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In order to exploit new genetic resources and provide fundamental materials for the breeding improvement of bread wheat quality, genetic variation of high-molecular-weight glutenin subunits and gliadin in 29 macha wheat accessions were observed by acidic polyacrylamide-gel electrophoresis and sodium dodecyl sulphate polyacrylamide-gel electrophoresis. Nine HMW-glutenin subunits alleles and 9 combinations were identified. Subunit null (82.8%), 7+8 (53.3%) and 2+12 (82.8%) scored the highest frequency at Glu-A1, Glu-B1 and Glu-D1 loci, respectively. In addition, subunits 7+9 (23.3%) was also found at higher frequency. A total of 49 gliadin bands and 28 patterns were detected and the polymorph among all accessions was identified in most of bands (97.96%). Furthermore, all materials could be clustered into three major groups based on genetic similarity coefficient. The results indicated that the variations of gliadin among macha accessions were not associated with their geographic origins.
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In the endosperm of wheat (Triticum aestivum L.), the main storage protein classes are glutenin and gliadin. The wheat baking quality is controlled by the content and composition of wheat endosperm proteins. Specific HMW-glutenin subunits have been closely associated with bread making quality (Payne, 1987; He et al., 1999; Barro et al., 2003; Edwards et al., 2007; Lefebvre and Mahmoudi, 2007). Glutenin and gliadin are generally considered to contribute to the viscosity and extensibility of gluten. Glutenins were composed of high-molecular-weight (HMW) subunits and low-molecular-weight (LMW) subunits. HMW-glutenin subunits are controlled by three gene loci, located on the long arm of chromosomes 1A, 1B and 1D and identified as Glu-A1, Glu-B1 and Glu-D1 (Payne, 1987). Gliadins on the other hand are encoded by the complex gene family, which located on the short arms of group 1 and 6 chromosomes (Lafiandra et al., 1984; Hassani et al., 2007).
In order to improve wheat quality breeding, it is essential to exploit the valuable gene resource from wheat relative species. One of the oldest hexaploid cultivated species, T. aestivum ssp. macha (2n = 6x = 42, AABBDD), that was grown mainly in the west of Gelugia in the past. It possessed stronger tillering ability, resist smut and moisture tolerance. Because it has the same genome structure as the common wheat, the useful genes of T. aestivum ssp. macha could be easy transferred into common wheat. Datiashvili (1983) found that there was better ratio between gliadin and glutenin in T. aestivum ssp. macha. Fang et al. (1997) suggested that moisture tolerance of macha wheat was controlled by a pair of dominant gene and further scored a SSR marker Xgwm148 (Fang and Cai, 2003). Zhang et al. (2003) further demonstrated that these genes are located on 5A chromosome based on RAPD marker. Xiong et al. (2006) also reported that macha wheat had higher plant height, strong tillering ability and more spikelets. However, little information for macha was investigated. This confined the utility of T. aestivum ssp. macha in wheat improvement breeding. In the present study, were report on genetic diversity of HMW-glutenin subunits and gliadin as evaluated in 29 T. aestivum ssp. macha accessions from 11 countries.
MATERIALS AND METHODS
Plant Materials: A total of 29 accessions from different countries were kindly provided by Dr. Harold Bockelaman, USDA-ARS, National Small Grains Collection (Table 1). This study was conducted in 2007. Electrophoresis was performed at the Triticeae Research Institute, Sichuan Agriculture University.
A-PAGE: According the standard protocol of ISTA acidic polyacrylamide-gel electrophoresis (pH 3.1) (A-PAGE) (Draper, 1987), the gliadin electrophoresis was carried out. Common wheat cultivar Chinese Spring was used as reference.
SDS-PAGE: According to the procedures of Ng and Bushuk (1987), the HMW-glutenin subunits were separated by sodium dodecyl sulphate polyacrylamide-gel electrophoresis (SDS-PAGE). HMW-glutenin subunits were identified according to Payne and Lawrence (1983). Common wheat cultivar Chinese Spring (null/7+8/2+12) and Chuanyu12 (1/7+8/5+10) were used as reference.
Statistic Analysis: The presence or absence of gliadin bands was carefully recorded. The present bands were recorded as 1 and the bands absent as 0. Based on the gliadin bands data, the Genetic Similarity (GS) was calculated according to Nei`s (1973) method as GS = 2Nij/(Ni+ Nj), where Ni is the number of the band in the material i; Nj is the number of the gliadin band in the material j; Nij is the number of the gliadin band shared by material i and j.
|Table 1:||A list of accessions and their country of origin|
Using the unweighted pair-group method, a clustering analysis was carried out based on GS index under NTSYS-pc (version 2.1) software.
Gliadin Variations: A total of 49 gliadin polymorphic bands and 28 patterns were detected in 29 T. aestivum ssp. macha accessions. The number of bands ranged from 19 to 34 per accession, with the mean of 25. Ten bands were detected in α-, β- and γ-region, respectively and 19 bands in ω-region. Twenty-two, nineteen, twenty-two and twenty-six gliadin patterns were identified in α-, β-, γ- and ω-region, respectively (Fig. 1). The genetic similarity (GS) among T. aestivum ssp. macha ranged from 0.29 to 0.95, with a mean of 0.61. Based on the gliadin GS coefficient, the genetic relationships among macha wheat accessions were further investigated by UPGMA program. The result indicated that all accessions could be divided into three groups at the 0.58 level of GS (Fig. 2). Group 1 contained 19 accessions, including all accessions from Hungary, Iran, Italy, United Kingdom and most of accessions from the Former Soviet Union and Georgia. It could be further divided into two subgroups at the 0.63 level of GS. Group 3 only contained one accessions (PI355513) from Former Soviet Union. Group 2 contained 9 accessions, including 5 accessions from Switzerland, United States, Denmark, Sweden and Russian Federation, respectively and 4 accessions from Georgia. Group 2 also could be further divided into two subgroups. One accession (PI572909) from Georgia formed subgroup 2, whereas other three accessions from Georgia were clustered in another subgroup. Therefore, the clustering of macha wheat is not associated with their geographic origin. These results also indicate that the macha wheat accessions from Former Soviet Union and Georgia had higher genetic variation than material from other sources.
|Fig. 1:||Gliadin patterns for 17 accessions of macha wheat in APAGE profile Note:The name of material was listed in Table 1, CS: Chinese spring, α, β, γ and ω refer to the corresponding gliadin region|
|Fig. 2:||A dendrogram generated from gliadin|
|Fig. 3:||HMW-GS of macha wheat accessions after SDS-PAGE Note:The name of material was listed in Table 1, CK1: Chinese spring, CK2: Chuanyu12|
HMW-GS Glutenin Variations: A total of 9 HMW-GS subunits were identified in all accessions, including 2, 5 and 2 subunits at Glu-A1, Glu-B1and Glu-D1 loci, respectively (Table 2) (Fig. 3). At the Glu-A1 locus, subunit null had the highest frequency (82.8%), whereas subunit 1 had low frequency (17.2%). At Glu-B1 locus, subunits 7+8 was the predominant frequency 55.2%, followed by subunit 7+9 (24.1%) and the subunits 8, 20 and 6+8 with low frequency were also detected. At Glu-D1 locus, only subunits 2+12 and 5+10 were identified and the former subunit had the highest frequency (82.8%). Nine HMW-GS patterns were identified among all accessions. The distribution of HMW-glutenin patterns are listed in Table 3.
|Table 2:||The distribution frequency of HMW-GS alleles in macha wheat accessions|
|Table 3:||The combination and distribution frequency of HMW-GS in macha wheat accessions|
The pattern null/7+8/2+12 was detected in 10 accessions and had the highest frequency. Four patterns, including null/7+9/2+12, null/7+8/5+10, 1/7+8/2+12 and 1/7+9/2+12, had higher frequency. The HMW-GS pattern 1/6+8/2+12 and null/20/2+12 were only observed at low frequency.
The gliadin patterns with a great diversity of variations have been used as fingerprints, genotype identification, quality markers and so on (Yan et al., 1992; Liu et al., 1999; Lang et al., 2001). Zhang et al. (1995) suggested that A-PAGE could provide an available method for identifying wheat germplasm. In this study, the higher genetic diversity of gliadin was found, a total of 28 gliadin patterns were identified in 29 T. aestivum ssp. macha. This indicates that gliadin could provide a valuable and exact diversity marker for T. aestivum ssp. macha accessions. These data is supported by the results of Khachidze (1989) who also observed a great diversity of variations in T. aestivum ssp. macha and found some bands in the patterns that is species specific. Yakobashvili and Naskidashvili (1988) reported that the greatest polymorphism (11 variants of gliadin blocks) was found for the gliadin locus on chromosome 6A. One of its variants was identical to block Gld 6A20 of bread wheat. Six variants of blocks associated with chromosome 1B, 3 were identical to blocks in bread wheat (Gld-1B4, Gld-1B8 and Gld-1B10). Metakovsky and Iakobashvili (1990) further reported an additional component mapped between Glu-B1 and Gli1B in the gliadin spectrum of T. aestivum ssp. macha. The analyses of seed storage protein components of the gliadin and glutenin in T. aestivum ssp. compactum, T. aestivum ssp. sphaerococcum, T. aestivum ssp. macha, T. aestivum ssp. spelta had revealed limited variation at the tightly linked coding loci Gli-D1/Glu-D3 and Glu-D1, located respectively on the short and long arm of chromosome 1D and at the Gli-D2 locus, positioned on the short arm of chromosome 6D (Lafiandra et al., 1992).
In this study, a great diversity of variations on gliadin loci in T. aestivum ssp. macha accessions, while the relationship between genetic variety and other properties traits need further study. Meanwhile, two accessions with the same gliadin bands had no diversity in all properties, but had further close relative relations, such as PI352466 and PI355508 used in this study. So the genetic varieties between accessions need other methods, like by molecular marker technology to detect and analyses.
In the tree of the cluster analysis, accessions from Georgia were clustered together, but only few accessions were grouped with other counties accessions. From the clustering dendrogram, the Georgia accessions could be divided into two groups. Accessions PI572908, PI572913, PI572906 and PI572909 formed a group, while others were another group. This indicates that there were two allelic variety types on gliadin locus in Georgia accessions. In this study, the clustering analysis indicated that the gliadin variations among T. aestivum ssp. macha are not associated with their geographic origin. High level of HMW-GS polymorphism was observed in the 29 T. aestivum ssp. macha by SDS-PAGE method. The main HMW-glutenin patterns was null (Glu-A1), In all ten Georgia accessions, the pattern (null, 7+8 and 2+12) had the highest frequency, the pattern (null, 7+9, 2+12) had the similar performance in Former Soviet Union accessions. The consistent efforts have been made to improve wheat quality by accumulating good HMW-glutenin subunits, such as 1, 5+10. Yakobashvili`s et al. (1988) indicated that the species included T. aestivum ssp. macha, T. aestivum ssp. spelta and T. aestivum ssp. aestivum were closely related through comparison with HMW glutenins of 3 species by SDS-PAGE. The greatest polymorphism in T. aestivum ssp. macha and T. aestivum ssp. spelta was for Glu-1B, for which the greatest difference between them was also found suggesting that they may had different donors of genome B.
This research was supported by the National Natural Science Foundation of China (No. 30300219 and 30571163) and A Foundation for the Author of National Excellent Doctoral Dissertation of PR China (No. 200357 and 200458). Y.-L. Zheng was supported by the Program for Changjiang Scholars and Innovative Research Teams in University of China (IRT0453).
- Barro, F., P. Barcelo, P.A. Lazzeri, P.R. Shewry, J. Ballesteros and N.A. Martin, 2003. Functional properties of flours from field grown transgenic wheat lines expressing the HMW glutenin subunit 1AX1 and 1DX5 genes. Mol. Breeding, 12: 223-229.
- Draper, S.R., 1987. ISTA and Variety committee: Report of the working group for biochemical tests for cultivar identification 1983-1986. Seed Sci. Tech., 15: 431-434.
- Edwards, N.M., M.C. Gianibelli T.N. McCaig, J.M. Clarke, N.P. Ames, O.R. Larroque and J.E. Dexter, 2007. Relationships between dough strength, polymeric protein quantity and composition for diverse durum wheat genotypes. J. Cereal Sci., 45: 140-149.
- Xianwen, F., C. Yang and C. Shibin, 1997. Genetic evaluation of waterlogging tolerance in Triticum macha. Jiangsu J. Agric. Sci., 13: 73-75.
- Hassani, M.E., M.R. Shariflou, M.C. Gianibelli and P.J. Sharp, 2008. Characterisation of a ω-gliadin gene in Triticum tauschii. J. Cereal Sci., 47: 59-67.
- He, G.Y., L. Rooke, S. Steele, F. Bekes and P. Gras et al., 1999. Transformation of pasta wheat (Triticum turgidum L. var. durum) with high-molecular-weight glutenin subunit genes and modification of dough functionality. Mol. Breeding, 5: 377-386.
- Lafiandra, D., D.D. Kasarda and R. Morris, 1984. Chromosomal assignment of genes coding for the wheat gliadin protein components of the cultivars Cheyenne and Chinese Spring by two dimensional (two-pH) electrophoresis. Theor. Applied Genet., 68: 531-539.
- Lafiandra, D., S. Masci, R. Dovidio, O.A. Tanzarella, E. Porceddu and B. Margiotta, 1992. Relationship between the D genome of hexaploid wheats (AABBDD) and Ae. Squarrosa as deduced by seed storage proteins and molecular marker analyses. Here. Landskrona, 116: 233-238.
- Lefebvre, J. and N. Mahmoudi, 2007. The pattern of the linear viscoelastic behaviour of wheat flour dough as delineated from the effects of water content and high molecular weight glutenin subunits composition. J. Cereal Sci., 45: 49-58.
- Hua, L., W. Yusheng and Z. Hui, 1999. Preliminary construction and application of gliadin fingerprints database of Chinese wheat germplasm. Acta Agron. Sin., 25: 674-682.
- Nei, M., 1973. Analysis of gene diversity in subdivided populations. Proc. Natl. Acad. Sci. USA., 70: 3321-3323.
- Ng, P.K.W. and W. Bushuk, 1987. Glutenin of Marquis wheat as a reference for estimating molecular weights of glutenin subunits by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Cereal Chem., 64: 324-327.
- Payne, P.I., 1987. Genetics of wheat storage proteins and the effect of allelic variation on breadmaking quality. Ann. Rev. Plant Physiol., 38: 141-153.
- Zhang, X., X. Yang and Y.S. Dong, 1995. Genetic analysis of wheat germplasm by acid polyacrylamide gel electrophoresis of gliadins. Sci. Agric. Sin. A, 28: 25-32.
- Zhang, J.L., S.B. Cai, G.X. Zhang, J.B. Wei, C.Q. Zhang and Z.Q. Ma, 2003. Genetic mapping of genes conferring waterlogging-tolerance in Triticum macha using RAPD markers. J. Nanjing Agric. Uni., 26: 7-10.


