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Notice of Privacy Practices Effective December 1, 2022
THIS NOTICE DESCRIBES HOW MEDICAL INFORMATION ABOUT YOU MAY BE USED AND DISCLOSED AND HOW YOU CAN GET ACCESS TO THIS INFORMATION.
PLEASE REVIEW IT CAREFULLY.
Understanding Your Health Information
- Your health record serves as the basis for:
- Planning your care and treatment;
- Communicating with other health professionals involved in your care;
- Documenting the care you receive;
- Assessing and continually working to improve the care we provide; and
- Verifying that the services billed to your health insurer were actually provided.
- Health, family, social, educational, and other information provided by you is maintained in your health record.
- Your record may also contain your screening and test results, immunization record, diagnoses, treatment, and a plan for your ongoing care. Medical and hospital reports, and other information obtained with your written permission may be part of your record.
Your Health Information Privacy Rights
Although your health record is the physical property of the DOH, the information belongs to you. You have the right to:
- Receive this notice that tells you how your health information may be used and shared;
- Ask that certain health information not to be shared with particular people or entities. We are not required to agree with your request, UNLESS the restriction is to a health plan and you have paid for items or services out of pocket in full;
- Ask us to communicate with you about your health information in a different way or at a different location.
- See and get a copy of your health information in paper or electronic format;
- Ask to have corrections added to your health information;
- Obtain a written report on when and why your health information was shared for certain purposes; and
- Obtain a paper copy of this Notice upon request, even if you have agreed to receive the notice electronically.
We are required by law to:
- Ensure the privacy of your health information;
- Provide you with this Notice which describes our legal duties and privacy practices regarding information we collect and maintain about you; and
- Notify you if a breach of your health information occurred.
- Allow you, or your personal representative, to have timely access to your record. Ask us how to do this.
- Allow you, or your personal representative, to have your record sent to a third party, by completing and signing the “HIPAA Access” form.
We shall abide by the terms of the Notice of Privacy Practices currently in effect.
However, should our privacy practices change, we reserve the right to make the new provisions effective for all health information we maintain. Any significant changes will be reflected in a revised Notice of Privacy Practices which will be available upon request or after the effective date of the change.
How Are We Permitted to Use or Share Your Information?
Without your Authorization:
Current privacy laws permit us to use and share your health information without your written authorization in certain situations.
For your treatment. For example, we are permitted to share your information with the health care providers who participate in your care.
For payment activities related to services we provide for you. For example, a bill may be sent to your health insurer which may include information that identifies you, your diagnosis, as well as the type of health care services that you received.
For administrative health care operations. For example, members of our Quality Improvement Team may use your health information to assess the care and outcomes in your situation and others like it. This information may then be used to continually improve the quality and effectiveness of the services we provide.
For public health activities. We may share your health information with public health authorities charged with preventing or controlling disease, injury, or disability.
When required by law. For example, the law requires us to report gunshot wounds to the police.
To report suspected abuse or neglect. The law requires us to report suspected abuse or neglect to Child Welfare or Adult Protective Services or the police. The report may contain health information.
For judicial purposes. For example, we may share specific health information in response to a court order, administrative tribunal request, subpoena, or discovery request.
To law enforcement officials. We may share limited health information relating to crime victims, suspicious deaths, crime suspects, and about crimes that occur on our premises; or as required by law.
To avert a serious threat to health or safety. For example, we may in good faith provide information to the police when faced with a person who is threatening to use a dangerous weapon to harm himself or others.
For care and notification purposes if you agree and do not object. For example, we may share your treatment plan with your daughter who takes care of you or notify the Red Cross of your location during a disaster.
About deceased persons. We may share health information with the medical examiner seeking to identify a person and the cause of death; and with funeral directors to carry out their official duties.
For organ, eye, or tissue donation. We may share health information for transplantation or tissue donation purposes.
For research purposes. We may share health information with researchers after an Institutional Review or Privacy Board has ensured the research proposal protects the privacy of the information.
For health oversight activities. For example, we are required to provide health information requested by the U.S. Dept. of Health and Human Services during an investigation.
For specialized government functions. For example, we may share health information with a correctional institution to ensure the health and safety of inmates or others in the facility.
To other government agencies or organizations. We may share your health information with another government agency to coordinate public benefits you may receive.
For workers’ compensation. We may share your health information to comply with workers’ compensation laws.
Business associates. We may share your information with an outside entity, such as a software vendor, who may be contracted to install an electronic database system on our behalf.
With your Authorization:
We will always ask for your written permission to use of share your information for the following purposes:
- What may constitute the sale of your PHI;
- Psychotherapy notes (if we maintain psychotherapy notes); and
- Other uses and disclosures not described in this Notice.
You may cancel your authorization in writing or by contacting us at any time; however, your cancellation will not apply to the actions already taken when your authorization was in effect.
We participate in one or more Health Information Exchanges (“HIEs”). This means that your health information and identifiers are available electronically for the purpose of treatment, payment, or health care operations. Other providers and health plans participating in these HIEs may have access to this information.
If you believe your privacy rights have been violated, you may file a complaint with the DOH and with the Secretary of the U.S. Department of Human Services. You may file a complaint without fear of intimidation, threat, coercion, discrimination, or retaliation.
To file a complaint with DOH, please contact:
HIPAA Privacy Officer
State of Hawaii Department of Health
1250 Punchbowl Street, Room 250
Honolulu, Hawaii 96813
Phone: (808) 586-4111 FAX: (808) 586-4115
To file a Privacy complaint in writing with the Secretary of the Department of Health and Human Services:
Centralized Case Management Operations
U.S. Department of Health and Human Services 200 Independence Ave., S.W.
Room 509F, HHH Bldg.
Washington, D.C. 20201
Or email: OCRComplaints@hhs.gov
To file a Security complaint with the Secretary of the
Department of Health and Human Services:
Office for Civil Rights
U.S. Department of Health and Human Services 90 7th Street, Suite 4-100
San Francisco, CA 94103
Phone: (800) 368-1019
TDD: (800) 537-7697
FAX: (202) 619-3818 Website: www.hhs.gov/hipaa (Filing a Complaint)
Note: When required, we will comply with any stricter requirements contained in 42 CFR Part 2, a federal law that governs the use and disclosure of Substance Use Disorder Treatment information.

domain: medical


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Search giant Google is working with the University of Southampton and the European centers for Disease Control and prevention to trace the spread of the new crown virus through a large number of location data collected by smartphones, foreign media reported.It is reported that the company has shared with researchers a batch of anonymous data sets from services such as maps. Although the case can not be traced accurately, it is possible to show the spread of the epidemic over a period of time at the macro level.
The data are helping researchers analyze the relationship between the way the virus spreads in different countries and the rate of transmission, while also providing insight into the effectiveness of urban closure policies in European countries, people familiar with the matter said.
Nick ruktanonchai, an expert and lecturer in epidemiology of infectious diseases at the University of Southampton, said: "we are studying the movement in the center of the European Union as a whole and examining its significance for the prevention and control of the covid-19 epidemic.".
Using geographic location data, researchers were able to test and simulate different situations. For example, if countries do not actively take coordinated measures, what will they eventually face when lifting the closure measures.
To ensure that a second pandemic does not occur in the next few months, it is clear that researchers need to race against the clock to carry out relevant research.


Find link is a tool written by Edward Betts.
searching for Spain in the Eurovision Song Contest 2016 1 found (6 total)
alternate case: spain in the Eurovision Song Contest 2016
Throw the Dice
exact match in snippet
find links to article
also charted in France and Sweden. The song represented Spain in the Eurovision Song Contest 2016, in Stockholm, Sweden.In the grand final that was held


