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Child Guidance in Inter-War Britain: building ‘integrated personalities capable of taking their place as members of the family of the Church and of the State'(1)
The Child Guidance Movement took off in the United States in the immediate aftermath of the First World War and then, thanks in large part to American philanthropy, spread shortly afterwards to Great Britain and to Europe. The Movement sought to address emotional and psychological problems in children primarily through the use of psychiatric techniques and was thus, initially at least, part of a wider search for ‘mental hygiene’ in the inter-war period.
This paper explores this transfer from the United States to Great Britain, focussing on three particular, inter-related, issues. First, one of the clear aims of the movement in general was not only the treatment of ‘normal’ but emotionally and psychologically disturbed children, but also their observation for research purposes. Both of these were to take place in specifically designated clinics. Little thought appears to have been given, however, to the ethical dimensions of such observation. Child guidance was thus part of what medical sociologists such as David Armstrong have identified as the increasing surveillance of children in the twentieth century.
Second, the transfer of practice and philosophy from the United States was of itself problematic. It is clear that many British social workers sent to the United States for training in this field were greatly disturbed by the American emphasis on sexual matters. If this was true of social workers, it was even more so in respect of the general public and leading proponents of child guidance were at pains to deny its association with explorations of child – and indeed adult – sexuality. All this meant that British child guidance was on one level much less ‘scientific’ than its US counterpart, and indeed tended to fall back on moral categories of classification in respect of its patients.
Third, and related to the previous two points, other characteristics which can now be seen as raising ethical issues, but were again little commented upon at the time, impacted upon British child guidance and tended to separate it out from the American model. Most obviously, religion played a part, especially in Scotland where the first ‘proper’ child guidance clinic was also a Roman Catholic institution. This had quite explicit religious aims while simultaneously seeking to adopt a British variant of the medical/psychiatric model of child guidance. Such an approach clearly had significant ethical dimensions and overtones.
(1) Sister Jude (Maureen McAleer), Freedom to Grow: Sister Marie Hilda’s Vision of Child Guidance, (Glasgow, 1981), p.35.

