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In a hastily-thrown-together funding package passed just before Christmas, Congress agreed to fund the Children’s Health Insurance Program for six months, backdated to September when they allowed the program covering roughly 9 million children and pregnant women to expire. That nearly $3 billion emergency stopgap was supposed to carry CHIP until the end of March, but states are reporting that they could run out of money in just a few weeks.
The Trump administration’s Centers for Medicare and Medicaid Services now says it can only guarantee full funding for all states through late January, sparking uncertainty for millions of low-income families across the country.
“We appreciate that Congress included funding for CHIP in the continuing resolution that runs through January 19, 2018,” CMS spokesperson Johnathan Monroe said in a statement to TPM. “The funding included in the CR should carry all the states through January 19th based upon best estimates of state expenditures to date.”
CMS is “unable to say with certainty” whether the stopgap funding passed by Congress will allow every state to continue its CHIP program through March 31. The agency is currently in talks with the hardest hit states, though exactly when funding will run out for whom is a “moving target.” Certain factors, including the hurricanes and floods that have hammered Texas, Florida and other states, have drained the funding reserves faster than expected.
Already, some states have begun to send out notices to families warning them that their children’s insurance may no longer be available in the coming months.
While Congress ultimately passed a six-month stopgap for CHIP and a handful of other health programs in frantic budget negotiations in late December, the original plan was to pass a full five-year reauthorization of the program. Republicans and Democrats in the House and Senate came together in a rare moment of agreement on the substance of the CHIP bill, disagreeing only on how to pay for it. Republicans have demanded that CHIP be funded by making deep cuts to the Affordable Care Act’s prevention and public health fund, a choice Democrats strongly oppose.
Those arguments may now be much easier to solve.
On Friday, the Congressional Budget Office released a revised estimate of the cost of funding CHIP for five years, dropping the bill down from more than $8 billion to less than $1 billion. The CBO says that Republicans’ move to kill Obamacare’s individual mandate is likely to significantly raise premiums in Obamacare’s individual market—which is where many children and parents are likely to turn if CHIP disappears—costing the government a lot more in subsidies. Thus, by running up the cost of failing to fund CHIP, Congress has made it comparatively much cheaper to renew the program.
Senate Majority Leader Mitch McConnell (R-KY), in a floor speech last week, called on his colleagues to get it done.
“Partisan objections forced Congress to settle for a short-term patch,” he said. “This month, we can set this right. I know that colleagues on both sides of the aisle are eager to find a long-term solution. Five years, full reauthorization. Let’s get this done for working families.”

domain: politics


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I wore goofy hats to school and did musical theater. Most people thought I was a dork. But if you have a sense of humor about it, no one can bring you down.
If you'd have asked me when I was auditioning for High School Musical if I ever thought I was going to play a Marine.
I can tell that fame is probably the most unadorable thing about acting. High School Musical is what got me here today and I'm very grateful - but the fame part isn't so fun.
I want to grow up, live my life, experience things, make movies about those experiences and by the time the audience catches up, hopefully they'll have a movie there that helps them get through that next phase when they discover life isn't always like High School Musical.
We shot 'High School Musical' in eight weeks. I spent longer rehearsing for 'Hairspray' than filming 'High School Musical'.
High School Musical has been a blessing and a gift.
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domain: artistic


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George Unleashed is a popular animated show that has captured the hearts of kids and adults alike. With its vibrant characters and engaging storylines, it has become a household favorite. And now, fans can dive deeper into the world of George Unleashed with the official merchandise line.
The merchandise line features a variety of products, from apparel to accessories, all showcasing the lovable characters from the show. Fans can now bring their favorite characters to life and add a touch of George Unleashed to their everyday lives.
One key aspect that sets this merchandise line apart is its high-quality design and attention to detail. Each product is carefully crafted with vibrant colors and intricate designs that truly capture the essence of George Official Merch Unleashed. From t-shirts featuring bold graphics to plush toys with soft fur, every item in this collection is sure to bring joy to fans young and old.
But the appeal of this merchandise line goes beyond just aesthetics. The products are also made with durability in mind, ensuring that they will last for years to come. This makes them not only great collectibles but also practical items for everyday use.
For those looking for clothing options, there are plenty of stylish choices available in various sizes for both kids and adults. From casual tees adorned with catchy slogans to cozy hoodies featuring iconic scenes from the show, there’s something for everyone in this clothing range.
The accessory collection includes items such as bags, hats, phone cases, and even drinkware – all perfect for adding a touch of George Unleashed flair wherever you go. These accessories are not only functional but also serve as great conversation starters among fellow fans.
Perhaps one of the most exciting aspects of this merchandise line is its potential as gifts for loved ones or fellow George Unleashed enthusiasts. These products make memorable presents that will bring smiles not just because they are licensed merch but because they represent something personal between friends or family who share love for the show.
But it’s not just about consumption – this merchandise line also allows fans to contribute to a greater cause. A portion of each purchase goes towards organizations that support animal shelters and conservation efforts, further reinforcing the show’s message of love and care for animals.
No longer do fans have to scour the internet for unofficial or knock-off George Unleashed merchandise. With the official line, they can be assured of quality products that directly support and represent their beloved show. So whether you’re a long-time fan or new to the world of George Unleashed, now is the perfect time to discover and unleash your love for this beloved animated series with its official merchandise line.

domain: hobby


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The sixth Lewes Chamber Music Festival will place take over the weekend of 23rd – 25th June. Set across three days the festival brings together internationally renowned musicians for eight concerts in the intimate setting of the All Saints Centre, along with one late-night-concert held at St Michael’s church on the opening night.
Exploring the romantic world surrounding Robert Schumann the programme includes music by Chopin, Schubert, Mozart and Beethoven as well as lesser-known German composers, Hermann Goetz, and Robert Kahn. The Festival is also privileged to this year be welcoming composer and pianist Huw Watkins, to perform and present a number of his chamber music works.
There is a stellar line up of musicians: pianists Sam Haywood and Tom Poster along with composer Huw Watkins and a special appearance on Saturday night by tenor James Gilchrist. Joining them are musicians who have appeared at the Festival in previous years: star clarinetist Matthew Hunt, viola player James Boyd, Swedish pianist Bengt Forsberg and award-winning Scottish cellists Philip Higham and Robin Michael. New to Lewes are the fantastic horn player Alec Frank-Gemmill who will be playing the natural horn, and Serbian violinist Bogdan Božović. Among the younger of the performers are brilliant violinists Mathilde Milwidsky and Tim Crawford, both still studying at London music colleges.
The Festival makes it home in the intimate and atmospheric setting of the All Saints Centre in the middle of Lewes. Renowned piano-maker Paul McNulty will be bringing three beautiful replica period pianos from his workshop in Prague especially for the Festival. These pianos will showcase a sound-world that would have been familiar to the composers writing through the ages. There will be an opportunity to discover all about these instruments in a talk on the Saturday afternoon and the Festival’s internationally renowned pianists will be showing these instruments off throughout the weekend.
The concerts offer a rare opportunity to listen to music performed at a level not often heard outside the big cities, and in an intimate ‘festival’ atmosphere. This makes it an unmissable weekend of concerts for all music-lovers. To enable younger people to attend, tickets are completely free of charge for those under 26 years old.
Tickets on sale from 1st April from £12- £16 from the box office on 01273 47865 or from Baldwins Travel Agency in Lewes. Tickets may also be bought online from our website. Full information at www.leweschambermusicfestival.com


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Finally, a budgeting app for couples with shared finances.Honeyfi is a savings and budgeting app that caters to couples. It offers a centralized platform for you and your partner to track your spending, view upcoming bills and hit your savings goals together.
But it’ll cost you to use it. Expect to pay $60 a year, which is equivalent to $5 a month.
$60 per year
Minimum deposit to open
Kimberly Ellis is a writer at Finder. She hails from New York City with a BA from Queens College and a New York State teaching certificate. After teaching in both public and private schools, Kimberly decided to take the world by storm and dive into the media industry — where she covers everything from home loans and investing to K–12 education and shopping. She’s also an aspiring polyglot, always in a book and forever on the hunt for the perfect classic red lipstick.
Expert reviewHoneyfi is best for couples who want to start budgeting and managing their finances together. Adjust your budgets and even make specific transactions private, to prevent your partner from seeing any surprise purchases you’re making for their birthday, anniversary, or other occasions.
Through its savings goals program, you’ll also earn 0.5% APY. But the interest will only get paid out to you every three months. If savings is what you’re after, you’ll want to consider opening a seperate savings account.
Also, before signing up, make sure your bank or credit union is available through Paid as some smaller financial institutions can’t be linked to your Honeyfi account.
How much does Honeyfi cost?Honeyfi has a free trial for 30 days and then costs $60 per year — equivalent to $5 per month — for both you and your partner. There’s no fee to use its Goals program and you won’t pay a fee for withdrawing your money.
How to sign up with Honeyfi:
Get started in five steps:
- Go to the provider’s site and follow the steps to apply.
- From the provider website, select Get started.
- Add your contact information, including your name, email address, cell phone number and password.
- Link your bank accounts by providing the login information to your financial institution.
- Honey downloads your transactions and recommends a household budget based on your current spending habits.
- Review your budget and customize it for your situation.
If you want to set a savings goal, you’ll need to link a checking account. You can fund your Goals account with one-time deposits or set up automatic transfers.
What are the pros and cons of Honeyfi?
Here are a few Honeyfi advantages and limitations.
- Can automate savings. Automatically transfer money out of your spending account, make saving a habit and increase your chances of reaching your savings goals.
- Collaborate with your partner. Unlike other budgeting apps like Mint, Honeyfi is designed for couples to team up and manage their finances together.
- Customizable. Honeyfi lets you tweak your budgets and can even make specific transactions or accounts private to prevent what your partner can see.
- Subscription. Honeyfi isn’t free to use. You’ll pay $60 a year for both you and your partner.
- Couples-only. This budget app is not designed for single users. It also requires a certain level of trust between you and your partner to share financial information.
- Low interest rate. Although Honeyfi‘s Goals program earns interest, you’ll only get 0.5% APY that gets paid to you every three months. You can earn more with a high-yield savings account.
- Doesn’t link to smaller banks. Honeyfi lets you link your accounts from over 10,000 financial institutions across the US. But there are a few complaints about Honeyfi’s inability to link to smaller banks and credit unions that aren’t available to Plaid.
Is Honeyfi safe to use?
Yes. Honeyfi uses Plaid, a financial services company, to securely connect your bank to the app. Plus, it’s savings goals program helps users save by storing their funds in an FDIC-insured bank account.
Compare Honeyfi to other budgeting apps
Compare Honeyfi with other savings apps by monthly fee and platform.
We update our data regularly, but information can change between updates. Confirm details with the provider you're interested in before making a decision.
Frequently asked questions
What happens if I have an automated transfer to my Goals account, but I don’t have enough in my checking account?Honeyfi makes sure that you have enough funds to cover the transfer and at least $150 remaining before initiating a transfer to your Goals account.