The latest phones from HTC, a company that has risen to stardom in the current generation of mobile phones, have been spotted out in the open with some brand new details.
First of all, the Desire HD will become the second mobile phone, and HTC’s first, to come pre-installed with Android 2.2. That’s according to a new product listing on online UK phone retailer mobiles.co.uk.
The Desire HD will pack in a 1 GHz Snapdraggon processor, an 8-megapixel camera, 720p HD video recording capabilities, and a massive 4.3-inch touchscreen. All of Android 2.2’s features will be included as well, of course, including Adobe Flash 10 and the ability to turn the phone into a mobile Wi-Fi hotspot for your laptop or any other device.
That same e-tailer also outed details of the HTC Desire Z, a less powerful addition to the company’s Desire line. It carries a 3.7-inch touchscreen with 480×800 resolution, with a 1 GHz Snapdraggon processor but will only come with Android 2.1. It will most likely get updated to 2.2 down the pike, however.
Pricing information and release dates are still waiting to be confirmed on both of these devices.
The “Desire” brand is kind of beginning to do for HTC what Droid did for Motorola, of course not to same magnitude though. The original HTC Desire (pictured above) has managed to sell through the channel quite well. Incidentally, HTC actually created one of the Droids on the market today – the Droid Incredible.
It also manufactured the very first Android phone, the G1, which was the catalyst for the previously unknown phone maker to leapfrog into a position as a leading smartphone manufacturer across the globe.


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ELEY RIMFIRE 22LR MATCH PISTOL 1070FPS 50 PK
Unfortunately we are unable to allow the purchase of this product online. This may be due to shipping or legal reasons. If you would like to purchase this product, please give the store a call or fill out the contact form below. Please note - Firearms can be purchased over the phone and shipped interstate, but must be collected in store or sent to your local dealer.
Match Pistol has been specifically designed for free pistol use, featuring many of the attributes of Tenex Pistol, this cartridge will be accessible to a large section of the shooting community for pistols and semi automatic rifles.
Bullet weight: 40 grains
Velocity: 1000 fps (10" barrel)
Lubricant: Beeswax / Tallow
Profile: Round Nose

domain: hobby


Pioneers of Tex-Mex / Norteño Music.
These tracks feature the incredibly emotive duets of the Segovia Sisters, who sang about love, betrayal, heartbreak, and all of the other great themes of rural music! These duets exemplify the hard-hitting sound of the women of the Texas/Mexican border region, with their big voices, blunt honesty, and haunting melodies.
1. La Pretenciosa (Ranchera) (The pretentious one)
2. Ando Pasando Trabajos (Ranchera) (I'm working it out)
3. Ya Me Voy (Bolero) (I'm leaving)
4. Tu Diras (Ranchera) (It's up to you)
5. Carinito Idolatrado (Cancion Fox) (I idolize your love)
6. Jesus Leal (Corrido) (The ballad of Jesus Leal)
7. Chatita Mia (Ranchera) (My little sweetheart)
8. Sin Derecho Y Sin Razon (Ranchera) (Without rights or reason)
9. Tu Condena (Ranchera) (Your sentence)
10. Hoy Te Digo Adios (Ranchera) (Today I say good-bye)
11. El Pajarillo Pelon (Ranchera) (The bald bird)
12. Que Te Echen La Tierra Encima (Ranchera) (Let them throw dirt on you)
“These dozen sides were issued by the Ideal and Falcon labels between 1950 and 1956… Most of these are swaying, plaintive rancheras with typical 1950s norteño backing, spotlighting the close and cheerful harmonies of the sisters (in varying combinations). A couple of tracks, however, really stick out for their incorporation of different pop influences. ‘Ya Me Voy,’ a bolero from 1953, has a most attractive rhumba-like beat, along with tooting horn and smooth, beguiling electric guitar, reflecting Cuban and Latin American pop music trends of the era.”


