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Friday, July 25, 2008
Google Earth is Cool
So out of curiosity I searched for Hartford. I figured that there was going to be nothing, as I am used to Hartford being a hole where everything closes early and is ignored by Google. Of course I had forgotten about how Google Streetview finally included Connecticut.
Well, I was pleasantly surprised. Not only was the XL center drawn in 3D, but the Hartford 21, other buildings downtown, and the capital building (shown here) were also drawn in 3D. Hartford still stinks ... but GO GOOGLE!


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Products and ServicesAnimals
Locally Owned & OperatedTreatments
General Medicine, Preventive Medicine, DermatologyService Options
Mobile ServiceInsurance Accepted
PetCare Insurance Programmes, Veterinary Pet InsuranceServices
About Dr Evan Kendon BVSc
Convenient Mobile Veterinary Services to all Christchurch suburbs.
Dr. Evan Kendon is a mobile vet whom has provided over 25 years of quality healthcare to Christchurch pets.
You know the hassle and stress of travelling to a vet's clinic ( for both you ... and your pet ), or you may find doing so wastes your precious time .... so do yourself, and pet a favour .... and get Dr. Kendon to come to you for a relaxed, convenient veterinary house call.
You can trust Dr. Kendon, a professional with years of experience, to deliver friendly and competent veterinary services. His expertise ranges from pet vaccinations, feline desexing, and general companion animal medicine to light surgery, euthanasia, and feline dental work.
Dr. Kendon can also give effective nutritional, behavioural and training advice.
Call Evan (03-3793797) today for experienced, convenient and reliable veterinary care.
What makes us different
Mobile Vet, Dr. Evan Kendon comes to you! He provides a high quality and relaxed environment for your pets while they get back to optimal health. Multiple pets can be managed easily. Save time and call Dr Evan Kendon today! (You will be happy you did)

domain: medical


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Hour by Hour »
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Impact of Paul Walker crash caught on tape
You may not know her face or even her name, but you're certainly familiar with Susan Wagner's work. Channel 4 Action News anchor Wendy Bell introduces you to the local sculptor who's been molding Pittsburgh history, one stroke at a time.
There will be both public and private farewells for former South African President Nelson Mandela, who died Thursday at the age of 95.

domain: news


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Young Germans partying abroad on Europe’s beaches and ignoring physical distancing rules are becoming an increasing cause of concern at home, as coronavirus cases continue to rise across the world.
Following widespread reports earlier this month of German tourists revelling on the Spanish island of Mallorca, bars and clubs on the infamous “Bier Straße” were forced by local authorities to close.
Many Germans have since cancelled Mallorcan holidays, and are flocking instead to Bulgaria – particularly to the resort town of Golden Sands on its Black Sea coast.
Large numbers of German travellers are also ignoring government warnings issued earlier this week to avoid areas in Spain, including Catalonia, Barcelona and the Costa Brava, as well as the regions of Aragon and Navarra, due to rising numbers of coronavirus cases there.
Lothar Wieler, of the Robert Koch Institute (RKI), the government’s main advisory body on public health, called the partygoers “irresponsible”.
“It is reckless and careless to take part in wild parties,” he said during his latest update of the virus’s progress. “Young people can carry the illness back to their families, especially their grandparents.”
Footage of revellers in Bulgaria was prominent in German media on Wednesday. Particular focus was placed upon the phenomenon of “foam parties”, in which holidaymakers wearing large swimming rings – apparently to enable them to physically distance from each other – dance in pools of flying foam.
Participants have their temperatures measured before being allowed in, and are advised to drink out of their own cups rather than share them. The parties are labelled “corona-free zones” by the organisers.
However, pictures showed people dancing at close quarters, and participating in close-contact drinking games.
Bulgaria’s initial coronavirus outbreak was comparatively small by European standards, but the number of cases is rising fast. Unlike in Spain, Bulgaria has not introduced a rule requiring people to wear masks.
Nikolai Veler, a club owner at Golden Sands, told German television he was powerless to control the partying. “People are allowed to do what they like here,” he said. “I can do nothing to stop them, particularly when the government doesn’t say they must be thrown out if they’re not wearing masks.”
Earlier this month, Jens Spahn, the health minister, said he was appalled by reports of partying German tourists in Mallorca, who were blatantly ignoring Spain’s coronavirus rules, such as wearing a mask, or keeping a distance of 1.5 metres.
“I’m not a party pooper,” he said. “But this is simply not the time for that.”
According to the RKI, there are 6,500 active coronavirus cases in Germany On Wednesday, the RKI registered 684 cases over 24 hours, compared with a daily rate of about 300 to 400 for the past few weeks.
“We have been neglectful, that is the reason,” Wieler said of the “worrying” rise in cases. “We achieved so much in the past few months in Germany and were mastering the pandemic very well. We all contributed to the sinking rate of infection so as not to overload our health system. We should celebrate this success, but we shouldn’t sit on our laurels.”
He urged Germans to remember that a holiday was not an excuse to ignore the rules. “Be sensible,” he said. “Your holiday is no less important than your work or private life in terms of taking precautions.”
The RKI has 130 countries registered as high-risk areas. While Germans are strongly advised not to visit those countries, if they do they are required to go into quarantine on their return. Spahn has said the government will introduce obligatory testing for them, probably from next week.
Gerd Fätkenheuer, an infectologist at Cologne’s University Clinic ,said having reduced the rate of coronavirus Germans felt much safer now than they had three months ago. “This poses a big risk,” he told the Kölner StadtAnzeiger. “Dangers related to the virus are not being taken seriously by enough people”.
While returnees are seen as a potential problem, many see the dangers at home as just as high as abroad, if not more so.
“Family parties, weddings, meetings with friends, these are the source of the majority of cases,” said Ute Rexroth, of the RKI. “Holidaymakers returning from abroad are among those we’re seeing with the virus, but most new infections are actually occurring in Germany”.


Triple C Housing hosted a Ground Breaking ceremony for their new project in New Brunswick, New Jersey on Monday April 16, 2012. The ceremony was attended by neighbors, City, County and State officials as well as Triple C Board Members and staff. The Promise House will provide permanent supportive housing for ten (10) persons at risk of experiencing homelessness who have special needs.
The housing will be a multifamily building with seven (7) studio units and three (3) one bedroom units as well as a unit for a site superintendent. Promise House will have a community room, space for services and property management, a laundry room and patio. The site is within close proximity of downtown New Brunswick.


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on April 01, 2016
Dream Spell is the first short story in Sarah Doughty's Earthen Witch World Shorts novella series.
This story puts a new spin on the phrase "chasing your dreams."
I enjoyed this one. Honestly, not as much as her full length novels, but that's probably because this one lacked the great action scenes that Sarah writes so well. Still, it packs quite an emotional punch in so few pages. Nicely done, Sarah. Keep them coming!

domain: entertainment


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Flashing a Euro window sill
Gutmann and a number of other German companies make an aluminum sill w/ end caps designed for use w/ Euro tilt turn windows. Have you seen any flashing details for installation of a Euro sill in a wood frame structure w/ rigid insulation, rain screen and siding?
GBA Detail Library
A collection of one thousand construction details organized by climate and house part

domain: design


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When somebody sings trip in Greece, the very first thing that comes up in most minds is sandy seashores and glowing clear water. With a 13,676 km lengthy shoreline, there’s actually a fjord that fits all tastes. Nonetheless, Greece can also be recognized for its capital, Athens; balcony large metropolis that by no means sleeps. Aside from the numerous fancy inns obtainable, there’s additionally one other property comparable to studios or residences for extra income. For the traveler who needs to expertise this metropolis shut and work sweat on the identical time, the easiest way is to journey.
There are a lot of cyclists who’re prepared to take the problem abroad. Greece has many cyclists of its personal and a plethora of businesses renting bikes or providing bikes. All it’s a must to do is determine the way you need to do it; by yourself or with a bunch. As a result of Athens, like a giant metropolis, has fixed visitors disturbances, biking will definitely provide the freedom you might be searching for. Upon getting researched your maps, you’ll be able to zip out and in of visitors and uncover the secrets and techniques of town that’s out of monitor.
Proper within the coronary heart of this contemporary metropolis lie the ruins of historic civilization. As you might be heading in the direction of downtown, you can’t miss the majestic Acropolis hill, the world's heritage web site. Sitting proudly on the high of the hill is the well-known column of the Parthenon, which was inbuilt honor of the Divine Athena. The heights and surrounding areas abound with the wonderful remnants of the previous, comparable to the traditional theater of Herod Atticus, Resurrection and Agora, the market of historic Athens. All of the roads and slender trails lead you to those proud remnants and reveal the secrets and techniques of distant properties set amidst a contemporary metropolis.
On the way in which you can find individuals and locations to satisfy you in your journey. There are a lot of roads which might be outdoors the boundary of vehicles and extensive trails which might be bike trails. After all, within the excessive season, the streets are dotted with individuals from all of the existence that come right here to see the sights and expertise the tradition. The cafes and plenty of eating places float with vacationers, whereas locals, most of whom are in English, are pleasant and welcome. Numerous artists and musicians are additionally there to entertain the oldsters and shops that spill with stunning souvenirs.
Supply by S Pappas

domain: geography


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The Embassy of the Grand Duchy of Luxembourg to the Republic of Poland kindly invites you to save the date of 17 May 2018 at 09:30 for the Third Luxembourg-Poland Roundtable on Logistics “New Challenges and Opportunities for Luxembourg-Poland Cooperation in the field of Logistics (Road, Rail/Multimodal, Air and Maritime)” with the confirmed participation of the:
- Luxembourg Chamber of Commerce
- Luxembourg Cluster for Logistics
- Luxembourg Maritime Cluster
and the Polish International Freight Forwarders Association as well as representatives of renowned logistics firms from both Luxembourg and Poland. This event is organized by the Embassy of the Grand Duchy of Luxembourg to the Republic of Poland and the Luxembourg-Poland Chamber of Commerce, and it will take place at the Embassy’s premises.