domain: economics


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26/11/2018 Tour Packages, Vacation Deals
Parth Tours India is one such travel agency that provides budget-friendly domestic and international family holiday packages in India, It includes the LTC tours as well. Some of the other services the company provides are Visa assistance, Insurance, Hotel and Flight booking and so on. Choose the best Travel Agency, Parth Tours India Pvt Ltd.
Web :- https://www.booktoursonline.com/
Get amazing deal on exclusive International Tour Holiday Packages in India for for family, group friend’s vacations and more in Dwarka, Janakpuri, Del...
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domain: travel


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Indiana has joined a parade of states suing Standard & Poor’s over its awarding of favorable ratings to securities that blew up when the housing market collapsed.
Indiana’s case, filed Thursday in Marion Superior Court, charges S&P with “systematically and intentionally” misrepresenting its analysis of securities backed by commercial or residential mortgages in order to “maximize revenue and market share.”
At least 17 states have filed similar lawsuits. Indiana’s case, filed by Securities Commissioner Chris Naylor, does not specify the amount of damages the state is seeking. It alleges fraud, deception and violations of the Indiana Uniform Securities Act.
S&P, a unit of New York-based McGraw-Hill Cos., has denied wrongdoing and said that any lawsuit would be without merit.
The state says investors relied on S&P to accurately rate the riskiness of various mortgage-backed securities.
Issuers paid the firm and its chief rival, Moody's Investors Service, substantial amounts to assess the investments, which grew ever-more complex through the 2000s. The state charges that S&P's desire to win additional business colored its analysis.


Ruth Cadbury MP today questioned Transport Secretary Chris Grayling over his determination to pursue expansion at Heathrow without it being conditional on additional rail access to the airport from the South and West.
Speaking after the debate Ruth said ''The Terminal five Inquiry Inspector recommended in 2001 that significant additional rail capacity was needed for that expansion, and without it we've seen traffic congestion and pollution get ever worse across West London and far beyond. The department for Transports own figures say that Runway 3 means an additional 54,800 vehicles on the road per day, which will in turn only make our congestion and air pollution problems much worse. So it's baffling that the government aren't addressing this by ensuring there's a condition on expansion that requires southern and western rail access to Heathrow be in place before the third runway can open. With Heathrow announcing this week that they want to add an extra 25,000 flights soon and then a third runway, it's clear that the government need to act to address the impact that transport congestion has on the local economy, on our health and of course on Heathrow's ability to function effectively".


As store manager Jennifer Worley walked through the produce section of the new Walmart Neighborhood Market at 3533 Broad River Road, she stopped to remind employees how to stack red leaf lettuce in the display counter.
Opened in February, Wal-Mart’s small-format grocery with some 41,000 square feet under roof is one of the newest retail outlets to arrive in the Midlands, and Worley and her staff aim to make a good first impression.
Indeed, it seems that almost every week there’s a new grocery, bar, restaurant or pizza joint announcing a grand opening.
“Retailers are expanding at high velocity given the improving economy and increased consumer spending, driving the greatest level of construction seen in recent years,” according to a Colliers International retail space report by Jessica Rahal, research coordinator.
The investment of retailers, many of whom are opening their first locations or expanding within the market, is putting a squeeze on available space. That has prompted new construction and redevelopments while rental rates – specifically for junior anchor and shop space – are climbing, Colliers reported.
At year-end the vacancy rate for the Columbia market was 8.5% compared with 8.7% for the end of 2014. However, the slight change in vacancy “is misleading as many retailers are preleasing space in planned and newly constructed shopping centers,” the report said. “Also, a majority of the retail space remaining vacant is located in older shopping centers.”
Columbia appears to offer plenty of potential for retailers wanting to grow their business.
“We’ve been looking in Columbia for a while,” said Robert Maynard, CEO and co-founder of the N.C.-based Famous Toastery, which will open its first Midlands breakfast restaurant in the former Moe Levy’s building at Lady and Assembly streets. “We’ve been watching downtown for some time and we’ve really seen a transformation down there.”
Another newcomer to the market is Newk’s Eatery, which in November opened at 707-A Gervais St. in the Vista’s City Market redevelopment. Also located in the redevelopment are two other newcomers to the market, Grill Marks and The Wired Goat. A brewery remains under construction and additional space is available for retail or office use.
The Columbia market is ripe with potential for Newk’s, said Chris Newcomb, co-founder and CEO.
“We believe our re-thinking of fast-casual — with an emphasis on dynamic flavor, supremely fresh ingredients and creative, homemade recipes — will appeal to Columbia’s families, downtown workers, food enthusiasts and die-hard Gamecock community,” Newcomb told the Shelby Report, a publication for the food and grocery industry.
Although Wal-Mart superstores have been in the Columbia area for decades, the Broad River location is the first of three Neighborhood Markets the national retailer plans to open in Richland and Lexington counties. Other neighborhood stores are being built at Knox Abbott and Charleston Highway in Cayce and at the intersection of Old Barnwell and Emanuel Church roads in Lexington County. In November, the company opened a Neighborhood Market in Sumter.
“Our Neighborhood Market stores give our customers quick and easy access to a wide variety of affordable products – fresh produce, a full grocery department with a bakery and deli,” said spokesman Phil Keene.
Wal-Mart launched the Neighborhood Markets concept in 1998 as a smaller-footprint option and operates more than 600 Neighborhood Markets, said the stores average 38,000 square feet and employ approximately 95 workers.
Here are other highlights from the Colliers retail report of what’s happening around the area:
- West End Alley is under construction across the street at the 700 and 800 blocks of Gervais Street. City Bar and Fondue will be joining the new restaurant at the development. Additional tenants include Wet Willie’s, Tsunami and Rocketman.
- Exterior renovations have been approved for the former fire station in the Vista near the University of South Carolina Alumni Center. The building will offer up to 35,000 square feet of commercial space.
- A Kroger Marketplace is under construction at Killian’s Crossing at I-77 and Killian Road. Other tenants at Killian’s Crossing include Chick-fil-A, Applebee’s, McDonald’s, and Panda Express. The lifestyle center is located at I-77 and Killian Road and offers 400 acres of retail, residential, and commercial space.
- The Fresh Market plans to open a new store at Two Notch Road and Forest Avenue, near the Village at Sandhill. The 25,000-square-foot store will anchor a new 37,000-square-foot center to be called The Shoppes at Two Notch and is expected to open in the fall.
- Landmark Square Shopping Center at I-77 and Garners Ferry Road recently underwent a major facelift. Ross Dress for Less and Burke’s Outlet are the shopping center’s newest tenants. Goodwill, which is also located at the center, is expanding its store.
- A redevelopment also was completed this year on Park Terrace Drive in the Harbison Boulevard retail corridor. The retail center is anchored by Guitar Center and Academy Sports. Blaze Fast-Fire’d Pizza recently opened its first South Carolina restaurant at the location. Additional retailers include Salsarita’s, Sports Clips, and Title Boxing Club.
- A new retail center is complete at Forest Drive and Percival Road. Tijuana Flats recently opened its first Columbia location at the development. Other tenants include Panera Bread, Wing Stop, PetCo, and Mattress Firm.
- Costco is building a store at Piney Grove and Fernandina roads near the Harbison shopping district.
- Construction has begun on a new Sam’s Club at Fashion Drive and Forum Drive in the Village at Sandhill. The 136,000-square-foot warehouse superstore will be the company’s third Columbia location.
- A 108-room Aloft hotel is under construction on Lady Street across from the new Hyatt Place hotel.
- The Clarion Hotel on Gervais Street is being converted into a dual-branded Hilton Garden Inn/Home2 Suites hotel. Upon completion, the hotel will offer 230 guest rooms.
Published in Feb. 15, 2016 issue of Columbia Regional Business Report


