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Bashkir director will present his film at the International Film Festival Zerkalo
From June 10 to 15, the VIII International Andrei Tarkovsky Film Festival will be held in Ivanovo. The most participants of the program of short films "Nachalo" are graduates of directors laboratory "Kultbyuro". As the website of the laboratory informs, young directors from different Russian cities will present their films to the festival audience and will participate in a roundtable discussion on the development of the film industry in the regions.
Among them there is a Bashkir director, participant and winner of many festivals Ainur Askarov, who will present his film "Bitter Honey".
The program of the International Film Festival Zerkalo includes display of the best works of auteur cinema, international competition, Russian films, new films in the genres of documentary, animation, video, poetry program of Vera Polozkova, readings of columnists of "Russian Pioneer" magazine, exhibitions, meetings, round tables and workshops of movie industry professionals.


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More than 230 people from businesses across Yorkshire have raised £12,650 for the Marie Curie Hospice in Bradford after taking part in the fourth annual Wharfedale Ton charity cycling challenge.
Amateur cyclists participated in the 100-mile ride from Ilkley to York and back again. The event has now raised more than £43,500 for the hospice since its launch in 2016.
The Wharfedale Ton was created by Yorkshire law firm Gordons, Lloyds Bank and audit, tax and consulting firm RSM. Around 120 people took part in the inaugural event.
Marie Curie Hospice in Bradford provides specialist care and support for people living with a terminal illness and their families.
Marie Curie Yorkshire fundraising manager Liz Howlett said “The Wharfdale Ton continues to raise a fantastic amount of money and awareness for the hospice here in Bradford. Thank you to everyone involved in making this year’s event such a huge success.”
“We have recently completed a £1.5 million refurbishment at the hospice which has transformed our day therapy unit into a state-of-the-art outpatient facility that will improve the care received by terminally ill patients across Bradford. We are so grateful for all the hard work and effort that everyone involved with the Wharfedale Ton puts in to raise these valuable funds which will help support our work both in the new unit and across the rest of the hospice.”
The hospice offers several different services, including a 16-bed in-patient unit and also out-patient services incorporating a variety of different activities.
Support for families and carers is available, as the hospice also provides vital spiritual and emotional support, including recently extended and expanded bereavement support.
Gordons partner Philip Paget said: “Support and appreciation for the Wharfdale Ton increases every year. This year was no different with 230 people participating. Its success comes down to the generosity of all involved—the riders who took part, our corporate sponsors and local businesses who helped organise the event.”
“Marie Curie provides vital services for people living with a terminal illness, and their families, in Bradford. The money raised this year is enough to fund the running of the entire hospice for two full days.”
The Wharfedale Ton for 2019 took riders on a figure-of-eight route through scenic Yorkshire countryside, taking in Wharfedale to a lunch stop in York, and returning via Little Ouseburn, Wetherby and Sicklinghall back to Ilkley.

domain: news


text: New Era Japan know what time it is! They just have just released this New Era branded watch, so now you can match the sticker on your visor with your timepiece! This watch keeps it simple and classic; with no fancy screen, apps, or design. It features black band, with a 59FIFTY sticker style face – a perfect design for all true fitted heads. Who said the iconic New Era 59FIFTY sticker could only be worn exclusively on your hat? Not you can wear it on your wrist! This summer, #FlyYourOwnTime in style. Purchase this watch today at New Era Japan. Don’t be late!

domain: design


Dear Friends of Ask Coach Wolff:
I wanted to tell you about a new and different kind of podcast. It’s entitled “Old School v. New School” and it features my new son-in-law, Noah Savage, and myself. Noah is a 31-year-old 6-7 former All-Ivy League basketball player at Princeton, and I think it’s safe to say that he represents a new and different way of looking at the world of sports. He is most definitely “New School.”
And as for me, I’m considerably older than Noah, and of course, my views on sports tend to be a little more on the conservative side. Thus, I’m “Old School.”
In any event, Noah and I take on timely and controversial topics in sports, and we discuss our views in a new podcast series. It’s a lot of fun and clearly different in scope. I would urge you all to sign up (see below – it’s easy), and then tell all your friends to listen in as well.
There’s several ways to listen:
ON THE COMPUTER
It’s available on Itunes and you can listen by clicking this link http://oldschoolnewschool.
ON IPHONE by searching “Old School New School” on your podcast app on your Iphone. (It is the purple icon that says “podcast” on it) If you subscribe then the newest episodes will update each time you open that app and click “feed.”
Please click “Subscribe” then rate and review it!
We will release a new episode every Friday morning so that you can power through that last workday of the week.
Here’s a quick description:
Old School / New School is a new podcast where two sports broadcasters- Rick Wolff and Noah Savage – debate today’s most controversial and pressing sports issues from two very different perspectives – most notably that Wolff, in his 60s, is definitely “old school” whereas Savage, 31, is clearly “new school.” Oh, and Noah happens to be Rick’s son-in-law.


Merck seeks first U.S. authorization for COVID-19 pill
Reuters, 12 Oct 2021
Merck said it has applied for U.S. emergency use authorization for its tablet to treat mild-to-moderate patients of COVID-19, putting it on course to become the first oral antiviral medication for the disease.
#COVID #Merck #COVIDTablet #News #Reuters
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While you may drink the water from your tap at home, it likely contains chemicals, bacteria, and other contaminants. Your water will taste better and be healthier to drink when you use a home water filter. There are different types of home water filters to choose from, a few of which we’ve outlined below.
Comparing Home Water Filters
Different types of water filters target and remove specific contaminants. So, you don’t want to choose a water filter without first knowing what your water contains.
If you choose a UV water filter that kills bacteria, but you don’t have microorganisms in your drinking water, you’ll be wasting your money. There may be unsafe levels of lead in your water, but not all water filters remove heavy metals.
Have your home’s tap water tested by a professional and consult the results before choosing a water filter.
1. Activated Carbon Home Water Filters
An activated carbon filter is the most common type of water filter. This technology is used in most built-in refrigerator filters and is readily available in pitchers and faucet attachments.
Activated carbon removes contaminants like chlorine, which is added to most municipal water, pesticides, volatile organic compounds (VOCs), and sediment. It does not remove heavy metals, salts, or microorganisms.
2. Reverse Osmosis System
One of the most thorough home water filter options is a reverse osmosis system. This is one of the few water filter systems that remove fluoride, which is added to most water by municipalities.
It also removes heavy metals, salts, bacteria, nitrates, sulfates, pharmaceuticals, and pesticides. One drawback of a reverse osmosis system is that it wastes a lot of water.
3. UV Water Purifiers
An ultraviolet water purifier uses UV light to destroy the DNA of microorganisms, like bacteria, viruses, and microbial cysts. Some areas have higher concentrations of microorganisms than others, so determine if you could benefit from a UV water purifier by having your water tested.
Drinking plenty of water is important for your health, but you want to make sure that your water doesn’t contain harmful pollutants and toxins. Have your water tested by a professional first, and then install a water filter.


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4 red bell peppers, halved and seeded
1/3 cup olive oil
3 tbsp balsamic vinegar
6 large basil leaves, thinly sliced crosswise
4 cloves garlic, thinly sliced lengthwise
2 oz creamy goat cheese, cut into 4 slices
1 tbsp Moroccan Cinnamon Spice Blend
- Place bell pepper halves cut side down on a baking sheet. Broil in preheated oven on top rack directly under heat, turning pan often, for 5 to 8 minutes, until skin is evenly charred.
- Meanwhile, in a bowl, whisk together oil, vinegar, basil and garlic. Set aside.
- Remove blackened peppers from oven. Set baking sheet on a cooling rack and cover peppers with a clean towel. Let cool. Remove the charred skins from the peppers. They should slip off easily when rubbed. Slice pepper halves into 1/2 inch (1 cm) wide strips and place in bowl with oil mixture. Toss pepper slices to coat evenly. Cover dish tightly with plastic wrap and marinate for at least 2 hours at room temperature or for up to 3 days in the refrigerator.
- Tip roasted peppers into the bottom of a small tagine. Heat over low heat until bubbling.
- Place cheese slices on top of the peppers. Cover with tagine lid and simmer for 5 to 7 minutes or until cheese is melted.
- Sprinkle spice blend over cheese and serve warm.
Recipe courtesy of 150 Best Tagine Recipes by Pat Crocker
Morocco [ print this recipe ]

domain: food


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Democrat Morgan Carroll is bringing in the big guns for the homestretch of her race against Republican Mike Coffman — President Barack Obama, appearing in an online-only ad for the Colorado state senator.
The spot starts Wednesday and runs through Election Day; in it, Obama says Carroll and other Democrats “can get more done” in Congress on issues ranging from college affordability and “ending the corporate tax breaks that send good Colorado jobs overseas.”
The ad was funded by Carroll and the Democratic Congressional Campaign Committee and her staff said the run’s cost was in the “low six figures” but provided no more specifics.
Carroll is hardly alone in using the president for her campaign. In recent weeks, Obama has begun to play a bigger role in federal and state races nationwide.
In response to the ad, Coffman’s campaign released the following statement: “Morgan Carroll is the last person on the planet who unequivocally supports Obamacare, so the fact that the President took personal involvement for Morgan Carroll isn’t a particular surprise. This election is a Marine vs. Morgan Carroll, Nancy Pelosi, Bernie Sanders, Hillary Clinton and now the President of the United States. Our message to all of the above is — take your best shot. We are ready.”