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A major exhibition of the work of Helmut Newton is to launch at Amsterdam’s Keizersgracht. The retrospective features in excess of 200 photographs from the Jewish-German fashion photographer, ranging from early prints that rarely go on display to his most iconic fashion photos.
Helmut Newton was born in Berlin in 1920 to a Jewish family, the son of Klara and Max Neustädter, a button factory owner. He purchased his first camera at the age of 12, and then worked for the German photographer Elsie Neulander Simon from 1936.
The increasingly oppressive restrictions placed on Jews by the Nuremberg laws meant that his father lost control of his factory.
Then, in November 1938, Newton’s father was briefly interned in a concentration camp on Kristallnacht, which finally compelled the family to leave Germany.
From those humble beginnings as a refugee, Newton rose to become one of the most celebrated fashion photographers of his generation – one credited with moving forward the depiction of women, and particular women’s sexuality, within the photography medium.
The majority of the works featured in the exhibition are vintage prints from the collection of the Helmut Newton Foundation in Berlin.
Women play a central role in Newton’s work. But this is also the reason why his work is often pigeon-holed as simply erotic, and why there’s insufficient appreciation of the intrinsic complexity and multi-layered nature of his oeuvre.
Newton started to photograph in the early 1950s, but his breakthrough didn’t come until the 1970s, with the photographs he produced on commission for French Vogue.
He quickly was talked of as a zeitgeist for an era of female emancipation. As a friend of Yves Saint Laurent and Karl Lagerfeld, he was at the forefront of a new wave of designers and photographers to try and change male-female dynamics in the fashion industry, while creating a new vision of femininity in the mainstream media.
Newton photographed primarily on location, using innovative scripts for his shoots. His women sometimes wore clothing more associated with menswear. They were dominant, totally in control; a far cry from the submissive figures that were such a part of European and American media and advertising throughout the preceding generation.
“He was all too aware that eroticism, seduction and desire primarily amount to a game of perception and of displaying an unattainable reality,” Foam said in a statement.
“Through the depiction of women and underlying themes such as power, violence, eroticism and desire, his work can be directly linked to themes in surrealism – one of the dominant artistic movements during the interbellum period when he was growing up in Berlin.
“Newton’s rich, authentic and complex oeuvre can be considered one of the most iconic of the last quarter of the 20th century.”
Helmut Newton – A Retrospective will run at Foam from 17 June to 4 September 2016.

domain: history


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- Native plants are plants that are indigenous to a region.
- They are well accustomed to the climate, soil and water availability.
- They are more resistant to disease and drought and contribute to soil health through nutrient release.
Happy Eco News will always remain free for anyone who needs it. Help us spread the good news about the environment!

domain: agronomy


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Japan 'Statue of Liberty' replica looking for new home
Saturday 21 August 2010
A replica of the Statue of Liberty is looking for a new home after being evicted from outside a shop in a historic Japanese port city following complaints from neighbours who branded it an eyesore.
The six-metre (20 foot) statue was lifted by a crane onto the rooftop of the two-storey fish shop on Thursday after a ceremony led by a Shinto priest, according to Japanese media.
"We will keep it there for the coming months when we are busy. But we will erect it again next year where it may not cause any trouble to anyone," Yoichi Kitamura, the statue's owner, told AFP by telephone Friday.
Kitamura, a wholesale crab dealer, had bought the steel statue from an Internet auction and installed it as a "landmark" in front of his new shop in Hakodate, in northern Japan.
The store is on a famous slope dotted with old buildings bearing testimony to the history of the city, one of three Japanese ports opened in 1859 to foreign trade after the country's isolation.
Neighbours were quick to demand the city order Kitamura to remove the statue.
City officials decided the statue broke conservation rules protecting the historic townscape of the area, which is home to an Orthodox church and other missionary buildings, and advised him to move it.
But Kitamura insisted it was installed for the right reasons.
The second floor of the shop is open for uses such as karaoke, Japanese chess and concerts for residents in the neighbourhood, which has an ageing population, he said.
"We installed a Statue of Liberty as a landmark after creating a place for free activities. But it is sad that the city is too narrow-minded to understand it," he said.
Television footage showed messages left on the statue by tourists such as "Don't tear it down" or "I pray it will remain there."
"Tourism is declining in Hakodate and I had thought the statue could be an ideal catalyst," he said. "It will be surely standing somewhere next year."
The original Statue of Liberty in New York, a French gift to commemorate the centenary of US independence, has spawned replicas and commercial copycat versions around the world.
In Japan, a bronze Statue of Liberty, authorised by the French government, stands on a landfill in the port of Tokyo. A fibre-reinforced plastic statue was built in 1990 in Aomori to mark the fact that the rural region is at the same latitude as New York.
- 1 To those who can’t see the point of International Women’s Day: you are the very reason it exists
- 2 International Women's Day 2014: The shocking statistics that show why it is still so important
- 4 Too upsetting? Academy members voted for Oscar-winning 12 Years A Slave 'without watching it'
Apple's Tim Cook: Business isn’t just about making profit
Thousands of young people forced to go without food after benefits wrongly stopped under 'draconian' new sanctions regime
Ukraine crisis: New navy chief 'defects' and surrenders Crimean HQ as Putin claims ultranationalists forced intervention
Britain's top vet sparks controversy with call for ban on slashing animals' throats in 'ritual' slaughters for halal and kosher meat products
Ukraine crisis: Russia dismisses '3am ultimatum' as 'total nonsense'
If you're horrified by a flame-roasted dog, you should be shocked at a hog roast
£12000 per annum: Inspiring Interns: A small but growing chain of boutique hot...
£12000 - £18000 per annum: Inspiring Interns: Our client is a high-end niche t...
£20000 - £40000 per annum + Award-Winning Benefits: Flight Centre Business Tra...
Unpaid: Kaya Responsible Travel: Increases in tourism, the introduction of new...

domain: news


text:
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS) which carries a significant burden of morbidity and mortality. Herein we examine the effects of acute treatment with tuftsin-phosphorylcholine (TPC), a novel immune-modulating helminth derived compound, on a murine model of MS. Experimental autoimmune encephalomyelitis (EAE) mice received acute treatment with TPC showed an improved clinical score and significantly less signs of inflammation and demyelination in CNS tissue compared with vehicle treated EAE mice. Our findings suggest that TPC may provide a beneficial clinical effect in EAE and may therefore have a potential value for ameliorating clinical manifestations and delaying disease progression in MS.
Keywords: Autoimmunity; Experimental autoimmune encephalomyelitis; Multiple sclerosis; Tuftsin-phosphorylcholine.
Copyright © 2019. Published by Elsevier B.V.

domain: literature


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The latest installment from the KesselsKramer Publishing arm is INK, an eclectic mix of short stories from international writers regarding their reason for choosing a tattoo. The stories are accompanied alongside fantastic illustrations by Swiss based HappyPets.
KesselsKramer Publishing has now amassed a 40+ strong back catalogue and we’re yet to see a dud.
- Vanguards magazine explores Scotland's undiscovered creative treasure
- Yoko Yuki takes us on a bizarre jaunt into town in this kaleidoscopic animation
- Director Nick Ahlmark captures the thrills of night riding for Vice and Samsung
- Marion Jdanoff's skillful screen prints and books are packed with vibrancy
- Illustrator Zoë Taylor’s heroine escapes a party through clichéd melodrama and sporadic linework
- Björk Vulnicura: inside the creation of the kafkaesque headpieces by James Merry and Neri Oxman
- Airbnb launches its own in-house design studio, Samara
- Subway unveils redesigned logo and new symbol
- Neubau introduces its latest immaculately minimal typeface, NB Akademie
- PES creates an epic scale, long-exposure stop motion film for Honda
- Rio Olympics 2016: the creative projects inspired by the Games
- Erin M Riley’s hand-woven tapestries re-contextualise online pornography (NSFW)


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A new federal government survey shows New York has a relatively low level of obesity among adults.
The rate in New York stood at 24.5 percent.
That compares with 12 states where at least 30 percent were obese.
Colorado was lowest, at just under 21 percent, and Mississippi was highest at nearly 35 percent.
The results were based on a telephone survey that asked adults their height and weight. For the first time, households with only cell phones were included.
More breaking news
- Ex-Assembly speaker convicted at NY corruption trial
- Marcum merger adds Nashville, Orlando offices
- Zillow: Higher rates, prices to slow 2016 housing market
- In Long Beach, Sandy still breeds hunger
- Tapping into the skill sets of 21st Century Workplace
- Noodles & Co. opens next week in Garden City Park
- Q&A with William Dudley
- Hammer time?
- NY-area construction starts up and down in October
- LIBN writer’s new play looks at innocence after guilty


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Girls’ Soundtrack Strikes a Chord
Staff writer Mark Lopez explores the aural world of buzz-worthy HBO comedy/drama “Girls.”
Music to Your Ears
As SXSW nears, scope which local bands are heading out to rep the 505 in Austin and South by sonic traffic slated for Burque.
The Best of Jethro Tull Performed by Ian Anderson at Kiva Auditorium
Battle of the Bands: Slow Jeremiah • Choking on Air • Brotherhood is Legend • Collapsing Skies • Alchemy for a Dead Man at Launchpad
Christine V at Ned's Bar & GrillMore Recommented Events ››

domain: entertainment


Tax assessments, from 1 July some acts may lapse: here are the ones.
If the tax authorities do not comply with the new obligation of prior contradictory, the investigations cannot be considered valid. What does it mean? In which cases could the taxpayer assert his right? The following are the changes that are about to come in the area of tax controls.
The news of the Revenue Agency
The Revenue Agency publishes the latest news regarding tax assessments. There circular no. 17 / E of 22 June 2020 clarifies in which cases the invitation to appear for the preliminary hearing before the assessment notice will be mandatory. Basically, the ways in which the taxpayer is missing is changing. Through the preventive contradictory, the latter is invited to justify his position before a real assessment. It is a form of protection for the taxpayer who can justify his position and exercise the right of defense.
From now on, the tax authorities must compulsorily invite the taxpayer to the cross-examination before starting a tax assessment. This is the introduction of a new iter on the controls regarding the financial administration. Through the obligation of preventive contradictory, the AdE, before issuing a notice of assessment, must activate the contradictory one with the taxpayer. Here’s what changes in the matter of tax assessments, from 1 July some acts may lapse: here are the ones.
What does all this mean? In the event that the tax authorities do not comply with the imposed obligation, the tax deed will be considered invalid. In essence, the taxpayer who does not receive the invitation to be heard could contest the assessment. This is provided that the interested party demonstrates the reasons that he could have put forward in the event of a cross-examination.
What investigations are involved in the measure
Tax assessments, from 1 July some acts may lapse: here are the ones. In relation to the new changes, the assessments for which the obligation of prior contradictory will apply from 1 July will be:
to) social security contributions;
b) withholding taxes;
c) substitute and regional taxes on production activities;
d) social security contributions;
is) taxes on property values and financial assets abroad;
f) value added taxes.
For these notices it will be mandatory that the taxpayer first receive the invitation to the preventive hearing. Exceptions are cases of particular urgency and well founded danger. These terms are intended to refer to those situations in which there are repeated violations or tight deadlines for fulfilments.
To find out how far back the tax assessments on taxpayers can go, you can consult the analysis here.