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In this new age of the online world, people have found it easy to get all the required commodities in just a click of their button. New technology inventions are made so that coming time people will have less stress about acquiring their desired products. Out of these technological advances, the most recent ones are the availability of medicines online. Most pharmacies are listing out their medicines online so that people can buy them in just a click of a button. While most of the medicines from new to old are almost made online to buy, there is an increased risk associated with these medicines. One needs to give at most care when it comes it buying these medicines online buy reading all the information related to the medicines and also to know if the particular website is registered according to Indian law. While these online portals are garnering more customers, there is still a large amount of audience which still goes out to pharmacies to buy their prescribed medicines. One can easily pull out their phone and search nearby medical store to get the accurate information of the pharmacies surrounding their area. It is also important to those who are buying these medicines online to know about which is their nearby medical store in times of emergency
Out of our day to day lifestyle, people consume every type of food which they find tasty. But less they care about the essential minerals and mainly the proteins that are needed to build the blocks of healthy physique. Carbs can be acquired almost by every food that we eat, but what it is difficult to gain is the amount of protein that our body needs to sustain our bodily activities. B protein one of the essential protein types is hugely responsible for maintaining a healthy body. B protein facilitates our body with prevention of cell damage, control in blood pressure, leg pain due to blocked arteries, chest pain, cancer, coronary heart disease and many more. B protein intake in finding very less in our daily food, but one can have the desired amount of B protein by consuming it in the form of B protein powder that is available on the pharmacies across places. B protein powder is enriched with Antioxidants and Vitamins as highly active ingredients. It takes over your body by preventing cell damage and avoids any type of causes that affect cell damage. Quality protein intake is necessary for a particular diet which will eventually make a huge difference in one’s health and the best of the quality is analysed by PDCAAS (Protein Digestion Corrected Amino Acid Score).
It is important that one should get all the required prescribed medicines in a course of time but many fail to do so because of the unavailability of pharmacy facilities. Wellness forever is putting all these problems aside as they are opening their pharmacy is more remote areas so that people can get used to their nearby medical store facilities by providing them with good health care.

domain: medical


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Reminder: Be on the lookout for red flags of a scam when shopping online(WDAY TV) - The giving holiday season is when many criminals want to take your money when shopping online.
By: WDAY Staff Reports, WDAY
A few things you should know:
Authorities say you should look for red flags of a scam when buying things on Craigslist, Ebay and other online sites like if the seller will not meet with you, vague descriptions of the item you're buying, or information about the seller or item is wrong.
“They're asking for these money orders, but for whatever reason the person speaking with them through e-mail or voice conversations are able to overcome that, or those suspicions these people have.”
The FBI handles millions of internet scams during the Holiday season each year.

domain: finance


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Spice blends were one of the challenges I discovered when our son first became gluten free. There are a lot of Mexican seasoning blends that have gluten in them as a filler. That hidden gluten became something I needed to watch for.
It became easier much of the time just to make my own. Taco seasoning is the Mexican spice blend I use most often because my family loves these flavours, so I make it in huge batches and freeze it in a resealable freezer bag.
The gluten free taco seasoning recipe I’m sharing today is for a small amount of taco seasoning. I actually times it by 8 or 10 because it’s just as easy once I have all the ingredients out to make it all at once.
Gluten Free Taco Seasoning
Gluten Free Taco Seasoning Recipe:
1 Tbsp. chili powder
1 1/2 tsp. ground cumin
1 tsp. paprika
1 tsp. sea salt
1 tsp. black pepper
1/4 tsp. garlic powder
1/2 tsp. onion powder
1/4 tsp. crushed red pepper flakes
1/4 tsp. oregano
If you like things on the spicier side, you can increase the crushed red pepper flakes or add a bit of cayenne pepper.
How To Make Gluten Free Taco Seasoning:
- Mix all the ingredients together in a bowl.
- Store in a resealable bag or airtight container. I keep mine in the freezer.
(please note that the picture is this recipe times 8)
Another benefit of making your own gluten free taco seasoning mix is that you are able to control how much sugar (in this case, none) and how much salt go into it. I always have more peace of mind when I’ve made something myself because I know exactly what ingredients went into it.
Recipes That Use Gluten Free Taco Seasoning:
More Gluten Free Recipes:
Gluten Free Freezer Crockpot Meals
- 1 Tbsp. chili powder
- 1 1/2 tsp. ground cumin
- 1 tsp. paprika
- 1 tsp. sea salt
- 1 tsp. black pepper
- 1/4 tsp. garlic powder
- 1/2 tsp. onion powder
- 1/4 tsp. crushed red pepper flakes
- 1/4 tsp. oregano
Mix all the ingredients together in a bowl.
Store in a resealable bag or airtight container. I keep mine in the freezer.
Leah Courtney says
This is great! I’m gluten free, and it is more reassuring to just make things myself. 🙂
Mr T says
Are there any directions on use of the Taco Seasoning for beef Taco’s?
Norene Prunty says
I tried this recipe because of a low sodium diet that I must be on for some tests. Very good, but cut the sodium to a 1/4 tsp. and didn’t add the red pepper flakes , which you can add for more spice. We thought it was spicy enough without the red pepper. This will be a keeper!

domain: food


As technology continues to boom, interconnectivity between devices enables the rapid growth of automated homes. The development of the vacuum robot came about as a result of the convenience of manipulating home equipment through wireless connectivity and remote accessibility.
A vacuum robot eliminates the need for manual floor cleaning by setting schedules to ensure a consistently clean home. In addition to convenience and time savings, these compact vacuum robots – unlike traditional, hefty vacuums – relieve the strain of running a vacuum by easily reaching tough nooks and crannies associated with furniture, walls and corners.
To maximize the floor space cleaned, a vacuum robot must optimize its running time. Thus, a battery-charging solution requires astute consideration in vacuum robot design. Taking an input voltage of approximately 19-20V from a charging dock, most vacuum robots on the market employ rechargeable four-cell lithium-ion (Li-ion) batteries to power their systems. Extending the run time of these batteries and cutting battery costs requires efficient utilization of the battery pack to its fullest capacity. Figure 2 illustrates the vacuum robot system and highlights its battery-management solutions.
Figure 1: Vacuum robot system power diagrams
You can implement the charging circuit in several ways. The discrete solution uses a simple DC/DC converter to charge the battery. The system’s microcontroller (MCU) mimics a CC-CV charging curve by controlling the on/off switching of the MOSFETs. While the discrete solution may be inexpensive, its inaccurate charge voltage, low switching frequency and lack of built-in battery protections contribute to additional costs and poorer performance than a charger integrated circuit (IC).
Alternatively, charger IC solutions offer high charge voltage accuracies, high switching frequencies and enhanced battery protections. While some designers may choose a discrete solution with a lower cost than the charger IC solution, the benefits of a charger IC impressively outweigh the price difference.
Vacuum robots on the market vary in run time, ranging from about 60 to 150 minutes. Maximizing the amount of cleaned surface area relies on the robot’s operational period, making optimal run time a key selling point for consumers; just several extra minutes could make the difference between an entirely clean and partially dirty home.
TI’s charger IC such as the bq24725A or bq24610 offers a high-accuracy charge voltage of ±0.5% compared to a low-cost DC/DC converter charge voltage accuracy of ±5%. Due to the small ±0.5% charge voltage accuracy, this charger IC maximizes battery capacity, which ultimately extends the robot’s run time.
Figure 3 describes the battery voltage versus the depth of discharge (DOD) of a 4.2 Li-ion battery at room temperature. Based on the charge voltage accuracies of the charger IC and several discrete solutions, the data maps several DOD points to battery voltages, which translate to run time. As shown in Figure 3 and its associated data in Table 1, the TI charger IC solution significantly maximizes capacity over discrete charging solutions.
Figure 2: Li-ion DOD versus battery voltage
Table 1: Charge voltage accuracy mapped to battery capacity
Battery capacity ultimately translates to device run time and the cost difference of batteries with a certain run-time goal. For example, take a vacuum robot that uses a TI charger IC solution with ±0.5% charge voltage accuracy that runs for 120 minutes. The same vacuum robot using a DC/DC converter as a discrete solution with a charge voltage accuracy of ±5% would only run for 55 minutes. Therefore, the loss in capacity due to a less accurate charge voltage, as shown in Table 1, significantly diminishes the run time of the robot.
From a monetary standpoint, a battery pack for this application costs about $20. The 56% capacity lost in this example requires you to purchase $11 more in capacity. This extra 65 minutes of run time would allow the robot to clean several additional rooms, and the cost savings due to maximized capacity quantifies the value of using a charger IC solution.
Charger IC solutions yield high switching frequencies and in turn require small, low-cost inductors. For example, TI’s bq24725A, with a switching frequency of 750kHz, typically uses a 4.7µH inductor sized at 28mm2. Alternatively, a discrete solution with a switching frequency of only 50kHz requires a larger, 75µH or greater inductor covering about 113mm2 of board space. Along with saving solution size, the charger IC’s inductor is roughly two times less expensive than the discrete solution’s inductor, depending on inductor choice.
From a design perspective, a charger IC advantageously offers a complete, sophisticated suite of battery safety features, including input overcurrent, charge overcurrent, battery overvoltage, thermal shutdown, battery shorted to ground, inductor short and field-effect transistor (FET) short protections. On the other hand, a discrete solution would have to use its MCU to implement battery protections, and damage could occur to the battery by the time the MCU detects faults due to its slow response times. Therefore, a charger IC protects the battery in any worst-case scenarios while eliminating the need for you to create your own battery protections.
For additional design flexibility, the TI multicell switching charger portfolio provides options for stand-alone and host-controlled topologies. A stand-alone charger such as the bq24610 controls voltage and current limits with external circuitry elements, facilitating simple implementation. A host-controlled charger such as the bq24725A or bq24773 uses I2C or SMBus to program the limits, saving bill-of-materials cost by employing the calculating power of the system’s already-existing MCU.
A charger IC offers a myriad of advantages over common discrete charging solutions for vacuum robots. Although a discrete solution may be more economical initially, a charger IC solution provides a significantly longer run time, system cost savings and a simpler design implementation than the discrete alternative. Ultimately, the benefits of the complete charger IC solution outweigh the initial cost savings of the discrete charging solution.
- Find resources and reference designs for vacuum robots here.
- Explore high efficiency battery charger ICs like bq24725A, bq24773 or bq24610
- Don’t forget to consider battery capacity indicators as well. Read this blog for advice on fuel gauges.
- Read the white paper, "Achieving increased functionality and efficiency in vacuum robots."


