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Cancers 2010, 2(2), 513-522; doi:10.3390/cancers2020513
Abstract: Alkylresorcinols [ARs] have been proposed for use as biomarkers of whole-grain intake. The aim here was to examine the responsiveness of AR metabolites to rye intake. Sixty women were divided into three groups according to their rye consumption. We observed significant differences between groups in plasma 3-[3,5-dihydroxyphenyl]-1-propanoic acid [DHPPA] and in urinary DHPPA and 3,5-dihydroxybenzoic acid [DHBA]. In addition, these AR metabolites increased proportionally to rye fiber intake. We conclude that these ARs metabolites are accurate and useful biomarkers of rye fiber intake. Further studies are needed to confirm our results in larger and different populations.
Epidemiologic evidence for beneficial effects of whole-grain consumption on risk of several chronic diseases, including cardiovascular disease, diabetes, obesity, and certain types of cancer, has emerged [1,2]. These effects are caused by several components of the dietary fiber complex . These studies are generally based on self-reported whole-grain intake. However, assessment of self-reported whole-grain intake could lead to measurement errors . Furthermore, different definitions of whole grain have been used in different studies and countries . Because of the poor accuracy in measuring intake of foods and nutrients  and the inherent weaknesses of food frequency questionnaires [3,4] in nutritional epidemiologic data, specific biomarkers for whole-grain cereal fiber intake could add critical support to epidemiological results and would overcome some serious drawbacks. Alkylresorcinols [ARs], amphilic 1,3-dihydroxy-5-alkylbenzene homologs with odd-numbered alkyl side-chains from C17:0 to C25:0 , are found in abundance in the fiber layers of rye and wheat grains, but are absent or limited in germ or endosperm layers and in most other foods . AR intake can be followed by determination of their metabolites (3,5-dihydroxybenzoic acid: DHBA and 3-[3,5-dihydroxyphenyl]-1-propanoic acid: DHPPA) in plasma and in urine [9,10,11]. Ross et al.  showed that 45–71% of ingested ARs are absorbed. ARs have been proposed to function as biomarkers for whole-grain intake due to these properties [8,13]. Because of the specific occurrence of ARs in the fiber complex of whole-grain wheat and rye, intact plasma ARs and urinary AR metabolites have been proposed to be better biomarkers than enterolactone for the consumption of fiber-rich cereals in Nordic [14,15,16] and American populations . However, the half-life of intact plasma ARs is around 5 h, which is a short or medium half-life . AR metabolites are possibly formed via β-oxidation of intact plasma ARs . The responsiveness of intact ARs and urinary metabolites in an interventional rye bread study was previously demonstrated to be related to the amount of rye ingested by subjects, during the protocol . However, we showed that AR metabolites, and more specifically AR metabolites in plasma, correlate more strongly with cereal fiber intake than do intact plasma ARs [14,19]. In addition, our preliminary analyses indicated, that the half-life of plasma AR metabolites is longer than 5 h (~10–15 h).
AR metabolites seem to be more accurate biomarkers than intact plasma ARs of whole-grain rye and wheat intake [14,15,19]. To confirm that urinary and plasma AR metabolites can be used as sensitive and specific biomarkers, evaluation of the response of these metabolites to rye intake is important. Thus, our objective was to examine the responsiveness of urinary and plasma AR metabolites to rye intake in Finnish women.
2. Results and Discussion
We observed no significant difference between groups for age, weight, BMI, age at menopause, age at menarche, smoking status, physical status, age at first pregnancy, and number of children (Table 1). No significant differences between groups were detected for total energy intake, total fat intake, saturated fatty-acid (SFA), mono-unsaturated fatty-acid (MUFA), and poly-unsaturated fatty-acid (PUFA) all of which are potential confounders during AR absorption (Table 1; ). We found significant differences between groups for rye and cereal fiber intakes (Table 1). These results were expected since groups were divided based on the level of rye intake. No difference between groups was observed for wheat intake or total fiber intake (Table 1). Finally, significant differences emerged between groups for plasma DHPPA, urinary DHPPA, urinary DHBA, and sum of urinary AR metabolites, but not for plasma DHBA or sum of plasma AR metabolites (Table 1).
The high rye intake group, compared with the medium and low rye intake groups, had a greater urinary DHPPA (p = 0.026 and p = 0.001, respectively), urinary DHBA (p = 0.042 and p = 0.001, respectively), and plasma DHPPA (p = 0.034 and p = 0.034, respectively).
|Variable||Low rye intake (n = 20)||Medium rye intake (n = 20)||High rye intake (n = 20)||p-values|
|Age (years)||47 ± 13||45 ± 15||49 ± 15||0.598|
|Weight (kg)||60 ± 11||61 ± 8||63 ± 6||0.648|
|Body mass index (kg/m²)||22 ± 3||23 ± 3||23 ± 3||0.549|
|Age at menopause (years)||50 ± 3||50 ± 1||49 ± 4||0.768|
|Age at menarche (years)||13 ± 1||13 ± 1||13 ± 1||0.576|
|Physically active (%)||55||50||50||0.935*|
|Age at first pregnancy (years)||26 ± 3||27 ± 5||25 ± 5||0.521|
|Number of children||1.9 ± 1.5||1.1 ± 1.3||1.5 ± 1.5||0.183|
|P-DHBA (nmol/L)P-DHPPA (nmol/L)||85 ± 5676 ± 37||97 ± 6989 ± 53||102 ± 45110 ± 43∆†||0.333**0.043**|
|U-DHBA (μmol/24h)||21 ± 8||26 ± 12||32 ± 9∆†||0.005**|
|U-DHPPA (μmol/24h)||32 ± 15||40 ± 26||48 ± 13∆†||0.001**|
|Sum P-AR metabolites (nmol/L)||157 ± 87||187 ± 121||210 ± 87||0.185|
|Sum U-AR metabolites (μmol/24h)||52 ± 23||66 ± 38||79 ± 22∆†||0.003**|
|Rye intake (g/d)||23 ± 9†||44 ± 4∆||68 ± 18∆||0.000|
|Wheat intake (g/d)||79 ± 30||79 ± 20||71 ± 36||0.615|
|Cereal fiber intake (g/d)||7.8 ± 2.3†||9.4 ± 1.6∆||11.9 ± 2.6∆†||0.000|
|Total fiber intake (g/d)||16 ± 7||19 ± 5||20 ± 5||0.156|
|Total kilocalorie intake (kcal/d)||1774 ± 281||1866 ± 285||1832 ± 410||0.676|
|Total fat intake (g/d)||76 ± 15||76 ± 15||72 ± 18||0.682|
|SFA (g/d)||36 ± 11||39 ± 9||38 ± 11||0.715|
|MUFA (g/d)||25 ± 5||24 ± 6||22 ± 6||0.293|
|PUFA (g/d)||10 ± 3||10 ± 4||9 ± 4||0.825|
Means ± SD. p < 0.05 = significantly different.* p-value obtained by Chi-square test. ** p-value obtained with log variables. ∆ p < 0.05; significantly different from low rye intake. † p < 0.05; significantly different from medium rye intake. Physically active = physical activity > 3 h/week; P = plasma; U = Urine; DHBA = 3,5-dihydroxybenzoic acid; DHPPA = 3-[3,5-dihydroxyphenyl]-1-propanoic acid; SFA = saturated fatty acid; MUFA = mono-unsaturated fatty acid; PUFA = poly unsaturated fatty acid.
Urinary DHBA correlated significantly and more strongly than plasma DHBA with rye intake (r = 0.524 vs. r = 0.299) and fiber intake (r = 0.443 vs. r = 0.331), Urinary DHPPA and plasma DHPPA correlated significantly with rye intake (r = 0.438 vs. r = 0.397) and total fiber intake (r = 0.390 vs. r = 0.366), even after adjustment for BMI and age (Table 2). We found that urinary AR metabolites and plasma DHPPA increased proportionally and significantly with the consumption of rye (Table 3; Figure 1). However, plasma DHBA did not significantly increase with greater rye intake (Table 3; Figure 1). In addition, the urinary AR metabolite ratio seemed relatively stable with different rye intakes but this was not the case with the plasma AR metabolite ratio (Table 3).
|Rye intake (g/d) with covariables||Rye intake (g/d) without covariables|
* p < 0.05.** p < 0.01.*** p < 0.001. P = plasma; U = urine; DHBA = 3,5-dihydroxybenzoic acid; DHPPA = 3-[3,5-dihydroxyphenyl]-1-propanoic acid.
|Rye intake groups||P-DHBA (nmol/L)||P-DHPPA (nmol/L)||P-DHBA/DHPPA (ratio)||U-DHBA (μmol/24h)||U-DHPPA (μmol/24h)||U-DHBA/DHPPA (ratio)|
|Medium (+21 g/d)||+14%||+17%||+18%||23%||25%||+1%|
|High group (+45 g/d)||+20%||+44%∆†||+25%||52%∆†||50%∆†||−6%|
P = plasma; U = urine; DHBA = 3,5-dihydroxybenozoic acid; DHPPA = 3-[3,5-dihydroxyphenyl]-1-propanoic acid. Number of subjects in each group = 20.∆ p < 0.05; significantly different from low rye intake.† p < 0.05; significantly different from medium rye intake.
We evaluated whether the amount of rye intake in a habitual diet would be related to the responsiveness of AR metabolites in urine and plasma similarly to in an interventional study . Responsiveness is a prerequisite for a biomarker . We allocated 60 women into three dose groups (reference dose 23 g/d vs. 44 g/d or 68 g/d of rye) and compared the response of AR metabolites relative to the amount of rye consumed. Compared with the reference dose, we observed that for an increase of 21 g/d and 45 g/d of rye, AR metabolites rose by 25% and 50%, respectively. Urinary AR metabolites were closely related to rye intake, with their levels increasing proportionally to the amount of rye consumed (Table 2, Table 3). However, plasma DHPPA responded much more strongly to rye intake in Finnish women. Our results confirmed those of Landberg et al. , who observed during their interventional study that 24-h urinary excretion of AR metabolites had a linear dose-response relation with plasma intact AR concentration. In addition, urinary metabolite excretion is known to correlate with plasma intact AR concentration. Finally, we found that responsiveness of DHPPA in plasma and urine is related to the amount of rye consumed. Interestingly, plasma DHPPA correlated more strongly with cereal fiber intake (r = 0.463; ) than plasma AR C21:0 (r = 0.416; ) or urinary DHBA (r = 0.372; ). In epidemiological studies, it is easier to obtain fasting blood samples than 24-h urine collections. Moreover, the half-life of plasma AR metabolites (mean ~12 h;) is longer than the half-life of intact plasma ARs (mean ~5 h, ). The method for analyzing plasma and urinary AR metabolites is more convenient, faster and requires less sample pre-treatment than the method for plasma intact ARs.
Our study is the first to show that AR metabolites, more specifically AR metabolites in urine and plasma DHPPA, have a good responsiveness to wheat and rye whole-grain cereal intake [14,19]. Thus, our results are in line with those of Landberg et al.  and confirm that AR metabolites, and specifically AR metabolites in urine, are a promising biomarker for rye and wheat cereal whole-grain intake. To be considered a dietary biomarker, a marker must be validated in experimental and observational studies investigating the dose-response relationships . However, further research is needed before concluding that ARs, and specifically AR metabolites, are strong dietary biomarkers [25,26].
