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The 2016 New Hampshire primary, the first primary in the nation, is taking place today. The latest polls show that Donald J Trump is still leading the pack of Republican Party candidates. Likewise, Bernie Sanders is out front of his only rival, Hillary Rodham Clinton. Hillary does not really need a win today, though a large defeat may hurt her down the road. There is already talk about a major shake up in her campaign staff as the nomination fight heads to Nevada and South Carolina. For the GOP hopefuls, Trump is still leading nationally and in every other state poll. So the two big questions for Republicans are, will Trump win by a large margin and how will the other candidates finish? Three small towns already voted after midnight. In Dixville Notch, Bernie Sanders won all four Democrat votes while the 5 Republican votes were split 3 for John Kasich and 2 for Donald Trump. Trump, Kasich and Marco Rubio are all tied currently with 9 votes each from those early ballots.


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A recent example, Gary Dourdan -- the actor who formerly starred as a detective on "CSI" -- filed for bankruptcy in August. Dourdan claimed almost $15,000 a month in earnings but only $321 in disposable income after paying bills and other obligations.
What is it about being a celebrity that seems to lend itself to financial woes? Here are a few of the biggest reasons that celebrities can't seem to...
Why So Many Stars Have Money Trouble (and What You Can Learn From Them) originally appeared on DailyFinance.com on 2012-12-19T16:00:00Z.
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A 4-month first-line treatment regimen for tuberculosis disease (TB) is expected to have a direct impact on patient outcomes and societal costs, as well as an indirect impact on Mycobacterium tuberculosis transmission. We aimed to estimate this combined impact in a high TB-burden country: South Africa.
An individual based M. tb transmission model was fitted to the TB burden of South Africa using a standard TB natural history framework. We measured the impact on TB burden from 2015–2035 of introduction of a non-inferior 4-month regimen replacing the standard 6-month regimen as first-line therapy. Impact was measured with respect to three separate baselines (Guidelines, Policy and Current), reflecting differences in adherence to TB and HIV treatment guidelines. Further scenario analyses considered the variation in treatment-related parameters and resistance levels. Impact was measured in terms of differences in TB burden and Disability Adjusted Life Years (DALYs) averted. We also examined the highest cost at which the new regimen would be cost-effective for several willingness-to-pay thresholds.
It was estimated that a 4-month regimen would avert less than 1% of the predicted 6 million person years with TB disease in South Africa between 2015 and 2035. A similarly small impact was seen on deaths and DALYs averted. Despite this small impact, with the health systems and patient cost savings from regimen shortening, the 4-month regimen could be cost-effective at $436 [NA, 5983] (mean [range]) per month at a willingness-to-pay threshold of one GDP per capita ($6,618).
Citation: Knight GM, Gomez GB, Dodd PJ, Dowdy D, Zwerling A, Wells WA, et al. (2015) The Impact and Cost-Effectiveness of a Four-Month Regimen for First-Line Treatment of Active Tuberculosis in South Africa. PLoS ONE 10(12): e0145796. doi:10.1371/journal.pone.0145796
Editor: Joan A. Caylà, Public Health Agency of Barcelona, SPAIN
Received: June 1, 2015; Accepted: December 8, 2015; Published: December 30, 2015
Copyright: © 2015 Knight et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Data Availability: All relevant data are within the paper and its Supporting Information files.
Funding: This work was funded by the Global Alliance for TB Drug Development, New York, USA (http://www.tballiance.org/). RGW is funded by the Medical Research Council (UK) (MR/J005088/1), and the Bill and Melinda Gates Foundation (TB Modelling and Analysis Consortium: OPP1084276). One of the co-authors, William Wells, was employed by the funders at the start of this work. He contributed to discussions as to the initial directions for the project, the available data and current understanding of TB regimen design. The funders had no other role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests: The authors have declared that no competing interests exist.
South Africa suffers from an extremely high burden of TB, with increasing levels of drug resistance and an ongoing HIV epidemic . It has one of the highest gross domestic products (GDPs) in the WHO-identified 22 high TB burden countries . Recently, the South African Department of Health has invested heavily in TB control with the adoption and rapid rollout of the new diagnostic tool GeneXpert . However, there is still a high level of TB transmission occurring  at a large cost to health systems and patients [5–7].
Tackling this burden could be achieved, in part, by using a shortened first-line regimen. The current standard first-line treatment regimen for TB consists of daily administration of four drugs (isoniazid, rifampicin, ethambutol and pyrazinamide, HZRE) for 2 months followed by two drugs (isoniazid and rifampicin) for a further 4 months. Shortening the first-line regimen could reduce the burden on both patient populations and health systems. Several new shortened regimens are in the pipeline utilizing either new combinations of existing drugs or incorporating new compounds that offer promise going forward .
Policy makers use a wide range of evidence in order to make decisions. For the adoption of shortened regimens for TB, two such pieces of evidence are likely to be population health impact and cost-effectiveness analysis . These can be assessed using mathematical models that include the impact on patients and disease transmission. Previous mathematical models have investigated the impact of a shortened regimen on the number of TB cases and shown that it is likely to be relatively small (<10%) [10–13]. However, none have estimated the population-level impact and cost-effectiveness in a specific high-burden setting.
In this work we focused on assessing the impact of a hypothetical shortened regimen in a high TB burden country that has a strong track record of investing in TB control, South Africa. By fitting a dynamic transmission model explicitly to the TB epidemic in this country we then assessed the impact of a new shortened regimen of the most likely length (4-months) . We assumed that the regimen was equivalent, being non-inferior and not superior, and thus aimed to explore only the impact of shortening the treatment length. Specifically, we assumed that the number of deaths and proportion of cases cured at treatment completion was the same for both treatments and we did not include any margin of non-inferiority. We expanded previous cost-effectiveness analysis of shortened TB regimens  to include new recently collected cost data [6,7] and build upon work presented in a companion paper  to conduct a threshold analysis around the cost at which such a regimen could be cost-effective for South Africa, including transmission impact.
Materials and Methods
We modified a previously published, individual-based simulation model [15,16] to include a shortened TB treatment regimen length and fitted this to the current data on TB and HIV epidemiology in South Africa (see S1 Appendix for full details). We used this to evaluate the difference in TB burden over 2015 and 2035 between a scenario with continued use of the current standard 6-month TB treatment (isoniazid, rifampicin, pyrazinamide, ethambutol: 2HRZE/4RH) vs. a non-inferior shortened 4-month regimen for first-line treatment. We assumed that the new regimen contained rifampicin and thus was ineffective against MDR-TB.
Natural history of TB
The model has a standard natural history of TB framework (Fig 1) and includes age, HIV status and CD4 count, and TB infection history. Timing of development of TB disease after (re-)infection is influenced by HIV status and CD4 count; HIV status and age influence the probability of TB disease being smear-positive. TB infection from TB cases occurs in the community, the latter with age-dependent mixing. The model is built using C. For more information and all natural history parameters see S1 Appendix.
Resistance in TB assumptions
The impact of resistance on the probability of transmission is highly uncertain . Therefore, transmission of individual resistance profiles was not monitored in the model, nor was acquired resistance included. Instead we composed our TB cases of a weighted average of proportion of cases with drug sensitive and resistant TB. Two resistance categories were included: pan-susceptible and multi-drug resistant (resistance to isoniazid and rifampicin, MDR-TB) at 2015 levels in the main analysis for treatment-naive patients of 98.2% and 1.8% respectively . These levels were assumed to remain constant from 2015 onwards. We explored this assumption in our scenario analysis (see below). An individual who has received TB treatment before had a higher probability of MDR-TB in subsequent episodes of active disease, determined by a fixed odds ratio (3.72) .
TB Treatment assumptions
First-line therapy is prescribed to all who are detected with active TB. If rifampicin resistance is detected, via an assumed coverage of GeneXpert testing  (Table 1), then, dependent on MDR treatment coverage, there is some chance that this patient will be started on 24 month MDR treatment with set outcomes (Tables B&C in S1 Appendix).
Up to 2010, the Basecase levels were assumed.
Individuals become non-infectious upon appropriate treatment initiation [20,21]. At each month of treatment, a proportion of individuals on treatment were lost to follow-up (with or without cure) and a further proportion die (Fig 2). These outcomes depend on HIV and ART status, resistance and whether an individual has received TB treatment before (Table 2).