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The Upper Deck Restaurant
Many people believe that our restaurant is "a private area, only for the golfers." Nothing could be further from the truth! We believe that you don't have to be a golfer to enjoy great food, and we would like everyone to give our menu a try!
The fully licensed Upper Deck Restaurant at Echo Ridge is a popular dining spot, welcoming not only golfers but the general public as well. While having a meal, snack or just a cup of coffee, we offer the choice between relaxing in our comfortable dining room or enjoying the outdoors on our large deck featuring views of the golf course and the beautiful Qu’Appelle Valley.
Fried egg, cheese, ham, bacon or sausage on an English Muffin 6.25
All are served with hash browns
Ham, green onion, peppers, mushrooms, cheddar cheese and a scrambled egg 13.5
Green onion, peppers, tomato, mushrooms, bacon, ham, sausage & cheddar cheese. Oh! Don’t forget the eggs! 15
Bacon, Ham, sausage with scrambled eggs and cheddar 15
Fries, cheese curds, gravy, bacon, tomatoes, sunny-side fried egg 9
Toast – 2 slices 2.5
All burgers served with choice of fries, or Garden Salad
The Masters Burger
6oz Premium ground beef patty with our signature sauce, bacon & cheddar, and all the fixin’s 15
Black & Blue
6oz. Premium patty, blackened with our special seasonings, then topped with creamy blue cheese sauce, shredded pickles and an onion ring 15
6oz patty, melted cheddar and all the “fixin’s” 12
Hot & Cool Chicken Burger
Breaded Chicken Filet, cucumber, house-made tzatziki, spicy aioli, lettuce 14
Classic Chicken Burger
Crispy breaded chicken breast, lettuce, tomato and mayo 12
Try our Weekly Burger Special!
All salads served with garlic focaccia bread
Garden Tossed Salad
Crisp greens, cucumber, tomato, red onion, shredded carrots 11.5
Fresh romaine lettuce, croutons, bacon bits, creamy dressing and shredded parmesan 13
*add chicken to any salad 4
Ham, green onion and egg folded together between your choice of bread 10
A Classic! Bacon, mayo, crisp iceberg lettuce and a fresh sliced tomato 10
Lettuce, tomato, bacon, fresh roasted turkey, ham, cheddar and mayo 14.5
All-time favourite! Ours has mozza, cheddar and Swiss 10
Taco Beef, green onion, peppers, tomatoes and mixed cheeses. Served with Salsa and Sour Cream 12.5
Flat Bread Pizza 12.5
- Pepperoni & Mushroom
- Chicken Pesto
- Ham & Pineapple
Wrap it Up!
- Chicken Caesar Wrap
Our tasty Caesar salad with crispy or grilled chicken in a flour tortilla. (spice it up by adding buffalo sauce to the chicken!) 12. 5
- Mediterranean Chicken Wrap
Fresh lettuce, cucumber, tomato, olives, red onion, feta & grilled chicken breast with our Greek dressing 12.5
“Fore” Your Fingers
- Onion Rings
- Chicken Finger Basket
- Dry Ribs*
(*) With your choice of sauce
BBQ, Greek, Salt & Pepper, Lemon Pepper, Hot or Buffalo
Try our weekly Wing Flavour!
Join us at the course for a terrific dining experience every Friday evening.
Reservations are required for sit-down dining either inside, or on the deck, and are available through our eStore at:
or simply click on the "Links" tab at the top of this page, and select "Dining Reservations"
We can also package up your meals for take-out. Just give us a call at (306) 332-4653
Steak Dinner - the house specialty
- 8oz New York Strip Loin steak, BBQ'd using our own technique, and done to your specifications. Served with a tossed salad, baked potato and garlic bread.
Steak Sandwich - a new favourite
- A seasoned 6oz steak, BBQ'd the way you like it. Served on a slice of focaccia bread, topped with crispy onion tanglers and served with a tossed salad.
- Your choice (see menu above) of our tasty varieties, baked on a flatbread crust
- a full pound basket of wings, with your choice of flavours
- a delicious, grilled 6oz patty, served on a premium bun, with all the fixin's and a side of hand-cut fries

domain: food


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The conflicted, dangerous, and empowering truth of american women's beliefs, opinions, and experiences of gun ownership and gun control -the results of which are. Smart guns are the exciting new product that the industry needs to revive lagging sales. Gun control is a highly politicized issue in the united states, for many cultural and historical reasons that no one completely understands it is often a moot topic. These articles are meant to break a complex subject into easier segments each part focuses on one topic within a larger idea this one focuses on fear fear of guns.
President barack obama’s bid to assert himself in his final year will begin with long-awaited executive actions on gun control, expected to be released next week. In 2009, we wrote an ask factcheck item for readers who wanted to know, did gun control in australia lead to more murders there last year the answer at the time. Learn about the federal and state gun control laws in the united states here's a timeline from 1791 to the present. Gun politics in the united states gun control and gun rights advocates disagree over the role that guns play in crime gun control advocates concerned. For decades, the second amendment was consigned to constitutional exile, all but erased from constitutional law textbooks and effectively banished from the nation’s.
Follow the latest gun control news stories and headlines get breaking news alerts when you download the abc news app and subscribe to gun control notifications. Comprehensive and meticulously documented facts about gun control learn about ownership rates, crime, background checks, accidents, politics, and more. President donald trump sent shockwaves through us politics during a white house meeting with lawmakers, appearing to endorse democrats’ proposals for gun control. This is concealed carry in action that poor thug never saw it coming then again he is just another stupid criminal preying on a defenseless hard.
The debate over gun control and gun rights would be more productive if both sides focused on the facts instead of pushing myths about america's gun laws. The greener police shotgun: engineered gun control these guns still tend to show up wherever the british once had colonial for crowd-control situations. Millennials are no more liberal on gun control than elders, polls show polling suggests millennials are more liberal than earlier generations on many.
Roughly two-in-three americans now say gun control laws should be made more strict.
News about gun control commentary and archival information about gun control from the new york times. Content filed under the guns and gun control taxonomy. Guns vs gun control part i: what is a gun guns vs gun control part ii: why do people like guns guns vs gun control part iii: fear this is a related article. Educate yourself and learn gun facts find out how many guns are privately owned in the us, how many gun-related deaths occur, and what gun control activists have. After the deadliest mass shooting in modern us history, the debate over gun rights is less about the weapons and more what they represent. Read the latest articles and commentary on gun control and gun rights at us news. Rep thomas massie is one of congress' top gun rights advocates.

domain: sociology


[development] Generic Authentication Bridging
adrian at bryght.com
Sat Apr 15 16:04:55 UTC 2006
On 15 Apr 2006, at 3:45 PM, Bèr Kessels wrote:
> I am esp interested in making this modle more 'general'. For example
> postgresql is theoretically supported, but I cannot test it. In
> theory one
> should be able to authenticate over a network too (using a remotely
> server) this too has not been tested, nor verified.
Currently Drupal can't make both a postgres and a mysql connection
same session, but I have a patch for that, I will be re-rolling in
the next 2 weeks.
Drupal developer and Bryght Guy
http://drupal.org | http://bryght.com
More information about the development


CEO & PRINCIPAL ENGINEER
Bobby has been involved in the radio controlled and unmanned aircraft industry since 2003. Since the time of graduating from the University of South Carolina with his Mechanical Engineering degree in 2010, Bobby has formed businesses and worked on many projects that allow him to have a well-rounded understanding of the commercial drone industry. He has spent countless days on movie sets, using drones to film stunning shots for TV shows and feature films. He has also used drones for infrastructure inspections, entertainment purposes, cargo hauling, and various other applications.
In addition to piloting, he has been designing and manufacturing unmanned helicopters and multirotors for over a decade, giving him a specialized knowledge in the design and manufacturing process of such aircraft. Having that vast experience in both design and piloting allows him to create aircraft from a pilot’s perspective that is also mechanically sound flight after flight.


