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Massive Disneyland Attraction Database
Above: The Abuland Railroad attraction at midday
March 8, 1962
Avg. queue length:
The Abuland Railroad's antique radiation-powered handcar will take you on a grand sort-of-circle tour facing away from the parking lot. Before stops in random lands, the handcar will take you away from the perplexing Carefree Canyon and Primieval Form thingies, in which you can hear preserved animals and unfeathered robotic creatures from scores of decades in the past.
- If traveling with teens that you want to annoy, experience this attraction only after a pledge of silence.
Guest Policies and Information
- For your avoideance of liability, you should be free from '80s haircuts or chest, brain, viral, or romantic problems or other conditions that could lessen your enjoyment of this experiment.
- This attraction closes at park closing.
- Hades was once reported riding this attraction.
- Walt Disney had a handcar of his own in the back yard of his home. He called it the Oogiewood Pacific.
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NUCB21–83 has been recently reported as an anorexigenic and anti-hyperglycemic peptide. Here we report that NUCB21–83 promotes osteogenesis. It was found after two months of once-a-day intravenous injection of NUCB21–83, bone mineral density of femora and lumbar vertebrae were increased in ovariectomized rats. NUCB21–83 also increased the alkaline phosphatase activity and promoted mineralization in mouse MC3T3-E1 preosteoblastic cell line. When either both Arg60 and Arg63 or Ser72 were mutated to Ala, the pro-osteogenic activity was completely lost, indicating that these residues are structurally important for its biological function. Furthermore, it encumbered osteoclastic differentiation of RAW 264.7 macrophage. It also excluded any possibility of the effect caused by contaminants or experimental faults, and demonstrated that the pro-osteogenic activity observed was a specific effect of NUCB21–83 itself. These findings warranted that further studies on NUCB21–83 would be valuable for the treatment of bone metabolic diseases especially for osteoporosis.
Citation: Li R, Wu Q, Zhao Y, Jin W, Yuan X, Wu X, et al. (2013) The Novel Pro-Osteogenic Activity of NUCB21–83. PLoS ONE 8(4): e61619. https://doi.org/10.1371/journal.pone.0061619
Editor: Yvette Tache, University of California Los Angeles, United States of America
Received: April 17, 2012; Accepted: March 14, 2013; Published: April 15, 2013
Copyright: © 2013 Li et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding: The authors have no support or funding to report.
Competing interests: Several authors have an affiliation to Landing Laboratories, which is a nonprofit research organization. This affiliation does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.
Osteoporosis is a skeletal disease characterized by loss of bone mass and strength that leads to fractures . It is a public health threat due to the potentially disastrous results  and high cumulative rate of fractures. It is estimated that more than 100 million people worldwide are at risk for the disorder  and fracture rates seem to be rising ceaselessly.
Osteoporosis is mainly caused by an imbalance between osteoblast-mediated bone formation and osteoclast-mediated bone resorption , . A number of medicines have been developed to treat osteoporosis, mainly including (1) bone resorption inhibitors, which prevent excessive bone loss by reducing the osteoclast formation and activity; (2) bone formation accelerators, which increase bone mineral density and bone mass by stimulating the osteoblast activity; (3) bone mineralization drugs, which stimulate new bone mineralization.
NUCB21–83 is also called nesfatin-1. It has recently been identified as a satiety molecule associated with melanocortin signaling system detectable in central neurons  as well as an anti-hyperglycemic peptide when it is given intravenously . NUCB21–83 was also reported to have a role in the response to stress and mediation of anxiety- and/or fear-related behaviors in rats , . The expression of NUCB21–83 was induced by troglitazone, an activator of peroxisome proliferator-activated receptor-γ (PPAR-γ) . The activation of PPAR-γ was recognized to cause loss of bone . Therefore, we have curiously examined the effect of NUCB1–83 on bone metabolism.
Since ovariectomized (OVX) rat is a classic animal model for postmenopausal osteoporosis, we have intravenously (i.v.) injected NUCB21–83 once a day to OVX rats continuously for two months to observe the changes in bone mineral density (BMD). In addition, we have also evaluated both the promoting effect of NUCB21–83 on osteoblastogenesis in the mouse MC3T3-E1 preosteoblastic cell line and its inhibitory effect on osteoclastogenesis in murine RAW 264.7 macrophages, as well as its presence in osteoblasts and osteoclasts.
Materials and Methods
Materials and Reagents
Recombinant human bone morphogenetic protein-2 (rhBMP-2) was prepared by our laboratory , as well as recombinant NUCB21–83 and its mutants. No endotoxin was detected in the preparation of recombinant NUCB21–83 using a Limulus Amoebocyte Lysate test kit. The BCA protein assay kit was purchased from Pierce (Rockford, IL, USA). The ALP activity kit and the commercial calcium kit were obtained from Nanjing Jiancheng Biological Institute (Nanjing, China). Leukocyte acid phosphatase kit was purchased from Sigma-Aldrich (St. Louis, MO). MC3T3-E1 cells and RAW 264.7 cells were obtained from CCTCC (Wuhan, China).
Twenty 3-month-old virgin female Sprague-Dawley rats were obtained from the Experimental Animal Centre of Qinglongshan (Nanjing, China). All rats were housed at 25°C with a 12-h light/dark cycle with lab chow and water available ad libitum. All procedures in animal experiments were conducted with the approval from the Animal Study Committee of Institute of Molecular Medicine, Nanjing University (Study Number: IMM022-10). Rats were ovariectomized or sham-operated. Some animals were euthanized at 16 weeks after surgery, and femora and lumbar vertebrae were dissected free of soft tissues and stored in 75% ethanol for the BMD assay. The ovariectomized rats were then divided into two groups and intravenously injected with saline or NUCB21–83 (50 nmol) once a day. After 60 days, their femora and lumbar vertebrae were collected for the BMD assay as described below.
BMD were measured for femora of both sides and lumbar vertebrae using a dual energy X-ray absorptiometry (QDR 2000 Plus; Histologic, Bedford, MA, USA).
MC3T3-E1 Cell Cultures
For ALP Assay, MC3T3-E1 cells were seeded at a density of 2×105 cells/30-mm well in α-modified minimal essential medium (α-MEM, GIBCO, Grand Island, NY, USA) containing 10% fetal bovine serum (FBS, GIBCO) supplemented with 100 U/mL penicillin (North China Pharmaceutical, Shijiazhuang, China) and 100 U/mL streptomycin (Lu-Kang, Jining, China) in 5% CO2 at 37°C. Twenty-four hours after plating, the adherent cells were treated with 1 µg/mL of rhBMP-2. Simultaneously, test samples were added to the cells respectively. The conditioned medium was changed on the third day after the addition of the test samples.
On the sixth day, the cells were harvested by trypsinization and suspended in 1 mL of phosphate buffered saline (PBS). The cell suspensions were sonicated in ice bath for 1 min for protein determination and the ALP assay.
For mineralization assay, MC3T3-E1 cells were cultured in 10 cm dishes at an initial density of 1×105 cells/cm2 in α-MEM containing 10% FBS and 100 U/mL penicillin and 100 U/mL streptomycin in 5% CO2 at 37°C. To support differentiation, 10 mM β-glycerophosphate (Sinopham Chemical Reagent, Shanghai, China) and 50 µg/mL ascorbic acid (Sinopham Chemical Reagent) were added to the cultures. 50 nM NUCB21–83 was added into the conditioned medium in experimental group and the medium was then changed twice a week. The control and experimental groups were cultured for 15 days.
Alkaline Phosphatase (ALP) Assay
After sonication, the alkaline phosphatase activity of the lysates was measured spectrophotometrically using the ALP activity kit. Protein concentration of the lysates was determined by BCA protein assay.
Where P is the ALP activity, Mphe is the mass of phenol which can be measured directly and Mpro is total protein mass of the sample after digestion and sonication.
MC3T3-E1 cells were cultured for 15 days and the mineralized matrix was stained by Alizarin-red staining method. After 15 days, cells were washed with PBS and fixed in ice cold 95% ethanol for at least 1 hour. Ethanol was removed, and cells were rinsed with deionized water and stained with 1% (w/v) Alizarin red (Sinopham Chemical Reagent, Shanghai) for 30 minutes at 37°C. Stained cells were further rinsed three times with deionized water and washed for 15 minutes in PBS with rotation to reduce nonspecific Alizarin red stain. Stained cultures were photographed. An appropriate amount of lysate was collected for calcium measurement using the commercial calcium kit.
RAW 264.7 Cell Culture and Osteoclast Differentiation
RAW 264.7 cells were cultured in DMEM (GIBCO, Grand Island, NY, USA) containing 10% FBS, 2 mM glutamine, 100 U/mL penicillin and 100 U/mL streptomycin in 5% CO2 at 37°C. For the osteoclast differentiation, cells were seeded on 24-well plates and grown to about 90% confluence in α-MEM containing 50 ng/mL NF-kappaB ligand (RANKL) (Sigma-Aldrich, St. Louis, MO). 50 nM NUCB21–83 was added into the culture medium in experimental group and the medium were changed every 2 days. The control and experimental groups were cultured for 5 days.
TRAP (Tartrate-Resistant Acid Phosphatase) Assay
After 5 days of differentiation, RAW 264.7 cells were fixed with 4% formalin for 10 min and stained using leukocyte acid phosphatase kit (Sigma-Aldrich, St. Louis, MO), according to the manufacturer’s instructions. TRAP-positive multinucleated cells were visualized under light microscopy.
For measuring the TRAP activity, cells were fixed with 4% formalin for 10 min and 95% ethanol for 1 min. Subsequently, the dried cells were incubated in 10 mM citrate buffer (pH 4.6) containing 10 mM sodium tratrate (Sigma-Aldrich St. Louis, MO) and 5 mM p-nitrophenylphosphate (New England BioLabs, Beverly, MA, USA ). After incubation for 1 h, the reaction mixtures were transferred into new well plates containing an equal volume of 0.1 N NaOH. Absorbance was measured atλ = 405 nm and the TRAP activity was expressed as percent of that of untreated control.
RT-PCR and Quantification of NUCB21–83 mRNA in Osteoblasts and Osteoclasts
Total RNA was extracted from MC3T3-E1 cells and differentiated RAW 264.7 cells using the Trizol RNA isolation reagent (Takara, Japan). RNA purity was checked by optical density (OD) absorption ratio (OD260nm/OD280nm) using a UV-1700 spectrophotometer (SHIMADZU, Japan). One microgram total RNA was added to the RT reaction using AMV reverse transcriptase and an oligo (deoxythymidine) 12–18 primer (Takara, Japan) according to the manufacturer’s protocol. The sequences for the sense and antisense primers (respectively) were:
mouse NUCB21–83 sense, 5′-ACAAAATGCAGAGGACGATA-3′ and