ARs are absorbed in the upper gastrointestinal tract and incorporated into chylomicrons, which are distributed to the circulation through the lymphatic system [12,27], transported to the liver, and thereafter incorporated in HDL or VLDL or hypothetically through the enterohepatic circulation for urinary AR metabolites similarly to estrogen metabolites . The AR level in erythrocytes is correlated with the plasma AR concentration in the fasting blood sample and also follows the changes in whole-grain intake [27,28]. Longer AR homologs are more easily incorporated into the membrane . The metabolites are transported via the blood to the kidneys. DHPPA, which is a bigger molecule than DHBA, might not be taken up by the liver, and is probably directly excreted in bile and urine. This potential mechanism for both AR metabolites could explain the responsiveness difference in the AR metabolite ratio in plasma and urine. To support this hypothesis, a change has been shown in the elimination route after hepatic metabolism from urinary excretion to biliary excretion for tocopherols, which have some structural similarities to ARs [23,30]. Finally, we observed no difference between groups for the amount of fat intake. Different fat amounts could affect the intestinal absorption of such highly lipophilic micronutrients as ARs .
Our study has some limitations. It was carried out in Finnish women, who are known to consume a high daily amount of cereal fibers, rich in ARs, mainly from whole-grain rye and wheat . Finland and Denmark have the highest intake of ARs of all European countries. The estimated average daily intake of ARs is around 11 mg/d in the United Kingdom, as compared with 40 mg/d in Finland [12,31]. In our subjects, the amount of rye corresponds, in general, with the amount of cereal fiber intake (for each additional 20 g/d of rye intake, we observed an additional 2 g/d of cereal fiber intake, see Table 1). Thus, confirming our results in countries where rye is not the first source of cereal fiber, e.g., the US or the United Kingdom, would be a good idea. It is recognized that there are some inherent weaknesses of food frequency questionnaires [3,4]. However, a three-day dietary record has been demonstrated to be valid for estimating dietary intakes in adults. In addition, we collected the dietary data in two occasions which reduced the risk of error. Finally, if some misidentification of groups has been done by the subjects this would be true in each group. Moreover, further studies using spot urine (e.g., morning fasting urine sample) are needed to confirm that the responsiveness of urinary AR metabolites is equivalent to a day collection; for epidemiological studies, collecting spot urine would be easier than a 24-h urine collection.
Sixty women living in the Helsinki area were recruited. They were divided into three groups according to their rye intake: (1) low of rye intake: 23 ± 9 g/d (n = 20); (2) medium rye intake: 44 ± 4 g/d (n = 20), and (3) high rye intake: 68 ± 18 g/d (n = 20). Subjects with a history of cancer or other major diseases or using oral contraceptives, hormone replacement therapy, or antibiotics were excluded. All subjects agreed to consume their habitual diet throughout the study. Age, weight, height, body mass index (BMI: kg/m²), age at menarche, type of diet, number of children, menopausal status, smoking status, and physical activity level were recorded by a questionnaire during the screening visit. All subjects gave their informed consent and were initially interviewed by a doctor who disclosed the study plan. The research protocol was approved by the Ethics Committee of Helsinki University Central Hospital.
3.2. Data Collection
All subjects were studied for five days on two occasions with a six-month interval. The five-day food record was initiated two days before the three-day plasma and urine collections. The food records included at least one day on the weekend. Fasting blood samples were taken every morning on three consecutive days. After cooling to room temperature, blood samples were centrifuged and plasma was collected. Sodium azide (0.1%) and ascorbic acid (0.1%) were added, and samples were stored at 4 °C until the last collection day, when equal portions of each plasma sample were combined and stored at −20 °C until analyzed. The three-day urine was collected in plastic bottles containing 1 g of ascorbic acid per liter volume. Sodium azide (0.1%) was added, and the samples were stored at −20 °C until analysis. The premenopausal women collected the samples during the mid-follicular phase of their menstrual cycles (days 5–7).
3.3. Dietary Intake
All subjects agreed to maintain their habitual diet throughout the study. Each subject was provided with a letter balance and was instructed on how to complete the dietary records. A three-day dietary record has been demonstrated to be valid for estimating dietary intakes in adults without cognitive impairments . Dietary analyses were completed by a nutritionist using the Southgate tables for cereal fiber data , but otherwise using data produced by the manufacturers of the breads and other cereal products.
3.4. Urinary Alkylresorcinol Metabolites
The two urinary AR metabolites, DHPPA and DHBA, were analyzed by high-performance liquid chromatography (HPLC) with coulometric electrode array detection (CEAD; ESA Biosciences) as described by Koskela et al. . Briefly, to 100 µL of urine, we added the internal standard syringic acid in 10 µL of methanol. The sample was hydrolyzed overnight at 37 °C with an equal volume (100 µL) of hydrolysis solution containing 0.1 mol/L Na-acetate buffer, pH 5, 0.2 U/mL β-glucuronidase, and 2 U/mL sulfatase. After incubation, a 50-µL aliquot (equal to 25 µL of urine) was taken and 50 µL of methanol and 650 µL of HPLC mobile phase were added to the sample and the sample was analyzed for the two AR metabolites by HPLC-CEAD. The intra-assay CV was for DHBA 5.6% and for DHPPA 7.7%. The inter-assay CV was for DHBA 10.9% and for DHPPA 10.4%. The method is considered accurate, specific, and reproducible .
3.5. Plasma Alkylresorcinol Metabolites
The two plasma AR metabolites, DHPPA and DHBA, were analyzed by HPLC-CEAD as described by Koskela et al. . Briefly, to 100 µL of plasma, we added syringic acid as the internal standard. The enzymatic hydrolysis was carried out overnight at 37 °C. The sample was acidified to reach a pH of 3 and thereafter extracted three times with diethyl ether. The combined organic phases were evaporated to dryness. The sample was reconstituted in 50 µL of methanol, and 100 µL of HPLC mobile phase was added. The sample was filtered through a 0.2-µm Gelman GHP filter and analyzed with HPLC-CEAD . The intra-assay CV was for DHBA 4.2% and for DHPPA 3.8%. The inter-assay CV was for DHBA 7.4% and for DHPPA 10.7%. The method is considered accurate, specific, and reproducible .
3.6. Statistical Analysis
Normality of distribution was determined using the Kurtosis test. Data were log-transformed if abnormally distributed. The three groups (low, medium, and high) were compared by ANOVA using Bonneferoni post-hoc for all variables. Furthermore, we examined potential differences in responsiveness of plasma and urinary AR metabolites using parametric tests. Pearson´s and Partial (with age and BMI as covariables) correlations between urinary or plasma AR metabolites and rye intake were performed. P-values of ≤0.05 were considered statistically significant. Analyses were performed using SPSS 15.0 software (Chicago, IL).
We conclude that plasma DHPPA, and urinary DHBA and DHPPA appear to be strong and accurate biomarkers of whole-grain cereal fiber intake. In evaluating ARs as a biomarker of whole-grain wheat and rye intake, we earlier have shown that ARs (intact, urinary, and plasma metabolites) correlate with cereal fiber intake [14,19,22]. In this study, we observed the responsiveness of AR metabolites in Finnish women. Thus, studies carried out by Landberg et al. under intervention conditions [15,17,18,32] and our studies [11,14,16,19,27,33] support the idea that AR metabolites appear to be good dietary biomarkers. Further research is needed to confirm our results in larger and non-Nordic European populations where rye is not the first cereal fiber source. Finally, the kinetics of AR metabolites must be investigated to elucidate the difference in responsiveness between plasma and urinary AR metabolites in humans.
This study was supported by the Medical Research Council of the Academy of Finland, the Sigrid Jusélius Foundation, and Samfundet Folkhälsan. Mylène Aubertin-Leheudre was supported by the Canadian Institutes of Health Research (CIHR).
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Date: August 7, 2021
Time: 8:00 am - 12:00 pm
Location: PIncushion Mountain Trail System
Walk or run, youth and adults. Come celebrate our return to normal at Pincushion by participating in or watching the annual Fishermen’s Picnic Run at Pincushion. There are events for all ages and interests. The trails are beautiful, and it promises to be a festive day for all. The event is hosted by the North Superior Ski and Run Club at Pincushion.
You must pre-register on-line in order to participate. THERE IS NO RACE-DAY REGISTRATION. Deadline for on-line registration is Friday, August 6th at 6PM,
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BOOK LOVE MASISI
Originally from Port-Au-Prince, Haiti, Love Masisi lived in the US for many years and perfected her feminine drag skill there. A couple years back, she made the big move to Europe and currently resides in Amsterdam to snatch the drag scene overseas.
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She is a singer and has many years of experience as a theatre performer. Next to hosting, she is a talented musician, dancer and actress. She has graced our television sets with her presence in RTL’s ‘I Can See Your Voice’, ‘Makeup Your Mind’ and most recently of course as the breakout star of Dragrace Holland season 2. She is cast to appear in the new season of 'Queen of The Universe'.

