text:
- Cardiovascular - Cardiology
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- Gene Therapy
- Immunology - Allergy
- Infection - Infectious Diseases
- Obstetrics & Gynecology
- Oncology - Cancer
- Orthopedics - Musculoskeletal
- Orthopedics - Muskuloskeletal
- Psychiatry - Psychology
- Small Molecule
- Urology - Nephrology
- Vascular - Pulmonary
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2015-311 – Mayo Clinic has discovered that HEATR1 is a novel Akt regulator and a predictor for chemoradioresistance.
2015-312 – Mayo Clinic has discovered that the Parkin protein is a mitotic regulator. Cancer cells with deficiency or mutations in Parkin have an increase in mitotic regulator expression leading to tumorigenesis and an increase in sensitivity of Pk1 and Aurora kinase inhibitors. This newly identified mechanism has revealed that Parkin mutations may be used as a biomarker for measuring the sensitivity of... Read More
2015-164 – Mayo Clinic has discovered that WSB1 can be used as a diagnostic marker for tumor metastasis and a therapeutic target.
Methods of Treating Cancer by Using PD1 and PD-L1 inhibitors by Using Soluble PD-L1 Levels as a Biomarker
2008-042 – Mayo Clinic has patent rights claiming methods of using PD1 or PD-L1 antibodies to treat cancer by using soluble PD-L1 levels in the serum as a biomarker.
2003-132 – Mayo Clinic has patent rights claiming methods of detecting the autoantibody associated with NMO.
2004-239 – Mayo Clinic has patent rights claiming the use of PD1 and PD-L1 antibodies to treat cancer. The patent rights also include diagnostic and prognostic claims.
2016-135 – The advent of next-generation sequencing has opened the door to widespread identification of somatic mutations in tumor genomes. These somatic mutations can be utilized to identify “true clonal mutations”, or those that are responsible for driving tumor growth in an individual, and therefore could be useful in the identification of therapeutic targets. The primary issue in the identification... Read More
2014-026 – A peak velocity estimator algorithm for flow phantom spectra. This peak velocity estimator has been adapted for use with Doppler velocity spectra from string phantoms.
2013-186 – The PET imaging agent F-18 sodium hexafluorophosphate (Na[18F]PF6) for hNIS expression in tumors.
2010-312 – The invention relates to the treatment of meningiomas using a composition including a cytotoxic agent and a compound selected from phenylbenzothiazole derivatives, stilbene derivatives, and biphenylalkyne derivatives.
Combining Single Domain Antibody Fragments and Mass Spectrometry as a Diagnostic Test for Patients with Plasma Cell Dyscrasias
2015-146 – Mass spectra of proteins isolated using single domain antibody fragments (SDAF) with affinity for immunoglobulins are used to identify, quantitate, and establish heavy and light chain pairings of M-proteins using MALDI-TOF mass spectrometry. The invention utilizes the unique molecular mass and structure of single domain antibody fragments and the unique molecular mass distributions of heavy... Read More
2015-151 – Several novel naturally processed and HLA presented influenza A/H5N1-derived peptides from a class I HLA-A0201 molecules have been identified. A mass spectrometry approach was used to identify five influenza peptides from a B-cell line (homozygous for HLA-A0201) after infection with influenza A/H5N1 virus. The immunologic relevance and specificity of these identified influenza-derived... Read More
2015-065 – Mass accuracy is used to measure free light chains in serum, urine, CSF and body fluid. The mass accuracy allows for direct quantitation of each kappa and lambda light chain. This technique is useful in the diagnosis and prognosis of multiple myeloma, MGUS, B-CLL, Waldenstroms macrogloblinemia, AL amyliodosis, non-secretory myeloma and for distinguishing an auto-immune response from a... Read More
2015-064 – High mass accuracy is used to measure Igs in CSF and serum. The mass accuracy allows for direct quantitation of each kappa and lambda light chain and can be used as a surrogate marker for active clonal B-cells. This method increases the accuracy of clone matching between serum and CSFand utilizes top-down mass spectrometry which allow for fragmentation patterns to be used for absolute... Read More
2013-206 – This invention has benefit over other methods since it directly quantitates the mAb without the need for interaction with the antigen. By monitoring tryptic peptides from the unique variable regions of the therapeutic mAb and comparing them to the constant regions of a non-human antibody added as an internal standard, the mAb can be measured. This method is superior to other methods using... Read More
2012-285 – A method to identify if an M-spike contains either a kappa or lambda light chain has been discovered through the use of liquid chromatography tandem mass spectrometry (LC-MS/MS).
2012-139 – In normal healty individuals, the plasma cells produce numerous immunoglobulins each with its own unique protein sequence and hence a unique mass. When examined together, the distribution of the masses forms a Gaussian distribution. Patients whom have plasma cells that overproduce immunoglobulins (M-proteins) are at risk for developing serious diseases such as multiple myeloma. Currently,... Read More
2012-062 – Broad patent claims have issued claiming methods for treating renal cell carcinoma by using SCD1 inhibitors and are available for licensing.
2013-180 – Snail is a protein that, when it is active induces an invasive phenotype in cancer cells. Inactivation of Snail can occur by phosphorylation of its amino acid residue serine 11 (see attached publication). We have generated a phosphosite specific antibody that targets the protein Snail, when it is phosphorylated at serine 11. This antibody can be utilized as a research tool, but also allows to... Read More
"FACS-TB" a Novel Laboratory Method and Biomarker for Detection and Stratification of Latent Tuberculosis Infection
2013-109 – Accurate detection of the latent form of tuberculosis (TB) infection remains a major clinical and public health problem worldwide, which in the United States, disproportionally affects minorities, foreign-born individuals and patients with weak immune defenses (e.g. patients with HIV infection andlor on immunosuppressive medications). We designed and validated a new method that detects... Read More
2013-100 – Background: This invention creates a digital dash board which is integrated into a monitor within any invasive laboratory. The digital dash board displays real-time information on the patient during the procedure. The dash board also can be used to assess the risk of the patient and safety assessment prior to the procedure.
2013-081 – Magnetic resonance imaging (MRI) is widely used to diagnostically investigate the human body. However, unlike other medical imaging modalities (e.g., X-ray CT), MRI data is not explicitly quantitative - pixel values do not directly represent physiological information. There is strong clinical interest in transforming MRI into a quantitative modality, and to measure quantities such as flow,... Read More
2012-253 – Frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) are devastating neurodegenerative diseases. FTLD results from the degeneration of the frontal and temporal lobes of the brain, and encompasses a group of disorders distinguished by abnormalities in behavior, language and personalityl. ALS is characterized by the degeneration of motor neurons, resulting in muscle... Read More
2012-224 – Increase in bladder stiffness could be associated with various pathophysiologic conditions. We introduce Ultrasound Bladder Vibrometry (UBV), a novel method for rapid and noninvasive measurement of bladder wall viscoelasticity. UBV uses acoustic radiation force to excite mechanical waves in the bladder wall and track the motion using ultrasound pulse-echo techniques. Fourier domain analysis... Read More
2012-221 – Ultrasound radiation force is used to create propagating waves in soft tissue or other soft materials. The wave propagation is measured using pulse-echo ultrasound methods. We use a two-dimensional Fourier transform method to obtain the Fourier-space (k-space) with the coordinates of frequency (f) and wave number (k). The wave velocity © at each frequency is calculated by finding the... Read More
2012-141 – Carpal tunnel syndrome (CTS) is a common problem with an estimated lifetime risk of 10%, a prevalence of about 3%, and a large economic burden of more than $1 billion annually for direct medical costs. It has been commonly recognized that carpal tunnel pressure (CTP) increases in CTS patients. However, measurement of CTP is invasive and not reliable due to technical difficulties. Although CTP... Read More
2012-134 – Shear wave produced by a focused ultrasound beam is used to evaluate tissue visco-elasticity, which are sensitive biomarkers of pathology. Shear waves thus produced are weak and attenuate quickly when propagating away from the push origin. We have proposed a method called CUSE where multiple unfocused push beams spaced out like a comb are used for shear wave production. Every pixel under... Read More
