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The development of oncolytic viral therapy has recognized the importance of host cell and virus interactions in optimizing therapeutic efficacy. The mechanisms of poxvirus entry, the host factors that affect viral virulence, and the reasons for its natural tropism for tumor cells are incompletely understood. In particular, the mechanism of VV cell entry is opaque. It has been suggested that VV cell entry may occur by passive fusion with the cell membrane, or via uncharacterized receptors, or by macropinocytosis, followed by internalization requiring the coordination of complex actin dynamics (32
). VVs, including vaccine strains, have been shown to inherently target tumors (10
). This tumor selectivity is partially attributed to the activation of the epidermal growth factor/Ras-MEK-extracellular signal-regulated kinase (ERK) pathways and deregulation of interferon (IFN) pathways in cancer cells (36
). A greater understanding of the cellular factors essential for efficient VV infection would offer further insights into poxvirus biology and help to improve the development of VV as a novel anticancer therapeutic.
We have previously shown that the cytotoxicity of oncolytic VV is augmented by hypoxia in some PDAC cell lines (14
). In this study, we show that this is only in cell lines where there is hypoxic induction of VEGF-A. We used PDAC cell models with both VEGF-A overexpression and siRNA-mediated gene silencing to demonstrate that VEGF-A increases viral reporter gene expression, replication, and cytotoxicity. Quantitative PCR and direct fluorescent confocal microscopy of a fluorophore-labeled virus showed that VEGF-A increases the rate of virion internalization. The use of the clinically relevant inhibitor of the VEFGR (pazopanib) in cells stably expressing VEGF-A also demonstrated that VEGF-A can act in an autocrine manner to increase viral internalization, gene expression, and replication. We show here that VEGF-A can increase Akt phosphorylation, which is prevented by inhibition of the VEGFR, and that selective Akt inhibition reduces VV internalization. Using systemic administration of VVL15, a recombinant VV expressing fLuc, we were able to show that this finding is consistent in vivo
. We also demonstrated that this is replicated in NHBE cells, which are a natural host cell for VV.
Although other growth factors such as EGF and its receptor have recently been reported to augment the uptake of adeno-associated virus 6 (AAV6) and influenza virus A (38
), we have shown the role of VEGF-A in the VV life cycle. It is interesting that orf virus, from the genus Parapoxvirus
, produces a viral virulence factor, VEGF-E, which is the VEGF homologue most closely related to VEGF-A and contains all eight cysteine residues of the central cysteine knot motif characteristic of the VEGF family (40
). In addition, myxoma virus, a rabbit-specific poxvirus, has been shown to infect and kill human cancer cells only where there is endogenous Akt phosphorylation and activation (41
). Neuropilin-1, a coreceptor of VEGF, is a component of receptor complexes involved in the entry of human T-cell leukemia virus (42
This is the first study to our knowledge to demonstrate that VEGF-A signaling facilitates VV entry. In our study, silencing VEGF-A or inhibiting Akt activation did not prevent viral infection completely, supporting the concept that there are likely to be multiple pathways by which VV may enter cells, which may differ across cell types (43
). Integrin β1-mediated phosphatidylinositol 3-kinase (PI3K)/Akt activation has very recently been reported to be essential for vaccinia virus entry (44
). Integrin β1 is important for both vaccinia virus attachment and penetration. It has been reported that VEGFs and their receptors interact with integrins, including β1, on endothelial and tumor cells (45
). Further investigations are warranted to dissect whether VEGF interacts with integrin to affect the life cycle of VV and which VEGFR(s) is involved in such effects. However, our present study at least suggests that VEGF-A is one of the cellular factors that are responsible for the tumor tropism of VV.
In addition, an increase in vascularity induced by overexpression of VEGF-A may account for some of the effects in vivo
, although it does not give a conclusive indication as to the permeability of these vessels, which may also be important for VV spread (47
). Consequently, VEGF-A results in increased tropism of VV for malignant cells by increasing internalization and may also improve virus delivery in vivo
due to its role in tumor angiogenesis. The effect of the angiogenic state on tumor uptake of VV, cross traveling of VV from blood to tumor cells, and their relationship with VEGF expression are very interesting topics that warrant further investigations. Of note, our findings have implications for regimens that combine anti-VEGF/Akt agents with oncolytic VV for cancer treatment. It might be more reasonable to use anti-VEGF/Akt agents after treatment with oncolytic VV based on our findings in this study.
VV was widely used in the mass vaccination programs that eradicated smallpox in 1972. Although the immunity of vaccinated individuals lasts for decades (48
), a large proportion of the general population is still recognized to be extremely susceptible to variola virus and other poxviruses in the event of an intentional or unintentional release (49
). Therefore, it is important to look into more approaches to prevent and or interrupt poxvirus infection, especially in normal human cells. The identification of VEGF-A and Akt signaling as influences in VV infection in normal human epithelial cells () has important implications for treating poxvirus infection through targeting host cellular genes.

domain: literature


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NEW YORK (AP) — Actor Jonathan Majors was arrested Saturday in New York on charges of strangulation, assault and stalking, authorities said. On Sunday, Majors’ attorney said there was evidence that he was “absolutely innocent.”
New York police said Majors, star of the recently released films “Creed III” and “Ant-Man and the Wasp: Quantum Mania,” was involved in a domestic dispute with a 30-year-old woman. Police responded around 11 a.m. Saturday to a 911 call at an apartment in Manhattan’s Chelsea neighborhood.
“The victim reported to police that she was assaulted,” a NYPD spokesperson said in a statement. “The officers detained a 33-year-old man without incident. The victim received minor head and neck injuries and was taken to the district hospital in a stable condition.”
He was no longer in police custody Saturday night, a New York City police spokesman confirmed to The Associated Press.
A spokesman for Majors denied any wrongdoing by the actor.
“He did nothing wrong,” the spokesman said in an email to the AP on Saturday. “We look forward to clearing his name and figuring this out.”
On Sunday, Majors’ attorney, Priya Chaudhry, was more forceful, saying that Majors was “provably the victim of an altercation with a woman he knows” and blamed the incident on the woman who was having an “emotional crisis.”
Chaudhry said there was evidence to justify the major, including “video from the vehicle where the episode took place, witness statements from the driver and others who saw and heard the episode, and most importantly, two written statements from a woman who denies these accusations. »
An email seeking further comment from the NYPD based on Chaudhary’s allegations was not immediately returned Sunday.
Meanwhile, the U.S. Army has suspended a television ad campaign featuring the majors. The Army Enterprise Marketing Office said in a statement Sunday that the US Army is “deeply concerned about the allegations surrounding his arrest.”
“While Mr. Majors is innocent until proven guilty, prudence requires that we suspend our advertising until the investigation into these allegations is complete,” the office said in a statement.
Majors is one of Hollywood’s fastest rising stars. After his breakthrough in 2019’s The Last Black Man in San Francisco, Majors went on to star in Da 5 Bloods, The Harder They Fall and last year’s Devotion. He also starred in the recent Sundance film “Magazine Dreams,” which Searchlight Pictures plans to release in December.
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domain: law


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The hard money loan process is a little different than conventional loans. Since this is a private lender and not a bank, we are able to be more flexible with our loans. We are an asset based company, not credit based. This means that we don't look at your FICO or any required documents like a W-2 or tax returns. And we are able to close quickly. Sometimes we can close in as soon as 7 days if all conditions are met.
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domain: economics


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Zedd teamed up with Riot Games to deliver the new theme song for this year’s League of Legends World Championship. As host of the worldwide e-sports event, Riot Games sought to produce a music video celebrating the last 5 years of the tournament’s history in psychedelic-gamer fashion. The track is rife with Zedd’s signature beats and drops and features vocals from Tim James.
The League of Legends World Championship is one of the largest e-sports events held annually worldwide. The online multiplayer game is played both casually and professionally with the latter garnering viewership in the tens of millions. Last year, the finals were held at the Mercedes-Benz Arena in Berlin, Germany where 16 teams from around the world competed for a prize pool of over $2 million dollars. In the end, South Korea’s SK Telecom T1 team took home the first place prize of $1 million.
According to the League of Legends official YouTube page:
“Since its inception, Worlds has grown and evolved. Each unbelievable play and phenomenal match created moments and memories that will never be forgotten. In these iconic moments, players and teams reached for something incredible within themselves and brought it to life on the Summoner’s Rift.”
Zedd is set to appear at the 2016 League of Legends World Championships beginning September 29 at the Staples Center in Los Angeles. Taking place throughout October, the DJ/producer will be lending his own talents to the event, performing sets throughout the tournament. Additionally, you can stream the whole thing on Twitch, YouTube, and Azubu in multiple languages. Go to the official website for further information and be sure to check out “Ignite” — a collaboration between Zedd and Riot Games above.

