Advantages of Solar Energy Make Them Yours
Advantages of Solar Energy: Make Them Yours
by Jim Martin
Find out what the solar energy advantages are and how they can be transformed into your personal money savings.
Solar energy, as the name suggests, is derived from the sun (and not, the moon). The benefits of solar energy to mankind are manifold. Until recently, solar energy could be made use of only during the day. However, with the advent of new technologies, solar energy can now be tapped and used even during the night. Here, we will be looking at some of the major benefits of solar power.
Solar energy is, by nature, environmentally viable and non-polluting, and often considered to be the best among such energy sources. In particular, the eco-friendly nature of this source is expected to come to the fore in the future. The sun provides heat and light during the day; in addition, electricity can also be made available during the night, provided the solar power system is grid-tied, or has a battery-back. There are other benefits of solar power systems as well.
If some amounts of electricity generated in this process remain unutilized, it can be made saleable by moving them to the utility or the grid. No upfront payment is required for this transfer of surplus electric power, and some money can be made out of it. Running costs are extremely low on solar energy, helping the consumers drastically cut down on their expenses on electricity. With no movable parts, the solar panel itself does not have any other additional costs too. Thus, there are three major benefits of using solar energy for generating electricity: a) reducing the electric bills of consumers by large amounts, b) helping users earn some cash by selling surplus amounts of electricity, and c) the extremely eco-friendly nature of solar energy.
Solar power systems help in keeping the environmental balance of the world intact. Traditional fossil fuel based energy sources generally release gases like carbon dioxide (CO2), sulfur dioxide (SO2), methane and nitrous oxide (NO) into the air. These gases, termed as greenhouse gases, contribute to global warming. Solar energy avoids the usage and release of these gases. Hence, it remains eco-friendly, and does not bring with it the risks of global warming. The harmful smog or acid rain, generated by the fossil fuel sources, is also not an issue when solar energy is used.
Solar power is advantageous, since the supply of raw material (i.e. sunlight) is abundant and renewable, and the solar energy stations can be set up independently as well. Other accessories of the system are also freely available. Solar power stations function noiselessly too - much to the convenience of users. These facilities, hence, make solar energy extremely popular for various purposes. The solar energy systems can be installed at all parts of the world as well. Solar power packages often come complete with battery banks, converters and control panels. Controllers are used to convert modules of power from solar panels to usage of battery. These systems, with their tough trailers, are often used by geologists, when they move in lands, hitherto unexplored, in search of oil and minerals.
In the present day world, the internal combustion engines, and in turn, vehicles that use those engines are facing a crisis. This is chiefly due to the amount of fossil fuel going down, and the rapid hike in oil prices. In this scenario, it is indeed advantageous to make use of solar power. Experiments with solar power based vehicles are on, and the markets have already seen the presence of hybrid cars. According to experts, fossil fuel driven cars would be effectively replaced by entirely replaced by solar power driven vehicles, that too within the foreseeable future. The latter would also prevent the release of the polluting carbon monoxide gas. That would definitely ensure a cleaner, healthier atmosphere.
Over time, the cost of using photovoltaic cells is going down. Hence, the process of harnessing solar energy is becoming cheaper, so that it is gradually being used even in such areas where conventional energy sources had held sway over the past years. According to experts, vehicles that use internal combustion are on their way out, with solar-powered vehicles taking their place. This would definitely lift the purity of the air surrounding us. Thus, solar energy holds out significant advantages over other conventional energy sources. Indeed, it is on its way to become one of the chief sources of power worldwide.
Before actually setting up solar power systems, a training manual needs to be consulted regarding the proper manner of installing such systems. The place to acquire batteries, the place where you can get these batteries for free, and the ideal place to set up such a system are all discussed in the manual. All possible safety related queries as well as the wiring systems need to be explained in detail. Once users have these data, they can easily set up effective solar energy systems in their homes.
About the Author:
Jim Martin is a researcher, inventor, home energy consultant and author of the best-selling e-book, "Earth 4 Electricity- Renewable Energy Made Easy". To Learn More about Jim Martin's Unique Step By Step Solar and Wind Power System Visit: Earth 4 Electricity. For further information visit: Solar Energy Advantages and Disadvantages .
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Let The Beat Drop: Dancehall Censorship In Jamaica (Council of Hemispheric Affairs)
Boasting its fiftieth year of independence, the Greater Antillean isle of Jamaica touts a large and progressive musical catalog that makes the industry one of the country’s most internationally known exports. Indigenous to Jamaica, reggae is a calming music that inspires tranquility and feelings of adoration. In contrast, dancehall music is more upbeat and often a more raunchy relative of reggae. Lyrically, reggae is closer to Standard English, making it more internationally accessible then patois, or Jamaican Creole, often used in dancehall. Dancehall is a popular music style amongst Caribbean youth, but rarely receives respect from other demographics due to its lyrical content. Since the early 1990s, dancehall has been lambasted for homophobic content that inherently advocates violence against homosexuals within Jamaica.
INTERVIEW: Real McKoy Speaks On His “Bigger Brother” Busy Signal (Boomshots.com)
We all appreciate good music. No doubt we’re familiar with the artists, but rarely do we get up close and personal with the individuals behind the scenes—the producers and engineers sweating to bring us the music we crave. I had an opportunity recently to catch up with a brilliant young producer and artist by the name of Gilmore Walters, more popularly known as Real McKoy. We spoke about his record label/studio Trainline Records, his latest productions, as well as his friendship with Busy Signal. Interview After The Jump.
Nicco ready for face-off (The Jamaica Observer)
DJ Nicco is in Chicago to represent Jamaica at the world finals of the Red Bull Thre3Style competition which was sheduled to start yesterday until September 29.
“I am excited to go out and represent my country. In Jamaica, our party culture is extremely diverse and incorporates a little of everything and I am excited to see how other top DJs get their crowds going,” Nicco says, as he eyes the title of ‘World’s Best Party Rocker’.
British Reggae Singer Lady Lex Sizzles On “Just To Be With You” (Urban Islandz)
British reggae singer Lady Lex highlights the story of a couple falling hopelessly in love and trying to maintain a long distance relationship, on her latest single Just to Be with You.
The engaging track with emotion and sugar coated vocal muscles, is featured on the Amore rhythm from Donsome Records.
“The song describes how the woman desperately wants to be with her man, even if it’s only for a couple of seconds,” Lady Lex explained in a release to the media.
Tiana hits MTV Africa’s Top 10 charts with ‘Dem a Bawl’ (The Examiner)
The ‘Princess of Dancehall,’ Tiana continues to accumulate success on her path towards international superstardom as she’s earned recognition in the Motherland for her musical exploits.
Having infiltrated the airwaves this past summer with a number of hits including, Watch Dem a Watch Me, One Stuck Whine and Don’t Stop, Tiana has copped a top 10 slot on MTV Base Africa Top 10 Dancehall chart with another smash, Dem a Bawl. This marks the first time that Tiana has earned a top 10 spot on any MTV music chart as Dem a Bawl place 10th on MTV Africa’s chart this week.
Busy Signal to be released from prison on November 22 (Joy Online)
Management of Jamaican dancehall artiste, Glendale Goshia Gordon popularly known as Busy Signal has disclosed that the artiste will be released from prison on November 21.
Busy Signal was arrested at the Norman Manley International Airport in Jamaica in May due to an extradition warrant from the US.
Busy Signal broke jail some ten years ago on charges of cocaine trafficking but was grabbed and detained in London earlier this year and subsequently repatriated to the United States for trial.


OUTREACH AND PRODUCTION INTERN
Maia joined the Pulitzer Center on Crisis Reporting in January 2010. Prior to this, she interned at Voice of America radio's French-to-Africa service, broadcast in Central and West Africa. Maia has also worked as a photo editor for Discovery Communications, and has interned at the Agence France Presse, as well as for Amnesty International's Africa Advocacy Department, and the Centre for the Study of Terrorism and Political Violence in St Andrews, where her focus was Southern Iraq. Maia holds a M.A in Arabic and Middle East Studies from the University of St Andrews in Scotland. She also spent a year in Cairo studying Arabic, Gender Issues, political Islamic thought and Egyptology. While in Cairo, she did field work to study the impact of various development programs geared toward the empowerment of women in a poor Cairene urban setting, whether through micro-credit schemes, or politically connecting women to state institutions, with the goal to allow them to actively participate in changing their social and political landscape. She is now focusing on Haiti, and women and children in crisis.


