text:
|1.||Catania, Anna: 2 articles (03/2012 - 01/2010)|
|2.||Gatti, Stefano: 2 articles (03/2012 - 01/2010)|
|3.||Carlin, Andrea: 2 articles (03/2012 - 01/2010)|
|4.||Leonardi, Patrizia: 2 articles (03/2012 - 01/2010)|
|5.||Sordi, Andrea: 2 articles (03/2012 - 01/2010)|
|6.||Lonati, Caterina: 2 articles (03/2012 - 01/2010)|
|7.||Vincenot, Amélie: 1 article (02/2015)|
|8.||Chezal, Jean-Michel: 1 article (02/2015)|
|9.||Miladi, Imen: 1 article (02/2015)|
|10.||Bouchon, Bernadette: 1 article (02/2015)|
01/01/2008 - "The in vivo affinity and specificity of the radioconjugate to MC1R were demonstrated by receptor-blocking studies with the potent NDP-MSH agonist (63.5% reduction in tumor uptake at 4 h p.i.)."
02/01/2009 - "This resulted in enhanced extravasation of NDP-MSH-PEG-HAuNS from tumor blood vessels and their dispersion into tumor matrix compared with nonspecific PEGylated HAuNS. "
02/01/2009 - "The biodistribution of NDP-MSH-PEG-HAuNS was assessed at 4 hours post i.v. injection in tumor-bearing nude mice. "
12/01/2002 - "Therefore, (111)In-DOTA-MSH(oct) displayed higher uptake ratios of tumor to nontarget tissue (e.g., tumor-to-bone ratio 4 h after injection was 4.9 for (111)In-DOTA-NDP-MSH and 53.9 for (111)In-DOTA-MSH(oct)). "
02/12/2015 - "Then, radiolabeled [ (125) I]/[ (18) F]TFIB was used to tag tumor-targeting peptides (i.e., PEG3[c(RGDyK)]2 and NDP-MSH targeting αvβ3 integrin and MC1R receptors, respectively) in mild conditions and with good radiochemical yields (47-83% d.c.) and purities (>99%). "
|3.||Melanoma (Melanoma, Malignant)
01/01/2013 - "Our new melanoma cell lines were BRAF mutated in hetero- and homozygosis, even with a wild type MC1R, and unresponsive to NDP-MSH treatment. "
02/01/2009 - "NDP-MSH-PEG-HAuNS have the potentials to mediate targeted photothermal ablation of melanoma."
06/01/1990 - "In melanoma specimens from 11 patients, 3 showed high levels of specific binding, 5 showed low levels, and in 3 patients specific binding of [125I]NDP-MSH was not detectable. "
02/01/2009 - "The intracellular uptake of the NDP-MSH-conjugated PEGylated HAuNS (NDP-MSH-PEG-HAuNS) and the distribution of beta-arrestin were examined in murine B16/F10 melanoma cells. "
05/01/1992 - "In both mouse and human melanoma tissues, concentration-response relationships for DAB389-MSH-mediated inhibition of 125I-NDP-MSH binding were parallel, and its maximal effects were comparable in magnitude, to those of NDP-MSH and alpha-MSH. "
|4.||Body Weight (Weight, Body)
09/01/2012 - "In the next study, a subthreshold dose of β-EP was injected together with Nle(4), d-Phe(7) (NDP)-MSH after a 16-h fast, and the negative effects of NDP-MSH on refeeding and body weight gain were partially reversed. "
04/22/2005 - "Acute and chronic intracerebroventricular administration of several different analogues of alpha-MSH, such as alpha-MSH, NDP-MSH, alpha-MSH-ND, [Gln(6)]alpha-MSH-ND, and [Lys(6)]alpha-MSH-ND, which were substituted in the position of His(6) with Gln and Lys, and cyclic16k-MSH to C57J/BL6 mice resulted in a significant inhibition of both time course food intake and body weight gain, compared to the saline-administered control. "
|6.||Melanocyte-Stimulating Hormones (MSH)
|7.||Adrenergic Receptors (Adrenergic Receptor)
|8.||Polyethylene Glycols (Polyethylene Glycol)
|10.||Immunoglobulin G (IgG)
|1.||Dilatation and Curettage (D&C)

domain: literature


text:
The United Kingdom is finally set to leave the European Union on Friday and Prime Minister Boris Johnson will deliver on his election promise to “Get Brexit Done”.
The Brexit process was an extremely divisive issue that split the country for more than three and a half years of voting to leave.
January 31 will be seen as a day of salvation for the leave campaign and February 1 will mark the beginning of a new phase of negotiations between London and Brussels to agree on the shape of their future relationship.
They have until the end of 2020 — a transition period during which Britain will remain an EU member in all but name — to hammer out an agreement on trade and other issues including security, energy, transport links, fishing rights and data flow.
The terms of the UK’s departure from the EU was backed by members of the European Parliament, MEPs ratified the Brexit Withdrawal Agreement by 621 votes to 49 following an emotional debate in Brussels.
After the vote, MEPs marked the UK’s exit by singing Auld Lang Syne.
The Parliament’s president, David Sassoli while signing the letter confirming the EU’s consent said the two sides must heed the words of the late Labour MP Jo Cox when approaching their future relationship and recognize “there is more that unites us than divides us.”
“You are leaving the EU but you will always be part of Europe…It is very hard to say goodbye. That is why, like my colleagues, I will say arrivederci.”
The Parliament’s Brexit spokesman, Guy Verhofstadt, said it was “sad to see a country leaving that has twice given its blood to liberate Europe”.
He added that British MEPs had brought “wit, charm, and intelligence” as well as “stubbornness”, and would be missed.
President of the European Commission Ursula von der Leyen said ratification of the withdrawal deal was “only a first step” towards a new partnership between the EU and the UK.
Nine African Nations In Debt To UN Lose Voting Rights
Nine African countries, who are owing membership dues to the United Nations, are about to lose their voting rights in the general assembly. Niger, Central African Republic, Somalia, Comoros, Libya, the Congo, Zimbabwe, South Sudan and Sao Tome and Principe are reported to be indebted to the United Nations.
U.N. Secretary-General, Antonio Guterres, says the African nations, and Iran, should lose their voting rights as required under the U.N. Charter after defaulting on payment of their dues to the united nations’ operating budget.
Guterres listed in a letter to the United Nations General Assembly president, Volkan Bozkir, on monday, the minimum each country must pay for their voting rights to be restored.
The U.N. Charter gives the 193-member general assembly the authority to decide “that the failure to pay is due to conditions beyond the control of the member,” and in that case a country can continue to vote. That has not been invoked in these cases.
America Prepares For Presidential Inauguration Amid Fears Of Insider Attacks
The United States is preparing for an unprecedented presidential inauguration on Wednesday. Prompted by the Capitol insurrection twelve days ago, more than twenty-five thousand national guards troops have been brought into Washington, DC to provide security for the event.
US defense officials have also expressed fear of an insider attack or other threats from security troops assigned to provide protection during the inauguration.
Small protests also took place at heavily fortified state houses around the country. There were widespread fears of violence against state capitols across the country like the siege on the U.S. Capitol. There has been no report of violence.
Some have described the scenes of national guard troops taking over the streets around the US Capitol, as looking like the war zones of Afghanistan or the Middle East.
Amid this background, Joe Biden will deliver his inaugural address of national unity when he is sworn in on Wednesday. He plans to immediately jump into action after swearing-in. He plans immediate moves to combat the coronavirus pandemic that has claimed more than four hundred thousand American lives. He also promised to issue many executive orders to undo some of Donald Trump’s most controversial policies.
He says his first order of business would be an executive order signing America back into the Paris Climate Accord. He will also revoke Trump’s immigration ban on some majority-Muslim countries.
23 Norwegians Dead After Taking COVID-19 Vaccine
The New York Post has quoted Norwegian health officials as saying twenty-three persons have died within days of receiving the first dose of the Pfizer COVID-19 vaccine. Thirteen of the deaths are said to be related to side effects of the shots. All thirteen were nursing home patients who were at least eighty years old.
The newspaper quoted the chief physician at the Norwegian medicines agency, Sigurd Hortemo, as saying in a statement on Friday, common reactions to the vaccine, including fever and nausea, may have contributed to a fatal outcome in some frail patients.
This has forced officials to adjust their guidance on who should receive the vaccine, but they are not expressing serious concern.
The country has inoculated more than thirty-thousand citizens with the first shot of the Pfizer or Moderna coronavirus vaccine since last month.
Norwegian medicines agency medical director, Steinar Madsen, says the agency is not alarmed. He says the vaccines have very little risk.

domain: politics


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By David Knopf/Richmond News
Richmond Public Schools received seven applications from individuals interested in completing the final year of a school board seat vacated last month.
At a special meeting Tuesday, the board reviewed applications and decided to interview the candidates in open session at 7 p.m. May 7. The individual chosen to fill the vacancy would be sworn in May 14, the board’s next scheduled meeting.
The applicants, all Richmond residents, are James R. Schmidt, April Maulsby, Valerie Miller, Jason Berning, Tof McWilliams, Stephanie Landwehr and Donna Baker.
Schmidt and Miller are former school board members. Maulsby and McWilliams were unsuccessful candidates for a seat in the April 2 election. Berning is a former city councilman. Landwehr is executive vice president of Community Bank of Missouri.