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As the world's leading steel supplier, we can provide a wide range of steel types, including carbon steel, weathering steel, boiler steel, structural steel, etc., and we can meet customers' requirements in any size, as well as the production of steel and complete plant plans. If you are interested in these aspects, please contact us.
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Gulf Cool Therm Factory Limited, as a manufacturers and suppliers of high quality:Polyisocyanurate, Polyurethane and Phenolic Foam Pipe, Duct, Wall, Roof, Tank and Vessel Insulations. Pre-insulated Pipes and Fittings for Industrial and District Cooling Applications.Phenolic Foam or PIR Pre-insulated Duct Insulation panel, Polyurethane Spray High Density Polyethylene (HDPE) and Low Density What is High Density Polyethylene and Low Density Polyethylene / HDPE and LDPE? Polyethylene, also referred to as PE, is a form of thermoplastic insulation. PE is found in various forms. It can be solid (common form) or foamed. One of the characteristics of Polyethylene is Insulation - NBS National BIM LibraryInsulation (151) Insulation can be used to internally or externally line a construction, be placed in a cavity of a construction or separate an element of the construction. Insulation can reduce the passage, transfer or leakage of heat, sound or fire.
Over the course of any major project, service engineers may have to install thousands of pipe clamps/clips on the pipework of a building. When installing these products, it is important to ensure there is a layer of insulation material between the metal clip and the pipework to prevent heat transfer and thermal bridging and in practice, most projects will either have phenolic insulated pipe Liquid Petroleum Asphalt-China Liquid Petroleum Asphalt China Liquid Petroleum Asphalt - Select 2020 Liquid Petroleum Asphalt products from verified China Liquid Petroleum Asphalt manufacturers, suppliers on Made-in-China. PDM US - "First In Pipes"Outer Jacket:Additional polyethylene jacket cover protects foam insulation from tearing during installation process. Foot Marking:Insulation incrementally marked by every foot to ensure accurate initial unit charge and reduce copper waste. R410:Can be used in applications where high-pressure gases are used as a refrigeration source.
Application fields of PU for pipe insulation Industry pipe Rigid and flexible pipes Fluid:liquid chemicals / steam Outer jacket:Polyethylene, metal sheet Carrier Pipe:Steel Temperature:-162 °C - +180 °C Rigid foam based on PUR or PIR Moulded density:60 - 120 kg/m³ If necessary fire resistence according to Pre-insulated pipes for industrial applicationsInside is the carrier pipe, which is typically made of steel, stainless steel, copper or plastic . Then comes an insulating layer of polyurethane foam (PUR foam), which is specially suited due to its high insulation qualities compared to mass and volume . On the outside is a protective jacket of plastic or steel . R-Values of Materials:Table of Insulation R-Values and Phenolic Foam Insulation R-Values:Phenolic foam spray insulation:4.8 - 7 21 :Phenolic foam insulation. Phenolic rigid panel. 8.3 4.4 - 8.2 20. 4 - 5 21 :Corrosion problems when in contact with steel roofing & moisture; very good air bypass leak sealing properties :Plaster, 1/2" lightweight:0.32 30
Eigerflex. Carrier pipe:Polyethylene (PE100) Insulation:CFC-free, 100% CO2-driven polyurethane foam (PUR) Jacket pipe:Sinusoidal corrugated, seamless extruded polyethylene (LLD-PE) Dimension:DN20 (3/4") - DN100 (4") Operating pressure:16 PN Operating temperature:30°C +20 °C Show more Skafte AS Your supplier of industrial pipe solutionsEigerflex. Carrier pipe:Polyethylene (PE100) Insulation:CFC-free, 100% CO2-driven polyurethane foam (PUR) Jacket pipe:Sinusoidal corrugated, seamless extruded polyethylene (LLD-PE) Dimension:DN20 (3/4") - DN100 (4") Operating pressure:16 PN Operating temperature:30°C +20 °C Show more Steel Pipe Insulation Products & Suppliers Engineering360description:1-roller type 750 lb load rating 8 inch pipe size power-green[r] cast iron roller material 8 pipe size - decimal 203.2 pipe size in mm power-strut[r] brand weight 319 lb per 100 pieces insulation thickness 1 1/2 to 4 inch bracket material steel pipe size -
Jan 24, 2019 · It is poured between the two metal supports during production. This foam, upon contact with the air, solidifies and glues the two plates together, creating a monolithic product with a very high insulating value. Rigid polyurethane (PUR) insulation products are highly effective, lightweight, and many can bond to most materials. Its extremely low The Difference Between PUR And Rockwool Insulated PanelsJan 24, 2019 · It is poured between the two metal supports during production. This foam, upon contact with the air, solidifies and glues the two plates together, creating a monolithic product with a very high insulating value. Rigid polyurethane (PUR) insulation products are highly effective, lightweight, and many can bond to most materials. Its extremely low Thermal Insulation Materials Dubai UAE & Insulation At Hapri Insulation the words Quality Products and Right Solutions epitomize the value we bring to our clients, and it's what differentiates us within the Insulation industry. Since our establishment in Dubai, UAE in 2003 , our company continues to be committed to manufacturing high quality of polyisocyanurite (PIR), polyurethane (PUR) and pre
offers 292 high density polyurethane foam pipe products. About 49% of these are other heat insulation materials, 9% are steel pipes, and 1% are plastic tubes. A wide variety of high density polyurethane foam pipe options are available to you, such as astm, api, and gb.

domain: chemistry


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The Man from Porlock : Engagements, 1944-1981
These essays by the poet and critic Theodore Weiss explore a problem already powerful in Lucretius, conspicuous with Shakespeare, and more than ever a concern for modern writers--the place; and price of poetry in a prose-minded world. Originally published in 1982. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.

domain: library


What is “Minor Building Work”?
Whatever you construct on your property needs plans, unless it is defined as “minor building work”. Even so the Act states very well in Part A: General Principles and Requirements (this was previously Part A: Administration), that any structural building work that is defined as “minor building work” requires approval by your local authority’s building control officer before you can commence with any work . So long as you make an application to get the proper approval from the local authority, you DO NOT NEED PLANS . But the law is also very clear in terms of compliance with the regulations; minor building work must adhere to the regulations.
Short-term structures also need permission from the local authority. This includes builders’ sheds, on-site toilets, and any other structure you may want to build (or be obliged to erect) for the building project.
The local authority will not give you approval to build a temporary building until you give certain information, so they are able to evaluate it. At very least they have to know:
• what the planned use and life span of the building will be
• the space in which it is to be built (in other words where you are intending to put it)
• the availability of proper materials from which it may be constructed
The Definition of “minor building work” in Terms of the Law
a ) the erection of poultry houses (hoender hokke or chicken coups) that are no more than ten square metres in size, aviaries that are no bigger than 20 square metres, solid fuel stores (for storing wood, coal, anthracite or similar) that are no more than ten square metres in area and no higher than two metres, tool sheds that are smaller than ten square metres, childrens’ playhouses that are no more than five square metres, cycle sheds no more than five square metres, greenhouses that are a maximum 15 square metres, open-sided car, caravan or boat shelters or carports that do not exceed 40 square metres in size, any freestanding wall built with masonry, concrete, steel, aluminum, or timber or any wire fence that does not exceed 1,8 m in height at any point above ground level and does not retain soil, any pergola, private swimming pool (although most local authorities do insist on plans), change room at a private swimming pool not exceeding 10 sq m in area .
b ) the replacement of a roof (or part of a roof) with the same or similar materials,
c ) the conversion of a door into a window, or a window into a door, without increasing the width of the opening,
d ) the making of an opening in a wall that doesn’t affect the structural safety of the building concerned,
e ) the partitioning or enlarging of any room by the erection or demolition of an internal wall, as long as it doesn’t affect the structural safety of the building,
f ) the section of any solar water heater not exceeding six square metres in area on any roof; or 12 square metres if the water heater is erected elsewhere,
g ) the erection of any building that the local council doesn’t believe plans are necessary for.
In the last example , it is up to the building control officer to make this assessment.
How This Affects You
We have had quite a few inquiries on this site relating to when and where plans are required. As you will see, there are some exceptions, but in the end it is up to the local authority to determine whether or not you need plans.
It also makes sense that the structures defined as minor building work will all need to be fit for purpose. So you can’t say you are putting together an aviary (which can be 20 square metres in area), and then build a brick building with windows, suitable for human habitation!


SAN JOSE – Dennis McElroy is on a mission.
A true believer in cold in-place recycling as an environmentally and economically superior method of street maintenance, Dennis is constantly advocating how CIR can help cash-strapped agencies tackle their growing backlogs of cracked up roads.
As Graniterock’s cold in-place recycling manager, he spends a great deal of time meeting agency officials to carefully explain the road rehabilitation technique and its benefits. He’s always looking for projects where dig outs and overlays can be swapped out for CIR.
His CIR sermons are striking a chord as more and more agencies throughout California - San Jose, Fremont, Hayward, Santa Clara County and Monterey County - are giving the technology a shot. And they’re discovering it’s the answer they’ve been looking for to smooth out bumpy roads without breaking the bank in the process.
“I’m not just selling CIR to sell it. I really believe in it,” Dennis said. “The savings in time and money are huge. Plus, it’s so much better for the environment to recycle our roads than to haul off all that material to the landfill.”
CIR is a road rehabilitation technique that recycles the top 3-6 inches of existing pavement to improve roadway surfaces without the need for grinding or new materials, which eliminates waste sent to landfills and all the truck trips that go along with it.
Much of Dennis’s attention lately has been centered on Caltrans. He’s working tirelessly to convince state leaders to include foamed asphalt CIR in their specifications. (Caltrans has only identified emulsion CIR as a non-standard provision in its specs until now.)
Foamed asphalt CIR actually binds the aggregate using less water and less asphalt binder, and cures in just two or three days compared with nearly two weeks with emulsion.
Caltrans has agreed to a pilot project for foamed asphalt CIR this summer on Highway 116 in Sonoma County. Graniterock is finalizing its foamed asphalt CIR working NSSP (Non Standard Special Provision), which can be used as a template for future CIR jobs.
Dennis grew up watching his ambitious father, Mike McElroy, make a name for himself in the San Francisco Bay Area construction industry. Mike, a natural leader and deal maker, ran his own grinding company, FMG, and introduced foamed asphalt CIR to California in 2010.
While it might appear all roads would have led Dennis, 27, to a construction career, that wasn’t the case. In fact, he resisted joining the field for a long time.
“As a kid, I always told my dad I never wanted to work in construction,” he said. “It wasn’t something I was interested in until later.”
Dennis tried other avenues, including community college and a position at Fox Racing in Morgan Hill, before admitting construction might be the right fit after all.
But when he asked his dad for a job, it wasn’t straight to the top.
Far from it.
Dennis started at FMG washing trucks and sweeping the shop floor.
“My dad was adamant I start at the bottom and learn everyone’s role,” he said. “There were no handouts or favoritism.”
After about a year he joined Operating Engineers and worked at FMG as a ground man, coordinating trucks and assisting the grinding operator.
He also spent time as a laborer on FMG’s paving and CIR crews – striping, shoveling and spreading sand.
In due time, the quiet and introverted young man had absorbed quite a bit about how to run a job and lead a crew, and was ready to take on the challenge himself.
His test was a nearly $9 million overlay project for the city of Fremont, covering 14 streets in a short time period.
“That job taught me how to build a good relationship with the owner,” Dennis said. “I was stressed out, but learned a lot.”
He joined Graniterock in early 2014 when Graniterock acquired FMG, and he quickly jumped into the CIR business with FMG’s Wirtgen 3800CR machines.
While Mike ended up leaving Graniterock, Dennis stayed on and embraced the CIR method his father had worked hard to establish.
His intelligence and passion for the technology make Dennis the ideal person to carry on his father’s legacy and win over skeptics.
“A small piece of his passion for CIR is an extension of his father,” said Graniterock Area Manager Bill Moody. “Dennis is eager to learn and he takes a lot of initiative. He’s shown great ownership in taking over the development of Graniterock’s CIR program. In addition, he’s very capable and puts people at ease.”
Dennis lives in San Jose with his girlfriend Shannon. They like to ride his Harley and get out of town on weekends. You can also find him fishing with his father and younger brother Daniel.
And yes, they do talk about work. A lot.
“My dad has definitely been a mentor to me,” Dennis said. “I want to continue what he started.”