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As an Amazon Associate I earn from qualifying purchases.
1. Cafe Du Monde #ad
Cafe Du Monde Coffee Chicory, 15 Ounce Ground #adCafe Du Monde #ad
- The original french market coffee stand, serving Cafe Au Laity and Hot Beignets French Doughnuts 24 hours a day, year round. This popular new orleans landmark has been located in the French Market since the early 1860's.
Can contains 15oz of ground Cafe Du Monde Coffee. Coffee and chicory. Original french Market Coffee Stand coffee.
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2. Worldwide Botanicals #ad
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- Enjoy with milk, creamer, or sweetener as desired. Sustainably harvested in northern france: chicory root is grown by french family farmers and roasted by a small family business that specializes in chicory. 100% pure roasted organic french chicory root: blend with coffee to lower its acidity and caffeine, or brew roasted chicory root by itself to enjoy France's favorite coffee alternative.
Over 40 years of experience sourcing premier botanicals: Worldwide Botanicals develops and works in partnership with suppliers to import the highest quality botanicals.
Unlike coffee, chicory doesn’t go stale or rancid. Brew french chicory root like coffee: our all-purpose grind can be brewed in any kind of coffee maker including drip, espresso and French press.
Prebiotic soluble fiber support probiotics: inulin from chicory and is a prebiotic soluble fiber that feeds probiotics and restores gut health. Support your microbiome with a daily cup of brewed French chicory root. Certified organic by QAI. Our premium freshly roasted chicory is imported bimonthly and has a 3-year shelf life. We are not always the cheapest but our botanicals are the best. It can also be steeped in a tea pot and strained through a mesh strainer.
3. French Market Coffee #ad
Medium-Dark Roast Ground Coffee, Coffee & Chicory, French Market Coffee, 12 Ounce Metal Can #adFrench Market Coffee #ad
- Our bold medium-dark roast coffee blended with imported French chicory for a caramelized sweetness. A new orleans tradition since 1890! our blends are bold, rich and handcrafted by master roasters in small batches, carefully sourced from the highest-quality Arabica beans for a flavor as soulful as the city we call home.
Made with 100% Arabica coffee beans. Enjoy this quintessential New Orleans coffee. We've been perfecting it for over 125 years! Kosher certification: This product is certified Kosher by the Orthodox Union.
4. Starwest Botanicals #ad
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- Kosher Certified. Latin/botanical Name: Cichorium intybus. 100% satisfaction guaranteed - Return Product for any reason for refund or replacement** See details below. Cgmp compliant current Good Manufacturing Practices. Origin: India.
5. Community Coffee #ad
Full Body Rich Flavorful Taste, 100% Arabica Beans, Community Coffee and Chicory Medium Dark Roast Single Serve 18 Ct Box, Compatible with Keurig 2.0 K Cup Brewers #adCommunity Coffee #ad
- Find your perfect blend: a blend for every taste; medium roast breakfast Blend for a perfect morning, Decaf, an evening cup of Signature Dark, Café Special or Coffee & Chicory New Orleans tradition for an afternoon perk, or a flavored coffee blend for a treat. Make it community: community coffee is dedicated to giving back to the communities we serve with passion for ensuring everything we do is as good as our coffee through sustainable coffee bean sourcing, giving back to single-origin coffee farms, military and education.
Enjoy 18 cups of coffee.
Rich & flavorful: born in new orleans and raised on four generations of coffee expertise, our version of this Southern favorite combines rich, roasted Arabica coffee beans with high-quality chicory for a bolder, sweeter flavor than coffee alone. We recommend trying it café au lait style with steamed milk for a more traditional flavor.
Hint of flavor: flavored coffee fan? try pecan praline, spiced pumpkin Pecan Pie, or seasonal: Sugar Dusted Beignet, Hazelnut, mardi gras king Cake coffee, French Vanilla, Dark Chocolate Peppermint in ground or single serve for Keurig K-cup brewers. Just how you like it: single-serve coffee pods k cup compatible, whole beans for your coffee bean grinder, coarse ground coffee for a French press, ground coffees for every coffee maker or steep overnight for cold brew or iced coffee.
6. Community Coffee #ad
Coffee & Chicory Medium-Dark Roast, Community Coffee, 72 Count Single Serve Coffee Pods, Compatible with Keurig 2.0 K Cup Brewers #adCommunity Coffee #ad
- 100% satisfaction guaranteed. Enjoy a total of 72 individual cups of coffee. Medium-dark roast, full body, medium brightness. Compatible with Keurig 2. 0 k-cup Brewers. Product ships as 1 box of 72 single-serve cups. Made from only 100% responsibly-sourced Arabica coffee beans.
7. Community Coffee #ad
Community Coffee Ground Coffee & Chicory Blend, 32 Ounces Pack of 2 #adCommunity Coffee #ad
- Coffee & chicory: our version of this new orleans favorite combines Arabica beans with roasted chicory for a balance of sweetness, spice & body. Community is everything: from using responsibly-sourced coffee beans to programs that support military service members, local schools & more, Community Coffee gives back to our partners & local communities in every way we can.
Only then can they be considered fit to bear the Community Coffee name.
Ground beans: we take high quality 100% arabica beans, roast them & grind them to perfection. How you like it: we've got k-cup compatible single-serve coffee pods, & ground coffees for every taste including hot, whole beans to grind for your French press, iced or cold brew.
Our ground coffee is constantly watched, brewed & tasted by our experts for rich & flavorful coffee. Try it café au lait style with steamed milk & sugar. Quality assured: all of our coffee beans go through a rigorous scoring system for body, balance, flavor & aroma.
8. Denver Spice #ad
Chicory Root-2Lb- Ingredient of New Orleans Style Coffee #adDenver Spice #ad
- Each order includes a Coupon Promotion good Toward Future Purchases. This is a mulit-Item Discount Eligble Product. Orders are processed and Shipped within 24 Hours. Packed in a heat Sealed Re-Closable Poly Pouch. Packed to Order for Optimal Freshness.
9. Community Coffee #ad
12 Ounce Bag Pack of 6, Community Coffee 100% Pure Ground Chicory #adCommunity Coffee #ad
- How you like it: we've got k-cup compatible single-serve coffee pods, & ground coffees for every taste including hot, whole beans to grind for your French press, iced or cold brew. Only then can they be considered fit to bear the Community Coffee name.
100% pure chicory: roasted chicory root is a traditional Southern ingredient that can be added to coffee for a bolder, more intense flavor or enjoyed on it's own as a natural herbal beverage.
Quality assured: all of our coffee beans go through a rigorous scoring system for body, balance, flavor & aroma. Add flavor & fiber: add community coffee 100% Ground Chicory to your favorite coffee blend or steep into tea.
Community is everything: from using responsibly-sourced coffee beans to programs that support military service members, local schools & more, Community Coffee gives back to our partners & local communities in every way we can. Naturally contains high amounts of fiber & no caffeine.


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While I was in Ohio the thrift queen herself took me to one of the most amazing places on Earth. Kaylah and I went and met her mom at a mega huge, annual sale where you can find just about everything you could ever want to thrift. We all got there really early so we had time to get in line, hang around, chat and people watch which is one of my favourite activities. Kaylah's mom is really awesome by the way and it was so great to meet her! Ok, back to the thrift finds. There was so much amazing stuff!
I really love this daisy blanket but when Ivan saw it he told me that he thought it would look really good in the shed. The way he said it was too funny for me to get mad but sorry Ivan, this guy is staying inside.
On top of the blanket is some really awesome paper that I am going to use to brighten up our built in unit in the kitchen as well as the hutch in the living room. I have actually already papered the hutch and I will share photos soonish.
I am so excited about this find! I have been dying for one of these cute plastic mail holders for the kitchen and this one just happened to be the perfect colour.
Ever since I inherited more cameras than anyone needs I have been following a strict "no more cameras" rule. But...Brownie cameras are my absolute favourite and the prices were just too good!
Kaylah also talked me into getting a Land Camera that takes AA batteries. Ok, it didn't take much convincing. When we got home Kaylah gave me a pack of black & white film to test it out and to make a long story short we figured out that this particular model only takes colour film. So...Kaylah sent me home with one of her extra land cameras that shoots black and white as well as colour.
I am already super duper in love with this camera. I ordered myself some film and I can't wait to shoot tons. The photos remind me of the ones from my grandparents albums.
One of my favourite finds was this bag that only cost me $0.50. Yep, 50 cents. It is in great shape, has the perfect back pocket for holding photobooth photos, is large enough for at least two cameras and even came with a used pair of pantyhose! Ok, so maybe that last part was not a bonus.
There is one last find, definitely the most amazing, but you will have to check out Kaylah's post to see what it is. Finding it and realizing what it was was kind of a joint effort and to save our friendship Kaylah and I decided to share it. You'll see why.
I'm sure I am forgetting to share an amazing find. I really need to make a list of my thrift finds, especially when I am travelling and everything gets packed up into different bags on the way home.
On a side note...something slightly embarrassing/funny happened during this thrift adventure. An extremely sweet girl saw Kaylah and I on the other side of an aisle and said "Hey, I read both of your blogs!". To which Kaylah & I replied (respectively)..."Ohhhhhh!" "Hiiii!" We are so eloquent. We were absolutely not expecting to run into anyone there and it was so intense and crowded that we were completely caught off guard by this awesomely nice gal. We were all laughing during this short interchange so hopefully she is still reading our blogs to see this and know that thanks to her we will always be prepared to see a blog reader and will always be ready to respond like proper human beings.
Have you found anything awesome lately? Do you have an embarrassing story about meeting a blogger/blog reader?
Wow, you guys scored!! Congrats! And that yellow bag... swwooooon!ReplyDelete
I was volunteering at The Fountain and someone came in and was like "I read your blog!!!". I was so gobsmacked that someone actually admits to reading my ramblings that I nearly fell over!ReplyDelete
Another time was when I'd written a complaint about a local restaurant (bad service, rude staff, massive delays for our food) and the assistant manager waited on our table especially! She said that when the store manager/regional manager had raised the concerns she'd looked up my blog on her phone and spent most of the morning reading it! (is that good or bad lol)
i love that daisy blanket! i have one like it that i keep in my craft room because my husband is not a fan, haha!ReplyDelete
i was at an estate sale once and i picked up this sequined santa mail holder thing and was like "wowee look at THIS!" and this girl said "wait, do you have a blog??" she recognized me because of my tacky taste. haha!
I love how you've decided to share the record player, you guys are so cute! :) Your letter holder is a great find too, it looks great against the yellow wall.ReplyDelete
Smitten with that daisy blanket, and mail holder! Okay, and every thing else too!!! I envy the finds you guys come across, I am obviously not shopping in the right places! I need to hunt!ReplyDelete
I'd love to run into you guys, too bad I live way down south!
Ummm NO JOKE, I seriously just bought an almost identical blanket at a garage sale :PReplyDelete
I wish I could find a daisy blanket like yours!! and I love your mail holder + your awesome yellow bag!! (Plus your amazing record player!!) :) xoxoReplyDelete
I love everything you found especially the letter holder. Amazing!!ReplyDelete
Haha, I am one of those people who is easily star struck and would probably freeze up with my mouth open if I saw either of you in RL. ;pReplyDelete
Aww, such awesome finds! LOVE that yellow bag!ReplyDelete
I saw Katy from Kansas Couture at a concert one time. She immediately caught my attention because she was this cute little stylish girl and I kept thinking "did I go to college with her? why does she look so familiar...OH SHIT I READ HER BLOG" and I instantly felt uncomfortable because I had been staring at her and she was alone at the time, so there was no way I was going to creep up to her in a dark venue and be like "I love your blog" Hahaha
Haha, I'm sure she understood xD I'd probably be just as awkward if someone recognized me from my blogReplyDelete
uh that mail holder is AMAZING!!!!!!! i have always wanted something like that. truly a perfect find! sounds like you had a fantastic time, very very jealous!ReplyDelete
Good grief Elycia! So much awesomeness! I especially love mail holder! Eep! So cute.ReplyDelete
I found my first pieces of Pyrex over the weekend! My first successful find ever! I guess I can't give up on thrifting now. ;-)
this is AWESOME. I'm s jealous!ReplyDelete
That mail holder is sooo darling! What a great score!ReplyDelete
Ooh I love that yellow bag, I love anything yellow at the moment! That letter rack is awesome too, great colour against your wall, fab finds!ReplyDelete
love your finds! and that is too funny about the blog reader. :D That has happened to me a couple times in Atlanta where people recognized me. I pretty much never wear make-up, and those times weren't any different & now i'm rethinking my normal no-makeup (lazy) routine. ha! I'm generally pretty shy so those interactions always throw me off, but people are always so SWEET. I love nice readers! Glad you got to meet one!ReplyDelete
I am quite in love with that letter holder! My apartment seems to be FULL of random paperwork floating around all the time. It drives my boyfriend a little nutso. haha! I'll have to scour my local thrifties and find something that works. How do you feel about your kitchen being that yellow color? I LOVE it, but am unsure how it would be for all the walls. Is it amazing?? I bet it is....ReplyDelete
Nice finds lady!
I have thrift ENVY now. Lovely finds.ReplyDelete
I am having a fabulous giveaway right here.
Yeah, haven't met a blog reader yet. But perhaps one day! The two of you ladies always find the coolest stuff. I look for cameras and such all the time and never find a thing! Perhaps I need to travel to Ohio?ReplyDelete
You got some great stuff! That blanket is adorbs, and I loooove that mail organizer! Too cute!! <3ReplyDelete
Such cute things! I love that mail holder! Absolutely perfect. I saw what you and Kaylah are sharing; SO AWESOME.ReplyDelete
Also, I was getting to a Ferris Wheel at Hershey Park and a guy who was working the ride, graduated a year before me in high school and goes, "So, how is the blog going?" as I was going around the loop. Weird.
Wow, I can't beleive the amazing things you found! That daisy blanket is just the best. In fact (this might be really creepy so bear with me), I keep buying vintage blankets in thrift stores because you always seem to have such lovely ones. Too creepy? Yeah, maybe! What I mean is, they look great in the photos of your home so they inspired me to buy my own.ReplyDelete
awkward blog reader right here. When I looked up and saw you guys I was just like "oh this is going to be uncomfortable..." but I had to say hi! awkward moments are my specialty.ReplyDelete
LOL That is a great story about Emily running into you guys. That's how you know that "it's a small world after all". Ohio is great for thrifting. I miss it so much! That camera bag for .50 cents is amazing!!ReplyDelete