domain: history


NanoCuvette™ One uses existing spectrophotometers and the SpectroWorks™ software to accurately measure refractive index, °Brix index and sucrose concentrations. Results are not affected by impurities and have a wide refractive index range.
Updated: 2023-08-11, author(s): CMLBY, EMIHO, ARPDE
Refractometers are a useful tool for measuring the sugar content of a solution using the °Brix index. However, their accuracy can be affected by the presence of air bubbles, particles, or other impurities in the sample. Refractometers typically also have a limited range, which may not be suitable for high sugar concentrations or samples containing other dissolved solids. Frequent calibration is also often required, which can be time-consuming. How to use other instrumentation?
NanoCuvette™ One uses existing spectrophotometers and the SpectroWorks™ software to accurately measure refractive index, °Brix index and sucrose concentrations. Results are not affected by impurities, have a wide refractive index range, and do not require calibration for precise measurements.
Sugar is a popular ingredient in various food and beverage products. The term "sugar" refers to sweet, soluble carbohydrates, including monosaccharides like glucose and fructose. Sucrose is the chemical name for the disaccharide made up of one glucose and one fructose unit. Different types of sugars can be extracted from the tissue of most plants and used commercially.
|Figure 1: The consumable NanoCuvette™ One required to complete measurements in a spectrophotometer together with analysis in the software SpectroWorks™.|
The measurement of refractive index is a well-established method for determining the sugar content in solutions. Therefore, refractometry is a widely used method in the sugar industry for quickly measuring the sugar content in solutions. For solutions containing a single, known compound, the refractive index measurement is a precise means of determining the concentration of that specific sugar. In the case of mixed solutions with a high sugar content, however, the refractive index measurement can only provide an approximate estimate of the sugar content due to the presence of interfering factors such as other dissolved substances or impurities. Nonetheless, refractive index remains a valuable tool for analyzing sugar content in various applications.
Traditionally, refractometers have been used as the tool to measure the sugar content of a solution using the °Brix index. However, their accuracy can be affected by the presence of air bubbles, particles, or other impurities in the sample. Refractometers typically also have a limited range of measurement, which may not be suitable for high sugar concentrations or samples containing other dissolved solids. Finally, frequent calibration is also often required, which can be both difficult and time-consuming. Due to these practical shortcomings, different alternatives have been developed, including NanoCuvette™ One for use in a cuvette-based UV-Vis spectrophotometer.
|Figure 3: NanoCuvette™ One data is analyzed using SpectroWorks™ cloud software at https://spectroworks.com/.|
As an alternative, NanoCuvette™ One is a novel technique that offers a user-friendly procedure
for refractive index measurements. As a feature, NanoCuvette™ One utilizes existing spectro-photometers and the SpectroWorks™ software to accurately measure refractive index, °Brix index and sucrose concentrations.
With NanoCuvette™ One, the benefits include that results are not affected by impurities, have a wide refractive index range, and do not require calibration for precise measurements.
NanoCuvette™ One creates instant value in any laboratory and quality control station. It relies on the existing spectrophotometer instrumentation in laboratories. Therefore, as a refractometer instrument is not needed, the measurement can be performed without upfront investment, calibration or training.
2 Method and Instrumentation
Instead of re-inventing a new optical apparatus, our technology NanoCuvette™ One is a novel cuvette containing samples for widely used spectrophotometric experiments and with an advanced optical analysis available in the online cloud software SpectroWorks™, see Figure 3. Our core technology introduces a disruptive design, allowing spectrophotometer users to measure both the absorbance and refractive index, see Figure 1.
Our cuvettes include a surface with a photonic crystal which enables refractive index measurements in a spectrophotometer for the first time, see Figure 5, together with a cloud-based analysis software, see Figure 3.
3 Theory and Working Principle
NanoCuvette™ One is a breakthrough technology that enables accurate and reliable measurements of refractive index using spectrophotometry and label-free spectroscopy. Its advanced optical filter, comprised of nano-scale photonic crystals, allows for precise analysis of the attenuance output spectrum. With an advanced optical model available through the cloud-based software SpectroWorks™, refractive index and concentration can be determined with confidence.
3.1 Absorbance via Absorption Spectroscopy
For background, the Beer-Lambert law is a well-known principle used in absorption spectroscopy, which allows for the determination of the concentration of a substance in a solution based on its ability to absorb light at a particular wavelength, see Figure 4.
With absorption spectroscopy, the Beer–Lambert law relates the attenuation of light to the properties of the material through which the light is traveling:where A is the absorbance, ε is molar extinction coefficient, C is the concentration, l is the path length and A₀ is the background absorbance.
3.2 Refractive Index via Label-free Spectroscopy
In label-free spectroscopy, light is used to study the properties of nanoscale photonic crystals. With NanoCuvette™ One the software uses a new type of optical filter (optical chip or photonic crystal) which is inserted into the light beam and the spectrophotometer measures the refractive index by measuring a wavelength color shift on the x-axis at fixed intensity that is proportional to the concentration or sample change in the NanoCuvette™ One, similar to David B. Hand's law for proteins . When light interacts with the photonic crystal, it creates a resonance at a specific wavelength that is related to the refractive index or concentration of the material near the crystal’s surface. In the simplest linear model, the resonance wavelength, λR, can be described using the equation:where λ₀ is a reference wavelength, β is a coefficient, and nD is the refractive index of the sample. By measuring the resonance wavelength, the refractive index can be determined. A comprehensive computational model for calculating refractive index based on UV-Vis spectra is built into SpectroWorks™.
3.3 The °Brix scale
°Brix is a unit of measurement used to express the sugar content of a liquid solution, typically in the context of the food and beverage industry. It is named after the Austrian scientist Adolf Brix, who developed the °Brix scale. The °Brix value is determined by measuring the refractive index of a solution and can be used to estimate the sugar content in a variety of liquids, such as fruit juices, wine, and honey. The refractive index is a measure of how much a substance bends light, which is related to its concentration and composition. The °Brix scale correlates the refractive index of a solution with the percentage of sucrose by weight. For example, a °Brix value of 10 indicates that the solution contains 10% sucrose by weight. °Brix is primarily used in fruit juice, wine making, carbonated beverage industry, starch and the sugar industry.
Dissolution of sucrose and other sugars in water changes not only its specific gravity but also its optical properties, in particular its refractive index and the extent to which it rotates the plane of linearly polarized light. The refractive index, nD, for sucrose solutions of various percentages by mass has been measured and published. When refractive index is used, the °Brix value can be obtained from the polynomial fit to the ICUMSA table :
where nD is the refractive index measured at the wavelength of the sodium D line (589.3 nm) at 20 °C. Temperature is often important and specified for a particular measurement as refractive index changes with temperature. The above equation for °Brix values is built into SpectroWorks™.
4 Measurements, materials and methodsThis section describes the measurements, materials and methods related to the use of NanoCuvette™ One. Please note the following:
- Deionized water reference and the sample should be measured in the same cuvette.
- If reusing the same cuvette for additional sample measurements, we recommend a washing and cleaning step (see our recommended wash protocol on our website).
- For high-precision applications, we recommend to use a new cuvette with respective deionized water reference measurements for each sample measurement.
4.1 Materials and apparatus
- Sucrose Product no. S9378-500G stock from Sigma Aldrich.
- Shimadzu-UV1800 double beam spectrophotometer instrument.
- NanoCuvette™ One used for measurements. For this application note 15 mm beam height NanoCuvette™ One was used due to the height 15-20 mm of light beam in a scanning type spectrophotometer (UV1800).
4.2 Safety Precautions
- Please refer to common laboratory practices.
- This method does not require any safety precautions.
- The NanoCuvette™ One is made of PMMA plastic and can be disposed as plastic waste.
4.3 Instrument preparation
- Start spectrophotometer, warm up for 30 min.
- Perform Auto zero (without cuvette).
- Perform System baseline (without cuvette).
Choose the scan method in the spectrophotometer with a wavelength range of 1100 nm - 190 nm (and the specified parameters e.g. Shimadzu-UV1800 ‘slow-scan-mode’ with 2.0 nm wavelength resolution).
4.4 Reference measurement
- Take NanoCuvette™ One from the box.
- Add 3000 μL DI water.
- Make sure there are no air bubbles.
- Capture the box number, cuvette number.
- Measure side B of the DI Water.
- Empty the cuvette, and let it dry.
See Figure 5 for the different orientations of the NanoCuvette™ One.
|Figure 5: Method for use in a spectrophotometer. Side A/B positions and orientations of NanoCuvette™ One for use with 1 cm path length cuvette-based UV-Vis spectrophotometers. First measure the Side A position by inserting NanoCuvette™ One into the instrument sample cuvette holder such that the optical filter is NOT in the light path (Side A). Then turn the NanoCuvette™ One 90 degrees into the side B position, such that the optical filter is facing towards the light source when illuminated (Side B). Please see our UV-Vis Knowledge Base for more information on the specific orientation of light source and detector for different UV-Vis instrument models.|
4.5 Sample preparation
Pure sucrose is dissolved in deionized water to a concentration corresponding to 50 °Brix.
A stock solution can be prepared as follows:
- Weigh out a quantity of 50 g of pure sucrose.
- Add 50 g of deionized water.
- Mix until the solution is fully dissolved
From this stock solution (50°Brix), make a standard curve in a serial dilution from 50 °Brix to 1.5625 °Brix using deionized water, see Table 1. Mix the solutions between dilutions.
4.6 Sample A & B side measurements
See Figure 5 for the different orientations of the
We are continuing in the same NanoCuvette™ One which was used for DI Water reference.
Measure the serial dilution with increasing °Brix value, starting at lowest °Brix concentration 1.5625 °Brix. Wash the cuvette between each sample.
- Add 3000 μL of the diluted sucrose sample.
- Check that no air bubbles are present.
- Measure A side of sample. (Measure without the photonic crystal towards the light path).
- Measure B side of sample. (Turn the cuvette 90 degrees to the light path and measure through the photonic crystal).
4.6.1 Data Analysis
- Log into https://spectroworks.com/ (online software).
- Create your login and password.
- ’Degrees Brix’
- ’Protein Concentration’
- ’Sample fit quality’
- ’Reference fit quality’
- As a project is created, it will lead to ”Get started with full spectrum analysis”.
- Select the NanoCuvette™ One functionality.
- Enter the six character box code found on the back of the NanoCuvette™ One box and select the cuvette number.
- Select fluid material, H2O (Optical parameter for solvent) and accept.
- Click ”NEXT”.
- Upload or drag & drop the B-side spectrum from DI water onto SpectroWorks™.
- The software will analyze reference data and load results for ”Reference fit”. Click ”NEXT”.
- Upload or drag & drop the A-side spectrum from sample onto SpectroWorks™.
- Upload or drag & drop the B-side spectrum from sample onto SpectroWorks™. Click
- The software will now analyze sample data and load results for ''Sample fit''. Click ''NEXT''.
- The software will now calculate “Degrees Brix” and load results. Click ''NEXT''.
- The software will now calculate the “Protein Concentration” and load results. Click ''Finish''.
- Finally, the software will load summary and load results for ''Summary''. It is possible to add all information about the measurement in the ''Sample attributes''. Under ''Plots'' the spectra can be seen.
The results section presents the data obtained from the measurements using NanoCuvette™ One and the analysis performed with SpectroWorks™ software. The data collected from a series of sucrose dilutions demonstrates the ability of the technology to accurately determine the °Brix values and sucrose concentrations.
5.1 Reference and Sample Spectra
Figure 5 illustrates the two specific orientations of the NanoCuvette™ One when placed inside a spectrophotometer. The input data for the SpectroWorks™ online cloud software includes the Aside and B-side spectra from both the reference (DI water) and the sample measurements. Figures 6a and 6b display the example reference spectra expected from deionized (DI) water.
In the A-side spectrum, light interacts solely with the deionized (DI) water. As there is no absorbance of light in the visible range for deionized (DI) water, the spectrum is flat, as seen in Figure 6a. The B-side spectrum, shown in Figure 6b, captures the resonant spectrum of light passing through the optical filter containing the photonic crystal. The resonant peaks between 750-700 nm (TE mode) and 650-700 nm (TM mode) result from the interaction of light with the photonic crystal and are expected in the analysis.
(a) Spectrum without the photonic crystal of DI
(b) Spectrum of DI water with the photonic crystal facing the light path closer to the light source. (B-side).
|Figure 6: Example spectra.|
5.2 Standard Curve and °Brix Analysis
The standard curve of sucrose was obtained by measuring a series of sucrose dilutions with the NanoCuvette™ One and analyzing the data using SpectroWorks™ software. The resulting °Brix values and sucrose concentrations were determined and are presented in Table 2. Figure 7 displays a graphical comparison of the results, demonstrating a strong correlation between the measured °Brix values and the known sucrose concentrations.
The results demonstrate the accuracy and reliability of the NanoCuvette™ One technology in determining °Brix values and sucrose concentrations across a wide range of concentrations. The strong correlation between the measured and known values, along with the consistency in the measurements, supports the suitability of this technique for various applications in food and beverage industries, research, and quality control.
The results obtained using NanoCuvette™ One and the UV-Vis spectrophotometer, coupled with SpectroWorks™ software, demonstrate a reliable and accurate method for measuring sugar content in terms of °Brix index and sucrose concentration. The NanoCuvette™ One technology overcomes several limitations associated with traditional refractometry, including sensitivity to air bubbles, particles (or other impurities), limited measurement range, and the need for frequent calibration. By utilizing existing spectrophotometer instrumentation and cloud-based software, this method allows for efficient and precise analysis without the need for significant upfront investments or extensive training.
The NanoCuvette™ One technology is particularly advantageous for food and beverage manufacturers, researchers, and students who require a robust and accurate method to determine sugar content in solutions. The wide refractive index range and insensitivity to impurities in the sample make this method suitable for various applications, from quality control in production processes to research and development of new products.
The standard curve of sucrose dilutions, as demonstrated in Table 2 and Figure 7, indicates a strong correlation between the °Brix index and sucrose concentration measurements. This correlation showcases the accuracy and reliability of the NanoCuvette™ One technology in determining sugar content. The method can also be extended to other applications, such as protein concentration measurements, by utilizing the label-free spectroscopy technique and adjusting the SpectroWorks™ software parameters accordingly.
In conclusion, NanoCuvette™ One offers a viable alternative to traditional refractometry for measuring sugar content in solutions, specifically through the °Brix index and sucrose concentration measurements. The technology capitalizes on existing spectrophotometer instrumentation and cloud-based software, ensuring accurate and reliable results without significant investments or extensive training. The method is well-suited for food and beverage manufacturers, researchers, and students, and can be extended to other applications, such as protein concentration measurements, with minor adjustments to the software parameters.
By overcoming the limitations of traditional refractometry, such as sensitivity to impurities and the need for frequent calibration, NanoCuvette™ One proves to be a valuable tool for determining sugar content in various applications. The wide refractive index range and insensitivity to impurities make this technology particularly beneficial for quality control and research as well as development purposes across various industries.
 David B. Hand. The refractivity of protein solutions. The Journal of Biological Chemistry,
108(3), 1935. 3.2
 ICUMSA Methods Book. op. cit. edition. Specification and Standard SPS-3 Refractometry and
Tables – Official; Tables A-F. 3.3
FOR RESEARCH USE ONLY.
NOT FOR DIAGNOSTICS.


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Altamont is proud to announce the first EP release of The Goat & the Occasional Others on the 10” vinyl format. The Goat is Andrew Reynolds and Thug Shizza, joined on this recording by Occasional Others Beagle Oneism and Spankdizzle. Side A: Armageddon, Side B: Luv Dat Shit! This recording was made as a promotional item and distributed in extremely limited quantities to authorized Altamont dealers with the Fall 2008 catalog.
What To Read Next

domain: artistic


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Autism Empowerment is a nonprofit 501(c)3 organization based out of Vancouver, WA dedicated to enriching and empowering the lives of children, teens, adults and families within the Autism and Asperger communities. We serve all ages and abilities proactively, positively and professionally.
The vision we work toward is an inclusive society that accepts and respects all youth and adults on the autism spectrum and empowers each person to reach his or her highest potential. We offer innovative and inspiring programs, trainings and services and opportunities for leadership and volunteerism for those within and supporting the Autism and Asperger community.
Everyone on our Board of Directors is on the autism spectrum or closely related to someone who is. We are proactive autism allies that believe each one of us is an Ambassador for Acceptance of All Abilities in our home, in our family, in our community and in the world.
Our Acceptance for All Abilities philosophy promotes inclusion. You will find us collaborating with and supporting other autism and cross-disability related organizations around the world. We also work with organizations that are not autism related in order to help their members better understand life on the autism spectrum.
We serve all ages and abilities and promote Four Foundational Pillars of Positivity:
Accept - Enrich - Inspire – Empower
We appreciate you taking the time to visit the Autism Empowerment website. We are a positive organization that focuses on individual, family and community education, outreach and support. We do this by providing meaningful resources, informational articles and offering a wide range of innovative programs and services that promote Acceptance, Enrichment, Inspiration and Empowerment within the Autism and Asperger communities.
We invite you to learn more about our Mission & Vision as well as our Core Values, Beliefs and Goals. We strongly believe in creating an Autism Empowerment community where all people on the autism spectrum and those supporting them feel welcome. All ages, all abilities. All cultures, all socio-economic classes. All are accepted and welcome here.

