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Last October, the State of Rhode Island Department of Health ordered Dr. Stephen Skoly Jr. to close his 11-person dental and surgical practice until he complied with Rhode Island's COVID-19 vaccine mandate. Skoly is now seeking declaratory and injunctive relief against enforcement of the compliance order that resulted in shutting down his practice.
Skoly, who claims he's not an antivaxxer, has a history of Bell's palsy paralysis and opted not to get vaccinated due to the uncertainty of the risk of palsy recurrence, according to documents filed in the U.S. District Court for the District of Rhode Island. Furthermore, the complaint states that Skoly has natural immunity because he contracted COVID-19 in December 2020, and his risk to a vulnerable patient is "at worst, identical to the risk posed by a physician whose COVID-19 immunity is achieved through vaccination."
The complaint, filed against Gov. Daniel McKee and interim health department director Dr. James McDonald, calls the decision to suspend Skoly's practice "arbitrary and irrational." Skoly is also seeking an injunction to allow him to reopen his practice again.
"The Rhode Island Department of Health has mysteriously refused to follow the science when it comes to natural immunity," Mark Chenoweth, executive director and general counsel of the nonpartisan nonprofit New Civil Liberties Alliance, who is representing Skoly, said in a press release. "Governor McKee has no valid basis to bar Dr. Skoly from performing oral surgery, as it would be perfectly safe."
Alleged unfair treatment
The complaint claims that Skoly wants to be treated like other healthcare professionals who have been granted medical and religious exemptions and remain able to care for even the most vulnerable patients. After the state ordered him to stop seeing patients in October, Skoly requested a medical exemption. However, it was denied because Rhode Island did not recognize the risk of Bell's palsy recurrence as an acceptable condition for a medical exemption, according to the complaint.
Those who receive exemptions can continue to practice their professions, including treating vulnerable patients, if they adhere to precautions such as masking. Despite agreeing to comply with safety measures, including wearing an N95 mask when treating patients, Skoly cannot see patients, according to the suit.
"Under these circumstances, barring Dr. Skoly from his profession is an irrational and unfair application of the regulation," according to the complaint.
Furthermore, Skoly claims that his inability to practice has had a detrimental effect on the approximately 800 patients treated monthly at his practice, as well as patients he treats at the state psychiatric hospital and state prison. Additionally, this is an even greater hardship to state residents because there are few practicing oral and maxillofacial surgeons in the state, according to the complaint.
The clinician stated that he can get most of his staff together and begin treating patients again within 48 hours if the court rules in his favor.
"In any event, vulnerable people have had access to the vaccine for a year, and anyone who wants to get the vaccine may do so," according to the complaint. "There is no need to force the vaccine upon Dr. Skoly, particularly considering his naturally acquired immunity."
Vaccine mandates and organized dentistry
The issue of mandatory COVID-19 vaccines has been a hot-button topic, and some dental healthcare professionals have weighed in on the matter. In September, a dozen oral health organizations, including the American Dental Hygienists' Association (ADHA), announced in a statement that COVID-19 vaccinations should be mandatory for oral healthcare workers, students, and residents.
The ADA was absent from the call in September to require COVID-19 vaccinations. Instead, the ADA has recommended dentistry receive vaccines but has stopped short of saying they should be required.
A study published online in January in the Journal of Dental Sciences revealed that many practicing dentists worldwide remain reluctant to receive vaccinations for COVID-19.
Copyright © 2022 DrBicuspid.com


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Yiamas Gastro Bar is a modern greek restaurant with European cusine · Wine Bar in Kalamata, Messinia.
Yiamas Gastro Bar is a new warm relationship and with the most welcoming people, it is the first restaurant in the city with daily music by djs and with quest appearances by famous singers and bands. The kitchen serves hot food that mixes creativity and aesthetics
The search of a good seafood in Kalamata has been so far an endless journey! The “Atherina” is now your choice!
The search of a good seafood in Kalamata has been so far an endless journey!
The Elite City Resort based on the needs of their visitors and locals has created a small, cozy and friendly place just right where the sea waves are.
Its name is ATHERINA, which is a female name, elegant and will win you right away. The importance of this project is larger than its first view.
ATHERINA is here to show us that really good food can be found at affordable prices in style and the sense of a relaxed summer tavern with A ‘quality seafood. The ingredients are fresh and well chosen and of course the recipes are Greek. The pan and the grill are definitely in good hands !!
ATHERINA awaits for you either at lunchtime or for dinner on the Elite City Resort terrace right next to the waves and promise to offer you a different breeze to your summer.
“ΕΥ ΖΗΝ” Restaurant for distinct flavors and unique dishes.
Elite City Resort at Kalamata, presents the “EΥ ZHN” Restaurant that manages to combine the flavor with elegance and luxury. In our restaurant, which recently completed the process of development and implementation of Food Safety Management System HACCP certified in accordance with DIN EN ISO 22000 : 2005 HACCP by internationally recognized Certification Body TÜV HELLAS (TÜV NORD Group) A.E., you will taste dishes created by renowned chefs, with imagination in decoration and taste combined with Greek and International cuisine, made from the freshest local ingredients. The surrounding area of the restaurant, along with the porcelain cutlery and crystal glasses, in conjunction with unique flavors, transform your lunch or dinner at a special feast of taste and enjoyment.
Elite Aqua Club, the ultimate choice for entertainment and event organization or party morning and night.
Elite City Resort, as part of its effort to let its guests satisfied and happy, created Elite Aqua Club. This is a club that consists of the pool bar and pool restaurant, around the pool area with modern decor and luxury, allowing the guests to enjoy a drink or a cocktail or taste a fresh snack or a light meal, in a relaxing and renewal atmosphere.
It is open all day, offering guests sun loungers and umbrellas, pool towels, personalized treatment and first-class service. Elite Aqua Club also recently completed the process of development and implementation of Food Safety Management System HACCP certified in accordance with DIN EN ISO 22000 : 2005 HACCP by internationally recognized Certification Body TÜV HELLAS (TÜV NORD Group) A.E, and is also available for organizing events or parties. During the summer months, every Thursday a D.J. at the pool bar, converts your vacation in absolute fun. The pool restaurant serves throughout the day delicacies or snacks, allowing you to savor small dishes of Greek and International cuisine. During lunch and dinner, the atmosphere and the mood change completely, as the stylish and well treated outdoor area conform to the colors of the pool and the sea and allow you to enjoy your meal with a sense of relaxation and enjoyment.

domain: food


Ahmed Johnson Interview, Christian’s Return, & New WWE Signing
Here is the link to an Ahmed Johnson interview with The PWKGW Network. Went over 70 minutes and he discusses Owen Hart, Goldust, wrestling today, his dream match in today’s WWE, lots of stories from his career, plus a comment on nelson mandela and what celeb he would love to beat up. You can check it out by clicking here The interview starts at the 30 minute mark.
For those that missed it, WWE announced on Smackdown that Christian would be presenting the “This is Awesome” Moment of the Year award.
Staffslive in the UK is report that WWE has given a developmental deal to former Port Vale goalkeeper Stuart Tomlinson. He met with WWE officials during the last UK tour. He’s 28 years old and just retired due to a knee injury. You can read their report by clicking here.


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Bulgaria's Ataka Withdraws Proposal for Belene NPP debate
Bulgaria's nationalist Ataka party withdrew its proposal for discussing the restart of the Belene nuclear power plant project.
The proposal was motioned by the nationalists, who used the parliamentary procedure allowing opposition parties to initiate debates, without a mandatory voting.
Ataka was proposing the cancellation of the 2012 decision of Parliament to stop the construction of the power plant.
The former interior minister Rumen Petkov, who is also a member of recent socialist breakaway formation ABV, claims Ataka withdrew their motion because of "some bargain with BSP". He said there were several options for restarting the Belene project, but the fact that the matter is not discussed in Parliament means that there was some tacit agreement.
The restarting of the Belene project was one of the main election promises of the Socialists.
- » Unit 6 of Bulgaria’s Kozloduy NPP Shuts Down for Planned Annual Overhaul
- » Bulgaria Still Pinning Hopes on Gas Hub Project with Russia
- » Bulgaria 'Offers Azerbaijan Energy Cooperation Package'
- » Mining Industry Accounts for 5% of Bulgaria’s GDP – Energy Minister
- » Price of Natural Gas in Bulgaria May Drop by over 13.6% as of October
- » Watchdog OKs Agreement between Bulgaria’s National Power Co, ContourGlobal Maritsa East 3 TPP

domain: news


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A trio of St. Cloud State University Chemistry and Biochemistry students attended a national conference in Philadelphia, Pennsylvania in early April to present research they conducted and network with scientists from around the country.
Students Ujala Chawla, Wengelawit Molla, and Jharef Tecsihua Tamariz represented St. Cloud State at the 2022 American Society of Biochemistry and Molecular Biology (ASBMB) conference on April 2-5. The students joined thousands of scientists from multiple disciplines to present their latest findings, participate in lectures and workshops, and network with all in attendance.
During the student poster competition, Molla presented research that was compiled along with St. Cloud State Assistant Professor of Chemistry, Dr. Nathan Bruender. Poster competition included students presenting research to peers and judges before being judged by a panel of undergraduate faculty members, principal investigators, postdoctoral fellows, and industry and government professionals.
The trio of students are all part of St. Cloud State’s Biochemistry and Molecular Biology Club, a student chapter of ASBMB and a group of students who share educational experiences and explore on- and off-campus opportunities. Learn more about the club offerings and student opportunities within the Department of Chemistry and Biochemistry.

