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Epic Holiday Party. Can I use a smartphone to play this slot game? Can I play Epic Holiday Party for free?
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domain: entertainment


Economic development issues are becoming increasingly geopolitical, as the form and importance of today’s agreement in Turkey on grain exports between Russia and Ukraine demonstrates. While today’s crucial agreement and the war of food security narratives between Russia and the West rightly grab the latest headlines, outside of the media spotlight development competition is also heating up between China and the West.
China’s Foreign Minister Wang Yi is traveling this month, visiting Myanmar, Indonesia, Thailand, the Philippines, and Malaysia, hosting cooperation dialogues with Vietnam and Cambodia, and following a recent visit to eight Asia-Pacific island nations. Advancing the achievements of China’s new Global Development Initiative (GDI) is one of the objectives of the trip.
The Asia trip is a week after the G7 announcement of its new Global Partnership for Infrastructure Investment (GPII), which itself fell a day after China’s hosting of 18 heads of state in Beijing for a High-Level Dialogue on Global Development. The GPII announcement also follows a G7 announcement on a new Global Alliance for Food Security (GAFS) in May.
Coincidence? Unlikely. Two and a half years of pandemic and the impacts of the Ukraine war leave both immense development needs and a vacuum in global leadership, which both sides want to fill.


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It doesn’t sound as good as one made of Hawaiian Koa wood, but this ukulele made entirely out of Lego bricks works exactly like a regular one and it sounds quite nice. In the words of its creator, Ross Crawford:
Realizing I’ve never owned a uke, I decided I’d try to make one. But instead of using wood, like any normal person, I decided to use LEGO bricks. Of course, there were some challenges: 1) Shape, 2) Strength, 3) Tuning, 4) Intonation.
The model also had to sustain the tension of the strings, which are tuned to C, F, A and D. Quite a feat. [Brothers Brick]

domain: hobby


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Boston: Little, Brown, and Company, 1933.
Hardcover. First edition. Octavo. Blue cloth stamped in gilt. Erosion of the cloth at the crown, spine lettering rubbed and soiled, a sound good or better copy lacking the dustwrapper. Inscribed by the author to his sister-in-law, Marian Wells Hall, the wife of his brother and fellow author George Seldes: "To my dear sister Marian who shall have honey and myrrh instead of locusts. Gillie. 20 January 1933." Small post-it note affixed in the hand of Gilbert's daughter, the actress Marian Seldes, identifying the recipient. A nice association.

domain: artistic


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Do you remember 2008, 2000 or maybe as far back as 1987? Each generation has one or more stock market crashes etched in its collective memory. Uncomfortable as they are, it’s normal behaviour for stock markets, and to a lesser extent bond markets, to move up and down. Asset allocation is the best approach to manage the various risks involved in investing. It broadly diversifies your portfolio (“investment pie”) by:
Identifying your risk capacity and risk tolerance is critical when developing an appropriate asset mix for your retirement assets. But your investor identity is also influenced by your age, investment characteristics and several other factors. All are used to create your investor profile. Answer the questions below to determine your investor profile and view your ideal asset allocation.
Don’t just use one tool. They aren’t all the same. Try out two or three and compare the results. Wherever you have investment accounts, these firms likely have a tool or questionnaire available for self-assessments. The accuracy of any calculator is limited based on how you answer the questions and the weighting assigned to each question. Small differences may result in different calculators producing different target asset mixes.
The tools select how best to allocate your investments between each asset class, as a percentage of the total portfolio. This your target asset mix. Build your retirement portfolio (all of your accounts designated for retirement) to align with your target asset mix.
Tools, such as asset allocation questionnaires and investor profiles, are designed to suggest appropriate asset mixes for retirement savings. They are not necessarily designed for investing in the short term.
Identifying your retirement portfolio’s asset mix is a crucial step. It helps you to:
Your current asset mix, may be different from your target mix. Aligning the two is crucial. If they don’t match, you could be taking on more or less risk than is suitable for your portfolio. You might think you’re okay but won’t be if an unexpected negative return makes it harder to meet your objectives. To find out if you’re on target, see Rebalance Your Portfolio.
Review Questions Beyond the Investor Profile when examining your target asset mix, to determine if there are any considerations that you should take into account.
As you approach retirement, your investor profile may change. You may need to consider reallocating some of your assets. Begin periodically reviewing your asset mix at least ten years before your planned retirement date.

domain: economics


Actress Sean Young put on her dancin’ shoes and sang a Country song that she co-wrote with a couple of Nashville songwriters at the season finale of Gone Country 2. The show was taped at the Wildhorse Saloon. Her song was called “Time For The Boy To Grow Up”.
Did you know that actress Sean Young (Stripes, Ace Ventura: Pet Detective, No Way Out, Wall Street, Blade Runner, Dune, and Cousins) had a stint as a Country music singer? She appeared in Nashville for the ‘Gone Country’ reality TV series singing Country songs as part of a music competition. Here you'll find our pictures and reviews of her performances at the Wildhorse Saloon, where the show was taped.
Last night was the season finale for Gone Country 2. Actually, the series hasn’t even started airing yet on CMT, but they were taping the final episode ‘live’ at the Wildhorse Saloon. We were front & center and captured these photographs of the celebrities performing.


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Neutral or middle diction: Correct language characterized by directness and simplicity.Enjambment (or enjambement): A line having no end punctuation but running over to the next line.
Literary Terms Test - gtvoice
A P LITERARY TERMS - Houston Independent School
Poetry Terms - Oglala Lakota CollegeDiction (informal or low): Relaxed, conversational and familiar language.
10TH GRADE HONORS ENGLISH LITERARY TERMS: VOCABULARY FOR
Literary Elements Quiz - Hamburg High SchoolPoetry - Basic Terminology. alliteration: repetition of initial sounds in a series of words, e.g.: note.When reading about poems and literature, you will come across a multitude of terms, some of which are familiar, others you.Poetry Vocabulary Terms. Poetry is a word dance that can be as energetic as the.
Literary Terms and DefinitionsSlant rhyme: A near rhyme in which the concluding consonant sounds are identical but not the vowels.Apostrophe: Speaker in a poem addresses a person not present or an animal, inanimate object, or concept as though it is a person.Multiple choice quiz on literary terms found on the AP Literature and Compositon exam.Shakespearean sonnet: A fourteen-line poem written in iambic pentameter, composed of three quatrains and a couplet rhyming abab cdcd efef gg.Answers to Matching Quiz on Literary Terms and Elements of a Story.Rhyme scheme: The pattern of rhyme, usually indicated by assigning a letter of the alphabet to each rhyme at the end of a line of poetry.
Common meter or hymn measure (Emily Dickinson): iambic tetrameter alternating with iambic trimeter.
Bc English 12 Literary Terms Quiz - mybooklibrary.ComIn this quiz you will test your knowledge about the distinctive set of terms that gives poetry its literary uniqueness.Literature quizzes about authors and their books, pictures, pen names, opening lines and prizes.This mutiple choice quiz covers the definitions of a series of poetic terms including alliteration, onomatopoeia, personification, and simile.This Poetry Terms Quiz online can be taken over and over again until 100 percent is achieved.Ballad: A narrative poem composed of quatrains (iambic tetrameter alternating with iambic trimeter).
Glossary of Poetic Terms. The repetition of similar vowel sounds in a sentence or a line of poetry or prose,.This PDF book provide poetry terms quiz with answers document.
Definition Quiz, Literary Character Quiz, Poem Quiz, Literary Terms,.Diction (formal or high): Proper, elevated, elaborate, and often polysyllabic language.This pattern is more common (as dactylic hexameter) in Latin poetry than in English poetry. (Emphasized syllables are in caps.Glossary of Literary Terms No news posted. View. A. Poetry Terms:can also be used in novels,.Scan (scansion): the process of marking beats in a poem to establish the prevailing metrical pattern.
Image: Images are references that trigger the mind to fuse together memories of sight (visual), sounds (auditory), tastes (gustatory), smells (olfactory), and sensations of touch (tactile).Alliteration: The repetition of identical consonant sounds, most often the sounds beginning words, in close proximity.A blending of consonant and vowel sounds designed to imitate or suggest the activity being described.Metaphor: A comparison between two unlike things, this describes one thing as if it were something else.
Learn vocabulary, terms, and more with flashcards, games, and other study tools.Octave: The first eight lines of an Italian or Petrarchan sonnet, unified by rhythm, rhyme, and topic.Assonance: The repetition of identical vowel sounds in different words in close proximity.Browse our pre-made printable worksheets library with a variety of activities and quizzes.