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Technology & Combat Characteristics
Slash ZAKU Warrior is the close combat configuration of the ZGMF-1000 ZAKU Warrior achieved through the use of the back-mounted EX-K Slash Wizard. In addition to the standard armaments of the ZAKU Warrior, the Slash ZAKU Warior is armed with two MMI-M826 "Hydra" Gatling beam cannons as well as a MA-MR Falx G7 beam axe, which is possibly the strongest melee weapon available to the ZAKU Warrior. The Slash ZAKU Warrior is one of the lightest configuration of the ZAKU Warrior and this allows it to stay mobile during close combat.
- Hand Grenade
- Four hand grenades are stored on the suit's side skirt armor. Several different types can be carried, including fragmentation, high-explosive, and smoke grenades.
- Shoulder Shield
- A distinctive shield mounted on the left shoulder, leaving both hands free to hold weapons. The shield is capable of independent movement, has an anti-beam coating on its surface and three spikes for use in melee combat. Additionally, the shield's back has hardpoints for mounting two spare magazines for the beam assault rifle. It also stores the beam tomahawk, which slides out of a slot near the top of the shield when deployed, grip first.
- MA-M8 Beam Tomahawk
- An axe-shaped weapon that emits a curved beam blade, it is the ZAKU Warrior's primary close combat weapon and can also be thrown.
- MMI-M633 Beam Assault Rifle
- The primary ranged weaponry of the ZAKU series, this beam firearm's design emphasizes destructive power and rapid-fire capabilities. Its accuracy is lowered somewhat as a result, but the scattering of its beam shots allows for simultaneous attack of multiple targets. Unlike most beam rifles, it does not draw power from the mobile suit's battery. Instead, the rifle is powered by the energy stored in a replaceable drum-type magazine. When not in use, this weapon could be stored on the back waist armor.
- MA-MR Falx G7 Beam Axe
- The primary close combat weapon of the Slash ZAKU Warrior, the MA-MR Falx G7 beam axe is like a pole-arm version of the beam tomahawk. The beam axe has a greater reach than the beam tomahawk and may even be greater than most beam sabers. The beam axe has two beam blades at the top and a scythe attached to the bottom. When not in use, the beam axe's handle can retract and the weapon is stored on the rear waist armor
- MMI-M826 "Hydra" Gatling Beam Cannon
- Located on the back-mounted Slash Wizard are two MMI-M826 "Hydra" Gatling beam cannons. The Gatling beam cannons posses a very high rate of fire in exchange for weaker beams, and are mainly used for suppressive fire and for intercepting attacks. Unlike the beam rifle of the ZAKU Phantom, the Gatling beam cannons are directly powered by the suit's battery.
Special Equipment & Features
- EX-K Slash Wizard
The ZAKU Warrior was one of the machines in the "New Millennium Series" that was developed to cope with the technological and numerical restrictions placed on the various superpowers as part of the Junius Treaty signed after the first war. When the Second Alliance-PLANT War broke out between ZAFT and the EA, the ZAKU Warrior and its higher performance sibling, the ZGMF-1001 ZAKU Phantom, were used alongside the older models in the war. Due to the ability to utilize the "Wizard System", which is a series of interchangeable armament packs, the ZAKU Warrior can adapt to different combat situations. One such pack is the Slash Wizard equipped by the Slash ZAKU Warrior. While not the most common configuration of the ZAKU Warrior, the Slash ZAKU Warrior participated in many theaters of war such as the PLANTS, the moon, and the Orb Union.
|Mobile Suit Gundam SEED C.E. 73: STARGAZER Mechanics|
GAT-01A2R 105 Slaughter Dagger | GAT-X103AP Verde Buster Gundam | GAT-X105E+AQM/E-X09S Strike Noir Gundam | GAT-X1022 Blu Duel Gundam | GFAS-X1 Destroy Gundam
Linear Gun Tank
|Aircraft / Spacecraft|
|Transporter / Supply Ship|
|Cruiser / Mother Ship|
TFA-4DE GAZuOOT | TMF/A-802 BuCUE | TMF/A-802W2 Kerberos BuCUE Hound | ZGMF-1000/A1 Gunner ZAKU Warrior | ZGMF-1000/K Slash ZAKU Warrior | ZGMF-1000/M Blaze ZAKU Warrior | ZGMF-1017 GINN
GSX-401FW Stargazer Gundam | UT-1D Civilian Astray DSSD Custom
ZGMF-1017 GINN Insurgent Type

domain: design


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Over the last few months I've been developing LISP code to automate some assembly drawings. The process is carried out completely without user intervention. And that is the key as we now want to roll it out to some sales people who have little if any training in the use of AutoCAD.
Once the drawing is completed in model space we have four different layout tabs, each with a different paper size (A-D) and a different viewport scale. It works really great except that most of the time the users are requesting 11 x 17 size drawings and when the assembly get large, the way it fits in the paper space has to be adjusted.
My goal is to find some method of using the center of the three orthograohic views of the assembly (front, top and side views). I pretty sure I can calculate the point of the center of a rectangle that just enclose these three views and then zoom from there, but the trick would be to get the viewport scale set to something that wouldn't be whacko like 1-7/64" = 1'-0". The goal is to stay with 1:8, 1:12, 1:16, 1:20, etc...
Any pointers or suggestions would be appreciated.
Well, you can go inside the mspace vport and do a zoom extent.
Then grab the viewsize:
(setq vwz (getvar"viewsize"))
Goto Pspace and grab the pspace vport object and save it to variable " en " and then grab the following info:
(setq ed(entget en))
(setq vwh(cdr(assoc 40 ed))) ; vw height
(setq vww(cdr(assoc 41 ed))); vw width
Next, calculate the current value of the vport scale:
(setq vps(/ (/ vwh vwz) (/ vwh vww)))
Finally find the closes zoom scale factor that's greater than the current vps and use that.
Access a broad range of knowledge to help get the most out of your products and services.


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Distressed Twill Boyfriend Pants
What's the perfect color for Spring and Summer? A light and faded sage, of course! These twill distressed pants are so comfortable and easy, you'll want a pair for every day. Nice weight cotton you don't have to worry about show-through. With an elastic drawstring waist, you can adjust for your perfect fit. Raw hems can be worn straight or rolled. To complete these perfect spring bottoms, we point out side hip and back pockets!


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Lunch today is provided by Etienne who says:
Hello, here is my contribution to the daily lunch blogging being held at cynical-c.
It is a beef pot roast seasoned with red wine, worcestershire and frozen strips of bacon. Because I had a lot of soy milk stashed that was soon going to be past due I made a soy milk gravy with the cooking juices.
This is a small portion to insure good taste before freezing as is customary for lunches in my house.
Thanks Etienne. If anybody would like to share your lunch with the rest of us hungry Cynics, send me an email with a photo and description.

domain: food


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Cannabis isn’t recreationally legal in Australia, but there’s news that Greens might legalize it before 2023.
Weed aside, what other drugs are Australians using, and how easy is it to access these substances? The Australian Drug Trends 2022 report found that drug users in the country prefer three commonly used drugs, but the frequency of using them is changing yearly.
This report has been conducted annually since 2003 and provides interesting insight regarding the drug trends and varying popularity of substances as time goes on. The group surveyed was between the ages of 20-31.
Let’s see which drugs Australia preferred in 2022 and if there have been changes in drug usage over the years.
The drug that came in third was cocaine, clocking in at a record-breaking 79% of participants saying they had used cocaine in the past six months. Individuals reported that they usually paid around $350 per gram, but they’re also aware that what they’re buying might not be the purest stuff.
And then, we have cannabis. 79% of participants reported that they had used cannabis in the last 6 months. Interestingly, the country’s cannabis use seemed to decrease from last year by 5% (84%).
Individuals said they were paying anywhere from $300 for an ounce of high-quality weed and around $250 for an ounce of mediocre weed. Not only did national cannabis use remain somewhat consistent, but individuals reported it is one of the easiest drugs to access.
It looks like Australians are favoring ecstasy. What’s interesting is how the 2022 report highlighted that 88% of participants reported using the drug in the last six months, but overall ecstasy use dropped 7% since 2021 (95%).
Funny enough, even though 88% of participants used ecstasy this year, this was the smallest percentage of ecstasy users since these reports first started in 2003.
So, regardless of how many people are using it, reports show that ecstasy use in Australia is declining. Might cannabis take the #1 spot next year? We’ll have to wait and see.

domain: news


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Anna Faris earned $14 Million – $14 000 000 this year which works out to be ~$38356,16 per day; ~$1166666,67 per month; ~$269230,77 per week; ~$1598,17 per hour; or ~$26,64 per minute; ~$0,44 per second.
Full Name: Anna Kay Faris
Date of Birth, Age: November 29, 1976
Birth Place: Baltimore, Maryland, U.S.
Source of Income: Acting, Singing, Comedy
Wikipedia Page: Here
Source of Wealth Acting, Singing, Comedy
Birth Place Baltimore, Maryland, U.S.
Height 5′ 5″ (1.65 m)
Marital Status Married Chris Pratt (m. 2009), Ben Indra (m. 2004–2008)
Full Name Anna Kay Faris
Date of Birth November 29, 1976
Occupation Actress, Comedian, Singer

domain: celebrity


January 19th, 2022
RLI Managing Director Kathrin Goldammer is a speaker at an online panel of the Fraunhofer ENIQ on the future of hydrogen technology.
The digital discussion format looks at and evaluates the role of hydrogen in the context of decarbonization and energy system transformation. Kathrin is one of four experts who look at the topic from different angles.
The discussion is preceded by a launch of the Fraunhofer “Cluster of Excellence ‘Integrated Energy Systems'” (CINES). Fraunhofer CINES has developed a storytelling format that examines the question of the future of hydrogen in a CO2-neutral energy system with the help of various energy system models.
The discussion is part of a two-day-event. On the second days – January 20th – the Fraunhofer scientists will give deeper insights on their energy system models.


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My next door neighbor Parker Jax is not my type. He’s covered in tats, rides a motorcycle, and his parties keep me up all night. The fact he’s sexy as sin doesn’t change the fact we are oil and water.
I’m a quiet artist. He’s a rowdy marine. I’ve got a broken heart. I’m convinced he doesn’t have a heart at all.
Thankfully, my bad-boy neighbor is on leave from the Marines for only thirty days. But then the jerk has to go and show me that he has a soft side beneath all those hard muscles. He actually leaves his own party to help me, and he didn’t even have to.
Fantastic. Now I owe him.
I’m not worried, though. What are the chances he’ll need me to do anything before the month is up?
But when a woman shows up with a kid at her side, knocking on Parker’s door, it turns out those chances are pretty good...
Hottie next door!
Her Marine Next Door by Aliyah Burke.....what a yummy neighbors turned lovers story! Skylar is a single, artist who enjoys the eye candy next door. Parker is a Marine, home, doing physical therapy so he can rejoin his team. They both enjoy the views, but never talk more than to complain about the parties Parker has or for him to ask to borrow something. Everything changes when a one night stand shows up on Parker’s porch with a kid. His hare-brained idea throws Skylar and Parker together and what unfolds is a story of trust, love and steamy scenes. In the beginning I felt there wasn’t a good flow to some of the story but overall it was a page-turner that once again kept me up way too late! Since I got this ARC from the publisher for my review, I’m looking forward to more from this publisher as well as the author. This was my first Aliyah Burke book and I’m excited to read her others!

domain: literature


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Solomon Warriors retain the Telekom S-League title for the third consecutive season after winning by default over FC Guadalcanal today to clinch their sixth domestic title as the TSL 2019/2020 season champions.
Warriors finish on top of the standings with 41 points ahead of arch-rivals Henderson Eels who once again claim the second spot with 38 points.
Solomon Warriors coach Henry Fa’arodo Junior is thrilled for being a champion in his first season as a coach after a decorated career being a player.
“I am excited about the next level which is the O-League,” he said.
“Being with the boys and crown champions is a big step forward for me as well.
“I was once a football player and coming into coaching as a career now.
“To take the boys into the O-League is a big achievement for me and the boys”.
As the Solomon Islands winners, Warriors will be traveling to New Caledonia for the Group C of the 2020 OFC Champions League group stage.
“I think for us it’s a good group looking at the teams that we are going to compete with. I hope we can do well and advance into the next stage,” Fa’arodo added.
Warriors are drawn in Group C alongside AS Magenta (New Caledonia), AS Tiare Tahiti (Tahiti) and qualifying stage runner-up.
Henderson Eels will be competing in an all Melanesian group which consists of Malampa Revivors (Vanuatu), Lae City FC (PNG) and Lautoka FC (Fiji).
The OFC Champions League group stage next month in New Caledonia and Vanuatu.


