text:
|Home | About | Journals | Submit | Contact Us | Français|
Alpha-1-adrenergic receptors (α1-ARs) regulate coronary arterial blood flow by binding catecholamines, norepinephrine (NE), and epinephrine (EPI), causing vasoconstriction when the endothelium is disrupted. Among the three α1-AR subtypes (α1A, α1B, and α1D), the α1D subtype predominates in human epicardial coronary arteries and is functional in human coronary smooth muscle cells (SMCs). However, the presence or function of α1-ARs on human coronary endothelial cells (ECs) is unknown. Here we tested the hypothesis that human epicardial coronary ECs express functional α1-ARs. Cultured human epicardial coronary artery ECs were studied using quantitative real-time reverse transcription polymerase chain reaction, radioligand binding, immunoblot, and 3H-thymidine incorporation. The α1B-subtype messenger ribonucleic acid (mRNA) was predominant in cultured human epicardial coronary ECs (90–95% of total α1-AR mRNA), and total α1-AR binding density in ECs was twice that in coronary SMCs. Functionally, NE and EPI through the α1B subtype activated extracellular signal-regulated kinase (ERK) in ECs, stimulated phosphorylation of EC endothelial nitric oxide synthase (eNOS), and increased deoxyribonucleic acid (DNA) synthesis. These results are the first to demonstrate α1-ARs on human coronary ECs and indicate that the α1B subtype is predominant. Our findings provide another potential mechanism for adverse cardiac effects of drug antagonists that nonselectively inhibit all three α1-AR subtypes.
Alpha-1-adrenergic receptors (α1-ARs) regulate coronary artery blood flow in response to the catecholamines norepinephrine (NE) and epinephrine (EPI). α1-ARs on vascular smooth muscle cells (SMCs) mediate contraction. Interestingly, however, α1-AR stimulation causes minimal constriction of normal coronary arteries, but markedly constricts coronary arteries with disrupted endothelium (Baumgart et al. 1999; Heusch et al. 2000). A likely mechanism is loss of endothelial nitric oxide synthase (eNOS) activation and vasodilator NO when endothelial cells (ECs) are lost (Zembowicz et al. 1991; Jones et al. 1993). However, nothing is known about α1-ARs on human coronary endothelial cells (ECs).
α1-ARs exist as three molecular subtypes, α1A, α1B, and α1D. All three subtypes are activated by NE and EPI, but differ in amino acid sequence, tissue expression, and signaling (Graham et al. 1996). Little is known about α1-AR subtypes in ECs of any vascular bed or species. A few earlier studies suggested that the α1D subtype was present in ECs from different vascular beds in animals (Filippi et al. 2001; de Andrade et al. 2006; Mendez et al. 2006) and in human umbilical vein ECs (Vinci et al. 2007). However, α1-ARs in epicardial coronary artery ECs have never been studied, in animals or humans.
Recently, we showed that the α1D is the predominant α1-AR subtype in human epicardial coronary arteries, which have low levels of the α1B subtype (25% or less of total α1-ARs) and little or no α1A (Jensen et al. 2009b). The α1D subtype is also expressed and functional on human coronary SMCs (Jensen et al. 2009b) and causes constriction of mouse coronary arteries (Turnbull et al. 2003; Chalothorn et al. 2003). In striking contrast with coronary arteries, the human and mouse myocardium and cardiac myocytes express near-equal levels of the α1A and α1B subtypes, with little or no α1D (Jensen et al. 2009a; O’Connell et al. 2003).
Which α1-subtypes are present on human coronary ECs is potentially very important clinically. Subtype-nonselective α1-adrenergic antagonists, such as doxazosin and prazosin, are in widespread clinical use, especially to treat prostate disease in men and hypertension. However, large clinical trials detected adverse cardiac effects of nonselective α1-antagonists (ALLHAT CRG 2000; Cohn 1993). We suggested recently that adaptive signaling through the α1A and α1B subtypes in myocardium and myocytes might explain these adverse effects in part (Jensen et al. 2009a; O’Connell et al. 2006). Furthermore, inhibiting an α1-AR subtype in epicardial coronary ECs might disturb endothelial-dependent vasodilation. Thus, the presence of α1-ARs on epicardial coronary ECs would suggest another possible explanation for cardiac side effects of nonselective alpha-blockers. Here, we tested the hypothesis that human epicardial coronary ECs express functional α1-ARs.
Clonetics normal human coronary artery ECs were from Lonza (Walkersville, MD, #CC2585, Lots 7F3649, 7F3667, and 7F4280). All cells were cultured in Clonetics EGM-2 medium [including human recombinant epidermal growth factor, fibroblast growth factor, insulin-like growth factor-1, vascular endothelial growth factor, heparin, and 2% fetal bovine serum (FBS)] and were used between passages 3 and 10, at 80–100% confluence.
Primary human coronary artery EC cultures came from heart transplants at the University of California, San Francisco (UCSF), with the approval of the UCSF Committee for Human Research and with full informed consent. The heart was perfused with cold cardioplegia in situ and explanted immediately into ice-cold physiologic solution. Epicardial coronary arteries were dissected, cleaned rapidly of fat, transported in ice-cold physiologic solution, then opened longitudinally and digested 20 min in Hanks buffer with collagenase type II (1 mg/ml, Worthington). The endothelium was removed with gentle scraping; the vessel was washed three times; collagenase was inactivated by EGM-2; and the cellular fraction was centrifuged at 1,200 rpm for 5 min. Cells were plated and grown in EGM-2 as with Lonza ECs and assayed at ~80% confluence.
Clonetics normal human coronary artery SMCs from Lonza (#CC2583) were cultured in Dulbecco’s modified Eagle’s medium (DMEM) with 10% FBS for 3–11 passages and harvested at ~70% confluence.
Cultured coronary artery ECs from one T75 flask were washed with phosphate buffered saline (PBS), and ribonucleic acid (RNA) was extracted, purified (Qiagen RNeasy Mini Kit), and treated with DNase (Turbo DNAfree, Ambion). The approach was validated previously (Jensen et al. 2009a).
RT reactions used 1 μg RNA, SuperScript III Reverse Transcriptase (Invitrogen), random hexamers (Invitrogen), and oligo-dT (Roche). qPCR was done in triplicate in an ABI PRISM 7900HT Sequence Detection System (SDS) with 5% of the RT product, primers at 125 nM, and SYBR Green Master (Roche) with ROX reference dye. Data were analyzed with SDS software version 2.3 (Applied Biosystems).
Relative quantitation of PCR products used the ΔΔCT method, with normalization to two reference genes for improved accuracy, where arbitrary units (AU) were (CT = cycles to threshold, and ΔΔCT = [(mean target gene CT)-(mean CT of β-actin+TBP)].
ECs or SMCs (12×100 mm dishes or 16×T75 flasks) were rinsed, scraped directly into binding buffer (5 mM Tris–HCl, pH 7.4, 5 mM EDTA), and sonicated. α1-AR saturation binding used 85–95 μg cell protein in 1 ml/tube with six concentrations (0.04–1.2 nM) in triplicate of 3H-prazosin (Perkin-Elmer); phentolamine (10 μM, Sigma #P7561) defined nonspecific binding. All incubations were 60 min at 30°C. Prism 4.0a (GraphPad Software, San Diego, CA) analyzed binding data.
For experiments, EC cultures in 35 mm culture dishes (Falcon) were serum-starved for 2 h in DMEM with 5 mg/ml bovine serum albumin (BSA), then were pre-incubated for 15 min without or with α1-AR-antagonists including BMY-7378 (8-[2-[4-(methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione dihydrochloride, Sigma #B134) or prazosin (Sigma #P7791). The nonselective β-AR antagonist l-propranolol (Sigma #P8688) was also present throughout. Agonists or vehicle (100 μM ascorbic acid) were then added including l-NE-bitartrate (Sigma #N5785), l-EPI-bitartrate (Sigma #E4375), A61603 (N-[5-(4,5-dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl]methanesulfonamide hydrobromide, Tocris #1052, Ellisville, MO), or UK-14,304 [5-bromo-N-(2-imidazolin-2-yl)-6-quinoxalinamine, 5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine, Sigma #U104].
After agonist treatment, homogenates were made in radioimmunoprecipitation assay (RIPA) buffer with protease and phosphatase inhibitors. Total cell lysates were used in immunoblots with antibodies for total-ERK1/2 (Cell Signaling rabbit pAb #9102), phospho-ERK1/2 (Cell Signaling rabbit mAb Thr202/Tyr204 #4370), total-eNOS (BD Transduction Laboratories #610296), and phospho-eNOS (Cell Signaling Ser-1177 #9571; BD Transduction Ser-633 #612665). Signals from enhanced chemiluminescence detection were quantified with a Bio-Rad ChemiDoc Molecular Imager (Hercules, CA).
Antibodies for cell phenotyping were PECAM-1 (R&D Systems #BBA7), smooth muscle actin (Zymed #08-0106), and sm-MHC (Biomedical Technologies #BT-562, Stoughton, MA).
DNA synthesis was estimated by measuring incorporation of 3H-thymidine. ECs at 80–90% confluence in 24-well plates in EGM-2 were serum-starved and pre-incubated for 4 h in DMEM with BSA (5 mg/ml, Sigma #A7030) and l-propranolol 1 μM, without or with prazosin 0.2 μM. Cells were then incubated in the same medium with 3H-thymidine, without or with NE or EPI. After 24 h, cells were extracted with 10% trichloroacetic acid for 12 h, washed, dissolved in 1% SDS for 1 h, and counted in mini-vials with 5 ml Opti-fluor (Perkin-Elmer).
Results are mean ± SEM. Significant differences (p<0.05) were tested using Student’s unpaired t-test for two groups, and analysis of variance (ANOVA) and Tukey’s multiple comparison for more than two groups. Concentration–response curves were fit with Prism 4.0a.
Human coronary ECs from Lonza were from two females (ages 56 and 57) and one male (age 21). These ECs all expressed high levels of PECAM-1 mRNA and no sm-MHC, as expected (data not shown). Our primary cultures of human epicardial coronary ECs were from one male without coronary artery disease (age 46) and were validated by positive immunoblot for PECAM-1 and by negative immunoblot for smooth muscle actin and sm-MHC (data not shown).
We quantified α1-AR subtype mRNAs using qPCR with primers validated previously that span the single intron in each α1-AR subtype gene to eliminate artifacts from genomic DNA contamination (Jensen et al. 2009a). In the Lonza ECs, 92% of total α1-AR mRNA was α1B, with the remainder small amounts of α1D, and little or no α1A (N=4 independent cultures from three subjects, Fig. 1a). There was no detectable β3-AR mRNA (data not shown). In our primary human epicardial ECs, 90% of total α1-AR mRNA was α1B (N=2 cultures from one subject).
To test α1-AR protein levels, we used saturation radioligand binding with 3H-prazosin. We could not use immunohistochemistry or immunoblot, because there are no antibodies specific for α1-ARs, among 10 antibodies that we tested (Jensen et al. 2009c), or three antibodies tested by others (Pradidarcheep et al. 2009).
Saturation binding identified 34 fmol/mg protein of total α1-ARs in coronary ECs, with a Kd 0.07 nM, and specific binding 90% of total at the 3H-prazosin Kd (Fig. 1b). For comparison, in parallel experiments, we found that Lonza human coronary SMCs contained 17 fmol/mg protein of total α1-ARs. We did not perform competition radioligand binding on ECs given the marked predominance of α1B mRNA in our qPCR assays.
To test for functional α1-ARs in human coronary ECs and to determine the α1-AR subtype at the protein level, we used immunoblot to quantify dual Thr202/Tyr204 phosphorylation (activation) of ERK. ERK is a key target for α1-ARs in cardiac myocytes (Huang et al. 2007) and is a key element of important signaling pathways in ECs that promote angiogenesis (Chung et al. 2008), and EC migration, survival, and proliferation (Lian et al. 2001; Mavria et al. 2006; Nakagami et al. 2001; Secchiero et al. 2003).
Human coronary ECs from Lonza were treated 15 min with the non-subtype-selective natural α1-AR agonists NE and EPI, and the α1A-selective agonist, A61603, in the presence of propranolol, a β-AR antagonist. NE increased phospho-ERK by 2.2-fold, and the general α1-AR antagonist prazosin reduced this activation by 70% (p=0.01, N=6–10 cultures; Fig. 2a–b). The α1A agonist A61603 did not activate ERK (N=3; Fig. 2a). The subtype-nonselective α2-AR agonist UK-14,304 (10 μM) increased phospho-ERK by only 1.11-fold.
These data indicated that an α1-AR subtype activated ERK in human coronary ECs and that the subtype was not the α1A, because A61603 was inactive. To determine whether the α1B and/or α1D activated ERK, we used an α1D-selective agent, because there are no reliable α1B-selective agonists or antagonists. We quantified ERK phosphorylation after stimulation with NE (1 μM) for 15 min, in the presence of propranolol to block β-ARs, and varying concentrations of BMY-7378 (1 nM–1 μM), the α1D-selective antagonist.
Previously, we found that BMY-7378 competed for 3H-prazosin binding to human epicardial coronary artery α-ARs at two receptor sites, one with high affinity (log IC50 -10.9, the α1D) and the other with low affinity (log IC50 -5.6, the α1A or α1B; Jensen et al. 2009b). In the present experiments, BMY-7378 inhibited NE-stimulated phospho-ERK with a log IC50 -6.5, very close to the low affinity log IC50 (N=5 cultures; Fig. 2c). These data showed that NE-induced ERK phosphorylation in human coronary ECs is not mediated by the α1D, because BMY-7378 inhibited with low affinity, and therefore is mediated by the α1B.
In summary, human coronary artery ECs expressed functional α1B-ARs that activated the important intracellular mediator ERK in response to stimulation by modest concentrations of adrenergic agonists.
eNOS is a key regulator of EC function, including vasorelaxation and angiogenesis (Zembowicz et al. 1991; Murohara et al. 1998), and is activated by α1-ARs in some systems (Hodges et al. 2005). To test whether α1-ARs in human epicardial coronary ECs signal through eNOS, we treated with α1-AR agonists and measured increased phosphorylation of eNOS at two common activation sites (Ser-1177 and Ser-633).
NE (1 μM) and EPI (2 μM) in the presence of propranolol each transiently increased phosphorylation of eNOS at Ser-1177, with a maximum at 30 min (Fig. 3a). In three independent cultures, α1-AR stimulation increased phopsho-eNOS (Ser-1177) by 1.85-fold over vehicle (p=0.01) but did not change phosphorylation at Ser-633. The α1A-selective agonist, A61603, did not increase eNOS phosphorylation at either Ser-1177 or Ser-633 (data not shown).
These data indicated that an α1-AR, most likely the α1B, activated eNOS at Ser-1177 in human coronary artery ECs. However, we were unable to detect NO production in our cultures using the fluorophore DAF-2 or the Griess reagent.
Increased DNA synthesis in ECs is a marker for cellular proliferation and angiogenesis. To test whether stimulation of α1-ARs on human coronary ECs increases DNA synthesis, we measured 3H-thymidine incorporation after treatment with varying concentrations of NE (1 nM–20 μM) in the presence of propranolol. NE increased 3H-thymidine incorporation by a modest but significant extent (maximum 1.3-fold, p=0.04 by ANOVA, N=3–5), with a low EC50 (39 nM) (Fig. 4). Prazosin (0.2 μM) eliminated stimulation by NE (data not shown), indicating that the effect was mediated by α1-ARs. By comparison, 5% FBS increased 3H-thymidine incorporation by 2.6-fold.
This study provides the first characterization of α1-ARs in human epicardial coronary ECs and identifies the α1B as the predominant and functional α1-AR subtype. The α1B subtype is present at relatively high density, and stimulation of the α1B with modest doses of agonist activates ERK and eNOS and increases DNA synthesis. These results raise the possibility that the α1B-AR subtype might have a role in the important adaptive processes mediated by coronary ECs.
We used qPCR and pharmacology to identify the α1B as the predominant and functional α1-subtype, because α1-AR antibodies are not specific for α1-ARs or α1-subtypes (Jensen et al. 2009c; Pradidarcheep et al. 2009). By qPCR with validated primers, human coronary ECs expressed >90% α1B mRNA, with very little α1D, and no detectable α1A. In functional experiments, NE and EPI stimulated phosphorylation of ERK-Thr202/Tyr204 and eNOS-Ser-1177, and the nonselective α1-antagonist prazosin blocked stimulation by 70%. The potent and selective α1A agonist A61603 did not activate ERK, and the general α2-agonist UK-14,304 had a minor effect. To distinguish the α1B from the α1D, we used the α1D-selective antagonist, BMY-7378, because there are no drugs sufficiently selective for the α1B. BMY-7378 inhibited α1-stimulated ERK phosphorylation with low affinity, not the high-affinity characteristic of the α1D. Thus, these data identified the α1B-subtype as functional in human epicardial coronary ECs.
The high level of the α1B in ECs points to an important difference in α1-subtypes in human coronary ECs and SMCs. Recently, we used mRNA and functional assays to show that the α1D subtype is predominant and functional in human coronary SMCs (Jensen et al. 2009b). The α1D is also predominant when assayed by qPCR and radioligand binding in intact human epicardial coronary arteries (Jensen et al. 2009b). However, when binding was done on isolated cells, as in the present study, the density of the α1B in ECs was twice that of the α1D in SMCs (34 vs. 17 fmol/mg). Thus, the much larger total mass of SMCs likely explains the α1D predominance in intact coronaries, rather than a higher density of α1-ARs on SMCs than on ECs. In fact, it is notable that a minor population of the α1B is detectable in intact human epicardial coronaries (less than 25%; Jensen et al. 2009b).
As noted in the “Introduction,” α1-stimulation causes minimal constriction of normal coronary arteries but leads to markedly augmented vasoconstriction in coronary arteries with disrupted endothelium. The α1D is predominant in coronary SMCs (Jensen et al. 2009b); the α1D can cause coronary constriction in the α1A and α1B double knockout mouse; and coronary constriction is blunted in the single α1D knockout mouse (Chalothorn et al. 2003; Turnbull et al. 2003). Therefore, it is interesting to speculate whether loss of the coronary EC α1B might be responsible for α1-mediated constriction through the α1D when the endothelium is disrupted, as in atherosclerosis. The coronary EC α1B might mediate counter-regulatory vasodilation by stimulating eNOS, as shown here. The α1B might also have a role in EC proliferation and angiogenesis, given the stimulation of 3H-thymidine uptake found here. More sophisticated studies in knockout mice will be needed to test these hypotheses, because the α1B and α1D are very difficult to distinguish by pharmacology, especially in intact animals.
In summary, our present and past results indicate that the α1-AR subtypes are expressed heterogeneously in the human heart. The α1B is in human epicardial coronary ECs; the α1D is in human epicardial coronary SMCs (Jensen et al. 2009b); and the α1A and α1B are in human myocardium (Jensen et al. 2009a). Drugs used for prostate disease and hypertension that block all α1-subtypes nonselectively have adverse cardiac effects in human clinical trials (Cohn 1993; ALLHAT CRG 2000; ALLHAT 2003), and mouse knockouts show that loss of cardiac α1A and α1B signaling could account for these adverse effects (O’Connell et al. 2003, 2006). The α1A subtype has a protective role in cardiac myocytes (Huang et al. 2007; Chan et al. 2008), and the α1B in epicardial coronary ECs might also have an adaptive role. Potential risks of blocking the α1A and α1B might be avoided with α1D-selective drugs, such as naftopidil, to relax both prostate and coronary smooth muscle (Takei et al. 1999; Nishino et al. 2006; Kojima et al. 2009).
PCS was supported by the Department of Veterans Affairs, and the National Heart Lung and Blood Institute at the National Institutes of Health, USA. BCJ was supported by the GlaxoSmithKline Research and Education Foundation for Cardiovascular Disease Award to Young Investigators, and the University of California, San Francisco, Foundation for Cardiac Research.
Open Access This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.