domain: hobby


text:
Charles Dickens is one of the best English writers. He was born on 7 February 1812. Although his family was not poor by the standarts of the time, his father was arrested for debt.
Little Charles began to work in a blacking warehouse. When his father was set free the boy was sent to school, where he did well, and at the age of fifteen began to work in a lawyer's office.
Dickens was 19 when he became a reporter. While he was working for the newspaper "Morning Chronicle" he began to write novels. In 1837 "The Pickwick Papers" was published, the book brought him fame and money.
He worked very hard and produced many novels. His masterpieces are: "Oliver Twist", "David Coperfield", "Little Dorrit". All his writings, whether sad or happy, serious or gay are about ordinary people whose life he knew very well.
Dickens died in 1870 and was buried in Westminster Abbey. As he had wished on the stone over his grave was nothing but his name: "Charles Dickens".

domain: literature


Vodafone has announced that it will sell the Huawei MediaPad 10 Link 4G Android tablet in Australia from August, claiming it will be the "fastest tablet in Australia".
Huawei has announced the impending Australian launch of its new Ascend P6 smartphone, but the device will not be sold through traditional telco carriers.
Huawei's CEO has claimed that the Samsung Galaxy S4 is a "so-so" smartphone, and has also criticised Google's Android operating system for being "too complicated."
Chinese smartphone manufacturer Huawei is ambitiously targeting a sales figure of 10 million units for its new Ascend P6 Android phone, according to the company's CEO.
Huawei generated some buzz Tuesday with the announcement of the Ascend P6, which the company bills as the world's thinnest smartphone.
The European Union may be trying to protect its telecom equipment industry with its recent threat to investigate China over networking equipment imports. But the move could end up hurting the chances of Western vendors intent on supplying technology ...
Huawei has unveiled its Ascend Mate Android smartphone in Australia, with the 6.1in-screen device set to go on sale from Saturday 20 April.
Huawei is expected to launch a smartphone with the largest screen in the world in Australia next week, following invitations sent to local media today to attend "a bigger multimedia experience".
China has slammed a new U.S. funding law that will tighten scrutiny of information technology purchases from the country, and said it could severely damage the mutual trust between the two nations.
The vast majority of 3G and 4G USB modems handed out by mobile operators to their customers are manufactured by a handful of companies and run insecure software, according to two security researchers from Russia.
Here are a few of the Windows products we noticed while wandering around Barcelona this week
ICT solutions provider, Huawei, has unveiled what it claims to be the “world’s fastest smartphone,” the Ascend P2, at the 2013 Mobile World Congress (MWC).
Despite the launch of the iPhone 5 in December in China, Apple's smartphone market share in the nation barely grew during last year's fourth quarter, according to research firm Canalys.
Microsoft is collaborating with the Kenyan government and a local Internet service provider to provide broadband access using TV white spaces and solar-powered base stations, as part of a long-term strategy to spread mobile telephony and Internet con...
Samsung led both the smartphone and overall handsets market in the fourth quarter, though analysts' estimates of shipments and market share varied.
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The Supreme Court has dismissed the application filed before it by former governor of Imo state, Emeka Ihedioha.
Honorable Ihedioha and his party, PDP, approached supreme court, seeking a review of the January 14th judgement that sacked Ihedioha from office and instated Hope Uzodinma as the governor of the state.
In a ruling delivered yesterday, a panel of judges led by the Chief Justice of Nigeria, Justice Ibrahim Muhammad Tanko, dismissed the application on grounds that it lacked merit.
However, one of the judges out of the seven-man panel, Chima Chiweze, disagreed with the judgement.
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text:
New research shows that low sick pay may undermine Test and Trace as people on low incomes could lose £100’s of pounds if they are asked to self isolate.
In this webinar, Zoe Charlesworth presented new nationwide analysis on the Hardship Fund allocations and discussed what this means for collection rates. Megan Mclean explored what this means for those who become newly unemployed, as well as CTR support schemes. Finally, Deven Ghelani looked at what councils can do now to proactively support people.
Benefit capped households are set to double as a result of the interaction of the COVID-19 measures and the Benefit Cap. We examine why, for the GLA.
In this webinar Policy in Practice’s Head of Policy, Zoe Charlesworth, gives a comprehensive recap of the major changes to the welfare system. We were joined by special guest Victoria Todd, Low Incomes Tax Reform Group, who updated us on the latest changes to tax credits.
How well did DWP respond to the Coronavirus pandemic? Read Policy in Practice’s evidence to the Work and Pension Committee.
A recap of the key policies that make up the Coronavirus welfare safety net and the questions we’ve had from hundreds of people worried about their income.
In this webinar Policy in Practice’s Head of Policy, Zoe Charlesworth, gives a comprehensive recap of the major changes to the welfare system.
Together with RedQuadrant we discussed how to support vulnerable people through the Coronavirus (COVID-19) crisis in our recent webinar.
Zoe Charlesworth and Megan Mclean, Policy in Practice, analysed how the new measures will help households hit by Coronavirus (COVID-19).

domain: politics


text:
Are you seeking essay help? With more individuals taking classes in college and college nowadays, it isn’t surprising that there are lots of strategies to acquire your documents back in front of this grade-setters. A simple guideline would be to look into the faculty or the faculty member on which topic they are most likely to be thinking about since they will be looking for essays to perform. When you opt for a faculty, see just how much advice you get with respect to composition assistance and preparation.
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You are going to want to choose some opportunity to locate a book that offers essay help and even propose a few possible subjects the professors may be considering. Try and look at what’s offered on your individual course. It’ll not be a secret that there’s a certain quantity of essay assistance which is going to be needed, but exactly what you ought to concentrate on is the specifics of this class. Every course has different requirements for article assistance that is required and you want to know exactly what the book is boosting, in case any.
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The secret to making certain your article is on the page that you’re looking for would be to take the opportunity to pick a particular subject that’s familiar to you. If you are a very good writer, it could be quite easy for you to compose an extremely informative article, however if you’re not, you will probably realize you have some issues entering the subject area which you aren’t familiar with. As you research the content that’s provided to you, you will realize that the amount of keywords that are utilized can go into the thousands.
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Being a wonderful writer doesn’t follow that you can expect to come across the ideal composition; it simply means that you can expect to find a terrific author. Because of the large variety of essays available, it is vital that you https://www.affordable-papers.net/ try and find one that is directly from the educators to ensure that it is all up to par with the substance which has been discussed on the site.

domain: library


text:
Columbus Bond Sale Scheduled For October
314 million dollars worth of Columbus city bonds will go on sale this fall. Last November, Columbus voters approved the sale of the bonds to fund infrastructure improvements. City Auditor Hugh Dorrian.
Dorrian says 28 million dollars in proceeds from the bond sales will go to what are called 'councilmatic' projects, those approved specifically by City Council.


