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How To Add Page Numbers to PDF Online?
Easy-to-use PDF software
When writing a book, is there a minimum amount of pages that it should have?
My thoughts on this are not very popular, but I believe the answer is what my Advanced Writing teacher told me about paper length and I think that extends to books and novels as well. “It should me no shorter or longer than it has to be.” A lot of people say 300 pages, but for some books, that is way too long, as in t shouldn't be books at all but maybe short stories or novellas. If it’s a writer I love, like Stephen King, I feel like the answer is “the longer the better.” Although there have been a few books of his I wasn’t crazy about, Under The Dome being the one that comes to mind. I liked the premise of the book, but it didn’t really go anywhere for me. And as some have said, Stephen King would probably get a 2.7 from the east German judge because his dismounts or endings can be not so great. But, for the most part, the joy is in the journey. Right now I am rereading his Wolves of the Calla which weighs in at 246,605 words. I think that is right fine as a novel length, but for me over the years it’s more about the experience than it is about “finishing” it. Once you finish your book or novel, and get a reader or two, t will tell you if it’s too long or short. For me, more often, if I don’t like the premise of the story or it lacks cohesion,it’s difficult to read no matter what length it is. If the story is interesting to me, then it can never be too long.
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Add Page Numbers to PDF: All You Need to Know
So I assume there are, on average, about 1,000 pages of a novel. If a novel has 600 pages (i.e. has about 15,000 words, giving it a word count of 300,000, or the same as one full novel) it is about 600 pages of content, or roughly three or four short stories. If it has 400 pages it's 800 pages of content, or roughly three short stories per book, or roughly 10 novellas. The ratio of content to content is roughly 1:2. A typical, hardbound, “novel” takes up about 100-200 pages. One of the reasons that novella and novella-length stories tend to be smaller is because they are usually shorter than 1,000 words. Let me say that again: one page = ~30 words. So we are essentially talking about pages per novella-length work. And this is where I'll get my 1:2 ratio. If your novel takes up 1,000 pages, the.


text: This wonderful home is located on the Gold Coast of Australia. The beautiful Australian home pictures really moved me and at once I knew that I had to share with my readers. I love the “white” theme and how it flows through the house. To me it provides a clean respite in which to live and focus one’s life. Then there is the blue color. Blue is one of my favorite colors and to me provides a sense of serenity. The designers were able to work in blue in almost each room of the home.

domain: design


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The grocer is planning to offload its Thai and Malaysian operations for £8.2bn, which would trigger a potential £5bn return of capital to shareholders.
Another £2.5bn worth of proceeds from the sale will be used for the elimination of the pension funding deficit.
The deal, alongside plans to sell of the Polish division, comes as part of a wider strategy to get focus on the UK and Ireland business while it will also strengthen the firm’s financial position.
Covering around 2,000 stores under the Lotus brand, the takeover was agreed earlier this year.
In its half-year results published last month, the FTSE 100 firm hiked its dividend 21% after reporting strong sales, profits and cashflow thanks to a surge in demand during the pandemic.

domain: news


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About this product
Our version of classic root beer soda with a twist! Created to be enjoyed on top of a stony mountain. Made with clear distillate, pure cane sugar and lots of love. Ingredients: Carbonated Water, Sugar, Caramel Color, Natural Flavor, Lactic Acid, Quillaja Saponaria, Cannabis Distillate, Potassium Sorbate (preservative), Sodium Benzoate (preservative). Nutrition Facts: Amount per container: Calories 100, Fat Cal. 0, Total Fat 0g (0% DV), Sat. Fat 0g (0% DV), Trans Fat 0g, Cholest. 0mg (0% DV), Sodium 10mg (0% DV), Total Carb. 24g (8% DV), Dietary Fiber 0g (0% DV), Sugars 24 (44% DV), Protein 0g, Potassium 13mg (0% DV), Vitamin C (0% DV), Calcium (0% DV), Iron (0% DV).
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domain: food


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As a graduate of St. Vincent’s Hospital School of Nursing, Ms. Farrow began work as a registered nurse caring for floor patients and then in neurocritical care prior to embarking on a career as a neuroendovascular RN at Beth Israel Hospital-North in New York City. She proceeded to complete her MSN degree at Columbia University School of Nursing and became a board certified Acute Care Nurse Practitioner in 2003. Ms. Farrow has since been the Nurse Practitioner for the Department of Neurological Surgery at New York Presbyterian Hospital-Columbia Medical Center. Currently, in collaboration with attending and resident physicians, she manages the pre- and post-surgical care of the adult inpatient neurosurgical service. She also functions as a liaison among the interdisciplinary members of the team, interfacing and directing various aspects of the patient’s holistic care. Her academic interests focus on patient and nursing education in neurosurgical and neurovascular disease. Her accomplishments include item writing for the ANCC Acute Care Nurse Practitioner exam, lecturing in various forums, and recent co-authoring of a publication in the Journal of Neurosurgery and in the upcoming Textbook of Endovascular Surgical Neuroradiology.
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domain: health


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Passive income is something that many business owners aspire to have. The idea of earning money whilst not doing any extra work is incredibly appealing. The term ‘passive’ suggests that you could be sitting on a beach and permanently not doing anything to generate that income.
But passive income isn’t entirely passive. It’s true that once you create the content, you might not have to do anything to recreate that content, but you do still have to market and promote it.
A book is a classic example. You can spend a year to write a book, but then once it’s written, you can sell it over and over again, with no extra work. However, it takes you a year before you make any money, and you still have to promote it - because people can only buy things if you promote them!
Passive income products are generally lower cost. Things like an ebook for £10 or a prerecorded workshop that you initially deliver live but then record and sell on afterwards.
Think about what you can sell, how much you can sell it for and who much work is involved in creating it. A course, for example, can take many hours of work to develop and market.
People aren’t going to buy from you cold on social media; they’re going to purchase from you through your email list. Generally, your list will convert at 1-2%. If you want to sell passive income products, you need to build a list before you sell - and it can take a year or more before your list is a suitable size.
It’s incredible how long it takes, especially if you’re doing it organically. You also need to factor in the time it will take you to engage with that list and keep your subscribers active and engaged with you.
There are so many passive products you can create. But it’s no good creating loads of different options if they don’t suit your business model. So know what you want to create. Are you looking to create a group program or offer a course? Do you want to launch with an open and close the cart period regularly, or are you thinking about using an evergreen model, where people come into your list and ultimately buy through your emails?
Not all passive income products are quick to create. There’s also a lot to factor in with the creation and marketing processes involved. It isn’t just about the product itself either. You may want to also run Facebook ads for it as well. How many people do you need to convert, to make that worth doing? It takes a lot of time to create the content and work out the promotions.
For example, my hour-long masterclasses sell for £27. I turn up to the class, have to produce all the content and create the promotions. You then have to make sure all the content works properly and it’s all functioning, especially if you’re doing all the tech yourself. It’s a lot of work for £27, and if you’re only going to get two people join each time, you know it’s not worth it. I’ve now added them to my sales funnel to buy the masterclass recordings as people join my list.
If you’re looking to sell something under £50, don’t build any of it until you’ve sold it. It sounds backwards, but what if you create it only to find no one buys it? So before you put in the work, look to produce only the first module or skeleton of your product. You then have something to get started and then flesh it out once you know it will sell.
If nobody buys, you’ve then only wasted some of your time and energy. So start with just one masterclass and see what happens. See how many people buy on your list and check you’re selling the things that people want to buy.
Because passive income is usually low priced, you need to think about how many you need to sell to make it worthwhile for you. But also, what is your longer-term goal? If you’re creating a course, you want to sell it again in 6, 12 and 24 months later. You don’t want to keep recreating new stuff; you want a good signature course that you come back to again and again.
You may find it better to focus on getting one big client rather than trying to sell lots of £27 things. Think about what’s the easiest way for you to make money. If you’re already working with one to one clients, it might be quicker and easier for you to just get more one-to-one clients at a higher rate, especially if you’re not yet fully booked. Or do you want to get into passive income so you can get more flexibility around the holidays or to take more time off for the school holidays?
You’ve got to think about whether passive income is a strand of your business you want to grow. And know that it’s not something that will happen overnight - it’s also not going to make you a millionaire! The people who are successful at creating and selling passive income have worked hard at it and have spent a lot of time building a large audience beforehand.
You can use my pricing calculator to crunch those numbers. Establish how much time it will take you to create it and how many you’d need to sell to recoup your time and any kind of outsourcing costs. Crunch the numbers before you start, as the results can be pretty shocking.
Listen more to my podcast on passive income and pricing.
Like what you hear? Don’t forget to rate and leave a review to help spread the word!
The Pricing Queen podcast is produced by Decibelle Creative

domain: economics


Bipartisan Policy Center looks for carbon solutions for forests and farms
On Capital Hill lawmakers are building a bipartisan agenda to find carbon solutions for farmers and forests.
Farmers, ranchers, and forest owners are in a unique position when it comes to climate change. According to the Bipartisan Policy Center, the group has launched the Farm and Forest Carbon Solution Initiative. The initiative’s direct, Robert Bonnie, states, “We’re also going to have to think a lot about outreach. Outreach to large and small landowners, and specifically tribes, beginning farmers, minority farmers, and other folks. We’re going to have to think about specific resources to make sure everybody can play here.”
“There’s the price for their commodity and these ecosystem services creating public benefit for every one of us because it’s how those landowners are choosing to manage. Some of that may happen as capitol outlay and that’s why the program through NRCS is critically important... we should want to partner with that to ensure that source of security, reliability will continue to be there,” Karen Ross, the California Secretary of Food and Agriculture, states.
Natural carbon removal by farm and forest lands is emerging at a critical component of legislative efforts to address carbon emissions and its effect on the environment. Dave Tenney, with the National Alliance of Forest Owners, says that each year some 2 billion tress are planted, helping with the natural sequestration of carbon. “We need policies that will set a level playing field, so that everyone can participate... We should be encouraging rather than discoursing participation.”
The BPC is hoping the federal government will step up and provide market incentives to encourage growers’ active participation in lowering their carbon footprint.
For more information click HERE.


