RALEIGH No longer is there anything odd-numbered about Alexander Centrals run of four NCHSAA 4A state softball titles the past six seasons.
The Cougars capped an unbeaten record at 35-0 with an 18-7 win over Fayetteville Cape Fear to complete a two-game sweep of the best-of-3 series that concluded Saturday at the Walnut Creek Softball Complex.
This years title was Centrals second straight after being limited to every-other-year championships in 2009, 2011 and 2013.
Something else out of the ordinary for the 2014 win: Senior Bailey Sherrill earned the MVP award over her more highly publicized sister. Junior Vada Sherrill was the North Carolina Gatorade Player of the Year.
In Fridays 4-3 win, Bailey was 2 of 2 with two runs scored. In Saturdays contest, still a one-run affair through five innings, she kept the Cougars on top with one run scored and two RBIs in her first two at-bats. She finished the game 2 of 4 with two runs scored and three RBIs.
Id rather have her win the award than me, Vada said. She earns everything she does in every way.
Bailey was diagnosed with leukemia when she was 3 years old, but she has been cancer-free since she was 6.
Shes a fighter, Vada said. Shes truly a hero to me.
Bailey was flabbergasted by the award and attention showered on her by teammates, family and fans and took a few moments to be able to express herself.
Whew! Im usually in the background, she said. But when the moment comes, you try to do your best. All these girls are my sisters.
The decision was Centrals 24th double-digit victory of the year, but the Cougars responded to rare pressure on them. They trailed 3-2 after two innings and led only 6-5 after the third until Cape Fear (26-3) imploded; Central scored 5 in the sixth and 7 in the seventh.
It shows what were about, Vada said. When we step on the field, our true colors come out.
The Charlotte Observer welcomes your comments on news of the day. The more voices engaged in conversation, the better for us all, but do keep it civil. Please refrain from profanity, obscenity, spam, name-calling or attacking others for their views.
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The Dorian Mode: Essential Guitar Scales
Today’s lesson is a quick style file focus on the Dorian mode. It includes all five shapes of the scale, a neck diagram, triad and arpeggio shapes, some useful progressions and three essential licks!
One octave of the Dorian mode can be played as follows:
Formula 1 2 b3 4 5 6 b7
Parent Scale: Major
In a sentence: Cool, funky and relaxed.
So What – Miles Davis
Billy Jean – Michael Jackson
Tender Surrender – Steve Vai (with a few key changes to related modes)
The Dorian mode creates a laid back, chilled out vibe and as such it is commonly used to solo in downbeat rock, funk and jazz. It is heard in the A sections of Herbie Hancock’s Maiden Voyage, Eleanor Rigby by The Beatles and Paradise by Coldplay.
It is often used in modern rock and blues (such as the middle section of Stairway to Heaven by Led Zeppelin) and is one of the most commonly used minor modes.
C Dorian Scale Shapes
C Dorian Triad and Arpeggio Shapes
Typical Chord Progressions
Backing Track Dorian 1:
Backing Track Dorian 2:
Backing Track Dorian 3:
Dorian Scale Lick 1:
Dorian Scale Lick 2:
Dorian Scale Lick 3:
Obviously there is loads more we can look at in the Dorian mode. Fro more ideas, check out my book Guitar Scales in Context, available on Amazon now.
In the next lesson, we will be looking at an incredible useful sound: The Mixolydian Mode

domain: artistic


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Turkey’s attempts to stabilize its embattled financial markets had borne some fruit this week, sparking a brief relief rally in the lira, but investors are still looking for ways to hedge against any new shocks.
That negative sentiment toward Turkey was on full view again on Friday, when the lira sank more around 5% against the dollar after the U.S. on Thursday threatened new penalties against the country over its detention of a U.S. pastor.
Friday’s drop brought to an end three straight days of gains for the lira — which is still up 5% this week against the dollar — after it hit a record low on Monday. The rally came after Qatar announced a $15 billion support package and Turkey’s banking regulator moved to limit the amount of the local currency banks can swap for foreign currencies with counterparts.
Investors say the intervention made it more expensive to bet on declines in the lira and helped provide some support for the currency. But analysts also warned that the measures haven’t addressed concerns over the economic policies of Turkey’s President Recep Tayyip Erdogan, Turkey’s runaway inflation, its souring relationship with the U.S. and its large foreign-currency debt that is due to mature over the next 12 months.
“I would compare it to taking painkillers when you have cancer. It will reduce the pain short term, but won’t cure the underlying illness and problems of the Turkish economy,” said Carsten Hesse, an economist at Berenberg.
Indeed, IMF data show that Turkey’s pot of foreign-exchange reserves is ill-equipped to service its debt. Turkey’s official foreign-exchange reserves stand at around $100 billion, but that figure could be inflated because of the large amounts of foreign-currency reserves and gold that Turkish banks are allowed to place at the central bank to comply with their reserve requirements.
The uncertainty over the long-term health of the Turkish economy has seen investors scramble for protection across a range of markets — not just selling the lira.
The amount of Turkish government dollar bonds on loan — a proxy for short demand — has grown to $1.4 billion from $350 million at the start of the year, according to IHS Markit. In the equity market, the short position in the iShares MSCI Turkey ETF hit a year-to-date high of 4.3 million shares this week, nearly double the short position at the start of the year.
Volumes have also been high in the credit-default swap market, according to Gavan Nolan, director at IHS Markit, where investors can buy insurance against a Turkish sovereign default.
Paul McNamara, a fund manager at GAM, said it is important to be discerning when choosing hedges. “You get what you pay for,” he said. “At this point protection on most of the risks [is] expensive.”
In a conference call with international investors on Thursday, Turkey’s Finance Minister Berat Albayrak acknowledged the difficult conditions but vowed that his country will come out stronger, according to two participants in the call.
“With their backs against the wall, they had to do something and after this call investors might give him the benefit of the doubt,” said Richard Segal, emerging-market analyst at Manulife Asset Management, who was on the call. “But there is still scope for things to go wrong.”
The lira is down nearly 40% against the U.S. dollar this year. That selloff accelerated sharply last week after the U.S. imposed sanctions on Turkey over the detention of U.S. pastor Andrew Brunson. Tensions between the two countries escalated further as Washington and Ankara levied trade tariffs on each others’ goods.
On Friday, a Turkish court rejected Mr. Brunson’s latest appeal against his house arrest and travel ban.
Other emerging-market currencies were also under pressure Friday. The Brazilian real, Mexican peso and Russian ruble all fell 0.8% against the dollar in recent trade.

domain: finance


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contact tN got their new logo design by running a design contest:
Design a Logo for a Tabletop Board Game Publisher
Check out contact tN's Logo design contest…
Games & Recreational
Board game & card game publisher. That is, traditional table top games and not video games.
Logo types to explore
Please don't let the included examples box you in. I don't have anything really in mind right now. When I think of "entropy" I think of a destructive force or a negative energy. The "restless" aspect gives it a motive. I am okay with the logo being serious and literal or comical and light-hearted.
299 US$ Bronze package
Every design category has flexible pricing for all budgets. Logo design starts at €269.
Full copyright with production-ready files for digital and/or print.
It all began with a design brief.
A quick, interactive guide helped them understand their design style and captured exactly what they needed in their logo design.
Designers across the globe delivered design magic.
contact tN collaborated with designers to refine their ideas
When design entries come in, you can rate them so designers know what you’re looking for in your logo design.
99designs has great collaboration tools so you can pinpoint and capture your ideas
And then… they selected 2 winners!
I love working with TamaCide and will continue to work with him as much as possible! He is creative, quick, professional, and does high quality work.
Along the way, they met lots of talented designers…
We think contests are a super fun way to get design.
Recently completed contests:
I'm an independent mobile app and game developer. I target a wide audience across the world. If you are curious about o
I'm building a sportfish boat, looking for a custom logo for the boats name. It will be on a teak transom.
We sell fuse bead kits (link to product: https://www.amazon.com/dp/B078FG9ZRX) and will grow into other arts and craft a
We are a soon to be toy review blog, YouTube, Instagram that also has a line of branded toy products. Logo would be on Y
We rent bounce houses, slides, carnival games. Our main audience is residential. We want it fun and playful but still mo
We sell RV (trailer and camper) roof coating to consumers who are tired of dealing with a leaky RV roof. This DIY option


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24 August – 2 September 2018 -
The countdown to the region’s favourite annual celebration is on!
Cairns Festival is set to showcase the vibrant, tropical lifestyle and creative spirit of Far North Queensland with a multi-dimensional program of family-friendly events and activities spanning music, art, craft, culture, dance, theatre, comedy and markets.
This year’s event runs over 10 action-packed days.
Note: Information on listed products and services are provided by the operator and were correct at the time of publishing. Rates are indicative based on the minimum and maximum available prices of products and services. Please visit the operator’s website for further information. All prices quoted are in Australian dollars (AUD).

domain: entertainment


Sultry Sophia Red Top
What a fabulous basic to have! This is a solid red knit top with slight puff sleeves and a beautiful collar to highlight your cleavage. Wear this top with anything and get ready for all the attention! 80% polyester, 16% rayon and 4% spandex. Super stretchy, machine wash cold, hang dry and Made in the USA.