domain: hobby


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IgA nephropathy is often detected after you notice blood in your urine or when a routine test shows you have protein or blood in your urine. These could be signs of several types of kidney disease. To identify your problem, these tests may be performed:
- Urine test. Blood or protein in the urine may be the first sign of IgA nephropathy. This may be discovered as part of a routine checkup. If your doctor suspects that you have problems with your kidneys, you may need to collect your urine for a 24-hour period for additional kidney function tests.
- Blood tests. If you have kidney disease, such as IgA nephropathy, a blood test may show increased blood levels of the waste product creatinine.
- Kidney biopsy. The only way for your doctor to confirm a diagnosis of IgA nephropathy is with a kidney biopsy. This procedure involves using a special biopsy needle to extract small pieces of kidney tissue for microscopic examination to determine if there are IgA deposits in the glomeruli.
- Iothalamate clearance test. Your doctor may also recommend an iothalamate clearance test, which uses a special contrast agent to track how well your kidneys are filtering wastes.
There's no cure for IgA nephropathy and no definitive way of knowing what course the disease will take. Some people experience complete remission and others live normal lives with low-grade blood or protein in their urine (hematuria or proteinuria).
Treatment with a number of medications can slow the progress of the disease and help you manage symptoms such as high blood pressure, protein in the urine (proteinuria), and swelling (edema) in your hands and feet.
Medications used to treat IgA nephropathy include:
- High blood pressure medications. A common complication of IgA nephropathy is high blood pressure. Taking angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs) can lower your blood pressure and reduce the amount of protein (albumin) in your urine.
- Omega-3 fatty acids. These beneficial fats, available in dietary fish oil supplements, may reduce inflammation in the glomeruli without harmful side effects. Get advice from your doctor before you start using supplements.
- Immunosuppressants. In some cases, corticosteroid medications, such as prednisone, and other potent drugs that suppress the immune response (immunosuppressants) may be used to help protect kidney function. But these drugs can cause a range of serious side effects, such as high blood pressure or high blood sugar, so their benefits must be carefully weighed against the risks.
- Statin therapy. Cholesterol-lowering medications may help to slow damage to your kidneys.
- Mycophenolate mofetil (CellCept). Most studies so far have failed to show a benefit for using this medication, but it has been used successfully in some people who have persistent protein in their urine despite treatment with medications that lower blood pressure.
The ultimate goal is to avoid the need for kidney dialysis or kidney transplantation. But in more advanced cases, dialysis or transplantation may be necessary.
Lifestyle and home remedies
To help keep your kidneys healthier:
- Take steps to reduce your blood pressure. Keeping your blood pressure levels near normal may help slow kidney damage from IgA nephropathy. Your doctor may recommend healthy changes in your diet — including limiting your salt intake — losing excess weight, being physically active, using alcohol in moderation and remembering to take your blood pressure medications as ways to keep your blood pressure under control.
- Monitor your blood pressure levels at home. Note each reading and bring this record with you to your doctor's appointments.
- Eat less protein. Reducing the amount of protein you eat and taking steps to decrease your cholesterol levels may help slow the progression of IgA nephropathy and protect your kidneys.
Coping and support
Coping with severe forms of IgA nephropathy can be challenging. But you don't have to do it alone. If you have questions or need guidance, talk with a member of your health care team.
You might also benefit from joining a support group, which can provide both empathetic listening and helpful information. To find out about support groups in your area that deal with kidney disease, ask your doctor. Or contact the National Kidney Foundation (NKF) to learn about PEERS Lending Support, a national, telephone-based peer support program from NKF. Call 855-653-7337 to participate.
Preparing for your appointment
If you have signs and symptoms of IgA nephropathy, you're likely to start by seeing your primary care doctor. However, you may be referred to a doctor who specializes in treating kidney disorders (nephrologist).
What you can do
To get ready for your appointment:
- Ask about any pre-appointment restrictions, such as fasting for a blood test, when you make the appointment.
- Make a list of any symptoms you're experiencing, including any that seem unrelated to the reason for your appointment.
- Make a list of all medications and doses, including over-the-counter drugs, vitamins, herbs or other supplements that you're taking — or take the original bottles to your appointment.
- Ask a family member or friend to go with you to help you remember all of the information provided during your appointment.
- Prepare questions to ask your doctor.
Questions you might want to ask your doctor include:
- What tests do I need?
- What is a kidney biopsy and how is it done?
- Is this condition temporary or long lasting?
- What are the chances that I'll develop kidney failure? Is there any way to know?
- What's the best course of action? How long will I have to take medications?
- What are the alternatives to the primary approach that you're suggesting?
- Can this disease be managed with diet and lifestyle changes alone?
- I have other health conditions. How can I best manage these conditions together?
- I've had urinary tract infections in the past. Could these previous infections be a factor?
- Do you have any printed materials on this condition? Is there a website you can recommend where I can learn more?
What to expect from your doctor
Your doctor is likely to ask you several questions, such as:
- When did you begin experiencing symptoms?
- Have your symptoms been continuous or occasional?
- How severe are your symptoms?
- Does anything seem to improve your symptoms?
- What, if anything, appears to worsen your symptoms?

domain: medical


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The High Museum of Art continues to WOW our guests with each new exhibit, Picasso to Warhol – 14 Modern Masters opens October 15, 2011 to April 29, 2012. Don’t miss your opportunity to enjoy over 100 Modern Masterpieces; this is the largest collection of modern art masterpieces ever exhibited in the the southeast. This exhibit is in collaboration with The Museum of Modern Art (MoMA), New York.
The Picasso to Warhol exhibit takes an in-depth look at each artists and their stylistic developments and highlights their role in the 20th century. They were the Modern Masters of the invention of Cubism, the development of Surrealism and brought us Abstract art. A few of my favorites are Henri Matisse Dance (I), 1909, Pableo Picasso, Girl Before a Mirror, 1932, Andy Warhol’s Self-Portrait, 1966 and Jackson Pollock’s, Number 1A, 1948.
Purchase your tickets on-line from The High Museum of Art before October 14, 2011 and be eligible to Win a Warhol Weekend Getaway to New York City. It includes round-trip airfare for two people, two nights accommodations, two tickets to the Museum of Modern Art, a private Warhol walking tour of the city and $200 for meals.
After a morning at the High Museum of Art head over to Table 1280 in the Woodruff Arts Center for lunch. Be sure and save room for desert, as the tiramisu is divine. Then take a leisurely stroll south on Peachtree Street back to our Atlanta Bed and Breakfast.

domain: artistic


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Foreign airlines risk restrictions on their permission to operate in mainland China if they fail to back the government’s stance on “one-China” as tensions between Beijing and Washington magnify national sentiment.
Over the weekend The Washington Post reported that the Civil Aviation Administration of China (CAAC) had sent a letter to 36 carriers last month ordering them to stop listing Taiwan, Hong Kong and Macau separately on their websites and mark them as part of China.
The CAAC’s letter to United Airlines dated April 25 gave it 30 days to respond and warned that non-compliance would be deemed “serious discreditable conduct” under the Measures for the Credit of the Civil Aviation Industry issued last November.
Other authorities such as the Cyberspace Administration of China will also enforce their respective laws, the letter added.
The regulations list “various punishments” that could be applied, including closer administrative scrutiny and demerits on their credit records.
Those deemed to have engaged in “serious discreditable conduct” might have their resources or administrative permits restricted or downgraded; or face problems when applying for new resources or administrative permits.
They could also be passed on to their own industry association for disciplinary action.
United Airlines, which still lists Taiwan separately on its websites, has passed the letter on to the White House for advice.
Many other international companies have also failed to comply with the order. For instance, Japan Airlines still offers area options under the heading “China/ Hong Kong/ Taiwan”.
On the other hand, Korean company Asiana Airlines has changed its website by offering destinations in Taiwan under the heading “mainland China, Hong Kong, Macau and Taiwan”.
Over the weekend, the White House condemned the demands as “Orwellian nonsense” and called on China to “stop threatening and coercing American carriers and citizens”.
Chinese foreign ministry spokesman Geng Shuang responded on Sunday that foreign enterprises operating in China must “respect the national sentiment of the Chinese people”.
The CAAC began to police how the foreign carriers refer to the Chinese-claimed territories – especially Taiwan, which it regards as a breakaway province – in January, when another American carrier Delta Air Lines was criticised by Chinese customers for listing Tibet and Taiwan as separate “countries”.
Delta apologised for “an inadvertent error” and said there was no political intention behind the listing. It has since removed Tibet from its website, but Taiwan is still listed separately from the mainland.
The nationalist furore unleashed followed a similar campaign that month against the Marriot hotel chain, which had also listed Tibet and Taiwan separately.
Since then Chinese internet users have started to watch multinational firms’ activities in China closely and pressured the authorities to act against those branded transgressors.
Analysts have suggested that the current spat follows the recent trend of Donald Trump’s administration playing up the Taiwan issue.
Yuan Zheng, from the Chinese Academy of Social Sciences, said the government in Beijing needed to respond to nationalistic public opinion and give a robust response as cross-strait relations deteriorate.
The White House’s intervention in the current row was highly unusual because such matters are usually left to the State Department, said Wu Xinbo, director of the Centre for American Studies at Fudan University.
“It is very likely that this was advocated by John Bolton,” said Wu.
Bolton was recently named as Trump’s new National Security Adviser and his appointment, coupled with his long-standing support for Taiwan, brings fresh challenges to Beijing’s increasingly aggressive stance towards the self-ruled island.
“While Trump doesn’t have a clear understanding of the Taiwan issue and only uses Taiwan as leverage, people like Bolton sympathise with Taiwan,” he added. “The Chinese side is very alarmed by it and is likely to react strongly.”

domain: politics


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Where to get seasoned food
Are you interested in some black culture just in time for Black History Month? Check out these businesses throughout Baltimore and Columbia. It is incredibly important to help support all businesses, big or small, within the black community.
Busboys and Poets is found in Columbia near Merriweather Post Pavilion. It thrives because of its culture, entertainment, and environment. This restaurant is named after Langston Hughes, an African American poet who was a busboy before he was recognized for his poetry. The restaurant offers vegetarian, vegan, and gluten-free options and is open for brunch and dinner. This is a great place to have a tasty meal and experience the new developments in Columbia!
Address: 6251 Mango Tree Rd, Columbia, MD 21044
Althea’s Almost Famous is a food truck known for traveling to our Oakland Mills Village Center. It also visits the Oakland Mills Farmers Market. Reviewers rave about their food with its spicy kick and delicious taste. Even though they don’t have a restaurant for you to dine in, they do have a home base where you can get curbside pick-up.
Address: 5881 Robert Oliver Pl, Columbia, MD 21045
Po Boy Jim Bar and Grill in Columbia serves a variety of meat dishes with great service. Jim isn’t the owner of the bar and grill, Jim actually stands for Jeff, Ian, and Mothers. Po Boy Jim Bar and Grill focuses on spices and fresh herbs, which is said to be a family tradition passed down. Even though the food is not as spicy as Althea’s, they consistently provide delicious dishes. Their location is in close proximity to the mall, so if you are in the area, you should stop by and grab a sandwich!
Address: 10000 Town Center Ave Suite B, Columbia, MD 21044
Chick N’ Friends is old, but lovely. Located near Giant in the Owen Brown Village Center, Chick N’ Friends has been part of the community for years. This family restaurant passed down from generation to generation is an oldie but a goodie. Kemberly Lloyd, the current owner of Chick N’ Friends, is making sure the restaurant blooms. From chicken to fish, there is a traditional dish for everyone to enjoy. Their fries are fantastic with excellent seasoning that compliments their main dishes well.
Address: 7290 Cradlerock Way, Columbia, MD 21045
Anegada Delights Caribbean Cuisine is a little hidden food place near Lake Elkhorn with great food and generous portions. Nestled in a business complex, their tangy food sets them apart from other restaurants. With its trademark vegan and vegetarian options, it is a great place to enjoy some Caribbean cuisine!
Address: 9861 Broken Land Pkwy St 151, Columbia, MD 21046
Milk & Honey Cafe is classy, clean, and modern. They provide both breakfast and lunch. Though it’s a little far, I’ve heard that the food is delicious and they have a variety of delicious fish and meat. That helps support their New Orleans themed restaurant.
Address: 10280 Baltimore Ave, College Park, MD 20740
Miss Carter’s Kitchen in Baltimore City has baked and fried chicken as their specialty. Their nostalgic “cookout” dishes and Cajun roots make their spice combinations unmatched. Chief and owner Cia Carter, started her business in her own kitchen, when she started to expand she made sure to keep her cooking style.
Address: 103 W Lexington St, Baltimore, MD 21201
More than Java Cafe is a small restaurant in Laurel that sells personalized juice along with numerous breakfast options. They are one of my personal favorites since they are inclusive to many dietary restrictions. They have a vegan breakfast sandwich that’s rich in flavor.
Address: 358 Main St, Laurel, MD 20707
All of these black-owned businesses are great places to have a delicious meal. So, during Black History Month, consider supporting these black-owned businesses!