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Okinawa's 'Miracle Coral'
Feb. 20, 2017
The world's coral reefs are under threat due to rising water temperatures, but a new discovery in Okinawa could reverse the tide.
Coral reefs provide marine life with vital habitat and spawning grounds. Known as 'the cradle of life in the ocean,' experts say one in 4 of the world's marine creatures rely on them for their survival.
Now coral reefs are threatened by rising water temperatures, which lead to bleaching, a process that turns them white and eventually kills them. But findings by a marine biologist in Okinawa may help preserve coral reefs and save oceans from crisis.
Sekiseisyouko, the largest coral reef in Japan, used to be a paradise of colorful coral, and had fish swimming everywhere. But more than 90 percent of it has succumbed to bleaching
The devastation of coral reefs around the world is blamed on the rise of ocean temperatures last year. During the summer, waters near Ishigaki topped 30 degrees Celsius, and the extremely-high temperatures continued for nearly 2 months.
Within the tissue of corals there's a phytoplankton named zooxanthellae. It feeds the coral and gives them color, but when coral has to endure rising water temperatures and strong sunshine, their tissue loses zooxanthellae. This causes 'coral bleaching,' and eventually death.
Bleached corals are seen throughout the sea of Okinawa. But right next to the bleached ones, an NHK team observed some that still had their original color. The corals that did not suffer from bleaching were grown at a farm in Okinawa.
Koji Kinjo is an expert in coral farming. He's been working to restore marine invertebrate to the ocean for nearly 20 years. Coral that do not bleach are Acropora tenuis, and they are abundant in Okinawa. Kinjo spent years adapting them to withstand a harsh environment.
He had a eureka moment at an event to teach about coral spawning 7 years ago. Kinjo moved coral from a deeper part of a water tank to a shallower place, so that children could observe the spawning process more easily. Many of the coral bleached and died because of exposure to sunlight, but some recovered.
He selected and bred the surviving corals and moved them to an even shallower place, allowing them to gradually get used to the new environment. He repeated the process over a period of 4 years and found that his coral didn't bleach, even when exposed to intense sunlight.
Kinjo tried replanting them at sea, and found they could withstand warm water temperatures. He had succeeded in creating coral that were immune to bleaching -- something that was unprecedented.
"It's like a miracle happening. I've been farming corals for 18 years, but nothing like this has ever happened. It's miraculous," Kinjo says.
Research is underway to identify what exactly prevents coral from bleaching.
Yoshikatsu Nakano, a coral reef expert at the University of the Ryukyus, and a team of researchers have been comparing and analyzing coral that do and do not bleach from a variety of angles.
They found no difference between them in terms of the zooxanthellae in their tissue. But they found something that was different in the coral that didn't bleach: plenty of a bacterium called endozoicomonas.
"Something is happening to the bacteria. It's become increasingly evident that the bacteria have something to do with the intensity of bleaching. It's still a small but an important step," says Nakano.
Coral that resist bleaching were created in Okinawa and Kinjo hopes to grow more of this type of coral, and help restore the coral reefs in his hometown.
"When I was a child diving in the waters of Okinawa, it was like watching full-color, high definition TV. But when I dove into the water just recently, it was almost like black and white. But my recent experiment has given me confidence that we can bring back life, marine creatures," he says. "This may be a dream but we definitely want to win the battle on climate change."
The bleaching is now a growing global concern but this discovery could be part of a solution to revive coral reefs around the world.

domain: geography


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2,000 psi fill pressure. Up to 50 shots per fill in.
177 / 35 shots in. Air reservoir ends with a male quick-disconnect Foster fitting for fast refills (requires a female Foster quick-disconnect adapter to fill from a scuba tank or hand pump). Tech Tip: When mounting a scope with a 40mm objective lens or larger, it may be necessary to remove the rear sight.


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The fascinating thing you learn is nobody cares, but I don’t mean that in a negative way. We’re always thinking of what people think of us, but nobody cares.
If you have 34 minutes to spare today, we highly recommend watching the latest short film by music blog La Blogothèque. True to La Blogothèque form, the globe-spanning piece is shot using lo-fi production, producing raw and evocative live musical footage. The short is an homage to the jazz label Blue Note, which celebrates its 75th anniversary this year, featuring Ones To Watch artist Moses Sumney, Patrick Watson, Mondkopf, and Dirty Beaches’ Alex Zhang Hungtai performing their rendition of a classic jazz piece. Each segment opens with the artists reflecting on a specific music memory before performing an acoustic set. Order of appearances below:
1. Patrick Watson - “Summertime”
2. Moses Sumney - “Moanin”
3. Alex Zhang Hungtai - “Blue Train”
4. Mondkopf - “Turning Point”

domain: entertainment


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Millennial-scale changes in North Atlantic Deep Water circulation during marine isotope stages 11 and 12: Linkage to Antarctic climate
Geography and Geology
The time interval represented by marine isotope stages (MIS) 11 and 12 (ca. 360-470 ka) may contain the most extreme glacial and interglacial climate conditions of the late Pleistocene. Sediments from the Bermuda Rise (western North Atlantic) provide clues to the nature of climate variability during this period. Our geochemical records indicate that millennial-scale climate instability and associated changes in North Atlantic Deep Water (NADW) production occurred during both interglacial MIS 11 and glacial MIS 12, Stage 12 is punctuated by a series of interstadial events that occurred at a 5-6 k.y. periodicity, and the occurrence of ice-rafted debris at various times during stage 12 indicates that icebergs were present at least as far south as 34 degrees N during this glacial period. Within the limits of our correlation, the atmospheric temperature changes recently reported for the Vostok ice core for the stage 11 time period appear to be represented by coeval changes in NADW flow. Specifically, warming in Antarctica is associated with increased production of NADW.
Link to Published Version
Poli, M. S., Thunell, R. C., & Rio, D. (2000). Millennial-scale changes in North Atlantic Deep Water circulation during marine isotope stages 11 and 12: Linkage to Antarctic climate. Geology, 28(9), 807–810. doi:10.1130/0091-7613(2000)28<807:MCINAD>2.0.CO;2


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HighNote CD 7164
A Night in the Life- Live at the Jazz Standard Vol. 3
Alto saxophonist Frank Morgan remains one of the coolest bebop players and an inspiration to all. The legend of his losing three decades of his musical career to drug abuse and incarceration, followed by a significant return, has already been retold too many times. Morgan's HighNote albums remain a study in lyricism, swing and, in a word, the very best of the lifelong lessons imparted by his mentor, Charlie Parker. With many of the tunes chosen for this session written by Parker or played by him, A Night in the Life brings Frank Morgan full circle. From his early days under Bird's spell, through the long and arduous road leading to his 1985 re-emergence and renaissance, Frank Morgan's latest release is a personal statement, a summation, a look back while moving forward. As such it is an invaluable document of one of jazz's most creative artists.
Featuring Frank Morgan- alto sax; George Cables- piano; Curtis Lundy- bass; Billy Hart- drums.
Tracks: Confirmation; On Green Dolphin Street; Half Nelson; Hot House; Billieís Bounce; Itís Only a Paper Moon.
Back to Frank Morgan


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Make the winter blues go away and put the smile back on your face! This healthy and delicious hot chocolate recipe, filled with the goodness of superfood, is all you need to keep yourself warm, cozy and happy this winter season.
Check out the recipe to make this hearty cup of true happiness.
Top it with marshmallows, drink hot and enjoy the season! 😋
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Thousands of Harry Potter fans gathered at the Hollywood Bowl on June 29 as the Philharmonic Orchestra brought Harry Potter and the Order of the Phoenix to magical, musical life. The show was part of the global Harry Potter Film Concert Series tour and the fifth Harry Potter film installment at this location. Dressed up in character costumes and Hogwarts house robes, fans gathered under the stars for more than just a movie; we were there for an immersive, live experience celebrating the Harry Potter fandom.
If you are fresh out of Felix Felicis potion and haven't been lucky enough to attend any of the Harry Potter films in concert yet, you might be asking what’s so remarkable about these shows. As one of your Harry Potter Fan correspondents, SYFY WIRE sent me to investigate!
As many Harry Potter fans know but often forget, the music is what brings these movies to life and binds this magical world together. We so often forget to take the time to consider the careful depth, attentive details, and hard work that goes into every spellbinding note of each film. The Harry Potter in Concert series not only provides an opportunity to visually watch each individual instrumental sound take shape on the stage in front of you, but allows the viewer to line it up with the film as you watch it. This offers a whole new appreciation for productions in the arts. You might even be inspired to pick up a flute or learn to play the harp yourself.
But before the event began, I was granted a special opportunity to step backstage and interview Sarah Hicks, who would be our conductor of the Philharmonic Orchestra for the evening's performance. In an industry traditionally dominated by men, Hicks proves a charming, multi-talented individual with an influential story of defying the odds and pursuing your passions.
In her youth, Hicks was a talented concert pianist until an injury forced her to switch directions and settle into conducting. Hicks says the music world is far more accepting if you are good at what you do and show up confident, ready to go, and ready to work. As a Potter fan herself — and a fellow Gryffindor — she explained the uniqueness of the Harry Potter concerts.
"There's more of a universe to the Harry Potter series, where people come dressed in costume and cheer for their house pride during these shows," she says. "It's nice that there is a world that everyone can enter, and be a part of here."
The Hogwarts pride is so strong that select members of the Orchestra represented their houses by wearing robes during a rehearsal. Hicks had her own Gryffindor scarf waiting backstage, guarded by her adorable little Papillon dog Pinkerton.
Fans of Harry Potter tend to establish quick friendships, and this event was no exception. We sat down and discussed how our mutually favorite film score is from the third installment, Harry Potter and the Prisoner of Azkaban, and dived into our appreciation for Harry Potter's beloved master of cinematic scores, John Williams. Hicks recalled that she once did a gala concert in honor of Williams, during which she had the opportunity to conduct Harry Potter music with him in attendance.
"I wasn't nervous; it was just another week on the job where a composer I adore just happens to be there," she explains.
While conducting, Hicks pushes all her emotions aside to remain focused on a variety of highly detailed screens and visualizers to keep the orchestra in time with the film. Nevertheless, she highly encourages fans to be involved in the emotions of the films, cheering for their favorite characters or shouting and booing at the villains together.
This event, brought together by CineConcerts, provided more than a viewing of a movie we've all seen on repeat. It was a safe event space for the community to meet new friends, loudly shout our anger at Umbridge, and express our gasps of admiration at a Patronus charm.
Be sure to check out the list of future dates and locations below as CineConcerts continues its world tour of the Harry Potter film concert series. To learn more about the film concert series, visit www.harrypotterinconcert.com


