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Treatment for schizophrenia has typically involved the prescription of antipsychotic medication since the introduction in the 1950s of first generation antipsychotics such as chlorpromazine and haloperidol. The subsequent development of second generation antipsychotics provided a wider range of drug options including clozapine, risperidone, quetiapine and olanzapine.
Numerous studies have compared the efficacy and safety of both first and second generation antipsychotics. A key meta-analysis from 2013 (blogged about here) has suggested that clozapine is the most effective second generation antipsychotic and quetiapine the least effective (Leucht et al, 2013).
A recent paper (Vanasse et al, 2016) investigated whether observational ‘real-world’ studies can contribute complementary information on the efficacy and safety of antipsychotics. The authors also hoped to address methodological criticisms of previous observational studies (De Hert et al, 2010) by designing a study that included all patients in a defined population who are ‘new-users’ of antipsychotic medication. Their methodology also included participants who are typically excluded from research due to their age and comorbidities.
The authors conducted a retrospective cohort study based in Quebec, Canada using administrative data from:
- Régie de l’assurance maladie du Québec (public health insurance plan)
- Institut de la statistique du Québec (recording the dates and causes of death)
The study cohort included:
- Adults starting at least one antipsychotic drug who hadn’t received medication during the previous six months
- Prior diagnosis of schizophrenia or schizoaffective disorder
- People receiving treatment between January 1998 and December 2005.
The study excluded individuals not covered by a public drug insurance plan and pregnant women.
The drugs administered included olanzapine, risperidone, quetiapine, clozapine, first generation antipsychotics and multiple-antipsychotics.
No differentiation was made between oral and long-lasting injectable, and dosage was not considered until the sensitivity analysis.
Effectiveness was measured by the following primary outcomes:
- Mental health events including suicide, hospitalisation or an emergency department (ED) visit
- Physical health events including death, hospitalisation or ED visit.
The secondary outcomes measured included:
- Antipsychotic discontinuation (considered a sign of inefficiency or intolerability)
- Switching/add-on antipsychotic treatment
- Combination of the above.
In total, 18,869 adults were included in this study and received the following drugs:
|Antipsychotic||% of cohort||Median daily dose|
|First generation antipsychotic||28.5%||–|
Results recorded during the follow-up period included:
- 50.4% of participants experienced a mental health event
- 35.3% were hospitalised for a mental disorder and 45.5% consulted an ED for a mental health disorder
- 55.8% experienced a physical health event
- 19.9% were hospitalised for a non-mental health disorder and 52.3% consulted an ED for a non-mental health disorder
- 67.7% switched/added-on or discontinued their antipsychotic treatment
- 939 participants died during the study (cause of death was recorded as suicide for 114 people).
When compared to first generation antipsychotics, the following risks for mental or physical health events were identified:
- Those using quetiapine or no antipsychotics were at highest risk of experiencing a health event
- Clozapine and olanzapine resulted in slightly fewer health events than first generation antipsychotics
- Risperidone didn’t result in a significantly different number of events compared to first generation antipsychotics
- Clozapine was associated with the smallest risk of discontinuation, and quetiapine the least chance of switching or adding another antipsychotic
- First generation antipsychotics were associated with the highest risk of discontinuation or switching
- Clozapine resulted in fewer events for people aged 35 and under.
The authors concluded that:
The main finding of this study was the poorer performance of quetiapine and a slightly better performance of clozapine regarding effectiveness when compared to first generation antipsychotics. Additionally, not taking any antipsychotics at event time was also associated with an increased risk of health events.
Their confidence in explaining this conclusion was, however, limited:
Despite clear results, we cannot tell whether the poorer performance of quetiapine is due to the product itself, to suboptimal prescription, or to residual bias (e.g. being unable to control for indication bias – the tendency for the arrival of a new drug is to use it in the most severe cases).
Strengths and limitations
This conclusion reflects the problems associated with a retrospective observational study and highlights that factors leading to potential bias could not be considered when the data being analysed in this study was collected. In this instance, the results were likely to be influenced by the quality of the data recorded on the administrative databases (information bias) and the prescription choices made by clinicians.
Similarly, limited information is provided on the severity of the symptoms of schizophrenia and other illnesses experienced by participants. This arguably weakens any correlation between the efficacy and safety of the medication prescribed and the frequency of hospitalisation for mental or physical health events.
While the results reflect those found in previous studies, the authors acknowledge that ‘our results could thus theoretically be partly biased by confounding factors…’
Study strengths noted include the large number of participants, the inclusion of typically underrepresented people with comorbidities, and its ‘new-user’ design.
Only the overall numbers for suicide and death by other causes are provided, and not for individual drugs. The authors argue that the numbers are too small to be significant; however, this information is vital and should have been included.
While it’s difficult to judge the efficacy and safety of antipsychotics using this methodology, the data collated does provide complementary information on the use of these drugs and valuable insight into the lives of people with schizophrenia.
It would be particularly interesting to compare the data on hospitalisations, financial status, substance misuse, suicide, diabetes etc. with the healthy population of Quebec to illustrate the ‘real-world’ impact of schizophrenia.
Vanasse A, Blais L, Courteau J, Cohen AA, Roberge P, Larouche A, Grignon S, Fleury M-J,Lesage A, Demers M-F, Roy M-A, Carrier J-D, Delorme A. Comparative effectiveness and safety of antipsychotic drugs in schizophrenia treatment: a real-world observational study. Acta Psychiatr Scand 2016: 134: 374–384 [PubMed abstract]
Leucht S, Ciprani A, Spineli L, et al. Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatment meta-analysis. Lancet 2013: 382: 951-962 [PubMed abstract]
De Hert M, Correll CU, Cohen D. Do antipsychotic medications reduce or increase mortality in schizophrenia? A critical appraisal of the FIN-11 study. Schizophrenia Research 2010: 117: 68-74 [PubMed abstract]
Vic CC BY 2.0