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Gulf coast island gateway
As the largest province in South Thailand, Surat Thani stretches from the brilliant white-sand shores of popular Gulf islands to forest-shrouded karsts found within 20 kilometres of the Andaman Sea. The provincial capital, commonly known as Surat, is a busy transport hub where locals unload fresh seafood as travellers hunt for ferry tickets.
Browse hotels in Surat Thani on Agoda
Provided by Travelfish partner Agoda.
Named after a city in India, Surat Thani translates as “City of Good People”, though you might feel otherwise after dealing with some of the aggressive touts and shifty travel agents. Most travellers who pass through are heading straight to/from the very popular islands of Ko Samui, Ko Pha Ngan and Ko Tao. Few spend more than a night in Surat, which many see as nothing more than a place to catch a boat. We think the scenic riverfront, great food and worthwhile day trips make it a destination in its own right.
The old Chinese-influenced Ban Don part of town features century-old Sino-European architecture that — with a bit of restoration — could be as picturesque as some of the heritage shophouses found in old Phuket town. The nearby Tapi riverfront, with its laidback night market and longtail boat pier, reminds us of Krabi’s better-known waterfront area. A boat trip into the Tapi’s tributaries will take you past old stilted houses, towering coconut trees and dense feathered palms that turn waterways ... Travelfish members only (Full text is around 1,200 words.)
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62 other destinations in Southern Thailand

domain: geography


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Thursday, January 22, 2009
Social Security and Medicare hide perverse incentives
Gary Andres (Dutko Worldwide) and James C. Capretta (EPPC, Ethics and Public Policy Center) have an op-ed on p A25 of the Jan. 22 Washington Times, “Needed: more elderly workers: Perverse social security, Medicare incentives must go,” link here.
For one thing, I didn’t know that the Annual Earnings Test used to be applied to age 69 until the 1995 Contract with America (Newt Gingrich’s baby) knocked it back to full retirement age.
There is also a disincentive built into counting only the top 35 years for total benefits (instead of all work). Workers and their employers continue to pay full FICA taxes if working past retirement age. And according to Reagan’s 1982 budget reforms, employers have to take care of the health care costs ahead of Medicare, if they offer insurance.
Hence, with these policy choices, employers have perverse incentives to push out retirees early, and employees have perverse incentives to take buyouts. Maybe a lot of us in our early or mid 60s would still be working at full income were it not for these perverse policy choices, say the authors. In my case, that’s believable. We would be paying a lot more income tax than what is saved in the short run by these rules.
Add another trick that the authors didn’t mention, the social security offset in pension calculations.
This piece didn’t go into the “morality’ of means testing, because conservative columnists generally don’t like to argue for playing Robin Hood (even when there are no “rich” to start with). But there may be some relatively painless fixes to Social Security and Medicare for Mr. Obama to consider after all.

domain: politics


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This is a book I wrote a few years ago, I've changed it to fit in with the artwork on Storybird. Rosie goes on to have a series of adventures with her friend. My girls love it-I hope you do too!
Before braces: Makayla Perry is the most popular girl in school and she thinks it will remain that way no matter what. After braces: nothing is ever the same. A story about learning to love yourself.
A memoir about middle school dances.
What you can do only with a few words on a page.
Read the June Challenge entries
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or sign in with email below

domain: library


text:
Terms and Conditions
USE OF THE GEORGINI SITE
As a condition of creating an account with Georgini, you agree to receive communications via email from Georgini Pty Ltd.
This warranty is given by:
Georgini Pty Ltd
Shop 2022, Pitt St Mall, Westfield Sydney, NSW, 2000
Tel: +61 2 9318 2444
The benefits given by this warranty are in addition to any other rights and remedies you may have under a law in relation to the goods to which the warranty relates. Our goods come with guarantees that cannot be excluded under the Australian Consumer Law.
You are entitled to a replacement or refund for a major failure and for compensation for any other reasonably foreseeable loss or damage. You are also entitled to have the goods repaired or replaced if the goods fail to be of acceptable quality and the failure does not amount to a major failure.
This warranty only applies to Georgini products purchased from an authorised Georgini retailer. You must provide proof of purchase when you make a claim under this warranty. This warranty applies to defects in materials or manufacturing of Georgini products that appear within one year of the original purchase date. Georgini will, within a reasonable period, repair or replace any defective products with a product of the same value at the time you make your claim. You will not have to pay for the replacement product or the labour cost of doing the repair but you will have to pay for transport of the products and the insurance of the products during transit. If you want to make a claim under your warranty please return
the defective product to the retailer from whom you purchased the product with proof of purchase. If you send the product to the retailer by post please send it by registered mail and insure it for damage, loss or theft occurring during transport. If you are entitled to make a claim under this warranty and you have incurred authorised labour costs directly related to the repair or replacement of the defective product, please send your receipt as proof of payment of these costs to Georgini Pty Ltd at the below address.This warranty does not cover damage to products that is caused by accidents, misuse, abuse or wear and tear. Georgini is not liable for any loss or damage to products whilst in transit.
ADDRESS FOR WARRANTY RETURNS
P.O. BOX 2622, Taren Point, NSW 2229

domain: law


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CLEVELAND (92.3 The Fan) – Browns receiver Josh Gordon hopes to apply for reinstatement again in late September following another stint in rehab.
Gordon checked himself into rehab 2 months ago in cooperation with the NFL according to Jason Cole of Bleacher Report.
It marks the fourth known time that Gordon has sought treatment for substance abuse issues.
NFL commissioner Roger Goodell confirmed that Gordon had sought treatment again during a question and answer forum with Browns fans on Aug. 17 but that no decision on his reinstatement was pending anytime soon.
“He has entered into the program,” Goodell said. “He has obliviously confidentiality and privacy issues that we always respect but when a decision is made on his reinstatement one way or the other, we make that clear to the clubs, and obviously publicly.
“That’s not under active consideration, to my knowledge, at least [it] hasn’t gotten to my desk yet.”
Gordon’s most recent application for reinstatement was denied in March with another opportunity to reapply set for mid to late September.
Gordon, who has missed 43 of the last 48 regular season games due to suspension, hasn’t played a full season for the Browns since his 2012 rookie season due to multiple violations of the league’s drug policies.
Gordon was set to rejoin the Browns last year following a 1-year ban and he spent training camp with the team before serving an additional 4-game suspension at the outset of the 2016 season. As he was set to be reinstated in October he checked himself into rehab amid rumors of another failed test.
The current Browns regime has wavered back and forth in their support of Gordon.
Last fall head coach Hue Jackson used the phrase “time to move on” when Gordon left the team and had his indefinite suspension reinstated. This spring executive vice president of football operations Sashi Brown softened the team’s stance and last week was supportive of Gordon’s rehabilitation when following up the commissioners comments with his own.
“I think the most important thing for Josh is for Josh as a young man to get himself to a point where he gets past some of the issues that have prevented him from being able to participate,” Brown said last week, “and once we get to that stage, those questions will be answered in terms of his return to the field. But we care first and foremost in the league about the young man and that’s where the focus will remain until we get to that point.”

domain: news


Even with its big upfront costs, more and more businesses and municipalities are seeing the economic and sustainable virtues of going geothermal. Could the system currently being installed in the Marketplace Building signal a shift in downtown building practices?
"The geothermal system at the Marketplace Building starts underground in a lot north of Argiero's Restaurant, running under the brick pavement of Detroit Street to reach the building.
Aspects like crossing a public right-of-way with the underground pipes, liability and ongoing maintenance of the pipes under roadways concerned city staff as they researched and finalized the agreements, Harshe said.
The Downtown Development Authority, which funded part of the effort through its Energy Program, also played a role.
“I’m intrigued about its potential to make downtown even more of a sustainable center,” said Susan Pollay, executive director of the DDA."
Read the rest of the story here


