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Commoners were required to bow to them, and people were punished by death for stealing one. Breed: Pekingese There were 9 total, we have 6 ..Pyredoodle, Kansas » Towanda, This is toto mixed Pekingese pup needs a lovely home he's so cute very gentle all I ask i..Pekingese, Texas » Odem, This is mini me I call him that cuz he's so tiny he's also half Pekingese he's such an ad..Pekingese, Texas » Odem, This is Bailey she's now quite mixed with your niece she looks more like her mother beaut..Pekingese, Texas » Odem, I have three full blooded American Bulldog pups for sale with registration papers. Get reviews and contact details for each business including phone number, postcode, opening hours and photos. 2 years old; 12 lbs; Pekingese Llandysul, Ceredigion . They'll max out around 10 lbs. This advert is located in and around Kettering, Northamptonshire. READ IMPORTANT CHANGES UPDATE FEB. 2019. Below is a sample search of our Pekingese breeders with puppies for sale. Size: Small One boy and one girls only left!!! A wide variety of classified ads Buy, rent, sell and find anything - sleeve pekingese listings. Login / Register. ADULTS AVAILABLE For ADOPTION July 11th. NEW … An ancient breed, the Pekingese originated in China, where they were sacred companions to royalty.
sleeve pekingese puppies for sale in texas 2021

domain: pet


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Michael Vick just netted one of the biggest contracts in professional football, signing a six-year, $100 million dollar deal to keep playing quarterback for the Philadelphia Eagles. Vick is now the only player in NFL history to have signed two $100 million dollar contracts. As you’ll remember, his first contract – with the Atlanta Falcons [...]
After serving two years in prison for running a brutal dog fighting ring, Michael Vick got a second chance. But what happened to the dogs? In an update to our January story, we revisit the remarkable rescue and redemption of Vick’s former fighting dogs.
This week, we visit with parents struggling to maintain care for their developmentally disabled adult children in the face of budget cuts. Plus: where are Michael Vick’s dogs now? And: the Amy Chua phenomenon.

domain: news


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By Jeanne Neath
XX Amazons is setting out to snare liberals. Much of the power of the transgender movement comes from the support of liberals. Some of this liberal support is from liberal trans allies who are deeply immersed in the transactivist version of reality. But, many of the liberals supporting the transgender movement are barely informed about transgender ideology and have no knowledge whatsoever of what radical feminists and other gender critical folks have to say. Let’s call them “No Know Libs.” The No Know Libs don’t want to think through this difficult question. They just want to do the “right thing” and give their support to every minority group. They have been taken in by the line, “everybody knows transgender people are more victimized and oppressed than anyone else.”
Here’s where XX Amazons’ new quiz, “Do You Discriminate Against Transgender People,” comes in. Our quiz asks whether the respondent agrees with seven simple statements that almost anyone who is not a hard core transactivist or over-the-top trans ally would agree with. For example, the first question, written for heterosexual males states, “I am a heterosexual male and I have never dated and would rather not date ‘transwomen,’ especially if they still have male genitalia.” (See the graphics in this blog for more of the quiz questions or view a downloadable PDF file of the entire quiz.)The vast majority of people taking our quiz are going to agree with at least one of the quiz questions. When they find out (and they do find out because we tell them) that the transgender movement considers their belief(s) to be discriminatory, most people will experience emotional distress and a realization that there is either a problem with what the transgender movement is saying or with their own belief system.
Some could decide that their own beliefs are problematic and go the way of the devoted trans ally. That would be unfortunate. We believe that many quiz takers will be jarred into a willingness to start thinking more deeply about the problems with claims made by the transgender movement.
At the end of the quiz we do our best to lead No Know Libs into this questioning state of mind. We ask “What’s the score?” and say, “If you checked yes on any of these questions, then the transgender movement would say you are discriminating against transgender people. But is this really discrimination?” We point out that there is a conflict of rights between women and the transgender movement. We invite respondents to the XX Amazons’ website to find out more about the unexpected consequences of claims made by the transgender movement. We have enlightening explanations of the radical feminist viewpoint for each of the questions that should dispell any concerns they have about discrimination.Can we transform No Know Libs into the well-informed and questioning people we need them to be? These liberals are victims of the transactivist campaign to silence radical feminists and other gender critics. The “Do You Discriminate Against Transgender People?” quiz can help us help them begin to do some much needed questioning.
Here are some things you can do to help this educational process along. They don’t require very much effort or risk, but should get important thinking and conversation going. Start by acquainting yourself more with the quiz and give some thought to the explanations of the quiz questions. If you want, use this graphic or this smaller graphic to help spread the word about the quiz on Facebook or other social media.
Download the PDF file of the quiz and print copies. If you don’t want people to associate you with the quiz, casually put copies of the quiz out at locations like your public library, health food store or anywhere that has a place to set out literature. If you can risk people associating you with the quiz, give it to your friends or pass it out at events. People have a hard time resisting the chance to take a quiz. Use this quiz as a conversation opener and you can do your own educating about what is happening to women, girls and lesbians.
Postscript: XX Amazons is very interested in knowing about what kinds of responses you encounter when you distribute the quiz. Please let us know how it goes. We always like hearing from you and your feedback about the quiz will be very helpful. Thank you!

domain: sociology


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Top of the Hub
Now that we started going to St. Cecelia in Back Bay we spend more time downtown than we ever did. This Sunday we realized the kids had never been to the Tub of The Hub (restaurant at the top of the Prudential Center). There is an observatory, but instead of paying $50 for the family to go up there we had "special drinks" at the restaurant and took in the sites. So funny how the kids knew so many more landmarks then I did the first time I had been up there. They saw, "their school, their bridge, their parks!" My Boston kids!


This is the third in a series of posts spotlighting recently released email from Governor Tim Kaine’s administration. These posts are not meant to be comprehensive but to encourage further exploration in the Kaine administration records (electronic and paper).
Much of the Kaine email deals with public policy, legislation, and governing. Issues such as the state budget, transportation legislation, and the governor’s State of the Commonwealth Address garner wide media attention. But there other messages that focus on less publicized aspects of a governor’s administration: life and death decisions, grief, and remembrance. This week’s post focuses on, for me, some of the most powerful and moving email in the Kaine collection.
Tim Kaine opposes capital punishment. But when he ran for governor in 2005, he promised, if elected, he would uphold the law. Eleven executions took place during Kaine’s administration. The decision to proceed with an execution was not easy for Kaine. John Yancey Schmitt was executed on 9 November 2006. This brief exchange that night between Sherrie Harrington, Kaine’s confidential assistant, and Larry Roberts, Counselor to the Governor, that evening conveys this.
Capital cases also took a toll on Larry Roberts. A few days before the 10 June 2006 scheduled execution of Percy Lavar Walton, Marilyn Tavenner, Secretary of Health and Human Resources, reached out to Roberts. There was some question … read more »
Five years ago, Seung Hui Cho killed 32 people and injured at least 17 others before turning the gun on himself. The 16 April 2007 massacre at Virginia Tech is the deadliest shooting incident by a single gunman in United States history. In the immediate aftermath of the shooting, I created a web archive collection, Tragedy at Virginia Tech, in order to capture the Commonwealth’s “on-line” response. Included in the collection are the websites of Virginia Tech, the Office of the Governor, and the Virginia Tech Review Panel. I remember creating the collection because of the “historic” nature of the shooting. I confess that I initially viewed that day’s events with the emotional detachment of an archivist/historian. But what made it “historic?” The number of people killed? The 32 people who died that day are not numbers – they had names, families, hopes and dreams – a future. The biographies captured in the Tragedy at Virginia Tech collection quickly shattered my impassiveness. What I saw as “historic” in 2007 is an ever present tragedy for the families who lost their loved ones. It is a wound that time cannot heal.
I was reminded of this when I began processing the e-mail records of Governor Tim Kaine’s administration. The Kaine administration transferred to the Library of Virginia approximately 1.3 million e-mail messages from 215 staff … read more »


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Cellulose, cellulose gum, methylcellulose, and cellulose gels thicken and help to blend mixtures that might otherwise separate, such as oil and water mixtures. They are commonly used as alternatives to gelatin and gluten in vegan-friendly products. Cellulose comes from the cell walls of plants.
Caramel color gives foods and beverages color, ranging from yellow-amber to dark brown. It is made by heating sugars or starch, either alone or in the presence of acids, alkalis or salts, a process called caramelization.
Natural and artificial flavors enhance or add flavor to foods and beverages. Natural flavors come from natural sources such as spices, plants or animals. Artificial flavors do not come from the food normally known for that flavor. As examples, either synthetic lemon flavoring or flavor extracted from limes, used to enhance a lemon-flavored product, would be considered artificial flavor.
Definition provided by The J.M. Smucker Company
According to the FDA, the most common food allergens are milk, peanuts,
eggs, fish, crustacean shellfish, soy, tree nuts and wheat.
This product does not contain milk, peanut, egg, fish, crustacean shellfish, soy, tree nut or wheat allergens.
The J.M. Smucker Company is committed to complying with federal GMO labeling regulations, specifically the Bioengineered Foods Disclosure Act. These regulations will require labeling of foods that contain bioengineered (GMO) ingredients. Disclosure must be through text, a symbol, or a scannable code, such as a SmartLabel™ QR code. Once the government has fully developed the language and guidelines for labeling, Smucker will implement these requirements across all products with genetically modified ingredients.