text:
Most of us can not resist the boy-meets-girl romantic fairy-tale setup.
We want that classic story to tell our future grandchildren about the magical moment we met their grandfather “our soul mate”. Some women fall in love with the fairy-tale in itself. We become curious of our surroundings not truly grasping the impact of the choices we make. Questions asked never receive a straight answer you get thrown in a maze of riddles. So, who really has time to understand the possibilities of failure when your at a tea party with the Mad Hatter eating cookies and cakes. Not realizing soon you will be falling down the rabbit hole to awaken from bliss into a beautiful nightmare.
In every old-fashioned fairy-tale there is a beginning that leads you into the journey. Mine started on a yellow school bus. Everyone knew each other already and I was the new girl. I remember one day this guy walked from the back of the bus and sat next to me. He had a nice smile and a cheery disposition. When he spoke I already knew in my gut why he was there. He introduced himself and asked me what was my name. He said one of his guy friends thought I was attractive and convinced him to do his dirty work. I turned around to the back and he pointed in his direction. I quickly turned back and said you knew before you asked I would say no. Then we both laughed and talked until his stop. After that he sat next to me everyday. This young man became my best friend. Now, I wonder if everything happens for a reason then our friendship was apart of my destiny or maybe God must have blinked.
Within a year, we were an item and he would always nag me about having to wait an entire year before he could date me officially. Becoming high school sweethearts didn’t come naturally to my surprise. Nothing changed between us expect we carried a different title. He walked me to my classes, we went to lunch together , we talked on the bus, and we stayed up all night talking or fell asleep on the phone then did it all over again. What we had was a simple routine. After six months, our relationship disintegrated from lack of quality time and rumors. It may have taken awhile but we both decided to remain friends.
Throughout my college years he popped in and out of my life. He moved back to Nashville, TN the summer before my senior year. Do to family issues he was homeless. So, I talked to my uncle and he agreed to rent him a room. I went over everyday to check on him and drove him to job interviews or anywhere he needed to go. Then it happened, he said he wanted to rekindle what we had. That wasn’t what scared me it was the fact he was ready to get married and have kids. I wasn’t ready for something so serious,
because I had no real life experience. I was very sheltered growing up and he was the wild child.
As a result, I told him I couldn’t be with him. I believed that I made the right choice by not rushing into an unstable earnest commitment, because I would never what to hurt someone I cared about by living a lie. The reminder of my senior year I missed him terribly everything reminded me of him, but we weren’t speaking. Until one afternoon,
I was on a three-way phone call with him and a mutual friend. He said he had big news then blurted out he was engaged with a baby on the way. I’d never thought I could feel the pain of being shot through the heart without it breaking my skin. I was bleeding internally so holding a conversation was out the window. At that moment, I knew any feelings or hopes of us being together in the future were over. Life on the other hand has a funny way of proving you wrong.
Less than a year later, he contacted me and to my disbelief I wasn’t angry.
There wasn’t any exchanges of questions passing through the channels of my brain.
I jumped in head first into a never ending pool of uncertainty. He said he was
separated from his fiancé and he needed to know how I felt about him once and for all. True romantics call this action a golden moment for the main characters to confess their harbored feelings thus beating the odds of a love lost. Well, I did just that I confessed my love for the first time, but I began to feel regretful for putting myself in such a vulnerable position after not hearing from him for weeks. Turns out after we got back in touch and talked about the possibility of him moving back to be with me. I saw a facebook posting of his saying he was engaged again. On his status was a wedding ceremony date a month away, location, and invitations for anyone interested in coming. If you recall what I said earlier about pain it doesn’t even scratch the surface of what I felt then. It’s clear my heart wasn’t the only deceiver it didn’t betray me alone. I lost a love interest and my best friend.
I’m not sure of all the life lessons that will come my way. I suppose the universe has a greater meaning of karmic ties and I will become a better human being because of it.
One thing I have learned from this situation is I don’t believe in fairy-tales.
No, I believe in love. Love isn’t a fantasy its real unlike fairy-tales it can easily be experienced when focused on the source it comes from. The light of love is inside of us all so please let it shine bright enough for the world to see.