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The antigenic variability of influenza viruses has always made influenza vaccine development challenging. The punctuated nature of antigenic drift of influenza virus suggests that a relatively small number of genetic changes or combinations of genetic changes may drive changes in antigenic phenotype. The present study aimed to identify antigenicity-associated sites in the hemagglutinin protein of A/H1N1 seasonal influenza virus using computational approaches. Random Forest Regression (RFR) and Support Vector Regression based on Recursive Feature Elimination (SVR-RFE) were applied to H1N1 seasonal influenza viruses and used to analyze the associations between amino acid changes in the HA1 polypeptide and antigenic variation based on hemagglutination-inhibition (HI) assay data. Twenty-three and twenty antigenicity-associated sites were identified by RFR and SVR-RFE, respectively, by considering the joint effects of amino acid residues on antigenic drift. Our proposed approaches were further validated with the H3N2 dataset. The prediction models developed in this study can quantitatively predict antigenic differences with high prediction accuracy based only on HA1 sequences. Application of the study results can increase understanding of H1N1 seasonal influenza virus antigenic evolution and accelerate the selection of vaccine strains.
Citation: Ren X, Li Y, Liu X, Shen X, Gao W, Li J (2015) Computational Identification of Antigenicity-Associated Sites in the Hemagglutinin Protein of A/H1N1 Seasonal Influenza Virus. PLoS ONE 10(5): e0126742. doi:10.1371/journal.pone.0126742
Academic Editor: Zhiping Ye, US Food and Drug Administration, UNITED STATES
Received: October 16, 2014; Accepted: April 7, 2015; Published: May 15, 2015
Copyright: © 2015 Ren et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Data Availability: All relevant data are available in the paper and its Supporting Information files.
Funding: This study was supported by the National Natural Science Foundation of China (No.81102205) to XR and by the Fundamental Research Funds for the Central Universities (No.lzujbky-2012-155) to XR. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests: The authors have declared that no competing interests exist.
Influenza is an infectious disease caused by the influenza virus. Seasonal influenza causes approximately 250,000 to 500,000 deaths per year worldwide . Influenza A/H1N1, A/H3N2, and B viruses are currently the main circulating subtypes of seasonal influenza that are included in each year’s influenza vaccine. After the 1918 Spanish influenza pandemic, the A/H1N1 influenza virus caused a number of outbreaks and epidemics until its disappearance from the human population in 1957 . The H1N1 virus reappeared in the 1977 Russian influenza epidemic and began to exhibit seasonal circulation worldwide among the human population . Vaccination is the most effective way to prevent influenza infection. The primary components of influenza vaccines have to be updated annually due to antigenic drift of influenza viruses. The influenza virus surface glycoprotein hemagglutinin (HA) is the primary target of neutralizing antibodies. The HA protein consists of two polypeptides, HA1 and HA2. The HA1 polypeptide plays a much more important role than HA2 in natural selection . The gradual accumulation of amino acid substitutions in HA1 results in antigenic drift as antigenic properties change with time . The seasonal influenza vaccine cannot offer effective protection against antigenically mismatched circulating strains. Antigenic differences between influenza strains are routinely measured by hemagglutination-inhibition (HI) assays that assess the ability of reference antiserum to prevent agglutination of red blood cells by influenza virus particles.
Smith et al. created an antigenic evolution map of influenza A/H3N2 virus using HI assay data and showed that antigenic evolution was more punctuated than genetic evolution, with a single amino acid change sometimes having a disproportionately large antigenic effect . Li et al. also demonstrated that single HA mutations that alter both antigenicity and receptor binding avidity influenced influenza virus antigenic clustering . Therefore, there are compelling reasons to identify antigenicity-associated sites in HA1. In turn, identification of these sites may offer insight into the antigenic drift of influenza viruses and accelerate the selection of vaccine strains. Sun et al. suggested that antigenicity-associated sites were not necessarily the same among subtypes of influenza A viruses because of different antibody binding sites . For H3N2 seasonal influenza viruses, various studies have used statistical models to identify critical antigenic amino acid positions based on HI assays and HA1 sequences [9–12]. However, only a few studies have explored amino acid sites that drive the antigenic drift of H1N1 seasonal influenza virus using HI assay data. Recently, Huang et al. identified 41 H1N1 HA natural epitope residues based on 1572 HA sequences and 197 pairs of HA sequences with HI assays. Likelihood ratios used to correlate a single mutation at the amino acid position with an antigenic variant were utilized to establish the antigenic variant score . However, recent studies have revealed that amino acid interactions play a key role in the process that antigenic site mutations modulate receptor-binding site (RBS) properties; hence, it is necessary to consider the joint effects of amino acid residues on antigenic drift when inferring the relationships between antigenic variants and amino acid changes .
In the present study, two widely used multivariate feature selection methods, Random Forest Regression (RFR) and Support Vector Regression based on Recursive Feature Elimination (SVR-RFE), were used to analyze the associations between amino acid changes in the HA1 polypeptide and antigenic variation based on HI assay data and HA1 sequences. These models identified the best combinations of amino acid sites that could quantitatively predict antigenic differences between different strains of H1N1 seasonal influenza with high prediction accuracy using HA1 sequences. Antigenic cartography methods were used to quantify and visualize the antigenic evolution of H1N1 seasonal influenza viruses from 1977 to 2008, and antigenic cluster transitions were found to be associated with important amino acid substitutions in the HA1 domain of HA. Finally, our computational approaches were validated with the H3N2 dataset to assess the performance when applied to H3N2 influenza viruses. We believe that the identification of antigenicity-associated sites will be helpful in better understanding the antigenic evolution of H1N1 seasonal influenza virus and facilitating influenza vaccine strain selection.
Materials and Methods
HI assay data
The HI assay data on the H1N1 seasonal influenza viruses used in this study were collected from related articles and documents published by the US Centers for Disease Control and Prevention and other collaborating centers of the World Health Organization (WHO) [15–22]. Under the premise of without changing the ratios between homologous and heterologous antibody titers, which were used to calculate antigenic distances, homologous antibody titers were standardized to equal 1280. The combined HI table was shown in S1 Table. The HI assay dataset contained 154 pairwise comparisons of 37 H1N1 viruses isolated from 1977 to 2008. The antigenic difference between two viruses was measured using the Archetti-Horsfall antigenic distance metric, which could control for receptor binding avidity variation between viral strains [7, 23]. The antigenic distance metric between strains A and B was defined using the following formula: (1) HXY = HI titer of virus strain X (antigen) relative to antiserum raised against virus strain Y. HAA and HBB = homologous titers of two strains. HBA and HAB = heterologous titers against each other.
Antigenic distances greater than 2 were usually treated as antigenic variants .
HA sequence data
Thirty-seven HA1 amino acid sequences of H1N1 seasonal influenza viruses isolated from 1977 to 2008 were downloaded from the National Center for Biotechnology Information Influenza Virus Resource (Table 1) (http://www.ncbi.nlm.nih.gov/genomes/FLU/FLU.html) . All HA1 sequences were aligned with ClustalW and trimmed to the same length (327 amino acid residues) . Each pairwise amino acid sequence alignment was converted to a 1 x 327 vector. For a specific HA1 sequence position, the value was denoted as 1 if the residue types of the two HA1 sequences were different (mutation); otherwise, its value was denoted as 0 (no mutation). One hundred and fifty-four pairwise amino acid sequence alignments were linked with pairwise antigenic distances for further analysis.
The previously published A/H3N2 dataset by Smith et al. was used to validate the biological relevance of the results of our approaches . The validation dataset consisted of 271 pairwise antigenic distances among 52 viruses isolated between 1968 and 2003. The HI table was shown in S2 Table.
Random forest regression
Random forests is a widely used machine learning algorithm that has been applied to classification and regression problems. It was introduced by Breiman in 2001 . RFR is an ensemble of regression trees in which each tree is constructed on a bootstrap sample that is a subset of the original sample. At each splitting node of a tree, the candidate set of variables is a random subset of the explanatory variables. To reduce bias, no pruning step is performed; hence, all trees of the forest are maximal trees. The overall prediction of the forest is the average of predictions from all individual trees. For each tree, approximately one third of the data that are not included in the bootstrap sample are termed the “out-of-bag” (OOB) sample. The OOB sample is used as a testing set for that tree to estimate the prediction performance and then to evaluate variable importance. There are three parameters that need to be determined for RFR: ntree—the number of trees in the forest; nodesize—the minimum size of the terminal nodes; and mtry—the number of variables randomly sampled as candidates at each split. In this study, the parameters ntree and nodesize were set to their default values (ntree = 500 and nodesize = 5 for regression). The most important parameter (mtry) was tuned to achieve optimal predictive performance and increase the statistical power of the algorithm to detect true antigenicity-associated sites. Cases of mtry equaling p (equivalent to bagging), 2/3p, p/2, p/3, p/4, and sqrt(p) were considered, where p was the number of variables in the data set. The permutation-based “mean of squared residuals (MSE) reduction” was used as the random forest importance criterion to give a ranking of variable importance, and the variables with high ranks were considered as potentially associated with antigenicity. In this study, a variable reduction wrapper algorithm was employed to find the best putative combinations of amino acid sites . This measure of importance was used to rank the variables from most to least important, and the RFR model’s performance could be monitored as more and more of the least important variables were iteratively removed. A 5-fold cross-validation (CV) procedure was used to evaluate the predictive performance of the RFR model. In the variable selection process, variable importance was not recalculated at each step because Svetnik et al. 2004 reported that severe overfitting results from recalculating variable importance. The CV test set MSE was used to assess the predictive performance of the RFR model. The smaller the MSE, the better the performance will be. The final RFR model was chosen by using the corrected Akaike information criterion (AICc)  to prevent overfitting. The RFR algorithm and the nested cross-validation procedure were implemented by the randomForest R package .
Support vector regression based on recursive feature elimination