GE Marine announced it has delivered its first new lightweight LM2500 composite gas turbine module to Austal USA for the future USS Santa Barbara (LCS 32).
Tag Archives : Austal USA
25 May 2020
The future USS Oakland (LCS 24) successfully concluded acceptance trials here May 22, following a series of in-port and underway demonstrations in the Gulf of Mexico.
11 Mar 2020
Austal USA hosted the Hon Marise Payne, Australian Minister for Foreign Affairs, for the keel laying ceremony of the future USS Canberra (LCS 30) at its Mobile, Ala. shipyard on March 10, 2020.
22 Jan 2020
The USS Gabrielle Giffords crew successfully demonstrated the fully operational Naval Strike Missile (NSM) for the first time at Exercise Pacific Griffin 2019. Using the ship’s integrated combat system, the crew launched the powerful anti-ship cruise missile at a decommissioned ship.
08 Dec 2019
An audience of over a thousand dignitaries, community leaders, and Austal USA employees celebrated the christening of the future USS Mobile (LCS 26) today at Austal’s advanced ship manufacturing facility.
13 Nov 2019
Austal Ltd is pleased to announce that Austal USA has christened the twelfth Spearhead-class Expeditionary Fast Transport (EPF), the future USNS Newport (EPF 12), at a ceremony held over the weekend at its state-of-the-art ship manufacturing facility in Mobile, Alabama.
22 Sep 2019
The U.S. Navy held a keel-laying and authentication ceremony for the future USS Savannah (LCS 28) at Austal USA’s shipyard Mobile, Ala., on Sept. 20.
26 Aug 2019
The first cut of metal for the future USNS Apalachicola (T-EPF 13) took place on August 19, 2019 at the Austal USA shipyard in Mobile, Alabama.
25 Aug 2019
USNS Puerto Rico (EPF 11), successfully completed the first integrated sea trials for an Expeditionary Fast Transport (EPF) ship Aug. 22. The ship returned to the Austal USA shipyard following two days underway in the Gulf of Mexico.


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[The New Governess]
oil on canvas
19 3/4 x 16"
1836 - 1908.
This was a popular subject in mid-century with an estimated 20,000 governesses leading a precarious life, subject to instant dismissal if they upset the family (notice the numerous travel labels on her trunk), poorly paid but not quite a servant and not one of the family. Given the black dress, she is probably a widow fallen on hard times, or perhaps from a genteel family whose father has died. She seems to be holding the photograph of a man. The novels Jane Eyre and Agnes Grey brought attention to their plight.
This picture was exhibited at the RA in 1877.


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The Indian Olympic Association (IOA) general secretary Rajiv Mehta and wrestling referee Virendra Malik, who were arrested on Saturday for different crimes, will be presented before a Glasgow court on Monday.
The IOA officials were staying in a hotel and not in the Games village along with the 215-member contingent.
While Malik was arrested for alleged sexual assault, Mehta was caught for driving under the influence. Along with drunken driving charges, Mehta has also been charged for injuring two people in a hit-and-run case and for trying to drive away from the incident site, despite being asked to stop by the police, according to The Hindustan Times.
Although the Scotland Police Spokesperson confirmed the arrest, she refused to reveal what charges have been pressed against them.
"On the August 2, a 49—year—old man was arrested following reports of an alleged assault at City Centre of Glasgow. On August 2, a 45—year—old man was arrested following reports of an alleged assault in the west of Glasgow," The Hindu quoted the Scotland Yard spokeswoman.
The Indian Consulate in Edinburgh has been asked by the Indian high commission in London to keep a track of the case.
"We have learnt about the detention of two members of the Commonwealth contingent by the local (Glasgow) police. Our consulate in Edinburgh has deputed an official to Glasgow to keep in close touch with the police to ascertain full facts of the case. We are also in touch with the team," a spokesman at Indian high commission in London said.
Moreover, Sports Minister Sarbananda Sonowal has said that India will take actions against the two officials, if the charges pressed are proved to be true.
"If whatever the media have reported so far is right, definitely our ministry will take appropriate action in this regard," IBNLive quoted him.
India has sent 215 strong athletes from 14 different sporting disciplines to the 2014 Commonwealth Games, which was organized at Glasgow in Scotland, UK. India, which is at the fifth position in the game, has won 64 medals including 15 Gold, 30 Silver and 19 Bronze.

domain: news


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The garbage came from two construction waste bins used during the improvement project at the popular tourist destination, and may have been dumped on the ground by other animals such as birds where the wolves could access it.
Parks Canada’ s law enforcement branch in Banff is investigating, but officials say they don’ t know whether the human garbage was tossed in the bin by passing tourists or by staff working on the project, which has been completed.
Wildlife officials say the wolves were feeding on the garbage, but they don’ t know specifically if they actually got any food.
“There was evidence of food wrappers and other human garbage like juice containers and bottles and cans. There was an opportunity for them to have had a food reward, but we hope they didn’ t,” sad David Gummer, a wildlife ecologist for Banff National Park.
“We’ re now on heightened alert status to keep tabs on the wolves and what their behaviour is, and we’ re hoping we don’ t see evidence of them trying to seek out human food anywhere else.”
This is the wolf pack that has taken up residence in the Bow Valley, including around the Banff townsite. Two of its members have been fitted with GPS collars, so Parks can keep closer tabs on the pack.
The five-member pack has been hunting deer and elk around Banff, which has led to the closure of several areas for public safety and to allow the wolves to feed undisturbed. The wolves were also seen hunting a deer in a residential Banff neighbourhood last year.
As soon as the call came in from a member of the public last Thursday, wildlife management staff responded to the Johnston Canyon parking lot where they found garbage strewn on the ground and evidence the wolves had been into it.
The construction bin was removed the next day.
Gummer said only three wolves were seen accessing the garbage, but he suspects all five members of the pack were in the parking lot and feasting on the garbage, based on tracks in the snow.
He said the industrial construction bin was not intended for household garbage or food waste.
“It’ s really unfortunate. On close inspection it certainly looked like some people had been using the construction bin to dispose of miscellaneous garbage,” said Gummer.
“We don’ t know how it got on the ground. It could have sort of blown out, or been lifted out by other animals like birds that may have accessed it. We don’ t know.”
Parks Canada reminds people to use wildlife proof garbage bins provided throughout the national park.
Any sightings of wolves should be reported to Banff dispatch at 403-762-1470.