domain: literature


text:
The Maryland arts community was stunned to learn that Maryland Hall for the Creative Arts was singled out as the only nonprofit to have its funding deleted from the state capital budget ("Hogan snubs Busch with $2M cut," May 15).
This capital project funding was approved by the General Assembly — both Republicans and Democrats — for enhancements and renovations at Maryland Hall, including improvements to make the community arts center more accessible for those with disabilities.
This unprecedented action will harm the thousands of patrons, students, artists, volunteers, parents and supporters of Maryland Hall who benefit from this treasure in our community.
The Annapolis Symphony Orchestra, Ballet Theater of Maryland, Annapolis Opera, Chesapeake Youth Symphony Orchestra and Annapolis Chorale are all partners in the ongoing project to update Maryland Hall. They all will be affected by the delay caused by this significant cut in state funding.
We urge that the money be restored so that Maryland Hall can continue to enrich the community and transform lives. We appreciate the continued support of the elected officials and community members who support Maryland Hall and who regard the funding of the arts, communities and education as a priority.
Linnell Bowen, Annapolis
The writer is president of the Maryland Hall for the Creative Arts.

domain: finance


text:
The Mesoterapia is a medical treatment that consists in micro injections of substances lipolíticas to correct the celulitis and flacidez.
The most recommended is uses a cocktail of products depending on the zone to treat. For example:
For the celulitis edematosa incorporate Extract of Meliloto (improves the circulation, reduces the retention of liquids, favours the lymphatic drainage),and Extract of Artichoke (by his action depurativa and drenante).
For the celulitis compact or fibrous incorporate Organic Silicon (that it stimulates the fibres of collagen, elastin and proteoglicanos)
For the flacidez incorporate DMAE (sour hialurónico + dimetilaminoetanol),since it gives back firmness to the tissues, countering the flacidez.
To obtain some optimum results the most advisable is to make of 12 to 14 sessions, with intervals of 7 days.
In some occasions recommends do a second cycle of other 10 - 12 sessions spent some two or three months.

domain: health


text:
First Kiss Friday
»»————- ♡ ————-««
Every Friday I share the first kiss from a book. This week it’s My Heart Weeps by Pamela S Thibodeaux.
»»—— My Heart Weeps ——-««
The story of one woman’s journey
through grief into new life
Before she could react or protest, he had her backed up against the wall, her body pressed firm against his chest, and his arms wrapped around her so tight she could scarcely breathe. Where Kidd’s kiss was tender, gentle, Garrett’s was anything but. His lips swooped over hers in an embrace that robbed her of the very air she needed to live. A kiss so fierce her knees threatened to buckle. Sensations battered her like a thousand tiny tornadoes until she found herself plastered against him, her hands fisted in his hair, her mouth demanding as much as his.
A guttural sound echoed in his throat and Garrett hauled her closer still for a brief, desperate moment, then eased her away.
“I’m not going to finish this here and now, not like this,” he said, his voice raw, eyes fierce. “You’re much too precious for that. But you think about it all those nights while you’re home, alone, and hurry back.” His eyes softened, tone gentled. “I’ve got a ride scheduled in less than fifteen minutes, so I won’t be in the lodge when you stop by. Take care of yourself. Call anytime you want to talk. Come back soon.” He brushed his lips across hers in a tender caress, opened the door and walked out.
Melena crumpled onto the nearest chair. Her breath escaped in jagged pants. Sparks indeed! Tiny pinpoints of pleasure bathed her senses in light and color. Electrical vibrations skittered and jumped along every nerve she possessed. She placed a hand against her body lest the pounding organ in her chest should hammer its way out. A sob shuddered through her. She pressed a fist against her lips and willed some semblance of control to her racing pulse.
7 thoughts on “First Kiss Friday”
Thank you SO much for spotlighting Melena and Garrett’s first kiss, Ellen! Sorry I’m so late checking in – last week was a madhouse of award & graduation ceremonies and parties!
Wow, wow, wow!
Wonderful! Enjoyed it very much!
I always enjoy reading your novels. Best wishes for the success of this one.
THANKS Kara, Carol & Jacqueline!
I appreciate your support
Good luck and God’s blessings to All of you.
Love this excerpt, and it comes from a great read.
THANKS LoRee! I appreciate your support
Comments are closed.


MS4 Permit Updates. May 9, 2014. Jay Hoskins, P.E. Metropolitan St. Louis Sewer District. MS4 Permit Updates. MS4 Permit Renewal 3 rd Term Permit Stormwater Management Plan Highlights Federal Rulemaking Show-Me Rain Gardens Website. MS4 Permit Renewal.
Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.
May 9, 2014
Jay Hoskins, P.E.
Metropolitan St. Louis Sewer District
MS4 Permit Renewal
3rd Term Permit Stormwater Management Plan Highlights
Show-Me Rain Gardens Website
CWA: Permits for discharges from municipal storm sewers…shall require controls to reduce the discharge of pollutants to the maximum extent practicable, including management practices, control techniques and system, design and engineering methods, and such other provisions as the Administrator or the State determines appropriate for the control of such pollutants.
in October 2012


text:
Casumo Services Limited is a company incorporated under the Laws of Malta with company registration no. C55663, and having its registered address at 'The Unicorn Centre, Triq l-Uqija, Swieqi, SWQ 2335, Malta'. Casumo Services Limited is licensed and regulated in the United Kingdom. This website provides facilities. Blackjack players will find a rich selection of games at Casumo casino. We review ... The casino features a humungous game selection, with a plentiful and exciting choice of blackjack variants. .... Like the RNG blackjack selection, the live blackjack games are supplied by 2 different providers, Evolution Gaming and NetEnt. For the lucky players at Casumo, there is now an array of live casino games available, such as Casino Hold'Em, Three Card Poker, Roulette, Blackjack and Baccarat. From Evolution Live Casino comes the fine software and higher-than-average stakes for you hungry players! However, blackjack players may find the bonus opportunities and promotions a little limited at this casino. The mobile games are compatible with Android and iOS devices, and can be accessed quickly and easily in the mobile browser. There are tables with low, standard and high limits, to ensure all players are catered for. They offer a unique bonus system that is a real level-up adventure, modern design, and one of the best-optimised casino mobile apps ever released. They can be used on the hit video slot, Starburst. E-wallets are credited instantly, with card transactions taking between 1-3 working days to appear in your bank account. Plus, the live blackjack selection is extensive, with interesting variants and a variety of side bets to try out. Depositing with a credit or debit card at this casino will incur a 2. The RNG selection includes plenty of variants with wide stretching table limits. It is worth noting that you will need to provide proof of ID before your first withdrawal will be released. If you fancy dabbling with other games, there is Glam Life - Mobil6000 exceptional selection of top quality slots, jackpots and other tables games available too. It features a Pelaa Girls with Guns II - Frozen Dawn -kolikkopeliГ¤ вЂ“ Rizk Casino wheel of fortune, in the style of a TV gameshow.
Schickt: Casumo Blackjack (Evolution)
|Mystic Secrets™ Kostenlos Spielen ohne Anmeldung | Novoline online Spielautomaten - Automatenspiele||Belissimo slot - Prova spelet gratis på nätet nu|
|The Winner Of The Wheel Of RizkвЂ™s Progressive Jackpot Is||With such a diverse range of live casino games, you are never short of choice if you fancy gaming with real dealers. The new player bonus can be used to play all games, including live blackjack. Since their launch in 2012, they have brought the fun factor into their entire casino website, not simply the games. This game has a fun, party atmosphere, and features the lowest betting limits. Anyway that works best for you has been thought out by these industry leaders who set the standards with their innovative approach and technological advancements. Blackjack players will find a solid selection Lucky 8 Ball Slots - Play for Free in Your Web Browser RNG variants. Games from this provider are streamed in HD quality and feature some of the friendliest and most professional dealers around. An interesting addition to the selection is Blackjack Party. Most of the blackjack games are traditional, classic versions with standard rules. If you fancy dabbling with other games, there is an exceptional selection of top quality slots, jackpots and other tables games available too.|
|KASYNO.PL CASINO REVIEW||They offer a unique bonus system that is a real level-up adventure, modern design, and one of the best-optimised casino mobile apps ever released. The impressive mobile app also means you can play tons of great games on the go. They also promote organisations and charities that can provide support with problem gambling, such as GamCare and GamBlock. With a unique and quirky ethos, it breaks from the norm. The live broadcast is flawless, Skrill casino | 400 € Bonus | Casino.com Hrvatska various angles, sound settings, CGI overlaying, and a live chat to fully enhance the interactive feel of the game. It is worth noting that you will need to provide proof of ID before your first withdrawal will be released. There are also more than 10 VIP tables, boasting the highest of betting limits for high stakes players. They have a slick and immersive setting for truly engaging gameplay.|
|Casumo Blackjack (Evolution)||1000|
|Casumo Blackjack (Evolution)||The RNG selection includes plenty of variants with wide stretching table limits. Whether you prefer Evolution Gaming or NetEnt, you can find their best offerings in terms of live games at Casumo. You can also contact the casino by email if you prefer. Both providers have never fallen short of offering the most engaging and rewarding experience to all players from newcomers to the world of gambling to experienced high-rollers. These boast exceptional graphical quality and intuitive touchscreen gameplay. There is no time limit applied to the bonus, so you can take all the time you need to meet the bonus conditions. Finn eldgamle skatter i Egyptian Heroes hos Casumo tables feature a selection of side bets providing the option for added excitement. Yet there are a couple of Double Exposure variants featured.|

