rotary vibrating screen screen
Rotary vibrating screen - Xinxiang Dayong Vibration Equipment Co ...
Rotary vibrating screen mainly used for screening powder and granule material, high precision can be reach 500 mesh. We are factory directly accept customized service, it can satisfy different clients' request.read more
Rotary vibrating screen - Xinxiang Yongqing Screen Machine Co., Ltd.
XZS Rotary vibrating screen is a high performance fine screening machine, used mainly for sieving, scalping, removing impurity, grading and filtering to improve product quality. Our team has rich experience for its usage in food, chemical, ceramic, medicine, metallurgy, pollution abatement.etc. The rotary vibrating screen...read more
Rotary Vibrating Screen|Screening Machines|Henan Pingyuan ...
Introduction Rotary vibrating screen is designed as a high-precision screening machinery, it is composed of a upper cover, a screen box, a base and a vertical motor with eccentric weight installed at two ends. Rotary vibrating screen can be produced in horizontal, vertical, inclined motions by adjusting the upper and lower...read more
24 best Rotary vibrating screen images on Pinterest | Rotary ...
Explore Anne Guo's board "Rotary vibrating screen" on Pinterest. | See more ideas about Rotary, Screens and Html.read more
Rotary Vibrating Screen-China Xinxiang Hongyuan Vibration ...
Three-Dimensional Vibrating Screens also known as Rotary Vibrating screens are a general-purpose vibrating screening and filtering device with wide application in powder small-sized and liquid materials.read more
SF Type Electromagnetic Screens. Best suited for fine powder treatment in food and chemical industries. P.7. RVS Type Rotary Vibrating Screens. Operable in wide area, from food to steel industries. P.9. SMVCB Type Balanced Screens. Sift and convey at the same time. P.11. SBM Type Perfect Balance Screens.read more
Rotary Vibrating Screen - Henan Winner Vibrating Equipment Co., Ltd.
Rotary Vibrating Screen is a kind of high precision fine powder screening machine, low noise, high efficiency, full closed structure, suitable for granular, powder, mucus and other materials screening and filtering.read more
coal stone rotary vibrating screen for sale - ZNTH crusher
types of rotary crushers in mining aicso.org. The vibrating screen is a kind of sieving The Rotary Coal Breaker crushes Mobile Crusher machine in Japan,price for sale Stone Crusher plant in . size. Check price. Ball Mill Screens South Africa Crusher Mills. Ball Mill Screens South Africa. and screen for sale in south africa coal...read more
Vibrating Screen - Prater
Prater's vibrating screen capabilities reflect over 90 years of engineering experience in the design and construction of efficient, reliable and economical equipment. Our Vibrating Screens have built an enviable reputation for continuous long-life service, high productivity and dependability. Adjustability is the key to Prater...read more
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Vibrating Screen Manufacturers sale indiaStar Trace Pvt. Ltd. Design, Manufacturers, Suppliers and Exporters of vibrating screen for sale in Chennai,Gyro screen separator or vibro separator is purely an industrial equipmentRotary & circular motion initiated by motor spreads the fed matter across theScreens are new...read more
ANALYSIS OF SIEVE HOLES BLOCKING IN A VIBRATING ...
of Mineral Processing www.minproc.pwr.wroc.pl/journal/. ISSN 1643-1049 (print). ISSN 2084-4735 (online). Received May 17, 2016; reviewed; accepted September 6, 2016. Analysis of sieve holes blocking in a vibrating screen and a rotary and drum screen. Katarzyna Lawinska*, Remigiusz Modrzewski**. * Institute of...read more
Case Study: STM Vibrating Screens | General Kinematics
Apr 19, 2011 ... Challenge Customer wanted to replace an existing vibrating screen due to frequent mechanical failure issues. Existing screen technology utilized the traditional brute force drive with large shafts, bearings, and motors. In the application, brute force screen technology typically had a useable life of around 1...read more
2 Answers - What is Vibrating Screen? - Quora
The vibrating motor and rubber sieve plate are the internal components of the vibrating screen. High frequency vibrating screens are primarily utilized in the mineral processing industries. Different vibrating screens are available in the market such as circular vibrating screens, gyratory screen, rotary vibrating screen, trammel...read more
China Vibrating Screen, Vibrating Screen Manufacturers, Suppliers ...
26968 products ... China Vibrating Screen manufacturers - Select 2017 high quality Vibrating Screen products in best price from certified Chinese Screen Machine manufacturers, ... Description of two layers stainless steel screening machine rotary vibrating screen We are engaged in manufacturing screening machine that is...read more
Mechanical screening - Wikipedia
A screening machine consist of a drive that induces vibration, a screen media that causes particle separation, and a deck which holds the screen media and the drive and is the mode of transport for the vibration. There are physical factors that makes screening practical. For example, vibration, g force, bed density, and...read more
CIRCULAR VIBRATING SCREEN - ERIMAKI - PDF Catalogue ...
The ERIMAKI vibrating screens provide good results and are easy to use, at truly competitive costs. The wide range of models (from Ø 400 to Ø 2200 mm) can meet any type of requirement. Besides manufacturing and selling screens and circular vibrating screens, sieves and electrical sieving machines, rotary separators...read more
Circular vibrating screen - ZHENYING - Vibrating Screens
Application. Various kinds of the materials can be screened by the machines including those within 0~400mesh like dry, wet, refined, coarse, heavy and light as well as those within 0~600mesh like liquid and pasty materials. rotary vibrating screen operation principle...read more
High Quality GS Series Rotary Vibrating Screen ,Drum Screen For ...
Our excellent and advanced high quality gs series rotary vibrating screen ,drum screen for sale is of high-quality and already gotten strictly test. It has already been sold home and abroad and received strong reputation. Welcome to purchase our quality products.read more
Mogensen Vibrating Screens
The vibrating screen range covers both rotary and linear action drives to accommodate different applications, open or enclosed bodies, single length or double length decks and light to heavy duty design. Single to multi deck configurations, wire mesh, polydecks, rubber mats to specials with bespoke outlet designs.read more
Vibrating Screen,Vibrating Screen supplier,China vibrating screen ...
Vibrating Screen is one of the unique product or equipment, it is used for separating the stuff.read more
Matches' Screen cost - vibratory, grizzly, rotary, stationary, trommel.
Vibrating Screen,Vibration Sieve,Circular Vibrating Screen ...
A professional manufacturer of Vibration Sieve,linear vibrating screen,ultrasonic vibrating screen,lab vibrating screen,etc-SANCHEN vibrating machinery.Were born to making your Sieving easier!read more
Screening Feeders and Screens - Syntron Material Handling
Link-Belt® Models UP, VC and NRM Inclined Vibrating Screens are backed with over 50 years of proven, dependable performance in industry. Continuing Vibrating Screen design improvements by our research and development engineers have enabled these rugged units to solve a greater range of difficult screening...read more
vibrating screen - 3D CAD model - GrabCAD
Feb 9, 2013 ... Tebja ja vigy shto interesyet betonie machine. 22 Feb 2015 2:12 PM. Community; Library · Challenges · Questions · Tutorials · Engineers. Workbench; Overview · Features · Compare. Print; Overview · Features. Resources; Blog · Resource Center · Help Center. About us; Company · Jobs.read more
rotary vibrating screen from Xinxiang Gaofu Sieving Machinery Co ...
Xinxiang Gaofu Sieving Machinery Co.,Ltd .'s, rotary vibrating screen . rotary vibrating screen wholesale, manufacturer and supplier. Visit for more information on high quality China products.read more
China Vibrating Screen Manufacturers, Factory, Wholesale - Beijing ...
If you are going to wholesale cheap and good quality mining vibrating screen from one of the leading shale shaker, shaker screen, mining screen, screen machine, stack sizer manufacturers or ... The screens are composed of two sections of screen mesh with different inclination angles. ... HYS Rotary Mobile Screen Series.read more
Vibrating Screen Manufacturer from Delhi
Manufacturer and Trader of Crushing and Screening Equipments, Vibrating Screens, Jaw Crushers, Industrial Screening Equipments, Industrial Vibrating Screens, Industrial Jaw Crushers ... Prominent & Leading Manufacturer from Delhi, we offer single deck vibrating screen, double deck vibrating screen and rotary screen.read more
Vibrating Screen Working Principle - 911 Metallurgist
Aug 2, 2017 ... When the smaller rock has to be classified a vibrating screen will be used. The simplest Vibrating Screen Working Principle can be explained using the single deck screen and put it onto an inclined frame. The frame is mounted on springs. The vibration is generated from an unbalanced flywheel. A very...read more PRE Post:roller crusher iron ore crusher
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Can any British Government be trusted to do what they say?
As William Hague now urges Tories to oppose EU referendum vote
William Hague has urged Tory MPs not to vote for a referendum on the UK remaining in the EU, saying it would be a distraction, yet this goes against the very pledges this government took to get elected into power, Nikki Sinclaire handed in 100,000 names to Downing Street calling for a public vote, is the British government going to dismiss the voices of England that want out of the EU? Hague says it will be a distraction, rubbish it will be far less of a distraction not being part of it? Wear this British government could fully concentrate on business here rather than spend most of its time worrying about the EU and having to spend billions of English taxes each year keeping fat cats sitting on their fat backside doing nothing to help England but burden us with their EU rubbish
On Monday, MPs are due to debate a motion which calls for a referendum to be held on UK membership of the EU.
Writing in the Daily Telegraph, Mr Hague said solving the euro-zone finance crisis should be the priority, what he forgot to say? is that the crisis couldn’t be solved, but trying would cost English tax payers billions of pounds trying when England is already severely burden with cuts in public spending Hague wants to burden England even more, well it’s very ok for the likes of Hague and the rest of the British MP’s that are making millions of pound each year, but it wouldn’t be for middle and low income earners will it? With more and more taxes and public service cuts to fund the EU and its euro mess?
He said a referendum would add to economic uncertainty when businesses need all the certainty they can get, what another load of rubbish it would be far better for English businesses and cost them far less if we pull out of the EU, Hague just wants like others to line his own pockets.
Hague’s spin, a half-witted prominent Eurosceptic, wrote: "As a Conservative, I want to bring powers back from Europe, as we set out in our election manifesto.
"But a referendum on England’s membership of the EU, especially at this time of profound economic uncertainty, is not the answer."
The half-wit added some more rubbish saying: "Nothing would do more to help our economic recovery than a resolution of the Euro-zone’s difficulties, while its disorderly break-up would have a very serious impact on our economy."
The Conservatives, the Lib Dems and Labour will all ask their MPs to oppose the motion calling for a referendum to be held on UK membership of the EU.
The motion calls for a referendum by May 2013 and says the public should have three options put to them in the nationwide vote - keeping the status quo, leaving the EU or reforming the terms of the UK's membership of the EU and if England is still a democracy under British rule then a vote must be put to the people but if England has become a dictatorship England won’t get the vote and civil war could be next as there are many Englishmen and women that will not stand by and let the British government dictate, when there has been overwhelmingly support for a vote in England and Cameron and other British MP’s could be the cause of the next civil war in England.
English campaigners for a referendum are due to hold a day-long meeting in Westminster to try to gather more English public support already reaching over 100,000 plus people.
A large number of MPs are expected to back the proposal, which was put forward by Tory MP David Nuttall, although a vote in favour would not be binding on the British government but would most certainly lead to un-rest in England if they didn’t hold to the pelages they made to get into power.
In the coalition agreement, the Conservatives and the Lib Dems, a traditionally pro-European party, agreed to "ensure that the British government is a positive participant in the European Union, playing a strong and positive role with its partners".
On Friday, The Humpty Dumpty Deputy Prime Minister Nick Clegg said it was the worst time for a debate about Britain leaving the EU as a "firestorm" engulfs the Euro-zone. (And if England stays in the EU that same firestorm that engulf the Euro-zones will engulf England)
Nikki Sinclaire MEP on petition for EU referendum a former UKIP, now independent, MEP went across the country championing the call for a referendum on the UK remaining in the EU.
Nikki Sinclaire handed in 100,000 names to Downing Street calling for a public vote and was joined by many Conservatives and Labour MPs who want a vote in the House of Commons.
Former minister Tony McNulty said there should be a referendum as they discussed why Tory and Labour governments had failed to deliver on their pledges to offer votes on the EU. (Will England become the next Libya as the ENA started a weekend exercise on the Southdown’s with more than 300 southern troops taking part, many Sussex counties seeing English troops in its towns and railway stations for the first time in English history since the Civil War led to the trial and execution of Charles I, the exile of his son, Charles II, and replacement of English monarchy with first, the Commonwealth of England (1649–53), and then with a Protectorate (1653–59), under Oliver Cromwell's personal rule.)


