a grant from the American Heart Association, Kentucky Affiliate; and the Kentucky Agricultural Experiment Station. We appreciate the helpful suggestions provided by anonymous reviewers of the manuscript.
ASJC Scopus subject areas
- Cell Biology

domain: literature


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Do not take this medication if you are allergic to oxcarbazepine or to a similar medicine called carbamazepine (Carbatrol, Tegretol).
Before taking oxcarbazepine, tell your doctor if you have liver or kidney disease.
Do not use this medication without your doctor’s consent if you are pregnant. It could cause harm to the unborn baby. Oxcarbazepine should not be used during pregnancy, but taking the medicine can make birth control pills less effective. Use a non-hormone method of birth control (not birth control pills) to prevent pregnancy while you are taking oxcarbazepine. Tell your doctor if you become pregnant during treatment.
Oxcarbazepine can reduce the sodium in your body to dangerously low levels, which can cause a life-threatening electrolyte imbalance. Contact your doctor right away if you have nausea with vomiting, weakness, headache, confusion, mood changes, and/or increased or more severe seizures.
You may have thoughts about suicide while taking this medication. Your doctor will need to check you at regular visits. Do not miss any scheduled appointments.
Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, depression, anxiety, or if you feel agitated, hostile, restless, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself.
There are many other medicines that can interact with oxcarbazepine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.


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Are Alternative Investments Right for You?
With alternative investments, it’s critical to sort through the complexity.
Have A Question About This Topic?
Things to consider before retirement.
When to start? Should I continue to work? How can I maximize my benefit?
Five strategies for managing your student debt.

domain: economics


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text: Hey there! I have a few game hens and the colour thing is really confusing me. I have a pair of red pyles and the chicks that I got are both white (from what I can tell). I was expecting red pyles (not a big deal just not what I thought. Will they get the colour as they age? They're about 4 weeks old now. Also if I crossed a red pyle roo with a self blue or black tailed Jap hen, what colour will the chicks be? Thanks guys!!

domain: pet


Bliss Home Theaters and Automation, Inc has been creating and installing custom home theatres and automation systems since 1994, its key mission being to provide turnkey custom home theatres and automation systems for its clients.
The family owned and operated business prides itself on customer service, close customer relationships and professionalism.
Robert and George Bliss personally interact with all clientele through the entire process, from design to delivery of the custom system.
Typically, the company’s jobs range from $250K for a dedicated home theatre system to north of $US12 million for the ultimate automation system.
A recent project saw the team install a consumer grade theatre with ‘some professional perks’ into a brand new French chateau estate in Calabasas, California.
“Bliss HTA has the expertise to handle any project from small to immense,” says Robert. “Our system is one of the largest selling points, if not the selling point, after our customers put their home on the market.”
Bliss is a referral-based business and relies on complete satisfaction from its clients. “We as a team will go to any lengths to ensure a satisfied customer and a positive referral,” he clarifies.
The theatre boasts 16 zones of audio, video and HVAC.
Plush seating is provided for in the way of Fortress Seating motorised reclining models.
“The entire project is Crestron,” says Robert. “Crestron DM is the video switch and Crestron Swamp is used for audio. Every zone is controlled by either a hand-held Crestron MLX-3 or an iPad mini. Lighting, shades, security, pool and surveillance is also all provided by, or controlled by Crestron.
“In our opinion Crestron is the only product to use. Everything else is second place,” he states.”
Robert reveals that the team didn’t face any challenges during the installation as the project was planned and executed with realistic expectations in mind.
When asked if anything stood out for him, Robert comments that the “background music system is above average; it had to perform at an elevated level. We used Meyer Sound and it really came out really nicely. However the theatre is my personal favourite part because they are fun to do.”
And the client’s favourite part of the finished install…? “You will laugh; but it’s his speakers in the master shower!”


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A collection of loyal poems satyrs and lampoons
Beinecke Rare Book and Manuscript Library > A collection of loyal poems satyrs and lampoons
- A collection of loyal poems satyrs and lampoons
- Published / Created
- [ca. 1695?]
Manuscript, in a single hand, of a collection of 239 political poems expressing loyalty to James II and entreaties for him to resume the English throne. Titles of such poems include His majestie's royal farewell to England and The confinement by Sir Robert L'Estrange. Other entries consist of songs in praise of King James, including A health to the King's return; A song to the tune of the King shall enjoy his own again; and A loyal Jacobean song. Many other poems lampoon or eulogize specific figures, such as Elegy on Mr. Ashton; An acrostic on John Tillotson; and an Epitaph on Algernon Sidney. Numerous poems mock the figures of William and Mary, including On the coronation of K. William and Q. Mary; and On the late metamorphosis of an old picture of Oliver Cromwells into a new picture of King William, the head chang'd the hierogliphicks remaining; others satirize the Protestant Church, Parliament, the Church of England, and the nonjuror controversy that followed the Revolution of 1688.
Binding: contemporary red morocco; gilt decoration. In gilt on cover: the arms of King James II, to whom the manuscript was presented about 1700. Title on spine: "Loyal Poems &c."
Formerly owned by Sir Thomas Strange. On flyleaf: T. A. W. L. Strange.
Pasted on flyleaf: dealer's description of manuscript.
Table of contents at beginning of manuscript, and index at end.
Title from title page.
- 1 v. (596 p.), plus index. One leaf missing p. 367-8 ; 21 cm.
- Extent of Digitization
- Completely digitized
- Beinecke Rare Book and Manuscript Library
- Call Number
- Osborn b111
Subjects, Formats, And Genres
- Subject (Geographic)
Great Britain--History--Revolution of 1688
Great Britain--Politics and government--1660-1714
- Subject (Name)
Great Britain.--Parliament |d (1689)
James--II,--King of England,--1633-1701
Mary II, Queen of England, 1662-1694
Russell, Archibald George Blomefield, 1879-1955
William--III,--King of England,--1650-1702
- Subject (Topic)
English poetry--17th century
English wit and humor
Political poetry, English--Early modern, 1500-1700
Verse satire, English
Access And Usage Rights
- The use of this image may be subject to the copyright law of the United States (Title 17, United States Code) or to site license or other rights management terms and conditions. The person using the image is liable for any infringement.
- A Collection of Loyal Poems Satyrs and Lampoons. James Marshall and Marie-Louise Osborn Collection, Beinecke Rare Book and Manuscript Library, Yale University.
- Orbis Record
- Object ID (OID)