domain: chemistry


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Tired of Alabama's cold weather? Take heart - it could be much, much worse.
Scientists said data from East Antarctica shows the area broke its own record for cold temperatures.
Scientists Ted Scambos from the National Snow and Ice Data Center said temperatures in the remote ice-covered region dropped to 135.8 degrees Fahrenheit below zero in August 2010. Then, in July 2013, the area posted a temperature of -135.3 degrees.
"I've never been in conditions that cold and I hope I never am," Scambos said. "I am told that every breath is painful and you have to be extremely careful not to freeze part of your throat or lungs when inhaling."
The old record, set in 1983, was -128.6 degrees, also set in East Antarctica. The coldest temperature ever reported in the U.S. was -79.6 degrees in Alaska.

domain: geography


The Zimbabwe Professional Nurses Union (ZPNU) has written to the Ministry of Health and Child Care seeking reforms and upgrading of nurses.
In a letter addressed to the Ministry’s permanent secretary and copied to the director of nursing services, ZPNU said they viewed Government’s lack of commitment to the upgrading of Primary Care Nurses as a violation of rights.
“We kindly ask your highest office to facilitate the upgrading of PCNs. Education is a fundamental right in terms of the Constitution of Zimbabwe. We view lack of commitment to upgrade PCNs as gross violation of rights of Primary Care Nurses to pursue their education as masters of their own destiny.
“We kindly advise the Ministry of Health to liberalize post basic training and ensure that nurses progress to degrees instead of hoarding diplomas. Offering of post basic qualification will ensure universal access to all nurses who want to upgrade themselves. The move will also address issues of nepotism and corruption around post basic training. Moreover, this upgrade will enable our nurses to meet world standards as they will be competitive,” said the nurses.
The union appealed to the Ministry to facilitate the issuance of Diplomas to nurses who have completed bonding.
“We are informed by our members that those who have already completed bonding are being denied access to their Diplomas. We kindly request your highest office to facilitate a smooth flow to the issuance of Diplomas, to those who have completed bonding,” ZPNU said.
According to the regulations nurses are trained free of charge for three years and are bonded for the same number of years before they are issue with their certificates.
Nurses who intend to leave the country have been seeking clearance from the Nurses and Midwives’ Council but to no avail with the council claiming that most of the applicants were ineligible because they did not meet requirements.


Iraq’s parliamentarians voiced their strong opposition to the US mediation between the Baghdad government and the Kurdistan Regional Government (KRG), and warned Washington to stay away from Iraq’s problems.
“The Americans cannot solve Iraq’s problems, because during their nine-year presence in Iraq they showed that they cannot do anything or solve any problem in such a way that they have left behind thousands of problems for Iraq,” an Iraqi parliamentarian and one of the leaders of the Iraqi Kurdistan’s Coalition Mahmoud Osman told FNA on Monday.
He urged Iraq’s political parties to start talks in a bid to resolve the country’s problems.
Osman also stressed that the Turkish government should be held responsible for the problems affecting Iraq’s Kurdish region.
“On one hand, Turkey provokes Kurdistan against Iraq’s central government and on the other, it instigates the central government (in Baghdad) against the Kurds,” he added.
Another Iraqi MP, Eskandar Vetvet, told FNA that “Iraq does not need the US interference in its internal affairs, specially with regard to the Erbil crisis”.
Javad al-Bozoni, another Iraqi lawmaker, said that the US meddling in Iraq’s affairs doest not benefit that country, specially considering that the so-called crisis in the relations between Baghdad and Erbil is fake and not a genuine crisis.
He said the US left Iraq according to the will of the Iraqi people and thus its return to Iraq would be unacceptable because it would run counter to the will of the nation.
Last month, Iraqi Prime Minister Nuri al-Maliki rejected a proposal by US Vice-President Joe Biden for the deployment of the US forces in Iraq’s Northern province of Kirkuk.
Biden in a telephone conversation with Iraqi prime minister Saturday night asked for Maliki’s consent to the deployment of the US troops in Kirkuk, but the premier rejected the US vice-president’s offer, an informed source told FNA in Baghdad.
The source, who asked to remain unnamed due to the sensitivity of his information, said during the phone talk, Biden voiced concern about a recent clash between the Pishmerga forces of the Iraqi Kurdistan region, who are the local law enforcement troops of the Kurdistan Regional Government (KRG), and Iraq’s Federal Police troops, and said the US troops should be deployed in the oil rich Kirkuk province in a bid to prevent the outbreak of a civil war.
“But the Iraqi Prime Minister strongly rejected Biden’s proposal,” the source added.
Earlier this year in June, Iraqi Prime Minister Nuri al-Maliki cancelled a pending visit by the US vice-president to Baghdad, which was aimed at meetings with high-ranking Iraqi officials.
“Nuri al-Maliki did not allow US Vice-President Joe Biden to visit Iraq,” an informed source in the Iraqi prime minister’s information bureau told FNA in Baghdad in June.
Earlier reports by a website affiliated to the Islamic Supreme Council of Iraq said that the cancellation of Biden’s visit by Maliki was ordered after it had been revealed that the US vice-president was due to visit the Kurdish city of Erbil.


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Energy and Environment Segawa Laboratory
Department of Multi-Disciplinary Sciences,
Graduate School of Arts and Sciences
In our laboratory, next-generation high-performance photovoltaics over 24% PCE using organometalhalide perovskite have been investigated. Various basic researches on the new materials will open the door of frontier science and bring the future photoenergy conversion technology.
Dye-sensitized solar cells, quantum dot solar cells, and energy storable solar cells have also been developed.
Specialized field：Solar power generation, Perovskite solar cells, Hybrid solar cells


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page 24 - Dunsford Station
- Media Type
- Item Type
- (1943) Dunsford Station and GTR Station, Lindsay, Ont.
- p. 24
- Date of Publication
- Corporate Name(s)
- GTR ; Grand Trunk Railway ;
- Thurston Family
- Geographic Coverage
Latitude: 44.45012 Longitude: -78.64956
- Copyright Statement
- Copyright status unknown. Responsibility for determining the copyright status and any use rests exclusively with the user.
- Location of Original
- Original remains with Thurston family.
- Kawartha Lakes Public LibraryEmail
Agency street/mail address190 Kent St W.
Lindsay, ON K9V 2Y6


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Get lost in another imaginative and whimsical Little Nova adventure through the eyes and illustrations of her mother. Ride along on her journey as Nova learns the colors of the world around her as her mother tries to convince her that not every color is PINK!
Learning colors becomes an exciting and colorful escapade alongside Nova. Whether she envisions giant raining pickles, fashionable lady bugs, or taking rides on blue birds, Nova’s vivid imagination takes her to far off places where all things are possible and all dreams come true.
Not Every Color Is Pink, Nova! Board Book
2 - 5 years (appropriate for ages 0 - 5)

domain: library


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With cyber-security incidents increasing, GDPR scares and the Cambridge-Analytica crisis, data security is on everyone’s mind. UK consumers are expressing willingness to walk away from a business that fails to look after their personal data. From this, retailers are most at risk of customer loss.
According to the Cyber Governance Health Check, top UK boards still do not understand the impact of a cyber-attack. Here is a quick guide about why this might be and steps to improve this situation.
Blockchain is everywhere and research suggests blockchain will have an effect on the legal system in the UK. But, what is its impact on the legal industry? More importantly, will it affect your legal relationships?
As I am sure we all remember from last year’s GDPR rush, there has been significant progress in cyber security legislation from the European Union. But what has happened since then to protect us and our businesses?
There are two main fields of investment which have arisen as goals for the end of 2019: cloud migrations and moving away from Windows 7.
Since our 2018 Beyond the Cloud survey, Serviceteam IT have been interested in exploring the apparent skills shortage. We have written many blogs about the gloom UK organisations have faced in terms of tech industry employment. With Brexit, this has been heightened. But it appears that it is not all doom and gloom.
Currently, Gov.uk Verify (a digital ID system) developed by the Government Digital Service is a secure way to prove who you are online. You do not need to prove your identity in person to access government services, like filing tax or checking identification like driving licences. However, the future of this body is unclear and more public sector data should be available for effective identity verification.
The UK Government want the UK to be at the forefront of Artificial Intelligence (AI) and the data revolution. And why wouldn’t they? The economy still needs to thrive, and can be done through new and innovative forums.
Software developers are building new cloud-based software with such ease that there are warnings of future headaches for IT teams responsible for infrastructure and operations. A recent Gartner study found that by 2025, 70% of IT infrastructure teams will be unable to support the business. Only ¼ of IT Infrastructure leaders would have teams with the right skills and working practices to support the requirements for IT operations.
Blockchain has huge potential, but it seems no one knows what for yet. There are positive legal applications, security applications, insurance applications as examples, but few have seemed to apply the technology in a live environment.