domain: food


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Lime and Lime Mortars
Elsewhere $66 $42.86 Save $23.14 (35%)
Free shipping Australia wide
Order Now for Christmas with e-Gift
|Format: ||Paperback, 96 pages|
|Other Information: ||glossary, bibliography, index|
|Published In: ||United Kingdom, 05 January 1998|
Hurry - Only 2 left in stock!
First published in 1927 by the Building Research Station, this volume provides a classification of lime and a complete review of its various uses in building construction and repair. This facsimile edition should be of interest and of practical value since the methods, terminology and practices detailed by Cowper are still valid today. A brief historical introduction to the subject is followed by a section on the process of lime burning which emphasizes the differences in behaviour of the various classes of limes. The results of research and tests to determine the most reliable and lasting limewashes and lime-based cold water paints are also detailed. In addition, the book provides useful information on the common problems occurring with lime plasters and how these can be solved. The classifications based and suggested applications in the book offer guidelines for the conservation practitioner.
Table of Contents
Historical The Process of Lime Burning Classification The Uses of Lime in Building Limewashes Lime Plaster Pozzolanas Mortars and Cncrete Specifications
- warmly recommended as it is as relevant today as it was 60 years ago. Journal of Architectural Conservation Interesting, informative, knowledgeable - If you are in or into conservation it looks like essential reading. Masonry International This new facsimile edition will be of substantial interest and practical value since the methods, terminology and practices detailed by Cowper are still valid today... The suggested specifications in this book offer helpful guidance for the conservation practitioner. Listed Heritage
24.4 x 17.2 centimetres (0.29 kg)|
15+ years |

domain: library


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Luxury cruising is riding the crest of a wave, writes Andrew Conway, and there’s never been a better time – or way – to explore the world
At any given time, on any given day, a luxury cruise ship is slipping its moorings and heading towards the open ocean, along a slow-moving river, or exploring the wildest and most remote destinations on the planet.
It could be Crystal Serenity sailing gracefully out of Monte Carlo on a chic Mediterranean sojourn; Viking Heimdal cruising languidly under the historic bridges of Budapest; Silver Explorer standing by off the coast of Vancouver as a pod of orca whales splashes in front of its bow, or MS Europa 2 on its inaugural voyage to Japan.
So many ships, ports, destinations, unforgettable experiences and choices. Luxury cruising is now the fastest-growing sector of the global travel market, a multi-billion-dollar industry that knows no bounds.
The steamer trunks may have disappeared, along with the hat boxes, white tails and smoking jackets, but a new golden age of luxury cruising – with a thoroughly modern twist – has dawned.
More Australians are cruising than ever before and more ships are rolling off international production lines, each bigger, smaller and better than the last one.
Humble cabins have been transformed into spacious and luxurious staterooms, suites and penthouses, all with private balconies to watch the waves pass by. Single-seating dining and dreaded midnight buffets have been brushed aside, replaced by an array of chic celebrity-chef restaurants delivering the world on a plate.
And forget keeping fit and healthy on the promenade deck. Today’s luxury liners boast extraordinary wellness retreats and spas operated by the finest on-land brands.
Silver service comes in the form of neatly pressed butlers, while curated and exclusive shore excursions open doors to a private world of luxury in palaces, castles, vintage wineries, art galleries and museums.
Luxury ocean and river cruises are expanding like never before, with an armada of liners and longships offering a seemingly endless choice of new destinations and itineraries.
But perhaps the most exciting change is in luxury expedition cruising, with brand new, purpose-built and ecologically sound small ships taking fortunate and well-heeled passengers to the world’s final frontiers from the North Pole to the Antarctic, and all points in between.
The age of luxury cruise passengers is dropping like an anchor, down from the mid-70s of yesteryear to the late 40s of today. And more major cruise lines are basing their flagships in Australian waters than ever before.
Barely a day goes by during Sydney’s busy summer cruise season when a liner of varying size and style isn’t berthed at the Overseas Passenger Terminal or White Bay Cruise Terminal.
Cruise industry hype? Think again. The latest annual Source Market Report by Cruise Lines Industry Association (CLIA) Australasia reveals Australian cruise passenger numbers hit another record high last year with 1.34 million passengers taking a cruise.
The local cruise market grew by 4.4 per cent, equating to
almost six percent of the population in 2017, putting Australia on par with the US as the world’s fastest-growing cruise market.
Accounting for 5.4 per cent of the 27.6 million people worldwide who took a cruise in 2017, Australasia is now the world’s fourth largest cruise region.
And CLIA Australasia Managing Director Joel Katz says there is still so much more potential. “As cruising continues to grow in popularity, more cruise lines will base more ships down under and the number of homeports and itineraries will only grow,” he says.
“With the equivalent of almost one in every 18 Australians cruising last year, Australians are overwhelmingly choosing a cruise as their holiday of choice and they’re coming back time and time again.”
The majority of Australians are cruising in local waters, New Zealand and the South Pacific, while the average age of Australian passengers is now just 49 years old.
CLIA’s most astonishing revelation is this: 109 new cruise ships, the majority of them luxury, are scheduled to be delivered globally between now and 2027 at a total cost of more than US$58 billion.
So, what’s the essence of this new wave in high-end travel? “Today’s luxury cruise passenger is seeking freedom and choice,” says Amanda McCelland, CEO of Cruiseco, the largest distributor of luxury cruise product in the southern hemisphere.
“They expect cutting-edge design, amazing personalised service, ‘wow’ experiences, and the freedom to do what they want, when they want, and how they want.
“My idea of luxury cruising is being with like-minded people who share similar interests, along with a curated experience and great value,” she adds. “Luxury cruising must cater to the individual’s needs, wants and desires, such as dining in the comfort of your suite or stateroom or in one of the ship’s five-star restaurants.”
Luxury cruise lines – especially those with small expeditionary ships – are becoming ever more creative with ideas to enhance their passengers’ personal experiences. “We work to overlay the expected with the unexpected,” says Monique Ponfoort, Ponant’s Vice President Asia Pacific.
“The ship’s captain inviting you to the bridge for a personal overview; an expedition team member taking time to chat to you about her time in Borneo working with orphan orangutans; a Zodiac driver moving closer to a saltwater crocodile so you can get that special photograph; or the surprise champagne bar popping up in the middle of nowhere,” she adds.
“Ponant overlays this level of detail when exploring some of the most remote places on Earth, meeting with Inuits in the Arctic, small tribes in New Guinea or in the Amazon Basin. These are rare moments that add extraordinary layers to the word ‘luxury’.”
“Luxury cruising today is about choice – and quality of choice – for people who want to travel in elegance and luxury all over the world,” says Karen Christensen, who helms the five-star, all-inclusive Crystal Cruises in Australia and New Zealand.
“The special moments Crystal provides are so strong and impactful that people don’t feel the need to go anywhere else. From the second our guests step on board a Crystal ship, the warm, attentive service, the contemporary and spacious design, acclaimed Michelin-inspired dining, and carefully curated shoreside experiences are all effortlessly delivered.”
Christensen says the company has seamlessly integrated its signature ‘Crystal Experience’ across all four of its luxury brands – ocean, river, expedition, and exclusive private jet Crystal Sky.
“This attention to detail has remained true to Crystal’s original cornerstones of service, space, quality and choices, and to me, the essence of luxury cruising goes far beyond the ships themselves to the itineraries and shoreside experiences, immersing guests in new cultures and destinations around the globe,” says Christensen.
“We have a comprehensive collection of destination experiences focused on authenticity,” she adds, “many tailored to guests’ individual interests and passions, from food and wine to culture, art and music. Crystal recognises that today’s luxury traveller desires that personal touch, from the ship to the shore.”
While major cruise lines are spending billions of dollars on new and refurbished ships and services to stay relevant to the incessant needs and demands of contemporary travellers, they also have to keep pace with the ever-changing concept of ‘luxury’ in today’s crowded and highly segmented tourism market.
A very high level of accommodation, food, wine and service, along with quality linen, toiletries, room service, and well-organised shore tours are now a given at the top end of the luxury cruising market.
A handful of the most luxurious lines offer all-suite and all-inclusive cruises to stay one step ahead of the competition. Regent Seven Seas Cruises, for example, includes free and unlimited shore excursions on all of its ships – Seven Seas Explorer, Mariner, Voyager and Navigator – with optional bespoke tours if guests want to pay to elevate their onshore experiences.
And the new Seven Seas Splendor, scheduled to launch in 2020, will raise the bar even higher. “Splendor will be a game changer and set a new standard in luxury cruising,” says Steve Odell, Managing Director Asia Pacific of Norwegian Cruise Line Holdings (NCHL), which owns Regent, the premium Oceania Cruises, and the leviathan Norwegian Cruise Line.
Odell says NCHL has spent US$125 million on refurbishments to Seven Seas Mariner, Voyager and Navigator in the past 18 months – good news for Australian cruise enthusiasts as Mariner will be here in December and Navigator will follow in her wake next February.
Even mass market mega-liners are cruising into the luxury segment with Norwegian Cruise Line incorporating an exclusive concept called The Haven into its seven mega-liners.
“It’s a suite-only concierge space with a private restaurant and bar, guests are fast-tracked everywhere, get priority dining reservations, and can use all the facilities of the ship or relax in The Haven,” says Odell, a 30-year veteran of the global cruise industry.
“It’s a very appealing concept to the extended and multi-generational family market where grandparents and parents can enjoy the luxury and privacy of The Haven while the kids go off and enjoy all the ship has to offer.”
The luxury cruising industry’s approach to younger, extended and multi-generational guests is catering to new and emerging demographics.
Yuppies and Dinks of previous generations are now Henrys – High Earners, Not Rich Yet – and Skip-Gens, a rapidly growing multitude of well-heeled grandparents who are taking their grandchildren travelling instead of their own children.
Henrys are individuals in successful jobs, have significant discretionary income and a strong chance of being wealthy in the future, and are very familiar with the leading luxury brands.
While Henrys might think cruising is for an older generation, they are dipping their manicured toes into luxury river cruising with companies like Uniworld Boutique River Cruise Collection.
This award-winning line has 18 sleek river cruisers in Europe and worldwide – all delivering on the credo: “No request too large, no detail too small” – and offers U by Uniworld, a new take on experiential luxury cruising specifically tailored to a younger but high-income market.
Expedition cruising is undergoing one of the biggest and most exciting transformations. Once the remote domain of sturdy and non-stabilised Russian ice-breakers – with basic cabins, simple food and burly crew – today’s version can be five-star luxury all the way.
Leading the charge to explore the planet’s final frontiers – from the North Pole to Antarctica – is French luxury expedition cruise line Ponant which currently has its original masted ship Le Ponant, four sister ships built between 2010 and 2015, and a flotilla of luxury Explorer vessels recently launched or on order in the next three years.
The brand new Le Laperouse is currently cruising Iceland and will sail to Australia in 2019. A sibling will also launch this year with two more in 2019, another two in 2020, and a luxury icebreaker setting sail in 2021.
Sarina Bratton AM, Ponant’s Chairman Asia Pacific and a pioneer of the luxury cruising industry here, says the new Explorer ships will have only 90 staterooms and suites with private balconies. “They have a real feel of being on a private super-yacht,” she says.
“And our new eco-friendly luxury icebreaker will be state-of-the-art hybrid electric, powered by LNG, able to cut through two metres of ice, and take guests in luxury to the North Pole. And it’s just the beginning, a glimpse of what the next generation of expedition cruising will look like.”
“Luxury means different things to different people,” says Leanne Fonagy, Director of Marketing Asia-Pacific for Silversea Cruises, “and the nature of luxury is changing, replacing ostentation and opulence with authentic, sophisticated and memorable experiences.
“For Silversea, the true essence of the experience we offer is one of intimate and whispered luxury. Our guests are very well travelled and searching for new destinations and enriching life experiences. They appreciate luxury, comfort and value, but they are actively seeking a deeper travel experience – up close, immersive and authentic.”
Managing director of award-winning cruise specialist Wiltrans International Diane Patrick, who has represented some of the world’s best-known luxury cruise brands for three decades, insists the market has never been more exciting.
“This is a wonderful time to be in cruising and to be cruising,” she says. “The evolution of the ships, onboard products and services has been so dynamic through the years, and I only see it getting better.”