Our Commitments ?
Understanding our Client’s Vision for Future Business.
What Made Us ?
We transfer our skills to clients’ business with quality efficiency.
Thoughts Delivered ?
We ensured technology with great success results to all.
Programming testing is the way toward assessing and confirming that a product item or application does what it should do. The advantages of testing incorporate forestalling bugs, lessening advancement costs and further developing execution.
There are various sorts of programming tests by Zovian Technologies, each with explicit goals and procedures:
Acknowledgment testing: Verifying whether the entire framework functions as planned. Incorporation testing: Ensuring that product parts or capacities work together.
Unit testing: Validating that every product unit proceeds true to form. A unit is the littlest testable part of an application. Utilitarian testing: Checking capacities by imitating business situations, in light of practical prerequisites. Discovery testing is a typical method to confirm capacities.
Execution testing: Testing how the product performs under various responsibilities. Burden testing, for instance, is utilized to assess execution under genuine burden conditions.
Relapse testing: Checking whether new provisions break or debase usefulness. Mental soundness testing can be utilized to check menus, capacities and orders at the surface level, when there is no an ideal opportunity for a full relapse test.
Stress testing: Testing how much strain the framework can take before it falls flat. Viewed as a kind of non-useful testing.
Convenience testing: Validating how well a client can utilize a framework or web application to do a job.
For each situation, approving base necessities is a basic appraisal. Similarly as significant, exploratory testing helps an analyzer or testing group uncover hard-to-anticipate situations and circumstances that can prompt programming blunders.
Indeed, even a basic application can be dependent upon a huge number and assortment of tests. A test the board plan assists with focusing on which sorts of testing offer the most benefit – given accessible time and assets. Testing viability is improved by running the least number of tests to track down the biggest number of deformities.
Seven testing standards: Software testing
Advancement of programming testing
Programming testing showed up close by the advancement of programming, which had its beginnings soon after the subsequent universal conflict. PC researcher Tom Kilburn is credited with composing the principal piece of programming, which appeared on June 21,1948, at the University of Manchester in England. It performed numerical estimations utilizing machine code guidelines.
Investigating was the principle testing technique at that point and remained so for the following twenty years. By the 1980s, improvement groups looked past separating and fixing programming bugs to testing applications in certifiable settings. It set up for a more extensive perspective on testing, which included a quality confirmation measure that was important for the product advancement life cycle.
“Testing had arrived at a subjectively new level, which prompted the further advancement of approaches, the development of amazing assets for dealing with the testing cycle and test mechanization tools.”
Programming testing has customarily been isolated from the remainder of advancement. It is normal led later in the product advancement life cycle after the item construct or execution stage. An analyzer may just have a little window to test the code – here and there not long before the application goes to showcase. In case abandons are found, there might be brief period for re-coding or retesting. It isn’t extraordinary to deliver programming on schedule, however with bugs and fixes required. Or then again a testing group might fix blunders however miss a delivery date.
Doing test exercises prior in the cycle helps keep the testing exertion at the front line instead of as a reconsideration to improvement. Prior programming tests likewise imply that imperfections are more affordable to determine.
Numerous advancement groups presently utilize a procedure known as persistent testing. It is important for a our approach – where improvement and tasks work together over the whole item life cycle. The point is to speed up programming conveyance while adjusting cost, quality and hazard. With this testing method, groups don’t have to trust that the product will be worked prior to testing begins. They can run tests a whole lot sooner in the cycle to find abandons sooner, when they are simpler to fix.
Why programming testing is significant
Few can contend against the requirement for quality control when creating programming provided by Zovian Technologies. Late conveyance or programming imperfections can harm a brand’s standing — prompting baffled and lost clients. In outrageous cases, a bug or imperfection can corrupt interconnected frameworks or cause genuine glitches.
Consider Nissan reviewing more than 1 million vehicles because of a product imperfection in the airbag sensor identifiers. Or on the other hand a product bug that caused the disappointment of a $1.2 billion military satellite launch.(2) The numbers represent themselves. Programming disappointments in the US cost the economy $1.1 trillion in resources in 2016. Additionally, they affected 4.4 billion customers.
However testing itself costs cash, organizations can save millions every year being developed and support in the event that they have a decent testing procedure and QA measures set up. Early programming testing uncovers issues before an item goes to showcase. The sooner improvement groups get test criticism, the sooner they can resolve issues, for example,
- Design blemishes
- Helpless plan choices
- Invalid or erroneous usefulness
- Security weaknesses
- Versatility issues
At the point when advancement leaves adequate space for testing, it further develops programming dependability and excellent applications are conveyed with not many mistakes. A framework that meets or even surpasses client assumptions prompts conceivably more deals and more prominent piece of the pie.
Key components of viable programming testing
Programming testing follows a typical interaction. Undertakings or steps incorporate characterizing the test climate, creating experiments, composing scripts, investigating test results and submitting imperfection reports.
Testing can be tedious. Manual testing or specially appointed testing might be sufficient for little forms. Notwithstanding, for bigger frameworks, instruments are oftentimes used to mechanize assignments. Robotized testing assists groups with carrying out various situations, test differentiators (like moving parts into a cloud climate), and rapidly get input on what works and what doesn’t.
A decent testing approach includes the application programming interface (API), UI and framework levels. Also, the more tests that are robotized, and run early, the better. A few groups work in-house test mechanization devices. In any case, merchant arrangements offer provisions that can smooth out key test the board errands, for example,
Persistent testing: Project groups test each form as it opens up. This sort of programming testing depends on test robotization that is incorporated with the organization interaction. It empowers programming to be approved in practical test conditions prior simultaneously – further developing plan and decreasing dangers.
Setup the executives: Organizations halfway keep up with test resources and track what programming works to test. Groups access resources like code, prerequisites, plan records, models, test scripts and test outcomes. Great frameworks incorporate client confirmation and review trails to help groups meet consistence prerequisites with negligible managerial exertion.
Design, Development & Deployment of next generation websites and apps
We’re continuing to focus on giving users more transparency and security
At Infinity Core, we constantly adopt new technologies and development
Administration virtualization: Testing conditions may not be accessible, particularly from the get-go in code improvement. Administration virtualization reenacts the administrations and frameworks that are absent or not yet finished, empowering groups to decrease conditions and test sooner. They can reuse, send and change a setup to test various situations without adjusting the first climate.
Imperfection or bug following: Monitoring deserts is critical to both testing and improvement groups for estimating and working on quality. Robotized instruments permit groups to follow surrenders, measure their extension and sway, and uncover related issues.
Measurements and announcing: Reporting and examination empower colleagues to share status, objectives and test outcomes. Progressed instruments coordinate undertaking measurements and present outcomes in a dashboard. Groups rapidly see the general soundness of a project and can screen connections between test, improvement and other undertaking components.