domain: library


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On Monday, Shares of Cisco Systems, Inc. (NASDAQ:CSCO), remain flat and closed at $31.47 in the last trading session. The last trading range of the stock ranges between $31.44 and $31.68. The company’s Market capitalization is $157.75 Billion with the total Outstanding Shares of 5.03 Billion. During the 52-week trading session the minimum price at which share price traded, registered at $22.46 and reached to max level of $31.95. Celestica Inc. (CLS) (CLS), a global leader in the delivery of end-to-end product lifecycle solutions, recently declared that it has received the 2016 Excellence in Sustainability award from Cisco®.
This prestigious award recognizes Celestica for Excellence in Sustainability for demonstrating sustainability leadership above and beyond standard sustainability practices, and leading the industry through its approaches to reduce negative environmental impacts and raise positive social impacts. The distinction was awarded during Cisco’s 25th Annual Supplier Appreciation Event, held September 8 at the Santa Clara Convention Center in California.
“The theme for our Silver Anniversary SAE event, ‘Celebrating the Journey’, puts the spotlight on our continued journey towards Digitization and the tremendous opportunities that come from connecting people, processes, data and things,” said John Kern, senior vice president, Supply Chain Operations, Cisco. “Cisco’s supply chain has evolved into the recognized leader it is recently with suppliers and partners playing an instrumental role in the company’s growth, development and success. We’ve come a long way, but we must continue to evolve, innovate and accelerate.”
Hecla Mining Company (NYSE:HL), jumped 0.57% and closed at $5.27 in the last trading session. The last trading range of the stock ranges between $5.26 and $5.43. The company’s Market capitalization is $2.11 Billion with the total Outstanding Shares of 395.48 million. During the 52-week trading session the minimum price at which share price traded, registered at $1.45 and reached to max level of $7.26. Hecla Mining Company, together with its auxiliaries, discovers, acquires, develops, produces, and markets precious and base metal deposits worldwide. The company offers unrefined gold and silver bullion bars to precious metals traders; and lead, zinc, and bulk concentrates to custom smelters and brokers. It owns 100% interests in the Greens Creek mine located on Admiralty Island in Southeast Alaska; the Lucky Friday unit located in the Coeur dAlene mining district in northern Idaho; the Casa Berardi mine located in the Abitibi region of north-western Quebec, Canada; and the San Sebastian unit located in the state of Durango, Mexico.

domain: finance


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A biotech analyst could play it safe, and stick with mid-, late- and commercial-stage companies that offer higher odds and decent returns on good news.
The Life Sciences Report: Chris, small molecules will always be an important part of medicine. But now we are seeing therapeutic interventions move to new paradigms, with larger molecules such as antibodies and fusion proteins, and soon we'll see wider use of regenerative and immunologically enhanced cells, as well as oligonucleotides--small segments of DNA and RNA. It's hard to discern how clinicians will embrace these newer therapies. How do investors get their arms around these concepts? How do we know that some of these ideas won't be the eight-track tapes of tomorrow?
That being said, I do believe that pharmas and investors are increasingly interested in larger molecules, in RNA-based therapies, and in regenerative approaches such as stem cells, which have the ability to actually modify disease, versus a small molecule that must be used chronically, for long term. The newer modalities offer the right combination of technology and intellectual property (IP), and are attracting the investment capital to advance. These potentially very powerful medicines can help patients with diseases that represent truly unmet needs. They also offer a potentially faster path to approval--especially for orphan disease indications.
TLSR: A physician can write a prescription for any approved small molecule. Any patient can carry these pills on his/her person. Plain and simple, they are modular. Newer therapies may break that model, resulting in slower uptake. I'll give you an example: Rheumatologists have been slow to embrace B-cell blockade with antibodies for autoimmune disease--psoriatic arthritis, rheumatoid arthritis, etc.--because they think of these infusions as chemotherapeutic agents. Infusions of large molecules don't traditionally fit into the rheumatologist's practice model. Do we just assume that newer modalities, such as stem cells and oligonucleotides, are going to encounter slow uptake?
CJ: Let's take a step back. You mentioned oligonucleotide therapies; these include antisense, RNA interference (RNAi) and approaches to target microRNAs. These therapies offer a unique opportunity to target a range of diseases that cannot be addressed with traditional, small-molecule pills. I believe that once the data are mature, the potential for targeting diseases with oligonucleotides will be recognized as unique and huge.
You can target microRNAs to control gene expression and entire pathways of diseases. It's a very powerful technology.
TLSR: You initiated coverage on Regulus in mid-May of this year. The company was formed as a joint venture of
CJ: Yes. We believe Regulus is on the forefront of the movement away from monogenetic disorders and toward targeting entire pathways. The microRNAs that Regulus targets are extraordinarily powerful, and can regulate networks that play a major role in biological processes such as immune modulation, metabolic disease and neurological disease. The company's technology is differentiated because microRNAs work farther upstream than either antisense or RNAi, which both target only single genes.
Regulus has large pharma alliances, which lower the risk and validate its microRNA technology platform. The company recently renewed a strategic alliance with
TLSR: The company's market cap is almost
CJ: Regulus actually does have a molecule in the clinic. It is RG-101 (targeting microRNA-122 [miR-122]) in a 100-patient Phase 1 study that includes both healthy and HCV-infected patients in
TLSR: Chris, allow me to go back to RG-101 for HCV for a moment. Is that a
CJ: It's not a U.S. study, and if the study is not being conducted in the U.S., it does not have to be in the clinicaltrials.gov database. We don't believe that will affect the drug moving forward. The study is being done in
RG-101 is targeting miR-122, which is one of the most highly conserved (by evolution) regions encompassing all HCV genotypes. RG-101 is pan-genotypic in its scope, which would include HCV genotype 3.
TLSR: To your point about partnering, both Alnylam and Isis have created business models where they achieve proof of concept in targeting genes, and then partner their products with companies that have expertise in marketing to that disease indication. Does this appear to be what Regulus is doing?
CJ: Yes, absolutely. I'll remind you that in January, Alnylam entered into a large strategic alliance with
TLSR: You have a new company under coverage. Could you tell me about it?
TLSR: Give me your investment theory on
CJ: This company is rapidly advancing a neural stem cell therapy for multiple indications, particularly for the central nervous system. It is going after chronic spinal cord injury (SCI) and geographic atrophy age-related macular degeneration (GA-AMD). Both indications, we think, will generate significant data over the next 24 months.
TLSR: These two indications are the catalysts for
CJ: The main catalyst right now is GA-AMD. Investors like this story because of their familiarity with
Recently, we saw initial interim data from the Phase 1/2 study with the company's HuCNS-SC cells (purified adult human neural cells of fetal origin) in GA-AMD. These data were extraordinarily encouraging. In fact, when you compare them to Phase 2 data from
We will see additional data from this
TLSR: Going back to spinal cord injury, loss of motor function is a difficult indication, and that really gets people's attention. I'm wondering why
CJ: That's a great point, which I can address from a clinically practical standpoint. There is a large commercial opportunity with spinal cord injury, but a real, practical problem with treating acute injury patients.
As you mentioned, the microenvironment changes over time. There is glial scarring, and the disease process changes. Treating the acute form of spinal cord injury does offer patients the best possible outcomes. The problem is that you are treating a patient who was fine up until a motorcycle or car accident. Suddenly he can't feel a certain part of his body--or, God forbid, he may have a high cervical injury, with paralysis from neck down. It's hard to convince this patient that he is not going to walk again for the rest of his life. Can you imagine the conversation at the bedside? Can you say to this patient: "You are not going to walk again, and we need you to accept that. We also need you to accept an experimental therapy."?
Treating the acute-injury patient is a very delicate situation. Patient acceptance of the true situation may be six months in the future. But a therapy would be more efficacious earlier than later. This opportunity will come eventually, after good data and proof of concept have been generated.
TLSR: What kind of improvements have we seen in spinal cord injury with
CJ: We have seen improvements in sensation at the thoracic level. Thoracic injuries are much worse than cervical injuries. You need greater trauma to affect the thoracic cord versus the cervical cord, where very small amounts of trauma can cause problems. Cervical cord is much more delicate and controls more motor function. To show improvement in a difficult area like thoracic cord bodes well for the next phase, which will start later this year and focus on cervical injury. You need less improvement in the cervical cord to regain movement--actual motor function. We think the thoracic data will translate to increased efficacy at the cervical level and the presence of small motor improvements, such as allowing movement in the hands--maybe to control an electric wheelchair, maybe to type--that would really affect quality of life. These commercial opportunities will propel the company's valuation higher.
TLSR: Chris, could you mention another name?
CJ: We are very excited about
We're particularly excited about Rexahn's RNA-based therapeutic, an oligonucleotide. This class of drug is coming of age. The Archexin Phase 2a proof-of-concept trial in metastatic renal cell carcinoma is enrolling patients. It also has orphan drug designation.
TLSR: Do all of those programs have data forthcoming that could move this stock over the next year?
CJ: We should have some safety data from the Archexin study in Q4/14. The company recently provided an update on its Phase 1 supinoxin trial in cancer patients. Enrollment with the fourth dose is complete, and the estimated bioavailability is approximately 50%. Complete enrollment is on track for Q4/14. With RX-3117, we also expect a Phase 1 study to be completed in Q4/14.
TLSR: Thank you, Chris.
CJ: Thanks so much.
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The main Man: City want £17m-rated Porto defender Mangala in summer
Manchester City have added Porto defender Eliaquim Mangala to their list of transfer targets for the summer.
The 22-year-old has been watched by Manchester United, Bayern Munich and AC Milan in recent months after a series of impressive performances while Arsenal have also followed his progress.
Porto want £17.5million for the France U21 centre half and will sell this summer.
Target man: Eliaquim Mangala (right) is being monitored by Manchester City
City have also watched Roma's Brazilian centre back Marquinhos, St Etienne's Kurt Zouma and Marseille's Nicolas Nkoulou but Mangala particularly impressed them during last week's Champions League tie with Malaga.
City want five new players in the summer as they look to overhaul their squad with Edin Dzeko and Samir Nasri among those likely to leave.
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domain: news