domain: chemistry


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I had the privilege to meet up with the Palestinian-Irish playwright Hannah Khalil this week in London a day before the opening of her latest production ‘Scenes from 68 Years’. A project that has been in development for over five years, it went through several stages to secure all the necessary funding and for the script to be artistically developed to a tee. It is being produced by Sandpit Arts.
Here she tells me more about the inspiration behind her latest theatrical creation, her hopes for the play, the choice of cast, intended audience and the use of that signature black humour in tackling the very complex story of Palestine and its people.
Whether you are one of Khalil’s avid followers – who frequently attend her plays or listen in to her productions on BBC Radio 4 – or new to her work, this will be a must attend for Londoners. It promises to be the freshest, liveliest and most dynamic theatrical treatment to date that looks sharply yet lovingly into the lives of Palestinians whose historical journey has seen them live under and survive a brutal occupation over the passage of 68 years.
For the award-winning Khalil, ‘Scenes from 68 Years’ is her fourth major play being put on a big London stage, following the earlier works of ‘Leaving Home’ (at King’s Head Theatre), ‘The Unofficial Guide’ (at Battersea Arts Centre) and ‘Plan D’ (at Tristan Bates Theatre). This latest production will also be the second project to be directed by Chris White, who is not just the playwright’s artistic partner but also her husband of eight years.
One unusual element for the audience is that one of the cast members will be performing every night via Skype from a base in Nazareth. The Palestinian Maisa Abd Elhad will be making an online debut as she interacts with the other six also highly esteemed actors. Tackling the challenge of completing 30-plus scenes and 50-plus characters in 100 minutes, the other cast members are: Yasen Atour, Taghrid Choucair-Vizoso, Janine Harouni, Pinar Ogun, Mateo Oxley and Peter Polycarpou.
Nahla: Can you give me an example of one of the scenes, your inspiration and the artistic approach you have taken in creating the play.
Khalil: “For all the scenes, I wanted to set up a scenario where the audience think they know the version of the Arab world and Palestine that is being portrayed; but that, by the end of each scene, their expectations have been undercut. That is what I am trying to do. Also, bar none, these scenes are based on real stories that have been given to me by somebody or based on research and or anecdotal evidence.
“One example scene is of a little girl who is all covered up in bandages and she calls on her father for help because she is feeling uncomfortable. So the audience presume that she has been in some kind of a horrible accident or something to do with the war. But the end of the scene, you realise that actually her father is a doctor who in 1948 was helping resistance fighters learn first aid and that the girl was being used as a test dummy.
“The writing of the scenes was in fact very quick and easy but the devil of the play is getting those scenes that are seemingly unlinked into a framework and order that gives a dramatic satisfaction, without having one character whose journey you are following through. It is about getting a form whereby you have a moment of climax where you need to have it and a moment of pathos where you need to have it also.”
Nahla: Can you tell me more about the characters in the play?
Khalil: “Only two characters are named in the script. One is Rula and the other one is Nadia. Otherwise, everyone is called as ‘man’, ‘soldier’, ‘friendly soldier’, ‘woman’, ‘daughter’, ‘mother’. They are all non-specific, because the idea is to give a sense of what it is like to live under occupation and not just necessarily for the Palestinians but also for the Israelis as well, although they don’t’ get as much of a look in.
“There are in fact two family scenes which are set up in counterpoint to one another. In one there is a table in an Israeli household with a teenage girl and her parents and in the second a Palestinian household with two teenage boys and their mother. They were written as a pair of scenes and I hope they resonate for the audience, to see the similarities between them and especially regarding the wants and needs of young people.”
Nahla: Being half-Palestinian, do you feel an artistic responsibility to tackle the subject of Palestine?
Khalil: “In my twenties when I first started writing plays, I avoided writing about Palestine like the plague because I was very scared of it. Everyone still asks me about the situation in Palestine and almost wanting me to be a spokesperson. But I didn’t feel like I had the knowledge. I felt very uncomfortable about it.
“But later on I met Chris White, the man who is now my husband, who gently encouraged me to explore it by offering books, seminars and other things. So suddenly I did loads and loads of work and research and was fascinated to learn the history of Palestine and now I feel really equipped to write about it.
“It is possible that some Palestinians might watch this play and think that here is an opportunity to bang the drum for Palestine and that I am not doing it hard enough. But my argument will always be that I am not actually writing for people who know what is going on. I am writing for a middle class English person who goes to the theatre and is terrified and doesn’t’ want to engage with Palestine because it is too much.
“But, of course, there is so much to it and you may be afraid to go there because you feel you have to spend too much time and effort to make sense of the situation and understand it, so let’s ignore it. But what I really hope this play does for such an audience member is to make them laugh. I have tried to make this a funny play so that anyone watching, please laugh!”
Nahla: Are the scenes chronological and do you refer to any particular historical passage?
Khalil: “The scenes are not chronological and I consciously don’t refer to things like BDS but the Nakba is referred to. Every scene has a date at the top of it but this was done more for the director and the actors so they understand the time and place of that scene, whether it is pre-second intifada or post and what has happened around it.
“But for the audience, I don’t want them to be afraid for not knowing those details. Actually, the point I am making is whether it is 1949 or whether 2015, the situation for the Palestinians is the same. They are still in the same position and nothing has changed or hasn’t changed enough! So the dates are just to help the audience locate the scenes, as there are so many different places and we can’t be too specific.”
Nahla: Can you tell me more about the use of humour in the script? Does humour defuse the difficulty and complexity of the subject?
Khalil: “I don’t’ set out trying to be funny but I do set out to find the truth. I think because I am half-Palestinian and half-Irish, they are both backgrounds that find humour from bleakness. I am really inspired by Samuel Beckett and that whole Beckettian way of existence and being that is sadly reminiscent of the Palestinian condition; that of being in stasis but having to remain good humoured and having that dreaded hope that keeps you going.
“Theatre is also different from documentaries, hard news or even feature films, in that theatre is for metaphor, it is for symbolism, it is for the live experience and the immediacy of that live experience… and that is why I am so excited for having Maisa in Palestine.
“What I am hoping that will do is to make people think: ‘Hold on a minute, are we sat here watching a play and it is all pretend; but, that actually, this is a play about Palestine and there is someone who is actually there now, whose life is affected by all the things that are being described in this play?’”
Nahla: What about the cast, rehearsals and preparations for the big day? And what is it like to work with director Chris White?
Khalil: “Part of the reason why I started writing plays about Palestine was not just to explore it for myself but also to try and write great roles for Arab actors or actors of colour, because there are just not those parts for them or not good ones. How many times am I hearing my friends who are Arab say: ‘Yes, I have my hijab on for an audition for a crying mother.’ It is really reductive. So I want to write great and interesting parts and unusual parts, which are all in this play. Of the cast, four are Arab actors (Maisa, Taghrid, Yasen and Janine) and Peter who is Cypriot, Mateo who is English and Pinar who is Turkish.
“What is also so humbling and gratifying is that when I last went to the set, I started to cry and got really emotional, partly because they were all doing such a great job. But it wasn’t just about the cast but the whole production team, including the production manager, stage manager, sound designer, our PR and producer. They all believe in the play and are working hard to try to bring it to life. It also means that I have gone to buy waterproof mascara, cause I’ll be needing it!
“Chris is the one who has always encouraged me to explore my Palestinian roots and he has read every single thing I have ever written. He knows me very well obviously and understands my family and background. So, it is okay for me not to be in the rehearsal room, because when I go and see a run, I feel that, yes, of course, it is exactly how I imagined it would be because he knows.”
Nahla: What are your hopes for this play?
Khalil: “Of course I want an Arab audience to come and watch the play and like it. But what I really would love is if someone to come up to me and say: ‘That is totally not what I thought this play would be. It has made me think that I quite like to know more about Palestine and about Palestinian people, because I don’t think they are what I thought.’ If a couple of people go out of the play with that in their head, then hallelujah, I’ve done a good job!
“I would love it if the play has further life because there is a lot you can do with it depending on budget and location. You can have it with a minimum of six actors with little set or with 30 actors on the main stage of the Olivier with loads of money and different sets for every scene. So it would be exciting to think that other people might be inspired to do it their way.
“But for me, success looks like, wow, it is going to be on tomorrow! That it is finally happening! We have an amazing cast and an amazing crew and I just feel completely blessed and privileged for them to be doing my work.”
Scenes from 68 Years is on at The Arcola Theatre from 6-30 April, 2016.
For more information on Sandpit Arts: http://www.sandpitproductions.com/
Note: This article was first published circa April 2016

domain: artistic


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Do you like Ross Marquand?
Ross Marquand BiographyA native Coloradan, Ross Marquand received his BFA in Theatre from the University of Colorado at Boulder. Shortly thereafter, he moved to Los Angeles and quickly garnered attention in several film and television projects. Marquand's breakout role came on AMC's "The Walking Dead," portraying Aaron. Marquand also played the late Paul Newman on "Mad Men." An accomplished voiceover actor, Ross has provided his unique vocal talents for countless projects. He is known for impersonating a plethora of celebrities including Harrison Ford, Brad Pitt, Kevin Spacey, Matthew McConaughey and over 50 others. His impression work was noted by "Impress Me" creator Ben Shelton, who developed the show with Marquand and fellow impressionist Jim Meskimen. Marquand currently resides in Los Angeles.
Ross Marquand Wiki
- In Fort Collins, Colorado, USA
- Movie/TV Credits:
- First Appeared:
- In the movie A Lonely Place for Dying 2009-01-01
- Latest Project:
- Movie Camera Trap 2015-08-25
Ross Marquand Comments
Ross Marquand Social
Who is Ross Marquand?
Ross Marquand Filmography & Movies
|Movie||Spare Change||Mr. Hartman||2015-02-14|
|Movie||Down and Dangerous||Henry Langlois||2014-02-14|
|Movie||Amira & Sam||Greg||2014-05-30|
|Series||Dog With a Blog||Talking Dog||2012-10-12|
|Series||The Walking Dead||Aaron||2010-10-31|
|Movie||A Lonely Place for Dying||Nikolai Dzerzhinsky||2009-01-01|