Published: August 2, 2010
Photo by Robert K. Yosay
Luke Holko, 5, attends a news conference announcing a day in his honor. Luke Holko Day will be the theme of Sunday’s Mahoning Valley Scrappers baseball game. Luke was injured by a foul ball at a game last September.
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There are plenty of music TV programs around the world. Through them, we are often invited to witness amazing performances and hidden talents.
I especially love watching children on these shows. It’s so admirable to see their courage as they dare stand on the big stage and perform in front of so many — and not to mention witness a potential star being born.
10-year-old Calum Courtney is a happy boy with an angelic voice. Calum also has mild autism.
Although things are not always that easy for Calum, he never gives up. Despite his autism and young age, he refuses to give up on his passion in life.
Calum has always loved singing. He recently decided to audition on popular TV talent show, Britain’s Got Talent. His family were there to support him through the tough challenge.
When it was his turn to go, Calum cautiously walked up on stage and introduced himself to the stern jury. But would he manage to keep his nerves in check and manage to sing in front of the intimidating jury and huge crowd?
When one of the jury members asks Calum if he is nervous, he answers “no”. Judge Simon Cowell looks a little skeptical and Calum’s family watch anxiously nearby.
But as soon as the 10-year-old boy opens his mouth, the jury realizes they’re about to hear something very special.
As it turns out, Calum is a real star! Inside his little body is an incredible booming voice.
Listen to Calum’s performance in the video below. Make sure to watch till the end for the jury’s heartfelt praise — and see Calum’s face when he hears it. It’s hard not to be touched.
Do you agree that Calum has a wonderful voice? Share this article with your friends so that more people can discover his amazing talent!

domain: artistic


text:
It’s not easy to get to know a new city when you’re on a tight schedule. Unfortunately, time isn’t always a commodity at one’s disposal. More often than not, work and family obligations will limit the time you can spend visiting a new place and your vacations. Or sometimes you just want to get away for a few days to escape the daily routine. Somehow managing to squeeze three off days into your agenda can be a considerable feat!
If you’re planning to travel to the Catalan capital and find yourself in this situation, you’ve probably asked yourself: what should I see in Barcelona in three days?
Barcelona is a city with plenty to see and offer. There’s so much going on here that you could stay for weeks and still not manage to see it all. However, some things are indispensable when traveling to Barcelona… Which is why we’ve put together this itinerary of what to see in Barcelona in three days. Specially curated for those of you who are on a tight schedule but don’t want to miss out on anything!
A 3-day itinerary in Barcelona
Kick-off your three day escapade in Barcelona grandly by visiting the famous Sagrada Familia. There’s a reason why all travel itineraries feature this spot. This UNESCO World Heritage Site is one of the most impressive and unique works of architecture you’ll ever see. Besides, it’s one of the city’s main landmarks. You simply can’t travel to Barcelona and not visit it. Otherwise, what will you say to your friends and family? A great starting point to your 3-day escapade in Barcelona.
The first day of our itinerary is dedicated to the works of Antoni Gaudí, Barcelona’s historic Modernista architect. After visiting the Sagrada Familia, head over to Passeig de Gràcia, where you’ll find Casa Batlló and La Pedrera, two of Gaudís most celebrated buildings. These are definitely must-sees if you’re visiting Barcelona in three days. Moreover, the Catalan capital is very well connected by public transportation and you can move around quickly to make the most out of your time.
These beautiful examples of architecture will keep you busy for a while. Complete your day by taking a stroll around Passeig de Gràcia, one of Barcelona’s most famous boulevards, where you’ll find all kinds of stores and restaurants. You’ll also find some of the best Barcelona apartments in this area, an unbeatable location to nest your headquarters.
For the second day of our itinerary of what to see in Barcelona in three days, we’re going to leave Gaudí behind (for now) and head over to the Gothic Quarter. The oldest part of the city, you’ll feel like you’re in medieval times walking through its small streets and mysterious alleyways.
Head over to Las Ramblas to start your day. La Boquería market opens its gates early at 8 am to offer the best fresh produce in the city. Pick up something for breakfast (we highly recommend the smoothies and freshly squeezed juices) and awaken your senses with all the aromas you’ll find here.
No itinerary in Barcelona would be complete without a promenade through the world-famous Ramblas. Tons of things to see here: street performers, tapas restaurants, art galleries, museums… Worthy of mention is the Liceu, Barcelona’s oldest and most important opera house.
Finish your day by admiring the sunset at Barceloneta beach, where you’ll find great restaurants specializing in freshly-caught seafood. And get some rest to tackle the last part of our itinerary of what to see in Barcelona in three days!
Our last day of our three-day visit in Barcelona will take us to Park Güell, located on the hills towards the north of the city. This is without any doubt the city’s most beautiful park and yet another one of Gaudí’s masterpieces. Visiting the park should take more than a couple of hours but it’s completely worth it. The panoramic views of the city skyline from here are unbeatable.
Finish your trip by visiting the Camp Nou, the stadium of Barcelona’s world-famous and unmistakable football team in blue and red stripes, Barcelona FC. If you’re traveling on a weekend, chances are you can even attend a match!
Follow this three-day itinerary in Barcelona and you’ll leave the city feeling satisfied but at the same time craving for more!

domain: geography


text:
Yes, it's a natural result of the plastic having aged. It's really unavoidable, and some figures utilized paint that made the condition worse (I'm thinking here of Clamp Champ, Snout Spout, Roboto, Randor and several of the Horde and Snake-Men figures.) It seems like the worst offenders are the ones that came out towards the end of the line, which may or may not be a coincidence.
Being curious, I just took all my stickies off the shelf to examine them, and 90% of them were manufactured in Mexico. The other 10% were Malaysian. None of the Taiwanese figures seem to be affected.


text:
Two men greeted an acquaintance before the start of a fiery meeting between Douglas residents and city officials Wednesday night:
``What're you doing here? You live in Juneau.''
``Yeah. That's over the bridge. Where's your passport?''
Tight-knit doesn't begin to describe Douglas.
Some residents of the former township met at the Douglas library to register their unanimous condemnation of a proposed land swap between the city and the Alaska Mental Health Lands Trust.
A half-dozen city and trust officials and about 70 residents attempted to hash out issues of planning, development density, and a perceived lack of public notification surrounding the swap of 50 acres of the trust's Switzer Creek property for 134 acres of the city's wild Douglas uplands.
Only half the swap is a done deal, said Douglas resident Doug Mertz.
The city has title to the Switzer Creek acreage and has ceded 10 acres of the total 50 to the Alaska National Guard for its new armory. The rest of that parcel is slated for housing development.
``The city could now choose to pay the trust ($900,000) for the Switzer property,'' Mertz said. ``Or it could swap another piece of land or even delete the two-thirds of the Douglas property that is not developable.''
But trust land office Executive Director Steve Planchon objected that all the other parcels the city put up for consideration were not what the trust wanted.
Under questioning about the trust's intentions, Planchon said the process is about a change in ownership, and is not a development plan.
Asked whether the trust would accept the cash instead of the land, Planchon answered with a flat ``yes,'' and was applauded.
``If the city cannot convey the land, the city will pay,'' said city Lands Director Steve Gilbertson.
Assembly member Jim Powell, however, seemed to have a tighter grip on the $900,000. ``We would look at all other options first,'' he said.
The Land Management Plan adopted by the Juneau Assembly in February 1995 identified the Douglas land for disposal.
The city Planning Commission conducted a public hearing on disposal of the Douglas property to the trust in September 1999. A month later, the Douglas Service Area Advisory board reviewed it.
The Douglas audience's questioning nevertheless registered a consensus that residents had not been properly notified.
``The bottom line is nobody until recent weeks knew the scope and effect of the swap,'' Mertz said.
On communication between the city and its citizens, ``we do a pretty good job,'' said Powell. ``But sometimes we miss the mark.''
The city could delay action on the swap, send the deal back to the Planning Commission or tweak the plan itself, he said.
The assembly will begin consideration of the swap when the deal is introduced at its next meeting, on Jan. 24.
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domain: news


text:
An Illinois State Senate committee is expected to vote on a gun control measure today. It's scheduled to hear from some parents whose children died in December’s mass shooting in Newtown, Connecticut. IPR’S Tony Arnold reports.
Three parents from Connecticut talked Sunday in Chicago about banning high capacity magazines. A proposed bill would make magazines that hold more than 10 rounds illegal. Nicole Hockley’s 6-year-old son Dylan was killed in the Newtown school shooting.


text:
Preparation time: 15mins
Cooking time: 20mins marinating, 11mins for pasta
Dietary guidance: v
1. Score a cross in the base of each tomato. Place tomatoes in a large bowl & pour boiling water over them. Drain after 10 seconds, then peel the skin away from the cross.
2. Halve the tomatoes & press halves to squeeze out the seeds & excess juice. Chop tomato flesh roughly, place in a sieve over a bowl & sprinkle with sea salt. Leave to drain for half an hour.
3. Place drained tomatoes, olive oil, vinegar, lemon juice & zest, garlic, chilli & pepper in a bowl and stir. Leave for 20mins so the flavours can combine.
4. Cook spaghetti in rapidly boiling, salted water according to packet instructions. Drain well. Toss through tomatoes with freshly torn basil leaves & serve with freshly shaved Parmigiano Reggiano & a crusty baguette!