domain: sociology


The Xiaomi Redmi K40 is powered by a Qualcomm SM8250-AC Snapdragon 870 5G (7 nm) CPU processor with 128GB 6GB RAM, 128GB 8GB RAM, 256GB 8GB RAM, 256GB 12GB RAM, UFS 3.1. The device also has a 6.67-inch Super AMOLED (1080 x 2400 pixels, 395 ppi) display. It has a Triple: 48 MP, f/1.8, 26mm (wide), 1/2", 0.8µm, PDAF + 8 MP, f/2.2, 119˚ (ultrawide) + 5MP rear camera and supports Wifi, NFC, GPS, 3G, 4G LTE and 5G. It packs in a Li-Po 4520 mAh, non-removable battery at 7.8mm device thickness and weight 196g, running on Android 11, MIUI 12.
The latest Xiaomi Redmi K40 price in Malaysia market starts from RM1498. It is available in Black, White, Aurora colours.
Rate & Review now via the TechNave APP and win yourself a branded new smartphone weekly.
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When it comes to TVs, many think of them as plain black boxes to watch movies or TV shows. Quite often, they don't fit in with artful decor, prompting many people to hide their TVs completely in such situations. But what if your TV could also blend in with all your art pieces?
Say hi to Samsung's The Frame, an out-of-the-box smart TV that not only displays stunning visuals but also looks as good as any other masterpiece. It comes with many features that make it rather unique, compared to other TVs. In no particular order, here are 3 reasons why you may want to make The Frame a part of your living room.
| Mobile Phone
| iPad & Tablets
| Cameras & Camcorders


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24-hour emergency dentist in Fayetteville, TN
Don't let dental pain control your life. Call now and book an emergency dentist near you in Fayetteville. We're open 24 hours a day, from Monday through Sunday.
Our Fayetteville dental team is standing by. Call us 24 hours a day, including weekends, nights, and after hours.
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Get instant help with severe toothache, broken tooth, and other dental emergencies. We accept walk-ins and same-day appointments.
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Emergency dentist open 24 hours near you in Fayetteville
At Authority Dental, our mission is to provide swift and reliable connections to nearby emergency dentists for folks dealing with severe tooth pain, cracked or chipped teeth, and severe tooth sensitivity. We aim to offer round-the-clock support for urgent tooth extractions or any dental emergencies. Remember, when you're in need, Authority Dental is here to guide you to the immediate relief you need.
Symptoms of a chipped tooth
A chipped tooth doesn't always demand professional treatment, but if you experience severe dental pain or a jagged surface, it becomes essential. The location of the chipped tooth influences restorative dentistry options. Front teeth may need veneers or bonding, while molars might necessitate crowns. Ensuring toothache relief is our priority. Your nearby Fayetteville 24-hour emergency dentist is ready to serve you.
Taking care of oral bleeding
Oral bleeding in adults isn't rare. Ever wonder why it's more common in smokers? Smoke damages the gums and reduces the blood flow, making them more vulnerable to infection and bleeding. Plus, restorations using pharmacologic agents could be at risk due to the body's immediate reaction to tobacco. So, if you're experiencing bleeding, let's schedule an appointment together. Our office is ready to help.
Emergency root canal near you
Recognizing the need for a root canal involves your discernment of signs like severe tooth pain, prolonged sensitivity, gum swelling, or a tooth darkening. Post-root canal, you're probably wondering about resuming life as normal. Generally, endodontic therapy has a swift recovery period. You can expect to return to eating, brushing, and exercising within 24 hours. However, if an infection persists, a root canal retreatment might be necessary. Here, at our 24-hour emergency dental practice in Fayetteville, we're dedicated to managing these urgent needs. Remember, if you're concerned about dental pain, don't take a risk—rely on professional care near you.
What to do with a cracked crown
Reasons your crown may have broken can include teeth-grinding habits, eating hard foods, or even using teeth to open bottles. Yes, a broken dental crown necessitates a professional's eye. Our same-day dental care in Fayetteville allows for immediate crown repair by a dental specialist. We recommend scheduling an appointment for timely resolution.
Jaw pain relief
Jaw pain, often characterized by a consistent or intermittent ache, can indicate underlying conditions like TMJ disorders. This discomfort can be alleviated temporarily through remedies such as heat compresses. Persistent pain may require the use of mouth guards to prevent grinding during sleep, a common issue for those with sleep apnea. If such pain persists, an immediate emergency dental appointment would be best to ensure swift, effective treatment.
Dental treatments for toothache
To differentiate between a regular and serious toothache, consider intensity and duration; a severe or lasting ache signals a possible bacterial infection. Foods rich in sugar escalate toothaches. Seek an emergency dental check-up if you experience unbearable pain, or a bad taste suggestive of infection. Opt for acetaminophen for temporary pain relief.
What areas do you serve?
Why is ibuprofen not working for my toothache?
How long can a tooth infection go untreated?
Should I visit the emergency room for dental emergencies?
What happens if you don't remove a decayed tooth?
24/7 dental care near you in Fayetteville
Take the first step towards a healthier smile and schedule your appointment today. We're open 24 hours a day, from Monday through Sunday. Call now and enter your ZIP code.1-888-488-0618

domain: medical


text:
What Ethereum [ETH] traders can expect from Q4
Ethereum has been in the heat of discussion on social media since last week’s merge announcement. However, not everything went according to plan as the ETH price fell below $1,350.
In fact, Ether’s weekly loss is now over 17%, according to CoinMarketCap. But Anonymous Crypto Enthusiast (@cryptogucci) believes that all hope is not lost for Ethereum in a recent tweet thread.
In the last 48 hours #etheriumA quick thread🧵
— Crypto-Gucci.eth ᵍᵐ🦇🔊 (@CryptoGucci) September 21, 2022
Back on track soon?
Analyst sparks conversation about Ethereum validators who surged over 11.36k in September alone.
Ethereum now has over 429.6k active validations on the network This late growth of online validators indicates a growing investor confidence in the technical perspective of the merger.
That being said, leading NFT marketplace OpenSea has now extended its support to Arbitram. open sea announcement The news came in a tweet yesterday (September 20) claiming that users will now be able to buy and sell NFTs on the Ethereum Layer 2 solution.
NFTs will start rolling on Arbitram from September 21 only without any delay
But but but
Despite this dose of optimism, the situation remains bleak for Ethereum and the crypto market. Top crypto assets like BTC and ETH are still struggling in the market.
At press time, Bitcoin was trading below $19k while ETH was available at around $1,330. Both tokens have dipped in the past days and continue to be influenced by macro factors.
The same is true for Ethereum traders in light of falling prices. Ethereum’s MVRV ratio is now down to -13.6% as profitability has fallen drastically over the past week.
This process was further fueled by a major sell-off following the merger event. Trader sentiment remains an important cog for the short-term recovery of assets that are currently in dire straits.
Here is another sluggish side observed in Ethereum today (September 21). According to the Blockchain Analytics Platform glassnodeEthereum’s median transaction volume has dropped to an all-time low of 0.032 ETH.
This is a clear reflection of the depressed state of trader sentiment in Ethereum right now with many looking to reduce their ETH exposure.
Another issue for Ethereum is the growing negative sentiment from the crypto community. According to the data below, we can see how FUD is settling into the crowd despite the “highly anticipated” merge event. It looks like Ethereum is looking to end Q3 on the same note as the previous quarter.

domain: economics


text:
Monday Mourning - Temperance Brennan, Bk 7 - Unabridged Audio Cassette Author:Kathy Reichs Temperance Brennan, forensic anthropologist for both North Carolina and Quebec, has come from Charlotte to Montreal during the bleak days of December to testify as an expert witness at a murder trial. She should be going over her notes, but instead she's digging in the basement of a pizza parlor. Not fun. Freezing cold. Crawling rats. And now, t... more »he skeletonized remains of three young women. How did they get there? When did they die?
Homicide detective Luc Claudel, never Tempe's greatest fan, believes the bones are historic. Not his case, not his concern. The pizza parlor owner found nineteenth-century buttons in the cellar with the skeletons. Claudel takes them as an indicator of the bones' antiquity.
But something doesn't make sense. Tempe examines the bones in her lab and establishes approximate age with Carbon 14. Further study of tooth enamel tells her where the women were born. If she's right, Claudel has three recent murders on his hands. Definitely his case.
Detective Andrew Ryan, meanwhile, is acting mysteriously. What are those private phone calls he takes in the other room, and why does he suddenly disappear just when Tempe is beginning to hope he might be a permanent part of her life? Looks like more lonely nights for Tempe and Birdie, her cat.
As Tempe searches for answers in both her personal and professional lives, she finds herself drawn deep into a web of evil from which there may be no escape. Women have disappeared, never to return... Tempe may be next.
Read by Michelle Pawk, unabridged on 6 cassettes, running time approximately 10 hours.« less

domain: library


We provide cloud services that accelerate your business growth with greater efficiencies, effectiveness, and scalability.
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Our work fundamentally changes the way businesses and industries operate, creating measurable value for our clients, end users and society. Talk to our business development team about working with GI and how we can help you transform.


