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COPD: The statistics
- 14.5% or one in seven Australians 40 years or over have airflow limitation of their lungs. 1
- This figure increases to 29.2% in Australians 75 years or over. 1
- 7.5% of Australians 40 or over have COPD that has progressed sufficiently to where symptoms may already be present and affecting daily life. Half of these people will not know they have it.1
- COPD is the second leading cause of avoidable hospital admissions.2
- Despite falling death rates, COPD is still a leading cause of death and disease burden after heart disease, stroke and cancer.3
- Currently, there is no cure for COPD, there are things people can do to breathe easier, keep out of hospital and improve their quality of life.4
- COPD is preventable and treatable.4
What is COPD?
- Chronic Obstructive Pulmonary Disease (COPD) is a long-term disease of the lungs which causes shortness of breath. While COPD currently has no cure, there are things that people can do to breathe easier, keep out of hospital and improve their quality of life.4
- COPD is an umbrella term that includes emphysema, chronic bronchitis and chronic asthma which isn’t fully reversible.
- COPD is usually characterised by:
- Shortness of breath
- A repetitive cough with phlegm / mucus most days
- History of cigarette smoking or exposure to other environmental pollutants (smokes and fumes) or industrial dust
How does a person with COPD feel?
Symptoms for an individual with COPD tend to creep up gradually. Breathlessness may lead those with the condition to cut back on physical activities. This gradual decline continues until simple daily activities like showering, dressing or making a cup of tea, become almost impossible. Depression and anxiety often affect those with COPD.
What Causes COPD?
- In the western world, cigarette smoking is the single largest cause of COPD.4 However, despite being the highest risk group for COPD, regular smokers are less likely than the rest of the population to consider themselves at risk of developing COPD.5
- Some 20% of COPD occurs in never smokers6.
- Other known risk factors are passive smoking, especially during infancy when the lungs are still developing, exposure to environmental agents, including indoor and outdoor air pollutants and occupational dusts and chemicals.4
- Women may be at greater risk than men of COPD from exposures at work and are more susceptible to COPD due to smaller lungs and airways and more sensitive airways.7
- Chronic asthma may evolve into COPD in later life, especially in those who have smoked and when appropriate medications have not been taken properly.4
Prevalence of COPD
- Lung Foundation Australia estimates that approximately over 1.45 million Australians have some form of COPD.8 This represents approximately one in seven Australians over 40.1
- Of those with COPD currently, Lung Foundation Australia estimates that over 750,000 Australians1,8 have COPD that has progressed to a stage at which symptoms, such as breathlessness may already be present and affecting their daily lives. Half of these people do not have a doctor’s diagnosis of COPD and are therefore not taking the important steps to slow down the progression of the disease.1
- Nearly 700,000 Australians1,8 have a mild form of COPD where symptoms may not yet be present. Many of these will go on to develop more severe COPD.
- People who unknowingly have COPD may mistake their symptoms as signs of ageing, lack of fitness or asthma – a simple lung function test called spirometry from a GP can diagnose COPD.
The Burden of COPD
- In Australia, despite falling death rates, COPD is still a leading cause of death and disease burden after heart disease, stroke and cancer3.
- COPD is a significant cause of death in Australia.
- COPD is the second leading cause of avoidable hospital admissions in Australia.2
- In 2008, the total economic impact of COPD was estimated to be $98.2 billion of which $8.8 billion was attributed to financial costs and $89.4 billion to the loss of wellbeing.10
- Of the financial costs ($8.8 billion), a large proportion is due to the loss of productivity due to COPD, ie lower employment, absenteeism and the workplace impact of premature death of Australians with COPD.10
- The direct cost to the Australian health care system is estimated to be $900 million with hospital use contributing the largest share of health spending ($473 million).10
- In addition to the above costs on the public and private sector purse, there are the costs that are harder to quantify – those of lost wellbeing as a result of COPD. These are estimated to be some $90 billion.10
- In terms of overall costs, COPD is more costly per case than cardiovascular disease, osteoporosis or arthritis.10
COPD diagnosis and treatment
- COPD is preventable and treatable4.
