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Citric acid is a natural preservative found in many fruits and vegetables. It is also used as a food additive and in cosmetics. Citric acid is safe for dogs when used in the recommended doses. It can be used as a natural remedy for dogs with diarrhea, as a mouthwash, and as a preservative in pet food.
Other PersianUtabe articles introduced you to citric acid, a popular and well-liked substance with numerous applications in a variety of industries, including citric acid in dog food.This natural compound is found in almost all plant and animal tissues and is a substance essential for the conversion of biochemical energy in every cell. Life would be impossible without a citric acid (Kreb's) cycle, which is involved in the production of ATP (the body's vital energy).While some human foods are safe for dogs in moderation, others are quite toxic; for example, high levels of citric acid are toxic to dogs.The important thing to remember is that dogs dislike the taste of citrus, and citric acid is usually present in significant amounts in citrus; too much citric acid can irritate your dog's digestive system, resulting in vomiting and immediate diarrhea.
Citric acid antioxidants in dog food
Antioxidants are substances that aid in the prevention of the oxidation of fats and fat-soluble substances (such as vitamins A and E). When a fat is oxidized, its flavor deteriorates and much of its nutritional value is lost.Loses.
Dog and cat foods, which frequently contain significant amounts of fat, are especially prone to oxidation; canned foods are protected from aeration, but dry foods require antioxidants to be preserved.
The American Food and Drug Administration (AAFCO) guidelines require that the common name of the antioxidant appear on the label, with reference to the fact that it is used as a preservative. There are both natural and artificial ones, all of which work to protect food from oxidation. The most common synthetic antioxidants used in the pet food industry are:
Tocopherols (vitamin E), ascorbic acid (vitamin C), citric acid, and rosemary are common natural antioxidants, as are ethoxyquin, butylated hydroxytoluene (BHT), and butylated hydroxy anisole (BHA).
Citrus fruits contain citric acid, which is beneficial to dogs.
Oranges and mandarins are low in citric acid and are usually safe for your dog until you overdo it, but watch out for citrus fruits as high in mandarins as oranges. Clementine, grapefruit, oranges, and pomelo are other low-citrus foods that are safe for dogs.Although these fruits are low in citrus, they are high in sugar and should be consumed as a snack rather than a main meal.
Follow us to get your questions answered.
Is citric acid in dog food harmful?
Citrus fruits contain citric acid, which can be toxic to dogs in large quantities, causing central nervous system problems and depression.However, most dogs dislike the taste of citrus fruits and avoid them on their own.
Is citric acid harmful to dogs?
Natural preservatives, such as citric acid, vitamin E, and rosemary, are safe because they occur naturally in the world and are used in food.
Is bloating caused by citric acid in dogs?
Dogs fed dry foods containing citric acid that had been moistened before feeding were 32% more likely to experience bloating.
Citric acid in pet food
Citric acid is used in pet foods as a supplement in antioxidant maintenance systems, chelating oxidizing minerals and preventing the formation of free radicals.It is typically used at a few parts per million, and no side effects have been observed even when fed at extremely high doses (up to 1000 times what is used in pet foods).
Many pet foods contain low doses of citric acid, which is used as a beneficial and natural preservative; the small amounts found in these foods have no negative side effects and should not be a cause for concern.A small amount of citrus in animal feed is not harmful, but a large amount is not.
Citric acid is a common additive in pet food that is mostly used in the fat storage system (antioxidant), and nutritionists consider it to be a natural functional compound.
Given the foregoing, we conclude that while citric acid is not moderately harmful in dog food, excessive amounts can cause poisoning and gastrointestinal symptoms.
Last Updated Sept 21, 2021
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Why is citric acid present in dog treats?
Citric acid is a common additive in petfood, mostly used in the fat preservative (antioxidant) system. Food and nutrition experts regard this ingredient as a natural functional compound that, at worst, is harmless to pet health and wellness.a common additive used mostly in the fat preservative (antioxidant) system. Food and nutrition experts consider this ingredient a natural functional compound, which, at its worst, is benign to pet health and wellness.
Can dogs lick citric acid?
Dogs eat a lot of things they shouldn't, and while some human foods are safe in moderation for dogs, others are extremely toxic.High levels of citric acid are toxic to dogs and should be avoided.High levels of citric acid are not suitable for dogs and can even be toxic to them.
Is bloating caused by citric acid in dog food?
Dogs fed dry citric acid-containing foods that were moistened prior to feeding had a 320 percent increased risk of developing bloat..
What foods can cause a dog's stomach to upset?
Human Foods That Are Harmful to Your Dog.
Caffeine and chocolate: It's a well-known fact that chocolate is toxic to dogs.... .
Grapes and Raisins. ... .
Alcohol and uncooked bread dough....
Xylitol. ... .
Onions and Garlic. ... .
Other Foods Harmful to Dogs..

domain: biology


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Despite a still-widespread perception that breast cancer is the greatest threat to women’s lives, heart disease is the No. 1 killer of women. While 1 in 31 American women dies from breast cancer each year, 1 in 3 dies from heart disease. That’s approximately one woman every minute!
Another misperception is that heart disease is a “man’s disease.” Not so. An estimated 44 million American women are affected by cardiovascular diseases, and 90 percent of women have one or more risk factors for heart disease or stroke – yet only 1 in 5 women believe that heart disease is her greatest health threat.
At the Cooper Women’s Heart Program – one of the largest female cardiology groups in the Delaware Valley – we want to change these troubling statistics by empowering women with information about heart disease, especially what they can do to reduce their risks and take charge of their heart health.
“First and foremost, women need to know they are at risk so they can take appropriate preventive steps,” says Joanne K. Mazzarelli, MD, FACC, who is board-certified in cardiovascular disease, and internal medicine.
“Many of these risk factors can be managed by adopting healthy habits,” Dr. Mazzarelli notes. “Sometimes medication to manage blood pressure or cholesterol is appropriate. And sometimes medical or surgical intervention to address obesity or diabetes is indicated.
We offer a spectrum of resources, depending on what risk factors a woman has,” she adds.
“By taking preventive action, you can dramatically reduce your risk of developing certain types of heart disease,” says Dr. Mazzarelli, “And the earlier you take action to keep your heart healthy, the better.”
Making lifestyle changes early may affect your chances of having a heart attack or stroke later in life, adds Kathleen M. Heintz, DO, FACC, board certified in cardiovascular disease.
Resources available through Cooper’s Women’s Heart Program include nationally recognized expertise for treating valve disease, a cardio-oncology program that treats patients with chemotherapy related heart disease which can be seen in breast cancer patients, alternative imaging modalities for women with symptoms that suggest cardiovascular disease but who do not have obvious blockages in their coronary arteries.
Cooper’s Women’s Heart Program has many strengths and the largest team of cardiologists dedicated to women’s heart health right here in South Jersey,” Andrea M. Russo, MD, adds.
Women in Their 20s and 30s
“This is when you need to focus on lifestyle,” says Dr. Mazzarelli. “If you smoke, quit before too much damage is done. If you’re sedentary, get more active. Maintain a healthy weight and make smart dietary choices.”
“This is when you need to focus on lifestyle, weight and exercise” says Dr. Mazzarelli. Smoking, obesity, and a sedentary lifestyle are becoming common among young women and are major risk factors for atherosclerotic heart disease and diabetes. Maintaining a healthy weight and exercising several times a week can substantially reduce the risk of developing atherosclerotic heart disease later in life. Virtually any type of exercise is beneficial, with as little as one hour a week providing benefit to the heart.
Regular exercise, yoga or tai chi, and meditation are good options to help. It’s also important to know that for younger women, the combination of smoking and taking birth control pills increases heart disease risk by 20 percent.
These are a woman’s childbearing years, so her primary physician is often her OB/GYN. But it’s also a good time to establish a relationship with an internist who will begin to monitor other heart-health markers like cholesterol (the American Heart Association recommends you start having your cholesterol checked at age 20 or earlier).
Women in Their 40s and 50s
“Wellness becomes paramount at midlife, and many women at this stage of life need to learn how to take care of themselves better after a lifetime of putting others’ needs first,” says Dr. Heintz.
These are the decades when women start to experience the hormonal shifts and metabolic changes that signal perimenopause and menopause.
“This is when we focus more on risk factor modification,” says Dr. Heintz. “At this stage of life we often start to see weight gain and increases in blood pressure, cholesterol, and blood sugar levels. It’s important to turn these around because it gets even harder as you get older.”
This means taking ownership of these health risks – and it often means taking medication.
“It’s also not too late to adopt what we call ‘primary prevention’ measures like exercising and eating right,” says Dr. Heintz, “along with regular health screenings.”
“Symptoms in women can be very different than in men,” Dr. Heintz says.
“While we’re conditioned to think the classic sign of a heart attack is extreme chest pain, women are more likely to experience shortness of breath, nausea/vomiting, and back or jaw pain. Other symptoms women should be aware of are dizziness, lightheadedness or fainting, pain in the lower chest or upper abdomen, upper back pain, and extreme fatigue.”
Stressors like caring for aging parents can trigger anxiety or depression, which can have an impact on heart health. Mood swings associated with hormonal changes can wreak havoc with your emotional equilibrium. Sleep issues can start to show a link between too-little sleep and increased risk of heart disease.
Women in Their 60s and Beyond
As women transition past menopause – and lose the cardio-protective benefits of estrogen – their incidence of heart disease begins to match that of men. Atrial fibrillation (the most common heart rhythm disorder, which increases stroke risk), atherosclerosis (plaque buildup that clogs the arteries) and high blood pressure become more common.
“You can’t think of yourself as low-risk anymore,” says Andrea Russo, MD, director of Cooper’s Electrophysiology and Arrhythmia Service, who is board-certified in cardiovascular disease and cardiac electrophysiology. “While we still focus on modifying risk through healthy lifestyle choices, regular screenings, and managing any health issues you may have, it’s now more important than ever for women to recognize the symptoms of heart disease and to take them seriously.”
“Women may experience more frequent palpitations than men. Don’t assume any of these symptoms are nothing,” says Dr. Russo, “report it to your doctor and seek medical attention; don’t minimize it.”
“Today we have a powerful arsenal of medications and technologies to treat arrhythmias tailored specifically to women’s needs,” she adds. In fact, one of Dr. Russo’s clinical interests is gender differences in arrhythmia.
To make an appointment with one of our female cardiologists, call 1.800.8.COOPER (1.800.826.6737 ) or to find out more about the Women’s Heart Program at Cooper, visit CooperHealth.org/womensheart.