Steam turbines are commonly used in renewable energy power plants, specifically geothermal and solar thermal power plants. They are integral components that help convert heat energy from geothermal reservoirs or concentrated solar power into rotational shaft energy, which can then be used to generate electricity via a generator coupled to the turbine. The increasing worldwide emphasis on transitioning to cleaner and more sustainable energy sources has led to rapid growth in investments and construction of renewable energy projects based on geothermal and solar thermal technologies. This in turn is driving demand for steam turbines that help maximize the conversion of renewable heat into usable electric power. The global Steam Turbine Market is estimated to be valued at US$ 16.63 Bn in 2023 and is expected to exhibit a CAGR of 7.3% over the forecast period 2023 to 2030, as highlighted in a new report published by Coherent Market Insights.
Market key trends:
The key driver behind the increasing demand for steam turbines in the market is the rising emphasis on renewable energy adoption globally. Geothermal and concentrated solar power are intermittent energy sources that are complemented by energy storage via steam turbines. They help store thermal energy during periods of high solar irradiation or geothermal activity and dispatch electricity continuously to the grid via steam turbine-powered generators. Technological advancements are also improving the efficiency and power outputs of newer steam turbine designs. Manufacturers are focused on developing ultra-supercritical, supercritical and heat regenerative steam turbine models to extract more rotational power from high-temperature and high-pressure steam. Their widespread adoption in renewable thermal plants will further boost the steam turbine market growth over the coming years.
The global steam turbine market is dominated by the back-pressure segment which holds over 40% share due to its low cost of installation and operation. Back-pressure turbines are commonly used in process industries for cogeneration applications where steam at lower pressure is sufficient to fulfill the process steam requirements. It has high efficiency levels ranging between 80-85%. Other notable segments include condensing segment and extraction segment.
The Global Steam Turbine Market Size is expected to witness high growth over the forecast period of 2023 to 2030 supported by rising investments in renewable power generation.
Regional analysis: Asia Pacific region currently dominates the global market with over 35% share led by countries like China and India. This is attributed to growing investments in renewable energy projects such as solar, wind and hydropower wherein steam turbines play a vital role. In addition, presence of a large industrial base requiring steam for various processes also contributes to market growth in the region. Europe and North America are other major regional markets driven by favorable government policies promoting clean energy adoption.
Key players: Key players operating in the steam turbine market are Neuro Care Group, Myndlift Ltd, Brainmaster Technologies, Inc., Mitsar Co. Ltd, Emotiv, Brainworks, Mindfield Biosystems Ltd., Narbis, Thought Technology Ltd., InteraXon Inc., Mind Media USA Inc., and NeuralScan. They are focusing on development of more efficient and sustainable steam turbine technologies to capitalize on the rising global demand. Players are investing substantially in research activities to make advanced steam turbine designs suitable for various end use industries.
For More Insights, Read: https://www.newswirestats.com/steam-turbine-market-trends-growth-and-regional-outlook-2023-2030/


Russia Space Chief Says Some Of Nationís Satellites May Have Been Sabotaged [View all]
By Associated Press,
MOSCOW ó Some recent failures of Russian satellites may have been the result of sabotage by foreign forces, Russiaís space chief said in comments apparently aimed at the United States.
Roscosmos chief Vladimir Popovkin stopped short of accusing any specific country of disabling Russian satellites, but in an interview Tuesday in the daily Izvestia he said some Russian craft had suffered ďunexplainedĒ malfunctions while flying over another side of the globe beyond the reach of his nationís tracking facilities.
Popovkin spoke when asked about the failure of the $170-million unmanned Phobos-Ground probe, which was to explore one of Marsí two moons, Phobos, but became stranded while orbiting Earth after its Nov. 9 launch. Engineers in Russia and the European Space Agency have failed to propel the spacecraft toward Mars, and it is expected to fall back to Earth around Jan. 15.
Roscosmos spokesman Alexei Kuznetsov refused to elaborate on Popovkinís comments, which marked the first time a senior Russian government official has claimed that foreign sabotage has been used to disable one of the countryís satellites.


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First, Gabrielle Giffords. Now Steve Scalise. We didn’t learn anything in the six years between their shootings.
Our lawmakers face a choice — they can support the president’s executive orders on trade and immigration or they can advocate the principles that helped build Utah’s economy. But they can’t do both.
Automation at Utah’s new crime lab will help prevent future rape kit backlogs. But to fulfill its potential, it needs to be fully staffed — and funded.
This week’s topics: The LDS Church gets recognized for fighting child abuse, candidates file for city offices in Weber and Davis counties, the Air Quality Committee was disbanded and the Weber County Commissioners opt to hire a consultant for a close-to-home issue.
Utah must find a way to help mentally ill prisoners get the psychological treatment they need before someone else commits suicide in a county jail — someone like Matthew Ryan Hall.
A health clinic jointly operated by Ogden and Weber County is a creative way to control costs. But don’t stop there — open it up to community partners.
We cannot address hatred until we begin to understand it. And that requires data — accurate, real-time data.
This week’s topics: Ogden’s booming music scene, summer food programs, Utah senators take the wrong side on Paris and Diesel Brother’s disregard the right thing to do.


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domain: geography


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text:
When the two-sided four-party Paris peace talks began in early 1969, it was quickly apparent that they were little more than a propaganda platform. Hanoi was occupied with rebuilding its military capability in the south without the large southern component that had been sacrificed in 1968 and was content to delay serious negotiations until it had gained a stronger position on the battlefield. Under strong political pressure to end American involvement in the war and with the Paris negotiations at an impasse, the new administration of Richard Milhous Nixon (1913–1994) shifted to a strategy of removing American forces from Vietnam and giving responsibility for the anti-communist struggle back to the South Vietnamese. This was possible because the Second Republic government in Saigon was stable and enjoyed a relatively high measure of popular support, and also because the communist defeats in 1968 had temporarily, but significantly, reduced the battlefield threat.
Secretary of Defense Melvin Robert Laird (b. 1922) made plans to redeploy nearly all American military forces out of Vietnam by the end of 1972. The first redeployment was announced in the summer of 1969 and the drawdown continued thereafter on schedule. General Creighton Williams Abrams, Jr. (1914–1974), who replaced Westmoreland in 1968, espoused a new strategy of “one war,” which aimed to integrate the operations of the Vietnamese and American armies and also to integrate civilian and military operations.
Under Westmoreland’s command, the Vietnamese army was for the most part pushed aside from battlefield responsibilities as American forces conducted search and destroy operations. Furthermore, the equipment provided by the Americans to the Vietnamese was generally inferior to that available to commun- ist forces, particularly in the quality of small arms and individual weapons. Under Abrams, the South Vietnamese army was equipped with up-to-date weapons that were equivalent to the quality of arms used by its enemy. Abrams organized joint Vietnamese–American operations that were to some extent designed as training exercises. As American redeployment progressed, the Viet- namese increasingly assumed responsibility for defending the country. At the same time, American programs for assisting civilians in battle zones that from 1967 had begun to be integrated into American military operations were turned over to the Vietnamese. These policies, commonly referred to as “Vietnamiza- tion,” needed time for implementation, and major campaigns in Cambodia and Laos during 1970 and 1971 aimed to gain time by keeping communist forces off balance and away from South Vietnamese cities
. In early 1970, the Cambodian army commander, Lon Nol, who opposed the arrangements that had allowed the Vietnamese communists to use Cambodian territory, deposed Sihanouk. Sihanouk then joined a Chinese-sponsored alliance between the Vietnamese and Cambodian communists as Lon Nol appealed to the US for assistance. South Vietnamese and American forces advanced into Cam- bodia, forcing the Vietnamese communists to evacuate their headquarters and supply bases. These events were accompanied by widespread massacres of Viet- namese residing in Cambodia, victims of Cambodian resentment against the dominance of Vietnamese communists that Sihanouk had allowed in the eastern part of the country. Americans and South Vietnamese believed that this oper- ation, which continued into the summer of 1970, helped to keep Vietnamese battlefields relatively quiet for a year, enabling the Vietnamization process to gain momentum. Opposition to this operation in the US Congress, however, resulted in a law prohibiting American ground troops from thereafter entering Cambodia or Laos.
War continued between Lon Nol and the Cambodian and Vietnamese com- munist forces, but the port of Sihanoukville was thereafter closed to the com- munists, and North Vietnam became more dependent upon its supply lines through southern Laos. In early 1971, South Vietnamese forces entered southern Laos in an operation designed to sever the communist supply lines during the winter dry season. In a series of battles, North and South Vietnamese forces both suffered heavy casualties. Although the initial aim of the operation was not fully reached, North Vietnamese plans were sufficiently disrupted to give the Vietnamization policy another year of relative calm. By early 1972, the number of US ground troops in Vietnam was insignificant and the American presence had become more like the Kennedy phase of advising with logistical and air support.
At the international level, Nixon endeavored to exploit the deepening Sino- Soviet dispute by diplomatically engaging each of these major communist powers and persuading them that they had more to gain from strengthening relations with the US than from supporting the North Vietnamese. Nixon understood that the Cold War was shifting from a bipolar confrontation toward a three-corner game with possibilities for prying one or both of the communist powers away from Hanoi. China had begun to withdraw its troops from North Vietnam after the end of American bombing and the beginning of American redeployment, and it began to be apparent that the Chinese were not in favor of Hanoi gaining control of South Vietnam. While China had supported Hanoi so long as the American presence in South Vietnam was on a threatening scale, it was not keen to have a united Vietnam on its southern border. On the other hand, the Soviet Union was ready to provide Hanoi with all that it needed to conquer the south and thereby gain a potential ally in the increasingly rancorous confrontations that were characterizing Sino-Soviet relations.
The troubled state of Sino-Soviet relations made both powers want to strengthen ties with the US in order to isolate the other. Nixon enjoyed the benefit of China and of the Soviet Union competing to build strategic relation- ships with the US. There were plans for Nixon to visit both countries during the first half of 1972. Le Duan understood that the international situation was changing in a direction that threatened to downgrade the importance of North Vietnam to its allies and decided to try for a quick military victory.
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domain: politics