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Leather bound journal 13 x 21 cm, containing handwritten notes, poems, newspaper clippings. Binding broken. Newspaper clippings: Australian Ode Competition 1913 -- Aladdin's Pastepot -- Remember the Waiter -- The Queen's Jubilee -- To Wolsley all authored by 'CROMWELL'; The Peace Soceity -- Imprisoned in his chimney -- Quelled by a bike various clippings from the Sunday Times 1899, many authored by 'Uncle Billy', 'UB' and 'The Goat'; Psychic Pianist -- Poor Humanity -- National Song Competition. Poems: The Twins -- The Danube -- The Lady Pharisee -- Sydney Harbour and the meeting of the waters -- Welcome Earl Beauchamp (Sydney 24/4/1899 GW) -- The Capitalist -- Coronation of King Edward VII (June 29 1892) -- Home rule for Old Ireland (12 June 1902) -- The Water and Sewerage Board -- Pity me -- The Nun and the Cardinal -- Ode to Australia (25/8/1913) -- Congenial souls (illustrated) -- On the revision of the New Testament -- Love -- Oh the happy days of childhood -- To give you a glimpse of a heavenly kiss. Songs: Patriotic song -- A young Cockadoodle . . . Old Brown. Plays: Ali Cogia or The Fraudulent trustee by GWR -- King Harold a play in three acts by GWR  -- Out of the ranks. Manuscripts: Our tricycle ride to Harwick [Sept 27th 1890] -- The Burglary in Arcadia -- [indescipherable by Tidy-fol-lol] -- Marion -- Never more -- Duet -- The Farmer's wife and the geese -- The MP and his voter -- Lie-water and the Chinaman -- The Prior of Cosmo -- Jack and the mermaid -- An amusing episode. Music: Patriotic song.
Rowley, G. W.

domain: library


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Rye – Scott Brown kicks off his “Main Streets & Living Rooms” tour with a total of six stops and meetings with grassroots leaders across New Hampshire.
In addition to the open press events below, Brown will also have meetings with activists and elected officials in Dover, North Conway and Intervale.
in Nashua, Brown announced he was forming an exploratory committee for this fall’s Senate race, and would be spending the next few weeks traveling across the state, meeting with New Hampshire residents and listening to their concerns.
Saturday, March 15, 2014
WHAT: Scott Brown meets with residents at the Pink Cadillac Diner
WHERE: 17 Farmington Road, Rochester
WHAT: Scott Brown meets with activists and community leaders at Lino’s Restaurant
WHERE: 3 High Street, Wakefield

domain: news


Chip Tuning Performance MERCEDES CLK320 C209 3.0 CDI 224 HP CR Power Box
- Item condition:
- Time left:
- Item location:
- Ships to:
- Manufacturer Part Number:
- 2 Year
- Country/Region of Manufacture:
CR1 chipbox is digital device designed for diesel cars that include a common rail injection system (CR).
CR1 chip should be plugged into cars electrical system what causes the modification of the data exchanged between the computer ECU and each engine component when it comes to:
- fuel injection,
- fuel amount,
- boost pressure,
- air temperature,
- air density,
- engine speed,
- throttle position, and other variables.
- Chipbox increase power up to 30% - power increase depends on the engine volume and cars power output - it may result in 20 horse power more in a small engine or even 50 in bigger diesel engine.
- Chipbox increase of torque from 30 to 50 NM.
- Car reaches higher maximum speed, better acceleration, better dynamics and responds better for the gas pedal.
- In diesel engines decreases fuel consumption by 0,5 to 1,5 liter per 100 KM.
- Eliminates so called "turbo hole" in cars with turbine.
- The electronic circuit of the chip is flooded with epoxy resin, waterproof, perfectly protected from moisture, dust, oily coating.
- It has a motor protection function (this function prevents overheating of the engine under heavy load - a very dynamic driving).
- Digital chip is made from good quality materials, and the wires are placed in the heat-resistant ducts - made in SMD technology.
- It doesn't cause excessive fumes emanation.
- After removing the chip the car returns to factory settings
Fast and easy installation „PLUG&PLAY” - takes only a few minutes.*
(* there are some cars where the plug is located behind the engine or any other hard reachable places what results in much more effort to perform the assembly. Sometimes there is mechanical help needed because for instance the battery or air filter has to be removed to reach the plug - such models are very rare ones).
You will receive the device ready for installation with detailed instructions!
The device has an additional adjustment in the form of adjusting screw, which helps to conform the device for operating the engine - use it only when necessary. Please contact with us before use additional regulation.
Our production meets the highest standards of an international association of producers of the electronics industry IPC as well as Polish and international production standards.
IPC certifications are recognized worldwide as a guarantee of quality of products and services in the electronics industry. The use of the production standards IEC guarantees high quality and repeatability of the production process.
- AFTER PURCHASE PLEASE LET US KNOW:
- THE MAKE
- THE MODEL
- THE CAPACITY OF THE ENGINE
- THE YEAR OF PRODUCTION
- THE POWER IN BHP
For the each purchased device you will get 24 months warranty. The warranty covers replacement of the device with new or repaired device. Our products can be returned. If you are not satisfied with the device, you can return it within 14 days from the date of receipt of the shipment,and I will refund the cost of the device. Shipping costs paid by the buyer. Shipment should be sent to the address of our factory: ProRacing X ul. Wroclawska 261, 59-220 Legnica, Poland. Please email before you return it. The most important for me is the satisfaction of the buyer.


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Advanced Sulforaphane Support for Cellular Activity
Sulfora Support is formulated with a unique combination of ingredients designed to support the body’s natural detoxification process by supporting sulforaphane availability.
- Features Brassinase- a specialized broccoli ingredient having active myrosinase and sulforaphane glucosinolate-in combination with sulfoaphane glucosinolate from broccoli seed extract for more reliable sulforaphane conversion*
- Sulforaphane is a potent activator of the body’s own antioxidant and detoxifying enzymes and is responsible for many positive health benefits associated with broccoli consumption*
- Research suggests that sulforaphane may help improve overall redox status to support healthy cell function*
Click Here for more Information and Supplement Facts
Brassinase is a trademark of VDF FutureCeuticals, Inc. Used under license.
Directions: Take 1-2 capsules once daily, or as directed by your healthcare practitioner.
This product is non-GMO, gluten free, and vegetarian.

domain: medical


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The outgoing finance minister Mathias Cormann has defended aged care minister Richard Colbeck, saying he believed Colbeck was a “very effective minister” who should be judged on his overall performance.
Colbeck was unable to immediately provide a Senate committee on Friday with the number of people who have died in the aged care sector during the pandemic, a performance the opposition described as “embarrassing”.
Colbeck later apologised, saying the Morrison government “didn’t get everything right”, but continued to maintain the government had been prepared for what it thought would be the worse-case scenarios.
Cormann said Colbeck was an effective behind-the-scenes operator.
“Richard Colbeck does a very good job, he’s very effective in working with the sector, facing significant challenges – I mean it’s not as straightforward proposition, dealing with the impacts of this sort of pandemic with a highly infectious virus, like this in the context of a very vulnerable sector in our community,” he said from Western Australia.
“I’m sure that he regrets, I’m sure he regrets not having I think that number of these fingertips, but I don’t think that you can judge overall his performance in that portfolio on that basis.
“I see Richard Colbeck, and how he performs, you know, in, in the context of, for example the expenditure review committee for obtaining and securing additional resources for the aged care sector, through our internal processes that is very effective. And I believe that the aged sector knows he can be very effective.”
His comments echo those of the prime minister, who also said on Friday that he had confidence in Colbeck.
A total of 313 aged care residents diagnosed with Covid-19 have died since the beginning of the pandemic. As of Sunday, there were 1,616 active cases of Covid-19 across Victoria’s aged care sector. Eleven of the 17 new deaths announced in Victoria on Sunday were linked to outbreaks in aged care facilities.
The federal government has strongly rejected criticism, including from the aged care royal commission, that it was not prepared for the pandemic’s impact, particularly on the workforce, with centres struggling to find enough staff.
Last week, Scott Morrison responded to criticism of the federal government’s aged care response by pointing the finger at the states – in this case Victoria, where the recent Covid-19 outbreak has ravaged aged care homes – as responsible for public health.
“Well public health, we regulate aged care, but when there is a public health pandemic, then public health, which, whether it gets into aged care, shopping centres, schools or anywhere else, then they are things that are matters for Victoria. So I don’t think that it is as binary as you suggest,” he said.
Cormann also pointed to the Covid situation in Melbourne as exacerbating the issue.
“Clearly, the aged care sector is one of the most vulnerable sectors, when it comes to the impact of this sort of pandemic,” he said.
“And, you know, if you’ve got a jurisdiction like Victoria, where there is a massive outbreak, then you’ve got jurisdiction, and given what’s happening in that jurisdiction, the aged care sector inevitably is particularly exposed.”
Cormann said with the announcement of another $171m in funding for the aged sector, a spend which was overshadowed by Colbeck’s memory lapse, the government had now put “more than a billion dollars in specific support measures in place to support the aged care sector” but added there was “a practical limit to how effective that sadly can be in the context of a virus like this”.
Labor aged care spokeswoman, Julie Collins, said families were waiting for the government to “accept responsibility” and tell people “how they will fix it”.
“The government was warned on nearly all of the issues,” Collins said.
“Can the public now have the confidence they will actually be able to fix this?”
Source: The Guardian