A support vector machine is a supervised data mining method based on statistical learning theory used for classification and regression. The basic idea of support vector regression was formulated by Vapnik et al. in 1995 . Instead of minimizing the observed training error in the traditional regression procedure, support vector regression attempts to minimize the generalized error bound to achieve performance in which the generalization error bound is the combination of the training error and a regularization term that controls the complexity of the hypothesis space . SVM-RFE is a popular embedded feature selection method. It was first proposed by Guyon et al. in 2002 to perform gene selection for binary classification problems . SVM-RFE uses weight magnitude as the ranking criterion and generates a ranking of features using the backward feature elimination procedure, which starts with all the features and then recursively removes one or more of the least important features at a time. In this study, the ε-SVR-RFE algorithm was used to select a subset of amino acid sites that could contribute the most to the antigenic variation of H1N1 seasonal influenza virus as an alternative machine learning method to the RFR model. The 5-fold cross-validated MSE was adopted to evaluate the prediction performance of SVR models as more and more of the least important amino acid sites were recursively removed. The SVR model with the smallest AICc value was considered as the final selected model. The parameter ε and kernel function in SVR-RFE were set to 0.01 and radial basis function (RBF) kernel, respectively. The cost parameter C and parameter γ of the RBF kernel were optimized by extensive grid search. The search was conducted in the following ranges: C − 2–8 to 28 with step size 0.1; γ − 2–5 to 25 with step size 0.1. A 5-fold cross-validation was used in our experiments to determine optimum parameters. The SVR algorithm was implemented by the Matlab version of LibSVM provided by Chang and Lin . The parameter optimization function was implemented using the Matlab toolbox Libsvm-FarutoUltimate3.1 provided by Li . SVR-RFE was written in Matlab.
The quantitative analyses of the antigenic properties of H1N1 seasonal influenza viruses collected from 1977 to 2008 were performed using antigenic cartography methods as described previously by Smith et al. for human H3N2 viruses . The HI assay data were used to construct two-dimensional (2D) antigenic maps in which the distance between points represents the antigenic distance as measured by a HI assay. One unit of antigenic distance on the antigenic map corresponds to a two-fold difference in the serological assay. The web-based software for Antigenic Cartography is available at http://www.antigenic-cartography.org/.
Amino acid changes were identified in 77 positions among the 154 pairwise comparisons of H1N1 HA1 sequences by excluding 250 positions that had no mutations (S3 Table). The amino acid positions that underwent the same change (correlation coefficient = 1) were noted as one variable. These 77 positions were classified into 60 variables based on their collinearity. Among the 154 pairwise comparisons, 83 (54%) had an antigenic distance ≥ 2 (i.e., antigenic variant), and 71 (46%) had an antigenic distance < 2 (i.e., similar antigenicity). The H3N2 validation dataset was treated in the same way. Sixty-eight variables that were within positions 109 to 301 of the HA1 region according to Koel et al. were obtained .
Antigenicity-associated sites identified using the RFR algorithm
RFR was used to quantitatively correlate amino acid changes in the HA1 region with antigenic distances and to identify the best combinations of amino acid sites that contributed to antigenic drift of H1N1 seasonal influenza viruses. The CV test set MSE curve based on the variation of the number of variables selected was plotted for different choices of mtry (Fig 1). The plot showed that mtry, p/4, performed the best, but the other choices were nearly as robust. The results suggested that the RFR model with 18 variables (mtry = p/4) achieved the smallest AICc value of 0.8115. The predictive proportion of variance explained by the final RFR model was 0.8353, suggesting that the model achieved a good predictive performance. In Table 2, the 18 variables ranked in order of importance for the final RFR model were reported. Twenty-three amino acid positions were identified as responsible for the antigenic variation of H1N1 seasonal influenza viruses.
Antigenicity-associated sites identified using the SVR-RFE
The SVR-RFE algorithm was performed to find the subset of amino acid residues that contributed the most to antigenic variation of H1N1 seasonal influenza virus. Fig 2 shows the cross-validation MSE against the number of variables used at each step of removing the least important variable. The minimum AICc value of 0.5826 was obtained at the 17-variable level by the SVR model (RBF kernel with parameters C and γ optimized to 4.5948 and 0.1015, respectively). The predictive proportion of variance explained rose up to 0.8610, which was 0.0257 higher than the RFR model. The final variable subset selected by the SVR-RFE algorithm is listed in Table 3 in order of variable importance. Twenty sites were identified as the best combinations of amino acid sites that could drive the antigenic drift of H1N1 seasonal influenza viruses.
Antigenic map of human H1N1 seasonal influenza viruses from 1977 to 2008
Antigenic cartography methods were used to map the antigenic evolution of human H1N1 seasonal influenza viruses from 1977 to 2008 (Fig 3). The antigenic evolution of human H1N1 seasonal influenza viruses was significantly slower than the antigenic evolution of human H3N2 viruses when compared with the map published by Smith et al. The antigenic evolution of H1N1 seasonal influenza viruses appeared to be punctuated rather than gradual. Two large jumps were observed in the antigenic phenotype from the ‘80–83’ strains to the ‘86–98’ strains and from the ‘86–98’ strains to the ‘99–08’ strains, and one small jump was observed from the ‘77–78’ strains to the ‘80–83’ strains. Fig 3 summarizes the cluster-transition amino acid substitutions that are most likely responsible for the antigenic differences between antigenic clusters.
The relative positions of strains (green circles) and antisera (uncolored squares) are adjusted such that the distances between strains and antisera on the map represent the corresponding HI measurements with the least error. One unit (grid) corresponds to a two-fold dilution of antiserum in the HI assay. The cluster-transition amino acid substitutions are shown in red.
Model Validation with the H3N2 dataset
Our proposed RFR and SVR-RFE approaches identified 12 and 18 antigenicity-associated sites of H3N2 influenza viruses, respectively. The importance of each variable was assessed. The variables ranked in order of importance for the RFR model and the SVR-RFE model were reported in Tables 4 and 5, respectively. The amino acid substitutions at seven positions (positions 145, 155, 156, 158, 159, 189, and 193), which were responsible for A/H3N2 antigenic cluster transitions over the 35-year period, had been experimentally validated by Koel et al.. The top ten ranked variables recognized by the RFR model included the seven experimentally validated sites, while there were six experimentally validated sites within the top ten ranked variables identified by the SVR-RFE approach. Only one experimentally validated site, position 156, was not recognized by the SVR-RFE algorithm. Both of positions 133 and 135 that had been experimentally validated as the accessory substitutions by Koel et al were also respectively identified by both our approaches. Then the experimentally validated seven positions were used to construct the RFR and SVR model. The predictive proportions of variation explained by the 7-features RFR and 7-features SVR model were, respectively, 0.8447 and 0.8496. The high rankings of experimentally validated positions in both subsets and their significant contribution to explaining variation confirmed the effectiveness of our proposed approaches in capturing important antigenicity-associated sites and predicting antigenic changes.
The WHO annually recommends an influenza vaccine composition for the coming influenza season. Antigenic characterization based on the HI assay, which is labor-intensive and time-consuming, is the primary procedure for influenza vaccine strain selection. It is of considerable importance to detect new antigenic changes occurring in HA protein when updating vaccine compositions. The punctuated nature of antigenic evolution of influenza virus suggests that a relatively small number of genetic changes or combinations of genetic changes may drive changes in antigenic phenotype .
In this study, RFR and SVR-RFE were used to identify amino acid sites associated with HA antigenicity of H1N1 seasonal influenza viruses on the basis of HI assay data and HA1 sequences. The methods used in the study are different from those of previous studies because the algorithms consider the joint effects of amino acid residues on antigenic drift when deriving antigenicity-associated sites. The results showed that CV test set MSE curves decreased sharply at first and then increased slowly with respect to the number of variables used. This trend might be attributed to the combined effects of amino acid substitutions .
The RFR and SVR-RFE algorithms identified 23 and 20 antigenicity-associated sites, respectively. Interestingly, thirteen amino acid residues overlapped between these two amino acid subsets. The first four ranked variables recognized by these two approaches contained the same six amino acid positions (43, 54, 127, 130, 141 and 193). With the RFR and SVR-RFE approaches, 2 and 5 new antigenicity-associated residues were identified, respectively, that were not covered by the natural epitope residues proposed by Huang et al. (Table 6). From the antigenic map of human H1N1 seasonal influenza viruses from 1977 to 2008, 15 amino acid positions were found that were likely to contribute to the antigenic difference between clusters. Surprisingly, the 23 and 20 antigenicity-associated sites cover 93.33% (14/15) and 73% (11/15) of cluster-differentiating mutations, respectively. The high ratio overlap reveals that the models used in this study are reliable. However, only 7 of these 15 cluster-difference substitutions overlapped with the five antigenic epitope regions (Sa, Sb, Ca1, Ca2, and Cb) previously described by Brownlee and Fodor . The low consistency reflects the different recognition mechanisms of antigenic epitopes between natural selection at the population level and neutralizing monoclonal antibodies (MAbs) in the laboratory. There were also limited antigenic differences between the ‘99–06’ strains and the ‘06–08’ strains, which might be due to a single amino acid substitution at position 141 [35, 38, 39, 40].
The H3N2 dataset was used to further validate the biological relevance of the results of our approaches. The RFR approach has been shown to be more effective in identifying the experimentally validated sites than the SVR-RFE algorithm, but the SVR model demonstrated better predictive performance compared to the RFR model. The final models developed in this study can perform quantitative prediction of antigenic differences between different strains of H1N1 based only on HA1 sequences and serve as an initial screening tool for antigenic variants before the labor-intensive and time-consuming HAI assay.
In conclusion, the proposed RFR and SVR-RFE approaches, which consider the joint effects of amino acid residues on antigenic drift, identified 23 and 20 antigenicity-associated sites of HA1 of H1N1 seasonal influenza viruses, respectively. The results obtained in this study can aid in better understanding of the antigenic evolution of H1N1 seasonal influenza viruses and accelerate the selection of vaccine strains.
S1 Table. The combined H1N1 HI table.
S2 Table. The H3N2 HI table.
S3 Table. Amino acid changes in HA1 of H1N1 seasonal influenza viruses from 1977 to 2008.
Conceived and designed the experiments: XR. Analyzed the data: XR YL. Contributed reagents/materials/analysis tools: JL XL XS WG. Wrote the paper: XR YL.
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domain: literature