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In short, Johnny Ive, a former Apple Chief Design Officer and Consultant who is most responsible for the visual appeal of Apple products, has made computers and phones more than just a vector of features, but computers and phones. Helped to turn it into an object of desire.Rather an identity badge — and his former employer I allegedly agreed To break their last bond.
What does this mean for “Mixed Reality” headsets? There are rumors that the entrance to the Metaverse may be released by Apple in the second quarter of next year. In other words, what does that mean for us, where the willingness to engage in substitute reality can be transformed by such devices?
After all, how the company designs equipment that makes you want to put a contradiction on your face so that you can enter another world while your body is in this world. If you can solve the problem, it’s Apple.
If a company could overcome the predecessors of Google Glass and Oculus to create a wearable computer that didn’t look like a computer, it would be the company that did it with laptops, music, earphones, and most of all, smartphones. .. If brands can solve the challenge of making their entry into the Metaverse fashionable, that’s another issue. After all, making Metaverse fashion is just as important to making Metaverse meaningful (and accessible). Become Apple.
Except that maybe not anymore.
Without Ive, is Apple’s era as a bridge between hardware and software really nearing its end? Are we at a turning point between the old Apple and the new Apple, that is, between one Apple and possibly another? For example, Phoebe’s Céline and Hedi’s Celine.
What is the Metaverse and why is it important?
origin. The word “Metaverse” is A fully realized digital world It exists beyond what we live in. Neil Stephenson coined it in the 1992 novel Snow Crash, and Ernest Cline explored the concept further in the novel Ready Player One.
In any case, it heralds another kind of paradigm shift.
For most tech companies, the resignation of a designer won’t get the attention of the public, but part of Apple’s greatness lies in the way it borrows from the fashion world to drive consumption.
Steve Jobs knew that he could adopt a fashion strategy and apply it to previously boring and boring appliances. As a result, fashion has become tactile and visually appealing, thin, smooth and chic, helping the company transcend the industry. It was Jobs who embraced the value of the new model each season. A person who understands how planned obsolescence, which is an essential premise of fashion, can be applied to functions. And how to incorporate a value system into the aerodynamic line of a device to make it more than the mechanical sum of its parts.
He joined the company in 1992, defining the look of Apple for decades and providing accessories (iPad covers, iPhone covers).
The rest is not important Jobs’ death In 2011, Ive emerged from the shadows with CEO Tim Cook and became the face of the company. If Cook was an unpretentious technocrat, Ive would have been a visionary person. He is a friend of Marc Newson (Lockheed Lounge designer) and designer Azzedine Alaía, who advocated the fusion of technology and fashion that happened before and after the debut of the Apple Watch. 2014.
The first hiring turmoil broke out — former YSL CEO Paul Deneve became vice president of a special project in 2013. The following year, TAG Heuer’s former Tarick Prunier was the senior director of the special project. In 2014, Burberry’s former Chief Executive Officer, Angela Ahrendts, served as Senior Vice President of the Retail Division, and has since expanded.
There was an unveiling ceremony just before New York Fashion Week. Dinner party in Paris Rebir at the concept store Collet with Mr. Alaia. The protagonist of the cover of China Vogue. And finally, in 2016, Ive appeared as the host of the Met Gala with Anna Wintour.
But in the end (and finally Collaboration with Hermes), The clock is now Not very fashion Disruptor as a gadget for health and wellness. Mr. Denive left in 2016. Mr. Aalentz and Mr. Prunio became consultants with Mr. Ive in 2019.
Since then, Apple hasn’t had a Chief Design Officer. Apple executivesThere is no single presiding visual point of view. Instead, Ive’s duties were split between Evans Hankey, Vice President of Industrial Design, and Alan Dye, Vice President of User Interface Design.
Still, Hanky and Dai have been working with Ive for years on products such as the MacBook Air and watches, and at least nominally Ive seems to have maintained a bond as a keeper of fire and aesthetics. was. ..
until now. That’s why future headsets and their appearance are so important. Perhaps, given the potential timing, it will be the last product to have Mr. Ive’s fingerprint on its design. But maybe it’s a sign of something more.
Apple and Ive declined to comment on their relationship to this article. But if Apple proves that this is the beginning of a new era, not the end of its commitment to style as a signifiant, but the beginning of a watered-down version of the previous one, it could be almost a cliché. A case with tinged edges and a smooth silver — this is the first real test. This is also an opportunity to redesign our thinking about the product, not just the product, or Apple itself. Ive reportedly nodded his headset for the last few years of the deal, but it may be desirable not to repeat it enough to redefine it.
Indeed, the fact that the watch didn’t prove a game changer or industry mover is that Mr. Hanky (or someone else who knows) has the opportunity to claim himself by creating something new. Means. brand.
Think of it this way: Gucci and Celine or Max Mara? Do you flip everything we think we know and recreate it for a new reality, or do you make sure it goes through the movement over and over again, if not exciting? All the signs show the Max Mara model, but if fashion can tell us, the brand will withstand the changes of the designer as long as the company really cares and empowers the designer. I can.
Once upon a time, Apple learned some valuable lessons from fashion. See if it can do it again.

domain: design


text:
Each customized piece of furniture is the outcome of a long process that entails several drafts and research. Each piece contains our tradition, the experience and the love for the wood of our family.
Today, after more than fifty years, the company do its best to preserve the family tradition, which makes its unique. The philosophy of Vangelista Mobili 1960 combines the best artisan tradition with the newer techniques. Our furniture joins the new and the antique, something that was born long time ago with something innovative. The result is a unique furniture, customised and handmade, artisan and perfect because it was made by the hands of wise artisans. A long tradition of cabinet making that distinguishes our brand, a perfect model of luxury Made In Italy.
Excellence, beauty, harmony, knowledge: these are the words that represent our brand, words that became real in our artisan furniture. Vangelista Mobili 1960 can recreate lines and volumes of different epochs, designing and making precious, luxury furniture.
To choose Vangelista Mobili 1960 means to have the guarantee of having an artisan and handmade furniture that lasts forever, because they are realized by our wise artisans.

domain: artistic


DVF, Coco Rocha release new books
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You won't believe how much North's earrings cost
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The trend report: Ladylike dressing
Will Léa Seydoux be the next Bond Girl?
Who wore what this weekend: Bridal inspired
Look of the week: Selena Gomez's sleek bun
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Get the look: Kate Bosworth's slouchy boyfriend coat
The latest in fashion, beauty, and hair – delivered straight to your inbox.
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People tend to check in during these times:
Three great stages, one great hall.
Construction began in 1890 and it was named after Andrew Carnegie, who paid for its construction. It opened May 5 1891 with a concert conducted by Walter Damrosch & composer Peter Ilyich Tchaikovsky
The best of the best in classical music can be seen performing on the stage.
One of the most prestigious venues in the world, the 120+ year old Carnegie Hall combines spectacular architecture with the world's most distinguished artists and composers.
The Doors performed Carnegie Hall back in the winter of 1971!
Judy Garland's album "Judy at Carnegie Hall" was recorded here on April 23, 1961 & won Album of the Year at the 4th GRAMMY Awards in 1962
Millions dream of stepping onto the stage that’s hosted Dr. Martin Luther King, Jr., George Gershwin, Bob Dylan, and many other greats. - Green Guide Editor
See an orchestra play. Become a member to attend nice reception afterward...
Visiting this classical musical venue is always a royal evening out thanks to its historic aura. Virtually every great musician has performed here.
Don't forget to check in while here so your crew remembers how cultured and sophisticated you are!
Get to the show early to avoid having to wait outside for an opening act to finish. Make the most of the opportunity to dress up and swan around the lobby with a glass of champagne.
Enjoy a classical concert at Carnegie Hall.
Rufus Wainwright comes to Carnegie Hall this winter. Get your tickets now.
One of the best concert halls in the world!
In 1903, President Teddy Roosevelt joined with Methodist bishops to honor the 200th anniversary of John Wesley's birth (from "Methodism and Politics in the Twentieth Century" by Mark Tooley).
It’s not surprising that this historic venue has the best acoustics in the city! Take advantage of the partial view ticket discounts – 50% off! It’s worth it.
Grab a few free cough drops upon entry.
In Gayle Forman's novel WHERE SHE WENT, Carnegie Hall is where the main characters, Adam & Mia, see each other for the first time in three years.
Oh you fancy, huh? Then take advantage of the $10 student rush tickets on 57th and Seventh for Carnegie Hall.
The wine is a rip-off--get a mixed drink instead!
For some pop artist concerts, they set out bins of Ricola throat drops for guests to grab from on their way out. So don't be afraid to bring your inner tweeny bopper and SHOUT your hearts OUT!
The legend.Not to be missed. Show up day of early to try and get last minute 'day of' discounted tickets. Brilliant acoustics. All the greats have played here. The Beatles, Judy, The Doors, etc..
Share your reviews on over 30 city/state Theatre Chat groups on Facebook.
Carnegie Hall opened in 1891. 46,000 events have taken place since its opening. The youngest performer to have performed at Carnegie Hall was four year old Lolita Val de Cabrera in 1900.
Legendary concert venue where they have performed Louis Armstrong, Benny Goodman, and others unforgettable legends!
One of the world's greatest concert halls, choose from three spaces, holding between 268 and 2,800 people.
Leave a comment about this venue on the Reuters Business Traveller page
2nd row balcony, still a great view
Go to see Trey Anastasio play with the New York Philharmonic
Good gift shop, excellent performances, amazing acoustics, ambient atmosphere, and an ornate hall perfect for any performance no matter the occasion. What's not to love?
Beautiful acoustics and decor
Download Full HD Movie Free Free Movies, Full Movies, Full Movie Download, Full HD Movie Download, Download Movie, Download Full HD Movie Free,d http://downloadfullhdmovie2364.blogspot.com/
Fantastic venue. You can really see the age in this historical theatre.
The least comfortable seat I've been in for years. Serious kneebusters.
If you're seeing a show and your tickets are at will call, you can save a lot of time by picking them up anytime before the show (even that day). The will call line the day of a show is a mad house.
Keith Jarrett done good tonight.
10$ student tickets!
Phenomenal venue. No bad seats.
space between ones share and the one in front is horrible. If you're late you have to get the whole row to stand. Beautiful auditorium though
Great place for classical music...trivial but true
The greatest most beautiful and deep music in the world played by the world's greatest musicians! 😃🎵🎵🎵
no need to get here early, since they have seats.
Зал похож на зал им. Чайковского в Москве. Обще принято сидеть в верхней одежде
Um Clássico! A estação de metrô lhe deixa na porta!
공연이 끝나고 브로드웨이로 걸어갈때 그 헛헛한 마음과 그걸 위로해 주는 네온사인. 카네기만 줄수 있는 또다른 감동.