mouse beta-actin sense, 5′-AGGCCAACCGTGAAAAGATG-3′ and
SYBR Green real-time PCR was performed on a CFX96™ Real-Time System (Bio-rad, USA) using the primers listed above. The preparations lacking cDNA templates were set as negative controls for the reactions. Protocol conditions consisted of denaturation of 95°C for 300 sec, followed by 45 cycles of 95°C for 15 sec, 60°C for 60 sec, followed by melting-curve analysis. For analysis, expression of NUCB21–83 was normalized against the expression of the housekeeping gene beta-actin.
All the results were expressed as the mean±SEM. Statistical significance was evaluated by Student’s t-test in BMD assay, calcium measurement and TRAP activity measurement. Statistical significance of ALP assay was determined by one-way analysis of variance (ANOVA) followed by Dunnett's test. A value of P<0.05 was considered to be significant. Statistical analyses were done using GraphPad Prism 5.
A Significant Reduction in BMD in OVX Rats
BMD of femora and lumbar vertebrae in OVX rats were significantly lower than those in the sham-operated controls at 16 weeks after surgery (Fig. 1A). It suggested that the osteoporosis model was established for the study of the effect of NUCB21–83 on bone metabolism.
(A) BMD in OVX and sham-operated groups. Three-month-old virgin female Sprague-Dawley rats were ovariectomized or sham-operated. They were euthanized at 16 weeks after surgery, and their femora and lumbar vertebrae were dissected free of soft tissues and stored in 75% ethanol for the BMD assay. (B) BMD in different experimental groups after 60-day continuous administration. The ovariectomized rats were divided into two groups and intravenously injected with saline or NUCB21–83 (50 nmol) once a day. After 60 days, their femora and lumbar vertebrae were collected for the BMD assay. Data represented the mean±SEM(*P<0.05). Number of bone samples used is showed within the parentheses.
The Intravenous Injection of NUCB21–83 Increased BMD in OVX Rats
It was encouraging to notice that BMD of femora and lumbar vertebrae in the NUCB21–83-injected group were higher than those in the control group (Fig. 1B). After 60-day once-per-day administration, BMD of lumbar vertebrae increased about 10% in the NUCB21–83-injected group, which showed significant difference from that in the control group. BMD of femora increased about 5% in the experimental group, while the difference of femoral BMD between the two groups was statistically insignificant. No significant difference was observed in body weight as well as any noticeable side effects during the 60-day administration of NUCB1–83.
NUCB21–83 Significantly Increased the ALP Activity of MC3T3-E1 at the Presence of rhBMP-2
In order to investigate the dose-responsive effect of NUCB21–83 on ALP activity of MC3T3-E1 cells, different concentrations of the peptide were added to the conditioned medium containing rhBMP-2 (1 µg/mL). It was demonstrated that NUCB21–83 significantly increased the ALP activity at the concentration of 10 nmol/mL (P<0.01) (Fig. 2, Bar 4). When the concentration of NUCB21–83 was less than 10 nmol/mL, it is linearly correlated to the ALP activity. However, the ALP activity seemed to be independent of NUCB21–83 concentrations above 10 nmol/mL (Fig. 2).
MC3T3-E1 cells were treated with test samples for six days in the presence of rhBMP-2 (1 µg/mL). Data represented the mean±SEM. Number of samples used is showed within the parentheses. Statistical analysis according to one-way ANOVA was followed by Dunnett's test (**P<0.01).
Next, 10 nmol/mL of NUCB21–83 as well as its mutants were tested to investigate their effects on ALP activity in MC3T3-E1 cells in the presence of 1 µg/mL of rhBMP-2. It was found that 1 µg/mL rhBMP-2 significantly improved the ALP activity of MC3T3-E1 cells (Fig. 3, Bar 2). In the presence of rhBMP-2, NUCB21–83 further increased the ALP activity (Fig. 3, Bar 3), while NUCB21–83(Arg60/Arg63→Ala) and NUCB21–83(Ser72→Ala) lost this promoting effect (Fig. 3, Bar 4, 5). It suggested that Arg60/Arg63 and Ser72 were structurally important for the pro-osteogenic activity of NUCB21–83. These two mutants also served as negative controls, indicating that the promoting activity was a specific effect of NUCB21–83 itself.
MC3T3-E1 cells were treated with test samples for six days in the presence of rhBMP-2 (1 µg/mL). The concentrations of NUCB21–83 and its mutants were 10 nmol/mL. Data represented the mean±SEM. Number of samples used is showed within the parentheses. Statistical analysis according to one-way ANOVA was followed by Dunnett's test for BMP-2 vs. test samples (**P<0.01, ***P<0.001).
NUCB21–83 Promoted Mineralization of MC3T3-E1
MC3T3-E1 cells were cultured for 15 days with or without NUCB21–83 and the mineralized matrices were stained by Alizarin-red staining method (A) NUCB21–83 (B) control group just with conditional medium (C) The mineralized nodules were observed by microscope (magnification 100×).
MC3T3-E1 cells were cultured for 15 days with or without NUCB21–83 and lysates were collected for calcium measurement using the commercial calcium kit. Data represented the mean±SEM(**P<0.01). Number of samples used is showed within the parentheses.
NUCB21–83 Decreased Osteoclastogenesis of RAW 264.7 Stimulated by RANKL
It was found that stimulation with RANKL for 5 days enhanced the number of TRAP-positive multinucleated cells and TRAP activity in differentiated RAW 264.7 cells. When cells were incubated with 50 nM NUCB21–83, the osteoclastogenesis was reduced (Fig. 6, 7).
RAW 264.7 cells were cultured in the presence of RANKL (50 ng/mL) for 5 days with or without NUCB21–83 and stained for TRAP using leukocyte acid phosphatase kit. TRAP-positive multinucleated cells were visualized under light microscopy. (A,B) control group just with α-MEM (C,D) RANKL (E,F) RANKL and NUCB21–83. B, D, F were taken at 1000× magnification.
RAW 264.7 cells were cultured in the presence of RANKL (50 ng/mL) for 5 days with or without NUCB21–83. The cells were fixed and incubated in 10 mM citrate buffer (pH 4.6) containing 10 mM sodium tratrate and 5 mM p-nitrophenylphosphate for 1 h followed by transferring into new well plates containing an equal volume of 0.1 N NaOH. TRAP activity was measured at λ = 405 nm and expressed as percent of that of untreated control. Data represented the mean±SEM(*P<0.05). Number of samples used is showed within the parentheses.
NUCB21–83 mRNA Expressed in Osteoblast and Osteoclast
It was found that significant expression of NUCB21–83 mRNA was shown in MC3T3-E1 cells and differentiated RAW264.7 cells (Fig. 8). The negative control demonstrated the base-line result.
The precise quantitative data were obtained by using Real-Time Quantitative PCR. The results were normalized to beta-actin, which served as a control to verify the amount of samples. Data represented the mean±SEM. Number of samples used is showed within the parentheses.
The nucleobindins, NUCB1 and NUCB2, are homologous calcium and DNA binding proteins. It was reported that secreted extracellular NUCB1 might contribute in modulating the matrix maturation in bone with unknown mechanisms . NUCB21–83 was originally identified as an anorexigenic factor in hypothalamus which was recently reported to be anti-hyperglycemic . However, it has not been reported to affect bone metabolism. In our experiments, the intravenous administration of NUCB21–83 was found for the first time to increase BMD of femora and lumbar vertebrae in OVX rats.
Mouse MC3T3-E1 preosteoblastic cell line was derived from calvaria of newborn mice . It has been widely applied in the investigation of mechanism underlying osteoblast differentiation as it epitomizes osteogenic differentiation and maturation in vitro. ALP is a representative marker for osteoblastic differentiation . We discovered that NUCB21–83 dramatically increased the ALP activity in MC3T3-E1 in the presence of rhBMP-2. Moreover, it increased the mineralization of MC3T3-E1. These results confirmed the promotion effect of NUCB21–83 on differentiation and mineralization of osteoblasts. Meanwhile, the two mutants of NUCB21–83 showed the negative results, indicating the structural importance of Arg60/Arg63 or Ser72. These inactive mutants also excluded any possibility of the effect caused by contaminants or experimental faults, and demonstrated that the promoting effect observed was specifically due to NUCB21–83 itself.
Worthy to be noted, the promotion effect of NUCB21–83 on osteoblastic differentiation was found to be dependent on rhBMP-2, since NUCB21–83 itself had no direct effect on the ALP activity in the absence of rhBMP-2 (data not shown). In contrast, NUCB21–83 could improve mineralization with no addition of rhBMP-2. Additionally, the expression of NUCB21–83 was induced by troglitazone, an activator of peroxisome proliferator-activated receptor-γ (PPAR-γ). The activation of PPAR-γ was recognized to cause loss of bone. Therefore, the pro-osteogenic activity of NUCB21–83 could also be related to PPAR mediated signaling. We presume that NUCB21–83 plays differently in the different phases of osteoblast biology, which needs confirmation by further research.
Osteoclasts are bone-resorbing cells that differentiate from macrophage precursors in response to RANKL. TRAP is a important cytochemical marker of osteoclast function . In our experiments, we noticed that NUCB21–83 reduced formation of TRAP-positive multinucleated cells and decreased the TRAP activity in RANKL-treated RAW 264.7 cells. These results confirmed the inhibitory effect of NUCB21–83 on osteoclastogenesis of murine RAW 264.7 macrophages.
Taken together, NUCB21–83 promotes differentiation and mineralization of osteoblasts in vivo and in vitro, as well as inhibits osteoclast differentiation, indicating its important roles in metabolic control of bone. It is warranted that further studies on NUCB21–83 would be valuable for the treatment of bone metabolic diseases especially for osteoporosis.
Conceived and designed the experiments: RL QW FB JNL. Performed the experiments: RL QW YZ WJ XY XW YT FB. Analyzed the data: RL QW FB JNL. Contributed reagents/materials/analysis tools: YT JZ XT. Wrote the paper: RL QW JNL.
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- 3. Melton LJ III, Johnell O, Lau E, Mautalen CA, Seeman E (2004) Osteoporosis and the global competition for health care resources. J Bone Miner Res 19: 1055–1058.
- 4. Raisz LG (2005) Pathogenesis of osteoporosis. Concepts, conflicts, and prospects. J Clin Invest 115: 3318–3325.
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- 7. Su YJ, Zhang J, Tang YC, Bi F, Liu JN (2010) The novel function of nesfatin-1: Anti-hyperglycemia. Biochem Biophys Res Commun 391: 1039–1042.
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Wednesday, August 12, 2009
For SOME reason I only have the energy to copy/paste quotes for blog posts. But these quotes explain my past three days brilliantly.
“There is nothing more dreadful than the habit of doubt. Doubt separates people. It is a poison that disintegrates friendships and breaks up pleasant relations. It is a thorn that irritates and hurts; it is a sword that kills.” --Buddha