domain: economics


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We are enjoying a rare - nothing to do - weekend. The weather is decent. In fact, yesterday, my son got to play outside in the early afternoon with friends. This is certainly a great part of living in this area. Warmer Winters can be good after all. I mean, I'd love a great big snow... but it may not happen.
Most of you who read my blog know that I love card-making. If you are a newer reader... paper crafting is a big part of who I am. I love to create. When I saw Purrfect Friend Clear Stamp Set at SweetnSassy Stamps, I knew I had to have it. I don't often buy clear stamp sets because digis are so much less expensive, but I treated myself and I don't regret it. lol
I just love my kitty Fred. Well, technically he's Marque's kitty. Fred is red & white and he's a big, mellow guy. And when I colored these two images, we had our gray and white tabby that we were fostering. We got her when she was three weeks old. We called her Annie. She is at a friend's house and enjoying being spoiled no doubt.
Anyway, here are the cards I made from this set. I hope you like them!
Above Image - colored with Copics. The Background Paper is from the Polka Dot
Pad PTI put out years ago. I also used PTI Kraft and Black on this one. The DP is from
Creative Memories about 10 or so years ago. I have quite the stash of old stuff.
Buttons are random and from my button bin. Ribbon is PTI Brown Twill.
Above Image - colored with Copics. The Background Paper matting is
something I put together years ago for who knows what, and it just worked.
I love when that happens. Prima Flowers, Twine & Ribbon (SU) make it a fun card.
I hope you have a great Saturday.
Be safe, wherever you are.
Hugs & Blessings,

domain: artistic


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Hebei Xiangyi International Trading Co., Ltd
Plastic Cap Description
Used for disposable vacuum blood collection tube
Made of high density PE material.
PE plastic cap for disposable vacuum blood collection tube
During the 55 years' development, First Rubber now occupies 150,000 square meters factory area, with production ability of 10 billion medical and pharmaceutical use rubber stoppers annually,


Intel’s future growth
In 2Q15, Intel’s (INTC) DCG (Data Center Group) and IoT (Internet of Things) segments grew to $3.9 billion and $559 million, respectively. Their revenue rose by 10% and 15% in 2Q15. Together, DCG, IoT, and NAND business generated ~40% of the company’s revenue while their contribution to the overall operating profit rose to more than 70%. Intel’s 3D NAND products, in collaboration with Micron Technology (MU), are making their entry into the market in 2H15.
New platforms and products could boost PC demand
In its 2Q15 earnings release, Intel stated that the company has qualified its sixth generation Core products, Skylake, for production. Skylake is Intel’s next generation processor built on a 14 nm (nanometer) manufacturing process. It’s targeted towards the PC market. Intel’s CEO Brian Krzanich said, “We expect the launches of Skylake, Microsoft’s Windows 10 (MSFT) and new OEM systems will bring excitement to client computing in the second half of 2015.” Intel believes that its collaboration with Microsoft to enhance the Windows 10 experience on tablets, combined with Skylake’s arrival, will revive demand in the PC market.
Intel also expected that the introduction of its third 14 nm product, Kaby Lake, will be in 2H16. Kaby Lake is built on Skylake micro-architecture “but with key performance enhancements.” Cannonlake is Intel’s first 10 nm product. It’s expected to launch in 2H17. The above-mentioned additions to its product roadmap are expected to enhance Intel’s performance and smooth the transition to 10 nm adoption.
For fiscal 3Q15, Intel expects revenue of $14.3 billion, plus or minus $500 million. Intel reduced its full-year capex forecast for 2015 for the second time. It lowered its 2015 capex forecast to $7.7 billion, plus or minus $500 million. Earlier, it announced a reduction of its full-year capex forecast to $8.7 billion from $10 billion in April 2015.
You can consider investing in the VanEck Vectors Semiconductor ETF (SMH) and the Technology Select Sector SPDR Fund (XLK) to gain exposure to Intel. Intel accounts for about 19% and 3.55% of SMH and XLK, respectively.


A senior Ministry of Foreign Affairs (MOFA) official was furious that, “The foreign minister’s ‘addiction to overseas trips’ is hopeless. As it is, he is ‘prospering at the expense of MOFA’s ruin.’” He had lost patience with Foreign Minister Taro Kono’s excessive foreign visits.
Indeed, Kono was traveling at a dizzying pace last month, going to Russia, Singapore, Myanmar, Bangladesh, Ecuador, Peru, Colombia, Mexico and so forth. He is also scheduled to visit the U.S. and Iceland in the second half of September and will have visited a total of 16 countries in two months.
The above MOFA official continues: “For sure, Minister Kono is no longer demanding an airplane for his exclusive use, but he always flies on first class, using up an enormous amount of funds. MOFA officials are suffering the consequences. Some of them have had to cancel overseas trips, while even bureau chief level officials are flying on economy class.”
It would have been tolerable if his frequent foreign visits contribute to enhancing Japan’s national interest, but a Kantei source says: “There are various urgent diplomatic issues, such as the territorial talks with Russia and the abduction issue, but Prime Minister Abe is ignoring the foreign minister completely.”
A reporter covering MOFA also states cynically: “Right now, only NHK reporters would travel with the foreign minister on his trips. He is dubbed the ‘satellite foreign minister.’”
The cabinet is due to be reshuffled after the Liberal Democratic Party presidential election. This reporter intimates that, “The foreign minister is backed by Deputy Prime Minister and Finance Minister Taro Aso and Chief Cabinet Secretary Yoshihide Suga, so it is widely believed that he will be retained.”
So the “satellite foreign minister” will be continuing with his overseas trips?


Pros: Blade Sharpness, Blade Material, Overall Quality, Materials, None
Cons: Handle Material, Sheath/Scabbard
Great all-around use knife
This is a relatively inexpensive option for camp, bushcrafting, or self-defense; good (but not great) for all in my opinion.I bought the BK-2 companion a few years back and was overwhelmed by its size. I wanted a smaller knife just like it, but opted for the 17 rather than the 16 since I found it cheaper and it fits my overall purpose-driven knife criteria a bit better.I've removed the finish and put micarta scales with spacers on it and I've never felt a better feeling and handling knife after doing so.The sheath is decent quality but too long for the knife as it looks like it's made to fit the 15,16, or 17 (the 15 is the longest knife of the tweeners). I kept the sheath to go on my pack but was looking for a better belt carry option. I found from other users that the leather sheath for the buck ergohunter was a perfect fit (also for the 16) so I ordered one. It works great for the knife and feels great wearing it too.The blade is thick enough to take some pretty good abuse to dig, pry, baton, etc. if needed in a pinch, and also holds an edge better than any other 1095 steel knife I have. The grind markings are a bit obvious (but not unsightly) after removing the coating if you choose to do so (which I highly recommend).If I had to give it some cons, I would say that even though they give you two sets of handles for this knife, they're two sets of handles you're probably going to want to replace (or wrap something grippy around them). Also, I'm used to a larger choil on a knife this size for finer tasks but that's not a huge downer for me. The jimping is adequate but I would have preferred deeper grooves so I'm going to grind that out to the way I want it.I have yet to see the perfect do-all knife but this one's pretty close for the money.