Director of Marketing & Communications
Inspired By The Past Anniversary Season And Austrian Tour, Pacific Symphony Youth Wind Ensemble Opens 2017-18 With Nothing Less Daunting Than "Empires And Everything Else"
Orange County, Calif. — October 23, 2017
It will be difficult for Pacific Symphony Youth Wind Ensemble (PSYWE) to top last season’s milestone 10th anniversary, culminating in a triumphant European Tour, but if anyone can, it’s this highly talented group of young musicians. In 2016-17, PSYWE paid homage to the band tradition and the ensemble’s history in the Pacific Symphony family, and this season, they take that valuable experience and forge new roads along their musical journey—beginning with bravely tackling “Empires and Everything Else.” So, hold onto your armrests, as PSYWE’s opening program—swift, varied, diverse and exciting—begins and ends with works by Richard Wagner, sprinkles in Spanish gems, one English nugget, a little American Sousa—and everything else!
Led by Conductor Gregory X. Whitmore, PSYWE performs its first concert of the 2017-18 season on Sunday, Nov. 12, at 1 p.m., in the Renée and Henry Segerstrom Concert Hall. Thanks to the generosity of sponsors, this season’s concerts are free to attend, but tickets are required. To reserve a general admission seat, call the Symphony’s box office at (714) 755-5799 or visit www.PacificSymphony.org.
“Last season was a big one,” says Maestro Whitmore. “It was our 10th anniversary, a season full of collaborations, celebrations and a seminal tour of Austria. But 2017-18 is perhaps even more significant, as we undertake our second decade and an important time to cement the establishment of our first. We will present a season that is both current and classic, looking both forward and back. The overall theme reflects a return to works that celebrate cornerstones of the wind repertory, beginning with our concert, ‘Empires and Everything Else,’ which is quite varied!”
The program opens on a festive, traditional Spanish note, with a piece by Ferrer Ferran, born in Valencia, Spain, in 1966. A traditional Spanish pasodoble (a popular march played during the entrance of bullfighters, which literally translates as “two-step”), the work was dedicated to Consuelo Ciscar, a devotee of the Valencian culture. The music paints a picture of Ciscar’s flamboyant Spanish personality through its colorful harmony and orchestration, adding spice to any performance.
True to the concert’s programmatic ethos, it features works of empires. “The true empires of the past, the fictional, and the ‘not so much,’ ” notes Whitmore. Hardly any composer was as controversial (rejected and celebrated by his contemporaries) as Wagner. Musicologist Hugo Riemann described him as “the greatest dramatic composer of the 19th century.” The concert spotlights Wagner’s “Huldigungsmarsch” (Homage March), written in 1864 for military band in Starnberg, Germany, for the 19th birthday of his patron, King Ludwig II. The first of Wagner’s three large-scale marches, this was his principal contribution in his small legacy of works written for winds.
Next, the “William Byrd Suite,” showcases both Byrd (1540-1623), an English Renaissance composer, and Gordon Jacob (1895-1984), a 20th-century English composer who, along with Holst and Vaughan Williams, is known as an early champion of the wind band. Jacob assembled the suite in 1923, for the tricentennial of Byrd’s death, transcribing it from six pieces of Byrd’s keyboard work appearing in the Fitzwilliam Virginal Book, a collection of almost 300 pieces written between 1562-1612 by more than a dozen composers. Jacob artfully added dynamic shadings and instrumental color, for which the wind band is known.
Two more works of Spanish influence follow. First, a traditional bullfighting piece by Bernardino Bautista Monterde, “La Virgen de la Macarena” (for trumpet soloist and winds). This version of the famous Spanish song was arranged in 1902 by Rafael Mendez, in Cartagena, Spain, and is an homage to the Virgin of Seville, considered the protector of bullfighters. An ornate statue of her likeness is on display in the Basilica Macarena, with crystal tears down her face. During Easter week, travelers flock to witness processions of floats and gaze upon the weeping statue. One of Spain’s legendary matadors, Jose Ortega, presented the Virgin with five emerald brooches, hoping for protection. It worked for eight years ... until he was gored to death in the ring.
Antonio Alvarez’s “Suspiros de España” (Sighs of Spain), another pasodoble, is infused with Spanish-tinged melodies, harmonies and rhythms. Although written as an instrumental march, it has become popular to add lyrics to the tune and it has been sung and recorded by major Spanish singers. The sentiment of the music typically expresses the beauty of Spain and the desire of Spaniards away from home to return to its splendor.
After intermission is Sousa’s “The Inaugural March of President James A. Garfield.” The only two marches Sousa dedicated to U.S. presidents were composed for Garfield, marking the beginning and end of his short tenure. Whitmore says: “The programming of this work, the actual inaugural march of President Garfield, is significant in that this is the inaugural concert of PSYWE’s 11th season, and more importantly, this little-known work by Sousa is not often performed.”
Additionally, the concert features the William J. Gillespie Concert Organ for English composer Percy Grainger’s largest work for winds, “The Power of Rome in the Christian Heart.” Composed for organ soloist and wind ensemble, this piece was Grainger’s last original work for wind orchestra, commissioned in 1947 to commemorate the 25th anniversary of the League of Composers, and also the 70th birthday of Edwin Franko Goldman, an American band composer of the early 20th century, known for his marches.
To close, the program returns to Wagner with “Elsa’s Procession to the Cathedral” from the German Romantic opera, “Lohengrin,” which premiered in 1850. It tells the story of Elsa, a princess in Brabant (now Antwerp), who is rescued by Lohengrin, a mystic Knight of the Holy Grail. The procession marked the imminent betrothal of Elsa to her knight, who’d come to deliver the people of Brabant from Hungarian invaders. Drama and tragedy ensue in typical Wagnerian fashion. The music has become a staple of the band repertoire.
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State lawmakers haven’t finished an operating budget on time in eight years.
They’re about to get raises anyway.
On Wednesday, a citizen commission that sets elected officials’ salaries voted to increase Washington lawmakers’ pay by 2 percent each of the next two years. That adds up to roughly $2,000 per legislator between now and September 2018.
Right now, a rank-and-file member of the Legislature makes $46,839 per year. With the increases the salary commission approved Wednesday, those legislators’ annual salaries will rise to $47,776 in September, and to $48,731 in September 2018.
Lawmakers are locked in a 30-day special session after they were unable to approve a new two-year state budget during their regular session, which lasted 105 days. They haven’t been able to agree on a new two-year operating budget without going into overtime since 2009.
Several citizen members of the salary commission said their role isn’t to consider the performance or decision-making of individual politicians when setting salaries. Rather, the independent commission considers a range of factors, including job responsibilities and inflation, several members said.
“We’re not a political body. It’s very hard to keep separate our duties because we’re charged with setting salaries for elected officials, but we are not political,” said Melissa O’Neill Albert, one of the commission members. “So we should never be involved in a tit for tat.”
This year, Washington lawmakers are hung up on how to comply with a court order to fix how they pay for public schools, which has been haunting them since the state Supreme Court ruled five years ago the state was failing to meet its duty to basic education.
While some commission members thought the proposed increases for lawmakers were too high, others said it is clear that lawmakers are underpaid considering how much work they take on. Working as a state lawmaker is the equivalent of working about 70 percent of a full time job, commission members said, even though lawmakers are supposed to be in session for only a fraction of each year.
“I think they’re still underpaid, but this moves them a little closer to where we want them to go,” said Gregory Dallaire, vice chairman of the salary commission.
After extended debate, the salary commission decided to award lower raises of 1 percent per year to statewide elected officials, including the governor and attorney general.
Some members of the commission said they thought they shouldn’t give those better-paid elected officials — all of whom make more than $100,000 per year — substantially more money when their job responsibilities hadn’t changed.
“I don’t see how we can make a decision that says they should get a raise, because their job has not changed from two years ago. It’s still the same,” commission member Patrick Pavey said.
The 1 percent annual increases will mean Gov. Jay Inslee’s annual salary will increase from $173,617 to $177,107 between now and September 2018, while Lt. Gov. Cyrus Habib’s annual salary will increase from $101,889 to $103,937 during the same period.
Also receiving 1 percent raises each of the next two years: Attorney General Bob Ferguson, Insurance Commissioner Mike Kreidler, Secretary of State Kim Wyman, state Superintendent of Public Instruction Chris Reykdal and state Auditor Pat McCarthy.
A few elected officials will receive higher raises.
Public Lands Commissioner Hilary Franz will get a 2 percent raise each of the next two years. Commission members said her job — which involves coordinating wildfire-fighting efforts throughout the state — merited a higher increase due to the amount of state lands she has to manage, as well as how climate change is increasing the severity of the state’s wildfire season.
Commission members also decided to give a higher raise to state Treasurer Duane Davidson, who they said shoulders an especially high amount of responsibility for his annual salary of $140,438. The commission voted to increase Davidson’s pay by 2 percent this year and 1 percent next year, bringing his annual salary to $144,679 by September 2018.
Members of the state’s judicial branch will also get a little more money than other statewide elected officials. Judges serving on the Supreme Court, the state’s appellate courts, district courts and superior courts will get a 2 percent salary increase this year and another 2 percent raise in 2018, which commission members said would bring them closer to making what federal court judges make.
The salary commission meets every two years to set salaries for the state’s public officials. The 17-member board consists of 10 citizens who are selected randomly from the state’s voter rolls, while legislative leaders pick the remaining seven citizen members.
The last time the commission approved raises for elected officials was two years ago, and they were much higher. In 2015, the commission gave legislators raises of 11 percent over two years to make up for not increasing their salaries since 2008. Raises for other elected officials ranged from more than 4 percent for the governor, attorney general, secretary of state and auditor to more than 12 percent for the state treasurer.
State lawmakers’ expected raises
Sept. 1, 2017
Sept. 1, 2018
Senate Majority Leader
House Minority Leader
Senate Minority Leader
Secretary of State
Superintendent of Public Instruction
Commissioner of Public Lands
Supreme Court Chief Justice
Supreme Court Justices
Court of Appeals Judges
Superior Court Judges
District Court Judges


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Anecdotal Reports Distributed
Students will be receiving anecdotal reports today from their teachers.
The anecdotal report is meant to provide an early indication of a students achievement in a class. Anecdotal reports do not indicate a precise grade, but rather a range or level.
Now is the time to make any changes that may be required as indicated on the anecdotal report.
Parent-teacher interviews will take place on Wednesday, March 8th. These interviews are a great opportunity to discuss the anecdotal report with the classroom teacher.