- While there is no cure for COPD, there is strong medical evidence to show that early diagnosis, combined with disease management programs at the early stages of the disease could reduce the burden of COPD, improving quality of life, slowing disease progression, reducing mortality and keeping people out of hospital.4
- Lower costs and burden of disease can result if diagnosis is achieved early and optimally assessed, especially as treatment can reduce exacerbations. 13-18
The key aims of COPD treatment are to reduce symptoms, improve quality of life, increase the capacity for exercise and ultimately, keep people well and out of hospital. There are a number of steps people with COPD can take to breathe easier and improve their quality of life.
- Stop smoking – helps improve symptoms and slow down the rate the disease progresses.4,14
- Inhaled medicines – reduce symptoms, improve quality of life, reduce activity limitation and prevent exacerbations associated with hospital admissions. Check inhaler device regularly. 4
- Pulmonary rehabilitation –reduces breathlessness, fatigue, anxiety and depression, improves exercise capacity, emotional function and health-related quality of life and enhances patients’ sense of control over their condition. Pulmonary rehabilitation reduces hospitalisation and has been shown to be cost-effective.4
- Regular immunisations against influenza and pneumonia.4
- Support groups/services – as COPD worsens and patients feel less able to carry on their normal activities, patients become increasingly isolated. Support groups/services can help meet the emotional and social needs of people with the condition, helping them realise that they are not alone.
- Oxygen therapy – helps those people with advanced lung disease who are unable to absorb sufficient oxygen to supply their vital organs.4
- People older than 35 with a history of cigarette smoking should speak with their GP if they do any of the following:
- Cough several times most days
- Bring up phlegm or mucus most days
- Are short of breath compared with others their age
For further information please contact:
Kirsten Phillips, Director COPD National Program, Lung Foundation Australia
- Toelle B, Xuan W, Bird T, Abramson M, Burton D, Hunter M, Johns D, Maguire G, Wood-Baker R, Marks G. COPD in the Australian burden of lung disease (BOLD) study. Respirology 2011;16 (Suppl 1):12
- Page A, Abrose S, Glover J et al. Atlas of Avoidable Hospitalisations in Australia: ambulatory care-sensitive conditions. Adelaide PHIDU. University of Adelaide. 2007
- AIHW 2012. Australia’s health 2012. Australia’s health no. 13. Cat. no. AUS 156. Canberra: AIHW.
- McKenzie DK, Frith PA, Burdon et al on behalf of Lung Foundation Australia. The COPDX Plan: Australian and New Zealand Guidelines for the Management of Chronic Obstructive Pulmonary Disease 2008, found at www.copdx.org.au
- Newspoll Market Research. Conducted by telephone in October 2007 among a representative sample of 688 adults aged 45 and over across Australia.
- Lamprecht B et al, COPD in Never Smokers: Results From the Population-Based Burden of Obstructive Lung Disease Study. Chest 2011; 139; 752-763; Prepublished online Septemberr 30, 2010; DOI 10.1378/chest.10-1253.
- Petty T. The Rising Epidemic of COPD in Women: Why women are more susceptible; how treatment should differ. Women’s Health in Primary Care Dec 1999;2(12)
- Based on ABS census data — CData Online 2006 Census, Australian population over 40.
- AIHW 2010. Australia’s Health 2010, found at http://www.aihw.gov.au/publication-detail/?id=6442468376.
- Access Economics. Economic impact of COPD and cost effective solutions. 2008.
- Buist AS, McBurnie MA, Vollmer WM et al. International variation in the prevalence of COPD (The BOLD Study): a population-based prevalence study. Lancet 1 September 2007; 370: 741-750
- Crockett AJ, Cranston JM, Moss JR. Economic Case Statement. Chronic Obstructive Pulmonary Disease. Australian Lung Foundation, Sept 2002
- Fletcher C, Peto R. The natural history of chronic airflow obstruction. B Med J 1977;1:1645-1648
- Abramson M et al. Managing chronic obstructive pulmonary disease. Aust Prescr 2007;30:64-7. Available at: https://www.nps.org.au/australian-prescriber/articles/managing-chronic-obstructive-pulmonary-disease
- Lacasse Y, Brosseau L, Milne S et al. Pulmonary rehabilitation for chronic obstructive pulmonary disease. Cochrane Database of Systematic Review. 2001; Issue 4
- Griffiths TL, Phillips CJ, Davies S et al. Cost effectiveness of an outpatient multidisciplinary pulmonary rehabilitation programme. Thorax 2001;56:779-784
- Golmohammadi K, Jacobs P, Sin DD. Economic evaluation of a community-based pulmonary rehabilitation program for chronic obstructive pulmonary disease. Lung 2004;182:187-196
- Australia Centre for Asthma Monitoring 2011. Asthma in Australia 2011. AIHW Series no.4. Cat. No. ACM 22. Canberra: AIHW.
The COPD National Program receives unrestricted sponsorship towards the development of training and resources from the following companies:

domain: health


text:
Missoula Public Library | 301 East Main Missoula MT 59802 | (406) 721-2665 | M-W 10am-9pm | Th-Sa 10am-6pm | Su 1-5pm
Book Chat Bag Reservations
What is a Book Chat Bag?
A Book Chat Bag is a canvas bag filled with at least 10 copies of one title and a discussion guide with book reviews, author information, discussion questions and additional tips and resources for book groups.
How do I reserve a Book Chat Bag?
Choose a title from our list of available Book Chat Bags. Stop in at the MPL Reference Desk, call (406)721-2665, or send an email to
to reserve your title. We will need your name, phone number, desired title, pick up date, return date, and number of copies. Book Chat Bags must be picked up and returned directly to the Reference Desk and can only be checked out to one person in the group. Not a member of MPL? Contact us to have a Book Chat Bag sent to your home library.
Can I renew a Book Chat Bag?
Our Book Chat Bags are often booked months in advance and so we are not always able to extend your time on a Book Chat Bag reservation, but we are happy to accommodate your group whenever possible. Contact the Reference Desk at (406)721-2665 or
to inquire about Book Chat Bag renewals.
How can my book discussion group help?
Your can share your reading interests with other local book groups and help the library build its Book Chat Bag collection by donating paperback copies of books your book group has read. Please mention that your donation is for the Book Chat Bag collection when you drop the books off at the library.
Book Chat Bags are sponsored by the Friends of the Library and the Tamarack Library Federation.

domain: library


text:
Great People Make a Great Team!
At St. George Village Dental, we are dedicated to ensuring that patients receive the best dental care possible. As a group, we are committed to peak performance. We are continually taking courses to stay informed of the latest technologies and treatments in order that you receive the very best dental care available. We welcome any questions you may have and look forward to the opportunity to develop a long-lasting relationship with our patients and their families.
Dr. Shammick Kotecha
Dr. Shammick Kotecha graduated from the University of Manitoba’s Faculty of Dentistry in 2000. He then obtained a second research degree; B.Sc.(Dent) in 2001. Dr. Kotecha completed his residency at The Hospital For Sick Children in 2000 and was a staff dentist at Trillium Hospital from 2001-2006. He is currently studying at the Spear Institute and has been helping to create healthy smiles for over 11 years.
Dr. Kotecha is a member of the Canadian Dental Association, Ontario Dental Association and the Academy of General Dentistry. He enjoys all aspects of dentistry including restorative, endodontics and crown and bridge. In addition, he provides laser dentistry and minimally invasive dentistry. Dr. Kotecha has a particular interest in new dental technology. Creating a comfortable and friendly environment is important for Dr. Kotecha.
Outside of dentistry, Dr. Kotecha loves to spend time with his wife and daughter and enjoys travelling. He likes to watch and play sports and is an avid collector of sports memorabila.
Dr. Justin Abbott
Dr. Justin Abbott is very excited to be joining our dental team and looks forward to be part of the growing community of St. George, ON, ON. Dr. Abbott grew up in Windsor, ON, where he attended high school and received a Bachelor’s degree in Biology at the University of Windsor. He then attended the University of Western Ontario and attained his Doctor of Dental Surgery degree. He is a current member of the Canadian Dental Association and the Ontario Dental Association. He has a passion for all aspects of general dentistry.
Dr. Abbott is welcoming new patients and looks forward to serving you, and your family and friends living in St. George, ON, ON and surrounding townships. In his spare time he enjoys travelling, the great outdoors, fitness and spending time with family and friends.
Steven Chychul - Denturist
Steven Chychul is the practising denturist at the St. George Village Dental. Steven was raised in Norfolk County, attending the Waterford District High School. Upon graduating, he attended the University of Western Ontario and then George Brown College.
Steven is licenced with the College of Denturists of Ontario, and is a registered member of the Denturist Association of Ontario, and the Denturist Association of Canada.
Steven proudly provides full service denture clinic at the St. George Village Dental. The services at our practice include: repairs, relines, fabrication of new complete and partial dentures, and implant supported dentures. No referrals are necessary to schedule an appointment with our denturist.