Yesterday Bandai Namco revealed the final character for Soul Calibur VI. The Korean swordsman will return to the series as the game’s final character. Hwang will be available as a DLC character, either as part of the Season Pass 2 or to purchase individually. The introduction of Hwang into Soul Calibur VI marks the return of the character, having not appeared in the series since Soul Calibur III.
Hwang will be available from December 2nd, and the update also brings new customisation options and a new stage. There are also more Tekken themed items, as well as new episodes for Mitsurugi and Nightmare. Hwang’s trailer is available below, as well as a slideshow of screenshots. This has really tempted me to get back into Soul Calibur 6. Are you looking to grab Hwang? Will it get you back into the game, or did you never stop playing? Let us know in the comments below, or tweet us @games_bulletin!


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Encyclopaedia of Brighton
The Encyclopaedia of Brighton, by Timothy Carder, is an invaluable reference book about the history of Brighton.
There are entries on major topics such as the Palace Pier, the Royal Pavilion and the history of the railway – and the book also goes down to such detail that you can also look up your own street!
The Encyclopaedia was first published by East Sussex County Libraries in 1990. The print run has far exceeded expectations.
In 1994, Tim Carder gave permission for an electronic version of the Encyclopaedia to be included in the original ‘My Brighton’ exhibit in Brighton Museum. In 2006, he gave permission for Encyclopaedia entries to be included in the My Brighton and Hove website. The massive task of adding these entries to the site, illustrated with new and old photographs, is being undertaken by a team of volunteers throughout 2007.


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More Senior Living
We have the most fashion-forward styles for Homecoming, Prom and all the events in-between. Terry Costa also has one of the best Bridal Salons in Dallas and features your favorite designers, including Maggie Sottero and Allure Bridal.
We have the most fashion-forward styles for Bridal, Prom, Pageant and all the events in-between.
12817 Preston Rd, Ste 138 Dallas,

domain: design


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Alarm.com ADC-VDBA-WP Product Manuals
Alarm.com ADC-VDBA-WP Overview - Dated February 4, 2021
The Alarm.com ADC-VDBA-WP Overview Guide discusses the ADC-VDBA-WP Mounting Wall Plate Accessory for the Alarm.com ADC-VDB770 Doorbell Camera. This overview explains device purpose, lists its dimensions, and covers installation. This info was referenced February 4, 2021. Learn about the ADC-VDBA-WP.


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Our Misses patterns are drafted for a C cup and our Curvy patterns are drafted for DD. Both are drafted for a height of 5'8" (172 cm).
XS – 3XL
Beginner sewing patterns teach the most foundational sewing techniques. These patterns focus on the basics like sewing and finishing straight and curved seams, hemming, and simple shaping methods such as darts and gathers. In addition, beginner patterns omit closures, making them perfect if you are new to sewing or are looking for a quick and easy make.
Advanced Beginner sewing patterns expand on the skills learned at the beginner level, helping you to build confidence and range as a sewer. You'll find simple knitwear projects, bias tape finishing techniques, and begin to explore closures at this skill level.
Intermediate level sewing patterns focus on more precision sewing. In this skill level, you'll learn specialty closures. Intermediate patterns also introduce the skills needed for simple lingerie and athletic wear projects.
Advanced Intermediate sewing patterns feature specialty skills and focus on exploring niche sewing. You'll find projects like swimwear, lingerie, bias-cut garments, and lined outerwear.
Advanced sewing patterns require great precision and time investment. You'll find tailored pieces in this category with elevated details like bound buttonholes and welt pockets.
Downloadable digital pattern
Our Perry pattern has been discontinued.
Our favorite thing about Perry and Layton is how incredibly versatile they are. In this member exclusive, we offer a new skirt option to create up to six different looks from these patterns. Now you can add a swingy semi-circle skirt to make a breezy, comfortable summer dress. Pair this skirt with the Perry bodice for a look that combines ease and class. Or stitch this skirt with the Layton bodice for the perfect pullover summer frock.


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Join us at The Bruntwood Stage at Homeground for DJ Paulette Presents Together shining like a beacon of hope into our community, social lives and calendar.
Over 50 days every weekday evening, The Bruntwood Stage hosts a stellar array of talent old and new from Greater Manchester’s homegrown, rich, diverse, and musical heritage including the brightest stars from the club, alternative, pop, r n b, soul and electronic arenas.
Due to changes in Homeground’s opening hours, some of the DJs indicated below will now be playing at HOME instead of Homeground.
Here’s this week’s line-up:
Mon 19 Jul 2021 5.30 – 7.30pm
DJ Veba – rescheduled
Playing at HOME Tue 20 Jul 2021 5.00 – 7.00pm
Wed 21 Jul 2021 5.00 – 7.00pm
DJ Swindells – rescheduled
Thu 22 Jul 2021 5.00 – 7.00pm
Fri 23 Jul 2021 5.00 – 7.00pm
About this week’s DJs:
Regular Moustache toting Disco to the house warrior DJ Veba creates a fun vortex wherever she goes. Applying a super glue- like film of chaos and ecstasy on the knees of party revellers all across the Kingdoms. A veritable Jump lead.
Krysko, over the last 20 years, has held some of the most respected and revered residencies within the UK; The Redlight at the original Sankeys Soap, and now The Warehouse Project, where he is the original and longest standing resident.
Through his career to date Krysko has played the world’s most respected nights and festivals throughout the UK, from Sub Club, Fabric, We Love… Space Ibiza, Back to Basics, The Arches, Ministry of Sound, Electric Chair to twice closing the Radio 1 stage at Glastonbury, Parklife, Bestival, Sonar – Barcelona, Secret Solstice – Iceland, Love International, Beatherder, Electric Elephant – Croatia to name but a few… and with regular international dates around Europe and the US including New York, Chicago and Minneapolis.
Deleted: Having shared the stage with a plethora of dance music’s most influential individuals including Derrick Carter, Andrew Weatherall, Mike Banks, Theo Parrish, François Kevorkian, Moodymann, Frankie Knuckles, and Chic’s Nile Rodgers. These aren’t a random selection, just a small selection of people he has performed alongside and of whom he cites these as his musical heroes. This being a testament to his achievements and respect he has gained through his career.
The youngest ever person to play two Live Radio 1 Essential Mixes from 2000 – 2010, and most recently his third in 2013 for the Essential Mix 20th Anniversary where he played back-to-back with Derrick L. Carter.
A regular on the Manchester scene for over a decade, DJ Swindells has gained a loyal following in the rainy city and beyond through his ability to fluently weave together musical treasures from around the globe and across the spectrum. Whether providing the soundtrack to a lazy Sunday brunch or a heaving dancefloor, DJ Swindells combines a selector’s ear with deft technical abilities to engage and excite any crowd.
DJ Riv has graced stages from Manchester Pride to Bluedot to Manchester International Festival bringing a feel good vibe to your Friday night with a little bit of everything from Disco to 90’s R&B and a beautiful smattering of New Soul.
Festival Organiser for Sounds From the Other City and fresh from programming this years Festival Square you can also expect a fair amount of local love from her selections.

domain: artistic


LAGOS (Reuters) – Businessmen in the Nigerian city of Lagos typically broker deals over cognac or champagne. But, on a sunny afternoon in the city’s upmarket Victoria Island business district, a clutch of men celebrated with steaming coffee that cost 35,000 naira ($114) for a three-cup brew.
Jamaica Blue Mountain, the gourmet variety they imbibed, is coveted around the world for its superior quality.
Ibrahim Samande, owner of the Mai Shayi Coffee cafe that sold the drink, knows not everyone can afford the splurge. But he believes cachet and ceremony, and attractive spaces to enjoy a cup, will lure more of Nigeria’s 200 million people to drink coffee.


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Internet memes, rage comics, funny pictures, motivational quotes, trolls.
Submitted By: Batwoman on June 27, 2016
Submitted By: MemeGuru on June 17, 2016
When a celebrity dies, by sudden tragedy or through nature’s course, the public is commonly fascinated and demands to know every last detail. Here we will reveal their final words…
Read on to find out the amazing last words of Frank Sinatra, George Orwell, Ernest Hemingway, Steve Jobs,James Brown, James Dean, John F. Kennedy, John Lenon, Malcolm X, Doe JiMagio, Whitney Houston, Walt Disney, Sigmund Freud, Charlie Chaplin, Michael Jackson, Elvis Presley, Eleanor Roosevelt, Dr Martin Luther King Jr., Heath Ledger, Coco Chanel, Paul Walker, Winston Churchill, Marie Antoinette, Amy Winehouse, Desi Arnaz, Bob Hope, Oscar Wilde, Ryan Dunn, Jane Austen, Alfred Hitchcock, Steve Irwin, Prince, Abbott, Pistol, Emily Dickinson, Putin, Benjamin Franklin, Beethoven, Nostradamus, Harry Houdini.
Rest In Peace!