domain: literature


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domain: library


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This is my newest submission to Stampotique. Hope Carol love it. She is the best. Make sure you purchase these stamps and many more from her site.
All Stamps from Stampotique
"Merry Fairy", "Shoot for the Moon", "Hand", and "Hold onto your dreams"
List of Inks from Stewart Superior
The Embosser, Palette "Noir Black", "Violet Varnish,
Filigree Embossing Powder in both "Burnished Rose" and "White"
Palette Stamp and Stick Glue Refill "White"
Memories Mists Classic Metallic "Teal"
Memories Mists "Mango"
Ranger's Alcohol Ink: Stream, Wild Plum, Meadow and inking tools (see video on my site)
Metal Foil from the hardware store - located in the roofing section - called "flashing"
Dry embossing tool
scissor, adhesive, pop-dot, card stock, tranparence,
1) Stamp "Hold on to your dreams" on back side (sticker side) of Metal foil using "Noir Black" ink - trace hand and moon only with embossing tool (see video - Metal embossing). Apply Alcohol Ink to foil side (see video - Alcohol Ink). Cut hand out - set aside
2) Stamp Merry Fairy onto cream card stock using "the Embosser" and Filigree "White" embossing powder. Stamp Merry Fairy again onto transparency using Palette "noir black" ink - remember to heat set - use low setting on your embossing gun. On back of transparence stamped image color wings only using Silk "Fuchsia" - then place a small amount of Silk "fuchsia on to your teflon sheet and add a small amount of water to lighten the color. Color the skirt of "Merry Fairy". cut out wings and shirt. Adhere onto Full Merry Fairy. What a great idea with the Silk ink - add water and get the shade you want. More for your money!
3) Using Memories Mists - "Teal" and "Mango" watercolor techinique (see video - Memories Mist Watercolor) and color her hair and socks.
4) Stamp "Shoot for the Moon" onto cream cardstock and emboss using Filigree "Burnished rose" cut out into a square. Ink all edges using Palette "Violet varnish"
5) I had a Chip board Heart to use - but you could just punch or die cut out a heart from Chip board for youself. I used naked chip board, I applied Palette "stamp and stick glue refill" onto the chip board using a paint brush, heated with my embossing gun and applies "Metal leaf in Copper"
6) cut Purple Cardstock into 4" x 8" - in right hand corner, stamp "hand" using Palette "Violet Varnish". Ink all edge in "Violet Varnish"
7) Cut darker Purple cardstock into 8 1/2" x 9" - Score at 4 1/2" to make a card that is 8 1/2" x 4 1/2". Ink all edge in "Violet Varnish"
8) Adhere "Shoot for the Moon" over the "Hand", add "Merry Fairy". I used a pop-dot to adhere foil Hand. Adhere Heart in the hand. You card is complete.
Hope you enjoy this one. :-)

domain: design


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Income investors are increasingly endangered by U.S. monetary policies that keep interest rates at zero and drive asset prices to nosebleed levels.
Thus, we need to look all over the world for assets that pay decent returns and aren’t too expensive.
Emerging market shares fit this bill.[ad#Google Adsense 336×280-IA]And while they have their downsides, I’d argue that in today’s environment they represent a better risk-return balance than the shares of companies in the United States, Europe, or Japan.
The major advantage of emerging markets is that they tend to grow faster than developed markets.
The International Monetary Fund projects that the real gross domestic product (GDP) of advanced economies will grow by 2% in 2015 and 2.2% in 2016, while emerging markets will see growth of 4% in 2015 and 4.5% in 2016.
And that’s during a period when many emerging markets have suffered badly from the price decline in commodities and energy.
At a price-to-earnings (P/E) ratio of about 20, you’re paying too much for too little growth in the United States and other advanced economies.
Meanwhile, in emerging markets you’re generally paying lower multiples and getting more growth.
Emerging Market Arbitrage
There’s one simple reason for this disparity: arbitrage between emerging market labor markets and those of the West.
Before 1800, there weren’t vast differences in wealth between different parts of the world. For example, medieval China was richer than medieval Europe.
However, the Industrial Revolution enabled Europe and the United States to gain immensely in wealth, while the primitive transportation and communication of those times prevented the wealth from spreading rapidly to the rest of the world.
Japan and the Far East caught up in the 1960s and 1970s, but the real revolution has come with modern telecommunications and the internet, which have enabled poor countries to join global supply chains.
This has caused a continual arbitrage between advanced country and emerging market wage rates, where the differential between the two tends to narrow over time.
The trend has also been exacerbated by foolish policies in the West.
Zero interest rates have narrowed the capital cost differential between rich and poor countries and encouraged investment in the latter, while the scourge of excess regulation has blighted rich economies.
Of course, emerging markets do have their disadvantages.
For starters, they tend to be less reliably run than Western countries – though in the past few years, the average emerging market’s fiscal and monetary policies have been sounder than most Western counterparts.
As far as political risks, they tend to balance out.
On the one hand you have an apparently well-run Malaysia that gets involved in a multi-billion dollar bribery scandal, as well as a resource-wealthy Venezuela that descends into a socialist dictatorship.
On the other hand, there’s Argentina, which may suddenly be electing a sensible government after a decade of socialism.
Similarly, Colombia is making steady progress both economically and against its FARC guerilla problem.
Meanwhile, the silliness of many Western governments’ reactions to the 2008 financial crisis suggests the political risks are only moderately less in rich countries.
Take Your Pick
With faster growth, lower prices, and overall global trends favoring them, emerging markets should certainly be home for some of your money.
There are several exchange-traded funds (ETFs) specializing in emerging market dividend investments, any of which would be suitable for a U.S.-based income investor.
The WisdomTree Emerging Markets High-Dividend ETF (DEM) seeks to match the Wisdom Tree Emerging Markets High Dividend Index. It’s a $1.5 billion fund with a yield of 5.4% and a 0.64% expense ratio.
Next there’s the SPDR S&P Emerging Markets Dividend ETF (EDIV), a $298 million fund seeking to match the S&P Emerging Markets Dividend Index. It yields 5.3% and has an expense ratio of 0.59%.
Finally, there’s the iShares Emerging Market Dividend ETF (DVYE), a $158 million fund seeking to match the Dow Jones Emerging Markets Select Dividend Index. This one yields 6% and has a 0.68% expense ratio.
As you see, all three of these ETFs have higher yields than commonly found in developed country funds today, and they don’t suffer from the “eating your capital” problem of many domestic high-yield opportunities.
In today’s market, it’s madness not to consider them.
Source: Wall Street Daily