2012-129 – A method to quantify tissue viscoelastic properties in a model-independent way by estimating the complex shear modulus from creep-recovery response and shear wave propagation speed by ultrasound acoustic radiation force. This method uses a formula that converts creep-recovery response in time to frequency domain complex modulus. The shear wave speed is used to calibrate the complex modulus... Read More
2012-112 – We have identified abnormalities in the B cell compartment in the circulation of patients with ALS. This abnormality could be used to develop a test to measure the prognosis of patients with ALS or to diagnose patients with different forms of the disease. Additionally, the involvement of B cells in the pathology of ALS will lead treatments that may ameliorate the disease or its symptoms.
2012-110 – Currently, cancerous pigmented lesions, i.e. malignant melanoma, are diagnosed based on morphological features such as cell size and the overall architecture of the lesion under a microscope. Risk of metastasis is primarily assessed by the depth of invasion of morphologically atypical cells into the skin (so-called Breslow depth), which can be misleading and often triggers unnecessary... Read More
2012-083 – Coronary CT angiography (cCTA) is used to noninvasively look at the arteries that supply the heart muscle with blood, and diagnose (or rule out) blocked arteries, which are the main cause of heart attacks. cCTA is performed with either prospective or retrospective ECG gating. Irrespective of which variant is used, images are reconstructed with projection data corresponding to a partial scan... Read More
2012-073 – Erectile dysfunction (ED) is estimated to affect 20-30% of men between the ages of 40-80 years. In cases of medication-resistant ED, surgical treatment, and especially penile prosthesis implantation is the standard of care. Complications of surgery can include neurovascular and urethral injury, and other tissue damage that can contribute to sub-optimal outcomes. A Mayo Clinic investigator... Read More
2012-057 – Shear wave is used to evaluate tissue visco-elasticity, which are sensitive biomarkers of pathology. In order to obtain a 2D ultrasound elastography, an ultrafast imager with a FRAME rate of several kHz is required to capture the fast moving shear waves. This is not feasible with traditional ultrasound imagers with a frame rate of less than 100 Hz where 2D images are formed LINE BY LINE. ... Read More
A Novel Method to Identify Antigens Which Act Co-Operatively To Treat Established Tumors Using Viral-Expressed cDNA Libraries
2012-049 – We describe a novel technology to define new repertoires of tumor antigen(s) which work alone or in combination to generate anti tumor immune responses. Definition of arrays of antigens which co-operate in vivo to cure established tumors will inform future strategies for novel clinical vaccines through the use of vesicular stomatis virus with cDNA libraries constructed with selected, relevant... Read More
Nuclear Reprogramming Through Oxygen-Independent Metabotype Purges Dysfunctional Mitochondrial Heteroplasmy
2012-007 – Mitochondrial disease is inherited through maternal transmission of mutated mitochondrial DNA (mtDNA) with disease phenotypes determined by the unpredictable mixture of mutant and wild-type mtDNA. Mitochondrial heteroplasmy is dependent upon stochastic segregation of mtDNA into discrete units during early embryogenesis as mtDNA replication is shut off during blastomere expansion. Since... Read More
2011-274 – The invention uses ultrasound to measure the nonlinear mechanical properties of an object including those of biological tissues. This information can be used to detect abnormalities in tissues.
2011-271 – We identified a novel translocation of TP63 gene which encodes p63 protein. The translocation leads to overexpression of a dominant negative TP63 isoform. Dominant negative TP63 isoforms lead to inactivation of p53, the most important tumor suppressor known. The translocation can be useful for diagnosis and subclassification of certain peripheral T cell lymphomas, B-cell lymphomas... Read More
2011-249 – TB-ELISPOT is an optimized Interferon-gamma release assay (IGRA) that accurately detects latent tuberculosis infection (LTBI). This novel TB-ELISPOT method incorporate research-grade technology to enhance antigen-specific activation of T-cells by utilizing co-stimulatory antibodies and best antigen stimulation conditions (48 hrs) in a multiparametric platform that compare specific M.... Read More
2011-245 – Immune responses directed toward many cancers are characterized by targeted cell-killing activities mediated by cytotoxic T cells (a.k.a. Thl responses). However, certain tumors such as bladder cancer, instead appear to elicit immune responses that are traditionally linked with allergies (a.k.a. Th2 responses). These immune responses also include the tissue recruitment of rare white blood... Read More
Individualized CT Scan Protocols for Scanning with Either Lower Radiation Dose or Lower IV Contrast Dose
2011-229 – We developed a technique for creating individualized CT protocols that allow patients to be scanned with either lower radiation dose or lower intravenous contrast dose whilst maintaining iodine contrast-to-noise ratio and diagnostic image quality.
2011-224 – A method to quantify tissue mechanical properties in a model-independent way by estimating complex elastic modulus from time-dependant creep response induced by acoustic radiation force. This method uses a formula that converts time-domain creep compliance to frequency domain complex modulus. Then Shearwave Dispersion Ultrasound Vibrometry (SDUV) is used to calibrate the complex modulus so... Read More
2011-210 – Multiple short-duration ultrasound push pulses are used to deform tissue. The duration and PRF (Pulse Repetition Frequency) of these push pulses are compatible with current ultrasound scanners because these pulses are comparable to Doppler pulses. The collective effect from many push pulses generates shear waves of high amplitude for elasticity imaging. Two shear waves are produced: one at... Read More
2011-184 – Methods and Materials for Assessing Responsiveness PARP Inhibitors and Platinating Agents Methods and materials have been developed for assessing responsiveness to PARP inhibitors and platinating agents by using levels of non-homogous end-joining (NHEI) pathway members to determine if cancer cells that are homologous recombination (hr) - deficient are likely to be susceptible or resistant... Read More
2011-178 – Radiation dose from CT scanning is an increasing health concern, but lowering radiation dose alone generally produces a noisier image and may degrade diagnostic performance. Non-local means (NLM) denoising has become widely accepted as a very effective denoising tool in the image processing community, and has yielded very promising results in lung and abdominal CT. However, NLM requires an... Read More
2011-130 – The calibration data for an accelerated contrast-enhanced MRA acquisition are acquired in the short time after contrast injection and before contrast arrival. This eliminates the separate acquisition for calibration data.
Mutations in the KCND3-Encoded Kv4.3 Potassium Ion Channel and Use in Diagnostic Methodologies for the Detection of Sudden Death-Predisposing Cardiac Channelopathies
2011-122 – The present invention details mutations in the KCND3-encoded Kv4.3 potassium ion channel that are associated with sudden death predisposing genetic conditions such as Brugada syndrome (BrS) and long QT syndrome (LQTS) and the mechanism by which at risk individuals can be screend for potentially life threatening mutation isn this gene. This invention is based on the that mutations within the... Read More
2011-114 – In dynamic time series imaging, noise varies from image to image, but the underlying structure (although it can vary somewhat) is generally preserved. Techniques that take advantage of this are capable of efficiently denoising such data sets. In this invention, time series images are decomposed into overlapping subblocks of size NxN, with each subblock sampled T times in the time dimension.... Read More
2011-108 – Parallel Imaging is a widely used strategy for accelerating MRI acquisitions. Auto-calibrated coil-by-coil methods such as GRAPPA and ARC have become increasingly popular since they do not require a separate calibration scan (as do SENSE and ASSET) nor explicit estimation of coil sensitivity profiles, making them attractive for time-limited and dynamic applications like cardiac imaging.... Read More
Method for Reconstructing Dynamic Resonance Imaging Series From Limited Measurements Using Matrix Rank Constraints
2011-106 – This disclosure allows for image series to be reconstructed from only a subset of the data normally required to form the image series, and correspondingly for image acquisition time to be reduced. As demonstrated, the proposed reconstruction mechanism can provide improved temporal fidelity compared to other rank-based MRI series reconstruction methods.
2011-026 – Propagation of shear wave (e.g., frequency dependent propagation speed and attenuation) in tissues is determined by mechanical properties of tissues. In ultrasound elasticity imaging, focused ultrasound beams are used to generate and detect shear waves in tissues. The 3D shape of the ultrasound beam can artificially increase measured shear wave speed in the transducer near field and... Read More