4 Ranges up to 88 lb-in
Sample Diameters up to 7.5" (190 mm)
The new CAP-TNP torque meter is a precision instrument that measures OPEN and CLOSE torque values for various applications. As a cap torque analyzer, the CAP-TNP repeatedly determines bottle closure and breakaway torque. It has a wide memory capacity capable of storing 1,000 data points in addition to Average, Maximum and Minimum values. A HI-LO comparator feature can be utilized for a large batch testing to ensure overall product quality.
The CAP-TNP torque meter is USB capable for computer testing. Combined with the free Digitorq Software, additional analysis and testing can be performed.
The CAP-TNP is a portable device powered with internal rechargeable batteries or through an AC Adpater/charger. Designed with a small footprint it can easily be transferred to maximize use around the shop floor or the laboratory.
The CAP-TNP includes free software to analyze your measurement data. The software is Windows 7 compatible and requires Microsoft Excel.
- ±0.5% F.S. Accuracy
- Includes Hi/Go/Lo Limits and LED Indicators
- Displays Torque values in, lb-in, Kgcm and Nm, Ncm
- USB interface including FREE Digitorq Software
- Captures Peak Opening, Peak Closing and Average torque values (CCW, CW)
- Three (3) models offered covering small, medium and large sized containers
- One touch operation, retains up to 1000 measurements in memory
- Easy to read L.C.D.
- Rechargeable NIMH batteries and / or Universal AC adapter
- Small foot print, compact, space saver design
- Open Mode:
Max value when opening
[CCW torque direction]
- Close Mode:
Max value when closing
[CW torque direction]
- Average Mode:
Continuous torque values in real time
- Includes Traceable Calibration Certificate
- CE Certified
- 2 Year Warranty


Found an old tune (by Bonnie Cook and myself – i.e. Thenorks) last night whilst digging around… Unfinished and unheard as a result. Well unheard if you weren’t at the Music 4U festival in 2006 at least.
Leave a comment to a) tell me you like it or, b) tell me to never clutter up the internet with rubbish like this again*.
* b) comments will be deleted automatically. ;)
Listen here: Ta Da!


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A SCOUT, charity fundraiser, netball champion and sport coach all took part in the Olympic torch relay as it came to the Midlands last week.
Zach Radford from Kimberley works as a beaver leader, a cub leader, does volunteer work with the Wildlife Trust and works with rescue seals.
He carried the torch through Kirton and said: “It was the most amazing experience of my life.”
Zach’s mum, Dawn, said: “I was torn between tears of how proud of him I was and absolute joy. I was bursting with pride.
“It was brilliant. He ran all along the school children giving them the torch to hold before they lit it. It was really exciting. A wonderful atmosphere.”
Hollie Ross, also from Kimberley, ran with the torch through Calow.
She was nominated by her sister after doing 16 charity runs last year raising over £1,000, whilst training to be a nurse at the same time.
Georgia Zadins from Selston Arts and Community College carried the Olympic torch through East Markham.
The 12-year-old was nominated for her determination and achievements as a netball player, despite having bad asthma, and her overall attitude towards school work.
Teachers described has as ‘inspirational’ and a ‘model student’.
Georgia’s mum said: “She was so excited she was shaking at the start.
“She was absolutely delighted to have been nominated.”
The sport coach at Greasley Beauvale Primary School, Glenn Chambers, was also a torch bearer and ran through Mansfield.
The coach, who lives in Underwood, played football for the England and British Police football teams and later went onto manage them. In May, Glenn received a national award for services in the police force during his 30 years service.

domain: sociology


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HCC, Carbon and stainless steel
The HCC is a cooling device that allows the mixing of hot condensate with a lower temperature condensate, avoiding hammering. Condensate discharge from higher pressure lines (drip points, for instance) is often connected to low-pressure condensate lines, with lower temperatures. This sudden pressure drop will convert the sensible heat difference between the two fluid conditions into latent heat, generating flash steam.
MATERIAL: Carbon and stainless steel
Flanged EN PN16 or PN40
Flanged ASME Class 150 or 300
Others on request
MAX. OPERATING PRESSURE: 40 bar
MAX. OPERATING TEMPERATURE: 300 ºC

domain: chemistry


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I'm excited to show you the finished illustration that goes with Ringmaster Sammy that I shared with you a couple of weeks ago...
Friday, May 31, 2013
Monday, May 13, 2013
Last summer on vacation in Kansas I shot these portraits of three great guys - the Weseloh men. They're stading in front of a really cool old truck with "Weseloh Brothers" written on the side. I haven't posted this until now because I was waiting until I got prints mailed to them as a thank you for their hospitality and for all they do for our family.

domain: hobby


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Friday, August 12, 2011
Portage Public Library Moves Forward with Building Expansion
Plan for Portage library expansion moves ahead; board approves consultant for fundraising. (Portage Daily Register, 8/9/2011)
Excerpt: Portage Public Library board members threw their support and the library's resources behind a 6,000-square-foot building expansion, voting Tuesday to hire a consultant to help raise $1 million to $1.25 million through a nine-month community fundraising campaign.
"So that's a big forward step," board President Rich Davis after the vote.
Money for the expansion at 253 W. Edgewater St. would come from several sources:
• Up to $300,000 from the Bidwell Foundation, a local charitable institution that helped fund the original library building's construction with a $750,000 grant in 1995.
• Several hundred thousand dollars from the city of Portage. Library board members plan to make an appearance before the Common Council on Aug. 25 and present a case. Library Director Shannon Schultz said the idea was to pay for the expansion without new taxes.
The rest of the money would come from the community. To guide it in its fundraising efforts, the board voted to pay Madison, Ind.-based Woodburn, Kyle & Co. $90,000 plus some expenses such as partial cost of air travel. In return, the consulting company will provide its expertise as well as services and items such as volunteer training, campaign materials, a donor database, assistance in writing corporate proposals and news releases.
Board approves feasibility study for library expansion. (7/1/2011)
Board reviews estimates for expansion project. (6/22/2011)
Library expansion plans continue to develop. (2/9/2011)
Library expansion to focus on youth services. (10/15/2010)
Putting together the financial pieces for building expansion. (5/12/2010)
Library seeks community input for expansion. (1/13/2010)
Board discussion rental property options. (11/11/2009)

domain: finance


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(XBOX ONE) Insaniac Gaming -Where Gamers unite- We offer GTA V Money/RP Lobbies-- Zombies-- Roleplay. BF1 Squad Realism events--- Minecraft Servers--- Overwatch Competitive----Rainbow Six Siege Competitive---Ark Survival Evolved Server (WIP)
Welcome to the Planetary Pit Stop—a place for friendly conversation between… friends! Remember: You can check out any time you like, but you can never leave.
A forum dedicated to play by post gaming of all types, homebrew creations, rules discussion for various systems, and everything in between.
wh40k, roleplay, warhammer, #gaming, gamer, gamers, systems, shadowrun, pathfinder, writing, savage, worlds, stars, without, number, at43, rpgs, roleplaying, play-by-post, play, post, dungeons, dragons, gurps, vampire, masquerade
Welcome to The Nintendo Forum Site!
Modern Warfare 3 and Modern warfare 2 games based clan. . .
S. F. W : PS4 Gaming Online & Sporting updates
Free forum : Adult Gaming Community
Free forum : Guild HQ of chaoZ
A Troupe based Vampire: The Requiem LARP game in Huntsville, AL
Our little corner of the interweb where we discuss all things "nerdy".
Serenity Station & the Firefly Fleet are a fleet in the coming game Star Trek Online!
WBYPForums is a website that focuses on gaming and basically all around it!
wbyp, roblox, forums, youtube, #gaming, grand, theft, auto, games, free, giveaway, news, website, moderator, forum, pubg, player, unknown, battlegrounds, fortnite, csgo, counter, strike, steam, payday, deadbydaylight
Awesome gaming, and game making community!. DDNN Team Forums
Clan Dream - Online Gaming Community
Gaming community dedicated towards achieving and keeping new and old members
Official Mjolnir Gaming Combine Control Forums
Free forum : The Facebook page has now become the forum
Free forum : Gaming Community
Free forum : The perfect place for all things gaming and pop culture related. Discuss anything from Destiny 2 wishes to Mass Effect Andromeda gripes.
A Battlefield gaming clan.
A forum about My Lego Network (MLN) , LEGO Universe, and for LEGO enthusiasts. We are forum based on LEGO discussion and more, we now are organising gaming events on minecraft, Mario Kart and more!


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Re: Council fattens up pension plans, March 1.
First question is who is the Council Compensation Committee? Second question is if it was not the members of council themselves, who did this committee consult before they decided to make the retirement plan of our elected officials the most lucrative of the 20 municipalities compared? If the answer to the first question is “members of council” then they must be aware of the growing sentiment of distrust and they are most likely going to be turfed at the next election so they have given themselves a potential six month pay bonus. By rights, the incoming council members should pursue a clawback of this outrageous misuse of power of the exiting members citing the retroactive clause implemented by this group of glutenous pigs at the public trough.
If the answer to the second question is anything other than “members or close friends and family of council” then the committee should foot the bill on their own.
Fat chance that will happen. The extra $431,602 this package will cost the taxpayers will come from programs that are underfunded as it is or an increase in our taxes. (Not to mention the $1,000,000 the current plan will cost us.)
This same council cannot find the money for a hospital, yet they ignored that to the peril of their constituents in favour of padding their own pay when they lose their job. Funny thing, if the council members did their jobs well they probably wouldn’t be removed from office come election. If they don’t do their jobs well, why should they profit for incompetence? In the real world, the best you can usually hope for is one week for every year of service. How is it these people feel they are worth four times that?