The cumulative percentage of the initial population starting treatment is shown with each of the different possible outcomes.
* /H = parameter does not differ by HIV status. ** /R = parameter does not differ by resistance status. MDR = multi-drug resistance, resistance to standard regimen. aSplit in the ratio (3,2,1,1) over the first 4 months bBoth standard and new regimens are ineffective against MDR. Background rate of self-cure included.
There are 18 separate treatment outcome combinations that depend on treatment regimen (standard, shortened or MDR), type (first or re-treatment) and HIV status (HIV+ no ART, HIV+ on ART, HIV-). For example, for new patients without HIV the treatment outcomes are given in Fig 2. These are composed of weighted averages over the resistance profiles (which differ if on re-treatment). Resistance (both MDR and to the new regimen) increases the probability of mortality  and decreases the probability of cure during and at treatment completion [23–25]. Those with HIV have a higher mortality, which is partially mitigated by ART , and is increased by TB resistance . Outcomes during retreatment are worse, with higher mortality rates, which are also dependent on HIV and resistance status [22,26,28,29]. For further details on all parameters see Table B and the S1 Appendix.
The model was calibrated using a Nelder-Mead simplex algorithm to minimize a sum of squares error term measuring the distance between TB incidence, HIV and ART data and the estimates by WHO , UNAIDS , and South African component of ZAMSTAR  (for more information see S1 Appendix). The model fitting used the base case parameters (see Table 1) except for the scenario of high default. The model was fitted separately to the data assuming this level of default.
The new 4-month regimen was assumed to be non-inferior to the standard regimen, based on the criteria likely to be used to trial new regimens. This is also a conservative assumption for impact of a shortened regimen and was used to explore the impact of treatment shortening only. We did not include non-inferiority margins and instead set the two regimens to be equivalent in their outcomes. To match the treatment outcomes, it was assumed that no mortality occurs in the final 2 months of the standard regimen, that the same proportion of patients starting treatment were cured at either 6 months (standard) or 4 months (new), and that the proportion of those that default from treatment per month was the same. We assumed that at least two months treatment was required for any level of cure and that 3 months of the shortened regimen cured a greater proportion of the defaulters at 3 months than 3 months of the 6 month regimen (23% vs. 20%). The difference between the regimens is then that there are fewer defaults (due to those defaulting in months 5 and 6 of the standard regimen) and more of the early defaulters from the 4-month regimen are cured than from the standard regimen. This non-inferiority assumption results in relatively similar parameterization of outcomes during treatment (e.g. Fig 2).
The transmission model was calibrated across the 2004–2010 period. This is the base case scenario that then diverges into three baselines from 2011 to 2035. These three baselines are included to account for different analytical viewpoints–what would be the impact of a shortened regimen if guidelines were adhered to perfectly, or if we achieve our policy aims or if we continue at current levels of adherence? The three baselines are: “Guidelines” (assuming all existing TB and TB/HIV treatment guidelines are adhered to at 100%), “Policy” (assuming policy level coverage targets are achieved for TB and TB/HIV treatment where available or optimistic levels are assumed [1,33]) and “Current” (assuming maintenance of most recently measured coverage). The details of these baselines are given in Table 1, where it can be seen that TB control will be best in “Guidelines”, then “Policy”, then “Current”. The reference baseline was the “Policy” baseline.
The shortened 4-month regimen was introduced in 2015 with a rapid scale-up (see Fig B in S1 Appendix). This scale-up means that after 3 years 70% would receive the new regimen, after 5 years 80% and by 2025 under 10% of patients would continue to receive standard treatment. The impact of the shortened 4-month regimen is compared against continuation of use of the standard regimen in each of the three baselines across the 2015–2035 period. 2035 was chosen as the end date as it is a key deadline in the WHO Global Stop TB strategy .
We focused on exploring scenarios that would have a large impact on our results, instead of investigating the small effects with a wider probabilistic sensitivity analysis that would have been computationally expensive with this type of model. Alongside our three baselines, a range of key scenario analyses was explored in the reference “Policy” baseline. Previous work has shown that levels of default drive much of the impact of shortened regimens [11,12]. We considered three levels of default: 1.5% (in “Guideline” and “Policy” baselines), 8% (in “Current” baseline) and 30% in a high default scenario analysis. Background levels of resistance could also affect regimen efficacy. Hence we also considered the impact of a high initial resistance level of 20% MDR in treatment-naïve patients. A further scenario matches previous modeling analysis  by assuming that treatment must be completed in order for cure to be achieved.
A separate analysis explored our assumptions around resistance dynamics. Instead of assuming constant levels, we considered the impact of a shortened regimen if MDR-TB levels quadrupled, by linear increase, in treatment-naïve patients by 2035.
Costs were included from local patient and health system surveys (Table 3, [6,7,14]). Due to differences in adherence to TB treatment guidelines and therefore service utilization, the “Current” baseline had lower levels of patient and health system costs than the other two (“Guidelines” and “Policy”). Future values were discounted at a rate of 3% per year. Diagnostic costs were included for those with and without TB, assuming that an additional pool of possible TB patients were screened other than those on treatment with different coverage of GXP by different scenarios (see S1 Appendix). ART costs were also sourced from local patient and health system surveys [35,36].
The number of Disability Adjusted Life Years (DALYs) accumulated in each scenario was calculated using the standard formula with age weighting, with disability weights for TB cases that are HIV positive of 0.399 and for HIV negative 0.331 . Using random sampling over a uniform distribution of the costs, the cost at which the cost per DALY averted, i.e. the incremental cost effectiveness ratio (ICER), was equal to a given willingness to pay (WTP) threshold from a societal perspective was calculated. This threshold cost includes the (here unknown) price of the drugs used within the regimen, plus the cost of other operational changes such as drug susceptibility tests required in order for the regimen to be used. The range reported is then linked to uncertainty in costs only. The time frame for the DALYs was 2015–2035. Three WTP thresholds were used, a quarter, a half and the 2015 full Gross Domestic Product (GDP) per capita in South Africa ($6,618) [38,39] (see S1 Appendix for details of this calculation). These calculations were performed with and without ART costs.
Our primary outcome was the percentage of TB disease burden, deaths and DALYs averted by replacement of the standard first-line treatment with a shortened non-inferior 4-month regimen. Here TB burden was defined as the number of person years with TB disease. The price of the shortened regimens is currently unknown. Hence we focus our economic analysis on the threshold cost at which the regimen would be cost-effective at three WTP thresholds (1 x, ½ x & ¼ x GDP).
Epidemiological and cost impact
The model predicts that, with a “Current” baseline and continued use of the standard regimen, there could be 6.4 million person years with TB disease and 2.1 million deaths in South Africa between 2015 & 2035 (Table 4). Using a non-inferior 4-month regimen in South Africa results in a 1% reduction in this TB burden in the “Current” baseline (Table 4). With a “Policy” or “Guideline” baseline, the impact was negligible (Table 4, Figs C & D in S1 Appendix).
Epidemiological impact is estimated from the total estimated TB burden across 2015–2035 for predictions using the standard 6-month regimen (Std.) versus introduction of a new 4-month regimen (New) with no discounting. Also given is the percentage change from predictions using the standard regimen to use of the new regimen. The cost impact is given in terms of the patient (Pat.) costs averted (non-discounted) and the cost-effective 4-month regimen cost at three willingness-to-pay thresholds (multiples of GDP) using discounted values. The range reflects uncertainty in the costs. NA represents an invalid cost-effective cost not determined due to a lack of difference in impact or to it being negative. * This has units of person years with TB disease.
The impact on patient costs due to the introduction of a shortened 4-month regimen was estimated to be more substantial (Table 4). Up to 20% of total patient costs could be averted in each of the three baselines.
Comparing across the three baselines (Table 4), it can be seen that the biggest TB burden was estimated to be in the “Current” baseline, with a lower burden in the “Policy” and then “Guidelines” baseline, as would be expected by the level of TB control. The epidemiological impact of the shortened regimen is also greatest in the “Current” baseline, compared to a negligible impact in the other two baselines.
New regimen cost threshold for cost-effectiveness