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Tag: Environmental health officers
The Malta Environmental Health Officers Association is insisting that the government take immediate action to ban mass events, close clubs and bars and introduce mandatory testing on incoming travellers as soon as possible in the wake of the ongoing spike in Covid-19 cases.
The police and the environmental health officers carried out a total 432 inspections between Wednesday and Thursday.
Out of 315 inspections, no one was found breaching mandatory quarantine regulations, the government announced. in the daily coronavirus bulletin.
124 fines issued today


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In an open letter to “Baylor Nation,” the fired football coach decries the “onslaught of information coming out in the press that is inaccurate, misleading and unfair."
Darnay Holmes's little nephew had a clear favorite.
The powder, which was thrown from the crowd, tested negative for dangerous substances.
The Crimson Tide captains didn't refuse anything. They shook hands with Washington before the coin toss.
Stanford running back Christian McCaffrey's decision to sit out his team's bowl game looks even smarter.
Maybe he'll have better luck with FAU's drivers next year.
Pumphrey finishes his collegiate career with 6,405 rushing yards, which would be second all-time if bowl game stats were counted when former Wisconsin star Ron Dayne was playing.
The two schools were each docked $25,000 -- the maximum amount allowable per conference bylaws -- for accepting leaked game-plan information from a former Wake Forest football assistant and broadcaster.
In announcing the suspension of Lonnie Galloway, athletic director Tom Jurich expressed regret on Friday "that this took place."
Mixon was suspended for the 2014 season after punching a female student in a restaurant near the school's campus.

domain: sports


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A Child dream… The lines of the Ferrari Testarossa
I’ve been enjoying these clips for a while now and find it strange why I never put these on my site… So for now on I’ll be posting…


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After a scathing report about inflated staffing numbers in nursing homes surfaced last week, Washington’s Gov. Jay Inslee signed a law this week that ensures residents receive 3.2 hours of direct care daily.
The “safe staffing” bill was proposed after several concerns arose about there being too many facilities and not enough caregivers to meet the needs of residents.
Shelly Hughes, a certified nursing assistant who has worked in Washington nursing homes for five years, testified for the bill and told Public News Service, “I feel like the ‘age wave,’ the fact that there are so many people retiring in our state is present in folks’ minds. People are starting to talk about it. I believe it’s about total care; it’s about this continuum of care, so that people can age with dignity in our state.”
The Washington law goes into effect in July 1, 2016. A committee made up of industry leaders, caregivers, residents and family members will be formed to determine how to meet staffing levels to meet the 3.2-hour per day requirement.
California and Oregon have similar direct-care laws on the books too. California’s law, enacted in 2003, also requires 3.2 nursing hours per resident per day. Oregon’s law, enacted in 2013, operates at 2.46 nursing hours per resident per day.
Inflating staff numbers on Medicare.gov’s Nursing Home Compare tool isn’t a new problem. In a recent report from the Center for Public Integrity, it was found that more than 80 percent of nursing homes were consistently lying about their staff numbers to get a higher ranking. In some cases, nursing homes reported they had twice the staffing hours they actually had, which gives families looking for nursing homes inaccurate information.
The Centers for Medicare & Medicaid Services changed its five-star rating system in February to reconfigure the way staffing changes are determined, but it remains an issue.

domain: sociology


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COVID-19: How RBC Wealth Management is helping clients. Learn more
It has never been more important for families to find ways to effectively build and maintain their wealth—and the services of a family office can help.
The second quarter of 2021 saw a seismic shift in the way large oil producers will operate going forward.
Does ESG lead to outperformance?
When it comes to investing, many people seek only returns without thinking about what their money is supporting.
Learn why HGTV Canada’s Bryan and Sarah Baeumler use the new RBC Wealth Management experience on the RBC Mobile app to access their accounts – wherever and whenever they need.
The spread of the Delta variant of COVID-19 and slow vaccination rates in many emerging market economies created another detour in the road to recovery for the global economy.
The expiration of federal benefits is likely to kick start millions of job seekers, and we see positive and negative implications for the economy.
Over the next decade, 750,000 Indigenous youth will move through the education system and into early careers. What will they need to thrive?
As the increasing federal debt dilemma continues, the U.S. government and taxpayers may reach a financial destination they have not been before.
As the delta variant spreads and U.S. inflation persists, how long can the growth cycle last?


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BlackBox Controls Ltd present MERAID, an exciting range of very low cost fluid level sensors to help with controlling and managing fluid levels
The MERAID fluid sensors range allows you to have a direct readout of fluid levels or also available are a range of interfaces to several types of operating systems. These include Android, IOS and also for Windows or Linux there is a USB interface.
MERAID fluid sensors can also be integrated into your own bespoke control system to ptovide a very low cost solution.
This video shows the pipe level sensor working with an early version of the direct readout gauge.