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Sugar=Empty calories in most cases nowadays. The fact that it was added in the first place tells you that it was not necessary, and as Americans we have managed to find an excuse to add sugar into EVERYTHING. You’ve only got 4 days left! (Yay!) Take the time to cut all processed sugars out of your life and just see where it leads you. If you’re not sure about the sugar content of something, check the nutrition label. Keep in mind that some sugars are naturally-occurring, such as those in fruit and milk. But many packaged products contain processed sugars, which will likely be identified in the ingredient list as “sucrose”.
The point to this is simply to encourage you to satisfy your sweet tooth with a healthier option. The sugars that are naturally occurring in fruits are much kinder to your body than the one in an Oreo cookie. That being said, sugar is still sugar, so don’t go nuts. Eat 2 fruits today, and at the end of the day, see if you’ve eaten as much junk food as you normally do.
Sugar is often my biggest weakness when it comes to sticking to a diet. I can stop frying foods and I can drink more water. But I cannot pass up a tootsie roll that is staring me in the face. So that is your job today. No Candy. One day is enough to prove to yourself that it is possible.

domain: food


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Stocks To Watch: ITC, IndusInd Bank, Persistent Systems, Rail Vikas Nigam, Adani Enterprises, Glenmark Pharma
Stocks to watch before going into trade today.
Asian markets headed for a mixed open on Wednesday as investors assessed the path for monetary tightening and prepared for potential policy tweaks from the Bank of Japan.
At 6:04 a.m., the Singapore-traded SGX Nifty, an early indicator of India's benchmark Nifty 50, was up 0.25% to 18,122.
U.S. stocks struggled to rise as earnings outlook and Fed’s prospective plans weighed on investor sentiments. The S&P 500 closed in the red for the first time in five days, while Nasdaq 100 eked out gains, up for a seventh day.
Meanwhile, the yield on 10-year Treasuries advanced three basis points to 3.53%. Crude price fell 0.5%, while gold declined 0.6%. Bitcoin rose 0.3% to trade around the $21,200-level.
Indian benchmark indices closed higher after opening with steady gains, with 17 out of 20 sectoral indices compiled by BSE ending in green.
Rupee continued to fall against the U.S. dollar tracking recovery in the greenback and firm crude prices.
Overseas investors in Indian equities turned net buyers on Tuesday. Foreign portfolio investors mopped up equities worth Rs 211.06 crore, while domestic institutional investors bought stocks worth Rs 90.81 crore on Jan. 17.
Stocks To Watch
ITC: The company will acquire 100% stake of Sproutlife Foods for a cash consideration. Initially, Rs 255 crore will be invested to acquire 47.5% stake till March 2025.
Rail Vikas Nigam: The company has emerged as the lowest bidder for two projects by under Surat Metro Rail Project Phase-I and Ahmedabad Metro Rail Project Phase-II worth Rs 673.80 crore and 384.30 crore, respectively.
Adani Enterprises/Ashok Leyland: The company has signed an agreement with Ashok Leyland and Canada’s Ballard Power for a pilot project to develop and launch hydrogen fuel cell electric truck in 2023.
REC: The entire shareholding of WRSR Power Transmission with REC Power Development & Consultancy, a subsidiary of the company, has been transferred to Adani Transmission.
Glenmark Pharmaceuticals: The company will divest select brands and sub-brands from its dermatology segment for India and Nepal territories to Eris Oaknet Healthcare for Rs 340.48 crore.
Jammu & Kashmir Bank: The board will meet on Jan. 23 to consider raising Tier-I capital via employee stock purchase scheme.
Coforge: Life Insurance Corporation increased its stake in the company to 5.03% from 4.98%.
Adani Transmission: Operational Updates In Q3 FY23
Sales improved 4% YoY to 2,165 million units against 2,077 million units a year ago.
The company added 371 ckms to operational network.
Distribution loss improved to 5.34% in Q3 FY23, against 6.53% last year.
ICICI Prudential Q3 FY23 (Consolidated, YoY)
Revenue up 78% at Rs 17,535 crore Vs Rs 9,865 crore
VNB up 23.2% at Rs 1,710 crore Vs Rs 1,388 crore (nine months)
VNB margin at 32% Vs 27.1% (nine months)
Net profit fell 29% at Rs 221.5 crore Vs Rs 312 crore
ICICI Lombard Q3 FY23 (Consolidated, YoY)
Revenue up 13.18% YoY at Rs 4,362 crore Vs 3,854.14 crore (Bloomberg estimate: Rs 4,378.8 crore)
Gross direct premium income up 21% at Rs 16,048 crore Vs Rs 13,311 crore (nine months)
Return on average equity at 18.1% Vs 15.1% (nine months)
Net profit up 11% YoY at Rs 352.53 crore Vs Rs 317.53 crore (Bloomberg estimate: Rs 448 crore)
Delta Corp Q3 FY23 (Consolidated, QoQ)
Revenues up 1.26% at Rs 273.37 crore vs Rs 269.97 crore
EBITDA up 1.97% at Rs 102.32 crore vs Rs 100.34 crore
EBITDA margin at 37.43% vs 37.17%
Net profit up 24.28% at Rs 84.82 crore vs Rs 68.25 crore
Tata Investment Corporation Q3 FY23 (Consolidated, YoY)
Revenues down 26.11% at Rs 37.66 crore Vs Rs 50.97 crore
EBITDA down 30.15% at Rs 31.60 crore Vs Rs 45.23 crore
EBITDA margin at 83.91% Vs 88.74%
Net profit down 13.24% at Rs 34.53 crore Vs Rs 39.8 crore
Gulshan Polypols Q3 FY23 (Consolidated, YoY)
Revenue up 13.3% at Rs 331.62 crore Vs Rs 292.66 crore
EBITDA down 31.4% at Rs 24.18 crore Vs Rs 35.23 crore
EBITDA margin at 7.2% Vs 12%
Net profit down 37.8% at Rs 118.50 crore Vs Rs 190.50 crore
Tata Metaliks Q3 FY23 (Consolidated, YoY)
Revenue up 14.56% at Rs 790.23 crore Vs Rs 689.8 crore
EBITDA down 42.88% at Rs 38.74 crore Vs Rs 67.82 crore
EBITDA Margins at 4.9% Vs 9.83%
Net profit down 73.41% at Rs 9.48 crore Vs Rs 35.65 crore
Eris Lifesciences Q3 FY23 (Consolidated, YoY)
Revenue up 27.43% at Rs 423.26 crore Vs Rs 332.16 crore (Bloomberg estimate: Rs 445.93 crore)
EBITDA up 12.72% at Rs 137.2 crore Vs Rs 121.72 crore (Bloomberg estimate: 142.23 crore)
EBITDA margin at 32.42% Vs 36.65% (Bloomberg estimate: 31.9%)
Net profit up 1.1% at Rs 101.86 crore Vs Rs 100.77 crore (Bloomberg estimate: Rs 108 crore)
Shalby Q3 FY23 (Consolidated, QoQ)
Revenue up 0.33% at Rs 202.46 crore Vs Rs 201.8 crore (Bloomberg estimate: Rs 213.90 crore)
EBITDA down 9.08% at Rs 33.96 crore Vs Rs 37.35 crore
EBITDA margin at 16.77% Vs 18.51%
Net profit down 16.95% at Rs 15.29 crore Vs Rs 18.41 crore (Bloomberg estimate: Rs 20 crore)
Hathway Cable & Datacom Q3 FY23 (Consolidated, QoQ)
Revenues up 1.11% at Rs 478.45 crore Vs Rs 473.22 crore
EBITDA down 3.56% at Rs 2.44 crore Vs Rs 2.53 crore
EBITDA margin at 0.51% Vs 0.54%
Net profit down 4.9% at Rs 28.74 crore Vs Rs 30.22 crore