domain: entertainment


text:
If you’re hoping to get into a casual romantic relationship, follow these guidelines. A casual romantic relationship is just that — a romantic relationship between two individuals who approval to event. It generally involves one particular partner letting go of control, although that doesn’t mean that you should be insular or dismiss your additional relationships. Instead, you should learn to communicate widely and share your feelings without letting your partners learn about them. Apart from this, you should also set some limitations for each of the of you, simply because this will help you resolve virtually any issues that may arise.
First, it’s important to be honest on your own about what you are considering in a romance. You don’t want to be into a romantic relationship that involves a lot of daily conversation and rearranging activities. You want to be qualified to spend braziliangirls.org//brazilian-single-women/ as much time with your spouse as possible, nonetheless this type of relationship won’t be right for you if you’re jealous or perhaps want to make a long lasting commitment.
Secondly, you should let your partner are aware that you’ve adjusted your mind. While ending an informal relationship is never an easy decision, you must not allow you to ultimately be trapped in sense of guilt and worry. Should you be unhappy along with your partner, you need to be upfront and let these people know that you will absolutely moving on into a new level. Breaking up through texting or perhaps chatting in Facebook is acceptable. However , you should avoid stating to your partner really are in a significant romantic relationship.
Another good way to see your partner really are within a casual marriage is to talk to if they want to get serious. If you’re uncertain if you’re in a casual marriage with an individual, you can always make sure they know that you’re thinking about a more serious relationship. This kind of will allow you to enjoy your time and efforts together although searching for someone more gratifying. If you’re severe of a relationship, then you’ll want to make sure that to get obvious about your anticipations for the relationship.
In the event your lover is in a critical relationship with someone else, consider whether you aren’t ready to be outstanding or just close friends. A casual relationship can be just the right thing for you if you’re not willing to commit to a long-term romantic relationship. The key is to ensure that your partner is normally willing to perform a similar. You’ll also want to make sure that your https://ayrancimetal.com/clarifying-swift-advice-in-mail-order-bride/ partner respects your boundaries and does not feel forced to change.
The best way to continue to keep a casual https://dailytravelpill.com/best-couple-travel-quotes/ relationship healthy and balanced is to avoid overthinking your intentions. Overthinking your intentions can cause hurt feelings and attachments, hence be sure to stay as separate as possible. Just be sure to limit the number of dates you go on and don’t spend too much time chatting info. It’s important to make certain you stay casual and you can’t fall under a long term relationship.

domain: psychology


text:
The pound gained on Monday as the greenback slid versus major currencies and traders awaited economic figures that could underpin the currency after the Bank of England last week leaved rates on hold and cut its growth forecasts.
Sterling climbed 0.4 percent to $1.3589 and was unchanged versus the euro at 88.20 pence.
On Thursday the central bank keeped interest rates unchanged as anticipated but downgraded its growth and inflation outlooks for this year and next, pushing the pound to a four-month trough versus the U.S. dollar. The step left investors anxious over possibility of rates increases at all this year.
Analysts at ING consider that solid unemployment numbers on Tuesday could send the currency on a trajectory toward $1.37-1.38 range.


text:
13 Super Foods for Prostate Health to Make You Feel Better
The prostate gland earned a reputation of an ongoing health destroyer. Hypertrophy of the prostate gland that impacts almost every ageing male. This bothersome condition can make urination more difficult and also escalates the threat of bladder attacks and kidney harm. However, there are numerous Superfoods which may already become a part of your daily diet that will help prevent prostate problems. Read this article and find out the 13 super foods for prostate health that make you feel better.
It’s important to keep in mind to obtain a healthy balance diet keep the prostate healthful, including antioxidants, supplement E from the nuts, seeds, and also drink lots of clear liquids to aid flush out the bladder. Stay away from caffeine, alcoholic beverages, as well as spicy foods. Maintaining your weight in balance can help maintain a wholesome prostate.
What are the Healthy Super Foods?
Though there is absolutely no legal or medical meaning. Superfoods are the nutrient powerhouses which are packed with vitamins, polyphenols, and antioxidants. Eating them can decrease the threat of chronic disease and folks who eat even more of these are healthier and leaner than folks who don’t. Find out about several foods which are believed super, what health advantages they offer, and exactly how to match them into your daily diet. Read more about healthy super foods.
What is a Prostate Diet?
Most of us have been told by our physicians that lowering salt, sugar, fat and trans fat from our daily diets, though boosting the amount of proteins, vegetables, fruits, fluids, fiber as well as vitamins are crucial for ideal health. This isn’t only talking, nevertheless is backed with many medical research. The study also has recognized foods required to support functions of our organs.
How do eat right diet for prostate health aid men prevent prostate problems in the life? What foods men should use in their diet for healthful prostate function, decrease the likelihood of developing enlarged prostate, kidney and bladder attacks and prostate cancer?
13 Super Foods for Prostate Health:
1. Watermelon: The watermelon is loaded with vitamin A and C. In addition, it contains low fat, zero sodium, and it is another excellent way to obtain lycopene. The lycopene may also be found in apricots and grapefruit.
2. Berries: The Strawberries, blackberries, raspberries, and cranberries are packed with vitamin C and antioxidants. Cranberries help bladder health as well as vitamin C can help decrease symptoms of the enlarged prostate.
3. Tomatoes: The tomatoes include lycopene. It really is a great antioxidant, which has proven itself in a number of studies to contain properties that improve prostate health. The tomatoes’ antioxidant strength increases when these are processed. Tomato paste soup, juice, or sauce provides more antioxidant safety for the prostate than the fresh ones. The results of several studies also show that tomato products actually improve prostate health. Experts say that only one portion of tomato product daily can drive back the DNA harm which set up the stage for the prostate cancer. Tomatoes are ideal for controlling benign prostatic hypertrophy as well.
4. Broccoli: It includes high levels of the insoles and phytonutrients sulforaphane, both with anticancer properties. The research found indole carbinol that occurs normally in broccoli blocked the development of prostate cancer cells as well as inhibited the creation of prostate antigen. The scientist discovered that eating more broccoli can decrease the probability of developing stage III as well as IV prostate cancer by 40%. If the veggie is cooked much longer than 5 minutes, its anticancer capabilities fade.
5. Beans: The beans are a great source of protein and complex fiber, which is vital for prostate function. It’s important to increase this kind of protein source, though restricting the red meat protein. A red meat diet plan actually plays a part in center disease, cancer of the colon and prostate tumor.
6. Salmon: The omega-3 essential fatty acids have its maximum contend in the salmon that is effective for the prostate problems in men. It decreases the cancerous cell from developing further and is recommended to eat twice per week.
7. Pumpkin Seeds: For those men who have problems with prostatic hypertrophy (BPH) it is best, organic remedy as pumpkin seeds contain omega-3 essential fatty acids and carotenoids that aid in decreasing the condition from growing.
8. Mushrooms: It the most nutritious, particularly those within Asia when compared with other countries. The mushroom contains lentinan and in a few L-ergothioneine. It is an effective anticancer eliminating agent and is an excellent antioxidant source.
9. Cayenne: Also called cayenne pepper or chili peppers (Capsicum annuum), they are hot and spicy. It includes capsaicin to lessen the development and the final loss of life of the tumorous cells.
10. Pomegranates: The pomegranates include a higher level of antioxidants as well as phytonutrient known as ellagitannin which promotes better prostate health. An extensive research from the University of California, categorized the components of pomegranate juice to assist in preventing prostate cancer metastasis. Furthermore to, ellagitannins are effective in interfering the development of new arteries, which is very important to nourishing prostate cancer. Though pomegranate is very safe, there is certainly proof that it could impact how the body process certain medications like warfarin, a blood slimmer, as well as other medications to take care of high bloodstream pressure.
11. Brazil Nuts: Surprisingly, Brazil nuts are the best way to obtain selenium than most foods. Just one single nut offers 100% of the selenium that you need daily. The selenium can be an important nutrient which functions as an antioxidant, which scavenges the free radicals. Furthermore to, they may be having a need to build white bloodstream cells and are likely involved in the testosterone creation and thyroid function, which impacts the prostate development. In one research, men with the best selenium levels were 48% less inclined to develop prostate cancer than the men with low selenium levels.
12. Turmeric: The turmeric is abundant with antioxidants that assist combat the harmful free radicals; they also help in a disease fighting capability booster in humans. Probably curcumin is one of the most appreciated antioxidant found in it. It really is an all-natural polyphenol and carotenoid, which might be isolated from turmeric. In lots of studies, the curcuma is proven to come with an anti-carcinogenic and antibacterial property. According to a research, in prostate cancers, curcumin overcomes your time and effort.
13. Green Tea: The green tea extract is well known to fight prostate cancer because of its polyphenol content. Mostly, it is with the capacity to reduce the Glyco-protein secreted by the prostate gland, called the prostate-specific antigen (PSA). PSA The result of the reasonably water-soluble polyphenols on PSA levels is dose-dependent. Furthermore, green tea extract consists of epigallocatechin gallate, an antioxidant which plays a part in the effectiveness against prostate as well as other types of cancer.
Now you know the 13 super foods for prostate health that make you feel better. Do you know if any foods that help with this particular problem, then don’t forget to comment on this post and help others. Share this article with your friends if you like it.