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HomeMade Bath Recipes ~ Who doesn't like bath fizzy bombs? I know my kids go crazy over these things and you can easily make these DIY bath fizzy bombs yourself!
CoOl DIY - Coconut Loofah Soap by Essentially Eclectic. Easy soap-making tutorial using coconut flakes, coconut fragrance oil, and a loofah sponge!
If you like bath bombs you’ll love these eucalyptus shower steamers! These solid disks melt, fizzle, and bubble apart in your steamy shower and release aromatherapy scents. If your health care provider.

domain: hobby


New Artel last year benefited from government’s Rwf1.5b universal access fund to provide telecommunication services in rural areas that MTN Rwanda and Rwandatel do not cover
New Artel, a government Information Communication Technology (ICT) company over the weekend unveiled its new brand.
The Chief Executive Officer (CEO) of New Artel, Francis Karemera, said that the new look comes with promises that it will contribute to the country’s Vision 2020 for economic development through ICT. He said that under the new face, it now takes about 24 hours to get connected after applying for bandwidth.
“This is because of the establishment of field offices in all provinces countrywide and the use of both radio and satellite transmissions,” Karemera explained.
One of the latest services under the new look is the Digital Video Broadcasting-Terrestrial (DVB-T) connection, which is the modern standard for the broadcast transmission of digital terrestrial television.
This system transmits compressed digital audio, video and other data in a Moving Picture Experts Group (MPEG) transport stream, using COFDM modulation.
New Artel also established Virtue Private Network (VPN) that uses a public telecommunication infrastructure, with a footprint covering three-quarters of Africa.
This allows corporate entities to keep in touch with remote branches and strategic posts. Well as connectivity from New Artel to the database servers are provided via terrestrial Fiber Optic network or a radio link.
The government agency that also works with the utility authority (Rura) and development board (RDB), operates iDirect 5IF which is a powerful Internet Protocol based hub that is operated on Intelsat, the leading provider of fixed satellite services (FSS) worldwide, a full coverage to the majority of Africa.
Against this background, the company guarantees 99.8 percent link availability, even with the small terminals (VSAT) used by New Artel.
This believed to enable the company to provide the required bandwidth at any moment to all regions extending from the Sahara desert to South Africa.
All these applications are expected to increase the Internet bandwidth that can bridge the digital divide across the country.
As the largest supplier of internet access in Rwanda, New Artel targets to deliver internet trunk to 120Mbps by end of this month and lower the cost of connection to below US$1800Mbps/month by mid this year.
Currently, the company offers subsidised bandwidth at Rwf275,000/Mbps/month.
Karemera added that the company is committed to drive down the cost of communication in the country by evaluating new technologies and optimising the existing one.
With operating sites in rural areas equipped with adequate bandwidth, most government institutions in rural areas are connected. Some of these include, health centres and schools among others.
However management explained that capacity increased is also backed by the lay out of the national backbone optic cable, targeting to improve rural connectivity and turn Rwanda into a knowledge-based economy.


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Gokada suspends services temporarily to redress issues.
This is contained in a statement issued by Fahim Saleh, Gokada CEO, on his Medium page.
Saleh revealed the break would last for 12 days beginning from Wednesday, August 14 to Sunday, August 25.
We are dedicated to rewriting the ills the motorcycle taxis represent. This has nudged us to take this compulsory break of 12 days which begins Today, Wednesday, August 14th 2019 to the 25th August 2019.
We will be back Monday, August 26th, with retrained drivers who are safety conscious, clean, courteous and are better with driving and navigation.
Other features to expect include better traffic law-abiding pilots, brand new bikes amongst other things.
“We are deliberate in our commitment to revamping the narrative of transportation.”
He further revealed that the company has failed in some ways despite succeeding in others.
“Increased competition, regulatory hurdles, and operational issues have forced us to make this decision. We thank all our loyal users and are truly sorry for this inconvenience,” he wrote.
Gokada was started to change the perception of what the bike taxi could be in terms of safety, convenience, and transparency.
“In many ways, we’ve succeeded but we have also failed. We can only win by doing right to our customers and our pilots.”
The company, which started operations in February 2018, said it was already completing 5,000 rides a day during its one-year anniversary.
It recently raised $5.3 million in a Series A fundraiser.
Despite being a new enterprise, the motorcycle taxi-hailing space has witnessed rapid expansion with the entry of O’Ride and Maxng.

domain: news


text:
LONDON — In a dusty, overheated rehearsal room near London Bridge, things were getting ghoulish. On a mocked-up stage set, a soprano wearing a mask with black buttons over her eyeholes was slamming a fake hand into a door, trying to make it look as if it had been severed. Around a table, two “magic consultants” were huddled around a miniature toy theater, debating what sort of fake mice would freak audiences out the most. Eerie, discordant chords drifted from another room: A trio was practicing. “You’re doomed,” they seemed to be singing.
It was the fourth week of rehearsals for the Royal Opera’s new adaptation of Neil Gaiman’s Gothic children’s novella “Coraline”, and no bumps in the night were being left to chance. The seven singers had memorized Mark-Anthony Turnage’s angular, complex score and had worked out where to stand and walk; today was all about making sure that the supernatural transformations required by Rory Mullarkey’s libretto happened where they were meant to. The piece presented an unusual number of challenges, sighed Aletta Collins, the director: Never before had she been required to work out how to throw someone through a mirror onstage, as happens at the climax of the action, let alone how one might recruit a mouse orchestra, which pops up in Act One.
“We’re doing our level best,” she said.
In the 16 years since it was published, “Coraline,” a tale of a plucky girl who falls into a parallel universe and battles forces from the dark side, has developed a passionate fan base, selling more than a million copies. In 2009 there came a stop-motion movie, and there have been video game and comic book adaptations, too — even an Off Broadway musical. Propelled by this, and by the astonishing success of other stories, such as the “Sandman” series and “American Gods,” Mr. Gaiman has become something of a cult figure, not just among the Comic-Con crowd, but in mainstream literary circles, too.
Even so, the idea of making a fantasy novel into an avant-garde opera still seems like a leap — and not only because of the mice. But then Mr. Turnage has always had eclectic taste: His last opera, which had its debut seven years ago, focused on the wayward life and tranquilizer-fueled death of Anna Nicole Smith, and his orchestral and instrumental works have gleefully referenced Miles Davis, the paintings of Francis Bacon and Beyoncé’s “Single Ladies.”
“If someone says you can’t do this, or shouldn’t do this, then I think it’s a very good reason to do it,” Mr. Turnage said in an interview. “It has to provoke me, otherwise I get bored.”
Though Mr. Gaiman hasn’t been directly involved in this new version — earlier this month he finished shooting a screen adaptation of his novel “Good Omens,” written with Terry Pratchett — Mr. Turnage and Mr. Mullarkey have had plenty to play with. The novel begins when little Coraline Jones discovers that a bricked-up door in the apartment she’s just moved into is a portal to a nightmarish “other world.” Trapped behind the door, she finds a figure with black buttons for eyes who coos that she’s Coraline’s “other mother” and promises her anything she desires, if only she agrees to stay “for ever and always.” Coraline’s journey home to her real parents is not only a coming-of-age story; it also becomes a mythic quest.
A powerful, self-determined heroine, Coraline is more than a match for operatic heroines like Leonore in Beethoven’s “Fidelio” or Rosina from Rossini’s “The Barber of Seville.” The role is shared in the new production by the sopranos Mary Bevan and Robyn Allegra Parton.
“She’s such a strong female character,” Mr. Turnage said. “She’s powerful; she’s going to solve these things. I’ve got a seven-year-old daughter. S he’s too young to read the book, but she saw the film, and she was very taken with Coraline.”
Although the opera, like the novel, is aimed at young audiences — Mr. Turnage has dedicated it to his daughter and his youngest son — it goes to some genuinely disturbing places. The sense that evil lurks around every corner is palpable; there are heavy hints, too, of abuse in the plotline of parent-like figures who bribe a child to love them. While critics have often compared the book to Lewis Carroll, Mr. Gaiman’s universe is arguably closer to David Lynch or Stephen King in its atmosphere of suspenseful, what-lies-beneath horror.
“I wanted to write about how people who have your best interests at heart may not always pay you the kind of attention that you’d like,” Mr. Gaiman said in a statement. “And people who pay a lot of attention to you may not always have your best interests at heart.”
Ms. Collins agreed that, despite its fairy-tale qualities, this narrative is not for the fainthearted. “The story is: You can have anything you want in the whole wide world, as long as you let me sew buttons into your eyes,” she said.
Mr. Turnage clearly relishes the material’s otherworldly side; the score, written for 15 musicians, is astringent and occasionally violent, bringing to mind early chamber pieces such as “On All Fours” (1983) and “Blood on the Floor” (1996). But “Coraline” does allow audiences some moments of fun. The composer said he enjoyed coming up with Broadway-ish music for the character of Mr. Bobo, an eccentric old man who dwells in the apartment above Coraline and conducts the mouse orchestra. Two retired actresses who live in the apartment beneath, Miss Spink and Miss Forcible, are portrayed as divas of a certain age who issue Cassandra-like pronouncements about fate in high-voltage coloratura.
“The fantasy element is so heightened,” Mr. Turnage said. “Completely operatic.”
The Royal Opera has staged eight new operas for young people and families in the last five years, among them Julian Philips’s “How the Whale Became” (2013), based on children’s stories by Ted Hughes, and Adriano Adewale’s “Hatch” (2017), billed as a “sensory experience for children aged 2 to 5.” The profusion indicates how seriously the company is trying to demolish the perceived barriers that surround the art form, and to attract new and more diverse audiences.
The company is under continual pressure to justify its annual governmental subsidy of around $33 million annually — the highest of any arts institution in Britain — and has invested in co-productions with theater and dance companies around the country. It also runs school workshops and outreach projects in towns outside London, including in some of the region’s most deprived areas.
Mr. Turnage, who grew up in Essex, not far from London, and was the first member of his family to get a college education, said he hoped audiences for “Coraline” would come from all walks of life. The opera world sometimes wasn’t as outward-facing as it should be, he suggested.
“A lot of opera directors are making opera for other opera directors, and quite a few opera composers are writing for their peer group,” he said.
Although “Coraline” has been in development for over four years, both he and Ms. Collins said that the theme of a young woman standing up for herself against the odds had acquired particular topicality in the context of the #MeToo and #TimesUp movements. The classical world has experienced plentiful rumors about sexual harassment, along with some high-profile firings — notably of the conductors Charles Dutoit and James Levine, who was pushed out of the Met earlier this month.
Mr. Turnage said that, while some things had improved over his years in the business, “I’m acutely aware of women working in the opera world and the way that they’re marginalized, and how tough it is. Everybody knows this.”
He added he was proud that, as well as having created a strong female lead, the production also has a largely female creative team, led by Ms. Collins and the conductor Sian Edwards. “The world is changing,” Mr. Turnage said.
He added that he hoped “Coraline” offered a path forward, in its way. He was inspired by a quotation from G.K. Chesterton that Mr. Gaiman uses as the epigraph of the book: “Fairy tales are more than true: Not because they tell us that dragons exist, but because they tell us that dragons can be beaten.”