domain: medical


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States are inconsistent in deciding whether food processing workers, especially meat and poultry plant employees, should get a high priority for the coronavirus vaccine, and it’s frustrating some workers and others.
Some states are putting meat plant workers in the second wave of priority for the vaccines, behind health-care workers. However, others aren’t giving them any priority at all, notwithstanding that 284 meat plant workers have died of COVID, according to the Food & Environment Reporting Network.
The U.S. Centers for Disease Control (CDC) has recommended that food and agriculture workers receive a high priority for the vaccine, even ahead of senior citizens and people with health conditions. However, states are responding inconsistently.
“Unfortunately it’s just been kind of a potluck at the state level,” the president of the North American Meat Institute told Reuters.
In South Dakota, which saw massive COVID outbreaks in meat plants with five deaths, the next wave of shots is going to teachers, funeral home workers and people with underlying health conditions. Meat plant workers there might not get vaccinated until next month. North Carolina’s agricultural commissioner says migrant farmworkers, who are beginning to arrive from Mexico, are not yet eligible for shots. In California’s heavily rural Sacramento County, food plant workers had been designated for the second wave of shots, but found themselves removed from the priority list with no explanation.
Meat processing companies, including Tyson, Cargill and JBS, have been offering employees vaccines on-site, but they can’t deal directly with drug manufacturers; they need to source vaccines from the same places as everyone else.

domain: food


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As summer approaches, Ventura County Animal Services takes in increasing numbers of pets who have been abandoned or let stray through no fault of their own. Adoptable Sunny arrived as an owner surrender in April and quickly proved to be an affectionate girl. Sunny is a darling lionhead bunny who is spayed, litter box trained, and ready for a loving, indoor home where she can enjoy the summer days with her forever family. Ventura County Animal Services – Camarillo location – 600 Aviation Drive Sunny A684009
Hi: I’m Truffle a 1 1/2 year old beautiful Chow X in need of a new home as I’m too energetic for my previous owner. I really need an active person or family who can give me lots of love, attention and exercise. I hope you have a strong arm as I love to play fetch and play with toys. I am people and dog friendly, a little shy but I’m overcoming that the more socialization I get.
I’m in a foster home with a German Shepherd foster brother to play with. If you have room in your home and heart for wonderful me, please stop by to meet me. Canine Adoption and Rescue League C.A.R.L. CARL Adoption Center-call 644-7387 for more information.

domain: pet


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Bought at $84, it crashed to $69 - I said, "OK, well it's hit rock bottom now, just wait for it to go back up to $75 or so and cash out". Since then, $2 or so decline daily. Each time I say to myself, "OK now it's really hit bottom - hold on - maybe buy more - it can only go up from here".
THIS FUCKING STOCK IS RUINING ME ! ! ! AND I'M PISSED ! !
The horror ... The horror. Yes we all know that pain in the pit of our stomachs as we watched this baby plummet. I got in @ 63 and change and watched it go to the 90's and then watched it get crushed back down to this level. Welcome to Wall Street and high tech stocks.
Look seriously at your investing time frame and then decide what to do with TLAB. If you can bear to stick it out and wait a year, I would say hold on. If you can't, then take the loss and move on. My personal feeling is that this company has too much going for it not to recover and move higher. Tellabs is extremely well positioned for the future. This setback is temporary.
or you bought on margin and are afraid of getting squeezed, I think you should probably stop watching the share price for a little while. No offense, but I don't think TLAB was ever worth 84 with or without CIEN, regardless of the fact it beat the estimates. At that point it had a P/E much higher than its projected rate of earnings growth with or without CIEN. However, I think TLAB is worth a solid 65-70 right now, and should snap back to that level as soon as the market gives it a chance. If the merger doesn't go through (long shot at this point), I recommend you sell on the mini-rally that will follow. Otherwise, just realize that, whatever happens short-term, you will be well above 84 where you got in within a year. These guys know what they are doing, just give them a chance.
I held TLAB for 1 year, from 65-90, back down to 59. Just sold last week. I like TLAB, BUT CIEN may cause a short term problem the next quarter. Wall street adage, "when there is one roach, more follow". I am banking on TLAB (because of Cienna) to miss earnings, next quarter or revise estimates down... That should sink TLAB to about 45 hopefully. That will be my entry point. After holding TLAB for one year 65,to 42, to 93, back to 59. I have come to a conclusion. Stick it to them before they stick it to you. Trade the bugger... Life99 hang in their, it is to late to bail out. TLAb is a good company, and WDM is the technology of the future. I can empathize with you, since my one years gain a good 12,000 vanished in 1 week. Regards, Rajesh

domain: finance


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Whether we’re shaving our heads or literally giving the coats off our backs to keep others warm, we take our social responsibility seriously.
From volunteering at soup kitchens, to local food banks, we are proud to do our part to help the community.
Being able to support others through fundraising runs, coaching little league sports, or cleaning up the community empowers us every day.
WVGYBWe've Got your Back
Wireless Vision’s Got Your Back has given back to communities that sustain not only our business, but our local families. Thanks to WVGYB and the dedication of WV volunteers, we have donated
“Wireless Vision has always strived to create a strong sense of family, from top to bottom, and in doing so we have been able to continually grow as a company while giving back to our community”
How it all began…
WV’s Got Your Back started in 2013 and was originally intended to give backpacks to local children in need during back-to-school season. Hence, the “We’ve Got Your Back” slogan. Initially in partnership with the T-Mobile’s Got Your Back program. WV eventually branched out on our own upon gaining a following and brand separate from T-Mobile. That’s when our giveback program evolved into an exclusive WVGYB initiative and successfully grew to become our social responsibility drive that focuses on education, kids, military, and helping our communities.
We want to be known as the company that everyone can count on.
We are incredibly proud to be an organization that truly puts people first. Our leaders have paved the way for us to be a part of the Giveback Movement and we will continue to share our success with the communities we serve.