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Ukrainian Foreign Minister Dmytro Kuleba toured the African continent last week and earlier this week, visiting Senegal, Ivory Coast, Ghana and Kenya, among others.
Africa and Ukraine “they are in the same fate,” the head of Ukrainian diplomacy said today, saying that “every Russian missile not only hits Ukrainians, but also affects the quality of life of Africans.”
The Minister of Foreign Affairs of Ukraine Dmytro Kuleba toured the African continent last week and earlier this week, visiting Senegal, Ivory Coast, Ghana and Kenya, among others.
He cut short his tour of Africa on Monday after massive Russian bombings in Ukraine.
“We are boiling in the same cauldron,” the Ukrainian foreign minister said during an online press conference organized with African media, referring in particular to the war’s impact on “global food security.”
He added that “830,000 tons of grain have been delivered to African countries” since July.
Ukraine and Russia are among the world’s biggest exporters of grain, whose prices have soared since the start of the war. The opening of an export corridor on the Black Sea helped to stem this increase.
Kuleba also welcomed Wednesday’s vote by the UN General Assembly on a resolution condemning the “illegal annexations” of Ukrainian territory.
The United Nations General Assembly condemned the recent “illegal annexations” of four Ukrainian regions to the Russian Federation, approving the draft resolution tabled by 143 votes to 5 with 35 abstentions.
“I was particularly pleased to see that the four countries I visited in Africa (…) supported this resolution,” Kuleba said.
Eritrea, which in March rejected the resolution condemning the Russian invasion of Ukraine, this time abstained. “It’s a step in the right direction,” Kuleba said.
The Ukrainian foreign minister also underlined the abstention of the Central African Republic, “a country militarily dependent on Russia”, where mercenaries of the Russian private military company Wagner have been deployed there for several years now.
“Russia’s biggest investment in Africa is sending Wagner mercenaries,” he said.
Asked about recent comments by Kenyan President William Ruto, who said he was open to buying Russian oil, the Ukrainian foreign minister stressed that “Kenya voted for the resolution,” before continuing that the country “has the sovereign right to do what it wants.” ,what does she want”.
Kuleba added that Ukraine is “ready to receive President Macky Sall”, the head of state of Senegal and current chairman of the African Union, but no date has been set for such a visit.
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domain: geography


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As the Orlando resort celebrates a half century of Magic, we look back to its growth and highlight new attractions, experiences and treats.
In the words of an official Walt Disney World press release this is “a world of fun and fantasy, where teacups spin, elephants fly and life’s cares melt away at the gates”. This not only perfectly encapsulates the vision, but explains why countless millions of visitors flock to Florida to enjoy this unique experience.
Walt Disney World Resort’s 50th Anniversary began on October 1, 2021, but ‘The World’s Most Magical Celebration’ continues on into 2023 with many new attractions and special experiences.
Listed below are some of these highlights. But first let’s look at the remarkable story of how it all began and has continued to grow.
“WALT DISNEY WORLD is a tribute to the philosophy and life of Walter Elias Disney and to the talents, the dedication and the loyalty of the entire Disney organization that made Walt Disney’s dream come true. May Walt Disney World bring Joy and Inspiration and New Knowledge to all who come to this happy place…a Magic Kingdom where the young at heart of all ages can laugh and play and learn — together.”
These are the words on a plaque dedicated on October 25, 1971, by Roy O. Disney, Walt’s older brother.
Very sadly, Walt did not live to see that day, but after years of planning and construction, his much-anticipated “Florida Project” was open and ready to welcome the world. The cost of the project was $400 million. Nearly 28,000 acres had been purchased from more than 100 property owners at a total cost of nearly $5.5 million.
From one theme park, two resort hotels and two golf courses, Walt’s dream expanded to four theme parks, two water parks, more than two dozen resort hotels, Disney Vacation Club properties, Disney’s Fort Wilderness Resort & Campground, 63 holes of championship golf, ESPN Wide World of Sports Complex, Disney’s BoardWalk entertainment enclave and Disney Springs, a waterfront entertainment, dining and shopping district.
The vision was constantly expanding from ‘complete destination-vacation resort’ to the concept of EPCOT – Experimental Prototype Community of Tomorrow. Walt believed he could apply the unique Disney approach to planning for all areas of family life.
By 1982 attendance had passed 100 million visitors.
Disney growth, however, really took off in the 1990s. The Disney Decade was a vision put forward by Disney Chairman Michael D. Eisner.
The Disney Decade saw the creation of Disney’s Animal Kingdom in 1998 with 13 animal-themed adventures. It was also in the 1990s that Disney Vacation Club gave fans the chance to own a piece of magic. In the new Downtown Disney DisneyQuest and Cirque du Soleil® came to town.
The City of Celebration was built – with the vision as a ‘perfect’ place to live. Now no longer owned by Disney it’s a gorgeous place to visit with its streets of New England-style homes and individual shops and restaurants.
Disney Cruise Line, with two ships, the Disney Magic and the Disney Wonder, sailing from Port Canaveral, Florida added to the immense offering from the company.
Some significant dates…
October 1 – Walt Disney World officially opens to the public. Phase one includes Magic Kingdom Park, Disney’s Contemporary Resort and Disney’s Polynesian Village Resort. There are monorails, watercraft, trams and motor coaches to transport guests from park to park and back to hotels.
EPCOT opens with five Future World pavilions – Spaceship Earth, Universe of Energy, World of Motion, Journey Into Imagination and The Land – and nine World Showcase pavilions representing Mexico, China, Germany, Italy, The American Adventure, Japan, France, United Kingdom and Canada.
Disney’s Grand Floridian Resort & Spa opens as the flagship of Walt Disney World Resort hotels. It’s followed on October 1 by Disney’s Caribbean Beach Resort.
Disney’s Hollywood Studios opens with Tinseltown glamour, major entertainment attractions and behind-the-scenes looks at movie-making.
The nighttime entertainment complex Pleasure Island opens with a glittering array of restaurants and themed nightclubs. In 2008 it makes way for the updated Disney Springs.
Disney’s Typhoon Lagoon water park opens, featuring a 95-foot-high mountain, eight water slides and a 2.5-acre wave pool.
The first phase of the EPCOT Resort Area opens with the debut of Disney’s Yacht Club Resort and Disney’s Beach Club Resort. The following year brings Walt Disney World Swan Hotel and the Walt Disney World Dolphin Hotel.
The Walt Disney Company dedicates 8,500 acres of land purchased at the Osceola-Polk County line to The Nature Conservancy to preserve for future generations as the Disney Wilderness Preserve.
Disney’s Hollywood Studios expands with a new themed area, Sunset Boulevard and thrill ride The Twilight Zone Tower of Terror.
Walt Disney World Resort continues to expand accommodation with the openings of: Disney’s Wilderness Lodge, Disney’s All-Star Sports Resort and Disney’s All-Star Music Resort.
Disney’s Blizzard Beach water park debuts.
Walt Disney World Resort celebrates its 25th anniversary with a year-long celebration.
Disney’s Coronado Springs Resort opens.
Disney’s Animal Kingdom Theme Park opens on Earth Day. At 500 acres, it is Disney’s largest park and home to approximately 1,800 animals representing 200 species.
Disney’s Animal Kingdom Lodge opens.
100 Years of Magic Celebration commences, honoring the 100th anniversary of Walt Disney’s birth. A 122-foot-tall Sorcerer Mickey hat becomes an icon for Disney’s Hollywood Studios, where Walt Disney: One Man’s Dream also opens to take guests on a journey through the life of Walt Disney.
Walt Disney World joins in the “Happiest Celebration on Earth,” saluting the 50th anniversary of Disneyland Resort in California.
My Disney Experience mobile app launch to help guests plan and experience Walt Disney World Resort.
Disney Springs – an upgraded retail, dining and entertainment district opens.
Star Wars: Galaxy’s Edge opens at Disney’s Hollywood Studios – a 14-acre land to experience Star Wars stories.
Disney Skyliner takes flight. This grand, state-of-the-art gondola system connects EPCOT and Disney’s Hollywood Studios to four Disney Resort hotels.
“The World’s Most Magical Celebration” began.
Guardians of the Galaxy: Cosmic Rewind, is Epcot’s first “other-world” showcase pavilion – a family-friendly adventure featuring a new storytelling coaster that rotates 360 degrees to focus on the action, including the first reverse launch on a Disney coaster.
Remy’s Ratatouille Adventure at Epcot, is where guests shrink to the size of Chef Remy and race through Gusteau’s restaurant on a wild adventure.
HarmonioUS, at Epcot is the largest nighttime spectacular ever created for a Disney park, featuring massive floating set pieces, custom-built LED panels, choreographed moving fountains, lights, pyrotechnics, lasers and more.
‘Disney Enchantment’ at Magic Kingdom Park is a breathtaking spectacle featuring Disney music, stunning fireworks, enhanced lighting and immersive projection effects that extend for the first time from Cinderella Castle down Main Street, U.S.A.
Space 220 Restaurant – has virtual daytime and nighttime views of Earth from 220 miles above the planet’s surface. Guests board a space elevator for a simulated journey to the Centauri Space Station, where they experience the “height of dining.”
‘Disney KiteTails’ at Animal Kingdom Theme Park is a new daytime entertainment.
50th Anniversary Celebration Sips and Bites – more than 150 new food and drink offerings with a touch of EARidescent shimmer.
Call our Silver Travel Advisors to get further information, receive a quote and book a trip: call 0800 412 5678.