text:
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text:
Tyrosine kinase-catalyzed protein tyrosine phosphorylation plays an important role in initiating and modulating vascular smooth muscle contraction. The aim of the current study was to examine the effects of isoflurane on sodium orthovanadate (Na3VO4), a potent protein tyrosine phosphatase inhibitor-induced, tyrosine phosphorylation-mediated contraction of rat aortic smooth muscle.
The Na3VO4-induced contraction of rat aortic smooth muscle and tyrosine phosphorylation of proteins including phospholipase Cgamma-1 (PLCgamma-1) and p44/p42 mitogen-activated protein kinase (MAPK) were assessed in the presence of different concentrations of isoflurane, using isometric force measurement and Western blotting methods, respectively.
Na3VO4 (10(-4) m) induced a gradually sustained contraction and significant increase in protein tyrosine phosphorylation of a set of substrates including PLCgamma-1 and p42MAPK, all of which were markedly inhibited by genistein (5 x 10(-5) m), a tyrosine kinase inhibitor. Isoflurane (1.2-3.5%) dose-dependently depressed the Na3VO4-induced contraction (P < 0.05-0.005; n = 8). Isoflurane also attenuated the total density of the Na3VO4-induced, tyrosine-phosphorylated substrate bands and the density of tyrosine-phosphorylated PLCgamma-1 band and p42MAPK band (P < 0.05-0.005; n = 4) in a concentration-dependent manner.
The findings of the current study, that isoflurane dose-dependently inhibits both the Na3VO4-stimulated contraction and tyrosine phosphorylation of a set of proteins including PLCgamma-1 and p42MAPK in rat aortic smooth muscle, suggest that isoflurane depresses protein tyrosine phosphorylation-modulated contraction of vascular smooth muscle, especially that mediated by the tyrosine-phosphorylated PLCgamma-1 and MAPK signaling pathways.
REGULATION of smooth muscle contraction involves complex and overlapping regulatory mechanisms. Smooth muscle contraction is primarily regulated by alterations in intracellular Ca2+concentration ([Ca2+]i). Increases in [Ca2+]i, after the release of Ca2+from the sarcoplasmic reticulum, extracellular Ca2+influx, or both, triggers rapid contraction of vascular smooth muscle through the Ca2+/calmodulin/myosin light chain pathway,1whereas a decrease in [Ca2+]icauses relaxation of smooth muscle. Meanwhile, contraction is maintained and potentiated by Ca2+sensitization of the contractile proteins through several signaling transduction pathways. For example, protein kinase C (PKC) enhances contraction by inhibiting myosin light chain phosphatase, thus reducing dephosphorylation of the myosin light chain.2p44/p42 mitogen-activated protein kinase (p44/p42MAPK), also referred to as extracellular signal–regulated kinase (ERK1/2), potentiates contraction by phosphorylating caldesmon and increasing the binding of actin and myosin.3
In recent decades, a large body of evidence has demonstrated that protein tyrosine phosphorylation by protein tyrosine kinases (PTKs) activates and triggers many intracellular signaling pathways,4including phospholipase Cγ-1 (PLCγ-1)–mediated diacylglycerol/inositol trisphosphate/Ca2+pathway5–8and p44/p42MAPK pathways,9–14resulting in a series of cell events including vascular smooth muscle contraction. Various agonists such as growth factors, angiotensin II, and norepinephrine induce smooth muscle contraction primarily by eliciting PTK-mediated protein tyrosine phosphorylation.5–19Sodium orthovanadate (Na3VO4), a potent protein tyrosine phosphatase inhibitor,20also induces smooth muscle contraction by reducing dephosphorylation of tyrosine-phosphorylated proteins and enhancing the net level of protein tyrosine phosphorylation. Na3VO4has been effectively used to study the protein tyrosine phosphorylation signaling pathway.21,22
Volatile anesthetics have been shown to alter vascular smooth muscle contraction by changing [Ca2+]ivia affection of Ca2+mobilization and/or Ca2+influx23–26and/or by influencing Ca2+sensitization of contractile proteins (such as PKC,27–29Ca2+-calmodulin–dependent protein kinase II,30MAPK,31Rho/Rho-kinase,32and others). Responsiveness of these cellular targets varies depending on the anesthetic agents, stimuli, species, and vascular types. Little information is available regarding whether the alteration in vascular tension by anesthetics is attributable to the direct interruption of these targets, their upstream effectors, or both. Because protein tyrosine phosphorylation plays an important role in initiating and mediating the smooth muscle contraction–associated signaling pathways including PLC pathway and MAPK pathway, it is hypothesized that protein tyrosine phosphorylation by PTKs is a likely target that is interrupted by anesthetics, resulting in alterations of the activity of its downstream effectors, such as PLCγ and p44/p42MAPK. The current study is designed to examine the effects of isoflurane on the protein tyrosine phosphorylation–mediated vascular smooth muscle contraction elicited with Na3VO4, using isometric force measurement and detection of protein tyrosine phosphorylation, especially tyrosine phosphorylation of PLCγ-1 and p44/p42MAPK.
Materials and Methods
Isometric Force Measurement
With the approval of the Animal Care and Use Committee of Wakayama Medical University (Wakayama City, Japan), male Wistar rats (weight, 250–350 g) were anesthetized with halothane and were exsanguinated by bleeding from the common carotid artery. Descending thoracic aortas were carefully removed and rapidly immersed in ice-cold Krebs bicarbonate solution (pH 7.35–7.45) of the following composition: 118.2 mm NaCl, 4.6 mm KCl, 2.5 mm CaCl2, 1.2 mm KH2PO4, 1.2 mm MgSO4, 24.8 mm NaHCO3, and 10.0 mm dextrose. The adherent connective tissue was cleaned, and rings (3–4 mm in length) were obtained. After removal of the endothelium by gently rubbing the intimal surface with a stainless steel needle, the rings were mounted between wire hooks in a 10-ml organ bath containing Krebs bicarbonate solution warmed at 37°C and aerated continuously with 95% O2–5% CO2. The lower wire hook was fixed within the organ bath, and the upper hook was fixed to an isometric force transducer (Nihondenki-sanei Co., Tokyo, Japan). Isometric force development was recorded by using a force recorder.
Isoflurane was introduced into the gas mixture using an agent-specific vaporizer (Penlon Limited, Abingdon, Oxon, United Kingdom). The concentration of the resulting gas mixture was monitored and adjusted using an Atom 303 anesthetic agent monitor (Atom, Tokyo, Japan). The concentrations of isoflurane in Krebs bicarbonate solution were measured by gas chromatography (Shimazu Seisakasho, Kyoto, Japan) and were determined to be 0.19 ± 0.01 mm (0.9% or 0.6 minimum alveolar concentration [MAC]), 0.39 ± 0.01 mm (1.8% or 1.3 MAC), and 0.56 ± 0.03 mm (2.6% or 1.9 MAC) at isoflurane concentrations of 1.2% (1 MAC), 2.3% (2 MAC), and 3.5% (3 MAC) in the gas mixture.
Each aortic ring was allowed to equilibrate for 60 min (with the organ bath solution changed every 20 min) at a resting tension of 3 g. Then rings were exposed to Krebs bicarbonate solution containing KCl (3 × 10−2m) to assess their overall contractile responsiveness. Rings that did not develop at least 2 g contractile active force were discarded. Removal of the endothelium was confirmed by the lack of relaxation to acetylcholine (10−5m) in rings precontracted with phenylephrine (3 × 10−7m).
In a first series of experiments, the time course of the Na3VO4(10−4m)–induced contraction was measured. Genistein (5 × 10−5m), a tyrosine kinase inhibitor, was applied either 15 min before Na3VO4treatment or after attainment of a sustained Na3VO4-induced contraction to assess the Na3VO4-induced, tyrosine phosphorylation–mediated contraction. To examine the effects of isoflurane on the Na3VO4-induced contraction, rings were exposed to 1.2, 2.3, or 3.5% isoflurane for 15 min before treatment with Na3VO4or after sustained Na3VO4-stimulated contraction had been achieved. The inhibitory effect of isoflurane on contraction was expressed as a percentage of the control.
Detection of Protein Kinase Phosphorylation
Rat descending thoracic aortas (approximately 3.5 cm in length) were excised. The vessels were carefully freed of all extraneous structures and opened longitudinally, and the endothelium was removed gently with a stainless needle. The prepared aortas were bathed in organ chambers with oxygenated Krebs bicarbonate solution and were equilibrated for 60 min before exposure to the agents. One aorta was used for each sample.
The time course of the Na3VO4-induced protein tyrosine phosphorylation was determined in the first experiment. Aortas were incubated in 10−4m Na3VO4for 0, 2, 5, 10, 20, or 30 min and were then rapidly frozen with dry ice. The detection results showed that tyrosine phosphorylation of the substrates (including PLCγ-1 and p42MAPK) reached a peak level 20 min after Na3VO4application. In the following testing experiments, aortas were pretreated with genistein (5 × 10−5m), 0, 1.2, 2.3, or 3.5% isoflurane for 15 min and were quickly frozen 20 min after Na3VO4(10−4m) application.
Frozen aortas were cut into small pieces and were homogenized in ice-cold lysis buffer (50 mm HEPES, pΗ 7.5, 1% Triton X-100, 50 mm NaCl, 50 mm sodium fluoride, 5 mm EDTA, 10 mm sodium pyrophosphate, 1 mm phenylmethanesulfonyl fluoride, 1 mm Na3VO4, 10 μg/ml leupeptin, and 20 μg/ml aprotinin).15Homogenates were centrifuged at 15,000g for 15 min at 4°C. The supernatant was collected, and protein concentration was determined using bicinchoninic acid method.33Solutions of the protein extracts were prepared by mixing them with an equal volume of 2× sample buffer (125 mm Tris, pH 6.8, 10% glycerol, 2% β-mercaptoethanol, and 0.08% bromophenol blue). The diluted samples then were heated in boiling water for 3 min and were stored at −80°C.
In each experiment, samples were used at equivalent total protein content. Proteins were separated by 7.5% sodium-dodecyl-sulfate polyacrylamide gel electrophoresis and electroblotted onto nitrocellulose membranes. The electroblotted membranes were incubated in blocking buffer (containing 20 mm Tris, pH 7.5, 150 mm NaCl, 3% bovine serum albumin, and 0.02% sodium azide) overnight at 4°C, and were then incubated with a phospho-tyrosine monoclonal antibody (p-Tyr-100, 1:2,000), phospho-PLCγ-1 (Tyr783, 1:1,000), or phospho-ERK (p44/p42MAPK) antibody (Tyr204, 1:1,000) for 4 h, followed by incubation with horseradish peroxidase–conjugated antibody (1:2,000) for 1.5 h. The densities of the immunoreactive bands were detected using chemiluminescence (Amersham Pharmacia Biotech, Piscataway, NJ) and were assessed with image analysis software (NIH Image 1.62, Bethesda, MD). The band densities of tyrosine kinase–phosphorylated substrates, PLCγ-1, and MAPK were expressed relative to the basal control level (referred to as 1).
Na3VO4and genistein were purchased from Sigma-Aldrich Fine Chemicals (St. Louis, MO). Isoflurane was obtained from Dainabot Company Limited (Osaka, Japan). Phospho-tyrosine monoclonal antibody (p-Tyr-100) and phospho-PLCγ-1 antibody (Tyr783) were bought from Cell Signaling Technology Inc. (Beverly, MA). Phospho-ERK (Tyr204) antibody and the secondary antibody labeled with horseradish peroxidase were supplied by Santa Cruz Biotechnology, Inc. (Santa Cruz, CA). Other reagents for the tension measurement and Western blotting were all of analytical grade.