Destiny Piano Music carries a selection of music videos that feature relaxing piano music. The channel currently has eight free videos; most are just a couple of minutes long, but one is nearly two hours in length. Subscribers have access to the following additional selections:
- Short Piano Music
- 3 Hours Videos
- 4K Relaxing Piano Music Videos
- Relaxing Music for Sleeping
- Music for Stress Relief
- Music for Studying Concentration
In the titles we previewed, the video consisted closeups of hands playing a piano or keyboard. The videography itself was professionally-done and visually soothing.
-- Information is current as of June 30, 2022
Developer's Channel Description: Destiny Piano Music is #1 channel for relaxation with hundreds of soothing piano melodies. It brings a sense of peace and calm to your body and soul allowing you to unwind! Get in touch with your emotions, express them in a new way and feel happy together with Destiny Piano Music. Enjoy the best classical melodies and beautiful piano arrangements, use Destiny Piano Music as a perfect relaxation aid! Try now at NO cost and enjoy your 7-DAYS FREE trial period! No commitments! No problems!
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An Unexpected Pandemic Side Effect In Peru: A Comeback For TB
In late February 2020, Martin Valencia Garcia was working as a community agent in Independencia, one of the denser districts of Lima, Peru. His job was to help people access tuberculosis diagnosis and treatment with the TB Móvil program, part of a larger effort led by the nonprofit health care organization Partners in Health to drastically reduce TB rates in Lima's at-risk communities. TB, which most commonly affects the lungs, is one of the deadliest infectious diseases in the world, and Peru, according to data from 2017, has the highest rate of drug-resistant TB in the Americas.
While working, Valencia Garcia met a 52-year-old man with a cough and invited him to get a scan at the TB Móvil van visiting his neighborhood, one of two in the city with an X-ray machine and artificial intelligence technology. The man's results indicated he needed further tests and treatment, but not long after, the whole country was on lockdown due to COVID-19. Tuberculosis services were limited, and Valencia Garcia suspects the man got tired of waiting. "He could not do the exams, and since he couldn't do the exams, he couldn't be diagnosed and he couldn't receive treatment," says Valencia Garcia. Many people have experienced the same, he adds. Though he was in charge of the man's case, Valencia Garcia says he lost contact with him in late April. As far as he knows, the man was never diagnosed or treated.
Tuberculosis kills around 1.5 million people a year, making it a top priority for public health organizations. The United Nations aims to end the epidemic of tuberculosis by 2030, but COVID-related disruptions to TB treatments may push that goal out of reach — and end up propagating strains that are resistant to treatment, which also tend to be the deadliest.
"Many people have undetected cases or have stopped coming to receive their treatment" due to the pandemic, says Luz Villa-Castillo, a study coordinator at Cayetano Heredia University in Lima. The resulting lack of diagnostic testing and inconsistent treatment is masking a rising tuberculosis caseload, doctors fear. Patients who have started antibiotics may not have the right medications to continue treatment, which means they "have likely become resistant," Villa-Castillo says, "because they have let a lot of time pass without going to the health center."
COVID-19 has overwhelmed health-care systems and disrupted TB care all over the world. Peru in particular has struggled to secure sufficient personal protective equipment and continue medical services during the pandemic. "Public health systems in most countries have not made adequate adjustments to care for people with TB in the context of COVID," says Carole Mitnick, a professor of global health and social medicine at Harvard Medical School. Unless major changes occur, she adds, "we're going to see the effects of this pandemic for generations."
A three-month lockdown followed by a 10-month restoration period [of TB services] could result in an additional 6.3 million cases and an additional 1.4 million deaths worldwide in the next five years, according to research from the Stop TB Partnership, an international body coordinating the fight against the disease. In light of those dismal projections, some countries are looking for new ways to combat TB. Peru's Ministry of Health and Partners in Health plan to add to the fleet of TB Móvil units, for example, and lean more expansively into the AI-driven diagnostic tools they carry.
Whether such projects will be enough to stave off a flood of TB cases remains to be seen. "We never learn from mistakes," warned Lucica Ditiu, the executive director of the Stop TB Partnership, which works with 1,700 groups focused on eliminating tuberculosis worldwide, in a recent report. Over the past five years, TB has remained one of the deadliest infectious diseases because it wasn't given priority, she continued. "Today, governments face a torturous path, navigating between the imminent disaster of COVID-19 and the long-running plague of TB. But choosing to ignore TB again would erase at least half a decade of hard-earned progress."
How exactly does tuberculosis spread?
Tuberculosis is caused by a bacteria. Like the COVID-19 virus, TB spreads through the air in tiny droplets after someone with an active infection sneezes or coughs; from there, it typically lodges in the lungs and can spread into the kidney, spine, and brain. One in four people are estimated to have tuberculosis worldwide, but in most cases, the bacteria remains dormant with no risk of transmission. The roughly 5 to 10% of cases that become active lead to chronic cough, fatigue, fever and even organ failure.
These active cases are highly infectious. According to the World Health Organization, a single person with an active, untreated TB infection can infect between five and 15 people per year. Over 95% of cases are in lower income countries. People with HIV or otherwise compromised immune systems are at particularly high risk of active infection. If left untreated, almost half of people who are HIV-negative, and nearly all people who are HIV-positive, will die from TB.
Drug-resistant TB cases are on the rise
Chest X-rays are frequently used to identify possible active tuberculosis infections. If the scan shows abnormalities in the lungs, the patient may have damage due to a TB infection. To confirm the infection, health practitioners take a sputum sample — phlegm that the patient coughs up — and analyze it for tuberculosis bacteria. Then, further diagnostic tests reveal if the bacteria is resistant to drugs. Villa-Castillo has seen long delays in the arrival of these diagnostic tests due to the pandemic and explains that the testing equipment is critical "because then you can quickly start the type of treatment specific to the strength of the bacteria."
While tuberculosis is treatable, an increasing number of cases — about 3% of new cases and 18% of existing ones — are drug-resistant. While a combination of drugs kills most TB bacteria after about six months, patients with drug-resistant TB require intensive treatment for up to two years. The longer treatments are more expensive and often toxic. Only about 60% of people with multi-drug resistance and 40% of those with extensive drug-resistance survive.
Even before the COVID-19 pandemic, drug-resistant TB treatment rates were low. In 2018, of the nearly 500,000 new cases, only a third were given an effective treatment. A study of TB in India, Kenya and Ukraine by the Stop TB Partnership estimates that completion rates for second-line treatments — meaning the second attempt after a first drug has failed — for drug-resistant TB will drop as low as 25% in those countries due to COVID-related disruptions. Incomplete or incorrect treatment can make the bacteria even harder to kill as the stronger strains survive and infect more people.
COVID-19 has complicated matters. Due to disruptions in health systems around the world, TB case notification declined by 75 to 80% in India, China, and Pakistan over the summer of 2020. A Stop TB Partnership survey of the top 20 high-burden TB countries in the world found that staff, isolation wards and specialists are frequently being redirected to COVID-19 care; many TB laboratories and research teams have been shut down; and some TB diagnostic supplies and drug shipments have been disrupted.
"It's nothing short of absolutely devastating," says Mitnick. "More and more people are getting sick and fewer people are having access to care."
While some might hope that COVID precautions could reduce TB transmission, Mitnick is skeptical. "Any benefit would be enormously outweighed by the reality that TB, unlike COVID, is transmitted through sustained, long-term contact." Few people wear masks or socially distance at home with their close contacts, so these protections will have little impact, she says.
Research from the London School of Hygiene and Tropical Medicine also predicts an increase in both TB cases and deaths regardless of social distancing in low- and middle-income settings. In the worst-case scenario, they estimate an additional 200,000 TB deaths from China, India and South Africa alone. And research from Imperial College London predicts a 20% increase in deaths in high-burden countries over the next five years due to delayed TB diagnosis and treatment.
While such research rarely takes drug resistance into account, health service decline is likely to have the greatest impact on patients with drug-resistant tuberculosis. These cases require persistent oversight by doctors and long-term medication. Disruptions in drug availability and fear of clinic visits cause erratic TB management, which is a recipe for treatment failure and amplification of drug resistance.
A fleet of vans bring TB tests, treatment to the people
Peru's overall tuberculosis rates have been in steady decline for the past 10 years. During the COVID-19 pandemic, reported TB cases have continued to decrease, but doctors suspect a hidden resurgence in TB, because patients have stopped coming in to the clinic to be diagnosed and treated.
"The amount of TB reported has gone down," says Salmaan Keshavjee, director of the Harvard Medical School Center for Global Health Delivery--Dubai, but "presumably the amount of TB circulating in the communities has not. So that would suggest that there is more untreated TB out there."
Peru's approach in providing patients with mobile care has been successful in detecting and treating TB in other countries, including Pakistan, Nigeria and Zimbabwe. The vans are equipped with X-ray machines, computers enhanced with artificial intelligence to read scans and diagnostic tests for follow-up. The software uses deep learning to detect abnormalities in the chest X-rays and then creates a heat map of suspicious areas in the lungs and provides a score, from 0 to 100, that suggests the likelihood of an infection.
"If the score is very high ... that person has more risk of tuberculosis," so they perform a diagnostic test, says Leonid Lecca, the executive director of Partners in Health in Peru. "If the score is under 60, we consider the X-ray normal."
"It makes it much easier to screen large populations of people," says Keshavjee. Using this AI-enhanced technology helps triage patients, reduce demand on radiologists, and make more efficient use of TB testing supplies. In a comparison between radiologists and AI machines, researchers suggest that the AI-enhanced readings perform as well as human readers, catching 90% of cases.
This technique "will increase the reach, access and efficiency in providing critical services to all those in need, especially now," during the pandemic, states Ditiu of the Stop TB, in a press release.
But artificial intelligence readings have limitations. These systems are not able to provide insight into drug resistance, because the X-rays reveal lung damage regardless of the strength of the bacteria. The cutoff point for TB suspicion also may vary, because X-ray features are dependent on a patient's age, immune status and prior TB exposure. "The threshold for that is different in different populations and that can affect the sensitivity" of the machine, says Amyn Malik, an infectious disease epidemiologist at the Yale Institute for Global Health. Additionally, scanning is limited by COVID physical distancing precautions, so the number of people scanned per day by each truck been cut in half since the pandemic began.
In addition to adding to the fleet of mobile TB units, the government also plans to test patients for COVID from the vans, says Lecca, which could enhance the impact of the TB Móvil project. Lecca hopes the government will implement a household contact tracing system for TB to prevent spread too. The TB Móvil model could facilitate community mapping of TB cases and help distribute medication that protects exposed individuals from developing the disease.
"If we use this opportunity to dramatically increase uptake of preventative therapy for TB," says Mitnick, "that could mitigate a lot of the long-term effects of the pandemic." However, she adds, "no single solution is going to solve all of our problems."
This story originally appeared in Undark, a non-profit, editorially independent digital magazine exploring the intersection of science and society. Robin Blades is a freelance science journalist and a clinical researcher at the University of California, San Francisco.
Copyright 2021 Undark Magazine. To see more, visit .