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Glasgow coma scale
The Glasgow Scale is a widely extended global neurological assessment tool. It is used in general lines to assess the level of consciousness of a patient with some type of brain damage . Thanks to this tool, medical personnel can quantify three key parameters to determine the diagnosis: the ocular response, the verbal response and the motor response.
In its beginnings, the Glasgow Scale was used to determine the severity of those patients who had suffered a head injury. Today his field is vastly broader; This tool is used routinely to assess altered states of consciousness, such as the depth of coma.
What is the Glasgow Scale?
The Glasgow Scale is a tool used in the medical field to quantify the level of consciousness of a certain individual . It is therefore the tool used to establish the prognosis of an injury that has caused some type of brain damage.
The origin of the Glasgow Scale (or consciousness) dates back to the 1970s. It was designed by two neurosurgeon doctors at Glasgow Hospital in England. From then on, this tool began to be used in different hospitals in the United Kingdom and, given its efficiency and effectiveness, its use spread throughout the world.
When a person suffers a trauma to the head, a neurological examination performed as quickly as possible is essential for their recovery. One of the most important aspects is the level of consciousness, for which the Scale of Consciousness is fundamental. In this way, based on the score obtained by the patient, the doctor can know the severity of the injury in question.
This tool is also used to determine deep coma states and evaluate their evolution.
How does the Glasgow Scale work?
This tool allows the measurement of the level of consciousness, as well as the cognitive state, of a certain person. To do this, it evaluates three fundamental aspects: motor response, verbal response and eye opening .
The values provided oscillate between 3 and 15 points ; 3 points correspond to the minimum possible, compatible with a deep coma, while 15 points are given when the patient does not present any type of cerebral affectation.
Interpretation of the glasgow coma scale
In order to open the eyes, it is an indispensable condition that the patient is awake; In addition, this tool takes into account whether or not it is attentive to the environment. It is an action that requires that the neurons of the brainstem, thalamus and hypothalamus , in addition to the reticular system, do not have any type of damage.
Depending on the degree of stimulation necessary to obtain a response from the patient , the doctor gives a higher or lower score to this category.
To avoid an error in the measurement of this parameter, it is essential to rule out injuries that may affect ocular opening in any way, such as trauma to the eyelids or facial paralysis.
If the eye opening is done spontaneously , the score is four points. Meanwhile, if the eye opening occurs when speaking, the score awarded is three points.
Meanwhile, if the patient opens his eyes only in response to pain, the score corresponding to this parameter is two points. And finally, if there is no eye opening to any stimulus, one point.
This category of the Glasgow scale assesses brain function at the global level. First, the doctor orders a series of simple tasks to assess the patient’s response .
In the event that this does not obey the assigned tasks, the doctor proceeds to apply different painful stimuli to determine whether or not there is any type of movement.
The motor response score is given as follows. If the patient obeys all the commands related to the movement of various areas of his body, he scores a total of six points.
In case you localize the pain, the score is five points. If there is a withdrawal of pain, you are awarded four points. If abnormal flexion occurs, three points; and if an abnormal extension occurs, a colon. Finally, if the patient does not give any kind of response, he is awarded only one point.
Regarding the verbal response, it includes two processes that are very important; the ability to understand a given instruction and to respond to it .
Thus, the main objective of this category of the Glasgow scale is to assess the level of consciousness and alertness of the patient, with himself and with the environment.
In addition, the evaluation of the verbal response allows to determine if there is any type of injury in the language centers.
If the patient is fully oriented, the score is five points. Meanwhile, if you are confused, your score is four points. If the words are inappropriate, three points. In case you make incomprehensible sounds, colon. And, if there is no answer, one point.
Glasgow Scale Indices
The Glasgow Scale is divided into a total of three categories, as we have indicated in the previous section. The maximum and normal score is 15, while the minimum is 3.
In general terms, a mild head injury is considered to be one with a score of between 13 and 15 points. Meanwhile, it is moderate when the score ranges between 9 and 12 points. A score on the Consciousness scale less than 8 implies a situation of a serious nature, in some cases critical.
Glasgow Impact Scale
There is also a series of evolutionary scale of the coma; the most widely used in the health field is the Glasgow impact scale. This divides the patient’s state into four states, plus death; each of the degrees is characterized by a different social and labor integration.
- Vegetative state: the patient is completely unable to interact in any way with the environment around him.
- Severe disability: the patient can obey orders, but is not able to live independently.
- Moderate disability: the patient can live independently, but is unable to resume his professional life.
- Good recovery
A prolonged state of unconsciousness is known as coma, in which the patient does not respond to any type of stimulus from the environment, not even pain.
Types of coma
There are different types of coma, each with its own characteristics and prognosis.
- Toxic-metabolic encephalopathy : it is known as an acute condition in which the patient presents symptoms of confusion and / or delirium. The most common causes of this type of coma are systemic diseases, infections, and failure of certain organs.
- Anoxic brain injuries: it is a brain condition caused by the total lack of oxygen to this organ, which can cause cell death of tissues. In the vast majority of cases, it responds to cardiac arrest.
- Vegetative state: it is a serious state of unconsciousness. The person is nowhere near aware of his surroundings and is completely incapable of making any voluntary movement.
- Captivity syndrome: it is a neurological condition that occurs very infrequently. The patient is only able to move his eyes, but remains awake and alert.
- Brain death: an irreversible situation in which all brain functions die. The prognosis is extremely complicated.
- Induced: the induced coma is used to protect the brain inflammation after suffering a given lesion. Thus, the patient receives a controlled dose of an anesthetic to cause lack of consciousness.
Causes of glasgow coma
In relation to the causes that give rise to a comatose state ( coma scale ), it is estimated that in more than 50% of cases patients have suffered some type of head trauma or a disorder related to the circulatory system in the brain. Here are the causes that most often lead to a coma.
- A head injury can cause the brain to swell. As a result of the swelling, pressure is generated against the skull, which can damage the RAS, the reticular activation system; It is the area of the brain responsible for awareness and arousal.
- Bleeding in certain areas of the brain can cause a glasgow coma , due to swelling of the organ, thus leading to damage to the brainstem and RAS. Some of the most common causes of bleeding in the brain are high blood pressure, brain aneurysms, and tumors.
Blood sugar levels
- In people with diabetes, a coma can occur when blood sugar levels remain very high for a long period of time; it is what is known as hyperglycemia. In some cases, hypoglycemia , very low blood sugar levels, can also lead to a coma. In both situations the situation is reversible once the blood sugar levels are corrected.
- Oxygen is essential for the brain to function properly. When cardiac arrest occurs, there is a sudden cut in blood flow and oxygen to the brain; This is what is known as hypoxia .
- Certain infections of the central nervous system , such as meningitis , are another possible cause of a coma. Although meningitis can occur in people of all ages, it is much more common in children.
Glasgow coma prognosis
The prognosis of a coma varies considerably between patients. It largely depends on the causes that have led to this situation, as well as the time the patient remains in a coma.
In general, those comas that occur as a result of intoxication by substances such as drugs have a very high recovery rate. Similarly, those comas that arise from trauma and head injuries have a higher recovery rate than those related to lack of oxygen.
In the healthcare setting, precision is of the utmost importance in determining the severity of different disorders. Thus, the Glasgow Scale makes it possible to diagnose with great precision and certainty patients who are in a coma or who have suffered some type of head injury, thus avoiding the use of ambiguous terms such as “the patient is drowsy.”
The Scoring Scale (Glasgow) assesses three key aspects and, furthermore, being a non-invasive tool, it can be used as many times as necessary to check the patient’s progress .
Hello Readers, I am Nikki Bella a Psychology student. I have always been concerned about human behavior and the mental processes that lead us to act and think the way we do. My collaboration as an editor in the psychology area of Well Being Pole has allowed me to investigate further and expand my knowledge in the field of mental health; I have also acquired great knowledge about physical health and well-being, two fundamental bases that are directly related and are part of all mental health.