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Stephen Bear has been crowned the winner of Celebrity Big Brother.
Yet despite winning the public vote, the controversial contestant exits the house to a chorus of boos.
‘Ex On The Beach’ reality TV star Stephen is certainly dressed for a day at the seaside, wearing a garish Hawaiian T-shirt and short shorts, as he greets the rowdy crowd and the show’s host Emma Willis.
But at least one person in the audience is on Stephen’s side.
His glamour model girlfriend Chloe Khan, who hooked-up with him as a contestant on the show, cannot hide her delight at her BF’s victory. She is uncharacteristically covered-up in an elegant emerald floor-sweeping high-necked dress.
Another couple reuniting at London’s Elstree Studios is Marnie Simpson and Lewis Bloor.
Finishing a respectable fourth, ‘Geordie Shore’ celeb Simpson opts to go bra-less in an eye-catching semi-sheer jumpsuit.
The Channel 5 show always attracts controversy, with fans this time taking to social media to accuse bosses of staging scenes in the competition.

domain: celebrity


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Golf Leaders Experiment With 15-Inch Holes NBA Notes Silver Reiterates Desire On Raising Age Limit NBA Playoff Seeding Not Silver's Focus Bettman Praises Shanahan's League Office Work NWSL Eyes Elusive Stability, Viability Judge Denies NFL Concussion Settlement Selig Praises New Replay System Production Dips For Some NHL Clubs Post-Olympics Vikings, Twins Owners Want Expansion MLS Club
Upcoming Conferences and Events
Noonan! Golf Industry Leaders Experimenting With 15-Inch Holes To Drive Interest04 / 22 / 14
An "internal rebellion" in golf has led to alternative forms of the game with "new equipment, new rules and radical changes to courses," according to Bill Pennington of the N.Y. TIMES. The goal is to "alter the game’s reputation in order to recruit lapsed golfers and a younger demographic." Am...
"Four of pro basketball''s greatest all-time stars, admitting disgust and embarrassment over the NBA lockout, yesterday angrily ripped a handful of player agents as the forces behind the current labor
After a meeting with NFL Commissioner Paul Tagliabue, MD Gov. Parris Glendening "said he does not believe the league will expand any time soon." Glendening, who added that the meeting "cleared the air
The Mavericks'' first summer mini-camp "has been canceled without any announcement," according to Brad Townsend of the DALLAS MORNING NEWS. Townsend: "The Mavericks had considered issuing a news relea
The LPGA held a roundtable discussion yesterday at their JAL Big Apple Classic in New Rochelle, NY. Among the speakers was outgoing Commissioner Charlie Mechem, and future Commissioner Jim Ritts. Mech
Yesterday, at a New York City Hall press conference to launch "Hoop it Up 1995," Knicks center Patrick Ewing "said he was tired of hearing that a select group of agents are behind part of the league''
South Korea''s top soccer official ruled out the possibility of co-hosting the 2002 World Cup with Japan, according to KYODO NEWS. South Korean Soccer Federation President Chung Mong Joon said South K
NBA players would be "crazy" to disband the NBPA, according to Spurs forward Sean Elliott in this morning''s SAN ANTONIO EXPRESS-NEWS. In a report by David King, a number of NBA players, in San Antoni
A Federal Appeals Court upheld the NFL''s right to black out games that are not sold out. A Cleveland man who is hearing- impaired sued the NFL, the Browns and Cleveland''s network affiliates charging
The NBA lockout is "reaching into the wallets of corporate America," according to Peter May in yesterday''s BOSTON GLOBE. May reports that on Friday NBA teams were told the league canceled its biennia
Throughout the first half of the season, weekend columnists and pundits have expounded on the dire state of baseball, but that attitude took a hit this weekend as several opinion-makers took swings at

domain: sports


With a general election set to take place on 8 June, it is important you register to vote and then use your vote on the day.
Hundreds of thousands of people could be disenfranchised by failing to register in time
When is the deadline to register to vote?
Assuming you are eligible, you can register any time but, be aware, there will be a deadline. The deadline to register for the last general election was 12 working days before people went to the polls. Assuming we follow the same timetable this time around, the deadline would be 22 May.
If you are already on the electoral roll you do not need to register again and your local authority can tell you if you are already on the register. If you voted in the EU referendum in 2016 (and haven't moved) you are most likely already on the list.
If you're not on the electoral roll, register to vote on the government's gov.uk website. On the 'Register to vote' page it is possible to update a name, address and other electoral register details, choose whether you want to vote by post or in person, and change whether you are on the open register.
For more information read the BBC general election guide.
It takes five minutes to register and, when doing so, you'll need your National Insurance number. If you're a British citizen living abroad you will also need your passport.
Why you should register and then use your vote:
- Things never have to stay the way they are. If we give up, change will never happen
- They are your public services, you decide their future
- If you don't vote, you don't count
- Being registered to vote improves your credit rating. Immediately.


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Invisible Fence for your Pet
How it works.
Your Invisible Fence Brand professional installs a durable, discreet cable around the perimeter of your property to creat an Invisible Boundary area.
A transmitter, usually placed in your garage or basement, sends a digital radio signal along the cable.
That signal is picked up by your pet's custom Computer Collar Receiver. Should he forget or test his limits, the Collar delivers a warning tone as he approaches the Invisible Boundary area. If necessary, it provides a gentle but effective static correction, so he knows he's gone too far.
Their certified trainers use positive reinforcement to teach your pet where he can and can't go. That way, your dog or cat understands, and stays within the boundaries you establish.
Contact a representative today! 585-271-1700 720 Westfall Rd Rochester, NY 14620

domain: pet


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Booting a kernel on CF or Hard disk
Is there a bootloader - like the "x86 BIOS boot" - for ARM that can boot kernels on the hard disk? Any suggestions are welcome. I want to use it on a D-Link DNS 323. Reflashing the kernel using the serial port takes too long and requires another machine and a serial connection.
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Mailbox Monday is the gathering place for readers to share the books that came into their house during the previous week. Warning: Mailbox Monday can lead to envy, toppling TBR piles and humongous wish lists! Mailbox Monday is being hosted by Serena at Savvy Verse & Wit for the month of October.
Here is what I received last week:
Jane Austen Made Me Do It: Original Stories Inspired by Literature's Most Astute Observer of the Human Heart by Laurel Ann Nattress
(Received from Random House for review)
SYNOPSIS: “My feelings will not be repressed. You must allow me to tell you how ardently I admire and love you.” If you just heaved a contented sigh at Mr. Darcy’s heartfelt words, then you, dear reader, are in good company. Here is a delightful collection of never-before-published stories inspired by Jane Austen—her novels, her life, her wit, her world.
In Lauren Willig’s “A Night at Northanger,” a young woman who doesn’t believe in ghosts meets a familiar specter at the infamous abbey; Jane Odiwe’s “Waiting” captures the exquisite uncertainty of Persuasion’s Wentworth and Anne as they await her family’s approval of their betrothal; Adriana Trigiani’s “Love and Best Wishes, Aunt Jane” imagines a modern-day Austen giving her niece advice upon her engagement; in Diana Birchall’s “Jane Austen’s Cat,” our beloved Jane tells her nieces “cat tales” based on her novels; Laurie Viera Rigler’s “Intolerable Stupidity” finds Mr. Darcy bringing charges against all the writers of Pride and Prejudice sequels, spin-offs, and retellings; in Janet Mullany’s “Jane Austen, Yeah, Yeah, Yeah!” a teacher at an all-girls school invokes the Beatles to help her students understand Sense and Sensibility; and in Jo Beverley’s “Jane and the Mistletoe Kiss,” a widow doesn’t believe she’ll have a second chance at love . . . until a Miss Austen suggests otherwise.
Regency or contemporary, romantic or fantastical, each of these marvelous stories reaffirms the incomparable influence of one of history’s most cherished authors.
Also includes stories by Pamela Aidan • Carrie Bebris • Diana Birchall • Monica Fairview • Janet Mullany • Jane Odiwe • Beth Pattillo • Myretta Robens • Jane Rubino and Caitlen Rubino-Bradway • Maya Slater • Margaret C. Sullivan • and the winner of a story contest hosted by the Republic of Pemberley website
For those readers not in the know, Jane Austen Made Me Do It's author is none other than Austenprose's own author/editor. Please be sure to visit her site!
What goodies arrived in your mailbox last week?