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November 21, 2014, AOPA ePilot: Flight Training Edition
November 21, 2014 ePilot Training Tip: Fleshing out FICONs
Training Tip: 'Pilots are encouraged'
The FAA encourages pilots to do a number of things in order to increase safety, but does not require them. Check out these three actions that are recommended.
Flight made simple
Among the very first lessons a pilot learns is that a control yoke is not a steering wheel. Research underway in Europe could change that.
November 21, 2014, issue of 'AOPA ePilot' weekly newsletter
November 21, 2014 Air Safety Alert issued for holiday travel
IFR Fix: Why 'No SID'?
Your CFII usually follows up route-planning drilling with a review of appropriate regulations, and today's selection is 14 CFR 91.185, "IFR Operations: Two-way radio communications failure."
Report: China To Start Electric Airplane Production
Two copies of the Rui Xiang RX1E two-seat electric-powered airplane flew at the China Airshow, held last week in Zhuhai, and this week, it was reported that construction has begun on a manufacturing plant in Shenyang. Certification of the aircraft is expected later this year, and production is expected to begin in the first half of 2015, according to China Daily. The plant will be capable of producing up to 100 airplanes per year.
Garmin 7-Inch Display Now Shipping
Garmin now has a 7-inch G3X Touch display option available for experimental amateur-built and light sport aircraft, the company said this week. The high-resolution touchscreen display provides an option for owners of aircraft with smaller panels who may be looking for upgrades. The new screen also can be paired with a 10.6-inch display to serve as a backup or to provide a second screen with traffic, moving maps, charts or engine data.
GA Advocates Seek FAA Reform
The FAA should support the general aviation community in three key areas -- third-class medical reform, aircraft certification, and the ADS-B Out mandate -- AOPA President Mark Baker told a congressional committee on Tuesday. "We need the FAA to embrace a system that can keep up with rapidly changing technology; that is comfortable with timely, economical, and incremental safety improvements; and that will actually work to reduce risk today for hundreds of thousands of GA pilots," Baker said.
The Weekender: History, Gumbo, Gliding
With holidays and winter looming, activities in the northern half of the country are more scarce than usual this week, but SocialFlight still can help adventure-seeking pilots find plenty of places to go.
Airbus Patents "Flying Doughnut" Design
Airbus has filed a patent for a futuristic "flying doughnut" design for a passenger aircraft, the Daily Mail reported this week. The patent drawings show a circular cabin with seats arranged in a "doughnut" pattern, and a delta wing plan. The design aims to overcome some of the problems associated with pressurizing the traditional "flying tube" fuselage.


The Sport + range of spares provides everything you need to fine tune a Scalextric car to get the maximum performance from it on the track.
These Sport +, turned, aluminium hubs are hard wearing, ultra-light and perfectly round. Fitted with grub screws, the hubs can be located on to the axle with precision to ensure true running - an Allen key is included. The benefits of smooth running include better lap times and higher top speeds.
These hubs are designed for 3mm axles, and are not suitable for standard Scalextric axles.
The hubs come complete with high grip, silicon rubber compound tyres. Use these to improve lap times by reducing wheel spin and improving cornering speeds.
Wheels ø17.5 x 8mm (2x)
Tyres ø20.5 x 8mm fitted (2x)
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We continue to process and dispatch online orders for UK and International delivery.
Orders are dispatched 5 days a week (Monday to Friday).
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At Pendle Slot Racing we take great care and pride in making sure that each parcel is securely packed.


SpaceVac Is Featured In The New Issue Of Dust Safety Journal… Again!
That’s right, we have been featured in the latest issue of the Dust Safety Journal again!
Our DIV.2 certified cleaning system range has been featured in Dust Safety Journal’s most recent issue. Showcasing the ability to provide cleaning teams and BSC’s with the safest, fastest and most efficient to remove combustible dust and waste.
If you’d like to check out the latest issue of the Dust Safety Journal, click here.


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Providing safe and discreet healthcare online, the Lloyds Pharmacy Online Doctor service (LPOD) was the first of its kind in the UK. Launched in 2002, 1.3 million patients had registered with the service by May 2017 and it is now viewed as a reliable alternative to seeing a GP.
Apart from the obvious advantages of saving time and generally making life easier, the service is particularly helpful for people that want to find out more about sensitive issues such as sexual health.
However, whilst being widely used, research showed that users were still unaware that sexual health tests could be delivered to their door.
Delayed testing can lead to STIs, that would otherwise be easily treated, going undetected and potentially causing serious damage.
With a rise of Sexually Transmitted Infections (STIs) in the UK, LPOD wanted to raise awareness of remote healthcare as an effective solution for people who were either too embarrassed to go to their GP or who chose to ignore the problem until it was too late.
LPOD recognised that they needed a campaign that would not only reach the masses but would also be engaging enough to inspire behaviour change: ie, educate the public about the risks of STIs and encourage them to get tested.
Following extensive analysis of the market and researching existing content in the area of sexual health, we realised that to get people to take action, our communications had to have an element of:
To raise interest
To enhance social sharing
Statistics had to mean something to the reader
National statistics had to resonate with the audience
To drive people to take action
The first step was to design a customer friendly web platform for users to access the LPOD services.We initially produced a series of wireframes that concentrated specifically on the home and services page journeys.
This then enabled us to create mobile first, modular prototypes that actually shifted around the site based on how the user interacted with the content. Enhancing the user journey, it meant that users could find content that they were looking for much more quickly.
Identifying key demographics (Adults Over 50 and Young Professionals), we devised the "Sex Degrees of Separation" campaign. Using an algorithm to calculate potential exposure to STIs based on the number of sexual partners, the campaign aimed to encourage regular sexual health testing.
‘Sex Degrees of Separation’ was launched at the start of Sexual Health Week. We aimed to make the campaign highly shareable by specifically targeting students during Fresher’s Week and the Calculator was featured by sites such as LAD Bible and Cosmopolitan.
1.3 million people engaged with the brand – linking LPOD with Sexual Health
1.6 million completions of the calculator
20,000 Social Shares
1268 people went on to complete the STI assessment
97% increase in organic traffic
396 followed links
Successfully news-jacked Sexual Health Week ranking top for all related terms in Google News.
Successful with links from 12 of the most authoritative UK media sites including Mail Online and FHM.
Over 1.1 million people had used the calculator and engaged with the content.
Organic traffic for sexual health products increased by 97%


text: The Bulldogs could not bounce back from a slow start, dropping all three doubles points against Appalatchian Athletic Conference opponent SCAD Atlanta. SCAD clinched the match by picking up victories at 1 and 3 singles. The Bulldogs drops to 9-5 on the season, while the SCAD Atlanta Bees improve to 7-4 on the season. The Bulldogs finish up the regular season with a home match against Maryville College on Tuesday April 8th starting at 3:00 pm. Seniors: David Escobosa, and Bret Wade will be recognized in a ceremony before the match.