domain: sociology


text:
A genetic disorder caused by silencing of a gene on the X chromosome, fragile X syndrome affects about one child in 5,000, and is more common and more severe in boys. It often causes mild to moderate intellectual disabilities as well as behavioral and learning challenges.
The gene responsible for fragile X syndrome, the most common inherited form of intellectual disability, was identified more than 25 years ago. Emory genetics chair Stephen Warren played a major role in achieving that milestone. His work led to insights into the molecular details of learning and memory, and nationwide clinical trials — which have a more complicated story.
Treating the molecular basis of a neurodevelopmental disorder, instead of simply addressing symptoms, is a lofty goal – one that remains unfulfilled. Now a new study, supported by the National Institute of Neurological Disorders and Stroke, is reviving a pharmacological strategy that Warren had a hand in developing.
“This is a very well thought out approach to studying changes in language and learning in children who are difficult to test,” says Amy Talboy, medical director of Emory’s Down Syndrome and Fragile X clinics, who is an investigator in the NINDS study. “It could change how we conduct these types of studies in the future.”
Flip the classroom
Working with Warren, Talboy and others at Emory, medical illustrator Michael Konomos has assembled an iBook – available free through Apple iTunes – introducing medical students to the science of fragile X and its history using multimedia. This summer, the iBook won an “Award of Merit” from the Association of Medical Illustrators in the Interactive Textbook category. It contains video interviews with Warren and Talboy, along with animated depictions of how the molecules involved in fragile X syndrome lead to differences in learning and behavior.
“Genetics and neuroscience are often taught to medical students by professors leaning heavily on projected slides in the classroom, giving little insight into the vast molecular world that exists within the human body,” Konomos says. “The iBook was designed to depict basic science in a way that would interest medical students, not only teaching them about the particular subject of Fragile X, but awakening their own interest in engaging in fundamental science research themselves.”
Medical educators Gordon Churchward and Kathryn Garber brought the iBook into the genetics curriculum for first-year students in the fall of 2017, and are planning on using it again this fall. It’s part of an effort to use non-lecture-based (“flipped classroom”) teaching strategies.
“What Michael has put together is an amazing platform for providing information. I think the students found it refreshing,” Garber says. “What stood out to them especially was the material from Amy Talboy. That goes so much farther than a bullet point list of symptoms. She has a lot of experience with individuals with fragile X – and it’s not always so easy to bring them into an intimidating classroom environment.”
Children affected by fragile X syndrome display intellectual disability and delay of milestones such as language. Individual affected childrens’ capacities vary, but fragile X syndrome frequently includes autism-like features, such as impaired social skills, gaze aversion/social anxiety, hyperactivity and repetitive behaviors. The iBook uses artists’ depictions to portray the syndrome’s characteristic head shape and facial features.
In her interview, Talboy outlines how building rapport and working with affected families are important: She says: “We don’t make the child with fragile X the center of attention immediately. If they don’t want to come into the room, we don’t make them… You really have to take quite a bit of time. This is not a 15 minute appointment. It may not even be the first visit.”
A genetic anomaly
In his sections, Warren describes the “Sherman paradox,” named after colleague Stephanie Sherman, who observed that the number of affected males in fragile X families tended to increase generation by generation. For leaders in the field at the time, this well-documented phenomenon was confounding, he says.
The anomaly was explained by an expanded triplet repeat (CGG). With each generation, the number of repeats tends to rise. So if a mother has a dozen repeats, her child may have 13 or 14. At some point, the repeats reach a tipping point—mothers who have 55 or more often have children with hundreds of repeats—which caused the anomaly that Sherman noticed
Carriers of the pre-mutation can have their own challenges to deal with: fragile X-associated tremor/ataxia syndrome and fragile X-associated primary ovarian insufficiency.
“What we found out about fragile X syndrome was a fundamental change in the way we think about genetics,” Warren says in his iBook interview. “Ultimately, we found that the cause of the mutation was a long expansion of a simple repeat. That had never been discovered before in any genetically studied organism, let alone human disease.”
The finding was instructive for researchers studying other disorders such as Huntington’s disease and amyotrophic lateral sclerosis (ALS), which have also been linked to triplet repeats, he adds.
Warren provides glimpses of how the genetics emerged, in the days before the Human Genome Project. He notes how researchers used homegrown pulsed-field gel electrophoresis equipment, which were not commercially available at the time, for analyzing especially large DNA fragments.
To explain the origins of the genetic mutation, Konomos turned to molecular animation, a specialty that is becoming increasingly sophisticated. Depicting how cells’ DNA copying machinery can slip took weeks to get right, he says. Computer models of relevant proteins from the Protein Data Bank were brought into Cinema 4D, a software used for medical and commercial animation. Konomos taught himself the software along with a molecular plug-in, EPMV.
Showing the effects of FMR1’s silence on neurons and thus, how fragile X syndrome perturbs learning and memory, was even more of a challenge. One scene, a section depicting the alterations of proteins inside the dendritic spine of a neuron, was particularly difficult to pull off.
“How do you accurately portray how molecules interact at the synapse, or in the nucleus?” he says. “Molecules move by random motion. They don’t have brains. They aren’t on a mission. They are just floating and to some degree bouncing around…I had to tell these little guys to run around, but not TOO much. Basically, it was like have a bunch of dogs running around inside a fenced-in little dog park, and trying to direct the dogs to go in certain ways at certain times.”
Twists and turns
The iBook doesn’t dive into this as much, but Warren’s work on fragile X led eventually led to clinical trials, which have had their own twists and turns. A wave of enthusiasm for fragile X clinical trials resulted in disappointment. Emory experts say that along the way, investigators have learned a great deal about how to design clinical trials and how to measure a child’s progress.
“Designing clinical trials for intellectual disability is just tough,” says Warren. “It’s not like measuring blood pressure.”
A decade ago, Warren’s collaboration with Mark Bear at Brown/MIT, which started through a chance meeting at a Howard Hughes Medical Institute conference, built an influential idea of how the neuronal basis of fragile X syndrome might be treatable: the mGluR5 theory.
FMRP, the protein encoded by the FMR1 gene, restricts protein synthesis in neurons. It ensures that changes at critical neuronal connections take place in response to outside signals. In FMRP’s absence, protein synthesis occurs indiscriminately. The mGluR5 theory proposed that inhibiting a particular neuronal receptor (mGluR5), whose role is to excite protein synthesis, could compensate for the problem.
The idea was tested in mice and then in clinical trials, in which drugs targeting mGluR5 glutamate receptors were tested in adolescents and adults. In humans, mGluR5 drugs did not show clear benefits; re-evaluation suggests the choice of outcome measures, drug tolerance, and the ages of study participants may have played a role.
“Fragile X syndrome has a genetic origin, but there is great variability,” says Ami Klin, director of Marcus Autism Center, the country’s largest center for clinical care of autism. “On top of that, a child’s environment and upbringing are overlaid upon the genetics. Disability accrues over time.”
That means that focusing on children at an earlier age and a narrower age range, although more difficult to implement, could be wiser, Klin says. In addition, initial studies relied on questionnaires filled out by parents, which didn’t provide that much fine detail. Tracking more sophisticated behavioral measures will be key to evaluating a child’s progress, he says.
Recently, one of mGluR5 clinical studies has been revived in younger children (ages 3 to 6), supported by NINDS. The clinical trial looks at the effect of an intensive language intervention aimed at improving communication skills, paired with either a mGluR5 drug called AFQ056 or placebo. Talboy’s center at Emory is one of the sites, starting in the fall of 2018.
“We are really evaluating the child’s ability to learn language,” Talboy says. “This is a critical period, when a child’s brain is still developing. The time frame is actually longer than in previous studies.”
Another pharmacological strategy for the treatment of fragile X syndrome gained support from the Warren lab’s work with Drosophila fruit flies. His team found that flies with mutations in their version of the FMR1 gene were especially sensitive to having glutamate in their diet. (This was a serendipitous discovery, because lab-prepared food was superior to commercial food.) GABA, a key mover in an inhibitory pathway in the brain, could keep the flies alive and rescue behavioral defects.
A drug that acts upon one type of GABA receptors, arbaclofen, made its way to clinical trials in adults, and in children as young as 5. Emory Medicine had a feature on the family of a boy who was participating in the arbaclofen study. “Samuel is a very happy, easy-going, joyful boy,” says his mother. He loves trains, baseball, and riding his Big Wheel.
Unfortunately, these studies ran aground as well. Still, clinical trials, like the one Samuel participated in, do help researchers understand the best ways to measure children’s cognition and behavior. The Simons Foundation, which supports autism-related research, has acquired the rights to arbaclofen, with an eye on a future re-do.
Cell biology chair Gary Bassell, collaborating with Shannon Gourley at Yerkes and his former postdoc Christina Gross at Cincinnati Children’s, has been developing an alternative drug strategy. It is also aimed at taming indiscriminate protein synthesis, but with a different target: a particular form of the enzyme PI3 kinase. In a recent paper, the three labs showed that an inhibitor of p110beta PI3 kinase relieved symptomatic behaviors, such as impaired social interactions and inflexible decision making, in the mouse model of fragile X syndrome.
“We can’t use mouse behavioral tests alone to understand a drug’s effects,” Bassell says. “It is critical to have molecular, cellular and neurophysiological phenotypes, which we and others do.” (See two related items from Spectrum News on this topic. Elizabeth Berry-Kravis + mouse models, more recent roundup including Bassell’s work)
For his part, Warren thinks that drug strategies aimed at replacing FMRP’s regulation of protein synthesis target just one aspect of its function. His lab showed that the tendency of children with fragile X syndrome to develop seizures is independent of regulating protein synthesis.
“The most effective strategy is likely to be reactivating the fragile X gene,” he says, adding that this could be possible through epigenetic approaches or even gene editing. “After all, the gene itself is intact. There’s nothing wrong with it, except that it’s turned off. That’s what I’d put my money on.”
One of the reasons big pharmaceutical companies were interested in fragile X was because it was perceived as a gateway to the more common (and more heterogenous) diagnosis of autism. Now, more in the field are emphasizing the fine distinctions. Warren was quoted in a 2014 story in the Simons Foundation’s Spectrum News:
Children with autism and those with fragile X syndrome both shy away from social contact, have trouble making friends and avert their gaze when people look at them. But children with fragile X syndrome often sneak a peek when the other person turns his back, researchers say. Children with autism, in contrast, seem mostly uninterested in social interactions.
“Children with fragile X syndrome all have very severe social anxiety that plays a big role in the perception that they have autism,” says Stephen Warren, professor of human genetics at Emory University School of Medicine in Atlanta. “They are actually interested in their environment; they are just very shy and anxious about it.”