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New work by San Francisco-based artist Seamus Conley (previously featured here). See more images from “STEALTH ONES” below.
Seamus Conley’s Website
Seamus Conley on Instagram
19.07.19 — Staff
If you’re not a member of our Secret Email Club you’ve been missing out on a whole lot of stuff that we don’t post on Booooooom!


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Fat loss can be a challenging journey. One needs to not just focus on workout routine, but also on diet as fat loss depends on varied factors. Hormones largely influence weight, which in turn, can be controlled by a special focus on eating habits.
According to nutritionist Rashi Chowdhary, you need to reset three hormones — prolactin, insulin and thyroid antibodies — for optimal fat loss. She took to Instagram to share how to reset these hormones by cutting down certain food items from your diet. Take a look.
View this post on Instagram
Here’s what the nutritionist suggested about resetting your hormones.
*Reset your prolactin by cutting out on dairy. Optimal ranges should be between 4-20 ng/ml
*Reset your insulin by cutting your sugar and refined carb intake. Pick slow carbs. Don’t go low carb. Optimal ranges should be less than 7 uIU/mL fasting and should never rise above 30 uIU/mL after one and two-hour checks.
*Reset your thyroid antibodies by cutting out gluten. Optimal ranges should be <2 IU/mL for thyroid peroxidase antibodies (TPO) and <2 IU/mL for thyroglobulin antibodies (TG).
She, further, explained how these foods impact your hormones.
*Excess prolactin blocks the secretion of follicle-stimulating hormone (FSH). This can slow down or inhibit the production of eggs. Having dairy products could lead to excess prolactin in the blood (hyperprolactinemia). Another reason could be the development of a lump in the pituitary gland called prolactinoma.
*Refined carbs and sugar-laden foods are easily and immediately utilised for energy by the body because of their simple chemical structure, which leads to a faster rise in blood sugar and insulin secretion from the pancreas – which can mess up your insulin response over time and leaves you hungry almost immediately even after having a big meal.
*Certain foods disrupt the normal functioning of the thyroid, such as gluten. Gluten causes inflammation that slows down thyroid function and triggers an autoimmune response in the body that attacks the thyroid. And that’s because the molecular structure of gluten resembles that of the thyroid. Exclude gluten from your meals. Wheat, barley, rye, and spelt have gluten. Make sure you avoid all the wheat products too, like semolina, vermicelli, broken wheat, wheat pasta, bread, cakes to reset your thyroid.
“You don’t need to give it up completely but you need to minimise as much as possible,” the nutritionist concluded.
As Annie Ernaux wins Nobel Prize 2022 in Literature, a look at the past winners


Approx. Rs 1 / PieceGet Latest Price
|Material||Alloy Electrical Contact|
The special alloy electric contact is a new kind of Electric Contact, which is very cheap and has a high property. The new materials can be widely applied into many kinds of electric circuit breaker, contact and other low volt electric apparatus. After continuing research and accumulating experience, the products’ quality could now meet the requirement of practical use of many electric apparatus.
To further meet customer requirements, we have developed a new kind of special alloy electric contact, which has a three-layer structure, thus the applied areas of special alloy electric contact could are expanded. The three-layer structure involves a surface layer of Ag alloy, a matrix layer of special alloy electric contact and an under-matrix layer of solder as welding materials. The compositions and producting methods of the three layers have independent intellectual rights. With the application of a special technique, the Ag alloy layer and special alloy layer is perfectly connected, thus the product cost is largely decreased, and also the antioxidant capacity of Ag as well as the long life span and high anti-welding properties are reserved. In the quality tests, the results prove that the new materials improve the quality and stability of many electric apparatus, and therefore have a promising future in many applications.
The three-layer structure could achieve different properties meeting the demands from customers through different compositions and thickness of Ag alloy. The composition can include all traditional ones and the thickness varying from several um to mm. Now with a mature production technology, advanced testing equipments and perfect production management, the company is now open for large amount of order and can deliver as scheduled.


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IndyCar has refreshed its over-the-top (OTT) platform IndyCar Live! for the 2023 season.
- Access to be fully localised in each market
- OTT platform brings IndyCar coverage to dark markets
- In-car cameras now available as supplement to live broadcast
- Added comprehensive video on demand (VOD) archive
Context: IndyCar launched its OTT platform at the start of the 2022 season, which is available globally (excluding Russia and the US), in collaboration with Swedish sports streaming company Staylive.
Comment: Michael Montri, vice president of promoter and broadcast partnerships at IndyCar, said: “After a successful first season of OTT delivery in 2022, we have worked closely with Staylive to dive deep into data and shape our streaming and content strategy for 2023 and beyond. Staylive have taken a data driven approach in supporting our development across both technology and DTC strategy and we are delighted with the results seen over the weekend as we hit new audiences in markets previously invisible to us.”
Consequence: The move to refresh the platform and curate content on a country-by-country basis has seen “transactions and engagements from previously unreached markets”, according to Matt Parker, chief commercial officer at Staylive.