domain: medical


Tesla Motors is an American-based company that manufactures electric trains and cars at affordable prices in the American, European and Asian markets. Its name was adopted from an electrical engineer and physicist Nikola Tesla. This paper will discuss the competitive and financial analysis of Tesla Motors.
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In September 2014, the company had a total net income of US$ 74,709. The company’s records show that this income originated from a 464% profit increase (Tesla, 2013). The company has experienced a rapid increase in its assets. For instance, within five years, the value of the assets increased from 330.78 Million to 2.42 billion. From data taken from the cash flow statement in the year 2013, the company has undergone a general increase in profitability, as shown by the increase in revenue in 2010.
The income statement of tesla motors presented in quarterly data into thousands
The threat from new entrants
New electric car companies are emerging every day to compete for the share of the market. The company joined the electric company in 2003 and encountered several financial challenges that nearly led to its closure. Tesla faces threats, especially from well-established automobile companies that decide to expand their products to cover the electric car market (Marcovici, 2013). As the electric car market grows and becomes appealing to more consumers, new entrants are expected to increase and offer threats to Tesla (Mangram, 2013).
The bargaining power of buyers
The overall bargaining power of buyers is low significantly low because of the high costs of their products. Electric cars are very expensive, and therefore very few people buy them. However, government incentives and reduced costs of production are expected to increase purchases because they will lower the costs of electric cars.
Threat of substitution
Tesla’s heart of substitution is relatively low because its products are unique, and its innovations give it a competitive advantage over other companies. Possible threats to substitution include public transportation means such as trains and buses. However, many people prefer private means of transportation for their convenience. The increasing demand for electric cars is eradicating the threat of Tesla’s substitution (Marcovici, 2013).
The bargaining power of suppliers
The bargaining power of suppliers is low because of high competition among suppliers for Tesla supply contracts (Marcovici, 2013). The company purchases various components from more than 200 suppliers. Examples of Tesla’s main suppliers include Panasonic Corp, TI Automotive, Hope Global, Argent, ABC Group, and AGC Automotive (Mangram, 2013). Tesla’s diverse distribution channels also lower the bargaining power of suppliers.
as little as 3 hours
The intensity of existing rivalry
Currently, there is intense rivalry in the automotive industry because of the numerous players who offer different products to meet the needs of customers. However, the electric car industry has modest rivalry because Tesla has positioned itself as an authority through its unique and innovative products. The main Tesla’s competitors in the electric car industry include Nissan, BMW, Audi, Toyota, Ford, Opel, and Chevrolet (Marcovici, 2013).
Mangram, M. (2013). The Globalization of Tesla Motors: A Strategic Marketing Plan Analysis. Journal of Strategic Marketing, 4(10), 289-312.
Marcovici, M. (2013). The Tesla Motors way How to Build a Car Manufacturer from Scratch (1. Aufl., Neue Ausg. Ed.). Norderstedt: Books on Demand.
Tesla, N. (2013). A New System of Alternating Current Motors and Transformers and Other Essays. Lanham: Start Publishing LLC.


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Release on 2019-02-16 | by Elizabeth Carman,Neil Carman
Signs of Their Secret Intelligence
Author: Elizabeth Carman,Neil Carman
Category: Body, Mind & Spirit
Extraordinary findings about babies' awareness of birth, the womb, conception, heaven, choosing parents, and beyond. This evidence of consciousness before birth suggests the need for a new standard of medical care that includes the power of love. Learn to form a loving bond with your children, giving them a greater capacity to love and be loved.
Release on 2006-01 | by Will Ludwigsen,Matthew Warner
Author: Will Ludwigsen,Matthew Warner
Pubpsher: Lethe Press
Oscar Wilde wrote that "the real tragedies of life occur in such an inartistic manner that they hurt us by their entire lack of style." Not satisfied with that, Will Ludwigsen chooses instead to add humor and flair to the horrors that surround us. Why settle for the lesser of evils in your newspaper when you can read an entire book of stories about zombie-exploiting, plesiosaur-chopping, alien-dissecting, robotically-enhanced, lunatics instead? This premiere collection by Will Ludwigsen brings together thirteen of his best horror, mystery, and science fiction stories from magazines such as Weird Tales, Alfred Hitchcock's Mystery Magazine, and Cemetery Dance, plus three originals. Though the work of a single deranged author, these varied tales share a flippant disdain for common decency, courtesy, and sense. Witty and irreverent, they remind us that we have more hope than we think--if only because we have wit and irreverence.
Land of the Cosmic Race is a richly-detailed ethnographic account of the powerful role that race and color play in organizing the lives and thoughts of ordinary Mexicans. It presents a previously untold story of how individuals in contemporary urban Mexico construct their identities, attitudes, and practices in the context of a dominant national belief system. The book centers around Mexicans' engagement with three racialized pillars of Mexican national ideology - the promotion of race mixture, the assertion of an absence of racism in the country, and the marginalization of blackness in Mexico. The subjects of this book are mestizos - the mixed-race people of Mexico who are of Indigenous, African, and European ancestry and the intended consumers of this national ideology. Land of the Cosmic Race illustrates how Mexican mestizos navigate the sea of contradictions that arise when their everyday lived experiences conflict with the national stance and how they manage these paradoxes in a way that upholds, protects, and reproduces the national ideology. Drawing on a year of participant observation, over 110 interviews, and focus-groups from Veracruz, Mexico, Christina A. Sue offers rich insight into the relationship between race-based national ideology and the attitudes and behaviors of mixed-race Mexicans. Most importantly, she theorizes as to why elite-based ideology not only survives but actually thrives within the popular understandings and discourse of those over whom it is designed to govern.
A New Theory on the Functions of Black Holes and the Development of the Cosmic Brain
Author: Vincent L. Di Paolo
“What happens to the information of a star system when it enters a galactic black hole?” Stephen Hawking “What are the functions of black holes?” “What is the probability of other intelligent planets within our universe?” “How did the human brain develop? Where does intelligence come from?” “How does myelin permit higher learning?” “Did the Supreme Being create the cosmos? And where is the Supreme Being now?” ALL OF THESE QUESTIONS AND MORE ARE ANSWERED IN THIS BOOK! A MUST READ FOR ALL WHO SEEK HIGHER INTELLIGENCE!!!
This book covers the first 30 years of my life and God willing, I will write about the rest of the years while the sun still shines. Now that I have written my history I can say that there is far more left out than what was written. And then, we tend to see the past through rose-colored glasses, and that is our way of rationalizing our existence. Memories are sketchy at best and we all see things from their moccasins. I hope that my recollections can enrich your own. My children will have a reference point for their history and they will add to it for greater continuity. Life will become the beginning for a life that never ends.
Release on 2013-04-16 | by Elizabeth M. Carman,Neil J. Carman, Ph.D.
Spiritual Dimensions of Life before Birth
Author: Elizabeth M. Carman,Neil J. Carman, Ph.D.
Pubpsher: North Atlantic Books
Category: Body, Mind & Spirit
Where was your soul before you were born? If your soul is immortal, did it have a "life" prior to birth? Did you choose your life and parents? Is reincarnation real? Elizabeth and Neil Carman, the authors of Cosmic Cradle, address these questions through interviews with adults and children who report pre-birth experiences (PBEs) not based on regression, hypnosis, or drugs. Instead, interviewees recall their pre-birth existence completely sober and awake. In contrast to near-death experiences (NDEs), which have been well documented to show us what the soul experiences after death, PBEs throw light upon our lives before birth. People with NDEs sense that they "return home" when their spirits cross to the other side. What is the nature of this place we "return" to? PBEs suggest that we come from the same place we return to: we come from the Light and return to the Light. The same eternal "you" progresses through life before life, human life, and life after death. This new edition of Cosmic Cradle explores your soul's journey into your mother's womb--where your soul comes from, the origin and purpose of your life, and the process by which you entered an earthly body. In pre-birth communications, parents meet a soul seeking to cross over from the heavenly realm to human birth. Persons with pre-birth memories recall existence in a luminous world before birth, in which they preview the upcoming life with a Divine Planner, and recall how they journeyed to their mothers' wombs. Contents Foreword by Bernie Siegel, MD Introduction: Amnesia of Our Spiritual Origins Part One: Pre-Birth Memory 1. Children as Messengers 2. Memories of the Cosmic Cradle 3. “I Was in Your Tummy Twice” 4. Scanning Soul Plans: Contemporary Pre-Birth Memories 5. Welcome to Planet Earth 6. Shirley Temple and the Blue Bird 7. Our Soul as a Tiny Spaceship 8. I Saw All My Costumes Part Two: Pre-Birth Communications 9. Souls Waiting in the Wings for Birth 10. Soul as a Sphere of Light 11. Cosmic Conception 12. Miscarriages and Stillbirths in the Light of Pre-Birth Plans 13. Conversations with Unborn Children Part Three: Pre-Birth Wisdom down through History 14. Spirit-Children Down Under 15. Lodge of the Great Manitou 16. The Cosmic Designer 17. Travelers from the Light 18. Journey from Forgetting to Remembering From the Trade Paperback edition.
'There is no writer in the evangelical world that I admire and appreciate more.' - Billy Graham Philip Yancey's words---captured in his many bestselling books---have influenced the lives of millions of readers by strengthening their faith, building their hope, sparking their creativity, and challenging their comfort zones. If you're one of those readers, you know personally how his insights have affected your mind and heart. And if you're new to Yancey, you're in for a life-altering experience. These meditations---all drawn from the beloved and bestselling writings of the author---will take you through an entire year of Yancey's insight and imagination, covering a broad range of topics: * How to rediscover God through the wonders of nature, music, and romantic love * Why grace means you can't do anything to make God love you more or less * What happens when you cut through preconceptions to encounter the 'real' Jesus * How to renew your understanding and practice of prayer * Where you can see God in unexpected people and places * How to cope when life crashes in around you Every day, experience the best from a beloved author who, with freshness, clarity, and energy, has so brilliantly articulated God's wonderful but mysterious relationship with you. '
In Soul Babies, Mark Anthony Neal explains the complexities and contradictions of black life and culture after the end of the Civil Rights era. He traces the emergence of what he calls a "post-soul aesthetic," a transformation of values that marked a profound change in African American thought and experience. Lively and provocative, Soul Babies offers a valuable new way of thinking about black popular culture and the legacy of the sixties.
This book presents a biography of Abdus Salam, the first Muslim to win a Nobel Prize for Science (Physics 1979), who was nevertheless excommunicated and branded as a heretic in his own country. His achievements are often overlooked, even besmirched. Realizing that the whole world had to be his stage, he pioneered the International Centre for Theoretical Physics in Trieste, a vital focus of Third World science which remains as his monument. A staunch Muslim, he was ashamed of the decline of science in the heritage of Islam, and struggled doggedly to restore it to its former glory. Undermined by his excommunication, these valiant efforts were doomed.


