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With many golf courses in Wisconsin already open and hundreds more hoping to follow suit in the coming weeks, course owners and operators and the golfers who will patronize them are cautiously optimistic in the face of uncertainty about how the coronavirus will impact the industry.
The annual Milwaukee Golf Show, held over the weekend at State Fair Park, was a sign of the times, with attendance far off the norm. But those who did show up to gather information about courses and resorts, try new equipment and shop for discounted apparel, shoes and golf balls didn’t seem overly concerned about COVID-19, which has brought much of the world to a standstill.
“I’ll be honest, I’m actually kind of surprised at the number of people that are here,” Blake Conklin, director of golf and group sales at Old Kinderhook in Camdenton, Mo., said Saturday. “I really didn’t have a great feel for what it was going to be like. It’s nice to see that people are coming out.”
However, it was impossible not to notice the numerous empty booths. Jay Royle, the show owner, said about 25 percent of the vendors pulled out. Among the no-shows were Erin Hills, University Ridge, New Berlin Hills, Reedsburg Country Club and Eagle Ridge Resort in Galena, Ill.
Josh Redo, the director of Par 5 Resort in Mishicot (formerly Fox Hills), said operators representing Timberstone, Greywalls and the Island Resort & Casino in the Upper Peninsula set up their booth on Friday but within hours took it down and left.
“I guess they got a call from their bosses telling them to come home,” Redo said. “We thought we would weather the storm. It’s interesting times, but we’re here.”
Conklin said he never considered not coming to the show.
“I guess I’m one of those that thinks (coronavirus) is a little overblown and I think everybody here is the same way,” he said. “Between (Friday) and today, we’ve talked to a lot of good people. The numbers may be down a little, but we’re talking to people that are very engaged in golf.”
Still, the aisles at the Wisconsin Exposition Center, normally crowded at mid-day Saturday of the show, were eerily empty. One vendor said he saw some people show up for the free sleeve of golf balls handed out to attendees, then turn around and leave.
The show opened at 10 a.m. and at noon attendance couldn’t have been more than a few hundred, despite Royle dropping the price of tickets sold at the door from $10 to the advance sale price of $7.
“I know last year they said we did 13,000 people over the course of the weekend and it’s probably going to be half that,” Redo said. “It’s still pretty impressive that people are out here. We’ve had good traffic.”
Hand sanitizer was available at the entry and exits and some vendors had their own bottles. Many people greeted each other with fist bumps or touched elbows, though plenty shook hands, too.
“Everybody is an adult, they make their own decisions,” Royle said. “We’re getting through it and making the best of it. But we’re happy with the turnout. A lot of people have thanked us for staying open. We’re doing our best to make it an enjoyable experience. A lot of people are glad we stuck it out and glad they came.”
He said he did not consider pulling the plug on the show.
“The golf show is a renter at State Fair Park,” he said. “We’re going to proceed as normal until State Fair Park tells us otherwise. There’s other events going on here this weekend. Another thing, not everybody is closing. There’s a lot of businesses open in this town. Is Potawatomi closing down? Costco? Walmart? There’s plenty of people there, too.”
No one knows what coronavirus will mean to the spring golf season in Wisconsin, whether courses will be asked to close or will do so on their own and, if so, when they would reopen. But some owners and operators pointed out that golf is played outdoors and golfers generally do not have to be in close proximity to one another unless they share a motorized cart.
Also, some reasoned, with no live sports on television for the foreseeable future, schools and churches closed and numerous events canceled or postponed, people will want something to do and golf could provide an escape of sorts.
“I think people in general are very excited about the season coming up, the weather changing and getting outside,” said Ryan Stray, who along with his wife Kelsey purchased Old Hickory Golf Club in Beaver Dam last August. “We all know what’s going on in the world right now, and the last thing anybody wants to do is keep perpetuating that. But golf offers them a place to get out and enjoy themselves.”
Jason Ribard, the general manager at Young’s Golf Recreation and Dining in Iron River, Mich., agreed.
“People are going to get shack-happy, so it definitely could help (participation),” he said. “Honestly, I see this kind of panic being over in a couple weeks, especially in the U.P.”
Only time will tell.