The average monthly cost for the 4-month regimen at which the cost per DALY averted was equal to South Africa’s 2015 GDP per capita ($6,618) was $436 [NA, 5983] (mean [range]) for the “Current” baseline (Table 4). This results in a mean cost of approximately $14 per day. At costs below this threshold the regimen would be cost-effective and even cost-saving. A cost-effective regimen cost could not be calculated for the other two baselines as the difference in the TB burden averted was not sufficient.
As the willingness to pay (WTP) threshold decreases the maximum cost at which the 4-month regimen would be cost-effective decreases (Table 4). When the costs of antiretroviral therapy (ART) are included, the regimen cost decreases slightly (Table D in S1 Appendix). The differences in total patient costs when ART costs are included are negligible (Table E in S1 Appendix).
The impact of the 4-month regimen remained similar in all scenarios explored, with no scenario causing the impact to increase to more than 3% (Table 4). The largest rises in impact were due to increases in the level of default and assuming that there was no cure until treatment completion (Table 4). If default increased to 30% in the policy baseline the shortened regimen could prevent 2% of person years with TB disease and the cost-effective cost would increase to $978 [NA, 5919] (Table 4). Similarly, if it was assumed that there was no cure until treatment completion then 3% of the TB burden could be averted with a predicted cost-effective cost of $991 [NA, 9300] (Table 4).
If the initial level of MDR-TB in treatment-naïve individuals increased to 20% in a policy baseline, then the impact of the shortened regimen increased marginally to 1% with a new cost-effective cost of $622 [NA, 7493] (Table 4). However, increasing the level of MDR-TB in treatment-naïve individuals over time resulted in no change in impact compared to assuming a constant level (Table 4).
Using a detailed mathematical model fitted to the TB epidemic in South Africa, we found that introducing a 4-month first-line TB regimen would have a modest impact on the number of person years with TB disease and number of TB deaths over a 20-year period. However due to the patient costs averted, it is likely that such a regimen could be highly cost-effective.
Our results suggest that the epidemiological impact of the introduction of a 4-month regimen would be approximately 1%. In general, this is due to the low indirect impact on M. tuberculosis transmission: those who start TB treatment become non-infectious within 2 weeks of treatment [20,21] and hence the majority of transmission is occurring from those outside of the cohort starting treatment. We assumed that the regimens were equivalent, in that the same proportion completing treatment were cured, that the similar relative proportions were cured over time (e.g. percentage cured at completion of 75% of regimen was the same), but also that the same proportion of cases defaulted from treatment each month. Thus the epidemiological impact of the shortened regimen is linked to the proportion of cases defaulting from treatment in months 5 and 6 of the standard treatment that were not cured, that would most likely have been cured by the shortened regimen (as they would have completed 4 months of treatment). In our analysis, as has been seen in previous models [11,12], varying this level of default did alter this impact, but here only marginally. This, and our other scenario analysis, suggests that this impact, albeit modest, of regimen shortening is robust.
A shortened regimen could potentially have a large impact on patient costs due to the reduction in time spent attending health clinics and taking treatment. These costs drive our results that a 4-month regimen is likely to be cost-effective from a societal perspective. The provider cost savings however are likely to be relatively small compared to patient cost savings and hence policy makers in South Africa may further wish to consider affordability. This is because these patient savings cannot be converted directly into resources to fund health care and the purchase of drugs, and the two months treatment shortening is from the continuous phase, when healthcare provider costs are relatively low. The threshold costs that we found should also be seen as relevant for drug pricing, but if necessary should include the costs of new diagnostic tests for resistance that are likely to accompany the introduction of a new regimen. Some treatment shortening regimens may include compounds new to TB treatment and thus not in the current diagnostic repertoire for resistant TB and these costs would be incremental as part of regimen introduction. With the inclusion of ART costs, the total costs increase dramatically and mask the slight differences in TB costs due to introduction of the 4-month regimen.
Comparing results between baselines it can be seen that adherence to TB and HIV treatment guidelines affects the epidemiological impact by pushing it to negligible with small levels of default (for “Policy” and “Guideline”). With higher adherence to guidelines however, a shorter regimen has a bigger impact on patient costs averted. Note that both the health system and patient costs are lower in the “Current” baseline. This suggests that a shortened regimen would have less of an epidemiological impact in a setting with existing high levels of TB control, but could avert a significant portion (~20%) of the patient cost burden.
Previous modelling work has estimated the impact of shortened regimens, although, to our knowledge, not with this specific linking to a setting. Our estimates were lower than previous modeling results [10–12] for several reasons. Firstly, we assumed that partial treatment can result in cure. This will act to decrease the impact of averting default via shortening treatment. In our scenario analysis we assumed that cure can only occur at treatment completion, as in  and found an increased impact of introduction of the shortened regimen. Secondly, we assumed that the shortened regimen was non-inferior, based on the current trial designs currently being used for new TB drugs. Hence the same proportion of patients starting treatment died during treatment, as opposed to previous work [11,12]. Thirdly, we considered a time period for impact of 20 years (2015–2035) (shorter than ) across which continuation of TB control measures meant that incidence was declining and hence potential impact would decrease over time as opposed to assuming constant equilibrium incidence . Fourthly, we assumed a scale-up of introduction of the 4-month regimen resulting in a delayed, more realistic impact than straight replacement as first-line therapy. As our scale-up was relatively rapid, it is unlikely that a shorter scale-up that still captures operational realities (i.e. not a straight replacement), would significantly alter our results.
The limitations of our modeling relate to uncertainty–both in our limited analysis of it and in future levels of control and resistance. However, our scenario analyses revealed the results, around the small impact of a regimen shortening, to be robust. Specifically, we did not include the most recent South African ART initiation guidelines–hence we may over predict levels of HIV and hence TB disease in the future. However, as we considered the relative impact of changing TB treatment and our cost-effectiveness results are driven by TB treatment costs not by ART costs (Table E in S1 Appendix), we would not expect this to have a large impact on our results. A limitation of our model structure was that whilst rates of developing TB in those with HIV were modeled as depending on CD4 count, characteristics of TB disease, including typical duration and smear positive rates, depended on HIV status but not level of immune status (i.e. CD4 count). The limitations of our cost-effectiveness analysis are linked to uncertainty in future costs and prices. We thus adopted a threshold analysis. We also did not consider the continuation of indirect effects past our 2035 deadline and did not include regimen development costs, or the economic effects of increasing resistance. It should however, be noted that the extensive use of primary recent cost data is a strength of this paper.
The results of this work suggest that for policymakers adopting a new 4-month regimen would be an effective strategy due to the patient cost savings. We here investigated only the impact of regimen shortening, with the conservative assumption of non-inferiority. Any regimen shown to be superior, which would require a different trial design than has currently been utilized, would have a larger impact on TB burden. Similarly, if we had included margins of non-inferiority, i.e. allowed the shortened regimen to be better or worse within some range that still allowed it to be defined as “non-inferior”, the impact on TB burden would increase or decrease respectively. Future work could explore this threshold for cost-effectiveness, although our results suggest that even a slightly inferior regimen could remain cost-effective due to the patient savings from shortened treatment.
In conclusion, it is unlikely that a new shortened 4-month regimen would stop the spread of TB in South Africa with only a small impact on ongoing transmission. However, the costs averted for those with TB that are detected and enrolled on TB treatment would be large. These averted costs, which are dependent on levels of adherence to TB and HIV treatment guidelines, mean that new 4-month regimens are likely to be highly cost-effective in South Africa.
S1 Appendix. Supporting information on model structure and additional results.
We would like to thank the work done in estimating the costs for South Africa by N. Foster and E. Sinanovic.
Conceived and designed the experiments: AV RGW FC WW DD GK GG PD AZ. Performed the experiments: GK PD. Analyzed the data: GK RGW GG PD DD AZ WW FC AV. Wrote the paper: GK GG PD DD AZ WW FC AV RGW.
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domain: economics