domain: geography


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Loved the look of this bag when I ordered it. The sides are structured, and the middle holds its shape when sitting, but when carrying, the middle slouches around the top and midsection (not the bottom so much). Because the middle is of a softer leather, it drapes and can show bumps/corners of the bag contents. This bugged me, so I tried a bag organizer insert that I had on hand, and that improved things. Also, zipping the bag closed will help maintain the structure. I wish the zipper was a little smoother to operate, and the soft leather was a little more structured, but otherwise I like the bag.
Sizing: True to Size / As Expected
report inappropriate content

domain: design


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TORONTO — Whistleblowers saved lives during the first wave of COVID-19 in Ontario’s long-term care homes, the patient ombudsman said in a report Thursday. And they need legal protection so they can keep speaking up.
“Many of the whistleblowers Patient Ombudsman spoke with were very fearful of retaliation and the impact speaking to our office would have on their jobs,” the new report said.
“There has been discussion of legislation to protect businesses and employers from liability resulting from the pandemic. Healthcare workers who are at risk of infection and choose to raise alarms when patients and residents in their care are at risk are no less deserving of protection.”
Patient ombudsman Cathy Fooks investigates complaints about Ontario’s health-care system. Her office put out a call for complaints about COVID-19 in April after receiving several “very concerning reports” and announced its investigation into long-term care in June.
The office received 20 complaints from staff in long-term care homes and many more from “unidentified staff members raising serious concerns.”
These workers reported:
- COVID-19-positive staff were being forced to work;
- Residents’ lives were in danger because they weren’t being fed properly or given their medicine due to staffing shortages;
- COVID-19-positive residents were not being isolated from others;
- Staff were not given personal protective equipment (PPE) and not allowed to bring their own because it would “alarm” residents;
- Errors in documenting COVID-19 cases meant that staff were unknowingly caring for patients who had the virus without PPE.
“Patient Ombudsman commends the courage of those health care workers that spoke out about what they saw, heard and experienced in Ontario’s long-term care homes. The information these individuals provided brought needed attention to the appalling circumstances in a number of Ontario’s longterm care homes and likely spurred the government to take significant action, including calling in the Canadian Armed Forces,” the report said.
The investigation is still ongoing but Thursday’s report made preliminary recommendations to Premier Doug Ford’s government.
Minister of Long-Term Care Merrilee Fullerton said that whistleblowers do have some protection under the Long-Term Care Homes Act but that the ombudsman wants something stronger.
“We take those recommendations to heart,” she told reporters at Queen’s Park.
“We need to make sure that people can come forward with concerns about shortcomings or issues … The more these things are hidden, the harder it is to find them and address them.”
NDP Leader Andrea Horwath said the report shows that Ford’s “penny-pinching” is causing problems.
“The report from the Patient Ombudsman paints a harrowing and devastating picture of the chaos in our long-term care homes during the first wave of COVID-19,” the Opposition leader said in a statement. “Because Doug Ford didn’t want to invest in safety measures, homes were chronically understaffed without the infection controls and personal protective equipment they needed to control outbreaks.”
Ford’s government has also launched a commission to look into the spread of COVID-19 in Ontario’s long-term care homes.
The commission recently heard from the head of an association that represents hundreds of homes. She said funding cuts made by Ford’s government in 2019 were “profoundly destabilizing.”
“We say that we were facing a perfect storm as we got into COVID-19,” Donna Duncan, CEO of the Ontario Long Term Care Association, said.
The association first rang the alarm about COVID-19 in January, Duncan said. Ford’s government published its action plan for the sector on April 15.
Long-term care residents have accounted for 65.3 per cent of Ontario’s 2,992 COVID-19-related deaths. Eight staff members have also died.
There are currently 57 outbreaks in homes.
What You Need To Know About Thanksgiving, According To An Infectious Diseases Expert
More Than 220 Canadian Troops Caught COVID-19, Military Reveals
Ford Vows To Exhaust Options Before 'Ruining' Lives With 2nd Shutdown
Click Here: camiseta rosario central

domain: sociology


Don't miss your last chance to party.
Enter a world of creativity and freedom... Boomtown fuses boundary pushing theatre and arts with a global, genre spanning musical bill!
Read on for the full AREA 404 line-up, our latest of 12 individual district releases and immerse yourself in one of the soundtracks to the city...
Following on from our announcement of the brand new district in Decemeber - with Carl Cox, Four Tet, and Amelie Lens headlining the area’s main stage Nucleus, we've now added the full line ups for the three other new stages for this area: The Grid, Fallout Disco and Acid Leak. Covering bass heavy sounds, house & disco plus hard house and acid techno respectively this is an area with all electronic tastes catered for and an exciting addition to the multi genre, multi layered festival, again ensuring that Boomtown Fair stands out from the crowd as one of the best festivals in the UK.
Introduction of the new bass and jungle focused arena, The Grid, will kick things off with underground Bristol label Gutterfunk curate a diverse day takeover featuring Dub Phizix & Strategy, Addison Groove, Dismantle, Madam X and a 1995-2019 ‘archives’ set from label head honcho DJ Die. The massively influential underground Rinse FM are celebrating 25 years of the station with a showcase of the best in bass and grime UK sounds. Bringing together two heavyweights of the bass scene; Redlight and Zinc go back to back for a special set. Other fresh homegrown talent such as Bushbaby ,Conducta and Rinse FM selector Emerald join godfather of garage Matt Jam Lamont, dancehall luminaries The Heatwave and South London’s Manara with her unique blend of global club cuts, house, grime and Bollywood samples. Sunday welcomes back Boomtown favourites and jungle legends Congo Natty ft Nanci & Phoebe, some of the biggest names in jungle from across the atlantic, Liondub b2b Marcus Visionary, moody drum and bass from Bou and an exciting showcase from the Legends of Moving Shadow featuring 2 Bad Mice B2B DJ Trax, Foul Play B2B Cloud 9 B2B Nookie, Kaotic Chemistry B2B Deep Blue hosted by Mc Flux.
The introduction of two brand new post-apocalyptic ‘street venues’ include the ‘Fallout Disco’ hosted by Bristol collective Shambarber with a line-up spanning house, disco and electronic, includings; Lord Leopard, party providers Alfresco Disco, Bitch, Please and more.
On the other side of the electronic spectrum the Acid Leak will see the full on return of Old school acid techno to the streets of Boomtown with genre pioneer Chris Liberator, DJ Kaynasty and Jah Scoop on the bill alongside some of the scenes lifelong ambassadors.
The brand new area will open its streets on Thursday with a very fitting and welcome return of underground pioneers SP:23 (Spiral Tribe) Street Party bring with them the 90’s convoy takeover featuring crystal distortion, 69db, jeff23, bad girlz, ixindamix, meltdown mickey, max volume.