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The average literate Nigerian reading this would have read or come across snippets of history in their lifetime – from Nigeria’s amalgamation and the First World War in 1914, to our independence in 1960 and the launch of the first human spaceflight in 1961. You would probably have heard of several inventions that took place during that period and would have been left asking the question:‘What were our ancestors doing when all this was happening?’
But really, where were they? In the time interval spanning from 1500 till 1800, before colonial era, when other countries and empires of the world were busy advancing their technologies, sailing round the world and discovering new elements, what exactly were our ancestors doing? What parts of the world did they sail to? What discoveries did they make and document beyond herbal medicine and cultural values? How come when the Portuguese and the British came, our ancestors were almost powerless to resist them? How come the mirror (a piece of glass) became the value of exchange for the life of a Nigerian in the name of slave trade? Why were our ancestors so crude? Did they arrive on earth really late?
I really don’t have any answers to these questions and I’m not sure anyone does. But more important to me is the question our grandchildren will ask of this generation in another fifty years; when they look back and realize, that we were actually alive during the births of the GSM era, the Smartphone era and the Social Networking era. They will be shocked that even though, unlike the ancestors before us, we were aware of and used these technologies, we contributed little or nothing to their creation. They will be stumped to realize that despite being one of the largest consumers of telecommunications technology and services, we could not even attempt to invent any for ourselves. They will also be surprised beyond belief that 129 years after the first automobile was produced, Nigeria was yet to start manufacturing its cars. In fact, they will laugh to stupor when they realize that we were still importing crude oil 50 years after we had discovered it.
This is what I’m driving at. It is time we shifted our orientation from that of consumers of technology to creators of technology. And our current startups don’t qualify in this regard – successful startups truly owned (and funded by Nigerians) are as hard to find as Wizkid in Ojuelegba. Much of the technology we use today, have come from and is being controlled by nationals of other continents, including the servers hosting the websites where some of you spend the useful part of your lives.
Like it or not, we’re repeating the pattern of our ancestors and it’s only a matter of time before our progenies start asking us the same question: What were you doing when the world was moving forward? The thought of that alone bothers me. And it should bother you too. Because if this doesn’t bother you then I don’t know what will.
Photo Credit: Dreamstime | Denise P. Lett

domain: history


For some reason, whenever I open up reaper, my internet stops working. When I close reaper it starts working again. I have no idea what's wrong. Done all the "normal" update, roll back, update drivers, rebooted, shut off power saving mode on the WiFi and ethernet connection.
I'm still connected to the network, but it says no internet. If I run network diagnostics while reaper is running, it says I need can't connect to DHCP server and DNS server. Ten seconds after I close reaper it works as normal.
Anyone have any idea what's wrong?


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Chunky Knit Pot Holder
Regular price $8.95
Shipping calculated at checkout.
The softness and texture of this 8" square cotton crocheted pot holder is a must for any kitchen. The chunky hand crocheted pot holder/trivet has a small loop on one corner.
Available in 2 different colors, Ivory and Sage, each sold separately.


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Critique the Community
Submit Your Best Photos Of Plants
Submit your best foliage photo for a chance to win a free Fstoppers tutorial
Submission Deadline: Thu, 05 Dec 19 04:45:00 +0000
This contest has ended.
Voting is closed.
Congratulations to the winners!
The depth of field seems to shallow for what I think is trying to be done here. The blur on the front left of the image is super distracting and keeps drawing my eye to it. Perhaps a deeper depth of field or blur the foreground too. I would consider, may not make it better, dodging/burning a little to darken the white on the top right 1/3 and pull a little shadow out of the dark berries. That may or may not make it a better image.
Thank you for your thoughtful critique.

domain: hobby


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Doxorubicin-induced Automaticity in Cultured Chick · PDF fileDoxorubicin-induced Automaticity...
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Transcript of Doxorubicin-induced Automaticity in Cultured Chick · PDF fileDoxorubicin-induced Automaticity...
[CANCER RESEARCH 50, 4209-4215, July 15, 1990]
Doxorubicin-induced Automaticity in Cultured Chick Heart Cell Aggregates1
Joan C. Mitrius2 and Stephen M. Vogel3
Department of Pharmacology, University of Illinois College of Medicine, Chicago, Illinois 60612
The use of doxorubicin, a clinically important antitumor agent, isassociated with toxic cardiac side effects, including arrhythmias and, onrare occasions, sudden death. We have used aggregates of cultured chickembryonic heart cells, a preparation free of neuronal and vascular elements, to investigate the direct effects of doxorubicin on automaticity.Under control conditions, normally quiescent aggregates of ventricularorigin could be induced to contract spontaneously during a 24- to 48-hincubation with doxorubicin. The percentage of aggregates exhibitingautomaticity was concentration dependent between 0.01 and 1 n\i doxorubicin. At relatively high drug exposure (e.g., 1 MMdoxorubicin for 48h), beating was shown to be dysrhythmic. Whereas control aggregatesexhibited large stable resting potentials on impalement with intracellularmicroelectrodes, treated aggregates exhibited spontaneous action potentials with Phase 4 depolarization. Doxorubicin, in a dose-dependentmanner, increased the rate of Phase 4 depolarization, reduced the maximum diastolic potential, and shortened the action potential duration. Indysrhythmic aggregates, microelectrode recordings also revealed examples of prematuredepolarizations, extrasystoles, and droppedbeats. Thisstudy provides the first cellular electrophysiological recordings of doxo-rubicin-inducedautomaticity and rhythm disturbances in heart muscle.The results suggest that the induction of automaticity is due to a depolarizing action of doxorubicin on the cardiac membrane.
Doxorubicin, a major chemotherapeutic agent active againstcertain solid and hematological malignancies, is limited in itsclinical use by the development of acute and chronic cardiotoxiceffects (1,2). The most serious manifestation is a chronic dose-related cardiomyopathy that has been shown to increase dramatically above cumulative doses of about 550 mg/nr (3). Lesswell known is the tendency for doxorubicin to disturb thecardiac rhythm, sometimes resulting in life-threatening arrhythmias and sudden death (4). The drug-induced rhythm disturbances, which can be detected electrocardiographically in humans and animals, have been reported to occur acutely (withinthe first few hours), after long-term treatment, or within 24 to48 h following administration of doxorubicin (5-8). The acutedysrhythmias are similar following bolus injections or continuous infusions of doxorubicin. The occurrence of clinicallysignificant cardiac dysrhythmias prior to the development ofcardiomyopathy suggests that doxorubicin exerts early andsignificant effects on the membrane properties of heart cells.
Previously, studies of doxorubicin have concentrated on thechronic cardiomyopathy that is characterized by ultrastructuralalterations (e.g., myofibrillar loss and cytoplasmic vacuoliza-tion) and the destruction of biological membranes, apparentlythrough free radical-dependent lipid damage (9). In general, thesame histopathological changes and subcellular effects of doxorubicin that occur in humans develop in animal models (10).Also, in monolayer cultures exposed to doxorubicin, in which
Received 6/26/89; revised 2/8/90.' Supported by American Cancer Society Grant CH-437.2Submitted in partial fulfillment to the James Scholar Program for Independ
ent Study in the College of Medicine, University of Illinois. Present address:Department of Internal Medicine, Good Samaritan Medical Center, 1111 E.McDowell Road, Phoenix, AZ 85006.
3To whom requests for reprints should be addressed, at Department of
Pharmacology (M/C 868). University of Illinois College of Medicine, 835 SouthWolcott Avenue, Chicago, IL 60612.
the myocardial cells undergo similar ultrastructural changes,spontaneous beating ceases as the cells die (11, 12). Withreduced exposure to doxorubicin, arrhythmias could be produced in vitro (11). However, there have been no reports thusfar describing the cellular electrophysiological basis of doxo-rubicin induced aberrant automaticity in heart muscle at drugconcentrations used in a clinical setting. Therefore, in thepresent study, we analyzed the electrophysiological effects ofdoxorubicin, making use of an in vitro myocardial preparation,namely, chick embryonic heart cells cultured as spherical clusters, or aggregates.
Aggregates of cultured embryonic heart cells have manyadvantages for such a study, which have been summarized asfollows, (a) Embryonic heart cells remain viable in vitro fordays to weeks and exhibit contractile activity typical of theintact embryo heart, (b) The tissue culture approach makespossible the prolonged (e.g., 24-48 h) incubations with doxorubicin that are necessary for cardiotoxic effects to occur. Theeffects of doxorubicin on the cultured cells are direct withoutthe complications of drug action on neuronal and vasculartissues, (c) Recordings of both transmembrane potentials andcontractions can be made in aggregates by using microelectrodeand photoelectric techniques.
Furthermore, in aggregates of embryonic chick hearts, manyof the electrophysiological properties and pharmacological receptors observed are characteristic of the hearts from which thecells are isolated (13). Aggregates cultured from 7-day-oldembryonic ventricles, as used in the present study, typicallyexhibit a quiescent resting membrane potential, tetrodotoxin-inhibitable action potentials, and an absence of automaticity,much as the intact heart (14). These cultured cells also continueto respond in vitro to catecholamines, histamine, acetylcholine,and angiotensin II (15-18). Spherical aggregates retain the tightcell-to-cell electrical coupling characteristic of cardiac muscle(19). The slow calcium inward current and the fast (tetrodo-toxin-sensitive) sodium current occur in this preparation andhave been directly measured using the two-microelectrode voltage clamp (18, 20). Cell aggregates cultured from 7-day-oldchick embryonic hearts are capable, under certain conditions(e.g., in low extracellular K+ solutions), of developing pacemaker-like activity, i.e., spontaneously firing action potentialswith diastolic (Phase 4) depolarization. The ionic currentsunderlying this diastolic depolarization have been analyzed andresemble those found in adult cardiac Purkinje fibers (21).
In the present study, an in vitro myocardial preparation hasbeen used as a model system to investigate the possible mechanisms by which doxorubicin produces cardiotoxicity. The major findings are that doxorubicin exposure causes the appearance of spontaneous beating, which is sometimes dysrhythmic,in normally quiescent heart cell aggregates and that the alteredbehavior is associated with membrane depolarization, a phenomenon not previously described for cardiac cells of ventricular origin.
MATERIALS AND METHODS
Drugs. Doxorubicin was donated by Dr. Vern Verhoef on behalf ofAdria Laboratories (Columbus, OH).
on July 9, 2018. 1990 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from
ELECTROPHYSIOLOGICAL EFFECTS OF DOXORUB1CIN IN THE HEART
Culture Supplies. Fertilized eggs were obtained from Sharp Sales(West Chicago, IL). M199, fetal calf serum, and trypsin-EDTA werepurchased from GIBCO (Grand Island, NY). Trypan blue was obtainedfrom Sigma Chemical Co. (St. Louis, MO). Tissue culture dishes werepurchased from Falcon (Oxnard, CA), and bacteriological plates wereobtained from Fisher Scientific Co. (Itasca, IL). Glass coverslips (16mm2) were obtained from BlicoGlass Co. (Vineland, NJ), and NU-
serum was from Collaborative Research, Inc. (Bedford, MA).
Heart Cell Primary Culture
Preparation of Chick Cardiac Myocytes. Primary cultures of chickcardiomyocytes were prepared under sterile conditions by a modification of the method of Sachs and DeHaan (22). Hearts from chickembryos were excised on the seventh day in ovo. After discarding theatria, two slits in the apical portion of the ventricle were made tofacilitate blood removal. Eighteen ventricles were pooled at roomtemperature in culture medium composed of M199 and 10% fetal calfserum and containing antibiotics (10,000 units/ml of penicillin and 10mg/ml of streptomycin). To obtain a suspension of dissociated myo-cytes, the ventricles were transferred to a 25-ml Ehrlenmeyer flaskcontaining 0.05% trypsin-EDTA, triturated twice using a large-borepipet, and then gently agitated in a 37Cshaker bath for 7 min. The
supernatant containing dispersed myocytes was added to an equalvolume of M199 with 10% fetal calf serum to terminate the trypsinaction. Then, the supernatant was centrifuged at 500 x g for 5 min.Since it was found that mechanical agitation of the tissue withouttrypsin could produce cell separation to some extent, the undigestedventricular tissue was next resuspended in culture medium withouttrypsin and treated in all other respects exactly as described above.Four to five additional cycles of alternating trypsin and culture mediumwere used to completely digest the ventricles. The pellets of each digestwere pooled in culture medium with the exception of the first pelletwhich was discarded. The pellets were washed twice with culturemedium, centrifuged, and resuspended in culture medium to which 5mM HEPES4 buffer (pH 7.4) was added. In several cultures examined,
viability was greater than 90% by the Trypan blue exclusion test.Separation of Myocytes from Fibroblasts. Cardiac myocytes were
separated from fibroblasts on the basis of rapid attachment of fibro-blasts to tissue culture dishes (23)