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text:
Once upon a Tom in Hollywood’s review published on Letterboxd:
I don't know who to trust.
I know what you mean, Blair. Trust's a tough thing to come by these days.
Thanks to my aversion to synthesizer music and my inability to suspend disbelief when it comes to blood and gore, I think it's fair to say that John Carpenter and I are never going to totally get along. But The Thing is truly the exception that proves the rule.
This movie is so many things at once. It's got the "who's the mole?" mystery of an espionage thriller; the "don't let it infect me" hysteria of a zombie movie; the demented creature effects of a Cronenberg flick; the nail-biting suspense of a haunted house horror; and the superior firepower of an old-school Schwarzenegger shoot-em-up (seriously, why do research bases have so many flamethrowers and hand grenades?).
It's all played completely straight with little to no ham, making this the most restrained (and best) performance in the illustrious career of Kurt Russell. And it's also the best John Carpenter film (though, embarrassingly, I still have never seen the original Halloween all the way through). Highly Recommended.
Added to: Top 20 Horror Movies

domain: artistic


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Maria's Pisco Cake is a dense, moist, delicious cake made with Peruvian Pisco which delivers a wonderful fragrance as well as flavor. It needs no embellishments; just slice and enjoy with a cup of coffee or glass of milk.Serves 12 - 14
Butter and flour a Bundt or tube pan. I use the wrappers from the butter to grease the pan then add a little more if needed to fully coat the pan. Then add a little flour and tap to coat the entire inside of pan. Discard any loose flour. Alternatively, you can use a baking spray.
Beat butter for 1 minute and gradually add sugar. Beat 5 minutes on medium high speed until pale and creamy.
Meanwhile, combine the flour, baking powder, and salt in a separate bowl and set aside.
Combine the milk, pisco, and vanilla in a measuring cup and set aside.
After 5 minutes of beating the butter and sugar, add eggs one at a time, incorporating fully after each one.
Scrape down bowl.
Add in half of flour and beat until just combined.
Stream in all the milk and beat to incorporate. It may look curdled but it will come together after adding more flour.
Add remaining flour and mix just until combined.
Scrape down bowl and beat another 20 seconds.
Pour into prepared pan and even out.
Bake for 1 hour 10 minutes but check after 65 minutes.
Let cool in pan 15 minutes.
Turn out onto cooling rack and let cool completely. Serve and enjoy.
Are your eggs cold? No problem. Just place the eggs in a bowl of very warm water for about 5 minutes and your eggs will be ready to go.