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A new study of 2,000 UK consumers by Sungard Availability Services (Sungard AS) reveals more than one in ten (17 percent) would sacrifice spending the festive season with family or friends to ensure all the online services they currently use remain constantly available. The figures rise to one in five men (20 percent) and nearly a quarter of 16-24-year olds (22 percent) demonstrating the nation’s reliance on digital availability in 2020.
Findings from the new study highlight that UK households expect to be most reliant on online grocery deliveries (22 percent), entertainment streaming (21 percent) and online retailers (21 percent) over the holiday period. And aside from giving up time with friends and family, men appear more tied to digital experiences, with 34 percent prepared to forego a month’s worth of chocolate consumption (compared to 32 percent of women) and 12 percent happy to lose a day’s wages to ensure access (compared to 10 percent of women).
With digital availability having a huge impact on both human relationships and mental wellbeing for consumers in 2020, the study also sheds light on the consequences of accessibility suddenly being removed:
- Half (49 percent) of respondents believe their mental wellbeing would suffer if they were left unable to access online services over the holidays for 48 hours
- Over a third (35 percent) stated a relationship with a partner would suffer if they were left unable to access online services for 48 hours, with 6 percent admitting this would suffer in less than hour
- In 7 percent of cases, mental wellbeing would suffer in less than an hour, rising to 12 percent amongst 16-24-year olds
As many businesses continue to struggle and look to online offerings to make the most of what is usually a golden quarter, results from the study show ‘access to services whenever I need them’ charts as a top consideration for future purchases amongst consumers in over a third of cases (37 percent). Tolerance of downtime is low too, with 15 percent of respondents stating they would switch provider after only one day if left unable to access a service.
“The message to businesses this festive season is clear – stay available or risk valuable customers going elsewhere,” comments Chris Huggett, SVP EMEA at Sungard Availability Services. “An uncertain year looks set to end in an uncertain way, with a patchwork of restrictions likely to remain in place for some time. Consumers have been highly reliant on technology to help them cope in 2020 and this looks set to continue in the weeks ahead. Companies must ensure availability is front of mind. It’s the only way to safeguard services and ensure crucial opportunities amongst captive audiences aren’t jeopardised, at crucial time of the year, where every penny counts.”

domain: news


- Page 1: Introduction
- Page 2: Design
- Page 3: Connectivity & Ports
- Page 4: Display
- Page 5: Cameras
- Page 6: Software - Android 8.0 Oreo with Samsung Experience 9.0
- Page 7: Performance & Gaming
- Page 8: Battery & Charger
- Page 9: Wrapping up the Samsung Galaxy A7 (2018) review
Battery & Charger
Knowing the performance of the Exynos 7885 and the magic of AMOLED displays, the Galaxy A7 (2018) is looking pretty good in terms of battery life even though it has a 3,300mAh battery only.
In our usual PCMark battery life test, the Galaxy A7 (2018) can actually last quite a long time – just as efficient as the Snapdragon 636 chipset.
In the world of smartphones these days, we’re presented with 5V 2A chargers as a standard. However, the Galaxy A7 (2018) comes with a 5V 1.55A charger instead. It’s… definitely slower than the commonly-found chargers that we have.
But objectively, how does the 5V 1.55A charger competes? Take a look at the graph below.
Surprisingly, it doesn’t seem to matter if we’re using the included 5V 1.55A or a 5V 2A charger. From the looks of it, the charging speed is limited by the phone itself.
Both chargers will take about 43 minutes to reach 50% of battery charged, and a total of 77 minutes to reach 75% of battery charged. Obviously, it’s not fast.


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THE opening of Fiji's embassy in Seoul, Korea has widened the scope of trade and investment between the two countries.
Speaking at the Fiji-Korea Business Forum and Catalogue Exhibition on Thursday, Fiji Revenue and Customs Authority chief executive officer Jitoko Tikolevu said the establishment of the mission was symbolic of government's commitment to actively engage with the international community.
"As international trade continues to increase and Fiji's economy continues to expand, the Fiji government is committed to ensuring that transparency, stability and integrity form the foundations of our economic development," Mr Tikolevu said.
He said this had contributed to investor confidence by foreign businesses in Fiji.
The embassy was opened in July this year to open up trade and investment opportunities and encourage closer relations.
Fiji has had diplomatic relations with Korea since 1971.
"Fiji and Korea have had a close relationship for more than four decades and in that time Fiji greatly benefitted from technical and developmental assistance provided by the government of the Republic of Korea," he said.
"There are many more incentives through duty concessions that are available to investors, not to mention tailor-made incentive packages to suit your investment needs," he said.
Mr Tikolevu also said the Fiji government recognised the economy's development was catalysed by investment.


Cranchi’s 78ft Settantotto to Feature Volvo Penta’s 1,000hp Engines
Cranchi will celebrate its first 150 years with the launch at Boot Dusseldorf of a 78ft flagship featuring Volvo Penta’s most powerful IPS engines.
Historic Italian builder Cranchi is set to celebrate its 150th anniversary in 2020 with the world premiere of a new 78ft flagship, Settantotto, at Boot Dusseldorf in January. Propulsion is supplied by triple Volvo Penta D13-IPS1350 engines, the most powerful in the IPS range, each delivering 1,000hp.
With an overall length of 81ft 6in, Settantotto is expected to reach a top speed of 32-33 knots, while other benefits from Volvo Penta’s IPS include reduced consumption, vibrations and noise. The Settantotto is the latest example of the historic partnership between Cranchi and Volvo Penta, which began in 1967.
The two companies celebrated earlier this year when the T36 Crossover – combining the designs of a trawler and a cruiser – won European Powerboat of the Year 2019 in the under-45ft category, with the awards held the day before Boot Dusseldorf. The T36 Crossover is fitted with twin Volvo Penta D4-300hp engines.
Guido Cranchi, CEO of Cranchi Yachts, says the award, the upcoming flagship and the world premieres of the E26 Classic and E26 Rider at last year’s Cannes Yachting Festival represent a new phase for the builder, which was founded in 1870 and is now owned by the fourth and fifth generations of the Cranchi family along with members of the Monzino family.
“The T36 Crossover initiated a new phase of renewal of our range,” Cranchi said. “The T36 Crossover, as well as the E26 that we presented last summer or the Settantotto that will debut at the beginning of next year, shine for their quality and originality. They offer the market something new.”
Cranchi, which has two production plants near Lake Como in Lombardy, has worked with Volvo Penta for over five decades and was one of the first companies to use the Inboard Performance System (IPS) when it was launched in 2005. Cranchi’s Mediterranee 43 HT, launched two years later, was hailed for its beautiful styling and impressive IPS technology.
Another milestone in the relationship was reached when Cranchi selected Volvo Penta IPS for three of its new Evoluzione flybridge models in 2016. The E52 F flybridge and E52 S hardtop yachts are both powered by twin Volvo Penta D8-IPS700s, while the E56 F flybridge yacht can be powered by either twin D11-IPS800s or D11- IPS900s.
Aldo Cranchi, one of the company’s owners, said: “We have established a great partnership with Volvo Penta over the past 50 years, and it is a collaboration that we very much appreciate. Both of our companies have changed a lot over this time, but together we have shown that beautiful design and technological advancements work very well in harmony.”
Cranchi makes several series of leisure boats including trawlers, crossovers, hardtops, cruisers, sport-lines, outboard vessels and flybridges. Today, Volvo Penta takes part in Cranchi’s dealer meetings, to discuss the ways in which its engines and IPS models add value to an owner’s experience.
Nicola Pomi, Volvo Penta’s Vice President Marine Europe, added: “Our relationship with Cranchi has come a long way over half a century, and we both have a philosophy of exploring new ideas. It is that spirit of combining new technology with traditional design and craftsmanship, that has seen Cranchi keep producing beautiful and high-quality new yachts.”
The original article appears in Yacht Style Issue 49. Email firstname.lastname@example.org for print subscription enquiries or subscribe to the Magzter version at: www.magzter.com/SG/Lux-Inc-Media/Yacht-Style/Fashion/


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Giant cell granuloma is being treated with marijuana
Giant cell granuloma is a benign form of cancer that causes seizures and results in painful tumors growing on the jaw. There are pharma-created drugs that can be prescribed to fight the disease, but many carry horrible side effects and don’t work quickly enough to reduce the symptoms. For some, such as 13-year-old Rylie Maedler who only wanted to live a normal teenager’s life, the lab drugs were not the solution. However, she found an alternative that worked better and has helped her win her life back – cannabis.
In an interview with InsideEdition, Maedler stated, “In second grade, my face started to grow and it was getting bigger, and my mom decided to take me to the hospital. I was just so uncomfortable. Seeing my face in the mirror made me really sad.”
After trying to control the disease with lab-based drugs, Rylie’s mother turned to cannabis, desperate for a better solution. Although hesitant at first over concerns of possible side effects, the treatment exceeded her expectations. The seizures stopped completely and the tumors shrank into nothing. Prior to beginning the cannabis treatment, her doctors had warned her that her teeth would fall out – she is now all smiles with her own set of pearly whites. Rylie exclaims, “Cannabis oil made me feel so much better.”
So much better, in fact, that she has become a crusader for medical marijuana. She is behind three laws that were pushed through Delaware’s Congress that helped pave the way for access to medical marijuana by children. She states, “It was illegal when my mom gave me cannabis. It made me feel so much better and I didn’t understand why other kids couldn’t have it, so I wanted to help those kids.”
Despite attempts by some pharma pundits to deny or skew the facts, there are real, tangible benefits to marijuana use. While the stigma of only “burners” smoking marijuana to “get high” may still be common with some individuals, the truth is showing the importance of Mother Nature’s wonder drug and is helping to erase that misconception.