IndusInd Bank, Persistent Systems, Central Bank of India, Rallis India, Oracle Financial Services Software, CCL Products (India), Alok Industries, PSP Projects, Stylam Industries, Surya Roshni, Wendt (India)
Bajaj Finserv: Madhur Securities bought 1.45 lakh shares (0.09%), Rahul Securities bought 2.55 lakh shares (0.16%) and Rishab Family Trust sold 4 lakh shares (0.25%) at Rs 1,380 apiece.
V-Mart Retail: Amansa Holding bought 1.65 lakh shares (0.83%) at Rs 2,800 apiece.
BCL Industries: Kedia Fintrade bought 2 lakh shares (0.83%) and Rollon Investment sold 2 lakh shares (0.83%) at Rs 450 apiece
Samvardhana Motherson International: Sojitz Corporation sold 10.61 crore share (1.57%) at Rs 73.11 apiece.
Pledge Share Details
Ajanta Pharma: Promoter Aayush M Agrawal, trustee Aayush Agrawal Trust, revoked a pledge of 8.20 lakh shares on Jan. 12.
Ex-Date Bonus Issue: KPI Green Energy
Who’s Meeting Whom
Hindustan Aeronautics: To meet analysts and investors on Jan. 19.
Nifty January futures ended at 18,092.50, a premium of 150.75 points.
Nifty January futures fell 1.84% and 4,336 shares in Open Interest.
Nifty Bank January futures ended at 42,380, a premium of 78.75 points.
Nifty Bank January futures fell 5.37% and 4,603 shares in Open Interest.
Securities added to the ban period: Delta Corp, Gujarat Narmada Valley Fertilizers & Chemicals, Indiabulls Housing Finance, L&T Finance Holdings and Manappuram Finance
Securities removed from the ban period: Nil

domain: news


text:
Correction of an announcement according to Section 25a, para. 1 of the WpHG
[the German Securities Trading Act]
Correction of an announcement according to Section 25a of the WpHG [German Securities Trading Act]
Morgan Stanley, New York, USA has informed us on 6 June 2012 of the following correction to its notification of 15 May - which we published on 21 May 2012 - pursuant to Section 25a of the WpHG:
Due to an error in calculation, Münchener Rückversicherungs-Gesellschaft Aktiengesellschaft in München, Munich, was erroneously reported as exceeding the 5% threshold as at 11 May 2012 by Morgan Stanley & Co International Plc, Morgan Stanley UK Group, Morgan Stanley Group (Europe), Morgan Stanley International Limited, Morgan Stanley International Holdings Inc and Morgan Stanley. The notifications should be disregarded, and it is duly confirmed that the voting rights held by the above companies in Münchener Rückversicherungs-Gesellschaft Aktiengesellschaft in München pursuant to Section 25a WpHG did not exceeded the threshold of 5% as at 11 May 2012 and remains less than 5%, as at 6 June 2012.
Munich, 8 June 2012
The Board of Management

domain: economics


text:
Japanese company Topy Industries Ltd (Topy) has agreed to buy a 26 per cent stake in WIL Car Wheels Ltd (WCWL), a wholly owned subsidiary of wheels manufacturerWheels India Ltd(WIL) for an undisclosed amount, as per a stock market disclosure.
Continue reading this story with a subscription to DealStreetAsia.
Unlock your competitive advantage in a rapidly evolving scape. Our packages come with exclusive access to archives, content, data, discount on summit tickets & more. Be a part of our growing community now.

domain: finance


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Nwaoboshi, a senator representing Delta North, was arraigned in 2018, by the Economic and Financial Crimes Commission on two counts of money laundering and fraud.
Browsing: Senator Peter Nwaoboshi
The Interim Management Committee of the NDDC, led Prof. Kemebradikumo Pondei, had appeared before the National Assembly Joint Committee on NDDC for the 2019 Budget performance and also presentation of the 2020 Budget proposal for consideration on Tuesday.
He is to remain behind bars until April 27, the court ruled.
The senator representing Delta North Senatorial District was arraigned on two counts of money laundering and fraud alongside two companies — Golden Touch Construction Project Limited and Suiming Electrical Limited
The charges were slammed on them by the Economic and Financial Crimes Commission
The EFCC spokesman, Wilson Uwujaren, confirmed this to the newspaper on the telephone on Monday.
In a press statement on Sunday, Minister of Information and Culture, Alhaji Lai Mohammed, said the list of alleged looters released earlier was based on verifiable facts, including the amount involved, the date the amount in question was collected and from where it was taken
The House of Representatives has last week began a fresh process for the passage into law of the Electoral Act (amendment) bill, 2018
The Police Public Relations Officer in the state, Andrew Aniamaka, said this in a statement on Tuesday in Asaba.
The EFCC alleged that Nwaoboshi laundered part of N1.5 billion which he fraudulently obtained from Delta State through a company known as Suiming Nigeria Ltd.
The court’s order was sequel to an ex-parte application filed by the Economic and Financial Crimes Commission
Uduaghan, who stated this in a Facebook post on Tuesday, asked those involved to “stop it”
The Chairman of Senate Committee on Niger Delta, Senator Peter Nwaoboshi, at the resumption investigative hearing lamented that the objectives of Presidential Amnesty Programme have been compromised
Nwaoboshi said those who have run away with money meant for the development of the Niger Delta would be held accountable, adding that the Senate Committee was determined to help the NDDC recover all funds due to it statutorily
The Chairman of the Senate Committee probing the issue, Senator Peter Nwaoboshi, while briefing newsmen disclosed that the amount due for payment to the NDDC by the NLNG and the Ecological Fund Office, which they allegedly refused to pay for over 16 years, is colossal

domain: law


Spatio-temporal Characteristics of Air-sea Momentum Fluxes Based on Two Coastal Towers
Published: 9 May 2023| Version 1 | DOI: 10.17632/ymkmbrc4mh.1
This is the momentum flux and surface wave datasets in the article.
Steps to reproduce
This is processed by MATLAB softrare. The figures in the article can be reproduced according to the data of different variables.
First Institute of Oceanography


This book is a comprehensive social history of how the London bus has worked in, and for, the capital for the last century and a half.
It discusses the design,development and operations of buses in the city and its surrounding countryside and considers how the bus has served Londoners from all over the world and shaped London.
Contributions from a number of recognised authorities on bus history,complement beautiful images from the London Transport Museum' archives and other private collections.
Omnibus celebrates the rich and diverse story of how city, suburban and country life have all been made easier by the London bus, its operating staff and excellent design.
Throughout this story the message is clear, every journey matters.