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Keywords : Port Site Infections
A Study On Port Site Infections After Laproscopic Cholecystectomy At A Tertiary Care Centre Of Bihar
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 3, Pages 2912-2917
Introduction: Laparoscopic cholecystectomy is the gold standard treatment for
symptomatic gallstones. Generally, most of the surgical procedures may end with
complications. One of these complications is surgical site infection (SSI).
Materials and Methods: A descriptive study on 250 Patients was conducted by the
Department of General Surgery of Narayan Medical College & Hospital, Jamuhar,
Bihar. The study duration Was from March 2019 to February 2020. Ethical permission
was obtained from the Institutional Ethics Committee and informed written consent
forms were obtained from each patient before participation. All the patients were given
broad spectrum antibiotics (Ceftriaxone vial 1 g twice daily by intravenous infusion) at
the of induction of an aesthesia, in addition with Metronidazole 500 mg three times
daily intravenously for 24 hours postoperatively, and for period of five days for those
with acute cholecystitis. All data were collected in preformed format and statistical
analysis was done.
Results: The age range of the study participants was 24 to 67 years with a mean age of
44.6 years. Majority (221/250, 88.4%) of the patients were female. Spillage of bile,
stones or pus is an important predictor of infection, such incidence was reported with 19
(7.6%) cases. Port site infection (PSI) was reported in 9 patients, which constituted
3.6% of the study population. Out of these cases, 2 (22.2%) cases were deep seated and
rests were superficial infection.
Conclusion: Special consideration should be taken in chronic deep surgical site
infection. Most of the PSIs are superficial and more common in males.


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Healthy Blood Pressure BPS-5 is the exceptional complement that helps to manipulate the blood stress stage with much less effort, time and money.
Product Name: Healthy Blood Pressure BPS – 5
Official Website: CLICK HERE
Healthy Blood Pressure BPS – 5 Review
BPS 5 is the all herbal and special answer designed by using Dr. Dan Ritchie, a heart attack specialist. It can assist to manage your blood strain and keep away from all foremost blood stress associated issues. It can decrease your stress, nervousness and melancholy levels, which are the key elements in contributing to excessive blood stress or hypertension. It can additionally assist to manipulate your blood stress safely and overcome hypertension at domestic with little or no effort.
As the body gets older, the threat of many health concerns at once can be overwhelming. Some people may be concerned about the wrinkles that are developing near their eyes and mouth, while others grow concerned that their mind isn’t what it used to be. However, heart disease is one of the leading causes of death in the United States today, making it more important to take care of the heart and blood pressure.
Most humans locate excessive blood strain problems at a every year appointment with their health practitioner or land themselves in the emergency room. The coronary heart is powerful, however the solely way to maintain it wholesome is to control blood pressure. Some humans have to take medicinal drug to keep blood pressure, even though many physicians will additionally propose a more healthy diet low in cholesterol and sodium. Using BPS-5 can make a major difference throughout the body.
What is Healthy Blood Pressure BPS – 5
BPS 5 is an herbal supplement created in Canada that is designed to safely and naturally lower high blood pressure and improve your energy levels. It is known as “Dr. Dan Ritchie’s Healthy Heart System” and can be bought immediately on line besides a prescription. It is a special mixture of 5 natural ingredients. Of these, it includes caffeine, guarana, inexperienced tea extract, yerba mate, Cayenne, ashwagandha and more. Each ingredient has been personally chosen primarily based on the consequences they produce in research with actual people. It is endorsed to speak to your medical doctor earlier than beginning a new supplement, mainly if you have had a coronary heart assault or stroke.
What are the ingredients in Healthy Blood Pressure BPS – 5
High blood pressure can cause a number of serious health issues and even death. If it is left untreated or allowed to build up too much stress and damage then you may suffer a heart attack, a stroke or even kidney failure. Your body’s energy levels are inextricably linked with the proper functioning of the heart and other organs. When there is an imbalance in the levels of energy, the body cannot work as efficiently as it should and that can lead to all sorts of other problems including pain, depression, fatigue, anxiety and more. This is one of the main reasons why so many people are looking for ways to control their blood pressure safely and naturally.
The BPS 5 is now not solely advocated for these who are struggling from hypertension, however it additionally reduces stress and anxiety, which can expand the threat of coronary heart assault or stroke. It is in a position to decrease excessive blood stress by way of lowering stress and anxiety. It includes caffeine, a herbal stimulant that will increase your blood pressure, reduces your coronary heart fee and motives your coronary heart muscular tissues to relax. Guarana, a herb that is used for a range of scientific conditions, such as cancer, reduces depression, nervousness and stress and reduces the getting older results of stress and aging.
This is a brilliant way to manage your hypertension and stop future attacks. By taking BPS 5 tablets each and every day, it helps to manage your stress stages and decrease the anxiousness and despair that frequently accompany hypertension. Caffeine in this product is a herbal improve for your machine that permits you to hold healthful manipulate of your blood strain at all times. It reduces the anxiousness and melancholy that frequently accompany hypertension, which approves you to manage your blood stress greater effortlessly and effectively. Guarana is additionally fine at regulating your appetite, as well. If you have a difficult time controlling your appetite, this may additionally be simply what you want to lose weight and get in the best shape of your life.
Many humans use Guarana as an choice to prescription drugs, such as Celexa and Lexapro, due to its said aspect consequences and weight loss benefits. However, there have been no published studies comparing Guarana with other prescription medications and products. There is limited information available on its use for treating hypertension.
There are many Healthy Blood Pressure BPS 5 reviews online that can help you decide which product is right for you and your family. If you purchase BPS 5 and use it properly, there is a chance that you will not only find great blood pressure control, but other positive benefits as well.
BPS-5 consists of many advantages linked with decreasing blood strain ranges which may additionally consist of:
- Avoids aging results in more youthful bodies
- Lowers the threat of strokes, cardiovascular disease, excessive sugar degrees, and joint aches
- Supplies the most crucial nutrients for having actually enhanced power levels
- Supports an overall state of wellness and boosts the state of mind
- It helps the thought war depression, stress and anxiety, and additionally stress and anxiety.
- It does no longer create any facet consequences due to the fact it’s made simply with all-natural components.
- It assists to keep a healthy weight.
- It may additionally be top for reducing bad ldl cholesterol stages and preserving the heart-healthy.
- Both adult males and ladies can eat it besides any trouble.
- It can sustain the gastrointestinal system, cognitive feature and also might safeguard versus amnesia.
- It consists of the Healthy Blood Pressure Method as a bonus.
- It uses a 100% money-back guarantee, implying it’s a risk-free investment.
- Boosts the quality of life and also, hence, confidence.
- Bps-5 is the most effective service to take control of healthy and balanced blood pressure level and also decrease high blood pressure.
- It helps to decrease ldl cholesterol and decorate the coronary heart operating.
- The herbal energetic components lower the anxiousness and additionally makes you to loosen up by means of reducing Bp.
- It is the herbal remedy of hypertension and additionally consequently there is no bad negative results reported.
- There is no age-related problem being used the supplement. Also a 90-year-old man or woman can use it.
- It improves your metabolism and keeps a healthy and balanced weight.
- The complement sustains wholesome and balanced digestion, thinking running and additionally memory.
- You can clearly experience lots healthier, energised and additionally full of life physique by means of consuming this supplement.
- There is additionally one hundred percent cash lower back design that backs the item.
- You will additionally get a Healthy blood Pressure approach that assists to help you in managing the excessive blood pressure.
- The complement is supplied in on line in its reliable internet site only.
- Those that are beneath medication, Expectant as properly as breast-feeding female should reflect onconsideration on Doctor prior to ingesting this supplement.
As lengthy as you use the complement in accordance to the directions, you have to note a distinction in your readings. Many humans who used the product to manipulate their blood strain mentioned being in a position to reduce down on their fats consumption besides sacrificing any style or enjoyment of the meals they generally eat.
For most effect, purchase Healthy Blood Pressure BPS 5 from a reliable company. Make positive that the complement consists of the components listed above, as nicely as some different demonstrated ingredients. Don’t be fooled with the aid of small claims on the packaging or testimonials from a “brand.” If the employer does no longer listing the precise components in their supplements, appear somewhere else for a product that does.


Is Microsoft going on a shopping spree?
According to the Gartner Group analysts, the world's largest software group could soon take over several companies. This is justified by the fact that Microsoft is sitting around 38 billion US dollars, but nothing can do with it.
Vor Microsoft had to hold back, especially during the ongoing AntiTrust process, as the company was in danger of being split in two. But now there is fierce speculation about which path Microsoft will take. Since a large-scale purchase would still be too risky at the moment, there is speculation about possible dividends for the shareholders. Besides, with analysts believing that Microsoft will come out of the process largely unimpaired, something will have to be done with what is likely to be $ 40 billion in the next quarter. Microsoft has bought a total of 60 companies in the past 10 years, this time service and media groups are at the top of the wish list. If the study is to be believed, Microsoft will take over five large IT companies by the end of 2005, one of which is supposedly known worldwide. This would make it much easier to establish the .NET strategy on the market. In addition, you simply need more manpower to support the increasing number of large customers with a wide variety of services.