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Turkey tail mushrooms are a type of medicinal mushroom that have been used for centuries to support immune health. They are also known for their anti-inflammatory and antioxidant properties. In recent years, there has been growing interest in the use of turkey tail mushrooms for dogs.
There are a number of turkey tail mushroom supplements available for dogs. When choosing a supplement, it is important to look for one that is high quality and made with pure, organic ingredients. You should also consider the dosage and the form of the supplement (capsules, powder, etc.).
Here are some of the best turkey tail mushroom supplements for dogs:
- Mushroom Matrix Canine Organic Mushroom Powder Turkey Tail Immune Support and Holistic Defense Supplement: This supplement is made with pure organic turkey tail mushroom powder and is recommended by veterinarians. It is also gluten-free and vegan.
- NaturVet Mushroom Max Advanced Immune Support Dog Supplement: This supplement contains a blend of mushrooms, including turkey tail, shiitake, and reishi. It is also formulated with vitamins and minerals to support overall health.
- Honest Paws Dog Digestive and Immunity Booster – Turkey Tail Mushroom Blend: This supplement is a blend of turkey tail mushrooms, shiitake mushrooms, and maitake mushrooms. It is also free of fillers and additives.
- Four Sigmatic Mushroom Blend Mix: This supplement is a blend of five different mushrooms, including turkey tail. It is made with a hot water extraction process that preserves the nutrients in the mushrooms.
- Erbology Organic Turkey Tail Mushroom Powder: This supplement is made with pure organic turkey tail mushroom powder and is certified vegan and gluten-free.
No matter which turkey tail mushroom supplement you choose, it is important to start with a low dosage and increase it gradually as needed. You should also talk to your veterinarian before giving your dog any new supplement.
Here are some of the benefits of giving your dog a turkey tail mushroom supplement:
- Supports immune health
- Reduces inflammation
- Boosts energy levels
- Improves cognitive function
- Promotes skin and coat health
- May help fight cancer
If you are looking for a natural way to support your dog’s health, a turkey tail mushroom supplement is a good option to consider. Talk to your veterinarian to find the right supplement for your dog’s individual needs.
Here are some additional things to keep in mind when choosing a turkey tail mushroom supplement for dogs:
- The source of the mushrooms: It is important to choose a supplement that uses mushrooms that have been grown in a safe and sustainable manner.
- The extraction method: The extraction method used to make the supplement can affect the bioavailability of the nutrients in the mushrooms.
- The dosage: The recommended dosage for dogs will vary depending on the product.
- The form of the supplement: Turkey tail mushroom supplements are available in capsules, powders, and liquids. The form that you choose will depend on your dog’s preference.
By following these tips, you can choose the best turkey tail mushroom supplement for your dog’s health.

domain: biology


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🎃 🍂 Looking for Halloween & Fall Events? 🍂 🎃
Check out our Halloween & Fall Happenings featuring pumpkin patches, fall festivals, trunk-or-treats, and more!
Pippin – Selma
October 14 @ 7:30 pm$16 – $25
Heir to Frankish throne, the young prince Pippin is in search of the secret of true happiness. Watch has he find that happiness lies in the extraordinary moments of life. Tickets: $16–$25. 7:30 p.m. Selma Arts Center, 1935 High Street, Selma. 891-2238
Want to submit your event to this calendar? Email us at firstname.lastname@example.org!