text:
Summer Camp is officially in session!
Thursday, June 16, 2022 by Mary O'Connor | piano maestro
Take a bow, Alon Kaplan, for creating the first fun Summer Camp song, Disney hit "We Don't Talk About Bruno"
Available in three versions, it can be found in the new 'Summer Camp' category in the Library or tap the button on the main menu.
Tune in each week to see which other free songs will be released in Summer Camp to keep your students sharp. And remember, every 3-star performance gives your students the chance to win an Amazon Gift Card. Enjoy!


Dec 10, 2011, 4:05 PM EDT
Athletics general manager Billy Beane indicated earlier this week that he’d like to go younger with the DH spot next season, which means that Hideki Matsui will almost certainly be playing elsewhere next season. His search for a job may lead him to an interesting place: the National League.
Jon Weisman of Dodger Thoughts was told by Tony Jackson of ESPN Los Angeles via email that Matsui is among at least three names the Dodgers are considering as a left-handed bat off the bench.
Matsui, 37, has spent all nine of his MLB seasons in the American League. He is coming off the worst season of his career, though, hitting just .251/.321/.375 with 12 homers and a .696 OPS in 141 games.
There are plenty of one-dimensional aging DH-types available this winter, including Vladimir Guerrero, Johnny Damon and, yes, even Manny Ramirez, so with Matsui’s skills in decline, a bench job might be the best he can do. We probably wouldn’t see him in the outfield much due to his knees, but he did play 27 games in left field with Oakland this past season.
- Drooling over Miguel Sano’s incredible numbers through 50 career games 9
- Matt Williams puts up another strong performance in his quest to get himself fired 87
- Settling the Scores: Tuesday’s results 63
- Yankees reveal Mark Teixeira’s shin injury is “more than we thought” 15
- There’s a chicken pox outbreak in the Royals’ clubhouse and multiple players are infected 27
- Shoeless Joe Jackson is not being reinstated 66
- And That Happened: Monday’s scores and highlights 66
- Cubs acquire Austin Jackson from Mariners 22
- Sarah Palin sticks up for Curt Schilling, tells ESPN to “stick to sports” (266)
- Dan Patrick: When does ESPN cut ties with Curt Schilling? (202)
- Curt Schilling taken off of ESPN’s Sunday Night Baseball telecast this week (134)
- Joe Girardi would like Carlos Gomez to “play the game right” (97)
- Matt Williams puts up another strong performance in his quest to get himself fired (92)


08-27-11, 07:35 AM
So what's the deal with this tomfoolery?
Mine does nothing (Naturally) But I have the autolevel compressor (How do I test it)
What else should I expect to go through in playing around with this project.
Also, in the event I need new autolevel-compatible shocks, where should I look? I have always seen the ones clearly labeled as NOT to be used with autolevel features and have heard stories of several people who purchased their cars and realized previous owners changed them to unfriendly shocks.
08-27-11, 09:02 AM
I would see if Chris at Rippy can get you a set. He quoted me like $75 for a set for my car, which is a really good deal (I keep forgetting to call and officially order them tho). Usually the "real", oil-filled part of the shock goes bad though, not the air part. If you do have an air leak it's usually a fitting or a line.
I don't know if your setup is like the '93-96, but it's a pretty simple arrangement. There are fuses, obviously, so I'd check that first. On my '94 there was a fuse for the sensor (said "ELC") in the dash fuse panel and another for the pump itself under the hood. The system gets a constant hot so that the car is always trying to level itself. In the event you have a big leak, the compressor will shut itself off after 4-7 minutes to keep from draining the battery. There's also a key-on lead at the sensor so that it knows when you've started the car. 45-60 seconds after you start the car the pump puts some fresh air in the system. It will vent briefly and then pump some fresh air into it.
There's a sensor mounted in the most inconvenient place possible above the rear axle. It's attached to the frame and has an arm attached to the axle. This is how it measures ride height. Too low, it calls for the pump to run. Too high and it opens an exhaust valve on the pump. In both scenarios the sensor is simply completing a ground so you want to make sure the ground wire at the sensor is grounded. If that checks out okay, the next check is to ground the pump-on wire at the sensor (it's yellow on the '93-96 cars). If you ground it and the pump runs then the problem is the sensor. If it doesn't, move up front to the pump.
I don't know where the pump is on the pre-93 cars, but on the '93-96 it's mounted in front of the left front wheel. You need to remove the plastic trim to get at it. On the pump housing there's a relay to make it run. You'll see where that yellow wire from the sensor goes into it (again, your wire colors may vary). If you ground it at the pump and it runs then you have break in the wire between the sensor and the pump (not a likely scenario, but that was the problem with my car). The yellow wire also illuminates the "LEVEL RIDE" light in the dash (again, this could be a '93-96 thing). Next, bypass the relay by hooking the pump leads up directly to 12V to see if the pump runs. If it doesn't run, then the pump is dead. If it DOES run, then the relay is bad.
Above is a summary of the steps that the factory service manual takes you through. My advice, however, is to verify that the fuses are okay first then find the pump and hook it up directly to 12V. Usually it's the pump that's gone bad (seized up).


text:
Big Dummy no more!
December 8, 2013 11:18 AM Subscribe
This is a question about the musician Quincy Jones.
posted by jason's_planet to Society & Culture (9 answers total) 2 users marked this as a favorite
The only song of Quincy Jones' with which I am familiar is the Sanford and Son theme, aka "The Streetbeater."
It is my understanding that there is a lot
more to Mr. Jones' ouevre than this, that only knowing this one song is kind of like only knowing one of William Faulkner's dirty limericks.
So if I wanted to get to know his music a little better, where would I start? What are good albums for a beginner?
Many thanks in advance. Happy Holidays!


text:
Twitter was bubbling with conversation on Friday morning (Sept. 3) after the release of Drake’s long-awaited sixth studio album, Certified Lover Boy. As reported by REVOLT, the 21-song LP arrived early Friday morning boasting features from JAY-Z, Lil Wayne, Rick Ross, Kid Cudi, Travis Scott, 21 Savage, Lil Baby and several others, including a sampled Nicki Minaj verse.
Online, fans reacted to the album’s star-studded list of collaborators, lyrical name-drops and sounded off on their favorite tracks.
“This Drake Certified Lover Boy album is a classic already,” one person tweeted.
“Drake knows what people want/like and just delivers it over and over again,” another added.
On Twitter, several of the album’s collaborators, songs and “Aubrey” — Drake’s birth name — began to trend. By 10 a.m. EST on Friday, “Girls Like Girls,” a CLB cut featuring Lil Baby, was No. 1 on Spotify’s Top Hits chart.
Certified Lover Boy was initially expected to arrive back in January, but was postponed after Drake suffered a leg injury. The 34-year-old began ramping up his album rollout efforts late last month and officially announced the project’s release date with a cryptic stunt on SportsCenter.
Then, earlier this week, fans began noticing billboards popping up in several major cities that appeared to announce Drake’s list of CLB collaborators. As we reported, a billboard in New York promised “the goat” would be featured on the album while a Houston sign hinted at the city’s “hometown hero,” the two of which turned out to be Hov and Scott, respectively.
One billboard in Drizzy’s home city of Toronto noted Weezy’s appearance, reading, “Hey Toronto, the best rapper alive signed me in 2009 and is on CLB.” Other signs revealed the inclusion of Young Thug, Project Pat, Yebba, Lil Durk, Giveon, Ty Dolla $ign and more.
Now that Certified Lover Boy is finally here, see fans’ reactions to the album on Twitter below.