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For Knee Injections in our clinics, we use a combination of a specific knee injection called Supartz, as well as other knee pain treatment like massage therapy and physiotherapy in order to help our patients with knee pain relief.
What type of treatment is used for Knee Injections?
Supartz is a knee injection solution of highly purified sodium hyaluronate. Supartz is one of the hyaluronates used in viscosupplementation.
What does the Supartz Knee Injection do?
Supartz is injected directly into the knee joint to restore the cushioning and lubricating properties of normal joint fluid.
Supartz knee injections are approved for the treatment of osteoarthritis of the knee in those who have failed to respond to simple painkillers, exercise or even surgery.

domain: medical


- Published: 26 September 2017 26 September 2017
Ameren Missouri, a subsidiary of Ameren Corporation, plans to add at least 700MW of wind generation by 2020, representing an investment of approximately US$ 1 billion. The company also plans to add 100MW of solar generation over the next 10 years, with 50MW expected to come online by 2025.
The new wind generation is expected to be located in Missouri and neighboring states using American-made turbines. The source, location and cost of the new wind generation is still under negotiation with several developers. The addition of 100MW of solar generation over the next 10 years is expected to be developed in multiple phases.


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Minimalism is expressed through a project consisting of a very slim door featuring a painted aluminium structure to which a panel is applied, available in a great variety of finishes and materials ranging from glass to wood veneers and including Gres, allowing any style to be interpreted to perfection. Rough textures, slim panels and metal edges paired with handle-less channels design a kitchen featuring clean-cut, well-organised lines that becomes the hub of a setting readapted to accommodate an open space plan.
Base, wall and tall units as well as peninsula tables are in grafite Eucalyptus paired with drawers and worktops in Focos Roccia Gres. Eucalyptus peninsula tabletop.
The shelving unit with its open metal structure fits into the peninsula base units and becomes a partition that divides the kitchen from the living room. The uprights are in iron painted with a black finish while the shelves are in Eucalyptus wood veneer.
A practical space below the worktop is dedicated to H12 Gres drawers that create a single block with the top, giving the kitchen an elegant, linear appeal.


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Buying a fixer-upper can be an exciting and affordable way to get the home of your dreams, but renovating it can be daunting, especially if you're working with a limited budget. However, with some creativity and careful planning, you can turn your fixer-upper into the home of your dreams without breaking the bank. In this post, we'll share some tips for renovating a fixer-upper on a budget.
1. Make a Plan
Before you start any renovation work, it's essential to have a plan. Start by creating a list of all the renovations you want to make and prioritize them based on your budget and timeline. It would help if you also considered hiring an architect or contractor to help you create a plan that maximizes your budget and meets your needs.
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text: Single-step self-etch adhesive systems are the system that combine self etching primer and bonding agent into one step application. This system was developed as the effort to simplified in application prosedures and give a good bond strength of resin composites to dentin surface. The purpose of this study was to examine the bond strength of resin composites with two singlestep self-etch adhesives system (Xeno III and Clearfil Tri-S Bond) to bovine dentin at temperature of adhesive 3ºC, 22ºC and 30ºC. Adhesive was applied to dentin surface (bovine insisivus mandibular dentin) follow by resin composites bonded according to the manufacturer’s instructions. Tensile bond strength of 60 specimens were tested UTM (universal testing machine) after 24 hours storage in aquadest at 37 ºC. The results were analyzed using ANOVA test followed by Tukey’s test (p< 0,05). The bond strength of Xeno III was significantly diffrent from that of Clearfil tri-S Bond, 0,66±0,271, 2,70±1,528, 0,23±0,104 versus 2,07±0,272, 4,77±0,689, 4,39±1,205 MPa at temperature of materials 3ºC, 22ºC and 30ºC respectively. The bond strength of two single- step adhesives system (Xeno III and Clearfil Tri-S Bond) were highest at temperature 22ºC than other temperatures of materials.


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Saudi Arabia plans to implement insurance on domestic labor contracts within 2 months
The Saudi Central Bank “SAMA,” in collaboration with the Ministry of Human Resources and Social Development, plans to begin implementing the insurance decision on contracts for the recruitment of domestic employees in March.
The Ministry is finalizing procedures for domestic labor contract insurance, including integrating insurance companies to the “Musaned” platform for labor recruiting, and will issue a decision soon.
The domestic labor contract insurance will help compensate the beneficiary for the value of recruitment charges if the worker ran away or refused to work for the remaining three months of the contract.
The insurance policy covers the domestic worker’s unpaid wages if her sponsor fails to pay her.
Beneficiaries who wish to hire domestic helpers will have the option of securing a recruiting contract.

domain: finance


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If you are looking for vitamin hair loss treatment b6 then read this post through to the end.
However some people might be troubled by hair loss that they feel has actually affected their look. If you stop, any regrown hair will fall out, and you will wind up with the exact same quantity of hair you had when you started treatment. This choice help is about whether to use medication to treat loss of hair. A key element of hair loss with age is the aging of the hair follicle. Ordinarily, hair roots renewal is maintained by the stem cells connected with each follicle.
Because of these known adverse effects, it is suggested that females have routine blood pressure and electrolyte monitoring, particularly in the first couple of months of treatment. Further care with its usage needs to be exercised in the client with renal problems considering that it can possibly cause severe electrolyte disturbances. After the preliminary shock of medical diagnosis, a lot of ladies embrace a variety of coping mechanisms. “Settlement” describes efforts to offset the loss of hair with other physical enhancements such as greater attention to dress in order to develop favorable body images. “Concealment” of loss of hair aims to avoid involved negative body-image sensations. Females might wish to avoid the negative responses from household, friends, and even complete strangers, and may wear hats or wigs to accomplish this. Finally, compulsive activities of peace of mind designed to reduce unfavorable body-image sensations such as excessive monitoring or repairing of one’s hair in front of the mirror may happen.
By blending integrations with natural hair from thinning locations, increased volume of hair is created, which creates the look of a full head of hair. Nevertheless, if it is worn for extended durations, it can cause vitamin hair loss treatment b6, in addition to stress to existing hair, resulting in damage and hair breakage. Various kinds of scalp skin react differentially to different types of camouflaging. In general, for oily to regular skin on the scalp, use of a pushed powder permits excellent absorption and avoids a glossy scalp.
Over-the-counter minoxidil comes in liquid, foam and hair shampoo forms. To be most effective, apply the product to the scalp skin once daily for ladies and two times daily for males. Lots of people prefer the foam applied when the hair is wet. Your medical professional scrapes samples from the skin or from a couple of hairs plucked from the scalp to examine the hair roots under a microscope. This can assist determine whether an infection is triggering hair loss. Trost POUND, Bergfeld WF, Calogeras E. The diagnosis and treatment of iron deficiency and its potential relationship to hair loss.
The dependability of horizontally sectioned scalp biopsies in the diagnosis of persistent diffuse telogen loss of hair in women. A randomized clinical trial of 5% topical minoxidil versus 2% topical minoxidil and placebo in the treatment of androgenetic alopecia in men. Gan DC, Sinclair RD. Occurrence of male and female pattern hair loss in Maryborough. Dawber RP, Sonnex T, Ralfs I. Oral antiandrogen treatment of. Considerable hair loss is seen in over 1/4 of females over the age of 50. Acceptable management of this condition requires a knowledge of possible underlying causes, physical comorbidities, possible differential diagnoses, and the various healing methods available. It likewise needs an appreciation of the potential mental impact of loss of hair on affected individuals, and sensitivity throughout patient consultations.
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You’ll have the ability to resolve your loss of hair by treating the underlying condition. Not only do massages feel wonderful, but they can assist with your loss of hair, too. There are restricted studies to support their efficiency in treating hair loss, however a 2016 review identified that low-level laser treatment is safe and effective https://www.cfcnampa.org/buynow when utilized to deal with male pattern baldness. The Fda has authorized a low-level laser gadget as a treatment for hereditary loss of hair in men and women. A couple of little research studies have shown that it improves hair density.
Some people with alopecia areata might choose accessories, wigs, or cosmetic alternatives to address their hair loss, while others choose not to cover afflicted locations. This type of medication might aggravate the skin and cause a short-term, brownish discoloration of the skin that’s been treated. However, some patients can reduce these negative effects by using anthralin for shorter periods of time, without reducing the treatment’s efficiency. Topical minoxidil is not considered reliable on its own in dealing with patients with extensive hair loss. If an individual’s hair grows back entirely with topical minoxidil, treatment can be stopped. This medication is thought about easy to use and has minimal side effects. If I stop taking the medicine, my brand-new hair growth will fall out.
Since fibers need hair to bind to, individuals with advanced loss of hair typically do better with sprays and creams. The adverse effects profile of spironolactone is possibly more varied compared with other medications, due partly to its additional actions as an aldosterone antagonist. These consist of postural hypotension, electrolyte disruptions, menstrual abnormalities, fatigue, urticaria, breast tenderness, and hematological disruptions.
While loss of hair can be stressful for males, a social approval and understanding of this phenomenon normally allows regular psychosocial performance. On the other hand, FPHL is not anticipated and less understood by society producing sensations of confusion and distress for the female. A research study has shown that 52% of women were very-to-extremely distressed by their loss of hair, compared with 28% of guys (Money 1992; Cash et al 1993). This distress leads to lower self-confidence, a bad body image, feelings of regret, issues with sleep and daily function, and restriction of social activities. The existence of menstrual abnormality or marked acne or hirsutism in a lady providing with FPHL ought to trigger the doctor to examine for an underlying cause, in particular, polycystic ovary syndrome. Rarely, virilizing tumors can trigger hyperandrogenism with a current start of and quickly progressive and extreme hair loss from the scalp.
The Savin scale measures general thinning of the crown scalp, and includes 8 crown density images showing a range from no hair loss to severe hair loss (Phases I-1, I-2, I-3, I-4, II-1, II-2, III, advanced). The ninth and last image in the scale demonstrates frontal anterior recession. Patients with alopecia areata, alopecia totalis and alopecia universalis can be dealt with based on age and severity of the condition. This algorithm outlines an approach that can be utilized from mild to serious forms of the disorder. There are now choices that the patient can decide on what is best for them based on efficacy, expense and negative effects profile.
Scalp biopsy is the very best way to distinguish between CTE and FPHL. Increased hair shedding is common in the early stages of FPHL.
Acute telogen effluvium is a self-limiting event, typically triggered by physical health problem, surgical treatment, blood loss, or crash dieting. Persistent telogen effluvium can be secondary to thyroid illness, systemic lupus, drug intake (Table 1; Sinclair and Dawber 2001) and iron deficiency anemia. Iron deficiency without anemia is not thought to cause hair shedding. Idiopathic CTE is defined by excessive shedding of hair for at least 6 months without visible widening of the central parting. Other causes for scattered hair shedding in females are consisted of in Table 2.
If I utilize medicine to treat my hair loss, I will end up with a full head of hair. You need to take the medications every day, over the long term. Otherwise, any regrown hair will fall out, and you will end up with the exact same amount of hair you had when you began treatment. It may assist to return and check out “Get the Facts.” The medications don’t constantly work. And if they do, you may not get as much hair growth as you expect. Hair coverage tends to improve on the top of the head however not on the forehead location. You won’t have to spend for medicine to deal with the vitamin hair loss treatment b6.
If you stop taking the medicine, the regrown hair will fall out, and you will wind up with the exact same amount of hair you had when you began treatment. There are no risks to your health if you choose not to utilize medicine for loss of hair.
Stage 2 preclinical trials revealed that after 6 months of treatment, there was a 30% increased enhancement in hair count when comparing 0.5 mg of dutasteride with 5 mg of finasteride. Style devices can satisfactorily hide localized or scattered spots of loss of hair and include hats, scarves, bandannas, and turbans. Hair additions and devices include combs and headbands with hair attached to them, ponytails that easily connect to existing hair, and hair scrunchies. For more extensive loss of hair that is too delicate to endure integrations, hairpieces or wigs might be used. Hairpieces include skin-like breathable material and hold the attached hair firmly in position. They are attached to the scalp by either adhesive tape or additionally hair clips for ease of removal at the end of the day.
They can be matched to existing scalp tone, hair texture, and color offering as natural a look as possible. A combination is made of fabric or skin-like product with replacement hair attached to it and gaps through which native hair can be pulled through.
Patients who successfully grow back scalp hair normally need to continue treatment in order to keep the regrowth. Negative effects– inflammation, itching and a rash at the site of application– are common. Topical immunotherapy isn’t extensively offered and is usually carried out and prescribed by dermatologists. The National Alopecia Areata Structure can help you discover an expert who provides this treatment in the U.S. Roughly 40% of clients treated with topical immunotherapy will regrow scalp hair after about six months of treatment. There are numerous therapies which can provide benefits for somebody with alopecia areata, nevertheless there is no single option shown to work for everyone.
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Existing gene discovery research might identify a variety of unique genes that regulate hair development, hair biking, and the hormone-induced changes seen at puberty in the future. This research study may result in topically delivered therapy, targeting vital paths to stimulate hair growth. If these representatives can be incorporated into hair follicle cells, long-term change of hair growth, and resultant trustworthy re-growth of hair might be attained.