text:
Тази тема беше архивирана. Моля, задайте нов въпрос ако имате нужда от помощ.
How do I edit the current theme?
Firefox colour addon removed the whole existing theme, replaced everything with it's default selections.
I use a custom theme, I just want to change the text colours on the menu bar, tab bar and bookmark bar. But the color addon destroyed the whole theme when I made any single change. I had disable and enable the theme to restore it. How do I import the theme to color addon so I can edit it?
Променено на от James
Всички отговори (1)
I'm new to this color extension stuff, but I think you just have to go your custom backgrounds that you saved in the extension when it was running. You will have all your own themes in that part...unless you didn't save it. Good luck!

domain: artistic


text:
Sweeter Side Of Love - Poem by zackery geddies
Not one but two hearts are beating
Together here in this lonely world.
I could count the breaths she takes
Here as we sit arm in arm.
So ask me if I've seen love and I'll say
'Yes it has a sweeter side'.
Although love can be a time bomb
I'll hold her close to heart.
Falling asleep while I'm writing for her
It doesn't matter she doesn't have a clue.
Melodies on the guitar strings
Give me some time I'll learn it.
It's the words that are important any way.
I'm not drunk
Maybe a little dizzy
But it's not the shots it's you.
There's a dream that was deferred
But I'll follow it anyway.
Once lost I was deterred
But I found you now we're here to stay.
So give me the sweeter side of love.
Give me what I deserve.
It's cold here inside of my room
But I've got you to hold on to.
It blew a light.
But it don't matter.
Give me the sweeter side of love.
And I'll be sure to be thankful.
There's no question or a doubt
That I can't go on living without it.
Pandora's box is open wide.
But darling don't fear it.
So give me the sweeter side of love and we`ll be just fine.
Comments about Sweeter Side Of Love by zackery geddies
Read this poem in other languages
This poem has not been translated into any other language yet.
Still I Rise
The Road Not Taken
If You Forget Me
Edgar Allan Poe
Stopping By Woods On A Snowy Evening
I Do Not Love You Except Because I Love You

domain: literature


text:
New Delhi: ICICI venture firm, RFCL Ltd, today said it will acquire Chennai-based veterinary healthcare firm Alved Pharma and Foods Pvt Ltd for an undisclosed amount.
RFCL has signed a definitive share purchase agreement to acquire Alved Pharma, which would see transfer all key people, assets, all contracts including exports and the brand name, the ICICI Venture firm said in a statement.
“Alved is a market leader in South India with significant export business to Middle East and Africa and is expecting to close FY08 with Rs18 crore sales revenue,” RFCL said.
The company said that this acquisition complements the animal healthcare business of Vetnex, the veterinary wing of RFCL, in terms of product profile and distribution network.
“We see significant upsides arising out of the synergies between Vetnex and Alved, which will augment the projected growth at a CAGR of 20% plus for the next 4-5 years for a consolidated animal healthcare business,” RFCL Ltd managing director Sushil Mehta said.
RFCL expects the animal healthcare business of Vetnex to close at Rs90 crore for FY08, with a growth of 22% over FY07. “Combined with sales revenue of Alved, RFCL’s veterinary product portfolio will be in excess of R 105 crore and would be a clear ‘No 3´ in the animal health industry,” it said.
Last year, RFCL had acquired Wipro Biomed and Godrej Medical Diagnostics. “RFCL will keep pursuing this strategy of strong inorganic and organic growth initiatives to keep increasing its base and geographical presence, across all its business domains in an attempt to build a reputed global life sciences and laboratory solutions company,” ICICI venture director (Investments) and RFCL chairman Aluri Srinivasa Rao said.

domain: news


text:
Spaced OutAudiobook CD - 2016
Theres nowhere to hide on the world2s first moon base. After all, it2s only the size of a soccer field. So when Nina Stack, the commander of Moon Base Alpha, mysteriously vanishes, the Moonies are at a total loss. Though he may be just twelve years old, Dashiell Gibson is the best detective they2ve got. But this confusing mystery pushes Dash to his limits. Especially since Dash accidentally made contact with an alien and has to keep it a secret. With the fate of the entire human race hanging in the balance, will Dash be able to solve the mystery of the missing Moonie?
Publisher: New York, NY :, Simon & Schuster Audio,,
Description: 6 audio discs (approximately 6 hrs., 45 min.) : CD audio, digital ; 4 3/4 in
Copyright Date: ℗2016
Branch Call Number: jSWCD Gibb

domain: library


text: It is a disabling and painful condition which can lead to substantial loss of mobility due to pain and joint destruction. I really liked the Arava, but I I am now on MTX and Simponi now. The disease is also systemic in that it often also affects many extra-articular tissues throughout the body including the skin, blood vessels, heart, lungs, and... I was on the Orencia when I was on the above two you mentioned. Generic plaquenil uses Can i get plaquenil in australia Can plaquenil cause itchy skin 5 line raster oct plaquenil Feb 29, 2008 I had a lot of problems with Methotrexate as well, but I am not having the same issues with arava which I was afraid of. The plaquenil worked wonders for me and I took it solo for about 2 years, but after a while I was starting to have a severe flare that wouldn't let up - so we gave it a push with the Arava. i'm doing quite well with the. I was diagnosed with RA 2 years ago. Started off taking methotrexate, plaquenil and a round of low dose prednisone. Did well until side affects of methtrexate became too much mostly nausea. My rheumatologist put me on arava and I've been doing well. Pain mostly hands, wrists, ankles & feet is mild to moderate but definitely manageable. Nov 01, 2018 CHICAGO – Combination therapy with leflunomide and hydroxychloroquine met all goals for efficacy, safety, and tolerability among patients with primary Sjögren’s syndrome in a randomized, placebo-controlled pilot study, lending support to evidence suggesting the two drugs have additive benefits. The doctor then kept me on my plaquenil and added Leflunomide (Arava) to replace the methotrexate. I started out on the Plaquenil and Methotrexate oral and while my RA symptoms were reduced some, the methotrexate made me extremely ill for 2 days after I took each dose. Arava and plaquenil together Evaluation of efficacy of combination of methotrexate and., Arava Drug and Medication User Reviews on RxList Is plaquenil used to treat lupusHydroxychloroquine sun skinHow to admin chloroquineChloroquine dose per kgWhat percent of people with arthritis benefit from plaquenil I have ra, am taking leflunomide 20 mg, prednisone 2.5 and plaquenil hydroxychloroquine 200 mg. I don't have in more I have ra, am taking leflunomide 20 mg, prednisone 2.5 and plaquenil hydroxychloroquine 200 mg. I don't have ins. Is it ok to take both prednisone and arava leflunomide for.. Leflunomide-hydroxychloroquine combo shows promise in primary.. Anyone with RA taking Enbrel, Plaquenil & Arava. Summary Drug interactions are reported among people who take Arava and Plaquenil together. This study is created by eHealthMe based on reports of 7,800 people who take Arava and Plaquenil from Food and Drug Administration FDA, and is updated regularly. Nov 16, 2017 Just wondering if anyone out there has been put on plaquenil and enbrel together. I noticed on webmed that the 2 should not be taken together as there is a serious potential interaction. I noticed on webmed that the 2 should not be taken together as there is a serious potential interaction. WebMD provides information about interactions between Arava Oral and leflunomide-warfarin. These medicines may cause some risk when taken together. Contact your healthcare professional e.g.

domain: medical


text:
Ekiti State Governor Hosts Interactive Session with Development Partners
The Governor hosted Development Partners in Nigeria to an interactive session where he made a Presentation on the Ekiti State Five Point Agenda opening up discussion on opportunities and areas of partnership and support to Ekiti State Government.
The meeting was designed to deepen and strengthen relationship with existing Partners and to form new relationship between the Development Partners and Ekiti State.
In attendance were 13 Development Partners namely:
- World Bank
- Bill and Melinda Gates Foundation
- French Embassy
- German Embassy (GIZ)
- Japanese Embassy (JICA)
The session arrived at clear outcomes and next steps were identified. These will form the basis of our follow up in order to deliver the benefits to the people of Ekiti that we serve.

domain: politics


The MEA-UWB-01-AM is a high efficiency cellular wide band LTE antenna for use with all 2G/3G and 4G LTE frequencies.
The MEA-UWB-01-AM is waterproof and rated IP67.
The MEA-UWB-01-AM is available with an SMA, FAKRA or customer specified connector and cable length.
The MEA-UWB-01-AM LTE Antenna – Low Profile Features:
2G/3G/4G Ultra-Wideband Automotive Antenna
Low profile for easy installation
Small size:105.1mm x 30.1mm x 6.7mm
Fully customizable cable length and connector
Designed for Automotive, Fleet tracking, IOT and Telematics


text:
WASHINGTON (AP) — The Trump administration is appealing recent rulings by a federal judge that blocked work requirements for some low-income people on Medicaid.
The rulings last month by Judge James Boasberg in Washington, D.C., blocked work requirements in Arkansas and Kentucky. The Arkansas requirements were already in effect, while in Kentucky they are a top priority for Republican Gov. Matt Bevin.
The Justice Department filed notice on Wednesday appealing to the U.S. Court of Appeals for the District of Columbia Circuit.
Arkansas is also appealing.
Boasberg had ruled that the Trump administration’s approval of work requirements for “able bodied” adults created numerous obstacles to getting health care that federal and state officials failed to resolve.
The administration argues that work promotes health, and officials say they’ll keep approving such requests from states.