domain: artistic


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Hepatic damage during transarterial chemoembolization (TACE) is a critical complication in patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). Apart from its role in preventing HBV reactivation, there is some evidence for the benefits of preemptive antiviral therapy in TACE. This study evaluated the effect of preemptive antiviral therapy on acute hepatic deterioration following TACE.
This retrospective observational study included a prospectively collected cohort of 108 patients with HBV-related HCC who underwent TACE between January 2007 and January 2013. Acute hepatic deterioration following TACE was evaluated. Treatment-related hepatic decompensation was defined as newly developed encephalopathy, ascites, variceal bleeding, elevation of the bilirubin level, prolongation of prothrombin time, or elevation of the Child-Pugh score by ≥2 within 2 weeks following TACE. Univariate and multivariate analyses were conducted to identify factors influencing treatment-related decompensation. Preemptive antiviral therapy involves directing prophylaxis only toward high-risk chronic hepatitis B patients in an attempt to prevent the progression of liver disease. We regarded at least 6 months as a significant duration of preemptive antiviral treatment before diagnosis of HCC.
Of the 108 patients, 30 (27.8%) patients received preemptive antiviral therapy. Treatment-related decompensation was observed in 25 (23.1%) patients during the follow-up period. Treatment-related decompensation following TACE was observed more frequently in the nonpreemptive group than in the preemptive group (29.5% vs. 6.7%, P=0.008). In the multivariate analysis, higher serum total bilirubin (Hazard ratio [HR] =3.425, P=0.013), hypoalbuminemia (HR=3.990, P=0.015), and absence of antiviral therapy (HR=7.597, P=0.006) were significantly associated with treatment-related hepatic decompensation.
Our findings suggest that preemptive antiviral therapy significantly reduces the risk of acute hepatic deterioration. Preventing hepatic deterioration during TACE by applying such a preemptive approach may facilitate the continuation of anticancer therapy and thus improve long-term outcomes.
Hepatocellular carcinoma (HCC) is the fifth most common cancer in the world and the most common primary liver cancer . There are a variety of therapies for treatment of HCC; among them, transarterial chemoembolization (TACE) is one of the most commonly used treatment modalities . TACE induces ischemic tumor necrosis by obstruction of hepatic artery blood flow and exerts an anticancer effect via chemotherapeutic agents such as adriamycin or cisplatin mixed with Lipiodol. In the American Association for the Study of Liver Diseases (AASLD) guidelines for the management of HCC, TACE is recommended for patients with intermediate-stage HCC according to the Barcelona Clinic Liver Cancer (BCLC) staging system, because TACE was found to improve survival compared with the best supportive care in patients with unresectable HCC [3-5]. Although TACE is the established standard of care only for intermediate-stage HCC, in recent years, TACE has been used widely even in treatment of advanced-stage HCC [6-9]. The most frequent side effects of TACE are fever, nausea, and abdominal pain, and these side effects are self-limiting in the majority of patients. However, acute deterioration of hepatic function following TACE is a potentially life-threatening complication that occasionally interferes with continuation of TACE in patients with HCC . Although TACE has marked direct antitumor effects, it can also result in more complications than conservative management, because the ischemic damage caused by TACE can influence not only tumor tissue but non-tumorous liver tissue.
Antiviral therapy against hepatitis B virus (HBV) is known to reduce the incidence of hepatic decompensation and delay clinical progression in patients with advanced fibrosis or cirrhosis . In particular, entecavir, one of the nucleot(s)ide analogues, is a potent inhibitor of HBV replication. It is known that preemptive antiviral therapy prevents the reactivation of HBV in patients undergoing TACE [12-14]. Apart from its role in preventing HBV reactivation, there are limited data on the benefits of preemptive antiviral therapy in deterioration of hepatic function related to TACE. This study aimed to evaluate the effect of preemptive antiviral therapy with entecavir on acute deterioration of hepatic function following TACE.
MATERIAL AND METHODS
This is a retrospective observational study of 108 patients in a prospectively collected cohort with HBV-related HCC who underwent TACE at the Catholic university of Korea Incheon St. Mary’s hospital between January 2007 and January 2013 (Fig. 1). Primary HCC was diagnosed in 561 patients in our institution. Patients who met the following criteria were entered into the study: age ≥ 18 years; hepatitis B surface antigen positive for at least 6 months; Child-Pugh Class A or B status; Barcelona Clinic Liver Cancer stage 0, A, or B HCC; treated with TACE; and antiviral therapy using entecavir 0.5 mg or no antiviral therapy. Patients were excluded for the following reasons: the presence of other liver diseases, including chronic hepatitis C, alcoholic liver disease, or autoimmune hepatitis (n=199); Child-Pugh class C status (n=43); BCLC stage C or D (n=137); other treatment for HCC including surgery, radiofrequency ablation, percutaneous ethanol injection, liver transplantation, or radiotherapy (n=50); mutation of HBV (n=3); or other antiviral therapy (n=21). Therefore, the study cohort consisted of 108 patients treated with TACE for HBV-related BCLC stage 0-B HCC, of whom 30 were given entecavir 0.5 mg prior to TACE. The diagnosis of HCC was done on the basis of the AASLD practice guidelines . The initiation of antiviral therapy was generally based on the Korean Association for the Study of the Liver guidelines  and the Korean national insurance policy: HBV DNA≥2,000 IU/mL and serum aminotransferase level above upper limit normal. We regarded at least 6 months as a significant duration of preemptive antiviral treatment before diagnosis of HCC. This study was approved by the local ethical committee and Institutional Review Board of the Catholic University of Korea.
TACE procedure and follow-up
TACE was performed by injection of doxorubicin hydrochloride (50 mg/session) and iodized oil (Lipiodol Ultra Fluid; Guerbet, France). After the first TACE session, follow-up TACE sessions were performed every 2 months until CT scans suggested complete tumor remission and TACE showed no more hypervascular staining of the tumor. After TACE, liver and renal function tests, including albumin, total bilirubin, aspartate transaminase, alanine transaminase, prothrombin time-international normalized ratio, and creatinine levels were monitored at least every 3 days. CT scans were performed every 2 months to evaluate treatment response and progression of liver cirrhosis.
Assessment of outcomes
The primary endpoint was development of treatment-related deterioration of hepatic function after TACE for HBV-related HCC. Secondary endpoints included development of HBV reactivation, hepatitis, severe hepatitis, or ≥grade 3 common toxicity criteria of hepatic measures, including alanine aminotransferase, aspartate aminotransferase, and blood bilirubin. Acute deterioration of hepatic function was defined as newly developed encephalopathy, ascites, variceal bleeding, hepatorenal syndrome, a bilirubin level more than 2.5 times the upper normal limit, prolongation of prothrombin time by more than 3 seconds, or an elevation of the Child-Pugh score (≥2) within 2 weeks following TACE [10,16,17]. HBV reactivation was defined as a greater than 10-fold increase in serum HBV DNA from nadir during antiviral therapy. Hepatitis and severe hepatitis were defined as AST or ALT scores that were more than 2 times and 5 times the upper normal limits, respectively. Hepatic common toxicity criteria were based upon the common terminology criteria (CTC) for adverse events version 4.0 .
Categorical variables are described as frequencies and percentages. Continuous variables are presented as means ± standard deviations (SD) and medians with interquartile ranges for parametric and non-parametric variables, respectively. Baseline characteristics were analyzed using the χ2 test for categorical variables and Student’s t test for continuous variables. Cox proportional hazards models were used to assess the risk factors for treatment-related decompensation after TACE. The variables used for multivariate analysis were selected on the basis of statistical significance in the univariate analysis (P<0.10). Multivariate analysis was performed using a forward conditional stepwise procedure to exclude confounding variables. Kaplan-Meier curves and a log-rank test were used to estimate the cumulative incidence of treatment-related decompensation. A P-value less than 0.05 on a two-tailed test was regarded as statistically significant. Statistical analyses were carried out using the Statistical Package for the Social Sciences version 16.0 for Windows (SPSS, Inc., Chicago, IL, USA).
Characteristics of the study population
The clinical characteristics of the patients at the time of diagnosis of HCC are shown in Table 1. The study population was comprised of 108 patients who met the eligibility criteria, 30 of whom received antiviral therapy (preemptive group; entecavir 0.5mg) and 78 of whom did not receive antiviral therapy (non-preemptive group) prior to TACE. The mean age of the 108 patients was 57.6 years (SD: 9.6 years), and 84 (77.8%) were male. In baseline liver function, 84 patients (77.8%) were Child-Pugh class A and 24 patients (22.2%) were class B. Regarding tumor characteristics, 23 patients (21.3%) were BCLC stage 0, 45 patients (41.7%) were stage A, and 40 patients (37.0%) were stage B. There were no significant differences in age, gender, HBeAg positivity, HBV DNA levels, total bilirubin, ALT, creatinine, α-fetoprotein, total tumor size, Child-Pugh class, and BCLC stage of HCC between the two groups. However, patients in the preemptive group had significantly lower serum albumin levels (3.6 vs. 3.8 mg/dL, P=0.036) and platelet counts (102 vs. 136 ×103/mm3, P=0.008), and higher levels of PT INR (1.23 vs. 1.13, P=0.008).
Incidence of acute hepatic deterioration after TACE
Among all 108 patients, 25 (23.1%) suffered from treatment-related decompensation. The rate of decompensation was significantly lower in the preemptive group than in the non-preemptive group (6.7% vs. 29.5%, P=0.008). HBV reactivation occurred more frequently in the non-preemptive group than in the preemptive group (60.3% vs. 0.0%, P<0.001). Hepatic CTC for adverse events grade 3 or 4, hepatitis, and severe-grade hepatitis following TACE developed in 35 (32.4%), 59 (54.6%), and 27 (25.0%) patients, respectively. However, there were no significant differences in the hepatic CTC for adverse events grade 3 or 4 (P=0.245), hepatitis (P=0.317), and severe-grade hepatitis (P=0.485) following TACE between the preemptive group and the non-preemptive group. Although the results revealed no significant statistical differences, the incidences of hepatic adverse events, hepatitis, and severe-grade hepatitis were lower in the preemptive group than in the non-preemptive group (Fig. 2).
Risk factors for treatment-related decompensation
Treatment-related decompensation was observed in 25 patients (23.1%); 3 patients developed ascites, 1 developed hepatic encephalopathy, 7 demonstrated an increase in bilirubin levels, and 21 demonstrated an increase in Child-Pugh score. Univariate analysis was performed to screen the risk factors for treatment-related decompensation (Table 2). The predictive factors included in the univariate analysis were gender, age, HBeAg positivity, HBV DNA levels, Child-Pugh class, total bilirubin, ALT, albumin, creatinine, platelet counts, PT INR, alpha-fetoprotein (AFP) levels, total tumor size, BCLC stage of HCC, and preemptive antiviral therapy. Univariate analysis revealed that treatment-related decompensation was significantly associated with higher levels of total bilirubin (≥0.8 mg/dL, P=0.003), lower levels of albumin (≤3.8 g/dL, P=0.003), and non-antiviral therapy (P=0.040). In multivariate analysis, higher levels of total bilirubin (≥0.8 mg/dL; hazard ratio (HR), 3.425; 95% CI, 1.294-9.066; P=0.013), lower levels of albumin (≤3.8 g/dL; HR, 3.990; 95% CI, 1.307-12.182; P=0.015), and non-antiviral therapy (HR 7.597; 95% CI, 1.768-32.645; P=0.006) were the statistically significant factors predictive of treatment-related decompensation (Table 3). The cumulative incidence of treatment-related decompensation was significantly higher for patients with higher levels of total bilirubin (≥0.8 mg/dL, P=0.001) or lower levels of albumin (≤3.8 g/dL, P=0.001) (Fig. 3A, 3B). Patients who did not receive preemptive antiviral therapy had a higher risk of developing treatment-related decompensation than those who were given preemptive antiviral therapy (P=0.024) (Fig. 3C).
Although TACE is one of the most effective treatments for HCC, repeated TACE can affect remnant hepatic function and interfere with the ability to continue treatment in patients with HCC. Furthermore, patients with HBV-related HCC can be affected not only by repeated TACE but also by hepatitis B virus replication. This is because TACE is usually performed with administration of chemotherapeutic agents such as adriamycin or cisplatin. A prospective study showed that preemptive antiviral therapy in patients with HBV-related HCC can reduce the incidence of hepatitis due to HBV reactivation during TACE .
This study was conducted to evaluate the effect of preemptive antiviral therapy with entecavir on acute deterioration of hepatic function following TACE. One hundred eight patients with HBV-related HCC treated with TACE were enrolled in this study. A comparison was made between 38 patients who received preemptive antiviral therapy with entecavir (0.5mg/day) and 70 patients who did not in terms of development of acute hepatic deterioration following TACE. This study is distinct from earlier studies in that all patients in the preemptive group received entecavir only, while patients in other studies received various antiviral agents, such as lamivudine, adefovir, dipivoxil, and telbivudine [19,20].
In a retrospective study of 49 patients, Kuzuya et al. compared changes in remnant liver function after curative treatment for HCC according to whether patients received antiviral treatment or not. Remnant hepatic function was significantly better at the time of HCC recurrence in patients who received antiviral therapy . In addition to treating HCC, nucleos(t)ide analogues can markedly inhibit acute deterioration of hepatic function after TACE. Lao et al.  found that HBV reactivation after TACE was significantly reduced in patients who received antiviral therapy, and the rate of deterioration of liver function was higher in the HBV reactivation group than in the non-reactivation group. Another study showed that antiviral therapy with lamivudine can improve hepatic function and produce better outcomes after liver resection . In the present study, the cumulative incidence of treatment-related decompensation was found to be 23.1% in all patients. In our study population, the patients in the preemptive group started out with higher levels of serum HBV DNA and significantly worse markers of hepatic function, such as lower levels of albumin, lower platelet counts, and prolonged PT INR. Nevertheless, patients who received preemptive antiviral therapy showed a significantly lower incidence of TACE-related decompensation compared with the non-preemptive group (6.7% vs. 29.5%, P=0.008).
Other studies proposed higher AFP, larger tumor size, and increased ALT levels as factors that influenced the development of complications or deterioration after TACE [10,19,23,24]. However, in the present study, AFP, total tumor size, BCLC stage of HCC, and serum ALT levels had no significant effect on acute deterioration of liver function following TACE. Instead, higher serum total bilirubin and lower serum albumin levels significantly influenced treatment-related hepatic decompensation, as did not receiving preemptive antiviral therapy (Table 3).
We also analyzed the incidence of acute hepatic deterioration following TACE as well as the treatment-related decompensation. The incidence of acute hepatic deterioration, including hepatitis, severe hepatitis, and hepatic adverse events of grades 3 or 4 was greater in the non-preemptive group (57.7%, 26.9%, and 35.9%, respectively) than in the preemptive group (46.7%, 20.0%, and 23.3%), although the difference was not statistically significant (P=0.389, P=0.621, and P=0.256). The lack of statistical significance might be due to the small number of patients in the preemptive group rather than to a lack of effect of preemptive antiviral therapy.
The present study has several limitations. First, it was not a randomized controlled study. The study also lacked measures of long-term outcomes of HBV-related HCC treated with TACE. However, it is a post-hoc analysis from a database collected in a prospective manner. All patients received only TACE with a fixed dose of doxorubicin using the same technique in a single center, and patients in the preemptive group received entecavir only. The nature of this study population represents, therefore, a homogeneous and indicates that confounding factors behind management were significantly minimized. Reduction with antivirals in acute hepatic deterioration following TACE is likely to influence long-term clinical course. Future studies with larger numbers of patients and longer follow-up periods are necessary to further elucidate these findings.
In conclusion, our results demonstrated that preemptive antiviral therapy significantly reduces the risk of acute deterioration in hepatic function following TACE. Thus, preemptive antiviral therapy should be administered to patients undergoing TACE. Prevention of hepatic deterioration during TACE with such a preemptive approach may facilitate continuing anti-cancer therapy and thus potentially improve long-term outcomes.
The authors thank Dr. Won Sohn for his insightful and valuable comments during the preparation of this manuscript.
Funding support: This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (NRF-2016R1D-1A1B03930457).
The χ2 test for categorical variables and Student’s t test for continuous variables. Data are presented as the mean±standard deviation, median (range in parentheses) or number of patients (percentages in parentheses).
HBeAg, hepatitis B envelope antigen; HBV DNA, hepatitis B virus deoxyribonucleic acid; ALT, alanine aminotransferase; PT INR, prothrombin time international normalized ratio; AFP, alpha-fetoprotein; BCLC, Barcelona Clinic Liver Cancer.
Cox proportional hazards models.
HR, hazard ratio; CI, confidence interval; HBeAg, hepatitis B envelope antigen; HBV DNA, hepatitis B virus deoxyribonucleic acid; ALT, alanine aminotransferase; PT INR, prothrombin time international normalized ratio; AFP, alpha-fetoprotein; BCLC, Barcelona Clinic Liver Cancer.
American Association for the Study of Liver Diseases
Barcelona Clinic Liver Cancer
common terminology criteria
hepatitis B virus
hepatitis B envelope antigen
2. Ikai I, Arii S, Ichida T, Okita K, Omata M, Kojiro M, et al. Report of the 16th follow-up survey of primary liver cancer. Hepatol Res 2005;32:163-172.
3. Bruix J, Sherman M. Management of hepatocellular carcinoma: an update. Hepatology 2011;53:1020-1022.
4. Lo CM, Ngan H, Tso WK, Liu CL, Lam CM, Poon RT, et al. Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma. Hepatology 2002;35:1164-1171.
5. Llovet JM, Real MI, Montaña X, Planas R, Coll S, Aponte J, et al. Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomised controlled trial. Lancet 2002;359:1734-1739.
6. Chung GE, Lee JH, Kim HY, Hwang SY, Kim JS, Chung JW, et al. Transarterial chemoembolization can be safely performed in patients with hepatocellular carcinoma invading the main portal vein and may improve the overall survival. Radiology 2011;258:627-634.
7. Luo J, Guo RP, Lai EC, Zhang YJ, Lau WY, Chen MS, et al. Transarterial chemoembolization for unresectable hepatocellular carcinoma with portal vein tumor thrombosis: a prospective comparative study. Ann Surg Oncol 2011;18:413-420.
8. Leng JJ, Xu YZ, Dong JH. Efficacy of transarterial chemoembolization for hepatocellular carcinoma with portal vein thrombosis: a meta-analysis. ANZ J Surg 2016;86:816-820.
9. Lee JM, Jang BK, Lee YJ, Choi WY, Choi SM, Chung WJ, et al. Survival outcomes of hepatic resection compared with transarterial chemoembolization or sorafenib for hepatocellular carcinoma with portal vein tumor thrombosis. Clin Mol Hepatol 2016;22:160-167.
10. Chan AO, Yuen MF, Hui CK, Tso WK, Lai CL. A prospective study regarding the complications of transcatheter intraarterial lipiodol chemoembolization in patients with hepatocellular carcinoma. Cancer 2002;94:1747-1752.
11. Liaw YF, Sung JJ, Chow WC, Farrell G, Lee CZ, Yuen H, et al. Lamivudine for patients with chronic hepatitis B and advanced liver disease. N Engl J Med 2004;351:1521-1531.
12. Jang JW, Choi JY, Bae SH, Yoon SK, Chang UI, Kim CW, et al. A randomized controlled study of preemptive lamivudine in patients receiving transarterial chemo-lipiodolization. Hepatology 2006;43:233-240.
13. Sung PS, Bae SH, Jang JW, Song do S, Kim HY, Yoo SH, et al. Differences in the patterns and outcomes of enhanced viral replication between hepatitis C virus and hepatitis B virus in patients with hepatocellular carcinoma during transarterial chemolipiodolization. Korean J Hepatol 2011;17:299-306.
14. Jang JW, Kim YW, Lee SW, Kwon JH, Nam SW, Bae SH, et al. Reactivation of hepatitis B virus in HBsAg-negative patients with hepatocellular carcinoma. PLoS One 2015;10:e0122041.
15. KASL clinical practice guidelines: management of chronic hepatitis B. Clin Mol Hepatol 2016;22:18-75.
16. Trinchet JC, Bourcier V, Chaffaut C, Ait Ahmed M, Allam S, Marcellin P, et al. Complications and competing risks of death in compensated viral cirrhosis (ANRS CO12 CirVir prospective cohort). Hepatology 2015;62:737-750.
17. Huang YS, Chiang JH, Wu JC, Chang FY, Lee SD. Risk of hepatic failure after transcatheter arterial chemoembolization for hepatocellular carcinoma: predictive value of the monoethylglycinexylidide test. Am J Gastroenterol 2002;97:1223-1227.
18. U.S. Department of Health and Human services. Common terminology criteria for acverse events (CTCAE). In: National Institutes of Health, ed. National Cancer Institute, Vol. 4.03. 2010.
19. Lao XM, Luo G, Ye LT, Luo C, Shi M, Wang D, et al. Effects of antiviral therapy on hepatitis B virus reactivation and liver function after resection or chemoembolization for hepatocellular carcinoma. Liver Int 2013;33:595-604.
20. Toyoda H, Kumada T, Tada T, Sone Y, Fujimori M. Transarterial chemoembolization for hepatitis B virus-associated hepatocellular carcinoma: improved survival after concomitant treatment with nucleoside analogues. J Vasc Interv Radiol 2012;23:317-322.
21. Kuzuya T, Katano Y, Kumada T, Toyoda H, Nakano I, Hirooka Y, et al. Efficacy of antiviral therapy with lamivudine after initial treatment for hepatitis B virus-related hepatocellular carcinoma. J Gastroenterol Hepatol 2007;22:1929-1935.
22. Li N, Lai EC, Shi J, Guo WX, Xue J, Huang B, et al. A comparative study of antiviral therapy after resection of hepatocellular carcinoma in the immune-active phase of hepatitis B virus infection. Ann Surg Oncol 2010;17:179-185.
23. Kohla MA, Abu Zeid MI, Al-Warraky M, Taha H, Gish RG. Predictors of hepatic decompensation after TACE for hepatocellular carcinoma. BMJ Open Gastroenterol 2015;2:e000032.
24. Siriwardana RC, Niriella MA, Dassanayake AS, Liyanage CA, Upasena A, Sirigampala C, et al. Factors affecting post-embolization fever and liver failure after trans-arterial chemo-embolization in a cohort without background infective hepatitis- a prospective analysis. BMC Gastroenterol 2015;15:96.