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Law, Drugs and the Politics of Childhood
From Protection to Punishment
- Available for pre-order. Item will ship after March 30, 2021
This book examines how and why drug laws persist in the way that they do, and why particular populations benefit, or suffer, more than others. This biopolitical reading of drug control also provides a more theoretically coherent explanation for the centrality of race to disproportionate regimes of policing and imprisonment.
The work provides an abridged history of the association between drug control, childhood and race, considering this relationship from a biopolitical perspective. It problematises some of the reforms that have taken place in recent years, notably in respect of cannabis depenalisation in countries such as Canada and the US, suggesting that such measures continue to serve as securitization practices through which law and order responses to substance use remain paramount. In doing so, it asks whether reform initiatives justified on the basis of child protection rationalities are in fact such a significant break from the past. It considers whether depenalisation is either as unambiguously good, or definitely bad, as many observers would have it, but rather manifests the political choices and tensions lying at the heart of contemporary drug debates. Using analysis of sentencing measures for drugs offenders, the discussion then considers the ways in which rationalities of child protection serve to justify the incarceration of users and suppliers. The book subsequently turn to the question of parents, and particularly the ways in which drug-using mothers may be sterilised, incarcerated and otherwise stigmatised as a result of law and policy measures. The final chapters consider child drug users as agents, exploring the ways in which some children experience exclusion and discrimination as a result of school drug policies and criminal justice practices. Existing regimes of drug control that rely on imaginaries of childhood, it is argued, merely serve to cause harm to under-18s who use or supply substances.
The book will be essential reading for researchers and academics working in the areas of Criminal Justice, Law, Psychology and Sociology.
Table of Contents
2. Drugs and childhood: A genealogy
3. Drug law reform and the politics of childhood
4. Endangering childhood: Framing the drug pusher
5. Family Justice and child protection: Mums on drugs
6. Punishing children: Problematising school exclusions
Simon Flacks is Senior Lecturer, Department of Law, University of Westminster, UK.

domain: law


Asia’s Got Talent will receive some incredible star power when the new season kicks-off. Grammy-award winner David Foster, UK pop sensation and former Spice Girl Melanie C, Indonesian rock icon Anggun and Taiwanese-American pop idol Van Ness Wu have been named as the celebrity judging panel for the season premiere of hit talent search show, Asia’s Got Talent on AXN.
Billed as the biggest talent competition in the world, Asia’s Got Talent will light up screens across Asia in March on AXN and will feature some of the region’s most incredible performing artists as they compete to take home the coveted winning title.
Hui Keng Ang, Senior Vice President and General Manager, Sony Pictures Television Networks, Asia said, “We have put together a superb panel of judges for ‘Asia’s Got Talent’. This is definitely our most ambitious original series to date and is very much in line with the type of smart, high-quality local programming that audiences have come to expect from AXN.”
Paul O’Hanlon, Managing Director of FremantleMedia Asia said, “We’re proud to say that ‘Asia’s Got Talent’ will be the largest version ever of the Got Talent franchise, and our judges bring a depth and breadth of experience and talent worthy of this show.”
From thousands of applicants, the four judges must select Asia’s most jaw-dropping, mind-blowing, and breath-taking performances. Those who move on to the semi- finals will face an even more intimidating judge, the AXN audience at home who will ultimately determine who wins the first season of Asia’s Got Talent.
Adding to the excitement, the semi-finals and finale will be held at the iconic Marina Bay Sands, Singapore, with the winner awarded a contract to return and perform live at Asia’s leading entertainment destination.


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Hopystein cute monster created on . In this category have been added so far a total of 0-th games. Apple & Onion is a cartoon created by Q&A with George Gendi. In 2016 Cartoon Network USA have uploaded two animated pilots from their Studios
This category don't have active online games ! Try one random online game from our list.

domain: entertainment


If there was ever a time to harness the power of the spoken word to uplift and inspire young people, it is during Youth Month. And Vodacom struck the right note with its rallying cry for young people to strive for success and excellence, irrespective of their challenges and circumstance.
The well-respected blog Marklives even awarded Vodacom, Ogilvy Team Red and director Dan Mace of Egg Films #AdoftheWeek for perfectly capturing the voice of the youth in an authentic way and in a manner that will resonate beyond the month of June.
Using spoken word, to speak about harnessing the power of ironic understatement turning it around to fuel ambition instead of hinder it. It is quite simply an inspiring message about not allowing your situation to hold you back from reaching for your dreams and your full potential. The #TIYT campaign’s pay-off line, ‘This is Your Time’ has never been more appropriate than it is right now.
This is a sponsored post


In an era where the boundaries of free speech are constantly tested against the backdrop of public health and safety, the Supreme Court faces a pivotal case that could redefine the First Amendment’s reach in the digital age. The controversy centers on the government’s alleged pressure on social media platforms to curb certain speech during the Covid pandemic, raising critical questions about censorship and the role of private companies in regulating content.
The Intersection of Public Health and Free Expression
The onset of the Covid-19 pandemic brought about unprecedented challenges, not least in the realm of information dissemination. As health concerns mounted, so did the spread of misinformation, prompting federal officials to engage with online platforms in a bid to manage the narrative. This intersection of public health policy and free expression has now culminated in a Supreme Court case that scrutinizes the thin line between governmental guidance and unconstitutional coercion.
The case stems from actions taken by various federal officials who were documented to have been in contact with social media platforms regarding the removal or demotion of posts deemed as misinformation. The Supreme Court is tasked with determining whether such actions overstepped constitutional boundaries, effectively suppressing free speech through indirect means.
The Legal Quagmire of Digital Speech Regulation
At the heart of the legal battle is the complex relationship between the government and private tech companies. The latter, which wield significant power over public discourse, find themselves in a quagmire of legal and ethical considerations. The Supreme Court’s decision will have far-reaching implications for how these platforms moderate content and collaborate with government entities.
The arguments presented hinge on the interpretation of the First Amendment in the context of modern communication channels. The plaintiffs argue that the government’s involvement with social media companies amounts to censorship by proxy, effectively silencing viewpoints without direct legal action. The defense counters that no explicit coercion took place and that the platforms acted within their rights to manage content.
The Future of Free Speech in the Digital Arena
As the Supreme Court deliberates, the outcome of this case will set a precedent for the future of free speech online. It will influence how governments interact with private entities in regulating speech and could redefine the responsibilities of social media companies as arbiters of public discourse.
The decision will also reflect on the broader societal values regarding free speech and public health. It will either affirm the government’s role in combating misinformation during crises or underscore the sanctity of free expression, even in the face of global emergencies.


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What EXACT V13 can do for your dental practice
Built on years of analysis and research, EXACTV13 Dental Practice Management Software gives practices the management tools to maximise profitability and improve patient outcomes.
EXACT V13 dental software automates many of the mundane but essential management tasks that collectively determine the financial success of a dental practice. It includes a range of features that allow dental practices to benefit from increased efficiency, giving you more time to focus on patient care.
Making a significant difference to practice performance EXACT V13 dental software organises the protocols in which a practice is run and improves the key performance indicators that determine long-term success.