The party is almost over for gas guzzling Americans. Although gasoline is still far cheaper than in most of Europe, at over $2.00 a gallon for regular in much of the U.S., Americans are abandoning their giant SUVs. Several auto industry publications indicate dramatically reduced sales of large SUVs in the United States and an equally dramatic increase in the sale of smaller, more fuel efficient automobiles (including hybrids).
While there are other reasons why scooters and small motorcycles proliferate in Europe, but not the U.S., could the U.S. market see a boost in the sale of these machines? Honda (with the Silver Wing) and Suzuki (with the Burgman 650) have been testing the U.S. waters for scooter acceptance by commuters. We have previously tested the Silver Wing, and will test the Burgman 650 soon. Smaller scooters are also appearing more frequently around town — seemingly accepted more-and-more by Americans for short trips.
Past “gas crises” in the U.S. have not pushed commuters on to two wheels in great numbers, but things change, and seem to change more rapidly lately.


text:
Just Desserts is, top to bottom, filled with songs that are memorably funny, pensive, angry and just bitterly honest.
Recently, on Facebook, one of my friends sent around a link to an article that went along the lines of promoting '80s new wave band members who had aged gracefully. I didn't click on the link, but, if I did, I have to wonder – notwithstanding the fact that one of its key members is deceased – if someone from the early '80s New York skinny tie band the Waitresses would have found a place on that list. You see, having just heard the band's discography – collected on the recent Just Desserts: The Complete Waitresses – I've come to realize that this is a group that has not dated one iota. Sure, the band took the art rock leanings of Devo, added in a dash of Talking Heads world beat along with a few healthy dollops of ska, but listening to the band's output is like getting a fresh breeze through your house. It's really quite astonishing to hear music from about 30 years ago, and, let's face it, glossy '80s synth pop has not really aged all that gracefully, that still works.
Part of the group's charm is lead singer Patty Donahue's spoke-sung vocals, which ooze and drip with a particular sort of irony at times, and you listen to this band's output and have to feel a bit sad as there will never be a true Waitresses reunion: Donahue died in 1996 at the age of 40 from lung cancer. However, and in a move that might cause some feminists to wring their hands in disgrace, while the lyrics of the band ring true of the female experience ... they were written by a guy! That's right, the Waitresses really was the brainchild of guitarist Chris Butler, who had actually founded the band as a concept in his mind back in the days when he was playing in '70s Ohio outfits such as the Numbers Band and Tin Huey. In the liner notes to Just Desserts, which collects the group's two bona-fide albums, 1982's Wasn't Tomorrow Wonderful? and 1983's Bruiseology along with a stop-gap EP and a few odds and ends, Butler notes that he was really trying to write for an older sister. That has led to some to point out that Donahue was really just a character or a front, but that thinking really does a disservice to the band. Sitting down to just write about this group is a daunting and potentially exhausting task, because, if you listen to their material, you realize just how knotty and dense it is musically along with just how rapid-fire and astute the lyrics are, regardless if Donahue was just a poster girl for a male imagination of the feminine mystique or not. Looking back on this group, you realize that The Waitresses were a true experience and were the real deal in a world of glammy manufactured bands.
That last statement might strike some as odd, for the Waitresses were basically a footnote in new wave music history. They only had a handful of near-hits: the caustic "I Know What Boys Like", the holiday-themed "Christmas Wrapping" and the theme song to the short-lived TV sitcom Square Pegs, which was kind of a comedic precursor to the latter Freaks and Geeks and starred Sarah Jessica Parker early on in her career. You have to scratch your head and wonder just how this band didn't have a big hit, but part of the reason could lie squarely on "I Know What Boys Like" with its lyrics, "I make them want me / I like to tease them / They want to touch me / I never let them". Truthfully, every guy probably knows of at least one girl in their life that is similar to the protagonist of this song, and that might have been the problem. Do you want to be reminded of a tease, especially when you can practically hear Donahue sneering during her chorus of "nyah-nyah-nyah-nyah-nyah"s? Still, the song holds up quite well with its buoyant sax and angular guitars, and, to be sure, the remainder of the material from the album that song graces, Wasn't Tomorrow Wonderful?, is quite top notch as well.
There's a real sense of feminine liberation in the songs here: when Donahue sings "It's my car / I'm going to do the driving" on "It's My Car", a song that features a back and forth argument between girlfriend and boyfriend, you feel that it's a real statement of empowerment. Elsewhere, the album features the growing pains of a young woman coming into her own for the first time: "No Guilt" boasts the memorable and oft-quoted line, "The 31st is when I pay the phone bill / I told them I didn't even know anybody in Toronto!" But it's the music that's just as equally compelling: "Heat Night" features a rollicking guitar line that rises from the murk of a series of herky-jerky stop-starts mid-song, elevating the piece from beyond pop into art. And there's a great chorus fake-out on "Bread and Butter", which actually comes from the later-in-1982 EP I Could Rule the World If I Could Only Get the Parts that's tacked on to the first disc of this two-CD set. Similarly, the Square Pegs theme is acutely emblematic of the high-school experience from a geeky girl's point-of-view ("I'd be cuter without gum in my braces"). Practically everything from this era of the band is excellent.