domain: entertainment


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The moSwords Mod adds a lot of new swords to the game.
These new swords vary from the pretty normal ones, that acts like any sword you’d already find in Minecraft, to the cool ones with special powers, to the goofy ones like the fish and carrot sword, that can actually be eaten.
The current version of the mod adds 42 various swords and items, so there is plenty of new content.
Each element has a sword, so there is a fire sword that sets enemies ablaze, a frost sword that slows them down, a wind sword, that when right clicking, will unleash the power of the heavens upon your foes, with deadly lightning strikes (using this in pigs turns them into zombie pigmen), and finally a earth sword.
Furthermore, there is plenty of custom swords included, like paper-swords, bat-swords, pirate-swords, legendary sword, there is even a +1600 attack damage sword.
But that is not all, this mod also has a goofy side with all the eatable swords such as the carrot sword, the melon sword, the sugarcane sword and much more. And yes, right clicking with this sword equipped will make you eat it (only works when the player is hungry).
Important: this mod requires Minecraft Forge.
Here are some screenshots of all the swords and items added by this mod:
How to install moSwords Mod for Minecraft:
- Download the mod from below.
- If you don’t have Forge, then download and install Forge for Minecraft (remember to select the “Forge” profile in the Minecraft launcher).
- Open your minecraft folder (in Windows: Start -> Run -> “%appdata%\.minecraft”).
- Copy the mod files you downloaded to the “mods” folder found inside the .minecraft folder.
- Enjoy your new swords, and try not to eat them all!

domain: hobby


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- Solid Wood w/Clear Finish
- Height Adjustable Easel
- Accepts Stick Chalk & Wet Erase Markers
Chalkboard on Easel Combo With Natural Wood Construction
This chalkboard on easel combo offers one-stop shopping in one convenient package. Display welcome messages or sales promotions to visitors or customers just about anywhere, thanks to the portable nature of the stand. The chalkboard on easel combo can be strategically placed where no wall mounted message board can! The chalkboard features a black engineered writing surface that accepts not only traditional stick chalk, but also wet erase markers like colored liquid chalks. The board is handsomely framed with solid wood, making it a great match to the wooden easel. You can adjust the easel's viewing height easily while the top clamp holds your board securely in place. Buy our easel combo for your business or retail store!
|Overall Width x Height x Depth||26.0" x 67.5" x 45.0"|
|Placement Style||Floor Standing|
|Loading or Door Style||Open Face|
|Features||Tilting, Adjustable Height|
|Support Bar Height Range, (inches)||14.0, 42.0|
|Bulletin Surface Color||Black|
|Type||Wet Erase, Liquid Chalk, Chalkboard|
|Common Size||26" x 18"|
Browse reviews from customers who have already purchased this product.
This product has not been reviewed yet. Be the first.
WARNING: This product can expose you to Titanium Dioxide, which is known to the State of California to cause Cancer. For more information go to www.p65warnings.ca.gov.


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Here's All You Need To Know About Shahid's Fiancee, Mira Rajput!
According to a Bombay Times report, Haider actor Shahid Kapoor is all set to marry Delhi girl Mira Rajput in December, 2015. The couple reportedly got engaged on January 14, 2015, the report stated. A while ago, Shahid had said that he wanted to get married to someone who doesn't belong to the film industry as it will help him in seeing life from a different perspective. Let's know more about the girl who managed to steal Shahid's heart.
Shahid dated Kareena Kapoor for more than three years, but later the two shocked their fans as they parted ways. Shahid was also linked up with Priyanka Chopra and Vidya Balan. According to a Bombay Times report, Shahid's bride-to-be is a third-year English (Hons) student at LSR and did her schooling from Vasant Valley School. Apparently, Shahid met Mira through the religious group, Radha Soami Satsang Beas.
According to a Bombay Times report, Shahid and his father, Pankaj Kapur are ardent followers of the group where he met Mira. Shahid and Mira have been lying low about the news of their wedding and have been avoiding the media. There have also been reports about Shahid's dad visiting Mira's Chhatarpur house to meet her parents a few days back. In the past, there were reports that claimed that his father was looking for a bride for him from Punjab. However, Shahid cleared the air about the rumours. On being asked about the reports, Shahid had said, "I don't know why people publish such stories. I was in Kashmir shooting for a film and my father was busy with his work. He is not looking for a bride."
When there were reports about the possibility of an arranged marriage, Shahid had refuted saying that he will find his own bride. In an interview, Shahid had said, "I will search for a bride and not my father. He selected his life partner and so will I. My father goes to Punjab to meet our relatives there and he has his spiritual guru in Punjab and that's about it," claimed Shahid.
According to a report on Bollywoodlife.com, Mira has done an internship with the United Nations. The report also states that she is a fan of several singers from the West like Avril Lavigne, Beyonce, Demi Lovato. Since, Shahid also has an ear for music and plays the DJ in his house parties, it seems that the two have lot in common to bond over.

domain: celebrity


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22 year Old MA Journalism student from Liverpool. Mostly enjoy writing and making things related to music, but giving out advice I've learnt over the years is also a fun part of what I do.
Moving away from the place you call home is a difficult transition for many of us and it’s a transition that can often leave us feeling isolated and uncomfortable in our day-to-day lives.
I recall in my first year, I suffered with homesickness quite a lot. This feeling persisted through my second and third years also, but having been in Lincoln for over three years now. I’m happy to say the feeling is, for the most part, becoming a distant memory. I still miss home, but that feeling of ‘homesickness’ has gone away.
Within the first month of arriving at university I was overwhelmed with some of the most conflicting feelings of both extreme happiness, extreme sadness and also a niggling thought that the sadness I was feeling was unjustified or selfish.
With all these new people and new opportunities surrounding me, and with everyone else appearing okay and happy. I asked myself why wasn’t I feeling the same and why should I want to return home to my quiet life in my family home after working so hard to get here?
These feelings may sound familiar to you, but how can you cope with it? Below, I’ve listed some of the ways which I’ve found particularly useful in the hopes that it helps you.
A stagnant mind is one that likes to dwell on negative feelings.
So get busy! This doesn’t have to mean join a society or go out socialising every day, whilst they’re great options and work very well for a lot of people, they can be daunting within themselves for others. But simply try to make sure you’re getting up and about each day, whether that just means doing a food shop, spending a day taking care of your chores or just taking a walk into town. All these little things can help your brain turn off for a few hours.
I understand that staying busy is something that’s hard to do at night time which is often when feelings of homesickness can hit the hardest. I found, particularly in my first year, that a 20-minute phone call home usually had me feeling a lot better. Whether it be to a friend or a family member. It really helps you realise that they’re still there no matter how far away you are.
Organise a schedule for returning home
Upon arriving to university in September, it may seem like a great idea to head home as soon as the opportunity allows but I must say, I feel like holding out for those first few months can really benefit you in the long run. But that’s a scary thought when all you want to do is go home.
I found a good middle ground was to book my journey home in advance. That way I had a date to look forward to and it helped put my feelings into perspective.
Talk to someone
Similar to the phone calls, a lot of emotion can build up if we don’t vocalise what we’re feeling. If you talk to your friends/flatmates at university about your thoughts and feelings, they may be able to both sympathise and also give perhaps a different perspective.
Of course, if you don’t feel confident talking to the people you know. The university have staff with years of experience dedicated to trying to help you through not just your studies, but your life in Lincoln, this includes listening and giving advice to those of us who are being troubled with feelings of homesickness.
You can contact the university’s wellbeing centre by email or phone, you can also find them on campus next, they are next to The Swan & Stephen Langton Building. The details to contact them are as follows:
By Email: firstname.lastname@example.org.
By Phone: 01522 886400