text:
The final book in the New York Times bestselling House of Secrets series that was called "a breakneck, jam-packed roller coaster of an adventure" by J. K. Rowling. Created by Hollywood director Chris Columbus (of Harry Potter fame) and bestselling author Ned Vizzini (It's Kind of a Funny Story), with the acclaimed author of the Codename Zero series and the Fourth Stall saga, Chris Rylander.
With their last adventure just barely over, the Walker kids thought life would finally go back to normal. But things don't remain calm for long . . . especially when the colossus Fat Jagger turns up in San Francisco Bayand he's in danger!
With the police closing in, the Walkers must figure out how to save their giant friend. When a frost beast is spotted in Santa Rosaand more mystical creatures start appearing all over Americait's soon clear that the characters from Denver Kristoff's works are invading the real world. It's up to Brendan, Eleanor, and Cordelia to reenter the book world one last time to keep the worlds from colliding, causing mass destruction.
They will have to track down three Worldkeepers hidden in Kristoff's booksmagical items that when used together will seal the worlds off for good. But the Walkers' first move leads them straight into the Wild West, with lethal outlaws and lawless deputiesand that's just the beginning. They'll encounter dinosaurs, aliens, killer robots, and the Wind Witch herselfwith new friends and oldand be faced with some of the deadliest choices they'll ever have to make. The scariest thing of all could be deciding who to trust, since everyone is hiding something. . . .
Generi Gialli Noir e Avventura » Narrativa di Avventura per bambini e ragazzi » Thriller per bambini e ragazzi , Bambini e Ragazzi » Narrativa » Avventura, giallo, thriller » Fantasy e magia » Temi personali e sociali » Famiglia e relazioni , Fantasy Horror e Gothic » Fantasy per bambini e ragazzi
Editore Balzer + Bray
Formato Ebook con Adobe DRM
EAN-13 9780062192530 9780062192530

domain: literature


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Christian Dada—the Tokyo-based brand founded by Masanori Morikawa in 2010—isn’t as well known within the American marketplace as it is in Japan and Europe. But that, perhaps, is slowly starting to change. For Spring ’18 menswear, Morikawa was inspired by an idea of “losing power in our modern, consumer-driven world.” What resulted was a mishmash of a collection that was inconsistent at times, but it presented a strong case for adding a bit (or a lot, depending on your bravery) of quirkiness to your closet. Hyper-beaded trousers, so thick with embellishment that some bits ended up skittering across the runway? Why not. A gator-hide belt—literally in the shape of the original skin—wrapped around the waist? Sure. In slightly more applicable IRL scenarios, Morikawa proffered a baseball shirt—lengthened to just above the knee—with the word Christian displayed as if dripping in blood. (This particular graphic treatment was influenced by a French street artist named Zeus, who paints liquidated logos.) And there were more examples to be had: Free-flying belts (trendy) and yarns from sweaters; slide sandals with ornate, almost Old Western hardware; and long-strapped necklaces all combined to create something that provoked thoughts of idiosyncratic wardrobe possibilities down the line.
The epicenter of runway news, street style, and emerging trends.


Parents everywhere learn what a struggle school can be once their children start attending preschool or kindergarten—but arguably one of the greatest shared struggles might very well be Picture Day.
One mom this week, while simply attempting to prepare her son for his first school photos, came out with the perfect example of how impossible this whole Picture Day thing can be.
Amber McFadden, a mom from Little Rock, Arkansas, decided that attempting to rehearse the steps for Picture Day was the best plan for her three-year-old son, Landon White—including the winning smile every parent hopes to see when the pictures come back.
In a practice run at home the day before Picture Day, everything was as it should be. McFadden shared on Facebook two adorable photos of her smiling son, Landon, in a Picture-Day-worthy outfit.
"We've been practicing this smile since yesterday. Hopefully his school pictures look this good."
Amber M. McFadden - Ariel Raine @arielraineh / Twitter
But as any parent will tell you—some things just don't go according to plan, no matter how much you rehearse them.
When the proofs for Landon's school pictures came back for approval, McFadden was less than pleased.
In three of the four photo options, Landon was placed in front of a harvest-style wood-plank background, surrounded by harvest pumpkins and a "thankful" sign. In these three photos, Landon looked less-than-thankful as he frowned or pouted his way through the photo shoot.
In the final, fourth photo, Landon was placed in front of a blank-white backdrop, and in the photo, he offered a wide, closed-mouth smile.
McFadden shared these pictures with her sister, Ariel Raine, who shared the pictures and her reaction on Twitter on Monday.
In the tweet, Raine said:
"So my sister has been preparing my nephew for his school pictures in advance this year. This was the outcome. I've been screaming all day."
So my sister had been preparing my nephew for his school pictures in advance this year. This was the outcome. I’ve… https://t.co/hXjCudtYJM— Ariel Raine (@Ariel Raine) 1573535450.0
By Thursday, the tweet had gone viral with more than 45-thousand retweets.
Many parents have shared in the laughter.
Some even deemed one of the resulting Picture Day photos as meme-worthy.
@arielraineh This right here, is a legendary meme! Thank you for your service. https://t.co/TZ9PbB2aV6— Sulaiman (@Sulaiman) 1573636490.0
@arielraineh Lool he said “ya’ll really thought I was gonna take a cute photo” https://t.co/GjPBdE3LE2— blkloveisland 🖤 (@blkloveisland 🖤) 1573614112.0
@arielraineh omg lmaoooo he’s SUCH a cutie though 🥺❤ the lil practiced smile is perfect— DACIA MONÉT (@DACIA MONÉT) 1573539256.0
@arielraineh https://t.co/HdatBPh5mm— Matt (@Matt) 1573650040.0
Others shared their own Picture Day fails.
@arielraineh @hellocmb giving me the same vibes https://t.co/gCQip5gLew— danielle 🧸 (@danielle 🧸) 1573661585.0
@arielraineh look at my nephew’s school pictures lmfao https://t.co/GJLw38taoV— tika lacienigga (@tika lacienigga) 1573603722.0
@arielraineh @JackeeHarry My son went in his bag and pulled out the 'Uncle Rico' on em! 😭😭😭😭 https://t.co/w7nGt5XAeK— Amy Czumak (@Amy Czumak) 1573658472.0
@arielraineh Meanwhile here’s my little brother... https://t.co/GXG3NjT0xI— Yon. (@Yon.) 1573621774.0
@arielraineh last year mine inexplicably decided to pose like an orphan from an animé movie begging for porridge…??… https://t.co/CS8vMXjO39— J. No (@J. No) 1573697877.0
@arielraineh This post reminds me of Nyemah in our family portraits from 2016 😭😭😂 https://t.co/WdIn0Lf6Gg— LiLi 💌 (@LiLi 💌) 1573610909.0
@arielraineh My child’s Pose 1 & Pose 2: https://t.co/BluVNywWaH— fal. (@fal.) 1573656708.0
@arielraineh lol compared to what my sister did for her pictures that’s nothing 😂 https://t.co/Sp5jVB3vsW— ✨Tatyana✨ (@✨Tatyana✨) 1573693410.0
@arielraineh This is my 4 year old 😳. I’m not even sure what that is .. grimace? Threatening smirk? https://t.co/2Aqq6NgOPs— Maryam Moshiri (@Maryam Moshiri) 1573632274.0
@arielraineh Hahaha awww reminds me of this little boy's pics https://t.co/7LqDg4isWl— Kimikaze (@Kimikaze) 1573823984.0
@arielraineh @aintthatjackie brrruhhh tell me why my brother did some shit like this 🤣🤣🤣🤣 https://t.co/GPZem089XD— dak 🍣🍷 (@dak 🍣🍷) 1573609353.0
@arielraineh we practiced smiling with my lil bro too & this was the result lmao https://t.co/tD1jCHSvJS— 💤 (@💤) 1573619066.0
McFadden shared that she's still going to buy the pictures, even though they weren't the photos she was hoping for.
Undeniably, these photos are hilarious—and still pretty darn cute.
Parents, take heart: Even though kids can make the darnedest facial expressions, they still take some adorable pictures.