The second disc of this collection is where things get slightly dicier, but only just slightly. It largely encompasses the thematically darker album Bruiseology, but the record as a whole marks one of a band that was slowly starting to fall apart. Butler was having trouble finishing up some of the songs on deadline, considering that the outfit only had big-name producer Hugh Padgham (XTC, The Police) for a limited time, notwithstanding the fact that Butler more or less admits in the liner notes that he may have had a substance abuse problem with a particular white powder, and Donahue actually left the band before the recording sessions were even completed, seemingly cracking under the pressure. Her absence is particularly notable in the record's second half as there's a quasi-filler instrumental "Pleasure" (that's actually not too shabby, though) which is followed by the song "Spin" that features a completely different female vocalist, which is about the point where you wind up starting to miss Donahue's jaded take on the lyrics. Still, Bruiseology winds up being a whole whack better than its troubled genesis would lead you to believe. "Thinking About Sex Again" and the title track literally stick into your head the very first time you hear both, and "Make the Weather" is an equally agreeable stab of pop rock. Again, you have to wonder why this band wasn't bigger than they were, but, alas, thems are the breaks.
If there's anything less than appealing about these discs, it is that they are perhaps too complete. The instrumental B-side "Hangover 1/1/83" is a dud, and the disc features a two remixes of "Bread and Butter" culled from a promotional single, which is perhaps two times too many for the appearance of the song, given that the remixes only vary from the original slightly in most respects. Still, Just Desserts is a more than welcome album that will hopefully allow people too young to appreciate the group during their original go-around to discover a great band that sounds, in many respects, even more urgent and of the times it did back in its heyday. While the Waitresses might be known for being sort of one or two hit wonders, or even something of a novelty act based on that material, Just Desserts shows that there was more gas in the tank than those familiar tunes would suggest. Just Desserts is, top to bottom, filled with songs that are memorably funny, pensive, angry and just bitterly honest. If anything, perhaps this collection might allow for a rewriting of history, and allow for a reappraisal of this wonderful group. There's a lot to take in with the material of the Waitresses, and I'm even wondering how I got through writing about them given how many sheer ideas are packed into the roughly two hours of this compilation, and that's what makes Just Desserts so ultimately necessary. If you thought new wave was a stodgy genre, run, don't walk, to your nearest record store (or click over to your favourite online retailer) and pick this set up.

domain: entertainment


text:
Jeff Davis Hospital is now offering our patients easy and private access to their medical information online, so you can view your personal health record whenever and wherever you have access to the internet!
You can gain access to the patient portal by providing Jeff Davis Hospital your personal email address at registration.
Once your account is registered, you will be able to securely login with your name and password to gain access to your personal health record fast and conveniently.
Click the link below to be taken directly to the Patient Portal.
Jeff Davis Hospital encourages you to periodically review your medical information available through this portal. Not only will this provide you the opportunity to access useful information about your current health conditions and/or test results, but it will also enable you to verify the information in your record.
Medical Identity Theft is a serious issue. Issues such as unemployment, loss of insurance benefits, the opioid epidemic, and other social factors have driven an increase in such theft. A thief may use your name or health insurance numbers to see a doctor, get prescription drugs, file claims with your insurance provider, or get other care. If the thief's health information is mixed with yours, your treatment, insurance and payment records, and credit report may be affected.
As you routinely review your records, if you see signs of medical identity theft, most notably documentation for care you did not receive, please notify the Jeff Davis Hospital HIPAA Privacy Officer immediately by calling 912-699-6218 Then, visit IdentityTheft.gov to report and recover from identity theft.
Note: Other signs of medical identity theft include:
• A bill for medical services you didn't receive
• A call from a debt collector about a medical debt you
• Medical collection notices on your credit report that you
• A notice from your health plan saying you reached your
• A denial of insurance because your medical records show a
condition you don't have.
If any of these circumstances happen to you, please notify the HIPAA Privacy Officer.