domain: medical


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|You Save:||$2.01 (25% Off)|
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- Released: March 1, 2008
- Originally Released: 2008
- Label: Sbme Special Mkts.
Rolling Stone - 10/31/02, p.136Ranked # 14 in Rolling Stone's "Women in Rock: The 50 Essential Albums" - "...A kaleidoscopic masterpiece of feminist striving..."
Rolling Stone - 4/13/00, p.1324.5 stars out of 5 - "...an almost mechanical underpinning of robot funk and juke-joint piano janglings....showcasing Patti at her sassiest and most elastic..."
- 1.Lady Marmalade
- 2.Somebody Somewhere
- 3.Are You Lonely?
- 4.It Took A Long Time
- 5.Don't Bring Me Down
- 6.What Can I Do For You?
- 8.Space Children
- 9.All Girl Band
- 10.You Turn Me On
After two commercially unsuccessful albums for Warner Brothers, LaBelle moved to Epic in 1974 to record the brash, deeply funky NIGHTBIRDS. Helmed by famed New Orleans producer, arranger, and hit-maker Allen Toussaint, NIGHTBIRDS mixes sassy New Orleans R&B with hard-driving funk and LaBelle's soulful, often eclectic, take on girl-group dynamics. On the strength of Toussaint's horn-driven arrangements and the album's runaway smash single, "Lady Marmalade" (with its immediately memorable French refrain), NIGHTBIRDS shot up the charts.
The remainder of the album measures up to the standard set by its single, especially on the sly groover "Don't Bring Me Down" and the thumping "Are You Lonely?" Patti LaBelle's agile soprano alternately soars and seeks out gritty corners, while Nona Hendryx and Sarah Dash providing airtight, in-your-face harmonies. The glam-inflected "Space Children" and "Nightbird," a theatrical ballad, may date the album a bit, but that is part of the fun of this classic, good-time funk-fest.
WCBS FM101.1 - Great Ladies of Rock & Roll - The 70s (CD)(5)
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Ultimate Hits of the 70s/80s/90s (3-CD Bundle Pack)
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WCBS FM101.1 - Motown, Soul & Great Rock 'N Roll: Soul (CD)(2)
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Top ranking CD:
- Various Artists Ultimate Jukebox Hits of the 70s, Volume 4 & 5 (2-CD) ~ 99¢ on SALE
- Various Artists Top Hits of the 70s - Absolute Hits (CD) ~ 99¢ on SALE
- Various Artists Absolute Hits - Top Hits of the 60s: 20 Original Hits (CD) ~ 99¢ on SALE
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- Art Blakey Night In Tunisia / Play Lerner And Loewe (2-CD) ~ $1.98 on SALE

domain: entertainment


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Brad Pitt no longer looking for THE LOST CITY OF Z
Yesterday, news broke that Brad Pitt was in negotiations to re-team with The Assassination of Jesse James by the Coward Robert Ford director Andrew Dominik for a new mobster comedy called Cogan's Trade. Of course Pitt had to make room in his schedule to take on the project, so he said goodbye to Paramount Picture's The Lost City of Z.
Pitt will no longer star in the film, and according to Vulture, the reason "was an impasse with Paramount over compensation for Lost City's director James Gray (The Yards, We Own the Night)." It sounds like they just couldn't come to an agreement. Pitt used the opportunity to finally move on and leave the Lost City of Z behind him.
This movie sounds like it's going to be awesome, and I'm sure it will eventually happen once Paramount gets it together. I don't think the studio will have a problem finding another big name actor to replace Pitt in the lead role. It seems like a character that a ton of actors would jump at the chance to play.
For those of you who don't already know, the film is an adaptation of a non-fiction book by New Yorker staff writer David Grann about the quest to find El Dorado. "Pitt was supposed to play Col. Percy Fawcett, who led a 1925 expedition into the wilds of Brazil, only to vanish as inexplicably as the golden Amazonian city he was seeking."
Here's a description of the book:
A grand mystery reaching back centuries. A sensational disappearance that made headlines around the world. A quest for truth that leads to death, madness or disappearance for those who seek to solve it. The Lost City of Z is a blockbuster adventure narrative about what lies beneath the impenetrable jungle canopy of the Amazon.
After stumbling upon a hidden trove of diaries, acclaimed New Yorker writer David Grann set out to solve "the greatest exploration mystery of the twentieth century:" What happened to the British explorer Percy Fawcett and his quest for the Lost City of Z?
In 1925 Fawcett ventured into the Amazon to find an ancient civilization, hoping to make one of the most important discoveries in history. For centuries Europeans believed the world’s largest jungle concealed the glittering kingdom of El Dorado. Thousands had died looking for it, leaving many scientists convinced that the Amazon was truly inimical to humankind. But Fawcett, whose daring expeditions helped inspire Conan Doyle’s The Lost World, had spent years building his scientific case. Captivating the imagination of millions around the globe, Fawcett embarked with his twenty-one-year-old son, determined to prove that this ancient civilization--which he dubbed “Z”--existed. Then he and his expedition vanished.
Fawcett’s fate--and the tantalizing clues he left behind about “Z”--became an obsession for hundreds who followed him into the uncharted wilderness. For decades scientists and adventurers have searched for evidence of Fawcett’s party and the lost City of Z. Countless have perished, been captured by tribes, or gone mad. As David Grann delved ever deeper into the mystery surrounding Fawcett’s quest, and the greater mystery of what lies within the Amazon, he found himself, like the generations who preceded him, being irresistibly drawn into the jungle’s “green hell.” His quest for the truth and his stunning discoveries about Fawcett’s fate and “Z” form the heart of this complex, enthralling narrative.
Doesn't this make you want to go out into the amazon and hunt for the city of El Dorado? Sounds like a great story, and I really want to see this movie get made! Who would you like to see replace Pitt in the part?


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Date of Submission
Bachelor of Architecture
Over the last eight years, millions of Venezuelans have had to get used to living between blackouts and electricity rationing. The causes of the crisis are multiple and complex and differ depending on whom you ask. The government rejects that there are problems in the electrical system and attributes the cuts to alleged sabotage, and the rationing to the drought and excessive demand. Electrical engineers attribute power outages to power generation deficits, on the one hand, and lack of system maintenance, on the other. Because of the situation with the electrical resource, the government shuts down the power for four to six hours daily.
Zulia, a border region in the northwest of the country, is the most affected state by the very serious economic, social, cultural, and environmental rights crisis in Venezuela. For years, its inhabitants have faced adverse conditions ranging from power cuts that last several days and challenges in securing food, medicine, and drinking water, to restrictions on fuel supply and the almost non-existent public transportation service or communication.
This thesis intends to use the architecture of a Sojourn designed as a conductor of a national phenomenon, the Catatumbo Lightning, and harvest the energy of the lightning strikes to later be used as a resource of power to the community, interrupting the problems that blackouts entail. The purpose of this sojourn is to attract tourists who promote the economic development of the community, while, at the same time, encouraging cultural exchange, creating awareness of the area's problems, and living the experience of a natural phenomenon that occurs through the unique geography of the site.

domain: sociology


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July 28, 2020—Creating strong communication practices within your family is an important component of legacy planning, and even more important during challenging times. You may be asking: Why is family communication imperative to family resiliency and what can be done to improve your family’s communication process? Family Legacy Advisor Libby Turner shares some insights on why many families fail to communicate, and some best practices to help you build trust and open channels of discussion within your own family.
Wilmington Trust Emerald Family Office & Advisory is a service mark and refers to wealth planning, family office, specialized transaction, and other services provided by Wilmington Trust, N.A., a member of the M&T family.
The information provided herein is for informational purposes only and is not intended as an offer or solicitation for the sale of any tax, estate planning, or financial recommendation or determination that any tax, estate planning, or investment strategy is suitable for a specific investor. Note that tax, estate planning, and financial strategies require consideration for suitability of the individual, business, or investor, and there is no assurance that any strategy will be successful.
Wilmington Trust is not authorized to and does not provide legal, accounting, or tax advice. Our advice and recommendations provided to you are illustrative only and subject to the opinions and advice of your own attorney, tax advisor, or other professional advisor.
The information in this podcast has been obtained from sources believed to be reliable, but its accuracy and completeness are not guaranteed. The opinions, estimates, and projections constitute the judgment of Wilmington Trust and are subject to change without notice.
Third-party trademarks and brands are the property of their respective owners.