Roughly 1.6 million Americans don’t have hot and cold running water, a bathtub or shower or a working flush toilet, nor do they have clean water that’s safe to drink. DIGDEEP is one of the only organizations in the United States working to change that. And now, Ferguson is too.
Ferguson has signed on as the organization’s first corporate partner, and together, they will help millions of their neighbors in need through Community Plumbing Challenges (CPCs). CPCs bring together a unique team of volunteer tradespeople and organizations from all over the United States to deliver running water and safe wastewater disposal for families situated in a particular area. During the CPCs, residents are also trained to maintain their new plumbing systems.
“When we think of access to clean water and proper sanitation, we tend only to see it as an issue abroad,” said Kevin Murphy, CEO. “We have an opportunity to really invest our products, resources and expertise to tackle a very-solvable social issue.”
DIGDEEP focuses its work in places without clean, running water or basic plumbing. It empowers American communities to build and manage low-cost systems that bring safe, hot and cold water into homes, schools and community centers.
DIGDEEP’s water projects are community-led and designed to improve human rights standards like health and economic development measurably. In places that already have access to water, DIGDEEP designs experiences that help Americans form a deep and lasting connection to the water that is often taken for granted.
Ferguson's partnership with DIGDEEP aligns with its Ferguson Cares mission to ensure every household in the United States has access to clean water and with its focus on the United Nations’ Sustainable Development Goal to ensure sustainable management of water and sanitation for all. Those who would like to be involved can email Ferguson Cares or visit DIGDEEP’s website.


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Shari Arison talks with Nader Botto, a senior cardiovascular physician and inventor of the Energetic Rinse method, about his Integrative Medicine approach that combines conventional and holistic medicine to treat a wide spectrum of disorders, by connecting between body, spirit, and soul.
Shari Arison explores the meeting-point between medicine and spirituality with Dr. Nader, a senior cardiovascular physician who has always searched for the meaning of life and the essence of the human being.
As a cardiologist, Dr. Nader shares how the heart has taught him about the laws of the universe. He has worked to integrate physicality and the psyche, developing an integrative treatment system that accurately maps-out the correlation between physical diseases and psychological conflicts. He stresses there is a learning process that psychological conflicts are meant to ignite within us, but are often stopped due to the physical event. Shari Arison discusses with him the importance of searching for our role in life, and how giving of ourselves to others is the path to finding our place in the world – by serving others with love.

domain: library


NFL Expert Picks - Week 2
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The fact remains that it's the defense that keeps New York winning. The front seven, in particular, consistently thwarts opposing running games. Lev Bell presents a completely different kind of monster than Isaiah Crowell , Jeremy Hill or any of the running backs New York has faced this season save for maybe Ezekiel Elliott , though that was the rookie's first NFL game.
One other interesting note on the G-Men: They've been escaping by the hair of their chinny chin chin, earning all but one of their wins by seven points or less. Do you give them credit for doing what it takes? Or are they a middling team canvased by an record? Well, maybe not by today's standards, but certainly not a defensive struggle. For Washington, the key will be not letting drives fail on the opponent's side of the field, something that happened too much in Dallas.
Which is why the Redskins piled up over yards of offense with no turnovers and lost. Arizona isn't much different in this regard: Bruce Arian's offense is ninth in yards per game , yet the Cardinals are 20th in points per game. As far as the Washington offense is concerned, Kirk Cousins has been hell on wheels recently on throws of plus yards: A perfect passer rating is Put in laymen's terms, he's lit on those deep throws.
Sorry, been on Instagram and Snapchat too much lately. The defense, which is allowing 24 points per game, is improving. Yet, this is one long road trip across the country for a team coming off of its most emotional win in years. While I don't see Jameis Winston losing focus, it wouldn't surprise me if Tampa came out flat in the first quarter.
The key matchup will be Philip Rivers ' pass protection versus a suddenly legit we think Tampa pass rush. Was last week's pummeling of Russell Wilson a product of the Bucs' front seven, or a talent-optional Seahawks offensive line? Considering Rivers has been sacked 26 times this year, the Bucs' pass rush might not need to be legit.
Melvin Gordon , meanwhile, is a different beast entirely from the RB-by-committee Tampa saw last Sunday. Gordon will be the difference. The Seahawks are an embarrassed football team. Well, at least the offense anyway. The Sunday night game should be every bit as physical as the Chiefs-Broncos classic last Sunday night , albeit with a hair less scoring. Carolina must make the tough catches for Cam Newton , who was under siege from a Mack truck late in Oakland.
Ditto Russell Wilson , who, one week after getting sacked over and over again in Tampa, faces a defense that is tied with the Seahawks for most sacks in the NFC. That's why this feels like a Thomas Rawls contest, finally. Seattle definitely would be catching a break if Luke Kuechly were to miss another game, although A. Klein has fared well as Kuechly's replacement. Don't be surprised if Wilson takes advantage, as the fifth-year pro always picks it up during the winter months.
It looks like Andrew Luck will suit up for the Colts on Monday -- and he should benefit from facing a weak Jets secondary. Ryan Fitzpatrick will get the nod from Todd Bowles , despite the disappointing ending in the loss to the Patriots. Matt Forte hit the skids in that game, but will find the Colts ' front seven far more forgiving. Indy's run defense allows opposing running back's a robust 4. That should keep Fitzpatrick in favorable situations -- so, in theory, he could go a second straight week without an interception.
Gang Green is this season when they've lost the turnover battle. Don't think the lovable Jets lose either battle this week. Ezekiel Elliott will find this Vikings front almost as challenging to run on as the Ravens' unit was , but the Minnesota defense needs help from a punchless offense that refuses to go downfield. If safety Barry Church is out for the Cowboys again, that should at least help Sam Bradford test the waters.
The Vikings quarterback has impressed with a Super cool, except he never attempts passes that travel at least 15 yards past the line of scrimmage any more. I've followed Mike Zimmer's career since he was a defensive assistant on the early-'90s Cowboys teams. He's always been highly thought of in league circles -- thus, the respect he's receiving from the masses now is hardly a surprise. Just hope that he's back on the sideline fully healthy sooner than later. You have my pick for Thursday night, but be sure to make yours, as well.
NFL Week 13 game picks: Steelers top Giants; Falcons nip Chiefs. Kirk Cousins is putting up strong numbers 3, yards, second in the NFL , yet is wildly inconsistent from series to series. Dak Prescott would envy that right now. The Bills have managed to beat the Patriots twice in the last four seasons and five meetings That suspension is over.
Two more bubble teams in their respective conferences. Would you be all that surprised if this was an NFC title game preview? Even the Titans likely are surprised to see themselves in first place this late in the season; they struggled too much against the Colts last week, and Marcus Mariota has suddenly turned into a pick machine. But their chance has arrived, and stumbling against a Texans team that misses Deshaun Watson desperately is not an option.
Predicting how entertaining a game will be is harder and more foolhardy than picking who wins, but circumstances indicate that this is the most unwatchable game of the weekend.
The four quarterbacks likely in play: Their seasons are in the toilet for legit reasons. When the Jaguars and Colts last met, in October in Indy, the Jaguars got 10 sacks and pitched a shutout.