domain: health


text:
A Thai graffiti artist says he is now facing harassment from security officials over anti-government cartoons he has been drawing to draw attention to the missing dissident Wanchalearm Satsakit.
The artist, known by his pen name Headache Stencil, said that security officials had been following him in Bangkok and plainclothes officers had visited his condominium.
When he called the police station to voice his complaint, the police told him that the officers there were to monitor his security and safety.
The case captured public attention and the hashtag #SaveHeadacheStencil was trending on Twitter for the past two days.
“The important thing about Headache Stencil is that this is intimidation towards a dissenter,” said Sunai Phasuk of Human Rights Watch. “He is quite well known in society as being a graffiti artist who criticizes the government and authority.”
“The police were not transparent in the way that they approached him, they did not state what they were doing and would not identify themselves which is concerning,” Sunai told Thai Enquirer.
“We have contact with Headache Stencil and he is concerned he is going be like another Wanchalearm.”
Wanchalearm was abducted from his apartment in Cambodia last month by unknown actors.

domain: politics


text:
December 27, 2018 4:59 PM ET
Judiciary premieres new song
is streaming a new track from their upcoming debut LP,
(due out January 25). The song is titled "Social Crusade" and can be heard now via
For The Children 2021 lineup announced
United Blood Fest 2020 lineup takes shape
LDB Fest 2020 lineup announced
Gatecreeper, Exhumed co-headlining fall tour
Knocked Loose, Eternal Sleep, Judiciary tour dates
Top News Tidbits This Week
Lambgoat is looking for reviewers
Madball has premiered a new track.
Video: Sworn In play Italian restaurant in Buffalo, NY
Impending Doom is streaming a new song.
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more news tidbits


The Hurst exponent as an indicator of the behaviour of a model monopile in an ocean wave testing basin
IOP Publishing Ltd
With the importance of renewable energy well-established worldwide, and targets of such energy quantified in many cases, there exists a considerable interest in the assessment of wind and wave devices. While the individual components of these devices are often relatively well understood and the aspects of energy generation well researched, there seems to be a gap in the understanding of these devices as a whole and especially in the field of their dynamic responses under operational conditions. The mathematical modelling and estimation of their dynamic responses are more evolved but research directed towards testing of these devices still requires significant attention. Model-free indicators of the dynamic responses of these devices are important since it reflects the as-deployed behaviour of the devices when the exposure conditions are scaled reasonably correctly, along with the structural dimensions. This paper demonstrates how the Hurst exponent of the dynamic responses of a monopile exposed to different exposure conditions in an ocean wave basin can be used as a model-free indicator of various responses. The scaled model is exposed to Froude scaled waves and tested under different exposure conditions. The analysis and interpretation is carried out in a model-free and output-only environment, with only some preliminary ideas regarding the input of the system. The analysis indicates how the Hurst exponent can be an interesting descriptor to compare and contrast various scenarios of dynamic response conditions.
Offshore structure , Tank testing , Monopile foundations
Pakrashi, V., O'Shea, R., Jaksic, V. and Murphy, J. (2015) 'The Hurst exponent as an indicator of the behaviour of a model monopile in an ocean wave testing basin', Journal of Physics: Conference Series, 628 (1), 012057. doi: 10.1088/1742-6596/628/1/012057
© 2015, the Authors. Published under licence in Journal of Physics: Conference Series by IOP Publishing Ltd. Content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.