domain: medical


text: Let’s talk about the Politically Correct Philosophy of Social Justice, or as it is known by it’s Politically Un-Correct name of Black Liberation Theology propounded by Rev. Jeremiah Wright. It is being practiced by Obama, who is imposing it’s values on America without calling it a Religion so he can get around the Constitutional Prohibition against the Federal Government establishing a State Religion. He has used it to basically transform America with a backwards step into discrimination and class warfare. Until we get back to the original ideology of Equal Justice for ALL under the law, and make sure that philosophy is carried out without regard to race, religion,color, and ethnic origins, there will be social unrest and class warfare.

domain: sociology


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Newhill Farm Cottages
Auchtermuchty, Cupar, Fife
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St Andrews Coach Houses
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St. Andrews Coach Houses comprise of four luxury self catering lodges, one with a fabulous hot tub, that have been converted to the highest standard and enjoy panoramic views of the surrounding Fife countryside. Our holiday homes are only a 5...
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Sandford Country Cottages are set in stunning Fife countryside and consist of 6 luxury self catering properties which are 5 Star Visit Scotland rated. Located just 10 miles from St Andrews and 5 miles from Dundee. Each property has a very well...
43 Shoregate Cottage
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AccommodationThe house is on two floors with one double...
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Kilrie, Kirkcaldy, Fife
Kilrie Granary is a 19th Century property providing spacious self catering accommodation in Kilrie near Kirkcaldy. The cottage is surrounded by beautiful scenery and plenty of nature. It is also ideally placed for visiting the city of Edinburgh...
Pittenweem, St Andrews, Fife
Kilheugh Cottage offers self catering holiday accommodation situated in St Andrews, Pittenweem, Fife. This 400 year old cottage is situated in the small fishing village of Pittenweem on a quiet wynd with beautiful views over the harbour, the...
The Courtyard @ Crail
The Courtyard @ Crail, are 2 Apartments one upstairs and one downstairs. Ideal for 2 families or a group of friends. Centrally located in the heart of Crail, a short walk to the Chippy or Pub.
No. 60Ground floor Apartment, open plan lounge with...