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AlzheimersNet is your resource to memory care in Victoria, BC. Memory care facilities offer housing and care for older adults with Alzheimer's disease and other kinds of dementia. Memory care enables seniors with memory impairment to stay as active and engaged as they possibly can, while living in a dignified, comfortable and secure environment. Our local Senior Living Advisors have local expertise in dementia care in Victoria, BC and nearby cities. After an initial assessment, your advisor will prepare a list of memory care facilities that fit your loved one's essential requirements for care and living preferences, as well as your family's finances.Memory Care Costs in Victoria, BC
Price varies widely depending on location, care required, size of the resident's living space and the level of luxury at the community. The price of memory care in Victoria ranges from $4,740 to $6,450 a month.
Memory Care Costs in Nearby Cities* The costs above represent the AVERAGE monthly cost of memory care for a one person bedroom in that city.
Facts about Victoria
The official website for the city of Victoria is http://www.victoria.ca/.
Victoria is represented by MP Murray Rankin, MLAs Lisa Helps, Governing body Victoria City Council, and Mayor Carole James , Rob Fleming , Maurine Karagianis.
Victoria is the capital city of British Columbia, Canada, and is located on the southern tip of Vancouver Island off Canada's Pacific coast. The city has a population of about 80,017, while the metropolitan area of Greater Victoria, has a population of 344,615, making it the 15th most populous Canadian urban region.Victoria is about 100 kilometres (62 miles) from BC's largest city of Vancouver on the mainland. The city is about 100 kilometres (62 miles) from Seattle by airplane, ferry, or the Victoria Clipper passenger-only ferry which operates daily, year round between Seattle and Victoria and 40 kilometres (25 miles) from Port Angeles, Washington, by ferry Coho across the Strait of Juan de Fuca.Named after Queen Victoria of the United Kingdom and, at the time, British North America, Victoria is one of the oldest cities in the Pacific Northwest, with British settlement beginning in 1843. The city has retained a large number of its historic buildings, in particular its two most famous landmarks, Legislative buildings,(finished in 1897 and home of the Legislative Assembly of British Columbia) and the Empress hotel (opened in 1908). The city's Chinatown is the second oldest in North America after San Francisco's. The region's Coast Salish First Nations peoples established communities in the area long before non-native settlement, possibly several thousand years earlier, which had large populations at the time of European exploration. Victoria, like many Vancouver Island communities, continues to have a sizeable First Nations presence, composed of peoples from all over Vancouver Island and beyond.Known as the "The Garden City", Victoria is an attractive city and a popular tourism destination with a thriving technology sector that has risen to be its largest revenue-generating private industry. Victoria is in the top twenty of world cities for quality-of-life, according to Numbeo. The city has a large non-local student population, who come to attend the University of Victoria, Camosun College, Royal Roads University, the Victoria College of Art, the Sooke Schools International Programme and the Canadian College of Performing Arts. Victoria is very popular with boaters with its beautiful and rugged shorelines and beaches. Victoria is also popular with retirees, who come to enjoy the temperate and usually snow-free climate of the area as well as the usually relaxed pace of the city.

domain: geography


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- Obama not worried about Ebola at upcoming African summit in D.C.
- Obama: ‘We tortured some folks’ after 9/11
- Obama administration asked whole D.C. Circuit to take on major Obamacare case
- Mark Levin: Topple GOP leadership or country will ‘unravel’
- Massachusetts to let police chief deny gun buys to those deemed unfit
- John Kerry condemns attack on Israeli soldiers, kidnapping
- U.S. starts to evacuate American Ebola patients from West Africa: Report
- Geraldo slammed as ‘dummy’ for backing Clinton’s bin Laden claim
- Israeli spokesman: No need to debate who broke the cease-fire
- 35 Palestinians killed; Israeli officer missing
EDITORIAL: A lesson from the street
A policeman’s unhappy lot is to take criticism, like the rest of us
Question of the Day
Posting public information isn’t a crime, nor is taking a photograph of a public official conducting business on a public street. Nevertheless, Taylor Hardy, a journalism student, must appear in court Thursday in Boston to explain why he recorded a Boston police sergeant reacting violently to his filming of cops apparently engaged in the people’s business on a public street.
When the four-minute video, taken on a hot summer day, began attracting thousands of Internet viewers, Mr. Hardy, like a good student, called the Boston Police Department’s official spokesman, Angelene Richardson, for comment. In the interests of full disclosure, he posted their conversation on YouTube. Mr. Hardy was charged with wiretapping.
Now the story gets even more interesting. Carlos Miller, a blogger 1,500 miles away in Miami, saw the video and posted a comment on his own website. “Maybe we can call or email [Ms.] Richardson,” wrote Mr. Miller, “to persuade her to drop the charges against [Mr.] Hardy, considering she should assume all her conversations with reporters are on the record unless otherwise stated.” He posted her office telephone number. This appears to be a polite and straightforward expression of speech protected by the First Amendment, but the Boston police nevertheless charged Mr. Miller with “witness intimidation,” a felony that carries a maximum penalty of 10 years in state prison and a fine of $5,000.
The blogger did not intimidate Ms. Richardson. She was not told to “avoid court if you know what’s good for you.” Everyone has a right to call her in her official capacity to tell her what he thinks. She doesn’t have to pay attention to what anyone tells her, or even to listen.
If the Boston Police Department is looking for intimidation, it may be on the video that started all this. It shows a plainclothes police sergeant bumping into Mr. Hardy, saying, “You touch me again and I will lock you up for assault and battery on a police officer.”
Public officials, including police officers, cannot be allowed to use their offices to insulate themselves from scrutiny or criticism, even harsh criticism. The law protects the public from being hurt by the bad guys, even with badges. From this distance, neither Mr. Hardy nor Mr. Miller appears to have done anything but bruise an ego or two. The real offense appears to be the abuse of the judicial system to intimidate. We hope the court explains this to the misbehaving cops, and why they can’t be allowed to do that.
About the Author
- Take a first look at The Washington Times' new dynamic website
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Procedural changes impede the chamber's traditional deliberative function
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- House GOP resurrects border bill, predicts successful Friday vote
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domain: politics


text:
We start off today’s Radioactivity discussing the Freddie Gray case, particularly a claim circulating around conservative blogs that Gray had a previous spinal cord injury that might have contributed to his death after falling into a coma in the back of a police van. [The Washington Post reported last week] that that claim of a preexisting condition is not true.
Then we look at the minimum wage for tipped restaurant employees, which is $2.13 at the federal level and $5.03 in Florida. we listen to an interview from the Travis Smiley Show (which you can tune into on our HD3 channel) with Suru Jayaraman, co-founder/director of Restaurant Opportunities Centers United, an advocacy group for food service workers that is calling for a fair minimum wage for service workers that is the same for non-tipped employees. Jayaraman goes into the history of the service wage that is rooted in slavery and the ongoing efforts to lift wages within the restaurant industry, which are among the lowest in the country.
We also talk with Eddie Vale, Director of American Bridge 21st Century Foundation, a progressive political advocacy group that recently released a report on the influence that the conservative Koch Brothers have on politics in Florida. The report looks at Koch influence on major political figures such as Gov. Rick Scott, former Gov. Jeb Bush, and presidential hopeful Marco Rubio.