domain: library


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Football teams in Europe build their squads by buying players during the summer transfer window, which fascinates football fans across the world. Despite the coronavirus epidemic, Europe's top clubs are hoping to add superstar players during the summer transfer window this year. Lionel Messi has already signed a two-year contract with PSG in Ligue 1, and Chelsea have acquired Romelu Lukaku for 115 million euros from Serie A champion (2020/2021) Inter Milan. Erling Haaland, Kylian Mbappe, Cristiano Ronaldo, Harry Kane, and Kylian Mbappe are all available for a new challenge. Let's look at some of the latest summer football transfer news in 2021.
Transfer Rumours: Potential Transfers Before the Deadline
PSG signed one of the greatest ever footballers, Lionel Messi earlier this month with the aim of creating a strong attacking line-up in Europe with Neymar, Mbappe, and Messi upfront. However, their wish may not be fulfilled because Mbappe has reportedly declined to extend his current deal with the Paris-Saint Germain.
According to rumors, he is considering leaving the club for Real Madrid this summer. He has also no worries about finishing his current contract, which will expire at the end of the 2021/2022 season. Real Madrid have officially made a 160 million euro offer to PSG to lure Mbappe to the Santiago Bernabéu.
PSG's Director of Football, Leonardo, has confirmed that he would not be sold for a low price. Various reports claim, any team interested in acquiring Mbappe this season will have to pay 220 million euros. In the coming days, this Mbappe transfer saga may take some unexpected twists.
The agent for Cristiano Ronaldo, Jorge Mendes is now working on a transfer for his client. Ronaldo may be forced to finish his present deal with Juventus if he cannot find a suitable club. Earlier, PSG had expressed interest in luring Cristiano Ronaldo if Mbappe left the club. However, according to recent rumors, Paris Saint-Germain are no longer interested in purchasing him this summer.
So, Cristiano Ronaldo's only feasible alternative would be to join Manchester City. If he departs Juventus for Manchester City, it would be a huge shock to Manchester United supporters.
Ronaldo established himself as a global superstar during his time with the Red Devils from 2003 until 2009. He also won his first Ballon d'or with Manchester United. As per sources, he would cost around 25 million euros, making this spectacular transfer possible.
Borussia Dortmund forward Erling Haaland is one of the most talked-about players in Europe right now. Since joining German club 2020, this big forward has been in excellent form. All of Europe's major teams are vying for his signature. However, Borussia Dortmund will not sell him for a low price. This summer, Haaland will cost more than150 million euros.
Chelsea attempted to sign him earlier this month, but Dortmund refused to sell him. In the following season, Erling Haaland would be available at a considerably lower price. So, we may expect him to leave next summer rather than this window. Manchester City, FC Barcelona, Bayern Munich, Real Madrid, and Manchester United are the favorites to sign him next season.
Robert Lewandowski has established himself as a legend after spending more than a decade in the Bundesliga. He has set numerous Bundesliga records. He broke Gerd Muller's most goals in a single season in the 2021/2021 season. Lewandowski is eager to leave Bayern Munich in search of a new challenge.
At the age of 33, he can only move to a team that badly need a striker for a limited period of time. For the time being, Manchester City appear to be the best choice for him. PSG might be an alternative if Mbappe leaves for Real Madrid. Because of his age, both Manchester City and PSG can purchase him for a low price. But one thing is certain: he will score a lot of goals wherever he goes.
Harry Kane was keen to leave Tottenham Hotspur in search of silverware. Because he does not feel Tottenham is capable of winning a trophy. Kane was widely linked with a move to Manchester City.
Man City allegedly offered Spurs 125 million pounds for Kane, but Daniel Levy, the Spurs chairman, turned down the offer. As per reports, they are seeking more than 150 million pounds.Finally, Harry Kane has confirmed that he will not leave Tottenham this summer, and he is allegedly demanding a weekly salary of £400,000 from the club. It will be interesting to see whether Man City make a January transfer window move for Harry Kane.
According to the latest transfer news, some big signings might be completed before the end of the summer transfer window 2021. The window will end at midnight on August 31st, giving teams less than a week to execute their desired deal. As per the latest transfer rumors, Cristiano Ronaldo and Kylian Mbappe are the most likely to leave their present clubs for a new challenge. Their transfer will affect the equation in terms of Champions League football. So, the next few days of this transfer window are crucial for all of Europe's big clubs.


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Fresh Bruschetta Recipe
- 4 tomatoes
- 1 tsp garlic, mashed
- 2 tbsp extra virgin olive oil
- 1/3 cup basil leaves, chopped
- Few mint leaves, chopped
- Cut 3 tomatoes in half, place on baking tray and drizzle with a bit of olive oil and salt/pepper. Roast 20 mins.
- Remove and cut out seeds/juice then chop. Put in bowl and add the 4th tomato chopped fresh.
- Add extra virgin olive oil, garlic, basil and mint. Marinate at room temperature for 1-2 hours.
- Serve on hot bread and top with salt/pepper Parmesan cheese.


You may have heard the term blockchain technology” before, in reference to Bitcoin and other cryptocurrencies For the uninitiated, the term might seem abstract with little real meaning on the surface. The blockchain is a technology that is predicted to have large implications for industries like finance, health, government, medicine, manufacturing, logistics, transportation, and more. We see blockchain something we can build other things upon and allow users to do whatever they want with it for free.
However, working directly with the blockchain provides a good degree of innovation, for example in building decentralized applications. Retailers that offer them to consumers can dramatically lower costs per transaction and enhance security by using blockchain to track the flows of currency within accounts—without relying on external payment processors.
Moreover, there is no Blockchain network in existence that could sustain the same amount of transactions as major card issuers like Visa or MasterCard do. As of 2017, Blockchain still has a very long way to go before it will be capable of replacing the giants of the financial world.
Blockchain is the technology underpinning it. Each transaction is digitally signed to ensure its authenticity and that no one tampers with it, so the ledger itself and the existing transactions within it are assumed to be of high integrity. Ironically, some of blockchain's most successful companies are fairly centralized middlemen , and many new projects are dogfooding ” the buying and selling of blockchain-based currency by putting the whole exchange on a blockchain.
Blocks record these transactions and make sure they are in the correct sequence and have not been tampered with. Because all transaction logs remain recorded on the blockchain in a distributed manner and are shared by the participants, illegal transactions can be easily detected.
The block is sent out to the bitcoin network, which are made up of people running high-powered computers. So, if someone tells you that the invention of the blockchain can be compared with the invention of the Internet in terms of importance, be skeptical.
Private institutions like banks realized that they could use the core idea of blockchain as a distributed ledger technology (DLT), and create a permissioned blockchain (private or federated), where the validator is a member of a consortium or separate legal entities of the same organization.
The bitcoin blockchain is not really made for companies to build apps and processes on. But a number of other companies have created blockchain platforms to help firms interested in the technology build processes. By allowing digital information to be distributed but not copied, blockchain technology created the backbone of a new type of internet.
IBM and Samsung have been working on a concept known as ADEPT (Autonomous Decentralized Peer-to-Peer Telemetry), which uses blockchain-type technology to form the backbone of a decentralized network of IoT devices. Most businesses that are testing blockchain technology are doing so in a very limited capacity (i.e., demos or small-scale projects).
Nakamoto combined established cryptography tools with methods derived from decades of computer science research to enable a public network of participants who don't necessarily trust each other to agree, over and over, that a shared accounting ledger reflects the truth.
As a result, companies could benefit from the agile financial model that accommodates new technology. The blockchain was born blocktalks blockchain as the digital scaffolding for cryptocurrency transactions. With the open and public ledger, we could put an end to money laundering and other financial crimes.


Plans for a subdivision on the west side of Maryhill, unveiled at a public meeting Tuesday night, have some of the neighbours worried about its impact on existing neighbourhoods and surrounding natural environment.
Sunset Hills Estates (855384 Ontario Ltd.) wants to build 38 single-family homes on a 29-acre (11.8 hectare) portion of a property that totals 82 acres, with 52 acres to remain as agricultural land outside the settlement boundaries. The portion to be developed is within the Maryhill urban area, and has long been zoned for residential development.
In fact, the land has a history of development proposals dating back to at least 1978, director of engineering and planning Dan Kennaley said at this week’s planning meeting. The applicant is looking for zone changes that would see the designation of open space to protect an existing pond and maintain a link to a wetland area to the north.
The lands are on the west side of the village, and would see the extension westward of Zingervilla Place and a link to Homestead Drive, providing two entrances into the subdivision.
The plan of subdivision calls for a 1.5-acre park at the southeast portion of the land, a plot that currently fronts on Homestead Drive.
The lots, a minimum of a half-acre in size, would be serviced by municipal water from the existing system on the east side of Maryhill Road at St. Boniface Drive. The homes would be on private septic systems.
Simon Hasiu, who along with Sasa Filipovic, would develop the project and build the custom homes, said bungalows would start at 2,800 square feet, with two-story houses from 3,800 sq. ft.
Hugh Handy, a planner with the GSP Group, said the goal is to use the rolling topography of the area to the best advantage while protecting the natural features.
“We want to enhance what is there right now, and make sure we protect the natural environment,” he said.
In response to a question from Coun. Bonnie Bryant, Handy said the applicant would be working with the Grand River Conservation Authority to mitigate issues such as road salt’s impact on the environment and providing a corridor for wildlife such as turtles to travel between the two wetlands once a new road is introduced.
The development’s impact on the natural surroundings was front and center for residents who were out at Woolwich council chambers to provide feedback about the project.
Gary Embro, a resident for 38 years, while not opposed to the subdivision, expressed concerns about the effects on groundwater.
The installation of a municipal drain a few years ago led to a marked decrease in the level of the pond, he said, suggesting the subdivision could spell the end of the wetland.
“I predict that that pond won’t be there in five years,” said Embro, noting the current topography allows water to run downhill into the pond. “I’m worried what’s going to happen when that hill is worked on.”
Of the project itself, he predicted it could take 10 or 15 years to build out, a long time for residents to live with the mess, traffic and noise of construction.
For Gord Kaster, who runs a livestock farm to the west of the proposed development, the subdivision brings the prospect of people moving from urban areas looking for a rural lifestyle without realizing that rural life means noisy cows and the smell of manure being spread, for instance. He suggested a system, perhaps in the deeds, to notify homebuyers about the realities of living next to an agricultural area.
He, too, pointed to the potential impact on drinking wells should the project go in, suggesting a collective municipal treatment system would be better than individual septic tanks.
The meeting December 10 was for information purposes only, with council making no decision on the matter. Kennaley noted that all of the issues raised at the meeting would be taken into account when staff assesses the suitability of the project, drafting a recommendation report for councillors at a later date once all feedback has been received.