In 2009, Arian Foster was just an undrafted player looking for a chance in the NFL.
When the Texans signed the Tennessee running back, Foster still had to earn his spot on the team. After working on the practice squad providing scout team looks, Foster was called up to the active roster for the final six games of the season. Foster contributed on both offense and special teams, but it was late in the regular season when the rookie made his big splash.
In Week 16 at Miami, Foster scored his first career touchdown on a 17-yard run in the second quarter. He finished with 97 yards on 19 carries in Houston's 27-20 win over the Dolphins. Next week in the season finale versus the Patriots, Foster capped off his rookie campaign with two more touchdowns. In his best game of the season, Foster rumbled for 119 yards, caught three passes for 26 yards and gave the NRG Stadium faithful a glimpse of what was to come over the next six years.
Through six games in 2009, Foster rushed for 257 yards on 54 carries, averaging 4.8 yards per carry, and scored three rushing touchdowns. He also added eight receptions for 93 yards, averaging 11.6 yards per catch. That rookie performance catapulted Foster to a 2010 season where he went on to lead the NFL in rushing yards (1,616), rushing touchdown (17) and yards from scrimmage (2,220).
Check out photos of Arian Foster's touchdown against the Jacksonville Jaguars.


Councilman David I. Weprin’s 16-year old twins are like a lot of teenagers: They text-message their friends every few minutes. And they cannot wait to get their driver’s licenses.
It’s a combination their father, a Queens Democrat, worries about. On Friday he will unveil a measure that would ban the sending or reading of text messages while driving within city limits.
“It’s a risk to drivers, obviously, and also to passengers and pedestrians,” Mr. Weprin said in an interview. “You’re not looking at the road and you don’t have both hands on the wheel” when engaged in text-messaging. “The probability for accidents is too high to ignore.”
Mr. Weprin said the bill would be modeled on New York State’s ban on the use of cellphones while driving, which imposes a $100 fine for the first infraction.
He said the proposal was an outgrowth of the crash last summer in the Finger Lakes region of New York State in which five teenage girls riding in a sport utility vehicle died. A police investigation revealed that the driver’s cellphone was being used to send text messages at the time of the accident, in which her car swerved into oncoming traffic and collided with a tractor-trailer.
Mr. Weprin said: “I don’t send text messages. I can read them, but I find the print too small. A lot of this is generational. I’m 52. If somebody sends me a text message, I usually call them.”
Mr. Weprin said his measure would be rendered unnecessary if the State Legislature approved a similar bill that is now pending. But Mr. Weprin, who is running for city comptroller, said that he was announcing his proposal now in part to attract attention. He especially wants to raise awareness about a new system introduced by the New York Taxi and Limousine Commission to dispatch handicapped-accessible taxicabs via BlackBerry.
The taxi drivers are asked to text-message back to the dispatcher if they are available to pick up a passenger who has called the city’s 311 line to request a special cab, Mr. Weprin said.
“The problem with that, of course, is that you’re creating a very dangerous situation,” he said.
The taxi commissioner, Matthew W. Daus, said that the new trial system required drivers to pull over when using their texting devices. “There’s nothing in this bill that’s incompatible with our program,” he said. “We put a lot of thought into this, and in the end we’re still open to changing if it doesn’t work. But we give drivers credit.”
There are currently four states that outlaw texting while driving, according to the Governors Highway Safety Association, a nonprofit coalition of state offices Alaska, Minnesota, New Jersey and Washington and legislation is being considered in 16 others, according to Mr. Weprin’s staff.
Mr. Weprin said that he was hoping to attract more sponsors for the bill before he officially introduces it at the Council’s next meeting, in early September.
Jason Post, a spokesman for Mayor Michael R. Bloomberg, said that as a practice, the mayor did not comment on legislation that has yet to be introduced.
According to a 2006 study by Nationwide Insurance, 19 percent of drivers use text messaging while at the wheel, and that number jumped to 37 percent among drivers aged 18 to 27.
While auto safety groups like the AAA and the makers of handheld devices have stated their support of a ban, it does have the potential to chafe among libertarians and others who deem it an infringement on personal freedoms.
“It’s foolish to drive a car and try to text message at the same time, but to criminalize all stupid behavior is fruitless,” said Joseph L. Bast, president of the Heartland Institute, a nonprofit organization in Chicago that describes its bent as free-market. “I suppose it’s just a matter of time before they try to ban smoking while driving.”
Of course, among highly driven and time-pressed New Yorkers, it can be hard to resist sending a quick text message while stopped at a traffic light or driving on a quiet country road. Former Gov. Eliot Spitzer was recently revealed to have sent text messages from his minivan while driving near his country home in the Hudson Valley.
In transcripts of his e-mail and text-message correspondence with staff members released last month as part of a State Ethics Commission investigation Mr. Spitzer can be glimpsed messaging his spokesman Darren Dopp in response to Mr. Dopp’s query about whether he has read the Sunday papers’ coverage of his nemesis, Joseph L. Bruno, the state Republican leader.
“Haven’t seen,” Mr. Spitzer, a notoriously erratic typist, wrote. “Heading. To twin now.” (He apparently meant town.) And in the next message: “Not a good day for joe.”
As he testified to the commission, he was heading to the nearest newsstand from his country house, which is in Pine Plains.
“Well, this one I was probably BlackBerrying while I was driving,” Mr. Spitzer testified. “The state troopers would let me drive my own minivan to town.”
Then, the Harvard Law-trained former attorney general, referring to the state law banning talking on cellphones while driving, added: “I’m not sure if the statute goes to BlackBerrying, or just the cellphone, or how it defines it, but I may have pulled over.”


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Finding aid and scan (Click on "additional files" below) for Manuscripts Small Collection 493. Receipt from Coles Warehouse, Big Barren River, to the executors of Henry Worthall, for tobacco received. Signed by John Cole and George Russell as inspectors.
History | United States History
Folklife Archives, Manuscripts &, "Coles Warehouse - Warren County, Kentucky (SC 493)" (2012). MSS Finding Aids. Paper 2266.


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Texans brass likely will be done with Carr
The Carr stops here
Top brass likely to go in different direction
Published 6:30 am, Sunday, December 31, 2006
For the past two weeks, all David Carr has done is win. There has been nothing fancy about his game.
There have been no impressive numbers. There has been nothing that would indicate he is the quarterback who can help the Texans make a playoff push.
Over the past two Sundays, Carr has thrown an ill-advised interception and just one touchdown pass. He totaled about as many yards (249) as Peyton Manning on a bad day.
But Carr has been a winner.
Vince Young didn't win Sunday. David Carr did.
If winning matters, then the past two weeks — perhaps Carr's last two in a Texans uniform — should matter when this organization decides if Carr will be part of its future.
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But it won't.
That a hunch is all that's left for Carr to cling to in Houston does not bode well for his future.
After Sunday's 14-6 victory over the Cleveland Browns gave the Texans a 6-10 finish, Kubiak said he would take his time evaluating Carr and every other player. There would be no quick decisions or rash judgments.
But Kubiak knows there is nothing he will see on tape or learn in meetings that he does not already know about Carr.
The Texans already have made their decision. They're just not saying. The consecutive wins to end the year left everyone in the locker room smiling and feeling good going into the offseason. The team tripled its win total from a year ago and saw signs of progress all over the field.
Optimisim is high. In fact, while the Texans went to the field for the second half of Sunday's win, Kubiak had arranged for personalized folders to be placed in every player's locker.
Written on each folder, which included critiques, offseason instructions and schedules for every member of the team, were the player's name and the words "2007 begins today."
Carr's folder could just as well have been left empty. All the numbers and offseason sprints and lifting won't help Kubiak discern any more than he knows today.
In his gut, does Kubiak believe Carr can take this franchise from six wins to eight, nine, 12?
QB still thinking bigYou can look at Carr's 2006 production any number of ways. You can twist and carve quarterback ratings and completion percentages into a million different pieces that would support one opinion or another.
It no more mattered that Carr finished with just 86 yards passing Sunday than it would have if he finished with 286.
In his heart, Carr wants to return to Houston in 2007. He has dreams dancing in his head. He thinks about just how great it would feel to ride out these lowest days of his career and somehow, someday walk off
the Reliant Stadium turf not with a meaningless win over a bad team but with a playoff victory.
"I think it's just endless what we can accomplish," Carr said. "I would love to be a part of it."
But owner Bob McNair echoed Kubiak's words about making no hasty decisions after Sunday's win.
Ultimately, Kubiak is going to look McNair in the face and say yes or no. Carr should stay, or Carr should go.
In the late going Sunday, Carr did some things that should have had fans cheering his toughness and resolve. They should have had the coach saying, "See there. That's why Dave's our guy."
But the fans didn't cheer Carr, and the coach did not endorse him. Both already had seen enough.
Familiar resultsWhen the Texans took the ball after the Browns closed within 14-6 in the fourth quarter, Carr needed to kill time off the clock and move the chains.
His first play was a pass that was batted back in his face. Fans booed. After so many years and so many up-and-down moments, they reacted with their collective gut to a play that could have happened in any NFL stadium.
Carr lay prone on the field for a moment, then dragged himself up, grimaced and went on. He completed another pass to Eric Moulds. And on third-and-2 with less than five minutes remaining, Carr put his head down on a called quarterback run and barreled for a first down.
When he stood, Carr grimaced again, holding his right side, which had been hurt on the hit from Wimbley. Later, on another third down, Carr rolled left, slipped and fell.
These were the last images we saw of Carr in 2006. They were much like so many others over the past five years.
He showed toughness, desire and the willingness to make a play. He showed athletic ability and durability and completed a few safe tosses. He missed on a few others and ultimately wound up on his backside.
All Carr did Sunday was win. Too little, too late.