domain: medical


Kristen Stewart Touches Down in Robert Pattinson's Hometown
Kristen Stewart was in her round sunglasses this morning when she touched down at Heathrow airport. She's in boyfriend Robert Pattinson's hometown of London for a few days, following a couple low-key weeks of rest after wrapping up work on Breaking Dawn. The end of shooting the Twilight series didn't offer much rest for Robert, who was then busy promoting Water For Elephants with costar Reese Witherspoon. Kristen was there to support him at various stops on the press tour and with kisses at the big NYC premiere. She stuck around the Big Apple afterward to hit up this year's Met Ball in a black and red Proenza Schouler number, and was later seen leaving the Bowery Hotel with her and Robert's rescue dog, Bear.


text:
John Sylva Feat Jill Colucci - Black Moon Rising download album
- Performer: John Sylva
- Title: Black Moon Rising
- Genre: Electronic
- Formats: AU MOD XM MP3 MPC DXD RA
- Released: 1986
- Style: Synth-pop
- MP3 album: 1672 mb
- FLAC album: 1264 mb
- Rating: 4.3/5
- Votes: 607
A. Black Moon Rising Featuring – Jill Colucci. B Black Moon Rising (Instrumental). From The Movie Black Moon Rising OST.
Featuring – Jill Colucci. B. Black Moon Rising (Instrumental).
Jill, who has been a singer/songwriter all of her life, released an album of her own songs. The CD, "No Regrets", features her hit compositions "No One Else On Earth", "Anymore" and "He Would Be Sixteen". Although Jill has enjoyed much commercial success, she has also experienced great loss. She refers to this period in her life as, The Lost Decade. During this time, her music changed, her heart was opened more fully, and her songs became the vehicles for her healing . John Sylva Feat Jill Colucci - Black Moon Rising (7").
Bad Moon Rising (Album Version).
Melodic Power Falconer. Album Name Black Moon Rising. Released date 06 June 2014. Labels Metal Blade Records. Music StyleMelodic Power. Members owning this album23. 2. Halls and Chambers. 3. Black Moon Rising. 4. Scoundrel and the Squire.
Album: Black Moon Rising.
The medieval riffs of the album opener, "Locust Swarm," make it hard not to imagine standing atop a mountain clad in glistening armor with a sword in each hand. Although the power fantasy elements of the music are engaging all on their own, the real surprise with Falconer 's music lies in its elegance. Format: MP3 320Kbps, FLAC.
Tracklist Hide Credits
|A||Black Moon Rising
Featuring – Jill Colucci
|B||Black Moon Rising (Instrumental)|

domain: entertainment


At least 30 workers belonging to BJP and Congress from different Village Panchayats and blocks in south Assam’s Cachar district joined the TMC (All India Trinamool Congress) on Friday.
They joined the party in the presence of Sushmita Dev, the new TMC Rajya Sabha MP from West Bengal.
Anadi Bhattacharjee, who was in charge of the BJP Social Media cell alleged that while he and others in the saffron camp had toiled hard for the party at the grassroots, the party appeared to drift away from its core principles in recent times.
He said that as a dedicated foot soldier of the party, he worked for over two decades and gave his best, but the BJP of today is more of a Congress-oriented BJP.
“We feel increasingly deprived. Also, the youths of Barak Valley are being deprived of government jobs against which we will raise our voice under the leadership of Sushmita Dev,” he said.
Sushmita Dev said that she is happy to see the increasing trust of the people.
“In the present-day political scenario in the state and across the country, the dictatorship exhibited by the BJP is detrimental for the public interest. No one talks about mass welfare and development which is why around 34 youths have decided to join us and I am happy to welcome them to the AITC family. I assure them and people at large that together we will continue to work for the people,” she said.


Aerohive Networks, a networking vendor that's bullish on the convergence of enterprise wired and wireless LANs, aims to raise US$75 million through an initial public offering.
Aerohive Networks intends to put branch offices' networks in the cloud for a monthly fee starting at US$99.
Two wireless LAN vendors are adding wired connectivity to their Wi-Fi offerings, to create managed, cloud-based networking services for a range of enterprise customers.
Bluesocket is offering its rebuilt enterprise Wi-Fi controller software on virtual machine platforms, the first one being VMware. The company will port the code for other hypervisor platforms in the future.
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First impression on unpacking the Q702 test unit was the solid feel and clean, minimalist styling.