text:
I am about a month (i think) and have cramping (like menstrual cramps) and sometimes random shooting pains on my right side. My back is a bit sore too but not as much as the cramps. Is this normal? I am going to see a dcotor in the morning.
Thank you, Dechen
I have cramps and back pains too. I am 5w2d, but I do not have any kind of "shooting" pain in my sides. I would say the cramps and back pain without spotting are probably normal. I know I had them with my last pregnancy but I had just had 2 m/c so I was concerned over everything. I am concerned this time around too, but trying not to worry. So...I would definatley get the pain in your side checked and let the doctor know about the other concerns, and if you don't mind, please put an update on here tomorrow about what the dr. says. I will check this post off and on tomorrow. I do appreciate it.
Sticky Baby Dust to you, I hope we both have a healthy nine months!
First month of clomid, cramp like pains, but higher near belly button, I was just wondering on day 22 at my dctrs appt they took my progest. level and what should it be if I am pregnant or to just make sure that things are at least going in the right direction. I know there is such a varience of levels during cycle and pregnancy but can anyone help let me know what they may be on day 22 even if it's to let me know that I am not pregnant but helping things in a normal cycle. Thanks and good luck to everyone my prayers are with you all in this situation.
It could be nothing.....a lot of women have what they think are cramps but are really ligaments stretching.
I've had both a normal pregnancy and m/c's as well (3 m/c this year to be exact) and to me and for me there was a distinct difference between the cramps I had when I had my daughter and my m/c cramps.
My 2 m/c this year were cramps, menstrual like cramps with lower back pain for 3 days before I started spotting...Spotting lasted a day and then it turned to bleeding..really heavy bleeding...blood was just pouring out and I knew there was no going back. MY last m/c I had no symptoms of m/c but needed a d&e at 8.5 wks.
I seriously doubt that cramps mean m/c in your case...if they intensify or you start bleeding you will want the dr to do a u/s in a week or so.
The pain in your right side worries me...Not to scare you but I've heard of many ectopics on this page....
I'M PRAYING FOR YOU....GOD BE WITH YOU AND YOUR LITTLE ONE.
HI this is for busymom--i went to the doctor today and i guess it is fine. i had a T/V/U/S and they found the sack in the uterus so it is not ectopic. I asked the doc about the cramping and he saidit was absolutely normal. As for my back pain...ell my uterus in tilted all the way and I am assuming that back pain will be something I will have to befriend for the next months.
How was your appt. today? I hope all is well.
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domain: medical


text:
Florin Stan’s review published on Letterboxd:
When I was a ten-year-old brat I watched this movie on tv. The next day I found out from some of my classmates that they also watched it. We loved it so much that we copied the dueling competition from the movie. We would spend our breaks pretending to be gunfighters, holding duels, standing in front of each other and drawing our pens from our pockets. Whoever draw the pen faster would win. We each had our name inspired from the movie, like The Ace, The Boss, The Kid, Scars... well not Scars, no one wanted to be Scars! He was ugly and he stank! I was The Priest. I was pretty fast.
It has everything: wild gun spinning, lots of shooting, long back and forth stares, duels, rope shooting, saloon fights, saloon doors and crazy kills. One guy gets shot in the eye, flips in the air and lands on his face. Another one is shot in the head and we can see through the hole. The cast is incredible: Sharon Stone, Gene Hackman, Russell Crowe, Leonardo DiCaprio, Keith David, Lance Henriksen. Did I mention Sharon Stone? She's smoking! The style of film-making is through the roof, with crash zooms, dolly zooms, extreme close-ups, dutch angles, low angles and everything in between. Sam Raimi went haywire on this western, like he did on The Evil Dead films. It even has the obligatory flashback gradually revealed by the end, from which we learn the motives behind the main character.
Here's one of my favorite moments. The saloon owner is writing down people who enter the dueling competition. He asks "Anybody else?" and Sargeant Clay Cantrell played by Keith David answers "Sgt Cantrell". The saloon owner asks "How do you spell that?". The sargeant pauses, takes his time and lights his tobacco pipe, then replies: "Correctly!"
Now how can I not love it? Five gunshots out of five. Bam! Bam! Bam! Bam! and BAM!!! *blows smoke from top of the barrel, spins gun about eight or nine times and places gun in holster*


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Science says that dogs are one of the smartest animals in the world — and each week, there are more and more stories that act as proof of their intelligence. Take Stella, for example, who was taught by her 26-year-old speech pathologist owner to communicate with a custom soundboard and now knows around 30 words.
However, we’re not sure where this next story might land on the animal’s intelligence scale.
On Thursday, one Florida pup became the subject of a police pursuit after he was spotted doing doughnuts in a cul-de-sac in Port. St. Lucie. The black labrador, who was the only one in the grey sedan at the time, was captured on video in the front seat of the running car.
According to reports, the dog jumped in his owner’s running car, managed to put the vehicle in reverse and was spinning in backward circles for over an hour.
Neighbor Anne Sabol first thought the dog’s joyride was the result of a student driver.
“First I thought I saw somebody backing up but then they kept going and I’m like OK what are they doing,” she told reporters.
Local fire rescue and cops were able to stop the car when it slowed down after hitting a mailbox and trashcans on the street. The labrador jumped out after the cops opened the door and was unharmed.
See the entire moment unfold in the video above.
More to read:


„Seamless integration" - that's no simple buzzword but more and more an important aspect when it comes to installing additional components into the dashboard of a car.
If you intend to integrate our display remote control in the most unobtrusive way, then here's what you were desperately waiting for - the DIRECTOR CREATE edition.
Delivered without the metal housing this kit definitely requires comprehensive mounting skills. But for DIY experts who really know how to deal with their tools the dream of invisible installation is now within reach!
- 2.8“ / 7 cm touchscreen display and powerful ARM processor
- Easy handling of the main functions
- Volume control of all sources
- Volume control of the subwoofer
- Source selection
- Control of the HEC BT module (Bluetooth® Connect functions: pairing, reconnect, disconnect / Bluetooth® Control functions: track forward/back, play/pause)
- Switching between sound setups
- Memory locations for 20 additional sound setups
- Automatic dimming function of the display
- Display rotation adjustable to 180°
- USB Paththrough - to connect your computer to the DSP
- Compatible with all DSP products which are supported by DSP PC-Tool Version 3 and higher
- 17’ / 5.2 m connection cable included
1 x DIRECTOR circuit board with touchscreen
1 x Aluminum control knob
1 x Connection cable 5.2 m length
1 x USB cable
1 x Mounting screws
1 x Allen key
Note: This construction set requires comprehensive mounting skills to avoid damages to the touchscreen or circuit board during assembly.
|HELIX||DSP PRO (MK1/MK2)
P SIX DSP (MK1 / MK2)
V EIGHT DSP
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What are phytochemicals, where do you find them and do you actually need them?
Phytochemicals, commonly known as phytonutrients, are naturally occurring compounds found in plants that are associated with many health benefits. Although these compounds are not essential nutrients like vitamins and minerals, they can contribute to overall well-being and may have protective effects against certain diseases due to antioxidant and toxin removal properties.
Humans and Phytochemicals
Humans have known that plants contain special chemicals that improve health and prevent disease for more than 1000 years. In fact the exploration of phytochemicals has a history that dates back to ancient civilizations:
Ancient Civilizations: In the traditional medicine systems of ancient civilizations, such as Ayurveda in India and Traditional Chinese Medicine, plants were used for medicinal purposes. People observed the effects of various plant compounds on health and well-being, although the specific identification of phytochemicals was not yet established.
Middle Ages and Renaissance: During the Middle Ages and the Renaissance, herbalism became more organised and was a profession in its own right, as plant-based remedies were documented in herbal texts. However, the understanding of specific phytochemicals was still limited, with ineffective medicines being blamed on the evil doings of the taker.
18th and 19th Centuries: The isolation and identification of specific plant compounds began to advance in the 18th and 19th centuries. Chemists and scientists were developing equipment and methods for isolating active components from medicinal plants. For example, morphine was isolated from opium in the early 19th century.
20th Century: The 20th century marked a significant leap in the study of phytochemicals. Advances in analytical techniques, such as chromatography and spectroscopy, allowed scientists to identify and study compounds in greater detail. This led to the isolation and identification of many bioactive plant compounds, including alkaloids, flavonoids, and phenolic acids.
Nutrition and Health Research: In the latter half of the 20th century and into the 21st century, research on phytochemicals expanded, particularly in the context of nutrition and health. Studies started to investigate the potential health benefits of phytochemical-rich diets, including their role in preventing chronic diseases such as cancer and cardiovascular diseases.
Current Era: Today, phytochemical research continues to grow, with a focus on understanding the mechanisms of action of these chemicals and any potential therapeutic applications that they may have. The interest in plant-based diets and the health benefits associated with phytochemical-rich foods has led to increased awareness and research in this field. As scientific methods and technologies have advanced, our understanding of phytochemicals and their potential health benefits has deepened. Ongoing research continues to uncover new compounds and explore their diverse effects on human health.
There are thousands of different phytochemicals, and they can be classified into various categories by chemical structure, the plants that they are found in ore properties that they may have. These categories include:
Flavonoids: Found in fruits, vegetables, tea, and red wine. They have antioxidant properties and may help protect cells from damage.
Carotenoids: These include beta-carotene, lycopene, and lutein, found in colorful fruits and vegetables. Carotenoids have antioxidant properties and can be converted into vitamin A in the body.
Glucosinolates: Present in cruciferous vegetables like broccoli, cabbage, and Brussels sprouts. They are known for their potential anti-cancer properties.
Phenolic acids: Found in fruits, vegetables, and whole grains. They have antioxidant properties and may contribute to cardiovascular health.
Alkaloids: These include caffeine, nicotine, and morphine, and are found in various plant sources. Alkaloids can have stimulant or sedative effects on the human body.
Saponins: Present in legumes, whole grains, and some vegetables. They may have immune-boosting and cholesterol-lowering effects.
Terpenoids (or terpenes): Found in essential oils of many plants. They can have anti-inflammatory and antioxidant properties.
Phytochemicals are believed to contribute to the health-promoting properties of a diet rich in fruits, vegetables, whole grains, and other plant-based foods. Including a variety of colourful and nutrient-dense plant foods in your diet is a good way to ensure you get a range of phytochemicals with potential health benefits.