domain: sports


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Uber has officially launched its food delivery service in Melbourne, with more than 80 restaurants around the inner suburbs already signed up.
Melbourne is only the second city outside of North America to get access to UberEATS, despite UberX still technically being illegal in Victoria.
UberEATS will be available every day from 11am to 10pm and will deliver from Carlton to Windsor, and Richmond to West Melbourne.
Users have to download the separate UberEATS and then it all works largely the same as booking a ride through UberX.
Delivery will be free initially for the launch phase and there will be no minimum price for a food order.
UberEATS Australia general manager Simon Rossi says they chose to launch in Melbourne first because it is the “ultimate foodie city”.
“UberEATS enables us to help more people access to city’s great food from top restaurants in their suburb and beyond,” Rossi says in a statement.
“Our goal is to offer people what they want to eat, when they want to eat, in the quickest time possible.”
“If you want a hot sandwich in the middle of the day, UberEATS might work for you,” Deliveroo Australia country manager Levi Aron told StartupSmart at the time.
It comes as the food delivery market in Australia is increasingly heating up, with the likes of Deliveroo, Foodora and Menulog competing for our appetites.
Controversy has also recently hit the industry, with revelations that riders from Deliveroo and foodora were being paid below the minimum wage and were signed on as “freelancers” rather than employees.
In an interview with StartupSmart, Aron says his riders were paid $20 per hour on average, although the startup is trialling a new model in “busy areas” where riders are paid $10 per delivery with no base rate.
The controversy mainly boils down to the classification of riders and drivers as sole contractors rather than employees, something all the food delivery startups, including UberEATS, have in common.
The post UberEATS has officially launched in Melbourne as the food delivery market becomes an all-out war appeared first on StartupSmart.


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Clinical stage biotechnology firm Visterra has commenced a phase 1 clinical study of VIS649 in healthy volunteers.
VIS649 is a monoclonal antibody targeting the B-cell growth factor APRIL (A Proliferation Inducing Ligand) for the potential treatment of imumuglobulin A nephropathy (IgA nephropathy or IgAN), one of the most common kidney diseases other than those caused by diabetes or high blood pressure.
Visterra president and CEO Brian Pereira said: “We are excited to initiate clinical study with VIS649, a potential therapy tailored specifically to IgA nephropathy, a kidney disease for which there are no approved therapies.
“The current standard of care for progressive IgA nephropathy calls for use of corticosteroids, which are associated with undesirable side effects that can limit their use. A new treatment strategy with an improved benefit/risk profile would be considered a welcome addition by patients and physicians alike.”
Visterra chief medical officer David Oldach said: “VIS649 is a first-in-class monoclonal antibody of the IgG2 subclass and was designed to target the cytokine APRIL, which we believe is an optimal target for the treatment of IgAN.
“Previously reported preclinical data in multiple animal models support clinical evaluation of VIS649 as a treatment for IgAN based on its demonstrated potential to reduce both circulating IgA levels and proteinuria, while also suggesting a favorable safety profile.”
This first-in-human phase 1, randomized, placebo-controlled, double-blind, single ascending dose study will assess the safety of VIS649 in up to 45 healthy subjects. The study will be conducted in up to 5 sequential dosing cohorts at escalating dose levels. Safety, pharmacokinetic (PK) and pharmacodynamic (PD) data from the initial cohorts will be assessed.
VIS649 is an IgG2 monoclonal antibody designed and engineered using the company’s Hierotope® platform to target the cytokine APRIL (A Proliferation Inducing Ligand) and neutralize its biological activity.
VIS649 is in clinical development as a potential treatment for IgA nephropathy. Preclinical data demonstrate the potential of VIS649 to reduce circulating IgA levels and proteinuria, while suggesting a favorable safety profile.
IgAN is a chronic, progressive autoimmune disease characterized by deposits of IgA immune complexes in the kidneys leading to kidney inflammation, hematuria, proteinuria and progressive kidney damage. IgAN is the most common cause of primary glomerular disease worldwide.
The company estimates that each year there are approximately 3,200 new cases of kidney biopsy confirmed IgAN in the U.S. and approximately 185,000 new cases of IgAN worldwide. The prevalence of IgAN varies significantly across the globe, with an estimated incidence of up to 25 per million worldwide. It is estimated that 20 to 40% of patients with IgAN progress to kidney failure or end-stage kidney disease within 20 years of diagnosis, requiring dialysis or kidney transplantation. There are currently no therapies approved for IgAN.
Source: Company Press Release

domain: health


Woods tops list of golfers to make it to ESPN’s World Fame 100 list
With his comeback after recovering from a grave back injury, Tiger Woods has surged up the official world rankings of golfers and consequently, regained his star status. It the third edition of annual World Fame 100 released by ESPN, Tiger has moved up the 6th position from being at No. 10 last year. He has also regained the top spot in the list among golfers, surpassing Phil Mickelson, who dropped to 10th position from No. 5 on the list. The World Fame 100, released last week, is formulated by considering as criteria, social media following, Google trend score and endorsement money. Taking into perspective the reports of gradual decline of golf, it is a happy reassurance to see that 8 of the personalities on the list are golfers. Other golfers who made it to the World fame 100 are Rory McIlroy at 15th, Jordan Spieth at 16th, Justin Rose with No. 69, Sergio Garcia at No. 73, Fowler Fowler at No. 87 and Michelle Wie who came 97th. The top 3 on the list, Cristiano Ronaldo, LeBron James and Lionel Messi have retained their rankings for the second straight year. Get all the latest World Cup betting Tips here.
McIlroy’s sublime performance at BMW PGA Championship
Rory McIlroy’s second round on Friday at the BMW PGA Championship left the crowd as well as fellow golfers stunned, so much so that defending champion Alex Noren said he felt like retiring after being left in awe from watching Rory play what Noren termed as “the best round of golf” he has seen. On Friday at Wentworth, McIlroy put up a flawless second round, earning him a three-shot lead English golfer, Sam Horsfield. The 29-year-old carded a seven-under par 65 without and single bogey, to move to 12 under. Noren, who also had a bogey-free round, is five shots of the lead. However, Noren fans are still hoping, thinking of the stunning round of 62 he put up in last year’s finals, which helped him come out victorious despite initially having lesser chances at the title.
YSD no longer title sponsor of LPGA Malaysia
One of Malaysia’s premier golf tournaments, the LPGA Malaysia received a massive shock after Yayasan Sime Darby (YSD) declared that it would be pulling out from being the title sponsor for the tournament. YSD’s decision to pull out certainly came as a shock, considering the fact that the LPGA Malaysia tournament is scheduled to take place in less than four months. The ninth edition of the tournament is supposed to be staged from 27th to 30th September, but it may not be possible unless the event organisers are able to arrange for another conglomerate to sponsor the $1.8 million tournament.


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MORGANTOWN, W.Va. (May 7, 2021) – Senior left-handed pitcher Jackson Wolf tied his career high with 11 strikeouts in the West Virginia University baseball team’s 7-1 win over Oklahoma on Friday night at Monongalia County Ballpark in Morgantown.
Wolf was dominant all evening, allowing just one unearned run on three hits with one walk in 7.0 innings of work. The Gahanna, Ohio, native earned the win on the mound, his fourth of the year.
The Mountaineers (17-21, 7-12 Big 12) scored four runs in the first inning to build a lead in Friday’s series opener. In all, WVU finished with seven runs on seven hits with two errors, while the Sooners (22-22, 6-10 Big 12) tallied one run on three hits with one error.
OU’s Wyatt Olds took the loss.
After Wolf delivered a 1-2-3 top of the first, WVU struck for four runs in the bottom half, thanks to a pair of home runs in a variety of ways. First, catcher/outfielder Paul McIntosh gave West Virginia a 1-0 lead with a solo shot to left center, before freshman infielder/right-handed pitcher Nathan Blasick tallied a three-run, inside-the-park homer later in the frame.
The Mountaineers totaled four runs on three hits in the inning, all with two outs.
WVU plated two more in the second to extend the lead to 6-0. Sophomore catcher/infielder Matt McCormick drilled an RBI ground-rule double and fifth-year senior first baseman/outfielder Hudson Byorick recorded an RBI infield single to stretch the advantage.
From there, Wolf did the rest. After OU scored an unearned run in the top of the fourth to make it 6-1, the Mountaineer left-hander retired 10 in a row from the fourth to the seventh. He became the first Mountaineer pitcher to register 10 or more strikeouts in three consecutive starts since Alek Manoah from April 5-20, 2019. Wolf threw 117 pitches, including 80 strikes.
WVU’s final run of the night came in the bottom of the seventh when McIntosh scored on a wild pitch.
McIntosh finished 2-for-4 with an RBI and two runs scored in the win, while Byorick also chipped in with a pair of hits. Additionally, Blasick’s three RBI paced the club in the win.
Following Wolf’s exit, redshirt sophomore right-handed pitcher Noah Short pitched two, clean innings in relief. He retired all six batters his faced in the eighth and ninth innings.
With the win, the Mountaineers improved to 12-14 all-time against Oklahoma, including 7-7 at home. The victory also evened WVU’s home record to 10-10 on the year.
Next up, West Virginia and Oklahoma conclude the three-game set on Saturday with a doubleheader, beginning at 3 p.m. ET. Game 2 will begin approximately 30 minutes following the conclusion of Game 1.
Sunday’s regularly-scheduled series finale was moved up due to inclement weather projected in the Morgantown area.
Press Release Courtesy of West Virginia University Athletics Communications