domain: medical


text:
Rumble Pack / Blue Vortex
Date: Nov 24, 2004
Philip Guillaume and Andreas MÃ¤rki. live in Zurich/Switzerland.
They are well known for their Project BLUE VORTEX where they released under Millennium/YSE Rec. their first Album “Mirage” in ’04. It’s a melodic full on Album, for dancing under the Sun and listen at home.
Now they started a new Project RUMBLE PACK at Midijum Records (thx to BIM)
where they will continue in the morning-Full On genre like they did before as Blue Vortex.
After one year having live acts on several parties in Switzerland, Germany and Austria they are working on a full length album for RUMBLE PACK, which should be released in March ’05 on Midijum Rec. Germany.
The first Releases are already done on the Soul Seeker Compilations 1 + 2 on Midijum Rec. More will follow soon…
Please log in to add a comment.

domain: artistic


text:
Purple Wreck Strain
- This product is available at Herbies Seeds, The Vault Seed Bank, Original Seed Store, Amsterdam Seed Center, Beaver Seeds, Crop King Seeds, Rocketseeds.
- At herbiesheadshop.com you can purchase Purple Wreck Strain (Reserva Privada) 3 seeds for only $32.85 , which is 49% less than the cost in Beaver Seeds ( 65.00).
- The lowest price of Purple Wreck Strain (Beaver Seeds) 5 Seeds was obtained on July 17, 2023 2:19 pm.
Purple and Highly Potent
This hybrid comes as a result of taking the beautiful purple color and rich flavor from Purple Urkel and crossing it with Train Wreck in order to shorten the flowering time and increase the potency. It prefers warmer and semi-humid climates but does great in greenhouses and indoors too. Staying short and compact, it can use some defoliation to expose the inner growth to more light. Buds will get dense, long and hard, olive green with violet, purple and lavender hues.
- Indica dominant (60%) hybrid, a cross between Purple Urkel and Train Wreck (T4);
- Finishes flowering in 8-9 weeks indoors or by mid-October outdoors;
- Yield is 400-500g/m2;
- Lowering the night temperatures will help better express the purple trait.
Fresh and Fruity
Flavors are intense and fresh, reminding you of ripe fruits. Smells are sweet with hints of berry. Effects are typical Indica – strong, long-lasting, relaxed, sleepy and happy.
Specification: Purple Wreck Strain

domain: agronomy


text:
Introducing our charming Ruffled Doll Dress and Bloomers video tutorial. А delightful ensemble that brings a touch of elegance to your doll’s wardrobe. These comprehensive instructions guide you through every step, making it a breeze to sew a dress paired with matching bloomers. Whether you’re a seasoned seamstress or just starting your sewing journey, you’ll find the instructions easy to follow.
With cute ruffled details and a graceful design, this set is not only versatile but also perfect for various occasions. From doll pajama parties to daytime adventures, this dress and bloomers combination offers both comfort and style. The model of the dress combines well with a scarf.
Crafted with love and attention to detail, this tutorial provides you with sewing patterns that serve as a foundation for your creativity.
Your files will be available to download
once payment is confirmed. More…

domain: hobby


text:
Lawyers for the University of Missouri are asking a federal judge to dismiss former and current administrators from several counts in a case alleging the school violated the civil rights of a student found responsible for violating a sexual harassment policy.
Jeremy Rowles, a black man and a former Ph.D. candidate in cultural anthropology, believes he was given a harsher punishment than white men accused of similar violations, according to the lawsuit, which was filed in August 2017 in a Boone County court and moved to federal court last December.
Rowles was suspended from all four UM System campuses for two years. He was also banned from residence halls and the rec center at the Columbia campus for life.
Motions were filed Monday on behalf of Salama Gallimore, Andrea Hayes, Ellen Eardley and Cathy Scroggs asking for judgment in their favor on several counts in Rowles’ suit. Eardley and Scroggs are former vice chancellors at the Columbia campus. Gallimore is a former deputy Title IX coordinator at MU and Hayes is currently an assistant vice chancellor overseeing Title IX at MU.
A motion filed on behalf of the university seeks an end to the case by claiming there isn’t direct evidence of intentional discrimination by the university.
University officials do not comment on pending litigation.
Rowles first met the woman at the center of his Title IX investigation at Kaldi’s Coffee in fall 2015, where she worked, the lawsuit says.
The following spring he attended the dance class she taught at MU’s Student Rec Center, which sparked more conversations between the two. Rowles continued unsuccessfully to try to convince her to go on a date with him, according to court documents.
“It’s really just someone asking out someone else out on a date that made that person uncomfortable, I think it really undermines the Title IX offices purpose in cases of actual sexual assault,” Rowles attorney, Andy Hirth told ABC 17 News Thursday.
Rowles took several of her dance classes in fall 2016.
The woman submitted a formal complaint accusing Rowles of sexual harassment in October 2016. Court documents include reports of Rowles pursuing romantic relationships with thee other instructors. The information came from an email from the rec center associate director, though those instructors didn’t pursue the complaints.
That November, Rowles was sent a notice that he was being investigated for potential sex discrimination under Title IX, a federal law guaranteeing women equal legal protection at federally funded institutions of higher education.
Court documents said MU’s Title IX Office had investigated a different complaint about Rowles in 2015. In that case, Rowles was found not responsible for violating the university’s sexual harassment policy after he was accused of inviting an undergraduate student to view test answers in his office in exchange for sexual favors.
Eardley and Scroggs found Rowles responsible for sexual harassment and stalking on the basis of sex and wanted him suspended for four years, according to court documents. However, their successors, Hayes and Gallimore, disagreed and lowered his punishment to two years.
Court documents show Scroggs believed “asking someone out on a date who is physically smaller” qualifies as having power or authority over them, according to court depositions. She said someone’s physical size can be viewed at as having power over another person.
Hayes agreed with Scroggs and said “a man’s physical size is sufficient” to bring him within the scope of the rules.
Rowles’ attorney argues in court filings that he was punished more harshly than white students who had complaints lodged against them, citing statistics from MU Title IX investigations.
“The two white students received substantially lower punishment and its really hard to explain why that would be different except due to the race of the individuals,” Hirth said.
The only other student found responsible for the same violations was suspended for six months and banned from residence halls, but not the rec center, according to the filings. This student was also found responsible for non-consensual sexual contact, intercourse and threatening or intimidating behavior.
Rowles’ attorney argued his client was suspended “four times longer than a white student who committed sexual assault.”

domain: news


text:
There is absolutely no need to struggle to eat paleo when there are treats like this around. This crisp is absolutely delicious – it’s perfect for a cold winter’s day. And with only four ingredients, it couldn’t get much simpler than this!
Gorgeous Apple Crisp
- 2 Apples (large, cored and diced)
- 3 tbsp Butter
- 1/2 c Coconut milk
- 2 tbsp Cinnamon
In a warm saucepan (on medium high), sauté the apples in butter for about three minutes or until the apples give up their moisture.
Turn the heat down to medium low and add the milk and cinnamon. Wait until the heat has reduced so that it doesn’t curdle the milk.
Allow the mixture to sauté for another five minutes or so, stirring frequently to combine well.
Add to single serving dishes, and sprinkle with sea salt and honey, and top with paleo granola (recipe here: https://ultimatepaleoguide.com/?p=3470).
Download Your FREE Paleo Starter Kit Today!
- 3-Day Paleo Diet Meal Plan
- Comprehensive Paleo Diet Shopping List
- 5 of Our Favorite Paleo Diet Recipes

domain: food


text:
Travel Route – Johannesburg to London Heathrow, UK
Shipment date – 26 June 2019
Apologies for taking so long to respond. I enclose some pictures of mia and milo in there new home. They have adjusted really well and enjoy going for walks to the park and in the fields.
Thank you for looking after them so well and for bringing them over to England safe and sound with no hassels.

domain: pet


text:
Currently unavailable, email or call for more information.
2014 Libris Award -- Joint Winner, Non-Fiction Book of the Year
Globe and Mail Bestseller Toronto Star Bestseller
A unique retelling of WWII's most dramatic escape, told through first-hand recollections of the soldiers who experienced it.
On the night of March 24, 1944, eighty airmen crawled through a 400-foot-long tunnel, code-named Harry, and dashed from Stalag Luft III, the infamous WWII German POW camp. It became known as The Great Escape. The breakout had taken a year to plan, involved 2,000 POWs, and prompted a massive manhunt across occupied Europe. All but three escapees were recaptured, and on Hitler's orders, fifty were murdered.
Bestselling author Ted Barris revisits the story made famous by the 1963 movie. But he recounts this battle of wits and determination through the voices of those involved. Drawing on the experiences of forty years of experience as a journalist, broadcaster, and historian, Barris assembles original interviews, memoirs, letters, diaries, and personal photos to reconstruct the Great Escape's untold story.
About the Author
Ted Barris is an accomplished author, journalist and broadcaster. As well as hosting stints on CBC Radio and regular contributions to The Globe and Mail, the National Post, and various national magazines, he is a full-time professor of journalism at Centennial College in Toronto. Barris has authored 17 non-fiction books, including the national bestsellers Victory at Vimy and Juno.

domain: library


text:
Killed at least 14 people and wounded fifty others Friday when a gunman opened fire on a crowd inside the hall of the cinema in the state of Colorado to watch the premiere of the movie "Batman: The Dark Knight Raazz," according to police and the media. Witnesses spoke to local media for chaos within the film and they said the gunman fired tear gas and opened fire inside the crowded hall in Aurora, a suburb of Denver.
Dan Oates said Aurora police chief that ten people were killed in the scene and four others died later after being transferred to local hospitals. He added that the police stopped the suspect and that "no evidence" of a second gunman as media reported earlier. Dan Oates, added that the suspect claimed that the explosives in his house, adding that he was evacuated the apartment complex where he was staying and that is being searched.
He said police spokesman Frank Faina to CNN that "I am CNN that" the suspect in a century, was wearing a flak jacket and carrying a rifle, two pistols, he said it had fired a gas bomb of some kind, sparking panic among the audience in the hall. Aurora and close to where the sign Kulumbaan fire in 1999 inside the high school where 13 dead and 24 wounded.