domain: news


Background: Disease surveillance systems capable of producing accurate real-time and short-term forecasts can help public health officials design timely public health interventions to mitigate the effects of disease outbreaks in affected populations. In France, existing clinic-based disease surveillance systems produce gastroenteritis activity information that lags real time by 1 to 3 weeks. This temporal data gap prevents public health officials from having a timely epidemiological characterization of this disease at any point in time and thus leads to the design of interventions that do not take into consideration the most recent changes in dynamics.
Objective: The goal of this study was to evaluate the feasibility of using internet search query trends and electronic health records to predict acute gastroenteritis (AG) incidence rates in near real time, at the national and regional scales, and for long-term forecasts (up to 10 weeks).
Methods: We present 2 different approaches (linear and nonlinear) that produce real-time estimates, short-term forecasts, and long-term forecasts of AG activity at 2 different spatial scales in France (national and regional). Both approaches leverage disparate data sources that include disease-related internet search activity, electronic health record data, and historical disease activity.
Results: Our results suggest that all data sources contribute to improving gastroenteritis surveillance for long-term forecasts with the prominent predictive power of historical data owing to the strong seasonal dynamics of this disease.
Conclusions: The methods we developed could help reduce the impact of the AG peak by making it possible to anticipate increased activity by up to 10 weeks.
Keywords: acute gastroenteritis; digital data; forecasting; infectious disease; machine learning; machine learning in public health; modeling; modeling disease outbreaks; public health.
©Canelle Poirier, Guillaume Bouzillé, Valérie Bertaud, Marc Cuggia, Mauricio Santillana, Audrey Lavenu. Originally published in JMIR Public Health and Surveillance (https://publichealth.jmir.org), 31.01.2023.


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The new 2018-19 Annual Catalog was unveiled to demonstrators this past weekend. This year’s catalog announced an exciting new change…a Color Revamp! Stampin’ Up! ink pads needed to be redesigned and improved, so this was a perfect time to bring out some fresh and trendy colors. You will love these new colors!
2018-2020 NEW IN COLORS (coming June 1)
NEW COLORS (coming June 1)
Click HERE for printable Color Revamp Summary
Due to NEW colors, that means we will be saying “good-bye”to OLD colors. Stampin’ Up! is retiring 17 colors. Below are the colors that are retiring. Right now, all the cardstock, ribbons, ink refills, stamp pads, and markers are WHILE SUPPLIES LAST! So make sure you order what you want ASAP. These products are known to sell out fast!
To see all retired products and to shop now, click HERE.
This is what all the colors will look like as of June 1st.
Very Exciting! Let me know if you have any questions.

domain: hobby


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Ecuador was an amazing trip in the midst of a pandemic...
Dec 31 - Jan 9, 2021
Ecuador was an amazing trip in the midst of a pandemic and an uncertain time within the world. It was a much needed vacation, and not one time did we feel unsafe or at risk due to covid. Extra precautions were taken, and everything went off without a hitch. From volcanoes, to hiking, to city experiences, Amazon adventures and more, there is nothing I would change about our trip.
"Fresh Eddie" our tour guide was one of the highlights for us! He graciously accepted our nickname given to him by me and my significant other and truly went out of his way to make our trip one of our best yet! His knowledge of the places we went to and the routes to get there was top notch. We loved him greatly and found a friend for life!
Gabor who helped plan our trip through KimKim is/was a Saint!! I know I drove him crazy with my itinerary changes, questions and concerns, and he just couldn't have handled me better! Haha He was so patient, so detailed and just definitely one of the reasons our trip went so well. He even called me towards the end just to see how everything was going and helped to make a last minute adjustment we didn't know we needed to make.
Overall, I give KimKim and the people they brought into my life a 10 because they are an awesome trip planning site, and I love everything about our trip! I tell all my friends about your site because this isn't my first trip planned through you all and won't be my last!

domain: travel


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Cosplayer Elfnextdoor > Costume of Tamaki Suoh from Ouran High School Host Club
About this Costume
- Construction Details:
Coat and tie by Ninjadancer. Who owns me. Really. We wanted a set of cosplays we could man our booth in, and Tamaki and Kyoya were pretty much perfect for the job. I have way too much fun as Tamaki.
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Unhal (Rabi crop) and red onions (early Kharif crop) are two varieties.
NASHIK: With stocks of onion continuing to remain low, their prices have skyrocketed in Nashik.
On Thursday, the minimum price of Unhal variety of onions in the Lasangaon APMC stood at `2,501, while the maximum rate stood at `7,000. The average price per quintal of onion stood at `6,451.
On the other hand, minimum prices of red onions stood at `1,801 per quintal, while the maximum rate touched `6,001 per quintal. The average price per quintal of red onion stood at `5,500.
Lasalgaon APMC chairwoman Suvarna Jagtap warned that the repercussions of the present state caused by excess rains could be observed even next year.
APMCs or Agricultural Produce Market Commit-tees have been established to ensure farmers are safeguarded from exploitation by large retailers.
Presently, two varieties of onion are being traded in APMCs across Nashik, including Lasalgaon. The first variety in the market is Unhal or Rabi crop which has been harvested from March to June and is stored. The second variety in the market is red onion (an early Kharif crop) which should have been in the market by Diwali but arrived late due to excess rainfall. Nashik is the only region which harvests three onion crops in an agricultural year.
The average arrival of red onions during this period is about 20 to 25 thousand quintals per day in Lasalgaon APMC. However, at present, only 500 quintals is trickling in per day on an average. Ms Jagtap claimed that only two or three per cent of Unhal variety onions could be in the market as 80 per cent of them would have been destroyed.
“About one lakh quintals of onion have been imported from Bhutan, Nepal, Afghanistan and Egypt. They are being distributed in the metros. This onion is unlikely to make any dent as its colour and taste are different. Mostly hoteliers are using it,” Ms Jagtap added.
Former Shetkari Sangh-atana leader and onion farmer Haji Sandubhai Shaikh said that red onion from Khandesh and Kasma belt usually arrives in the markets during Diwali. However, he added that the recent rainfall has destroyed the crop and very little harvest is being taken to APMCs.
“The cost of saplings and labour has increased. Yet, farmers have begun planting Rangda onion or late Kharif crop,” Mr Shaikh said.

domain: economics


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The scenic suburb of Clovelly is hidden away behind the Kalk Bay mountain slopes, and overlooks Fish Hoek and the Silvermine Valley. The suburb was originally established as a fertile vegetable garden, supplying ships anchoring in Simons Town and was then called Klein Tuin which means Little Garden. Clovelly is today a quaint and quiet suburb consisting of just a few hundred houses. It is actually so quiet that it has managed to remain a well-kept secret, not even many Capetonians known where it is! The lower boundary of Clovelly is marked by the Silvermine River, which is surrounded by a wetland nature reserve. This haven for waterbirds is packed with indigenous reeds and other gems unique to the Cape Floral Kingdom, and has a network of boardwalks perfect for visitors to go for a gentle stroll.
The soft white sands of Clovelly Beach have been the starting point for relaxing morning and evening strolls around the Fish Hoek bay for generations and a small offshore ridge gives junior surfers a perfect little practice wave. Clovelly Beach provides a peaceful alternative to the busy Fish Hoek side of the bay.
Considered as one of the finest golf courses in South Africa, Clovelly Country Club is famous for its rolling, computer-irrigated fairways and undulating holes complementing its rich coastal environment. The club is set in the pristine and tranquil Silvermine Valley close to Fish Hoek, and offers its members and visitors a memorable experience. The Silvermine River, natural sand dunes and trees line the fairways with water features and a wide variety of birdlife such as guinea fowl, pheasant and steppe buzzards. Adjoining the club house is a pro shop, restaurant and driving range.
The Clovelly Wetland Walk undulates through a wonderful example of restored wetlands in an urban setting, which is a haven for various forms of wildlife, most notably birds. Visitors can enjoy a nice walk amongst this natural ecosystem. The walk is easy enough for beginners and kids, and is well marked and fun. To make sure you see all the wildlife in the wetlands, dont forget to bring your binoculars.
Nearby Points Of Interest

domain: geography


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Billy Joel is set to be a father for the third time this November.
The singer revealed in an interview with the Belfast Telegraph that his wife Alexis Roderick is pregnant with the couple's second child due to arrive next month.
Joel says he's been enjoying his second go-around at fatherhood with the couple's two-year-old, Della Rose.
"This one is pretty good," he says of the tot. "She sleeps through the night. I hope the next one will."
Joel is also a parent to Alexa Ray Joel with his ex-wife Christie Brinkley.
The singer has cut back on touring in recent years, but he's maintained his residency at Madison Square Garden. Joel will perform his 45th show there this Friday.
Photo: Getty Images