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$1,506 2 bed 1 Meridian Ln, Reisterstown MD, 21117
Some errands can be accomplished on foot.
A few nearby public transportation options.
Explore how far you can travel by car, bus, bike and foot from The Summit At Owings Mills.
The Summit At Owings Mills has some transit which means a few nearby public transportation options.
87 GLYNDON - OWINGS MILLS
89 ROGERS AVE - OWINGS MILLS
View all Reisterstown apartments on a map.
The Summit At Owings Mills is in the city of Reisterstown, MD. Reisterstown has an average Walk Score of 39 and has 25,968 residents.Learn More About Reisterstown


I’ve got the definitive advice on how to dry clothing, no matter what garments you’re drying, where you live, or what sort of weather it is. Knowing how to dry clothing properly may save you time, worry, energy, and even money.
You’ve come to the correct spot if you’ve been wondering if there’s a better method to dry your clothing. Perhaps I’ll even shave some fresh information with you!
How to Dry Clothes in the Dryer
- Sort the clothing according to their Iight and material.
- Before putting the garments in the washing machine, give them a good shake.
- Don’t overburden the dryer.
- Now is the time to add your dryer sheet, ball, or aluminum foil.
- Select the appropriate option for the fabric type.
- Remove your clothing as soon as possible. They may be folded, hung, or ironed.
This post may contain affiliate links. Full disclosure here.
How to Dry Clothing in the Dryer
If you’re new to tumble drying or just want to be sure you’re doing it correctly, check out these helpful hints. A tumble dryer is especially useful during the winter months when it is too cold to air dry your clothing properly.
Always clean the lint filter before you begin. If you don’t, the dryer might overheat and catch fire. If you have a water tray, empty that as well.
Sort your clothing before tossing them in the dryer. Separate your items if they require a different drying temperature.
For example, dry clothing that can withstand higher heat and clothes that require a low heat together. For a more smooth washing process, do this before washing your items.
Check to ensure that any stains and dirt have been removed once the clothing has been cleaned. Stains can be set by putting stained garments in a hot dryer.
After you’ve examined the garments for stains, shake them thoroughly before placing them in the dryer. This reveals hidden things such as socks and undergarments while also removing wrinkles.
Overloading the dryer might cause it to take longer to dry. There is little space for the garments to move around and dry evenly. I recommend loading your dryer no more than halfway, or 75 percent of the way.
Zip zippers up so they don’t snag. Turn clothes inside out to avoid fading and to maintain the fabric. This is especially essential when it comes to jeans.
Add-In Your Dryer Accessories
If you want to put anything in your tumble dryer, this is the moment. A dryer sheet, wool dryer balls, a tennis ball, or aluminum foil may all be used. All of these products will aid in the production of smooth, wrinkle-free clothing.
Choose the appropriate drying setting based on the sort of garments you’re drying. The care label on the clothing will lead you in the right direction. Some textiles demand minimal heat, while others can withstand greater temperatures.
Cotton and linen, in general, respond well to high heat. Synthetic materials respond well to medium heat. Lingerie and swimwear are best washed on the gentle or low heat cycle.
Some washing machines include an air-dry mode that may be used to fluff up clothing or freshen them.
Remove It Clothes
Remove the items from the dryer as soon as possible to avoid further creases. The garments will be set as they cool, so if you leave them folded up for too long, they will be set with creases.
After you’ve removed them, fold them, hang them up, or iron them.
How to Dry Clothing Without a Tumble Dryer
If you don’t have a tumble dryer or just want to conserve money and energy, I offer a variety of options for you to test.
Remove the garments from the washing machine and place them, one at a time, on a clean white towel. I recommend needing a white towel to avoid color transfer from the towel to the clothing.
Roll the towel and clothing together securely, pushing lightly as you go. This aids the towel’s ability to absorb extra water.
If the garment is dried flat, place it on another dry clean white towel. This towel will absorb extra moisture while the clothing dries naturally.
After the cycle is completed, leave the items in the washing machine. Set the spin speed to high. This eliminates extra moisture, allowing them to air dry faster. This is a quick, easy, and energy-efficient method of preparing clothing for air drying.
Can You Dry Clothes On Spin Cycle
No. The clothing will still be damp, but not as much as it did prior to the high spin cycle. The clothing will dry faster and will smell less.
Making Use of a Hair Dryer
- Hang the item up to dry.
- Turn on the hairdryer to medium heat.
- Move the hairdryer across the clothing while keeping it approximately six inches away from it. Don’t keep it over one spot for too long, since prolonged exposure to this kind of heat might harm the cloth.
- Turn the garment inside out to dry it completely.
- Continue until the clothing is completely dry.
Before you begin, ensure that the item can be ironed. This information may be found on the care label.
- Place the clothing on an ironing board or ironing blanket and iron it flat.
- Set the iron to a low setting.
- Iron the It clothing slowly.
- To iron the entire item of clothing, flip it around and inside out.
- Cover the clothing with a clean white towel and turn the heat to high.
- Iron over the clothing once again to remove any residual moisture.
Drying by Air
Air drying is the most frequent method of drying garments without needing a tumble dryer. You may air dry your clothing either indoors or outside.
Outside is your favorite technique because it is faster. The wind and air movement swiftly dry the clothing. However, you may not have an outside space, or the weather may be snowy, It, or humid. In these instances, air-drying garments inside are entirely acceptable.
After taking the garments from the washer, shake them out. The smoother the fabric, the simpler it is to dry.
Turn bright or dark clothing inside out to avoid fading, especially if you’re hanging it outside in the sun.
If you’re hanging your clothing outside, use a clothesline and clothespins. Make sure there is adequate ventilation, and hang the clothing in the appropriate manner for the garment.
If you want to hang your clothing inside, use a drying rack and keep them in a well-ventilated area with warm air. The garments will take too long to dry if the room is too chilly. Separate the clothing from one another to speed up drying periods, and always hang the clothes correctly for the garment type.
Fold or hang the items when they are dry. If required, iron.
Is It Ok to Air Dry Clothes?
Yes! Air drying your clothes will save you money and energy while also being healthier for the environment. Air drying can help preserve your garments from Wear and tear caused by the dryer’s heat and agitation.
How to Air Dry Clothes
When it comes to air-drying garments, I’ll go over some dos and don’ts. Following these guidelines will provide you with the greatest outcomes while air drying.
Hang Them Up
I stated how important it is to hang clothing properly, but the procedure differs depending on the item.
- Fold sheets over a clothesline and pin the ends together.
- Towels: Fold the top couple of inches of the towel over the top of the clothesline and pin the ends together.
- Shirts and t-shirts: To avoid stretching, hang them by the bottom hem.
- Hang pants and jeans by the bottom hem. Separate and pin the legs individually.
- Socks: Tie them up by the toes.
- Hang your underwear the correct way up and pin the corners.
Using these ways will save drying time while also protecting your garments.
Hang Heavier Garments
Heavy clothing and thick sweaters should not be hung. This can cause the cloth to stretch. When drying these items, always lay them flat. Place them on a clean white towel or a level drying rack.
Bleach Whites With The Sun
Hang your white garments out in the sun if you have them. This can assist in bleaching the garments and restoring their brightness and whiteness without the use of harsh chemicals.
I understand how appealing it is. However, you should not dry your clothing on the radiator. This can damage the fabric, degrade the colors, and even increase the likelihood of mold growth in the home.
Sort By Size
When hanging clothes to dry, hang the heaviest objects on the line first. Large goods should be placed on top of a drying rack if drying inside. Smaller objects can fit between larger ones, allowing you to make the most of the available space.
When it comes to indoor drying, putting the larger things on top guarantees they get the most airflow because they take longer to dry.
Check The Weather
Check the weather before hanging your clothes to dry outside. It’s pointless to hang clothes outside to dry if it’s going to rain, snow, or be extremely cold or humid. Similarly, if the pollen count is high that day, allergens will accumulate on the garments. If anyone in the family has allergies, this will be vexing.
Hang Brights and Darks In Sunlight
Because direct sunshine may bleach garments, I recommend that you store your bright and dark colors in the shade. Hide them under other clothing, or have a separate clothesline for these specific items behind a tree or in the shade.
Keep The Line Clean
Keep it clean, whether you’re needing a clothesline or a drying rack. Otherwise, you may find yourself back at square one with soiled clothes.
How Can I Make My Clothes Dry Faster?
Before air drying or tumble drying your garments, use an extra-high spin cycle.
Add a dry towel to your tumble drying cycle for the first 30 minutes. This absorbs extra water and hastens the drying process.
Toss a tennis ball into the dryer. This causes the clothing to bounce about more, lengthening the drying time.
Don’t overfill the dryer. Clothes require space to move and dry, and if you overstuff, they will be unable to do so.
Make use of a clothes wringer. These helpful gadgets extract any surplus water from your clothing, allowing them to air dry faster.
To eliminate extra moisture, roll them up in a towel before air drying.
How Can I Dry It Jeans Fast?
The hairdryer trick is great for drying jeans! If you don’t have a lot of time, perform the hairdryer tip for a few minutes to prepare them for air drying. Then, on a nice, windy day, hang them outside.
I also recommend running the jeans through a vigorous spin cycle before air-drying them.
You may also put them in the tumble dryer for 15 minutes on low heat. This should remove some of the extra moisture, allowing the air to dry faster.
How to Dry Hand Washed Clothes
Hand washing clothing is an excellent method to conserve electricity. However, the garments are frequently Itter than if they had just come out of the washing machine. If they can withstand it, run them through a vigorous spin cycle to remove extra moisture before air drying.
Otherwise, press the excess water out with a clean white towel. If the clothing is not too fragile, use a hand wringer to properly squeeze out extra water.
Twist-wringing clothes can stretch the fabric. To drain extra moisture, you may absolutely push the garment against the edge of a tub.
Is It Bad to Dry Clothes in Your Bedroom?
I recommend drying your clothing in a well-ventilated space, but avoid drying them in bedrooms or living rooms. Indoor air drying can increase moisture levels by up to 30%.
This increases the likelihood of mold developing inside. This may cause a response if you have asthma or allergies.
What Is the Best Way to Dry Clothes Indoors?
Although air-drying garments outside is the ideal option, it isn’t always practical, especially in the cold.
Here are some of your best techniques for drying clothing indoors:
Place the clothing in a you well-ventilated location to dry. Opening windows and turning on fans can be beneficial.
Larger things should be hung at the top of a drying rack, while smaller items should be hung at the bottom.
Hanging clothes on the radiator can cause damage and increase the likelihood of mold growth.
Avoid draping your clothes in your bedroom or living room.
Wash your clothing overnight or in the morning so it may air dry all day.
To dry your garments, use coat hangers. This maintains clothing in good condition while also allowing for optimal air movement through the fabric.
Invest in a dehumidifier to help with excessive moisture levels and to speed up the drying process.
How Can I Dry My Clothes Indoors Without Smelling Damp?
The clothes smell damp during the first few hours of drying. However, if the scent remains, it is due to the garments not drying quickly enough. Following all of your advice, suggestions, and assistance will help you get rid of the unpleasant It smell. However, as a precaution, the following key suggestions are reiterated:
As soon as the washing cycle is done, hang the items to dry. They’ll still smell good from the cycle. They will smell moist inside if you leave them for too long before hanging. To improve air movement, keep the windows open and the fans on. Spray scented white vinegar on the clothing as they dry to eliminate odors. When drying clothing, avoid overlapping them. This shortens the drying time.
How To Dry Clothing The Right Way Bottom Line
Follow your top suggestions to ensure your clothes are completely dry. Whether you air dry or tumble dry your clothing, following advice will help you protect them while also ensuring they are completely dry.
Our suggestions will also reduce the likelihood of mildew indoors and damp-smelling clothing. You may now have fresh, clean, and dry clothes regardless of the weather or time of year!
Need More Drying Tips?
- How To Keep Clothes From Wrinkling In The Dryer
- How To Dry Clothing The Right Way
- What Is Tumble Dry? Understanding Your Washing Label
Check out the planner!
You can also grab a copy of my cleaning planner, “The Get It Clean Cleaning Planner here on the site. It’s packed full of extremely practical tips and tricks and checklists that can help you get your house clean, and keep it clean once and for all.
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The silicone rubber sleeves better protect handpiece from contaminating.
What is Negative-pressure wound therapy
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UNI EN ISO 9712 - ASNT SNT TC 1A - NAS 410 - EN 4179
Non-destructive tests (N.D.T.) are inspections, checks and surveys carried out by means of methods that do not alter the material and do not require the destruction or removal of test samples from the concerned structure. The main feature of this kind of tests is the possibility to check the concerned parts without interfering with the tested material.
Non-destructive tests are thus used not only as a control of the finished product but also as production support, as preliminary pre-treatment tests or as controls in line downstream of a process that poses risks for the integrity of materials.
These tests have become important tools to ensure the safety and reliability of products contributing significantly to the reduction of non-compliance of the product and, ultimately, to reduce breakage during operation.
The range of NDT methods application is really extended. Basically it is possible to control everything, metallic and non metallic products, products with different shapes, with different thicknesses.
TEC Eurolab NDT Dept. is equipped with cutting edge equipment and NDT inspections are carried out by 2nd and 3rd Level technicians in all NDT Methods: Visual Inspection (VT), Dye/fluorescent penetrants (PT), Magnetic particles test (MT), Ultrasonic test (UT), Eddy Current test (ET), Radiographic test (RT), Thermographic test (IT), Extensometric test, Metallographic Replica on-site tests, Phased-Array test, On-site chemical analysis (PMI), Hardness test with portable instruments
The qualifications of our staff, range over the following standards:


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Update: The AP, Fairey and Fairey’s companies have agreed to settle their lawsuits, according to a statement from the AP. The terms of the settlement include that Fairey and AP will share the rights to make the posters and other merchandise bearing the “Hope” image and “to collaborate on a series of images that Fairey will create based on AP photographs.
Additional financial terms were reached, but were not disclosed.
The skirmish between the Associated Press and artist Shepard Fairey over his use of an AP photo of Barack Obama has always struck us as the kind of lawsuit that would settle quickly.
The facts are fairly simple, the law on “fair use” rather murky. And, frankly, neither side comes off as particularly sympathetic: An artist who stubbornly defended his right to use the AP photo; a news organization going after an artist. Rather than get into a protracted legal battle (while waging a concomitant battle in the press), we’d figure we’d have seen a settlement by now. (Click here, here and here for earlier LB posts on the dispute).
Well, nearly two years after the battle hit the courts, it looks like we finally might be moving toward a resolution.
Manhattan federal judge Alvin Hellerstein on Tuesday dismissed copyright lawsuits between Fairey and the AP in light of a “suggestion of settlement” made by the parties. At . . .


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Mary Baldwin College has applied for Accreditation – Provisional from the Accreditation Review Commission on Education for the Physician Assistant (ARC-PA). Mary Baldwin College/Murphy Deming College of Health Sciences anticipates matriculating its first class in August 2015, pending Accreditation – Provisional in March 2015. Accreditation – Provisional is an accreditation status for a new PA program that has not yet enrolled students, but at the time of its initial accreditation review, has demonstrated its preparedness to initiate a program in accordance with the accreditation Standards.
In the event the Physician Assistant Program is not granted Accreditation, all application fees, tuition or other fees paid to Mary Baldwin College/Murphy Deming College of Health Sciences will be refunded in full, and the Program will not commence. Provided Accreditation-Provisional is granted, Mary Baldwin College/Murphy Deming College of Health Sciences Physician Assistant Program anticipates accepting a class size not to exceed 45 students.


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Dr. Wang’s lab conducts basic and translational research on oncogenic protein kinases in the area of cancer biology. The main focus is on diacylglycerol (DAG)-targeted protein kinases, particularly protein kinase D (PKD) and protein kinase C (PKC) family kinases. DAG is a key second messenger generated in cells in response to the activation of receptor tyrosine kinases and G protein-coupled receptors. It acts to disseminate vital signals from the cell surface to the cell interior. PKD and PKC are primary targets of DAG that regulate many fundamental cellular processes such as cell growth, survival, apoptosis, motility, and protein trafficking. In particular, PKD is at the center of the DAG signaling network, integrating signals from both DAG and PKC. In recent years, PKD has emerged as a promising therapeutic target for several diseases including cancer and heart disease. Deregulated PKD expression and activity have been demonstrated in a variety of pathological conditions, suggesting an active contribution to disease initiation and progression.
Structure and regulation of PKD
We seek to understand both the basic structure of PKD and how different structural domains in PKD interact to regulate its activity and function. We are particularly interested in the C1 domain, the high affinity DAG binding domain shared among all DAG receptors. Our previous studies identified PKD as a high affinity receptor for DAG and defined the structure-activity requirements for the binding of the PKD C1 domain to DAG and phorbol esters. This work has provided the basis for ligand-specific regulation of PKD isoforms. Our long-term goal is to investigate the intra- and intermolecular regulatory mechanisms controlling PKD activity and assess their impact on the function of PKD in intact cells. Ultimately, we seek to solve the 3D structure of this protein.
PKD as a novel therapeutic target in cancer
Growing evidence has implicated PKD in the pathogenesis of cancer. Using prostate cancer as a model, we will determine the functional relevance and signaling mechanisms of PKD in cancer. We will elucidate the signaling pathways both upstream and downstream of PKD and identify novel PKD substrates relevant to cancer promotion. In previous studies, we have identified PKD3 as a downstream target of the oncogenic kinase PKCe. We found that PKD3 acts through a hyperactive PKCe/PKD3 pathway to modulate the activity of ERK1/2 and Akt signaling, contributing to the growth and survival of prostate cancer cells. Another active area of research in our lab is to determine the in vivo relevance of PKD signaling to cancer. We use a variety of animal models including mouse xenograft models and transgenic/knock-out mice to determine the role of PKD in prostate cancer initiation, progression, and metastasis. In addition, we also study the cross-regulation between PKD and androgen receptor signaling and its implication in prostate cancer. Our studies have now expanded to other types of solid tumors such as head and neck cancer and pancreatic cancer. In the long run, we seek to validate PKD as a therapeutic target for cancer therapy.
Development of small molecule inhibitors of PKD
In this major research endeavor, we seek to develop potent and selective small molecule inhibitors of PKD as pharmacological tools for dissecting PKD-mediated biological processes and as potential drugs for clinical application. This is an important study in the translation of PKD-targeted therapeutics into the clinic. In collaboration with our colleagues at the University of Pittsburgh Drug Discovery Institute and the Department of Chemistry, we have identified the first potent and selective small molecule PKD inhibitor, CID755673, and subsequently developed a class of unique ATP-noncompetitive inhibitors based on this parental compound. These inhibitors are cell-active and exhibit nanomolar potencies, with high specificity for PKD. Future studies are focused on further developing this series of inhibitors for in vivo and clinical application, and continuing our efforts in new drug discovery.
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