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Online slot games are increasingly complex as developers strive to create a game that is exciting and engaging for their players. This has resulted in the introduction of symbols such as wilds and scatters which, whilst they may sound a bit off-putting at first glance, can actually be hugely beneficial to your gameplay.
These new symbols add a whole new dimension to your game, by increasing your chances of winning. As well as this, the addition of wilds and scatters also makes your wins more frequent and larger. This is one of the key reasons why more and more people are choosing to play slots online than ever before.
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Spatial patterns of fetal loss and infant death in an arsenic-affected area in Bangladesh
2010 (English)In: International Journal of Health Geographics, ISSN 1476-072X, Vol. 9, 53- p.Article in journal (Refereed) Published
Background: Arsenic exposure in pregnancy is associated with adverse pregnancy outcome and infant mortality. Knowledge of the spatial characteristics of the outcomes and their possible link to arsenic exposure are important for planning effective mitigation activities. The aim of this study was to identify spatial and spatiotemporal clustering of fetal loss and infant death, and spatial relationships between high and low clusters of fetal loss and infant death rates and high and low clusters of arsenic concentrations in tube-well water used for drinking.Methods: Pregnant women from Matlab, Bangladesh, who used tube-well water for drinking while pregnant between 1991 and 2000, were included in this study. In total 29,134 pregnancies were identified. A spatial scan test was used to identify unique non-random spatial and spatiotemporal clusters of fetal loss and infant death using a retrospective spatial and spatiotemporal permutation and Poisson probability models.Results: Two significant clusters of fetal loss and infant death were identified and these clusters remained stable after adjustment for covariates. One cluster of higher rates of fetal loss and infant death was in the vicinity of the Meghna River, and the other cluster of lower rates was in the center of Matlab. The average concentration of arsenic in the water differed between these clusters (319 μg/L for the high cluster and 174 μg/L for the low cluster). The spatial patterns of arsenic concentrations in tube-well water were found to be linked with the adverse pregnancy outcome clusters. In the spatiotemporal analysis, only one high fetal loss and infant death cluster was identified in the same high cluster area obtained from purely spatial analysis. However, the cluster was no longer significant after adjustment for the covariates.Conclusion: The finding of this study suggests that given the geographical variation in tube-well water contamination, higher fetal loss and infant deaths were observed in the areas of higher arsenic concentrations in groundwater. This illustrates a possible link between arsenic contamination in tube-well water and adverse pregnancy outcome. Thus, these areas should be considered a priority in arsenic mitigation programs.
Place, publisher, year, edition, pages
2010. Vol. 9, 53- p.
arsenic exposure, drinking-water, fetal loss, infant death, spatial clustering, Bangladesh
Public Health, Global Health, Social Medicine and Epidemiology Geology
Research subject Epidemiology; Earth Science with specialization in Environmental Analysis; International Health
IdentifiersURN: urn:nbn:se:uu:diva-121780DOI: 10.1186/1476-072X-9-53ISI: 000284357300001PubMedID: 20977746OAI: oai:DiVA.org:uu-121780DiVA: diva2:306600

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St. Lucia was my last stop on a whirlwind nine-country Caribbean tour that was done in just nine days, including travel! I was pretty wiped out by the time I arrived that Saturday night at 5:45PM. I had just one night in St. Lucia, so I had to make the most of it. It was home tomorrow!
RAMBLIN’ TIP: St. Lucia is one of the only Caribbean islands I’ve experienced that has two major airports: UVF in the south and SLU at the top. Make sure you know which airport you’re flying in and out of, and plan accordingly. My first itinerary had me flying into SLU and out of UVF. I hear the cross-country drive to the opposite airport is very long and super hilly. They also offer helicopter rides to and from each airport.
Luckily for this quick one-night stopover, Coconut Bay was just a few minutes away from UVF. The resort was gorgeous, sprawling, and not too many people there! My room was awesome (complete with rose petals on the bed) and very comfortable. I headed down for dinner and had some wonderful BBQ, served outside by the pool. There was live entertainment on the stage: that night was themed “Western,” and it was pretty cool to see and hear Caribbean folk jammin’ out to country music on stage–how fun!
After dinner I strolled the grounds and even relaxed in a hammock under the stars, taking in the breeze and stars above.
It was up early the next morning to enjoy Coconut Bay before my 2:35PM flight back to Miami. The sea was choppy that day, so I hung out at the pools and had some fun on the slides. The property was huge, and I lost track of how many pools there were. Every time I turned a corner on their immaculately landscaped grounds, another pool! They had a lazy river too!
Like most of the islands on this tour, my time in St. Lucia was way too quick. If you’re flying into UVF, I definitely recommend a stay at Coconut Bay. There was so much of St. Lucia I didn’t get to see…I’ll have to come back soon!This entry was posted in Caribbean

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ASTM B163 B167 ASME SB163 SB167 N06600 Inconel 600 DIN 17751 2.4816 is a nickel-chromium alloy used for applications that require corrosion and high temperature resistance. This nickel alloy was designed for service temperatures from cryogenic to elevated temperatures in
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ASTM B166 specification covers Inconel 600 and Inconel 601 with UNS N06601 and N06600 in the form of hot-finished and cold-worked rounds, squares, hexagons, rectangles, and cold-worked wire. Siddhagiri Metals and Tubes is a renowned supplier, manufacturer, exporter of ASTM B166 Round bars.
Alloy 600 is machinable in both the hot worked and annealed conditions. Because considerable heat is generated in machining this alloy, high-speed steel, cast nonferrous or cemented carbide tools should be used. The tools should be kept sharp.
An ISO 9001:2008 Certified Company, Aesteiron Steel Pipes also stock a wide range of Inconel 600 seamless Tube, Inconel Pipe, Inconel Tube, Inconel 600 Tube, Inconel 601 Tube, Inconel 625 Tube, Inconel 800 Tube, Inconel 825 Tube, Hastelloy C22 Tube, hastelloy C276 Tube, Inconel 718 Tube, Monel 400 Tube & many more special steel grades tubing.
Monel 400 is a nickel-copper alloy (about 67% Ni 23% Cu) that is resistant to sea water and steam at high temperatures as well as to salt and caustic solutions. Alloy 400 is a solid solution alloy that can only be hardened by cold working. Some results are removed in response to a notice of local law requirement. For more information, please see here.
Translate this pageAlliez 600 la haute température non magnétique de tuyauterie d'UNS N06600 Inconel 600® Description. L'alliage 600 est un alliage à hautes températures non magnétique et basé sur nickel possédant une excellente combinaison de caractère réalisable de haute résistance, chaud et froid, et de résistance à la forme ordinaire de corrosion.
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Nickel Alloy 600 pipe, also known as Inconel 600 Pipe, is an extremely versatile nickel-chromium alloy capable of resisting oxidation in temperatures up to 2000 ºF (1093 ºC).Inconel 600 Seamless Pipe is a non-magnetic nickel-chromium-iron high temperature alloy with an excellent combination of high strength, hot and cold workability and high corrosion resistance.
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NAS 600 (UNS N06600), comparable to Inconel ® 600 Alloy. NAS 600 (NCF 600, UNS N06600) is a nickel-chromium alloy that provides excellent resistance to oxidation at high temperatures. It is also commonly used as a corrosion resistant alloy due to its resistance against a range of acids and alkalis.
Translate this pageLa combinazione di alte aggiunte del cromo e dell'alluminio a RA 602 risultati di CA in una resistenza al superiore di spolveramento del metallo alle leghe quali RA330, la lega 600, la lega 601 e la lega 800H/AT. È suggerito per saldare il RA 602 CA con RA 602 materiali di consumo della saldatura di CA. Some results are removed in response to a notice of local law requirement. For more information, please see here.
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Turkey’s ‘Blue Homeland’ doctrine on the Mediterranean takes shape in Libya
Turkish President Recep Tayyip Erdogan gambled big in Libya and won big – so far. This victory portends important changes in the politics of the Mediterranean, for Turkey has succeeded not only in demonstrating its determination to become the dominant player in the Eastern Mediterranean, but also in showcasing its military prowess and wherewithal. The latter might precipitate a deeper conflict and crisis in the region, extending north toward Greece.
Erdogan threw his support behind the UN-recognized Government of National Accord (GNA) against General Khalifa Haftar’s Libyan National Army (LNA), which had besieged the GNA’s capital, Tripoli. Haftar suffered a humiliating defeat as Turkish drones, troops, navy vessels and some 10,000 Syrian fighters transported by Ankara to Libya stopped him in his tracks and then forced him to abandon bases and territory. A last-minute call for a ceasefire by Egyptian President Abdel Fattah El-Sisi was rejected by the victorious GNA, which has set its aims at capturing other towns, including the critical port city of Sirte.
Indirectly, this was also a defeat for the countries that had backed Haftar: Egypt, the UAE and Russia. The UAE had contributed military equipment and the Russians non-state mercenary forces.
Turkey’s Libya expedition has to be seen from two perspectives. First, the GNA concluded a deal with Ankara that delineated their respective Exclusive Economic Zones (EEZ) in such a way that it divides the Mediterranean Sea into two sections. Turkey’s purpose is to hinder efforts by Egypt, Cyprus, Israel and Greece to export natural gas, either through a pipeline or on LNG vessels, to Europe. Turkey has aggressively interfered with efforts by these to drill for gas. Ankara claims that most of the waters around Cyprus actually belong to Turkey or to the Turkish Republic of Northern Cyprus, a country recognized only by Turkey.
However, more important than simply preventing Eastern Mediterranean gas exports is the underlying strategy driving this push against Haftar. From the moment he assumed power in 2003, Erdogan has striven to elevate Turkey’s international role to that of a regional, if not global, power. Initially, his strategy was one of “zero problems with neighbors,” which served to emphasize Turkey’s soft power. The primary driver, however, was the desire for Turkey to assume a hegemonic position over the Middle East. This policy foundered and was essentially buried by the Arab Spring.
What has replaced it is a more aggressive and militarized posture that takes the fight to perceived enemies. That could mean anyone and everyone, since Turks tend to see most countries as a threat, even if they are allies. Before Erdogan, Ankara pursued defensive strategies. Under Erdogan, Turkey has intervened in Syria against the Assad regime and again against the Syrian Kurds who are allied with the United States. Turkish troops and their Syrian Islamist allies have occupied two Kurdish areas in northern Syria with the ultimate intention of constructing a Kurdish-free buffer zone. The only reason it remains uncompleted is because a small American force is still there working with the Syrian Kurd-led Syrian Democratic Forces. Even so, and against advice from his aides, at no point has President Donald Trump opposed Erdogan’s moves in Syria.
In the Mediterranean, however, it is clear that Erdogan has now adopted a strategy developed by arch-nationalist army officers, called the “Blue Homeland.” As a first step, this new doctrine envisages the domination of the Aegean, of most of the Mediterranean and of the Black Sea. To this end, Turkey has invested in expanding both the size and sophistication of its navy.
Turkish victories in Syria and Libya have been made possible by Washington and Europe’s unwillingness to stand up to Erdogan, which only feeds his sense of invincibility. This week, he launched airstrikes against Turkish Kurds and their affiliated groups in Iraq. Erdogan might follow up these moves with a land invasion of northern Iraq.
There are two real dangers ahead. The first is a possible confrontation with Greece which, like Turkey, has been a member of Nato since 1952. The Blue Homeland doctrine makes it clear that Turkey does not recognize the post-World War I arrangements over the Aegean. Turkey claims many Greek islands and Greece’s EEZ. There have been hints about drilling for gas near the Greek island of Crete. Flushed with confidence after his victories in Syria and Libya, Erdogan may well decide this is a good time to challenge Greece, especially as such an exploit would play well at home.
The second danger lies in Libya. Turkey makes no secret of wanting to establish a naval and an airbase on Libyan territory. Along with any attempt to expand the GNA-controlled zone by moving toward Sirte, these bases could trigger a more forceful Egyptian reaction, possibly supported by Algeria and even the Russians.
The Europeans, especially the French, are alarmed at the presence of a large contingent of Syrian Islamist fighters brought to Libya by Turkey. The memory of jihadi terrorism in France – not to mention the continued struggle to contain similar insurgencies in West Africa – has provoked strong criticism of Erdogan from President Emmanuel Macron.
A new crisis, therefore, is brewing and unless Washington starts paying attention, it could mutate into yet more, wholly avoidable, long-term discord.
Henri J Barkey is the Cohen Professor of International Relations at Lehigh University and an adjunct senior fellow for Middle East studies at the Council of Foreign Relations, and a former member of the US State Department’s Policy Planning Staff. This article was contributed to Kathimerini English Edition by the Syndication Bureau.