The director’s hero is none other than Ulaga Nayagan Kamal Haassan while the hero’s director is the maverick ManiRatnam. Yes Kamal is going to direct ManiRatnam’s son Nandan launching him through a Hollywood movie. Nandan son of ManiRatnam and Suhasini Mani Ratnam is going to debut as hero. Suhasini initially wanted her son to be a politician and serve the people. But in order to get the fame in public, cinema industry is the best platform, she gave a thought. Nandan is no one till now and has no reputation in public so far. Kamal is going to concentrate on this lad after his heavy project Vishwaroopam. Nandan might have learnt that Kamal Hassan is his grandfather as he is uncle to his mother Suhasini. Even there are good relations between Kamal and Maniratnam. That is why Mani wanted his son to be launched by the hands of god of acting. Complete details are yet to be out.


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MEC Mobile App to Establish Companies Online28 March 2016
The Ministry of Economy and Commerce (MEC) has launched a new mobile service that enables the establishment of companies online, through its mobile application. The service is available on both iPhone and Android devices under the name MEC_QATAR. The service enables investors to establish companies online at any time or from anywhere in the world. The new service, MEC said, is part of a number of smart-phone applications provided by the ministry in order to improve business processes in Qatar as well as streamline and speed-up business incorporation procedures thereby promoting Qatar's business and investment environment. To read more, please visit this link.


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My name is Samantha Skelton and I am an actor, screenwriter and producer. I graduated in 2016 with a Bachelor's in Screenwriting from California State University Northridge. I truly have a passion for every aspect of filmmaking and dedicate my time to creating quality content. I currently have a few projects in the works: a feature film, short film, and web series. I train and continue to work on my craft at Warner Loughlin Studios, as I have for the past few years. I love meeting and collaborating with new people, let's see what we can make!
Mysteries of the Unexplained
Television (Sci-Fi) Actress The world is full of mysterious events that defy explanation. Each episode tells the story of one incredible phenomenon and investigates every possible explanation - from the anchor of logic to the far end of the supernatural.
Walking Among Them
Film (Short and Comedy) Actress "Walking Among Them" chronicles the misadventures of Heinrich Schleinman, documentarian extraordinaire, aligned with his poorly-treated gaffer in search of a man who lives among sheep in the hills of San Antonio, Texas. The film stars Cyle Conley, Josiah Huyard, and Dennis Hurley. The mockumentary gets its inspiration from a man living in the Swiss Alps, Thomas Thwaites, who abandoned his comfortable life for three days to live among a herd of goats.
Film (Short and Comedy) Actress Awkward, nerdy Evan is pushed by his friends to be more social with women. What his friends do not realize is how difficult this task may be for someone as nerdy as Evan.


The lockdown may have led to the closing down of gyms and jogging tracks, but it has not wavered the spirit of fitness enthusiasts who have taken to online sessions with their trainers. One such fitness lover who has been working out with her personal trainer is actor Kriti Sanon. If you follow her on Instagram, you would know that her regular at-home workout routine is quite inspiring.
“Keeping yourself fit in current times is really important and spot-running is an easy way to do that at home. To check my fitness levels I have taken up the #30secPowerRun challenge,” she said in her a post.
Along with her fitness routine, what also caught our attention is her sportswear that features shades of wine red, white and neon orange. The linear pattern complemented her lean frame, while the fabric made it easy to perform the exercises. An apt outfit definitely sets the mood, and Bollywood knows how to workout in style.
Recently, the Raabta actor also shared an image of her yoga session in a throwback picture. Since yoga is more of a relaxing fitness regime, Kriti wore a comfy tank top and cotton shorts. “Take care of your body, and it will take care of YOU! … Get out of your lazy beds and do some exercise- walk around, yoga, mat workout, dance (my fav), cardio, anything.. just wake up every inch of your body, and you’ll have a great day!!”, she said in her post.


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The Going Against the Crowd Blogathon is hosted by Dell On Movies and KG’s Movie Rants. Basically, it’s a Blogathon to showcase the times you weren’t a sheep and went against the critical consensus as you are your own unique, individual person.
The rules for participation are simple:
1. Pick one movie that “everyone” loves (the more iconic, the better). That movie must have a score of at least 75% on Rotten Tomatoes. Tell us why you hate it.
2. Pick one movie that “everyone” hates (the more notorious, the better). That movie must have a score of less than 35% on Rotten Tomatoes. Tell us why you love it.
3. Include the tomato meter scores of both movies.
4. Use one of the banners in this post, or feel free to create your own.
5. Comment on this post, or at Dell on Movies, with the two movies you intend on writing on.
6. Publish your post on any day from Monday August 22 through Friday August 26, 2016.
I’m going to honest here, John Hitchcock from Hitchcock’sWorld is far better at showing his disdain for this movie more articulately than I possibly could. So basically, if you want to see some good criticism read his review. Ever since I heard Jean Luc-Godard initially refused to subtitle his film named Film Socialisme I greatly disliked him, before I’d even seen any of his films. I sought to change that a few years ago and decided to watch Breathless…and what a mistake that was.
I’m not an expert (as is clearly evident), but plenty of experts have written essays about this film and the highly influential effect in had on the entirety of the French New Wave movement. I can’t deny that filmmakers such as Jean-Luc Godard and François Truffaut (a much better and more likeable filmmaker) were hugely important and films such as Breathless and The 400 Blows (a much better and more likeable film) were also hugely important...but I just hate Breathless.
From what I remember of it, I loathed every second of it. I disliked the main character, his actions, the misogynistic treatment of his girlfriend, the way he embodied the stereotype that the French are arrogant (he fancies himself as much as he fancies himself the new Humphrey Bogart), the way he killed a cop, for no reason, and stupidly never got rid of the body. He’s dreadful person, and even bigger idiot, the idea we’re supposed to care or even become engaged with this guy is ludicrous to me. Even if he’s not supposed to be likeable, his dumb behaviour is just astonishing.
The film’s editing, which is supposedly ‘innovative and unique’ just looks like Godard couldn’t be bothered as the film’s editing is all over the place. His overuse of jump cuts gives the film a very messy, choppy look. Apparently Godard did this to trim down the running time, it’s either that or he just wanted to rebel against the cinematic norms. It’s a superficial film, remembered only for what it looks like rather than anything of any depth. It was ground-breaking at the time, but now it really should be film that should be confined to the history books.
I’m not going lie, unlike like most people on reddit and various other social media sites I don’t think Neill Blomkamp is anything to write home about. Yes, District 9 is a superb film that intelligently uses the arrival and treatment of aliens as an interesting allegory for racism and whilst it wasn’t exactly subtle it was streets ahead of his next film, Elysium, whose central theme of rich vs poor was so ham-fisted and obvious its actually one of very few films I hate. Why can’t black people and Latinos create a civilised world and why do they need the only white person still on Earth to save them?
Chappie is no masterpiece by any stretch of the imagination, and as you can tell from the image above is was negatively reviewed by both critics and the Rotten Tomatoes community (even more so than Elysium). However, I really liked it. I even liked Die Antwoord in this film, who had plenty of critics commenting upon their performances in the film.
Chappie was a film that was a little rough around the edges, but I found myself really engaged in the film because I cared about the central character which was bought to life due to a terrific Sharlto Copley who gives the film an emotional backbone. Because of this, the film overcomes its lame and dumb villain, its flawed story and inconsistent tone. It’s a film a bares similarity to Blade Runner where a robot, or machine, recognises its own mortality. I like it and didn't deserve the small critical mauling it got.