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A polypeptide having bactericidal activity, particularly against gram-negative bacteria, has been isolated from pig intestine. The porcine cecropin has the amino acid sequence: H.sub.2 N-Ser-Trp-Leu-Ser-Lys-Thr-Ala-Lys-Lys-Leu-Glu-Asn-Ser-AlaLys-Lys-Arg-Ile-S er-Glu-Gly-Ile-Ala-Ile-Ala-Ile-Gln-Gly-Gly-Pro-Arg-COOh. Pharmaceutical compositions containing such poypeptides, or functional derivatives thereof, are useful in therapeutic and prophylactic methods for inhibiting bacterial growth.
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The present invention relates to new polypeptides having bactericidal activity in that they are capable of killing certain bacteria, particularly gram-negative ones. The invention also covers pharmaceutical compositions and methods of use for the inhibition of bacterial growth.
The small intestine is an important endocrine organ and a number of physiologically active peptides have been initially isolated from porcine tissue (Mutt, V., Chemica Scripta 26B, 191-207 (1986)). During normal healthy conditions, the upper part of the small intestine contains few bacteria. Below the duodenum the concentration of bacteria progressively increases until the maximum, 10.sup.11 bacteria per g of feces, is reached in the large intestine. It is remarkable that such a mass of bacteria can coexist with a delicate host organ. Small basic peptides called cecropins play an important role in inset immunity (Boman, H. G. & Hultmark, D., D. Ann. Rev. Microbiol. 41, 103-126 (1987)) and structurally unrelated peptides called magainins (Zasloff, M., Proc. Natl. Acad. Sci. U.S.A., 84, 5449-5453 (1987)) protect the frog skin from infections. Another group of antibacterial peptides, the definsins were first isolated from mammalian granulocytes (Selstedt, M. E., Szklarek, D. & Lehrer, R. I. Infect. Immun. 45, 150.154 (1984)) and neutrophils (Selstedt, M. E., Brown, D. M., DeLange, R. J., Harwig, S. S. & Lehrer, R. I., J. Biol. Chem. 260, 4579-4584 (1985)) and recently also from insects (Matsuyama, K. & Natori, S. J. Biol. Chem. 263, 17112-17116 (1988); Lambert, J. et al. Proc. Natl. Acad. Sci. U.S.A. 86, 262-266 (1989)). In addition, bovine neutrophils have been found to contain bactenecins (Romeo, D., Skerlavaj, B., Bolognesi, M & Gennaro, R. J. Biol. Chem. 263, 9573-9575 (1988), another small basic peptide. Both definsins and bactenecins contain one or more disulfide bridges while cecropins and magainins are cysteine-free.
The present invention has for an object to provide new bactericidal polypeptides capable of inhibiting bacterial growth, in particular the growth of gram negative bacteria. In this disclosure the term "inhibiting" may include killing of bacteria.
Another object of the invention is provide compositions containing as an active constituent such polypeptides.
Yet another object of the invention is to provide a method of treatment directed to inhibition of bacterial growth in animals, in particular mammals including man.
For these and other objects which will be clear from the following disclosure the invention provides a polypeptide having the amino acid sequence: H.sub.2 N-Ser-Trp-Leu-Ser-Lys-Thr-Ala-Lys-Lys-Leu-Glu-Asn-Ser-Ala-Lys-Lys-Arg-Ile- Ser-Glu-Gly-Ile-Ala-Ile-Ala-Ile-Gln-Gly-Gly-Pro-Arg-COOH,
and the invention also includes functional derivatives such as a few conservative amino acid replacements and the C-terminal amide. The amidated form is the better antibiotic (Example 3).
The polypeptide of the present invention and its functional derivatives are all therapeutically useful, particularly as antibacterial agents. Thus, they are capable of inhibiting growth of bacteria, in particular gram-negative bacteria making them useful for different therapeutic purposes. This will be further illustrated by specific examples which are given below.
The active polypeptide according to the present invention can be formulated for use in human or veterniary medicine for therapeutic or prophylactic use. The active preparations are normally administered orally, reactally or by injection in the form of pharmaceutical preparation or composition comprising the active constituents in combination with a pharmaceutically acceptable carrier which may be solid, semi-solid or liquid, or contained in a capsule, such as when orally administrered. As examples of pharmaceutical preparations there may be mentioned tablets, drops, solutions and suppositories. Usually, the active constituent constitutes the minor part of the preparation, such as from about 0.1 to about 50% thereof based on weight.
In order to prepare pharmaceutical compositions in the form of dose units for oral application the polypeptide of the invention can be mixed with a solid, pulverulent or other carrier, for example lactose, saccharose, sorbitol, mannitol, starch, such as potato starch, corn starch, millopectine, cellulose derivative or gelatine, and may also include lubricants, such as magnesium or calcium stearate, or polyethylene glycol waxes compressed to the formation of tablets or bodies for dragees.
By using several layers of the carrier or diluent tablets operating with slow release can be prepared.
Liquid preparations for oral application or for injection can be made in the form of elixirs, syrups or suspensions, for example solutions containing from 0.1 to 20% by weight of active substance, sugar and a mixture of ethanol, water, glycerol, propylene, glycol and possibly other additives of a conventional nature.
The dose by which the active constituent is administered may vary within wide limits and is dependent on different factors, such as the seriousness of the disorder, the age and the weight of the patient and can be adjusted individually.
The invention also covers a method for therapeutic treatment of animals, such as mammals including man, said method comprising the step of administering a polypeptide as described above or a functional derivative thereof in an amount capable of inhibiting bacterial growth in said animal .
The present invention will now be further exemplified by specific examples which, however, are not to be construed as limiting the scope of the invention otherwise than according to the appended claims.
Preparation of a peptide concentrate
A concentrate of thermostable intestinal peptides was prepared from pig small intestine essentially as described elsewhere (Mutt, V. Arkiv Kemi 15, 69-74 (1959); Mutt, V. in Gut Hormones (ed. Bloom, S. R.), pp 21-27, (Churchill Livingstone, Edinburg, 1978).
Briefly, the uppermost meter of the intestine was immersed for 8.+-.1 min into boiling water and then cooled on ice and frozen. The frozen material was minced and extracted at 0.degree.-15.degree. C. with 0.5M acetic acid for 12 h and the mixture filtered with suction (with the aid of "Hyflo Super-Cel", 30 g per liter suspension). Peptides were adsorbed from the filtrate to alginic acid and the alginic acid carrying the peptides was washed in turn with 0.005M HCl, 95% ethanol (to remove (fats) and 0.005M HCl again. The peptides were eluted with 0.2M ice-cold HCl and the pH of the eluate was brought to 3.5.+-.0.1 with sodium acetate. Peptides were then precipitated by saturating the eluate with NaCl, and the precipitate was collected by suction filtration. The amount by weight of the precipitate (wet weight) is about one thousandth of that of the boiled intestinal tissue.
The concentrate was dissolved at room temperature to a 10% w/ve solution in water. Two volumes of 95% ethanol were added to the solution and the (apparent) pH (as measured with a glass electrode) of it was brought to 7.5.+-.0.1 with NaOH (1M NaOH:EtOH 1:2). A precipitate formed and was removed by filtration. To the clear solution one volume of 95% ethanol precooled to -20.degree. C. was added and the suspension was kept at this temperature for 24 h whereupon it was filtered. The peptides were recovered from the filtrate in aqueous solution and precipitated at pH 3.5.+-.0.1 by saturation of the solution with NaCl. The precipitate, collected by suction filtration, weighed about 10% of that of the concentrate taken for its preparation. It was dissolved in 0.2M AcOH and chromatographed in this solvent on Sephadex G-25 fine. The second half by volume of the peptide containing eluate from this chromatography was saturated with NaCl and the precipitate collected by suction filtration. Its weight was about 40% of that of the peptide precipitate taken for this chromatography. It was dissolved in water, the pH of the solution was adjusted to 4.+-.0.1 whereupon the peptides were reprecipitated with NaCl and the precipitate collected by suction (there was no significant difference in weight of the material before and after reciprecipitation). The reprecipitated material was extracted with methanol (50 ml/g) and the MeOH-insoluble fraction was collected by suction filtration and washed on the filter with water. The ether was evaporated in vacuo. The weight of the dry material was about 15% of that of the peptide precipitate taken for extraction with MeOH.
Purification of concentrate
As a starting material for the purification there was used the concentrate resulting from Example 1. The concentrate (1.5 g) was dissolved in 80 ml ammonium formate, pH 6.4, and treated with 30 ml of DEAE Sepharose, batch-wise.
Step 1: Chromatography on CM-Sepharose CL-6B (56 ml column, equilibrated with 0.1M ammonium formate, pH 6.4). Elution was initially carried out with 0.1M ammonium formate (about 2100 ml) to a low extinction and then gradient elution was performed using 0.1-0.85M ammonium acetate, pH 5.2 (300+300 ml). The activity leaves as an integral peak having a maximum at 0.38M, specific activity 30-40 units/.mu.g. (1 unit is defined as the activity of 1 ng of cecropin A.)
Step 2: Chromatography on an S Sepharose Fast Flow (26 ml column, equilibrated with 0.30M ammonium acetate, pH 5.2). The peak from Step 1 is diluted 1.3 times to about 0.3M and is applied to the column. Elution is initially carried out using 0.3M ammonium acetate (about 230 ml), then a gradient elution is performed with 3.30-0.50M ammonium acetate, pH 5.2 (300+300 ml). The activity leaves after the UV-material and the peak is eluated with 0.40M.
The peak material is freeze-dried, specific activity 200-400 units/.mu.g.
Step 3: FPLC on PepRPC (C2/C18 column). The peak from Step 2 is dissolved in 0.1% TFA in water. The material is applied to the column equilibrated with 0.1% TFA. Elution is first carried out with 0.1% TFA unti A.sub.214 decreases to the base line, and then complex gradient elution is performed: 0-5 min 0-29% CH.sub.3 CN, 5-45 min 19-48% CH.sub.3 CN, 45-50 min 48-100% CH.sub.3 CN. Many UV-peaks are observed but the activity is collected in 2-3 tubes eluted with 33% CH.sub.3 CN. The specific activity is estimated to be at least 700 units/.mu.g.
Step 4: Rechromatography in FPLC on PepRPC. The peak from Step 3 is diluted twice with water and applied to the same column. Elution is first carried with 0.1% TFA unit A.sub.214 decreases down to the base line, and then complex gradient elution is performed: 0-5 min 0-29% CH.sub.3 CN, 5-65 min 29-38% CH.sub.3 CN, 65-70 min 38-100% CH.sub.3 CN. Generally one UV-peak eluting with activity at 33% CH.sub.3 CN. Specific activity approximately 700-1200 units/.mu.g.
The purified peptide resulting from Step 4 was subjected to sequence analysis and mass spectroscopy. The amino acid sequence give above was confirmed.
The polypetide obtained in Example 2 was tested for antibacterial activity against different bacteria, the activity being given as lethal concentrations in micro-moles per liter (.mu.M). The results from the experiments are given in Table 1 below.
TABLE 1 ______________________________________ Antibacterial activities as lethal concentrations (.mu.M) for two synthetic forms of porcine cecropin P1C1. Organism and strain P1-NH.sub.2 P1-OH ______________________________________ Escherichia coli K12, D21 0.3 0.4 853/67, 0149, K88 0.9 0.6 Bd2221/75, O8, K88 0.6 0.7 Bd4462/84, O101, K99 0.7 0.8 Bd4468/84, O64, K99 0.3 0.6 Salmonella typhimurium, LT2 0.9 1.7 Acinetobacter calcoaceticus, Ac11 0.2 0.5 Proteus vulgaris, Pv11 5.7 12 Pseudomonas aeruginosa, OT97 5.9 13 Bacillus megaterium, Bm11 1.8 5.3 Streptococcus pyogenes 19 44 Staphylococcus aureus, Cowan 1 >490 >520 ______________________________________
The four last strains of E. coli were obtained from Olof Soderlind, SVA, Uppsala and they are clinical isolates that are pathogenic to piglets. Typing of O and K antigens are indicated after the strain number. Lethal concentration is the lowest concentration of cecropin that inhibits growth of the respective bacteria in thin agarose plates (see Hultmark, D. et al. EMCO J. 2, 571-576 (1983).
1. Polypeptides having the amino acid sequence: H.sub.2 N-Ser-Trp-Leu-Ser-Lys-Thr-Ala-Lys-Lys-Leu-Glu-Asn-Ser-Ala-Lys-Lys-Arg-Ile- Ser-Glu-Gly-Ile-Ala-Ile-Ala-Ile-Gln-Gly-Gly-Pro-Arg-COOH, and functional derivatives thereof consisting conservative amino acid replacements.
2. Polypeptides according to claim 1, in an underivatized form.
3. Polypeptides according to claim 1 in the form of an amide.
4. Polypeptides having the amino acid sequence: H.sub.2 N-Ser-Trp-Leu-Ser-Lys-Thr-Ala-Lys-Lys-Leu-Glu-Asn-Ser-Ala-Lys-Lys-Arg-Ile- Ser-Glu-Gly-Ile-Ala-Ile-Ala-Ile-Gln-Gly-Gly-Pro-Arg-COOH, and functional derivatives thereof consisting of comprising conservative amino acid replacements for therapeutic use.
5. Polypeptides having the amino acid sequence: H.sub.2 N-Ser-Trp-Leu-Ser-Lys-Thr-Ala-Lys-Lys-Leu-Glu-Asn-Ser-Ala-Lys-Lys-Arg-Ile- Ser-Glu-Gly-Ile-Ala-Ile-Ala-Ile-Gln-Gly-Gly-Pro-Arg-COOH, and functional derivatives thereof consisting of comprising conservative amino acid replacements for use as an antibacterial agent.
6. A pharmaceutical composition containing as an active constituent of the polypeptide according to claim 1 in an antibacterially effective amount together with a pharmaceutically acceptable carrier or diluent.
7. A pharmaceutical composition according to claim 6, wherein said carrier or diluent is acceptable for oral, intramuscular, intravenous or subcutaneous administration.
8. A method for inhibiting bacterial growth in animals, comprising the step of administering a polypeptide according to claim 1 in an inhibitory amount.
9. A method according to claim 8 for intestinal use comprising oral administration of said polypeptide in a slow release dose form.
10. A method according to claim 8, comprising administration by injection of said polypeptide in an injectable dose form.
11. A polypeptide having the amino acid sequence: H.sub.2 N-Ser-Trp-Leu-Ser-Lys-Thr-Ala-Lys-Lys-Leu-Glu-Asn-Ser-Ala-Lys-Lys-Arg-Ile- Ser-Glu-Gly-Ile-Ala-Ile-Ala-Ile-Gln-Gly-Gly-Pro-Arg-COOH for therapeutic use.
12. A polypeptide having the amino acid sequence: H.sub.2 N-Ser-Trp-Leu-Ser-Lys-Thr-Ala-Lys-Lys-Leu-Glu-Asn-Ser-Ala-Lys-Lys-Arg-Ile- Ser-Glu-Gly-Ile-Ala-Ile-Ala-Ile-Gln-Gly-Gly-Pro-Arg-COONH.sub.2 for therapeutic use.
13. A pharmaceutical composition containing as an active constituent the polypeptide according to claim 2 in an antibacterially effective amount together with a pharmaceutically acceptable carrier or diluent.
14. A pharmaceutical composition containing as an active constituent the polypeptide according to claim 3 in an antibacterially effect amount together with a pharmaceutically acceptable carrier or diluent.
15. A method for inhibiting bacterial growth in animals, comprising the step of administering a polypeptide according to claim 2 in an inhibitory amount.
16. A method for inhibiting bacterial growth in animals, comprising the step of administering a polypeptide according to claim 3 in an inhibitory amount.
17. A method according to claim 8, wherein said animal is a mammal.
18. A method according to claim 17, wherein said mammal is a man.
19. A method according to claim 15, where said animal is a mammal.
20. A method according to claim 19, wherein said mammal is a man.
21. A method according to claim 16, wherein said animal is a mammal.
22. A method according to claim 21, wherein said mammal is a man.
Filed: May 31, 1990
Date of Patent: Mar 17, 1992
Assignees: Kabigen AB (Stockholm), Skandigen AB (Stockholm)
Inventors: Hans G. Boman (Odengaten), Hans Jornvall (Vallstigen), Jong-Youn Lee (Stockholm,), Viktor Mutt (Solua)
Primary Examiner: John Doll
Assistant Examiner: Stephen Walsh
Law Firm: Burns, Doane, Swecker & Mathis
Application Number: 7/531,110
International Classification: A61K 3702; C07K 710; C07K 302; C07K 1300;