text:
2 edition of Once-daily gentamicin dosing for the treatment of postpartum infections: a preliminary report found in the catalog.
Once-daily gentamicin dosing for the treatment of postpartum infections: a preliminary report
Written in English
|The Physical Object|
|Number of Pages||25|
The monitoring of therapeutic drugs involves measuring drug concentrations in plasma, serum or blood. This information is used to individualise dosage so that drug concentrations can be maintained within a target range. 1 Drug concentration at the site of action cannot be routinely measured, but the desired or adverse effects may correlate better with plasma or blood . Etiologies are similar to native valve infections 2 or more years post-op. EMPIRIC TREATMENT PLUS Gentamicin 1 mg/kg IV Q8H Viridans streptococci or S. bovis with PCN MIC Յ mcg/mL 6 weeks Ϯ Gentamicin 3 mg/kg IV .
Recommendations for the evaluation and treatment of fever in children generally use three different age groups: neonates from birth to 28 or 30 days of age,16, 17 young infants one to three months. Bradsher, R. W., Jr. and Snow, R. M. Ceftriaxone treatment of skin and soft tissue infections in a once daily regimen. Am J Med ;77(4C) View abstract.
Once-daily dosing and multiple-dosing with gentamicin both provide adequate serum levels, and either method has similar cure rates (Livingston, ). Because of potential nephrotoxicity and ototoxicity with gentamicin in the event of diminished glomerular filtration, some have recommended a combination of clindamycin and a second-generation. b.i.d.) or day (SOU nig/kg once daily) or vehicle (starch solu- tion 2%). At fetuses were explanted for skeletal evaluation. Postnatal studies were performed on rats treatcd from day 9 of gesta- tion until day 21 of lactation with either vehicle alone, indinavir or ritonavir ( mg/kg once daily).
The little boy Samuel
Linguistic derivations and filtering
Front porch stories at the one-room school
Of the making of CXXV books
Fiction writers guidelines
Report to the President, March 1, 1957.
Development and marine-resource conflicts in the southeast Asian/Australasian region
United Kingdom policy towards South Africa and the other states of the region
A users manual for a mathematical model to guide the discovery of tabular ore bodies, by John H. Schuenemeyer [and others]
hidden places of Devon and Cornwall
Systemic infections: 1 mg/kg IM or IV infusion (over 30 to minutes) every 8 hours-Duration of therapy: 7 to 10 days Life-threatening infections: Initial dose: 5 mg/kg IM or IV infusion (over 30 to minutes) per day, given in divided doses 3 to 4 times a day.
Background. Intraamniotic infection is associated with maternal morbidity and neonatal sepsis, pneumonia and death. Although antibiotic treatment is accepted as the standard of care, few studies have been conducted to examine the effectiveness of different antibiotic regimens for this infection and whether to administer antibiotics intrapartum or by: Once-daily dosing of gentamicin is appropriate given its proven efficacy in similar infections, ease of administration, theoretical improved eradication with concentration-dependent killing, and.
Aminoglycoside antibiotics have limited tissue distribution, are dependent on renal elimination, and have a narrow therapeutic index. Thus, careful selection of empiric dosing regimens and serum level monitoring are needed to ensure safety and efficacy of these drugs.
A once daily dose of gentamicin 5 mg/kg achieved a significantly higher peak SGL and safer trough than a twice-daily dose of mg/kg albeit about a. Introduction. Gentamicin (GM) is an aminoglycoside that is widely used in clinical conditions to fair clinical response.
It was isolated from Micromonospora inproving to be a breakthrough in the treatment of gram-negative (GN) bacillary infections, including those caused by Pseudomonas was introduced into parenteral usage in Endometritis is inflammation of the uterine lining.
It can affect all layers of the uterus. The uterus is typically aseptic. However, the travel of microbes from the cervix and vagina can lead to inflammation and infection.
This condition usually occurs as a result of the rupture of membranes during childbirth. Endometritis is the most common postpartum infection.
Tetracycline is recommended in guidelines as part of bismuth-based quadruple therapy (bismuth subsalicylate, metronidazole, tetracycline, and proton pump inhibitor for 14 days); however, dosing is not provided. 25 to 50 mg/kg/day PO in 4 divided doses (Max: mg/dose) is the FDA-approved dosage for other indications.
JOURNAL TOOLS. Get New Content Alerts. The treatment protocol for this intervention was continued from the existing MINI program, which included use of oral cotrimoxazole-p and gentamicin injection for possible infection in newborns. Gentamicins Subject Areas on Research.
- Levofloxacin mg IV q24h OR gentamicin 7 mg/kg/dose IV daily PLUS - Azithromycin mg PO/IV (IV for the first 24 hours, patient can be converted to PO after 24 hours) - Narrow coverage (ceftriaxone + azithromycin) OR levofloxacin if Pseudomonas is not.
General dosing, susceptible infection (Red Book [AAP] ): Infants, Children, and Adolescents: Mild to moderate infection: Oral: 5 to 12 mg/kg/dose; typically administered as 10 to 12 mg/kg/dose on day 1 followed by 5 to 6 mg/kg once daily for remainder of treatment duration; usual maximum dose for the total course: 1, to 2, mg.
An adult patient (weight 60 kg) has bacteremia suspected to be due to a gram-negative rod. Tobramycin is to be admin- istered using a once-daily dosing regimen, and the loading dose must be calculated to achieve a peak plasma level of 20 mg/L.
Assume that the patient has normal renal function. Bacterial infection—1–3 mg/kg/d in 3 divided doses to achieve a peak 5–10 mcg/mL and trough Once-daily treatment postpartum (5 mg/kg) Serum gentamicin levels were mg/L 2 days after discontinuation of the drug, the first ever report of measurable serum gentamicin resulting from topical administration.
Multidrug-resistant (MDR) Klebsiella pneumoniae represents an increasing threat to human health, causing difficult-to-treat infections with a high mortality rate.
Since colistin is one of the few treatment options for carbapenem-resistant K. pneumoniae infections, colistin resistance represents a challenge due to the limited range of potentially available effective antimicrobials. Show Summary Details. mg PO every 12 hours on day 1, then mg PO once daily.
For severe infections, mg PO every 12 hours. For sinusitis, clinical practice guidelines recommend mg PO twice daily or mg PO once daily for 5 to 7 days as second. The suggested dose is mg/kg once daily for preterm infants, 4 mg/kg once daily for newborn > 35 weeks of gestation and 5 mg/kg daily in two divided doses for neonates with severe infection.
4, 5 It is important to measure serum gentamicin concentrations when the drug is administered for more than 48 hours.
Acyclovir is approved by the Food and Drug Administration as a prescription drug that is commonly used as a topical, injectable, and oral treatment for genital herpes and cold sores. Herpes refers to a group of viruses that cause a variety of herpes infections including genital herpes, shingles, chicken pox (also chickenpox), cold sores, and encephalitis (inflammation of.
A Phase II, randomized, open-label, multicentre study demonstrated that sitafloxacin ( mg once daily) was as safe and as well tolerated as imipenem ( mg three times a day) for the treatment of pneumonia, including two cases of P.
aeruginosa pneumonia, one in each group. Aerosolized antibiotics.Read "A randomized, prospective study comparing once daily gentamicin with thrice daily gentamicin in the treatment of puerperal endometritis, American Journal of Obstetrics and Gynecology" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.Mitra AG, Whitten MK, Laurent SL, et al: A randomized, prospective study comparing once-daily gentamicin versus thrice-daily gentamicin in the treatment of puerperal infection.
Am J Obstet GynecolSoper DE, Kemmer CT, Conover WB: Abbreviated antibiotic therapy for the treatment of post-partum endometritis.

domain: health


Handi Architects complete new houses on a tricky sloping site
In the planning and design of a beautiful sloping site at the Peak with an existing single house, Handi’s prime target is to capitalise its full potential in terms of view while also maximising its development potential. A compact crescent road lead the visitors either up or down the terrain to the 4 houses sitting on terraces at 4 different levels. With the constraints of a sloping site, Handi has achieved a balance in capturing views and maximising frontage, and maintaining privacy with careful disposition and orientation of each house.
Each house is designed with its own individual layout and features to suit its particular location on site and viewing angles, and therefore exhibits its own character and appearance. The uppermost house on the upper terrace has a more rectilinear geometry and relation with the garden, while the house near the main entrance is characterised by its welcoming steps and garden along the approach to its entrance. The middle house develops around an edgeless pool and has an intimate and interlocking relation with the water, and the lowest house integrates with a stepping garden which is evolved around a preserved old tree.
The architectural identity of each house is developed under an embracing and consistent contemporary architectural language. At each house, as one approaches through the main door, the foyer opens up to a welcoming view of seemingly edgeless water surface linked with the infinity of the blue sky. The spacious entrance foyer flows through the winding stair to the upper level, and into the serene bedroom spaces which look onto the articulated garden and pool areas. Each house develops its own architectural character through the articulation of spaces in fluidity, subtle play of patterns and the intricate use of materials and colours. The architectural language permeates to landscape and interiors with thorough and meticulous co-ordination.


A minesweeper “Cherkasy” is a symbol of resistance to the Russian occupation of Crimea, it is the last military ship controlled by Ukraine in Crimea.
On March 20, after the occupation of Crimea began, the Russians issued an ultimatum to the Ukrainian military to join Russian Forces and gave them a day to make a decision.
On March 21, 2014, 12 sailors wrote a report on their dismissal and left “Cherkasy”.
The position of colleagues was supported by the landing ship “Konstantin Olshansky” and the minesweeper “Henichesk”.
The day before, in March 2014, two Russian ships, “Ochakov” and “Shakhtar”, and later two other ships, were flooded at the exit from Donuzlav Bay. Thus, a barricade was formed, which blocked the exit from the bay to the ships of the Ukrainian Navy.
On March 21, Russian helicopters began circling in the sky over Donuzlav, and snipers were stationed on the shore.
On the same day, the “Cherkasy” crew, led by Captain Yuri Fedash, attempted to escape from Donuzlav and reach Odessa, but unfortunately failed due to the danger of the shoals. On March 22, the ship was constantly plying Donuzlav, and the Russian military was watching. On March 23, the crew made another attempt to pass between two sunken Russian ships. Almost succeeded, but after the Russian boat hit, the bow of the Cherkasy was stranded, there was a hole in the hull, the rudder broke down. On March 24, after the Russians seized the ship “Konstantin Olshansky”, “Cherkasy” became the only warship on the Donuzlav River under the Ukrainian flag.
On March 25, the Russian military launched an assault, using two helicopters and three speedboats. Everything lasted more than two hours. “Cherkasy” opened fire, but rather to deter. The Russians also fired at the bow of the ship. The minesweeper’s steering system finally failed and the Russian military seized the ship. The crew finally left “Cherkasy” on the morning of March 26.
The film “Cherkasy” was made based on the events. The premiere took place on February 25, 2020.
We respect the courage of the Ukrainian military, admire their civic stance, loyalty to the oath and active actions in a seemingly hopeless situation. Resistance to the Russian occupation continues today.


text:
Novita Air Steriliser
I first wrote about sterilising the air conditioner HERE. Air conditioner cleanliness is a big thing for us because The Husband's nose shuts down when the air is polluted with fungal spores. For 20 years already, I have been sterilising the air conditioner on a weekly basis with jets of hot steam from the Karcher jet steamer. It did work. It kept the air conditioner reasonably clean. I have a rather keen sense of smell and could detect a light mould smell even after cleaning. The mould smell would get progressively heavier as the week progressed, and then it was time to clean the air con again. However, the Husband's nose did not protest and I had no better solution.
Till last week...
Last week, after steaming the air conditioners, I decided to use an ozone generator to sterilise the vents and ducts. The Novita Air steriliser comes with an air purifying function and an air sterilising (i.e., ozone generation) function. It occurred to me that at full ozone blast X 2 machines X 6 hours, I could generate enough ozone to sterilise BOTH the air conditioners (switched on to Fan Function) in our bedroom.
It worked marvellously well. After the treatment, the unit gave off not one whiff of mould smell. After one week, there is only a slight mould smell. So now, I shall ozonify the air conditioners once a week.
Ozone is poisonous to the human lungs. Whenever I switch on the air sterilising function of the Novita Air Steriliser, I make sure no human/pet stays in the room. The instructions state that at very low ozone settings, there is not enough ozone to harm the lungs. Supposedly, it is safe to stay in the room. I never take that chance. If the levels of ozone are too low to harm your lungs, they are not high enough to kill fungal spores and bacteria in the air. If the levels of ozone are high enough to kill fungal spores and bacteria, then our lungs are in danger too.
With no one in the room, I close all the doors and windows. I switch 2 machines on to full ozone blast. This ensures that there is enough ozone build-up to be toxic to mould and bacteria. The air conditioners are switched on to Fan Function so that they will suck in ozone and blow it out again. As the ozone circulates through all vents and ducts for 6 hours, it will oxidise every single bacteria and fungal spore in there.