Executive Director, Pennsylvania Immigration and Citizenship Coalition
Posted by on May 21, 2012
Pennsylvania Immigration and Citizenship Coalition Seeks a Dynamic Executive Director
Position: PICC Executive Director
Applications Due: June 8, 2012
The Pennsylvania Immigration and Citizenship Coalition (PICC) a diverse statewide immigrant rights coalition seeks a highly motivated, skilled and committed individual who can lead PICC to realize its full potential. This is a unique opportunity to take a small, but important and effective immigrant rights organization to the next level of influence and impact. PICC is a diverse statewide coalition of 50 member organizations and numerous individuals that represents the needs of immigrants, migrants, refugees and other new Americans living in Pennsylvania to policy makers, public officials, and the general public. We seek to educate the public and develop support for fair policies that welcome and sustain immigrants. PICC’s programs include: advocacy on issues of health care, immigration reform, language access and law enforcement relations; training to build capacity among service providers and community leaders; civic engagement and citizenship promotion.
While the priority is to find a full time hire, a highly qualified person seeking part time opportunities will be considered.
Location: Philadelphia, PA
Position Status: Full time
Reports to: PICC’s Board of Directors
Position Description: The Executive Director is the Chief Executive and Financial Officer of PICC and shall be responsible for the oversight of all management and administrative functions of PICC at the direction of the Board. The Executive Director will oversee the areas of advocacy, policy analysis, public relations, development, management and administration in the organization. A full description of the job can be found on PICC’s website by clicking here.
Experience and Education: A minimum of five years of demonstrated leadership experience in a non-profit environment or related setting. A proven track record of coalition building is required. The applicant must possess knowledge and understanding of immigration issues and have experience working with multicultural and immigrant communities. Experience in building civic/voter engagement programs and advocacy campaigns is preferred. A post-graduate degree is preferred. Bi-lingual applicant with effective written and verbal communication skills in both languages is preferred.
To apply please submit:
Resume, cover letter, three references, and a relevant writing sample via email to: firstname.lastname@example.org by June 8, 2012.
The Pennsylvania Immigration and Citizenship Coalition is an equal opportunity employer.
- Program Coordinator, Intergenerational Center
- Family & Friends Program Coordinator, Temple Univ.
- Workforce Employment Specialist, College of Education
Stay Current in Philly's Higher Education and Nonprofit Sector
We compile a weekly email with local events, resources, national conferences, calls for proposals, grant, volunteer and job opportunities in the higher education and nonprofit sectors.


There are numerous ways to download songs for free, and one of the easiest is through an on-line portal. Songs Download All is one such portal. Its database of songs includes Indian pop and Hindi songs, and is extremely easy to navigate. All of its songs are available for download in high-quality audio and video. In addition to offering a large selection, Songs Download All also provides offline download options. To learn how to download songs for free, check out the article below.
The database of music at Songs Download All is regularly updated, so users can visit this website regularly to download the latest movies and music. This allows users to enjoy the highest quality of mp3 files. This makes it easier to listen to the music in the comfort of your own home. It also helps to keep track of your favorite music by genre. And if you have a taste for a particular genre, this website is an excellent choice.


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You can use SVG Morphing to do that. There are many libraries that offer that feature, one of them is (https://animejs.com/) [anime js]. - Source: Reddit / 3 months ago
There are a couple of directives you should learn about in svelte, specifically transition and animate. There are some convenient and simple to use transitions out of the box and you can also easily create your own custom transitions and animations. You can also have a look at svelte/motion. For most complex animation I use Anime with Svelte. - Source: Reddit / 3 months ago
I think you might be able to achieve this using anime.js. - Source: Reddit / 3 months ago
2 June 2021 - Fern.team - Wappalyzer tells me this site has been created using Webflow, which "empowers designers to build professional, custom websites in a completely visual canvas with no code". Webflow is a paid-for service, thus technically out of scope for the question, but the site animation is mainly video and gif images controlled by a scroll effect. Under the hood, the site is loading Anime.js which is... - Source: Reddit / 6 months ago
@okikio/animate is heavily inspired by animejs and animateplus, as such it uses very similar API's and formats. - Source: dev.to / 6 months ago
I used anime.js to get the spring effect for my animations. But the animation itself was built by me if that makes sense. Other than that I did all the styling by myself :D. - Source: Reddit / 6 months ago
Anime.js might be worth looking into if your comfortable writing a little code. Https://animejs.com/. - Source: Reddit / 8 months ago
Here's what appears to be the relevant function from their main.js file. Note that this site utilizes anime.js. - Source: Reddit / 9 months ago
Do you know an article comparing Anime.js to other products?
Suggest a link to a post with product alternatives.

domain: hobby


The company has thrown its weight behind the upcoming Metropolis Congress in Sydney by providing a way for delegates to virtually network and collaborate before, during and after the event.
Cisco hopes to get between 10 and 20 percent of the 800 anticipated delegates using its collaborative platform around the Congress.
It is also hoping that delegates will continue using the platform in their home countries.
This could possibly provide sales opportunities and also potentially impact ‘every aspect’ of urban design and planning, according to Martin Stewart-Weeks, director of public sector, Internet business solutions group at Cisco Systems Australia.
“Networking is one element of the mix you need to build a sustainable city,” Stewart-Weeks told iTNews.
“For Cisco, the city has become a significant arena in which to demonstrate the value of our technology and how network collaboration and communication tools contribute to better urban design, environmental management and economic sustainability.”
Routers, switches, wireless and WiMAX technologies, mesh and unified communications are all said to be technologies that have a strong play in the urban arena, according to Stewart-Weeks.
Cisco will also be looking closely at how urban planners and architects are able to use this technology in their roles worldwide.
The custom WebEx system is anticipated to be in a production environment by September.
Urban planners get virtual community
By Ry Crozier on Aug 13, 2008 1:18PM


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40 Tours Around The Sun (Live) Toto
Dear HIGHRESAUDIO Visitor,
due to territorial constraints and also different releases dates in each country you currently can`t purchase this album. We are updating our release dates twice a week. So, please feel free to check from time-to-time, if the album is available for your country.
We suggest, that you bookmark the album and use our Short List function.
Thank you for your understanding and patience.
Yours sincerely, HIGHRESAUDIO
- 1Intro Tape (Live)00:36
- 2Alone (Live)04:34
- 3Hold The Line (Live)04:00
- 4Lovers In The Night (Live)05:17
- 5Spanish Sea (Live)04:46
- 6I Will Remember (Live)07:01
- 7English Eyes (Live)07:19
- 8Jake To The Bone (Live)08:06
- 9Lea (Live)04:38
- 10Rosanna (Live)08:18
- 11Miss Sun (Live)03:45
- 12Georgy Porgy (Live)02:06
- 13Human Nature (Live)02:13
- 14Holyanna (Live)01:49
- 15No Love (Live)02:12
- 16Mushanga (Live)03:24
- 17Stop Loving You (Live)02:49
- 18Girl Goodbye (Live)06:40
- 19Angela (Live)05:23
- 20Lion (Live)06:45
- 21Dune (Desert Theme) (Live)06:03
- 22While My Guitar Gently Weeps (Live)06:22
- 23Stranger In Town (Live)04:35
- 24Make Believe (Live)04:30
- 25Africa (Live)12:36
- 26The Road Goes On (Live)04:08
Info for 40 Tours Around The Sun (Live)
When Hold The Line crashed into the charts all over the world in 1978 Toto had no idea how long their career would last. 40 years later Toto celebrate their career with this stunning concert at Amsterdam’s Ziggodome performing their monster hits Africa, Rosanna, Hold The Line, Stop Loving Youand many more. In addition 40 Tours Around The Sun features a Storytellers segment in which the band’s four key figures, David Paich, Steve Lukather, Steve Porcaro and Joseph Williams, plunder their back catalogue, describe the background behind their first demo and reveal the genesis of Michael Jackson’s Human Naturewritten by the band’s Steve Porcaro. In front of 17,000 fans this concert features songs from Toto’s first album to their latest release and includes rarely played gems such as the complex instrumental Jake To The Boneand the theme to David Lynch’s Dune.
This live performance was filmed and recorded in front of a sold-out crowd exceeding 18,000 fans on March 17, 2018 at the Ziggo Dome in Amsterdam. TOTO performed a wide range of songs, including hit singles, rarely performed live deep cuts, and two recently recorded tracks which appeared on their new Greatest Hits album (40 Trips Around The Sun).
TOTO will be busy in 2019. The band just returned from a standing room only run of Australia and New Zealand, and head to Japan (including a sold out show at Budokan in Tokyo) and Indonesia in February. This spring in to the Summer, they’ll stage a long tour of Europe, combining top billing festival appearances and headline dates, after which they’ll bring their “An Evening With” show to North America this Fall. The 40 Trips Around The Sun tour is the band’s most extensive run in years with many more announcements to come.
With over 40 years together and literally thousands of credits, including the biggest selling album of all time: Michael Jackson’s Thriller, and accolades to their names, TOTO remains one of the top selling touring and recording acts in the world. They are the benchmark by which many artists base their sound and production, and they continue to transcend the standards set by the entire music community, being simply synonymous with musical credibility. Their repertoire continues to be current via high profile usage on broadcast television. They are pop culture, and are one of the few 70’s bands that have endured the changing trends and styles to a career enjoy a multi-generational worldwide fan base.
Steve Lukather, vocals, guitars
David Paich, vocals, keyboards
Joe Williams, vocals
Steve Porcaro, keyboards
Shem von Schroeck, bass
Warren Ham, saxophone, vocals
Shannon Forrest, drums
Lenny Castro, percussion
No biography found.
This album contains no booklet.