domain: chemistry


Evan Atar Adaha is honoured for his outstanding 20-year commitment in providing medical services to people forced to flee conflict.
Four generations of a Rohingya refugee family describe how statelessness has clouded their lives – and their hopes of returning to Myanmar.
Nine days on from the first eruption of Guatemala’s Volcan de Fuego, UNHCR, the UN Refugee Agency is concerned for the more than 1.7 million people now estimated to be affected by this humanitarian tragedy. According to official data as of yesterday, 12,784...
UNHCR dispatches over 1,300 emergency tents for families displaced by Sulawesi earthquake and tsunami
The UN refugee agency also calls for funds to aid survivors of the disaster
Displacement occurred at a rate of one person every 2 seconds
This is a summary of what was said by UNHCR spokesperson Andrej Mahecic – to whom quoted text may be attributed – at today’s press briefing at the Palais des Nations in Geneva.
Tens of thousands tune in to first ever TEDx in a refugee camp.
The UNHCR Special Envoy met with families who survived years of terror and displacement. Although the world seems to have forgotten them, they are determined to rebuild.
After recent visit to Bangladesh, Blanchett says more international support for displaced and host communities is urgently needed ahead of monsoon rains.


text:
Father: her father’s name is David. He is a computer technician.
Mother: her mother’s name is Guadalupe and she is a homemaker, who used to work in a kindergarten.
Siblings: she has two sisters named Leslie and Lynda.
Husbands: Jenifer was married 2 times. Her husbands were Ojani Noa and Marc Anthony.
Kids: Jennifer and Marc have twins, born in 2008. They are named Max and Emme.
Sexual orientation: straight
Jenifer dated many famous men and was married twice. Her first Celebrity date was Wesley Snipes (he dated him for about a year from 1994). In 1997 she fell in love with and quickly married the waiter Ojani Noa, who later threatened her to reveal her personal information. Later, she briefly dated Tommy Mottola, Rapper Diddy, and Dancer Cris Judd. In 2002 her famous relationship with Ben Affleck started – the two were even engaged but something went wrong. In 2004 she married singer Marc Anthony, stayed with him for about 6 years and gave birth to their two children. However, they divorced and JLo switched to a young Dancer. Her latest date is Rapper Drake.
Jennifer’s net worth is estimated $300m. She is one of the richest female performers alive.
Place of living: Jennifer owns several luxurious properties, including her mansions in California and NY.
Cars: Jennifer drives Aston Martin and Rolls Royce Ghost.
What was JLo’s childhood like?
Jenifer grew up in a relatively poor and loving family. From a very early age she was interested in acting and dancing. Also, she was academically successful.
What is her ethnic background?
Jennifer is of Puerto Rican origin.
What about that buttocks insurance?
JLo reportedly insured her iconic buttocks for $27m.
What are her most noticeable roles in movies?
Her most noticeable movies are “Money Train” (where she filmed her first sex scene), “Blood and Wine”, “Selena” (where she got the lead role), “Anaconda”, “U Turn”, “The Cell”, and “The Wedding Planner”.
What is her public image?
She is a renowned sex symbol, named the sexiest woman ever many times.
What is her music like?
Her music style is described as mix of pop and R&B with strong Latin and salsa influence.
What about her charitable activity?
She is a founder of Lopez Family Foundation – a charity fund that helps ill children. She has also donated money to many other charity organizations and events.

domain: artistic


When the editor forwarded the letter from Robert Mailer Anderson that appears on page 2, I thought for a split second that it was a belated apology. More than 25 years ago RMA had slandered me in these pages, called me an assassin, a Lee Harvey Oswald, because he assumed I was the Fred Gardner who had complained to the FBI in November, 1967, that Ramparts was publishing an article critical of the CIA by an author who had faked his bona fides. A (supposedly) former FBI man named William Turner had provided Ramparts publisher Warren Hinckle with a copy of a Bureau document referring to this Fred Gardner and his friend John Raymond as informants.
I could hardly blame Hinckle and others for not knowing there was a Fred Gardner who wrote for a paper called the Berkeley Gazette and was pals with John Raymond, who worked for Ramparts. (The other Fred Gardner had gotten a few bylines in the mid-60s when I was working at Scientific American in Manhattan. And his meeting with the feds took place when I was in South Carolina, setting up a coffeehouse that would be a haven for antiwar GIs and cause the feds considerable grief. That may be why they provided Turner with the old document. It has the feel of a dirty trick.)
While this mistaken identity case was unfolding, Bruce Anderson and I were in the midst of a bitter falling out and I had stopped writing for the AVA. I got word in advance of the attack R.M. Anderson had written and drove to San Rafael, where he was working in a bookstore, to explain that he was making a terrible mistake. He didn’t believe me and why should he have? My name was Fred Gardner, I had worked at Ramparts when I moved to the Bay Area in ‘66, I’d had a stormy relationship with Hinckle and had subsequently criticized Scheer in print. My being a snitch was a big story (in our small pond) and RMA was an ambitious young writer. Moreover, his uncle, the editor, assumed I was guilty as charged. And so the piece ran, and I remained estranged from the AVA for many years.
Fast forward to January 2023, when I was contacted by a journalist in Toronto who is writing a book about a once notorious ‘Frisco character named Anton LaVey. LaVey had known the other Fred Gardner and the Toronto journalist thought he’d reached a useful source. I explained the crazy situation to him and later found out from Peter Richardson, author of an excellent history of Ramparts that the fellow in Toronto hadn’t quite believed me and required more convincing from Richardson.
A few weeks ago I wrote about all this, and how I had finally identified the other Fred Gardner. (He had worked for 11 years at WGBH in Boston, another city where I once lived.) So I thought, when I saw the LTE from Robert Mailer Anderson, that he had read my update and wanted to make amends. No such luck. He was going on the warpath again because I had expressed admiration for Rep. Barbara Lee and dissed Adam Schiff, who is running to succeed Dianne Feinstein.
* * *
Here’s my response.
I stand by my song. After the 911 attacks on the Rockefellers’ World Trade Center and the Pentagon, Congress rushed through a $40 billion appropriation that authorized the Bush-Cheney-Rumsfeld Administration to use all “necessary and appropriate force” against anyone involved in any way with the attacks.
According to Bob Woodward’s book “Bush at War,” Rumsfeld insisted at a Cabinet meeting on the morning of Sept. 12 that Iraq should be “a principal target of the first round of terrorism.”
Adam Schiff should have known in 2001 – as Alex Cockburn’s readers did, and as Barbara Lee surely did – that the administration’s foreign policy was directed by neo-cons whose Project for the New American Century was demanding “the removal of Saddam from power.” The Project was run by Paul Wolfowitz, Rumsfeld’s #2 at the Pentagon, who had predicted in a 2000 report that Saddam’s downfall might be precipitated by “some catastrophic and catalyzing event, like a new Pearl Harbor.” Heck of a guess, Wolfie.
Underneath the Capitol dome
our so-called representatives
cheer their leader in the Andover sweater
yelling “Fight! Smite evil wherever it lives!”
They’ve got what’s called a gang mentality
‘Cept you Barbara Lee, just you Barbara Lee...
Where did Rep. Adam Schiff stand? According to Wikipedia: “Schiff voted in favor of the 2003 invasion of Iraq. In February 2015, discussing how or whether to tailor Bush-era plans from 2001 and 2002 to fight ISIS, Schiff was asked if he regretted voting to invade. He said: ‘Absolutely. Unfortunately, our intelligence was dead wrong on that, on Saddam at that time. The vote set in motion a cascading series of events which have [had] disastrous consequences.’”
Wikipedia also confirms the characterization of Schiff as a closeted neo-con: “In December 2016, he urged Obama to veto UN Security Council Resolution 2334, which condemned Israeli settlement building in the occupied Palestinian territories as a violation of international law.”
In 2019, when Rep. Ilhan Omar tweeted, “It’s all about the Benjamins baby” to decry US politicians’ obeisance to the Israel lobby, Schiff responded that it was “never acceptable to give voice to, or repeat, anti-Semitic smears.”
Robert Mailer Anderson is certainly correct that power in the US Senate is a function of seniority. This is from Robert Caro’s great biography of LBJ: “Seniority – not even mentioned in the original Senate rules, much less in the framers’ deliberations; not even a consideration during the first half century and more of the Senate’s existence– was in a way a child of slavery. That issue came to overshadow all others, so political parties had to be able to count on loyalty from senators who sat on the committees that dealt with its various aspects. In December, 1845, party caucuses took over the power of committee appointments within the Senate, passing resolutions that committees would be chaired by members of the majority party, that members of committees be carried over from Congress to Congress, that rank within each committee be determined by length of service in the Senate, and that the most senior member of the majority party would automatically become chairman. Thereafter, party caucuses drew up lists of committee appointments; the Senate as a whole simply accepted them. A senator’s rank on a committee was therefore determined by one qualification, and one alone: how long he had sat on it.”
Among the California Democrats hoping to succeed Dianne Feinstein in the Senate, the one most likely to gain clout via seniority is 49-year-old Katie Porter. Assuming your wonderful system lasts that long.
The piece that offended RMA contained a factual error he didn’t nail me for. I’d been misled by a Chronicle headline and a Joe Garofoli piece into thinking that Barbara Lee had formally announced that she was running for Feinstein’s seat. She has only signaled an intention to do so. Maybe Nancy Pelosi’s swift endorsement of Schiff (which got a banner headline in the Chronicle) was an attempt to dissuade Lee or prospective donors to her campaign.
(To hear the song that caused the latest round of trouble, Google “youtube Just you, Barbara Lee”)
“I’d been misled by a Chronicle headline and a Joe Garofoli piece…”?
Perhaps it’s best not to believe everything you read, or write.