domain: chemistry


text:
The bill is named after a girl who was raped and burned to death in New Mexico in 2003.
Rep. Mel Watt (D-S.C.) said the Supreme Court is about to rule in the coming months on this issue, since it has decided to review the case Maryland v King case. Watt said he voted for a similar version of this bill before, but said this case is raising new questions that should be answered before Congress acts.
"The last time I voted for the bill, or one similar to it, I viewed the collection of arrestee DNA as essentially the same from a constitutional point of view to the collection of fingerprints, which are collected and preserved in the database for arrestees whether there's a conviction or not," he said.
"Since then, however, serious questions have been raised about the constitutionality of arrestee DNA collection, and the preservation of that information in a database where there has been on subsequent conviction."
Watt was joined by House Judiciary Committee ranking member John Conyers (D-Mich.), who said members have "tossed procedure into the wastebasket."
Rep. Hank Johnson (D-Ga.) argued that Congress should not support practices that could be seen as unconstitutional, and said he fears these practices will hurt minorities.
"I'm also concerned that this practice would perpetuate the current racial disparities in our criminal justice system," Johnson said. "As more minority DNA profiles are included in databases, more minorities are potential suspects, regardless of their actual guilt.
"We cannot allow this injustice to blossom in a free country where people are presumed innocent until proven guilty."
House passage sends the bill to the Senate, which may simply ignore it given the Democratic opposition seen in the House.

domain: law


text:
Sue and Tharini were the ones who drew attention to this. I wished to contribute in time of the food allergy awareness month. I am no expert but I list down here some of the allergies I have come across.
I had not come across food allergies much, expect in the novels which talked of peanut allergy and even death through that.
My mother is allergic only to panner which causes her face to break into small pimple like eruptions and my chithi ( aunt) is allergic to yam which causes in her a similar reaction.
Sometimes colacasia( arbi/ chaypankezhangu) can cause severe itchiness in the throat. But that is a matter of luck. There is no way to tell as far as I know till you begin eating it. And it is only a mild irritation. Not life threatening or any such.
Since I moved to Chennai post marriage, I have encountered a few more food allergies.
I know that asthmatics avoid cucumber/ snake gourd/ bananas during periods of wheezing. My MIL is one such.
Navy's cousin has milk intolerance to such an extent that she has to avoid not just milk but anything with even traces milk - so she has never had chocolate, cake, curd, milk, bread, butter, cheese, pizza, naan, white gravies, etc. This causes a lot of anxiety among us when we go out to eat because even a roti dough may have some milk or a seemingly tomato gravy may have cream in it. There have been occasions when she was nearly choked due to the restaurant not taking our request seriously enough.
It is only when I saw her that I realized how distressing and disruptive an allergy could be.


text:
“HUGE” is the Canadian stock ticker for FSD Pharma Inc (CSE:HUGE) (OTCQB: FSDDF) (FRA:0K9) and it hints at the size of the company’s aspirations. Its aim? The development of high-quality, indoor-grown, pharmaceutical-grade cannabis. But it’s even more than that. The company intends to target all legal aspects of the cannabis industry: cultivation, processing, manufacturing, extracts […]
The market gyrations and the shutdown. The trade wars and global uncertainty. None of the above has squashed the sunny optimism that a group of healthcare CEOs demonstrated at a roundtable discussion during the annual J.P. Morgan Healthcare Conference in San Francisco last week.
Private, Dublin-based biotech United Neuroscience says it plans to rapidly advance its active Alzheimer’s vaccine immunotherapy UB-311 after reporting positive top-line results from a Phase IIa study of 42 patients on Jan. 16. The company’s lead candidate UB-311 is a novel synthetic peptide that targets beta amyloid in Alzheimer’s disease, with the goal of preventing and treating […]


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Hostel facilities for tribal children to be strengthened
Thrust has been given to education in the Integrated Tribal Development Programme (ITDP) in the district.
According to Aruna Giri, project officer, ITDP, this year's programme throughout the State lays stress on the education of tribal children. As part of this, hostel facilities will be strengthened to accommodate more tribal students.
Apart from economic backwardness, a major reason for high dropout rate among tribal students was the lack of hostel facilities, he said.
Mr. Giri said that an amount of Rs.2 crore had been earmarked this year for building about 150 houses for tribals. The first phase of construction, with the advance given, was almost over. However, in some areas construction was delayed owing to the difficulty in arranging construction materials, as most of the tribal settlements were in remote places.
Funds would be distributed in accordance with the completion of work in each phase, he said.
For improving the living conditions of tribal people, dairy sector would be strengthened. Cattles would be distributed to them. Through the Food Support Scheme, ration would be distributed.
The beneficiaries for the schemes would be selected by ‘Orrukoottam' (tribal leaders' council) and would be approved by the panchayat council.
Thattekannu in Adimaly village and Pollavayal in Kanthallur would be given Special Central Assistance for overall development.
A special package for Edamalakkudy tribal grama panchayat had been submitted to the government. The support of various departments, including forest, agriculture and health, was necessary to improve the living conditions there, he said.


Secretary of Education Miguel Cardona issued the following statement today on President Biden’s intent to nominate Roberto J. Rodríguez for Assistant Secretary of Planning, Evaluation and Policy Development at the U.S. Department of Education:
“I am grateful President Biden has nominated Roberto J. Rodríguez to serve as Assistant Secretary of Planning, Evaluation and Policy Development at the U.S. Department of Education. As the son of public-school educators and the grandson of immigrants, Roberto has devoted his career to organizing, supporting, and elevating the voices and vision of educators in the policy-development process. He has a strong track record of shaping bipartisan policy solutions that are informed by the experiences of educators. Roberto is also a fierce advocate for educational equity who will ensure we prioritize, replicate and invest in solutions that work for all students. I am thankful he has once again answered the call to serve our nation’s students and look forward to his confirmation.”
About Roberto J. Rodríguez
Roberto Rodríguez brings extensive policy leadership, expertise, and lifelong commitment to advancing educational equity and opportunity.His distinguished career in public service includes senior government roles across two presidential administrations, on the White House Domestic Policy Council and in the U.S. Senate for the late U.S. Sen. Edward M. Kennedy (D-MA). His dedication to education began by elevating the voices of Latino families, students and educators. Over the past two decades, he has played a key role in virtually every major education policy effort and legislative reform at the national level.
Rodríguez is currently President and CEO of Teach Plus, a national non-profit organization dedicated to elevating teacher leadership and voice to advance educational equity. The son of public school educators, his parents and grandparents immigrated to the U.S. from the Dominican Republic, Venezuela and Mexico. Rodríguez grew up in Grand Rapids, Michigan, and holds a B.A. from the University of Michigan and an M.Ed. from Harvard University. He lives in Washington, D.C., with his wife and two children.


text:
Interaction Effect of Arbuscular Mycorrhiza and Redroot Pigweed (Amaranthus retroflexus L.) on Growth and Yield of Sunflower under Water Stress Conditions
Tulīd va Farāvarī-i Maḥṣūlāt-i Zirā̒ī va Bāghī
The management of soil elements by biological fertilizers is considered as an important attribute of sustainable agriculture. In order to evaluate the interaction effects of Arbuscular mycorrhizal fungi and redroot pigweed (Amaranthus retroflexus L.) on growth and yield of sunflower (Helianthus annuus L.) under water stress conditions, a field study was conducted in 2015 at School of Agriculture, Shiraz University, Shiraz, Iran. Water stress at three levels (60, 80 and 100% FC) as main factor,
... C) as main factor, mycorrhizal fungi at two levels (with and without fungi) and redroot pigweed at two levels (weedy and weed free) were used in three replications based on factorial in sub plots. Results showed that seed yield reduced the by 42% under weedy conditions and applying mycorrhizal fungi compensated the grain yield decrease by 29%. Weed in moderate and severe water stress conditions caused seed yield reductions of 35 and 52%, and applying mycorrhizal fungi compensated grain yield loss by 4 and 51%, respectively. Mean comparisons for severe water stress and weedy treatment interaction showed oil yield, biological yield and harvest index reduced by 57, 36 and 25% and applying mycorrhizal fungi compensated oil yield, biological yield and harvest index decreases by 63, 25 and 20%, respectively. In general, it seems that the application of mycorrhiza can improve growth and yield characteristics of sunflower under water stress and weedy conditions.


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"Then there was the comment from state Rep. Joe Salazar.
He said that a woman who feels threatened by rape on a college campus doesn’t need to be armed because she can use a call box to get help.
Salazar’s statement came in a debate over a proposal to ban citizens possessing a concealed-carry permit from being armed on university campuses.
“It’s why we have call boxes,” said Salazar, “it’s why we have safe zones, it’s why we have the whistles. Because you just don’t know who you’re gonna be shooting at.
“And you don’t know if you feel like you’re gonna be raped, or if you feel like someone’s been following you around, or if you feel like you’re in trouble when you may actually not be, that you pop out that gun and you pop … pop a round at somebody.” "
They left out the part of explaining the universal time out signal respected by criminals allowing someone to retrieve a weapon or to get to an equally respected safe zone.
And on another note, I'll be writting up some legislation protecting our great citizens from the dangers of whistles. It's truly a sad story the hundreds suffering hearing loss from those who so caulously blow a whistle without regard to the damage caused to the inocent victims nearby. Tenitus is no joke my friends.