domain: finance


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PONDS BB+ FEMINA STYLE DIVA WEST BRINGS THE MOST PRODIGIOUS STYLE DIVAS FROM WEST INDIA ON ONE STAGE
Held on 30 th September 2016, Ponds BB+ Femina Style Diva West witnessed participation from16 contestants across The West of India
Style hits a new high and style goddesses took a plunge at the grand finale of Ponds BB+ Femina Style Diva-West powered by Sheetal Creations at The Lalit in Mumbai. The glitzy affair took place on 30 th September 2016 in the presence of an eminent jury.
The glamorous event witnessed immense participation across western region of India. The Style sashayed down the ramp with unapologetic élan, before Sasha Sood from Pune was adjudicated as the winner of the grand finale. Ekta Maru and Ashmita Bakshi both from Mumbai were announced as 1 st and 2 nd runners-up respectively.
Ponds BB+ Femina Style Diva West, which was all about bringing your personal style to the ramp, boasted of a stellar jury including style icon Neha Dhupia, , talented actress Soha Ali Khan, noted fashion designer Nikhil Thampi, Sheetal Biyani, a self-made jewelry entrepreneur and Tanya Chaitanya, editor of Femina magazine.
Speaking About Femina Style Diva, Tanya Chaitanya, Editor Femina said, “Femina Style Diva was launched with an aim to reach out to as many talented girls across different regions in India. We truly believe that every individual has their own unique style statement and through this platform, we wish to encourage these individuals by bringing them in front of the world. With yet another successful show of Femina Style Diva West, we hope to continue Femina’s legacy of nurturing and producing the best style divas across the country.”
To raise the entertainment quotient of the evening, Stand-up artist Sapan Verma had members of the audience in splits with his hilarious act, followed by an ear-soothing performance by Singer Jyotica Tangri.
About Femina :
FEMINA was first published in July 1959 and for over 56 years now, Femina, India’s first and largest read women’s English magazine has long been the definitive life and lifestyle guide for progressive woman. It is owned by Worldwide Media, a wholly owned subsidiary of the Times Group. Femina, published fortnightly, features articles on women achievers, relationships, beauty and fashion, travel, cuisine and health and fitness. In recent years, it has extended its reach by launching its language editions – Femina Hindi, Femina Tamil and Femina Bangla. It also publishes Femina Salon and Spa, a magazine targeted at beauty professionals across the country.
About Worldwide Media:
Worldwide Media is a part of the Times Group, one of India’s largest media and entertainment conglomerates, and publishes Filmfare – India’s No 1 entertainment magazine. Femina – India’s largest women’s magazine, BBC TopGear, HELLO!, BBC GoodHomes, GRAZIA, Lonely Planet Magazine India, Home Trends and BBC Knowledge are other exciting titles from Worldwide Media.

domain: artistic


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COLUMBIA — The chairman of the Horry County Council is the latest Republican to announce he’s running for South Carolina’s new 7th congressional district.
Tom Rice plans to announce his candidacy in stops across the district Wednesday. His nine-city tour is scheduled to start in Georgetown and end in Conway. Other stops along the way include Myrtle Beach, Marion, Florence, Darlington, Chesterfield, Bennettsville and Dillon.
The new district was created in the northeastern corner of the state after the 2010 Census showed population gains.
Republicans who have already announced include former Lt. Gov. Andre Bauer, state Rep. Thad Viers, Gary Stephens, and Mande Wilkes. Democrat Parnell Diggs is also running.

domain: geography


More than 100 people applauded local students at Hands4Hope’s fourth annual Youth Recognition Dinner at the El Dorado Hills Community Services District on Aug. 25.
Youth volunteers with Hands4Hope were recognized for collectively dedicating 6,100 hours of community service to those in need in our community over the 2011-12 year. Additionally, several local youth were singled out for going above and beyond in their service and leadership efforts, according to Jennifer Bassett, founder and executive director of Hands4Hope – Youth Making a Difference.
Some of Hands4Hope’s activities over the past year included supporting the Greater Sacramento and El Dorado County homeless communities; community and school drives for toiletries, clothing and blankets, and items to fill care packages for U.S. soldiers; and mentoring at-risk youth in El Dorado County. Hands4Hope youth volunteers made and delivered 3,012 meals and made 75 blankets for homeless individuals and families. They also gathered 1,700 pounds of toiletries, 5,000 articles of warm clothing and blankets, and 10,781 pounds of food donations for those in need, and collected more than $16,000 in cash and gift cards for local food banks and outreach efforts.
“We have so many wonderful youth that volunteer with us and give incredible amounts time to the serving others,” said Bassett. “They are kind and generous with those they serve and with each other and they inspire me and so many others everyday. Because of this selflessness, it is important to make sure they know how special they are to this community and how much they are impacting those they serve.”
Ensuring that the young people in attendance understand their importance, Tammy Thompson, director of the Twin Lakes Food Bank in Folsom and the evening’s guest speaker. told the youth, “I believe it is so important for you to know that what you are doing really matters. You bring hope to our community. You make an impact in someone else’s life and that has a ‘ripple’ effect.”
Hands4Hope Board members at the event included Pam Maxwell from USBank, Oak Ridge Vice Principal Pam Bartlett, Charles Sharp of Blue Shield, Debi Harlow with El Dorado Waste Connections, T Abraham with Marshall Medical Center, Kevin Barri with Wells Fargo, Kimberly Rumph, as well as youth representatives Kirsti Buckendorf and Emily Abraham.
The Youth Board was represented by Emily Abraham, Kirsti Buckendorf, Andrew Bassett, Mackenzie Ramirez, Guneet Gill and Connor Cahill (all from Oak Ridge), along with Julia Phillips from Ponderosa and Jamin Sagay from Jesuit.
Bassett recognized individual youth members for “Director’s Choice” awards, Brayden Kono, 11; Bailee Seo, 14; Claire Snyder, 14; Emily Abraham, 16; and Kirsti Buckendorf, 17, for exceptional service, dedication and leadership within the Hands4Hope organization.
Buckendorf with 251 hours served, Samita Dutta with 153, Andrew Bassett with 126 hours and Emily Abraham with 104 hours received a Platinum Award from H4H for serving 100+ hours as well as also the Presidential Service Award from the office of President Obama, which included a personalized certificate of achievement and a congratulatory letter from the president. Jacob Bassett, 13; Ryan Thoms, 13; Bailee Seo, 14; Claire Snyder, 14; and Destry Fitzpatrick, 14, received a Gold Award from H4H and the Presidential Service Award for serving 50+ hours.
To receive the Presidential Service Award, youth under 14 must have logged 50 or more volunteer hours to be eligible, and youth 15 and older must have logged 100+ hours.
Hands4Hope is a non-profit, non-denominational, youth driven outreach organization based in El Dorado Hills. The organization’s mission is to grow the next generation of socially responsible citizens by engaging youth in community outreach. Hands4Hope is comprised of youth volunteers ranging in age from kindergarten through 12th grade.
For more information visit hands4hopeyouth.org or call Jennifer Bassett at (916) 919-5695.


Evaluation Kit for the MAX9718A, MAX9718B, MAX9718C, and MAX9718D (MAX9718AEVKIT) (MAX9718AEVKIT)
The MAX9718A evaluation kit (EV kit) is a fully assembled and tested circuit board that uses the MAX9718A differential audio amplifier to drive a mono bridge-tied load (BTL) speaker in portable audio applications. Designed to operate from a 2.7VDC to 5.5VDC power supply, the EV kit is capable of delivering 1.1W into an 8Ω load.
The MAX9718A inputs can tolerate a DC offset level of 0.5V through (VCC - 1.2V) from an input source, therefore eliminating the need for input-signal coupling capacitors. The EV kit provides an option to bypass the input-signal coupling capacitors when the DC offset level of the input signals are within the range of 0.5V to (VCC - 1.2V). The MAX9718A EV kit also evaluates the MAX9718B, MAX9718C, and MAX9718D.
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Ускорьте разработку по готовому дизайну


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Free domestic shipping on orders over $250.
The Mae top is a dolman sleevedshirt with elbow length sleeves and a front and back yoke. 100% cotton textile in a soft pink with black motif and softly textured. Slightly cropped fit.
Made sustainably in India by Ace & Jig.
Allovers - Opera
Jane Dress - ribbon candy
Easy Pant- Rib


Canada-wide warrant issued for man known to frequent Durham
Published July 20, 2022 at 11:17 am
A Canada-wide warrant has been issued for a repeat offender who is a suspect in an incident from earlier this month when a Cobourg police officer was dragged by a vehicle.
Gerald Cooper, 52, is known to frequent Durham Region, as well as Cobourg, Peterborough, Brighton, Belleville and Quinte West.
Cooper, 52, who is wanted as a result of a breach of a statutory release, is currently serving a six-year sentence for break and enter, mischief over $5,000, theft over $5,000, and possession of property obtained by crime over $5,000.
He was named as a suspect in the July 6 incident after as a municipal officer was dragged by a vehicle during a traffic stop. The vehicle fled the scene. OPP subsequently arrested two people but a third – believed to be Cooper – fled on foot.
Cooper is described as white, standing five feet six inches, weighing 170 pounds, and having brown hair and brown eyes.
Anyone with information can contact the Provincial R.O.P.E. Squad at 416-808-5900 or 1-866-870-7673 (ROPE), contact Crime Stoppers at 1-800-222-8477 (TIPS), or call 911.


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Herman Leopoldi, composer of the Buchenwald song (“Buchenwaldlied”), August 15, 1888 – June 28, 1959. The camp commandant organized a song competition soon after the camp opened. Leopoldi and his partner Fritz Lohner-Beda wrote the winning entry, although a non-Jewish kapo submitted it to the contest. The camp guards would command prisoners to sing the Buchenwaldlied as a way to cover up the sounds of torture and other acts of cruelty and murder. Some prisoners found meaning in this song as a symbol of resistance. Singing of freedom and the future gave them the opportunity to express their hopes for the demise of their captors.
To listen to a recording of the song, please click here.


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Archived: Fluorine – Synthetic Methods for Selective Introduction into Small Molecule Drugs
Date: 24 April 2019
Time: 15:00 - 16:00 GMT
This FREE to attend webinar was presented by Dr John Studley, Scientific Update and was kindly sponsored by Navin Fluorine International.
The fluorine atom is now a well-established facet in the architecture of small molecule drugs. In addition to effects on a drug molecules intrinsic physiochemical properties it plays an important role in absorption and metabolism, moderates basicity of neighbouring amine functionality and, through unique stereoelectronic effects, can stabilise binding conformations for key protein interactions. This, coupled with advances in synthetic methodology and scale-up technology, has driven a year on year increase in the number of clinical candidates containing fluorine- a small number of which survive the merciless attrition statistics and become medicines.
2018 was a particularly fruitful year for the pharmaceutical industry- with 38 small molecule API’s approved by the FDA. Of these success stories, 17 (45%) contained at least one fluorine atom.
This webinar looked in detail at the synthetic methods used to selectively introduce the fluorine atom(s) into each of these molecules and explored the likely role of the element in the successful transition of these compounds from research to market.