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Despite the publicity he's been getting lately, it might be easy to forget that Justin Bieber does a lot for his fans.
The heartthrob's Twitter followers received a gentle reminder of that side of him when he tweeted a touching tribute to a young boy named Jake Schafer who died back in August of neuroblastoma.
"Heard little Jake is up in heaven. The world lost a great kid but I'm grateful I got to meet him. RIP Jake," Bieber wrote along with a link to a Youtube video of the two of them playing hockey together.
Bieber met his fellow Canadian in 2011 as part of Shafer's wish via the Children's Wish Foundation and the two hit the ice and played with the Toronto Maple Leafs.


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TOXIC FRACKING BRINE SPRAYED ON ROADS BY DOT IN WEST VIRGINIA
"Photos of wet pavement Rt. 20 & 41 mid day 12-18-16 from the ole Pioneer Inn at Glade Creek to top of Curtin Mt. ... What the hey you say .., well here's the big Deal. This water was spread on the road by a WVDOH tanker truck & the water happens to be a product of gas well drilling & fracking operations & contains more lethal poisonous chemicals than most of us could ever name & some that the oil ...& gas won't tell us about. It does contain large amounts of salts which does aid in the melting of snow & ice on the roads but where do all those poisons go when the snow melts & the rains come folks. Very easy answer which you don't wanna hear ... The poisons flush into the streams & seep into the ground waters both of which are sources of your drinking water. Do you want to drink that stuff that is being poured on our highways??"
Feeling lucky? Maybe you will NOT end up behind one of these trucks, like we did recently. My nose, throat and eyes were burning and I could SMELL chemicals, despite having the vehicle's air conditioning set to recirculate. Our windscreen wipers were running the whole time. The whole car was covered. The residue dried white. I was fully aware that this residue is radioactive, and simply breathing dust could, at the least, set you up for lung cancer from alpha and gamma ray emitters.
So, you ask, what kind of pollutants are we talking about? Benzene, Bromides, Radium.. and heavy metals .. just for starters!
From Pennsylvania to Ohio - the radiation issue alone is an eye-opener
"Radium in one sample of Marcellus shale wastewater, also called brine, that Pennsylvania officials collected in 2009 was 3,609 times more radioactive than a federal safety limit for drinking water. It was 300 times higher than a Nuclear Regulatory Commission limit for industrial discharges to water.
The December 2011 study, compiled by the U.S. Geological Survey, also found that the median levels of radium in brine from Marcellus shale wells was more than three times higher than brine collected from conventional oil and gas wells.
“These are very, very high concentrations of radium compared to other oil and gas brines,” said Mark Engle, a U.S. Geological Survey research geologist and co-author of the report.
State law bans radioactive shale-well sand and sludge from Ohio landfills. However, brine can be sent down any of Ohio’s 171 active disposal wells regardless of how much radium it contains. Michael Snee, the Ohio Department of Health’s radiation-protection chief, said that’s the safest place for brine.“Injection wells are almost the perfect solution for that disposal issue,” Snee said.
However, environmental advocates say the Geological Survey’s report intensifies their fears of surface spills and leaks to groundwater.
“It’s an alarm bell in the night that we better get serious about testing the material in the Utica shale right here in Ohio,” said Jack Shaner, an Ohio Environmental Council lobbyist.
Shaner and others said the study shows that state officials should look at what’s bubbling out of Ohio’s shale wells.
Radiation is yet another wrinkle in the ongoing debate over “fracking,” a process that sends millions of gallons of water, sand and chemicals down wells to shatter shale and free trapped oil and gas. Thousands of Marcellus shale wells have been drilled in Pennsylvania. Of the 12.2 million barrels of brine injected into Ohio disposal wells last year, 53 percent came from Pennsylvania and West Virginia.
A similar drilling and fracking boom is expected in Ohio’s Utica shale. Engle said the Marcellus shale absorbs uranium from ancient saltwater trapped within the rock layer. The decaying uranium then leaks radium into the water. As the wells continue to produce oil and gas, Engle said the brine becomes saltier and more radioactive.
For its study, the Geological Survey examined 52 samples of Marcellus shale brine collected from wells in New York and Pennsylvania from 2009 through 2011.In 37 of the samples, radioactivity from radium-226 and radium-228 was at least 242 times higher than the drinking-water standard and at least 20 times higher than the industrial standard.
That included a sample collected Dec. 21, 2009, in Tioga County, Pa., that was 3,609 times higher than the drinking water standard and 300 times higher than the industrial.
The U.S. Geological Survey’s Ohio office wants to study radium and other contents of Utica brine. “We want to understand these natural formation fluids, what’s in the ground before any drilling occurred,” said Ralph Haefner, the survey’s groundwater-studies chief.
Snee said there’s no need for the state to test Utica brine because disposal wells are safe. He said shale wastes trucked to landfills pose a bigger threat to groundwater.
In May, the health department told American Landfill in Stark County that two truckloads of waste sand from two Greene County, Pa., wells must instead go to a hazardous-waste landfill.
Required lab tests showed radium at levels 36 times higher than the state’s safety standard. Some critics say they worry that Ohio municipalities will spray shale brine on roadways in winter to combat ice. There are no restrictions against using shale-well brine on Ohio roadways."
There is also NO restriction on spraying brine on West Virginia's roadways.
LINK - http://www.dispatch.com/content/stories/local/2012/09/03/gas-well-waste-full-of-radium.html


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