text: Starting at midnight tonight and running trough midnight Thursday, the two day sportsman lobster season is here. Also known as mini-season. It is a race to see how many red circles with a red line through them will be placed over lobster images or diver images? "Bug Fever" can spark many, for lack of a better term, idiots to enter the water for the first time since regular lobster season ended March 31st at midnight. Scuba diving is a little more complex than riding a bicycle, especially with the extra task loading of lobster catching equipment. I hated driving a 24 passenger dive boat during this madness. The regular season starts August 6th, with plenty of time before closing the end of March.


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In 2019, The U.S. Environmental Protection Agency (EPA) worked directly with stakeholder communities to identify and facilitate policy and planning measures that promote green infrastructure and help address flood management and water quality needs.
The American Alliance of Museums recommends that museums build flexible plans for reopening that are regularly reviewed and refined based on the latest science.
Tree planting can help communities achieve many resiliency goals such as cooling heat islands, reducing stormwater floods, and building neighborhood cohesion.
The 2019 Water Infrastructure and Improvement Act (WIIA) codified EPA’s Integrated Municipal Stormwater and Wastewater Planning Approach Framework in the Clean Water Act.
Improving urban forests is one of the solutions to achieving several of the United Nations Sustainable Development Goals and making cities healthier and more livable for people.
Building upon an initial 6000+ cities committed to GCoM at the time of the signing of the Paris Agreement, cities continue to make significant and ambitious commitments to meet the climate challenge.
The impacts of climate change are already being felt in communities across the country.
More frequent and intense extreme weather and climate-related events, as well as changes


Tanzanian opposition leader Tundu Lissu and former Chair of the Tanganyika Law Society Fatma Karume have called for economic sanctions against President John Magufuli’s regime.
Mr Lissu, a former presidential candidate and deputy chairperson of political party Chadema, and Karume called upon the international community to levy economic sanctions, claiming that donor funds could be used to further destabilise the opposition rather than for development. However, the two said that the opposition remains strong in Tanzania despite President Magufuli’s determination to limit their political activities.
Mr Lissu ruled out changing election laws and democratising of elections through a legal process in the next five years due to what he termed as a “dictatorial” regime in his home country.
“I know more about our electoral law and the impossibility of changing of democratising our elections by using the courts. It will simply not happen,” said Mr Lissu. “I am completely hopeful that all is not lost yet.”
Mr Lissu and Ms Karume were speaking during a webinar hosted by the Brenthurst Foundation and the Konrad-Adenauer-Stiftung, under the Governance Accountability Platform banner on Friday. “Given what has happened, any form of assistance to Magufuli will be read by Magufuli and will be presented to the people of Tanzania and it is being presented so, as an endorsement of his murderous regime. It will be taken as proof that what he is doing is correct and he is being supported internationally,” said Mr Lissu.
Ms Karume said the Tanzanian administration had politicised the army and police forces.
“The army is weaponised and so is the police force,” she said.
She termed the decision by President Magufuli to use of the army to take personal property as illegal and unconstitutional.
“This is an army that went to Southern Tanzania and confiscated from the people of the south a cashew nut crop because the Commander-in-Chief had asked them to do this, completely unaware that they can’t do that under our Constitution.”


text:
Phantom Quartz with Chlorite
This mesmerising piece of Phantom Quartz outwardly appears simple but contains incredible depth and dimension. It contains beautifully formed phantom peaks dusted in green chlorite; a tribute to the mountainesque landscapes from which this piece was grown. Placing this piece in a light-filled room will showcase the true brilliance of its natural clarity.
The Mystic Lore for Phantom Quartz is universal awareness
"I am connected to Universal Awareness"


Over a final 10 years, a East Coast has undergone some harmful whirly seasons, that have caused a good volume of damage. Recently, a 2015 foresee of a Atlantic Hurricane Season has been released, and a East Coast has perceived good news from a predictions. The 2015 whirly deteriorate has been expected to be really mild. Though, the National Oceanic Atmospheric Association (NOAA) can not contend a same for a West Coast.
El Nino is pronounced to be a reason because this year’s whirly deteriorate is being suppressed. The whirly deteriorate has already begun in some tools of a easterly with high winds and rain, though it customarily does not start until Jun 1st, and it routinely lasts until Nov 30th. According to NOAA, there is a 70 percent probability that 11 storms will start via a season. Winds will be during slightest 39 mph, and scientists have settled that 3 to 6 out of a 11 storms will spin into hurricanes. Two of a storms will be Category hurricanes of a three, four, and 5 range, with winds removing adult to 111 mph.
The East Coast continues to accept good news from a 2015 foresee of a Atlantic Hurricane Season, given it will continue to sojourn next normal. Predictions that have been done are from prior forecasts, that have always followed a week before a start of a season.
However, Tropical Ana started a deteriorate early this month in North Carolina that brought in lots of sleet to Virginia and South Carolina, though no repairs has been reported. Mike Halpert, a conduct of a Prediction Center of National Weather Service’s Climate, settled in Mar a El Nino that has been expected is going to start after within a season, and it is going to be really weak. Recently, an email sent from scientists Philip Klotzenbach and William Gray, from a University of Colorado, settled they also design a 2015 Atlantic Hurricane Season to be one of a weakest. Below is a list of whirly names that will take place in a Atlantic Hurricane Season of 2015.
El Nino is famous as a meridian intermittent phenomenon, that includes a atmosphere and ocean. The NOAA is means to establish when an El Nino occurs, due to a signature symbol of sea surfaces becoming warmer than usual.
NOAA does not wish East Coasters to trust that an Atlantic Hurricane Season next normal means they can suffer a prohibited summer. Meteorologists explain that people contingency keep in mind that reduce than normal seasons are also famous to lead to catastrophic events. For example, in 1992, there was a news of a below-normal whirly season, though a initial charge that shaped was a Category 5, and it broken south Florida. According to NOAA, a final integrate of years have been quiet; however, it is still a opposite story for a Eastern and Central Pacific.
The NOAA has expected a Eastern Pacific will have a 70 percent probability of experiencing an above-normal season. A operation of 15-22 storms are expected to start in a Eastern Pacific region, and 12 of those 15 storms are pronounced to spin into hurricanes, though 5 to 8 out of a sum volume of storms are expected to be pleasant depressions. In a Central Pacific, a organisation expected a same commission volume of 70, and a whirly deteriorate above normal with a ratio of 5 to 8 cyclones. The East Coast receiving good news from a 2015 Atlantic Hurricane Forecast, still gives high hopes of reduction vital Category hurricanes to occur.
By Krystle Mitchell
CBS News: What to design in 2015 NOAA whirly forecast
ABC Action News: 2015 Atlantic Hurricane Forecast expelled by officials
Artemis: Atlantic Hurricane Season 2015
Photo Courtesy of Brent’s Flickr Page – Creative Commons License
Photo Courtesy of Martinez Julian’s Flickr Page – Creative Commons License