Dickson denies rift with Diri, restates commitment to PDP
Former governor of Bayelsa State and Senator representing Bayelsa West, Henry Seriake Dickson has denied having rift with his successor, Governor Douye Diri over the administration of the state.
Dickson, who declared this at a grand reception by leaders of the Peoples Democratic Party (PDP) in Bayelsa West at Sagbama Council, maintained that the PDP in the state remain united.
Others honoured at the event include Diri, Deputy Governor, Lawrence Ehruwajakpor and representative of Sagbama/Ekeremor Federal constituency, Fredrick Agbedi.
The former governor said he deliberately maintained a distance from the incumbent administration, because he desired to give his successor a respectable distance to operate with discretion.
Dickson told party supporters, who defied the heavy rainfall to attend the reception, that he was constantly in touch with Diri, especially on issues of development in the state.
He also recalled how the PDP emerged victorious in the last governorship election and expressed the hope that the party would continue to win future elections in the state.
Responding, Diri declared that the PDP remained the party of choice for Bayelsa people and that it would be difficult to beat the party in any election in the state.
The governor, who noted that the party was firmly rooted in the state and had embarked on projects that have endeared it to the people, urged the people of Bayelsa West to close ranks and consolidate on the party’s achievements.


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In a lengthy Instagram post, the singer laments the lack of control she had over her career during her 13-year conservatorship.
Don’t plan on seeing Britney Spears perform anytime soon. The singer wrote a lengthy Instagram post on Sunday in which she looked back on her 13 years in the conservatory and said she “probably never performs again.”
Spears began the post by bemoaning her lack of creative control over the music videos she released during that time period (she claims the only one from that period she liked) and her unpleasant experience working with photographers. The post primarily targeted her father, Jamie Spears, who oversaw the pop singer’s estate from 2008 to 2021, in a typical fashion.
“…[T]he most offensive SO CALLED professional pictures on every tour. I mean they could have at least cheated and retouched them for me … just saying … 2 day shoots for new show in Vegas literally the worst ever … and me excited for the pictures for 5 months on tour … they never showed me any,” she wrote alongside a (literal) cheeky photo. “I’d rather quit shit in my pool and shoot photos of myself in studios over working with the most offensive people in my life.”
Spears said her past experiences left her “traumatized” and uncertain of whether she will ever perform on stage again, adding that she was uncomfortable with the number of dancers she was required to perform with on stage during her four-year Las Vegas residency. (She last gave a live performance on the final night of her residency in 2017.)
“I’m pretty traumatized for life and yes I’m pissed as fuck and no I won’t probably perform again just because I’m stubborn and I will make my point,” she said before closing out with a simple “kiss my God damn mother fucking ass.”
Spears has previously discussed the possibility of giving up live performances, but this is the first time she has brought it up since the conclusion of her conservatory.
Spears recently made her official comeback to music with “Hold Me Closer,” a disco-infused reworking of some of Elton John’s classics, even though she may not be planning a world tour anytime soon. Her first new song since her 2016 album Glory, the song also included Elton John.
At the time, after years of legal issues, Spears’ attorney Mathew Rosengart praised the pop star for her triumphant comeback. “After our hard-fought court battles and success in removing her father as conservator and then the termination of the conservatorship last year, I was inundated with inquiries about what Britney would do next,” he told in a statement. “My response was simple: ‘For the first time in 13 years, that is up to one person and one person only: Britney. Britney is a brilliant artist and iconic person.”


Inbox advertising, that is, the display of advertising messages in a form similar to a real email in an inbox, should be considered as use of the email for the purposes of direct marketing, the Court of Justice of the European Union (CJEU) recently asserted.
This means that any such advertising must comply with EU rules governing direct marketing.
The EU Directive on privacy and electronic communications provides that the use of automatic calling machines, facsimiles or e-mails for direct marketing purposes may only be authorized with regard to subscribers having given their prior consent.
Another EU law, namely the EU Directive on Unfair Commercial Practices by Businesses to Consumers, prohibits as an aggressive business practice the making of persistent and unwanted solicitations by telephone, fax, e-mail or other remote supports.
The facts of this case were briefly as follows.
An electricity supplier asked an advertising agency to run advertisements that consist of displaying banners in the email inboxes of users of a free email service supported by paid advertising by advertisers.
These messages appeared as soon as users of the e-mail service opened their inbox. The affected users and the messages displayed were chosen at random.
These emails were not visually distinguishable from the list of other emails in the user’s account, except that the date was replaced with the word “advertisement”, no sender was mentioned and the text appeared on a gray background.
The “subject matter” section contained text intended to promote advantageous prices for electricity and gas services.
A competing electricity supplier brought an action in national courts asking its competitor to refrain from such an advertising practice, alleging that such a practice was a form of unfair competition.
The CJEU asserted that inbox advertising could be considered a form of “persistent and unwanted solicitation”, within the meaning of the law.
The court of first instance ruled in favor of the applicant. On appeal, the Court of Appeal lodged a preliminary ruling before the CJEU asking for advice on whether and, if so, under what conditions, advertising in inboxes can be considered compatible with the law. of the EU.
The CJEU observed that the main objective of the EU Directive on privacy and electronic communications is to protect subscribers against intrusion into their privacy through unsolicited communications for direct marketing purposes, in particular through the use of automated calling machines, faxes and electronic mail, including SMS.
Such an objective must be preserved whatever the technologies used. Hence the importance of adopting a broad interpretation when considering the technological perspective of the type of communications covered by the Directive, said the Court.
The CJEU considered the modes of distribution used by the advertising agency for the advertisements in question as a use of electronic mail likely to undermine the objective of protecting users against any intrusion into their privacy by unsolicited communications for purposes direct marketing.
The very nature of the advertisements promoting the Services, and the fact that they are delivered in the form of an e-mail, argues in favor of classifying these messages as “communications for marketing purposes. direct ”.
The fact that the recipient of the advertising messages is chosen at random is irrelevant, the court said. What matters is that there is a communication for commercial purposes, which directly and individually affects one or more users of the messaging service.
The court then proceeded to analyze the element of “consent”. She noted that the use of e-mails for direct marketing purposes is authorized, provided that the recipient has given his prior consent.
Such consent must be a free, specific and informed will on the part of the person concerned, the court said.
The CJEU noted that it is for the national court to verify whether the user concerned, having opted for the free electronic messaging service T-online financed specifically by advertising, has been duly informed of the precise means of dissemination of this advertising. , and in fact actually consented to receive advertising messages.
In conclusion, the CJEU asserted that inbox advertising could also be considered a form of “persistent and unwanted solicitation” within the meaning of the law. This is the case if the display of such advertising messages is frequent and regular enough to be classified as “persistent” and “undesirable”, if the user has not given his prior consent to this display.
The rigid approach adopted by the EU towards the protection of the privacy of individuals is evidenced by the broad interpretation of legislative measures adopted specifically for this purpose, in particular the GDPR and the Privacy Directive and electronic communications.
Indeed, it is only by such an interpretation that any legislative measure adopted for this purpose can adapt to the times and resist the rapid changes in technology in order to grasp the innovative ways and means by which the law of an individual’s privacy may be violated.
Independent journalism costs money. Times of Malta support for the price of a coffee.


text:
BP plc says the chemical recycling project in Naperville, Illinois, Wants focus on hard-to-recycle objects.
BP plc wants to build a $25m (€22.5m) pilot plant in Naperville, Illinois, To transform what it calls unrecyclable PET into "virgin-quality feedstocks."
The new chemical recycling facility, showcasing a technology called BP Infinia, has an end of diverting plastic waste from landfills and incineration.
Tufan Erginbilgic, chief executive of a BP, said: "We see Infinia technology as a game changer for the recycling of PET plastics unit called Downstream.
The technology "involves chemically converting complex PET plastic waste back to original monomer feedstocks through a depolymerisation process," the company reported.
The process aims to purify the monomer into recycled terephthalic acid and recycled monoethylene glycol "which said," BP said.
The technology looks to capture difficult-to-recycle PET, including black food trays and coloured bottles, for example, in a process that would allow repeated recycling.
The pilot plans to be located at the company's research and development hub in Naperville and open in late 2020.
"BP sees the potential to develop multiple full-scale commercial plants using this technology around the world," the company said. "If deployed at scale in a number of facilities, BP estimates that the technology has the potential to prevent PET bottles and trays from ending up in landfill or incineration every year."
Environmental group Greenpeace was unimpressed with the announcement.
Greenpeace Oceans Campaign Director, John Hocevar, said: "BP Infinia wants to do away with the plastic pollution said in a statement.