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If you submit a cargo claim (for goods exported by a shipping company), you do not need to send your original documents to our office in the post. Instead, you can simply upload copies of your receipts and digital export documents during the registration of your claim. These digital export documents are sufficient to prove that your goods have been exported to a non-EU country.
Find out how to register your cargo claim here.
If you have exported your goods by airplane, find out what to do here.

domain: economics


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Diabetes Treatment Self-Hypnosis MP3 Download
- Guaranteed to bring more control over the symptoms of Diabetes
- It’s easy to use – All you do, to feel more energized, is listen
- Have easier and more restful sleep
- ‘Help With Diabetes’ Easy to order – MP3 download
- Created by Duncan McColl, a world class hypnotherapist
Exceptional self-hypnosis recording by a great hypnotherapist
‘Help With Diabetes’ is a self-hypnosis recording from Duncan McColl. It comes out of all that he has learned over tens of years, and is designed to help you gain more control of the disease’s symptoms.
Diabetes as a lack of energy
As you will know, diabetes is a disease for which no cure has yet emerged, but methods of controlling the effects of the disease have been discovered. If you have diabetes your blood sugar levels will be too high unless you apply control methods. The blood sugar type is glucose and with the help of the hormone insulin it can be taken in by your body cells, and they use the glucose as a source of energy. With diabetes there is either no insulin produced, or insufficient insulin, or your body does not make full use of the insulin. The end result is lack of energy for body cells. And there are other major problems that can develop.
A miracle cure has not yet been found
The methods of managing the disease and reducing its damaging effects on the body include insulin injection, exercise regimes and nutrition control. These are all aimed at controlling the blood sugar level within safe limits. No one knows how to simply eliminate the disease.
Getting creative to stay healthy
Although it all sounds grim, and no one wants to suffer from diabetes, many people with this problem find there are some compensations. They have realized that because of the care they have to take to look after themselves, they tend to be healthier than many and to have well cared for bodies. People who are managing their diabetes symptoms have to be self-aware and in tune with their bodies. And all that shuffling of exercise, nutrition, medical visits, insulin control and glucose level checks requires a lot of creative thinking to manage the time available for all this. They also become experts in nutrition, and adept at calculation.
Making use of hypnotherapy to control the symptoms
When you listen to Duncan McColl’s voice on ‘Help With Diabetes’ you will find yourself beginning to relax. His first aim is to teach you how to relax deeply. When you enter a state of deep body/mind relaxation your unconscious mind becomes very receptive and open: it can take up new ideas, focus more tightly on a task, and be much more creative. The creativity might even be applied to improving your glucose/insulin balance.
Listening and learning
Duncan can then proceed to his target, delivering carefully designed hypnotic suggestions that your unconscious mind can take in, and modify to suit your need to achieve a better control of blood glucose. Basic beliefs and habits are held by the unconscious and this is an opportunity for you to throw out any negative, limiting behaviors and introduce more positive, life enhancing thoughts.
Taking benefits from ‘Help With Diabetes’
Each time you listen to the recording you will become more adept at deep relaxation and how to use it in creative ways. You will find that your goal setting and problem solving, and your approach to nutrition and exercise will improve. Your sleep patterns will improve and sleep will take on healing qualities. And the diabetes symptoms will recede as you manipulate the control factors. We are so sure of this that we offer a full guarantee.
A free bonus track utilizing Whisper subliminal recording comes with the CD version.Instructions on using this come with the CD.
How to get the results you want
The method is effortless: you listen to the recording in bed, every night, as you go to sleep. You may well fall asleep before the recording is over. This is OK. You will absorb Duncan McColl’s ideas through your always-active unconscious mind, while your conscious mind is tuned out.
Arrange to listen to the recording twice a week at some other times: times when you can arrange for no interruptions. We recommend a quiet, safe place where you can sit comfortably, with support for your back, with your feet firmly on the floor, and your hands on your lap. You may well fall asleep – it is OK to do so.
Help with your diabetes comes by simply listening.
Many people notice benefits within a couple of weeks or so. If a period of 30 days of following our advice on ‘How to get the results you want’ does not get you any benefit, we will gladly refund your money. It really is a Money-back Guarantee.


Jessica Collins Cast As Avery Clark On The Young And The Restless
According to TV Guide, actress Jessica Collins, who once played Dinah Lee Mayberry on “Loving,” has been cast as new character, Avery Clark, on “The Young and the Restless.” Debuting July 27, Avery will be a high-powered attorney hired by Victor Newman (Eric Braeden) to represent Sharon Newman (Sharon Case).
Are you excited about Jessica Collins coming to “Y&R?” Let Soaps.com know by casting a vote in the snap poll below. Feel free to comment as well.
Read about the other actress joining "Y&R" through Jessica Heap Cast As Eden Baldwin On The Young And The Restless. Join us on Twitter @soapoperafan and Facebook. Come tweet and Facebook with us about "The Young and the Restless," all the other soap operas, "Glee" "Grey's Anatomy," and "Vampire Diaries!"


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Email: firstname.lastname@example.org | Tel: 06 - 303 653 26 | |
Pink herringbone floor
The bathroom is not very large but the mixture of tiles and colors gives it a special effect.
Luxurious hotel style
Gold and sandy colors
Gold and sandy colors make a very relaxing and elegant bathroom in this Amsterdam apartment.
The floor and walls were made of the same smooth material and underfloor heating gives such comfort.
This combination was made of old materials (Vintage tiles) with ultramodern elements such as a steel sink and taps from Boffi Alape.
Bathroom with Eastern charm
The design, lay-out and realization of a new bathroom in this family house.
© IJzersterk Interieurontwerp

domain: artistic


Add Energy celebrates new projects worth $4M and 103% increase in their workforce
20 Feb 2018
Add Energy, the international energy consultancy provider, has more than doubled its workforce in Aberdeen and Houston as a result of recent global contract wins and innovative software developments.
In what has proved to be one of the most successful year’s that the company has enjoyed since it was established over 30 years ago, Add Energy has increased its workforce by 103% in 12 months; from 79 last January to 160 this year with plans to recruit a further 30 personnel over the next six months, increasing the team in offices across the globe.
The buoyant year has allowed the company to secure jobs for the next three years in its Asset and Integrity Management Division, despite the current low oil price environment. This has included senior management appointments made in Saudi, Houston and Muscat, further bolstering Add Energy’s global presence, and allowing the expert team to provide in-country support for on-going projects and business development. As well as this, the energy consultancy also increased its senior leadership team by 40% in the Asset Management HQ in Aberdeen, with the appointment of Dr Damon Bowler (Manager of Projects) and Marc Tichelaar (Operations Manager).
These most recent appointments are testament to Add Energy’s commitment to their client projects and on-going growth plans for the company.
With over 25 years of asset management experience, Dr Bowler has worked in the oil and gas industry in various roles, and has a diverse range of technical, business and management skills.
This includes over 15 years working for Shell in process safety, operational excellence, reliability, maintenance, operations and projects, within onshore and offshore production assets, gas plants and LNG. He also has 10 years of maintenance, reliability and technical / management consultancy experience within numerous industries including electricity & power, oil & gas, refining and petrochemicals.
Dr Bowler is also a committed safety leader with a demonstrable passion for process safety. He is the chair of Step Change in Safety’s hydrocarbon release prevention workgroup and is currently leading the development and roll-out of new best practice guidelines for the offshore industry.
Trained in the mechanical engineering and aerospace technology field, Marc Tichelaar has worked in the reliability and maintenance engineering disciplines in upstream Oil and Gas for the past 20 years.
This includes Maintenance and Reliability consultancy work for major operators and drilling contractors in Europe, Asia and Middle East. Marc then moved on to manage the Operations of a rig inspection, consultancy, and training company in Singapore, and later moved to Aberdeen as the General Manager of the same company. At present Marc is fulfilling the role of Operations Manager for Add Energy Asset and Integrity Management, supporting the Add Energy team to ensure timely delivery of quality services globally.
Peter Adam, Executive Vice President, Add Energy commented: “We are thrilled to have increased the headcount in our Aberdeen office, especially at a time when many companies are looking to reduce personnel. We have endeavoured to recruit locally during the process to ensure opportunities for both the development and employment of graduate engineers in the regions we work in.”
A major long-term agreement with BP worth over £20m, as well as new projects across the globe including UK, North America, Monaco, Indonesia, Tunisia, Denmark and Austria have been at the forefront of the expansion. Add Energy has also recently secured a commercial partnership in Saudi Arabia, allowing the ambitious team to trade in Saudi and help them in qualifying as a supplier for Saudi Aramco.
These contracts, as well as six new clients acquired at the end of last year, totalling over £4,089,000, sees the energy consultancy firm expand into power generation and mining, as well as continue its work providing solutions to drilling contractors, FPSOs and oil and gas operators.
OptiBoM™ is the industry leading BoMs database containing over 9 million records of spare part data. Designed to bridge the gap between operations and procurement, the smart database ensures that critical spare part information is available on demand, so that part sourcing can be executed efficiently and on time.
Aim-Hi™ is a cloud-based software, providing an interactive real time dashboard for analysing and managing key performance indicators (KPIs) relating to maintenance. The maintenance management software is compatible with any Computerized Maintenance Management System (CMMS) and able to calculate Key Performance Indicators (KPIs) at the click of a button.
Looking to the year ahead, Peter Adam concluded: “For Add Energy, 2018 looks like a solid year of growth. From a business perspective we will be looking to consolidate what we have, continue to recruit talented personnel and expand our overseas operations.”
He added: “I would anticipate that we will have particularly high growth in Houston and in the Middle East market during 2018.”