domain: celebrity


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(CNN) As an ER nurse, Terry Foster took care of individuals on their worst days. She loves her work and as president of the Emergency Nurses Affiliation, a gaggle representing roughly 50,000 nurses, she has met numerous others who share an identical dedication to serving to others. However he’s anxious about the way forward for his career.
“I labored in emergency rooms for 45 years and you will not hear individuals say that once more. I do not suppose you will see that type of mandate once more,” she stated.
One thing has modified with the Covid-19 pandemic, Foster stated. This alteration is amongst many captured within the 2023 Registered Nurse Survey by AMN Healthcare, a nursing staffing firm.
The semiannual survey of 18,000 nurses, launched Monday, factors to what AMN Chief Medical Officer Dr. Cole Edmonson known as a “excellent storm” of issues for the career that might depart the US well being care business with out nurses to which he wants.
The survey, performed in January, exhibits a gaggle of pros who care rather a lot about their work, but in addition exhibits a big drop in job satisfaction and a big improve in stress ranges. Many are contemplating leaving the career.
“A disaster in nursing is upon us,” Edmonson says within the survey.
Nurses usually like their career, surveys have discovered through the years. For greater than a decade, their job satisfaction has ranged between 80% and 85%. Nevertheless, when requested within the new survey whether or not they had been extraordinarily happy or in any means happy with their alternative of nursing career, the quantity dropped by as a lot as 10 proportion factors in comparison with the newest AMN survey, performed in 2021.
If 71% of nurses say they’re happy with their jobs in 2023, that is nonetheless rather a lot, however the decline is worrying, stated Christin Stanford, vp of buyer options for AMN Healthcare.
“I do not suppose any of us had been ready to see how drastic the decline has been in job satisfaction, psychological well being and well-being, and What the overall feeling of the nursing career immediately was,” she stated.
One other worrying signal, she stated, is that youthful nurses appear much less happy with their careers than older professionals.
Analysis has proven that nurses who’re happy with their jobs sometimes keep on the job. However solely 63% of millennials and 62% of Gen Zers stated they had been happy with their profession alternative, in comparison with 78% of child boomers.
“The general knowledge may be very regarding. However in the event you phase and take a look at a number of totally different junctions or populations inside the survey knowledge, it is much more regarding,” Stanford stated.
The survey discovered that many nurses are contemplating leaving their jobs.
Hospitals might face the best instability. Solely 15% of hospital nurses say they are going to proceed in the identical job in a yr, in keeping with the survey.
Almost a 3rd of all nurses surveyed stated they had been more likely to depart the career, up 7 factors from the 2021 survey.
Solely 40% stated they might keep in the identical job in a single yr, a 5 proportion level drop from 2021. The remaining stated they might search for work as a journey nurse, swap to a part-time or day job, take a outdoors nursing or affected person care, or again to highschool.
Foster, who works as an emergency room nurse in northern Kentucky and was not concerned within the AMN survey, partly blames typical burnout. About 100,000 registered nurses in the USA have left their jobs because of the stress of the Covid-19 pandemic, in keeping with the outcomes of a survey launched this month by the Nationwide Council of State Boards of Nursing.
Foster says sufferers and their households have additionally modified in recent times.
“There’s only a new degree of public incivility,” he stated.
The identical violence seen in social media movies of individuals attacking flight attendants or quick meals staff is more and more taking place in healthcare settings, he stated. Healthcare staff are 5 instances extra more likely to expertise office violence than staff in all different industries, authorities surveys have discovered.
“We’re simply attempting to handle individuals they usually lash out at us,” Foster stated. “It is the sufferers who do not wish to wait, or they act out or they’re very dramatic or violent. And typically our sufferers are nice, however their households lash out at us and threaten us.”
This new survey confirmed that 4 in 5 nurses stated they skilled ‘rather a lot’ or ‘plenty of stress’ of their work, a rise of 16 factors from 2021.
A number of nurses stated they feared their job was taking a toll on their well being and infrequently felt emotionally drained.
Almost 40% of nurses surveyed stated they felt exhausted. Almost a 3rd stated they felt misunderstood or undervalued, and about the identical quantity felt they weren’t getting what they wanted from their jobs.
One other a part of the issue is the shortage of enough workers.
Solely a 3rd of respondents stated they’d the perfect time they wanted with sufferers, a 10-point lower from 2021. The share of nurses happy with the standard of care they had been capable of present decreased by 11 factors, from 75% in 2021 to 64% in 2023.
Stanford stated that in simply a few years, the career will lack 1 million nurses, partially as a result of a altering demographic.
Child boomers are reaching retirement age and there will probably be extra demand for nurses as a result of child boomers are additionally reaching the age the place they want extra medical care.
One other drawback is training. Whereas the variety of candidates who cross the nursing license examination has grown steadily through the years, in keeping with the Nationwide Nurses United union, there are nonetheless much more individuals eager to change into nurses than there are courses. Colleges merely haven’t got sufficient individuals to show, Stanford stated.
There might also be a scarcity of curiosity in doing the job in immediately’s atmosphere.
There are roughly a million registered nurses with energetic licenses who aren’t employed as nurse practitioners, in keeping with a Nationwide Nurses United evaluation of 2021 Bureau of Labor Statistics knowledge.
Popping out of the pandemic, too many hospitals have reduce workers and allowed for a better nurse-to-patient ratio, stated Kristine Kittelson, an RN in Austin and a member of Nationwide Nurses United. In essence, this has positioned nurses in an ethical dilemma, she stated, the place they can not totally assist their sufferers even when they wish to.
“We’re put in these powerful work environments which have actually pressured us to really feel that we, as nurses, aren’t offering the very best care potential,” Kittelson stated. that he was additionally not concerned within the new ballot. “We’re simply not being given the sources we’d like and the workers we’d like.”
Extra flexibility in schedules might assist, Stanford stated. Do nurses have sufficient flexibility to take day without work and handle themselves?
Almost all nurses who participated within the new survey stated they needed extra workers help, a discount within the variety of sufferers per nurse, a rise in wage, a safer work atmosphere and extra alternatives to share their contribution with the choice course of.
“It is a nice career and it’s totally rewarding, however I feel the pandemic has actually proven how undervalued we’re,” Kittelson stated. “We should always simply be capable to put ourselves ready to offer sufferers what they deserve and never really feel burdened.”

domain: sociology


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At the Attleboro Y, we understand that swim lessons are more than just stroke development. As they learn to swim, children also develop endurance, self-confidence, and an appreciation for water safety. The Y staff works hard to create an encouraging atmosphere in the water, where each swimmer can learn and progress at his or her own rate and comfort level.
SUMMER 2021 SWIM LESSONS
Jump in to a great summer of safe, water fun with swim lessons at the Y! This summer, we’re excited to offer a few different lesson formats and locations, so you can choose the class that best meets your family’s needs!
Weekly Swim Lessons
In our traditional swim lesson format, children swim once a week to progress through the swim stages from early water acclimation and water safety through stroke development. Offered indoors at the Downtown Branch during the week and outdoors at the Norton Outdoor Center on weekends!
Express Lessons at the Norton Outdoor Center
Our summer express lessons give preschool-aged and youth swimmers an opportunity to work on their swim skills with an instructor four days in a row. Through this more condensed and focused format, young swimmers get more practice to develop their skills and gain confidence in their swim abilities. Sign up for one week or as many weeks as you like!
Summer Swim Lesson Dates and Fees:
July session: July 5-August 1
August session: August 2-29
Weekly Express Sessions: Begin the week of July 5th
Member Registration: Begins June 1st
Non-Member Registration: Begins June 14th
Fee for Y Members: $60
Fee for Non-Members: $90
(Fee is per 4-class session. Monthly for traditional format. Weekly for Express.)
Please note: Parent/Child Swim Lessons are included in your Family or Single-Parent Family Membership. Call (508) 222-7422 for details.
For more information about our current Health & Safety Protocols, please go to attleboroymca.org/healthandsafety.
To register: Call the Y at (508) 222-7422 or register online vis the appropriate link below:
Parent/Child Lessons (6 months-3 years)
Preschool Lessons (3-5 years)
Youth Lessons (6-12 years)
All of our Swim Lesson sessions are organized according to the following swim levels:
Recommended Age Range: Infants & Toddlers (6 mos. – 3 yrs.) with Parent
In this parent-child category, children learn to be comfortable in the water. Swim Starters focuses on developing swim readiness skills through fun and confidence-building experiences. Parents also learn essential skills in Swim Starters, including how to best supervise children in the water, how to prevent accidents, and how to plan for emergencies.
Stages A & B – Water Discovery and Exploration
Introduces infants and toddlers to the aquatic environment. Focuses on exploring body positions, blowing bubbles and fundamental safety and aquatic skills.
Recommended Age Ranges: Preschool Youth (3–5 yrs.), School-Age Youth (5–12 yrs.), Teens & Adults (12+ yrs.)
In these three stages, students develop a high level of comfort in the water by practicing safe water habits, engaging in underwater exploration, and learning how to swim to safety and exit if they fall into a body of water. Group activities that reinforce learning help students progress. By the end of this series of stages, students achieve basic swimming competency by learning two benchmark skills – “swim, float, swim” and “jump, push, turn, grab.”
Stage 1 – Water Acclimation
Increases comfort with underwater exploration and basic self-rescue skills performed with assistance. While using flotation device, swimmers will learn to swim independently in correct body position, become comfortable getting face wet, floating on back and jumping into the pool without assistance.
Stage 2 – Water Movement
Encourages forward movement in water and basic self rescue skills performed independently. Swimmers in this level swim independently with flotation device, get their face wet, and jump in and exit pool without assistance. Swimming in correct body position, forward movement, back gliding and safety skills will be emphasized.
Stage 3 – Water Stamina
Develops intermediate self-rescue skills performed at longer distance than in previous stages. At this level, students swim without a bubble or with only a single slice flotation. They will learn to swim in a correct prone front position with face in the water and back glide 10 yards without bubble. This class builds endurance to swimming on front one length of the pool without flotation device and develops stroke technique on front and back.
Recommended Age Ranges: School-Age Youth (5–12 yrs.), Teens & Adults (12+ yrs.)
In these three stages, having mastered the fundamentals, students learn additional water safety skills and build stroke technique, developing skills that prevent chronic disease, increase social-emotional and cognitive well-being, and foster a lifetime of physical activity.
Stage 4 – Stroke Introduction
Introduces basic stroke technique in front crawl and back crawl and reinforces water safety through treading water and elementary backstroke. Rhythmic breathing & flutter kick will be practiced.
Stage 5 – Stroke Development
Introduces breaststroke and butterfly. Reinforces water safety through treading water and sidestroke. The four competitive strokes and sidestroke will be taught. Participants should be able to swim length of pool with proper rotary breathing before joining this class.
Stage 6 – Stroke Mechanics – Pre-Competitive Swim Groups
This introduction to competitive swimming refines stroke technique on all four competitive strokes, builds endurance, and encourages swimming as part of a healthy lifestyle.
Seahorses: For youth with special needs
These 30-minute classes have smaller student-to-instructor ratios to help acclimate children with special needs to the water and teach them basic swimming skills. Parents and/or aides are welcome to get in the water to help during the class.
For more information, call (508) 222-7422.
Ages 3- adult
The Y staff will be happy to work with you and your family in small groups or individually. Call (508) 222-7422 to schedule your lesson.
Y Member: $25 per 30-minute lesson
Non-member: $40 per 30-minute lesson
6 pack of 30-minute lessons
Y Member: $135