domain: psychology


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Diego Pablo Simeone González, known professionally as Diego Simeone and fondly referred to as Cholo, is the manager of Club Atlético de Madrid, a club in La Liga, the top flight of Spanish club football.
He has managed the club since 2011 and is one of the longest serving managers in modern football. He is also the longest serving manager in Spain.
Before managing Atléti, he managed Racing Club de Avellaneda, Club Estudiantes de La Plata, Club Atlético River Plate and Club Atlético San Lorenzo de Almagro, all in Argentina, and Catania SSD in Italy.
Diego Simeone teams coached
Diego Simeone got into management immediately after he retired from active football in 2006. He is a very energetic figure who likes to set up his teams to focus on defence.
His 16-year managerial career has been largely successful playing in this way, even though he gets criticized a lot for his ultra-defensive tactics.
Here is information on the clubs that Simeone has managed to date.
Racing Club de Avellaneda
Diego Simeone was the manager of Racing Club on two different occasions. He spent a combined eight months at the club. His first stint was from February 20, 2006 to May 17, 2006 and his second was five years later, starting from July 1, 2001 to December 19, 2011.
He was appointed to the role for the first time, a day after his retirement from active football. He replaced the man who managed him and his former teammates in the 2005/06 Argentine League season and helped stabilize the club before leaving in May.
He returned in July 2011 after Racing Club’s manager resigned, but did not stay long in the role, leaving in December 2011 for Atléti. In those two stints, Simeone managed Racing Club for a combined 33 matches, winning 12, drawing 13 and losing 8 of them.
Club Estudiantes de La Plata
Diego Simeone managed Estudiantes between May 18, 2006 and December 31, 2007. He took up the role after his first stint at Racing Club.
His first in the role was a year of great success for his new managerial career, as he was voted the best manager in Argentina after leading the club to their second league title in 23 years. He could not keep it up the following year though.
Before leaving the role, Diego Simeone managed the team for 61 matches, winning 34, drawing 15 and losing 12. He won the Argentine Primera División Torneo Apertura in his time at the club.
Club Atlético River Plate
Diego Simeone was unveiled as manager on December 15, 2007 and managed River Plate from January 1, 2008 to November 9, 2008.
His tenure at the club started on a poor note but he ended up turning it around and winning the league title with the club. Things soon reverted to the way they were when he was first appointed, and he resigned in November 2008.
Simeone managed the club for 45 matches. He won 20, drew 13 and lost 12. He won the Argentine Primera División Torneo Clausura in his time at the club.
Club Atlético San Lorenzo de Almagro
Diego Simeone managed San Lorenzo from April 20, 2009 to April 3, 2010 after a few months without a job. However, not much changed from his last job as he found it difficult to grind out results.
He lost almost as many matches as he won in his time as the manager of San Lorenzo, and eventually had to resign as the criticism mounted. Simeone took charge of San Lorenzo for 49 matches, winning 22, drawing nine and losing 18.
Diego Simeone managed Catania between January 19 and June 30, 2011. He was appointed as Marco Giampaolo’s replacement after the Italian’s poor returns in the first half of the season.
The break from management between his resignation from his last job in April 2010 and January when he was appointed as Catania’s manager helped Simeone. He was able to right a lot of the previous manager’s mistakes and helped them to safety in the Italian Serie A.
Simeone managed the team for the remaining 18 matches of that season, winning seven, drawing three and losing eight.
Club Atlético de Madrid
Diego Simeone has managed Atlético Madrid since December 23, 2011, when he replaced Gregorio Manzano whose poor run of results put the club in a sticky situation.
His appointment was met with approval from fans of the club because he had had a successful career as a player for the club. He eventually helped the club to a fifth place finish but also led the team to Europa League victory.
His first full season, the 2012/13 season, was also a success compared to the last decade of the club. He helped them finish in third place, which was their best ever La Liga finish in 13 years at the time. He also won the Copa del Rey against Atléti’s city rivals Real Madrid in their own stadium, the Santiago Bernabeu.
He had become a fan favourite by the 2013/14 season and he rewarded their support with a league title win. The manner in which he won the titles however, was more impressive than the win itself. The 2013/14 season ended up being the most successful season in the history of the club.
He has since gone on to win a few more trophies and has appeared at a few more finals with the club, including the UEFA Champions League final. He lost both finals to Real Madrid. He is currently expected to end his time at Atlético in 2024.
Simeone has managed the team for 581 matches so far. He has won 342, drawn 135 and lost 104 of those matches. He has won La Liga, Copa del Rey, Supercopa de España, the UEFA Europa League and the UEFA Super Cup in this time.
Diego Simeone trophies won
During his career, Diego Simeone has won 10 trophies. Here is a breakdown of the trophies he has won in his career.
|Argentine Primera División Torneo Apertura||1|
|Argentine Primera División Torneo Clausura||1|
|Copa del Rey||1|
|Supercopa de España||1|
|UEFA Europa League||2|
|UEFA Super Cup||2|

domain: sports


text:
It is fine to keep working past your State Retirement Age unless your employment is subject to retirement at a compulsory retirement age. If your employer does this, they must give a good reason, for example: the job requires certain physical abilities (e.g. in the construction industry) or the job has an age limit set by law (e.g. the fire service).
To be clear, a forced retirement age of 65 no longer exists.
You can also ask your employer if you can work more flexibly or work part-time. They have the right to reject your request.
You can claim your State pension while you are working, as long as you’ve reached the State Pension age. You can also work if you are claiming a personal or workplace pension. However, check with your pension provider or employer if you have a workplace pension as reducing your working hours could affect how much pension you will receive. You should also check to see what happens to your workplace pension if you continue working beyond the age when you can take it.
If you delay (defer) taking your State Pension, you will get larger weekly payments when you do start taking your pension.
You don’t pay National Insurance if you work past State Pension age.
- Deadline approaching for checking property details - February 2, 2023
- Tax Diary February/March 2023 - January 31, 2023
- PAYE and overseas employees 24773 - January 31, 2023
- When you must register for VAT - January 31, 2023
- Limits to tax relief for pension contributions - January 31, 2023
- Corporation tax changes April 2023 - January 31, 2023
- Do not get caught out by dodgy job ads - January 31, 2023
- Electric car owners to save money under landmark initiative - January 26, 2023

domain: law


text:
Parkour, running and free-running will make the basis of a new performance piece by Kelly Miller, which is set to explore time, space and place. And if that sounds a bit tiring, be thankful that the title Running | Out Of Time has been shorted to R | OOT, which will hopefully save your breath, at least a bit.
What will happen is this: Participants are given a time code that guides them through a city landscape with a set of free-running instructions. Video recording their experience, they will upload the footage to an online global platform where it will be broadcast simultaneously with other participants performing the same task in different cities around the world.
This project aims to choreograph female parkourists and free-runners, innovators and recreators in their place, connected by time and technology but spread across the globe in very different cities.
You can take part or just watch as the platform becomes populated.
The R | OOT starting gun goes off at the launch on November 21, will be through an installation of the first five videos recorded at a private view. Then it’s free-running for all!
To find out more about, put your trainers on and point your feet to R | OOT.

domain: geography


text:
Named after the small town on the Isle of Lewis in the Outer Hebrides, Stornoway is a series by London-based screenwriter and photographer Charlotte Colbert, and chronicles a journey through Scotland.
Each image is a triptych of photographs of a similar subject captured moments apart. The sequencing introduces movement and builds an atmosphere and sense of place. Each panorama is named after the specific timeframe at which it was taken, allowing the viewer to follow traces of a story.
Through the deliberate use of the negative frame from the 35mm black-and-white film she uses, the artist introduces a distance between the viewer and the work. This acts as a reminder that we are not just looking at a record of a place, but at photography as creative process.


text:
Whether with a lending or difference transfer charge card, debt loan consolidation enables you to combine various financial debts right into a singular regular monthly repayment. However, it doesn’t guarantee lesser rates or even a quicker benefit. debt consolidation
It may also harm your credit report scores initially, depending upon the strategy of financial debt consolidation. However, helping make timely settlements may help your credit ratings recuperate and even enhance over opportunity.
1. Check out Your Credit Rating
Financial debt combination can influence your credit history, depending upon which method you pick. Typically, the procedure starts through identifying your existing financings as well as figuring out just how much of a funding you require to pay off each financial debt. You may at that point look around for lending institutions as well as compare passion costs to discover a positive deal. The moment you have actually been authorized for a personal debt combination funding, your loan provider will deal with repaying the existing debts, and also you will certainly have a singular payment to create each month. debts
The preliminary credit history rating struck from a brand-new debt loan consolidation financing may be small and are going to rebound if you are actually consistent along with your monthly payment actions. Having said that, if you available extra profiles or even sustain even more debt, the impact could possibly last a lot longer.
Also, a lot of financial obligation consolidation choices– including harmony transmission memory cards and personal fundings– possessed source charges that can build up over time. These fees may balance out the advantages of decreasing your total debt-to-income proportion. In addition, lots of debt consolidation car loan methods require you to safeguard the lending with security like your home or even 401( k) profile, which can incorporate danger as well as decrease your borrowing energy.
2. Assessment Your Budget plan
When integrated along with a planning to catch to a finances and lower spending, personal debt combination can easily aid you settle your credit scores memory card differences quicker. It can also spare you cash on interest costs if you train for a low personal car loan fee.
If your credit report is higher enough and also you can easily pay for a brand new funding, consider using a debt consolidation personal digital assistant to observe just how a lot you could possibly save through rolling your visa or mastercard financial debt into one singular remittance. This method might be actually specifically beneficial if you possess a ton of high-interest personal debt coming from visa or mastercard. debt relief
If your credit score isn’t sturdy good enough for a financial debt combination loan, you can attempt various other options such as a balance transmission visa or mastercard or financial debt monitoring program. Merely make certain to pick a company that’s credible and also won’t charge you outrageous charges. Some debt comfort business are out to benefit from folks undone, so make sure. You ought to likewise keep away from personal debt resolution companies, which typically deliver to haggle with your collectors in your place in substitution for a charge.
3. Reduce Expenses
While debt consolidation is a beneficial resource in taking care of a number of debt balances, it’s not an universal remedy for economic blues. The most effective way to leave financial debt is to generate a budget plan and also stay with it. It is actually likewise important to consider that also if you combine your financial obligation, you will certainly still need to have to pay on your lendings.
The primary goal of debt unification is to minimize your rate of interest and month-to-month remittance. This can easily spare you manies thousand of bucks in advancing rate of interest over the lifespan of your financing, particularly if you have higher personal debt equilibriums with high rate of interest.
There are actually several means to consolidate financial obligation, including a personal lending, credit report card remainder transfer and home equity financing. However, these alternatives come along with credit inspections as well as origination expenses that can easily impact your credit report.
A debt resolution solution, alternatively, offers a much more drastic method by encouraging creditors to approve a lot less than the complete volume you owe. This possibility is only advised as a last hope and includes its personal set of charges.
4. Stop Using Credit Score Cards
Credit rating memory card financial obligation combination involves rolling various balances in to one brand new personal debt with a single regular monthly remittance. This strategy makes it possible for customers to streamline their expense repayments, settle their personal debt a lot faster or lower their rates of interest.
Nevertheless, financial obligation loan consolidation isn’t best for everybody. It’s not a great option if you don’t have the motivation to modify your spending routines and also adhere to a settlement planning. It’s likewise certainly not a wonderful service if you do not possess adequate accessible credit rating to apply for a personal debt unification loan or even your credit report is actually too low to obtain the greatest enthusiasm rate on a new charge account.
If you’re thinking about financial debt loan consolidation, it is crucial to know that any type of brand-new charge account you open up– such as a debt combination car loan or even a balance move bank card– are going to induce a challenging inquiry on your debt document. This can momentarily lose your credit score through a few factors, particularly if you request various financial obligation loan consolidation options or even close much of your credit history memory cards as you spend all of them off.
5. Remit in a timely manner
When it involves financial obligation unification, making on-time remittances is necessary. Nevertheless, remittance background make up 35 percent of your credit rating.
If you are actually having trouble maintaining up with numerous higher rate of interest settlements, a debt combination lending or even difference move charge card may be actually the best option. However just before you take the jump, check your cost with a handful of creditors to find what’s on call. And also do not apply excessive opportunities to prevent several hard concerns on your credit report, which can reduce your score.
Other financial obligation comfort options include a financial obligation management plan offered by not-for-profit credit scores therapy firms or discussing along with creditors your own self. However remember that these techniques may possess an unfavorable influence on your credit rating and also don’t stop collection agencies coming from trying to collect what you owe. It’s additionally a really good suggestion to examine your budget plan, reduced investing and also make certain you have a strong settlement method in position. Read through Select’s extensive insurance coverage of individual financing, specialist and tools, health and more.