domain: health


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The tech industry, which sees net neutrality as necessary to innovation, is already pushing back by lobbying politicians, sending letters of protest to the agency and starting to rally supporters. What has been the impact of the current approach? Pai's proposal expresses support for the "no blocking" rule but seeks comment on whether any of the core net-neutrality rules are necessary.
Huffman also said she used a previous ruling by the 5th U.S. Circuit Court of Appeals as her "road map" for the bill. The amendment was a compromise, brokered between House Freedom Caucus chair Mark Meadows (R-NC) and former Tuesday Group co-chair Tom MacArthur (R-NJ), that garnered enough votes from moderates and conservatives to pass through the House.
United States Steel (NYSE:X) traded down 2.52% during mid-day trading on Friday, reaching $19.74. The rating was downgraded by Cowen & Co on Wednesday, May 10 to "Market Perform". This represents a $0.20 dividend on an annualized basis and a yield of 1.01%. The ex-dividend date of this dividend is Monday, May 8th. United States Steel's dividend payout ratio (DPR) is -6.83%.
Analysts on average expected the company to post a profit of 27.06 billion rupees, according to Thomson Reuters data. Considering above, ITC's net profit is seen at Rs 2,578.1 crore during Q4FY17, increasing by 8.37% yoy but will decline by 2.59% on qoq basis.
According to those who are on the scene in Sicily, this address is very much set up like a Donald Trump campaign rally, complete with the theme from Air Force One playing as it did during the campaign, according to The Associated Press' Jonathan Lemire .
Referring to Modi government's "propaganda blitz", the Congress leader said, "Distraction, propaganda, falsification of facts, intolerance, insulting political opponents, insulting all predecessors, questioning the wisdom of intellectuals have been the hallmark of this government since it came to power".
The opening matchups will be Oracle Team USA against Groupama Team France; Sweden's Artemis Racing against SoftBank Team Japan; France versus Emirates Team New Zealand , the hard-luck loser to Oracle in 2013; and Artemis against Britain's Land Rover BAR, which is skippered by Sir Ben Ainslie.
Modi's Bharatiya Janata Party came to power on May 26 , 2014, after a landslide victory on promises of boosting economic growth, curbing corruption and creating jobs. Supplying steel to remote areas of NE, tapping the high potential rural sector of the region, exploring the government's thrust to improve the nation's connectivity with North-east - all prominently figure on the company's priority list.
American Beacon Advisors Inc. purchased a new stake in shares of Cisco Systems during the first quarter valued at approximately $174,000. Similar statistics are true for the second largest owner, Blackrock Inc., which owns 339,316,584 shares of the stock are valued at $11.35 billion.
O'Reilly has denied those accusations. The hatred for Ailes only intensified when he helped create Fox News in 1996, said O'Reilly, especially as the network started trumping CNN in the ratings and became the dominant force in cable news.
We've developed everything in-house, built the world's first private orbital launch range, and we've done it with a small team". Nine Rutherford engines burning RP-1/LOX and providing 22.3 kN each were ignited and rocket started its flight towards south over Pacific Ocean.
When Moses was dismissed after taking a tumble when challenged by Alex Oxlade-Chamberlain, Chelsea appeared to be facing an uphill task. When 10-man Chelsea drew level through Costa, they could have collapsed, but within three minutes they netted a victor through Ramsey's header.
Yet numerous people working at those social media companies, and in Silicon Valley in general, are not big fans of Trump. "It's a very bad thing, Twitter's role in that", the social media website's co-founder, Evan Williams , told The New York Times .
A number of other hedge funds also recently added to or reduced their stakes in the company. However the company reported $0.22 earnings per share for the same quarter during a year ago. During the same period in the prior year, the business earned $0.23 EPS. The business's revenue for the quarter was up 3.8% on a year-over-year basis.
Stock exchanged hands with the total volume of 7.42 Million shares, as contrast to its average volume of 2.60 Million shares. They now have a United States dollars 3 price target on the stock. While looking at the Stock's Performance, BioPharmX Corporation now shows a Weekly Performance of 40.29%, where Monthly Performance is -9.67%, Quarterly performance is 42.51%, 6 Months performance is 110.71% and yearly performance percentage is 0.21%.
Amazon.com's two grocery pickup sites in Seattle have emerged out of "beta" mode - and can be used by members of the company's Prime loyalty program. In Todd's case, he was able to pick up his groceries about three hours after ordering them. AmazonFresh Pickup is just the latest but also least ambitious attempt by the online retail giant to have a physical presence.
Roth Capital set a $23.00 target price on shares of Callon Petroleum Company and gave the company a "buy" rating in a research report on Wednesday, February 22nd. Therefore 30% are positive. It increased, as 22 investors sold Callon Petroleum Company shares while 59 reduced holdings. Imperial Capital maintained it with "Outperform" rating and $18 target in Friday, September 30 report.
It may be used by market technicians to enter and exit trades, and it is a useful tool to add to a trading system. Continental Building Products Inc (NYSE:CBPX) has risen 13.56% since May 26, 2016 and is uptrending. Lexington Realty had 9 analyst reports since September 8, 2015 according to SRatingsIntel. The firm earned "Hold" rating on Monday, September 21 by Craig Hallum.
Before the G7 meeting, several ministers and officials held an early-morning discussion of Greece's long-running debt crisis to prepare for a May 22 meeting of euro zone finance ministers on the disbursement of new loans. Treasury Secretary Steven Mnuchin. It "politically became impossible to sustain" the perception that workers are being taxed "and the big guys, the multinationals are not paying their fair share", he said.
The stock of Petroleo Brasileiro SA Petrobras (ADR) (NYSE: PBR ) has "Overweight" rating given on Tuesday, August 11 by Barclays Capital. JP Morgan downgraded the stock to "Neutral" rating in Friday, September 11 report. Her Majesty The Queen In Right Of The Province Of Alberta As Represented By Alberta Inv Mgmt Corporation owns 214,700 shares. Baldwin Brothers Ma has invested 0.19% of its portfolio in Pfizer Inc.
The downgrading of the China's credit rating has anxious the metal investors globally and domestically. "It, as we all know, is capitalist with Chinese characteristics", Alpert said. Moody's ratings agency downgraded China's credit score on Wednesday, warning that economy-wide debt is expected to rise as potential economic growth slows over the coming years.
Numerous company's popular gadgets, including Kindle eReaders, Fire TV devices, Fire tablets and, of course, the Echo and its smart assistant Alexa, dominate a space towards the front of the store to highlight Amazon's growing devices group.
Several other institutional investors have also modified their holdings of the company. This leaves us with a quarter on quarter earnings per share growth of 6.50%. The firm had revenue of $11.41 billion for the quarter, compared to analysts' expectations of $12.09 billion. During the same period in the prior year, the firm earned $0.41 earnings per share.
SigmaTron International, Inc.is a provider of electronic manufacturing service, which includes printed circuit board assemblies, and assembled (box-build) electronic products. CBG's profit will be $177.50M for 15.34 P/E if the $0.54 EPS becomes a reality. After $-1.26 actual earnings per share reported by La Jolla Pharmaceutical Company for the previous quarter, Wall Street now forecasts -12.70% EPS growth.
On the other hand, another writer focused on the Trump embrace as just a way to suck Israel into his grand plans to bring about peace in this part of the world. I hope that when they hear the words of the president , they will be moved to see a brighter future for their children. The administration naively believes that the solving Israeli-Palestinian conflict, not stopping Islamic supremacism, is the key to peace in the Middle East .
The BSE listed company saw a recent bid of 12.60 and 2080 shares have traded hands in the session. Managing Director, UK, Hobbs Sebastian, purchased 500 common shares of Signet Jewelers Limited (SIG ) in the open market. will post $7.00 earnings per share for the current year. Several hedge funds have recently made changes to their positions in SIG. King Luther Capital Mngmt reported 2,355 shares.
CRUDE CUT: Oil prices bottomed out after a sharp selloff triggered by a deal by an alliance of oil-producing nations to extend production cuts for nine months to shore up crude prices. Most European benchmarks climbed after an early wobble. Khalid Al-Falih said he expected a "healthy return" for US shale and remained defiant that a boom in USA shale won't derail OPEC's effort to tackle the demand and supply imbalance.
The number of shares traded in the last trading session was 2.56 Million. Finally, Lucus Advisors LLC increased its stake in shares of Rayonier Advanced Materials by 13.6% in the third quarter. They expect $0.22 EPS, down 52.17% or $0.24 from last year's $0.46 per share. Tembec shareholders are being offered $4.05 in cash or 0.2302 of a Rayonier share, subject to a cap on the total amount of cash or shares that will be issued.
The biggest problem, though, was a staggering $2.2 billion in losses, up from just $104 million in the same quarter a year ago. The operating expenses for the quarter were $196 million. A closer look at Snap's revenue numbers also likely won't calm the markets. Its average revenue per user (ARPU) was $0.90, up by 181% from $0.32 in the same period previous year.
The company was downgraded on Tuesday, May 3 by Canaccord Genuity. Analysts have a mean recommendation of 2.00 on this stock (A rating of less than 2 means buy, "hold" within the 3 range, "sell" within the 4 range, and "strong sell" within the 5 range).
He said there was "no way that the tens of billions of pounds of tax rises they promise" could be borne by the top 5% of earners and big business. Mr Emmerson said: "For Labour we can have pretty much everything - free higher education, free childcare, more spending on pay, health, infrastructure".
The allies hoped that it would prompt Trump to reassure them of United States commitment to uphold the aliance's collective defence pact, known as Article 5 , which enshrines NATO's founding principle that an attack against one ally is considered as an attack against all allies.
When the market opened the shares jumped, trading nearly 30 per cent higher, up 96½p at 421¾p approaching noon. Mr Page and Mr Denton have sold 26pc of the company, just above the 25pc threshold required for a premium listing on the stock exchange.
However, the next day Trump tweeted that he would still terminate the agreement " if we do not reach a fair deal for all ". "Since the signing of NAFTA , we have seen our manufacturing industry decimated, factories shuttered, and countless workers left jobless", Ross said.
In the currency market , the euro EUR= traded up 0.1 percent in Asia at $1.1225, having bounced back from Wednesday's low of $1.1168 and coming within sight of $1.1268, its 6 1/2-month high set on Tuesday. The Canadian dollar strengthened to a five-week high of C$1.3402 per US dollar CAD=D4 after the Bank of Canada was more upbeat about the economy than some investors had expected.