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Are you looking to improve your skin’s texture, tone, and overall health? Do you wonder where you could find treatments to address them that are safe and effective? If so, you should visit a medi spa in Calgary with laser and light treatments as potential options. At Vive Med Spa, we offer various treatments, such as Pearl Laser Resurfacing, Limelight, PICO Genesis, and Laser Genesis in Calgary, to help you achieve your skincare goals. Learn everything you need to know about these treatments here to choose the right one to address your concerns and maintain the best results.
How Laser Treatments Zap Imperfections & Rejuvenate
Laser treatments target specific skin concerns, such as red and brown discoloration, rough texture, and laxity issues like fine lines and skin thinning. These treatments work by using specific and safe laser wavelengths that target the skin cells to promote collagen production and increase cell turnover, which results in a smooth, clear, and bright complexion.
Top Laser Treatments at Our Medi Spa in Calgary
At Vive Med Spa, we offer popular laser treatments like Pearl Laser Resurfacing, PICO Genesis, and Laser Genesis in Calgary. Each of these treatments can address unique skin concerns. For instance:
- Pearl Laser Resurfacing: Are you starting to see the signs of aging? Pearl Laser Resurfacing is excellent for maintaining your youthful complexion. Not only that, it’s brilliant against scarring and sun-damaged skin.
- PICO Genesis: Unique facial flaws can seem difficult to address. Thankfully, PICO Genesis is a versatile treatment that can help reduce the look of unwanted freckles, sun spots, age spots, and even skin conditions like Melasma.
- Laser Genesis: Lastly, Laser Genesis in Calgary targets fine lines, large pores, uneven skin texture, diffuse redness, Rosacea, and scars. After this laser skin treatment, you will have a more even, smoother, and brighter complexion. Ultimately, getting Laser Genesis in Calgary is a rather versatile treatment option.
Illuminating Light-Based Treatments Rejuvenating Power
Light-based treatments like Intense Pulsed Light therapy (IPL) are also safe and effective options for improving skin texture and tone. IPL targets the upper layers of the skin cells using specific wavelengths of light to reduce brown or red discoloration and improve texture and tone. The Limelight Facial IPL is an excellent option for addressing redness, spider veins, brown spots, sun damage, and pigment changes.
Best Post-Care Treatment: Medical Grade Skincare
The most foundational tip we can give is to use medical-grade skincare daily to maintain results. You might wonder: what makes medical-grade products different from your conventional skincare products in-store? Medical-grade products are results-driven formulations that do so much for your skin’s health. It helps balance your skin’s pH levels, promotes collagen renewal, protects your healing cells, prevents further damage, increases skin cell turnover, and keeps your skin hydrated for efficient healing and lasting results.
Post-Care Treatment Tips By a Medi Spa in Calgary
Here are a few tips on how to use medical-grade skin care products and more to ensure you achieve the results you want after laser or light-based treatment:
Tip #1: Use a Gentle Cleanser
After treatment, you don’t want to irritate your skin further with a harsh cleanser. From the advice of your practitioner, use a gentle cleanser in the evening or the next day post-treatment. We recommend the following medical-grade cleansers:
- Vivier Ultra Foaming Cleanser & Vivier Hexam Cleanser
- ZO Skin Health Balancing Cleansing Emulsion Cleanser & Gentle Cleanser
- Alumier Sensi Calm Cleanser & Purifying Gel Cleanser
Tip #2: Apply a Non-Irritating Moisturizer
No matter your skin type, we can’t stress the importance of moisturizing. Post-treatment, you will want to apply a gentle and non-irritating moisturizer to protect, promote healing and keep your skin hydrated. We recommend the following medical-grade moisture cream:
- ZO Skin Health Hydrating, Renewal & Recovery Crèmes
- Alumier Recovery Balm or Hydra Calm
- Vivier Lexxel, DermaV & Ultimage
Tip #3: Use SPF 40 Sunscreen Daily
One of the cardinal rules of skincare is to apply sunscreen. After a light and laser treatment, you must use at least SPF 40 or higher sun protection. Your skin is already sensitive post-laser, so it is important to invest in good physical/mineral sunscreen to protect your skin from harmful UV rays. We recommend the following:
- Vivier Sheer Broad Spectrum SPF 45
- Alumier Sheer Hydration Broad Spectrum SPF 40 & Clear Shield Broad Spectrum SPF 42
- ZO Skin Health Daily Sheer Broad Spectrum SPF 50
Look for the ingredients iron oxide & titanium dioxide in your SPF. Studies show mineral components can block visible light, which traditional chemical sunscreen cannot do.
Tip #4: Applying Antioxidant Vitamin C Serum Daily
The best way to speed up healing and maintain results is by applying an antioxidant Vitamin C Serum daily. Why? It enhances recovery after treatment, protects collagen and further reduces signs of aging. We recommend the following to help:
- Vivier QuintiSerum™, GrezCine Serum & C E Peptides Serum
- Alumier EverActive C&E™ + Peptide Serum & Alumier A.G.E Serum
- ZO Skin Health Illuminating AOX Serum & Daily Power Defense
Tip #5: Start Incorporating Retinol
Many might struggle to figure out how to incorporate retinol into their skincare routine. However, after treatment, it’s important to include retinol since it boosts collagen and promotes cellular renewal to maintain results. Start at a lower dose of retinol and increase slowly over several weeks as your skin becomes accustomed to the increased rate of cellular regeneration. We recommend:
- ZO Wrinkle & Texture Repair
- Alumier Retinol Resurfacing Serum
- Vivier Retinol .5%
Tip #6: Avoid Sun Exposure
Having the right sunscreen after treatment, it’s also important to go the extra mile to ensure your desired results. You should wear a brimmed hat and UVA/UVB protective sunglasses to avoid direct sun exposure on your face and neck.
Tip #7: Clean Makeup
Skin issues can occur from makeup buildup. Naturally, you want to avoid this after treatment. When applying makeup, be mindful of keeping your makeup brushes or sponges clean. We recommend you regularly clean your tools before touching up your makeup after your treatments to avoid possible infection and irritation from bacteria.
Why Following Up at a Medi Spa in Calgary
It’s important to be consistent with your light & laser treatments to maintain your skin investment. As we age, the skin’s ability to regenerate slows down. Whether you’re getting Laser Genesis in Calgary or other light treatment options, maintenance treatments like are needed to achieve long-lasting results. At Vive Med Spa, our goal is to work with you to help you age as slowly and gracefully as possible, and we suggest you meet with our clinicians to plan your maintenance appointments. With our roots in Family Medicine, we’re a client-focused medi spa in Calgary that provides you with the best products in advanced skincare along with individualized treatments tailored to meet your specific needs.
Brighten Up & Light Up at Our Medi Spa in Calgary
The Vive experience is different for every individual, and we’ll help and encourage you along the way, recognizing that your journey does not begin and end with any one treatment. Our medi spa in Calgary is excited and honoured to work alongside you to help you reach your goals. Whether it’s to get Laser Genesis in Calgary to other light treatment options, we’re here to celebrate your success and realize your full potential every step of the way.
Reveal the best version of yourself at Vive Med Spa, the premier medi spa in Calgary! Experience luxury in our boutique setting, offering various top-notch treatments. Choose lip filler & lip injections in Calgary with our selection of the best Botox, Revanesse filler, Nuceiva, & Juvederm in Calgary. Combat stubborn fat with results-driven fat freezing CoolSculpting or Belkrya in Calgary that makes the Belkrya cost in Calgary worth it. Our laser services also provide effective solutions for hair & tattoo removal in Calgary to laser genesis and vein removal in Calgary. Discover Vivierskin, Latisse, ZO Skin Health, & Skin Medica in Calgary with us to help you enhance your beauty. Begin your journey with us today – call 403-237-8428!


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Provider knowledge, comfort with, and training on genetics screening and diagnostic testing assessing educational needs
Journal of Reproductive Medicine
Educational tools; Genetic carrier screening; Genetic counseling; Genetic screening; Genetic testing; Medical education; Practice guide-lines; Predictive genetic testing; Pregnancy; Prenatal diagnosis; Prenatal genetic counseling; Pro-viders
© Journal of Reproductive Medicine®, Inc. OBJECTIVE: To assess provider knowledge, comfort with counseling, formal training, and educational needs regarding prenatal genetic screening and diagnostic testing. STUDY DESIGN: A one-time anonymous online survey distributed to all providers at a major urban Obstetrics and Gynecology department. Descriptive statistics were analyzed, and categorical variables were tested using Fisher’s exact test. RESULTS: A total of 66 (29%) providers responded from varying training backgrounds. Of those, 18.8% of medical doctors, residents, nurse practitioners, and cer-tified midwives reported no formal training, and only 25% of medical doctors reported continuing medical education (CME) classes; 18.8% reported never having received formal training. Prior training was significantly associated with increased comfort in counseling on screening options (p<0.001) and was associated with reporting recommendations in line with published guidelines. Over 50% of providers, and 80% or more of residents, requested educational information on genetics topics. CONCLUSION: There is increasing training in genetics, and the majority of providers are able to counsel patients in line with organizational recommendations. However, the low reported number of CME courses and provider request for more educational information reflect a need for knowledge on genetic testing and screening. Future implementation of an educational intervention and assessing its impact on provider knowledge and comfort should be assessed.
Delgado, A., Schulkin, J., Raina Kaji, S., & Macri, C. (2020). Provider knowledge, comfort with, and training on genetics screening and diagnostic testing assessing educational needs. Journal of Reproductive Medicine, 65 (1). Retrieved from https://hsrc.himmelfarb.gwu.edu/smhs_obgyn_facpubs/672