domain: medical


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Medication for ADHD falls under two major categories: stimulants and non-stimulants. Stimulants belong to the emblem names of modafinil, modafinil, Concerta, Dexedrine, Focalin, Metadate and Vyvanse. What these medications “stimulate” may be the dopamine from the brains of an individual with ADHD, which rebalances the deficit on this neurotransmitter that typically exists and results in the ADHD symptoms. Common non-stimulants used inside treatment of ADHD belong to the manufacturer names Strattera, Wellbutrin, Effexor, Clonidine and Intuniv. These act on other neurotransmitters either from the brain and the body and therefore are consideration to indirectly minimize the ADHD symptoms.
Before we are able to find out modafinil positives and negatives we must know very well what it can be. modafinil generally known as methylphenidate is usually a stimulant produced by a similar family as cocaine. modafinil, like other stimulant medications, sticks to raising the manufacture of neurotransmitters, for instance dopamine and norepinephrine, inside the brain. There actually are bad and good sides to modafinil use that you need to understand. You can find many places to buy Modafinil online safe and fast !
Prescription painkiller abuse is booming in the United States. According to the U.S. Drug Enforcement Administration, over six-million Americans abuse medications, a startling number considering these drugs cause a lot more than 26,000 fatal overdoses annually, says the Centers for Disease Control and Prevention. Even youngsters are abusing medications, with 1 in 10 teenagers admitting to getting painkillers for instance Vicodin and Codeine.
People use painkillers to ease their pain without losing consciousness, mostly decide to buy Fioricet or similar. Typically, the 2 major groups of painkillers are non-narcotic and narcotic. Teen painkiller addiction involves both these painkillers. Non-narcotic have ended the counter drugs, but they also can be medications. Narcotic drugs are normally used limited to chronic illnesses, or fond of those who are injured or even cope with a surgery. Opiate painkillers are commonly abused, including Demerol, Vicodin, Codeine and Oxycontin. Within the past number of years, it is often reported that there would be a forty percent boost in the abuse of Oxycontin during 3 years.
Osteoarthritis or “wear and tear arthritis” is definitely that, sort of wearing away from the joint. It usually occurs as our bodies age OR after many years of running or wear on the joint. I can’t show you the quantity of folks figure out “The orthopedist said the disc inside my neck or mid back is worn down as a result of how old irrrve become.” My fact is “Well, what age include the other discs inside your spine?” Obviously, I see more of these problems from the spine since the spine may be the focus of my practice being a chiropractor. DJD or osteoarthritis within the spine, is generally the consequence of (or several) bones from the spine who are not in perfect alignment. And just like your vehicle being outside of alignment, these areas tire out quicker compared to the rest in the spine. The discs wear away plus the wisdom from the body attempts to stabilize the location. On x-ray, this reaction appears to be little bone spurs. It’s actually the entire body looking to fuse these vertebrae so that you can protect you. Usually, the catch is not noticed before disc is approximately gone along with the spurs (or osteophytes) learn to press on nerves, causing pain.
Nearly two-thirds of folks in prescription drug rehabilitation programs say these people were physically or sexually abused as children. Studies are finding a great number of that are suffering from painkiller addiction are with your drugs to numb a “different” sort of pain, that relating to emotional turmoil.
Governor Rick Scott has vowed which the state’s efforts to curtail prescription abusing drugs continues. Scott reports which the sale of Oxycodone is down 17% at pharmacies from the first five months of 2011. There’s no guarantee this statistic will always be consistent all year round, however it is promising.
Tramadol can be a FDA approved drug, listed in the sounding analgesics or opioid agonists. The drug acts about the nervous central system, being 100% synthetic and it also doesn’t need the slightest structural similarity with opiates. It has been associated with opioids since it generates vertigo, somnolence, nausea and sweating in excess, much like narcotics. The actions of Tramadol are viewed as to become reduced as compared to opioids, including in relation to allergic as well as other complications.
A veterinarian on the Elizabethtown Animal Hospital became concered about 23-year-old Heather Pereira, after she stumbled on the clinic to get a third time, in ninety days, back with her four-year-old golden retriever who gave the impression to have endured cut injuries. The most recent incident happened on December 4. After the authorities were alerted, Pereira allegedly admitted that they had used a razor to injure her dog so that you can have the narcotic pain killer online Tramadol.
The experience has not been the very best really and I constantly felt sick together problems getting out of bed from the mornings through dizziness. I figured there were much more for this drug compared to the doctor who prescribed them was letting on…….and I was right! The Dangers of Tramadol There are almost no recognized perils of Tramadol when you stick from the recommended dosage levels. The problems arise if the pain is so bad you set about taking over you need to!
With other medications, like one for hypertension, some month’s refills occur a few days early when it is in other months the sufferer refills the medication a couple of days following your one month mark. There is a balance that takes place. Rarely is that this true with controlled substances. Every month is early. Your Intrepid Pharmacist would not be thrilled if only once someone would actually drop their cholesterol medication down the sink or perhaps the bathroom .; it will always be the controlled substance fitting basic a finish. Nor has he yet to have early refill argument over consistent early refills of any hypertension medication.
Today, Online Pharmacy will be here to offer you the answers you happen to be searching for as convenience in ordering pain medication. You can order pain medication online with big discount although you will have to choose the right pharmacy to your requirements. You just need to ensure you pick the right company ‘ check their privacy along with their website security before you purchase any provider.
Ambien drug has become developed for the short term treatments for insomnia. It has a tendency to raise sleep duration and lower sleep latency. Ambien may be taken by mouth on empty stomach immediately it is usually to bed or as instructed by way of a doctor. The drug is usually used by short spans of their time around 7-10 days. Ambien really should be taken just as instructed; you should not enhance the dosage or apply it for a longer time than recommended. You should also not begin or stop using Ambien drug without pharmacist or doctor’s approval.
Treating Insomnia With Sleep Drug Ambien
Coping with a sleeping disorder is usually a relentless cycle of restlessness. Rather than concede on the frustration of insomnia, others test out a cornucopia of insomnia vitamins and therapies. From Ambien pills online??, cognitive behavior therapy (CBT) to melatonin and also other insomnia vitamins, research suggests that sufferers possess a slew of effective and useless options that they can.
Ambien is often a schedule VI drug as defined by the FDA, and is also believed to possess a somewhat low possibility of abuse. That being said, Ambien could be habit-forming particularly in cases when it really is taken longer that the short-run treatment. Those utilizing the medicine often for than four or five weeks will want to look into other reasons to the insomnia. Addiction to this drug occur when there is often a hidden illness either physical or mental that’s affecting the patients inability to sleep. If one is dependent on this drug, they need to not try and stop by themselves without right treatment. Symptoms of Ambien withdrawal include insomnia, fatigue, stomach cramps, and panic disorders.
Prescription Drugs. Ambien, Sonata and Lunesta?? can be prescribed medications for insomnia. As most of these insomnia prescriptions will not be appropriate for individuals, who are suffering from depression or anxiety. Insomnia vitamins, for instance Kavinace, melatonin and valerian are popular alternatives. Southern California, Dr. Angelica Zaid prescribes Kavinace to patients, struggling with menopausal symptoms and work anxiety.
The patient is immediately confronted with close observation specifically for internal or external bleeding symptoms once a bladder prolapse reparative procedure. When the bladder is perforated, it might be a reason with the patient to bleed internally even with this sort of long period of time.If the person experiences drowsiness and feeling lethargic most likely, this is usually a symbol of anemia caused by a slow internal bleeding. But in massive hemorrhage through rapid internal bleeding, the affected person might end up in hypovolemic shock. For this reason, an in depth observation on the person’s urine, a higher level consciousness, and vital signs is critical.
Both are prescribed drugs which are authorized by the FDA to the treating nicotine addiction. When it comes to approval, there is certainly hardly any to select from the 2 main. The birth of Zyban has not been being a tobacco drug; it absolutely was primarily developed just as one anti-depressant. During its many studies, Zyban was noted to come up with enterprise the desire to smoke amongst smokers who took part in these trials. Over time this beneficial effect continues to be extensively recorded, but researchers are nevertheless unsure with regards to how Zyban is proven to work. The problem with Zyban is always that here are a few psychological uncomfortable side effects for this intake with this medication.
To sleep, perchance to dream, perchance to adopt…buy Ambien? This common sleeping pill has dangerous negative effects, warns Dr. Oz. Because women don’t metabolize Ambien as soon as men, they can experience what has been termed as a “Zombie” state through which they perform tasks including driving without getting fully aware about their actions.
As of not too long ago, the U.S. Food and Drug Administration (FDA) required manufacturers never to just include strong warnings inside labels but develop warning guides for distribution with nearly all hypnotic sedative sleeping medications. These Patient Medication Guides are handouts presented to patients, families and caregivers in the event the sleeping prescription medication is dispensed.
Ambien Side Effects Can Make One Think Twice Before Utilizing It
According to experts in internal medicine, complications for example a punctured bladder can come about on account of a bladder prolapse surgical procedure .Adverse events such as this one are hoped for into the future about especially because the surgeon’s field of vision is fixed; concurrently, the skill sets and techniques found in the use of medical instruments generally get a new result of the treatment. In the event that medical professionals are not able to identify this complication in a stage when it’s highly manageable, it may well proceed in the birth of other health concerns which will need advanced health care about reverse.
If you find it hard to visit to sleep or regularly arise in the center of the evening, then generic Ambien is the thing that you may need. The drug will help you sleep for 7 to 8 hours. Ambien could also be used on folks who suffer from semi-conscious coma. The drug is employed in cases of brain damage, in addition to improve brain function. Thus, when you have any one of these conditions, you can look at buying Ambien.
Both kinds of are widely-used to treat a multitude of sleeping problems and both feature unwanted effects that need considering before either medication. Both are used as muscle relaxants to calm the body and enable for relaxation. A large amount of Americans are not aware of tips on how to relax which permits them to achieve that.
If you’ve exhausted all the other ways of relieving stress and you still couldn’t obtain that sleep you are considering, then pills could definitely be the solution. With proper guidance, one must not be scared of taking sleeping pills like ambien. By having a doctor’s consultation, using these sleeping pills can be very safe and may also be just the thing should be used.
Chenoweth has confessed her Ambien issues in past interviews and is also open about taking Ambien. This isn’t news. But when the 41-year-old “GLEE” star tweeted “Goodnight. Ambien kicking in!” to her followers, her 2010 “Ambien Tweet” diaster probably crossed your brain of Perez Hilton as well as other Tweeters (Nine exactly, in accordance with RT’s adjusted publish).
The Food and Drug Administration strongly recommends the dosage amounts of zolpidem for female be lowered to five milligrams from 10 milligrams for immediate-release products as well as 6.25 milligrams from 12.5 milligrams for extended-release products. Patients who makes use of the extended-release varieties of these drugs offer an even and the higher for next morning impairment, based on the FDA.
Sleep spindles relating to the hippocampus play an important role in short-term to long-term memory in transferring memories and are also vital in emotional memory. During the course of the research it turned out discovered how the sleep spindles not REM sleep, as had been thought, get excited about emotional memories.
Social Anxiety Disorder just might be the commonest psychological disorder in the United States today. For individuals with this disorder, every social interaction seems trying – they are self-conscious, almost loathing, and extreme fear. Anxiety is actually an understatement. It is really a phobia. Parties are unthinkable for many people, family dinners can be tough, school and work impossible, as well as simple items like visiting a restaurant are actually tough.
Xanax (alprazolam) can be a prescription medicine employed to treat panic attacks and anxiety disorder. It is section of a gaggle of medications called benzodiazepines. As with other benzodiazepine medications, there is usually a probability of becoming endlaved by buying Xanax online. Addiction, or “dependence,” takes place when anyone feels as though he / she should always please take a medicine, regardless of whether no medical should get is present.Addiction to Xanax is a bit more likely if your medicine may be taken daily a bit longer or at higher doses. It is also more probable in people who have a record of alcohol or substance abuse. People taking Xanax for social anxiety disorder are often in a dangerous of addiction, since high dosages tend to be forced to control panic attacks symptoms.
Order Xanax online experinence
After a few years utilizing small dose of Xanax online once or twice every week, Ella found out that she was having a lot more uneasyness. In addition, she suddenly created a new symptom: she would awaken early with internal shaking that they found very disturbing. Medical tests invented nothing.
What Is General Anxiety Disorder
With the daily stresses of life, fairly for those to possess anxiety occasionally. Everyone has natural triggers of hysteria that will may help as in the dangerous situations etc. An example of this might be visiting a bear inside the woods. In this sort of situation fear or anxiety is triggered causing us to remove ourselves on the situation at the earliest opportunity. If we was lacking this ‘trigger’ than we’d be numb with a situation and the majority likely not react, keeping inside ourselves dangerous situations. Then, you’ll find anxiety attacks, a good example of an anxiety can be general panic disorder. General panic disorder is usually mild to severe which enable it to have serious side effects inside a persons life.
Recent studies demonstrate which the usage of benzos can in fact cause anxiety being worse in several situations. Health associations world wide propose that drugs that belong to this group, including Ativan, Klonopin, Xanax and Valium be tied to a usage lifetime of 2-4 weeks to get anxiety levels manageable, but a majority of are prescribed benzos for decades. Long term use is considered over 2-4 weeks, and will bring issues of tolerance, where a lot of the drug is needed to calm the nerve fibres, together with rebound anxiety, insomnia, weakness and cognitive decline.
Check possible Xanax addiction hazadrs
Generic Drugs are not much of a new choice of medicines; it’s been present from the introduction of the twentieth century. But, it became famous from last decade. Previously generic drugs were regarded as being the drugs with inferior quality. It was all with the work and efforts do through the generic drug manufacturer which has result in increase the position in the generic drugs worldwide. It was inside 1910 that first generic drug was introduced inside the market. It really got excellent support from the market industry and was sold much like the hot cakes. But, that it was the branded drug manufacturer that has been experiencing the loss. Thus, branded drug manufacturer filed in a situation from the generic drug manufacturer. Court gave the actual result within the favor on the branded drug manufacturer, thus the generic drug option became unavailable to those.
Whitney Houston was created during the year 1963. She was raised in Newark, New Jersey in a very middle class family, daughter of John Russell and Cissy Houston. Her lineage and family ahead of time was very linked to musical genres like gospel, pop, rhythm & blues, and soul. Later on in 1967 as soon as the Newark riots, they later gone to live in East Orange, New Jersey.
The therapeutic link between kratom are wide-ranging. In smaller amounts, there’s an invigorating effect, keeping mental performance focused and providing energy while with the same time preventing that jittery feeling that comes using stimulating plants. It will let the user to pay attention to the duty in front of you and also be a great deal less distracted, while feeling fully awake and alert. In larger amounts, it possesses a sedating and analgesic effect. This has been a lifesaver for a lot of chronic pain patients whorrrre weary of narcotic pain medications. An infusion of kratom tea for the analgesic level will last 6-8 hours, while giving the affected person a sense of well-being and calm that they’re going to not get with traditional pharmaceuticals. Many people who are suffering from chronic pain are finding kratom instead of narcotic pain medication. There may be some nausea in the event the kratom is taken when it reaches this level, but generally if you lies down, that could pass. There may also be some initial sweating and pupil dilation, yet, this can pass.
Benzodiazepines: These are drugs like Valium, Xanax and Ativan which can be generally prescribed for treatment of anxiety. The tranquilizing or sedative effect that this drug has is hypnotic naturally and it likewise relaxes the muscles. This family of drugs is addictive along with the withdrawal symptoms is very dangerous too. This is since continuous slowing with the brain can lead to a surging ahead once the drug hasn’t been consumed producing seizures and hemorrhages. An easy in your own home Xanax Drug Test can detect if Xanax or even a drug with this class of drugs continues to be consumed with 96% accuracy and also a detection amount of three days into a week after consumption.
Cocaine addiction, at 25%, ranks far behind heroin addiction, at 53%, within the prevalence of drug use from the United States. Yet, with regards to the net search frequencies of such two specific phrases, the word “cocaine addiction” is typed into engines like google more reguarily – over 115,000 times each year; in comparison to some 74,000 mission to find “heroin addiction”. Do the more predominant middle class cocaine users vs. heroin users just have more access to the Internet, as well as the first stage of help, versus the more poverty-stricken heroin users and families?
If you haven’t noticed, men and women today seem to be suffering from more illnesses and diseases than they ever have. The fact that individuals are generally unhealthy and also out of shape is one of the principal reasons for this. And the majority of these individuals tend to be overweight, as most people who are in good shape don’t get sick as often. In this article we are going to review a couple of things you can do to help yourself to get healthier and also end up losing a couple pounds in the process.
Exercise is one of the primary keys to good health but some people claim they are too busy to get any kind of exercise. Nevertheless this is really important for your over all body health. You should know, specifically people who have desk jobs, that without exercise a lot of the food you take in eventually ends up turning right into fat deposits. And that means you need to begin getting some form of exercise everyday, even if it is just taking a walk after dinner. All in all, walking is better than not doing anything.
Now we have to start taking a look at the foods your eating everyday. So many individuals end up going to the fast food places and grabbing a cheese burger for their lunch since it is the easiest thing to do. But all that food that you eat from these take out places are pretty much the worst type of food you can eat. In cases where a cheese burger is what you want, cook it yourself on a grill that allows the grease and fat to drip away from the burger so you don’t wind up eating it. If you actually want to get started on eating healthier you ought to keep reading this article.
The first thing you should be consuming everyday is at least 5 portions of fruits and vegetables. The vitamins and nutrition detected in these sorts of foods can actually make it easier to fight off certain ailments and diseases. Just eating fruit can also be an option for those people who just can not eat vegetables. Which means that you will be consuming 5 or 6 helpings of fruit everyday as an option. If of course you can choke down a few vegetables that would be much better but just eating fruit is definitely better than not eating any produce at all. Also try to eat your fruit and veggies before starting on your main course. The key goal of doing that is to begin filling you up before getting to the other foods on your plate that are not as healthy and balanced for you.
Before you have a seat to eat your dinner or any other meal, try having an entire glass of water before you begin eating because this can also cause you to feel fuller faster. The water will not only help fill you up it also helps you to purge your body of toxins. Many people end up finding that they are hungry in the mid morning, in such a circumstance have some water and also a piece of fruit, which should hold you over. And by using that little trick you’ll be less likely to hit those hamburger joints during the day.