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A sophomore fashion merchandiser at Seattle Pacific University (SPU) is helping the homeless raise donations for an unlikely need.
“It struck us, it was like, ‘Oh … this is a problem,’ and as women we never knew,” said student Ashley Maddox.
The problem? Homeless women are not always able to obtain basic feminine products — tampons and pads.
It struck Maddox as her and friend Samantha McKinney were walking downtown Seattle one day when an old lady came up to them and asked if they would buy her food because she spent all her money on tampons.
“When you’re downtown usually someone comes up to you and asks for money,” Maddox said. “This was different.”
Shortly after the incident Maddox and McKinney started the charity “Padding Her with Love.”
Maddox and McKinney teamed up with Operation Nightwatch, a interdenominational Christian ministry who serve the poor and homeless, for help and to raise awareness for their charity.
“We have just been telling people about it word of mouth and things are going pretty well,” Maddox said. “I have done volunteering, but nothing quite like this.”
Until the Web site is complete, “Padding Her with Love” is technically an unofficial charity.
Trying to inform people about the charity is the hardest part, said Maddox. “We want people to know we are not just asking for money, but for help.”
Maddox and McKinney made their last donation of 700 pads and tampons to Operation Nightwatch in June. They will hold another drive on the SPU campus Oct. 26 through Nov. 2.
They are also looking into setting up branches at Seattle Pacific University sister schools, according to Maddox.
If you are interested in getting involved and or donating, email Ashley.
Visit the “Padding Her with Love” group on Facebook.


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I am so glad I just wrote about my internal rating system, because I think it will be helpful for you all to reference that post while reading this review. Yes, this book was that kind of book.
Fierce, seductive mermaid Syrenka falls in love with Ezra, a young naturalist. When she abandons her life underwater for a chance at happiness on land, she is unaware that this decision comes with horrific and deadly consequences.
This is the ARC cover, so it's the cover I own.
Almost one hundred forty years later, seventeen-year-old Hester meets a mysterious stranger named Ezra and feels overwhelmingly, inexplicably drawn to him. For generations, love has resulted in death for the women in her family. Is it an undiagnosed genetic defect . . . or a curse? With Ezra’s help, Hester investigates her family’s strange, sad history. The answers she seeks are waiting in the graveyard, the crypt, and at the bottom of the ocean—but powerful forces will do anything to keep her from uncovering her connection to Syrenka and to the tragedy of so long ago.
I've known about Monstrous Beauty for some time now. Back when I was just starting to look into industry blogs, I came across a site where the blogger was talking about a mermaid book. I don't remember what blog it was now; I think it may have been Ms. Fama's agent's. Maybe. Either way, I remember the blogger talking about this fantastic-sounding mermaid book that had originally been called Syrenka and was now being changed to Monstrous Beauty.
And then I went on with my life, because the book wasn't out yet, and I was a reader who read things that were out, not a blogger who had to keep up, so what did I care?
Then, once I had a blog and started keeping up with things, that mermaid book kept popping up. People were talking about it. And then I won it! Woohoo!
You'd think with all that forewarning that I would have some idea what I was getting into.
Not even close.
I expected a mermaid tale with some edge. I knew some modern-day stuff would be involved, but I thought the book would be heavy on mermaid and follow some of the same tropes of a mermaid and a human girl teaming up somehow. The curse brings the edge, but whatever.
This book is DARK. Like, Holy-cow-Fama-is-one-twisted-sister dark. Don't expect any singing crabs here. There's murder and betrayal and curses and just out-and-out messed-upness. (Don't judge me on my new words.)
The narrative bounces back and forth between Syrenka's time in the 1800s and Hester's time in the present day, and Ms. Fama handles both with equal skill. Syrenka and Hester are connected, so their narratives weave in and out, tightening as the book progresses.
Syrenka obtains her legs and life with Ezra (not a spoiler; it's right there in the synopsis), but she sets off a chain of events that unfold through the rest of the story. Seriously bad things happen. These bad things keep unfolding and spreading all the way into the twenty-first century where they collide full force into Hester.
Ah, strange, foul-mouthed little Hester. She's spent her entire life throwing up walls. Even her best friend Peter is only allowed so close. Because if you get close to someone, you might fall in love. And if you fall in love, you'll get married and have kids. And in Hester's family, if you have a kid, you die. [Yes, I think in ungrammatical staccato sentences. Deal with it.]
And that's not even half of it. I can't talk about some of the creepiest/most intense parts of the book, because I would be veering sharply into spoiler territory. I don't even watch scary movies, so I don't have a way to subtly prepare you for what you're about to get yourself into. It's like The Sixth Sense mixed with the trailers for those different exorcism movie trailers mixed with those old-timey straight-up Gothic romance novels.
Oddly, I didn't feel much of anything for many of the main characters. They were set pieces for me, moving the plot forward. The only exception is Ezra, who was so very real and so very wonderful. Even more oddly, I didn't mind. I felt sorry for the proper characters (Peter, Linnie, McKee, and especially Ezra), but I was focused completely on the mystery and the craft.
And oh man, what a mystery and what craft! Thanks to dropped hints, I could usually figure out bits before they happened, but Ms. Fama keeps this beautiful pace, dolling out inklings with all the languid certainty of a priest passing Communion wafers. My stomach was in knots, because I knew what was going to happen and I dreaded it all... and yet, at the same time, I wasn't sure that I knew and things might turn out worse than even I could imagine.
I could talk about the writing forever. It's languid in some places, bitingly vicious in others, and beautiful in every single sentence. It's one of those books that I've talked about before, the kind that feels more literary than typical YA books. It's like... like Lady Audley's Secret, but without all the hoke.
As far as ratings go, I'd put Monstrous Beauty alongside Before I Fall. I won't keep it. It has too much language, too much sex, too much what I dub ickiness for me to keep my copy. However, the exquisite plotting and writing earn this book my highest marks.
Points Added For: Craft, creepiness, a haunting setting, fantastic supporting characters, diabolical yet understandable villains.
Points Subtracted For: Absurdedly superstitious and backwards churchgoers/pastors (really, hasn't this malignant stereotype died out yet?), an unnecessary creeper, profanities that got pretty old after a while, an ending that left me going "Now HOW is she going to explain that to her parents?"
Good For Fans Of: Creepy gothic novels, deadly merpeople, gorgeously languid writing.
Notes For Parents: Heavy language, sex, rape, ghosts, murder, talks of exorcisms, nudity.
Disclaimer: I won an ARC copy from Fierce Reads on Facebook.


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The business is the only one of its kind in the UK and has just had written confirmation from the ministry of Justice that my business model can be run without a licence. As confirmed by the MOJ this is the first of its kind and the first to be rolled out commercially hence we were featured and recommended in the Financial Times, Independent and Yorkshire Post Consumer Watchdog pages. In short i help consumers who have suffered financially due to credit rating problems, something that I personally experienced 3 years ago and in which I could find no help out there at the time hence I took up the mantle myself and won two cases against two companies and most recently against a high street bank.
The market is absolutely massive and to be honest its too big to put a figure on in terms of potential turnover.The error rates on Experian records alone are as much as 70%. Importantly with the PPI market dead this is the next PPI.
I unfortunately on my own do not have the marketing budget to get the word out to the Consumers that they should be scrutinizing their credit reports for errors. There has been a land mark high court case regarding the defamation of a persons credit file in the last 7 months in which the consumer was awarded over 10k AND a feature by BBC one\\\'s watchdog service which exposes the errors on Credit reports.
My business has no direct overheads the only costs are small claims and my time. I have absorbed all the start up costs and have a business model that is ready for the right person with the right team behind them . Crucially I also have a fantastic reputation with some of biggest newspapers in the country which is financially worth a lot of money in itself plus I have a loyal Twitter following of over 3500. This will give you the all important trust with potential customers whereby no hard sell is needed as the reputation sells it. I am also looking to rolll out another arm of the business that helps consumers who have been left without representation by the trade unions. In April this year i recorded a precedent against a trade union through small claims for their failure to represent me in a work tribunal. Again the market is massive.


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5 hurt in rollover on Ogden's 12th Street
Saturday , July 19, 2014 - 1:59 PM
OGDEN — Five people were transported to an area hospital Saturday after a rollover accident on 12th Street.
The accident occurred just before noon at 400 W. 12th St., right in front of the No Frills Diner, leaving a white, four-door SUV turned over on its top. The SUV was travelling in the eastbound lane and rolled into an empty field next to the diner.
Ogden Police Lt. Danielle Croyle said a driver in another car was ticketed in the accident and five occupants in the SUV were taken to a local hospital with unspecified injuries.
The accident and subsequent clean-up caused traffic to back up for several blocks in both the east- and westbound lanes of 12th Street.
Contact reporter Mitch Shaw at 801-625-4233 or email@example.com. Follow him on Twitter at @mitchshaw23.
Popular in Police & Fire
SOUTH OGDEN — More goes into a police checkpoint than a couple dozen traffic pylons and a handful of patrol cars — just ask Ogden police traffic Sgt....
OGDEN — While only rain droplets are falling in the valley, Top of Utah mountains are starting to accumulate some of the white stuff. The National...