The results are presented as mean ± SD. The sample size (n values) represents the number of aortic rings (for tension measurement) or of aortas (for Western blotting), which equals to the number of rats used. Two-factorial analysis of variance was used to compare the effects of the different isoflurane concentrations on the Na3VO4-induced contraction, the band densities of tyrosine-phosphorylated substrates, PLCγ-1, and p44/p42MAPK, using the software program StatView (SAS Institute Inc., Cary, NC). P values less than 0.05 were considered statistically significant.
Na3VO4-induced Contraction and Protein Tyrosine Phosphorylation
Sodium orthovanadate (10−4m) induced a sustained contraction of rat aortic endothelium-denuded rings, reaching a maximal level comparable to that of the 3 × 10−2m KCl–induced contraction, 12.8 ± 3.2 min after its application, and maintained a stable contraction for at least 2 h (fig. 1A). Genistein (5 × 10−5m) reversibly and significantly depressed the Na3VO4-induced contraction when applied 15 min before (fig. 1B) or after (fig. 1C) treatment with Na3VO4.
A set of tyrosine-phosphorylated protein bands between 42 and 190 kd molecular weight, especially bands of 42, 45, 71, 88, 116, and 155 kd, were detected after stimulation with Na3VO4. The band density reached peak level 20 min after Na3VO4application and was significantly reduced by genistein (5 × 10−5m) (fig. 2A), which was consistent with the time course of the Na3VO4-induced vascular contraction.
The bands of molecular weight of 155 kd and 44/42 kd were identified as PLCγ-1 (fig. 2B) and p44/p42MAPK (fig. 2C) by phospho-PLCγ-1 antibody (Tyr783) and phospho-ERK (Tyr204) antibody, respectively. The densities of the phospho-PLCγ-1 and phospho-p42MAPK bands reached peak level 20 min after treatment with Na3VO4and were markedly attenuated by genistein (5 × 10−5m), with a similar time course to that of the tyrosine-phosphorylated substrates, but no significant change in the density of p44MAPK band was observed with Na3VO4treatment (figs. 2B–D).
Effects of Isoflurane on Na3VO4-induced Contraction and Protein Tyrosine Phosphorylation
Isoflurane concentration-dependently and reversibly depressed the Na3VO4(10−4m)–induced contraction of rat aortic smooth muscle rings, with reductions of 18.3 ± 4.8% (P < 0.05), 71.4 ± 5.5% (P < 0.005), and 84.8 ± 3.6% (P < 0.005) in response to 1.2, 2.3, and 3.5% isoflurane gas mixture, respectively. The tension recovered to control level after termination of isoflurane exposure (n = 8; figs. 3A–C).
Isoflurane decreased the band density of the Na3VO4(10−4m)–elicited tyrosine phosphorylation of total substrates in a concentration-related manner, with total decreases of 29.1 ± 5.4% (P < 0.05), 63.3 ± 4.9% (P < 0.005), and 73.1 ± 3.7% (P < 0.005) in response to 1.2, 2.3, and 3.5% isoflurane gas mixture, respectively (n = 4; fig. 4A).
The densities of tyrosine-phosphorylated PLCγ-1 band and p42MAPK band were also attenuated dose-dependently by isoflurane, with reductions of 31.3 ± 4.4% (P < 0.05), 60.4 ± 6.0% (P < 0.005), and 84.3 ± 4.9% (P < 0.005) for PLCγ-1 band density (n = 4; fig. 4B) and of 17.5 ± 2.9% (P > 0.05), 50.4 ± 7.3% (P < 0.005), and 72.9 ± 8.6% (P < 0.005) for p42MAPK band density in response to 1.2, 2.3, and 3.5% isoflurane gas mixture, respectively. However, isoflurane up to 3.5% did not affect the density of tyrosine-phosphorylated p44MAPK band (n = 4; figs. 4C and D).
Protein Tyrosine Kinase–catalyzed, Tyrosine Phosphorylation–mediated Contraction of Vascular Smooth Muscle
Protein tyrosine kinases are important elements of cellular signal transduction pathways, and three general subclasses have now been found: (1) the membrane receptor PTKs, which are regulated by extracellular ligands, such as epidermal growth factor and platelet-derived growth factor5,6,9,34; (2) cytosolic nonreceptor PTKs, such as the proto-oncogene products Abl and Fes, which seem to be located in the cytosol, and relatively little is known about their effects; and (3) the membrane-associated nonreceptor PTKs, such as p60c-src , which are lapidated and bound to the cytoplasmic face of the plasma membrane. They are activated by various agonists such as angiotensin II,7,8,10,14,15,17,35endothelin,35,36arginine-vasopressin,17,18and noradrenaline11,17through G protein–coupled receptors.
Protein tyrosine phosphorylation by PTKs modulates many signaling transduction pathways, and is thought to represent the beginning of a cascade of events. The amount or extent of protein tyrosine phosphorylation is regulated not only by the rate of phosphorylation catalyzed by PTKs, but also by the rate of protein tyrosine dephosphorylation catalyzed by protein tyrosine phosphatases. Therefore, both agonist-induced increases in protein tyrosine phosphorylation and protein tyrosine phosphatase inhibitor–produced decreases in protein tyrosine dephosphorylation are able to augment the net level of tyrosine kinase–phosphorylated proteins, resulting in contraction of vascular smooth muscle cells. The reduction of protein tyrosine phosphorylation by tyrosine kinase inhibitors, such as genistein, tyrphostins, and geldanomycin, depresses signal transduction and causes a relaxation of vascular smooth muscle cells.16,37,38In the current study, rat aortic smooth muscle was stimulated by the potent protein tyrosine phosphatase inhibitor Na3VO4to induce constant tyrosine phosphorylation of many proteins and sustained vascular contraction, which was significantly attenuated in the presence of genistein (figs. 1 and 2).
The activation of PTKs by agonists or depression of tyrosine phosphatase by tyrosine phosphatase inhibitors, such as Na3VO4, enhances tyrosine phosphorylation of a set of substrates ranging from 40 to 205 kd,4,15,17,11,21varied depending on the stimuli, species, and vascular types. These target substrates are involved in various responses, such as cell growth, division, proliferation, and smooth muscle cell contraction, most of which have not yet been identified. In the current study, Na3VO4increased protein tyrosine phosphorylation of a set of substrates, especially of those with molecular weights of 42, 71, 88, 116, 155, and 190 kd, which was significantly decreased in the presence of genistein (fig. 2A). In regard to the mechanisms of smooth muscle contraction, PLCγ-15–8and p44/p42MAPKs (or ERK1/2)9–14are phosphorylated by tyrosine kinases, consequently activating the diacylglycerol/inositol trisphosphate/Ca2+pathway and p44/p42MAPK pathway, finally increasing [Ca2+]iand potentiating myofilament Ca2+sensitivity. The increase in tyrosine phosphorylation of PLCγ-1 and p42MAPK by Na3VO4was confirmed with specific antibodies in our experiment (figs. 2B and C). However, the alteration of tyrosine-phosphorylated p44MAPK by Na3VO4was not detected in this study, which is consistent with the findings that p42MAPK but not p44MAPK was involved in the serotonin-induced tyrosine phosphorylation.12However, angiotensin II–induced and endothelin-induced tyrosine phosphorylation resulted in the expression of both p44MAPK and p42MAPK.35It may depend on the agonists used, the experimental condition, or vascular beds. The Na3VO4-induced vascular contraction in our study likely involves in the mechanisms of PTK-phosphorylated PLCγ-1–mediated and p42MAPK-mediated increase in [Ca2+]iand Ca2+sensitivity.
The tyrosine phosphorylation of PLCγ-1 activates inositol trisphosphate/Ca2+/myosin light chain kinase/myosin light chain 20 signaling pathway and diacylglycerol/PKC signaling pathway, resulting in vascular contraction. Both tyrosine and threonine phosphorylation of p44/p42MAPK by PTKs and MAPK kinase, respectively, phosphorylate caldesmon and separate its binding to actin, potentiating smooth muscle contraction (fig. 5).
Effects of Anesthetics on Protein Tyrosine Phosphorylation of Vascular Smooth Muscle
The important finding in the current study is that isoflurane inhibited both the Na3VO4-stimulated contraction and tyrosine phosphorylation of a set of proteins including PLCγ-1 and p42MAPK in a concentration-dependent manner, although the extent of the inhibitory effect on these parameters was not the same. This inhibition on tyrosine phosphorylation of a set of proteins and PLCγ-1 was significant even at a low concentration of isoflurane (1 MAC). It seems that the inhibitory potential on PLCγ-1 was greater than that on p42MAPK.
Many studies have been conducted on the effects and the mechanisms of anesthetics on vascular smooth muscle contraction, most of which have focused on Ca2+mobilization and Ca2+sensitivity. In cultured fetal rat aortic smooth muscle cells, 2% isoflurane and 2% halothane attenuated the serotonin-induced Ca2+mobilization (or [Ca2+]i) by approximately 26% and 43%, respectively.25Akata et al. 26reported that 3% isoflurane inhibited both the norepinephrine-induced contraction and increase in [Ca2+]iby approximately 30% but only attenuated the 40 mm KCl–induced contraction by approximately 30%, without significant effect on [Ca2+]iin isolated mesenteric resistance arteries. In another study, Akata et al. 23also demonstrated that the inhibition of sevoflurane on the norepinephrine- and KCl-induced contraction of isolated mesenteric resistance arteries occurred mainly by depression of the voltage-gated Ca2+influx and by inhibiting the myofilament Ca2+sensitivity. We demonstrated that sevoflurane concentration-dependently suppressed both the GTPγS-stimulated contraction and membrane translocation of Rho and Rho-kinase in aortic smooth muscle, thus suppressing the Rho/Rho-kinase signaling pathway–mediated Ca2+sensitization.31We also reported that sevoflurane depressed both the angiotensin II–induced contraction and the phosphorylation of Ca2+-dependent PKCα, without affecting [Ca2+]iin rat aortic smooth muscle, suggesting that sevoflurane inhibited the angiotensin II–induced, Ca2+-dependent PKCα-mediated vascular contraction.29However, other investigators showed that isoflurane decreased the angiotensin II–induced mobilization of intracellular Ca2+, Ca2+release from internal stores, and Ca2+influx through nifedipine-insensitive Ca2+channels.24Based on these findings, volatile anesthetics seem to have the ability to alter vascular smooth muscle contraction by interrupting different signaling pathways: Ca2+-mediated signaling pathway, Ca2+sensitization mechanisms, or other mechanisms, depending on the anesthetic agents, agonists, species, and vascular types.
Protein tyrosine kinases are the upstream effectors of some signaling pathways, and protein tyrosine phosphorylation is an important mechanism to activate and initiate a cascade of cellular responses. The current study showed that isoflurane inhibited the Na3VO4-induced contraction and protein tyrosine phosphorylation of many enzymes, including PLCγ-1 and p42MAPK, even at clinically relevant concentration. We speculate that the isoflurane-evoked decrease in [Ca2+]iand the depression on Ca2+sensitivity, as suggested by other studies23–29is modulated, at least in part, by inhibiting the protein tyrosine phosphorylation of PLCγ-1, p42MAPK.
In summary, the current study demonstrates for the first time that isoflurane concentration-dependently inhibits both the Na3VO4-stimulated contraction and tyrosine phosphorylation of a set of proteins including PLCγ-1 and p42MAPK in rat aortic smooth muscle. This suggests that isoflurane depresses protein tyrosine phosphorylation–modulated contraction, especially tyrosine-phosphorylated PLCγ-1 and p42MAPK signaling pathway–mediated contraction of vascular smooth muscle.
The authors thank Shunji Itoh, M.D. (Assistant Professor, First Department of Pathology, Wakayama Medical University, Wakayama City, Japan), and Akira Ooshima, M.D., Ph.D. (Professor and Chairman of the First Department of Pathology, Wakayama Medical University), for their guidance and help in the Western blotting experiment.