domain: economics


Spinifex stories catalogued
A catalogue detailing the stories behind a number of indigenous paintings was launched in Port Hedland last week.
The main gallery space at the Port Hedland Courthouse Gallery was packed with people for the Art After Dark event, which also doubled as the launch of the We Call It Home catalogue showcasing the work of Spinifex Hill Studio artists, who are based in South Hedland.
Studio manager Greg Taylor told the crowd he was really proud of the quality of work the artists had produced since moving into the purpose-built studio in March last year.
He said the catalogue was another way of documenting the stories behind paintings included in the current exhibition.
“I love hearing the stories, every painting has a wonderful story, ” he said.
Artist Teddy Byrne has spent the past 12 months honing his skills and developing his artwork with the Spinifex Hill collective.
He said he was proud to have one of his stories and paintings included in the catalogue.
“It’s great … I didn’t think I could do a painting like this one, ” Byrne said.
“… My mum would be very proud.”
During the Art After Hour event, attendees also heard from Wangka Maya linguist Jason Lee about the number of indigenous languages in the Pilbara and the processes involved in recording and preserving these.
Mr Lee also spoke about how stories included songs and art work.
“Everything goes together to create a story, ” he said.
The ABC’s Susan Standen outlined the story behind the ABC Open photographic exhibition that has run alongside the indigenous artworks.
She encouraged attendees to get involved in recording and documenting their own Pilbara stories whether through writing, photographs, videos or other mediums.
Local musicians David Clarke and Jan Gillingham entertained the crowd with acoustic music before jamming with some of the Spinifex artists in the courtyard.
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CITY HALL BUREAU CHIEF
When Rocco Rossi vowed to banish bike lanes from major streets, the suit-and-tie crowd at the Empire Club event erupted into its most enthusiastic applause yet for the first real speech of the 2010 mayor's race.
The line demonstrated that Mr. Rossi knows whom he's after: right-leaning suburban voters fed up with David Miller's city hall.
Mr. Rossi is promising to halt all but one of the city's planned light-rail lines until he can review the project's finances; to replace the Toronto Transit Commission's board of councillors with private-sector experts; to create a region-wide economic development corporation; to sell assets, including Toronto Hydro; and to outsource city work in a bid to decrease the power of unions.
"Make no mistake, last summer's city workers strike showed just how weak the city has become in the face of its major unions and how utterly without a plan we are to correct this imbalance," the former Liberal fundraiser and businessman told a packed room at the Royal York hotel. "As mayor I will bring us back into balance by pursuing outsourcing and managed competition for certain city services."
Mr. Rossi's speech was unusual for making concrete commitments early in the marathon campaign, leaving his competitors 10 months to savage his proposals. They didn't waste time.
"I'm glad to see he's throwing out 1,000 ideas and seeing what sticks," scoffed Joe Pantalone, the deputy mayor who is running to replace his boss. "But this is not a carnival we're talking about here. This is a city that's complicated."
Mr. Rossi drew the most fire for suggesting he might halt the Transit City plan, even temporarily.
In his speech, Mr. Rossi lamented the delays and cost overruns that plagued the construction of a streetcar right-of-way on St. Clair West, but it wasn't until afterward that he expressed his concerns about Toronto's plan to lay 120 kilometres of light rail on dedicated lanes.
"I think there's some real problems that have been shown by what's happened at St. Clair and I think we'd be foolish not to have a deep and long look at that," he told reporters.
Asked whether that constituted a moratorium, he replied: "On anything that we can stop right now, yes." Only one Transit City line, Sheppard East, has broken ground so far.
"Mr. Rossi's suggestion that he would freeze all new transit projects until he has reviewed the city budget would not only put countless constructions jobs at risk, it reflects a troubling lack of understanding of the city's finances," a senior member of George Smitherman's campaign said. "These projects are funded almost entirely by the province, sometimes with federal help." Mr. Smitherman, the former deputy premier, is the race's early front-runner.
The centre-right voters Mr. Rossi is hoping to attract likely would have voted for former Ontario Progressive Conservative leader John Tory.
But Mr. Rossi will have to run a campaign vastly different from Mr. Smitherman's if he hopes to make the leap from virtual unknown to mayor. For now, he's casting his lack of elected experience as an advantage.
"It's been over a hundred years since we elected a mayor who wasn't already in elected politics," he told the crowd. "Maybe, just maybe, that's part of the problem."
What would Rossi do?
- Ban future bike lanes on major arterial roads, and "look at" removing existing bike lanes on those major thoroughfares
- Put private-sector experts on the TTC's board, replacing councillors
- Freeze all but one planned light-rail line until he reviews the project's finances
- Create a GTA-wide economic development corporation
- Prepare long-term operating budgets
- Sell Toronto Hydro and put the proceeds into debt reduction; examine selling other city assets
- Look at outsourcing more city services
- Distribute the extra money developers often pay for exemptions from zoning rules - known as section 37 funds - to 13 poor neighbourhoods in the inner suburbs through a "city builders" fund.