domain: biology


JEFFERSON CITY, Tenn. – The Carson-Newman women's tennis team won their fourth straight match against Tennessee Wesleyan with an 8-1 victory on Friday afternoon, it was the Eagles first win of the 2017 season.
The Carson-Newman (1-3) women's tennis team took two out of three matches in doubles play on Friday afternoon. The No.1 doubles team of Ali Harris (Crossville, Tenn.) and Jill Corsato-Owsianka (Germany) shutout Tennessee Wesleyan (3-2) 8-0. The all-freshman tandem of Alisa Liashova (Ukraine) and Klara Vuckovic (Germany) won 8-1 at No.2 doubles. Lindy Tatum (Henderson, Tenn.) and Sydney Ledington (Corbin, Ky.) lost in the finals doubles match of the afternoon 8-5.
Harris and Corsato-Owsianka carried their momentum into singles play, each picking up a straight sets victory over the Bulldogs. Harris won her first match of the season at No.1 singles (6-1, 6-2), while Corsato-Owsianka picked up her second victory of the season at the No.2 singles position (6-2, 6-0).
The Eagles Freshman trio of Liashova, Vukovic, and Tatum excelled in their first collegiate home match. Liashova won in straight sets over Haruka Hirata 6-4, 6-4. Vukovic easily defeated Wendi Watson at the No.4 singles position 6-2, 6-2. Tatum defeated Arianna Pelletti 6-1, 6-3 at the No.5 singles position giving the freshman trio a combined 3-0 record on the day.
Ledington rounded things out for the women's team winning in straight sets 6-2, 6-3 over Rachel Walker at the No.6 singles position.
The women's tennis team will have a quick turnaround and begin South Atlantic Conference play on Sunday afternoon against Anderson University at 2 p.m.


text:
really want the finished art or
I chalk it up to experience. I do ask for $25 earnest money (nonrefundable)
to cover the cost of my supplies.
what you want.
I'll quote you a reasonable price*!"
*Once we agree on the price
I will invoice you by email for the earnest money, then finally for the approved
finished art. You can pay in the ways listed below or by personal check &
Memorial and Heirloom
"Through the years,
your decendents will appreciate your thoughtfulness because you turned
an old faded photograph into a family heirloom."
on an image above to view the larger version of the portrait.