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Decent game, obviously needs work. Great game, but the following things MUST be added for the game to be complete: Random matchups, start games with random people, not just friends. Better animations, animations that are based on the unit, not just arrows and random tiny guys. And of course, more cards! Maybe a campaign to unlock them? Finally, a save feature! You can save custom decks, but not the game we are currently playing? Fix all this and five stars are yours. I also have the pro version.
How about an update?
This game is awesome
Don't think this is supposed to happen But every time I play vs Ai it pops up a card and stays on any difficulty I use Samsung galaxy s4
Cant play right I start a nw game and I play a card aftr that Its the CUP turn th card pop up ect. Attack and the card just stay like that and ip cant do everything but exiting game
Awesome! Best castle defence game i have played EVER!!!!!
- Fixed game stopping when AI played card
- Fixed Google Play Services bug
- Small changes

domain: game


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The railway station of Santa Maria Novella, Florence
Largo Fratelli Alinari, 1, 50123 Florence, Italy
The railway station of Santa Maria Novella - is the main railway station of Florence and one of the most important stations in Italy , serving about 60 million passengers a year.. On regional trains departing from the station , you can get to Rome , Venice, Naples and other cities in Italy. Near the railway station is the main bus station, which, in particular , are buses to the airport of Florence. The railway station of Santa Maria Novella is close to many historical and cultural attractions. It is a ten minute walk from Florence Cathedral and in fifteen minutes - from the Piazza della Signoria and the Uffizi Gallery - one of the oldest and most famous art museums in the world.

domain: history


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(10.21) The Arcade has been hopping lately with new energy and new stores. Add to that the Fall Urban Vintage Bazaar and it’s a scene. (Facebook event page.)
Over 25 vendors of quality vintage goods in one place for one day! Men’s and women’s vintage clothing and accessories, vinyl records, vintage cameras, lighting & housewares, linens, ephemera, holiday items, art, antiques, pop cultural artifacts, vintage toys and games, Halloween costume ideas and so much more.
This event features a “Vinyl Lounge;“ an entire room devoted to selling nothing but vinyl records and other music‐related items. Confirmed vendors for the Urban Vintage Bazaar include Mirrorball Boutique Vintage, Archetype Vintage, Mim’s, The Embassy Antiques, Vintage Ginger’s Closet, White Buffalo, Uptown Vinyl, Guess What I Have?, Mayflower Vintage, The House of AMA, Pinkham Road, The Bird’s Nest, Carefully Curated, Infectious Fun Toys, Red Rabbit 860, Gina’s Creations and Vintage, Hot Glue Heroes, Shoppe Pioneer Vintage and of course, the Arcade Providence’s vintage retailers, Bad Taste, Split Apart Secondhand, Cured Collection and the event organizer, Carmen & Ginger.
Perfect time for Halloween shopping at Carmen & Ginger with its assortment of decorations, and vintage clothing and jewelry for dress-up and real life. Relax with a beverage at New Harvest Roasters Coffee & Spirits. The weather is going to be ideal.
10am to 5pm, Saturday, October 21, Arcade Providence, 65 Weybosset Street, (directions)


Gadkari, Minister for Road Transport, Highways and Shipping, called on Wickremesinghe here today and discussed construction of a sea bridge and an underwater tunnel linking 22-km stretch between Talaimannar in the island nation and Dhanushkodi in India, official sources said.
To improve connectivity with the neighbouring nations, India has signed motor vehicle pacts with Bangladesh, Bhutan and Nepal and is also proposing to improve connectivity with Sri Lanka.
"Multi-lateral funding agency ADB, which has already agreed to finance infrastructure projects worth about USD 8 billion for Bangladesh, Bhutan, India and Nepal (BBIN) region, has also shown keen interest in financing USD 5.19 billion India-Sri Lanka proposed project," a source said.
Sources said it was also proposed during the meeting that a Secretary-level meeting along with the representatives of ADB can be held in Sri Lanka to discuss the project.
India also wants Sri Lanka to join the BBIN Motor Vehicle Agreement, signed in June this year in Bhutan during Gadkari's visit there, which aims to facilitate cross-border movement of all types of vehicles in the BBIN region.
India also wants Sri Lanka to join the BBIN Motor Vehicle Agreement, signed in June this year in Bhutan during Gadkari's visit there, which aims to facilitate cross-border movement of all types of vehicles in the BBIN region
Work on the USD 8 billion road connectivity projects among Bangladesh, Bhutan, India and Nepal (BBIN) is likely to be completed within two years.
India would also enter into another landmark motor pact with Myanmar and Thailand by year-end.
Gadkari had earlier said ADB is ready to finance the project "for providing connectivity to Sri Lanka".
He had said there was a missing link of narrow corridor of about 22 km in connectivity to Sri Lanka from Rameshwaram which is presently being serviced through makeshift ferry service arrangements.
"We are working on the project and as soon as it is completed, Trans Asia Road and transport network could be extended to Sri Lanka," Gadkari had said.
"ICVs are seeing a spurt in demand and this is the best time to introduce our proven I-Gen6 BS-VI technology in one of our best-selling brands in the portfolio. These launches will further strengthen our portfolio and help us achieve our vision of being in the global top 10 CV makers," Vipin Sondhi said.


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After impressing the audience with his performance in Abhishek Kapoor's Kedarnath last year, Bollywood star Sushant Singh Rajput is all set to rule 2019 with his upcoming projects. The actor will be next seen in Abhishek Chaubey's dacoit drama, Sonchiriya which stars Bhumi Pednekar as the female lead. Interestingly, Sushant's upcoming release will have a box office clash with his rumoured girlfriend Kriti Sanon's Luka Chuppi as both the films will hit the screens on March 1.
Recently, in an interaction with ZoomTV.com, Sushant expressed his views over both the movies releasing on the same date and said, "Clash? There is no clash. It's not like in one theatre we'll have both the films playing on two walls."
While Sonchiriya narrates the journey of the rebels and dacoits of Chambal, who fought with the police force in the 1970s, Luka Chuppi is a rom-com featuring Kartik Aaryan as the male lead. The movie revolves around Kartik and Kriti's character and their complicated live-in relationship.
Meanwhile, rumours of Sushant and Kriti dating each other have been rife ever since they shared the screen space in Dinesh Vijan's Raabta (2017). The duo has neither refuted nor confirmed the rumours going around the tinsel town.
During his conversation with ZoomTV.com, Sushant also talked about his film Sonchiriya and how he prepared for it. Check out the video below.
Apart from this, Sushant will also be starring in the Hindi adaptation of The Fault In Our Stars. The movie has been titled Dil Bechara and is being directed by Mukesh Chhabra.
Stay tuned to this space for more updates!


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Slowly but surely, I’m still making stickers for my Redbubble account and I am having a blast while doing so. People from all over the world have been buying my stickers, like the United Kingdom and Puerto Rico for example, and it is such an awesome feeling knowing that people really like my work and want to showcase it. I even ordered a couple of my own stickers to see what they look like in person!
The first thing I always think of when designing my stickers is whether or not I’d want to own them and put them somewhere, so I like to make sure that the answer is always in fact, yes. That’s really important to me; that I really love my own work and take pride in it that I would want other people to see it and know it is mine. That’s why I like to use a lot of watercolor and beach themed items in my work, I’m exploring and starting to develop my own personal style that one day others will be able to recognize.
Recently, I incorporated some more watercolor work into my design of two field hockey sticks. I play for the field hockey team at Marywood and I’ve enjoyed playing the sport for a good amount of my life, so I thought why not make a cool sticker about something I love. I’ve been pleasantly surprised with how popular it has been, and I think it helps that it’s unlike any of the other field hockey stickers on the site. I also took note of some of the other Redbubble artists’ work and noticed that a lot of them create a bunch of little individual stickers that all go together as a cohesive set. I decided to play around with that idea and make a set of wave stickers. I played around with a bunch of color palettes and really liked what I ended up with. Making stickers has been a really fun pastime for me lately, and I can’t wait to see where it takes me and what other stickers I’ll have made by the end of the summer.


Alfred Watzl has retired from machinery and equipment supplier Fleissner where he was responsible for marketing and sales activities for the Egelbach, Germany-based company. During his nearly four decades with Fleissner, Mr. Watzl exerted a decisive influence on the development of nonwovens installations. Under his responsibility as a sales and marketing expert, a variety of machines including Fleissner AquaJet, components for airlaid web lines and heavy duty production lines for man-made fibers were developed, built and sold worldwide. He contributed to the continuous improvement of equipment in constant response to the demands of the market.
Rüdiger Weinhardt has taken over responsibility for all marketing and sales activities as director of sales, effective January 1, 2008.


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Texas Medicaid uses an All Patient Refined – Diagnosis Related Groups (APR-DRG) payment system for inpatient hospital providers that are reimbursed based on a DRG payment methodology. The APR-DRG methodology focuses on all Medicaid client populations and addresses patient severity of illness and patient risk of mortality in addition to patient resource intensity.
Hospital reimbursement is described in detail in the Inpatient and Outpatient Hospital Services Handbook in the Texas Medicaid Provider Procedures Manual (Vol. 2, Provider Handbooks).
For more information, visit the Hospital Services web page on HHSC website.
The following files include the diagnosis-related group (DRG) Grouper files and the Standard Dollar Amount (SDA) Add-ons for individual hospitals.

domain: health


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The Sundance Film Festival wrapped up yesterday in Park City, Utah, and our pick for a breakout is Tony Donoghue‘s Irish Folk Furniture. The charming animated documentary (watch it below) follows the fate of 16 pieces of traditional folk furniture as they are repaired and return home. “In Ireland, old hand-painted furniture is often associated with hard times, with poverty, and with a time many would rather forget,” notes Donoghue, who worked for seven years at the Trust for Urban Ecology and the Natural History Museum in London before turning his full attention to filmmaking. When Irish Folk Furniture won the jury award for animation at the Sundance short film awards ceremony, he arrived at the podium carrying a pint. “The fact that I’m Irish and have this beer is completely coincidental,” Donoghue assured the audience.
Create and manage a top-notch freelancing career in our upcoming online event. Through a series of webcasts and workshops, attendees will be able to learn the tools necessary to launch a successful freelancing career. Weekly sessions will cover topics including pitches, query letters, portfolios, and financing. With St. Patty’s Day quickly approaching, we invite you to try your luck with code GETLUCKY and win anywhere from $10-$50 OFF registration! Register Today!