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Europe underwent profound upheavals in the decades immediately following the downfall of Napoleon, and that tumult was the result of a series of economic, political and social changes whose origins reached back into the eighteenth century. Starting with a superbly concise explanation of the Industrial Revolution, authors Garrett and Godfrey explore the intricate series of events that followed on the heels of a conservative reaction to Napoleon's defeat. With varying degrees of success, the victorious Allied powers sought to reinstall monarchy and religious authority throughout Europe. Hovering over this diplomatic finery was the reactionary figure of Prince von Metternich of Austria, a supremely gifted statesman who remained at the center of a glittering aristocratic European stage for 35 years. But the aristocratic reaction could not contain the surging demand of the new middle classes emerging in the wake of the titanic forces unleashed by the Industrial Revolution. In a series of revolutions and counter-revolutions, Europe became convulsed by one political crisis after another as each kingdom in its turn grappled with the bewildering set of changes and demands that seemingly appeared at every turn. But middle class patriotic fervor could not be denied, and inevitably revolution led to nationalism and the formation of new states like Italy, Germany, Hungary, Rumania, Greece and others. Despite all the crafty diplomatic initiatives and schemes put forth by Metternich and his conservative comrades, the old monarchies and religious institutions came under increasing pressure from a brash new order of liberal democrats, radical intellectuals, and progressive autocrats. Change was in the air and Louis Napoleon of France, among others, was determined to ride the swirling currents of a divided and aroused electorate to a political position of undisputed power. 1. Language: English. Narrator: Charlton Griffin. Audio sample: http://samples.audible.de/bk/acon/000090/bk_acon_000090_sample.mp3. Digital audiobook in aax.
A sociology-philosophical-literary study focusing on the consequences the downfall of Positivist philosophy and weltanschaung brought to the Western hemisphere. All in all an unprecedented crisis of consciousness. The Positivist era, based on unlimited scientific optimism, at the turn of the century failed to keep up with its promises. History proved it wrong: the contradiction of the industrial revolution reveals that evolution not always is synonymous of progress.The unleashing of vulgar imperialism confirms that the romantic nationalism easily turns to be a violent colonialism guilty of forgetting the liberal premises through which should have happened man's liberation. An evident shame blows over European consciousness for having betrayed bourgeois ideals and for having misread history. Science seems to be guilty. The bracket 1890-1930 stretches to a death point while suggesting that the origin of everything is placed in an irrational dimension, a vague and opaque zone which is unreachable unless through an epiphany. Western civilization is at loss, shaped by an unprecedented cultural crisis. The dawn of a new age or the end of history?
Part memoir, part remedy for the state we're in, with liberal sprinklings of common sense, Chris Patten's Not Quite the Diplomat is a frank and funny book from a very outspoken politician.After spending several years in the thick of international events, Chris Patten has seen rather a lot of the world - and the people who run it. And now he's free from the bonds of diplomacy, he doesn't have to be quite so careful about what he says.Here he gives us his forthright views on everything from the Tories' downfall to America's empire, from whether Blair has any political convictions to why Britain should start liking the French.'Masterly, elegant, sprightly, wry ... the best political reading of the year'James Naughtie, The Times Books of the Year'A garnering of rich personal experience ... Frank and vivid ... without betraying any confidences or relationships of trust (Sir Christopher Meyer, please note)'The Times Literary Supplement Books of the Year'Elegant, warm, witty, stylish and readable ... If politics were sane, appointments to ministerial rank anywhere would be conditional on reading, digesting, understanding and acting upon the wisdom of this book'Independent'Patten writes with wit, elegance and passion, showing a candour and courage uncommon among politicians'Sunday TelegraphChris Patten is currently Chairman of the BBC Trust, and Chancellor of Oxford and Newcastle Universities. He is well known for being the last Governor of Hong Kong 1992-97, about which he wrote in East and West (1998). Both that and his most recent book, Not Quite the Diplomat: Home Truths about World Affairs (2005), were international best-sellers.
This book sets out a concrete analytical and empirical framework to understand the Euro-zone crisis and the deep disintegrative tendencies of Euro-Atlantic neo-imperialism. It explores how the authoritarianism and austerity led from above in the transatlantic world cultivate right-wing populism and racist hysteria from below, especially in relation to the global power-shift to China and other emerging economies. The authors argue that ordoliberal/neo-liberal austerity cannot reverse the decline of western economies, if anything, it precipitates their downfall and the re-launching of globalization under Asian primacy. The book will appeal to students, scholars and policymakers across the fields of International Political Economy, European Politics and Critical Social and Political Theory.
Donald Trump’s election has called into question many fundamental assumptions about politics and society. Should the forty-fifth president of the United States make us reconsider the nature and future of the global order? Collecting a wide range of perspectives from leading political scientists, historians, and international-relations scholars, Chaos in the Liberal Order explores the global trends that led to Trump’s stunning victory and the impact his presidency will have on the international political landscape. Contributors situate Trump among past foreign policy upheavals and enduring models for global governance, seeking to understand how and why he departs from precedents and norms. The book considers key issues, such as what Trump means for America’s role in the world; the relationship between domestic and international politics; and Trump’s place in the rise of the far right worldwide. It poses challenging questions, including: Does Trump’s election signal the downfall of the liberal order or unveil its resilience? What is the importance of individual leaders for the international system, and to what extent is Trump an outlier? Is there a Trump doctrine, or is America’s president fundamentally impulsive and scattershot? The book considers the effects of Trump’s presidency on trends in human rights, international alliances, and regional conflicts. With provocative contributions from prominent figures such as Stephen M. Walt, Andrew J. Bacevich, and Samuel Moyn, this timely collection brings much-needed expert perspectives on our tumultuous era.

domain: library


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This Facebook status from a favorite historian of mine, Robert Higgs, inspired my political musing:
Suppose I said, murder is wrong and I advocate that people stop committing murder or supporting those who do commit it. Now, sure enough, along comes someone to tell me how utopian and impractical I am, pointing out that historically murder has always been committed everywhere that humans have lived together. Clearly murder has demonstrated its social superiority as a form of social behavior. Murder has revealed itself as the “fittest” sort of behavior in the evolutionary shakeout.
Do you accept this argument about murder? If not, why do you accept it when we substitute “the state or a similar ruling organization” for “murder”?
Why I support anarchy is really an utterly simply matter: I’m opposed to genuine crime. The state is a criminal organization, and I therefore oppose it. Telling me that states have always existed or that nonstate alternatives would not be viable in competition with states does not dissuade me one bit. I’m still opposed to criminal actions — you know, theft, extortion, murder, kidnapping, and all the other criminal actions the state takes to sustain itself.
I’ve been thinking a lot about this lately. I’ve identified with libertarianism since I got into politics at age 17 and I haven’t wavered on that position. I’m not sure why I had a propensity toward libertarianism and the ideals expressed; I’m not sure what happened or influenced me growing up to have that propensity, but once I stepped into politics, I went to libertarianism.
However, I’ve known ever since I discovered libertarianism its inherent contradiction as a political philosophy. Consider what the libertarian says: We think the government is inherently bad and the market is better able to handle X, Y and Z. But we’re not for disbanding the government. We just want to limit it to its so-called essential functions, the reasons why it exists (mostly per the U.S. Constitution): provide for the defense, provide courts and that’s about it. Does that contradiction not seem apparent? Let me spell it out, then. If the market on principle is better able to do X, Y and Z than the government, then why is the market on principle not also able to provide for the defense and the courts, thus eliminating altogether the “necessary evil” of the government?
Even beyond such an inherent contradiction in the philosophy, consider that the most egregious examples of state abuse are often concentrated in those areas deemed a “necessary evil” by libertarians. The government is perpetually starting war and using that war as an excuse to erode civil liberties at home, spy on all Americans and so on. Not to say anything about killing untold numbers of innocent civilians overseas, which then also, ironically, puts us in danger. As for the courts, looking at the numbers, it’s clear that the U.S. justice system is seriously fucked up. The use of the death penalty, the number of people locked up that are mentally ill, the number of people locked up for nonviolent crimes, the use of solitary confinement, the racial disparity, the over-reliance upon faulty crime labs, the problems involved in the police (which are too numerous to even briefly mention) and so on.
Again, where does the libertarian derive the legitimacy for the government to monopolize defense and courts? So, pertaining to Mr. Higgs’ status, is not the necessary logical and intellectual evolution of the libertarian — the end-game, if you will — anarchism? And again, to that, I think the onus is on the people that believe in the legitimacy of the government to prove why it ought to be considered legitimate in the face of all that it does. I’ve only touched upon those areas libertarians actually think are legitimate, much less the areas beyond that scope.
I oppose the legitimacy of the state in the purest of my ideological manifestation because as an apparatus, I think it does far more harm to individuals than makes it worth keeping around. If we were starting a society from scratch, the very notion of the government seems absurd merely on the face of it: Oh, okay, we’ll give you all the power of the law, the guns to back up the power of that law and here, have some money to fund it all.

domain: law


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Getting over a broken heart and soul is a problematic process, however it can be done. The secret to success is to understand that you are not together and that absolutely adore will find you again.
It might be hard to get encouraged, but you need to take action. Start by making a summary of things you need to do. If you have a friend, ask them to tag along. If you’re functioning best asian girl to marry out, combine that with another thing you enjoy, just like dancing to upbeat music or seeing a TV show.
Take the time to do actions that will help you feel better. Getting back with your old hobby can help you restore confidence. You may also meet new people.
The best way to get over a broken center is to surround yourself with supportive persons. You may not manage to find another partner without delay, but you will shortly begin to feel better. If you have a problem, consider observing a specialist. You can also search on the internet for sufferer testimonials.
You may also want to try meditation. This will likely assist you to release your emotions and quiet your thoughts. You can also make an effort yoga. It can benefit you discharge your feelings, improve your mental health, and reduce anxiety.
Remember, it will need time to recover a damaged heart. The best way to conquer a shattered Heart is always to take care of yourself and give your self the space you require to heal. You must practice self-compassion, and you need to learn to accept yourself as you are.

domain: psychology


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BREAKING: Dawn of War III Announced!
You heard that right – Dawn of War III is Coming! Get ready to have your mindblown…
via the Dawn of War channel on YouTube
After years of secrecy, we’re finally ready to confirm that the game you’ve been waiting for will soon be a reality. It’s been so hard to hold in our excitement and we can’t wait to show you everything we have in store. For now, check out the official Dawn of War III trailer for your first look!
We hope you’re as excited as we are, and we’re sure you have a lot of questions. Luckily, you’ve come to the right place for all the latest news and updates from the Dawn of War III team. Follow along as we slip deeper into the darkness of endless war on our social channels, and let us know what you think on our brand new forums!
Today is only the beginning. Get ready for the biggest Dawn of War yet…
SPOILERS BELOW – Really, just watch the video!
Still here? Good..
The Blood Ravens are BACK!
So are the ORKS!
And the Eldar…
Who have some NEW FRIENDS…
Who fight with Imperial KNIGHTS!
THIS. IS. AWESOME.
Dawn of War 2 was released in 2009. You will remember everything was left in limbo after THQ dies and SEGA picked up the 40K license from the carcass.
Well the wait is OVER – Dawn of War III is coming!!!
Are you prepared for the return of Dawn of War!?