text:
LINCOLNSHIRE schools have been given a prestigious food award.
Schools in the county that have excelled in transforming their food culture will be presented with a Bronze Award tomorrow (Thursday), in recognition of the region’s trailblazing healthy eating and practical food education.
Children and staff from 18 schools across the region are expected to attend the ceremony.
The schools work with the Food for Life Partnership to try to transform their food culture and that of their communities by working to reconnect children with growing, cooking, eating and appreciating climate-friendly and healthy food.
The Food for Life Partnership Bronze Award means that schools have started to serve seasonal school meals, with 75 per cent of the dishes being freshly prepared by a very well-trained school cook.
Pupils and parents are also involved in planning improvements to school menus and the dining experience, and every pupil has the opportunity to visit a farm and do cooking and food growing activities during his or her time at school.
Andrea McCormack, a healthy schools coordinator at one of the county’s schools, said: “Through the support of the partnership team and the achievement of the Bronze Food for Life Partnership Award, we have raised awareness and begun to change the food culture at our school.
“We’ve consulted with the children regarding lunchtimes and have made changes to improve the lunchtime experience.
“Some of our younger children have just completed a growing project whereby they grew vegetables in recycled containers such as milk crates, milk containers and juice containers.
“They then used the potatoes to make a special salad and took the salad home to share with their family along with the recipe. “We believe that everyone deserves to have the opportunity to have knowledge of the impact of food on health and that of the planet.
“We hope that the knowledge the children are gaining from this initiative will have an impact on future generations to lead a healthy lifestyle.”
The schools are catered for by caterers First College, Food for Thought and The Farm Kitchen.
Food for Thought and The Farm Kitchen have achieved the Gold Food for Life Catering Mark for their high-quality, climate-friendly and organic meals.
Victoria Howe, Director of The Farm Kitchen, said: “We are very proud of our Gold award and very much enjoy working with The Food for Life Partnership.
“We feel passionately that the benefits of eating high quality delicious meals and having an understanding of where and how they have been produced, are fundamental to life.”
The Food for Life Partnership is a network of schools and communities across England committed to transforming food culture.
The initiative is funded by the Big Lottery Fund and led by the Soil Association.

domain: food


text:
Best meal I ever ate:
Dunno, but it probably involved grits.
My current drink of choice:
A good beer.
I really wish I could:
be Anthony Bourdain's travelling producer.
My "Go-to" dinner party dish:
Coconut Cream Pie. It is the bomb.
My favorite comfort food:
I scream for ice cream.
My most tattered cookbooks:
What? They better not be tattered. I'll smack you with a spoon.
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The pre-engineered metal building system is a building enclosure system that always includes a structural system and often includes roof and wall cladding. The general idea of the system is represented in the diagram below. The structural system consists of rigid frames that are fabricated from plate steel and “cold formed” into an “I” shape through a manufacturing process. These rigid frames consist of roof beams and columns that are field bolted together. These frames can span large distances without intermediate supporting columns. The frames are spaced at intervals between 15’ and 60’ and can span, column-free, up to 300’ across a building.