domain: law


text:
Salba Tiger Reissue Santa Cruz Skateboards Deck Skateboard Green Blue Flame
Never gripped / set up / skated. This Salba Tiger Reissue deck from Santa Cruz Skateboards is perfect for skateboard enthusiasts who love a bit of personality in their gear. Featuring Steve Alba's unique personality and green blue flame design, this skateboard deck is a must-have for any serious skateboard collector. Made with high-quality materials, this deck is sure to provide a smooth and enjoyable ride for years to come. Whether you're a seasoned skateboarder or just starting out, this deck is sure to impress.


text:
Pousada Natur Campeche
Pousada Natur Campeche is a 3-star property situated about 12 km from Public Market. Since 1996, it has been hosting guests in the historical center of Florianopolis.
Pousada Natur Campeche is set near to the natural sandy beach.
This excellent hotel is placed within proximity to a lagoon and a lush garden.
The property has luxury rooms featuring individual climate control, an in-room safe, a minibar, a private balcony and a refrigerator. Bathrooms feature a shower, a spa bathtub and towels.
In the morning a buffet breakfast is served at the lobby. Guests can try delicious meals of local cuisine in the small restaurant onsite.
Hercilio Luz airport is 15 minutes' drive away from Pousada Natur Campeche.
The on-site bicycle and car rentals are also available.
On-site facilities for children include cribs, a play area and a game room. On-site activities feature diving, hiking and horse riding.

domain: travel


text:
KGD’s New Design Associate!
We are delighted to announce that Molly Cowart is a new Associate Designer for KGD! Molly recently graduated from Seminole State College with an Interior Design Degree. Her passion for interior design and architecture developed at an early age when she would watch her grandfather design and draft residential house plans.
She recently got married to her high school sweetheart, Adam. They both love spending time with their awesome dog named Ozzy – who was named after Ozzy Osborne. When Molly isn’t designing, she practices Lyra which is a type of circus acrobatics and dance performed on a large steel hoop that is suspended from the ceiling.
We are glad Molly has joined the KGD team!

domain: design


text:
Negotiations for the bus drivers union in the Easton Area School District will resume Tuesday, while similar talks should be scheduled within seven to 10 days for the secretaries union, according to school administrators.
The bus drivers, members of Teamsters Local 773, have been working under a previous four-year contract which expired June 30, 2005, while the secretaries union, the Educational Office Professionals of AFSCME District Council 33, Local 1893, has been unable to resolve bargaining issues since its contract expired on June 30, 2004.
With no discussion at Thursday's special board meeting, the school directors rejected, by a 5-3 vote, the latest proposals for a secretaries contract.
School Superintendent Dennis Riker said after the district and the secretaries rejected a fact-finder's report in November, it was back to the bargaining table in January. At that point, a mediator was recommended and his report was presented in the past few weeks to the secretaries and then to the school board on Thursday.
Riker said the mediator's report was rejected on many of the same issues that were disclosed in the rejected fact-finder's report.
While the mediator's report can't be made public because of continuing negotiating sessions, Riker said the fact-finder's report is public information.
In that report, the fact-finder noted that the 45 full-time secretaries earned $22,026 to $37,937 and five part-time secretaries made $9.86 an hour.
Riker said there has been some agreement on the issues, but he could not disclose them because that could be considered unfair labor practices.
Union representatives could not be reached for comment Friday.
Bus drivers union steward Helen Jones said the union had expected a negotiating session on Wednesday, but it was canceled by the district. Joseph Kish, assistant to the superintendent, said the board had received a union proposal from a negotiating session earlier this month. However Kish, a member of the negotiating team, was unable to present the proposal at an executive session -- which prompted the session's cancellation -- because of the many items slated for Thursday's school board agenda.
Contract negotiations are one of the few items school boards can discuss in executive session, but a vote on them must be made in public.
Kish said he did notify the union representatives on the negotiating team about the meeting cancellation.
The about 85 bus drivers and the school board also rejected a fact-finder's report in January. That report noted the district offered 3 percent annual increases in a five-year pact, while the union wanted 4.5 percent wage increases.
Kish said many of the issues in that report remain unresolved. That report said issues in contention included holidays, sick days, longevity pay and health benefits.
Kish said that mediator Robert Millett will participate in Tuesday's meeting.


Southwest Rapid Rewards Card from Chase recently surprised essential worker couples with a backyard pop-up honeymoon.
The “Honeymoon for Heroes” campaign also included giving out 1 million Rapid Rewards Points.
In partnership with Brides.com, Chase and Southwest created unique honeymoon experiences for five essential worker couples whose weddings and honeymoons were postponed due to COVID-19.
The events closely resembled their original plans, with couples enjoying Sonoma Valley-like scenes, decor reminiscent of a Caribbean oasis and camper-style setups.
Chase and Southwest took the time to get to know each couple over the past few months, so that they could design a pop-up backyard honeymoon experience that felt special and personal to their relationship.
Each couple also received 200,000 Southwest Rapid Rewards points (worth $3,000) that don’t expire, so they can take their real trip (or trips), when they are ready to travel.
The couples also qualified for Southwest’s Companion Pass through end of year 2021, which allows a Rapid Rewards member’s companion to fly with them free of airline charges every time they book a flight using points.
Each of the couples will have their own in-depth feature article on Brides.com at the end of the month in a custom content piece created for Southwest Rapid Rewards and Chase.
The companies that assisted with the activation were FleishmanHillard Inc. and MAS Event + Design, L.L.C..
As part of the campaign, Chase and Southwest also conducted a survey with Brides.com of over 1,000 individuals who are planning their honeymoons. Two-thirds of couples had to change their honeymoon travel plans this year. When they are able to reschedule, three-quarters of couples plan to stick to their original destination. The most popular destination is Hawaii.


text:
Window treatments inject more style into your home’s interior design, especially in the kitchen. The following kitchen window treatments could be just what your kitchen needs to add a bit more style to the space’s design.
- Cornice –The great thing about a cornice is that it won’t block any natural light. It’s main purpose is to add architectural interest. It also helps make your ceilings look higher, giving the kitchen the feeling of additional space.
- Valance – A valance is similar to a cornice in that it acts more as a decoration than a shade. However, it has the feel of a curtain since it tends to contain folds in the fabric, it just happens to be much shorter than one. A valance will go a long way to adding visual balance to the kitchen.
- Roman Shade – Roman shades are a fantastic option due to the fact that they don’t clutter up your window space, yet you can draw them all the way down to block light if you need to. This is in addition to the fact that they come in almost limitless patterns and colors to compliment your kitchen’s design with.
For more advice on kitchen window treatments as well as additional interior design solutions for your Atlanta or New Orleans home, contact me online at Susan Currie Design.


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Relocating to the United States can be a daunting task; learning American administrative procedures (such as opening a bank account) and for a home. In order to alleviate the stresses of relocating the aid of a company experienced in the country and located in it is indispensable. It is in this context that Alceis operates with its US partner. Therefore, the Human Resources Director is a reliable intermediary in the new country, encouraging saving time and money in the mobility management of the employee. Hand in hands in France and in the States, we are the preferred partner of the Human Resources Director for supporting the mobility of French speaking employees settling in the United States. We administratively and personally manage the transition in terms of installation integration into society across the Atlantic. Personalized monitoring is performed before and after the arrival of the employee. Relocation specialist in New York and Washington DC, we also draw our expertise from our dynamic team and their knowledge of French and American real estate markets.
A range of services to facilitate the arrival and installation
Our values are based on Trust, Competitiveness, Respect and Adaptability to customer needs. Our ambition is to offer all "the keys to a successful expatriation, fulfilling and peaceful." On the market of relocation since 2008, we offer support responding concretely to questions raised by expatriation such as:
Search for accommodation, rental or purchase,
- Organization of the move,
- Installation, for example providing a list with practical information of the expatriate’s new neighborhood,
- Administrative assistance, our consultants will wait for the expatriate and his family, in the long lines of executive departments of New York or Washington DC (driving license, identity card of the State, etc.. ), accompany visits to the Social Security office, bank, assisting insurance options, providing help from A to Z in all logistical processes or administrative installation to a new city,
- Education of children through their knowledge of the American education system, looking for a nursery or a nanny,
- Guiding expatriates, combining attentive and personalized service, tailored to their image,
- Social inclusion of a stay-at-home spouse through a formal relationship with the Francophone community in these cities (discovery of the culture, language, cooking, computer, etc.)
With our services, we shorten the period of adaptation and installation for families saving them the stress and expenses of changing country, having on-site listening and a contact always ready to intervene in difficult situations. We are an essential intermediary in the proper execution of this important transition to the new life as an expatriate both as an employee and as an individual.