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With cougars growing in popularity and many young men opting for cougar dating, this hasn’t stopped the cougar myths from doing the rounds. One major truth about cougars is that they are independent and confident women , however the misconceptions are many. Some of the cougar dating myths debunked are as follows:-
A Cougar Preys on Innocent Younger Men
This is of course not true because there are many younger men naturally attracted to older women. Cougars are very desirable women with a lot of sexual appeal and other interesting traits. This is why younger men will definitely find them very appealing. Often times it is these very young men who go after these older women because they consider them worthy conquests. This is very unlike the widespread belief that the woman is the predator.
The Younger Man Will Cheat on Her with a Younger Woman
Unless the younger man is naturally a cheater, the misconception that he will find someone his age and date them behind the cougar’s back is wrong. The relationship between a cougar and her younger man can be fulfilling and genuine for both of them with no lies and secrets. In fact with her confident and young-spirited nature, the cougar is totally compatible with the young man since they are both getting what they seek in that kind of relationship.
The Older Woman Will Lose Interest
They might not have a lot of things in common but to base a relationship’s survival on that is totally wrong. The older woman and the younger man definitely have the same interests in the relationship and when they both play their part, the relationship can last for a very long time. She might be an older woman, independent and probably headstrong; she will not just lose interest and walk away without reason. She is not a brat but an older and mature woman who knows what she wants out of a relationship and will therefore work towards making it a success.
A Younger Man Will Want Children Someday And Dump Her For A Younger Child-Bearing One
The child issue is one that any couple would face. Having children isn’t the most important thing for all young men. If a young man loves this older woman who is special to him, then he might to choose to simply be with her for the rest of his life. She is capable of fulfilling him in many other ways and besides, many younger men go for these older women to avoid the pressure of marriage and children that most younger women subject them to.
They Won’t Fit into Each Other’s Social Lives
Yes there might be some negative reactions and strong opposition from the people in both their lives, but this will mostly happen when the relationship is new. People will in the end simply get used to seeing them together just like any other relationship. The couple that is dating openly will often times be ready to deal with all sorts of reactions from people close to them such as friends and family. Acceptance comes in the end.
Younger Men Who Date Cougars Are Weird
This is not true; the younger men who date older women are no different from their other counterparts who date women their own age. They just love the adventure and the difference that comes with dating an older woman. In fact they might be special in a good way because they have the courage to go after this secure, independent and probably intimidating woman. This is courage that many definitely lack.
There are more cougar dating myths but the above ones are the most common. What is not a myth is the spread of the cougar dating phenomenon across the world. I was shocked the other day looking through Google, to see how far cougar dating has advanced! Even our Aussie Sheilas have got cougar dating web sites!
UK guys are rocking with cougars AND grannies! Can you believe this? Granny dating, GILF dating and MILF dating are very hot in the UK right now and have been for many years. Even wiki has no entry for granny dating! It seems that young UK guys go for seriously older women and why not I say, as older women have much more experience than younger women, are easier to please and won’t whine about not going out to dinner or a disco. Older women want to get it on. Why is this? Women are taking care of themselves much more as they get older. They eat right and keep fit and as a result they look good! One of the hottest granny dating sites in the UK is www.hotgrannydating.co.uk – hey the site might not be the most up to date, but it has thousands of members and a very loyal membership. If you are one of my UK boys or girls, check that site out. It rocks!


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When the weather starts to get colder (and usually wetter in the UK) it’s easy to retreat to the sofa and TV and snuggle up. But there is plenty to enjoy in the great outdoors at this time of year.
In fact, if you have children it’s even more important to ensure you’re getting out and about at this time of year, as outdoor play at any time of the year facilitates healthy brain development in youngsters.
An article for Business Insider recently pointed to a scientific study that has proven the positive benefits of outdoor play. However, the news provider also cited a survey by the National Trust, which found children aged 10 to 16 spend fewer than 15 minutes a day taking part in “vigorous outdoor activity”.
Dr Robert Murray, pediatrician, author and board member of Action for Healthy Kids, told the news provider that there’s no reason to spend more time indoors in the winter. He stressed that it’s the perception of inconvenience that tends to make more families stay home at this time of year.
“With well-insulated caps, mittens, gloves, socks and appropriate layers, kids can get outdoors too and enjoy some fresh air,” he said.
If you’re struggling to break the habit of screen time, try taking yourselves out of your home environment. Stock up on winter caravan supplies in the UK and head off for a couple of nights somewhere beautiful.
Dr Murray also suggested using the likes of mobile phones and tablets to help you and your kids research fun outdoor activities and places to visit, so that you can enjoy the best of both worlds.
The Guardian recently suggested some top small towns in the UK for a winter break. Among them is Bakewell in Derbyshire, that has the added advantage of being on the edge of the Peak District, as well as Holt in Norfolk which is well placed to allow you to discover some of the area’s stunning beaches without the summer crowds.


The beginning of the 2020-21 high school season has not exactly gone as the Solon Comets girls basketball team had planned. Aside from having to combat constant schedule upheavals due to the pandemic the team opened its season on a five-game losing streak.
The Comets graduated three senior starters last year and have several new faces that are learning how to play together. Solon had been competitive in most of its games but couldn’t get over the hump. The Comets put an end to their five-game skid on Jan. 16 with a decisive 67-37 victory over Greater Cleveland Conference rival Euclid Panthers last Saturday afternoon.
“They were excited but who wants to be 1-5? It’s nice to finally get the monkey off our back but at the same time the games that we lost I feel like we could have won a few of those games. I think that’s where the kids are still a little bit frustrated but if we can try and put a couple of wins together and I think our kids will be even more excited,” said Solon head coach Trish Kruse.
The Comets’ starting lineups have consisted of just one senior. Overall Solon has just three seniors on the roster this season. The team made a tweak to is starting lineup this past Saturday. Rather than start three sophomores, one freshman and a senior the Comets rolled out three freshman, one sophomore and one senior against Euclid.
For the first time in a while the team’s primary players are mostly underclassmen. Any team with fresh faces is expected to undergo some growing pains especially in a season that has been drastically altered. Still coach Kruse is not one to make excuses and knows that her team’s start to the season has not been good enough.
“Other teams have had delays too. We tell the kids no excuses,” she said, “We have got to figure it out. It was nice to get a win yesterday.”
The team may have figured something out. The Comets strung together one of their most complete performances of the season against the Panthers. They raced out to an early 14-8 lead in the first quarter.
The defense was locked in as Solon limited Euclid to eight points again in the second quarter. The Comets kept their hands active and posted a whopping 28 steals to collect 39 points off of 38 turnovers.
The offense was moving the ball around and good things always happen when the team shares the rock. The Comets held a commanding 35-16 lead at halftime. Solon finished the game with 11 assists on 26 made baskets.
“I guess we did a better job of rebounding than we had in the past five games. We held them to single digits, did a better job of getting the outlet passes, getting the ball up the floor, attacking the basket and not settling for the three-point shot,” said coach Kruse.
One of Solon’s biggest weaknesses this season has been settling for far too many jump shots. The team has capable shooters but there hasn’t been enough consistency in that area. The Comets made a concerted effort to attack the basket as they scored 40 points in the paint to earn their first conference win of the season.
“It was good. We got off to a nice start, played some good defense we rebounded, shared the basketball up the court,” coach Kruse said, “Overall it was a good game. Still maybe a little bit too many turnovers but overall it was better than what we played so I’ll take it and it’s a win.”
Coach Kruse was hopeful that the Comets could use this victory as a stepping-stone to right the ship. Unfortunately, Solon dropped a contest to Newark on Monday night.
As crazy as the season has been it doesn’t change the fact that the annual sectional tournament is nearing. Solon has made deep runs in the postseason the last three years and wants to continue that trend.
Senior guard/forward Hailey Weaver led Solon with 21 points, five rebounds, three assists and six steals followed by sophomore guard Cheyenne Hatcher with 14 points, six rebounds, one assist and five steals. Euclid’s leading scorer was Alexis Reese as she tallied 15 points, nine rebounds, two assists and one steal with Erin Miller scoring 12 points, four rebounds and two steals.


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Ever a dazzling and surprising upstart in the UK scene, Lone once again slaps his multicoloured hand across your chops with a loose and funky take on the wonkier side of house music. Wigflex is certainly the right label to be dropping this kind of track, being particularly adept at knowing a cheeky dose of silly but slick party fodder when they hear it. The beats bump hard on this tune, but really it's the loping lead melody that makes this the kind of jam that will stop the dance in its tracks and cause mass-hysterical body popping.
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Ravens to keep Jim Caldwell as offensive coordinator next season
Baltimore Ravens head coach John Harbaugh announced during a Monday press conference that Jim Caldwell will stay on as the team's offensive coordinator next season and that the team has hired former Eagles defensive coordinator Juan Castillo.
Caldwell, the former Indianapolis Colts coach, took over the offensive play calling after previous coordinator Cam Cameron was fired in December. He has helped guide the team to Super Bowl XLVII where they will face the San Francisco 49ers. Baltimore quarterback Joe Flacco has thrown for 853 yards with eight touchdowns and no interceptions in the Ravens' playoff run.