domain: geography


text:
- Does watermelon flatten your stomach?
- Can I eat too much watermelon?
- Is it OK to eat watermelon at night?
- Is it OK to eat a banana every day?
- Does watermelon help burn belly fat?
- Is there a lot of sugar in watermelon?
- Do eggs burn fat?
- What 2 vegetables kill belly fat overnight?
- How can I flatten my stomach naturally?
- What can I drink to get rid of belly fat?
- Does lemon water burn fat?
- How can I lose tummy fat fast?
- Does watermelon make you poop?
- What food has zero calories?
- What fruit burns the most fat?
- What are the benefits of eating watermelon?
- What are the 5 foods that burn belly fat?
- How can I reduce my tummy in 7 days?
Does watermelon flatten your stomach?
Watermelon is another fruit that’s high in potassium to cut down on water weight.
According to a study in the journal Nutrition, watermelon is also a fantastic source of arginine, an amino acid that assists the body in burning fat quickly.
Try this eating plan for a flat-belly day..
Can I eat too much watermelon?
If eaten in reasonable amounts, watermelons should produce no serious side effects. If you eat an abundance of the fruit daily, however, you may experience problems from having too much lycopene or potassium.
Is it OK to eat watermelon at night?
Watermelon has 92% water content. While it does solve your hydration blues in peak summers, having it at night can potentially make you take more trips to the bathroom, disturb your sleep. In some cases, watermelon, if not eaten in control can lead to the problem of water retention, causing swelling and overhydration.
Is it OK to eat a banana every day?
Bananas are one of the most popular fruits in the world. They’re full important nutrients, but eating too many could end up doing more harm than good. Too much of any single food may contribute to weight gain and nutrient deficiencies. One to two bananas per day is considered a moderate intake for most healthy people.
Does watermelon help burn belly fat?
Watermelon: A hydrating fruit rich in lycopene, it will increase your body’s arginine levels, an amino acid that ups the body’s fat-burning potential. At the same time the juicy red fruit helps the body burn fat, it also builds lean muscle. Just 1 cup a day does the trick.
Is there a lot of sugar in watermelon?
Watermelon. A medium wedge of this summer treat has 17 grams of sugar. As its name suggests, it’s loaded with water, and it has special minerals called electrolytes that are just what your body needs to recharge after some time in the sun. Just keep it to a slice or two.
Do eggs burn fat?
This means that high-protein foods, such as eggs, help you burn more calories. Bottom Line: A high-protein diet may boost your metabolism by up to 80–100 calories per day, since extra energy is needed to help metabolize the protein in foods.
What 2 vegetables kill belly fat overnight?
Here Are Some Of The Best Vegetables That You Can Include In Your Diet To Lose Belly Fat Quickly:Spinach And Other Leafy Greens. Spinach and other leafy green vegetables like kale, lettuce, etc. … Mushrooms. … Cauliflower And Broccoli. … Chillies. … Pumpkin. … Carrots. … Beans. … Asparagus.More items…•
How can I flatten my stomach naturally?
The 30 Best Ways to Get a Flat StomachCut Calories, but Not Too Much. Share on Pinterest. … Eat More Fiber, Especially Soluble Fiber. … Take Probiotics. … Do Some Cardio. … Drink Protein Shakes. … Eat Foods Rich in Monounsaturated Fatty Acids. … Limit Your Intake of Carbs, Especially Refined Carbs. … Do Resistance Training.More items…•
What can I drink to get rid of belly fat?
The 8 Best Weight Loss DrinksGreen Tea. Share on Pinterest. … Coffee. Coffee is used by people around the world to boost energy levels and lift mood. … Black Tea. Like green tea, black tea contains compounds that may stimulate weight loss. … Water. … Apple Cider Vinegar Drinks. … Ginger Tea. … High-Protein Drinks. … Vegetable Juice.
Does lemon water burn fat?
Lemon water can promote fullness, support hydration, boost metabolism and increase weight loss. However, lemon water is no better than regular water when it comes to losing fat. That being said, it is tasty, easy to make and can be used as a low-calorie replacement for higher-calorie beverages.
How can I lose tummy fat fast?
20 Effective Tips to Lose Belly Fat (Backed by Science)Eat plenty of soluble fiber. … Avoid foods that contain trans fats. … Don’t drink too much alcohol. … Eat a high protein diet. … Reduce your stress levels. … Don’t eat a lot of sugary foods. … Do aerobic exercise (cardio) … Cut back on carbs — especially refined carbs.More items…•
Does watermelon make you poop?
Watermelon. It doesn’t have a lot of fiber, but it’s 92% water, and that can encourage a bowel movement. It’s also chock full of nutrients, with antioxidants that help protect your cells, as well as vitamins A, B, and C, and lycopene, which helps shield you from UV rays.
What food has zero calories?
38 Foods That Contain Almost Zero CaloriesApples. Share on Pinterest. … Arugula. Arugula is a dark, leafy green with a peppery flavor. … Asparagus. Asparagus is a flowering vegetable that comes in green, white and purple varieties. … Beets. Beets are root vegetables that typically have a deep-red or purple color. … Broccoli. … Broth. … Brussels Sprouts. … Cabbage.More items…•
What fruit burns the most fat?
Here are some fruits that are known to cut belly fat:Apple. Fresh and crunchy apples are packed with healthy flavonoids and fibres that may help burn belly fat. … Tomato. The tangy goodness of tomato may do wonders to cut your belly fat. … Guava. … Strawberries. … Kiwi.
What are the benefits of eating watermelon?
Here are the top 9 health benefits of eating watermelon.Helps You Hydrate. … Contains Nutrients and Beneficial Plant Compounds. … Contains Compounds That May Help Prevent Cancer. … May Improve Heart Health. … May Lower Inflammation and Oxidative Stress. … May Help Prevent Macular Degeneration. … May Help Relieve Muscle Soreness.More items…
What are the 5 foods that burn belly fat?
Eight Delicious Foods That Help Fight Belly FatBelly Fat-Fighting Foods.Avocados.Bananas.Yogurt.Berries.Chocolate Skim Milk.Green Tea.Citrus. Supermarket shocker: Vitamin C in colorful produce, like oranges and red peppers can help you zap up to 30 percent more fat during exercise, research from Arizona State University at Mesa suggests.More items…•
How can I reduce my tummy in 7 days?
Additionally, check out these tips for how to burn belly fat in less than a week.Include aerobic exercises in your daily routine. … Reduce refined carbs. … Add fatty fish to your diet. … Start the day with a high protein breakfast. … Drink enough water. … Reduce your salt intake. … Consume soluble fiber.