domain: medical


These portable, lightweight, and versatile sealers can be used anywhere. They are ideal for sealing those hard to seal or irregular packages. If you are unsure about which sealer works best for your application, please contact us. Portable sealers are available in clam shell sealers, direct heat sealers, hand wheel sealers, impulse clamp sealers, produce bag sealers, heat wand sealers and I-bar sealers.
Call us today at 559-539-3076 or shoot us an email at [email protected] google-site-verification: google635c0d47cc693305.html


text:
Something worried Babcock. One could see that from the impatient gesture
with which he turned away from the ferry window on learning he had half an
hour to wait. He paced the slip with hands deep in his pockets, his head on his
chest. Every now and then he stopped, snapped open his watch and shut it
again quickly, as if to hurry the lagging minutes.
For the first time in years Tom Grogan, who had always unloaded his boats,
had failed him. A scow loaded with stone for the sea-wall that Babcock was
building for the Lighthouse Department had lain three days at the government
dock without a bucket having been swung across her decks. His foreman had
just reported ...

domain: literature


text:
Everyone dreams of visiting heavenly places that are well-known in the rest of the world as destinations touched by a divine hand. Well, the natural beauty capable of taking their breath away is not located on the other side of the world, but in the middle of the Pacific Ocean, and it is called Easter Island.
Known as the “navel of the world”, Easter Island combines beautiful beaches with inactive volcanoes, as well as the mystical presence of millenary stone statues scattered around the island: the moai. There are more than 800 stone statues buried in the island or located along the coast facing the sea. Some of them have hats and defined torsos, and one of them (only one) has painted eyes.
The island’s charm is all about these statues made of stone, which appear throughout the territory. Researchers are unable to determine who ordered their construction, with what purpose or how they managed to reach the coast of Rapa Nui. The mystery and the beauty of the landscape around the moai makes Easter Island a must for any traveler who calls themselves one.
Places to Visit
Easter Island is formed by volcanoes that emerge from the seabed and shape Rapa Nui as a triangle. The island is conformed by 166 km of green mountains, beaches, sacred sites and places to walk around, all below the blue sky of the South Pacific.
It is easy to get to the island, since all the airlines have flights that go there, although some stop over in Santiago de Chile and then continue their trip until they reach Rapa Nui. Nonetheless, the island’s main activity is tourism, so access is available throughout the year.
Once in the island, the options multiply. The hotel and gastronomic infrastructure is varied and of excellent quality. There are international restaurants and, of course, all of them offer delicious typical dishes made with the best fish of the Pacific and vegetables grown in the island. There are also hotels and guesthouses, camping areas and other places to sleep that offer comfortable and safe facilities surrounded by native vegetation.
Once established in the island, it is time to explore it. Easter Island is not very big, so it is easy to get by on foot or by car. There are places where you can rent cars, jeeps and horses, and there are also tour guides to visit sacred places and all the interesting corners of the island.
The main attraction is the moai. These stone structures can be seen in all Rapa Nui territory, but the most important place is the Ahu, where seven moai can be seen on the coast, facing the sea. It is a sacred place, so it is recommended to enter carefully and with respect and not to talk. The moai are millenary structures, and as such, they are fragile and demand extreme care. Another important place is Anakena, the most famous beach in Easter Island. It is a place of unmatched beauty, with turquoise, warm, still waters, white sand and an ideal temperature for sunbathing and resting. It is located on the northern side of the island, near Hanga Roa (the capital), and it is possible to surf.
The island also has hidden treasures. One of them is a beach beyond the area of Ahu Vaihu that doesn‘t even have a name and it is much bigger than Anakena. This beach has enormous cliffs and it is recommended to get there on foot.
Under the surface, Easter Island offers a unique landscape. Away from the beaches and the South Pacific wind, the tourist can visit the caves near Ana Kakenga. To enter the land and discover its mysteries through a tunel of naturally interconnected caves is simply a movie-like activity, and it can be done in Easter Island, the navel of the world.
Easter Island was one of the 20 world destinations in the race to become one of the new wonders of the world. Considering that the pyramids of Egypt are the only attraction of the ancient wonders that still stands, the organization New Open World Foundation held a contest at the end 2008 for the public to choose seven new destinations. In the end, Easter Island was not chosen among the new wonders, but to be considered among the 20 is a real honor.Francisco Lira

domain: travel


text:
Author Registration for MobiWac 2018 is now available!
This page contains the registration information for authors and participants of the MobiWac 2018 Symposium.
Please read the instructions below.
Note: author registration is intended as the registration performed by at least one author of accepted papers (presenting the paper at the corresponding event). This registration must be performed within September 5th, 2018 by at least one author, and it is mandatory for having the paper included in the proceedings. Additional authors and audience can use the Non-Author registration .Observe that, this year, one registration covers only one paper. If you have have more than one paper with MobiWac and with any other symposium or MSWiM, you must make another registration in the respective co-located venue.
Instructions for the Registration
- Choose the event in which the registration will be performed (main conference, symposia, or Non-author);
- Select options: additional pages (One Page or Two Pages), additional banquet, and additional proceedings;
- Select payment method;
- Enter your ACM paper ID when prompted at the end of your registration.
Note that a valid ACM Membership number is required for "ACM Member" fees!