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How old is Phoebe Adele Gates? Is she Dating? All Details here
Know who Phoebe Adele Gates is? Is she single? And details concerning her personal life are here in this article.
Phoebe Adele Gates is one of the well-known star children who has been in the public eye since she was born due to the enormous success that her father, Bill Gates, has achieved. Since Phoebe is the daughter of one of the wealthiest men in the world, it is not surprising that she had a comfortable upbringing. But in addition to that, Mr. Gates imposed several stringent guidelines on his kids. Phoebe, who is just stunning, came into the world on September 14th, 2002, in Seattle, Washington.
Melinda Gates, Phoebe's mother, is one of the many influential philanthropists working worldwide. Phoebe has an identity as a highly educated person with a Stanford University degree. This is in addition to all the exposure that comes with being the daughter of one of the world's richest men. Phoebe was raised alongside her two elder siblings, Rory John Gates, born on the 23rd of March 1999, and Jennifer Katharine Gates, born on the 26th of April 1996. Phoebe's family is considered one of the world's wealthiest families.
In addition, people are curious about Phoebe Adele Gates' partner and her love life, which is one of the other things that are drawing a lot of interest. In the next article, we will investigate her biography in great detail, including topics such as her education, net worth, and a variety of other little-known information. This article is focused on her love life and relationship details. Let's get started.
Is Phoebe Adele Gates Single? Her Relationship Details
The 20-year-old lady and her boyfriend, Chaz Flynn, have been together for more than a couple of years and have a wonderful connection. Phoebe's past Instagram pictures made it evident that they have been together since mid-2019, even though the couple had never revealed when they started dating. In August 2019, the cute couple was observed having a good time on a boat ride in Hood Canal with a few of their close pals.
Image: Phoebe Adele Gates with her boyfriend, Chaz Flynn
She sends images to her boyfriend regularly, and they exchange them for various reasons. On July 8, 2020, she shared a selfie on social media showing herself and her boyfriend enjoying her boyfriend's birthday. Phoebe wished her love a "happy birthday" and typed it in the photo caption.
You May Also Like to Know: Who is Dannielynn Birkhead's Father? Learn about her Family here!
It would appear that the two are enjoying their time together as a couple. In addition, Phoebe's boyfriend, Chaz, is currently attending the University of San Diego and plans to earn his degree there in 2025. For some reason, Phoebe has deleted the pictures of them enjoying themselves together but fears not any information related to them being separated is not out, and we can say that they are still in the growing phase, so maybe they want to stay low regarding their relationship and make it private rather than public.
Phoebe Adele Gates And Her Siblings Followed Rules at Home
Even though their father was one of the most influential figures in the history of technology, they were expected to abide by the family norms. The children of Bill Gates did not get their very first cell phones until they were 14 years old. When they first started using phones, they were strictly forbidden from bringing them to bed with them and using them while eating. Additionally, they were not permitted to use their phones at the dining table.
Image: Phoebe Adele Gates with her dad, Bill Gates
Source: Instagram @pheebeegates
In 2017, Gates stated in an interview with the Mirror, "We don't have cell phones at the table when we are having a meal. We didn't give our kids cell phones until they were 14, and they complained because other kids received them sooner."
Don't miss: Who Is Rebel Wilson's New Girlfriend, Ramona Agruma?
For more news and information related to your favorite celebrity, stay connected to Glamour Fame.

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Iraq Under Siege:
The Deadly Impact of Sanctions and War
Edited by Anthony Arnove
South End Press, 2000, pp 216
“Iraq Under Siege” is a wide-ranging collection of personal essays, first-hand accounts and analyses of the effect of the war and sanctions on Iraq, raising its many voices to rail against the U.S. policy that many feel has reached near-genocidal proportions.
This collection, not the first of its kind (see “The Children are Dying,”1996; and “Metal of Dishonor,” 1997), is perhaps the most comprehensive documentation of the ongoing suffering of the people of Iraq. The latest book by South End Press brings together such well-known sanctions critics as Howard Zinn, Noam Chomsky, Denis Halliday, Phyllis Bennis, Robert Fisk, Rania Masri, Kathy Kelly and John Pilger, as well as many others.
An excellent source book for background material on this subject, and as useful for an academic as for an activist, “Iraq Under Siege” is well-organized and well documented. Although it certainly does not condone the brutality of Saddam Hussein, it makes it clear that the overwhelming destruction of the society is now largely due to the economic embargo, enforced by the U.S. The issue of the effects of depleted uranium, which was used in southern Iraq in 1991, is also dealt with.
“Iraq Under Siege” would make an ideal text for college courses in Middle East studies, political science, or even contemporary ethics classes. The book is also geared to generating activists and encourages a stronger movement to end the sanctions.
This review appeared in Al Jadid (Vol.6, no. 31, Spring 2000)
Copyright (c) 2000 by Al Jadid