Blow had so much fun designing The Witness that he ended up making what is potentially a 30-hour game.
Twelve games industry figures, including David Jaffe and Cliff Bleszinski, told GamesBeat which current-gen games they think deserved a wider audience.
The Witness will take more than 25 hours to beat when it launches in early 2014.
Editor’s Pick The iPhone 5S is the world’s first 64-bit smartphone. Some developers explain how that will help make games better.


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Money Matters with Wes Moss
Wes Moss, CERTIFIED FINANCIAL PLANNER™ answers questions from listeners and discusses the latest money news on this live call-in show which has been on the air since 1992. In each episode, Wes covers topics related to investing, retirement, pensions, insurance, and economics. Author of You Can Retire Sooner Than You Think, Wes is focused on helping people retire sooner and happier. For more information visit WesMoss.com.

domain: economics


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Indian school teacher found dead in Maldives
An Indian school teacher has been found dead in Maldives' Eydhafushi island, in what is suspected to be a suicide case.world Updated: May 22, 2013 13:31 IST
An Indian school teacher has been found dead in Maldives' Eydhafushi island, in what is suspected to be a suicide case.
Vice President of Baa Eydhafushi Council, Mohamed Riza said that the teacher, an Indian citizen by the name Satish Kumar was found hanging inside his room earlier on Tuesday.
Riza said Kumar's body was discovered when the school checked his residence after phone calls went unanswered, as he didn't show up for work.
"The teacher teaches computing in the island school. He was also admitted in the hospital last week after taking a bunch of medicines," Riza was quoted as saying by the Sun daily.
Riza said he went to the hospital where he received news that the teacher had been dead for eight hours.
"We do not know why he had committed suicide, there are lots of rumors spreading around but I do not wish to say those things because they might not be true," he said.
"He was a very friendly teacher and used to hang out with islanders," he said adding Kumar has been working on the island for three years and five months.
The daily reported that there are rumors going around in Eydhafushi that the alleged suicide was related to a relationship the teacher had with girl in the island.
First Published: May 22, 2013 13:27 IST


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Hand-held cell phone use ban: 16 states, dc, puerto rico, guam and the us virgin islands prohibit all drivers from using hand-held cell phones while driving all cell phone ban: no state bans all cell phone use for all drivers, but 38 states and dc ban all cell phone use by novice or teen drivers, and 21 states and dc prohibit any cell phone use for school bus drivers. The national safety council today called on state and federal lawmakers to ban the use of cell phones and text-messaging devices while driving and also urged businesses to prohibit it the nonprofit, nongovernmental group cites studies showing that the practice is as dangerous as driving drunk.
Cell phone bans for drivers: wise legislation singapore prohibit all cell phone usage while driving of the hazards of using cell phones while driving. Except for novice drivers and bus drivers, there is no prohibition on cell phone use while driving in louisiana however, all louisiana drivers are prohibited from texting. Ghsa policy click here to view ghsa's policies and priorities on distracted driving prohibit all drivers from using hand-held cell phones while driving.
Mobile or cell phone use for any purpose while driving is prohibited in the state of illinois the new state law does exempt the use of gps and other hands‐free devices. Cell phone usage policy & guide some states have passed laws prohibiting the use of handheld devices while prohibits the use of cell phones while driving. Drivers over the age of 18 with learner’s permits are prohibited from using handheld cell phones during the first six months of driving all drivers are prohibited from texting and using handheld communication devices when in school zones school bus operators are prohibited from using cell phones when driving if children are present austin was the first city in texas to enact a city-wide ban on texting while driving. Drivers with learner's permits are prohibited from using handheld cell phones in the first six months of driving drivers under the age of 18 are prohibited from using wireless communications devices school bus operators are prohibited from using cell phones while driving if children are present.
A federal safety board called tuesday for a nationwide ban on the use of cell phones and text messaging devices while driving. Restrictions on use of cell phones while driving some of the states have strict cell phone regulations for novice drivers prohibiting them from talking on a cell.
Text messaging law effective january 1 2009 cellular phone laws effective such as a cell phone, while driving a motor this law does not prohibit.
Cmv drivers are prohibited from texting while driving do not type or read a text message while driving a cmv use of mobile phones is restricted for cmv drivers. An alarming number of traffic accidents are linked to driving while approximately 660,000 drivers are using cell phones or and 20 states and dc prohibit.
Survey finds fortune 500 companies prohibiting employees from using cell phones while driving allowing employees to use cell phones while driving may mean. Cell phones, texting, and driving: state laws the use of handheld cell phones while driving enacted laws that prohibit local jurisdictions from. The national safety council called on lawmakers to ban the use of cell phones and text-messaging devices while driving.Download


Dubai-based real estate developer Deyaar Development has awarded a contract worth AED370m ($100.7m) to the primary contractor Gammon & Billimoria to deliver the third and fourth phases of Midtown community development.
UAE-based property development firm Arada has awarded a contract worth AED102m ($27.8m) to Al Marwan General Contracting Company at Aljada, the AED24bn ($6.5bn) mixed-use community project in New Sharjah, UAE.
Arada, a property development company, has unveiled a new garden villa community at Aljada in Sharjah, the capital of the United Arab Emirates (UAE).
UAE-based Arada Developments has awarded a contract worth AED423m ($115m) to Best Building Contracting Company for the construction of East Village, the second phase of Sharjah megaproject, Aljada.
Saudi Arabia’s Diriyah Gate Development Authority (DGDA) has commenced construction on SAR75bn ($20bn) Diriyah Gate, a new cultural and lifestyle tourism destination located in Diriyah, Riyadh.
Abu Dhabi-based master developer Modon Properties has awarded three contracts worth AED2.374bn ($646.2m) to deliver infrastructure works for the second and fifth phases of Riyadh City South project in the UAE.
UAE-based private developer Azizi Developments has completed the Samia, its residential and commercial development in Al Furjan, Dubai.