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We have some beautiful Shiba Inu puppies available. They will come with registration paperwork and their first vaccines and dewormings. Please feel free to call, text or email with any additional questions.
This ad was posted with the eBay Classifieds mobile app.
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domain: pet


text:
Barking is a really typical behavior of dogs as it is their way of communicating withtheir human buddy and other animals. Canine frequently bark to express their sensations to their human buddy. So, sometimes even a correctly behaved pet dog can startbarking continually. There are a lot of reasons that might cause a pet to bark and theirbarking can be extremely annoying. Pets typically bark to cautiontheir human companion of a suspicious activity or a suspicious individual. Dogs may likewise bark because they do not trust unusual peopleor they are unpleasant with the presence of weird individuals in their house. Some pets are utilized by their human companion to alertthem of trespassers and other sort ofthreats. But in some cases incessant barking can be very irritating and disturbing dueto the fact that if your pet is barking all through the night, itcan have an negative effect on individuals living in the same house as thedog and their neighbors. A pet that is barking incessantly can trigger a substantial increase in the stress levels of individuals in the pet dog's environment,this can result in loss of sleep.
Among the most popular ways of managing barking issues in canines is making use of barkcollars. Bark collars is among the most tender ways of managing perpetual barking in pets. It is likewise an effective way of managing barking problems in pet dogs. A bark collar isalso an reliable method of training a pet, although it is not as extensively used as favorable reinforcement.
KINDS OF BARK COLLARS
There are lots of kinds of dog collars in the market today,but the 3 most common kinds of dog collarsinclude;
1. ELECTRIC SHOCK BARK COLLARS COLLARS
The electrical shock bark collars are one of the earliesttype of bark collars on the marketplace. They work by giving the pet dog a mild fixed electrical energy once the vibrations from its vocal cables and barking sounds are found by the sensing units of the bark collars. The electric shock dog collars sends out electric present to pet dog's muscles whenever he barks. The inbuilt prongs is generally used to provide the mild electric shock which can changed inintensity inning accordance with the size of the canine and the training requirements. Nevertheless the specific technique that each individual electrical shock bark collars works depends upon the model and the maker of the electric shock bark collar. Alot of kinds of electrical shock barkcollars emit a moderate electric present when it senses that the pet is barking.Some individuals say that the electrical shock bark collarsare vicious because of the mild electricalcurrent that is sent to the pet dog's body but it isnot likely harm your pet in any way. Theelectric shock bark collars is typically usedto teach a canine to only bark when it is essential and not just barking ceaselessly. Individuals that are using the electrical shock bark collar for the first time ought to begin with a low level setting and increase it slowly as the circumstance needs.
The use of electrical shock bark collars is questionable, but it is extremely effective for controlling relentless dog barking as long as the user has sufficient understanding about it. As well as prevent setting the strength of the electric shocks too high however rather set it to an intensity that is simplyunpleasant sufficient to dissuade the pet from barking. Likewise some electric shockbark collars make use microphone to sense when the canine isbarking. Some collars however utilize both vibration sensing units and microphones to sense when the pet is barking.
2. ULTRASONIC BARK COLLARS
The ultrasonic bark collars are among the most popular bark collars in themarket today. This type of bark collars are used to dissuade canines from barking by utilizingan bothersome yet entirely safe noise. Ultrasonic bark collars typically workby launching a high pitched ultrasonic noise that is stated tobe irritating to dissuade the petfrom barking. They are likewise one of the most effective way of controlling a dog's relentless barking. The bark collar releases a noise when its microphone senses the canine'sbarking that stuns the pet dog without leading to any sort of physical damage. Themicrophones in the ultrasonic bark collars are established to sense special barking, which stops the high pitched ultrasonic noise from unintentionally going off as aresult of other sounds. The high pitched ultrasonic noise given off by the ultrasonic bark collars can not be heard by people but linked here they can be heard by canines, and it only lasts for a couple of seconds. Current studies have revealed that this kind of barkcollars does not have any type of negative influence on the pet dog sincethe duration of the high pitched ultrasonic noise is managed. A number of brand names of ultrasonic bark collarshave a favorable tone function that acts asa positive support when the pet dog stopsbarking.
3. CITRONELLA SPRAY BARK COLLARS
The citronella spray bark collars work by spraying out citronella unto the pet dog's snout whenever the canine startsbarking. The citronella spray typically go for the dog's sense for fast outcomes. The citronella spray barkcollar are created to make the dog link the smell of citronella with barking, so the canine will stopbarking since he does not desire odor thecitronella that is typically released as a consequence forbarking. This is often effective because the fragrance of citronella is extremely displeasing to dogs butit is also absolutely safe. Citronella is generally utilized as an bug sprayby people however it does not trouble humans.
Once the dog starts barking, themicrophone will sense the barking and the citronella spray bark collarwill launch the harmless citronella aroma. It does not need any human intervention to function and it has no negative impacts on the health of the canine, instead it has a calming result on the pet dog. It also take advantage of pets severe hatred of herbal services. The amount of citronella launched must just suffice to stop the canine from barking.
The only disadvantages of using the citronella spray bark collars isthat the fragrance of the citronella might adhereto the pet dog's body for many minutes or hours insome events.


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Black Mage Village
You can reach the Black Mage Village by heading southeast from Conde Petie. You have to go all the way around the cliff face in order to reach the forest and access the village. Use the map and screenshot below to help you.
There is a friendly creature called “Ladybug” in the forest around the Black Mage Village. Ladybug will not attack you - instead it will ask you for some Ore. Use Ore items on Ladybug to end the battle. Ladybug will reward your team with 20 AP for the Ore which is incredibly handy for finishing off any Abilities that characters were learning.
Ladybug is one of many friendly monsters that you can find throughout the game. Check out the Friendly Monster side quest section for more information about where you can find the others and what type of rewards you can receive.
Dead Forest / Grove
You start off by entering the Dead Forest where you will find a sign that reads:
<- Where there are owls
Where there are no owls ->
You have to continue to take the path that leads to the area with no owls. Each time you take the correct pathway you will reach the sam area again but there will be one less owl sitting in the trees. The correct pathway is:
Black Mage Village
Your party will split up as soon as you enter Black Mage Village just as they always do. Vivi will chase after the Black Mages and Dagger will follow him while Quina will wander through the town looking for things to eat. You will have access to three Active Time Events (ATEs) as soon as everybody wanders off:
- “Life On The Run”, following the Vivi and Dagger as they chase the Black Mages through the city
- “Gourmand’s Nose”
- “Everyday Life”
- “Visitor, Not Invader”, Dagger speaking to the Black Mages to convince them that the group is not a threat
- “Different Language”, involving Vivi speaking with the Black Mages to find out more about their story; you need to view this ATE in order to continue the story
Start off by traveling to the northeast to find a Moogle named Mogryo. Mogryo will not be accessible very shortly so it is important that you make speaking with him one of your top priorities. Choose the Mognet option and Mogryo will give you a letter to deliver to Mocchi. Enter the Chocobo Stable to find Quina standing next to two cornered Black Mages. There is a hidden Gysahl Greens item on the right side of the stables that you can pick up.
There is an Item Shop in the next closest hut run by “Black Mage No. 163”. The regular items are on sale but you can also purchase Remedies and Hi-Potions at this store for the first time in the game. There is also a hidden Ether on the left side of the room near the shelf. Exit the Item Shop on the left side and walk down the pathway to watch Vivi go running past.
Enter the next hut over to find Dagger speaking to the two Black Mages inside. This is the Black Cat Synthesis Shop - some of the nicer items up for sale include:
Though you will need to get some of your party members back before you can Synthesize some of the items. There is a hidden chest at the back of the shop that contains 2,000 gil. You can also climb the ladder to the second floor to find a treasure chest at the end of the pathway that contains 843 gil.
Exit the Synthesis Shop, return to the entrance of Black Mage Village and enter the hut on the left side of the screen. This is the Weapon Shop where you can purchase some of the more modern weapons and armor (some of which are needed to synthesize the items listed above).
There is an Elixir hidden to the right of the Weapon Shop door on the outside of the hut (shown in the screenshot below).
Travel down the pathway to the right of the item shop and back towards the Inn in behind it. Vivi can be found back near the bunk beds. All four party members will meet up inside the Inn - choose to Rest. There will be a short few cutscenes involving Vivi learning about Black Mages and death, and a flashback to Zidane’s earlier days, before the entire party will meet up at the entrance to Black Mage Village. There are a few additional things that you should do though before leaving.
There is another Stellazzio coin that can be picked up in the bedroom of the Inn. Search the right side of the room to find the Virgo Stellazzio, part of the Stellazzio side quest. Click on the link for more information.
Travel back up to the second floor of the Synthesis Shop and walk towards the lower edge of the catwalk for an Action Icon to appear. Zidane will eavesdrop on the two Black Mages below who are having a conversation about the Item Shop owner - note that this step needs to be completed first. Go back to the Item Shop and speak to Black Mage No. 163 and ask him to “Give me the usual”.
Travel up the ladder and hop on the bed to find a Black Belt.
Exit the Black Mage Village to automatically be transported back to the World Map. Travel back towards Conde Petie to continue the story. You can take this opportunity to do more Frog Catching though as part of the Frog Catching side quest - click on the link for more information.

domain: game