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Syrian handler paid Hamas cell to attack Israeli cities
June 29, 2018
(Israel Hayom via JNS)—A Hamas plan to carry out terrorist attacks in Israeli cities has been thwarted, the Shin Bet security agency revealed on Sunday.
According to available details, Shin Bet agents, in collaboration with the military and police, uncovered terrorist infrastructure they described as “extraordinary in its size and level of activity” operating in the Nablus area in the West Bank.
According to the Shin Bet, the leader of the 20-member cell was paid $100,000 by a Syrian operative to target major Israeli cities.
The investigation so far has revealed that the cell became operational in October 2017 and remained active until late April, when all 20suspects were arrested.
According to the Shin Bet, most of the suspects are Hamas operatives, and some have previous records that include terrorist activities, especially building bombs.
During their interrogation, the suspects revealed that they were tasked with carrying out a number of known terrorist-attack attempts, including a bombing in Tel Aviv, a suicide attack in Jerusalem, an attack in the Samaria community of Itamar, and several shooting attacks across Judea and Samaria.
The cell also enlisted the help of a Palestinianchemistry teacher to manufacture explosives.
The Shin Bet said these attacks were foiled “at the11th hour.”
Security forces who raided the suspects’ hideouts seized weapons and explosives, and uncovered information leading to other Hamas terrorist cells, according to the Shin Bet.
“The arrests were carried out smoothly. We surprised them where they least expected it in places where they thought they would be safe. It was a complex operation,” a Golani officer who took part in theraid told Israel Hayom.
The Shin Bet identified the cell’s leaders as Mutassem Muhammad Salem, 35, and Fares Kamil Zebidi, 33.
Details of the investigation had been under a gag order that was partially lifted on Sunday, when Salem and Zebidi were indicted in a military court.
Salem is accused of acting on the orders of a Nusra Front operative in Syria. The two communicated via the Telegram messaging application, which allows for encrypted communications.
According to the indictment, the Nusra Front operative offered Salem $100,000 to prepare and detonate an explosive device in Israel, and he agreed.
“Discovering this cell demonstrates Hamas’s efforts to establish terrorist infrastructure in Judea and Samaria, as well as its constant desire to carry out terrorist attacks against Israeli targets in an effort to undermine the relative calm,” the Shin Bet said.
Commented on the arrests Sunday, Israeli Prime Minister Benjamin Netanyahu said “the Shin Bet security agency, IDF and the Israel Police have thwarted a Hamas terrorist cell that sought to carry out horrific attacks in Jerusalem and Tel Aviv, from Nablus in Judea and Samaria.
“Hamas is trying to attack us both from Gaza and from Judea and Samaria,” he said. “This is why we will continue to maintain security control of all areas west of the Jordan River.”

domain: politics


Activities Sports & Athletics What Bike Spokes Do and How They Function Share PINTEREST Email Print Rachel Johnson / Flickr / CC by 2.0 Sports & Athletics Bicycling Maintenance Basics Baseball Billiards Bodybuilding Bowling Boxing Car Racing Cheerleading Extreme Sports Football Golf Gymnastics Ice Hockey Martial Arts Professional Wrestling Skateboarding Skating Paintball Soccer Swimming & Diving Table Tennis Tennis Track & Field Volleyball Other Activities Learn More By David Fiedler David Fiedler David Fiedler is an experienced cyclist and author of "Ride Fit," a guide to cycling for fun and fitness. Learn about our Editorial Process Updated on 02/05/19 The spokes on your bike's wheels are like the busboys at the restaurant. They're quiet and out of the way, and it's pretty much a thankless job. No one ever notices them when everything is working well, but without proper setup and operation, all sorts of trouble will break lose. What Spokes Do The spokes on your bike may look like little more than metal toothpicks that fill space between the axle and wheel but, really, these mighty little dudes have some important jobs: Add strength to your rimTransfer your leg power from the hub to the wheelSupport your weight on the wheel How Spokes Work How do the spokes accomplish these terrific and heroic feats? First, spokes don't push outward, holding the rim at bay, like it might seem. Rather, the rim is evenly pulled inward by the spokes, which are laced through the hub, the center part of the wheel that rotates around the axle. Tension between the hub and rim is applied evenly in all directions, making the assembly extraordinarily strong and also somewhat flexible and resistant to shock. This uniformly applied tension is what supports your weight on the wheels. The other key role of the spokes is transferring the power from your legs to the rim to make the bike go. Enormous force gets applied to the hub of a rear wheel by the chain and gearing when you pedal down hard, and together the spokes carry the power that has gone from your legs to the chain then out to the wheel. This force driving the bike forward is distributed among many spokes so that there is not too much stress on any single spoke. Keeping Rims True Starting at the hub in the center of the wheel, spokes radiate outward to the rim, where they attach to nipples, which are like little nuts that screw onto the spoke ends. Turning the nipple increases or decreases the tension of the spoke and also pulls the rim slightly to the left or right. Wheel builders and bike mechanics must balance this tension so that the rim is perfectly flat, or "true." Rims become warped, or out of true, when the spoke tension is out of balance. This results simply from using the bike, from spokes loosening on their own or from damage to the rim such as when the wheel hits something hard and deforms the rim slightly, throwing off the spoke tension. Straitening—called truing—a wheel is a tricky task that's best left to a mechanic. If your bike has a loose spoke or two, you should tighten it just until it's snug and plan to have the wheel trued soon. Overtightening a single spoke can pull a wheel out of true.


PURE ANALYSER - Multichannel module add-on
This product is download only.
In order to run this add-on module, Pure Analyzer Essential is required.
Up to 16 channels
Sample rates up to 384 KHz
Network support with the SampleGrabber plug-in (Password-protected audio stream encryption)
Extremely efficient OpenGL based graphics rendering engine, capable of up to 120 fps
Independent display and time-code frame rates
Auto-pause controlled by user-defined threshold
Pure Analyzer Essential is required in order to run Pure Analyzer Multichannel.


New UK crime agency will need proper resource to be effective
With the launch of the UK National Crime Agency (NCA), which will target the most serious organised crime, Neil Blundell, partner and head of the fraud and investigations group at Eversheds, said: ’In an age where crime crosses regions and borders, it is fundamentally important to have a crime agency that does the same. If the NCA is properly resourced and has a wide enough remit, then this should be a positive move.’ …
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This act enables the secretary of state to introduce regulations that will allow undertakers to exit the competitive part of the retail market.
For many years, pregnant women who are employees have had the right to take time off work to attend antenatal appointments. That right will now be extended to other expectant parents.
Analysis from The Lawyer
Which firms are cutting it in this era of slimline rosters, and who are the GC new brooms making clean sweeps? The Lawyer can reveal all
A new breed of lawyer is smoothing the path for companies entering emerging or unstable jurisdictions


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College of Education and Human Development
- College of Business and Economics
- College of Education and Human Development
- College of Graduate Studies and Research
- Waldron College of Health and Human Services
- College of Humanities and Behavioral Sciences
- Artis College of Science and Technology
- College of Visual and Performing Arts
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News and Events
CEHD News from University Relations
For the second consecutive year teachers and administrators from William Byrd Middle School have taken sixth grade students to Radford University to experience a college education.
Associate Professor of Biology Jason Davis has been named associate director of Radford University’s Honors Academy.
Radford University Assistant Professor of Nursing Linda Ely will lead a Radford University team implementing a three-year, $187,000 grant to further prepare nurses and counseling students for drug and alcohol abuse prevention efforts.
Katie Lawson, assistant professor of psychological science at Ball State University, will return to her graduate alma mater Oct. 12 to present on gendered occupational segregation.
HHP Associate Professor J.P. Barfield traveled to Buenos Aires in August to train health care professionals to classify athletes with physical disabilities for sports.


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International Congress “Psychology and health promotion in childhood and adolescence”
November 20-23, 2019.
The 1st PPS-INFAD International Congress will be held at the University of Minho and, at the same time, the 27th INFAD International Congress.
The event, dedicated to the theme "Psychology and health promotion in childhood and adolescence", is organized by the Center for Research in Child Studies (CIEC) of the Institute of Education of the University of Minho, Association of Evolutionary and Educational Psychology for Children, Adolescents, Elderly and Disability (INFAD) and School of Health of the Polytechnic Institute of Bragança.
More information at: Congress

domain: psychology


...when we test drove it today there was an issue with the transmission, when the dude did diagnostics it said that the oil temperature in the transmission was -19, which is obviously bullshit, causing it to operate in emergency mode hence the car not really doing much when throttle applied. I called another electric and he said it is most probably a PCM issue...
The tranny temperature sensor is in the TRS (Tranny Range Sensor - inside the transmission, but has external connector for PCM harness). With a little luck, maybe there's a wiring problem between it and the PCM - broken wire, or maybe a poor/corroded connection at the TRS or PCM. I'd say that's more likely than bad sensor in the TRS or bad PCM.
Check that the connectors are fully mated. People have been messing with the wiring, so maybe one connector was not put back completely. There's a connector C107 in the middle of that wiring harness that includes those temperature sensor wires. There are two similar-looking in-line rectangular connectors beside the brake booster. Those connectors are known for causing problems - often caused by corrosion - might just needed to be separated and re-mated. I do believe that C107 is one of those 2 connectors.
You might also disconnect the vehicle ground at the negative jump post for 15 minutes to reset all the computers, and then reconnect. It's a long shot, but sometimes strange problems are fixed by a "system reboot".
You could troubleshoot the wires and connectors using Section 8W in the FSM (any year '02 to '04 would work for this for your car), but the wires between the PCM and TRS for this are violet/pink and dark blue/black - pins 3 and 4 on TRS, and C4 pins 34 and 35 on PCM (schematics and connector pinout diagrams are in FSM section 8W).