domain: artistic


text:
Denti Strength is a dental health formula that reduces the number of bacteria in the mouth, helping users to protect their teeth and gums from damage.
Product Name: Denti Strength
Official Website: CLICK HERE
Denti Strength Review
When you have low dental strength, you are concerned about pain and have to deal with a disparaging appearance when you are in public. Oral problems are becoming more widespread as a result of poor eating habits. Another important factor to consider is what you do to improve your dental health. Brushing alone will not protect your teeth from dental problems. Other hygiene practises recommended by dentists can also be found. There is still a possibility of tooth and gum disease developing. There are a plethora of dental supplements on the market, but none of them are effective in protecting the teeth and addressing the fundamental cause of the problem. As a result, for a healthy boost, this review introduces “Denti Strength,” a new supplement from PhytAge Laboratories. The following review will focus on the Denti Strength supplement and will provide you with a thorough description of the product.
Despite the fact that there are numerous recommended medicines and pharmaceuticals available, they may only provide short relief. However, the review offers a 100 percent natural alternative to medicines, dental implants, and surgery for treating teeth and gum disorders. The review is about the previously stated Denti Strength supplement, which helps to reinforce your mouth with the minerals it needs.
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domain: medical


text:
Unlawful decisions on removing cycle lanes – what does it all mean?
Of course, I expected the council to present the facts in the most favourable or least damaging way it could, but even I was surprised to see its spokesman claiming that it only “settled the case so as to avoid further costs to the public purse”, that it had “no further implications for other proposals or schemes”, that somehow this was of “no significance other than to resolve litigation”, and it merely reflected an omission to “include in a council report a clearer account of government guidance and its effect before taking the decision”.
Mandy Rice-Davies Applies
Well, he would say that wouldn’t he, and it seems that ‘Mandy Rice-Davies Applies’ - the litmus test to assess whether people in particular circumstances will deny the facts to avoid immediate difficulties .
Perhaps I’d better go through some facts, starting with the actual court order.
Ignoring the statutory guidance
As the order shows, Cycling UK’s claim was upheld because the council failed to have regard to statutory guidance issued under section 18(1) of the Traffic Management Act 2004, did not act in accordance with it, or give clear and cogent reasons for departing from it. Highway authorities have a ‘network management duty’ under that Act, which also obliges them to comply with statutory guidance when performing their network management duties.
The ‘reasons for decision’ section of the order also specifically states that when making the decision to remove the cycle lane, the council unlawfully failed to take the statutory guidance into account. That's not pointing to some technical omission to mention it in a report, as the spokesman claims - but to the fact that the council just didn’t take it into account at all.
Protecting the public purse
The council’s claim that it settled this case to avoid further costs and protect the public purse also needs to be considered with an eye to the gloss it's putting on its own unlawful actions.
Cycling UK commenced legal proceedings against the council back in February 2021. The council then spent over 11 months defending the claim, incurring costs, and maintaining that it acted lawfully, before finally admitting it hadn't, just days before a two-day final hearing was due to begin.
That’s cost it all of its own legal costs, £25,000 towards our costs, plus all of the management and administrative time and costs involved in year-long litigation, when it could have accepted its mistake before proceedings were even issued, avoiding all of those costs.
The tax-payers of West Sussex can decide whether that’s protecting the public purse.
Nothing to see here
As for the assertion that all of this has “no further implications for other proposals or schemes”, well that’s simply untrue because it already has.
The spokesperson has clearly forgotten that the removal of the cycle lane led to the council being barred from the next round of active travel funding.
Last July, Transport Minister Chris Heaton-Harris wrote to the council explaining that it would not be eligible to apply for government funding for active travel schemes during 2021/22, because “the schemes delivered under tranche 1 of the Emergency Active Travel Fund were not allowed to be fully tested and/or optimised before the schemes were removed” and that “this was not a good use of public money and means that your authority will not be invited to bid for any new capital funding this year.”
So, an order that the council acted unlawfully, serious costs consequences, and implications for future government funding for all transport schemes (not merely active travel schemes) means there's nothing to see here because, as the spokesman added, there’s “no prospect of the cycleway being restored”.
Restoring a temporary lane – or a permanent lane
But if the temporary cycle lane isn’t being restored, what was the point of our litigation?
Well, I’ll come to that, but the first thing to mention is that the spokesman’s comment is carefully worded. Some will read this as an indication that no cycleway will be implemented on Upper Shoreham Road, when what he actually means is that the temporary cycle lane, with plastic cones and bollards, won’t be restored in the interim.
With apologies for a short bit of legalese, but the court proceedings Cycling UK issued involved a judicial review of the council’s decision to remove the lane, in which we asked the court to make a declaration that the council acted unlawfully. If a court makes a declaration of unlawfulness, it then has a discretion to order some form of remedy, which in this case could have included the re-instatement of the temporary cycle lane.
Whilst the outcome of any litigation is uncertain, we were always reasonably confident that we’d secure either a declaration or, however belatedly, an admission from the council that it had acted unlawfully. Getting a discretionary remedy - the re-instatement on the temporary lane - was, however always going to be harder, and a 12-month delay from removal in January 2021 to the final hearing made securing that discretionary remedy less likely.
Increasing space for active travel on Upper Shoreham Road
In the interim, the council had of course repeatedly claimed that it was committed to active travel, and indeed to a long-term scheme on the Upper Shoreham Road. It's published a Transport Plan for West Sussex which states (para 7.16) that the council’s strategy “is to enable local living by making active travel increasingly realistic and attractive for short distance east-west journeys by increasing space for active travel on the important Upper Shoreham Road, A270 and A259 corridors.”
So, twelve months after the lane was removed, and now with the council having admitted that it failed to take into account the guidance, it's committed publicly to increasing space for cycling on the important A270 Upper Shoreham Road. Also, it confirmed within court proceedings that it would have proper regard to the network management duty and any relevant statutory guidance in finalising and implementing a permanent cycleway along that route. Consequently, an order to re-instate the temporary lane was becoming an unlikely outcome.
Of course, what the people who used the cycle lane and the local campaign group Shoreham-By-Cycle really want is a permanent cycle lane. The question for the council is this: when are they going to start delivering on their transport strategy commitments?
Active travel league table
I said I’d come back to the question about why we issued these proceedings if we might not secure the re-instatement of the lane.
Firstly, and dealing purely with the local issue in West Sussex, the practical reality is that however the spokesman tries to spin this, the council has been caught out. It acted unlawfully, that’s cost a chunk of tax-payers' money, and the DfT effectively barred it from the next funding round.
It’s a council on the naughty step now, and the only way off that step is to be bold, stop trying to paint a gloss on what’s happened, and set a timescale for delivery of a permanent cycle lane on Upper Shoreham Road.
Put bluntly, it needs to show that it’s serious about cycling and walking schemes, or it will go straight to the bottom of Active Travel England’s league table, which is likely to impact on wider transport funding from government in future.
Sending a message to other councils
Secondly, this case was never just about West Sussex and one cycle lane.
We don’t have the capacity to challenge every decision councils make which we don’t agree with. But, in the last 18 months, too many councils have removed cycle lanes and other active travel schemes without allowing them time to bed in, without adequate evaluation, and with scant regard to the relevant statutory guidance. The decision in Shoreham was a classic example of this, so we took this case to court to shine a light on this issue, and to send a message to other councils.
Whilst this case has been winding its way through the legal process, it’s gathered significant interest amongst local government lawyers – the people who advise those making the decisions within councils about the potential consequences of failing to follow legal advice or statutory guidance!
In West Sussex, the decision to remove this lane was made by one person. That decision was called into a scrutiny committee, which noted that the scheme had exceeded expectations and that it was questionable why a successful scheme should be removed. They asked the Cabinet Lead to think again, but he ploughed on regardless.
The consequences for the West Sussex Council are a lesson for others to heed when making decisions on active travel schemes – if you ignore the guidance, don’t gather the evidence, and panic the moment anyone complains about a scheme, there are consequences.
Cyclists Defence Fund
Cycling UK can only put matters like this before the courts, and stand up for people who cycle, or might cycle if they felt safer doing so, because we have designated funds in our Cyclists’ Defence Fund (or CDF). We use this to help fight significant legal cases involving cyclists and cycling, and we drew on it to pursue this case.
Although we have recovered £25,000 from the council towards our legal costs, we also need to be in a position to pursue the next important case, and be ready to stand up for cycling and cyclists in the future. Please help us to be ready, by donating to Cycling UK’s Cyclists’ Defence Fund. Your donation will go towards our designated legal fund, set aside as a ‘fighting fund’ for legal action and cases.