domain: entertainment


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As an alternative, it is possible to obtain a Cypriot visa form by sending a visa form request letter to the Cypriot consulate a stamped envelope bearing your name & address. To acquire the listing of necessary documents to submit an application for your visa, include photocopies of the main pages of your passport, i.e. visa stamp pages. It’s also possible to ask for Cypriot tourist visa application form by phoning the Cypriot embassy visa form request line. Various phone fees may apply for this service. To check out whether you need to have a tourist visa to go to Cyprus, why not head over to Cypriot visa requirements.
You may also obtain Cypriot business visa form by calling the Cypriot embassy visa form request phone line and different phone fees may apply for the service. For additional information about Cypriot visa for your travel to Cyprus, be sure to click on Cypriot visa requirments.
Travellers must check personally to make sure that information and facts of particular importance for them is correct. We are not liable for decisions taken by travelers based on information contained in this website.
Usually, you can include dependent children on your visa application if they’re traveling together with you on your passport. You might not need to submit an application for this kind of visa. Find out more
Please note: Be sure to obtain the correct Cypriot visas where necessary and it is your duty to secure them. As a general rule countries demand passports to be valid for six months immediately after the expiration of the visa. NB: Possessing a visa will not guarantee an individual entry on arrival in Cyprus.
Individuals must check personally to make certain that details of specific relevance to them is correct. We are not liable for decisions taken by travelers based on information and facts included in this web site.
Please feel free to voice your own experiences with the Cypriot Embassy in Abu Dhabi, United Arab Emirates. Whether you’re getting a visa for visiting Cyprus or notarizing paperwork or simply just planning to chat to a person at the Cypriot embassy in Abu Dhabi. Let us know simply by posting it on this site.
Please Be aware: Your remarks are going to be viewed by the general public, because of this you should not include confidential details.


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A wide-ranging flaw affecting millions of Samsung devices has been found, and is being described as a huge vulnerability.
The flaw was discovered by the research firm NowSecure, and in a detailed report, they outlined all the information that could be taken from your device if hackers gain access using the flaw.
As many as 600 million devices could be hit by the vulnerability, and hackers could "gain access to a device's sensors, including the GPS, camera and microphone, install malware and even listen to phone calls and messages". The flaw came about as a result of Samsung's implementation of SwiftKey keyboards on its devices, but even if you use a different keyboard, there's still a chance you could be hit.
The list of devices hit includes the Galaxy S6, S5, S4, S4 Mini and SIII, while NowSecure state that other devices and models may also have been affected.
However, speaking to Mashable SwiftKey CMO Joe Braidwood stated that the risk of getting hit is relatively low: "the vulnerability in question is not easy to exploit: a user must be connected to a compromised network (such as a spoofed public Wi-Fi network), where a hacker with the right tools has specifically intended to gain access to their device. This access is then only possible if the user’s keyboard is conducting a language update at that specific time, while connected to the compromised network."
Samsung stated that they would be rolling out a security update over the next few days as a result of the vulnerability and "are also working with SwiftKey to address potential risks going forward".

domain: news


Osteoarthritis has become one fo the most common and debilitating age-related diseases in the United States today. As with all diseases prevention is key so you may be excited to learn that a new study has revealed a possible treatment strategy.
Researchers at The Scripps Research Institute (TSRI) in San Diego, CA, reveal that proteins called FoxO are key for joint health. They have found that if they can boost the levels of FoxO proteins in the body then they might have found a way to treat osteoarthritis, or, better still, even stop the disease from developing.
Senior study author Dr. Martin Lotz, from the Department of Molecular Medicine at TSRI and his team recently reported their results in the journal Science Translational Medicine. The link at the bottom of the article will take you to the actual results.
It is estimated that approximately 30 million adults in the United States alone are suffering with Osteoarthritis. These staggering statistics make it the most common type of arthritis which is also referred to as degenerative joint disease. In basic terms it is the breakdown of cartilage. Cartilage is normally present on the ends of each bone as they meet to form the joint. The cartilage literally acts as a buffer to prevent the two bones from rubbing directly against each during movement and also as a cushion during activities that promote impact. The disease affects the cartilage by breaking it down and leaving bone on bone which causes reduced range in motion and severe pain. The joints that are most affected are the knees, hips and joints of the hands.
In a previous study completed by Dr. Lotz and his team they found that FoxO proteins were reduced when cartilage was reduced. From their latest study they also found that reduced levels of FoxO proteins meant that the cartilage broke down at a much younger age and also did not provide the same level of cushioning during activity.
At the moment the research is still in its’ infancy. The next stage will be to create molecules that can increase FoxO levels and then assess their effects in experimental osteoarthritis models. They are hopeful that drugs that boost the expression and activity of FoxO could be a strategy for preventing and treating osteoarthritis in the future.


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Two sons of Libyan leader Muammar Gaddafi have reportedly proposed a transition to a constitutional democracy that would include their father’s removal from power.
The New York Times cites on Monday a Libyan official as saying the transition would be spearheaded by Gaddafi’s son, Seif al-Islam.
One person close to the sons said the father appeared ready to accept the deal, the paper noted.
The two sons “want to move toward change for the country” without their father, the Times quoted one person close to the Seif and Saadi camp as saying.
According to the Times, the idea may reflect longstanding differences among Gaddafi’s sons.
While Seif and Saadi have leaned toward Western-style economic and political openings, Colonel Gaddafi’s sons Khamis and Mutuassim are considered hard-liners, the paper said.


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"An electronic-infused marvel that skilfully uses its artform to portray a deep message."
Broken 8 Records, 30th July 2017
Watch Live Shows on YouTube
Past shows now available from 2016 onward
Although venues are still closed in the UK, shows are streaming online including various Pride appearances and cabarets - plus of course the legendary January 2020 show at Cadogan Hall London in support of The Pink Singers.
- "The queer Victoria Wood" - Yorkshire Evening Post
- "An LGBT+ driven musical trinket box" - Get In Her Ears
- "A tonic to the heart" - Rainbow Exotic Music
The Spectrum EP
Out on CD & digital
Featuring five alternative versions and remixes from the first two albums as performed on the Rainbow Heart 2018 tour, recorded with a host of live musicians.
- "Seductive, sassy pop" - The Faulkner Review
- "Honest, spontaneous and accomplished" - The Bandcamp Diaries
- "So diverse in style" - Act/One
Clara's A Winner At Film Festival
TV period drama Clara with an orchestral score by Jessica has won two awards at the prestigious South Coast Film Festival 2020.
Live Session for Dundee Pride 2020
A four-song live set will be broadcast on Twitch as part of Dundee's Virtual Pride celebrations.
Trans Radio UK Virtual Pride
The Bleeding Obvious will perform a short set for Trans Radio UK's Virtual Pride on Sunday 5 July.
Virtually Grampian Pride 2020
Aberdeen's Grampian Pride is the latest virtual appearance for The Bleeding Obvious, on Saturday 30 May.
On this day in 2017...
Studio demos are recorded for 'Swoon', a spoken-word and music collaboration with poet Ralph Dartford.