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Is Africa truly free of wild polio?
n August 2020, the World Health Organization (WHO) certified the African region as wild polio-free after four years without a case on the continent. The announcement came after Nigeria, which has long battled challenges such as vaccine hesistance, political instability, ethnic violence and rough terrain with regard to eradication of the disease, became the last African country to be declared wild polio-free. Less than a decade ago, it accounted for more than half of all global cases. The last case of wild polio in Nigeria was reported in 2016.
Polio, or poliomyelitis, is a disabling and life-threatening disease caused by the poliovirus. The virus spreads from person to person and can infect a person’s spinal cord, causing paralysis. In the early 20th century, polio was one of the most feared diseases in industrialised countries, paralysing hundreds of thousands of children every year. Soon after the introduction of effective vaccines in the 1950s and 1960s, polio was controlled and practically eliminated as a public health problem in those countries.
It took somewhat longer for polio to be recognised as a problem in the developing world. Lameness surveys during the 1970s revealed that the disease was also prevalent in developing countries. As a result, during the 1970s, routine immunisation was introduced worldwide as part of national immunisation programs, helping to control the disease in many developing countries.
Rotary International launched a global effort to immunise the world’s children against polio in 1985. The establishment of the Global Polio Eradication Initiative (GPEI) followed in 1988. These efforts led to a 99% decline in the global incidence of polio. However, social, cultural, religious, and political factors hindered the eradication of wild polio in Nigeria.
The controversy surrounding the safety of the oral polio vaccination in northern Nigeria contributed immensely to the delay that led to continued infectivity of children with the poliovirus. Some of the delays to eradication were attributable to eccentric views upheld by parents who refused vaccination for their children due to religious, traditional, and superstitious beliefs. That is beside the initial vaccine boycott following rumors of contaminants likely to be carcinogenic and general misunderstanding about the possibility of developing polio after vaccination. Additionally, there was a lack of community involvement, information dissemination and disregard for cultural beliefs and norms.
Polio eradication in Nigeria took so long because challenges such as political instability, ethnic violence and rough terrain persist. The Boko Haram insurgency claimed the lives of nine polio vaccinators in high-risk northern Nigeria. The supplementary implementation activities in localised areas continue to be inefficient, while antivaccine sentiments still echo within the communities. Furthermore, children who live in border settlements are known to carry a different strain of poliovirus. That highlights the possibility of cross-border spread. In these hard-to-reach areas, only about 53% of children aged 12 -23 months received three doses of the polio vaccination.
But we must pause to ask: how accurate is the data regarding wild polio in Africa? Four cases of wild poliovirus infection (WPV1) were detected in July 2016 in a remote and security-challenged area of Borno State in northeastern Nigeria. This discovery was made two years after the WHO removed Nigeria from the list of polio-endemic countries and put Nigeria back on the list as having a strain of WPV1 that was in circulation but was undetected since 2011. In 2012, cases appeared in three countries that had reported eradication. The virus strain involved was determined to have been imported from Nigeria.
Also, an initiative created by a coalition between the national polio program and the Nigerian military to reach inaccessible areas named Reaching Every Settlement Initiative was able to provide immunisations to approximately 99.6% of all partially accessible settlements at least once by February 2020. This means that some children are yet to be reached.
Concerning laboratory poliovirus containment, the destruction of all potentially infectious poliovirus substances has taken place in all 47 African countries where cases were present. In 2018 South Africa received an initial ertificate of participation per the Containment Certification Scheme to retain poliovirus infectious materials in their laboratories. Some laboratories opt to retain infectious agents for the purpose of research. The certificate of participation is only awarded to facilities in countries that have demonstrated compliance with the required safeguards for the containment of polioviruses.
Hopefully, there will not be a repeat of the case of Dr Henry Bedson who, in 1978, stored the smallpox virus in his laboratory at the University of Birmingham that led to the death of a medical photographer. Janet Parker, who occupied the darkroom above the laboratory, was infected with the smallpox virus two years after its eradication. This tragedy underscores the dangers of stored viruses due to their inadvertent potential to cause harm.
It is important to remember that polio anywhere is polio everywhere.
Despite interventions with childhood immunisations, sub-Saharan Africa still records over two million deaths from vaccine preventable diseases (VPDs) annually. Nigeria remains a contributor to global childhood deaths. Although significant factors such as child, parental, socioeconomic and political barriers continue to impede immunisation programs, applying the aggressive approach taken on polio to other VPDs will increase access to routine immunisations.
A synergistic strategy is necessary to address the peculiarities of the region, that will assure progress towards the prevention of the mortality and morbidity associated with polio and VPDs. As seen with polio eradication programs, continuous, tenacious and concerted efforts will be needed to ensure the success and efficacy of public health programs.
The opinions expressed in this article are those of the author(s) and do not necessarily reflect the views of SAIIA.
(Main image: UNICEF health consultant Hadiza Waya tries to immunise a child during vaccination campaign against polio at Hotoro-Kudu, Nassarawa district of Kano in northwest Nigeria, on 22 April 2017. The World Health Organization said 116 million children are to receive polio vaccines in 13 countries in west and central Africa as part of efforts to eradicate the disease on the continent. - Pius Utomi Ekpei/AFP via Getty Images)

domain: biology


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Communicable Disease Center, Public Health Service, United States Department of Health, Education, and Welfare, George Williams Hooper Foundation for Medical Research, University of California, San Francisco, 18
In broth cultures of 10 strains of Pasteurella pestis, 3,4-dimethyl-5-sulfanilamido-isoxazole (Gantrisin, sulfisoxazole) in concentrations of 8 to 16 times less than that of 2-sulfanilamidopyrimidine (sulfadiazine) produced a similar degree of bacteriostasis. Against the same strains of plague, chloramphenicol was 16 to 32 times more inhibitory than thiocymetin. Chloramphenicol exerted a marked antibacterial action at a concentration of 2.5 microgram/ml. as compared with about the same action for 1.3 mg./ml. of sulfisoxazole. Thus in vitro chloramphenicol was about 20 times more potent than thiocymetin, 500 times more than sulfisoxazole, and 5,000 times more than sulfadiazine. Since the mechanism of action of the synthetic antibiotics differs from that of the sulfonamides, the two types of drugs are not comparable. This difference is illustrated by the fact that sulfadiazine proved to be the most effective among these chemicals for experimental plague prophylaxis in laboratory mice, whereas chloramphenicol was the best therapeutic agent. The in vivo order of efficacy was chloramphenicol, sulfadiazine, thiocymetin, and sulfisoxazole. The lower therapeutic value of sulfisoxazole compared with sulfadiazine, and of thiocymetin compared with chloramphenicol is probably due to more rapid excretion by the kidneys.


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We have a new forum and it needs your help! Homebrewing Deals is a forum to post whatever deals and specials you find that other homebrewers might value! Includes coupon layering, Craigslist finds, eBay finds, Amazon specials, etc.
Hey guys, I decided to give making sake a try and document it to reference for future batches, learn along the way, and maybe help others get a start. I really enjoy the taste of the drink and hope to make this a routine in the wintertime like they do in Japan. It’s all about temperature...
Hello everyone! Sake is a delicious drink that is drenched in history, strict tradition and touted as having a process that is riddled with complicated steps that is hard to follow. This makes good traditional Sake making a hard brew hobby to get into. I want to help you dive into the process...
I'm hoping to dip my toes into sake brewing (in a big way).
This seems like great instructions for the sake process:
The recipe states that you need a steamer that can steam 15 lbs of rice at once in 2 levels. Does anyone have...
I'm about to make rice wine by mixing koji to steamed rice.
I bought koji in the form of this rice that already contains koji.
I still can't figure out if I have to mix dry koji to steamed rice of if I have to soak the koji first.


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Overwatch 2 can borrow one of the most common gameplay features of Apex Legends, however, if it does, the feature will not be pure duplication. Most particularly, director Jeff Kaplan of Overwatch 2 has revealed that the team of Blizzard are well aware and are currently investigating and playing with the famous pinging mechanism of Apex Legends. Kaplan doesn’t know, but the group is talking about doing something that is similar to the Apex Legends ‘ ping system. Whether this trial would translate to an actual game playing element in the future.
Sure, Kaplan responded, when asked about if Blizzard would add a ping-system to the series on YouTube channel Samito. “We’ve got a great lead UI programmer. We’re awesome. His name is Junho Kim and last week he spoke to me about having to do again experimentation with a ping Device, “said Kaplan.” We both liked their ping device and thought it was fantastic when the Apex Legends came out… Expect to test from us. You remember that Blizzard used to mess around by adding a pinging-esq feature to Overwatch, but they were eventually unable to render anything they thought fit the hero-shooter. That said, it seems like the group has some thoughts about how the sequel can be handled.
PS4, Xbox One, Ios, and Nintendo Switch are under development for Overwatch 2. There was no indication at the time of the release, or if a game for the next generation of consoles was expected. For more updates, gossip, leakages, press and game data, please have a look at our full coverage of the title right here.
“In Overwatch 2, players will take on the identities of the world’s heroes in competitive missions that force them to team up, power up, and fight together against an unprecedented epidemic of threats around the globe,” reads an official review of the game. “Players will also fight each other in the next iteration of competitive Overwatch play, that takes forth existing players’ achievements and loot collections and includes the latest complete Overwatch roster, a new generation of protagonists, new globally recognised maps that expand the reach of the game, a new Push map style, and more.”
Overwatch 2 release date?
There is no official Overwatch 2 release date announced by Blizzard, however, many rumors have speculated around the Bizzard community.