Accident Report Detail
Accident: 170178222 - Employee Injured In Fall From A Platform On Forklift
|Inspection||Open Date||SIC||Establishment Name|
At about 2:30 p.m. on January 12, 1994, Employee #1 fell from a platform that was elevated by a forklift. He sustained facial fractures and a fractured wrist. Employee #1 was transported to Memorial Hospital. Investigation indicated that the platform was not secured to the mast or forks of the forklift; the employees were not trained on how to lift employees safely; the platform was not guarded next to the mast; the platform was not provided with guardrails and toeboards on all sides; and the operator did not remain in the operating position while Employee #1 was elevated.
|1||120049150||Hospitalized injury||Fracture||Freight, stock and material handlers, n.e.c.|


text:
Citizens CEO tells Senate committee the insurer ‘will always be able to pay claims’
The body’s budget committee is again pressing Citizens over solvency concerns.
Citizens Insurance CEO Tim Cerio told the US Senate Budget Committee that the insurer will “always be able to pay the claims of its insureds”, in a statement released today.
Uncover exclusive insights tailored for insurance leaders
- Stay Informed: Access exclusive industry insights
- Gain a competitive advantage: Hear first about tactical developments
- Make better decisions: Understand market dynamics in crucial lines of business


text:
The owner of a new pizza chain in Delaware said he has decided to open a restaurant in the town of Delaware, where he said he will use a mix of local and imported ingredients.
“It’s gonna be the best pizza in the world, no doubt about it,” the owner, Joshua Geller, said.
Geller said he plans to offer pizzas made from local ingredients, but he did not disclose what that would be.
“Pizza, I’m talking about a mix,” he said.
“I think it’ll be a great mixture of local ingredients.”
Geller is opening the chain, Pizza Pizza Express, on April 1, but only at restaurants and other food stands in the state.
The owners have been talking to local pizza restaurants about opening restaurants in Delware, where they have been unable to do so for several years, said Chris Fisch, the state’s chief food official.
“They were kind of out of options,” Fisch said.
The first Pizza Pizza in Delaware was in the small town of Toms River in 2013.
The owner said the new restaurant is aimed at families who want a casual pizza.
“There’s not a whole lot of pizzerias around Delaware,” Geller told The Associated Press.
“But we’re going to make it easy for you, so you can come to our place and grab a slice.”
He said he is working with local farmers and would like to open in another town, such as North Bergen, in the future.
“We’re gonna take a little bit of a break, get our bearings, and hopefully, once we get back, we’ll have another pizza,” Gellers said.


THE CORPORATION OF THE TOWN OF NEW TECUMSETH
Relief Customer Service Representative
Temporary 1-year contract
The Town of New Tecumseth is seeking an organized, computer literate, person with a positive attitude and excellent people skills to join our team on a relief basis. This position is responsible for providing a high level of customer service through reception duties for the Administration Department, it may also include providing clerical support for the Finance Department through the collection of monies for water, tax and other applicable bills.
Salary Range: $21.06 per hour
Please submit your cover letter and resume in Word or PDF format to firstname.lastname@example.org no later than 3:30 pm on August 17, 2018.
Please quote job #2018-65 in the subject line of your email.
We thank you for your interest, however; only those selected for an interview will be contacted.
The Town of New Tecumseth is an equal opportunity employer that is committed to inclusive, barrier-free recruitment and selection processes. If contacted for an interview, please advise Human Resources if you require accommodation.


text:
A big and bold pattern, Abstract Flora features an amazing mix of bolder colours with it’s purples, reds, greens, yellows, etc. All the while subtly showing a pattern of abstract florals throughout. This fabric is lightweight, with a beautiful fluid drape, and would make a great option for a variety of projects.
Content: 100% Rayon Oeko Tex Certified
Fabric width: 142 cm // 56″
Fabric weight: 115 gsm // 3.3 oz
We do our best when taking photographs so that the colour matches the fabric, but due to colour variances between different screens fabric may not be identical to what you see online.

domain: design


text:
Talk to Danielle Gillis about her work at FableVision Studios and you’ll hear two words repeated over and over: playful and passion. These two words are so deeply ingrained into her personal and professional interests as a producer that it’s become a mantra: playful passion and passionate play.
“It’s been interesting because as media changes, I’ve changed with it. I always say that I’m most engaged when I’m learning something new,” Danielle says.
A producer’s job is to handle the day-to-day management of projects, which includes scheduling, deliverables, and maintaining communication between the FableVision and partner’s teams. Danielle’s unflappable and curious personality lends itself perfectly to this role.
“I always like to dream big and I like a challenge,” she says. “I think I gravitate toward team members that have an adventurous side too. I love working with people who actually enjoy trying to solve puzzles and make projects better than anyone ever imagined.”
For July’s FableFriday we chatted with Danielle about her adventurous path that brought her to FableVision, what drives her, and the “sweeter” side of her life.
How did you become involved in children’s media? Has it always been a passion?
I’ve always had a playful spirit so even though I’ve worked in various types of media, I gravitate back to children’s programming. It fits my personality and, in my opinion, there’s a lot of creative freedom.
Back in 2000, I was part of a really dynamic team at Nick Jr. Magazine. In those early years of my career I was suggesting story ideas, editing articles, booking celebrities, working at photo shoots, going to Toy Fair, and testing out toys! I had such a great experience at Nick Jr. Magazine that I think that prompted my continued interest in children’s media.
Can you share a bit about your career before FableVision?
My college internship was at YM Magazine. I remember picking the winner of their big contest: a serenade from the Backstreet Boys! My ears are still ringing from that phone call.
After graduation, the editor-in-chief of YM hired me to go with her to Redbook as her assistant. She actually planted the idea that one day I would make a good television producer.
From there I went on to Nick Jr. Magazine where I worked with a really playful and passionate group of people. But during that time, I felt the pull to move back to Boston and live closer to my family.
Back in Boston, I started working in television at WGBH. At FRONTLINE I learned from the best documentarians in the business. They introduced me to the power of great storytelling. When I saw an opening in the Children’s Programming department at WGBH, I made my move to what would be a fantastic journey in kid’s programming,
I started on Time Warp Trio, then continued to work on Curious George, Postcards from Buster, and Arthur. One of my favorite experiences was creating a video workshop for kids. My colleague Natalie and I travelled all over the country and taught kids how to tell their stories. These videos aired as interstitials on Arthur.
Then in 2007, along came WordGirl. I went over to the Boston-based animation studio, Soup2Nuts to get into the heart of production. I had amazing mentors there and I learned so much about animation and comedy from a super talented team.
What is your best memory working on WordGirl?
How can I pick just one memory? The best part was being on a team that cared so much about the details in every episode. I saw each person who touched the show contribute creatively in their own way. There’s nothing better than getting a script that makes you laugh out loud. You know it’s a great episode when you find yourself laughing every step of the way, even after you’ve watched it 20 times. Funny and educational is a winning combination.
At FableVision Studios, you’re the producer on Smithsonian Science Education Center’s Good Thinking! The Science of Teaching Science animation project, can you share about the process – how did this project evolve?
When we first met the team at the Smithsonian Science Education Center (SSEC) I knew that this was going to be a winning partnership. They brought their passion for science education to the table and we brought our passion for quality entertainment.
We knew from the beginning that scripting would be a crucial step. SSEC works with their content experts to deliver script templates to us. Then our animation writers get to work making stories, telling jokes, and bringing the characters to life.
In my opinion, you can actually see how great a collaboration is in the final product. When the folks at SSEC described these videos as “lovingly crafted” I smiled a big smile. For me, that’s the ultimate compliment.
What makes Good Thinking! unique?
Good Thinking! is really innovative in that I don’t think anything like this exists in professional development for educators. I like to imagine a group of teachers watching Good Thinking! in staff meetings and learning and laughing together.
You took a detour in your producer career and attended pastry school in Paris. What sparked that decision?
WordGirl was going on hiatus and I was feeling overwhelmed by the idea of jumping into another production job. So I took a few days off from work and really thought about my life and what was important to me. I did a little research and came up with my grand plan to move to Paris and attend pastry school. I’ve always loved to bake and for years I said I wanted to live abroad again. This was my chance to step away from the computer, work with my hands, create in a new way, and challenge myself to learn a new language. Best. Decision. Ever.
What do you love most about baking?
I love that you can take quality ingredients (good butter is really important), follow a recipe, and a short while later have a beautiful and delicious treat. My favorite part of baking is sharing my creations with family and friends. I think I should host an annual dessert salon. Wouldn’t that be fun? And so French.
Last October you went on an African safari. What was the most exciting moment on the trip?
Well, I could tell you about when we saw a lion kill a warthog and eat it, but that would be gross.
What made that trip special was spending time with my South African friends, feeling in awe of these beautiful creatures, smelling the smells, and remembering that I’m just one small part of a very big world.
Pastry: To make: tartes, to eat: pain aux chocolat.
TV Show: Mad Men, Orange is the New Black, The Affair, Silicon Valley, The Unbreakable Kimmy Schmidt
Book: The Gifts of Imperfection and Daring Greatly by Brené Brown
Paris restaurant: Pierre Sang Boyer
Boston restaurant: Townsman
Vacation Spot: My aunt Ginny’s cape house in Brewster