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To find the best bed pillow on the market, we spent about 45 hours poring over every viable source we could think of. From third-party and customer reviews to sleep and health statistics, we covered all the bases.
If you are fortunate to have an attic in your home, if you haven't converted it already, you may be missing out on prime real estate for a master bedroom. An attic master bedroom enables you to have privacy, optimum views to the outside, and you can claim this extra square footage if you decide to sell your home. If you want to turn your attic into a master bedroom, here are some tips to see if it works for your home and lifestyle.
A teen will most appreciate an approach to their room as their mini, self-contained apartment where they can spend most of their time comfortably. Regardless of size, a teen's bedroom needs to be versatile enough for them to spread out and get homework done, hang with friends, lounge and sleep, all while reflecting their personality.
Have a one of room area you had similar to partition? This figured timber headboard utilizes black to mark a modern room for sleeping.


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Your Mother is always with you.
She's the whisper of the leaves as you walk down the street.
She's the smell of certain foods you remember, flowers you pick and
perfume that she wore.
She's the cool hand on your brow when you're not feeling well.
She's your breath in the air on a cold winter's day.
She is the sound of the rain that lulls you to sleep, the colors of a
rainbow. She is Christmas morning.
Your Mother lives inside your laughter.
She's crystallized in every teardrop.
A mother shows every emotion...happiness, sadness, fear,
jealousy, love, hate, anger, helplessness, excitement, joy,
sorrow... and all the while, hoping and praying you will only know the good
feelings in life. She's the place you came from, your first home, and she's
the map you follow with every step you take.
She's your first love; your first friend,
nothing on earth can separate you.
Not even death.


Continuing to rely on asset-price appreciation to provide for our futures is a dangerous gamble
Any way one looks at it, the long-term growth prospects of the British economy appear pretty bleak in the absence of some quite seismic shifts in economic thinking and economic policy practice. Yes, you might protest, growth is back, inflation is low, unemployment is falling and there is no immediate prospect of a steep upward trajectory in interest rates. But, as even the Governor of the Bank of England and the Chancellor of the Exchequer both now concede, the growth we have looks alarmingly unstable and would appear to be predicated on the inflation of an all-too-familiar asset-price bubble centred on the housing market.
That is why the coalition’s much-touted Help to Buy scheme is currently in the dock and why the Chancellor’s recent Mansion House speech freely concedes the need of the Bank of England to cap mortgage loan-to-value ratios to temper the overheating in the housing market. But, of course, not quite yet … indeed, not in any way capable of yielding tangible effects (and thereby suppressing growth) this side of the General Election.
This is alarming for two reasons. First, and perhaps most obviously, it suggests (in what is now becoming a familiar theme in this blog) that Britain’s seemingly good economic performance in recent months is in fact a chimera – and that the quite conscious pump-priming of the housing market has merely served to mask the persistence of long-standing structural pathologies that remain almost entirely unaddressed. The growth crisis, in effect, has not been resolved – and that makes the debt crisis much, much more difficult to deal with in the medium term.
But, second, and much less appreciated, this has very major welfare implications. The reason is very simple. Since around the turn of the century, Britain has been moving increasingly consciously from a public model of welfare to what might be seen as a ‘public-plus’ welfare model – residual public welfare plus a more individualised and privatised ‘asset-based’ welfare. And the point is that austerity is driving a further residualisation of public welfare, just as the crisis has put paid to the steady asset-price appreciation on which asset-based welfare depends. It is time to twist or split – not, as the Bank of England and the Chancellor would seem to be conspiring to do, to postpone the decision until after the General Election.
To see why, we need to return to the crisis itself. As I have been suggesting, it was not just the Anglo-liberal growth model that was threatened by the bubble burst. So too were a range of public and social policies whose development had been predicated on the assumed continuation of growth in general and of a broader asset-led conception of growth more specifically. Chief amongst these is the pursuit of asset-based welfare. This was – and remains – an approach to welfare in which citizens are encouraged to acquire, as a form of investment, appreciating assets which they might later liquidate to fund their welfare needs. It has become associated in particular with the idea that citizens, rather than the state, bear the principal responsibility for ensuring that they have (or might have) adequate funds to meet their needs in retirement, ill-health or even unemployment without becoming dependent on their families.
In the context of an ageing population and with the projected steep decline in the per capita value of public pensions, asset-based welfare provided a means of squaring an increasingly tricky welfare circle. But the problem was that the stable and predictable asset appreciation on which it rested was, like the Anglo-liberal growth model itself, dependent on easy access to credit and the persistence of a ‘low inflation–low interest rate’ equilibrium. It was, in other words, fine only for as long as the benign conditions of the ‘great moderation’ persisted – and these were never going to last forever. Asset-based welfare was, in effect, a way of mortgaging the future capacity of citizens to provide for themselves with dignity on the vagaries of the housing market (and markets in other appreciating assets classes).
Put in such terms, asset-based welfare looks today like a rather risky and ultimately costly one-way accumulator bet. And it was. But, to those who assumed that the business cycle was dead, asset-based welfare was a very sensible public policy stance. For as long as asset-prices were rising and there was no prospect (in the absence of a business cycle) of them falling, it was almost bound to deliver a good return to those able to participate in the process. As such, it was perfectly rational for policy-makers to promote it as a strategy for supplementing more conventional means of meeting welfare needs publicly.
What of course made it all the more attractive to policy-makers was Britain’s creeping welfare residualism from the mid 1980s. This growing residualism reinforced the incentive to promote asset-based welfare as a means of partially compensating citizens for the growing mismatch between the benefits to which they were entitled and their expectations of the benefits they might receive.
But the problem was that the attractiveness of asset-based welfare to policy-makers in Britain did not make it a very good bet. Indeed, despite being so widely promoted and touted, it has actually proved extremely fortunate that the transition to asset-based welfare was rather more gradual and incremental than one might have been forgiven for thinking, given the hype. By the onset of the crisis only one major asset-based welfare programme was actually up and running – the Child Trust Fund. And even this was only fully operative from 2005. Yet, despite this, close to £0.5 billion has been lost from the value of these funds since 2008. The mortgaging of childhood futures on continued asset-price appreciation has proved one of the least mourned casualties of the crisis.
Or has it? For asset-based welfare has not gone away, even if it now assumes a quieter form. Indeed, as hinted at above, something equivalent to asset-based welfare (a privatised alternative to public provision) looks all the more necessary in the context of pervasive welfare austerity. But, as we now know all too well, the need for asset-based welfare to compensate for a shortfall in public provision has grown at precisely the point when stable asset-price inflation appears oxymoronic.
This is the asset-based welfare paradox. And it needs to be faced up to now. The choice is a stark one: ignore the lessons of the crisis and continue to mortgage our collective futures on the bet that asset-price inflation can be made sustainable indefinitely (twist) or share the burden of managing for our futures collectively and publicly (split). I guess that makes me a splitter.
This blog derives from a comment delivered at a public seminar at Le Ministère des Affaires Sociales et de la Santé (DREES) in Paris on stratégies nationales de croissance et protection sociale (‘national growth models and welfare provision’) on 26June 2014.


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The word "pistol" is often synonymous with the word "handgun". Some handgun experts make a technical distinction that views pistols as a subset of handguns. Sometimes in usage, the term "pistol" refers to a handgun having one chamber integral with the barrel, making pistols distinct from the other main type of handgun, the revolver, which has a revolving cylinder containing multiple chambers. The pistol originates in the 16th century, when early handguns were produced in Europe. The English word was introduced in ca. 1570 from the Middle French pistolet (ca. 1550).The etymology of the French word pistolet is unclear. It may be from a Czech word for early hand cannons, píšťala "flute", or alternatively from Italian pistolese, after Pistoia, a city renowned for Renaissance-era gunsmithing, where hand-held guns (designed to be fired from horseback) were first produced in the 1540s.
A submachine gun (SMG) is an air-cooled, magazine-fed, automatic carbine designed to fire pistol cartridges. The term "submachine gun" was coined by John T. Thompson, the inventor of the Thompson submachine gun. The submachine gun was developed during World War I (1914–1918). At its zenith in World War II (1939–1945), millions of SMGs were made. Today, submachine guns have been largely replaced by assault rifles, which have a greater effective range and are capable of penetrating ballistic helmets and body armor used by modern infantrymen. However, submachine guns are still widely used by police and military special forces, who value the SMG's reduced recoil and noise signature, especially when suppressed. Its reduced risk of overpenetration is also a particularly valuable trait to police forces. In the early 20th century, experimental machine pistols were made by converting pistols such as the Luger P-08 and Mauser C96 from semiautomatic to full-automatic operation and adding detachable stocks. Carbine-type automatic weapons firing pistol rounds were developed during the latter stages of World War I by Italy, Germany and the United States. Their improved firepower offered an advantage in trench warfare. In 1915, the Italians introduced the Villar-Perosa aircraft machine gun. It fired pistol-caliber 9mm Glisenti ammunition, but was not a true submachine gun, as it was originally designed as a mounted weapon. This odd design was then modified into the Beretta OVP carbine-type submachine gun, which then evolved into the Beretta Model 1918 after the end of World War I. Both the Beretta OVP and the Model 1918 had a traditional wooden stock, a 25-round top-fed box magazine, and had a cyclic rate of fire of 900 rounds per minute.
An assault rifle is a selective fire rifle that uses an intermediate cartridge and a detachable magazine. Assault rifles are currently the standard service rifles in most modern armies. Examples of assault rifles include the StG 44,AK-47 and the M16 rifle. The Germans were the first to pioneer the assault rifle concept, during World War II, based upon research that showed that most firefights happen within 400 meters and that contemporary rifles were over-powered for most small arms combat. They sought to develop a select-fire intermediate powered rifle combining the firepower of a submachine gun with the accuracy and range of a rifle.This was done by shortening the standard 7.92x57mm cartridge to 7.92x33mm and giving it a lighter 125 grain bullet, that limited range but allowed for more controllable automatic fire. The term assault rifle is a non-direct translation of the German word Sturmgewehr (literally "storm rifle", "storm" as in "military assault"). The name was coined by Adolf Hitler as a new name for the Maschinenpistole 43,subsequently known as the Sturmgewehr 44, the firearm generally considered the first assault rifle that served to popularize the concept and form the basis for today's modern assault rifles. The translation assault rifle gradually became the common term for similar firearms sharing the same technical definition as the StG 44. In a strict definition, a firearm must have at least the following characteristics to be considered an assault rifle.
A machine gun is a fully automatic mounted or portable firearm, usually designed to fire bullets in quick succession from an ammunition belt or magazine, typically at a rate of three to eighteen hundred rounds per minute. A machine gun is often portable to a certain degree, but is generally used when attached to a mount or fired from the ground on a bipod or tripod, and generally fires a rifle cartridge and is capable of sustained fire Unlike semi-automatic firearms, which require one trigger pull per round fired, a machine gun is designed to fire for as long as the trigger is held down. Nowadays the term is restricted to relatively heavy weapons fired from some sort of support rather than hand-held, able to provide continuous or frequent bursts of automatic fire for as long as ammunition lasts. Machine guns are normally used against unprotected or lightly protected personnel, or to provide suppressive fire. Some machine guns have in practice sustained fire almost continuously for hours; other automatic weapons overheat after less than a minute of use. Because they become very hot, practically all machine guns fire from an open bolt, to permit air cooling from the breech between bursts. They also have either a barrel cooling system, or removable barrels which allow a hot barrel to be replaced.
In military and law enforcement terminology, a sniper rifle is a precision-rifle used to ensure more accurate placement of bullets at longer ranges than other small arms. It is a common misconception that any scoped rifle is a sniper rifle, and while certain long guns are more suited for the application than others, it is the act of using a weapon strategically as a sniper that designates it as such. A typical sniper rifle is built for optimal levels of accuracy, fitted with a telescopic sight and chambered for a military centerfire cartridge. The term is often used in the media to describe any type of accurized firearm fitted with a telescopic sight that is employed against human targets, although "sniping rifle" or "sniper's rifle" is the technically correct term for such a rifle. The Whitworth rifle was arguably the first long-range sniper rifle in the world. Designed by Sir Joseph Whitworth, a prominent British engineer, it used twisted hexagonal barrels instead of traditional round rifled barrels, which meant that the projectile did not have to bite into grooves as was done with conventional rifling. His rifle was far more accurate than the Pattern 1853 Enfield, which had shown some weaknesses during the recent Crimean War. At trials in 1857 which tested the accuracy and range of both weapons, Whitworth's design outperformed the Enfield at a rate of about three to one. The Whitworth rifle was able to hit the target at a range of 2,000 yards, whereas the Enfield could only manage it at a distance of 1,400 yards.