text:
Spinal metastasis of adrenal cortical carcinoma (ACC) is exceedingly rare with only few cases having been reported previously; thus, there is still short of imaging proof.[1–4] In general, ACC has poor prognosis and high recurrence rates, even with aggressive resection.[5,6] To date, management of malignant adrenocortical carcinoma of spine has remained under evaluation, with no standard criteria. Herein, we are presenting an analysis of a rare case of spinal metastases of adrenocortical carcinoma with paravertebral extension treated with cement augmentation, radiotherapy, radiofrequency ablation of psoas major muscle occupying lesions, right chest wall, liver and kidney recess together with targeted programmed cell death 1 (PD-1) therapy. In the short term, the patient's conditions improved significantly postoperatively. After reviewing pertinent literature, we discussed common diagnosis and management considerations in patients with metastatic spinal adrenocortical carcinomas.
2 Case report
In December of 2016, a 40-year-old woman with no notable medical history presented to another hospital, with incidental elevation of blood pressure. Abdominal computed tomograhy (CT) revealed a right adrenal mass (6.3 cm × 6.2 cm × 6.0 cm). An excision of the adrenal mass was performed, and pathology revealed features consistent with pheochromocytoma. Subsequently, she was discharged from the hospital with a prescription for 10 mg of phenoxybenzamine twice a day to control her blood pressure.
The patient presented to our institution in February 2018. Upon examining and questioning the patient, she stated she has been experiencing progressive back pain for approximately 3 months, after a sudden collision. The pain in her back can reach 8 points using the visual analogue scale and cannot be alleviated with rest and hot compresses. Initially, the patient attributed the pain to her overwork and thus did not seek medical attention. The patient denied experiencing any loss of consciousness, chest palpitations, diaphoresis, paresthesia, headaches, fatigue, and facial flushing. She also denied convulsions, nausea, vomiting, and other constitutional symptoms. Upon further questioning, she recalled she had been diagnosed of right pheochromocytoma, received surgical treatment of right adrenalectomy in another hospital, followed by no further treatment. No pertinent family history was identified, including, hypertension, cancer, and congenital birth difficulties.
Upon physical examination, the patient showed decreased sensation to pin-prick and fine-touch sensation of right lower extremity and exhibited an 5-/5 strength in the right lower limb. Deep tendon reflexes revealed normal for both knee jerk and Achilles tendon reflexes bilaterally. Ataxia was absent. Cranial nerves, mini mental, and the rest of the neurological examination showed no abnormalities. Routine laboratory tests were ordered, including electrolytes, liver and kidney function tests, and complete blood count. Genetic evaluations for RET, VHL, SDHB, SDHC, SDHD, an 24-hour urine fractionated catecholamines were ordered. Abdominal CT, spinal magnetic resonance imaging (MRI), and fluorodeoxyglucose-positron emission tomography/CT (FDG-PET/CT) were ordered to visualize the metastatic lesions, assess the stability of the vertebral column, and to aid in the formulation of a surgical approach. Preoperative hemodynamic and cardiovascular assessments included electrocardiogram, echocardiogram, and chest x-ray. The results of the laboratory studies were almost within normal range, except that the 24-hour urine fractionated catecholamine revealed a elevated level of 10.56 μg/24 h (normal: 1.74–6.42 μg/24 h), and adrenocorticotropic hormone elevated to 109 pg/mL (normal: <46 pg/mL). Genetic investigation was negative for RET, VHL, SDHB, SDHC, SDHD mutations. x-ray showed vertebral pathological fracture of L1 (Fig. 1A and B). MRI of the lumbar spine revealed widespread abnormal signals of L1 vertebrae in keeping with diffuse metastatic infiltration (Fig. 2A-L). MRI of spine showed progressive spinal cord compression secondary to the epidural component of the L1 mass, with increased metastatic marrow infiltration of the L1 vertebral body, which mimicked a solid tumor (Fig. 3A-F). The tumor infiltrated through the L1 vertebral body into the right pedicle and posterior elements. Extraosseous spread into the right lateral aspect of the epidural space extending posteriorly, resulting in compression of the nerve root. The spinal cord is displaced and spinal cord stenosis is significant at L1 level (Fig. 3A-F). A PET/CT scan revealed multiple osteolytic lesions of the spine, especially prominent in L1 and paravertebral region. PET/CT also demonstrated multiple suspicious metastases in the L1, paravertebal region, psoas major muscle occupying lesions, right chest wall, right liver and kidney recess (Fig. 4).
First, we performed CT-guided puncture and biopsy of right psoas major muscle mass. After consultation with pathology department, the pathology report of the right psoas major muscle mass and the primary adrenal tumor both confirmed adrenocortical carcinomas, not consistent with pheochromocytoma (Fig. 5A-G). After full preoperative evaluation and multidisciplinary discussion, cement augmentation was performed to destroy the functional tumor and stabilize the spine under local anesthesia.
In brief, percutaneous vertebroplasty at L1 was performed according to the original surgical plan. For the posterior approach, we used C-arm for perspective positioning, L1 vertebral lesion was identified as surgical target, and the right L1 pedicle puncture point was located. Then 2% lidocaine was used for local infiltration anesthesia, and the puncture needle was inserted through the cannula. Under the C-arm fluoroscopy, the L1 vertebral lesion was penetrated through the right pedicle of the L1, and then we finished biopsy of the L1 mass. Then we send out the tissue for pathological examination. Bone cement for vertebroplasty was introduced. Under the perspective, the 8.0-mL cement of L1 was slowly pushed through the putter, and the biopsy passage was closed. Fluoroscopy confirmed the good dispersion of bone cement. The operation was successful and intraoperative bleeding was about 30 mL. The blood pressure and heart rate were stable during the operation. Postoperatively, x-ray of the spine revealed part of bone cement leaked into the paraspinal region (Fig. 6A and B). Postoperatively, the patient experienced significant pain relief. Pathological examination confirmed the diagnosis of malignant adrenocortical carcinoma (Fig. 7A-G).
One week after the operation, the patient's right lower extremity muscle strength improved to grade V compared to the preoperative status, grade V-. Moreover, VAS score of her back pain improved to 0–1 points compared to the preoperative status, 8 points. As the patient did not develop severe adverse effects, she was discharged and was monitored as an outpatient. Following wound healing, the patient underwent rehabilitation therapy. Radiotherapy, radiofrequency ablation, and targeted PD-1 therapy were also conducted. Radiofrequency ablation of psoas major muscle occupying lesions, right chest wall, liver, and kidney recess was completed within 1 month after the operation. Radiotherapy of the right psoas major muscle (60Gy/15f, 5f/w) and spine (45Gy/15f, 5f/w) was performed in the second month after the operation, respectively. Six months after the operation, she received the first cycle of targeted PD-1 therapy. The postoperative 6-month and 1-year follow-up visit showed no tumor progression and no new symptoms.
Adrenocortical carcinoma is a rare malignancy with poor prognosis. The incidence of ACCs is approximately 0.7 to 2.0 cases per 1,000,000 individuals per year, and the metastatic forms account for a small fraction of all cases.[1,2] In literature, ACCs are more commonly diagnosed during the fourth and the fifth decades of life for the sporadic form.[3,4] Metastatic lesions can be localized or systemic, with the latter being marginally more common.[5–11] Localized metastases tend to involve surrounding structures (including pancreas, spleen, liver, intestine, and retroperitoneum), whereas systemic forms occur most frequently in the lungs and liver, and metastatic spread to the spine is one of its rare manifestations.[12–15] Few reports of ACCs metastatic spread to the spine causing clinical symptoms have been documented so far. The location of the spinal lesion determines the neurological deficits, and there is a great deal of variability.[16,17] Like most spinal disorders, spinal metastatic ACC may result in vertebral collapse, spinal instability, and progressive neurologic damage, which may cause local, radicular, or axial pain in addition to neurologic deficits from mild radicular weakness to paraparesis.[18,19] Moreover, back pain is also a common symptom and it may make the differential diagnosis more difficult. As is consistent with our patient, spinal metastases are generally extradural and located most frequently at thoracic and lumbar spine.[1–5,20–26]
Clinical studies looking at metastatic ACC to the spine is lacking due to the extremely low incidence rate. Imaging studies including CT, MRI, and bone scan are nonspecific, making it difficult to differentiate metastatic spinal ACC from other common spinal lesions. However, imaging studies may play a crucial role in the decision making of surgical intervention. FDG-PET/CT scan is also insightful, as ACC usually exhibits high 18F-fluorodeoxyglucose uptake.[1–3,18–20] Imaging should be followed by pathological confirmation, as the “criterion standard” diagnosis of ACC relies on pathological findings.[1–5,27,28] Standard of care for advanced ACC (stage IV) is medical therapy in the form of mitotane.[1–5,29] Mitotane is reported to be the only adrenal-specific and most effective therapeutic strategy currently available for patients with ACCs. Given its high recurrence rate, mitotane can be used either alone or in combination with cytotoxic drugs (doxorubicin, etoposide, cisplatin) from initial diagnosis.[1–3,29,30–34] Research into newer therapies, including tyrosine kinase inhibitors (insulin-like growth factor 1 receptor) and rapamycin signaling components (mechanistic target of rapamycin) show some promise; however, it will still take several years from clinical application.[1,5,31–34]
Surgery is the best treatment of choice for metastatic spinal ACCs causing back pain, radiculopathy, and myelopathy. Surgical intervention in the case of advanced ACC with spinal metastases has met with some success, to date. Total resection of local regional lesions is associated with improved survival rates, according to several retrospective studies.[3,32,33] Total or grossly total resection with stabilization is the most preferred intervention for lesions involving a single segment or two adjacent segments, as it is locally curative and provides good long-term outcomes. Debulking resection is also noted to be of benefit in cases whose medical treatment failed.[3–5,32–34] However, surgical indications should be carefully considered for patients with spinal metastatic ACC, as the procedures are associated with prognosis of this rare entity.[1–5,33–37]
Osteoplasty by cement augmentation may be a treatment option for patients with metastatic ACC in the spine, who cannot undergo appropriate surgery or decline open surgery.[33–38] However, we need to fully recognize the potential risk of complications in bone cement applications. The safety of this approach still needs to be confirmed in further studies with larger sample sizes and longer follow-up periods. One postoperative complication was cement leakage into the canal and subsequent spinal cord compression.[16,17,37] Under this circumstance, surgical extent, cement volume, and postoperative complications are critical factors that need further investigation. The present case is the first reported so far that focused on patients with spinal metastasis from adrenocortical carcinoma which was treated by percutaneous vertebroplasty. It aimed to contribute to the appropriate surgical treatment of these patients.
The survival benefit of resection of spinal metastases is still unproven. However, such a procedure does have the benefit aiming at controlling residual tumor.[38,39] The improved survival benefited from reducing the tumor burden, decompressing the spinal stenosis to alleviate radiculopathy or myelopathy, and facilitating subsequent adjuvant therapies. Radiotherapy has also shown promise as a treatment option for spinal metastatic ACC. Response rates to radiotherapy have been reported up to 42%.[38,39] In fact, the German ACC team recommends that adjuvant radiotherapy be applied for lesions of stage III or of indeterminate resection margins following resection. In addition, PD-1, an immunoinhibitory receptor, has shown the ability to function as a marker for tumor prognosis.[40,41] To date, the PD-1 and programmed death-ligand 1 (PD-L1) expression in ACCs and its prognostic significance are still uncertain. PD-1-positive or PD-L1-positive tumors may indicate immune active tumors that have a better response to anti-PD-1 and/or anti-PD-L1 therapies because they are correlated with the poor prognosis of many malignancies.[40,41] As is reported in our case, anti-PD-1 therapy was performed postoperatively, and therapeutic effect has been achieved in clinical manifestations and imaging features.
Although uncommon, metastatic ACC of the spine should be part of the differential when the patient presents with neurological deficits or other symptoms. Clinical symptoms are generally the result of the tumor burden, and pathological results remain the “criterion standard” for diagnosing ACC. The treatment of spinal metastasis of ACC requires careful consideration of its aggressive nature. Complete resection, combined with radiotherapy or targeted PD-1/PD-L1 therapy, would be a logical approach to spinal metastasis of ACC. Osteoplasty by cement augmentation might also be good choices for treatment of spinal metastatic ACCs. With a multidisciplinary team approach, proper planning, and adequate perioperative medical management, metastatic ACC in the spine can be managed effectively.
The authors thank their colleagues at the Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College.
Conceptualization: Shuzhong Liu, An Song, Yipeng Wang, Yong Liu.
Funding acquisition: Shuzhong Liu, Yipeng Wang, Yong Liu.
Investigation: Shuzhong Liu, Xi Zhou, An Song, Yong Liu.
Resources: Shuzhong Liu, Xi Zhou, Zhen Huo, Yong Liu.
Supervision: Yipeng Wang, Yong Liu.
Writing – original draft: Shuzhong Liu, Xi Zhou, An Song.
Writing – review & editing: Shuzhong Liu, Yipeng Wang, Yong Liu.
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