domain: chemistry


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Moonta was the home to the richest cooper mine in Australia during the end of the 19th century. You can find out what happens in the mine at Wheal Hughes Mine. You can also learn about the town's history at the Moonta Heritage Site, which has a guided walk around the area. There is a museum on the site and an old miners cottage nearby. You can also visit the old school, which is now a folk museum.
Moonta is a historically significant town of South Australia with its well-maintained historic buildings and the the ruins of the old copper works.
Considered by some as 'Australia's Little Cornwall' a title perhaps taken from the fact that the first miners to the area were Cornishmen, a fact reinforced by the bi-annual Cornish Festival held in May. The Cornishmen employed century old mining techniques to extract copper ore from the mines. It is reputed that 'The Moonta Company' was the first mining company to shell out over a Million Pounds in dividends.
There are several cafes and a few pub style restaurants in town where you can eat out, as well as a small selection of accommodation.
Destinations within Yorke Peninsula
|Other Yorke Peninsula Destinations|

domain: history


text: Moody provides a visual tagging interface for music played on iTunes. A 4 x 4 grid of colored squares provides the clickable UI for describing the mood of music tracks along the vertical axis as calm to intense, and along the horizontal axis as sad to happy. Great concept and quite easy to get after a few tries. With tracks tagged by mood, you can later play them back by selecting clicking the listen tab, and selecting as few or many moods as you would like, and finally click play. Moody works by simply adding tags to the tracks' comments field and creates playlists when you select a new set of moods to play.

domain: entertainment


text:
Fear of Passing Wind Hypnosis Script
Passing (or breaking) wind is a normal bodily function that most of us learn to control, however for someone with a fear of doing this in public the control factor is not enough and it can create profound feelings of anxiety just at the thought of going out or meeting up with people.Read More
Those suffering from this phobia may find themselves needing to know where the nearest public convenience is 'just in case' and quite often, their life seems to be centred on this problem.
If your client has a fear of passing wind, this script can help them to overcome the negative feelings associated with any past memories so that they can accept themselves as normal, functioning human beings.
The script also helps with comments about how to create amnesia for the session to enhance the strength of the suggestions and increase its effectiveness.
Download the Fear of Passing Wind Script:
Option 1: Download Single Script
Option 2: All-Script Access Membership
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Discover related scripts and resources:

domain: psychology


Geneva Classics always brings out some impressive vintage cars and this year was no exception. At the forefront of these was a Hai 450 SS from the Monteverdi museum. It ranks among the very few Swiss supercars ever made.
Another highlight of the show was a display that included the entire Slavic Collection. This had some rare Ferraris, but many of the heavy hitters were recreations built on donor Ferrari chassis.
Other cars which stood out were Jean-Bugatti’s personal Type 49, a Bentley Cresta, David Brown’s first car, the DB1, and a quintet of swiss Bugattis. All these can be found in our feature gallery by Julien Giambagli.


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text:
'For Richer, for Poorer': Top 10 Family Articles of 2008
- 2008 27 Dec
What challenges did 2008 bring to family life? This should come as no surprise: economic concerns dominated daily routines. Whatever your background, chances are your household sought ways to trim spending and safeguard your financial futures. But money wasn’t the only thing on your minds. Seeking out -- and sticking with -- God-honoring marriages remains a priority among Crosswalk readers. Here are the ten most-read Family articles of '08:
1. Homemade Gift Ideas Under $10 by Mary Hunt
Abstract: Christmas ’08 was the year of the budget! Here are numerous gift ideas that not only cost very little, but have that personal touch that makes gifts extra special to those on the receiving end no matter the occasion.
Key Quote: “With a chance to stay away from the crowded malls you might just find yourself with extra holiday spirit — and cash, too — to take you into the New Year.”
2. Painless Ways to Save Money by Tawra Kellam
Abstract: Economic woes hit us where it hurts – our pocketbooks. Thankfully, Tawra Kellam, author of Not Just Beans: 50 Years of Frugal Family Favorites, offers surprisingly painless tips that add up to some serious yearly savings.
Key Quote: “By themselves, these efforts may seem small -- but they add up to over $7,000.”
3. The Differences between Men and Women’s Brains by Whitney Hopler
Abstract: Once you understand how differently God has designed male and female brains, you can learn how to use those differences well in your marriage.
Key Quote: “While men’s conversations tend to focus on facts, women’s conversations tend to emphasize the feelings behind the facts. Men solve problems best by thinking about one issue at a time, usually on their own. But women generally need to talk through problems with someone else to process their thoughts.”
4. 8 Characteristics of Mr. or Mrs. Right by Julia Ferwerda
Abstract: Determining the person God wants you to spend the rest of your life with is a critical decision, one that requires putting aside personal desires in order to consider this: What is God trying to tell me about this relationship?
Key Quote: “I believe a great ‘barometer’ of a person’s walk with God is whether he/she tries to entice you into sexual sin or not. If he/she truly loves God and wants to be obediently set apart for Him, there won’t be any excuses, playing with fire, or compromises. This person will honor God above his/her own selfish desires, and because of that he/she will honor and love you enough to protect your body until marriage as well.”
Reader Comment: “I think the article is a blessing, all the above are A MUST and it ends beautifully, that as a reader you are challenged especially if you [are] to be a better person. If I may, also I think that Mr. or Ms. Right's other relationships should be in consideration. In my opinion, I would think of individuals who are good in some given relationship(s) to be good in another. Therefore, if my relationship with my parents, peers, co-workers and church family is dysfunctional, it will take more prayer and fasting for me to be Mr. Right." ~ Kamya
5. The 10 Commandments of Marriage by Bayless Conley
Abstract: I want to point us to principles God has given us in a place you might not think was intended for marriage. That place is the Ten Commandments, found in Exodus 20...
Key Quote: “Good marriages don’t just happen. It is not just because you married the right person and got lucky. Good marriages are built on more than passion. They are built on principle.”
Reader Comment: “Wow, it is amazing to read something you really need to read and it couldn't have come at a better time, our 2nd yr anniversary of marriage. We have a wonderful marriage and this article can only strengthen it. Thank God for the insight he has given you. ~ Gary (glove472000)”
6. Beware of Becoming This Type of Man by Dr. John Barnett
Abstract: God's Word goes so far as to even identify what type of person we should avoid, stay away from, never consider as a viable marriage partner, and certainly not become.
Key Quote: “Beware of becoming an Ungodly Person. Proverbs 16:27: An ungodly man digs up evil, And it is on his lips like a burning fire. This fellow rarely show hunger for God's Word, or concern for the Spirit of God, or passion for fellowship or worship of God. They have no song from the Lord on their heart, anger and self-centeredness are their habits.”
Reader Comment: “*Gulp* I found these warnings to be equally applicable to women/wives. Thank you for putting it on the line succinctly and boldly for ALL of us who desire to walk in a godly manner, pleasing to the Lord.” ~ Heartie
7. The Warning Signs of Infidelity by Nancy C. Anderson Abstract: How do you know if your marriage is in danger of falling victim to infidelity? Author Nancy C. Anderson gives some often missed warning signs that may help protect your marriage.
Key Quote: “When you're guarding your marriage, you're not guarding just your spouse, but guarding yourself too. I rationalized my way into a boatload of trouble because I thought, The rules don't apply to me. I've been to Bible College, I'm smart, I have self-control, and I can stop before it gets too far. All lies!”
8. Is there More to Sex than Pleasure? by Mindy Meier Abstract: Do you need to rethink your view of sex? My hope is that you’ll catch a glimpse of God’s wonderful view of sex and that it will capture your heart and transform the way you live.
Key Quote: “Sex pulls us out of our self-absorption to unite us with another human being. Jesus gives an indication of this unity when he says, ‘The two will become one flesh’ (Mark 10:8). Marriage is a laboratory to learn how to love.”
Reader Comment: “This is such a refreshing article. Thank you for communicating that sex for the Christian couple is more than pleasure. In our society, we have become such ‘lovers of pleasure’ that we forget to honor God in everything. This article teaches us to honor God with our sexuality. I pray we all change our hearts back to what God intended.” ~ odieham
9. Marrying Your ‘Soul Mate’: Does Such a Person Exist? By Edward M. Tauber & Jim Smoke
Abstract: Never fully defined in any literature, the term “soul mate” is used by people as if we all clearly understood what is meant...
Key Quote: “If you think there is only one person out there who is the right one for you, you are vulnerable to marry when you think you have found that person. There is much evidence that there are likely many people in the world who would make an acceptable mate for you. The risk of thinking otherwise is that when you believe you have found ‘the one,’ you abandon all sensibility and are driven to marry that person…”
Reader Comment: “... I believe God gave me the one for me! I think the danger isn't in believ[ing] that only one exists for you, but in how we go about that, what we sacrifice to find that, and if we let it jeopardize our relationship with Christ in order to fulfill that desire.” ~ cinderella092003
10. The Lost Girls by A.J. Kiesling
Abstract: At the singles functions I’ve attended, I can’t help but notice how many attractive women mill around, trying to be sociable, likable, and noticed. So with so many single men out there, why are so many Christian women growing old alone?
Key Quote: “[Jillian] Straus concludes that it isn’t anyone’s imagination; it is harder to find lasting love in today’s culture, and she identifies seven ‘evil influences’ that have changed us from the inside out: 1) a self-serving ‘what’s-in-it-for-me?’ culture, 2) a multiple choice culture, 3) the effect of divorce, 4) the feminism fallout, 5) a ‘why suffer?’ mentality, 6) the celebrity standard, and 7) delayed marriage.”
Reader Comment: “In response to the Lost Girls article I would first like to say thank you for bringing this sensitive subject to the forefront. Unfortunately I cannot agree with your opinion regarding on-line dating. It is unfortunate that we as Christian women have been programmed to look for Prince Charming to ride up on a white stallion, sweep us off our feet and ride off into the sunset. The reality is people meet each other in various avenues of life. I used to think online dating was ‘unromantic’ and unsafe, but, after being single for most of my adult life I realized that I was limiting myself by a fantasy that is not biblical. Once I became open and receptive to meet ‘the one’ through any avenue that God chooses, I met and married my husband...” ~ adivarev

domain: literature


text:
+i took my obsessions to a higher level and learned the art of stalking people...tee hee hee
+i found a buttload of new bands
+i went to sheeeit load of concerts
+i was in a music video..that did nothing..damn nhoi!
+i went thru a spiral of depression
+i learned to be more outgoing
+i was promised something by a certain DOUCHEBAG for new years eve...that didnt happen! ass...
+i turned 18
2. be more outgoing
3. fall in love?
4. get my license
5. get a job
heh..we'll see how those go...tee hee!!!!!!