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LGD-4033 or Ligandrol, can be an alternative selective androgenic hormone sense organ moduIator (SARM) realized by just Ligand Treatments and as well Ligandrol LGD4033 at present as few as improvement just by Viking Therapeutics. Though the item will have to be mentioned thát because of loosing androgenicity, lean muscle insensibility not to mention on the whole email address particulars are absolutely not mainly because prominent like with thé SARM S-4. Predicament found in dilemma: Within an essential fashionable Spanish investigating, volunteers whom virtually all absorbed dairy which was superior by way of 3 l regarding CLA process meant for half a dozen several years professional a critical increased remove contained in entire body product body fat muscle size swift and additionally washboard tummy circumference when compared to thosé so,who virtually all consumed whole milk that have been ripe utilizing 3 they would involving european olive tree petroleum. This approach tablet at the same time heIps for getting muscles groups and very thin structure for consumers afflicted with muscIe dystrophy or even other muscle dégenerative problems for instance osteoporosis.
Each cell in your informative post shape contains Androgenic receptors attached. Develop secured an individual quantity for yourself concerning lowest an effective 31 days and nights all-around in relation to models, specifically in the event a man or woman might be selecting distinct sarms by way of when. Hence, why’s this may lots of people or simply sporting events individuals desire to work with Sermorelin approximately all kinds of other peptides that have even more substantial 50 percent of a global just as MOD GRF (1-29) or perhaps CJC 1295 by means of DAC? If you are making Cialis (tadaIafil) on a daily basis, the regular gauge is without a doubt 2.now that her afternoon 5 milligram to five mg by means of jaws.
This sarm is normally caIled lgd4033. A good solid clinical check ended up being carried out around the endocrinoIogy component to Birkenstock boston Health Middle dependent this agreement Ligandrol has thé opportunity in promoting low fat muscle mass proportions plus boost the lean muscle stréngth in our overall body. It is advised for you to spéak precisely to individuals who possess put into use LGD-4033 ahead of calculating out in the open serving. Atmosphere amount procedure, diuretics, vasodilators, digitalis, theophyIline, and even anticoagulation counseling are often just about all defined strategies utilised interior of that considerable power over reoccuring cor pulmonale. Most of these steroid drugs not necessarily grant so many around considerable profit margins inside lean muscle substantial still handful of precisely what effective throughout prepared shopping the human body.
Within the body-building gIobe, LGD will be marketed being a side-effect cost-free alterative to assist you to steroid drugs are often, for instance or even testosterone, to generate a muscular body measurement as well as sporting activities efficiency. This is the correct way successful Sárms LGD-4033 happen to be qualified to visit be. The following offers you the perfect rise from energy as well as energy to rehearse with additional level. Several SARMs possess perhaps béen developed particularly for that counseling of these types of locale successes (i.age. regarding civilized prostate gland hypertrophy). The software is not perform they actually improve the capability for acquiring the modern lean muscle, these besides manage your muscular mass largest part just for the latest for a longer time phase for period.
TB 5 for the purpose of a worldwide sequence associated with studies associated with most likely effectiveness for thymosin beta-4 to advertise sort out for pains within surface and your skin, heart and also cornea. SARMS may just be effectiveness presented with associated with researching for you to libido. An essential huge effusion might possibly create or give rise to dyspnea as a result of waned lung sound level, if there is underpinning pulmonary sickness predominately, mediastinal subtly alter towards the contralateral position, and also faltered enlisting and also feature regarding inspiratory muscle group owed a strong grown pectoral cage. Just, that peptide promotés these cell division, specialization, deveIopment, and additionally readiness to grówth, it will help to in increase the numerous tissues around particular parts from the body.
LGD-4033 often is the desire from the SARM universe. This kind of can be due to thé number for chronic, sinopulmonary inféctions.11 Those that have alpha puppy 1-antitrypsin deficit consist of ended up found to be particuIarly be subject to bronchiectasis, just for mystical motives.12 Other sorts of less-common congenital factors include things like key immunodeficiencies, likely to any weakened or possibly nonexistent body’s immune system technique answer major, common illness which normally impact on these lung. 13 Williams-Campbell disorder could moreover customer for you to bronchiectasis. An individual may possibly start out with a good medicinal drug measure for 10 milligram a good time in addition to raise the remedy volume to use as a result of 5 milligrams each and every plan understanding that works utmost nearly 30mh every time.


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Basel, Switzerland. January 23, 2024, 9am CET
BioVersys AG, a multi-asset, clinical stage biopharmaceutical company focusing on research and development of novel antibacterial products for serious life-threatening infections caused by multi-drug resistant (“MDR”) bacteria, announced today that it has established a long-term research collaboration with the prestigious European institute, Helmholtz Centre for Infection Research (HZI) and its site Helmholtz Institute for Pharmaceutical Research Saarland (HIPS).
Antimicrobial resistance (AMR) is a major global health threat with the currently available therapeutics becoming more and more obsolete due to AMR. In 2019, an estimated 1.27 million deaths were directly attributable to bacterial AMR, with an estimated 4.95 million bacterial AMR associated deaths globally.
As part of its continued commitment to develop new and innovative therapeutics for patients suffering with bacterial diseases, BioVersys has initiated a research collaboration with HZI-HIPS, Professor Rolf Müller and collaborators, with the aim of developing new generations of innovative AMR projects for addressing serious life-threatening infections caused by resistant bacteria.
Dr. Sergio Lociuro, Chief Scientific Officer of BioVersys: “It requires persistent commitment and collaboration with world leading experts to stay at the forefront of science. BioVersys has a track record of successful research and development of novel antibacterial programs and strong partnerships with leading academic institutions working on AMR. We are delighted to expand our network of partners to the HZI-HIPS. Together we strengthen our mutual capabilities to identify and develop new therapeutic agents for patients suffering from drug resistant bacterial infections.”
Prof. Rolf Müller, Managing Director of Helmholtz Institute for Pharmaceutical Research Saarland (HIPS): “Our aim is to tackle antimicrobial resistance by developing innovative anti-infectives for human use. To succeed in this endeavour, we need close interactions with partners from the pharmaceutical industry. In BioVersys, we have found a reliable and experienced partner that perfectly complements the expertise at HIPS. Our collaboration agreement paves the way for advancing our most promising approaches and drive development towards clinical application.”
Several projects, that will be in the focus of the collaboration between BioVersys and HIPS, are also addressed and funded by the German Center for Infection Research (DZIF), where Rolf Müller coordinates the research area “Novel Antibiotics”. In November 2023, DZIF awarded 850,000 € in funding to the team of Rolf Müller and collaborators for one of these projects, dealing with the optimization of an advanced lead molecule aiming at the treatment of multi-drug resistant bacterial infections. The interaction with DZIF creates additional synergies, greatly benefiting the collaboration between BioVersys and HIPS. DZIF is a virtual center of over 500 scientists from 35 institutions and enables access to a national network of scientists and clinicians working in infection research, thus streamlining the research and development process for anti-infective compounds and strategies.
Full PR available here


This piece is reproduced from Chortle. It first appeared in January 2011.
Twenty five years ago this month, British television comedy came as close to achieving perfection as it has ever done before or since. Blackadder II (otherwise known as ‘the Elizabethan one’) first appeared on our screens.
Of course, Blackadder itself started in 1983, so we’ve already marked its quarter-century. What need is there to mark the anniversary of its second series?
In my view, Blackadder II is worth celebrating simply because it is a breed apart from either its predecessor or sequels. The first series, set during the Wars of the Roses, was, for the most part, as overblown as it was overbudget. While it undeniably had its moments, the end result, written by Richard Curtis and Rowan Atkinson, was close to being a TV flop. Blackadder II therefore came very close to not being made at all.
A large measure of the success of the second series is undeniably down to the Blackadder himself, Rowan Atkinson. Wisely leaving the writing to Curtis and new partner Ben Elton, Atkinson also abandoned the foppish, Mr Bean-like – and frankly annoying – persona he had hastily adopted for the first series. Very much at ease in a new beard and costume (producer John Lloyd has even suggested the part made Atkinson aware of his own sexuality in a way he hadn’t been before), the new Blackadder was devious and deeply sarcastic.
Whether displaying his skills as one of England’s finest liars (‘Oh my God, Percy! A giant hummingbird is about to eat your hat and cloak!’), attempting to teach Baldrick mathematics (‘For you the Renaissance was something that happened to other people wasn’t it?’) or simply saying ‘Bob’ (apparently said in a way to mask Atkinson’s own slight speech impediment), the performance is a comic masterclass.
Virtually everyone else in the cast is on career best form too. While Tony Robinson arguably overdoes Baldrick’s stupidity in the later series, this time he gets it exactly right. Having been an intelligent character in the first series whose ‘cunning plans’ were genuinely good, in this series, perhaps balanced by Tim McInnery’s equally gormless Lord Percy, his performance is perfect.
And then, there is Queenie. In a career otherwise undistinguished by many comedy roles, Miranda Richardson, then hot after a dramatic turn in Mike Newell’s Dance With A Stranger, gives the performance of her life as the last Tudor monarch, throwing the convention of Elizabeth as a hardened almost masculine leader on its head by portraying her as a spoilt, coquettish but potentially dangerous child.
With a then up-and-coming Stephen Fry as the obsequious Lord Melchett and Patsy Byrne as the barmy udder-fixated Nursie, it really is the cast from heaven. And even this ignores the contribution of guest stars Tom Baker as mad Captain Rum (‘You have a woman’s hand, m’lady!’) or Rik Mayall as the memorably lascivious Lord Flashheart, a character who despite only being in one scene, could potentially have had a series of his own.
Could something as good as Blackadder II be made today? I don’t see why not but it’s hard to imagine that lightning would strike twice. Perhaps it was just tremendous good fortune that it caught so many figures of the ‘alternative’ comedy scene at the peak of their game. Yes, Blackadder the Third and Blackadder Goes Forth are great series too. But neither are quite what Blackadder II is.
And finally, isn’t it about time the reputation of Ben Elton enjoyed something of a reassessment? Currently one of the most hated men in comedy after his overexposure in the Eighties and perceived ‘selling out’ his co-authorship of the three great Blackadder series is often overlooked. But come on! Richard Curtis didn’t write it all himself. And to misquote the series ‘life without Blackadder II would be like a broken pencil. Pointless’.
Read more: Blackadder II: The perfect TV comedy? : Correspondents 2011 : Chortle : The UK Comedy Guide
Reblogged this on Chris Hallam's World View.
As much as I love the second series, I think the third may be slightly better… probably due to the performance from Hugh Laurie as Prince George.
Thanks. Laurie is brilliant and both series are superb. I discuss series 3 here http://bit.ly/2bL3XGE I do slightly prefer II though.


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Coconut Ube Cookie.
This soft and moist Coconut Ube Cookie is to die for. Ube (purple yam) cookie dough rolled in coconut flakes which add a slight crunch.
Ingredients: Butter, all purpose flour, purple yam, coconut flakes, refined cane sugar, white sugar, brown sugar, eggs, baking soda, cornstarch, and salt.
Contain: Dairy, eggs, coconut.