Klawock Husband And Wife Plead Guilty To Willful Failure To Pay Taxes
June 01, 2018
According to court documents, Archie W. Demmert III, 57, and Roseann L. Demmert, 60, both of Klawock, Alaska, held commercial fishing permits and earned six-figure incomes in 2013 and 2014 from commercial fishing, on which they failed to timely pay the required income taxes due.
In addition, according to court documents, from 2006 to 2012 the Demmerts also did not timely pay in full the taxes they owed to the Internal Revenue Service. As a result, the total tax loss to the IRS arising from their conduct is more than $300,000.
When charged in July 2017, the Justice Department alleged the Demmerts did not pay their taxes for 13 separate tax years, for which they owed over $400,000, excluding penalties and interest. The amount of taxes owed and restitution will be known at the time of sentencing in October.
Chief U.S. District Judge Timothy M. Burgess scheduled sentencing for October 4, 2018. The Demmerts each face a statutory maximum sentence of two years in prison, as well as a period of supervised release, restitution and monetary penalties.
Principal Deputy Assistant Attorney General Zuckerman and U.S. Attorney Schroder thanked special agents of IRS Criminal Investigation, who conducted the investigation, and Tax Division Trial Attorney Lori Hendrickson and Assistant U.S. Attorney Andrea Steward who are prosecuting the case. Defense attorneys Kevin Higgins and Paul Grant represented Archie and Roseann, respectively
Editing by Mary Kauffman, SitNews
Source of News:
Representations of fact and opinions in comments posted are solely those of the individual posters and do not represent the opinions of Sitnews.


text:
Banana Pudding Cupcakes Recipe from Kimberly Laidman. I don't like banana pudding personally but my family can't get enough of it. I will have to try this!
Impossible Pumpkin Pie Cupcakes
Strawberry Cupcakes with Strawberry Cream Cheese Frosting
Dollhouse Bake Shoppe: Easy Thanksgiving Cupcake Toppers

domain: food


text:
Monthly Archives: July 2010
Chail : When Bhupinder Singh, Maharaja of Patiala,was expelled from Shimla – the `summer capital’ of the British in India – he decided to create his own capital for the hot months. The little village of Chail was perfect. It lay surrounded by magnificent deodar forests, Shimla was in direct vision and
most important, the hill of Chail at 2226 m was somewhat higher than British-controlled Shimla. Today the Maharaja’s creation can be experienced by everyone. Whether you are on a honeymoon or in search of seclusion or wish to organise a conference and demand all facilities, Chail has it all .
Then, there is good sight seeing and the possibility of some fishing and trekking. Chail also has the world’s highest cricket pitch and polo ground.
Machan-like sighting posts have been built near Blossom and at Khariun.
with breathtaking view.
Trails Iead upto the Choor Peak and to Shimla. Skiing can be done at Narkanda during winters. There is fishing on the Giri river at Gaura , 29km away.
By Road : Chail is connected by road. From Shimla via Kufri the distance is 45 km and via Kandaghat this is 61 km. Kalka is 86 km away. Regular buses for Chail leave from Shimla, Chandigarh and Delhi.
drop below freezing point when heavy woollens are required. In summer the climate is mild and light woollens/cottons are recommended.
fascinating in autumn when the fields and the forests are covered with a cloak of russet and gold and, of course, in winter it is nothing less than paradise. Everything about this place is as perfect as perfection can possibly be. The air here is crisp, invigorating and there is some kind of warmth in the snow.
Vikas Nigam (GMVN) offers a fortnight-long skiing course for the amateurs. There is also a weeklong course for the tourists.
chair, which also has a storm-warning device attached to it. Another comfortable scientific contribution to this highland is a state-of-the-art ski lift.
Auli has a string of GMVN guest houses at strategic points, with reasonable tariff rates for lodging and boarding. Private accommodation and campsites are also available.
to take overnight train from Delhi and have a cab pick you up from Haridwar in the morning for onward journey to Auli.
km from Rishikesh.
By road: Auli is only 13 km drive from Joshimath. State transport and Union buses play regularly between Joshimath and Rishikesh (253 km). Local Transport Union Buses and State Transport buses operate between Joshimath and Rishikesh (253 km), Haridwar (277 km),
Dehradun (298 km) and Delhi (500 km). From Joshimath onwards, both bus and taxi services are available for Auli.
When to Go
Auli can be traveled round the year. but its better to plan your tour between, December to March as this is the most ideal time for all visitors.
Almora: Picturesque district of Almora is a fine blend of mountain beauty; ancient cultural influences, sanctified spots, thickly wooded forests, scenic valleys, quaint cottages, crystal lakes and gushing rivers…… all inspiring one to call it the ‘Switzerland of India’.
Almora is a hill district in the central Kumaon region of Uttaranchal. It is a beautiful scenic place situated at an altitude of 5900 ft.
range in between the river Kosi and Suyal There is a cave where Swami Vivekanand meditated and was enlightened. Almora was captured by British from Gorkhas, who have left their mark on this town. Nanda Devi festival is celebrated here, during which devotees from all over India visit this place.
Sight Seeing: Nearby places of tourist interest where an excursion can be made within a day are Bright End Corner’s unforgettable sunset, Chitai temple with it’s unique collection of brass bells of all sizes, gifted to the temple by devotees since centuries,
Kasar Devi which houses many Europeans who fell in love with the place so much that they settle down, Nanda Devi Temple the cultural and religious center of Almora for now hundreds of years and Lala Bazaar a unique market of more than two hundred years with paved streets of stone.
Bright End Corner: Almora is 2 kms away from here. A highlight of this point is the sunset and the sunrise seen through the Himalayan peaks. A circuit house close by allows tourists to spend some time in this peaceful surrounding. Close by is the Vivekanand
Library which has many books on literature. A little away is the Vivekanand Memorial where Swami Vivekanand had stopped for a while on his journey to the Himalayas.
Most of the people who live here are foreigners. Buses and taxis come up to a point called Panuwanaula and from there onwards one has to walk.
3 kms from Almora this park is in NTD (Narayan Tiwari Dewai).
State Museum: This museum is near the bus stand . It is closed on Mondays and other Government Holidays. It is open from 10:30 A.M. to 4:30 P.M.
The people of Kumaon worship him. Once a wish is fulfilled people hang little bells in this temple. Therefore there are thousands of little bells hanging there. The view of the Himalayas is extremely beautiful from here. This temple is 8 kms away by walk through a beautiful pine forest, but one can go by cart too.
This 800-year old Sun Temple is the second in importance after the Sun Temple of Konark in Orissa. Seven kms away from Almora this historical important temple is an example of intricate sculpturing. This temple is in need of restoration now.
30 kms from Almora Binsar has a temple of Shiva who is also called Bineswar. 2412 mts above sea level this temple was constructed by King Kalyan of the Chand Dynasty. Visiting this temple gives one peace of mind.
34 kms away from Almora this temple of Shiva is situated amidst a dense Deodar forest and has a lot of mythological importance. Here there are about 164 temples of this kind.
This 1000-year old temple is one of the main attraction of Almora. Its walls have carvings on them. Every year a festival is held here in which youth from various mountainous areas come here to participate in this dance festival.
47 kms from Almora this is an ancient Shiva temple with natural caves. 2116 mts above sea level this place is a favourite with nature lovers.
Near Kalimutt is the temple of Kasar Devi.
This ancient temple was built on a mountain peak in the second century. The distance between Kalimatt and Kasar Devi is less than 1 km and can be easily covered by foot. The surrounding area has become the home of many foreigners. The main town is 6 km away.
Road : Connected by road with most places of Uttaranchal
Distance from Almora:

domain: geography


text:
The Gainesville Police Department (GPD) announced that detectives have arrested a student in connection with the Gainesville High School (GHS) bomb threat on Wednesday.
“Detectives received tips from School Resource Officers and students the following day and were able to develop probable cause for the arrest,” GPD reported in a Facebook post. “The suspect is currently being held at the Juvenile Detention Center pending a detention hearing.”
GPD did not name the student suspect but noted the person is a minor facing charges of “false report concerning planting a bomb, an explosive, or a weapon of mass destruction” and “unlawful use of a two-way communications device.”
GPD personnel responded to GHS on Wednesday after someone called in a bomb threat to a school office. Officers cleared the area and found nothing suspicious, but official sent students home for the day.
“Traffic was tied up for hours during the evacuation and clearing of the school, as well as many cumulative hours of GPD resources used in assisting,” the GPD Facebook post said.
GHS received a second bomb threat on Thursday, but the GPD statement did not link it to the unidentified student arrested Friday.
ACPS schools have experienced 13 bomb threats since the start of the school year, including four at Buchholz High School, four at Newberry High School, one at Eastside High School, one at Oak View Middle School and one at Newberry Elementary School.
The Friday arrest marks the fourth in the ongoing investigations, which have included FBI support. Authorities arrested 17-year-old Buchholz High School student Preston Powers on Sept. 13 in connection to two of the Buchholz threats, and Alachua County Sheriff Clovis Watson announced that the teen would be prosecuted as an adult.
On Thursday Alachua County Sheriff’s Office deputies took two students into custody in connection with the Newberry incidents, which included six bomb threats and at least two sniper threats.