domain: celebrity


text:
Orwellian Newspeak is doing well. There’s a Bush administration proposal to issue an executive directive that would protect pro-life health care providers from discrimination for refusal to perform or assist in abortions or sterilizations, embryonic stem cell research activity, or any other morally objectionable activity. The Equal Employment Opportunity Commission, however, complains the proposal would overturn “40 years of civil rights law prohibiting job discrimination based on religion.”
According to the Commission, the Civil Rights Act of 1964 already prohibits employment discrimination based on religion or personal moral convictions. But…pharmaceutical chains, for instance, might be stuck with employees who refused to fill prescriptions for abortifacient contraceptives. A “freedom of conscience” ruling might exempt Catholic hospitals from a Connecticut law requiring hospitals to provide rape victims with information about emergency contraception – that is, chemical abortions.
Well, yes, that would seem to be the idea, wouldn’t it?
The next objection is that while President-elect Barack Obama could – and he’s said that he would – rescind such a directive, the process could take several months, as federal law requires a counter rule and public comment. It would “set the stage for an abortion controversy in the early months of Barack Obama's administration,” wrote the LA Times.
Obviously, that would be uncomfortable for the Obama administration and Hillary Clinton, slated to be Secretary of State, has introduced legislation of her own, called the “Protecting Patients and Health Care Act,” to block the regulation. Stay tuned.
Stephanie Block is the editor of Los Pequenos - a New Mexico-based publication. Her columns are made possible by the sponsorship of generous individuals who believe information about the development and dissemination of progressive ideology needs to be more widely understood. Please fell free to share -- acknowledging authorship -- these articles with others. If you would like more frequent publication of Stephanie Block's work, tax-deductible donations can be sent to: Catholic Media Coalition - PO Box 427 Great Cacapon, WV 25422 Attn: Progressive Watch

domain: sociology


text:
The top ranking education systems in the world aren't there by accident. Here's how Australia can climb up
If You Need Money Now and are Worried about Finances, take a Look at How Much You’re Paying for Your Utilities
MINDBODY Named to Deloitte’s 2016 Technology Fast 500™
SAN LUIS OBISPO, Calif., Nov. 17, 2016 -- MINDBODY, Inc. (NASDAQ:MB), the leading provider of cloud-based business management software to the wellness services industry, has been included in Deloitte’s Technology Fast 500™, ranking 338 on this list of the 500 fastest growing technology, media, telecommunications, life sciences and energy tech companies in North America. 2016 is the fifth time MINDBODY has appeared on the Fast 500 list, previously ranking in 2010, 2011, 2012 and 2013.
MINDBODY’s cloud-based business management solution helps business owners in the wellness services industry boost revenue, streamline operations and access their critical business data from any web-connected device. Over the past few years the company has expanded its software platform to include multiple mobile app offerings including mobile business management and branded mobile app solutions. In addition, the consumer-facing MINDBODY app connects hundreds of thousands of wellness providers to millions of people around the world seeking their services.
“One of our core values and guiding principles is to continuously evolve, and our long term ranking on this list reflects that commitment,” said Rick Stollmeyer, MINDBODY CEO and Co-founder. “Our ongoing investments in growth and innovation enable us to serve ever-widening circles of wellness businesses, consumers and technology partners. In that way, we are connecting the world of wellness.”
Deloitte’s 2016 Technology Fast 500 award winners are selected among both private and public companies throughout North America with rankings based on percentage fiscal year revenue growth from 2012 to 2015. MINDBODY grew 217 percent during this time period.
To be eligible for Technology Fast 500 recognition, companies must own proprietary intellectual property or technology that is sold to customers in products that contribute to a majority of the company's operating revenues. Companies must have base-year operating revenues of at least $50,000 USD, and current-year operating revenues of at least $5 million USD. Additionally, companies must be in business for a minimum of four years and be headquartered within North America.
MINDBODY, Inc. (NASDAQ:MB) is the leading provider of cloud-based business management software for the wellness services industry and an emerging consumer marketplace. Over 58,000 local businesses and 326,000 wellness practitioners in over 130 countries and territories use MINDBODY's integrated software and payments platform to run, market and build their businesses. These practitioners provide a variety of wellness services to approximately 35 million active consumers who use the MINDBODY platform to more easily evaluate, engage and transact with them to live healthier and happier lives. For more information, visit mindbodyonline.com.
© 2016 MINDBODY, Inc. All rights reserved. MINDBODY, the Enso logo and Love Your Business are trademarks or registered trademarks of MINDBODY, Inc. in the United States and/or other countries. Other company and product names may be trademarks of the respective companies with which they are associated.
Media Contact: Tracy Richmond [email protected] 805-586-3226
Tesla Cybertruck update: Is Elon Musk's futuristic pickup truck joining the 'Cyberpunk 2077' vehicle lineup?


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NAA sells them: https://northamericanarms.com/parts/parts-cb/
They are 30 grain lead balls
I think doing a RN mold if you can find one is the way to go IMO. You could possibly create a 40 grain projectile to up the performance over the round ones. I believe they are right around .221-.222 in diameter but you would probably need to mic the chambers and bore if the specs aren't available.


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At last, I had time to mix an idea that was actually ready in March. But other things were given priority.
This epic piece of music called Cinematic Adventure was initially a test with some string instruments I had on my computer. I wanted to try to make a melody of epic and patriotic elements to upload on Pond5. And I think I’ve managed well. It has the elements needed to lift a scene in a movie, TV series or video game. It will be fun and see how it’s received.
I’ve been thinking about upgrading my library of bugs & trumpets, but good plugins cost a lot. So I’ll have a good time with those I have. They are not bad – but I always want to find faster ways to get a good sound.
You can download preview and buy Cinematic Adventure on Pond5.


[Mono-list] InteropServices: DllNotFoundException...?
Simon Ask Ulsnes
Sun, 23 May 2004 17:37:33 +0200
Hooray for Managed Code! ;-)
Could you please give a short example of a C++ library function that
returns a string for use in a managed application? (with proper memory
Jonathan Pryor wrote:
>On Sun, 2004-05-23 at 10:56, Simon Ask Ulsnes wrote:
>>>Furthermore, if you do something like this:
>>> const char*
>>> std::string s ("this is my string");
>>> return s.c_str();
>>>You're *asking* for trouble, as the std::string destructor will free the
>>>memory used to hold the string, so the string returned by
>>>get_my_string() will be pointing to invalid memory.
>>And guess what, that's actually what I'm doing (basically) - so far, it
>>works, I haven't detected any memory leaks (haven't checked very
>>But you say using marshalling and IntPtr's is the best way to do it?
>The above situation isn't a memory leak, so it won't be detected as a
>memory leak. It's instead a "use after free". It's akin to doing this:
> char *mem = malloc (20); // allocate
> strcpy(mem, "some string"); // initialize
> free (mem); // free
> printf ("this is my string: %s\n", mem); // use?! bad.
>It's not safe to use memory after it's freed. Especially in a
>multi-threaded environment -- the memory could have been re-allocated by
>another thread and initialized with different data.
>So this isn't a memory corruption bug or a memory leak, it's just bad
> - Jon
>Mono-list maillist - firstname.lastname@example.org


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Police say depressed doc tried to shoot psychiatrist
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A doctor, who police said is suffering from depression, attempted to shoot a psychiatrist in the OPD of a private hospital in Sahibabad, Ghaziabad, on Thursday afternoon.
Dr Kiran Pal, who has been arrested, had gone to consult psychiatrist Dr Sanjeev Gupta claiming he needed treatment for anxiety and stress, police said.
Superintendent of Police S S Yadav said Dr Pal complained of breathlessness and anxiety, and while Dr Gupta was checking him, he drew a pistol and attempted to shoot the psychiatrist.
According to Yadav, Dr Pal has claimed that he is suffering from depression because his divorce proceedings are underway. Dr Pal alleged that Dr Gupta, who knows his in-laws, had injected him with a "slow-acting poison".
Police said no one was injured since the hospital staff managed to overpower and disarm Dr Pal.
"The hospital staff hit Dr Pal with a fire extinguisher and also sprayed it on his face," Yadav said. Police said Dr Gupta denied the allegation of poisoning Dr Pal.
Yadav said: "Dr Gupta was going to check Dr Pal's pulse and blood pressure when the latter took out a gun and pointed it at Dr Gupta's head."
But the gun got stuck and Dr Pal could not shoot. "Dr Gupta ran out of the OPD and locked the accused inside. The accused managed to reload his gun and fired into the wall," Yadav said. "He is mentally unstable and has been suffering from a psychological ailment for a while," he said.