domain: finance


text:
I use the Yanfly Item Synthesis plug-in. I like it!
I hide recipes in dungeons, and they cost a lot, so players can discover them, and dump excess gold; then they have to find a stove in town (or in a house in the middle of nowhere) to make stuff.
I'm so excited you're continuing to work on Wayfarers! Love the map changes! :D


text:
May 23, 2023
Revolutionizing Radiology with AI, But With Ethics In Mind
Radiology is one of the most technologically innovative medical specialties — it is in a constant state of change and evolution. As AI blazes through industries, upending how things are done and understood, radiology is not immune to AI’s sweeping impact.
But, as our guest Dr. Nina Kottler, Associate Chief Medical Officer, Clinical AI at Radiology Partners, explains — radiology is utilizing AI in ethical ways to improve treatment, efficiency, patient outcomes and experience. But while AI will help revolutionize radiology, and arguably, the entire medical field, fear not — the need for humans will not dissipate any time soon.
Join us as we discuss:
* The constantly evolving field of radiology
* The benefits and ethical challenges of utilizing AI in radiology
* Prerequisites for effective, ethical AI application in medicine

domain: medical


If you can't use a jig, then you can try this.
Get some clamps.
Clamp the receiver solidly to the bench or in a vise. Use a machinists level on the bottom of the receiver to make sure it is level.
Clamp the mount base to the front receiver ring. Check to see if one hole, if drilled too deep, will go into the chamber. If so, make note of that.
Put the machinist's level crossways on the top of the mount. Move the mount base until it is perfectly level. Center punch through one of the base holes, lightly. Double check everything, including using a long straight edge in place of the level. Triple check. Twice.
Then center punch the other base hole. Double check. If all looks good, including by eyeball (it is surprising how accurate a trained eyeball can be), center punch normally and drill ONE hole in the drill press. MAKE SURE you don't drill too deep and drill into the chamber.
Screw down the front base with one screw and mount the scope with just the front base. Set the rear base in place and try the scope. (You are checking for mismatched bases before going any further.) Double check, etc.
If all is OK, remove the scope and the front base, and drill the other front base hole. Double check. Again. If all is OK, repeat the process with the rear base.
Make sure the bolt works; if not, you might have drilled into the bolt lug area behind the chamber and the screw is blocking the bolt from turning, or a rear base screw might be keeping the bolt from going into place. If so, remove the offending screw and shorten it until the bolt clears it. (Do not grind off the locking lug to clear the screw, as I heard of one fellow doing.)


All that bright, happy spring fashion you've been pinning, seeing in stores, reading about: Doesn't it all feel a tad too soon? Not in the sense that you wouldn't want to peel off your gray layers and that dutiful Uniqlo puffy liner in favor of a flimsy, floral mini. But, in reality, you're probably not quite there yet. Whether it's a cold snap down south that'll catch you by surprise, or a full-on arctic blast — those frothy threads are going to have to wait.
Fret not, because there is a way to put your best foot forward in the most sensible of ways — a new sneaker purchase. Not only is it ideal timing to get some fresh active gear with those warmer, clothes-shedding months ahead, but a pair of kicks is sure to put a little spring in your step in more ways than one. Designer duds, athletic trainers that look like they're from the future, and retro soles are all fair game for getting a case of happy feet.


The Inspector-General of Police, Mr Usman Alkali Baba has said the heavy deployment of security operatives to Anambra for Saturday’s election is not meant to scare voters but to reassure them.
Baba who was speaking to stakeholders during a meeting in Anambra State said the election security is designed to cover the three senatorial districts of the state, 21 local government areas, 326 wards and 5,720 polling units across the State.
Baba said: “This massive deployment is not designed to intimidate the law-abiding as being insinuated in some quarters. On the contrary, it is to re-assure them of adequate protection by deterring misguided political elements as well as non-state actors that might be bent on threatening the elections through acts of armed violence or other conducts that violate the provisions of the Electoral Act.
Over 40,000 personnel deployed to Anambra State, ahead of the November 6 polls.


text:
The apple has not come to its perfection this season until the middle
of May; even here, in this west country, the very home of the spirit of
the apple tree! Now it is, or seems, all the more beautiful because of
its lateness, and of an April of snow and sleet and east winds, the
bitter feeling of which is hardly yet out of our blood. If I could
recover the images of all the flowering apple trees I have ever looked
delightedly at, adding those pictured by poets and painters, including
that one beneath which Fiammetta is standing, forever, with that fresh
glad face almost too beautiful for earth, looking out as from pink and
white clouds of the multitudinous blossoms--if I could see all that, I
could not find a match for one of the trees of to-day. It is like
nothing in earth, unless we say that, indescribable in its loveliness,
it is like all other sights in nature which wake in us a sense of the
Undoubtedly the apple trees seem more beautiful to us than all other
blossoming trees, in all lands we have visited, just because it is so
common, so universal--I mean in this west country--so familiar a sight
to everyone from infancy, on which account it has more associations of
a tender and beautiful kind than the others. For however beautiful it
may be intrinsically, the greatest share of the charm is due to the
memories that have come to be part of and one with it--the forgotten
memories they may be called. For they mostly refer to a far period in
our lives, to our early years, to days and events that were happy and
sad. The events themselves have faded from the mind, but they
registered an emotion, cumulative in its effect, which endures and
revives from time to time and is that indefinable feeling, that tender
melancholy and "divine despair," and those idle tears of which the poet
says, "I know not what they mean," which gather to the eyes at the
sight of happy autumn fields and of all lovely natural sights familiar
from of old.
To-day, however, looking at the apple blooms, I find the most
beautifying associations and memories not in a far-off past, but in
visionary apple trees seen no longer ago than last autumn!
And this is how it comes about. In this red and green country of Devon
I am apt to meet with adventures quite unlike those experienced in
other counties, only they are mostly adventures of the spirit.
Lying awake at six o'clock last October, in Exeter, and seeing it was a
grey misty morning, my inclination was to sleep again. I only dozed and
was in the twilight condition when the mind is occupied with idle
images and is now in the waking world, now in dreamland. A thought of
the rivers in the red and green country floated through my brain--of
the Clyst among others; then of the villages on the Clyst; of
Broadclyst, Clyst St. Mary, Clyst St. Lawrence, finally of Clyst Hyden;
and although dozing I half laughed to remember how I went searching for
that same village last May and how I wouldn't ask my way of anyone,
just because it was Clyst Hyden, because the name of that little hidden
rustic village had been written in the hearts of some who had passed
away long ago, far far from home:--how then could I fail to find it?--
it would draw my feet like a magnet!
I remembered how I searched among deep lanes, beyond rows and rows of
ancient hedgerow elms, and how I found its little church and thatched
cottages at last, covered with ivy and roses and creepers, all in a
white and pink cloud of apple blossoms. Searching for it had been great
fun and finding it a delightful experience; why not have the pleasure
once more now that it was May again and the apple orchards in blossom?
No sooner had I asked myself the question than I was on my bicycle
among those same deep lanes, with the unkept hedges and the great
hedgerow elms shutting out a view of the country, searching once more
for the village of Clyst Hyden. And as on the former occasion, years
ago it seemed, I would not enquire my way of anyone. I had found it
then for myself and was determined to do so again, although I had set
out with the vaguest idea as to the right direction.
But hours went by and I could not find it, and now it was growing late.
Through a gap in the hedge I saw the great red globe of the sun quite
near the horizon, and immediately after seeing it I was in a narrow
road with a green border, which stretched away straight before me
further than I could see. Then the thatched cottages of a village came
into sight; all were on one side of the road, and the setting sun
flamed through the trees had kindled road and trees and cottages to a
shining golden flame.
"This is it!" I cried. "This is my little lost village found again, and
it is well I found it so late in the day, for now it looks less like
even the loveliest old village in Devon than one in fairyland, or in
When I came near it that sunset splendour did not pass off and it was
indeed like no earthly village; then people came out from the houses to
gaze at me, and they too were like people glorified with the sunset
light and their faces shone as they advanced hurriedly to meet me,
pointing with their hands and talking and laughing excitedly as if my
arrival among them had been an event of great importance. In a moment
they surrounded and crowded round me, and sitting still among them
looking from radiant face to face I at length found my speech and
exclaimed, "O how beautiful!"
Then a girl pressed forward from among the others, and putting up her
hand she placed it on my temple, the fingers resting on my forehead;
and gazing with a strange earnestness in my eyes she said: "Beautiful?--
only that! Do you see nothing more?"
I answered, looking back into her eyes: "Yes--I think there is
something more but I don't know what it is. Does it come from you--your
eyes--your voice, all this that is passing in my mind?"
"What is passing in your mind?" she asked.
"I don't know. Thoughts--perhaps memories: hundreds, thousands--they
come and go like lightning so that I can't arrest them--not even one!"
She laughed, and the laugh was like her eyes and her voice and the
touch of her hand on my temples.
Was it sad or glad? I don't know, but it was the most beautiful sound I
had ever heard, yet it seemed familiar and stirred me in the strangest
"Let me think," I said.
"Yes, think!" they all together cried laughingly; and then instantly
when I cast my eyes down there was a perfect stillness as if they were
all holding their breath and watching me.
That sudden strange stillness startled me: I lifted my eyes and they
were gone--the radiant beautiful people who had surrounded and
interrogated me, and with them their shining golden village, had all
vanished. There was no village, no deep green lanes and pink and white
clouds of apple blossoms, and it was not May, it was late October and I
was lying in bed in Exeter seeing through the window the red and grey
roofs and chimneys and pale misty white sky.
Sorry, no summary available yet.