domain: politics


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Synopses & Reviews
Find Out More About Trees
1. What happens to water after it reaches the leaves of a tree?"
To find out, you will need:
1 small clear plastic bag
1 leafy twig
1 small piece of string or twist tie
1 empty 8-ounce jar
1 cup of water
1 potted plant
Place the plastic bag around one of the leaves or a cluster of leaves on the twig. Using a small piece of string or a twist tie, carefully tie the bag to the stem of the leaf or cluster of leaves. Fill the jar with one cup of water, and put the twig into the jar. Place the jar on a sunny windowsill. After one day, what do you see in the bag? Check the bag every day for a week, and record what you see on a chart.
Now try this experiment with a potted plant to see if it works in the same way. Carefully tie a plastic bag around one of its leaves or a cluster of leaves, just as you did in the first experiment. Ask an adult to help you place the plant in a sunny spot and water it. Check the bag every day for a week, and record what you see on a chart. How are the results similar to or different from those in the first experiment?
2. How old is your tree?
Trees can live for a very long time. The trees in your backyard or in the park may be as old as you are or they may be as old as your grandpa or grandma - or even older! Some trees can live longer than others. Redwood trees, which grow in northern California can live an average of 600 years. The oldest known redwood was 2,200 years old!
To find the age of a tree, wrap a tape measure around the trunk about three feet above the ground. The distance that you are measuring around the middle of a tree is called the girth. Every inch in the girth equalsabout one year in a tree's growth. How old is your tree? Is it younger or older than you are? By how many years?
Glowing new illustrations adorn this classic "Let's Read and Find Out Science" primer, first published in 1960. Kirkus
A tree is the biggest plant that grows.
Trees can live for a very long time, and they are alive all year long, even when they look dead in winter.
In this newly illustrated book, you will learn how a tree grows and how it gets food and water. You can also find out what happens to water after it travels through a tree's roots, branches, and leaves, and how to figure out a tree's age.
Clyde Robert Bulla's simple and concise text and Stacey Schuett's lush illustrations follow a tree's continuous life cycle through spring, summer, winter, and fall.
A tree is the biggest plant that grows. Trees can live for a very long time, and they are alive all year long, even when they look dead in winter. Clyde Robert Bulla's accessible text and Stacey Schuett's lush, accurate illustrations follow a tree's continuous life cycle through spring, summer, winter, and fall.
This is a Stage 1 Let's-Read-and-Find-Out, which means the book explains simple science concepts for preschoolers and kindergarteners. Let's-Read-And-Find-Out is the winner of the American Association for the Advancement of Science/Subaru Science Books & Films Prize for Outstanding Science Series.
Supports the Common Core Learning Standards and Next Generation Science Standards.
About the Author
Clyde Robert Bulla is the author of over fifty books for children including The Secret Valley
and The Story of Valentines Day
. He has been writing since 1946 when he published his first book, The Donkey Cart.
Mr. Bulla was the first recipient of the Southern California Council on Childrens Literature award for distinguished contribution to the field. He lives in Los Angeles, California.
Stacey Schuett's artwork graces numerous picture books, including the I Can Read Book Forest by Laura Godwin and her own Somewhere in theWorld Right Now, a Reading Rainbow Book. Ms. Schuett lives in Sebastopol, California.