The Polk County Sheriff’s Office reported that crime in the first six months of the year is down 5.44 percent over the same time period of last year. And while the crime rate in Bartow is up, the 2.3 percent is 12 crimes.
In Bartow in the first six months of this year there were 531 reported crimes, according to the Uniform Crime Report prepared by the Florida Department of Law Enforcement. That compares with 519 the year before. By comparison to the last few years, during the first six months of 2011, there were 559 offenses and in 2010 there were 586.
“This is the first year we’ve gone up in many years,” said Michelle Jordan, who has been doing statistics for the Bartow Police Department for 14 years.
Also, according to Jordan, most of the crimes are in larceny, shoplifting and bicycle offenses — in other words, non-violent crimes.
To illustrate, in Bartow the number of larcenies in the first six months went up from 2012 to 2013 from 334 to 401. Shoplifting, which is in that category, went from 48 to 59 and bicycles went from 20 to 23. By comparasion to the number of crimes countywide, the number of larcenies came down from 2,544 to 2,450.
Being a smaller town may have some part in it but for Lyn Bryan, who does a lot of work with crime statistics for Bartow, there’s something more to it.
“Bartow is unique,” she said. “Most people who live here have been here a long time and look out for each other. People who live in my neighborhood do that. In bigger towns, people may not be always looking out for you. In some neighborhoods, we don’t have a formal crime watch but people do what crime watches do.”
Also she said much of the crime that occurs in Bartow is the result of people not necessarily taking care of their things as they should.
“For the year for the burglaries into vehicles, in 75 percent of them the door is not locked,” she said.
She said the same is true with houses. Most burglaries happen during the day. People can monitor over weeks when a house is generally empty for a long period of time and use that.
“They look for an easy way in,” she siad. “Lock, lock, lock it up. Use good lighting and make it look like someone is home during the day. That’s our biggest problem.”
In terms of burglaries in Bartow, the numbers went down 106 to 63 in the first six months, the UCR reports show.
In robbery, the numbers went down from 11 to seven. In forcible fondling, the numbers went down from nine to three. In Forcible rape the numbers went up from one to three and in murder, the number stayed the same at one.
In the forcible rape category, Jordan pointed out the FDLE changed its reporting this year where it had physical sodomy under a separate category that is combined with forcible rape now.
Meanwhile, the sheriff’s office, which generally doesn’t cover crime in Bartow, but does in Fort Meade and some other cities which don’t have their own police departments, the crime rate, which is the number of crimes per 100 residents, in 2012 was 2.48. This is the lowest crime rate ever measured in the Polk County Sheriff’s Office jurisdiction, breaking the previous record low of 2.70 crimes per 100 from 2011. Reliable crime statistics in Polk County started in 1971, when the crime rate was recorded at 4.16 crimes per 100.
Since 1997, the crime rate in Polk County has fallen by 62.9 percent, the UCR reports.
The UCR statistics reported were 267 fewer crimes overall in the first six months of 2013 than in the first six months of 2012 in the Sheriff’s Office primary jurisdiction. There were 4,645 crimes in the first half of 2013, as compared to 4,912 crimes in the first half of 2012. Compared to two years ago (2011), crime in the first six months of 2013 is down 13 percent.
According to the UCR comparison, the number of non-violent crimes went down 312 crimes — from 4,340 crimes to 4,028 crimes, a reduction of 7.19 percent. Non-violent crimes include burglaries, larcenies, and motor vehicle thefts.
Homicides were down 70 percent from 10 to three homicides comparing the two semi-annual statistics.
“The statistics don’t lie, crime continues to decline in unincorporated Polk County. There are several key reasons for this success, including our valuable partnerships with the communty; our proactive approach to solving crime trends before they become an issue; and the fact that we work hard every day to prove to the people of Polk County that we are committed to excellence,” said Sheriff Grady Judd.


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Revolutionary Girl Utena Episode 19 English Subbed
You are watching Revolutionary Girl Utena Episode 19 English Subbed from the Revolutionary Girl Utena Anime Show. Watch or Download Revolutionary Girl Utena Episode 19 MP4 English Sub and other episodes of Revolutionary Girl Utena Streamed for Free.
"The Song of the Fallen Kingdom"
Episode Summary: When Wakaba was little, she had a friend who protected her from bullies. Now, Tatsuya has transferred back, and it appears that the two of them are in love. When it turns out that this romance is actually a misunderstanding, Tatsuya ends up at the Mikage Seminar, but Mikage treats him differently from other students who visit.


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Looks like Jed Hoyer isn’t asleep at the wheel after all. As first reported by Jeff Passan, the Cubs have agreed to a one-year deal with righty reliever Hector Neris that has an option for a second year. Neris is guaranteed $9 million and there’s a $9 million club option for 2025 that converts to a player option at 60 appearances. With incentives, the deal can max out at $23.25 million.
This is just the Cubs’ second guaranteed signing of the offseason after adding lefty starter Shōta Imanaga just before his posting window closed earlier this month. Neris lends a ton of credibility to a bullpen that was pretty iffy leading up to Julian Merryweather and Adbert Alzolay at the back end, so Hoyer just solidified what had been a league-average unit last season. They sure could use another lefty, though, so maybe we see a trade in the next couple weeks.
The Marlins are pinching pennies and are surely open to dealing an arbitration-eligible player or two, with Tanner Scott standing out as a nice fit for the Cubs. Scott has appeared in over 60 games in each of the last three seasons and he’s coming off of a career-low 7.8% walk rate with just three homers allowed in 2023.
But back to Neris, who enters his age-35 season looking for a ninth consecutive year of double-digit K/9 marks. He has appeared in more than 70 games in each of the last three seasons between Houston and Philadelphia, prior to which he logged at least 68 appearances three other times. His fastball velocity dipped a little last year to just 93 mph, though batters had a mere .153 average against it.
His splitter induced a whopping 42.2% whiff rate as it tumbled to the bottom of the zone thanks to a spin rate of just 1,166 rpm. That’s not the lowest in the game, but it’s really darn good and it helps Neris to be relatively split-neutral. He works the four-seam up in the zone while the splitter works down, then he busts righties in on the hands with the sinker. That means he also works lefties away, which is how he’s been more effective against them over the last two seasons.
Though Neris doesn’t throw the splitter as frequently as he did with the Phillies, when it made up well over 40% of his offerings, he’s been far more consistent of late. Say all you want about their competitive methods, the Astros have been phenomenal when it comes to developing pitchers in both the minors and big leagues. Continuing that performance with the Cubs will make Neris a very valuable member of the bullpen this season and possibly next.
There are some concerns, however, the biggest of which is that velocity dip for a guy who’s several years on the wrong side of 30. Neris also walks a fair number of batters and gives up a ton of fly balls, with something like 45% of the contact he’s allowed over the last three seasons ending up in the air. That mark was nearly 52% last year, but he was able to limit damage thanks to his 97th-percentile hard-hit rate. Regression, please hold off for a while.
With the back third of games spoken for and a host of middle relievers and swingmen, the Cubs have a fair bit of depth to work with. Having a pitcher or two take a big step forward, whether that’s Daniel Palencia, Luke Little, or one of their host of minor-league signings like Carl Edwards Jr. would answer a lot of questions. This deal pretty much removes any remaining flexibility they had, so it’s going to be a real battle this spring in Mesa for one or two spots.
Now Hoyer’s job is to find some more offense to make sure the ‘pen has enough leads to protect this season.