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Even while you’re retired, some issues are too journalistically offensive to let move, comparable to this piece of absolute rubbish we simply noticed from The Nationwide right this moment.
The paper’s nameless reporter set off all our purple warning lights directly.
Right here’s an alertness take a look at for you, readers: see in the event you can see what’s lacking from this “debunk” of Dowey’s declare.
Did you (fail to) spot them? Strikingly absent from the piece are any numbers to again up “The Jouker” and Ross Greer’s declare that Dowey was improper. And that solely makes one sound, people: BULLSHIT KLAXON! BULLSHIT KLAXON! ALL HANDS ON DECK!
So let’s fill within the gaps, we could?
So far as we will decide, six pro-independence events stood within the election within the constituency poll, the listing poll or each: the SNP, the Scottish Greens, Alba, Scotia Future, the Libertarian Get together, and Restore Scotland, with the final three of these additionally being pro-Brexit events.
(Each different social gathering was both explicitly anti-independence – Labour, Tories, Lib Dems, All For Unity, Impartial Inexperienced Voice, Abolish The Scottish Parliament, Reform UK, UKIP, Communist, Reclaim, SDP – or within the case of a few tiny fringe events had no acknowledged view and due to this fact supported the established order by default. The Scottish Household Get together, for instance, who bought 18,819 votes, the biggest of the microparties, stated they have been impartial on independence itself however have been opposed to a different referendum on this Parliament, which is de facto Unionist.)
These are their votes:
Restore Scotland 1,192
Scotia Future 1,032
(Complete: 1,330,331 out of 2,706,761 constituency votes, or 49.2%.)
Restore Scotland 1,149
Scotia Future 451
(Complete: 1,366,198 out of 2,712,783 listing votes, or 50.4%.)
So “The Jouker” is kind of appropriate of their assertion that Unionists gained the constituency vote however pro-indy events gained the listing. All we have to do now, then, is whole them as much as see who gained general.
The figures above present that the six pro-indy events bought a complete of 2,696,529 votes out of a complete of 5,419,544 legitimate votes solid within the election. Inconveniently for “The Jouker”, that’s 49.8%. Dowey is appropriate. The Unionists gained.
Professional-indy events would have wanted 2,709,773 votes in whole to get 50%+1. That’s 13,244 brief. Even when we attributed each vote for unbiased candidates to the pro-indy facet (and we’ve no grounds for doing so), that solely provides 11,795 – not sufficient.
Alternatively, in the event you bend over backwards to attempt to assist “The Jouker” out by eradicating the events who explicitly stated they have been impartial on independence and/or a referendum (Ladies’s Equality and Freedom Alliance), pro-indy events get 2,696,529 out of 5,410,223 votes (nonetheless 49.8%).
The article is just a lie. No matter your opinion on independence, it’s piss-poor journalism and even The Nationwide needs to be ashamed of it.
(It later transpired that Greer had made a crooked depend, including up the votes of solely 5 of the 26 events who stood within the election – 12 of whom contested each area. His figures discounted a complete of 133,175 votes for events who had a acknowledged place on independence and/or a second referendum by some means.)
One of many classes we’ve tried to drum into Wings readers for the final decade is to all the time, all the time, search for what you’re not being instructed. And an article about numbers that doesn’t have any numbers in it’s about as simple as that job will get.

domain: politics


text:
HOW MUCH DOES A DESIGN COST?
There are a number of criteria which will determine the design costs. For instance, the amount of work involved in the design process and design complexity. The fees listed below are to be used as a guide only and will be discussed with you in more detail upon a consultation.
BRONZE STANDARD DESIGN SERVICE
Design fee starts from £600.00. This would cover a relatively flat, small garden of approximately 30-200m2 with a build budget of £15,000-£20,000 plus VAT.
Design fee will include site survey, levels survey and any plotting. You will receive a Design Concept Plan (Masterplan) and a Construction Specification.
SILVER STANDARD DESIGN SERVICE
Design fee starts from £900.00. This category is for larger gardens of 200-500m2 with a build budget starting from £20,000 plus VAT. All services mentioned in the Bronze Standard Design Service are included.
GOLD STANDARD DESIGN SERVICE
Design fees to be discussed. This category is for gardens of in excess of 500m2 with a build budget of in excess of £30,000 plus VAT. All services mentioned in the Bronze Service. Additional detailed drawings may be required for construction, water feature design, garden structures and lighting design.
Depending upon the size and topography of your garden, the services of a qualified Land Surveyor may be required the costs being met by you directly.

domain: design


|Subject: AFP: Reinado's lawyer denies
Indonesia asylum bid
Agence France Presse
June 2, 2007
Reinado's lawyer denies Indonesia asylum bid
DILI, June 2 2007
The lawyer of fugitive East Timor rebel Major Alfredo Reinado denied reports Saturday that his client has flown to Indonesia to seek asylum.
But Benevides Correia said he had not had any contact with his client since Sunday.
"I can say that the rumours saying that Reinado sought political asylum are untrue," Correia told AFP of the report in the Voice of East Timor newspaper.
"He disappeared since his appearance on Metro TV. I haven't had contact with him since then. We usually made daily contact," he said.
Reinado appeared on television Sunday, raising questions about his location.
Reinado, who commands support from frustrated groups from East Timor's west, had earlier indicated he was ready to lay down his weapons and give himself up.
He has been on the run since Australian-led troops attacked his mountain hideout in March, killing five of his armed supporters in a failed offensive.
The fugitive has previously been blamed in part for last year's unrest, after he and others led 600 soldiers to desert the army over claims of discrimination.
The soldiers were sacked by the then prime minister, sparking firefights between factions of the military that degenerated into gang violence.
At least 37 people were killed, another 150,000 displaced and Australian-led international peacekeepers were dispatched to restore security.
The government approved the manhunt in February after Reinado attacked several border police outposts and fled with dozens of weapons.


text:
A Vermont man has been fired from his job at a pizza restaurant after participating in the recent white supremacist rally in Charlottesville, Virginia
From The New York Times: Native Americans challenge their invisibility in society.By: By MICHÈLE STEPHENSON and BRIAN YOUNG. Watch the original video on Times Video: https://nyti.ms/2uYVXHC
One of the scientists who helped design maps to show Earth’s location 40 years ago, is saying they could be dangerous for humankind. Jose Sepulveda (@josesepulvedatv) has more.
Survey finds Russian President Vladimir Putin is more trusted than President Donald Trump to do the right thing in global affairs by citizens of numerous U.S. allies, including Japan, South Korea and seven European NATO members
An investigation prompted by a Connecticut fire chief's refusal to hang a photograph of the department's first black chief on a wall of honor faulted him for racial insensitivity
Police say an arrest has been made in connection with the shooting death of a 7-year-old Kentucky boy who was shot in the head by a stray bullet as he ate cake at his kitchen table
Confederate monuments in Baltimore were quietly removed and hauled away on trucks in darkness early Wednesday, days after a violent white nationalist rally in Virginia that was sparked by plans to take down a similar statue there


text:
eSports betting platform Luckbox now supports crypto deposits
- A popular eSports betting platform, Luckbox, recently announced that its users can now make crypto deposits in 4 different digital currencies.
- The move was made due to the increased demand for crypto payments across the iGaming industry.
- Furthermore, the platform is planning to release its native crypto, LuckCash (LCK), later in 2020.
While digital currencies are constantly expanding and entering nearly every industry around the world, betting and gambling still appear to be their strongest use cases. The fact that yet another well-known betting platform has added crypto as a payment method is proof of this. The platform in question is Luckbox, a licensed eSports betting site that announced that its users can now make crypto deposits. Luckbox added support for four different cryptocurrencies at this time, including Bitcoin, Ethereum, XRP, and Litecoin. Apart from adding crypto deposit support, the platform recently also added eSports stats to its match pages, as well as live streams in different languages. Now, eSports fans can use Luckbox to bet real money in over 100 different regions of the world. At the moment, the platform has a number of leading games, including Dota 2, CS: GO, Overwatch, League of Legends, and many others.