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Glacier Warming – Feeling the heat!
The records for the summer of 2006 when finalized, showed that around the globe they called it the hottest summer in 100 years – maybe in centuries. Your editor, although a strict preservationist and devotee of nature, is not a “save the snail darter“, tree-hugging greenie. Having said that, I am truly concerned, yet I have an open mind as it relates to cyclic weather patterns and yet-to-be-proven global warming as a result of man-made effluence.
I am not afraid to admit that because I do not have all the answers, I am not supporting either side of the global warming debate. The key phrase is “all the answers“; we just don’t know for sure if mankind is ruining the world or if this is nothing more than a cyclic pattern of a very resilient planet. However, I would rather err on the side of caution than dismiss evidence outright. With this in mind, I plan to begin logging news stories about this dilemma in chronological order.
I monitor Google and Yahoo! news alerts on a daily basis. As stories appear about this subject – relating to Glacier National Park – I will list them on these pages with the most recent at the top of the list.
Breaking the ice – Glaciers that took millennia to build are now vanishing with the summer sun. Within the next half century, scientists believe, the park’s name may do little more than conjure up scenic images of Glacier’s past geology.
At Risk: America’s National Parks – Glaciers, wildlife and forests could disappear entirely from Western national parks because of what a new report by environmental advocacy groups calls the single greatest threat: global warming.
Climate change seen hurting national parks – We may lose the glaciers in Glacier National Park,” where scientists have projected a total melt in 25 years…. Already scientists note signs that may indicate that the tree line is moving upward in elevation.

domain: geography


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- 作者列表："Deshmukh V","Tripathi SC","Pandey A","Deshmukh V","Vykoukal J","Patil A","Sontakke B
OBJECTIVE:Recent worldwide outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of respiratory coronavirus disease 2019 (COVID-19), is a current, ongoing life-threatening crisis, and international public health emergency. The early diagnosis and management of the disease remains a major challenge. In this review, we aim to summarize the updated epidemiology, causes, clinical manifestation and diagnosis, as well as prevention and control of the novel coronavirus SARS-CoV-2. MATERIALS AND METHODS:A broad search of the literature was performed in "PubMed" "Medline" "Web of Science", "Google Scholar" and "World Health Organization-WHO" using the keywords "severe acute respiratory syndrome coronavirus", "2019-nCoV", "COVID-19, "SARS", "SARS-CoV-2" "Epidemiology" "Transmission" "Pathogenesis" "Clinical Characteristics". We reviewed and documented the information obtained from literature on epidemiology, pathogenesis and clinical appearances of SARS-CoV-2 infection. RESULTS:The global cases of COVID-19 as of April 2, 2020, have risen to more than 900,000 and morbidity has reached more than 47,000. The incidence rate for COVID-19 has been predicted to be higher than the previous outbreaks of other coronavirus family members, including those of SARS-CoV and the Middle East Respiratory Syndrome Coronavirus (MERS-CoV). The main clinical presentation of SARS-CoV-2 infection ranges from asymptomatic stages to severe lower respiratory infection in the form of pneumonia. Most of the patients also presented with fever, cough, sore throat, headache, fatigue, myalgia and breathlessness. Individuals at higher risk for severe illness include elderly people and patients with a weakened immune system or that are suffering from an underlying chronic medical condition like hypertension, diabetes mellitus, cancer, respiratory illness or cardiovascular diseases. CONCLUSIONS:SARS-Cov-2 has emerged as a worldwide threat, currently affecting 170 countries and territories across the globe. There is still much to be understood regarding SARS-CoV-2 about its virology, epidemiology and clinical management strategies; this knowledge will be essential to both manage the current pandemic and to conceive comprehensive measures to prevent such outbreaks in the future.
目的: 呼吸系统冠状病毒疾病 2019 (新型冠状病毒) 的病原体SARS-CoV-2 (新型冠状病毒肺炎) 是最近在世界范围内爆发的，是当前威胁生命的危机和国际突发公共卫生事件。该病的早期诊断和治疗仍然是一个重大挑战。本文就新型冠状病毒流行病学病因、临床表现、诊断及预防控制等方面的SARS-CoV-2 进行综述。 材料和方法: 在 “PubMed” “Medline” “Web of Science” 中对文献进行广泛检索，“Google Scholar” 和 “世界卫生组织 (World Health Organization)-“ 使用关键字 “严重急性呼吸综合征冠状病毒” 、 “2019-nCoV” 、 “新型冠状病毒肺炎，传染性非典型肺炎”，“传染性非典型肺炎-CoV-2” 流行病学 "" 发送"“发病机制” “临床特征”。我们审查和记录所获得的信息文献流行病学、发病机制及临床表现的SARS-CoV-2 感染. 结果: 全球新型冠状病毒肺炎病例数 2 0 年 4 月 2 日已上升至 900,000 以上，发病率达 47,000 以上。的发病率为新型冠状病毒肺炎预测高于以往暴发的其他冠状病毒家族成员，包括传染性非典型肺炎-CoV和中东呼吸综合征冠状病毒冠状病毒 (MERS-CoV).SARS-CoV-2 感染的主要临床表现从无症状期到肺炎形式的严重下呼吸道感染。大多数患者还表现为发热、咳嗽、喉咙痛、头痛乏力肌肉疼痛和呼吸困难。患有严重疾病的高风险个体包括老年人和免疫系统减弱的患者，或患有潜在的慢性疾病，如高血压，糖尿病，癌症，呼吸系统疾病或心血管疾病。 结论: SARS-Cov-2 已成为一个世界性的威胁，目前影响着全球 170 个国家和地区。关于其病毒学流行病学学和临床管理策略的SARS-CoV-2 仍有许多需要了解的地方; 这一知识对于管理当前的流行病和构想防止未来此类疫情爆发的全面措施至关重要。
METHODS::Since mid-December of 2019, coronavirus disease 2019 (COVID-19) infection has been spreading from Wuhan, China. The confirmed COVID-19 patients in South Korea are those who came from or visited China. As secondary transmissions have occurred and the speed of transmission is accelerating, there are rising concerns about community infections. The 54-year old male is the third patient diagnosed with COVID-19 infection in Korea. He is a worker for a clothing business and had mild respiratory symptoms and intermittent fever in the beginning of hospitalization, and pneumonia symptoms on chest computerized tomography scan on day 6 of admission. This patient caused one case of secondary transmission and three cases of tertiary transmission. Hereby, we report the clinical findings of the index patient who was the first to cause tertiary transmission outside China. Interestingly, after lopinavir/ritonavir (Kaletra, AbbVie) was administered, β-coronavirus viral loads significantly decreased and no or little coronavirus titers were observed.
METHODS::In December 2019, a novel coronavirus (2019-nCoV) caused an outbreak in Wuhan, China, and soon spread to other parts of the world. It was believed that 2019-nCoV was transmitted through respiratory tract and then induced pneumonia, thus molecular diagnosis based on oral swabs was used for confirmation of this disease. Likewise, patient will be released upon two times of negative detection from oral swabs. However, many coronaviruses can also be transmitted through oral-fecal route by infecting intestines. Whether 2019-nCoV infected patients also carry virus in other organs like intestine need to be tested. We conducted investigation on patients in a local hospital who were infected with this virus. We found the presence of 2019-nCoV in anal swabs and blood as well, and more anal swab positives than oral swab positives in a later stage of infection, suggesting shedding and thereby transmitted through oral-fecal route. We also showed serology test can improve detection positive rate thus should be used in future epidemiology. Our report provides a cautionary warning that 2019-nCoV may be shed through multiple routes.
METHODS::There is a current worldwide outbreak of a new type of coronavirus (2019-nCoV), which originated from Wuhan in China and has now spread to 17 other countries. Governments are under increased pressure to stop the outbreak spiraling into a global health emergency. At this stage, preparedness, transparency, and sharing of information are crucial to risk assessments and beginning outbreak control activities. This information should include reports from outbreak sites and from laboratories supporting the investigation. This paper aggregates and consolidates the virology, epidemiology, clinical management strategies from both English and Chinese literature, official news channels, and other official government documents. In addition, by fitting the number of infections with a single-term exponential model, we report that the infection is spreading at an exponential rate, with a doubling period of 1.8 days.