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At-home quarantine piloted among F1 individuals in hotspots
|Vietnam Times and benefactors support Bac Giang battle against Covid-19|
|Health Minister calls for medical students to assist Bac Giang, Bac Ninh in Covid-19 fight|
|In Photos: Coronavirus-hit Bac Giang deserted during social distancing|
|Industrial workers in Bac Giang waits for Covid-19 vaccine injection (Photo: Thanh Nien)|
Bac Giang and Bac Ninh provinces are piloting home quarantine among low-risk F1 group (those having direct contact with Covid patients) who live in areas under blockade or social distancing. Meanwhile, all F1s categorized as high-risk would enter quarantine centers as normal.
Deputy Health Minister Do Xuan Tuyen on Friday afternoon called for provincial authorities to form quick response teams to collect and analyze Covid-related information for better contact tracing results. All industrial workers at the two provinces must install the contact-tracing app Bluezone to make daily health declaration.
The Ministry of Health also permitted households in blockaded or socially distanced areas to keep producing and harvesting at their place as long as it’s well-ventilated and has a good sanitation system.
All households must strictly follow Covid-19 prevention and control protocols during the stay at home. Regular disinfection around the house and production equipment is encouraged. Family members are also advised against having physical contact with neighbors.
The piloting program, which is carried out for the first time, would likely ease the burdens of infrastructures and human resources at centralized quarantine zones, as well as reduce the cross-infection rate.
|Medical staff takes workers' samples for Covid-19 tests in Bac Giang (Photo: VNE)|
Vietnam is in the grip of the fourth Covid-19 outbreak which started on April 27. Since then, 3,644 infections have been reported across 33 provinces and cities, claiming 12 lives. The two northern provinces Bac Giang and Bac Ninh are the hardest-hit, with 1,927 and 736 cases respectively. Record new infections have continuously documented every day, most are linked to clusters at industrial parks.
The health ministry has been sending top medical experts, military forces, and volunteers to help local personnel stamp out the outbreaks. It also prioritizes thousands of vaccine doses for local industrial workers, and 12 graders and exam officers who are about to sit for the national high school exams in July.
Medical officials have been going all out to speed up contact tracing and testing efforts. Field hospitals have been set up at “lightning speed” in both provinces. On the night of May 27, over 500 coronavirus patients in Bac Giang were transferred to the provincial makeshift hospital for treatment.
Bac Giang has reportedly prepared response plans for a 5000-patient scenario. Bac Ninh is also ready to admit and treat 3,000 Covid patients.
“The fourth wave is more challenging than the three previous ones combined,” Deputy Prime Minister Vu Duc Dam said.
Covid-19 patients in Bac Giang transferred to field hospital overnight (Photo: VNE)
Vietnam’s current wave has been predicted as more prolonged and complicated. However, it has basically been put under control as most of the new cases are either under quarantine or from blockaded areas. Infection sources have also been effectively traced.
The government on Thursday negotiated for allocation of Moderna vaccine from Zuellig Pharma company. The move aimed to help Vietnam step up its nationwide vaccine rollout plan.
According to the health ministry, Vietnam was less prioritized for coronavirus vaccines than countries with poor pandemic management. Therefore, it has also been working on solutions to have better vaccine access, including removing vaccine export bans, encouraging foreign enterprises to purchase vaccines themselves to immunize their workers, among others.
|Vietnamese peacekeepers and the fight against Covid-19 |
The Covid-19 pandemic has affected Vietnamese “blue beret” soldiers in performing the UN peacekeeping mission. To ensure safety for them, the relevant agencies have made ...
|22-year-old woman becomes Vietnam’s youngest Covid death |
The patient succumbed to the novel virus over three weeks after contraction.
|New hybrid nCoV variant appears in Vietnam |
A recombinant nCoV variant, formed by mashups of the Indian and British variants, has appeared in Vietnam. The new variant is highly transmissible and can ...


Blake Garden (Kensington, California) facts for kids
Quick facts for kidsBlake Garden
|Lua error in Module:Location_map at line 420: attempt to index field 'wikibase' (a nil value).|
|Location||Kensington, California, United States|
|Nearest city||Kensington, California|
|Area||10.6 acres (4.3 ha)|
|Status||Open year round|
|Website||Official Blake Garden website|
Blake Garden is a 10.6 acre (4.3 ha) landscape laboratory and public garden located at 70 Rincon Road in Kensington, California, United States. It is a teaching facility for the Department of Landscape Architecture and Environmental Planning of the University of California, Berkeley. It is also the site of Blake House, formerly the residence of the President of the University of California. The garden is open to the public during weekdays; no admission fee is charged.
The Blakes' original family home was on Piedmont Avenue, where Memorial Stadium now stands. The building of the stadium prompted the building of two homes in the Kensington hills, Anson Blake's house, now Blake Garden, and the Edwin Blake house, now the Carmelite Monastery. The garden was deeded to the Landscape Architecture Department in 1957 by Anson and Anita Blake, and title passed to the University upon Anita Blake's death in 1962. Five years later, Blake House became the UC President's official residence, until 2009.
The siting of Blake house is integral to the garden's design: it shelters the Formal Garden from the strong prevailing winds off the Golden Gate. The grounds for both estates were designed by Mrs. Blake's sister, Mabel Symmes, who graduated from the university's Landscape Architecture Department in 1914. Ms. Symmes' original plan showed great sensitivity to the site. Much of her original plan can still be seen in the design of the Pink and Yellow Gardens with its grotto, inspired by the Villa Tusculana at Frascati, Italy and the reflecting pool which was part of a system to take advantage of underground water. The Redwood Canyon, with redwood cuttings brought from the Blake's property in Berkeley and St. Helena, is planted along a natural waterway. The original plan also shows a lake in the Australian Hollow, taking advantage of the high water table in that part of the garden. In 2010 this area was restored to a native wetland by UC students, volunteers and Blake Garden staff. The wetland now provides habitat to a community of Pacific chorus frogs and area birds.
Other parts of the garden include the Mediterranean Garden on the western side of house, a showcase of drought-tolerant plants from the world's Mediterranean climates; the Cottage Garden, full of roses, flowers for cutting, vegetables and herbs; the Square, with its water lily-filled pond, and beds brimming with low-water perennials; and the Event Lawn and surrounding beds, another example of water-smart gardening.
The garden is home to nearly 1500 plant species, over fifty bird species, as well as raccoons, frogs, salamanders, and the occasional fox. The garden is all organic, with many sustainable practices including four kinds of composting, rainwater harvesting, and hives of honeybees. Additionally, the Create with Nature Zone offers a space for visitors of all ages to experiment and build with materials collected from the garden.
Blake Garden (Kensington, California) Facts for Kids. Kiddle Encyclopedia.


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PSL Business Women are stronger together fundraising for breast cancer research
The Port St. Lucie Business Women were among the top 10 out of 95 fundraising teams at the annual Making Strides Against Breast Cancer walk Oct. 28 at First Data Field. The group also sponsored a water station.
“With a community organization such as the Port St. Lucie Business Women joining us and our community in the fight against breast cancer, we can continue to help survivors live to see another day, share their stories, be able to see their grandchildren or children grow, bring awareness, provide free rides to cancer patients to treatments and so much more,” said Danielle Shalginewicz, American Cancer Society’s Southeast Region community development manager. “Together, we can make a difference; together, we are making a difference.”
“No One Walks Alone: We are Stronger Together” was the Business Women team’s theme this year. Below that message, the word “hope,” with the letter “o” formed by a twisted ribbon consisting of figures representing the Business Women, reinforced the message.
The Port St. Lucie Business Women’s custom team t-shirts were designed by Business Women member Diane Gallagher and donated by both Aztec Graphix and Holley Surgical Arts.
Breast cancer is the second leading cause of cancer death in women, exceeded only by lung cancer. Women have a one-in-eight chance of developing invasive breast cancer. Since 1989, breast cancer death rates have declined by 38 percent, yet one in 36 women will die from this disease. Finding a cure is critical.
Thanks to improvements in treatment and early detection, more women – and men -- are surviving breast cancer today. The Port St. Lucie Business Women is proud to support the American Cancer Society’s search for a cure, education and outreach.
The Port St. Lucie Business Women is a 37-year-old professional organization dedicated to promoting the interests of business women and serving the community in an effective way. For more information visit www.pslbw.com. "Like" its Facebook page for updates about events, programs and community involvement.

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I grumbled as a child and thought "why so much of non love around..and watched the world in shock and thought.. Oh..what a mess !" ! And grew up to be a youngster who walked my path and the world quickly branded me as a "rebel" !! The world said "use your brains.." And i said "sorry folks..i have none". For i flow with the language of heart !!!! And it brings much pain to walk a different path. And some months ago on a lovely dewy morning..i took a walk as usual..and grumbled like a child again"why why ? why did i come here to this earth in such dense conditions ?" Kicked the stones harder !! Gritted my teeth !Then the breeze blew gently.. as if it held the secret. It teased..And perhaps chuckled and said " You love this ? Dont you ? You came here because you wanted a tough game to play. You wanted a tough adventure. And you came here because you love the creation . This is not the first time..And this will not be the last time.Your soul carries a WARRIOR S SIGNATURE ! You travel across the creation and break the old conventions holding the torch of love in the midst of dense conditons. Come rain or sunshine..the spark in your heart glows..WARRIOR" !! I smiled and realised yes.. this wont be the last time i will do this.. may take breaks "in another dimension" and keep coming back when there is a war between Light and the Dark..To accept the dark and transmute it into love. To keep the doors of heart open like a highway. To talk the language of heart.
Many of you out there perhaps feel the same :-) Many of you would have come here to spread LOVE. So what is your soul signature ? :-)