domain: entertainment


04 Jul 2015
Bengaluru: Playing with poise and purpose, the senior Indian men's basketball team steamrolled past eastern neighbours Nepal and Bangladesh on the opening day of the 4th South Asian Basketball Association SABA Championship at the Kanteerava Indoor Stadium.
03 Jul 2015
Mumbai: The doctors affiliated to Maharashtra Association of Resident Doctors (MARD) today withdrew their strike following an assurance from the government that their demands would be fulfilled.
03 Jul 2015
New Delhi: Europe's Airbus Group and India's Mahindra Group have struck a deal to build helicopters jointly as they bid to win an expected wave of orders from the country's armed forces, the companies said in a statement on Friday.
02 Jul 2015
Srinagar: The government today said it sincerely wants to have friendly relations with all its neighbouring countries, including Pakistan, but Islamabad will also have to think about its approach.
30 Jun 2015
Santiago: Eduardo Vargas scored twice as Chile downed fierce rivals Peru 2-1 here to reach the Copa America final for the first time in nearly 30 years.
26 Jun 2015
Kathmandu: Three mild aftershocks were felt within three hours in different areas in Nepal, two months after the deadly tremor jolted the Himalayan nation and claimed nearly 9,000 lives.
09 Jun 2015
Kathmandu: Nepal's warring political parties have sealed a landmark 16-point deal to end years of deadlock over contentious issues of Constitution-drafting, agreeing to a Parliamentary system and eight provinces, in a rare show of unity following the devastating quakes.
25 Jun 2015
Kathmandu: India today pledged USD one billion in assistance to quake-ravaged Nepal for its massive reconstruction programme, asserting that it will strongly stand behind the Nepalese government which is seeking to 'wipe the tears' of every Nepali.
24 Jun 2015
Srinagar: A vehicle of Border Roads Organisation (BRO) was set on fire by a mob protesting against the killing of two militants and a civilian in Kulgam district of South Kashmir.
17 Jun 2015
Kathmandu: Four moderate earthquakes with magnitudes between 4 and 5.2 jolted Nepal early today, taking the total number of aftershocks to 320 after the devastating earthquake struck the country on April 25.


If you know of anyone selling a built 3 spd transmission (clutch packs, lock up torque converter, etc) message me.
Drive train is a SRT-4 turbo to a 31TH in an 88 GLH. Need lock up T.C. and parts for drag racing. Running 12 sec 1/4 mile on a 1 tire fire at 26lbs of boost.
I have a 1985 2.2T1 and 3 spd auto trans that came out of a dodge 600 appx 80Kmi. I was told everything was working when engine was pulled but I have no way to verify. Being sold as is. Looks like it has everything but fuel rail and ac compressor.I can get a $300 core charge for just the engine...
First off let me start by saying, I have read and re-read everything I could find on these trannies. Including Donovan's stuff and stuff from all around TD sites.
This is my first auto car. It's an 87' T1 with the 3-speed.
I recently installed a FWD-P stage-1 LM w/ 12lbs.
On top of my existing...


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Teens love to sleep. But how long and deep should their sleep be for good health? New studies in collaboration with investigators at the Division of Research find that poor sleep habits in adolescents may increase their risk for obesity and heart trouble down the line.
Author: Carla Lease
Don’t let the flu derail your festivities this year. Get vaccinated now to avoid a holiday season punctuated not by celebrations and gifts, but by coughs, sniffles, or worse.
Kaiser Permanente breaks new ground in telehealth with its Connect 2 Care Telepsychiatry Program.
Kaiser Permanente South Sacramento’s Emergency Department demonstrates innovation and efficiency in its approach to mental health care. As a designated…


The Boy’s Batesville Cross Country team traveled to South Ripley High School Thursday night to defend their county trophy against Milan, Jac-Cen-Del and South Ripley.The boys came away victorious while scoring 19 points. Jac-Cen-Del was second with 49 followed by South Ripley with 67 and Milan 111.Leading the way for Batesville was Caleb Moster, who was also 1st overall with a time of 17:43. Coming in 2nd for Batesville, and also second overall was Connor Bell. He also set a new personal record with a time of 17:55. Coming in 3rd for Batesville and, again, third overall, was Cole Nuhring with a time of 18:05.Also scoring for Batesville as their 4th runner and 5th overall was Chris Riffle who also set a personal record with his time of 18:46. Rounding out Batesville’s scoring runners was Clay Yeaton, who was 8th overall with a time of 19:14. Also running for Batesville was Garrett Yorn who came in 9th overall with a time of 19:20. Calvin Lehman who came in at 19:58 for the 11th overall spot followed him. Elliot Main came in behind him with a time of 20:34 earning him the 14th spot. Finally, Batesville had Jackson Wooldridge with his 18th overall spot and a new personal record of 20:50.Batesville’s boys also earned 6 of the 10 all county spots. Caleb Moster, Connor Bell, Cole Nuhring, Chris Riffle, Clay Yeaton, and Garrett Yorn earned these. These boys are starting to see all of the miles and hard work pay off as they keep improving their times and setting new personal records.Scores from County for the girls. Batesville 15, JCD 46, South Ripley 86, and Milan INC.They will compete again on Tuesday in the East Central Invitational.Courtesy of Bulldogs Coaches Ben Pierson and Lisa Gausman.


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Imaginative Writing: The Elements of Craft
Written by best-selling author Janet Burroway, Imaginative Writing -- an introduction to creative writing -- covers all four genres: creative nonfiction, fiction, poetry, and drama. Imaginative Writing discusses elements of craft common to all creative writing before delving into the individual genres. After an introduction, the next five chapters each investigate a specific element of craft -- Image, Voice, Character, Setting, and Story -- from a perspective that crosses all genres. Integrated readings from talented and renowned writers illustrate the chapter topics. Chapter 7 explores development and revision and serves as a bridge between the craft chapters and the genre chapters -- Creative Nonfiction, Fiction, Poetry, and Drama. This unique organization allows students to experiment with creative techniques shared by all genres before deciding which form best suits their imagination. Unique "Try-This" exercises help students develop writing skills, while "Working Toward a Draft" exercises encourage students to think ahead about the direction and possibilities of their work. - Publisher.
What people are saying - Write a review
LibraryThing ReviewUser Review - JosephJ - LibraryThing
Burroway makes some enlightening points and has some pretty good pieces as examples of good writing; but the book fails on so many levels. The first being that it is the third edition of a book that ... Read full review
Creative Nonfiction 144
Invitation to the Writer 1
38 other sections not shown


To deploy VMs that host Rhino TAS and your applications, use the VMBC tool to create a custom Rhino virtual appliance first.
The virtual appliance is a
zip file with the cloud service archive (CSAR) structure,
which is an open-standard archive structure for shipping product images together with relevant configuration metadata, necessary tools and scripts, and VM validation test data.
For each virtualization platform you plan to use, create a separate virtual appliance.
In Rhino VM automation, the major content of the virtual appliance is as follows:
A VM image file for the target virtualization platform. For example, a
.qcow2file for OpenStack.
rvtconfigtool for the VM type used.
The service configuration template files and relevant example files.
The test files for validating instantiated VMs.
The SIMPL server can process the virtual appliance CSAR file and deploy VMs from it.
For instructions on using VMBC to create custom Rhino virtual appliances, see VM Build Container User Guide.


This page explains the type of information that is collected by the Australian Criminal Intelligence Commission’s (ACIC) website, how such information is used, and under what circumstances and to whom it may be disclosed.
For more information about the types of information (including personal information) that the ACIC collects, including how it is is used, and under what circumstances and to whom it may be disclosed, please refer to our Information Handling Protocol:
If you have any privacy concerns, you should direct them to the ACIC Webmaster at email@example.com or by post:
Australian Criminal Intelligence Commission
GPO Box 1936
Canberra ACT 2601
Your email address
The ACIC will only record your email address in the event that you send a message by email. Your email address will not be added to any mailing lists without your prior consent.
When you visit the ACIC website, the internet servers make a record of your visit and log the following information for statistical purposes:
- server address
- top level domain name (for example .com, .gov, .au, .uk)
- date and time of the visit to the site
- pages accessed and documents downloaded
- previous site visited
- type of browser used.
No attempt will be made to identify users or their browsing activities except where a law enforcement agency may execute a warrant to inspect the Internet Service Provider's logs.
How the Australian Criminal Intelligence Commission collects information via this website
The internet is an insecure medium and users should be aware that there are inherent risks transmitting information across the internet. Information submitted unencrypted via email or web forms may be at risk of being intercepted, read or modified. If you do not wish to email or send an online form to the Australian Criminal Intelligence Commission you can send enquiries by post to the address above.
This site contains links to other sites. The ACIC is not responsible for the privacy practices or the content of such websites.
- Domain name—the code for the country or type of internet connection a user comes from, such as '.com' '.gov' '.au' '.uk'
- Internet Service Provider—a company or organisation that provides access to the internet for users.
- Law enforcement agency—an agency of the Commonwealth or a State or Territory such as the Australian Federal Police, which exercises powers such as executing a warrant to seize documentation or goods or to search premises etc.


text:
The Washington Supreme Court this week reversed a lower court's decision that had dismissed attorney Matt Woods‘ lawsuit against Seattle's Union Gospel Mission (SUGM) for not hiring him after learning he was in a same-sex relationship. Woods had also told the organization he could see himself "marrying a man and starting a family with another man."
King County Superior Court Judge Karen Donohue originally ruled two years ago that SUGM acted within its rights as a religious nonprofit, which exempts them from the state's anti-discrimination law.
The state's high court ordered that the case be reopened in the lower court, two years after the original ruling.
"To get the affirmation from the court that religious organizations don't have a right to blanket discriminate against LGBTQ people for who they are no matter what the job is a big relief," Woods said. "Especially for members of my community that are so much more likely to experience discrimination in the workplace because of their race or gender identity."
The Washington Supreme Court concluded the original decision "does not facially violate" the state's constitution. However, Justice Barbara Madsen wrote in the majority opinion that the court recognizes that the provision to exempt religious nonprofit groups from anti-discrimination laws "may still be unconstitutional as applied to Woods."
"It is best left to the trial court to determine whether staff attorneys can qualify as ministers and, consequently, whether Woods' discrimination claim under [Washington's Law Against Discrimination] must be barred," Madsen said.