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- Please check and comment entries here.
Intracellular calcium (Ca2+) concentration ([Ca2+]i) is a key determinant of cell fate and is implicated in carcinogenesis. Membrane ion channels are structures through which ions enter or exit the cell, depending on the driving forces. The opening of transient receptor potential vanilloid 1 (TRPV1) ligand-gated ion channels facilitates transmembrane Ca2+ and Na+ entry, which modifies the delicate balance between apoptotic and proliferative signaling pathways. Proliferation is upregulated through two mechanisms: (1) ATP binding to the G-protein-coupled receptor P2Y2, commencing a kinase signaling cascade that activates the serine-threonine kinase Akt, and (2) the transactivation of the epidermal growth factor receptor (EGFR), leading to a series of protein signals that activate the extracellular signal-regulated kinases (ERK) 1/2. The TRPV1-apoptosis pathway involves Ca2+ influx and efflux between the cytosol, mitochondria, and endoplasmic reticulum (ER), the release of apoptosis-inducing factor (AIF) and cytochrome c from the mitochondria, caspase activation, and DNA fragmentation and condensation. While proliferative mechanisms are typically upregulated in cancerous tissues, shifting the balance to favor apoptosis could support anti-cancer therapies. TRPV1, through [Ca2+]i signaling, influences cancer cell fate; therefore, the modulation of the TRPV1-enforced proliferation–apoptosis balance is a promising avenue in developing anti-cancer therapies and overcoming cancer drug resistance.
1. [Ca2+]i and the Critical Balance between Apoptosis and Proliferation
Molecular mechanisms that mediate cell death and proliferation exist in balance in functional physiological systems. Proliferation is involved in structural development and renewal, while programmed cell death is necessary to eliminate defective cells and prevent uncontrolled growth. Carcinogenesis results from imbalances in the described pathways, which favor proliferation and reduce apoptosis . Therefore, anti-cancer therapies shift the balance in the opposite direction by reducing proliferation and upregulating apoptosis.
Apoptosis is defined as programmed cell death, characterized by fragmentation of inter-nucleosomal DNA . Two major mechanisms of apoptosis are an extrinsic, death-receptor mediated mechanism, and an intrinsic, mitochondria-mediated mechanism . The extrinsic mechanism involves the linking of membrane death receptors to adapter proteins, which bind and position pro-caspase 8 for conversion into caspase 8; the intrinsic mechanism is triggered by the release of cytochrome c from mitochondria, which promotes caspase 9 activation . The Bcl-2 family of proteins, which includes the proapoptotic proteins Bax and Bak and the antiapoptotic protein Bcl-2, is implicated in the intrinsic mechanism of apoptosis . Both the intrinsic and extrinsic apoptotic mechanisms lead to the activation of caspase 3, which mediates apoptosis through nuclear activity.
Calcium (Ca2+) is a second messenger that influences the proliferation–apoptosis balance. Intracellular Ca2+ ([Ca2+]i) is modulated by receptor-operated, store-operated (SOC), and voltage-sensitive ion channels, ion exchangers, pumps, Ca2+ binding proteins, mitochondrial Ca2+ ([Ca2+]m), and endoplasmic reticulum (ER) and sarcoplasmic reticulum (SR) Ca2+ ([Ca2+]ER and [Ca2+]SR) . Intracellular Ca2+ release channels comprise one subset of ion channels; these include the ryanodine receptor (RyR) and inositol 1,4,5-triphosphosphate (IP3) receptor (IP3R) channels, both of which are localized to the ER and SR. RyR channels, which are activated by elevated [Ca2+]i or protein signaling, and IP3R channels, which are activated by IP3 binding, release Ca2+ from the ER and SR. Through [Ca2+]i signaling, these two channel types modulate muscle contraction and nerve impulse transmission . Abberant Ca2+ transport from the ER or SR to the cytosol may elevate [Ca2+]m and consequently induce mitochondrial dysfunction .
Beyond locomotion and neurotransmission, shifts in [Ca2+]i homeostasis may also mediate cell death or proliferation. For instance, while [Ca2+]i signaling via IP3R contributes to proliferation and oncogenesis, RyR [Ca2+]i signaling supports apoptosis in lung cancer cells . Furthermore, Ca2+ influx through T-type voltage-gated Ca2+ channels (VGCC) is implicated in the proliferation of cancerous and noncancerous cells, while the blockage of such channels promotes apoptosis in glioblastoma cells . In contrast, Ca2+ influx through L-type VGCC causes death in bovine chromaffin cells . Notably, [Ca2+]i-mediated cell death may be apoptotic or necrotic in nature, depending on the time of exposure and [Ca2+] i involved .
Significantly, [Ca2+]I signaling regulates proliferation, invasion, and metastasis in cancerous tissues . A variety of oncologic therapies, including cisplatin, arsenic trioxide, trimethyltin chloride, and some candidate epigenetic drugs, induce their proapoptotic and anti-proliferative effects (in part or in whole) through the modulation of [Ca2+]i . Therefore, specific [Ca2+]i-affecting proteins, including transmembrane ion channels, which mediate Ca2+ flow between the extracellular space and the cytosol, are potential targets for chemotherapeutic agents.
Transient receptor potential (TRP) channels comprise a large family of membrane Ca2+ channels, which respond to a wide variety of environmental stimuli . Transient receptor potential vanilloid 1, or vanilloid receptor 1 (TRPV1/VR1), known as the capsaicin receptor, is a member of the TRPV subfamily of TRP channels. TRPV1 is a ligand-gated ion channel which is activated by capsaicin and capsaicin analogues (e.g., resiniferatoxin, RTX), heat, and endogenous cannabinoids such as anandamide (AEA); its antagonists include capsazepine and ruthenium red . The stimulation of TRPV1 causes Ca2+ and Na+ influx through transmembrane ion channels. While these channels generally exhibit selectivity for Ca2+ over Na+, the precise nature of this selectivity depends on a variety of factors, including the nature and concentration of the agonist . TRPV1 is involved in thermoregulation, circadian rhythms, energy intake and metabolism, and acute, chronic, and inflammatory nociception; as such, the ion channel receptor is a target in the development of analgesic therapies . Furthermore, given its role in modulating [Ca2+]i, TRPV1 influences the balance between proliferation and apoptosis .
2. Balance Between Apoptosis and Proliferation Mediated by TRPV1
The activation of the TRPV1 ion channel is a critical signal involved in numerous intracellular processes, some of which trigger either apoptosis or proliferation (Figure 1). While the apoptotic effects of TRPV1 are well characterized, literature on TRPV1-related proliferation remains sparse. The binding of exogenous agonists to the TRPV1 receptor and subsequent Ca2+ influx from the cytosol into the cell are characteristics shared between the apoptotic and proliferative pathways. However, both the positive allosteric modulation of cell membrane TRPV1 receptors and the activation of endoplasmic reticulum (ER)-localized TRPV1 channels are associated exclusively with the pro-apoptotic pathway .
Figure 1. Activation of the TRPV1 ligand-gated ion channel causes Ca2+ influx into the cytosol and influences the balance between proliferation and apoptosis. Apoptotic signaling occurs through the cytosol, mitochondria, ER, and the nucleus. In contrast, the proliferative effects of TRPV1 are mediated by the activation of other cell membrane receptors, ER signaling, and cytosolic protein signaling cascades. The proliferative, proapoptotic mitochondrial, proapoptotic ER, and proapoptotic nuclear signaling mechanisms are highlighted in the colored boxes, and specified in Figure 2 Figure 3 Figure 4 Figure 5, respectively.
Figure 2. TRPV1 induces proliferation through Ca2+ entry, ATP release and membrane P2Y purinoceptor 2 (P2Y2) activation, and the transactivation of epidermal growth factor receptor (EGFR). Elevated [Ca2+]i and ATP-P2Y2 binding upregulate intracellular inositol triphosphate (IP3) via phospholipase C (PLC); IP3 opens store-operated channels (SOC) and thereby causes Ca2+ release from the ER. Activated P2Y2 receptors also begin the phosphoinositide-3-kinase (PI3K)/Akt pathway, a kinase signaling cascade that ultimately activates Akt. TRPV1 additionally transactivates EGFR; this prompts Ras/Raf/MAPK-ERK kinase (MEK)/extracellular signal-regulated kinase (ERK) signaling, which upregulates ERK 1/2 mitogen-activated protein kinases (MAPK). Akt and ERK 1/2 MAPK promote proliferation through nuclear activity.
Figure 3. TRPV1 induces mitochondrial dysfunction through Ca2+ and Na+ entry, membrane depolarization, reactive oxygen species (ROS) production, and the release of cytochrome c and apoptosis-inducing factor (AIF). Initial Ca2+ and Na+ influx causes the hyperpolarization of the mitochondrial membrane, while consequent Ca2+ export through the permeability transition pore (PTP) and active Ca2+ removal via the Na+/Ca2+ exchanger (NCLX) depolarize the membrane. As inputs, downregulated intracellular glutathione ([GSH]i) and upregulated Bax arise from nuclear activity. Upon their release (driven by membrane depolarization), AIF translocates directly to the nucleus, cytochrome c participates in intracellular caspase 9 activation, and intracellular ROS (ROSi) supports the activation of p38 MAPKs.
Figure 4. Cell membrane and ER TRPV1 activation promote ER stress through the modulation of [Ca2+]ER, activation of various kinases, the upregulation of nuclear transcription factors, and the release of c-Jun N-terminal kinase (JNK) into the cytosol. TRPV1 proteins localized to the ER membrane contribute only to protein signaling within the ER, while TRPV1 channels in the cell membrane promote both [Ca2+]i and protein signaling. Initial Ca2+ entry into the ER occurs through the sarco/endoplasmic reticulum Ca2+ ATPase 2 (SERCA2) pump, which is eventually blocked, causing net Ca2+ export via the ryanodine receptor 2 (RyR2) channels. Glucose regulated protein 78 (GRP78) upregulation and Bcl-2 downregulation, as inputs, arise from nuclear activity. MAPK is both an input and output of ER stress, as it is upregulated via both mitochondrial activity and JNK. Activating transcription factors 4 (ATF4) and 6 (ATF6) and X-box binding protein 1 (XBP1) are transcription factors that constitute the downstream nuclear targets of ER stress; ATF4, in particular, feeds back to the ER by upregulating GRP78.
Figure 5. Pro-apoptotic processes induced by TRPV1 localized in the nucleus. The nuclear component of ER stress occurs as ATF4, ATF6, and XBP1 are activated by ER stress and upregulate GADD153, which in turn downregulates Bcl-2 protein production. The upregulation of GRP78 by ATF4 feeds back to and enhances ER stress. The cytosolic activation of the ATM serine-threonine kinase by TRPV1 protein signaling and calcineurin by elevated [Ca2+]i promote the nuclear transcription factors E2F1, MYC, and NFAT2, which upregulate p53. The precise mechanism through which TRPV1 activates ATM remains unclear. p53 upregulates the apoptotic mediators Bax, p16, and p21, which activate caspase 9 and 3. Activated caspases translocate from the cytosol to the nucleus, where they mediate DNA fragmentation and condensation.
Abbreviations: ATP, Adenosine TriPhosphate; AIF, Apoptosis Inducing Factor; Akt, Akt serine-threonine protein kinase; ASK1, Apoptosis Signal-regulating Kinase 1; ATF4, Activating Transcription Factor 4; ATF6, Activating Transcription Factor 6; ATM, ATM serine-threonine kinase; Bax, Bcl-2 associated x protein; Bcl-2, B-cell lymphoma 2; BID, BH3 Interacting-domain Death agonist; E2F1, E2F transcription factor 1; EGFR, Epidermal Growth Factor Receptor; eIF2, eukaryotic Initiation Factor 2; ERK, Extracellular signal-Regulated Kinase; GADD153, DNA Damage-Inducible Transcript 3; GRP78, Glucose Regulated Protein 78; [GSH]i, intracellular glutathione; [GSH]m, mitochondrial glutathione; IP3, Inositol triPhosphate; IRE1, Inositol-Requiring Enzyme 1; JNK, c-Jun N-terminal Kinase; MAPK, Mitogen Activated Protein Kinase; MCU, Mitochondrial Ca2+ Uniporter; MEK, MAPK-ERK Kinase; MMP, Mitochondrial Membrane Potential; MYC, Myc proto-oncogene; NCLX, Na+/Ca2+ exchanger; NFAT2, Nuclear Factor of Activated T-cells 2; P2Y2, P2Y purinoceptor 2; PDK, Phosphoinositide-Dependent Kinase; PERK, PKR-like Endoplasmic Reticulum Kinase; PI3K, PhosphoInositide-3-Kinase; PKC, Protein Kinase C; PLC, PhosphoLipase C; PTP, Permeability Transition Pore; Raf, Rapidly accelerated fibrosarcoma; Ras, Rat sarcoma; ROS, Reactive Oxygen Species; ROSi, intracellular Reactive Oxygen Species; ROSm, mitochondrial Reactive Oxygen Species; RyR2, Ryanodine Receptor 2; SERCA, Sarco/Endoplasmic Reticulum Ca2+ ATPase; SOC, Store-Operated Channel; Src, proto-oncogene tyrosine-protein kinase Src; TRPV1, Transient Receptor Potential Vanilloid 1; VDAC, Voltage Dependent Anion Channel; XBP1, X-box Binding Protein 1.
This entry is adapted from 10.3390/ijms21114177
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Germinoma tumorTumors of the germ cells can be categorized into five forms:
- Endodermal sinus tumor
- Embryonal carcinoma and
Cells responsible for the occurrence of germinoma grow in the pineal region, mainly affecting the medial structures of the CNS (Central Nervous System), in the second decade of life, prevalent in males. Germinoma was named this way after discovering the overlapping with the testicular seminomas. Histopathologically, there is a uniform composition of germ cells and cytoplasm rich in glycogen.
Also in the group with germ cell tumors, teratomas are also covered.
Symptoms of intracranial tumors depend on age, tumor location and its nature. Symptoms can be divided into two groups:
– Symptoms of increased intracranial pressure;
– Symptoms of brain lesion, either by tumor or by the associated cerebral edema.
The tendency of tracking it can lead to early and frequent occurrence of obstruction of circulation system. This makes the initial symptoms in the majority of intracranial tumors in children to be more like signs of ICH rather than neurological disorders.
Symptoms of increased intracranial pressure
They have been widely discussed in the ICH syndrome.
The headache may be the only clinical manifestation of the syndrome of ICH, which in fact is often misinterpreted as intestinal parasites, refractive disorders, somatic disorders, migraine, oto-mastoiditis, and sinusitis. The characteristics of headache which are its improvement after vomiting after it had already reached its maximum intensity. Sometimes headache occurs when the patient enters the standing position and can be remitted in other positions or when the patient flexes its head. This type of headache occurs in the posterior cranial fossa tumors. Headache may occur in emergencies, which lasts several minutes.
Vomiting occurs in 70-80% of cases, regardless of the location and type of tumor. Vomiting may be associated with abdominal pain and thus simulate an abdominal condition as appendicitis, etc. As they cause dehydration, vomiting can lead to temporary relief of the syndrome of ICH. Vomiting constitutes the onset of clinical sign of intracranial tumors. Nausea may accompany vomiting, but these are found in 20% of cases.
Papillary edema, as a manifestation of ICH is rarely found at extreme ages.
The mortality rate after 5 years is relatively high, between 70 and 90 percent. The cause of this disorder in not yet known. As in almost all cases of tumors, the treatment options are the same: radiation intake, surgery and chemotherapy.
|flu, germinoma, headache, ich, intracranial, symptoms, syndrome, tumor, tumors, vomiting|