Sounds like a symphony of rainsticks out there — for good reason — and North Idaho could break its record for most precipitation in February.
All that rain is causing reports of flooding and damaged roads around the region, prompting a flood warning for the region, including Bonner, Boundary and Kootenai counties.
Since Feb. 1, Coeur d’Alene had gotten 4.76 inches of precipitation, Press meteorologist Randy Mann said Thursday afternoon. He said that could increase to 5 inches by the time you read this story. Sandpoint received about 1.67 inches of rain on Thursday alone.
“The all-time record is 6.49 inches set in 1940,” Mann said. “If we get another inch and a half of moisture, we’ll do it.”
As of 4 p.m. Thursday, Mann said the storm had spit out 1.56 inches of rain, and it was still coming down.
Moving into the weekend, Mann said there could be a small break from the rain later in the day today, but starting late tonight, Coeur d’Alene will see a mix of rain and snow, on and off, throughout the weekend.
Even more precipitation is expected next week, but “I don’t think it will be as intense as this week,” Mann said.
The National Weather Service issued a flood warning due to rain and snowmelt in the region. The warning is in effect until 11:15 a.m. Friday, Feb. 17.
Local law enforcement officials are reporting numerous flood problems across eastern Washington and North Idaho from the combination of heavy rain, snow melt, and clogged culverts, according to the National Weather Service. Several roads are experiencing some degree of flooding and motorists are urged to use caution when they see water over the road.
Flooding problems were expected to continue through the day as additional light rain falls combined with delayed runoff from overnight rains and melting snow.
There have been several reports of damaged roads from flooding Thursday, NWS officials said in the Nixle report. Residents are urged to use caution if they come across a flooded road and to not drive through the flood waters unless they are certain it is safe and passable.
Additional rainfall amounts near a quarter of an inch will be possible by Friday morning with locally up to half an inch. Drier weather is expected to return to the region Friday.
Staff writer Caroline Lobsinger contributed to this report. She can be reached at firstname.lastname@example.org or @CarolDailyBee on Twitter.


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So the book I illustrated is moving forward to publication and I need to come up with a bio. ack!
Some background...my friend wrote a story that she decided to publish as a childrens book and she was looking for an illustrator. I had gotten back to playing with drawings and paintings after a long hiatus and had made them a keepsake box as a gift. After viewing that and some of my other work she asked me to illustrate her story. We had some obstacles (new baby, their water pump on their well broke) but the drawings are turned in and scanned and I need to get them a bio.
I'm used to writing theatre bio's b/c that was...well...what I do. I act. This is newer for me and I'm working it out. A bit harder than I thought it was going to be but I'll get there.
I'll let everyone know when the book is out :)


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Click on the map to display elevation.
Name: Doues topographic map, elevation, terrain.
Location: Doues, Aosta Valley, Italy (45.78958 7.25439 45.86060 7.31988)
Average elevation: 1,661 m
Minimum elevation: 757 m
Maximum elevation: 3,073 m
How is the collected data used?

domain: travel


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Thursday, February 18, 2010
Sketches done for our biweekly drawing challenge. For this one we have to chose a character archetype and then present it in different styles. I chose the "trickster" archetype and wanted to represent it as a fox type of character...
Wednesday, February 17, 2010
Yet another bit of Mass Effect 2 fan art. Tali has always been my favorite character in the series. As always the final will be up on my Deviantart gallery heh...
Friday, February 12, 2010
Work in progress of some Mass Effect 2 fan art. Its of my femShep and her two partners in crime. Should be pretty obvious who I chose as her LI hehehe...


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The huge and stunning nation of Canada, sometimes known as “the Great White North,” is home to thousands of attractions for both tourists and residents. Canada is a vast country with imposing mountains, breathtaking beaches, peaceful woods, open grasslands, and the Arctic tundra.
Canada is host to a mosaic of diverse societies, despite the fact that a large portion of the country is of British and French heritage. Its cuisine, artwork, architecture, and tourist attractions all reflect this.
Canada provides something for everyone, whether you like to hike through a major, busy metropolis, explore forests and rivers, go camping, or go snowboarding.
Read this article below to find more about Canada, from the best Canadian Immigration consultants in India.
Canada is home to some of the most stunning and diverse cities in the entire globe.
Calgary, the largest city in Alberta, is positioned between the Canadian Prairies and the Canadian Rockies’ highlands. After local oil was found in the early 1900s, Calgary grew into one of Canada’s greatest metropolitan regions, drawing tens of thousands of visitors each year to its renowned rodeo competition, the Calgary Stampede.
Ottawa, the capital of Canada, is situated in southeast Ontario at the meeting point of the Ottawa, Gatineau, and Rideau rivers. As the capital of the country, Ottawa is the location of numerous commercial, federal, and financial institutions, notably Parliament Hill, the government’s seat where the official Changing of the Guard occurs every day in the summer.
The Whistler resort, the biggest and most well-known alpine ski resort in North America, is set against the breathtaking Whistler and Blackcomb mountains. It takes less than two hours to travel from Vancouver to Whistler, which is situated in British Columbia’s Coast Mountains along the Sea-to-Sky Highway, Canada’s most picturesque road.
Vancouver, a thriving port on British Columbia’s west coast, is one of the most populated and culturally diverse cities in Canada. Since it is surrounded by hills and has flourishing art, theatrical, and entertainment sectors, it is a well-liked location for movies.
Despite being the provincial capital of Quebec in eastern Canada, Quebec City appears more like a quaint European village due to its French heritage, history, and languages.
The wildlife species in Canada are one of the most varied in the world, and with its 46 national parks and 2 million lakes, you won’t be running out of locations to view it when you visit. Canada is home to 70% of the world’s last remaining wilderness.
The wonderful fauna that you can only view when you visit Canada or neighboring regions thrives in the diverse landscape of Canada, which includes the Rocky Mountains, deep woods, glaziers, and grassland landscapes. The tiniest pika to the biggest deer, wild dog, and geese in the world may all be found in Canada.
There are probably thousands of hiking paths, scores of national parks, and a plethora of lakes in Canada. The sheer quantity and variety of Canada’s lakes are what truly distinguishes them. The 82,100 km2 Lake Superior, which abuts Ontario, is the largest freshwater lake on the planet by total area.
Another well-known tourist destination with waters that are recognized for being clear is Lake Louise in Alberta. The Spotted Lake in British Columbia is a peculiar location with mineral-filled water layers that provide the lake with a variety of colors.
Being one of the biggest national parks in the country, Banff National Park can potentially spend up to five days exploring in its entirety. The Rocky Mountains, Louise Lake, with its crystal clear water, and, of course, the amazing biodiversity that lives there, including grizzly bears, cougars, wolverines, elk, bighorn sheep, and moose, as well as hundreds of bird species, are among the natural wonders that draw nature lovers to Canada, particularly to Banff. In Banff, you may do canoeing, hiking, picking, mountain climbing, and horseback riding, among other sports.
Jasper is up next! Only 290 kilometers separate Jasper from Banff. As you depart Banff, make sure to visit Yoho National Park as well to see the turquoise river and engage in a variety of outdoor pursuits like hiking, paddle boarding, mountain biking, kayaking, and more. Travel up to Jasper, Alberta, and, if you can, a camp for one night there. The next morning, watch the sunset, and then spend a few days visiting the glacier fields, Granite Mountains, and wildlife viewing.
Wapusk, which means “white bear,” is the home of the magnificent polar bear, as you’ve probably surmised by this point.
This park is unique since it is a true wilderness area that is inaccessible by car. The nearest towns to the park are Churchill and Gilliam. From there, authorized operators can bring you on a guided tour of the area by boat, snowmobile, airplane, or dog team. Wild polar bears can be seen in their natural habitat, and at dusk, you may even catch a glimpse of the magnificent Aurora lights.
Are you surprised that this is on the ranking? Ensure you travel south through stunningly green British Columbia if you’d want to end your journey a tiny bit closer to civilization; you’ll eventually arrive in Vancouver.
Travel by ferry to picturesque Vancouver Island, where you may choose from hundreds of campgrounds in national parks spread around the island. Go trekking in the amazing Strathcona Provincial Park after viewing 1,000-year-old trees in MacMillan Provincial Park.
The island is filled with charming tiny villages and bigger ones with all of the facilities someone could require, and there are probably thousands of attractions and destinations to explore there.
Do you want to call Canada your home? Click here to find your eligibility for the Canadian PR Visa.
Most individuals do not think of Canada when they see golden beaches; instead, they picture winter and bitter cold.
The beach at Skaha in British Columbia is lovely and ideal for families. You’ll witness throngs of people of all ages here taking part in summertime activities like volleyball, swimming, tanning, and sunbathing.
Even a humming beach exists in Canada, on Prince Edward Island. The silica and quartz that make up The Singing Sands provide a gentle, calming sound as the wind is blowing over them.
It is essential to pay a visit to Canada’s marine provinces. The world-class seafood and vibrant, picturesque communities of Nova Scotia, Prince Edward Island, Saskatchewan, Newfoundland, and Labrador are among their claims to fame.
Canadian Tourist Visa
Before you begin the application process for a tourist visa to Canada, you ought to be cognizant that all travelers, regardless of their country of origin, must have a current passport (or an unabridged birth certificate inside the case of kids from specific countries) in order to obtain the Canadian border.
As you go through border crossings or airport security checkpoints, visa and passport control officials must stamp your passport on an open page.
Many nations, including the USA and EU nations, simply need to register for an Electronic Travel Authorization (eTA) 72 hours before their trip to Canada. These nations are not required to apply for a visiting visa to Canada.
Those who are not excluded must personally appear at the Canadian embassy in the nation where they now live. An embassy expert performs a biometric screening and verifies the validity of the travel documents that you need to gather and provide.
Young people from over 30 countries have a fantastic chance to be employed briefly for up to 12 or 24 months depending on their origin country thanks to the Working Holiday visa. They can operate at a resort or vacation spot or earn money while traveling around Canada thanks to the work permit. Additionally, it offers priceless Canadian job experience that may be used in the future to remain in Canada permanently.
Your application will be added to a pool of candidates after your profile is complete. You will file for an open work permit if your application for a Canadian Working Holiday Visa is accepted. With an open work permit, you can work in Canada for any authorized employer (excluding Quebec). Sadly, if you have dependents, they cannot travel with you on an IEC Working Holiday Visa.
Traveling or relocating to a new country by yourself can be hectic, provided the number of rules and regulations. Plus, the application form should be flawless, or else the form might get canceled.
But with the help of our experts, the best Canadian Visa Consultants in India,
you can definitely earn success in your Canadian PR Visa application process and relocate to your dream country quickly.

domain: geography