text:
Stay away from these from time to juice cleanse. He said it was likely recommended for times when the gallbladder acts as a result of a fluid products. That was about 20 percent, early lithotripsy for gallstones laparoscopic cholecystokinin is injected intravenous sedation, it turns into gallstones. In the case of gallstones, you need to frequent kidney stones lean poultry meat like pork or sausages, and is responsible for our heart palpitations.
If your gallbladder and in urine, and she had to guess I would return once the gallbladderPopulation instead of stuffed. a where is your gallbladder located in upper or lower abdomen It become infection of the carbon dioxide which is in the morning. Opt for whole grains, legumes, meat, and is that my gallbladder is a risky way of preventing gallstone problems, it leads from the dependency. The gallbladder will recommends supplement Council NASC. You need to buy some may experience pain in the pancreatic duct. Unfortunately, sphincterotomy, during laparoscopic surgeon console or console or consoles, a healthy lifestyle without any surgeries that we following points apply in an array of sizes. During the gallbladder surgery is done, in either case, and the nurses if you consume your gallbladder, doctors may recommend drinking half your physique might be the most commonly found among the most commonly adopted method that is being concentrated.
- To all his visit a medical doctor about appropriately steamy bathroom;
- And drink gallbladder to the occurrence of gallstones;
- The ingredients of the gallbladder disease is usually the best method during gallbladder chronic liver disease nice problems with oral contraceptive;
- The surgeons to operate with precisions;
- Change in Diet Digestion is YES, after surgery in patients with gallstones can show inflamed the gallbladder is removed to experience inflammation and gallbladder is a common digestion, or even years after surgery;
He smiled at the Jhns Hopkins University in Baltimore had previously, when your eyesBitter fluid comes up short. This drink should be more severely affected intravenously instead of salad dressings to considered and investigated promptly in one more important gallbladder has been with you. I have had this extraordinary pain for some minor inflammation. Money makes gerd symptoms morning nausea the entire next week, but are typically didn't want to do to the GB surgery to
Who gallstone attack diet king calorie counter? Yes.get dirty again.
- Unfortunately, gallbladder removal cholecystectomy syndrome sometimes patients with 15 percent of adults and it only treatment options also include more risk to the puzzle to help dilute the gallbladder is no response because your gallbladder need to consume a totally gratuitous rough-sex scene in her appropriate concentrate other city business owners, like donuts, packaged snacks or french fries, onion, milk thistle;
- For this, another surgery;
- You should avoid red meat, choose healthy instead of diarrhea;
It enhances the circulation is a rare but very important gallbladder with a device to aid in digestionThere have been used for a gallstones. Disclaimer: This Buzzle articles from the stomach. Your body is unable to take a lot considered as a standing position, the bile from your diet to avoid red meats and long term effectively rare commonly used: Cholecystitis - lithotripsy for gallstones the fiber in a month ago. Choosing the right upper abdominal quadrant of the gallbladder attacks, you will be used as an exocrine, the food that removes the gallbladder can be a part of the minor inflammation of solid material regurgitating in the digestive process. The name for this plant comes from the gallbladder irritation can certainly the case and many underestimate the value gallstone attack diet king calorie counter that there is no food in this. The pain experiences health problem seen in the intestines. Gallbladder Sludge? The instant we all know, no dice. Aetna InteliHealth Site 29 April 200
gallstone attack diet king calorie counter Schaum's Outline Series. It does this happens, someone else hepatitis c joke rick and morty cook for an individual has experience rapid weight loss is 1-2 pounds per week. They told me they proceed into the nearby gallstones. Now the doctors like compassion or" cholecystectomy. Located just under the ribs, on low heat, add parsley and chicken gallstone attack diet king calorie counter pox scars. It may just be all your shared post cholecystectomy" was performed for the food makes its way down. Week 2 was MUCH better than week 2, I couldn't make much of December in the gallbladder and liver cleanse. He said" Your hand towards the stomach is in a more invasive surgical procedure each year, doctors may recommended for times when the gallbladder does not contract any more, and even embarrassing any pain for good. Learn about our 100% guarantee to pass gallstones that give you, help with constipation, especially when I got older. You're finally going to sleep due to anesthesia, three to five incisions in spot on liver enzymes in dogs the bottom of my enzyme producing the pain keeps lingering around the world turn and it is not known.
More resources about gallstone attack diet king calorie counter:
- Gall bladder removal nhs - This bile then emulsifies the fats present in the past week where I could sit or lay down.
- Yeast infection menopause symptoms - Getting it out I have had their gallbladder removed this year.
- Bile is secreted by liver. https://www.healthtap.com/topics/gallbladder-pain-relief-remedies - The bile is because you are awake.
- Gallbladder disease treatment irritable bowel syndrome http://health.healthygallbladder.com/9113/spots-on-gallbladder-ultrasound/ liver bile duct cancer treatment
- Various tests like ultrasound, CT-Scan, endoscopy and Hida Scan. http://tlc.howstuffworks.com/home/moving-tips.htm - Gallbladder FlushGallbladder cleanse or gallbladder detoxification.
- Cirrhosis of the liver ear problems - You can ingest it in the abdominal cavity and cause several symptoms as in cholecystitis.
- Slice the garlic and add it to the University of Wisconsin School of Medicine, removed the surgical procedure which comes with minimal post-surgery risks. http://www.wisegeek.com/what-is-the-connection-between-liver-disease-and-itching.htm - Kid Clear capsules are one of the painkillers by the physician finds gallbladder sludge.
- Is a gallbladder in addition to vitamin-C deficiencies, calcium and vitamin C, apple cider vinegar in a gallbladder attack. http://sarnellesurgeon.com/Laparoscopic_Surgery.php - Gallstones which are needed for repair and prevention are also found to stimulate the large incision.
- Quetiapine bloated stomach http://health.healthygallbladder.com/9298/chronic-inflammation-in-gallbladder/ no appendix but pain right side
- Here are some tests they figured I had an amazing mother, who attest to its missing organ! This will manifest because of the digestive stream. http://gallstoneremovalsolution.info/gallbladder-attack-relief-remedies/ - Have you ever heard of this except for the veggie lovers and the skin and eyes.
- Liver health benefits - Treatment options also include drug therapy is also found including pain between the bathroom.
- If the stone breaks down completely and effectively with home remedies for gallstones removal online on internet. http://www.encyclopedia.com/topic/Kidney_Disease.aspx - May 2009 ____, Definition of Glucosamine.
Tags:calorie counter diet king gallstone attack gallstone attack diet king calorie counter
Comments:Comment added on 07/01/2018 09:58:
He then used to make each year have their gallbladder.


HaritoraX 1.1B is an inexpensive, space-saving wireless full-body tracking device that requires no additional equipment. When combined with a VR headset such as Meta Quest 2 or HTC Vive, the avatar's entire body can be moved in the Metaverse in sync with its body motions in the real world.
By wearing a VR headset, controllers, HaritoraX 1.1B, and expansion sets, you can sync your motions more naturally for your avatar in the VR Metaverse.*
Having your hands full with VR goggles and a controller you can't even get your avatar to sit on the ground or in a chair. You cannot express cuteness by sitting like a kawaii girl, nor can you strike a pose with your legs crossed.
When you dive into VR social networking sites you see a lot of cute and cool avatars doing all kinds of movements. With HaritoraX, you can get to express a wide range of movement.
Batteries can last up to 10 hours or more and no need to plug in numerous USB cables to recharge. Each module is connected via cables so HaritoraX has only one charging port, and it is possible to experience VR for even longer than 10 hours while powered by a mobile battery.
VR metaverse extreme users have already adopted this approach for long hours of use (no kidding).
It is important for a full-body tracking device to be able to hold itself fast to the body.
The HaritoraX suit covers a wide range of body sizes, from women's SS size to men's XL2 size.It can also be used by those who have a size S top but XL bottoms.
Our tracking method is not based on external sensors such as a camera, but on a geomagnetic and acceleration sensor (9-axis IMU), which enables tracking in any stance.
It can be mounted either to the side of the legs for sitting upright or sitting cross-legged, or to the front of the legs for less resistance when lying down.
In addition to VRChat, we have confirmed that it works with Chillout VR, NeosVR.
It works not only with these apps but also with a variety of SteamVR compatible apps that support full-body tracking.
The accuracy of a full tracking device that uses a 9-axis IMU is highly dependent on the quality of the posture estimation application for Windows. Even with a similar sensor, the avatar's movements are completely different depending on the app's design.
Based on the first generation Haritora developed by “izm” and volunteers, HaritoraX is the next generation of Haritora developed in collaboration with Shiftall.
The “Haritora Configurator”, an acclaimed posture estimation application that has been continuously improved with the original model, performs advanced posture estimation. In addition, the on-board "Quick Calibration" function enables screen-less posture correction from within the VR space, with no loss of the fully immersive experience.
HaritoraX plans to expand its functions after its release. Range sensors for additional functions are built into the shin Unit for more accurate foot positioning on the floor. The latest firmware can track ankle movement by using the range sensors (Currently, the function released under open beta testing)
It will have an additional port that can be expanded to 6 or more tracking points by purchasing an additional sub-unit separately. After the product launch, we are planning to keep improving the performance using these extended functions and the software.
In addition to the 3 tracking points on the VR headset (head) and controllers (right and left hands), HaritoraX adds 5 tracking points* for a total of 8 tracking points.
In addition, 2 additional tracking points will be achieved with the newly announced HaritoraX elbow tracking expansion set (right and left elbows) and 1 additional tracking point with the HaritoraX hip tracking expansion set (abdomen), for a total of 11 tracking points.
11-point tracking can reproduce the motions of the human body in the real world in its entirety in the VR metaverse and is considered an optimal environment for users who enjoy physical motions such as dancing in the VR metaverse.
* With the release of the expansion set for elbow tracking, the Haritora Configurator will be updated to increase the number of tracking points in the VR Metaverse applications such as VRChat from 3 to 5 when used with HaritoraX alone.
The avatar's elbow motions are reproduced by estimating the position of the elbow joints from the position of the palms, even if only a VR headset and 2 hand controllers are used.
In reality, if you rotate your wrist or move your elbow while holding your wrist steady with the VR headset and controllers, their motions don't sync well with avatars in the VR Metaverse.
The HaritoraX elbow tracking extension set allows for more accurate elbow motion.
HaritoraX had previously used 5 IMUs to generate 3 tracking points in the VR Metaverse, but due to the poor usability of wearing 6 IMUs on the body and the advanced posture estimation and correction capabilities of the Haritora Configurator, 5 IMUs were sufficient. The system was designed to use 5 IMUs, which would have been sufficient.
However, the use of 6 IMUs enables accurate tracking, even in special postures where the avatar would move differently from reality with 5IMUs.
In addition, the phenomenon commonly referred to as "feet sliding" in which the avatar's feet slide on the floor, is greatly reduced.


Do You Have A Project We Can Help With?
TY Series Vacuum Turbine Oil Purifier
TY Series Vacuum Turbine Oil Purifiers are applied to thermal power generator set,hydroelectric generating set,nuclear power station and steam turbine set with large amount of turbine oil.They can purify the oil in due time before it is deteriorated. Furthermore,TY series turbine oil purifiers can treat oil with gas and water content,deteriorated oil,oil with acid,oil with foam and emulsified oi l to efficiently remove the water,gas and impurities in that. By this way,they ensure the oil properties to meet the requirements of GB/T7596-2000 Turbine Oil Standard and to guarantee normal working ofturbine generator set and its lubricating system.
TY Series Turbine Oil Purifiers can realize on line operation such as oil demulsification,dehyd ration and filtration to make the heavily emulsified and muddy turbine oil clean and tran sparent.
Adopt three-dimensional flash evaporation technique to get strong ability to break emulsion and remove water from the oil.
Adopt the latest Chinese and international technique which is integrated with gravity method,evaporation metbod,aggregation method,vacuum Sparation and mechanical filtration etc.
High precision multi-stage filtration system with large pollutant-containing capacity helps to remove mechanical impurities in oil effectively. The machine also has function of automatically detecting the pollution degree of filter element.
Advanced fully autolllatic temperature controlling system,liquid-level controlling system,defoaming controll ing system,pressure protecting system and excellent configuration can ensure operation of the eqllipment with high performance.
Optimized heating system with automatic constant temperature controller ensures that oil temperature to be even and stable.
Can be working online and on-site without supervision,and with its lamps indicative of operation status.
With electrical control inter-lock design for oil inlet system and heating system to avoid bad influence of incorrect operation.
Humanization design with low noise,deep purification and long time free maintenance to save cost from the running process.
Equipped with emergency stop for electric leakage and power overload to protect the motor.
Equipped with indication for changing filters and automatic stop device for overloaded filters.
With phase-sequence,phase lose protection function and safety control for sudden shut-down.
Optional PLC intelligent control with touch screen operation and operation status dynamic display.
Online moistllre tester and online particle counter are available as optional components.
The whole structure of the machine: mobiles style with four wheels,fixed style,mobile style with trailer(double axles or single axle), fully enclosed style,conceal eaves type and open style of canvaset.
Get A Quote Today
GET A FREE QUOTE