domain: entertainment


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If you or a liked a single has a gambling issue, you can possibly understand the title of the post. Still left untreated, a significant gambling behavior or severe gambling addiction can develop remarkable pain for the gambler or the household of the gambler.
What happens when this dependancy goes untreated? Do things keep the identical for the gambler, or does it get worse? Research has revealed that things in fact get even worse for the gambler. Each aspect of life can start off spiraling downward in all areas of the gamblers’ life.
The regions of the addicted gamblers’ lifestyle that are affected contain the social, psychological, physical, religious, psychological, and financial locations of lifestyle. All of these areas of lifestyle can turn out to be impacted when the gambler continues to gamble obsessively and compulsively. This can actually generate a higher degree anxiety and incomprehensible demoralization.
The person with the gambling issue commences to shed buddies simply because gambling becomes the main romantic relationship. Social isolation occurs with equally households, close friends, and a feeling of neighborhood gets dimininished.
When this addiction goes untreated, the psychological consequences are massive. Out of management gambling contributes to despair, anxiety, sadness, and indifference in the addicted gambler. Depression, anxiety, and anxiousness can turn into so serious, that this can end result in suicide. Gambling has the optimum suicide price of all addictions several moments more than.
The physical repercussions of an untreated gambling illness are a result in for concern. When a person is obsessed with gambling and has a compulsive gambling addiction, this can impact the actual physical well being of the gambler. Usually, when a person is addicted to gambling they neglect all factors of their health. The overall health of the gambler deteriorates, which contributes to deficiency of self-care, melancholy, poor nourishment, and absence of snooze.
The consequences of an untreated gambling are numerous mentally for the gambler. Lack of inspiration, indifference, and absence of concern for important items can impact a compulsive gambler. When a persona is in the grips of a gambling dependancy, considering is not rational. The primary obsession is on gambling, or when the gambler can place his or her following guess. When แทงบอล occurs, contemplating is compromised, as nicely as values. It is challenging to consider rationally and be mentally very clear when the most critical point is sitting down in front of a slot device.
When a individual is having difficulties with a severe gambling dilemma, their non secular existence is truly compromised. When a person is religious, there is a connection in between the particular person and the entire world all around them. Spiritually may possibly also consist of a connection with a greater energy or a electrical power greater than on their own. This can not happen in the grips of a gambling dependancy, as the primary connection is with the gambling itself.
The monetary repercussions of an untreated gambling dysfunction are huge and can not be understated. The devastation below is way too enormous to describe, as a lot of gamblers have gotten into these kinds of significant gambling credit card debt that it is truly incomprehensible. Numerous gamblers and their families have misplaced their houses, and maxed out credit cards. Bankruptcy is quite widespread for those with a gambling relevant difficulties.
It is hoped that these implications of gambling problems can support you comprehend how an untreated dependancy to gambling has the power to destroy lives.
Fortunately, there is aid for a gambling habit and individuals can quit gambling and reclaim their life. The downward spiral of this dependancy is really stoppable with the proper gambling help.


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A beach home or condo can become a profitable investment in the right location. Condos generally make great investments or rentals and often fare better than other types of rentals. Moreover, it is easier to market a beach house, meaning your property is less likely to be unoccupied. Buying a beach house might be the best investment in 2023.
In 2023, the rental property market appears to be moderately competitive. Many of the country’s hottest property markets are in the Northeast. As a result, investors are looking at other parts of the nation where buying rental real estate can be relatively affordable.
The lack of newly constructed condo units increases the chance of finding occupants quicker. No matter how inflation impacts rental prices, prospective homeowners remain tenants for a long time due to the barriers to property ownership.
It is easy to make money from rentals, especially if it is a seaside condominium. Beach condos are the best attractions for tourists and people looking for vacation homes. An oceanfront condo drives higher rental income than those not providing something similar. The surging demand from 2021 makes it possible to charge higher and increase profits simultaneously.
Owning a beach condo can be one of your smartest financial investments as the market is undersupplied and high in demand for vacation rentals. Considering short-term rentals can maximize your income from rental properties. To make a good return in 2023, let’s consider location and other aspects of the rental housing market.
Top 5 Coastal Ppots for Buying a Beach House
Atlantic Beach, North Carolina: Charming Southern Hospitality
Welcome to Atlantic Beach, North Carolina, where sun, sand, and surf combine to create the perfect vacation getaway! This charming coastal town has so much to offer, making it an ideal place to buy an investment or vacation home.
First and foremost, Atlantic Beach boasts some of the most beautiful beaches on the East Coast. Picture yourself strolling along the soft, golden sands, with the sparkling Atlantic Ocean stretching before you. Whether you’re looking to relax under an umbrella with a good book or try your hand at thrilling water sports, the beach here has something for everyone.
But the fun doesn’t stop at the shore. Atlantic Beach is a haven for outdoor enthusiasts. Explore the pristine waters on a kayaking adventure, go fishing for the catch of the day, or take a boat tour to spot dolphins frolicking in their natural habitat. With its stunning natural beauty, Atlantic Beach is truly an outdoor lover’s paradise.
If you’re a history buff, you’re in for a treat. Fort Macon State Park, a historic Civil War fort, stands proudly on the island and offers a fascinating glimpse into the past. Explore the fort’s underground tunnels, learn about its military significance, and enjoy panoramic coastal views from its ramparts.
When it comes to dining, Atlantic Beach doesn’t disappoint. Indulge in fresh, succulent seafood caught right off the coast in cozy waterfront restaurants. From delectable shrimp scampi to mouthwatering crab cakes, the local culinary scene will tantalize your taste buds and leave you craving more.
To reduce the upfront costs, you must bring home prices as low as possible and Atlantic Beach is a desirable source of budget-friendly condos. The median price is $500K. The town is known for its abundance of public seashores and friendly atmosphere.
Atlantic Beach is a town located in Carteret County, NC. Some say it is the finest beach town, central to many east coast cities like Washinton, DC, Baltimore, and Raleigh.
Ocean City, Maryland: An Exciting Beach Town Close to DC
Get ready for an unforgettable beach vacation in Ocean City, Maryland! This vibrant coastal town has everything you need for an incredible getaway.
First and foremost, Ocean City is famous for its pristine beaches. Miles of soft, sandy shores beckon you to soak up the sun, build sandcastles, or take a refreshing dip in the sparkling Atlantic Ocean. Ocean City’s beaches have it all, whether you’re a beach bum or a thrill-seeker looking to try water sports like paddleboarding or jet skiing.
But the fun doesn’t end at the shoreline. Ocean City is a bustling hub of excitement. Stroll along the iconic boardwalk, filled with amusement parks, arcades, and delicious treats like funnel cakes and saltwater taffy. Take a spin on the Ferris wheel for stunning ocean views, or catch a live performance at one of the open-air stages.
For nature lovers, Assateague Island National Seashore is a must-visit. Just a short drive from Ocean City, this pristine barrier island is home to wild horses that roam freely along the beach. Explore the untouched dunes, go birdwatching, or kayak through tranquil marshes for a truly immersive outdoor experience.
Foodies will rejoice in Ocean City’s culinary scene. From fresh seafood platters to mouthwatering crab feasts, the local restaurants serve up coastal delights that will leave your taste buds wanting more. Don’t forget to try the iconic Maryland crab cakes, bursting with flavor and served with Old Bay seasoning.
Ocean City’s eclectic shops and boutiques have you covered if you’re in the mood for some retail therapy. Browse through beachwear, unique souvenirs, and local artwork, and find the perfect memento to commemorate your vacation.
Ocean City is also known for its lively events and festivals. From the famous White Marlin Open fishing tournament to the Sunfest music and arts festival, there’s always something happening here. Join in the fun, dance to live music, and create unforgettable memories.
With its friendly atmosphere and welcoming locals, Ocean City embraces visitors with open arms. Prepare to be greeted by warm smiles and receive insider tips to maximize your stay.
Besides the ideal location from DC, Ocean City has several affordable housing opportunities that aspiring home buyers are thrilled about. Its prime location on the beach is one of the significant reasons why investors are likely to succeed in the rental business.
Ocean City is home to endless entertainment and luxurious condo buildings looking over the majestic Atlantic. The fantastic beach condos aren’t easy to come by until you’ve checked Golden Sands’ new listings. The average price of condominium units hovers around $700K.
Galveston Texas: A Treasure Trove
Get ready to experience the charm of Galveston, Texas! This coastal city is a hidden gem that perfectly blends history, culture, and beachside bliss.
Galveston’s sandy shores are simply breathtaking. Miles of pristine beaches invite you to soak up the sun, build sandcastles, or take a refreshing swim in the turquoise waters of the Gulf of Mexico. Galveston’s beaches have it all, whether you’re looking for relaxation or thrilling water activities like surfing and paddleboarding.
Beyond the beach, Galveston’s rich history comes to life. Explore The Strand Historic District, a treasure trove of Victorian architecture, unique shops, and delicious dining options. Visit the iconic Moody Mansion or journey back in time to the historic Bishop’s Palace.
Galveston’s vibrant arts and culture scene is a treat for the senses. Discover local art galleries, catch a live performance at The Grand 1894 Opera House, or immerse yourself in history at the Galveston Railroad Museum.
Food enthusiasts will delight in Galveston’s culinary offerings. Indulge in fresh seafood at waterfront restaurants, savor mouthwatering Gulf Coast cuisine, or enjoy a leisurely brunch with a view. Don’t forget to try the famous Gulf oysters!
For family fun, head to the Galveston Island Historic Pleasure Pier. This iconic amusement park offers thrilling rides, classic carnival games, and delicious treats, guaranteeing a day of laughter and excitement for all ages.
Galveston’s warm and friendly locals add a special touch to your visit. Their hospitality will make you feel right at home, and their recommendations will ensure you make the most of your stay.
So, whether you’re seeking sun-soaked relaxation, historical exploration, delicious cuisine, or family-friendly adventures, Galveston, Texas, has it all. Pack your bags, bring sunscreen, and prepare for an unforgettable coastal vacation in this captivating city.
Galveston is a just 50 miles from Houston and an easy flight from the east coast. The amenities of a big city and a private lifestyle make it a great resort destination and place to call invest in.
Galveston invites investors to explore any real estate, from condos to cottages. Investors have plenty of options before committing to any contract. Most noteworthy is that the median price of seaside condos is often less than in other areas of the country.
Sandbridge Beach, Virginia: Close to DC and Yet A World Away
Welcome to the serene and picturesque Sandbridge Beach, Virginia! Located south of the Virginia Beach boardwalk, this area perfectly blends natural beauty and tranquility. And best of all, it’s an easy drive from Washington, DC, Richmond, and Baltimore.
Prepare to be mesmerized by the stunning beaches of Sandbridge. Imagine long stretches of soft, powdery sand and rolling waves inviting you to relax and unwind. Whether you’re looking for a peaceful beach walk, a thrilling surf session, or simply basking in the sun, Sandbridge Beach is a haven for beach lovers.
Nature enthusiasts will be delighted by the surrounding wildlife and outdoor activities. Explore Back Bay National Wildlife Refuge, a pristine sanctuary where you can hike, bike, or kayak through marshes and witness many bird species. For a touch of adventure, try your hand at fishing or embark on a dolphin-watching excursion.
Sandbridge Beach is perfect for those seeking a respite from the bustling crowds. This coastal retreat offers a sense of seclusion and serenity, allowing you to unwind and connect with nature.
Although Sandbridge Beach offers a peaceful atmosphere, nearby Virginia Beach provides a vibrant contrast. Just a short drive away, you can explore the lively boardwalk, indulge in delicious cuisine, and enjoy exciting entertainment options.
The market may be more competitive than others, but if you buy a condo in Sandbridge, your property will yield passive income almost year-round and you can use the property yourself very easily.
The median price of condominiums lies between $500K and $550K, while single-family homes will be higher.
North Myrtle Beach: A Warm Getaway and Great Investment Opportunities
Welcome to the sun-soaked paradise of North Myrtle Beach, South Carolina! Nestled along the pristine coastline, this captivating destination offers a myriad of delights for beach lovers and adventurers alike.
Prepare to be enchanted by the exquisite beaches of North Myrtle Beach. Immerse yourself in the soft, golden sands and let the gentle waves caress your toes. Whether seeking a tranquil escape or thrilling water sports like parasailing and jet skiing, North Myrtle Beach’s shoreline caters to every desire.
Nature enthusiasts will revel in the coastal beauty and abundant wildlife. Explore the enchanting salt marshes and nature preserves, where you can spot unique bird species and discover the vibrant ecosystem. Embark on a fishing excursion or take a sunset cruise for an unforgettable experience in the sparkling waters.
North Myrtle Beach offers a delightful blend of tranquility and excitement. Discover the charm of Barefoot Landing, a premier shopping and dining destination featuring boutiques, eateries, and live entertainment. Indulge in delectable seafood at waterfront restaurants or savor Southern cuisine that will tantalize your taste buds.
Families will find endless fun in North Myrtle Beach. Explore the thrilling amusement parks, embark on a pirate adventure, or enjoy a round of mini-golf in the captivating seaside setting. With various family-friendly activities, North Myrtle Beach is the perfect destination to create lasting memories.
North Myrtle Beach is in Horry County, SC, bordered to the southwest by Briarcliffe Acres. The location balances the beauty of the beaches, the excitement of vacation activities, and residential homes, including thousands of condos.
What is the right to buy a beach property?
It is the ideal time to a buy a rental property when there is a slowdown in the market. This is because sellers are anxious to sell at that time. Buying at the beginning of fall, typically September and October, would be prudent for a coastal market. Some prefer summer to purchase real estate to start making money immediately.
By exploring the enchanting landscapes and captivating communities showcased in this guide, astute investors can discover the hidden gems that promise a blissful beachside lifestyle and substantial returns on their investments. These coastal destinations boast the perfect blend of natural beauty, economic growth, and burgeoning tourism, making them prime locations for savvy condo investments.
If you’re in the market for a home in the Washington DC area, contact one of our experienced realtors at Eng Garcia and let us help you today.