domain: geography


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As some of my readers here know, I am crazy about TVB serials.
I watched (almost) every single one of the many serials they produced each year. But my own preference is always watching serials on the recent times (rather than those old times) as I can see places where I can visit when I go to Hong Kong. I have a very strong desire about visiting TVB locations. Very crazy right ? 🙂
Anyway, one of the serials which I like last year, 甜言蜜语, featured a road side food store (or what we loved to call 大排当) somewhere in Hong Kong. The main actress (yes, Kate 徐子珊 again) has a father that own a 大排当 selling great bread and drinks. The place looked very interesting and I showing you some screen shots from the TVB serial:
For example, we were introduced to 徐子珊’s character dad’s cafe:
In the TVB serial, the place is called 胜芳园 :
So I am quite curious. Is there such a place ? It looks real and does not look like shooting in the studio. Where in Hong Kong is this place then ?
Luckily, I slowly watch the whole serial a week before my Hong Kong trip on my computer and hence can pause the serial at appropriate moments and then do ny research on the internet.
In one scene, they finally showed the OPPOSITE ROAD of the location:
Wow. 2 clues. One is 九记牛腩 and the other is Halo Asia. That’s enough. Google and I found out that 九记牛腩 is a very famous beef store in Central.
Halo Asia web site is even better. It gave me the exact location and even a map of the store as in Gough Street.
Great. So now I know that there is actually such a street in Sheung Wan, Hong Kong. But is there such a store ? Is it just a flat empty place where TVB crew set up a store to sell food for the serial ?
So I visited Gough Street on my first day …
And the result was astonishing ! Really…. I will tell you in my next post but show you two pictures. One from the show and from the actual place
From the show:
(updated in March 2017 photo)
There is indeed such a place in Hong Kong.. And you can see in the actual place a great hint of the actual business at the place .. Tell you more in the next blog post 🙂
For those who are interested in GPS and stuff like that, the GPS Coordinates of the location is 22.284256, 114.152467. Enter that into your GPS tool or Google Map to help you find the place when you are in Hong Kong.


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Thursday, April 24, 2014
(Continued from page 1)
Merrimack River Painters, 11 women artists, Just us Chickens Gallery, Kittery. justuschickens.net. Through Oct. 31.
“Scenes from Maine,” gallery artists in a variety of media, Richard Boyd Gallery, Peaks Island. richardboyd artgallery.com. Through Oct. 31.
“A Life Imagined,” paintings by Mary Bourke, Greenhut Galleries, Portland. greenhutgalleries.com. Through Saturday.
“Focus on Faculty: Photographers from MMW+C,” 23 Maine photographers who have taught at Maine Media Workshops & College, PhoPa Gallery, Portland. phopagallery.com. Through Nov. 16.
“Aerials: Views from Above,” aerial paintings by Philip Carlo Paratore, Saccarappa Art Collective, Westbrook. 591-7300. Through Saturday.
“Scenes from Cuba,” photographs by Susan Downing, Kennebunk Free Library. kennebunklibrary.org. Through Oct. 31.
“Fallen Through the Cracks,” photographs by Lisa Crothers raising awareness about 14 million illiterate Americans, Wells Public Library. 646-8181. Through Oct. 31.
“Modern Mythology,” paintings, prints, photography, assemblage and digital works that blur the divide between painting and photography, by Maine Artist Collective artists, Constellation Gallery, Portland. constellationart.com. Through Friday.
“Persian Visions: Contemporary Photography from Iran,” with a video installation, University of Southern Maine, Art Gallery, Gorham. usm.maine.edu/gallery. Through Dec. 8.
Nancy Freeman, paintings and prints, The Gallery at Round Top Farm, Damariscotta. (888) 777-1077. Through Oct. 20.
“Drawing Matter,” Amy Stacey Curtis, June Fitzpatrick Gallery at MECA, Portland. 699-5083. Through Nov. 2.
Jeff Epstein, paintings exploring the intersection of the natural and man-made worlds, Art House Picture Frames, Portland. arthousepicture frames.com. Through Nov. 30.
Tom Baril, Eleanor Miller, Riv Pyne and Andy Rosen, photographs, paintings and sculpture, Susan Maasch Fine Art, Portland. susan maaschfineart.com. Through Saturday.
“Sticks, Stones and Bones,” group show of art from found materials, Aarhus Gallery, Belfast. aarhus gallery.com. Through Oct. 27.
“On Finding Home,” figures carved from wood and finished with painted surfaces by Sachiko Akitama, University of Maine Museum of Art, Bangor. umma.umaine.edu. Through Jan. 4.
“Waterfront Properties,” archival inkjet prints by Elke Morris, Glickman Library, USM Portland Campus, Portland. usm.maine.edu. Through Dec. 27.
“To the Ends of the Earth and Back,” historical overview of polar exploration and the process of globalization as depicted in maps, charts, books and artifacts, University of Southern Maine, Osher Map Library, Portland. 780-4850. Through Feb. 27.
“Three Graces for Environmental Awareness,” photographic project by Ann Tracy, Akari, Portland. 772-9060. Through Oct. 31.
“Along the Maine Coast,” acrylic paintings by Diane Noble, University of New England, Campus Center, Biddeford. 284-6394. Through Nov. 4.
“Hawk & Handsaw: Twenty Who Know the Difference,” selected works by 20 contemporary Maine artists who have been featured in Hawk & Handsaw, the journal of creative sustainability published by Unity College, Center for Maine Contemporary Art, Rockport. cmcanow.org. Through Dec. 1.
“Vittles,” six Maine artists celebrate food, 3Fish Gallery, Portland. 3fishgallery.com. Through Saturday.
“Something Small under the Blankets,” 4-inch-square editioned prints and monprints by 13 artists from central Maine, Circling the Square Fine Art Press Gallery, Gardiner. 582-2108. Through Saturday.
Morris David Dorenfeld, exhibition of recent tapestries, Icon Contemporary Art, Brunswick. 725-8157. Through Nov. 16.
“The Wonderful World of Oz,” exhibition drawn from the world’s most comprehensive collection of Oz materials, based in Maine, through March; “Every Picture Tells a Story,” N.C. Wyeth illustrations from the Brandywine River Museum, through Dec. 29; “A Wondrous Journey: Jonathan Fisher and the Making of Scripture Animals,” through Jan. 5; “American Treasures: Small Treasures,” through Dec. 29; “American Treasures: Other Voices,” through Feb. 2; “American Treasures: Visions of the Land and Sea,” through Feb. 2, Farnsworth Art Museum, Rockland. farnsworthmuseum.org.
Michael Shaughnessy, “3.2.7,” sculpture, Unity College Leonard R. Craig Art Gallery. 948-9239. Through Nov. 1.
“Things Seen III,” Kathleen Boldt drawings, collages and gouache paintings, Topsham Public Library Crooker Gallery. topshamlibrary .org. Through Oct. 31.
(Continued on page 3)


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This was originally planned to be a bit different... I'd decided that a cushion with a patchwork background and then an applique boat on the front would be just the job for Andy's birthday.
Can you see what's missing in this picture? Yes, I didn't put a boat on it. I'm afraid I fell more than a little in love with this machined patchwork and in the end I left it as it was.
The back is a simple envelope style as I didn't want to detract from the front. Next up a petticoat!