Wed, 26 Sep 07
Research from Propertyfinder.com reveals that 61% of people believe more affordable housing is needed for key workers - as long as it’s not built near them...
The latest Propertyfinder.com survey looked at public attitudes towards the planning process and new residential developments and found that, in principle, most people backed the idea of new housing to address supply problems.
When it came to their own area however, only 39.1% wanted more housing built. The findings come as it was announced last week that buying a home is out of reach for key public sector workers in more than two thirds of
People were also hostile to new high density developments. They had a strong preference for building houses rather than flats. Only 8.6% of people supported converting a nearby house into flats, while a mere 11.3% favoured a new block of flats. Over three-quarters of people (77.6%) were open to a planning application for a single new dwelling close by however.
Warren Bright, Chief Executive officer of Propertyfinder.com commented:
It seems the Not-In-My-Back-Yard mentality is alive and well in the
Planning and environmental concerns
The planning process itself also received a lot of criticism. An overwhelming number of people who had been involved in a planning application found it overcomplicated, hard to understand, and involving too much red tape. 67.9% of people said the process takes too long, and only half felt that enough consideration was given to local objections.
Environmental concerns were a significant factor for many people. 75.3% were against using local green space for residential projects. There was also a clear preference for any new developments to be inconspicuous and in keeping with other properties in the area. Only one in ten people wanted different and eye-catching new residential developments, and mock period-style architecture was most favoured.
Respondents also offered their views on the impact of new residents, which goes some way to explaining people’s resistance to new developments. Traffic was a key objection. Almost three-quarters of people feared an influx of new cars would mean a lack of parking, as well as more congestion. The extra noise caused by potential new residents was a concern for 53.9% of people, but they were also worried about the ability of local services to cope with an increase in population.
Table 1: NIMBY Moans and Groans
Key objections to new local developments
1. Threat to local green space
2. Congestion/lack of parking
4. Pressure on local services such as schools and GPs
Table 2: Preferences for development in local area
Public opinion towards types of development locally
(most popular to least)
1. Converting a house back from flats to a single dwelling
2. Converting local landmarks such as warehouses for residential purposes to preserve the building
3. New single dwellings to replace existing ones
4. Replacing property nearby with a new block of flats
5. Converting a nearby house into multiple flats
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Following are Research Articles associated with keyword Necator
Mughees Anjum Hookworm infection. Professional Med J Oct - Dec 2007;14(4):547-50.
Mughees Anjum Hookworm infection its correlation with packed cell volume in a rural community of Pakistan. Professional Med J Jan - Mar 2007;14(1):33-5.
Mughees Anjum Hookworm infection; its correlation with haemoglobin in rural population of Mustafa Abad (Lulliani) District Kasur. Professional Med J Jan - Mar 2006;13(1):54-6.
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domain: health


Solar wireless LED strobe traffic signal warning light
Solar Warning Light
High Brightness LED
Red, Blue or Customized
Flashing, 160 Times/minute or customized
Flashing 12 hours or 24 hours per day
530mm * 170mm * 140mm
100000 Set/Sets per Month
Packaging & Delivery
Double sides 4 sets red and blue solar wiress LED strobe traffic signal warning light;
Standard export carton box package or customized.
1 - 1000
To be negotiated
Double sides 4 sets red and blue solar wireless LED strobe traffic signal warning light
LED solar traffic sign is an environmental protection traffic signage, Adopt unique aluminum alloy board and solar board combined together, with the features that LED light luminous long distance, active luminous, combined with reflective film passive luminous, it make text and images with a reflective film also with LED warning light transmit to us, strengthen the warning effect in day and night. Especially in rainy and foggy weather, solar LED warning signage can give drivers and pedestrians potent warning to ensure traffic safety.
OEM & ODM
530mm * 170mm * 140mm
Red, blue or customized
Highways, urban roads, etc.
Solar strobe light
18V, 10W monocrystalline silicon, life> 10 years
Maintenance-free lead-acid battery 12V/14AH, life> 3 years
Super bright red and blue LED lights, visible from> 1000 m
Light control, Can control whole day blinking or evening blinking
160 times/min, can be customized upon request
Charging 8H under sunshine can work more than 72H
-30 --- + 65 ° C temperature, continuous rainy weather work> 200H (determined by the flash mode)
550 * 170 * 200(MM)
Solar strobe light is widely used in school entrance, housing estate or government nearby, door or sidewalk nearby, road intersections, corners, bridges, etc. which have security risks. To remind drivers or pedestrians, It can effectively avoid traffic accidents and unexpected accidents.
1)If you do not install the solar series product on time after you received the products, please charge them under the sun outdoor once per month to ensure the effectiveness of battery;
2) OEM&ODM available;
3) Lifespan 3~5 years, 1 year warranty
Shenzhen LuMing Traffic Equipment Co., Ltd. was founded in 2006. It is a professional supplier of solar traffic products and traffic safety facilities. And it is an export-oriented high-tech enterprise that combined R&D, production, sales, and after-sale service together.
Flagship brands "LM", "LLM", Products are widely used in lots of highways, highway bridge and urban roads in native and abroad, it is selected as high quality products to many customers, with a good public praise over years, certifications and test reports all in readiness.


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Cozy Living Room With Cream Accents Wall Colors Plus Mixed With Beautiful Wall Flower Painting Decoration And Comfortable Red Plus Brown Sofa Sets
File Type: image/jpeg
Furniture — This furniture, is one of the 10 designs published under the gallery: Two Simple Ways For Blasting Accent Wall Ideas. In the next page, we have the warm bedroom themed with orange accents wall decoration plus paired with charming twin table lamp shade and splendid iron bed using blue bedding pattern [ ... ]. While in the previous page, we have the fascinating white bedroom combine with pastel blue accents wall decoration filled with comfy bed plus decorative wall picture frame and unique three rattan pouffe [ ... ].
View other and more furniture designs below.
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Interior Furniture Designs
Super Quick Craft Ideas for DIY Home Interior Decor Plan is complemented with several amazing interior and furniture design focusing on the furniture designs, namely: Brilliant design of quick craft ideas made of button in star, Awesome style of quick craft ideas made of paper also fanel material, Fancy party design with delicious meal of cup cake also alluring, Captivating paper claps made of stainless steel material with, and many more. [ continue ... ]
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A colorful, cloudless sunset taken through the trees at Lake Murray State Park in southern Oklahoma.
Folder: Sunrise and Sunsets
Uploaded: Sep 23, 2016
Tags: nature, landscape, water, lake, sunset, trees, pink, purple, cloudless, Lake Murray, Oklahoma, colorful
Boat In The Reeds. Lake Landscape With Boats. Beautiful lake sunset with fisherman boats. Polish lake landscape. Beautif
Nature Landscape and Hills
Bright nature landscape photography with boat, human and river
Nature landscape from Romania, sunset and clouds
Lake of Soustons Landscape Photo at sunset - Azur, Landes, Aquitaine, France
Winter susnet #sunset #nature #landscape #winter #view 6
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Winter susnet #sunset #nature #landscape #winter #view 17
Moxie 4k vs Skyred (SEA Launch Cup)
A piece of Art in the Heart of Amsterdam
Awesome glow; love it!