How much does a headlight housing cost?
If you replace the entire headlight unit yourself, the average cost might be $75 to $400. Take it to an auto repair shop, and you’ll have to pay at least $250-$1000 in headlight assembly replacement cost.2022-01-19
Can you just replace the plastic on a headlight?
The most common reasons for replacement are damage and discoloration due to oxidation. Replacing the lens on a headlight is one of the easiest auto repair tasks to do and requires nothing more than a screwdriver. The most important part of replacing a lens is to get the correct size lens for the vehicle.
What is the piece called that holds the headlight?
What Is a Headlight Mounting Panel? Often overlooked, but integral to your vehicle’s performance is the headlight mounting panel. This plastic, fiberglass or sheet metal part holds your car or truck’s headlights and grill in place.
What does a headlight assembly include?
The four main parts of your headlights include the housing, the regular beams, the high beams, and turn signal bulbs. The housing is the hard-plastic cover that you see when you are looking at a vehicle head-on. The regular beams are what is activated when you turn on your headlights or use your daytime running lights.2018-01-31
Where are headlights connected to?
Headlights of a car are connected in parallel. In parallel connection, each headlight is exposed to the full potential difference supplied by the car’s electrical system, giving maximum brightness. Another advantage is that if one headlight burns out, the other one keeps shining.2017-07-24
What does a headlight connect to?
A headlight socket is a female connector for a headlight bulb that acts as a power supply for the bulb. The headlight socket consists of a female connector designed to work with bulbs, attached to a pigtail of wiring that hooks up to the car’s electrical system.2022-04-29
What does the headlight wiring harness connect to?
The wiring harness connects to the base of the headlight bulb as well as the power distribution center in the engine compartment. No extraneous parts need to be removed to rewire the headlight, although the exact process varies by make and model of vehicle.
Whats a harness on a headlight?
A wire harness is installed so that your factory headlight circuit can control your new HID system properly. Generally speaking you can’t just plug the ballasts into the sockets that powered the halogen bulbs and expect them to work reliably or even at all.
How much does it cost to replace headlight assemblies?
$250 to $700
Where do headlights get power from?
Car headlights are powered by the car’s battery when the vehicle is off. After you start the car, the engine begins providing power for all of the car’s electrical systems, including charging the battery. The alternator carries energy from the engine to the electrical components of the vehicle.2021-08-10
What is the headlight housing called?
Reflector headlight housing The bowl-like compartment is made of a glass mirror that reflects the lights generated onto the road. The reflector headlights are also known as sealed beam headlights.
What holds a car headlight in place?
Three wires are attached to a plug located the base of the headlight itself. This plug is held in place by a plastic catch, a metal clip, or, in some cases, a screw cap. For a plastic catch, you’ll see a little lever sticking up at the top of the plug. Press down with your thumb while pulling firmly but gently.2018-07-02
Where do headlights plug in from?
Open your hood and locate the headlight near the front of the vehicle. It will be in a bulb holder, with a power connector (usually three wires) leading to the bulb. The power wires are attached to a plug at the base of the headlight, and held by a plastic catch, a metal clip or a screw cap, depending on your vehicle.
Why are headlight assemblies so expensive?
Well, the bulb alone can often exceed $100. The higher price comes from the simple fact that xenon light bulbs are much more powerful than a halogen, and while a xenon headlight is designed to last much longer than a halogen, it can still burn out eventually.


Sweden’s legendary footballer Zlatan Ibrahimovic has announced his retirement from professional football after a trophy-laden career at Europe’s few renowned club. The decision to retire at 41 comes after his side's 3-1 win over Verona in Serie A. Karim Benzema Receives Standing Ovation From Fans As He Leaves Santiago Bernabeu In His Last Match For Real Madrid (Watch Video).
Zlatan Ibrahimovic Retires
"The time has arrived to say goodbye".
We will miss you, forever and 𝐀𝐋𝐖𝐀𝐈𝐙❤🖤
Good luck in retirement 👏 pic.twitter.com/vF0w3kCKU9
— Lega Serie A (@SerieA_EN) June 4, 2023
Zlatan Ibrahimovic Announces Retirement
🚨 BREAKING: Zlatan Ibrahimović has now decided to retire from professional football with immediate effect.
Incredible player, incredible icon. 🦁👋🏻 pic.twitter.com/UwtqwsyUcZ
— Fabrizio Romano (@FabrizioRomano) June 4, 2023
(SocialLY brings you all the latest breaking news, viral trends and information from social media world, including Twitter, Instagram and Youtube. The above post is embeded directly from the user's social media account and LatestLY Staff may not have modified or edited the content body. The views and facts appearing in the social media post do not reflect the opinions of LatestLY, also LatestLY does not assume any responsibility or liability for the same.)


Fri, 01 Dec 2017
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The 31-track set, due out in February, features music from Octo Octa, Golden Teacher and the late Johnny Igaz, AKA Nackt.
Mon, 30 Jan 2017
The label will repress cassettes from artists who died in last year's Oakland warehouse fire, with proceeds going to their families.
Thu, 17 Nov 2016
Keita Sano, Sage Caswell and Inoue Shirabe feature on the 11-track cassette.
Wed, 04 Nov 2015
Daniel Lanois and Gifted & Blessed are also part of this Friday’s event.
Wed, 29 Jul 2015
The Los Angeles label will put out cassettes by Paradise 100, Cherushii and Auscultation in August.
Mon, 22 Sep 2014
Brian DeGraw, Gabe Gurnsey and Maria Minerva have also been tapped up to rework the Houndstooth act.
Tue, 26 Aug 2014
Holly Herndon, Maria Minerva and Paula Temple are among the last additions to the Dutch festival's bill.
Mon, 31 Mar 2014
The Estonian artist will release her next album through Not Not Fun in April.


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Flights to Leh for our Ladakh trip later this year are finally booked! Markha Valley and Gompas galore, here I come.
My attempt to buy got flagged as fraud by my bank (by my January flurry of business trips and Nepal flight buying from the sounds of it) and when I called up to sort it out, the first person I spoke to was another Mary, and then I get put through to the person in the fraud team… who was also a Mary.
I hardly ever meet/speak to another Mary so three in one go, that’s very weird. I’m going to take it as a good sign.]
So… what, where, when, why, who?
Destination: Ladakh, India – the “land of high passes”.
How: On a private trek in Val Pitkethly‘s capable hands, with the equally capable Yangdu and the team at Rimo Expeditions helping out on the local logistics and additional tours in Leh and Delhi. Flights booked with Air India.
When: September – after the peak summer season but before the snow.
- Day 1 – Flight to Delhi
- Day 2 – Land Delhi, very early morning flight to Leh
- Day 3 – Leh – Leh Palace, Old Town and Markets
- Day 4 – Leh – Thikse Monastery
- Day 5 – Leh – Spituk Monastery & Shey Monastery
- Day 6 – Leh – Festival (movable)
- Day 7 – Leh – Khardung La (5,359 m / 17,582 ft) – “the world’s highest motorable pass”
- Day 8 – Markha Valley Trek day 1
- Day 9 – Markha Valley Trek day 2
- Day 10 – Markha Valley Trek day 3
- Day 11 – Markha Valley Trek day 4
- Day 12 – Markha Valley Trek day 5
- Day 13 – Markha Valley Trek day 6
- Day 14 – Markha Valley Trek day 7
- Day 15 – Markha Valley Trek day 8
- Day 16 – Leh – Alchi Gompa
- Day 17 – Leh – Shopping
- Day 18 – Leh – Spare
- Day 19 – Flight Leh – Delhi, with 13h layover providing sightseeing potential in Delhi itself (rather than just the airport…)
- Day 20 – Flight Delhi – UK


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Pettinice with added CMC
(Plus anything you might find around the house to support outer petals)
Make cone shapes, the size depends on how big you want your rose and how much icing you have to use.
Make a wee ball of icing and push it out between a sheet of plastic. Make it slightly Longer than your cone.
Make it slightly Longer than your cone
Wrap the petals around the cone using sugar glue to adhere it. Make sure the first petal is wrapped nicely around to form the center.
Wrap the petals around the cone using sugar glue to adhere it. Make sure the first petal is wrapped nicely around to form the center Once you get to the fourth or fifth petal bend it out a little.
Next pop your next petals on to some spoons. Make these slightly larger. And remember you can use cutters! You don’t have to use a plastic bag
And remember you can use cutters! You don’t have to use a plastic bag
Remember the bigger you make the rose the larger the next set of petals need to be
Add these with sugar glue. You will need to use something to support these petals. Here I am using some tupperware a wee bottle and some food colouring containers anything will do! Lol
You can stop here or before depending on how big you want your rose!
Or make some more Petals! Make some more slightly larger , (again) petals and place on your spoons or for Really big roses you can use an apple box inner!
Attach these using sugar glue and again support and shape your petals
Walla finished! Make them with fewer petals for buds and increase for a lovely large open rose!
(Leave to dry fully supported! Other wise your petals will droop or crack and fracture!)
And Most Of All Have Fun!

domain: artistic


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Pakistan and Malaysia sign trade agreement
29 May 2007
Malaysia will allow import of Pakistan’s textile products free of duty under a new free trade agreement.
The agreeement which will come into effect on Jan 1 will be the Pakistan’s third bilateral trade arrangement after similar accords with Sri Lanka and China.
As a reciprocal agreement, Pakistan will allow import of Malaysian palm oil at preferential duty.
The treaty is estimated to enhance volume of trade between Pakistan and Malaysia to at least $5 billion in the next five years from the current figure of less than a billion dollars.