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In his new music video for ‘So Long’, which features country songstress Cam, Diplo continues his foray into country culture as he plays the Stagecoach Festival 2019.
The music video for ‘So Long' sees a montage of the DJ’s shows at the country music festival. The video also include footage of Diplo partying with celebrity chef Guy Fieri and hanging out with Billy Ray Cyrus and Lil Nas X. This come after the release of the latter two’s viral hit ‘Old Town Road’.
Check out Diplo’s music video for ‘So Long ft. Cam’ below:


LHC to hear CM Elahi's vote of confidence petition on Wednesday
PML-N directs MPAs of united opposition in PA to reach and stay at LHC till hearing
Stay tuned with 24 News HD Android App
The Lahore High Court (LHC) will hear an important case of the Punjab Chief Minister Chaudhry Pervaiz Elahi's vote of confidence tomorrow (Wednesday).
According to the 24News HD TV channel, the leadership of Pakistan Muslim League Nawaz (PML-N) has directed all the legislators of the united opposition in the Punjab Assembly to reach and stay at the LHC till the hearing of the case.
As per the advice of the party leadership, the Members of the Provincial Assembly of Punjab (MPAs) have been instructed by the leadership that they will join the Punjab Assembly session after attending the hearing in the LHC.


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Why is hip resurfacing recommended for younger, more active patients?
A recent response to a question regarding hip resurfacing highlighted differences between hip resurfacing and conventional Total Hip Replacement. While, as indicated, conventional THR remains the gold standard for most patients, the treatment of young, active patients with disabling hip arthritis remains challenging. A critical review of available literature suggests that this population, in general, may have results that are not as good as that of conventional hip replacement in older adults, with increased rates of loosening, as well as wear of prosthetic materials. Many suggest this is related to increased activity levels in these younger (less than 60 years old) patients. However, it is this population in which hip resurfacing may provide some promising results. Since the inception of hip-resurfacing procedures, advances in understanding metallurgy, as well as refinement of techniques and patient selection, have significantly improved outcomes. Analysis of results of hip resurfacing reveals that despite slightly increased rates of complications, the largest experience of metal-on-metal hip resurfacing – Birmingham Hip Resurfacing – has yielded 10-year results that have met, and in some cases (notably among young active male patients), exceeded the results of conventional hip replacement in this population. In most cases, the patients have maintained a significantly higher activity level than is traditionally recommended for patients with conventional THR.
– Don P. Sanders, M.D., South Bay Orthopaedic Specialists Medical Center, Torrance


If Earth 2.0 exists somewhere in the universe, the chances of discovering it should increase. It is thanks to the involvement of another nation in the search. China's ambitions for space exploration seem enormous and this is evidenced not only by the announcements coming from the propaganda, but also by actual actions. The rover there explores the now invisible side of the Moon, as does Zhurong, who explores the surface of Mars. On the other hand, the Tiangong station orbits the Earth, which is supposed to compete with the International Space Station.
The Chinese holders of the world's largest radio telescope "FAST"
Chinese aspirations for cosmic domination
Taking the next step seems to be the natural course of things, and it will be about starting the search for our planet's twin. Earth 2.0, as it is called, is to exist somewhere outside the solar system, but in our galaxy, the Milky Way. The key feature in favor of objects that will meet the requirements seems to be their orbit around their stars in the so-called residential zones. These types of areas have temperatures that are high enough to keep the water from freezing, yet low enough to prevent evaporation.
NASA recently boasted about crossing the five thousand identified exoplanets, or extrasolar planets, orbiting stars other than the sun. Despite such a large group of potential candidates for a second Earth, none of them seems to meet all the requirements. This is why the Chinese Space Agency (CNSA) intends to break the deadlock and accentuate its participation in the space race. Her new project will be funded by the Chinese Academy of Sciences and is so far in the early stages of implementation. In June, experts are to evaluate the preparations - if their opinion turns out to be positive, the construction of a satellite will be started, which will be launched on board the Long March rocket by 2026.
Earth 2.0, or how to find Earth's twin
Earth 2.0 will have seven telescopes on board, six of which will study the constellation Cygnus and the constellation Lutes. In total, the study will cover up to 1.2 million stars extending over an area of the sky almost 5 times wider than that observed by the Kepler Space Telescope. As if that were not enough, Earth 2.0 will also take into account the less visible and distant stars from Earth than in the case of NASA's TESS (Transiting Exoplanet Survey Satellite) telescope.
Jian Ge, who directs the Earth 2.0 mission, argues that the telescope designed within its framework may be even ten or fifteen times more powerful than the aforementioned Kepler telescope. The six instruments that make up it will use the transit method for observations, which is based on the detection of dips in the brightness of stars due to objects such as exoplanets passing in front of them. The seventh one will use a slightly different approach, known as gravitational microlensing. The Chinese satellite will observe a particularly star-rich area of the Milky Way for four years, focusing on extrasolar planets with earth-like orbits. Ge adds that the project will be an opportunity to strengthen international ties in the field of space cooperation.


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Ancient Double Stranded Turquoise Beads with Shell Beads and Carved Shell Pendant
Turquoise, Shell, Pearl, Silver
The necklace is 20 inches (51 cm) in length. The necklace weighs 26.4 gm.
A double strand of turquoise disc beads with a pendant made from shell. There are fourteen single drilled shell beads and six double drilled. There are eight round shell beads, two tabular shell beads and two tooth-like pendant beads. Opposite those pendants are two small tabular beads, one of which is of mother of pearl. The central pendant is 3.6 cm in width, 3.35 cm in height and 6.5 mm in thickness. The shell is slightly convex being 4.5 mm in actual thickness at the top and 3 mm in thickness at the bottom. The flat double drilled beads are 7 mm in length,1 cm in height, and 3 mm in thickness. The round beads are 6 mm in diameter. The tabular beads at the back are 8.4 mm in length, 9 mm in width and 3 mm in thickness. The small tooth pendants are also made from pieces of shell that 3mm in thickness and drilled through so that this becomes their length, the width being 6 mm and the height is 1 cm. The turquoise disc beads are 2 mm in length and 3.5 mm in diameter. All the beads except the large pendant are over two thousand years old. The double drilled beads and the small tooth pendants are Bronze Age and this dates to 2,000 B.C.E. making them four thousand years old. The turquoise beads are probably from this period as well. The round beads may well be Bronze Age but since round beads were made in all periods, there is nothing distinctive to use for dating purposes. We must rely on the context, and these beads did all come from the same source. The shell pendant at the center is certainly very old but probably not as old as the other beads. This design is not found with Bronze Age beads and is consistent with medieval Islamic designs. The type of shell used is found in headpieces from Afghanistan that are said to be Kazak. These old shell beads are ovals and square shapes without the scrolled edges found in this pendant. They all have very smooth worn surfaces that are the result of having been used and worn for generations.