domain: library


The President continued his attacks on the media Thursday during a briefing on the COVID-19 pandemic, calling CNN fake news, referring, as he often does, to MSNBC as MSDNC, and saying exiting NBC News president Andy Lack was "a hack. "He was asked by a reporter how Fox News had affected his thinking about the pandemic. The President said he watched Fox but that it had not affected him more than any other outlet, though they were "more honorable than some. " He suggested that he didn't think much of most of those others. Trump said NBC was "dishonest news," which was why they "fired Andy Lack. "NBC announced last week that Lack was exiting as part of a management restructuring.
Read more at:


text:
Chinese cooking, like most of Asia, focuses first on a starch like rice or noodles, then adds an accompaniment of meat or seafood, rather than meat first, starch and vegetables second, as found in European-influenced cuisines. Recipes in China are as diverse as the language, with its 80,000 characters, and Chinese immigrants have brought this complex culinary heritage to almost every region of the world.
Heat peanut oil in a small saucepan. Add sesame oil and warm for a minute. Stir in chopped peppers and ground cayenne. Stir well and let stand for 1 hour. Strain and pour into a jar. Store in the refrigerator.
from Kate's Global Kitchen:
China on Wikipedia
Hong Kong on Global Gourmet's Destinations
More country Destinations
This page modified January 2007
Copyright © 1994-2017,

domain: food


text:
One thing I love and look forward to every summer is doing some kind of race. Training for a triathlon, 1/2 marathon or any fun race, is a great way to keep in shape and it gives me a goal to work towards. This summer I was able to convince three of my good friends to attempt their first triathlon with me (maybe after a little wine). The Outdoor Divas Triathlon is an all women's sprint Tri, which is great for first timers and for experienced people alike.
When trying to decide what to make for dinner the night prior, I was looking for something light but filling that would give us energy for our race. This lasagna was the perfect fit! The recipe calls for the best of summer's bounty, like summer squash and tomatoes, and the best part is you never have to turn on the oven. I did add an little more cheese than the recipe called for because lets be honest, I LOVE cheese :) The Lasagna is very easy to prepare prior to guests arriving or you can quickly assemble it right before serving. I served this along with some crusty bread and it was the perfect pre-race meal. Everyone did amazing and we had a great time. Congrats ladies!!! Who is up for round 2??
1/2-1 cup ricotta cheese
1/2 cup mozzarella - Parmesan cheese blend
3 tablespoons plus 2 teaspoons extra-virgin olive oil
8 lasagna noodles, broken in half crosswise
1 garlic clove, minced
2 pints grape tomatoes, halved
2 medium zucchini, thinly sliced
2 tablespoons torn fresh basil leaves
1. In a small bowl combine ricotta, cheese mixture and 2 teaspoons oil; season with salt and pepper. In a large pot of boiling salted water, cook noodles according to instructions.
2. In a large skillet, heat 2 tablespoons olive oil over medium-high. Add garlic and tomatoes, stirring until beginning to soften ( 3 min). Season with salt and pepper. Transfer tomatoes to a bowl. Add remaining 1 tablespoon oil and the zucchini to skillet; season with salt and pepper. Cooking until zucchini are tender (5 min). Transfer to a bowl and mix in basil.
3. Divide 1/3 of the tomatoes among four plates; top each with a noodle half and small spoonfuls of ricotta, zucchini and more tomatoes. Repeat with remaining noodles and tomatoes. Garnish with additional basil and serve.


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The constant challenges of an everyday vegetable gardener and dealing with all the aspects of planting as an amateur.
It is an awareness that helps to achieve Garden perfection.
Thursday, July 14, 2011
Basil going wild
If you love Pesto, grow your own basil and look at some great sites (blogs) with great recipes. It is so easy to make pesto at home. After reviewing a blog called " Vegetarian Food Quest", I made some of my own and it was excellent on many different dishes, including fish, burgers, pasta etc... Thanks to that blogger.
What really caught my attention was the price I noticed in the store for the same Pesto that I can now make at home with my own basil.. It is so simple and so cheap to. Basil grows and just seems to thrive like wild fire.
You have to give this a try.