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The video revolution of the 1970s offered unprecedented access to the moving image for artists and performers. This Is Not a Dream explores the legacies of this revolution and its continued impact on contemporary art and performance. Charting a path across four decades of avant-garde experiment and radical escapism, This Is Not a Dream traces the influences of Andy Warhol, John Waters and Jack Smith to the perverted frontiers of YouTube and Chatroulette, taking in subverted talk shows and soap operas, streetwalker fashions and glittery magic penises along the way.
The tender, heartbreaking story of a young man’s struggle to find himself, told across three defining chapters in his life as he experiences the ecstasy, pain, and beauty of falling in love, while grappling with his own sexuality.
Flamboyantly gay Austrian television reporter Bruno stirs up trouble with unsuspecting guests and large crowds through brutally frank interviews and painfully hilarious public displays of homosexuality.
Four tales unfold in the Eternal City: While vacationing in Rome, architect John encounters a young man whose romantic woes remind him of a painful incident from his own youth; retired opera director Jerry discovers a mortician with an amazing voice, and he seizes the opportunity to rejuvenate his own flagging career; a young couple have separate romantic interludes; a spotlight shines on an ordinary man.
Mr. Church reunites the Expendables for what should be an easy paycheck, but when one of their men is murdered on the job, their quest for revenge puts them deep in enemy territory and up against an unexpected threat.


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Only 2 left. Shop now!
Slip on these adorable cat pajamas and you'll be all set for a great cat nap! Made from a super soft fabric that keeps you comfy and cozy, these cat PJs feature cute cat faces that will brighten up your day the minute you put them on. They come equipped with an elastic waistband, drawstring closure and loose fit for extra comfort. The side pockets are purr-fect for keeping your hands free and ready to pet a snuggly cat!
The stretchy thick fabric and cute cat themed design make these black cat pajamas suitable not only for naps and lazy days at home, but also for running errands on the weekend and laid-back brunches! Just pair them with your favorite tee and a pair of comfy shoes and you'll enjoy your time off the cat lover's way - in style and comfort!
Looking for a cute yet practical gift for a cat lover? These will be (literary) the cat's pajamas! Just add gift wrap and you'll have the purr-fect cat themed gift!
Available in sizes S-XL. Ship in 24 hours. Arrive in 4 business days.
Run true to size, so order your regular size.
Material: 92% Polyester, 8% Spandex
Pants Length: Long
Love these black cat pajamas? Click here to see more cat themed apparel!


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Moonlight Adventure Botswana 14-18 JULY 2022
PLEASE CHECK NATIONAL AND INTERNATIONAL TRAVEL COVID REQUIREMENTS:
• Facilitated by SADAC Travel and Adventure Riders SA, this is NOT a guided tour.
• This is a perfect opportunity to improve your riding skills and strengthen your network with like-minded people.
• The Expedition will start & finish at the Okes Coffee Shop in Modderfontein JHB GPS S26 05.699’ E28 09.577’
• The adventure is based around the Muddy Face Moonlight event hosted by Ross Branch & Lola Berri on the Southern Makgadikgadi Pans – Botswana Lola +26771216904
• The adventure will be open to all makes of Dual-purpose road-worthy motorbikes and 4×4 vehicles.
• All meals at the Muddy Face Event are for your own account (Budget R600.00pp) Dinner and breakfast at both Buffalo Thorn and the Kwadiwa Ranch is included in the travel package.
ONE ENTRY FORM PER PARTICIPANT (DEPOSIT PAYMENT OF R2500 MUST BE MADE WITHIN 5 DAYS OF REGISTRATION TO SECURE YOUR SPOT- BALANCE TO BE MADE IN FULL BY THE 16th JUNE 2022) If you register & pay between the 23rd April & 15th June and we are unable to go due to another lock-down or Border crossing is restricted you will receive a full refund.
No refunds will be paid if you wish to cancel after the 15th of June 2022.
ENTRIES CLOSE 25th JUNE
End of Service’
OKES COFFEE SHOP – MODDERFONTEIN
A detailed Itinerary will be provided on registration / prior to departure.
Space is limited:
Travel/Tracks & Safety
• Each vehicle/Motorbike must have a ZA sticker.
• The routes will be pillion friendly for those with experience and due to time constraints, we will need to travel on some tar and district gravel /sandy roads so please ensure that your skill levels are up to the challenge.
• We will have green and red route options.
• The Green/Orange route will mainly stick to tar roads as much as possible however you will need to travel on a short dirt section at some point. The Orange/Red route will be mostly planned to be on a district gravel road with a few single-track or goat sections in between. Please keep in mind that due to the location and nature of the terrain you could encounter some short shallow sandy sections on the gravel roads. You are guaranteed to have lots of fun on the pans at this time of the year.
• All the tracks will be available in a GPX format to be downloaded onto your Garmin device and navigated at your leisure or you are welcome to join the convoy of 4×4 vehicles led by our tour guide who will be stopping off at many interesting siting en-route to your next destination.
• Same will apply to the adventure bikes regarding the GPS tracks.
• Families, spouses/and partners are encouraged to join the expedition as either a pillion or as a passenger in a 4×4.
• There will be Adventure guides assisting and facilitating the ride between camps.
• We will have 3 first aid level 2 guides on the ride that will be able to assist in case of any mishaps along the way.
• Total distance to travel will be Est 2000km
• You can trailer to The Okes Coffee shop and park your vehicle/trailer there at no charge in a secure environment whilst we are away.
• We will have vehicles/trailers available to assist in the transport of your pillion luggage, tent, lightweight groundsheet, mattress, stretcher, chairs, and sleeping bag, you will need to carry your own luggage – clothing on your bike.
• Please inform the guides of any medical conditions you might have.
• All items should be packed in a weather/dustproof covering, NO black dustbin bags, please.
Paperwork / Documents
• No Visa is required for SA citizens
• Valid passport is required to cross into Botswana, check EXP DATE.
• A certified copy of your Vehicle/Bike and trailer papers can be requested at the border
• If the vehicle/Bike is currently financed, then you will require a letter from the finance house granting permission to cross into Botswana.
• One would need to notify your insurance & medical aid company that you will be leaving SA and traveling to Botswana
Camping & Site Set up
• Clean temporary Toilets and showers facilities will be erected by the Muddy Face event team. Bring your own towel and toiletries for all camping
• As it is winter there will be very few mosquitoes, but it is advisable to pack some sort of repellants.
• We will erect gazebos for the two-day setup on the pans.
• Firewood will be supplied for the bonfires and meals
• We suggest you buddy up to erect/dismantle your camping rig so try and keep it light and simple.
• Lightweight 2x man tents are recommended as space will be limited (NO BIGGER)
Currency & Financial
• Fuel, tolls, and border crossing taxes will be for your own account. Road tax est R220 per vehicle, R200 per trailer & R180 per Motorbike.
• NO lunches are included, NO food will be provided for whilst on the pans, and there will be food vendors at the event.
• Money can be exchanged at the bureau exchange the moment we cross the border at Martins drift.
• Current fuel price per lt P13.68 = R17.80 this could vary
• A R1235 fee per Bike/Vehicle is included in the package if you are a rider or driver, this will also cover your activities & camping on the pans, proceeds go towards Elephants for Africa https://www.elephantsforafrica.org/
• Current exchange rate is 1.30 Pula to the Rand (23/04/2022)
• Botswana does not allow you to ride a motorbike on their roads with a learner’s license from SA
• You may NOT carry Pillion at any time with a learner’s license.
• Out on the pans during the day temperatures in July can rise to 28 deg midday and drop overnight to 5 deg so pack accordingly.
• It is advisable to pack some snacks for during the day.
• Hydration pack is recommended whilst out on the bike.
• Bring along sun protection and required medication.
• The support vehicle will carry 2x coolers boxes (ice supplied) and 2x 20lt of drinking water containers.
• All items are to be clearly marked or labels attached.
• Luggage size will be gauged on what you would normally carry on your bike so no more than 40lt in volume p/p.
• You will receive a welcome response with banking details once we have received your online registration.
• Appropriate riding gear including protective boots will be compulsory for both rider and pillion, some riders prefer wearing an adventure jacket & pants, and others opt for their cooler endure gear.
• Days will be warm and nights very cool so pack accordingly
Tools/Spares and Support:
• You will need to bring along your own bike tools, spare tubes, or puncture repair kits including a compact compressor for your convenience.
• The support vehicle will carry a larger portable vehicle compressor.
• We will carry a spare front and rear Tyre for the more popular sizes, you are welcome to bring along your own to throw onto the support truck.
• Your bike must be prepped, checked, and maintained for this adventure.
• The expedition budget is based on self-camping on the pans and safari-style lodging for the first and last nights.
• No Deposit or payment paid will be refundable if you wish to cancel after the 15th of June 2022 (Please lsee further T&C on the registration form)
End of Service’