domain: food


1000 Mile Fusion Sport Sock - SALE
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Russia’s NTMK Nizshnly Tagil, part of the global Evraz Group, decided to schedule Greenfield construction for a new blast furnace in the deep freeze of icy winter in the Ural Federal District.
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Free Music I Can Use on Facebook: Facebook is a great place for video creators to share their content. The platform encourages users to try and outdo one another by creating unique and engaging videos. Many of these creators also attempt to spruce up their videos by adding music
If you upload long videos containing music to Facebook regularly, you may have noticed some of them being muted or blocked. This issue usually occurs when the video contains copyrighted music that doesn’t adhere to the platform’s music licensing agreements.
The good news is that there are plenty of places that offer music for Facebook. So if you were wondering, “Where can I find free music I can use for Facebook?”, you’ve come to the right place. Today we will be looking at the three best places to find free music for Facebook.
Free Music I Can Use on Facebook – The Best Sources
The Facebook Sound Collection is a special section on Facebook dedicated to providing users with free music for their videos. The library contains over 9,000 tracks, many of which sound like complete songs.
Each of the tracks on Facebook Sound Collection is owned by Facebook. This means the platform owns the rights to tracks, so users can feature them in their Facebook videos without worrying about copyright issues or paying royalties.
Users can look up the perfect song for their video using the different filters such as:
You can preview a track in the collection by clicking the “Play” icon. If you like what you’re hearing, you can instantly download the track by clicking the “Download” icon.
Users should note that they have permission to use this music for only Facebook and Instagram videos. They may run into issues if they attempt to use them on other platforms such as Snapchat or Vimeo.
Chris Hoermann is an indie musician who has uploaded his own music to his website. He allows users to download his music for free and use it in their Facebook videos. The site currently has around two dozen tracks that span different music genres. Users can preview each track on Soundcloud and download them in high-quality from the website.
There are a few conditions associated with using Chis Hoermann’s music in your Facebook videos. The first condition is that users must sign up on the website and be added to its mailing list.
Users may also receive a content-ID-claim if they upload Facebook videos containing Hoermann’s music. However, they can continue sharing their video without any issues. The third condition is that users must offer Hoermann a share of any revenue their videos generate. If you can abide by these conditions, you’ve found a great website for music for your Facebook videos!
Free Music Archive is another free online library that offers royalty-free music for online videos. It was started by New Jersey-based radio station WFMU in 2009 and aims to offer music under a Creative Commons License. Users can download tracks for absolutely free and use them in their Facebook videos as they please. The website also gives you the option of “tipping” artists whose works you have downloaded. However, it isn’t necessary to pay them.
Users can browse through various genres such as:
They can also look up the most downloaded tracks in the past week, past month, or all time. All these features make the search process a breeze. If you’re looking for thousands of great-sounding free tracks to use for Facebook, the Free Music Archive is certainly one of the better options out there.
Each of the resources mentioned above is great for finding free music for your Facebook videos. Be sure to browse their catalog carefully when searching for music. After all, the right track can spruce up your Facebook video and make it more engaging for users. So consider reviewing the above list the next time you seek out background music for your Facebook video content.
Looking for more music for your Videos? Check out these resources:

domain: entertainment


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Medical embryology is one of the important subject and branch of human anatomy usually this books is thought during the first and second year of mbbs or other medical studies there are various books for this subject embryology but langmans embryology is one of the best and standard books for clinical embryology that includes all the . Langmans essential medical embryology is the ideal text for medical and health professions education programs that are shortening and condensing their coverage of embryology the book combines concise but thorough descriptions with over 400 full color illustrations mostly taken from the renowned langmans medical embryologyemphasis is placed on illustrating development with only the . Langmans medical embryology covers embryology for medical nursing and health professions students with a strong clinical emphasisthe text is highly valued as a teaching and learning resource for its clinical correlation boxes summaries problems to solve illustrations and clinical images and clear concise writing style all of which make the subject matter accessible to students and . Free books online pdf langmans medical embryology 14th edition pdf however a basic knowledge of embryology is essential to the success of these strategies and with this knowledge every health care professional can play a role in providing healthier babies to accomplish its goal of providing a basic understanding of embryology and its clinical relevance langmans medical embryology . Medical embryology is the study of the human development and for those who do not know langmans medical embryology is the most famous book in the world when it comes to the subject of medical embryology the study of human development is really complex and exhausting given the amount of detail the medical students have to absorb
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Toulouse, the friendly, hyper kitten that my playtesting sim adopted.
I wonder who could be in that attic room.
This is Winter. SQUEEE!
So adorable! ;___;
And that’s the last of the Holly posts for a while. My game crashed before I was smart enough to save the game. Oops. But I saved her as a .sim file, so I might play her again someday. :)