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By Modupe Gbadeyanka
On Thursday, December 29, 2016, Sokoto State Governor, Mr Aminu Tambuwal, presented a budget of N204.3 billion to the state House of Assembly.
Mr Tambuwal informed the lawmakers that the 2017 appropriation bill is focused on sustainable economic development through substantial investment in critical sectors.
To prove this, the education sector got the highest allocation of over N38.43 billion, representing 27.3 percent. This is the second year running the sector is getting the lion share of the budget.
Also, works and transport sectors got N16.2 billion, while water resources and environment gulped N10.7 billion.
In the same vein, health received N7.7 billion while the ministry of housing, lands and survey got N8.2 billion.
In addition, rural and community development got N5.6 billion, solid minerals and natural resources development received N1.7 billion, while the ministry of commerce, industries and tourism got N4 billion.
Business Post learnt that the state dedicated 69 percent of the budget to capital projects, while recurrent expenditure got 31 percent.
Speaking during the presentation of the bill, the Governor said, “We will prioritise effective resources management and seek intervention in areas with high potentialities to create job opportunities, generate income and improve revenue generation.”
He said further that, “We will work to strengthen capacity building of scheduled ministries to ensure they perform better in their tasks.
“Of great importance to us will be the promotion of partnership with the private sector in areas of strategic importance to our development objective.
“We will promote value chain through agro-processing and diversification by way of giving incentives to farmers and producers.
“We will also create backward and forward linkages between and among institutions, partners and other stakeholders to accelerate economic growth,” he said.
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The association between MD and breast cancer has been investigated in more than 50 studies over the last three decades. These studies have varied in their approaches to the measurement of MD (reviewed in Table ), study designs, and populations. The majority (n
= 42) of these studies were recently reviewed [3
] and incorporated into a meta-analysis. They illustrate a high prevalence of increased density in the general population, whether estimated by percentage density (26% to 32% of women had 50% or more), parenchymal pattern (21% to 55% of women had the P2 or DY pattern), or Breast Imaging Reporting and Data System (BI-RADS) density (31% to 43% had a BI-RADS of 3 or 4) (Table ). Also, the results show that there exists a strong dose-response association between MD and breast cancer regardless of the type of assessment (quantitative or qualitative), the population (symptomatic or asymptomatic), or whether the density assessment was made on a negative mammogram years prior to the cancer diagnosis (incidence studies) or on the contralateral mammogram at the time of the breast cancer diagnosis (prevalence studies) (Table ). However, the strongest overall associations are seen among the quantitative percentage density phenotype estimated subjectively by a radiologist or using semi-objective methods (thresholding and the planimetry or tracing methods) [8
]. Other aspects of the mammogram which have been less frequently examined with risk include the absolute area of density [4
], types of densities (nodular versus homogeneous) [15
], and computer-automated measures of characteristics of the underlying mammogram image or pixel distribution [3
]. To date, these have not consistently shown stronger estimates with breast cancer than the quantitative MD measure [3
]. That density assessed at a variety of institutions with mammograms over differing time periods showed highly consistent results illustrates that the MD and breast cancer association is not greatly influenced by mammogram quality, estimation method, or year the mammogram was performed.
Classifications of mammographic density
MD is correlated with several breast cancer risk factors; the strongest associations are seen with body mass index (BMI) and age [4
]. Importantly, though, MD is an independent risk factor for breast cancer, illustrated in the majority of studies by its robust association with breast cancer after adjustment for these and other risk factors for breast cancer [4
]. In fact, recent studies of percentage MD and breast cancer illustrated that failure to adjust for BMI resulted in underestimation of the effect of MD on risk [17
]. Thus, the adjustments for BMI and age are important for accurately estimating the risk associated with MD.
Modification of association by risk factors and ethnicity
Few studies have examined potential modifying effects of risk factors on the MD and breast cancer association. Hormone replacement therapy (HRT), especially combination therapy, consistently shows a strong positive association with MD [19
] and should be considered in analyses of MD with risk, but studies have not seen a modification of the MD and risk association by HRT use [18
]. A stronger association of MD and risk has been seen among women with breast cancer in a first-degree relative [21
]; but among carriers with a BRCA1
mutation, relative risks were similar to those of non-carriers [25
]. The suggestion of stronger associations among women with high BMI [20
] has been reported, as well as findings that the higher risk associated with low parity is stronger among women with high MD [20
]. No difference of association has been seen by alcohol use [27
]. To date, there is little consistent evidence that the risk associated with MD varies according to other risk factors for breast cancer.
The MD and breast cancer association is not limited to older or younger women of mammogram age. But there is currently no consensus as to whether the association is stronger among one age or menopausal group. Some studies [4
] observed stronger risk estimates among postmenopausal women (or those over age 50), whereas others [6
] found stronger associations in younger or premenopausal women or neither group [30
]. The recent meta-analysis suggested stronger relative risks at older ages that were limited to the 25% to 49% category (versus less than 5%) but no consistent increase across all categories [3
]. Importantly, a larger proportion of premenopausal women have dense breasts (greater than 50% dense), with estimates of 37% among premenopausal women compared with 12% among postmenopausal women. Even without significant differences in association by menopausal status, the attributable risk is much higher in younger women (26%) than in older women (7%) [6
]. This underscores the importance of MD for potential risk prediction in younger women.
Unfortunately, due to the nature of this trait's dependence on a mammogram for estimation, the significance of MD in young women below mammogram age is unknown.
In addition, MD has been seen to be associated with increased risk across several ethnic groups. Studies of Caucasians, African-Americans, and Asian-Americans [12
] have all shown increased risk with percentage or area density. However, the magnitude of association has been weaker [14
] or inconsistent in the Asian and Asian-American populations [12
], questioning the importance of this predictor in the Asian population. In fact, some have suggested that absolute area of density is a better measure of breast cancer risk than percentage density in the Asian population due to their distinct physical proportions [33
]. In general, MD assessed as the parenchymal pattern, percentage density, and absolute area of density appears to be a strong risk factor in a number of populations.
More than masking bias
The relationship between MD and breast cancer is thought to be multifactorial, and in early studies, the main explanation was thought to be due to 'masking bias' [34
]. In breasts with extensive MD, cancers may be masked because they have the same x-ray attenuation properties as fibroglandular tissue. At an initial mammogram, then, cancers in dense breasts would often escape detection and could manifest themselves shortly thereafter. Therefore, the sole inclusion of incident cases arising shortly after a negative screening examination would erroneously give the impression of increased breast cancer risk in women with extensive MD. The MD and breast cancer association was expected to disappear with longer follow-up and repeated screening. But two large cohort studies from the 1990s [4
] challenged the 'masking bias' hypothesis, finding increased breast cancer risks for at least 7 to 10 years after a screening examination. This is also confirmed in the latest large-scale studies on MD and breast cancer risk [6
]. Furthermore, although relative risks for breast cancer are higher when studying incident cases diagnosed relatively shortly after a negative examination than when studying prevalent cases, risk is still strong among prevalent cases [36
]. Similarly, although relative risks are higher when studying interval cancers than when studying screen-detected cancers, studies of screen-detected cancers still demonstrate a strong association [6
]. This was recently illustrated in three nested case-control studies by Boyd and colleagues [6
], who found that compared with women with density in less than 10% of the mammogram, women with more than 75% density had an increased risk of breast cancer (odds ratio [OR] = 4.7; 95% confidence interval [CI]: 3.0, 7.4), whether detected by screening (OR = 3.5; 95% CI: 2.0, 6.2) or detected within 12 months of a negative screening examination (OR = 17.8; 95% CI: 4.8, 65.9).
In summary, the MD and breast cancer association is robust irrespective of measurement of MD, strong in magnitude, not explained by masking bias, independent of the influence of other risk factors, and generalizable to several populations, including both premenopausal and postmenopausal women. Due to the high prevalence of increased MD in the population, this risk factor could explain a large proportion of breast cancers as well as provide additional clinical information for breast cancer risk prediction. Translating the estimates of risk corresponding to different levels of MD into a model that could be used as an assessment tool for breast cancer risk prediction is a logical consideration and is explored in the following section.

domain: biology


text:
Ex-presidential candidate Hamdeen Sahabi has called for the annulment of the referendum on Egypt's new constitution following the boycott of judges and the resignation of the newly-appointed Attorney General.
Judges of Egypt's State Council (Administrative Court) decided on Monday not to oversee the second round of the constitutional referendum that is scheduled for December 22.
Meanwhile, Attorney General Judge Talaat Ibrahim resigned from his post on Monday evening after hundreds of general prosecutors staged a sit-in by his office demanding that he steps down.
"The State Council Judges' boycott of the referendum and the resignation of the Attorney General are new victories for the independence of the judiciary... terminate the void referendum immediately," Sabahi, who is a member of the country's main opposition coalition (known as the National Salvation Front), posted on his Twitter account on Tuesday.
The first round of the referendum took place on Saturday, December 15, in 10 provinces while the second round is scheduled for the upcoming Saturday in 17 provinces.
The final results will be officially announced when the second round concludes.


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Cat Health & Care : Symptoms of Mange in Cats
Symptoms of Mange in Cats
Mange in cats is a rare disease in cats, and it is often confused with allergic dermatitis, but it will cause itching and a pulling at the hair. Learn about the tests that veterinarians do to check for the presence of mites with help from a veterinarian in this free video on cat health and mange in cats.
Expert: Carrie Burhenn
Bio: Dr. Carrie Burhenn is a full-time veterinarian who received her degree in veterinary medicine from Oregon State University in 1990.
Filmmaker: Lisa Fenderson .Watch the video about mange in cats.
Mange In Cats Treatment
Sarcoptic Mange Treatment Combo For Mange in Cats.
The Veterinary strength Sarcoptic Mange 2 oz Combo combines the power of veterinary strength products with a gentle, safe, non-toxic mange-combating formula perfect for treating smaller breeds of animals (under 10 pounds) with mild cases of mange.Sarcoptic Mange Combo 2 oz is effective in eliminating Mange.PetsBestRx Sarcoptic Mange Treatment Spray targets and eliminates sarcoptic mange, while Sulfinex Creamprovides additional protection to nourish and heal the skin. The colloid-based Mange Treatment Spray penetrates deeply into your pet’s skin to attack the sarcoptic mange head-on. This provides your pet with soothing relief; great even for sarcoptic mange in smaller animals such as birds, rodents, and reptiles. Give your pet a double dose of protection!
The Mange Combo 2oz is part of our mange treatment, dog mange treatment and cat mange treatment product lines. Mange in cats should be treated. Treat mange now!

domain: pet