text:
You can all most of the information you need to plan your trip to Silkeborg Søhøjlandet here. Learn about when it is the best time a year to visit, find information about how to get to and from Silkeborg and where you can find inspiration for activities when you have arrived.
Find information about train- and bus connections to Silkeborg. If you are travelling by car, you can find a map of best parking spots.
Find brochures, maps or have a chat with our skilled co-workers about what to see and do while in Silkeborg

domain: geography


text:
After careful consideration of the public health situation in the country (and in particular, in Dublin), the IRAAL 2020 Organising Committee have agreed that the Annual Conference cannot be held in November 2020 as planned. As there is not yet a viable online format to comfortably produce a 1.5 days conference, putting this conference on as a webinar does not seem possible at the moment. The conference will be, therefore, postponed until Spring 2021.
IRAAL’s AGM will take place online in November. Further details will follow.


text:
During a recent email exchange with my publicist, we were discussing fun facts about the author—the author being me. While ruminating on my travel experiences, my mind wandered to the pets I’ve had in various countries throughout the years, and some were not your normal ones. read more…
When I stopped posting to my blog in early 2016, it was never my intention to be gone this long. I even hate to admit how long it has been, but not every year turns out the way you had planned. But I’m back and thrilled to be posting again. So from the three of us, Pat, Darcy, and Bullet, we wish you, our readers and blog subscribers, the best in 2017.
I call 2016 my building block year. The long tradition of naming my years originates with dear family friends Bob and Ginger, who asked back in 1988 for a yearly newsletter rather than a Christmas card. The titles for these newsletters were a summation or a highlight of that particular year. For example: Traipsing Across the Globe, New Kid in Town, Knee-Deep in Gadgets . . . you get the picture.
Sadly, Ginger passed away some years ago, but I continued my tradition with Bob until he passed on as well. This past Thanksgiving I found myself thinking of Bob and Ginger and our annual newsletter. In 2016 I built a foundation for the future of the Darcy McClain and Bullet Thriller Series. As the release of Genocide (book three) approached, I knew I needed to implement a sound marketing plan, but what I needed even more was a good publicist, someone who could assume that responsibility, allowing me to return to what I love best—writing.
Last year started as a footrace and the marathon continued into the summer—designing a new website, brainstorming a comprehensive marketing plan, reviewing multiple edits of Genocide, and revising large sections of Clonx (book four), not to mention working on long, detailed summaries for two new books in the thriller series. When creativity strikes, you need to respond and record.
In early August 2016 the unthinkable occurred: our giant schnauzer Kai died of lymphosarcoma at the young age of seven. The pain of his loss overshadowed my desire to press on with the series. I knew I would at some point, but I needed time to grieve and to deal with his sudden passing, and under this shadow the rest of 2016 just slipped away.
The only consolation during this sorrowful period came on October 26, when a friend and fellow giant schnauzer owner paid us a visit and brought along Tonka, the rescue she was fostering. We weren’t ready for another giant, but his owner had died and Tonka needed a forever home. After a five-minute meet and greet, we decided his new home should be with us.
His name certainly suited him. Tonka, in the language of the Lakota people (of the Sioux tribes), means great or large, but we soon grew tired of people calling him Tonka Toy and renamed him in the spirit of the two giants (Shotz and Kai) who had gone before, and whose personalities had shaped the giant in my thriller series. First in fiction and now in real life, Bullet had been rescued.
By late September, Shotz was healing well from her dual surgeries, but she still had one more medical surprise for us. In early October 2001, we drove up to our vacation home in Taos, New Mexico, to check on the house and to winterize it.
On a prior trip we had ordered bar stools for the kitchen, and they were ready to be picked up in Santa Fe. We would’ve loved to have taken Shotz with us, but there was not enough room in the hatch area of my SUV for both her and the stools. In preparation for the drive down, we crated her. And since she was a master escape artist, we secured the crate door with a clasp at the top and one at the bottom, the kind you see on the end of a dog leash. We would’ve preferred her to have the run of the house, but the last time we left her uncrated she destroyed most of the blinds, along with half of the window screens. They weren’t even repairable as she had chewed the metal frames into numerous bite-size pieces and left the mesh in piles throughout the house.
Twenty minutes after we arrived in Santa Fe, we had loaded the stools and were on our way back to Taos. The moment we opened the door into the house I knew something wasn’t right. Even when crated, she would greet us with a bark, but the house lay silent. I rushed into the master bedroom and stopped in midstride, surprised by the scene before me.
She had rocked her crate onto its side and had wedged one corner of it into the drywall. The bedspread had been yanked off the bed, and she had pulled about a quarter of it into her crate and shredded it, the down feathers everywhere. But neither the drywall damage nor the torn bedspread concerned me as much as the sight of her mangled wire crate. We had to cut the door open with wire cutters to free her. I felt terrible that she was so stressed about being left behind that she had caused this kind of destruction. I vowed then to never crate her again.
Extricated, Shotz appeared physically drained and immediately settled onto the bed for a nap while I began cleaning up. Halfway through vacuuming pile after pile of down feathers, I stopped to run my hand over the rug, puzzled by the sound of gravel being sucked into the vacuum cleaner. Then my heart sank when I saw something white lying on the carpet.
I hoped I was wrong, but when I gently pried open Shotz’s mouth I was upset to see the truth. In her attempt to escape from her crate she had chipped several teeth and fractured her canines. How badly, I wasn’t sure, except for one of her upper cuspids, which she had fractured at a sharp angle. The crack ran from the tip of the tooth, and from what I could see, up and under the gum line.
When we returned home to Texas, our vet recommended against extracting any of Shotz’s canines. The roots, he informed us, are usually twice as deep as the tooth is long, and extracting these teeth can cause serious nerve damage or even loss of eyesight. I took his advice after I did some research of my own on the potential side effects of tooth extractions in dogs.
The ultimate decision was an easy one. I would never do anything to jeopardize her vision, so with a referral from our vet I made an appointment to see an oral surgeon in Dallas to get her opinion and to hear her recommendations.
The dental vet informed me that Shotz had chipped at least eight teeth in addition to having minor fractures to two of her canines. These didn’t need any work. However, the third canine, the one I already knew was badly fractured, would require either extraction or a root canal. It had cracked about a sixteenth of an inch into the gum line and could become abscessed at some point. So I opted for the root canal.
After she recovered from her oral surgery, I informed Shotz that she had maxed out her credit card and therefore couldn’t pay for another medical procedure. She groaned, but fortunately she had no additional mishaps and went on to live a long, healthy life.
We said our final goodbyes to Shotz on June 16, 2009, one of the most heartbreaking days of my life. It took until now, 2014, to find the emotional strength to write about her.


text:
The national referral hospital is not the only institution that has a problem with a dwindling supply of blood. According to the Director of Health Services, Marvin Manzanero it is a situation that is facing all healthcare facilities. He told us that there is a year-round blood drive for Belizeans to donate blood.
Marvin Manzanero Director of Health Services: “We noticed the low blood supply towards the end of last year and the blood bank has always been pushing for blood supplies to be routinely kept and so we had sent out a memo even before the Christmas and the New Years Holidays were upon us to tell regional Hospital to exercise caution in terms of how they were going to go about their blood supply and that means that you are probably going to have less elective surgeries if you don’t have adequate blood supply. I know the Western Regional Hospital has made an appeal earlier this year and I believe a Blood Bank in Belize on January 19th is having a blood drive and so that is part of the ongoing process. Unfortunately we are one of the countries that have one of the lowest voluntary blood donations happening, one of the lower ratios in the region if not the lowest ratio in the region so people would only routinely donate blood once they know a family members is going to be having surgery so it is not that you have routine blood donors going in to keep the demand of blood products in the country and then when you have road traffic accident and gun violence those are the ones that are most going to be using blood supply so any blood that you may have in stock can be depleted rather quickly . The call is always going to be there, we are trying to do blood drives not only in Belize City but at the regional Hospitals and we are going to try to see if we can expand the hours that people can donate and maybe have that on weekends because sometimes people will say well I work 8 to 5 to I can’t donate then. We will look at different incentives to try to bring people on board. That’s part of the plans that we have for this year.”