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Apple Arcade is low-key one of the best values in gaming and as strange as it is to see Apple as the underdog in something, they came out swinging with the service and have delivered some high-quality experiences for both mobile and Apple TV users to experience. The Apple TV doesn’t have a ton of racing games available yet, with Sonic Racing and Warp Drive being the most notable yet – but it’s a about to get something new and noteworthy when Detonation Racing hits the storefront for MacOS, iOS and TVOS devices. From Electric Square, the folks behind Forza Street on Android devices, comes a spiritual successor of sorts to the beloved Split/Second.
As we’ll be covering in an upcoming graveyard, Split/Second was a gem of a game that combined thrilling racing with explosions to craft an experience that still hasn’t been matched to this day. Detonation Racing aims to do what that game did, but features a more rival-based approach and will still allow players to set traps and blow up the environment as well. We’ll be taking a closer look on the game when it hits, but it looks quite promising and will feature cross-play between all devices as well.

domain: hobby


Saudi Arabia and Iraq agree to re-open their Arar border crossing for trade for the fist time since 1990 when ties were cut following Saddam Hussein’s invasion of Kuwait. Saudi and Iraqi officials toured the site Monday. The governor of Anbar province said troops had been deployed to safeguard the desert route leading to Arar. On Monday, the Saudi cabinet decided to establish a joint trade commission with Iraq.
DEBKAfile: Both Saudi Arabia and the UAE have welcomed visits to their capitals by the influential Shiite cleric Moqtada Sadar in recent weeks as part of their effort to curtail Iran’s influence in Baghdad and the region.


Sorry ladies, but NBA superstar, Nike Basketball spokesman and Roc Nation Sports client Kevin Durant is officially off the market. You probably didn’t have enough game, on the court, to catch his attention anyway. KD is engaged to WNBA guard and former UVA star Monica Wright.
Reports the NBA:
Oklahoma City Thunder star Kevin Durant is engaged to Minnesota Lynx guard Monica Wright.
Wright confirmed the engagement following Minnesota’s 91-59 victory over the Phoenix Mercury on Sunday night.
Durant, who was selected with the second overall pick in the 2007 draft, just completed his sixth season in the NBA. The 24-year-old forward averaged 28.1 points, 7.9 rebounds and 4.6 assists last season.
Wright is in her fourth season in the WNBA. She played her college ball at Virginia and turns 25 on July 15.
KD recently unveiled his latest signature basketball sneaker, the Nike KD VI. We’re type jealous that Wright got an early pair of the KD VIs in the “Pre-Heat” colorway.
The couple has been pretty hush about their relationship but you can check out some photos of them together (mostly sublte nods to each other) in the gallery.
Congrats to Kevin and Monica. Also, Wahoowa (it’s a University of Virginia thing).


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Archaeological Evidence Reveals:
Phones Were Used By the Ancient Incas
Archaeologist Fay Kerr and colleagues from the University of
Shamrizona have unearthed artifacts that shed light on how the Inca used cellular phones to organize their sun-worship rituals and communicate with their gods.
According to Fay, "many scholars believe that the famous Inca stone pillars were actually used as cellular stations, providing full national coverage and free weekend minutes, but no physical evidence of the actual cell phones was found -- until now”.
During a survey on the Island of the Sun, in Lake Titicamocky, Fay K. team discovered the remains of a totem pole depicting Inca gods. One of the deities is clearly seen holding a cellular phone (see picture below).
The totem pole phone has a striking resemblance to the legendary Nokia 6800
The team's research indicates that, on the June solstice, the Inca king and high priests of the empire assembled in a small plaza beside a sacred rock to witness the dramatic setting of the sun, while taking pictures of the solstice with their advanced camera phones. Later, taking advantage of their rollover minutes from the previous month, they would email the pictures to lower-class pilgrims, who had to stay in a second platform outside the sanctuary wall, and were forced to pay extra air-minutes to receive the precious pictures.
Unfortunately, the primitive plans offered by the Inca cell phone providers did not include free mobile-to-mobile minutes; this forced many of the
natives to make their business calls at night, when the blessing of the sun-gods was not effective, a fact which inevitably contributed to the demise of the Inca Empire.
Supporting the new evidence is the fact that no buried wires have been found in any of the excavations “This is the ultimate proof that wireless technology has been used throughout the Inca Empire” concludes the team.

domain: history


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Former Nigerian President Olusegun Obasanjo has attributed the rising wave of banditry and kidnapping in the country to the prevailing unemployment situation. Speaking at the 9th International Trade Exhibition & Conference on Agrofood, Plastics, Printing, and Packaging in Lagos, Obasanjo emphasized the urgent need to address unemployment as a means to tackle insecurity.
Obasanjo, renowned for his passion for agriculture, stressed the importance of promoting agribusiness for food security, employment generation, and economic development. He highlighted the crucial role of agriculture in providing employment opportunities for Nigerian youths, advocating for policies that make agriculture more attractive and profitable.
The former president underscored the need for policy consistency, urging policymakers to provide a conducive environment for farmers to thrive without fear of abrupt policy changes. He emphasized the importance of affordable financing for farmers, emphasizing that single-digit loans are essential for the profitability of agribusiness ventures.
Obasanjo also called for efforts to make agriculture more appealing to Nigerian youths, who often gravitate towards other sectors like entertainment. He emphasized the need to glamorize agriculture and create incentives for youth participation.
Meanwhile, the Managing Director of Fairtrade Messe, Paul Maerz, highlighted the significance of the trade exhibition in advancing Nigeria’s agrofood and plastics industries. With over 140 exhibitors from around the world, the event aims to showcase tailored products and solutions for the Nigerian market, contributing to the nation’s economic growth and technological advancement.
On the governmental front, the Minister of Agriculture and Food Security, Abubakar Kyari, addressed the pressing issue of post-harvest losses in Nigeria. He emphasized the need to invest in cold chain infrastructure to mitigate losses and ensure food security. Kyari underscored the government’s commitment to strengthening cold chain networks through partnerships with public and private stakeholders.
In a pledge of support, the ambassador of the Kingdom of the Netherlands, Wouter Plomp, reaffirmed his country’s commitment to collaborating with Nigeria to enhance food security. Recognizing agriculture as a vital component of the Nigerian economy, Plomp emphasized the importance of creating an enabling environment for agricultural development.
The conference served as a platform for stakeholders to discuss strategies for promoting agribusiness, reducing unemployment, and ensuring food security in Nigeria. Through collaborative efforts and innovative solutions, participants aim to address pressing challenges and unlock the full potential of Nigeria’s agricultural sector.

domain: agronomy


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★ Save on your booking. Call a live agent at 866-676-7081 and use the promo code HBC4303!>
Experience Napa Valley charm at the Ascend Hotel Collection. This intimate wine country hotel is ideally situated in the heart of Napa Valley on Highway 29 with a location convenient to all the area's wineries and attractions. This Napa, CA hotel is only one hour from San Francisco, three miles from historic downtown Napa, and within minutes of Yountville's quaint shops and world-renowned restaurants. Whether exploring the region aboard the Napa Valley Wine Train, soaring in a hot air balloon or visiting area wineries, this is the perfect spot for a Napa Valley visit. Pet Accommodation: 50.00 per stay. Two pets per room yp to 25 pounds.
24-hour front desk
Outdoor pool (seasonal)
Pet Sitting & Dog Walking Services
in Napa, California.
No Pets Can Stay participating businesses found
If you are the owner of a Pet Sitting or a Dog Walking business in Napa, California and wish to add your business listing free of charge to this city please submit your info here.
Napa Winery Inn, An Ascend Hotel Collection Member August 6, 2014

domain: travel


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Here are the last two cards made with Kaisercraft my cherie, for the meantime anyway!These ones are thank you cards – I have made a huge range of cards with different sentiments with this collection, so it’s a great one for all round cards.The top card has a mix of 6′ pad papers and 12 x 12 papers, and the bottom card uses just the 6″ pad.I found some flowers in the bottom of a drawer,wound some silver thread in the back ground and finished off with a big bow and fussy cut butterfly. My roast is in the oven, my shopping list written out for this week, and now I am going to round up Nathan and his camera and take some photos of my latest makes ready to post!I must take this opportunity to welcome all my new followers, thank you for joining us, feel free to comment and join in crafty conversations! Til tomorrow….
2 thoughts on “Kaisercraft My cherie thank you..11 and 12…”
Lovely cards and well suited for any occasion and I love the butterflies
thank you shirley – I loved fussy cutting the butterflies!