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This winter, most people are spending the holidays at home or somewhere nearby. And like many others, you’ve probably taken up a new hobby recently, like knitting or bread making. But if you haven’t tried cooking yet, Jägermeister is here to give 19 delicious reasons why you should give it a go.
You probably know this iconic herbal liqueur for its 56 botanicals and smooth taste, but this holiday season celebrity TV chef and long time Food Meister Chef Chris Santos is here to show you the brand with the signature green glass bottle can be used for more than pouring a round of ice cold shots. And the instructions on how to do so are available right here at the Jägermeister Party Hotline.
This classic cookie recipe goes a step further by glazing these treats with a blend of melted peanut butter and Jägermeister Cold Brew Coffee. Who knew you Jägermeister could even improve your holiday cookies?
Maple syrup and smokey bacon always taste great together. Now imagine how good that sweet and savory combination would taste with some chocolate and Jägermeister Cold Brew Coffee mixed in. With such unique ingredients, these fluffy pancakes are just as appetizing as they are interesting. Trust us.
Who doesn’t love tater tots? And who doesn’t love nachos? So who wouldn’t love a deliciously cheesy plate of tater tots smothered with crispy bacon, creamy avocado, and charred jalapeños topped with the taste of ice-cold Jägermeister? We know we would.
Hearty and packed with flavor, this twist on a breakfast classic will shock your taste buds with its mix of toe-curling sweet and sour spices. Made with skirt steak, tomato jam, and a runny, sunny egg, Jägermeister just created the perfect way to start the day.
A few delectable donuts and savory s’mores are the perfect way to end a rich, holiday meal. Now, add the taste of Jägermeister Cold Brew Coffee to these nostalgic desserts and watch your holidays go from good to unforgettable.
You can never go wrong with some of BBQ chicken wings on the table. And adding Jägermeister’s special smoky recipe to that mix certainly won’t disappoint. These small bites paired with a cold drink are sure to make for a mouthwatering meal your friends will wish they could eat with you.
Who doesn’t want a good drink to wash down an even better meal? This sweet treat is the perfect fusion of Jägermeister’s original taste, intense cold brew coffee, Bourbon, espresso, and a touch cream. Mmmm.
For recipes 8—19, text "Hi..." to 833-587-0256 now to take your cooking at home to the next level or visit the Jägermeister Party Hotline!


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Mossgreen has held the position of leading specialist auction house in the field of Oceanic & Tribal Art for many years with industry veteran, Bill Evans, offering over 35 years of experience.
Oceanic & Tribal Art features as part of the annual, tightly curated Australian Indigenous Art auctions at Mossgreen.
Forthcoming auctions from this category
Head of Early Aboriginal & Oceanic Art
Or call +61 3 9508 8888


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Robinhood Layoff Costs, Q2 Losses Won’t Delay Crypto Product Launches
The company seeks to use its $6 billion balance sheet to potentially acquire companies at attractive valuations
Robinhood co-founder and CEO Vlad Tenev | Photo by Lauren Sopourn for Blockworks
- Robinhood’s 23% headcount reduction announcement came a day before it reported a net loss of $295 million in the second quarter Wednesday
- Company estimates a nearly 10% decrease in expenses in 2022 from the prior year despite restructuring costs from two rounds of layoffs
Though Robinhood is set to take a hit on its latest round of layoffs — a sum of $45 million to $60 million — executives said the cuts would not impact the rollout of additional cryptocurrency trading products.
Such charges from Robinhood’s first round of layoffs in April amounted to $17 million. Even still, the stock and crypto trading platform expects its total 2022 operating expenses to be roughly $1.7 billion, a nearly 10% decrease from the year prior.
Robinhood CEO Vlad Tenev wrote in a blog post Tuesday that the company would be reducing the company’s headcount by 23% in the wake of reduced customer trading activity and assets under custody. The changes are particularly concentrated in Robinhood’s operations, marketing and program management divisions.
The layoffs are set to decrease Robinhood’s workforce to 2,600 staffers.
“At this new level, we believe we are appropriately staffed to be cost-efficient, while continuing to deliver great service and innovation for our customers,” Chief Financial Officer Jason Warnick said during the company’s Wednesday earnings call.
Though Tenev said the company would move to a structure in which general managers will assume broad responsibility for Robinhood’s individual businesses, he did not share details.
A Robinhood spokesperson declined to comment on how the restructuring will impact the company’s nascent crypto business.
Sam Wellalage, founder of WorkInCrypto.Global, said he expects about a third of the layoffs to stem from digital asset-focused roles.
“Most people who are losing jobs in crypto are snapped up by fintech and TradFi [companies],” Wellalage told Blockworks. “We also see a lot of hyper-growth startups snapping up these candidates.”
Robinhood’s declaration of another round of layoffs came the same day the New York State Department of Financial Services (NYFDS) imposed a $30 million penalty on Robinhood’s cryptocurrency division due to purported violations of anti-money laundering, cybersecurity and investor protection regulations.
Results and product plans
While transaction-based revenues for options and equities decreased by 11% and 19% quarter over quarter, respectively, digital assets proceeds increased by 7% to $58 million.
The company booked a net loss of $295 million in the second quarter after tallying a net loss of $392 million during the first three months of the year.
Monthly active users in June decreased 1.9 million from the previous month to 14 million. Assets under custody were down 31% quarter over quarter to $64.2 billion, primarily driven by lower asset valuations.
The price of Robinhood stock closed Wednesday at $10.31 — up 11.7% during the day’s trading session. The stock is down 44% so far in 2022 — but up nearly 23% from one month ago.
The company opened up its crypto wallet product in April to two million more eligible users. It also revealed during the quarter its plan to introduce a non-custodial wallet later this year. The standalone app is set to allow customers to trade and swap crypto, with no transaction fees, while maintaining full custody.
Executives added on Wednesday’s call that Robinhood is looking to introduce additional cryptocurrencies in a “deliberate” way as the company vies to compete with crypto-native incumbents such as Coinbase and FTX.
Asked whether Robinhood could be acquired, Tenev said, “In one word, no.”
Added Tenev: “We actually see opportunities, particularly in this market environment, to leverage the balance sheet that we have — that’s about $6 billion — to acquire companies to accelerate our roadmap.”
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