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« Back to Blog
Theft Trends Have Retail Workers Living in Fear
Organized theft is on the rise at retail stores, putting workers at increased risk. Stores lost $112.1 billion to retail theft in 2022 and projections indicate shoplifting may cost retailers over $140 billion in 2025. With little control over security measures, store employees find themselves having to choose between personal safety and a paycheck.
One case in point is the manager of a New Jersey Gap clothing store that left the job she loved due to threats of violence, personal attacks, and theft. The store was the target of frequent thefts of large quantities of merchandise and the manager herself was physically and verbally assaulted during one of the robberies. Gap management reportedly denied her requests for additional cameras and other security measures.
Additionally, a Walmart contractor in Texas was awarded $4.3 million after he suffered a broken ankle and head injury from colliding with a shoplifter who was fleeing the store, and a Colorado woman is in the process of suing Circle K for an incident where she stopped a knife-wielding man from trying to steal cigarettes and was fired her for “mishandling the situation.”
Owners of private property have a responsibility to protect visitors, patrons and employees. If you have been hurt at work due to a violent crime, you may be able to receive compensation for those injuries outside of workers’ compensation. Please contact us to discuss what happened and see if an experienced Philadelphia negligent security attorney can help.

domain: law


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The worst forms of child labour (IPEC) Convention No. 182 concerns the worst forms of child labour.
This section provides more information on what these worst forms are. You can then explore this further through the Taking action and useful resources section. This section details with difficult issues, but issues that are widespread all over the world today and affecting young people of all ages. What Jobs did Children Perform - Child Labor in North Carolina Textile Mills. "The biggest portion of the spinners was kids back then.
We'd piece up sometimes after the doffing boys who doffed the frames and we'd get caught up. "Personal history of Mary Lee Boost. (Byerly, 1986) In the South, "One mill worker in every four was between the ages of ten and fifteen. Health Issues - The Child Labor Education Project. Working conditions that are safe and healthy for adults may not be safe and healthy for children because of their physical differences.
Risks may be greater for children at various stages of development and may have long-term effects. Factors that may increase the health, safety, and developmental risk factors for children include: Match Factory Worker India, 1993 Photo: David Parker. Child Labor Facts and Statistics - The World Counts. TheWorldCounts, 24 April, 2014 From the Sweat of our Children It’s heartbreaking to think that in this age of technology and communications, where we know everything that’s happening in the farthest corner of the world, child labor is still allowed to exist.
This is one of the biggest roadblock to human rights worldwide. Child labor is defined by the International Labour Organisation as “work that deprives children of their childhood, their potential and their dignity, and that is harmful to physical and mental development.” Scholastic News In-depth: Child Labor. How to Help By Karen Fanning When Iqbal Masih was just 4 years old, his parents sold him into slavery to pay off a $12 debt.
For six years, the small boy spent his days crouched over a loom, weaving handmade carpets. Finally, when Iqbal was 10, he escaped. Speakers' Spotlight - Craig Kielburger. Speaker Activist | Co-Founder of Free the Children | Co-Founder and Co-CEO of Me to We Craig Kielburger is a social entrepreneur, New York Times bestselling author and captivating speaker, inspiring millions to improve their communities and the world through daily actions.
Craig is the co-founder, along with his brother, Marc, of Free The Children, an international charity, Me to We, an innovative social enterprise, and We Day, a signature youth empowerment event. Craig’s journey as a child rights activist began at the age of 12, when he reached for the morning comics and noticed the newspaper’s front page. The headline read, “Battled Child Labour, Boy, 12, Murdered.” Iqbal Masih and Craig Kielburger: children against child labour. Young people have the power to make a difference The single biggest problem we've had is adults who will not take us seriously, who think that because we are young we will oversimplify the issue of child labour and not do our research.
Many of our members are as young as nine or ten years old but we do our research as well as taking action. Child labour is a very complex problem, that's the truth. But that can't be used as an excuse not to take action. Does India's new 'Make in India' campaign mean 'Made by Children?' Their hands fly with the speed and precision of veteran assembly-line workers, pausing only to flick sweat from their shiny-smooth foreheads.
They construct box after cardboard box, designed for sari shops in far-off cities, stacking them into multi-hued towers that loom above their small, hunched bodies. Many of the workers are not yet teenagers, and they fill the dimly lighted corridors of the textile mills and warehouses of this industrial city in western India. Despite a law requiring every child younger than 14 to be in school full time, millions of Indian boys and girls still hold jobs, including more than 50,000 in Surat alone, according to estimates by human rights groups. India has declared that it wants to end child labor, but advocacy groups argue that a new government proposal could actually push more youngsters into the workforce, jeopardizing their education and putting them at greater risk of exploitation. In India, Missing School to Work in the Mine.


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Each of these stunning hand-rolled candles is made using the finest premier grade coloured beeswax foundation. With 100% braided cotton wicks, these candles are completely natural. These beeswax candles are pet friendly and pet safe due to its non-toxic and cleaner burning.
The natural candles have the most intriguing soft honey/earth scent.
Choose from 4 options:
1. 4 x Blue Beeswax candles with 4 x wooden candle stands
2. 4 x Red beeswax candles with 4 x wooden candle stands
3. 4 x Yellow beeswax candles with 4 x wooden candle stands
4. Multi-coloured: 2 x yellow, 1 x blue, 1 x red beeswax candle with 4 x wooden candle stands
Size: 80x40 mm each
Weight: 58g each
Set of 4 candles with 4 wooden stands
Average burning time: 3 hours
Our beeswax candles come directly from the hive and made at a family bee farm in Nitra region, Slovakia. They are hand-rolled by Marina and Erich Nevidansky.
Beeswax candles are slow-burning and produce a subtle aroma.
Beeswax is a natural, renewable substance, producing candles which, unlike their paraffin counterparts, do not emit black smoke.
They are considered an environmentally-friendly alternative to paraffin wax candles.
Pet safe and pet friendly due to its non-toxic cleaner-burning.
Beeswax candles are reported to improve allergy and asthma symptoms. Like air purifiers, beeswax candles release negative ions that neutralize the particles from air pollutants.
Luxury laser-cut wooden candle stands. Can be used as a hanging decoration, ornament for a Christmas tree od coaster for your hot or cold drink. These coasters are made from a natural material and may contain small marks or blemishes. This is part of the charm of wooden products.
Size: 90 x 3 mm
Directions for use:
Place on a stable, heat-proof surface, away from draughts and flammable objects before lighting. Beeswax candle can sometimes drip wax, so please ensure they are placed on the wooden stand.
Handmade in Slovakia. Essembled and packed in the UK.