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The bodies of five British servicemen killed in a helicopter crash in Afghanistan will be repatriated to the UK today.
Captain Thomas Clarke, Warrant Officer Spencer Faulkner and Corporal James Walters, all of the Army Air Corps (AAC), were serving as the aircraft's three-man team when they died.
They lost their lives together with Flight Lieutenant Rakesh Chauhan of the Royal Air Force and Lance Corporal Oliver Thomas of the Intelligence Corps, who were believed to have been passengers on the flight
The Ministry of Defence (MoD) has denied claims by the Taliban that insurgents shot the helicopter down, with initial investigations indicating a "tragic accident" rather than enemy action as the cause of the crash.
More top news
The Air Accidents Investigation Branch has been called in after two people were killed in a light aircraft crash in Oxfordshire.
Philippa has Sunday's weather for the east
Philippa has Sunday's weather for the west

domain: news


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The Cape Hatteras National Seashore (CHNS) announced several recent updates and news items related to recreational activities and seashore conditions on Hatteras and Ocracoke Islands.
News items and events related to the National Seashore for the week of March 3 include the following:
- On the morning of March 1, U.S. Coast Guard Station Oregon Inlet responded to a grounded fishing vessel, located between Oregon Inlet and ORV Ramp 4 off of Bodie Island. The crew of the 72-foot scallop boat were safely removed by an air crew from U.S. Coast Guard Air Station Elizabeth City. Until the vessel is towed away, it can be easily spotted from the beach, the Basnight Bridge, and N.C. Highway 12 near the Oregon Inlet Campground and Oregon Inlet Fishing Center.
- Tideland Electric Membership Corporation (EMC) completed the installation of underground cable along Pole Road yesterday. The installation of the cable was part of a project to improve the reliability of electric service to Ocracoke Island. Work is now underway to terminate and prepare the cable for splicing. If all goes as planned, the overhead power line and poles will be removed at the end of the month.
- The Seashore will celebrate the 150th anniversary of the Cape Hatteras Lighthouse at a special event this December 16, 2020. More details to follow.
- Beach visitors are encouraged to sign up for beach safety text messages by texting “Join OBXBeachConditions” to 30890. Visit Love the Beach, Respect the Ocean for important beach and ocean safety information.
- For current beach access information, go to: http://go.nps.gov/beachaccess.
Community Discussion – Hatteras Island
- Date: March 10 from 6 p.m. to 7 p.m.
- Location: Fessenden Center Annex, 47017 Buxton Back Road, Buxton
- Description: Superintendent Hallac invites the public to visit with staff and watch a presentation on visitation patterns and park activities during the past season.

domain: geography


Touche Amore singer’s other band Hesitation Wounds announce debut LP, share “Teeth”
Touche Amore haven't released an album since 2013's great Is Survived By, but vocalist Jeremy Bolm is now set to release the first full length with his other band Hesitation Wounds. It follows their 2013 self-titled debut EP. If you're not familiar, the band has a pretty impressive lineup: The Hope Conspiracy guitarist Neeraj Kane, former Trap Them bassist Stephen "Scuba" LaCour, and former Against Me! (and current Slipknot) drummer Jay Weinberg. The record's called Awake For Everything, and it's due May 27 via 6131 Records, the same label that put out the first Touche Amore album (Hesitation Wounds' EP was on Jeremy's own Secret Voice label).
The lead single is "Teeth," which is unsurprisingly a ripper and it's also a lot heavier than what Touche were doing on their last album. The metallic edge of Trap Them certainly comes through here, but Jeremy's delivery is cutting as ever. "I'm dying to see what's next, for now I'll just feel the effects," he shouts before the song abruptly cuts off. It's a mic drop that wouldn't have felt out of place on Is Survived By, and it feels equally effective here too. Listen below.


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Python Suit Roberto Cavalli
Pair of trousers in pale yellow python by Roberto Cavalli. Soft python material covered with a thin layer of varnish with shiny bronze reflections. Pants embroidered with silver and gold sequins on the sides. Closure on the trousers at the waist with a golden zipper and the logo of Roberto Cavalli. Fine belt integrated, secured by 3 mini buttons in relief. Jacket with long sleeves, each closed by a golden zipper. Closes on the front with a zipper. Small collar. Inside of the jacket in black viscose labelled tone on tone.
Very good condition.
Size of the jacket: S, shoulders: 40 cm, height 50 cm, height behind 53 cm, sleeves 83.5 cm. Size of the trousers: XS, length: 104 cm.

domain: design


2013-Present All (Brembo Calipers) Fully Sintered
Fully Sintered pads will stop better, last longer and have less fade than the Semi-Sintered pads. If you ride loaded, pull a trailer, ride very aggressively or on a lot of mountain roads we recommend these.
EBC's HH pad is the gold standard and perfect for spirited riding. These high performance sintered pads offer superior stopping power over stock. Sintered pads contain metal which means more friction compared to all organic pads. Stopping is important.
- Long lifetime and ultra high brake effect
- Give perfect braking in any condition, dry or wet
- Manufactured in the USA
- For race use see EPFA or GPFAX pads
- ECE R 90 brake safety approved and TUV tested
If you have any questions about this product email us at LamonsterGarageSales@gmail.com
5 Reviews Hide Reviews Show Reviews
Worked great, went on easy. no squeaking. Better stopping than OEM
Works as expected. Easy to install.
Had the front brakes installed yesterday, perfect fit and they stop so much better than the original brakes.
Also the pads were shipped priority no charge. Received them in just 2 days.
Fast shipping, great communication, nice to order from a person that owns and understands what the Spyder owners need.