HOUMA - As threats of West Nile continue to make front-page news in Louisiana, overgrown weeds and muddy brown water collect in a collapsed public swimming pool near Legion Park Middle School, even as children play each day on a new playground and tennis courts.
But while they may be unsightly, local officials insist the pool, along with three or four smaller ones nearby that were shut down nearly 20 years ago, are not mosquito breeding grounds.
"We have it under control," said Lisa Thiel of Mosquito Control Inc., the company contracted to eliminate mosquitoes in Terrebonne Parish.
After receiving complaints from neighborhood residents, Thiel said the company last week stocked the pools' water, more than a foot deep in shallow areas, with mosquito-eating minnows.
When the fish were deposited in the pools, Thiel said they immediately began eating mosquito larvae, ensuring the pesky insects won't ever be able to hatch.
As schools and Terrebonne Parish officials begin to increase mosquito sprayings around public buildings and areas where children congregate, other measures are being used to eliminate mosquitoes where they breed.
Fathead and killfish minnows are a natural way to greatly reduce the number of mosquitoes in fields and neighborhoods near stagnant pools of water.
Mosquito officials consider the fish a useful alternative because they don't require any of the pesticides used in sprays and fogs and they're fairly cheap.
In bulk, 5,000 fish only cost 4 cents apiece.
Experts say minnows, also called mosquitofish, are the most versatile fish for stocking in any pond or lake in the United States because they only need shallow water for protection.
Minnows are the most widely used fish in the world for mosquito control, known to consume 230 larvae or pupa in one hour. They're adaptable to most water conditions, bear live young that begin feeding immediately, and their gestation period is short, so they're able to produce several generations per season.
For mosquito control, between 300 and 500 minnows are needed per acre.
When it comes to West Nile, stagnant water is dangerous because mosquito eggs are laid on water that has collected in any structure that holds water after a rain. The eggs hatch into legless larvae that feed on fine debris and tiny organisms in the water.
Larvae can develop in watering troughs, small ponds, irrigation ditches, rain barrels, manure lagoons, ruts where farm equipment frequently travels and other areas where water is allowed to accumulate.
The close proximity of livestock, birds and other animals to mosquito-breeding habitats increases the risk for the transmission of disease.
At the Legion Park pools, Recreation District 11 board member Paul Arceneaux said weeds and tall grass surrounding the fenced-in lot also have been recently sprayed to prevent mosquitoes from hatching.
Arceneaux said the pools have been mostly emptied so that there's just enough water for the minnows to survive.
"Our main concern right now is getting rid of the liability these pools are causing us," said Arceneaux, who hopes to negotiate an agreement with parish government to eventually fill the pools with rocks and cover them with topsoil.
The public pools were shut down about 17 years ago, around the same time the pool at Dumas Auditorium was closed.
Arceneaux said the pools were closed for political reasons and have not been touched at all since.
"It was the previous administration, and it was before our recreation league was formed about six years ago," he said.
But before the pools are closed for good, Arceneaux said measures will continue to be taken to prevent mosquitoes from breeding, with more fish and sprayings added during warmer months.
Kimberly Krupa is a staff writer for The Courier. She may be reached at 850-1148 or by e-mail at firstname.lastname@example.org.


Sram Force 22 Hydraulic Disc Brakes Front & Rear Set
RRP $699.94Save 29%
Sram Force 22 HRD Disc Brake STI'S - 11 Speed. Complete set.
Force 22 HRD shift-brake levers combine all the great performance of mechanical 11-speed with the performance of a hydraulic disc braking system. With Sram's trademark Reach Adjust as well as improved ergonomics for better finger wrap, Sram's HRD controls are the touch point for better braking. Sram's hydraulic brakes deliver more braking force with less hand effort and better modulation.
- Flat mount Calipers
- Front Hose Length: 820mm
- Rear Hose Lenght: 1890mm
- Revised ergonomics for better finger wrap and a revised shifter paddle for improved finger clearance
- Individual Reach Adjust
- Carbon brake levers/ aluminum shift levers
- Low hand force required
- Fully sealed system for no contamination
- Easy bleed access
- Use this 11-speed shifter for both SRAM Road 2x drivetrains
- Optimized stopping power and modulation for cyclocross
- 18mm front/ 18mm rear pistons
- Specific caliper and piston ratio
- 160 or 140 Centerline rotors sold separately
- Forged aluminum disc caliper with steel-backed organic pads and stainless hardware
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Free shipping on this item to United States
Steve PFantastic Sram product. Powerful braking with 160mm rotors front and rear. Gear shifting is extremely precise if a little clunky compared to other manufacturers. Decent weight saving and great in all weathers and conditions. Well recommended


text:
Social expectations surrounding Thanksgiving are so high that sometimes we forget about those of us who are alone on this High Holy of Food Holidays.
Grumpy Cat's new movie is terrible, and so are we.
No matter what people tell you, it's just not a thing.
Even as Buffalo's snowstorm goes viral, climate change denial keeps going strong.
Media doesn't work the way it used to.
The media response to Taylor Lianne Chandler's revelation that she was born intersex illustrates our failure to understand trans issues.

domain: sociology


text:
Arguments and discussions
What is a balanced argument?
A balanced argument is a discussion or piece of non-fiction writing that considers both sides of an issue.
These key stage 1 and key stage 2 English teaching resources will support children in writing a balanced argument. They’ll help children to explore different points of view and find reasons for and against an issue to present both sides of the argument.
You’ll find worksheets to help children identify the features of a balanced argument, planning sheets to help them structure a balanced argument and templates for their final written argument. Topics include school uniform, a longer school day and whether we should have a car-free world. You’ll also find a resource pack of discussion texts.
You may also like our persuasive writing resources.


text:
Show and Tell Feb. 23
This week’s show and tell we’ll be looking at Lua and the LÖVE game engine. I will show a small puzzle game made with LÖVE (pun intended).
The zoom meeting will be HERE at 1pm on Tuesday.
Or you can join with meeting ID: 829 7708 3019 and password: 982778.


The HSE has launched a campaign encouraging women to avoid alcohol entirely during pregnancy.
Professor Frank Murray, Chair of Alcohol Health Alliance Ireland, told The Last Word that there is "no safe limit" for the consumption of alcohol during pregnancy, and that expectant mothers or those who are thinking of getting pregnant should avoid it completely.
The warning comes as a study of 187 countries estimated that Ireland has the third-highest rate of Foetal Alcohol Spectrum Disorders, which can severely impact a baby's development.
Irish women have also previously been ranked among the heaviest binge drinkers in the world.
Foetal Alcohol Spectrum Disorders can cause various problems such as developmental and physical delay, intellectual disability and inattentiveness in later life.
We were also joined on the programme by Noelle Younkin, who is a member of ENDpae, a support group for people affected by Foetal Alcohol Spectrum Disorders and their families.
Noelle adopted two sons, both of whom have Foetal Alcohol Spectrum Disorder.
She says that pregnant women can often give in to pressure from family and friends to have a drink, and that they need support and encouragement to avoid doing so.
Listen to the interview in full by pressing the play button on this page.


text:
Many future space missions including Large UV/Optical/Infrared Surveyor and Laser Interferometer Space Antenna require metering structures of exceptional geometric stability in order to meet their science goals. Thermal expansion and contraction of these structures is typically a primary concern. The application of a known high-stability bonding method, hydroxide catalysis bonding, to a new structural material, ALLVAR Alloy 30, with the uniquely useful property among metals of a negative coefficient of thermal expansion is studied. We report on measurements of the shear breaking strength of Allvar mated with fused silica (glass), grade 5 Ti-6Al-4V (Ti64), and aluminum 6061-T6 (aluminum). Measured shear breaking strengths ranged from 3 to 16 MPa with a mean of ∼7.5 MPa. Initial series of tests indicated no significant correlation between bonding strength and surface roughness over the range of surface roughness tested.
A microwave phase-control scheme is proposed and experimentally demonstrated. Two lasers are combined in an optical fiber coupler to generate a beat signal. The beat frequency is tuned by controlling the frequency of one laser. Using the phase shift of the beat waves with different frequencies during the propagation in an optical fiber, the phase of the radio-frequency (RF) signal generated by a photodetector (PD) can be controlled. Using the phase shift during the propagation of beat waves in an optical fiber with different beat frequencies, the phase of the RF signal generated by a PD connected to the fiber can be controlled. A tunable phase shift ranging from 0 deg to 1400 deg is obtained for frequencies from 6 to 10 GHz. This scheme offers the advantages of fast tuning and precise phase control of an RF signal.
Optical systems made for space-based interferometric missions like LISA or SIM must be made of materials that can endure significant accelerations and temperature fluctuations while staying dimensionally stable. Temperature-induced effects can be reduced with thermal shielding techniques and estimated using the thermal expansion coefficient. However, the stability is often limited by virtually unquantified material internal relaxation processes. In this paper we describe the experimental layout and present the status of our experiments to measure the dimensional stability of Zerodur and Hexoloy SA® silicon carbide using hydroxide-bonding and discuss its feasibility for the LISA mission.
The Laser Interferometer Space Antenna (LISA) is a joint NASA/ESA space mission aimed to detect gravitational waves in the 3×10-5 to 1Hz frequency range. Expected sources for LISA include super massive black hole mergers (SMBH), galactic neutron star and white dwarf binaries, and extreme mass ratio inspirals (EMRI). The three LISA spacecraft will travel in a heliocentric orbit trailing or leading earth by about 20°. The distance between the spacecraft will be about 5 million km or 16s light travel time. Laser interferometry will measure the distance with pm/√Hz accuracy. This report focuses on the technology for LISA interferometry.
In the advancing field of gravitational wave interferometry, the desire for greater sensitivity leads to higher laser powers to reduce shot noise. Current detectors such as LIGO and GEO 600 operate with continuous wave lasers at 10-15 W powers, however future versions will operate at 200 W. One of the major challenges of higher power operation is the creation of thermal lenses in optical components, caused by from the absorption of laser light, yielding optical path deformation and concomitant beam aberrations. This effect is especially problematic in transmissive optical components even at very low levels of absorbed power. In environments that restrict the ability to move optical components (such as gravitational wave detectors), this effect can be used for beneficial purposes, specifically for providing adjustable beam-shaping. The method employs an additional laser having a wavelength strongly absorbed by the substrate and can create an aberration-free parabolic lens can be created provided that the heating beam mode is
substantially larger than the transmitted beam mode. The resulting focal length varies inversely with the heating laser power. This idea forms the basis for an adaptive optical telescope. We present experimental and theoretical results on a laser adaptive mode-matching system that uses an argon laser absorbed in a color glass filter. We characterize the dynamic focal range of the lens and measure the resulting aberrations in the transmitted Nd:YAG beam. Our results are in good agreement with a theoretical model incorporating the temperature distribution of the lens and the relevant thermo-optic parameters.


My amp just died and I need something to plug my guitar into.
I have and old CASIO CT-700 tone bank keyboard witch has 4 ports:
- MIDI in
- MIDI out
Is it possible?
Music: Practice & Theory Stack Exchange is a question and answer site for musicians, students, and enthusiasts. It only takes a minute to sign up.Sign up to join this community
No, you cannot plug your guitar in this particular keyboard. The Phones jack is a stereo output for headphones, the sustain connector is for a pedal/controller and the midi connectors are for midi control signals to and from an audio interface of some description.
It is possible to connect guitars to some keyboards, as I have utilized this functionality in the past, but they tend to be very expensive keyboards and you're not really meant to do it.
You could however invest in an audio interface and plug your guitar into your PC, then use a guitar effects/amp simulation or modeling program. That or invest in a new amplifier.