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Global Small Wind Turbines Market-Polaris America, Endurance Wind Power, Britwind, HY Energy
Global Video Conferencing Endpoint Market 2017- Polycom, Huawei, Avaya (Radvision) and ZTE
Global Hair Loss&growth Treatments and Products Sales Market- Gamble, L’Oreal, Unilever, Taisho, Henkel, Merck
Global Automotive Gear Shifter Market 2017- Sila, ZF, SL Corporation, Kongsberg and GHSP
Global Shirting Apparel Fabrics Market 2017- Veratex Lining, Acorn Fabrics, Rughani Brothers and Sarvoday Textiles
Global Crystalline Silicon PV Cells Market Size 2017- Canadian Solar, Hareon Solar, Hanwha, Kyocera Solar, TongWei Solar
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Global Zirconia Market 2017- Innovnano, Solvay, KCM Corporation, Saint-Gobain, Tosoh and MEL Chemicals
Global Hydrotalcite Market-Heubach India, Kyowa Chemical, Sasol Germany, Kanggaote
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Global DTH Drill Market 2017- Atlas copco, Borat Lonyear, Mincon, Rockmore and Sandvik
Global Entertainment Centers & TV Stands Market 2017:2022- Redapple, QuanU Furniture Group, QM and Ashley Furniture
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Global High Selenium Yeast Market 2017- Novus International, Angel, Lesaffre, Alltech and Lallemand
Global Sink Market 2017:2022- Franke, Elkay, America Standerd, Kohler and Blanco
Global N-methyl-pyrrolidone Market 2017- Mitsubishi Chemical, Londellbasell, Dupont, BASF and Ashland
Global Polyisobutenyl Succinic Anhydride (PIBSA) Market 2017- Afton, Pentagon Chemicals, Clariant, Chevron and Orica
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Global Electroencephalography Equipment Market-Philips Healthcare, Natus Medical, EBNeuro, SCHILLER
COPYRIGHT - 2017 JOURNALISM DAY

domain: geography


text:
Taylor Swift took home two trophies last night and an amazing “in your face” performance of her single “Mean”. Her song was unquestionably a crowd pleaser that ended with a full standing ovation. While most of us knew Taylor would rack in the trophies (just as the rock world new Adele would) Taylor looked genuinely shocked at both the standing ovation by her peers and the titles “Solo Performance” and “Best Song”.
Before the show, Taylor was interviewed by Ryan Seacrest who asked questions like ” How do you prepare for the future and stay on pace when your fame is so big” , “Are you afraid of things falling apart because you rose to fame so quickly?” Taylor responded by saying shes neurotic about her work and planning for the future and she hopes she can evolve with her fans and continue doing what she love best.
Catch Taylor Swift tonight on Mtv at 7:54 for the world premier of her new song from The Hunger Games movie. If you miss it, it re-airs on CMT.
The Civil Wars will also appear on the soundtrack from The Hunger Games performing with Taylor Swift. Haven’t heard of The Civil Wars? Their fame is rising just as quickly as The Band Perry. Last night the Civil wars won 2 Grammys, one for “Best Folk Album” and one for “Best Duo/Group”, locking out Country music ‘Greats’ like Kenny Chesney, Jason Aldean, and the new duo Thompson Square. The Civil Wars are currently touring the UK, but check out future tour dates @ http://www.thecivilwars.com. Click here to hear the Grammy Award winning song “Barton Hollow” .
Other big winners last night include Alison Krauss and Union Station (for Bluegrass Categories) and Lady Antebellum. Lady Antebellum was awarded for “Best Album of the Year” and attributed much of their success to their cross-over type image.
Photo of The Civil Wars

domain: celebrity


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As music festival season gets underway, a lineup of acclaimed blues artists is again taking over the Coeur d'Alene Resort, offering great views to complement the music. For the past eight years, the Coeur d'Alene Blues Festival has brought together regional and touring bands that specialize in the most American of musical genres, and they perform all over the resort — in the convention center, on the roof, in the lounges and restaurants, even on the water.
Craig Heimbigner, the festival's founder and director, estimates that the event draws 1,200 or so dedicated blues junkies to North Idaho. They've formed something of a community, he says, meeting up in Coeur d'Alene every year, then meeting up again at other blues festivals later in the spring and summer.
"I think people are just thrilled to come out," Heimbigner says. "They've been cooped up all winter, and now this blues crowd gets to come out and have fun."
Here are a few of the artists and events you can look forward to this weekend:
Now an annual staple of the Blues Festival, the Friday night Blues Cruise takes the live music out onto the tranquil waters of Lake Coeur d'Alene at 7 pm. For $25, you can board one of two boats, where the Bobby Patterson Band and the Kenny James Miller Band will perform.
"There's music going on both boats at all times, and you can go back and forth," Heimbigner says. "It's always a party."
Patterson's band will perform again on two separate Saturday cruises, new to this year's festival, at 12:30 and 2:30 pm. Tickets are $10.
A UNIQUE VOICE
This year's main stage headliner will be familiar to regular viewers of the NBC reality-TV singing competition The Voice. With his shoulder-length hair, bushy beard and John Lennon spectacles, Laith Al-Saadi really stuck out from the mob of contestants vying to be the next big pre-packaged pop star.
The Ann Arbor, Michigan-based singer-songwriter made it to the top four during the show's 10th season, and although he didn't end up winning, he certainly made an impression. Al-Saadi's blind audition, a gritty, growly take on Joe Cocker's version of "The Letter" (complete with a show-off guitar solo), especially impressed Voice judges Blake Shelton and Adam Levine, the latter of whom became Al-Saadi's mentor throughout the season.
But Al-Saadi wasn't some amateur who NBC talent scouts just picked up off the street: According to the guitarist himself, he's been playing 300 or so shows every year for the past two decades, and he majored in guitar at the University of Michigan.
"He's a great player, he's got a lot of personality and he has a different audience," Heimbigner says. "He isn't just known to the blues crowd, so he has this crossover thing."
Before Al-Saadi hits the main stage on Saturday night, you can check out the folk-tinged blues of the Stacy Jones Band from Shoreline, Washington, the Southern-fried rock of Portland's Ty Curtis Band and local favorites Robin Barrett & Coyote Kings. Following Al-Saadi's performance, the Sara Brown Band will provide the entertainment at a late-night afterparty.
BLUES WITH YOUR BRUNCH
On Sunday morning, you've got two chances to enjoy some music while also enjoying Coeur d'Alene Resort's fine dining. At 10 am, the Joyous Praise Gospel Trio will take you to church during brunch in the resort's Dockside Restaurant. Tickets are $32.95 (yes, that includes brunch). Another lake cruise takes off at 11 am, this time with a full brunch menu and an acoustic performance from the Ty Curtis Band. ♦
Coeur d'Alene Blues Festival • Fri-Sun, March 31-April 2 • $5-$60; prices vary per event • Coeur d'Alene Resort Convention Center • 115 S. 2nd St. • cdabluesfestival.com for full schedule • 208-765-4000 ext. 21

domain: entertainment


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The Local Girl Gang - Design Project: Blank Slate LNK
This month we are showcasing Sara Schaepe, the designer and creator behind Blank Slate LNK a brand located in Lincoln, Nebraska that is dedicated to the belief that everyone is wildly capable. The idea behind Blank Slate LNK is that every day we are given a blank slate to do, create, and be what our hearts greatest passions are. It’s fueled by the idea that we are all capable of greatness and that greatness looks different for everyone. Being wildly capable means that we are passionate dreamers with a fierce nature inside of us. Check our her goods. Buy some beauties. then pop to her site at blankslatelnk.com and snap up even more! click HERE
Also NAB her FREEEEEEEE downloadable booklet just for us HERE
The Local Girl Gang is collective full of woman bosses, leaders, students, mamas, makers, activists, artists, creators and most importantly supporters. We hold collaboration over competition so closely to our hearts and want it to drive everything we do. our goal is to help, encourage and empower real voices to start conversations.
Each month we are highlighting a different artist and showcasing their work. Each artist has lavishly donated a few pieces to the Collective to help the Girl Gang raise funds, We are a group currently made purely of volunteers and volunteered time.
SO!! We thought this would be a fun way to encourage collaboration and artist support. We only have a very few of each item, and when they sell out we encourage you to support these beautiful artists directly by popping into their shops, buying this merchandise from them, as well as snagging some of their other beautifully designed and produced products.


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Most people spend a lot of money getting their homes to look the way they want them to, but the results aren’t always successful. Only about one out of every five Americans is happy with the home decor they have, and 14% even say their home furnishings make them feel downright gloomy. To try to make your home a more happy place, you might have to think outside the box and do some home decorating that you normally wouldn’t have thought of.
If you are one of the nearly half of all people who haven’t update their home decor in the past five years, it may be time for a radical change. If being by the ocean or a lake makes you happy, you might consider doing nautical decorations in your home. Nautical decor could in (more…)
21 Apr 2017