domain: game


text:
Capability Maturity Model, The: Guidelines for Improving the Software Process, 1st edition
Unfortunately, this item is not available in your country.
Principal Contributors and Editors:
Mark C. Paulk, Charles V. Weber, Bill Curtis, Mary Beth Chrissis
"In every sense, the CMM represents the best thinking in the field today... this book is targeted at anyone involved in improving the software process, including members of assessment or evaluation teams, members of software engineering process groups, software managers, and software practitioners..." From the Foreword by Watts Humphrey
The Capability Maturity Model for Software (CMM) is a framework that demonstrates the key elements of an effective software process. The CMM describes an evolutionary improvement path for software development from an ad hoc, immature process to a mature, disciplined process, in a path laid out in five levels. When using the CMM, software professionals in government and industry can develop and improve their ability to identify, adopt, and use sound management and technical practices for delivering quality software on schedule and at a reasonable cost.
This book provides a description and technical overview of the CMM, along with guidelines for improving software process management overall. It is a sequel to Watts Humphrey's important work,Managing the Software Process,in that it structures the maturity framework presented in that book more formally.Features:
- Compares the CMM with ISO 9001
- Provides an overview of ISO's SPICE project, which is developing international standards for software process improvement and capability determination
- Presents a case study of IBM Houston's Space Shuttle project, which is frequently referred to as being at Level 5
Table of contents
I. THE CAPABILITY MATURITY MODEL FOR SOFTWARE: BACKGROUND, CONCEPTS, STRUCTURES AND USAGE.
II. THE KEY PRACTICES OF THE CAPABILITY MATURITY MODEL FOR SOFTWARE.
Published by Addison-Wesley Professional (June 19th 1995) - Copyright © 1995

domain: library


text:
Longo Mai's Finca Sonador in Costa Rica
Six years ago when I visited the intentional community Ganas in Staten Island, I heard about Long Mai in France. A few months later I was in France I visited Longo Mai, and I heard about their project Finca Sonador in Costa Rica. So when I visited Costa Rica, I made it a point to visit Longo Mai's Finca Sonador.
Finca Sonador is an 800-hectare farm bought originally with funds from the French Community. It's on the road from Perez Zeledon to Buenos Aires (you can ask the bus driver to drop you off at the entrance then walk in about one kilometer on a good dirt road).
I was only there for a few days. I observed sugar cane harvest, and I stayed in a house owned by a family who had once been refugees from El Salvador. Although there were a few people from the French Long Mai, basically the land had been donated to a new organization focused on providing homes for refugees from Central American countries in the late 70s and early 80s. The families cannot sell their land, but they also have the right to stay there.
It's less than ten US dollars a day to do a homestay there. I enjoyed my visit there. You might enjoy spending some time there also.

domain: sociology


text:
State-Of-The-Art Lab Space in Basel
Switzerland Innovation Park offers lab space for rent in the Baselarea. The perfect location for existing science and technology companies looking to expand, or start-up companies and later stage companies seeking an entrepreneurial base for their laboratory work.
At our Main Campus, we are operating a fully equipped, shared lab space available to rent. The space is tailored for companies operating in a wet lab biology and chemistry environment doing drug discovery, diagnostics, synthetic biology and related work.
Current residents include biotech and medtech superstars, working on developing breakthrough innovations that will change the landscape.Current Residents
All our lab spaces are fully permitted and managed by an onsite dedicated lab manager, taking care of everything from equipment maintenance and relevant permits to safety procedures, waste management, and introductions to the various equipment.
Depending on specific needs needs, startups and companies can rent one or more benches at a time, with access to:
- Facility Management
- Shakers, incubators and autoclaves
- Fridges, freezers, ice machines and liquid nitrogen tanks
- PCR and qPCR machines
- Various plate readers, imaging stations, and microscopes
- HPLCs, rotavaps and chemical hoods
- Cell culture facilities (up to BSL-2 safety levels)
- Centrifuges, thermomixers, orbital shakers & rockers, nucleic acid & protein electrophoresis equipment and more
Learn more about renting a lab in Switzerland
Switzerland Innovation Park Basel Area focuses on four specific thematic areas for research and subsequent development into products and services. Residents who rent our lab spaces benefit from the huge potential for innovation in biotech, medtech, digital health, healthtech and industrial transformation.
In the area of biotech, research is focused on drug development and discovery. Our residents work on breakthrough treatments that offer greater benefits than just incremental improvements. Most companies are in the process of discovering, developing and testing their products with the goal of fulfilling unmet medical needs – they aim at addressing conditions for which there are currently no adequate cures or diagnoses.
Medtech companies at Switzerland Innovation Park Basel Area work on innovations, tools, materials or objects that will change diagnosis, monitoring, therapeutics or treatment. Switzerland is one of the most important locations for the global medical technology industry with the highest density of medical device companies per capita in Europe – and the Basel Area is its most dynamic center of activities.
Digital Health & Healthcare
The Basel Area is a world-leading hub of biopharma, diagnostics and medtech industries. These players are in the midst of the transformation of their business models, traditionally focused on drugs and devices, towards the delivery of healthcare. This is accompanied by the rapid adoption and development of Digital Health and Healthtech capabilities, making the Basel Area a hotbed in these fields.
The Basel region boasts a solid base of manufacturing companies (from large to SME). The canton of Basel-Land is particularly active in production for the chemical and pharmaceutical industries, while the canton of Jura is a hotspot in the field of watchmaking.
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Warning from British scientists to the world
Despite these genomic accomplishments, some British scientists said they have regrets too, wishing they’d known just how rapidly SARS-CoV-2 was actually spreading a year ago, when it hit western Europe.
That information was crucial not only for preventive efforts, but because viruses inevitably mutate faster the more people who are infected, said Igor Rudan, MD, PhD, director of the Center for Global Health Research at University of Edinburgh.
“Italy showed us just how fast it was spreading and how deadly it is for the very old and people with multiple comorbidities,” said Dr. Rudan, who also editor in chief of the Journal of Global Health. “We wish we knew it was spreading so fast, and we wish we knew the threshold of cases we could allow to be infected before the virus would mutate.”
More mutations mean more new strains of SARS-CoV-2, Dr. Rudan said in an interview. “We’ve reached that threshold now and will see more of these mutations.”
Despite its current struggles, the United Kingdom is reaching beyond tracking its new variant’s spread and trying to identify new mutations that might change the way the virus behaves.
Three features of any emerging variant are particularly important, Dr. Peacock explained: Is it more transmissible? Is it more lethal? And does it cut the ability of natural- or vaccine-induced immunity to protect people from infection?
“We need to sequence people coming to the hospital who are sicker,” said Dr. Peacock, also a professor of public health and microbiology at the University of Cambridge (England). “Also, if anyone has the infection after they’ve already been sick or had the vaccine, we really want to know what that looks like” genomically.
SARS-CoV-2 has already logged more than 4,000 mutations, Dr. Peacock said. But “knowing that viruses mutate all the time is not sufficient reason not to look. We really want to know if mutations lead to changes in amino acids, and if that can lead to changes in functionality.”
For the moment, however, experts say they’re relieved that the U.K. strain doesn’t seem able to evade COVID-19 vaccines or render them less effective.
“Even though mutations are common, those able to change the viral coding are rare,” Dr. Brito explained. If necessary, vaccines could be tweaked to replace the spike gene sequence “within a matter of weeks. We already do this for flu vaccines. Every year, we have to monitor variants of the virus circulating to develop a vaccine that covers most of them. If we end up having to do it for SARS-CoV-2, I would not be surprised.”
But variant-fueled increases in infections will require more people to be vaccinated before herd immunity can be achieved, Dr. Rudan warned. “If it spreads faster, we’ll need to vaccinate probably 85% of people versus 70% to reach herd immunity.”
One lesson the COVID-19 pandemic has driven home “is to always be on your guard about what happens next,” Dr. Peacock said. Although confident about the genomic efforts in the United Kingdom to date, she and her colleagues feel they’re still reaching for a complete understanding of the evolutionary changes of the virus.
“We’re ahead of the curve right now, but we want to get in front of the curve,” Dr. Peacock said. “It’s essential to get ahead of what might be around the corner because we don’t know how the virus is going to evolve.”
A version of this article first appeared on.


text:
Nobel Laureate Herbert A. Hauptman, Ph.D., has been recognized by the highest levels of academia, the international science community, and the media because his work in the fields of mathematics and science saves lives. The Buffalo News said that because of his lifelong dedication to molecular level research “Hauptman…Undoubtedly saved more lives…than anyone else in recent history.” Through his work at the Hauptman-Woodward Medical Research Institute, Dr. Hauptman continues to pave the way for pharmaceutical breakthroughs, advances in medical procedures, and the groundbreaking research done by his fellow crystallographers throughout the world.
Born in New York City in 1917, Dr. Hauptman received his bachelor’s degree from City College in 1937, his master’s degree from Columbia in 1939, and his doctoral degree from the University of Maryland in 1955.
About the work which led to Dr. Herbert A. Hauptman’s 1985 Nobel Prize in Chemistry
When a beam of x-rays strikes a crystal, the incident beam is split into many weaker beams having different directions and different intensities, thus giving rise to what’s called the diffraction pattern. The nature of the diffraction pattern, which is to say the directions and intensities of the scattered x-rays, is determined by the structure of the crystal, that is the arrangement of the atoms in the crystal.
If one knew the structure of the crystal, one could readily predict the nature of the diffraction pattern, that is the directions and intensities of the x-rays scattered by the crystal.
However, the problem facing the crystallographer is the converse: One observes the diffraction pattern – that is one measures the directions and intensities of the X-Rays scattered by the crystal. Can one then deduce the structure of the crystal, that is the atomic arrangement, giving rise to the observed diffraction pattern?
The 1985 Nobel Prize in Chemistry was given for the solution of this problem.
The ability to solve crystal structures rapidly and routinely had important consequences. Possibly the most important was the ability to relate crystal and molecular structures to biological activity. Thus it became possible to understand life processes at the “molecular” level, to understand better how living things “work,” and the cause of disease, and to devise better therapies and better drugs for the prevention and treatment of disease with a minimum of adverse side effects, in short to improve human health.
X-rays strike a crystal. The crystal contains a molecule, which is repeated throughout the whole crystal in all directions. The crystal deflects the x-rays in certain definite directions so that the radiation can be seen as spots of different intensity such as in a photographic film.