Keywords: leather industry, tanneries, profitable environmental management, PREMA, sustainable development, Morocco, sustainability, tanning units, environmental pollution, tannery waste
Applying the principles of sustainable development in the leather industry in Morocco: tannery case
Tanning is the intermediate stage in production of leather products and it is the most negative aspect in terms of industrial pollution in the leather sector in Morocco. At present, the main concern of tanning units is the consideration of sustainable development in the competitive modernisation of this sector whose added value is important for the national economy. The introduction of the profitable environmental management (PREMA®) tools (GTZ, P3U, 2006) in tannery units, has achieved a triple win: economic, environmental and socio–organisational. The dynamics efficiency gains and the quantitative results presented have motivated the company to engage in sustainable development path.


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On Her Majesty's Secret Service.London: Jonathan Cape, 1963 Stock Code: 137722
Superb presentation copy, inscribed by Fleming to Noël CowardFirst edition, first impression, superb presentation copy, inscribed by the author to Noël Coward, "To Noël This slice of real Swiss life! With love Ian", with Coward's bookplate to the front pastedown. To Coward, who at the time of publication was living as a tax exile in his mountain home in Switzerland, Fleming humorously suggests that his latest James Bond novel, set in Switzerland, represents the reality of life in that country.
Noël Coward (1899-1973) was one of Fleming's closest friends. In 1948 Coward visited Jamaica where he rented Goldeneye from Fleming for a week: "On arrival, a boyish, teasing friendship and good-natured rivalry over Jamaica began between Coward and Fleming. During his visit, Coward celebrated Goldeneye with a song that complained about the airless rooms and the hardness of Fleming's furniture... Sardonically he referred to his host's home as 'Golden Eye, Nose and Throat' because it reminded him of a hospital. Fleming, too, enjoyed the sparring and wrote about the outcome of Coward's first visit... 'He Coward then went off, and, as close to me as he could get, built a house (what am I saying - four houses) and - to hell with the charms of Bermuda and Switzerland! - comes here every year" (Brooks, p. 226). During his time in Jamaica, Coward penned his play, Volcano, which featured characters based on his expat friends, including Ian and Ann Fleming; it was never produced in Coward's lifetime.
Coward was a witness at Fleming's wedding to Ann in 1952 and became godfather to their son Caspar. Ann wrote to Cecil Beaton of the occasion: "I dare hardly admit it but Noël is a godfather, an act of treachery on my part as we thought he would be offended if not asked as he considers himself responsible for the whole thing. When he appeared last Sunday he was quite delightful for the first hour and then so vulgar and dull that I longed to cancel the G-parent arrangement and be frightfully rude to him." Coward owned a holiday house in Dover until 1951, when he sold it to the Flemings, which inspired Fleming to set Moonraker in Kent.
Octavo. Original brown cloth, (binding A, no priority of issue), spine lettered in silver, ski track design to front cover in white. With the dust jacket. Housed in a black quarter morocco solander box by the Chelsea Bindery.
Faint stain to top edge, foot of spine a little bruised. A very nice copy, contents clean, in the pleasingly bright original dust jacket, with tiny mark to head of spine panel and fold of rear flap, not price-clipped.
Gilbert A11a (1.1). Victoria Brooks, Literary Trips: Following in the Footsteps of Fame, Volume 1 (2002).
With the exception of framed items*, Peter Harrington offers free delivery on all UK orders of rare books, maps and prints placed through this website. Delivery to USA and the rest of the world is similarly free for orders over £200.
Established in 1969, Peter Harrington is one of the leading rare book firms in the world. It is a proud member of the Antiquarian Booksellers Association – along with ILAB, the PBFA and Lapada – and from shops in Mayfair and Chelsea, London, sells rare books, prints and ephemera to customers across the world.
Tel: +44 (0)20 7591 0220

domain: artistic


The 'Fast & Furious' women refuse to take a back seat
Over the course of 12 years, the six “Fast and the Furious” movies have evolved from over-the-top street-racing dramas to over-the-top action adventures.
Yet, amid the eye candy and vroom-vrooming, the franchise has seen an evolution — and a revolution — of its female characters.
Mia Toretto (Jordana Brewster) started as a wallflower in “The Fast and the Furious” in 2001, and now she's a mom who will do anything for her family. Michelle Rodriguez's Letty Ortiz lived, died and lives again in “Fast & Furious 6,” now in theaters.
And, a decade ago, there was no female role like Riley, the strong, no-nonsense federal agent played by former mixed-martial-arts champion Gina Carano, who will happily throw a bone-crushing armlock on someone if they look at her the wrong way.
“The women are so often just supporting the male leads and barely really do anything in the film,” says Brewster, adding that “F&F 6” director Justin Lin's modus operandi is to have “the women be strong and as complex as the male characters.”
The higher profiles for the women also attract female audiences, whether they go alone or are dragged by their boyfriends, Rodriguez says.
The two stalwart Furious guys, Dom Toretto (Vin Diesel) and Brian O'Conner (Paul Walker), are back to help take down an international car-heist ring, but women are a major part of the action, too.
Mia and Brian are now the parents of a little future racer, and the new mission raises the stakes for Dom and Brian.
Dom also has to deal with the return of Letty, who was presumed dead after the fourth film but now, as a result of amnesia, is a crew member for the villain, Shaw (Luke Evans).
Protecting Letty's integrity has been a “battle” over the years, Rodriguez says. The first script of the original film didn't empower her character: She was disloyal to her racer soulmate Dom, lacked fight and had horrible lines. Rodriguez successfully fought for changes.
A sign of how far “Fast” females have come is showcased in a brawl between Rodriguez's Letty and Carano's Riley that is chock full of fisticuffs, tile-busting spinning kicks, head-butts and even some biting.
Letty seems outmatched by her military adversary, and Rodriguez felt the pressure to make it realistic vs. Carano.
“I'm a small chick compared to her, so I wanted to make the audience feel like there's a possibility that Letty's not going to get through this,” she says. “I felt like I had every tomboy in the United States and around the world egging me on: ‘You better freaking nail this.' ”
Carano says she'll think it a huge compliment if female fans come out of “F&F 6” feeling more empowered than their male counterparts after seeing her and her fellow actresses.
Brian Truitt is a staff writer for USA Today.
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Students recently embarked on our first programs to America’s Last Frontier – Alaska! Travelers explored Anchorage, observed birds at Potter Marsh, visited Denali National Park to look for wildlife, and stopped by the Iditarod Headquarters where they were able to meet a number of sled dogs.
“The Alaska program allowed students to explore natures in a hands-on format that kept them engaged,” says Vice President of Curriculum and Academics Wendy Amato. “Students were enthusiastic about the wildlife, the exit glacier hike, the cultural interactions and, certainly, the sled dog puppies at the Iditarod Center!”
As more students gear up to travel to Alaska with us, we gathered 10 interesting facts about America’s Last Frontier.
- Aurora borealis – the northern lights – can be seen an average of 243 days a year in Fairbanks.
- Alaska is less than 50 miles from Russia.
- The state accounts for 25 percent of the oil produced in the United States.
- Alaska is the only state name that can be typed on one row of a keyboard.
- 17 of North America’s 20 highest peaks are in Alaska, including the highest peak, Denali, which is 20,320 ft. above sea level.
- Alaska contains more than 100 volcanoes and volcanic fields which have been active within the last two million years.
- Alaska has more coastline than the rest of the United States combined (more than 34,000 miles), more inland water than any other state (20,171 square miles), and is the only state to have coastlines on three different seas – the Arctic Ocean, Pacific Ocean, and Bering Sea.
- The only battle during World War II that was fought on American soil took place in 1943 after the Japanese invaded the Aleutian Islands.
- The United States purchased Alaska from Russia in 1867. Secretary of State William H. Seward paid $7.2 million, or two cents per acre, for Alaska.
- Alaska’s capital Juneau is the only state capital in the United States with no road connecting the city to the rest of state or to the rest of North America as the terrain is too rugged to build a road. All goods coming in and out must go by plane or boat.

domain: geography