text:
Sunderland v MANCHESTER CITY: Kompany set to be recalled
Manchester City's Blumer Elano celebrates scoring his secong goal with team mate Vincent Kompany (right) against West Ham
Mark Hughes reported no new injury concerns after Manchester City's UEFA Cup qualifier against FC Midtjylland as he quickly turns his attention to Sunday's trip to Sunderland.
Hughes' men had to endure extra-time and penalties in Denmark to secure a place
in the UEFA Cup first round last night.
Micah Richards came through the match without any problems having suffered
concussion against West Ham last week, while Hughes will be able to recall Vincent Kompany, who was ineligible for the European qualifier, for the trip to Wearside.
Benjani Mwaruwari and Kelvin Etuhu did not travel to Denmark while Valeri
Bojinov and Darius Vassell are long-term casualties.
TEAM (from): Hart, Schmeichel, Corluka, Richards, Kompany, Dunne, Onuoha,
Ben Haim, Ball, Garrido, Fernandes, Hamann, Ireland, Johnson, Elano, Evans,
Sturridge, Caicedo, Jo.
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text:
Netflix’s path toward becoming a content provider that can grapple with premium TV’s elite took a step forward Tuesday as the video streaming announced a multi-year deal that gives Netflix exclusive rights in the premium pay TV window to first-run feature films from The Weinstein Company, starting in 2016.
Financial terms were not disclosed, but the deal will give Netflix the rights to stream titles from the studio on connected TVs, tablets, smartphones and tablets. Netflix is already the pay TV home to TWC documentaries and foreign films, including 2012 Oscar-winners The Artist (Best Picture) and Undefeated (Best Documentary Feature),as well as to movies released by RADiUS-TWC, a “multi-platform distribution label.”
"Harvey and Bob Weinstein are in a class of their own when it comes to choosing and producing the best films in the world," said Netflix chief content officer Ted Sarandos, in a statement. "They are as innovative in business as they are creative in their storytelling. We look forward to reinventing the pay TV window with the Weinsteins."
"The deal that we've just completed with Netflix is probably the biggest deal in the history of The Weinstein Company and together, we are discussing ways to reinvent the pay TV experience so that the audience can get even more for their money," added Harvey Weinstein, in a statement. "Their enthusiasm for movies of all kinds was the big factor in our choosing Netflix. Moving forward when people see The Weinstein Company name on a movie they know that our pay TV partner is the most significant new force in the entertainment industry - Netflix."
Netflix added 630,000 U.S. streaming subs in the second quarter, extending its domestic total to 29.81 million.

domain: entertainment


text:
(Memphis, Tenn.—June 7, 2022) Cryogenic (frozen) protein structures are central to understanding function and developing drugs. Scientists at St. Jude Children’s Research Hospital have created an algorithm to reveal when freezing the proteins may create ‘artifacts,’ – errors that cause misleading results. The research appeared recently in Angewandte Chemie and highlighted the importance of water networks in protein-ligand interactions. The findings challenge the common view of assuming that well-resolved cryogenic water positions are both precise and accurate.
Ligands are molecules that bind to a receptor protein. When a ligand binds to a protein, the conformation (shape) can change, initiating different types of activity in the cell. Protein-ligand binding and the resulting shape changes are crucial elements to consider during drug development efforts.
“If you only look at the cryogenic data, the information being used for drug discovery has artifacts baked in that you wouldn’t know were there,” said corresponding author Marcus Fischer, Ph.D., St. Jude Departments of Chemical Biology and Therapeutics and Structural Biology. “We’ve developed a way to disentangle those artifacts. Using paired comparisons between cryogenic and room temperatures you can pinpoint parts of the protein that are affected by temperature.”
Researchers often use available protein structures by pulling the information from a database called the Research Collaboratory for Structural Bioinformatics Protein Data Bank. Around 95% of those structures are captured cryogenically, then modeled within the database for ease of use. Drug discoverers rarely look closely at the raw experimental data, which is in the form of an electron density map. Interrogating maps rather than structural models provides an unbiased approach to revealing dynamic features and cryogenic artifacts.
Flipper algorithm highlights important changes
Fischer and his team developed an algorithm, called Flipper, that looks at the raw experimental data in electron density maps. Flipper identifies map peaks (signals) that would otherwise be invisible. These peaks correspond with the parts of proteins from specific residues that have temperature-sensitive conformations. These residues can change the relative preference for one state over another, or ‘flip’ in their density, moving between conformations, which is where the algorithm got its name.
The researchers used this approach to identify residues that respond to temperature changes and to track the residues in a barcode-like system across the entire protein. This enabled scientists to see how residues inside and outside the ligand binding site respond to freezing or warming temperatures.
“With Flipper we can detect small but important changes in protein structures from temperature or other factors,” said first author Timothy Stachowski, Ph.D., St. Jude Chemical Biology and Therapeutics. “It is important to get these details correct early on in the drug discovery process; otherwise, research efforts might be led astray."
Because the temperature and water-network effects influence a vast number of structures, the findings may have a widespread impact on drug development.
A new appreciation for water networks
Armed with their new approach, the researchers conducted a systematic analysis showing the importance of water networks. Water, one of the most crucial and abundant molecules on Earth, plays an active role in the process of freezing conformations. This is particularly true at protein-ligand binding sites.
“This is the first time that we have systematically shown the importance of temperature on water networks for modulating the ligand binding interface, which is where biology happens,” Fischer said. “Water is often ignored in the drug-discovery process, but we’ve shown that in addition to having a profound effect on ligand binding, water also influences binding site residues, capturing them in positions that differ depending on the temperature.”
Flipper and the conformational barcode system that facilitates comparisons of different ligands at different temperatures is freely available to enable other researchers to identify such patterns in their own datasets.
Authors and funding
The study’s other authors are Karlo Lopez, California State University; and Murugendra Vanarotti and Jayaraman Seetharaman of St. Jude.
The study was supported by grants from the National Institutes of Health (1R35GM142772-01, and P30GM133893), the Department of Energy Office of Biological and Environmental Research (KP1607011); an Academic Programs Special Fellowship, and ALSAC, the fundraising and awareness organization of St. Jude.
St. Jude Media Relations Contacts
Desk: (901) 595-0260
Cell: (901) 568-9869
St. Jude Children's Research Hospital
St. Jude Children's Research Hospital is leading the way the world understands, treats and cures childhood cancer and other life-threatening diseases. It is the only National Cancer Institute-designated Comprehensive Cancer Center devoted solely to children. Treatments developed at St. Jude have helped push the overall childhood cancer survival rate from 20% to 80% since the hospital opened more than 60 years ago. St. Jude freely shares the breakthroughs it makes, and every child saved at St. Jude means doctors and scientists worldwide can use that knowledge to save thousands more children. To learn more, visit stjude.org or follow St. Jude on social media at @stjuderesearch.
Method of Research
Subject of Research
Water Networks Repopulate Protein-Ligand Interfaces With Temperature
Article Publication Date

domain: biology


text: I'm always happy to learn more about the use of overtures and anything else pertaining to road shows or any other special limited engagements. Here's one I always forget exists until I pop in a disc: "Spellbound". Overture and Exit Music. Can anyone fill us in on how or why that got picked to have these? Were they played in standard theatrical showings? Are there other "regular" feature films from the 1940s that were given this treatment?