text:
How to beat candy crush level 33. candy crush saga is a difficult game, but level 33 really turns up the heat. you are provided with four separate game boards, each. How to beat level 33 on candy crush saga without boosters? a lot of friends has been clearly frustrated with level 33 on candy crush saga, without using boosters. Beware, candy crush is addicting! it is a simple game that becomes challenging and mind boggling with each level. it is tempting to spend extra dollars on upgrades to. Candy crush level 70 is one of the first extremely hard levels in candy crush saga. in level 70, you must clear 28 jelly squares as well as score at least 60,000. The video above is an example of how to finish candy crush level 76 without relying on luck. it is pure analysis of each and every move you have..
How beat candy crush level 70 - candy crush guides, Candy crush level 70 extremely hard levels candy crush saga. level 70, clear 28 jelly squares score 60,000.


text:
Alzheimer's disease seems to be growing not only in awareness but in the number of people having it and dying from it. Even without having full blown Alzheimer's, more and more are suffering from dementia and its different forms. What are some supplements and other things people can do to help avoid Alzheimer's disease and other brain problems like dementia? What can be done to help lessen the "plaques" we hear that build up in the brain?
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I agree - well said. Avocados are great and walnuts are often dismissed.
Eat better Stay healty Food heals
Just A thought: If the arteries are clogged with plaque, and diminishing blood flow to the brain, it would also be a contributing factor. Might wanna address that issue also.http://artist101.hubpages.com/hub/Heart-Health-Nat...
Some studies have shown an increased risk of developing AD with environmental factors such the intake of metals, particularly aluminium, or exposure to solvents. I beg to Differ
Some preliminary results of studies on high-dose inositol supp

domain: medical


This addon is made by Cpt.misha and merhabi , powered by Cold War Mod Team
Description fits :D
Yay it does :D
This is just pure OP.
I think the minigun need some explosive rounds :)
Explosive and flame rounds :D also flame grenades for grenade launcher and flamethrower ;)
Great work. Happy to see new vehicles being made. Any mini-missions being made yet? xP
It is wonderful cold war tank has appeared, appreciate your enthusiasm,please continue, very thanks !
лучше сделай самолет юнкерс 87 штуку образца 1941 года а этот танк не подходит к тому времени
There is a slight problem the penetration of the main gun, compare it with this Fas.org , penetrations at the bottom.
Other than that the model, armour and the ultimate rapid fire grenade launcher(infantry are screwed ;D) are epic as well as the 40mm penetrating minigun.
i was working on it many months ago, at that point i wasnt able or just way to lazy to make a more op gun xD
Pity, it takes away the most of the power of the tank.
It's because it uses the 128mm PaK 44.
Can u do the American M105 Heavy tank of the cold war
nope XD i am sorry, i dont even know which tank is that :D
@Curtis - If I'm not mistaken, there's no M105 only M103 Thetankchannel.com of which Jonvigo's mod Tanks of War, has the heavy tank M103 on it.
U can take jovingo's mod but that is for MoW not for MoW:AS , but he said he will make mod for AS too ;)
Maybe make a skin pack for the tank?
ok i will
Good thing that some those ******* Arma fanatics aren't giving you guys, Cpt. Misha and Merhabi, a hard time. Hope you upload more mod of the tanks on Cold War mod.
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You done great work Cpt.Misha and yes marry Chrystmas in the future and happy new year and I hope we will be in peace with each other.
one problem someone made a mini mision with this mod and the gun moves realy weird in the turret
You made cool 3D models and skins, i want you in my team, PM me.
Only registered members can share their thoughts. So come on! Join the community today (totally free - or sign in with your social account on the right) and join in the conversation.
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text:
An attempted burglary was reported in the 300 block of West Aster Lane from noon to about 2 p.m. April 30. Pry marks were found on a window but entry was not gained.
Jewelry valued at more than $10,000 was taken from the 11000 block of North Crestline Road before 8:20 p.m. April 30. There was sign of forced entry.
Two 15-year-old Milwaukee girls were arrested, one for operating a motor vehicle without the owner's consent, driving without a valid license, failure to stop, reckless driving and felony fleeing and the other for party to the crime of operating a motor vehicle without owner's consent and felony fleeing at Mequon and Cedarburg roads at 3:45 p.m. May 3. They were in a van stolen from Milwaukee and inside it were items reportedly stolen from Brown Deer. The driver admitted she had taken the van. The girls were turned over to Brown Deer police.
A 25-year-old Mequon man was arrested for drunken driving and driving left of center in the 6100 block of West County Line Road at 2:45 a.m. April 28. The man appeared "confused" and admitted having three beers and a shot. His blood alcohol content was 0.11.
A 31-year-old Milwaukee man was arrested for drunken driving and driving while suspended after another driver reported him weaving in traffic at Mequon and Port Washington roads at 5:15 a.m. April 28. The man, who spoke little English, said he was lost. His BAC was 0.17 and he was taken for a blood draw.
A 22-year-old Port Washington man was arrested for drunken driving, with a prior conviction, driving after revocation and left of center in the 14400 block of North Green Bay Road at 2:35 a.m. May 3. The man had a preliminary BAC of 0.108 and was taken for a blood draw.
A 15-year-old Mequon boy was turned over to juvenile authorities on allegations of possession of drug paraphernalia and damage to property in the 4200 block of Le Grande Boulevard after a relative came to the police department at 10 a.m. April 28 with a water bong homemade by the boy. The boy reportedly damaged a door knob at the home.
A 25-year-old Green Bay man was arrested for possession of drug paraphernalia, with three previous drug arrests, driving while suspended, failure to have insurance and not wearing a seat belt on Mequon Road at Lilac Lane at 8 p.m. April 29. The man, who was on probation, locked his car and when it was unlocked police found a syringe and other paraphernalia which are being tested for drug residue. An 18-year-old Grafton man, who arrived to pick up the suspect, was arrested on an outstanding warrant.
During the last six months, residents have turned in over 560 pounds of prescription and other medication for disposal at Concordia University and Mequon Police Department.
Several used pairs of brake rotors and used shocks, value unknown, were taken from a storage area during normal store hours at a business in the 100 block of South Main Street at 1:39 p.m. May 2. The business holds onto the items and sells them to a recycler.
A 59-year-old Thiensville man was arrested for disorderly conduct in the 100 block of North Orchard Street at 7:46 a.m. May 4. A parent of a student that attends a local school, pulled onto the approach of a driveway of the Thiensville man to drop off her daughter's backpack before her daughter boarded a school bus. The student has a medical condition that restricts the child from carrying the backpack. As the mother got out of the vehicle and took the backpack across the street, the 59-year-old Thiensville man came out of his residence and removed the keys from the ignition of the van. A 7-year-old was in the vehicle when the man opened the van door and removed the keys, the child is another daughter of the van's owner. Upon further investigation, the vehicle was within the village right of way, not of the homeowner's property.
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- Mequon-Thiensville Police Reports, Feb. 11, 2016
- Mequon-Thiensville Police Reports, Jan. 28, 2016
- Mequon-Thiensville Police Reports, Jan. 21, 2016
- Mequon-Thiensville Police Reports, Jan. 14, 2016
- Mequon-Thiensville Police Reports, Jan. 7, 2016
- Mequon-Thiensville Police Reports, Dec. 31, 2015
- Mequon-Thiensville Police Reports, Dec. 24, 2015
- Mequon-Thiensville Police Reports: Dec. 10, 2015
- Mequon-Thiensville Police Reports, Dec. 3, 2015
- Mequon-Thiensville Police Reports, Nov. 26, 2015
- Mequon-Thiensville Police Reports: Nov. 19, 2015
- Mequon-Thiensville Police Reports, Nov. 12, 2015
- Mequon-Thiensville Police Reports: Nov. 5, 2015
- Mequon-Thiensville Police Reports: Oct. 29, 2015
- Mequon-Thiensville Police Reports: Oct. 15, 2015
- Mequon-Thiensville Police Reports: Oct. 8, 2015
- Mequon-Thiensville Police Reports: Oct. 1, 2015
- Mequon-Thiensville Police Reports: Sept. 24, 2015
- Mequon-Thiensville Police Reports: Sept. 17, 2015
- Mequon-Thiensville Police Reports: Sept. 10, 2015

domain: law


text: The melancholy music that runs throughout this five-part British drama sets the tone for the story of one of England's most well-known literary families. As it opens, the surviving four children of the Rev. Patrick Bronte enjoy a close childhood in the sheltered environment of the parsonage at Haworth. In his youth, son Branwell (1817-48, played by Michael Kitchen) fails to live up to the family's high expectations, engaging in an unwise romantic liaison and drinking too much. The lives of Charlotte (1816-55), Anne (1820-49), and Emily (1818-48) provide insight into the limitations on women in this period. Sadly, all four siblings died before age 40, so we'll never know their true potential. Bonus material offers background on the Bronte home. VERDICT This slowly paced, somber series highlights the somewhat tragic lives of the Brontes.