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Our Accepted Proposal:
We are inundated with information daily without request or permission yet we still find time to go to the library and seek out information ourselves. The library is almost a sacred space, a reliquary for the texts our culture considers significant enough to require an embodiment in the printed page, not just an existence as bits of data. In this age of electronic information something still draws us to cradling a book in our hands, this show is an homage to that desire. The pleasure of getting lost in a book.
In addition to displaying paintings based on favorite works and altered books we are requesting permission to take the show into the stacks by tucking small artworks into the shelved books. We feel that this will create a much more interesting, expansive and intimate show. The huge popularity of Griffin & Sabine by Nick Bantock points to the fascination that people have with the personal documents of other's lives. Discovering an artwork would allow the reader into a shared relationship with the author and other readers, crossing boundaries between fact and fiction, or history and the present. It would be a wonderful way to make an intimate impact on the viewer/reader as they discover a hidden gem in a book that happened to catch their eye, or even better bring something new in one of their favorite texts.
Some examples of possible planted artworks include:
Portraits of characters in the books
Trading cards of authors with vital stats (like sports trading cards)
To do lists of authors or characters which mirror the narrative in the book.
Fictional correspondence of authors, readers, and/or characters.
We would set up rules regarding the placement of artworks into books in the stacks. First and foremost the items should not damage the book. The artwork should be age appropriate for the books they are placed in. The artist would not hold any expectations that the artwork would be returned - they may be lost, collected, or perhaps enjoy an extended journey with the book. They would all be cataloged and marked with the web site for the show. This web site would provide a place for the audience to comment on their discovery experience and find the locations of the other artworks. If requested all planted artwork could be removed from the stacks at the end of the show.

domain: library


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CrazyTalk Animator is designed to create quality animations with vector and bitmap artwork. It eliminates the need of tedious frame-by frame animation, and allows you to produce animated movies, entertainment, TV commercials, cartoons films, short stories, educational presentations, home videos, games, product demos, websites and more.
GIF animations are made simple - by composing a series of individual poses, in different time frames, you will be able to export animated images for use in web pages, presentations and other video productions.
CrazyTalk Animator offers a high compatibility for video producers to export image sequences with alpha channels, so that virtual characters can be easily immersed into other media. Create flip books by easily exporting a series of images in motion.
To produce an animated comic book, CrazyTalk Animator can quickly turn any artwork into elements for puppetry. You may export your creation as image sequence for comic print or bring your still comic characters to life.
Create eye-popping stereoscopic videos and images, by simply clicking the 'Stereo Vision' output option in the export panel. All projects are layer-based in real Z-depth, which allows users to arrange everything with great 3D stereo results.

domain: design


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Darlington have completed their fifth signing of the month with the capture of veteran goalkeeper Lee Jones from Blackpool.
The 35-year-old has joined on a month's loan, although the transfer could become a permanent one after that if he impresses manager Dave Penney.
Jones is eligible to play in tonight's Johnstone's Paint Trophy Northern area semi-final against Doncaster Rovers, although he may only make the bench.
"Lee is a big imposing goalkeeper who has bags of experience and commands the penalty area," said Penney. "We have needed some back-up for David Stockdale who has done very well under the circumstances and this signing will give me options."
Jones will join fellow newcomers Kevin Burgess, David Wheater and Evan Horwood in the squad that travels to Doncaster but Tim Ryan will not feature at the Keepmoat Stadium as he has already played in the competition for Boston United.
For Penney the trip promises to a highly-charged occasion as it will be his first return to Doncaster since he left the club back in October. Penney led Doncaster back into the Football League and up into League One and is still a popular figure in the town.
He said: "It is very special. It is about three months since I left there after eight great years as a player and a manager.
"I never got to the new ground but it will be nice to go back. I'm looking forward to it and hopefully the players we've brought in can help us to get a result because I want to go there and win.
"It's the semi-final of a cup and we are close to playing in a final which would be great for the club and supporters.
"The closer you get to the final you know it can lead to a good day out."

domain: news


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Declining life expectancies in the US include Gen X and Y Americans, in addition to the older Baby Boomers. But the causes of premature mortality vary by race, gender and ethnicity, according to a new study from Duke University. The researchers examined data from the Centers for Disease Control and Prevention Mortality Multiple Cause Files for the years 1990-2016.
October 7, 2013
December 26, 2018
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“I’ve always been deeply affected by music, so I guess it was inevitable that I would wind up in a band. It wasnt until I discovered prog that my previously tedious piano lessons began to make sense. Ironically, it was at that point that my piano teacher threw me out because I was trying to play in my own way, rather than how it was written down.
As far as im concerned, music has to have craft and thought put in to it to move people, generate a reaction. You can do this in many ways, but my main area within Strangefish is melody and harmony (and the occassional dischord). I’m always chasing that elusive sequence of chords that make your spine turn to jelly. When you discover one it’s the biggest thrill there is!”
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Dr Jennifer Martin is a leading clinical pharmacologist. She is the Chair of the discipline of Clinical Pharmacology in the School of Medicine and Public Health at the University of Newcastle and a senior staff specialist in internal medicine at the John Hunter Hospital.
Dr Martin is also Director of the NHMRC-funded Australia Centre for Cannabinoid Clinical and Research Excellence (ACRE), Australia’s first federally-funded research centre in medicinal cannabinoids to ensure quality and safety in the implementation of medicinal cannabis use in the community.
She is also lead chief investigator on a $1.96 million Cancer Council NSW pathways grant to develop a personalised chemotherapy dosing system for cancer patients, and more than $3m in funding for medicinal cannabis research as part of NSW Health’s Clinical Cannabis Medicines Program.
In addition, Professor Martin is part of Australia’s first medical cannabis trial to produce world-class pharmacokinetic analysis and sophisticated modelling to inform drug dosage and frequency of administration.
Based at the Hunter Medical Research Institute, the former Rhodes Scholar leads a team of pharmacy and medicine experts together with pharmacoepidemiologists and pharmacoeconomists.