Alibi Flickr Photo of the Day
By Tom Nayder [ Mon Dec 6 2010 11:34 AM ]
Entrance to old Mclellan's on Central
This is one of the entrances to the old Mclellan's Five and Dime store on Central Ave in Albuquerque.
Annual Winter Solstice Concert at First United Methodist Church
Bach Violin Concerto in A minor, Cantata BWV 151, a selection of beautiful Renaissance motets of the season and recent music from Irsee Monastery in Bavaria.
The Steve Maase Project • blues, rock at Molly's Bar
A Night in the '40s: Big Band Swing at New Mexico Veterans MemorialMore Recommended Events ››


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Goldfish have always been a recommended pet for both first-time owners and children because: 1) They're plentiful and inexpensive 2) You can win them in the ring toss game at the local fair or carnival and 3) They're very easy to care for. Which reason is not totally true? Well, if you guessed number 3, you're correct!
Goldfish aren't as easy to care for as you've been led to believe, especially if you want them to live a long happy goldfish life (and that's not one year, but up to twenty-five years with proper care!)
Video of the Day
First Off - Get Rid of The Small Fishbowl!
The first item on your agenda should be to get rid of that dreaded small goldfish bowl. A goldfish bowl may be fine for animated goldfish in cartoons, but for the real life goldfish, the bowl is a death sentence! What you need is at least a 10-gallon tank that will meet your goldies' specific requirements.
Keeping goldfish in a small bowl or tank can lead to many health problems and deformities such as a bent spine. Two common, single tail goldies require a tank that is at least 6.5 feet. 'Commons' are best reserved for pond living and your double-tailed 'fancies' will survive nicely in an aquarium (a 20-gallon aquarium per fish is usually recommended.)
Fishbowls = Unhealthy Homes
Did you know that a goldfish's exterior body stops growing when kept in a small area? However, even though the body of the fish will stop growing, its internal organs will keep expanding in size. The spine, fins and eyes will also continue growing and, eventually, this will cause the fish to die as its interiors are squished together and the spine bends into an S-shape. This makes for one very unhappy goldfish. Always keep in mind that those "tiny" goldfish you've won at the fair has the potential of growing into a rather large 15 in. (14cm) or larger fish!
A Social Fish
Goldfish, it may surprise you, not only need a lot of space to grow, but it's ideal for them to have lots of company. They are a very social fish that love interacting with other goldfish. This is another reason why keeping a single goldfish in a small bowl is never a good idea.
Filter or Non-filter?
Make your fish happy with a filtered aquarium basically because of the amount of waste they produce due to their mostly vegetarian diet. Without a filter, your goldfish could die of ammonia poisoning. You can see the signs if the water turns cloudy and you notice their skin turning blackish because their gills, fins and skin are being burned by the ammonia they excrete! This, unsurprisingly, eventually leads to death. Even, in some cases, double filtration is recommended. Remember, your fish will become very unhappy with nitrate spikes and ammonia poisoning, so buy that filter suited for your specific tank.
Now to the Pump!
The lack of surface area in a small bowl can lead to de-oxygenation and your goldfish dying from suffocation. To combat this, you may want to install a pump in your aquarium. If your fish frequently comes up to the surface of the water, you may think he's begging for more food, when in reality your fish is gasping for air. Some recommend an 'air stone' which sometimes doesn't create enough surface movement for the dissolving of new oxygen in the water. This is why a larger tank is important—more surface area! If you still notice your goldfish gasping, install an air stone and if they still gulp, get a pump! If the problem persists, check what you're feeding your fish. Fish flakes can cause bladder problems, but a good quality pellet food may be better and nutritious for goldy.
Unstable water temperature may also make your goldfish unhappy. Even small changes in temperature can stress your goldfish and bring on immune system problems which will make your fish more susceptible to parasites and diseases.
Signs of a Happy Goldfish
So how do you tell if you have a happy goldfish? Being alive and not floating in the water is a good, first sign but you should also be looking for the following:
• Your goldfish should be swimming constantly and not floating, bobbing or sinking.
• They should eat regularly and eliminate their waste frequently. Provide some variety in your fish's diet. Pellets everyday can become boring. Try feeding your goldfish treats like peas, spinach, shrimp or Daphnia.
• The appearance of your goldfish should be shiny. Dull areas on the scales is not a good thing and the same goes for dull looking eyes! A stressed fish needs attention!
• Relationships between tank mates must be closely observed. Don't allow your goldfish to become a victim of other more aggressive fish. You may notice tears in the fin or bite marks. Goldfish, unlike other fish, are best kept in goldfish only tanks rather than in a tank of, lets say, mixed tropicals. A fish less stressed is a definite happy fish!
• Your goldfish is very social so get your goldfish some friends (while avoiding overcrowding of course.) Fish company will make your goldfish happy!
• Goldfish do not have eyelids so you'll make your goldfish happy by not turning the aquarium lights on and off! Try using a dimmer (yes, sorry, something else to buy.) Goldfish also hate loud noises so try not banging or tapping on the tank. A fish less stressed is a definite happy fish!
By Tom Matteo
About the Author
Tom Matteo has been a freelance writer since 1992. He specializes in hardware and software reviews for computers and gaming systems, and occasionally writes about such topics as animal behavior and care. Tom resides in Bethlehem, PA with his wife Tina and his beloved cockapoo, Angel.

domain: pet


Google has purchased the cutting-edge robotics firm which supplies mobile research robots for the Pentagon. The tech giant is keeping secret what it will pro...
Google Buys Scary Military Robot Maker
The Five Most Terrifying Robots in Google's Arsenal
Why Google wants robots
Google's Robot Army: Military or Civilian Purpose?
Google Robots Of The Future Projects
Google's 5 Bets on the Future: Robots and Sensors