text:
The County Clerk is an elected official
provided or by the Washington State
Constitution whose responsibilities
are assigned by local and state rules
Clark County Clerk
- Copy Requests: If you need to request a copy of a document (IE. divorce decree)
- Family Law Instructions: Instructions on forms to use for Domestic Case actions, (IE. Divorce, modifications, Legal Separation, Contempt...)
- Fee Schedule: To determine cost of filing(s)
- Superior Court Case Search This search uses a Washington Courts website (Odyssey Portal) which can search all counties in the State of Washington for cases.
- Superior Court Name Search This search uses a Washington Courts website which can search all counties in the State of Washington for cases.
Contact: Clark County Clerk's Office
Superior Court Schedule Change Criminal Dockets
| Change effective 9/18/2020
Change effective 9/30/2020
See Superior Court webpage
Facilitator Office Changes as of January 4, 2021
Please note: appointments must be scheduled in person. Scheduling by phone not available.


Two businessmen brothers from Delhi who were kidnapped from Patna were found on Wednesday from a jungle in Maoist-affected Lakhisarai district by a Special Investigating Team of police….
Read full article at the publisher’s site: http://ift.tt/2eP9f1M
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Being a klutz I’ve never attempted building my own DAW.
But I am a big proponent of using custom PCs that are built for audio.
One thing the folks that build them do is test the various components for how they behave in an audio production environment - which is different than a general purpose PC, especially related to real-time processing. So I’d recommend taking a look at the offerings from a few custom DAW builders and see what components they are using (and avoiding) in their machines. That way you can use their research for free.
Your post will probably get moved to Computer/Studio Hardware & Setup, at which point the good folks there will fill your head with such science you will no longer know your armpit from your elbow, so for my 2c, you’re already on the right road.
Modern kit is more than enough for audio, but my rule of thumb over the past 5-6 years has been “RME, Intel (no hyperthreading), Gigabyte”, prefer clock speed over number of cores, no dedicated graphics cards (Intel integrated GPU is fine for Cubase) and generally stay away from pure gamer kit (but watch closely what gamers are getting!). I use an SSD for OS and programs, and couple of terabyte “spinners” for cheap storage – if you will be loading a lot of samples, get another SSD for libraries.
I’m not going to expend any energy defending my choices, it’s just what has worked flawlessly for me.


text:
Quick Universal Role Play System
The system is based on the bell curve of three six sided dice ( 3d6) with the standard target number of eleven (11) for average and in oppose rolls. With the starting target number for skills rolls before adjusted from the average to either routine mundane, which are easy tasks. At a eight ( 8 ) and the hard tasks at fourteen (14). Arbitrated by the game master.
The point buy is one for one, and can be adjusted to the level of the game and how experienced one wishes to start their game. For purposes of describing the break down of the point buy. Each player will get ten (10) points to purchase attribute traits. Ten (10) points for skills. Such stipulations as no more then at character creation that an attribute or skill can have no more then three points.
Strength (Used for lifting, throwing things and adding to melee attacks.)
Agility/Coordination (Used in skills such as dancing, picking a lock or in use of a ranged weapon.
Stamina/Resistance (This attribute is ones endurance. And how one resists such things as poisons or diseases.)
Mental faculty (Used for intelligent based skills)
Force of Personality. (This attribute is ones charisma and appearance traits. Used for such skills that are talents. Such as bluff, oratory and seduction as examples.)
Anything can be a skill. Depending on the time period of the game you are running. When performing a skill role. The appropriated corresponding attribute is used with the skill. The total is subtracted from the the target number. For example. Player A is a thief and is trying to break into the merchants iron chest. He is skilled and has open locks 2. His agility/Coordination is also a 2. The lock is a well crafted lock. So the game master sets the target as hard a 14. Now with a total of 4 for attribute and skill appropriate to the task. This is subtracted from the target number. Which makes the target number 10. The player rolls the 3d6 with needing 10 or better on three dice to open the lock.
Unskilled is based on just the attribute.
Combat is simple, again appropriate attribute with the martial skill. (Note in case of such skills as wrestling. A player can choose either strength or Agility/Coordination.) But can only choose one or the other to use. Not both with the skill. Now these skills are opposed by the others corresponding skill sets. To get the adjusted target numbers.
The combat can also be adjusted by weapon and armor. A simple way for this. Is that one handed weapons and range weapons give one point to the total. While two handed weapons give two points to your total.
For armor, partial 1 to defense, full armor gives 2. A shield adds 1, and a full tower shield adds 2 . This is added for the opposed score.
Example of combat. Player A has a large shield, and spear. He goes to attack player B with partial armor of breast plate and shield. Player A has a strength of 3, skilled in use of the spear 2, and 1 more for the spear itself since using it one handed with the shield. His total is 6. Now player B has a agility/coordination of 2, stamina/resistance of 3, partial armor of breast plate of 1 and shield of 1. His total is 7. So the target number is now 12. Unlike skills rolls hitting the target number is not success but a glancing blow of no damage. If player A rolls a 14, then he does 2 points of damage.
Life points is 4 x you Stamina/resistance attribute.
(Getting hurt is a disadvantage. 25% of life points is -1, 50% us -2 and 75% loss of life points is a -3. This is both for combat and skill checks to heal)
(Blunt or stun damage heals back 1 per hour, while lethal damage heals back 1 per day or can be a week Game masters decision.)
Initiative is 3d6 plus a persons agility/coordination and mental faculty added together and then divided in half and applied to the roll result of 3d6.
Gaining skills and raising attributes. For each 10 points gained, can purchase one skill or attribute point.

domain: game


The rifle is made in the configuration of bullpup according to the scheme L.V. Bondarev on the basis of TsKIB SOO (branch of KBP). In the manufacture of the rifle, the experience of developing the VCA was taken into account and a number of its structural solutions were used. The main original feature of the OTs-44 is the forward displacement of the trunk for reloading (a similar reloading scheme was used in the Czech PTR 1940 of the year). Reloading the rifle is done manually.
The rifle is equipped with optical and night sights, conventional bipod and adjustable support-bipod, located in the lower part of the butt. Recoil is weakened by a spring-loaded butt with a damped butt pad.
A rather powerful, large-sized silencer is installed on the rifle, which, like the SCC, is “strongly” pulled over the barrel and hardly increases the length of the barrel. The silencer consists of a cylindrical chamber divided by transverse partitions. However, due to the specificity of the cartridges with a supersonic initial velocity of the bullet, the sound is not completely muffled, but attenuated before the sound of a shot from the SVD. According to the 1997 application, the developers of this rifle: they are working on a similar design for a more powerful 14,5 mm cartridge.
According to some reports, in addition to the standard 12,7 * 108 mm sniper cartridge, a reduced-power cartridge is also produced, which makes it possible to better mask the sound of a shot, although this greatly affects the range of the bullet.
From personal observations: this rifle is very similar to the KSVK, so, I would not be surprised if it is the same weapon, only slightly modified for low noise shooting.
Caliber, mm 12.7х108
Length, mm 1070
Weight unloaded, kg 14.0
Initial bullet speed, m / s 800
count 8 cartridges
firing, m 2000


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Small group sizes and approved, professional tutors
120 stunning UK venues - see our map
Hands-on photography - the best way to learn
A huge choice of one-day workshops to suit your skill level (or private training if you prefer)
Get off Auto
Explore Your Camera Part 1 - Get off Auto and unlock your camera's true potential - our best-selling one-day workshop.
Explore Your Camera Part 2 - Develop your Skills. How to photograph movement, from sport to waterfalls & much more.
From big cats to birds of prey, British wildlife, safaris, photo walks and masterclasses.
A range of workshops including natural light, flash, studio lighting, styling shots and photographing live performances.
Landscapes & Water
A range of landscape and flowing water workshops and evening photo walks.
Close-Up & Macro
How to get sharp shots every time, from detailed close-ups to arty images.
Two workshops to perfect your skills - a 2-day Introduction and Wedding Masterclasses.
Composition - Get Creative
Transform your landscape, portrait and close-up photos on this 'must-do' workshop
Low Light & Flash
Use your camera and hot-shoe mounted flash (speedlight) to capture images in challenging conditions.
Street & Travel
Lots of opportunities to develop your photographic 'eye' and refine the skills you've already learned.
Motorsport & Sports
Join us on location at a sporting event to learn how to photograph fast action and create a feeling of movement.
One-to-One Bespoke Days
For a real treat you can have one of our experienced tutors to yourself on a day tailored to your requirements.
Photography for Businesses
Learn how to produce your own product, event & lifestyle images with training tailored to your requirements.
Win one of three £50 Going Digital Gift Vouchers. Take a look at our August photography competition for full details >>
If you're a Going Digital student past or present, you're welcome to join our student group where you can ask questions and share advice and information. Just click on this link and ask to join the group, or ask your local tutor.
Our experienced tutors will show you how to get the best from your camera, whatever the make or model.