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Acclaimed Graffiti Artist takes on the Olympics
Graffiti art mural sets to unite disparate communities
Internationally acclaimed graffiti artist Mohammed Ali has painted an art mural in London on Leyton High Road from 10am-5pm. The mural has brought local young people from the Leyton area together to create a thought-provoking piece of public art, minutes away from London’s Olympic stadium.
Leyton High Road has already been in the media spotlight for sprucing up its shop-fronts in time for the London 2012 Olympics. The East End has also been accused of wiping out its vibrant street art because of it being considered low brow. Mohammed Ali’s art with its uplifting message seeks to challenge that perception, as he says “street art brings life to the concrete jungles that we live in”.
The British-born artist has produced murals in New York, Chicago, Melbourne and Dubai. The South Bank Award winner has been featured on Al-Jazeera, BBC, New York Times and many others prestigious publications. He says of the upcoming project:
“The world might have come together for the Olympics but this time last year London was a place of riots and factions, this project is a perfect opportunity to transcend class, race, and faith to bring all peoples together through art. I didn’t want to paint just a nice pretty mural about the Olympics, but wanted to ask important questions and make people think.”
“He is a graffiti artist who uses his work to intertwine the old and the new…his work has been dubbed ‘urban spiritual art’ was originally street based but now hangs in galleries all over the world…he is heralded as a bridge of understanding” Freema Agyeman, South Bank Show Awards 2009.
The large scale project funded by Near Neighbours, involves young people from youth organisation Adventure Quest, Leyton Scouts and arts organisation Soul City Arts. The mural is located on the corner of Huxley Road and Leyton High Road, on the side of the Kebabish Original Restaurant.
A feature in the Waltham Forest Guardian newspaper: http://www.guardian-series.co.uk/news/wfnews/9872020.LEYTON___Thought_provoking__Olympic_mural_completed/?ref=mmsp
For more info contact: Tam Hussein / 07982996790
A picture of the wall to be painted:
Pictures of the completed mural showing the process from beginning to end:


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Human Rights Watch and Amnesty International have joined 40 other rights groups to express their “deep concern” over the UAE’s “sustained assault on human rights and freedoms” as the Gulf state prepares to host the 28th United Nations global climate talks (COP28) later this year.
“For more than 10 years, UAE authorities have been unjustly detaining at least 60 Emirati human rights defenders, civil society activists, and political dissidents who were arrested in 2012 because of their demands for reform and democracy,” a joint statement released yesterday said.
“More than three-quarters of these prisoners have completed their sentences yet remain in arbitrary detention to date. UAE authorities refuse to release them, alleging that they continue to pose a “terrorist threat,” based on vague laws that allow their indefinite detention, in flagrant violation of international human rights law.”
The detainees, they added, include activists, academics, lawyers, university professors and royal family members. While their detention and the use of the criminal justice system as a tool to eliminate the human rights movement have “led to the closure of civic space, severe restrictions on freedom of expression, both online and offline, and the criminalization of peaceful dissent.”
Even the families of detainees have not been spared, the statement highlighted, “In some cases, the UAE authorities have arbitrarily revoked the citizenship of detainees and their families, depriving them of their rights as Emirati nationals and leaving them stateless. In other cases, the authorities have imposed travel bans on their family members, prevented them from studying or working, and frozen their bank accounts.”
As the UAE will host the 28th United Nations global climate talks (COP 28) from 30 November to 12 December 2023, we express our deep concern over the human rights situation in the country, particularly the severe restrictions imposed by the authorities on the rights to freedom of expression and peaceful assembly, which seriously undermine the work of civil society and the space for political dissent in the country.
Read more middleeastmonitor.com
Photos: middleeastmonitor.com,Waleed Zein – Anadolu Agency


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Funded support to help farmers manage and establish woodland
FAS works with farmers and crofters to determine if woodland creation is a viable revenue source by providing funding for expert consultancy in the form of one-to-one specialist advice or an Integrated Land Management Plan (ILMP).
The Forestry Grant Scheme helps farmers and crofters to derive revenue from less productive agricultural land by providing a range of financial support packages to help them to create new woodland or to manage existing woodland sustainably.
During the ILMP process, farm-specific opportunities and financial incentives available to create or manage woodland will be reviewed. Those that undertake an ILMP are also entitled to funding for specialist advice from FAS. This can be used to appoint a forester or woodland specialist to develop professional woodland creation plans that chart paths to business success.
Caroline Wood, one-to-one programme manager for the Farm Advisory Service said:
"Farmers play an important role in maintaining and protecting Scotland’s woodlands, which are a vital national resource and essential for rural development and sustainable land use. The support available from the Farm Advisory Service can help farmers and crofters make woodland creation part of a long-term strategy for their businesses."
The Scottish Government will fund up to 80% of the cost of developing an ILMP – up to a maximum of £1,200.
To find out more about the FGS, please visit the Forestry Commission Scotland website.
For more information on how to get support from FAS and chart a path to sustainable business development, please visit the advice and grants section of the FAS website for more information.


Table of Contents
Discover our opinion on the new generation of X41 by CODE41 and its amazing sapphire case ! To push the transparency of a skeleton watch to its climax!
The X41, a success since its launch
Even before its launch, the MBA blog introduced you to the X41 watch, the “luxury watchmaking” model from Code41. We were talking about it as a future phenomenon and history has proven us right. Each edition met a huge success with 1850 pieces sold and more than 9 million euros in turnover! Those who wrote that a young Swiss brand could not break into the elitist segment of watches over €5,000 did not understand the driving power of the Lausanne brand and its thousands of fans, who participate by their votes. at each stage of watch design (choice of design, materials, finishes, etc.).
The quality of the Swiss movement, the ultra-modern design of the X41 skeleton watch and word of mouth have made the X41 an unprecedented success in this price segment hitherto reserved for well-established Swiss brands with industrial production such as Omega or Rolex. CODE41 has breathed new life and originality into this market and we can only be delighted!
A new X41 edition with a sapphire case!
For this new edition of the X41, CODE41 continues its quest for luxury and ultra-transparency with an all-sapphire case. A performance rarely offered, we nevertheless think of exceptional pieces such as the MP05 Laferrari Sapphire of Hublot or the RM 56-01 Sapphire Crystal Tourbillon from Richard Mille, watches with hallucinating prices. The idea of a watch with a sapphire case appeared in the 1980s with the brilliant watch designer Vincent Calabrese, but few brands have offered models because it is a complicated technology to master and obviously very expensive in terms of production costs.
Designing a sapphire case is a technical challenge first class. The latter is initially much more expensive to produce than a titanium case: €3300 against €150, or 22 times more expensive! It is also more complex and longer to work with (machining, polishing, drilling, assembly: all production stages must be specifically reviewed for this demanding material) than the two materials proposed so far for the X41, AeroCarbon and grade 5 titanium.
Allowing no errors in design or cutting, the sapphire case is only offered by a few Haute Horlogerie brands and at incredible prices…
The advantages of a sapphire case
If the sapphire case brings a code of ultra-luxury and a great originality compared to the watches currently offered on the market, the technical characteristics of the sapphire also give it many advantages:
– the exceptional hardness of sapphire gives it a scratch resistance far superior to that of steel, titanium and carbon. Only diamond surpasses sapphire in hardness.
– the lightness of sapphire ensures optimal comfort on the wrist, being twice as light as steel.
– and especially the transparency of sapphire made of the X41 a captivating skeleton watchwe can contemplate its movement from all angles.
The other new features of this edition of the X41
In addition to the sapphire case, the brand founded by Claudio d’Amore has made other changes compared to the previous X41s:
– new colors for bridges: after offering 9 different colors to the CODE41 community, it’s the green And the Rainbow (which we like very much) who have been chosen. For this, CODE41 collaborates with Positive Coating, a Swiss specialist in the coating of watch components based in La Chaux-de-Fonds.
– A translucent bracelet to accompany the sapphire model: to offer the most immersive transparency experience.
Technical characteristics of the X41 watch
– three materials available for the case: sapphire as we have seen for total transparency but also a grade 5 titanium And AeroCarbon as on previous generations of X41.
– A truly swiss movement : designed, manufactured and assembled entirely in Switzerland, in small series.
– the famous exclusive peripheral oscillating mass which ensured the success of the X41 from its launch through the technical performance and the extreme transparency it offers on the movement.