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|life or death|
Another little experiment today...
As I'd arrived home from work some 40 minutes earlier, I'd noticed that the stand of daffodils that bloom every Spring on the verge outside our garden are really opening up now.
We live at the edge of the foothill that runs along the North of Red Horse Vale, with Edge hill running parallel, a couple of miles to the South...I suppose if we lived those couple of miles south, we'd live at the foot of the Edgehill!
(aythengyew, I'm here all week...all year, in fact!)
Fun fact...the opening battle of the English Civil War was fought across the plain we live on the northern slopes of, in 1642. The centre of the battle was a couple of miles away over the fields, but by all accounts it was a bit of a disorganised brawl, with 1,000 soldiers killed and 3,000 more injured - there must have been a few of those up this way!
Bonus fun fact...up on the ridge above us was the old RAF Gaydon, whose airstrip, which runs for 2-3 miles from Gaydon to Kineton, was used at one time as a base for some of Britain's nuclear capable V-Bomber planes in the 50's and 60's...it's now a test-track used by Jaguar/Landrover and Aston Martin.
Anyway, the point is that the cold air seems to fall down the hill from up near the test track, and sits on the two little cottages in the corner of the arable field where we live...it's always a degree or two colder here.
This is borne out by the temperature gauges in our cars, which often show the temperature start to tick up by 0.5C within 100m or so of our little lane, in either direction, and as much as 2C by the time you get to Gaydon.
It's also borne out by the late flowering of our daffodils, which are spread liberally around our garden, and up and down the verge outside our garden too. I've seen daffodils flowering all over the place for a couple of weeks or more, around the rest of Warwickshire, but it's only in the last few days that they've really started to bloom here.
Of course, having noticed them and thought what a nice photo op they'd make, I promptly forgot all about it until getting home from walking Jazz, by which time it was nearly 7pm, and fully dark.
So I thought I'd see how the flowers responded to flash photography, and whether it might make an interesting and unusual shot. This is only about 15-20% of the daffodils that make up this stand, but it is the section that's flowering the most densely.
I like the effect of the colourful flowers against the dark night...I think it looks bright and lively.
Anna, on the other hand, thinks it looks like a cemetery!
This might seem somewhat bleak, on first glance...but this seems entirely a propos, today of all days...
An hour before this photo was taken, I was on the phone to my lil' bro' Jools. Our Big Sister Debs died in 2004, after battling the Big C for a couple of years. Today was her birthday, and she would have been 52.
Jools told me he was just picking up some flowers from both of us, and taking a trip to Debs' grave, in a natural meadow cemetery near Coventry.
So it was very much with Debs and cemetery in mind that I took the photo!
And Anna reads me so eerily well that she managed to glean cemetery from the resulting image, despite the fact that I'd uttered not a single word about any of that to her...spooky!
Still love you and miss you, Debs...


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How to Stop Being Jealous
"Love is not jealous, ... does not look for its own interests, does not become provoked."
Jealousy is when you react negatively towards the possibility of losing what you have to someone else. Unlike envy, it usually involves three people, rather than just two: you, the person who has what you want and the person who threatens to take it away. It's an unhealthy habit that can make any kind of relationship crumble; if you're a jealous person, you have seen how much damage it can do. But at the core of jealousy are some fears and expectations that are hard to shake, unless you make a conscious effort to cast them away.
Bite your tongue. When you feel jealousy taking over, don't react in a destructive way. Don't accuse, don't give the silent treatment, don't roll your eyes, and don't show any signs of displeasure. Try to do the opposite of what a jealous person would do. If a friend is going to spend time with someone else, for example, recommend a good movie or restaurant. If your partner is talking to someone else, leave them be. Do what a completely trusting person would do in your shoes, even if it makes you feel crazy. Jealous behaviour can bring any kind of relationship to its knees, so nip it in the bud. Make time to discuss, using nonviolent communication, what made you feel jealous later, when the strong feelings of jealousy have passed, and you're not as likely to overreact.
Recognise that jealousy is a self-fulfilling prophecy. When you behave jealously, you don't respond to someone's behaviour—you respond to what you believe someone's behaviour implies. In other words, you're reacting to a scenario in your mind that you fear, but that hasn't happened yet, and might not happen at all. By playing with another adult, for example, your child isn't doing something inherently wrong. Neither is your partner who calls to offer condolences to their ex whose mother just died. But your negative reaction to what you believe their behavior implies (that someone else is somehow better than or more important than you) will make the person feel defensive and paranoid, because they're being accused of doing something bad. The more defensive and paranoid they get, the more suspicious and jealous you get. It's a vicious cycle that's difficult to reverse.
Build self confidence. Jealousy is usually a by-product of insecurity and low self-esteem. Sometimes it's a deep-rooted fear of abandonment that someone will leave you, or withdraw their love or attention from you because you're "not good enough"—if so, you need to learn that other people's behaviour and lives are not a reflection on you. Confident people know that even when they are rejected or ridiculed, it's not always because they failed; sometimes people are just short-sighted. And even if they do fail, it doesn't reduce their worth; it simply means they need to learn something new.
Stop feeling entitled to all of a person's time. If you get jealous when you see someone you care about interacting with or spending time with someone other than you, then you need to consider "How much of this person's time do I really want?" It's understandable if you want to spend a certain amount of quality time with your partner, child, parent, or friend. If they're not spending any time with you, then your concerns are valid. But if they spend a good deal of time with you but you never feel like it's enough, and deep down you'd prefer it if you were together all the time, then it's not healthy. Find other activities, and other people to do them with, to fill your time.
Trust. If you get jealous easily, you've probably had your trust broken. Most of the time, the trust was broken in the past, and you inadvertently project your fear of being hurt again onto someone else. The question you need to ask yourself is whether this person (the person who you worry will hurt you) has ever done anything to break your trust in the past. If the answer is no, then it's important to give them credit for that, and not treat him or her like a criminal. If the person has broken your trust in the past, then it's time to forgive, or else jealousy will ruin the relationship.

domain: sociology


Hye Oozh hosts Vartush Mesropyan, Tatevik Ekezian and Marine Vardanyan (Photo by Paul Schlesinger/The Collegian)
Hye Oozh on Fresno State’s 90.7 KFSR-FM broadcasted a special episode dedicated to the 100th anniversary to the Armenian Genocide.
The radio station’s only ethnic program played patriotic music dedicated to Armenia and music related to the genocide alongside interviews with former host Sevag Tateosian and Barlow Der Murgrdechian, Armenian Studies Program coordinator and professor.
Students from the Charlie Keyan Armenian Community School also were invited into the studio to read poetry in Armenian and English.
Tatevik Ekezian, co-host and program director said that she was “hoping and praying every day and have for as long as I’ve known about the genocide for recognition, and we’re going to continue to do that.”
Ekezian spoke about the importance of teaching young Armenians about the genocide.
“You give your children your culture, their heritage, you never let them forget it,” she said.
“That’s the only way to survive and flourish and prosper, and, yes, one day we will get our recognition,” Ekezian said.
Tateosian was interviewed by Ekezian and spoke about his love living in the U.S., and it’s because it gives “us an opportunity to eat, work, put a roof over our head.”
“We don’t have to worry about some people with guns, the government coming after us,” he said, “moving us from our homes, marching us through the desert like the Ottoman Turks did in 1915.”
Der Murgrdechian said that every generation of students has to really find a way to communicate and give back to the community.
He said that it didn’t matter how students got involved.
“It doesn’t have to be related to the Armenian Genocide,” Der Murgrdechian said. “There’s a rich culture, language, arts, history and whatever you are good at doing, you need to give back to the community in those areas.”
Der Murgrdechian also discussed the unveiling of the Armenian Genocide Monument on Thursday and spoke about the energy of the night.
“If we could’ve captured the spirit and the emotion of that night and just say that we could spread it out for the next ten years,” he said.
“I think our Armenian community here, in Fresno and the San Joaquin Valley, at the end of that ten years, you’d see, just a transformed community.”
Marine Vardanyan, co-host of Hye Oozh, spoke about being a part of the radio program and particularly the centennial commemoration episode.
“Being a host of this show throughout the years and especially today as we commemorate the 100th anniversary of the genocide,” she said. “it’s just, I think I speak for all of them when we say it gives us more hope for the future.”
Vardanyan said that having the children from the Armenian school participate in the radio program’s centennial commemoration episode “gets us more excited for the fact that this will ensure that in the future, Hye Oozh will continue to be around.”
“We’ll have more students who will come and contribute their time and we’ll be able to impact the community as we have been doing,” she said.
Ekezian said that the radio program serves as a niche station to make sure the Armenian community in the Valley stays united.
“The important part of this is and it comes from our history and really, with the genocide in mind,” Ekezian said. “That we really were so close to extinction, and this is why we should stay united.”
“It’s not to say we exclude anybody else, in fact we include as many as we can,” Ekezian said, “but this is our way of staying united so we don’t lose that part of our culture and our heritage.”
Co-host Vartush Mesropyan talked about how a phone call from a loyal listener named Joan, who calls every Saturday, felt impacted by the genocide commemoration program.
Mesropyan said that Joan told her that she was “so emotional by hearing your program today, and I love it so much. It really touched my heart.”
“You know, it’s things like this that we have to, of course, bring the students in,” Mesropyan said. “Bring everyone in and just to show them that, hey, we’re still alive and no matter the centennial or just as an Armenian, as a person, we have to do everything we can to you know, to keep the Armenian culture alive in Fresno of course.”