Quinta Brunson capped off her unimaginable yr with an Emmy win for excellent writing for a comedy sequence on Sept. 12. During her speech, the “Abbott Elementary” creator and star thanked her husband, which got here as a shock as a result of Brunson could be very low-key about their relationship. Here’s what we learn about Brunson’s husband, Kevin Jay Anik.
Brunson posted a photograph of her engagement ring on Instagram
Anik does not have any public-facing social media of his personal and appears content material to remain within the background and let his well-known accomplice take the highlight. He did pose for one photograph with Brunson on the Emmys on Monday night time, nonetheless. He additionally attended the Time 100 gala together with her again in June.
For now, Brunson is unquestionably celebrating her show’s three Emmy wins. In addition to her personal victory, her costar Sheryl Lee Ralph received excellent supporting actress in a comedy sequence, and the present received excellent casting for a comedy sequence. During her acceptance speech, Brunson known as her husband “essentially the most supportive man I’ve ever recognized.” She additionally thanked her household, her inventive companions, her mentors, and the present’s solid.
Season two of “Abbott Elementary” premieres Sept. 21 on ABC. The community bumped the sequence order as much as 22 episodes, which means we’ll have many extra hours of laughter to return due to the gang at Abbott. Brunson may also seem as Oprah in the upcoming Weird Al biopic, starring Daniel Radcliffe.
Quinta Brunson and Husband Kevin Jay Anik on the 2022 Time 100


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Turn off your mind relax and float downstream.
Welcome to Literary Kicks, a website about literature. It’s also about music, philosophy, Internet culture, pacifism, visual art, world history, literary criticism, pop culture, politics, bad television.
This is my website — the name is Marc though I’m also known as Levi, and it’s nice to meet you. Literary Kicks is my personal labor of love, and I basically publish anything I think my readers will be interested in. I’ve been running this website nonstop since 1994, so I guess it must be my idea of fun.
I also share literary links on Facebook, and occasionally post smart-alecky comments about whatever is going on in the world on Twitter. Please also check out my Instagram if you have any desire to see the world through my eyes.
I don’t often run contributed articles, but if you have an idea that seems to be right up Litkicks’s alley, please pitch me at firstname.lastname@example.org.
You can also use that email address if you’d like to call my attention to a book, but please know that I absolutely do not review emerging writers on Literary Kicks. I am stating this emphatically because many young writers or their publicists put a lot of effort into sending me very clever emails inviting me to read their newly published novels or short story collections. But I simply don’t have time, and I only select new works of fiction to read based on word of mouth. (I make a living as a software developer, and I never have enough time to read as many books as I wish I could.)
Please query me before sending review copies. My address is:
PO Box 751246
Forest Hills, NY 11375 USA
Now … if you’d like to hear about the ancient history of this website, and all that madman stuff, you can read my memoir of the Silicon Alley boom and crash (1993 to 2003). It’s a pretty good story and I’m still planning to publish it as a book when I can find the time for one more round of revision.
Here’s a June 2015 podcast interview at BreakThru Radio in which I talk about the history of Litkicks and lots of other things.
Here’s an interview I did at The Nervous Breakdown on the 20th birthday of Literary Kicks.
I built this site because I believe literature can change the world. It hasn’t yet, but that only means we’re not writing hard enough yet. Hope you enjoy your visit to Literary Kicks.


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When you purchase a digital subscription to Cake Central Magazine, you will get an instant and automatic download of the most recent issue.
Fresh orange cake with orange cream cheese frosting. Royal roses and buttercream.
Pink, Red, White Birthday Cake
This is very pretty...I envy your handwriting abilities :D
(if this is a private computer)
Yes please, register now!


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Writing skills, literature appreciation, reading comprehension
I have an extensive background in writing, editing, and publishing. My experience includes a career in human resources and policy writing, proprietor of a rare book shop, and managing editor at a small press. I have lectured on historical...
Vocabulary, Grammar, Reading
| 10+ other subjects

domain: library


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Despite geopolitical uncertainty and a slowing in the economic cycle, investment in the global property market has seen a significant rise of 18% year-on-year to a new record high of $1.8tn (2017: $1.5tn), according to research out today from Cushman & Wakefield.
‘Winning in Growth Cities’ is an annual report which examines global commercial real estate investment activity, assessing cities by their success at attracting capital.
The 18% increase in commercial real estate investment is being led by Asia, both as a source of capital and as an investment destination, with investment in Asia accounting for 52% of all activity and Asian buyers responsible for 45% of all cross-border investment.
Carlo Barel di Sant’Albano, Head of Global Capital Markets at Cushman & Wakefield, said:
“There is no shortage of capital targeting real estate across myriad geographies and risk profiles. Indeed, we are seeing many investors increasing their allocations to real estate and they are evolving their strategies to allow for variable supply and risk tolerances. These are the key factors determining whether volumes rise further still; given the current environment, volumes could exceed current levels by up to 2% next year. This is likely to be led by global buying, but investors need to keep a close eye on structural shifts in the occupational market as both an opportunity and a challenge.”


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A new hub has been set up on Liverpool’s Bold Street with an aim for it to become one of the city’s key creative and digital workspaces.
Design agency Uniform is behind the second floor Bold Street Studios facility, which it hopes will become as prominent as the likes of the Baltic Triangle’s Baltic Creative.
The hub is one of several new occupants for Bold Street, with Indian street food and craft beer concept Bundobust and bike retailer Cycle Republic also preparing to open new branches.
Bundobust, which already has eateries in Manchester and Leeds, announced yesterday (29 October) that it has now signed the lease on its upper floor unit, paving the way for work to start on-site next week and an early 2019 opening.
— Bundobust Liverpool (@BundobustLiv) October 29, 2018
Uniform, which is based above on the third floor, plans for Bold Street Studios to host regular events for creative businesses such as BIMA breakfasts, and a bi-annual student illustration competition to animate the entrance space up to the second floor units has been launched.
Managing director Nick Howe says: “Because we invested in the building, we take good care of it. We’re just people upstairs who care – with a mission to collaborate and better connect Liverpool’s creative community.”
Worthington Owen has been appointed to work as letting agent on Bold Street Studios’ workspaces.

domain: design


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Kev and I went out hunting yesterday. I didn't go to "The Hill" because there are some rifle hunters there, and I didn't want to be in their way. So, instead, Kev took me out to the ranch where he got his deer.
The Ranch belongs to the D family. They are a big land owner in Clark County, with farming and ranching operations. Daddy is in charge of the ranching end, cause he don't do farmin'. He's a cowboy through and through.
Anyway, they have several Mule deer who stay on their property, so we thought we'd try it. Kev and I sat for a while in a little hole down in a draw near the wheat and Milo fields. We scared out 2 does when we walked in and that was all the deer we saw.
Around 8:30 a.m., we decided to go check out some canyons. Mule deer like canyons. They can bed down on the side of a canyon and be out of the wind. On cold days, they like to bed down on the north side so that the sun can warm them all day as they sleep. Plus, the wind usually blows from the north, so they get the added bonus of being out of the wind.
Kev drove me over to the east side of the Ranch to some canyons he's been watching and it's an area he thinks is pretty as well. As we drove in, we saw a couple of antelope does. Can't shoot them, but it was nice to see them.
Then, we got to the canyons. Kev wasn't kidding; it's beautiful country. Made me wish that I had a camera along. Folks, if you think Kansas is flat, then you need to get off the Interstate and drive to our area. Canyon after canyon after canyon as far as the eye can see. Not little canyons either, but deep canyons. Some are deeper than 100 feet and are rather...vertical.
We parked the pickup near an autogate [insert lustful sigh] and walked about 1/4 mile over to one canyon. We didn't see any deer, but decided to follow the canyon around to the east and then circle with the canyons to the south and then we would walk back west to the pickup.
So, we angled down some, and around and walked and walked and walked and walked. I had my hunting gear on; my coveralls and my coat and was carrying my bow. It was a fun and beautiful walk. We not only looked for deer, but we enjoyed the beauty of the rocks and the canyons and the creek running through the bottom.
After about an hour of going up and down and around, we came to the Southeast corner. Somehow, even though we weren't at the bottom of any canyon, we were now closer to the bottom than we were to the top. And it was great, it was fun. I was enjoying myself until we turned the corner and saw the way out. To get back to the pickup, we had to walk back up hill, all the way. And it was a rocky and steep trip. We had to climb up several hills and sides of canyons, and it was pretty steep, and, and...
I got tired. Really tired. Tired enough that I stopped several times to rest and I was tired enough to really resent my coveralls. And my coat, my sweatshirt, and my bow, and especially my husband. Who at one point said to me, "You are really out of shape." Of course, he wasn't wearing coveralls. And his coat was lighter, he wasn't wearing a sweatshirt, and he wasn't carrying a bow either. And...and...well, maybe I am out of shape. But he didn't have to rub it in. I think this was about the time when I suggested that he go get Dad and a horse. And then I mentioned if he fell and broke something, I was just going to have to leave him to die, cause there was not way I could get him out of there. Of course he wondered why I'd warrant a horse, but he'd be left to die.
Even when we got out of the canyons, we still had an uphill trek back to the pickup. And I was tired. And besides being tired, my hands hurt from carrying my bow, and I was very sweaty. My t-shirt was rather damp next to my skin under the sweatshirt and coveralls and coat.
I talked to my Dad later on the phone and told him what we'd done and where we were. When I mentioned how steep it was coming out and how tired I got, he laughed and said "You can drive down there to the bottom on the far southeast side, but when you come back up, if you've got anything in the back of the pickup, it's going to slide out." Usually, he just goes horseback down there, it's easier. I know why, but I'm not sure exactly where you'd drive down.
But, I loved every minute of the walk. It was beautiful. It was refreshing. It made me thankful that I can see and appreciate the beauty of this area--even when I'd tired. So, if you think Kansas is flat, stop by and we'll just go hiking to the bottom of a canyon. Just leave your coat and coveralls and bow at home. You'll thank me later.