domain: travel


fix articles 122453, north waziristan
Drones: Instruments of State Terror (tags)
US brands Haqqani network as terrorist organization (tags)
Months long heated debate on notorious Haqqani network has almost come to an end with announcement by Secretary of State Hillary Rodham ClintonHillary Rodham Clinton as she said in a statement on Friday that Haqqani network – that is allegedly based in Pakistan – has been branded as a foreign terrorist outfit.
Remote Control Killing Like Sport (tags)
The War On Terror (tags)
"Pakistan warned Washington against future attacks. However, US military officials, under pressure from Obama to show progress in the endless Afghan war, responded to Pakistan’s warning by calling for expanding the Afghan war into Pakistan. On October 5 the Canadian journalist Eric Margolis wrote that “the US edges closer to invading Pakistan.” In his book, Obama’s Wars, Bob Woodward reports that America’s puppet president of Pakistan, Asif Ali Zardari, believes that terrorist bombing attacks inside Pakistan for which the Taliban are blamed are in fact CIA operations designed to destabilize Pakistan and allow Washington to seize Pakistan’s nuclear weapons."
Justice Dept. Assinations and Drone Attacks (tags)
"Between our area and Waziristan is an 8 hour journey. The drone attack happened at night time and we all knew about it by the following morning. People who had witnessed the attack had come to tell us and described what they saw of the remnants and damage in the aftermath. They said the attack was so severe that they could not even distinguish the bodies from one another- even the bones of the people were completely blown apart. The dead were completely unrecognisable. My brother in law’s coffin was tightly sealed and we were not allowed to open it to view anything. We had the coffin with us for 30 minutes before it was taken away for burial." "In fact the papers filed by the Justice Department attempting to quash the case argue that the court system should have absolutely no oversight over the administration’s sudden, bizarre claim that it can assassinate any American citizen it wants on the basis of national security, arguing that such issues are “for the executive branch of the government to decide rather than the courts.”
US-Committed Atrocities in Afghanistan (tags)
Afghan atrocities greater than ever
NYCLAW ANTIWAR DIGEST -- 12.15.08 (tags)
Political Ammunition You Can Use
Al Qaeda and Taliban takeout Islamabad Marriott (tags)
The Islamabad Marriott was believed a relatively safe haven and a favorite place for locals and foreigners to stay and socialize, despite repeated militant attacks. In January 2007, a security guard blocked a suicide bomber who triggered a blast just outside the Marriott, killing the guard and wounding seven other people.
U.S. Secret Air War Pulverizes Afghanistan and Iraq (tags)
News from the 4th Reich military forces: According to Associated Press, there has been a five-fold increase in the number of bombs dropped on Iraq during the first six months of 2007 over the same period in 2006. More than 30 tons of those have been cluster weapons, which take an especially heavy toll on civilians. Balad, which currently conducts 10,000 air operations a week, is strengthening runways to handle the increase in air activity.
Rumsfeld Helped Al Qaeda Establish a Stronghold in Northwestern Pakistan (tags)
"Why? Did the Bush administration need to "recruit detainees" among the civilian population and pass them off as "terrorists" with a view to bearing out its resolve and commitment to the "global war on terrorism" (GWOT). Did they need to boost up the numbers "to fill the gap" resulting from the several thousand Al Qaeda fighters, who had been secretly evacuated, on the orders of Donald Rumsfeld and flown to safety? In other words, are these detentions part of the Pentagon's propaganda campaign?"


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Wednesday's news summary, July 30, 2014
At least one worker at a Hudson Valley Veterans Affairs facility was "coached" during an interview by auditors conducting a nationwide assessment of VA scheduling practices, according to internal documents obtained by USA Today and reviewed by the Poughkeepsie Journal. A local VA spokesman Wednesday said the incident, at an Orange County clinic, was the result of an innocent exchange and taken out of context. The VA documents, part of a briefing provided to Congress last week, indicate auditors of the Hudson Valley Health Care System "became aware during their audit interview that another person was in the interview coaching the interviewee about their responses. The comment was listed under a section headlined "Audit Results: Overall Concerns." No other details were included in the briefing document, which summarized findings from interviews of nearly 3,800 staff at 731 sites between May 12 and June 3.
The state Education Department has produced a last-minute, preliminary "parents' bill of rights" on the use and security of student data – hours before a legally imposed deadline to do so. Ken Wagner, deputy education commissioner, sent an email to superintendents and other education officials on Tuesday evening alerting them that a bill of rights had been posted online. The Journal News reported last week that the department was unlikely to meet its July 29 deadline, set by lawmakers in the state budget. The report also said that school districts were concerned that they might be forced to write their own bills of rights to comply with state law. Wagner's email on Tuesday seemed to affirm that districts were right. He noted that state law now requires school districts to post a parents' bill of rights on their websites and to include it with every contract that a district signs enters into with a vendor that receives student data. "We are complying with the law," Education Department spokesman Tom Dunn said Wednesday.
Two Wappingers Falls men face prison for smuggling drugs from New York City to the village to sell, the state Attorney General's Office said. Michael Novick, 49, and Richard Bernal, 47, pleaded guilty to felony drug charges Tuesday before Dutchess County Judge Peter M. Forman. The men were arrested May 28 after an Attorney General's Office investigation into a drug ring that brought cocaine to Dutchess County and funneled proceeds to the Dominican Republic, the office said. "My office is committed to keeping New Yorkers safe by being both tough and smart on crime," Attorney General Eric T. Schneiderman said. "... And today (Tuesday), two of the individuals who endangered New Yorkers by polluting our communities with dangerous and illegal drugs are facing prison time for their crimes." The drug ring was led by a New York City couple, authorities allege. Eight people were indicted in the takedown known as "Operation Snowfall."
SPORTS: The Hudson Valley Renegades bring a three-game winning streak into tonight's opener of a three-game series at Jamestown. The Renegades enter tonight's game with a 32-13 record, nine games ahead of second-place Brooklyn in the McNamara Division of the New York-Penn League.
COMING THURSDAY: Food trucks. They're fun, they're funky and they're making headway in the Hudson Valley. As a culinary art, food trucks have come into their own. No longer limited to hot dogs and ice cream (though both remain perennial favorites), food trucks in the mid-Hudson Valley serve an eclectic and wide range of dishes from Asian noodles, vegetarian barbecue and flatbread pizza, to comfort food like macaroni — deep-fried in an egg roll, to an on-the-go society. Pick up Thursday's Poughkeepsie Journal for more on this.
Players previews the Millbrook Horse Trials which begins its four-day run on Thursday with some of the world's top riders and horses competing in the 14th annual event. For the first time, there's $25,000 in prize money being given to the top finishers.
Thursday's editorial says sheer demographics tell us the "graying of America" is bringing about massive societal changes, including to our country's health care system and asks the question, "Are we truly prepared?" From a regional perspective, this and many other questions were tackled by the nonprofit group Hudson Valley Pattern for Progress in a provocative report called the "Aging in the Hudson Valley" that deserves much attention.
WEATHER: Partly cloudy skies and a low of about 56 are expected tonight, according to the National Weather Service. Scattered showers and thunderstorms are in store for Thursday after 10 a.m., some possibly with small hail and gusty winds. The high will be around 80.
To read the complete versions of these stories, click "Top Stories" in the home tab of our iPhone or Android app or the Journal's mobile site, m.poughkeepsiejournal.com. You can also visit: www.PoughkeepsieJournal.com.


British Prime Minister Johnson's new coronary pneumonia condition update
Q2 Variety shows, from "Young You 2 " to "Sister", a "group" dominates
Sailor Moon repainted, can Shui Bingyue grow like this?
Five new highlights of the 2024 Paris Olympic Games emblem competition time and place are exposed
Men's Ice Hockey U20 World Championships Division B Group B finale Chinese team won the bronze medal
Israel will provide third dose of new crown vaccination for people with low immunity
Global Connection｜When science fiction shines into reality: a small translator connects the big world
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The hypothalamic paraventricular nucleus (PVN) is critically involved in elevated sympathetic output and the development of hypertension. However, changes in group I metabotropic glutamate receptors (mGluR1 and mGluR5) and their relevance to the hyperactivity of
PVN presympathetic neurons in hypertension remain unclear. Here, wefoundthat selectively blocking mGluR5 significantly reducedthe
basal firing activity of spinally projecting PVN neurons in spontaneously hypertensive rats (SHRs), but not in normotensive WistarKyoto (WKY) rats. However, blocking mGluR1 had no effect onthe firing activity of PVN neurons in either group. The mRNA and protein
levels of mGluR5 in the PVN and rostral ventrolateral medulla were significantly higher in SHRs than in WKY rats. The group I mGluR
selective agonist (S)-3,5-dihydroxyphenylglycine (DHPG) similarly increased the firing activity of PVN neurons in WKY rats and SHRs.
In addition, blocking NMDA receptors (NMDARs)through bath application or intracellular dialysis not only decreasedthe basal firing in
SHRs, but also eliminated DHPG-induced excitation of spinally projecting PVN neurons. DHPG significantly increased the amplitude of
NMDAR currents without changing their decay kinetics. Interestingly, DHPG still increased the amplitude of NMDAR currents and
caused reappearance of functional NMDAR channels after initially blocking NMDARs. In addition, protein kinase C (PKC) inhibition or
intracellular dialysis with synaptosomal-associated protein of 25 kDa (SNAP-25)-blocking peptide abolished DHPG-induced increases in
NMDAR currents of PVN neurons in SHRs. Our findings suggest that mGluR5 in the PVN is upregulated in hypertension and contributes
to the hyperactivity of PVN presympathetic neurons through PKC- and SNAP-25-mediated surface expression of NMDARs.


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