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Tehran, Iran, Jan. 7
By Mehdi Sepahvand - Trend:
Afghanistan is willing to import one million metric tons per annum of gas oil from Iran, Iranian Oil Minister Bijan Zanganeh said.
Speaking after a meeting with Afghan Minister of Trade and Industry Homayoun Rasa in Tehran, Zanganeh said the two countries will continue talks about the prices of oil products, SHANA news agency reported January 6.
Afghanistan used to receive $100 for each metric ton of gas oil imported from Iran with no privilege over other countries, but the issue is going to be amended, he said.
Iran is currently exporting 200 thousand metric tons of gas oil to Afghanistan, which is also seeking 200 thousand metric tons of LPG for which the price has to be settled, according to the Iranian official.


text: HAS ANY country ever lost as many jobs as India shed in April? After the government imposed a strict lockdown on March 24th, employment fell by 114m in the following month, according to the Centre for Monitoring Indian Economy, a research firm. The number, it said, was “mind-boggling”. It has also been mind-concentrating. Although employment…View More Will labour reforms in India work?


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Boozman: Thank you to all who march for life
Jan 21 2022
WASHINGTON - Today, thousands of Americans are raising their voices and demonstrating their support for the unborn in the annual March for Life on the National Mall. Like me, they believe in the dignity of every person and are standing in defense of the those who cannot defend themselves.
I was proud to join these voices in protecting the unborn and fighting to end abortion during the recent Arkansas March for Life just as I joined pro-life advocates on the steps of the U.S. Supreme Court last month when the court heard arguments in a case that could undo Roe v. Wade for good and send the question of abortion back where it belongs: to the states.
As the 49th annual March for Life unfolds in the nation’s capital, we pray this will be the last march petitioning for the protection of life. Because of the hard work of so many for nearly five decades, that day is now within reach.
Defending the most vulnerable among us is one of the most important things we can do. I’m proud to support legislation that protects the rights of the unborn and the conscience rights of taxpayers who don’t want their tax dollars paying for abortions. That’s one reason I’ve again earned an A+ on the Susan B. Anthony List Pro-Life Scorecard. I will continue to defend and support the right to life.
Boozman Joins Kudlow to Highlight the True Cost of Biden’s Reckless Tax-and-Spending Spree
Dec 13 2021
Boozman joined Kudlow on Fox Business Monday to discuss the historic inflation rates and the nonpartisan Congressional Budget Office’s updated analysis on the actual cost of President Biden’s reckless tax-and-spending bill.
Boozman Talks Veterans Day, VA Legislation, LRAFB and Infrastructure on THV11's Wake Up Central
Nov 12 2021
Boozman Joins Fox16 News, Discusses SERVICE Act to Enhance VA Breast Cancer Screenings and Care
Oct 29 2021
Boozman: President’s Tax and Spend Proposal a ‘Gut Punch’ to Rural America
Calls for Ag Committee Hearings on Administration’s Radical Plan
Oct 28 2021
WASHINGTON––U.S. Senator John Boozman (R-AR) is warning Americans about the negative consequences of President Biden’s reckless tax and spending agenda.
“The president’s plan would be an absolute gut punch to our family farmers and rural America as a whole, especially as inflation continues to skyrocket under this administration’s watch,” Boozman said in a speech on the senate floor.
Boozman has repeatedly pushed back on the president’s $3.5 trillion partisan plan. In August, the senator rejected the Biden-backed budget resolution and has since been highlighting its outrageous cost and left-wing, fundamentally flawed framework.
As ranking member of the Senate Committee on Agriculture, Nutrition, and Forestry, Boozman has called for public hearings, with witnesses, so agriculture producers and stakeholders in rural America have an opportunity to offer input on the proposal.
“There is a feeling among many of the people who do not live in our nation’s cities that their political leaders do not value their expertise, or their opinions, and do not understand their lives,” Boozman said during an ag hearing on Wednesday. “When the Senate agriculture committee decides to forgo the expertise and opinion of those we are entrusted to represent, we are not living up to what should be our commitment to our farmers, ranchers, and rural communities.”
This is the second time this year Democratic leaders have bypassed the committee process as the Biden administration aims to advance radical policies despite an evenly divided Senate and Democrats’ slim majority in the House of Representatives.


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Give your vintage-style sleep sanctuary a modern twist with statement lighting – channel the look with these Lotus Flower pendant shades. Warm throws and cushions in soft pastels make your bedroom feel cosy and inviting. Create an easy update by propping paintings and framed prints against the wall for a chic Parisian apartment look.
Haley & Raven - We used to come here, the record player in your room was always on. I miss us, I miss you... Why did I push you away? I'm so stupid! I... I'm sorry. I wish I could say that to you. ~ Haley
Kitsch retro 50's style kitchen inspiration , with vintage crockery and baby pink but not overstated in pattern so it still retains the feel of the clean contemporary home


The GeoMarketing Top 5 Countdown
It's 2016! Here's how all the mobile news is shaping up in the New Year.
By Lauryn Chamberlain, Jan 8th
WPP’s Light Reaction Is Prepped For The End Of Media Silos
After being grown as an extension of Xaxis, Light Reaction is expanding the notion of what performance means.
By David Kaplan, Dec 30th
Light Reaction Taps Rosa Markarian And Promotes Jennifer Lucas To Management Team
Both women have worked within Light Reaction or its parent company Xaxis for several years prior to their promotion.
By Daniel Parisi, Nov 3rd
How Brands Can Partner With Google Assistant
By David Kaplan, Oct 2nd
Announcing Our New Venture: CMO On The Go!
By Lauryn Chamberlain, Sep 27th
IBM Watson Unveils Added AI Tools For Marketers, Including Weather-Related Ad Designs
By David Kaplan, Sep 26th


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By SJA Jafri
MELBOURNE/ ISLAMABAD: Chief of Army Staff, General Qamar Javed Bajwa has endorsed punishment to two Army and one civil officer on the charges of espionage/leakage of sensitive information to foreign agencies prejudice to the national security.
Inter Services Public Relations (ISPR), the media wing of the military, in a statement said “The officers were tried under Pakistan Army Act (PAA) and Official Secret Act by separate Field General Court Marshal (FGCM) for separate cases.”
Lieutenant General Javed Iqbal (retired) was awarded 14 years rigorous imprisonment, while Brigadier Raja Rizwan (retired) awarded death sentence, the statement said.
While, doctor Wasim Akram (Employed at Sensitive Organization) was awarded death sentence.
Sources claimed that Pakistan has arrested retired Pak army Lt Gen Javed Iqbal Awan for spying for CIA and another severe crime against an oppressed community in Pakistan for more than 14 years. He was commander of Bahawalpur based 31 corps and was also DGMO and Adjutant General of Pak army. He retired in 2016 and was working for CIA 2004 onwards.
Meanwhile, a retired brigadier accused of having links with banned outfit Hizbut Tahrir (HT) and planning attacks on the Military General Headquarters (GHQ) has also dismissed from service against spying and other harsh offenses.