Looking to recruit a dynamic governing board member?
The Governance Board Program recruits quality community members looking to serve and make a difference and match them with charter schools in their community.
Services Provided to Schools
- We will meet with you to determine your Board needs.
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- We then work to match you with a member of your community that is ready to serve on your board.
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Who Can Participate?
Newly approved charter schools: Schools who have acquired their charter contract and are within their first five years of operations
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Alright, who got hammered and stole this giant duck in the middle of the night?
“To the person or persons who are responsible, it might be best to get ducky back to where he belongs,” wrote the Hunterdon County (NJ) Crime Stoppers on their official page.
The group is referring to a 5-foot 4-inch tall duck that was last seen on Sunday during the town’s annual rubber duck race. Clinton Guild President Diane Crisman-Race said officials believed the duck went missing “sometime between 10pm Sunday and 8am Monday.”
Crisman-Race maintained that the duck was likely stolen, as they were able to determine that the duck did not float away or sink to the bottom of the pond.
“We went to the top of the art museum and looked into the river,” she said. “The water’s clear enough to see through, and it’s not there.”
The Hunterdon County Crime Stoppers are offering a $250 reward for the duck’s return.


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Marriage between people who have previously lived in the same household, or who still do live in the same household and where one has been treated by the other as a child or parent, will be prohibited, according to a key amendment to the Anglican marriage canon.
The amendment was given first reading at General Synod in July. (Before the amendment can be officially enacted, it must pass second reading at General Synod 2004.)
The amendment arose when synod delegates who were concerned about coercion between members of blended families, spoke out during the debate concerning proposed changes to the marriage canon.
Synod also agreed to adopt the federal government’s rule forbidding marriage within blood or adoptive relationships, replacing the “Table of Kindred and Affinity” in the Book of Common Prayer.

domain: law


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Autistic Disorder is what comes to mind when most envision someone with autism. Significant language delays, unusual interests, and social and communication challenges are common. Many also have intellectual disability.
See all 100 lessons at GrowingUpAutistic.com
Contact Lonnie about article reprints. Please specify article you wish to reprint.
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We are a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for us to earn fees by linking to Amazon.com and affiliated sites.

domain: psychology


FIBARO Roller Shutter 3 is a smart home module enabling easy management of electric blinds, curtains, awnings, gates and other devices driven by AC motors.
Calibration of the module makes it possible to set up the roller blinds precisely, and in case of shades, precise control of the lamels. Measuring energy consumption and active power is also one of the smart device built-in features.
|Product Info URL|
921.4 MHz ANZ


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Plastic Free Seas, a Hong Kong-based environmental charity, is calling for an investigation into the source of the black granule microplastics which have been washing up onto the beach in Discovery Bay since late July. A cleanup operation resulted in the recovery of over two tons of the black crumb-like material, as well as other debris.
The NGO has expressed their frustrations with the lack of a coordinated emergency response and investigation by the Environmental Protection Department (EPD) and other departments in Hong Kong. It says that after a 2012 incident in which 150 tons of plastic pellets fell into the ocean from a container ship, as well as a palm oil spill in 2017, this need is ever more important.
While Clean Shorelines, an Interdepartmental Working Group, was set up after the pellet spill, the group focuses on cleanup rather than investigation, penalties and incident prevention.
From an internal investigation, Plastic Free Seas found that the microplastics material appears to be rubber infill used in AstroTurf, similar to that used on the North Plaza pitch in Discovery Bay. Infill from the pitch has been seen in and around storm drains which surround the pitch.
Dana Winograd, director of operations at Plastic Free Seas, says, “Even with the obvious and significant amounts of infill which can be seen in drains less than 200m away from the water’s edge, there is still corporate denial of any responsibility for the problem and there has been no attempt to even remove the infill from the drains to prevent further pollution.”
The rubber crumbs collected by the Plastic Free Seas team (Source: provided by Plastic Free Seas).
This infill is typically made from ground up tyres, from which chemicals and heavy metals make their way into seawater.
Winograd says, “In the world of plastic marine pollution, there is often too much focus on cleanup and managing plastic pollution and not enough real action taken on prevention. A government investigation is slow and ongoing, and only as a result of a significant push from Plastic Free Seas. We need the government to find out the source of this problem, ensure that the ongoing pollution problem at this pitch is solved, and also to assess all the synthetic pitches in Hong Kong and mandate best practices for management to ensure the rubber crumb infill does not continue to pollute our seas and waterways.”
More broadly, PFS has also urged the government for more transparency and communication with supporting NGOs.
This article comes from the frontline activities of Plastic Free Seas, whose mission is to reduce plastic pollution in Hong Kong and beyond through education and action.
About Plastic Free Seas
Plastic Free Seas is a Hong Kong-based environmental charity focused on changing the way we all view and use plastics in society today, through education and action campaigns. Learn more at www.plasticfreeseas.org.


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Fire Cider is a traditional folk remedy for cold and flu season. It's pungent and sweet vinegar extract of powerful immune-boosting, anti-inflammatory, anti-viral and circulatory herbs and vegetables. It is great support for digestive tract because it stimulates digestion. All pungent foods, such as garlic, ginger, horseradish, hot peppers and chilies are excellent for all lung related problems. This food like medicine helps break and move mucus, thus soothing a throat and calming a cough.
Fire Cider is an excellent food-like medicine that can be added to broths, salad dressings, sauces for added flavor and nutrients.*
2 oz / 4 oz glass bottle.
How to use:
Take 1 tsp to 1 tbsp with some warm water, tea or in cooking.
Shake well before each use. Sedimentation that occurs is normal. Keep refrigerated.
Apple Cider Vinegar (unfiltered), Horseradish, Onion, Ginger, Garlic, Jalapeño, Turmeric, Reishi, Orange Peel, Bee Pollen, Honey.
*These statements have not been evaluated by the FDA. This product does not intend to treat, diagnose, cure, or prevent any disease. If you’re pregnant, breastfeeding, or on any medications, please consult with a qualified health professional before beginning any new herbal products.