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Elko, Nevada is a nature lover’s paradise and there are great places to explore or just relax. Doesn’t this fishing spot look inviting?
Bing Crosby at Binglin Stables, his thoroughbred race horse ranch in Moorpark in Ventura County, California...mid - a little bit of history Like us on Facebook!
Pepperidge Farm. Spring Creek / Elko Nevada
Nevada Northern Rwy - Ely Nevada


When Owner Goes to Jail, Pets Still Cared for
CAPE GIRARDEAU, Mo. - Dog owners know that their canines will stand by them, no matter what they do.
The law isn't always so forgiving. But when people are put in jail, police in southeast Missouri make sure their dogs are taken care of.
The Southeast Missourian reports police agencies in the region take a variety of steps to ensure the care of dogs and other pets after their owners are put behind bars.
Most contact relatives to pick up the animals. If none are available, the pets are typically taken to shelters or placed with veterinarians who care for them until a permanent home is found.
Perry County Sheriff Gary Schaaf says his officers might let animals stay with owners who are booked and released on minor offenses.


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Freitag, 31. August 2007
Welcome to my blog
I decided to create this blog to share with you interesting postcards or photos that I might acquire on ebay or other trading and auction places.
Hope you'll enjoy it. You are very welcome to leave comments and discuss details of photos with me.
To start with this postcard, it was used in 1916 and depicts a captured french Caudron G3 that was forced to land on 02-December-1915 in northern France and dismantled by the Germans.
Eingestellt von Kilian um 00:10

domain: history


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European Journal of Biochemistry vol:220 issue:1 pages:105-110
A low-molecular-mass zinc-containing protein was isolated by gel permeation and anion-exchange chromatography of lysates of human monocytes induced with zinc acetate. Characterization by sodium dodecyl sulphate/polyacrylamide gel electrophoresis and amino acid sequencing identified the two major charge-separable fractions and an occasionally occurring third fraction as metallothionein-1, metallothionein-2 and metallothionein-0, respectively. Metallothionein-1 was shown to consist of a mixture of isoforms, confirmed as metallothionein-1e, metallothionein-1g and metallothionein-11 by comparison with cDNA sequences obtained by screening a human monocyte cDNA library. We can find no previous observation in the literature of metallothionein-1g at both the protein and RNA level in a non-tumour cell, and of metallothionein-0 in a non-fetal cell or tissue. Since isoform-specific polymerase-chain-reaction amplification showed the presence of metallothionein-0 mRNA in zinc-induced but not in untreated monocytes, these cells can be used as an in vitro system to investigate the expression of this previously considered fetal isoform.

domain: chemistry


You’ve probably read all the gossip about Jennifer Garner and Ben Affleck by now. So you’ve come across those threads in which people tear down poor Jennifer and blame her for Ben’s alleged infidelity. In case you hadn’t read any of it, the rumor is that Ben Affleck cheated on Jennifer Garner with their younger nanny. We have no idea if any of it is true. And we’re sure if it’s true Jennifer dressing like hot slut every day wasn’t going to stop Ben from sleeping with the nanny if indeed he did. But that’s what some people are suggesting. They’re suggesting that Jennifer might have kept Ben’s eyes on her if she’d hadn’t turned into such a dowdy frump.
Here are some of the things you will come across in comment threads about Jennifer Garner and the way she has been dressing since becoming a mother:
- I think Jennifer Garner dresses like a slob to appeal to her Minivan Majority (via lipstickalley.com)
- Jennifer Garner dresses like a grandmother. I just can’t see Ben staying faithful to this woman (via Daily Mail)
- Jennifer Garner dresses like crap (via tomandlorenzo.com)
We’re sure Jennifer has read or been told about some of these comments but it hasn’t made her stop dressing the way she dresses. We’re guessing it’s because she couldn’t care less what people think.
But should she have cared a little more what her husband thinks?
Ask the Editor
If Ben Affleck did cheat on Jennifer Garner with their nanny, is it Jennifer Garner’s fault for getting old and frumpy?
Editor’s response: I’m sure if Jennifer Garner had it in her power to stop aging at 25 she would have gladly stopped aging at 25.
Are we really going to blame people for getting old? That’s not something anyone can help. As for blaming her for her husband’s choice to sleep with the nanny, if he did sleep with the nanny, excuse her for being too busy being a mom to her young children to worry too much about how sexy she looks or doesn’t look on a daily basis.
More than a few people think it’s a woman’s responsibility to keep her husband interested enough that he doesn’t stray. This means she must look sexy and act sexy all the time. Because that’s what she’s up against is a world filled with women who look sexy and act sexy. And it’s hard enough for her husband to resist temptation. When she’s going to be walking around the house looking like a frumpy old lady, she makes it harder for him to not notice and lust after all the sexy women around him.
But most men are going to notice and lust after the sexy women anyway. It won’t matter how hot their wives dress or how hot they act. And if a man is going to cheat he’s going to cheat regardless if his wife dresses sexy for him or not.
Preferring to dress comfortably is not a crime against your husband and your marriage. You don’t deserve to get cheated on because you wear frumpy clothes. So no, it’s not Jennifer’s fault for aging and taking on a mother-of-three style of dress. If Ben did in fact cheat on her with their nanny he did it because he wanted to–not because Jennifer drove him to it by not dressing sexy.


The White House faced growing pressure today over safety and health problems in the nation's nuclear weapon industry. The chairmen of five Congressional committees, and the Governor of Ohio, urged the Reagan Administration to resolve the safety issues before reopening two key weapon plants.
And a leading environmental group took the first step toward a lawsuit that could prevent restarting a nuclear reactor at the Savannah River Plant before assessing the effect on the environment.
Senior White House officials, however, dismissed criticism of how the Energy Department is managing the production and safety problems in the weapon industry and praised John S. Herrington, the Secretary of Energy, for his leadership.
The White House, according to a senior Administration official, does not view deficiencies in safety and significant problems in producing nuclear materials for the arsenal as a ''policy issue'' that requires White House attention. Called 'a Management Issue'
''Basically what we have at the moment is a management issue,'' said B.J. Cooper, a White House spokesman. ''The Energy Department is managing the situation very well. The President was briefed on all this by Mr. Herrington and others last week. You can't assume every time there is a problem, the White House sets up a special committee to deal with it.''
President Reagan is scheduled to visit Cincinnati, Bowling Green and Columbus Wednesday in campaign appearances on behalf of Vice President Bush. Michael S. Dukakis, the Democratic Presidential nominee, today visited with residents in Columbus who said they were concerned about uranium emissions from the Feed Materials Production Center in Fernald, Ohio. The White House is eager to keep the problems at the weapon plants out of the Presidential campaign.
A White House official who asked to be identified said the thinking among senior aides is: ''If the news is going to be really bad, don't you want to make it an Energy Department disaster rather than a White House disaster?''
But the Democratic chairmen of four House committees and a Senate panel that have jurisdiction over the Energy Department urged President Reagan to be more vigilant in managing the weapon production system. The Democratic Governor of Ohio, Richard F. Celeste, called on President Reagan to keep the weapon production plant in Fernald closed until a $600 million cleanup was completed. And the Natural Resources Defense Council, a New York-based environmental group, said today that the Energy Department would be violating a Federal law if it restarted any of three reactors at the Savannah River Plant, near Aiken, S.C., without completing an assessment of the effects on the environment and public health.
But C. Anson Franklin, Assistant Secretary of Energy for Congressional and Public Affairs, said his superiors did not intend to comply with Governor Celeste's demands on the cleanup of the Fernald plant. Mr. Franklin also said the agency did not intend to prepare an assessment of the plant's effect on the environment before trying to restart a reactor at Savannah River in January.
Mr. Franklin also declined to comment on the letter from the Congressional chairmen. Nuclear Arsenal Threatened
At issue is the ability of the United States to maintain its nuclear arsenal. It is becoming clear, Energy Department officials said, that political and legal activity by opponents is proving to be another burden for the aging and deteriorating nuclear weapon industry.