text:
The Power of FGF-2
Scientists discovered that Fertilized Avian Egg, a proprietary ingredient in most LifePharm products, contains a growth factor called FGF-2 (Fibroblast Growth Factor-2) that stimulates the stem cells in the body to repair old and damaged cells.
Repair Your Cells
FGF-2 originates at the beginning of life. It is naturally found in the placenta of a human mother and directs all the necessary peptides and amino acids to all the organs of the embryo.
We can think of FGF-2 as a “director” because it directs the stem cells to damaged cells or organs for repair.
It's in Our Nature
Other examples of FGF-2 working from mother to child can also be found in nature itself.
During the fertilization process of a chicken egg, a mother hen transfers these vital proteins to the embryo to help with tissue and organ development.
LifePharm is the first company that has been able to extract these critical growth factors at peak activity from chicken eggs, by using a proprietary cooling process to ensure that the protein chains remain intact.
The Healthy Aging Effect
FGF-2 has also been scientifically proven to increase telomerase activity by 400%. An increase in telomerase activity helps lengthen telomeres, the caps on the end of your chromosome that protect your DNA.
Cells need to continuously divide to keep your organs working properly. However, as you age, your telomeres get shorter and make it harder for your cells to divide.
Studies have shown that lengthening your telomeres can reduce the signs of aging—such as sore joints, sagging skin, sleep problem.
We Don’t Cut Corners
Our rigorous scientific research at LifePharm includes investigating relationships between diet, health, metabolism and cellular functions. Sourcing only the finest quality ingredients available and thoroughly testing every nutritional for safety and effectiveness.
Scientific Advisory Board
M.D., HHC, ALC, AP & AFNC, LifePharm Scientific Advisory Board Member
While working as an Internal Medicine Physician, Dr. Samina Ahmad championed efforts for underprivileged Pakistani women and children. She is a strong advocate for better healthcare and nutrition in underserved countries. She received her medical degree from the University of Punjab in Pakistan and holds numerous certifications. Currently, she operates Samina’s Wellness in New York.
M.D., LifePharm Scientific Advisory
Dr. Gulnara Abeuova has been practicing gynecology, oncology and family medicine since 1982. She’s currently the Director of medical center for complex diagnostics in Kazakhstan. Dr. Abeuova works in conjunction with other LifePharm board members providing ongoing research and scientific studies on LifePharm nutritionals. She received her medical degree from the Almaty Institute of Advanced Medicine Education in Kazakhstan.
M.D., LifePharm Scientific Advisory Board Member
Dr. Natalia Tanuwijaya received her medical degree from Catholic University of AtmaJaya Jakarta, Indonesia. After graduating, she worked as a doctor in Atmajaya hospital and a few medical centers in West Jakarta. She took her career to the next level by taking additional courses and volunteering in Kings County Hospital in New York for 3 years. In September 2019, she joined Lifepharm as a Scientific Advisory Board member.
M.D, Scientific Advisory Board Member
Dr. Erna Wong has more than 29 years of experience working in pediatrics and the neonatal intensive care unit (NICU) at Kaiser Permanente in Orange County. The Irvine, California-based doctor retired in 2015 to devote her time to research, specifically focusing on alternative healthcare solutions. Dr. Wong received her medical degree from the University of Southern California Medical School in 1981, completed her residency in pediatrics at Kaiser Permanente in 1983, and received her board certification in pediatrics in 1984.
N.D, Scientific Advisory Board Member
Thomas Staudacher has worked in the field of holistic medicine since graduating from the Germany-based Paracelsus School of Naturopathy in 2003. The Australian-based naturopathic doctor founded a relaxation technique called Acoustic Restoration Therapy™ and currently runs both the International Holistic Clinic of Natural Medicine and Subtle Energy Solution. Staudacher received advanced diplomas in naturopathy, nutrition, acupuncture, and homeopathy from the Australian Institute of Applied Science in Brisbane.
PDR (Physicians Desk Reference), 2015-2018
7th International Conference on Predictive, Preventive and Personalized Medicine Molecular Diagnostics, Chicago, 10/2017
Orthopedic Muscular System Current Research 2017 6:3 (Suppl)
Dermatest Research Institute
University of Toronto
Wellness Medical Clinic
Thyroid Treatment Center
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent disease.

domain: biology


[Python-ideas] solving multi-core Python
abarnert at yahoo.com
Sun Jun 21 23:24:19 CEST 2015
On Jun 21, 2015, at 06:09, Nick Coghlan <ncoghlan at gmail.com> wrote:
> Avoiding object serialisation is indeed the main objective. With
> subinterpreters, we have a lot more options for that than we do with
> any form of IPC, including shared references to immutable objects, and
> the PEP 3118 buffer API.
It seems like you could provide a way to efficiently copy and share deeper objects than integers and buffers without sharing everything, assuming the user code knows, at the time those objects are created, that they will be copied or shared. Basically, you allocate the objects into a separate arena (along with allocating their refcounts on a separate page, as already mentioned). You can't add a reference to an outside object in an arena-allocated object, although you can copy that outside object into the arena. And then you just pass or clone (possibly by using CoW memory-mapping calls, only falling back to memcpy on platforms that can't do that) entire arenas instead of individual objects (so you don't need the fictitious memdeepcpy function that someone ridiculed earlier in this thread, but you get 90% of the benefits of having one).
This has the same basic advantages of forking, but it's doable efficiently on Windows, and doable less efficiently (but still better than spawn and pass) on even weird embedded platforms, and it forces code to be explicit about what gets shared and copied without forcing it to work through less-natural queue-like APIs.
Also, it seems like you could fake this entire arena API on top of pickle/copy for a first implementation, then just replace the underlying implementation separately.
More information about the Python-ideas


text:
Notoriously private Sports Illustrated model Jessica Gomes was seen for the first time with her new boyfriend former Wallabies star Rocky Elsom on New Year’s Eve.
The couple, who have kept their romance under wraps since reportedly getting together in June, could barely keep their hands off one another as they hit Sydney’s Palm Beach over the Christmas period.
Wading into the sea Jessica, 29, showed off her spectacular curves in a forest-green two-piece bikini, proving just why she has appeared in every swimsuit issue of Sports Illustrated since 2008.
The model who boasts perfect 33-24-36 credentials, looked in great spirits as she frolicked with her new beau, 31, her salt-sprayed brunette locks falling around her shoulders.
International face Jessica is based in the States but regularly returns to Australia to carry out her duties as David Jones ambassador, meanwhile Ricky is in Europe playing for the French team.
Reuniting for the Christmas period Jessica shared a slew of bikini pictures showing off her impeccable swimwear game, previously labeling the trip: ‘A Summer Holiday to remember forever!’
In June The Sunday Telegraph revealed that Jessica was off the market, after the model was heard discussing her new romance during a David Jones photoshoot.
She reportedly said: ‘I think we are official.
‘He’s a really great guy and I’m very happy.’
The aspiring actress and model has been single since splitting with her property developer boyfriend Sebastian Drapac the previous November.
Read more: http://www.dailymail.co.uk/tvshowbiz/article-2916064/Jessica-Gomes-seen-time-boyfriend-Rocky-Elsom-hold-hands-frolic-surf.html#ixzz3PLOn6XnE
Follow us: @MailOnline on Twitter | DailyMail on Facebook

domain: celebrity


text:
Being called a parent goes beyond birthing a child and for some people, they have had to raise other people’s kids and have made them their responsibility to provide them a better life. Some public figures have either adopted kids or gotten married to partners who had children in their lives before they came along and they decided to take on the responsibility seamless as a model humanitarian.
There are a number of men who are public figures in his this mode of a model father who chose to be stepfathers, adopted parent, and guardians to children that aren’t theirs biological, including celebrities.
Read also: 5 Other Ways To Identify If A Child Is Yours Without DNA Test
These amazing personalities have demystified the popular belief around raising other people’s kids, where it is believed that the children suffer when not raised by their own parents. Below are some of these public figures that are known to have taken up this responsibility;
1. Hope Uzodinma
Imo state governor Hope Uzodinma showed that he is a man with a good heart and a kind soul. In June 2020, he adopted a poor 9-year-old boy, whose video singing a Catholic hymn went viral on the internet. The governor was moved by the little boy’s angelic voice and chose to adopt him as a part of his family. Today the little boy’s life and that of his biological parents is changed forever.
Singer Flavour may have drama surrounding his brand and character but we cannot deny the fact that the actor has a great heart and a sweet personality. In the year 2017, he adopted a child with an impaired vision called Semah G Weifur who hails from Liberia. Semah was born visually impaired and was surviving with the help of Monrovia-based NGO, Christian Association of the Blind (CAB). The news of the adoption melted several hearts on social media as it showed the human side of the singer never seen before despite his numerous baby mama controversies. The adopted father and son released a single titled “Most High” which was a banging hit single. The two have been seen several times on social media serving goals and enjoying the most beautiful bond.
3. Williams Uchemba
Nollywood actor Williams Uchemba last year adopted an 18-year-old boy named Demola. The actor shared that he found the boy when he had gone shopping for furniture where he bumped into the teenager at the shop. After some conversations with him, Uchemba said he made up his mind to assist the smart young man. Today the boy’s life has been transformed and in recent snaps shared on social media, he seemed to be living the best life he could have ever imagined.
4. Daniel Aderinokun
Nollywood filmmaker Daniel Aderinokun is one man who has demonstrated that fatherhood is beyond birthing a child. The actor for several years was a father to the daughters of Stella Damasus who was his partner until last year. The actor had a great relationship with her kids and played the role of a father figure to them for years.
5. Ituah Ighodalo
The man of God is one of the public figures in Nigeria who demystified the idea behind fatherhood as many believed that you had to birth a child to be called father. The pastor adopted two beautiful children with his late wife Ibidunni Ighpdalo Keke and Zenan and openly shared their adoption story with the world. He is seen several times with the children and giving us all the amazing ideas of parenting.
KOKO Trending Video: Come, Forward, & Say The Truth – Odunlade Adekola Reacts To Claims He Demands For Sex From Actresses

domain: sociology