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You are reading about which is the smartest country in the world. Here are the best content from the team nguyendinhchieu.edu.vn synthesized and compiled from many sources, see more in the category How To.
Smartest Countries in the World 2023
Smartest Countries 2023
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For our latest video on board a cruise ship, our presenter spent some time with the man in charge of P&O Cruises Britannia! The captain is in charge of everything that happens on board, and can be called on at any time of the night and day. This is the latest in our Just The Job series, so if you enjoyed it, take a look at some of the other videos in this section, which show you lots of different jobs that you can do after leaving school. We’ve got lots more coming up, so keep checking back to see what’s new!
What’s the job?
Captain of a cruise ship.
Who would I be working for?
Cruise companies such as P&O Cruises, who sail passengers to amazing locations around the world and provide all sorts of entertainment for them while they’re on board.
What do they do?
The captain is in charge of the navigation of the ship, as well as the safety, security and health of everyone on board. They also have to understand all of the legal regulations dealing with shipping and environmental issues, so it’s a lot of responsibility.
What sort of work is involved?
- Making decisions about the ship’s route, based on navigational charts and weather reports.
- Giving instructions to team leaders and making sure that any problems or complaints are dealt with.
- Working with staff and speaking to passengers to ensure that everyone on board is safe and enjoying their journey.
- Keeping up to date on local and global laws, to make sure that the ship doesn’t break any rules or go anywhere it shouldn’t.
What skills do I need?
- Leadership ability. You’ll need to be in charge of a lot of people in very different roles.
- A friendly and approachable manner, as you’ll need to talk to members of your team and passengers at all times.
- Ability to stay calm under pressure and keep focused.
- You should be able to assess a situation quickly, using lots of sources of information, and make speedy decisions.
- Organisational skills are a must, as there are lots of laws and regulations that a ship’s captain needs to be aware of at all times.
- Numerical skills are important, as the captain has to make sure that all budgets are met.
What qualifications do I need?
Subjects such as maths, English and physics are very useful, but the ultimate qualification you need is something called a master unlimited (II/2) certificate. To get this, you would need to pass lots of exams leading up to it and have a lot of years of experience on board a ship. Experience on board various types of ships is also an absolute must, and it’s likely that you’ll need to have had the rank of deputy captain or higher on another cruise ship before you can become captain.
Anything else I need?
You’ll definitely need a passport!
What hours would I work?
As the captain, you could be called on at any hour of the day to deal with a problem. That means you might be sleeping at odd hours and taking short breaks throughout the day. But there’s nowhere better than a cruise ship to relax and unwind! Like everyone else on a cruise ship, you might be at sea for something like ten weeks at a time, but then get ten weeks off when you return home.
Where would I work?
Wherever your ship goes! That could be places such as the Caribbean or Mediterranean, Norway or the Baltic Sea, or even a full round-the-world cruise.
How much would I get paid?
It can vary a lot, depending on your experience and the size of the ship you’re in command of, but you’re likely to be earning more than £70,000 a year.
Can I do work experience?
P&O Cruises run a cadet programme, where people at school, college or university can sign up to get experience and learn the trade, while also getting to see the world! The minimum qualifications you need to enter are four GCSEs (or equivalent) at grade A* – C (9 – 4 in the new grading system), including maths, English and science. You can find out more information in the cadets section of the Carnival careers site. If you take a look elsewhere on the careers site, you can get an idea of the huge range of jobs on offer to anyone who’s interested in joining the team on board a cruise ship.
How might the job change in the future?
Navigation systems and safety technology are improving all the time. But no matter how much technology advances or how good ships get at piloting themselves, ships will almost certainly always need a captain on board.
Don’t fancy being the captain? How about managing the entertainment on board instead?
See all of our Just The Job videos.

domain: travel


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(PEE-nile KAN-ser) A rare cancer that forms in the penis (an external male reproductive organ). Most penile cancers are squamous cell carcinomas (cancer that begins in flat cells lining the penis).
Frequently Asked Questions
- Have question on Penile cancer? Ask in the Question portal.
- FAQ's on Penile cancer
- Frequently Asked Questions


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This “no knead” bread is just delicious and very simple. It’s too hot to knead, frankly, and the heat of the summer enables the biga to develop quickly so just 10 hours of life gives it a lot of life and flavour.
Last night we had fish for dinner with mashed potatoes and baby beetroot, fresh from the garden. With a few beets left over and about a coffee mug of left over mash (made with cream and butter, salt and pepper), it was time to mix a biga together for this morning.
Add the mash and the diced beets in at the end, give it a little knead so you don’t squash them all and then just stretch and fold to finish the dough off. The result is chewy, flavourful bread, delightfully dotted with bits of purple beet.
Ciabatta with potato, rosemary and beetroot
Day One make the Biga)
- 330 g Strong white wheat flour
- 260 g Water
- Pinch of yeast of whatever tyoe you have
- 6 g Salt
Day Two make the dough)
- Biga from day before
- 500 g Flour
- 360 g Water
- 3 g Yeast of whatever type you have
- 10 g Salt
- Coffee mug of left over mash
- 1 Medium Beetroor cut into 1cm dices
- 4-5 Sprigs Rosemart neeeles strippedd of and roughly chopped
Day One – Use the Day One ingredients from above
- Measure the water into a big bowl and add the yeast. Wait for 5 minutes for it to dissolve and then add the flour and the salt. Stir. Cover. Leave over night (or up to 24 hours)
Day Two – Use the Day Two ingredients from above
- Add the water to the bowl and then add the yeast. Wait for five minutes to let the yeast dissolve and then squish the biga/water mixture together with your hands to make a milky paste.
- Add the fresh flour and the salt. Stir it all together well. Add the potato and the rosemary and give it another stir/knead to make sure it's all incorporated evenly and then add the beets and give the dough another gentle stir/knead so you don't squash the beets to death.
- Cover the dough and leave it for 30 minutes.
- Lovely open crumb, beautiful to look and and amazing to eat!Image note: Lovely open crumb, beautiful to look and and amazing to eat!
- Stretch and fold the dough and then let it rest for 30 minutes.
- Repeat this four times. If you are not sure what it means to "stretch and fold" you can watch a little video. https://www.youtube.com/watch?v=2zM50RHnWvE
- Scrape the dough out onto a lightly floured surface and divide it into four equal pieces.
- Cover and let rest for 20 minutes.
- Shape the dough into a ciabatta shape.
- Cover and let rest for 30 minutes.
- Preheat the oven to 230 degrees C and pop the dough in. Bake for 20 minutes and then remove and let cool completely on a cooling rack.
Devour. YUM! Come and learn to bake bread with us! Click here to take a bread course – type “Italian” into the search bar if you want to learn how to bake ciabatta!

domain: food


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Albumin is a key component in life-saving vaccine and biopharmaceutical formulations, where it stabilises active ingredients and extends shelf-life. Recombinant albumin in particular has gained market share in recent years, partly to allay regulators’ concerns about viral contamination. However, not all recombinant albumins are the same, and the risks associated with batch-to-batch inconsistency and performance deficit deserve far greater scrutiny.
Product performance carries risks
In a sector with revenues of many millions, if not billions of dollars, the stakes are high, even when the risks are perceived as low. Lost batches leading to lower gross margins are just one consequence of a deficit in product performance for patent protected biopharmaceuticals and cell therapies containing human albumin ingredients. Adversely affected patients are another, far more serious potential consequence. This is especially true for products containing plasma-derived albumin, where the inherent risk of viral or prion pathogen contamination cannot be fully eliminated. Worse-case scenarios from a commercial perspective include regulatory suspension of market access, adverse publicity and loss of preference from key buyers.
Recombinant albumin is not a blunt instrument
Using recombinant albumin does mitigate these risks. At present, recombinant albumin is commercially available at scale from rice (Oryza sativa) or from yeasts such as Pichia pastoris and Saccharomyces cerevisiae (baker’s yeast). For many years, recombinant albumin from baker’s yeast was only available in its most pure and expensive forms, which are arguably over-engineered for some applications.
Albumin is a complex molecule, however. The factors that influence its performance and safety such as differences in potentially immunogenic post-translational modifications (PTMs), bound ligands, and process-related impurities, need to be expertly handled. So do costs. The highest quality recombinant albumin can be prohibitively expensive due to restricted supply. Lower-cost albumins are less expensive, but may have significant drawbacks in terms of safety and performance that aren’t always highlighted.
Drawbacks of rice and Pichia
While recombinant albumin from Pichia pastoris or rice is adequately functional in many cases, it has also been independently shown to contain potentially immunogenetic PTMs, which would be undesirable in injectable human therapeutics and cell therapies. Differences in the process-related impurities and bound ligands can impact performance, especially for cell therapies. Significant losses of correct albumin isoform occur during downstream processing when removing small amounts of albumin with undesirable PTMs, which are chemically very similar and difficult to separate.
QTL strains enable a range of purity levels
Fortunately, new strains of Saccharomyces cerevisiae for the manufacture of recombinant albumin are now being created at a range of purity levels, all controlled for undesirable PTMs. This has been made possible by the deployment of new QTL technology, resulting in albumin that is of the highest quality and suitable for the most challenging applications, including cell therapy development and manufacture.
This new generation of recombinant albumin provides a safer alternative to animal-derived albumin. Clinical testing demonstrates that albumin from Saccharomyces cerevisiae has an acceptable PTM profile. Baker’s yeast does not have any pathogenic lytic viruses or prions of concern. It has GRAS status (generally regarded as safe), with a long and safe track record in biopharmaceutical manufacturing, including insulins.
Improving access to recombinant albumin
Bespoke optimisation of production strains enabled by QTL technology promises to broaden access to premium quality albumin at lower prices, accelerating the transition away from animal-derived albumin.
That can only happen safely, however, if there is greater transparency about the PTM profiles and associated risks of different recombinant albumins on the market.

domain: literature