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The Weeknd has announced his brand new album Starboy, and he's already treated us to the title track.
The Canadian singer revealed news of his upcoming record on Twitter, and later dropped the new single shortly after, which features the legendary Daft Punk.
The new single, also named Starboy, is a moody, mellow offering with the attention-grabbing lyric "I'm a mother f***in' Starboy".
The Weeknd's last album Beauty Behind The Madness became his first Number 1 album in the UK back in 2015 and spawned the Top 3 single Can't Feel My Face. View The Weeknd's complete Official UK singles and albums chart history here.
Starboy is also Daft Punk's first new material in three years since they released their million-selling smash hit Get Lucky and their Number 1 album Random Access Memories.

domain: entertainment


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domain: finance


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Retitling a financial or bank account to your Trust ensures that the account is distributed under the terms of your Trust.
What is the benefit to transferring a financial account to my Trust?
The main benefit is that the account will be distributed according to the terms of your Trust. This means that any conditions you've listed in the Trust will apply to the Beneficiaries also listed in the Trust. Another benefit is that if something happens to your primary (first) Beneficiary, you're able to include backup Beneficiaries that you'd like the account to be distributed to.
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School system considers COVID testing options
HAMLET — The Richmond County School Board has unanimously approved a potential plan for future COVID-19 testing in the school system.
Director of Student Services Dr Wendy Jordan said they were exploring and preparing for potential testing options. RCS officials have been in contact with Raleigh-based testing provider MAKO Medical Laboratories, which the County of Scotland currently uses for its testing services.
“It can help students, families and us,” Jordan said. “It’s an opportunity that we think would be good to take. We’re not obligated to anything yet.
MAKO screening would catch COVID-positive students early to contain the spread. Parents would need to register for their child to be tested – students would not automatically be registered.
There would be once a week a random sampling of classes within the K-12 population in various schools. Not all students are tested weekly. Sports teams at the college and high school levels would also be checked.
MAKO would report any positive test to the local health department, the student’s school, and the student’s family. Vaccinated and unvaccinated people would be tested since the school system does not have access to a student’s vaccination status.
The North Carolina Department of Health and Human Services is the funding source for testing.
“[NCDHHS] would provide money to our district for staff to help with contact tracing, notification of families [and supplies]”Jordan said.
There is no minimum RCS student attendance requirement to hire staff who would perform COVID testing. Jordan said that, for example, even if 10% of RCS students enroll, they would still be able to hire the staff needed to perform the tests.
Council member Joe Richardson asked how long the tests would take at each school. Jordan replied that he had been told that testing an entire classroom could be done in 10-15 minutes.
The county of Scotland does not carry out screening tests, but diagnostic tests, Jordan said. They only test symptomatic students and do their own testing without hiring MAKO staff. The county of Scotland is simply supplied by MAKO.
Now that the board has approved the plan, Jordan said he can consider starting to hire and making the registration form available to parents.
Positive test rates look ‘encouraging’
“The cases continued to drop,” Jordan said. “Children don’t get [COVID] at school. We hope this will continue as we enter cold and flu season. »
On October 11, there were 12 positive student cases in the RCS school system. Since October 11, the highest single-day number of positive cases was six, which was recorded on three different days.
During the same period, the highest number of positive cases in a single day for staff was two. For most days since October 11, no personnel cases have been reported.
In August, 43 students tested positive over 16 school days, for a total percentage of 0.6% of students in RCS. In September, 204 students tested positive over 30 school days, for a total percentage of 3.1%.
“[September] that’s when the Delta variant was rampant,” Jordan said. “We’re in a much better place for October.”
In October, 77 students tested positive over 31 school days, for a total percentage of 1.2%.
Council approves mask-wearing for December
“I recommend that we continue to require a universal mask for all K-12 students, staff, and visitors inside schools or school facilities, and when arriving on school transportation” , said the superintendent, Dr. Jeff Maples.
The motion was approved unanimously.
To support the Richmond County Daily Journal, subscribe at https://www.yourdailyjournal.com/subscribe or 910-817-3111.
Contact Matthew Sasser at 910-817-2671 or [email protected]


Cocaine can be delivered quicker than a pizza in England and Scotland, according to a global drugs survey.
Some 36.8% of people surveyed in England said they could get cocaine within 30 minutes, and 37.4% in Scotland, placing them fifth and sixth in the world rankings.
This compares with 12.2% of people in England and 19.8% in Scotland who said they could get a pizza delivered in this time.
The 2018 Global Drug Survey questioned 130,000 drug users across 44 countries, including more than 5,000 in the UK, about recreational drug use and its impact on health.
The report said: “With many cities covered with CCTV cameras, traditional street dealing is becoming less attractive to many suppliers and consumers."
"It’s not surprising that the next customer service upgrade was going to be the growth of sophisticated and rapid drug delivery services in many of our big cities.”
What else did the report find?
Drug users in England were found to consume the second highest amount of cocaine in a single session (0.7g), beaten only by Scotland globally.
There is a lack of awareness of the health risks associated with drinking alcohol. A fifth of the 3,600 English people surveyed did not believe the warning that most people get little or no health benefit from moderate alcohol use.
9% of people in England did not believe that alcohol consumption is directly linked to cancer, while almost two thirds (65%) of women under the age of 25 were unaware of the risks.


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By Stevon Marshall and Miriam Raftery
June 14, 2014 (San Diego)—Two Democratic Council members, Myrtle Cole and David Alvarez, won their races outright in districts 4 and 8, with over 50% of the vote in recent primary, so they won’t have to vie in a run-off race in November. Republican Lori Zapf, a Councilwoman who had to run in a different district due to reapportionment, also won her district 2 race with over 50%.
But in district 6, Republican Chris Cate will face off against Democrat Carol Kim in the fall. If Cate wins, Republicans would narrow Democrats’ balance of power on the Council to a slim one-vote majority.
With all precincts counted and only absentee and provisional ballots remaining, Zapf leads in District 2: with 54% of the votes, while her opponents Sarah Boot, Mark Schwartz, and Jim Morrison, earned 38%, 5%, and 4%, rounded dto nearest percentage point.
As for District No. 4, Myrtle Cole won with 57%, while her opponents, Bruce Williams managed 19%, Blanca Lopez Brown took 15%, and Tony Villafranca 8%.
District No.6 had closer results compared to the other races with Chris Cate taking home over 47%, while Carol Kim took 31%, Mitz Lee 13%, Jane Glasson 5%, and De Le 4%.
And lastly, District No. 8 resulted in David Alvarez earning75%, while Lincoln Pickard managed 25% of the votes.
The Cate-Kim matchup in November will be one we’ll be monitoring closely.
This is Stevon Marshall with East County Magazine on KNSJ 89.1 FM Descanso.