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We are living above the natural capital of this planet, urban centres are burning water in major ways, the world's population is expected to rise by 2 billion by 2050. These were the issues addressed by the EU's Director-General for Environment, Karl Falkenberg.
So, the question is how do we deal with Africa's already famous water scarcity on top of these global issues?
Kenya's Minister of Water & Irrigation, Charity Kaluli Ngilu, emphasized the positive effects of public awareness of water that increased Kenya's budget to $500 million. A Minister of four years, Charity has witnessed first-hand the benefits of spreading the word and having the Kenyan government make water a priority. Knowing that about $324 million/year is lost due to poor sanitation with mainly informal areas being affected, the government has emphasized the need for decentralized water services.


BUT “NOT TO SPY”
by Sharon Rondeau
(May 18, 2018) — On Friday The New York Times not only conceded that an “informant” was used by the Federal Bureau of Investigation (FBI) to obtain information from at least two Trump campaign aides in 2016, but it also published additional information about the alleged informant.
The Times’s article, promoted by the publication as well as one of its writers, Maggie Haberman, is titled, “F.B.I. Used Informant to Investigate Ties to Campaign, Not to Spy, as Trump Claims.”
The Times’s contention is eerily is similar to a statement made Friday by Barack Hussein Obama’s Director of National Intelligence, James Clapper, who told CNN that “They [the Obama admin’s FBI] may have had someone who was talking to them in the campaign, but, you know, the focus here… is not on the campaign, per se, but what the Russians were doing.”
As this publication reported during the 9:00 p.m. EDT hour on Friday, FNC commentator Sean Hannity opined that The Times and The Washington Post have revealed more about the “top-secret intelligence source,” leaked by individuals in the intelligence community, than anyone else, even those suspecting the identity of the person early on such as Strassel.
On Friday Hannity said that he has known the person’s identity for “more than a week.”
The Times’s article, promoted on Twitter, identifies “the informant” as “an American academic who teaches in Britain.”
In March, prior to the revelation of an FBI “informant” or “mole” from within or outside of the Trump campaign, The Daily Caller reported, in part:
Two months before the 2016 election, George Papadopoulos received a strange request for a meeting in London, one of several the young Trump adviser would be offered — and he would accept — during the presidential campaign.
The meeting request, which has not been reported until now, came from Stefan Halper, a foreign policy expert and Cambridge professor with connections to the CIA and its British counterpart, MI6.
Halper’s September 2016 outreach to Papadopoulos wasn’t his only contact with Trump campaign members. The 73-year-old professor, a veteran of three Republican administrations, met with two other campaign advisers, The Daily Caller News Foundation learned.
In response to The Times’s article in its Twitter timeline, The Post & Email tweeted, “And Barack Obama’s ‘long-form’ birth certificate is authentic.”
Since early 2012, when a former detective working under the authority of the Maricopa County Sheriff’s Office (MCSO) revealed that his then-six-month probe into the image posted at whitehouse.gov said to be a scan of a certified copy of Obama’s original birth certificate from Hawaii is a forgery, The Times, The Post and all other mainstream media outlets have marginalized the issue, ridiculed the messengers, and toed the line that Obama was “born in Hawaii.”
In its Friday article, The Times stated that Trump “accused the F.B.I. on Friday, without any evidence, of sending a spy to secretly infiltrate his 2016 campaign ‘for political purposes’…”
Neither The Times nor any other outlet has ever possessed “any evidence” that Obama was “born in Hawaii,” as no hospital will confirm the claim and no “documentation” released by the Obama campaign or White House has been proven to be authentic.
In fact, his “short-form” and “long-form” birth certificates, as well as his purported Selective Service registration form, have all been deemed forgeries by a five-year criminal investigation, something the U.S. media has worked assiduously to obscure.
In December 2016, then-Maricopa County Sheriff and current U.S. Senate candidate Joseph M. Arpaio and investigator Mike Zullo said that all of the evidence they accumulated over the 5+ years of the probe, some of which had not been made public through three press conferences, would be turned over to “federal authorities.”
Contrary to an April 27, 2011 White House blog post by then-Communications Director Dan Pfeiffer stating that Obama’s personal attorney, Judith Corley, had arranged by letter to fly to the Hawaii Department of Health to obtain two certified copies of Obama’s original birth certificate, The Times reported on July 2, 2016 that an unidentified individual traveled to Hawaii in an attempt to “find” Obama’s birth certificate.
At the same time, the “paper of record” ridiculed Trump for having been a “nonstop ‘birther,'” meaning that he questioned the public narrative that Obama was born in Hawaii.
Obama’s birthplace is at the heart of whether or not he was constitutionally eligible to serve as president and commander-in-chief. Article II, Section 1, clause 5 of the U.S. Constitution requires that the chief executive be a “natural born Citizen.”
In addition to lingering questions which Obama’s claimed birth hospital refuses to answer, Obama claims a father who never became a U.S. citizen, which some legal scholars believe was sufficient reason to disqualify him regardless of his birthplace.
On his 2008 campaign website, Obama admitted to having been born with dual citizenship of Kenya and the United States given that his claimed father became a Kenyan citizen once that nation obtained its independence from the Crown in December 1963.
An approved 2010 revision to the Kenyan constitution, promoted by the Obama regime with U.S. taxpayer dollars, allows for anyone whose parent or parents were or are Kenyan citizens to claim the same for himself.
Additional unanswered questions are whether or not Clapper, former CIA Director James Brennan, and former FBI Directors James B. Comey and Robert S. Mueller, III have any knowledge as to the creator(s) of the Obama “document” forgeries.


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Small historic towns
We offer you your welcome
You will still find here what many of us have already lost: more time for a chat, more sensitivity for the little things in life and more pleasure in enjoying some of the joys that life gives to us.
15 Small Historic Towns hidden all over Austria like special gems allow you to participate in history and ambiance, pleasures of the table and very special hospitality, far from all hectic rush and the noise of the city.
Die mittelalterliche Braustadt
FREISTADT, die mittelalterliche Braustadt, die charmante Einkaufsstadt, die lebendige Messestadt, die abwechslungsreiche Sportstadt, die gemütliche Genussstadt.
Freistadt ist Geschichte entdecken.
Freistadt ist Gemeinschaft erleben.
Freistadt ist Kulinarisches genießen.
Freistadt ist Feste feiern. Seien Sie dabei!
1000 Years of Romanticism
Around 980 the Ottakar margraves in Styria built today’s Lamberg Castle. The settlement around the castle and the parish church are first mentioned in official documents in 985. In 1186, the town fell into the ownership of the Babenbergers.
The historical city
The town itself was first mentioned in a document in 1198, salt mining on the Dürrnberg Mountain already in 1191. The town charter was awarded between 1218 and 1232. Hallein has become known above all for its salt production and the archaeological finds dating back to the Celtic period.
The old saline buildings and salt mine recall the times in which salt was not only essential for life but meant above all money and power.
Baden bei Wien
Town of Roses and Horticulture
A certain Gottlieb Biedermeier – in his capacity of invented literary figure – lent his name to an entire epoch and is considered the epitome of this era, its people and lifestyle.
Baden bei Wien is Biedermeier through and through and a nostalgic place. Zest for life, entertainment and fun are the dominating forces; the town hosts the biggest casino of central europe, a modern roman spa and an operetta theatre renowned far beyond Austria’s borders.