text:
In 1999, Andrew Rotherham was hearing from more than a few people that his career was over. An education analyst at the Progressive Policy Institute, Rotherham had just authored a report, Toward Performance-Based Education Funding, for the 21st Century Schools Project. The report’s recommendations are, in 2008, pretty basic stuff, even in left-leaning circles. But in 1999, before the advent of No Child Left Behind and the cementing of a bipartisan consensus around “results-based learning,” Rotherham’s suggestions, bearing the PPI label, struck many of his fellow Democrats as nothing less than heresy.
Fortunately for Rotherham, the reports of his professional demise were greatly exaggerated. Now co-director of Education Sector, a new education-policy think tank he founded with journalist Thomas Toch, Rotherham is the go-to guy for those looking for serious, cogent analysis of the latest education trends. Rotherham’s irreverent blog Eduwonk has become must-reading inside and outside the education establishment, earning praise from the New Republic as “a very smart blog” for those hoping to separate “the demagogic attacks on NCLB from the serious criticism.” In 2006, Education Week named Eduwonk one of its top-ten most influential education sources.
Eduwonk mixes it up. Some entries are deeply wonkish, others are more accessible to lay readers, and some are just good-natured fun. Rotherham’s “Friday Fish Porn” posts — which feature pictures of various education-types posing with the gilled loot from their aquatic hunting-adventures — are particularly popular. (He’s an avid fly fisherman.) Its philosophy is, in many ways, an outgrowth of what Rotherham was pushing at PPI: The government’s role in k-12 education is necessary and important, but there’s a serious dearth of smart innovation taking place in the public schools. His mission might be broadly summed up as: Let’s find out what works, and let’s do it.
Rotherham hadn’t always planned on becoming an education wonk, but his boyhood proximity to Washington, D.C., infused him with a need, it seems, to involve himself somehow in the bustling policy atmosphere.
He grew up in Reston, Virginia, amid the venture capital firms and crypto-government organizations not far from Dulles Airport, a 40-minute drive west of the nation’s capital. His mother was a teacher; his father, an official in the Office of Management and Budget, who eventually went to work on Capitol Hill. In those days, Rotherham is quick to note, working on the Hill wasn’t something one did for five years in between college and a lucrative lobbying career on K Street. Hill staffers tended to be older, more professional, more apt to stick around for a while, and, not by accident, more collegial. “You knew,” said Rotherham, “that you’d have to work with the guys on the other side of the aisle tomorrow, and the next day, and the day after that. So it was a less partisan place than today, and things actually got done.”
Some of those good, bipartisan feelings seem to have made an impression on Rotherham. He’s a lifelong Democrat, but his ideas don’t always follow those of his party. His 1999 report on performance-based funding, for example, violated several Democratic Party taboos by calling for real school accountability coupled with increased flexibility in school spending. Indeed, in an August 2000 New Republic article, Ryan Lizza noted that “much of the Bush campaign’s education agenda is cribbed from” Rotherham’s report.
Rotherham also put forth a direct and uncompromising position on public-school choice: “Charter schools and magnet schools are now an integral part of the educational landscape.”
He was right. Charter schools are public schools that operate mostly free from the traditional district school-systems and their stifling bureaucracy. They are thus able to experiment with different innovative educational approaches. Some of the highest-performing public schools in urban areas — the KIPP Academies, for example — are charters.
But in 1999, Democratic Party support for charter schools was shaky, despite then-President Bill Clinton’s avowed support. The teachers’ unions — which carry a lot of weight in Democratic politics — didn’t like them, and still don’t, for the most part. The Ohio Federation of Teachers, for example, threatened in April 1999 to sue the Buckeye State over its charter-school law and labeled charter schools the “leading threat” to public schools. (Never mind that charter schools are public schools.) In New York, after the state approved its first eight charter schools in June 1999, union officials, grasping at technicalities, charged that the vote was illegal. Similar opposition occurred across the country.
To Rotherham, however, charter schools offer new hope to poor kids who have been repeatedly failed by the traditional public-school system. He also believes that the extra funding allotted for Title I schools (those that enroll large populations of poor students) should be performance-based, and he wrote as much in the 1999 PPI report. To receive funds, he wrote, “states must demonstrate that they have a plan in place to identify and reconstitute failing schools; are ending social promotion by identifying and helping students in need; and have a standards and assessment plan in place so they can be held accountable for the performance of impoverished students.”
Rotherham studied at Virginia Tech, where he double majored in history and political science. He also has a master’s degree from the University of Virginia, where he’s currently pursuing a Ph.D. in political science. He took his first job in 1993, as a corporate trainer and consultant for Horizons Consulting, straight out of college.
In 1995, Rotherham entered the education sphere. He began work at the Close-Up Foundation, a civics-education group, where he designed curricula and taught civics to high-school students. While there, Rotherham met his wife, Julie, who has worked for NGOs in international aid and education. His next stop was as a policy analyst for the American Association of School Administrators, after which he moved to PPI, and, in 1999, he became an education-policy advisor to President Clinton.
In many ways, it’s a familiar Washington career track: One job in [insert policy area] leads to another, and before you know it, you’ve become an “expert” and defined your life’s work. But Rotherham didn’t stick with education because he was blithely moving along a defined trajectory but because education truly engaged and motivated him — and still does today.
“What does it mean for our social contract, this incredible inequity in educational opportunity?” he asks. And while Rotherham believes in markets and competition (“you have to give people choices”), he is a strong defender of the government’s role in education, mostly because he believes there are “important equities and public interests the federal government needs to protect” and not leave to the market.
In addition to being his passion, education is a safe niche, and a smart one, for Rotherham to occupy. Most people are completely confused about the inner workings of K-12 policy, but they nonetheless care about it because, well, they have kids. And education, as a political issue, never gets stale. It’s so intimately connected with values (what will we teach the future?); it’s such an important facet of economic and social development (how will American companies meet their staffing needs?); and it always has room for improvement (to put it politely).
Rotherham’s astute observations, and his knack for successfully boiling down impenetrable education studies have made him much sought-after. He seems optimistic about the future of our schools, and sees a “shift in how people approach public education” which reflects “much more of a consumer focus across the board.”
“You’re starting to see the beginnings of a parent revolution around the country, as people realize how important education is, how inequitable it is, and start to demand change,” he said.
It’s tough to argue with him. What was taboo in 1999, when Rotherham publicly suggested that Democrats could support standards and choice, is no longer so in 2008. And as values continue to shift, who knows? By 2014, maybe the teachers’ unions will be calling for vouchers. Whatever lies ahead for education, it’s a safe bet that Rotherham will be in the mix.
–Liam Julian is associate writer and editor at the Thomas B. Fordham Institute and a research fellow at Stanford’s Hoover Institution.
(From the Spring 2008 print edition.)
Source: AFF Doublethink Online | James Velasquez
Source: AFF Doublethink Online | Joseph Hammond


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Hezhou (贺州) is a prefecture-level city in the northeast of the Guangxi Zhuang Autonomous Region, People's Republic of China. Hezhou was home to 2,038,700 inhabitants as of the last 2016 estimation whom 1,415,700 lived in the built-up (or metro) area made of Babu and Pinggui urban districts and Zhongshan county largely being urbanized.
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Yep, artificial intelligence and Wikipedia have already met, I fear. Or are the automatons at work human? Diligent cancelists? At any rate, things are starting to happen, awful things reminiscent of noxious chemical reactions.
The other day, I looked up Helsinki Times in Wikipedia. The first paragraph read:
Helsinki Times is the first English language daily online newspaper in Finland providing news about Finland and the world for English-speaking readers resident in the country. A weekly printed edition was issued between 2007 and 2015.https://en.wikipedia.org/wiki/Helsinki_Times (as at 17 May 2023)
That sounded ok, The article went on to tell me that “notable guest columnists include ….” I looked up those I did not know, including Cynthia McKinney.
Wikipedia’s introductory sentence about Cynthia McKinney was:
Cynthia Ann McKinney (born March 17, 1955) is an American politician, academic, and conspiracy theorist [my emphasis].https://en.wikipedia.org/wiki/Cynthia_McKinney (as at 17 May 2023)
Now I have no idea of what views are held by Cynthia McKinney, who is a member of the Democratic Party. Since she has served six terms in the House of Representatives, she must have served her voters well. She is sure to hold various views which you or I may or may not not share, but HONESTLY: Committing character assassination of Cynthia McKinney in the very first sentence of the Wikipedia article about her seems a bit over the top, no? I don’t know what “conspiracy theorist” views she holds, mind you: Wikipedia having rubbished her, I naturally read no further.
Is Wikipedia now a guardian of a modern “Index Librorum Prohibitorum” ( a list of written works condemned as heretical or injurious to the Christian faith by the Catholic Church at the Council of Trent in 1563)?
Who gets to define something as a conspiracy theory? It certainly isn’t anybody I know.
I am told that if you don’t believe the official story about the murder of JFK, you hold a conspiracy theory. I look up Lee Harvey Oswald in Wikipedia. The article is extremely long. It contains no doubts about the matter, no unanswered questions: The man was emotionally screwed, a defector to the USSR and he did it. He killed Kennedy. Alone. Period. In Wikipedia he is damned without a trial.
I read somewhere just the other day that 70% of the US population have doubts about that story; 70% of the US population are “conspiracy theorists”?
What is a conspiracy theory? Firstly, the expression is pejorative. If you hold conspiracy theories, you should get your head examined, and people you know will cross to the other side of the street when they see you. Conspiracy theories tend to 1) question the intentions of powerful institutions — say banks, the CIA, the President, the national health authorities, etc. 2) Their dissemination is deemed a “threat to Democracy”, to “national security”, etc.
It’s usually the mainstream press that gets to attach the bell to the cat, and the social media will immediately follow suit. The mainstream press does not need to pretend to be unbiased, on the contrary. It’s supposed to promulgate political positions. It might encourage debate on some issues – for instance, about the environmental benefits of electric cars – but conspiracy theories are above question, or should I say below question. They are so base, they must not be put on the table. They are simply trampled on.
Encyclopaedias, however, are supposed to hold certain academic, yea, scientific standards. They may present differing views about controversial issues, including the arguments supporting those views, but it is not for the encyclopaedist to make the final judgment unless the arguments on one side are particularly flimsy.
The arguments raising doubts about the official story of the JFK killing are not flimsy. In the last and very brief paragraph about Lee Harvey Oswald, sub-titled “Other investigations and dissenting theories” those arguments are, however, not presented. A couple of films are listed, presumably to lengthen the paragraph. Remember Oliver Stone’s film JFK? A rather compelling story, no? Too compelling, it would seem, because it is not among the films listed.
The JFK case was a long time ago, and principal players in that drama are long gone. But some lasting damage has been done: You and I know that we cannot believe everything we are told by presidents, government agencies and corporate spokespersons even though they earnestly look you straight in the eye from the TV screen. Had the US authorities not put so much effort into suppressing the “dissenting theories”, the damage would have been far greater.
And now we can no longer trust the intentions of Wikipedia. Wikipedia is, or rather was, our encyclopedia. We made it. Hundreds and thousands of us contributed painstakingly to its remarkable growth. True, we always knew that in the heat of a scuffle, some articles would be skewed. Who can blame a writer from an occupied state who is less than objective about the occupying country! However, since we all had access, we could edit, correct, and view the article’s history. We still can, of course, but with artificial intelligence, it’s a losing battle, I fear.
Today, I came across, once again, an important and well-sourced article in the Grayzone. Articles in the Grayzone tend to be a bit tedious, as they seek to adhere strictly to the source. They are not colourful, ironic or full of beautiful metaphors. They are simply dull, yet, sometimes extremely interesting. I was sure the Grayzone article satisfied journalistic and even scientific standards, so I gave Wikipedia a new chance. This is what I got by way of an introductory paragraph:
The Grayzone is an American far-left news website and blog founded and edited by American journalist Max Blumenthal. The website, initially founded as The Grayzone Project, was affiliated with AlterNet before becoming independent in early 2018. A fringe website, it is known for misleading reporting and sympathetic coverage of authoritarian regimes The Grayzone has denied human rights abuses against Uyghurs, promulgated conspiracy theories about Venezuela, Xinjiang, Syria and other regions, and promoted pro-Russian propaganda during the Russian invasion of Ukraine. The Grayzone has been described by Commentary as a propaganda shop devoted to pushing pro-Assad, pro-Maduro, pro-Putin, and pro-Hamas narratives. [My highlights.]https://en.wikipedia.org/wiki/The_Grayzone (as at 17 May 2023)
Wow! Kill, kill, kill. Is it really no longer possible to simply disagree with content? Does it have to be savaged?
Wkipedia appears to be rapidly descending into an artificial intelligence Hades from which there will probably be no return, unless the damage done is the work of diligent cancelist humans.
On the other hand, GPT chatbot is basically the child of Silicon Valley, which is basically affiliated with the Democratic Party establishment. So whether the automatons at work are digital or human, the ongoing editing of Wikipedia appears to bear the imprint of cancelist Dems.