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Oct 19 (Reuters) - MANITOU BF SA ::Q3’17 REVENUES OF €354M, +10% VERSUS. Q3’16, +7% LIKE FOR LIKE.CUMULATIVE 9-MONTH SALES OF €1,159M, +15% VERSUS. Q3’16, +13% LIKE FOR LIKE.Q3 ORDER INTAKES ON EQUIPMENT OF €312M VERSUS. €206M IN Q3’16. END OF Q3 ORDER BOOK AT €526M VERSUS. €244M IN Q3’16 AND €344M IN Q4’16.SAYS CURRENT DEPTH OF ORDER BOOK AND POSITIVE BUSINESS OUTLOOK CONFIRMS PROSPECTS FOR 2017.
Oct 19 (Reuters) - Climate Corporation::THE CLIMATE CORPORATION ANNOUNCES GLOBAL DATA CONNECTIVITY AGREEMENT WITH AGCO, OFFERING MORE FARMERS THE ABILITY TO CONNECT THEIR FARM EQUIPMENT TO THE CLIMATE FIELDVIEW™ PLATFORM.CLIMATE CORPORATION SAYS ANNOUNCED A DATA CONNECTIVITY AGREEMENT WITH AGCO.
Oct 19 (Reuters) - WABCO Holdings Inc :WABCO reports Q3 2017 results; continues to strongly outperform global commercial vehicle market; raises guidance for 2017.Q3 earnings per share $1.30.Q3 sales $827.8 million versus I/B/E/S view $752.4 million.Q3 earnings per share view $1.53 -- Thomson Reuters I/B/E/S.WABCO Holdings Inc - raises reported diluted EPS guidance for full-year 2017 to now range from $5.95 to $6.10.WABCO Holdings Inc - Q3 2017 diluted EPS $1.30.WABCO Holdings Inc - raises sales guidance for full-year 2017 to now range from $3,250 million to $3,300 million.FY2017 earnings per share view $6.34, revenue view $3.11 billion -- Thomson Reuters I/B/E/S.
Oct 19 (Reuters) - Kion CFO tells Reuters:Expects customers' project delays to be a short-term trend, not a fundamental shift.Monterrey factory now on track after start-up problems.Raw material prices rise has accelerated in Q3.Says strong growth in forklift truck business driven by Europe, China, South america, Turkey, Russia.
Oct 19 (Reuters) - Kion Group Ag :dgap-news: kion group publishes preliminary results for the first nine months of 2017 and slightly adjusts outlook.9M order intake was eur5.699 billion.9M revenue of eur5.675 billion.9M adjusted ebit was eur561.8 million, resulting in an adjusted EBIT margin of 9.9 percent.
Oct 18 (Reuters) - NanJi E-Commerce Co Ltd <002127.SZ> ::Says its unit plans to set up an e-commerce JV in Xinjiang, jointly with co's actual controller Zhang Yuxiang .JV will be capitalized at 10 million yuan and the unit will own a 90 percent stake .
Oct 17 (Reuters) - Deere & Co ::Says court ruled in favor of Co in lawsuit filed to protect use of trademark green, yellow color combination on John Deere agricultural equipment.Says court decision permanently bans use of John Deere colors by Fimco, Inc.
Oct 17 (Reuters) - TALGO SA ::Says plans to build a plant in the United Kingdom and create a fully localized supply chain.Says already visited potential places around Leeds and Liverpool.
Oct 17 (Reuters) - Volvo Ab :Volvo group discontinues the process to divest governmental sales.Volvo ab says offers we have received for governmental sales do not reflect its value.


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Choose your room
With a stay at Sherwood Prize Hotel in Antalya (Lara), you'll be minutes from Shemall Shopping Center and Laura Shopping Center. This hotel is within close proximity of BLM Beach and Terra City Shopping Center. Enjoy the recreation opportunities such as a seasonal outdoor pool or make use of other amenities including complimentary wireless Internet access. Featured amenities include dry cleaning/laundry services, a 24-hour front desk, and a safe deposit box at the front desk. Make yourself at home in one of the 28 air-conditioned rooms featuring minibars. Rooms have private furnished balconies. Complimentary wireless Internet access keeps you connected, and satellite programming is available for your entertainment. Private bathrooms with showers feature complimentary toiletries and hair dryers.
Useful information:Other names for Hotel Prize:


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Latest Detroit Medical Center Stories
DETROIT, Oct. 26 /PRNewswire-USNewswire/ -- The DMC Board voted this afternoon to extend their definitive purchase agreement with Vanguard Health Systems through the end of the year, allowing more time to complete governmental approvals.
TROY, Mich., Oct. 5 /PRNewswire/ -- CareTech Solutions, an information technology and Web products and services provider for more than 150 U.S.
DALLAS, Oct. 1 /PRNewswire/ -- DMC Sinai-Grace Hospital has selected Dallas-based Loopback Communications' technology-leading Readmission Reduction(TM) solution to support its efforts to reduce readmissions of discharged patients.
DETROIT, Sept. 20 /PRNewswire/ -- Detroit Medical Center (DMC), announced today that it was named to this year's InformationWeek 500, an annual listing of the nation's most innovative users of business technology.
DETROIT, Aug. 30 /PRNewswire-USNewswire/ -- The Detroit Medical Center (DMC) achieved significant improvements in patient safety and quality of care, while also saving more than $5 million in costs last year, thanks to efficiencies created by its system-wide Electronic Medical Record (EMR).
TROY, Mich., July 21 /PRNewswire/ -- CareTech Solutions (www.caretech.com), an information technology (IT) and Web product and services provider for hospitals, announced today that ten of its clients have been recognized as one of the nation's 2010 Most Wired, according to the results of the 2010 Most Wired Survey in the July issue of Hospitals & Health Networks (H&HN) magazine. CareTech Solutions provides IT services and/or Web products and services to the following winning client...
DMC Outlines $500 Million Expansion at "Construction Outreach" Event DETROIT, July 19 /PRNewswire-USNewswire/ -- Detroit Medical Center (DMC) launched its long-awaited new construction and expansion program Friday, July 16, 2010, during a "Construction Outreach" event that announced the creation of an estimated 5,000 local jobs for the building industry. "This is a major step forward for Detroit and Southeast Michigan," said DMC President and CEO Michael Duggan.
New Most Wired Survey Methodology Launched CHICAGO, July 7 /PRNewswire-USNewswire/ -- Hospitals understand the importance of health information technology (IT) and the benefits of its widespread adoption, yet as a field still face significant barriers to implementation according to a newly released survey of America's Most Wired hospitals and health systems. This year's survey reveals continued progress for hospitals in patient safety initiatives: Fifty-one percent of medication orders were...
- The parings of haberdine; also, any kind of fragments.


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Hello fellow pilots and pilotess.
I would like your help in trying to change things around here.
The hate and rants runs wild on this forum, and this is not good for neither us or the development team of our beloved game.
The gap between us and the devs is growing bigger and bigger, and this doesn’t help the comunity, nor the game.
Let’s try and change this things.
The recent introduction of the Relics, has launched a new campaign of bash the devs and the game, and has fired up alot of negative reactions and rants, that frankly have nothing to do with what this comunity should be about.
I would like to propose an alternative use of these relics,one that will benefit the game, and the players.
This is an ideea of it:
Use relics to close the gap of epic hp modules and protector :
- 1 maxed epic plate + 1 another random legendary + 1 or 2 relics = 1 legendary hp plate.
- 1 maxed epic protector + 1 another random legendary +1 or 2 relics = 1 legendary protector.
- 1 maxed epic shotgun + 1 random legendary + 1 or 2 relics = legendary shotgun
- 1 maxed epic flamer + 1 randon legendary + 1 or 2 relics = legendary flamer.
- 1 maxed epic rocket + 1 random legendary + 1 or 2 relics = legendary rocket
- And it can further gain some other uses :
- A random legendary + 1 relic = 1 new random legendary.
- A random myth + 2 relics = 5 new random legendaries
- A random epic + 1 relic = 2 random epics(with a chance of legendary).
This can add a new dimension to the game, and can actualy make the relics usefull.
They can still be used also as in the initial ideea, transformation materials.
The numbers are for example, they can get bigger or lower.
I am asking for your feedback on this ideea, specialy Mohadib, since he is the brain and main dev that has the magic wand to change things.
Reassons to make this change of use:
If the Relics are maintained as initialy intended, they become pretty useless, since there are cheaper ways of obtaining transformation materials.
They will dilute the chances of obtaining good legendaries thruout purchases and drops.
This will further strech the gap that is now between the comunity and the devs.
There is a high posibility that a number of players will let go of the game.
This new dimension that is beeing proposed, fullfils the needs of both lower tier, and higher tier players.
It can solve the gap between epic plates/protector and legendary ones. Thus resolving the lack of competitive play in the ladder.
It will allow the players to disolve unwanted myths and help them build new mechs.
This new Relic will find value, and you would create a new resorce that creates a new dimension of this game.
The possibility of actualy getting, thru very hard work and at a decent price, items, could reboot the game in the right direction. In the past the fact that you could obtain myths at a ressonable price, was what made players spend. Now if a players spends 100$ and gets unwanted items,will discourage him from further purchases.
I think that introducing this relic as the above mentioned format, will increase the low and mid tier spender. The big purchases will still be around, knowing that their money is actualy getting them something, but at the same time the low and mid purchaser will be also pleased that his money could get him something. Thing about a mid constant cash flow, that comes evry month, instead of big gallops of it.
It would show that the comunity is part of the game, and not some folks that are standing behind the wall, with pitchforks and torches, ranting at evrything that comes out. Because at some point, they will get bored of doing so and leave.
It doesnt mean that the items will be obtained fast, or easy, like i said the numbers are just for example, and they can be adjusted so that they end up as beeing resonably.
This can become an ideea of the comunity, and i think that if we want it to be heard, we need to stand united, and not in hateing and ranting, but in the sense of dialoque and comunication.
Let asside all the ill passions, and hate, let’s stop burning energy over negativity, let’s be constructive and positive.
@Mohadib, i really want your opinion on this. Because comunication is the key here.
Also remember that this is a game, it is ment to be fun.And it is up to us, as a team, devs and comunity to make it that way.
I will make a pool about it to see us, the comunity likes it.
- Yes, I like this ideea, of better use of the Relics. Let’s get it heard.
- No, I think that it should remain as initialy launched.

domain: game