Hello Folks! I recently had a mishap happen to while pumping gas. A young lady at the pump next to me decided to back up without looking behind her and proceeded to back into me. I have a deep scuff that I am repairing. I have the bumper cover off. I sanded down the imperfection and used a little SEM Bumper Bite to straighten the small area of only about 2 inch diameter. My question is what are my next steps to ensure a long lasting repair. In the past I would spray a little SPI epoxy over the repair area, let it dry, blend the basecoat, then re-clear the entire bumper cover. Never had a problem before but am I missing anything? Any recommendations? Thanks!


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You are here
Barista Bash 003 Recap
Thanks to everyone who came out for the Prima Coffee Barista Bash 003 hosted by Java Brewing Company on Friday night! There was a great turn out with both new and familiar faces in attendance.
A special thanks goes out to the folks lending their talents for the event. Kenny and Darren of Sunergos Coffee were kind enough to offer up their skills for the latte art classes and they did a great job teaching us novices. Sarah Welder and Sarah Buker of Java gave an excellent demonstration on brewing with the french press method. Phil Revell of Quills Coffee and Chris Heiniger of Sunergos brewed up some delicious coffee while demonstrating both the V60 and Chemex pour over methods. And our very own Matt Galyon and friend of Prima Brian Moats finished up the brewing demos with the Yama Syphon method, which of course drew an intrigued crowd! And to Kenny (winner of the Barista Bash 002 latte art competition), Matt Argo of The Anchorage Cafe, and Nathan Quillo, owner of Quills, for judging throughout the night!
Great coffee was to be had throughout the night, whether brewed or pulled. Mike Safai of Safai Coffee & Tea roasted several pounds of tasty coffees and donated them just for the Bash. Chris Cockrell of La Grange Coffee Roasters provided some delicious coffees as usual at the Bashes, and we are always grateful. And some of the folks from Alliance World Coffees made the trip down from Muncie to hang out and compete in the latte art competition, and donated some coffee as well to the Bash. You gotta love the coffee community!
Congratulations to the winners of the night! Josh Monroe of Java won the raffle prize for the night, which included a $10 gift certificate to Prima Coffee, a sweet Barista Magazine shirt, and a one year membership to the Barista Guild of America. Barista Bash 001 winner Chris Heiniger came in second in the latte art competition this time around, winning a Prima Coffee shirt, subscription to Barista Magazine, and $10 gift certificate. Sarah Reynolds of Alliance came down and became the first non Louisvillian to win the competition and surely made Muncie proud! The first place prizes included a Prima shirt, a Barista Magazine subscription, a $25 gift certificate to Prima Coffee, and a Prima Coffee tamper.
Thanks to Chris Lavenson and Stephen Ripley for being so accomodating and for being great hosts, as well as to the other Java baristas who worked so hard throughout the night. Thanks to Cameron Deeb for emceeing the events, and to Michelle Jones of Consuming Louisville for helping spread the word. The photos you see on the blog were provided by Brian Moats. Nice work! To everyone who came out and got excited about coffee and its awesomeness, we really appreciate your support and for supporting these great baristas who prepare coffee and espresso with excellence every day.
Until next time!


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Chemical Manufacturer to pay $93,900 for EPCRA violations
Per USEPA News Release 19 July 2012
Company Fails to Properly Report Chemical Storage & Useage
A chemical producer faces an EPA fine of $93,900 for failing to report the use and storage of hazardous chemicals at its Fairfield, Conn. facility, in violation of the federal right-to-know law.
According to a recent EPA complaint, the company, 5N Plus, Inc., violated the Emergency Planning and Community Right to Know Act (EPCRA) by failing to report hazardous chemical inventory information, known as Tier II reports, to the fire department, and the local and state emergency responders. The company also failed to report the use and potential release of lead and selenium to the state and federal Toxic Release Inventory, a national database of toxic chemical use available to the public.
During a June 2011 inspection of the facility, EPA determined that 5N Plus had failed to follow the reporting requirements by failing to include gallium trichloride (an extremely hazardous substance) in its inventory of hazardous chemicals for 2010, and by failing to submit Tier II reports for reporting years 2008 and 2009 for chlorine gas, lead and gallium trichloride. Following further review, EPA also determined that the company had failed to submit accurate Toxic Release Inventory (TRI) reports for lead in 2008 and 2009, and for selenium in 2010.
After the two inspections, a release of chlorine gas at the facility resulted in area-wide evacuations and worker exposure to chlorine gas. Subsequent to the release, the company moved its gallium trichloride manufacture to another facility.
The proposed penalty includes $40,500 for failure to file Tier II forms for 2008, 2009 and 2010 and $53,400 for failure to file TRI forms for reporting years 2008, 2009 and 2010.
How do you prevent that from happening to you?
The first step in preventing unwanted enforcement action and penalties is to fully understand what chemicals are on-site, what physical states that they are present in, how much you have and how they are used and stored at your facility. The next critical step is understanding what laws and regulations are applicable to these hazardous chemicals. Many of the USEPA regulations are triggered by the type and amount of chemical used and/or stored at a facility.
It is also almost impossible to prepare emergency response plans and procedures without understanding what is present at your facility and how it might impact human health and the environment if it were accidently released.
Did you Know?
Safetec can help you get the answers you need. Ask us about our chemical inventory services, our chemical compliance management and other products and services that can assist you in achieving compliance not only with EPCRA, but also with many OSHA and EPA regulations.


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Fiona had never seen THE KID — I have been slowly trying to raise her appreciation of Chaplin, a decades-long project that reached its apogee with A DOG’S LIFE, which she found delightful. She also got quite a bit of pleasure out of MODERN TIMES and THE GREAT DICTATOR. Oh, and the monkeys in THE CIRCUS had her on the floor begging for mercy, tears rolling down her face, sideways (because she was on the floor). She’ll always be a Keaton girl, which is fine, but I think you’re missing out on something if you don’t check out Chaplin.
THE KID seemed like a good bet because Chaplin is bolstered by a strong co-star. Fiona liked the dog in A DOG’S LIFE and Edna Purviance even gets to be funny in that one. And Fiona likes Paulette Goddard on principle. So I was staking everything on Jackie Coogan and on Chaplin’s chemistry with him. It worked!
Things didn’t start too great, as the intertitle “A picture with a smile — and perhaps, a tear,” provoked the response “Oh fuck off,” which Chaplin had neglected to list in his catalogue of responses. If he had written “a smile — and perhaps a tear — or possibly an Oh Fuck Off” he would have been bang on the money.
But once Charlie gets landed with an unwanted baby, her attitude changed. Chaplin can be brutally UNsentimental, which only Walter Kerr in his majestic The Silent Clowns really acknowledges. Here, the comedy comes from the defenseless baby becoming a threat. Like Stevenson’s The Bottle Imp, or Tex Avery’s Droopy, you can’t get rid of it. When Chaplin opens a drain and briefly looks thoughtful, Fiona practically screamed in shock and then laughed in relief. “No, I can’t really do THAT,” Chaplin seems to think at us, as he closes the drain again, baby still in his arms.
The baby then scene-changes into Jackie Coogan, and we’re pretty much home free. The little blighter is adorable and hilarious — Chaplin has schooled him in every move, you think, until you see his astonishing crying scene, which comes straight from the heart and can’t be faked or produced by imitation.
Chaplin (and his gag-writers) manages the action of scenes marvelously, developing situations into crises and finding unexpected ways to solve them. A lot of the comedy follows the baby problem pattern, turning a helpless and appealing infant into a deadly threat. The kid gets in a fight and a bulbous pugilist turns out to be the opponents brother. He’s going to pummel Charlie if his brother loses the fight. Charlie is now trying to sabotage his adopted son’s efforts. Or when Charlie, a door-to-door glazier, feels the watchful eye of a policeman on him — now the kid, suspected of throwing stones, becomes an incriminating item. Charlie must deny the association, gently kicking Jackie away with his foot. A father rejecting his son, writes Kerr, is monstrous. But here, because of the crafting of the situation, it’s hilarious. The kid is oblivious, uncomprehending, so we’re not tempted to emote at the wrong point. The man in trouble is the father.
Chaplin still wasn’t so good at developing the whole arc of a story, and this remained his biggest difficulty. Starting out with more of a plan might have helped him, but then you look at the talkies… This leads him to the heavenly dream sequence, a heavy slice of whimsy — pointless, unfunny and positioned to paste over the fact that the plot is going to resolve itself happily without the protagonist doing anything. It’s exactly like the massive ballet in AN AMERICAN IN PARIS, only that’s entertaining in its own right. Chaplin’s paradise is more boring than Dante’s, and seems longer. “What has this got to do with anything?” asked Fiona.
But sooner than you think, the ending comes, and the film seems sort of perfect again. The good bits are sublime. The one bad bit disappears from memory like… like a dream upon awaking.
Criterion’s Blu-ray makes the film look like it was shot yesterday. Uncanny. My images come from the earlier DVD.