domain: game


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‘Canto I’ is the first piece of Pound’s The Cantos. He started this enormous undertaking when he was thirty years old and worked on it till his death in 1972, spawning a total of fifty-seven years. In The Cantos, readers get an insight into Pound’s mind. It is in total around 600 pages in length and yet unfinished. This particular canto is unusual. It is a loose translation of one passage of The Odyssey, attributed to Homer and written 2,500 years ago. This particular passage details Odysseus’s journey to the edge of the world and his questioning of spirits from the underworld.
In this section of The Odyssey, Pound translates Odysseus’ journey into the realm of the dead. He speaks briefly on Circe’s island, what the trip along the sea is like, and then about the edges of the earth. There, he seeks out information about what’s going to happen in the next part of his journey. In the underworld, Odysseus runs into one of his friends who died on Circe’s island, Eplenor. He begs his friend to go back and give him a proper burial. He also sees his mother briefly and gets a prophecy from Tiresias. The prophet tells Odysseus that he’s soon to encounter the Sirens and, at some point, lose all of his friends.
You can read the full poem here.
Structure and Form
‘Canto I’ by Ezra Pound is a long three-stanza poem that is translated from the Ancient Greek. Pound, in order to maintain as much of the original’s structure as possible, looked to Old English meter (known today as an accentual meter) in order to structure the lines. This means that he focuses on the stressed syllables entirely. The unstressed syllables are much more random. These stressed syllables are emphasized through the use of literary devices such as alliteration and internal rhyme.
Pound makes use of several literary devices in his translation of this part of Homer’s The Odyssey. These include but are not limited to, examples of alliteration, enjambment, and imagery. The latter is one of the literary devices for which Pound is remembered today. As an imagist, the imagery was always of the utmost importance to him. There are several wonderful examples in ‘Canto I.’ For instance, these lines from the first stanza: “Heavy with weeping, and winds from sternward / Bore us out onward with bellying canvas.” The best examples of imagery are those which engage all of the reader’s senses.
Alliteration is another common device in poetry, one that involves a very specific type of repetition, the use, and reuse of the same consonant sound at the beginning of multiple words. For example, “stretched sail” in line nine of the first stanza and “bloody bever” in line five of the third stanza.
Enjambment is a formal device that pound uses several times in ‘Canto I.’ It is concerned with where the poet cuts off a phrase. For example, the transition between lines two and three of the first stanza and eight and nine of the third stanza.
And then went down to the ship,
Set keel to breakers, forth on the godly sea, and
We set up mast and sail on that swart ship,
Circe’s this craft, the trim-coifed goddess.
This poem begins in medias res, a technique in which a writer thrusts the reader directly into the middle of a story without providing peremptory information. In this case, the speaker brings the reader into a nautical scene in which they use sailing-related words in order to describe the situation. A group, the speaker, says, got the ship ready to sail and enter out onto “the godly sea.” On the ship, there are plenty of sheep for substance and for an as yet unknown reason, a great deal of sorrow. Something happened to the crew that’s still affecting them.
It’s in the seventh line of the first stanza that it becomes clear which part of Homer’s Odyssey Pound is focused on here. The speaker mentions Circe, a reference to a sorceress from the story. The men are setting sail in Circe’s boat after spending a terrible period of time on the island as pigs. It’s also at this point that it becomes clear that Odysseus is the speaker here.
Then sat we amidships, wind jamming the tiller,
Thus with stretched sail, we went over sea till day’s end.
Sun to his slumber, shadows o’er all the ocean,
Swartest night stretched over wretched men there.
Over the next four lines, there are several examples of alliteration, seen specifically in the use and reuse of words starting with an “s.” Odysseus also provides the reader with details about this new section of their journey. He speaks on the wind, the water, and the movement of the sun. They were moving at a pretty good speed.
In the twelfth line of this stanza, Odysseus mentions the Kimmerian, a mythical group of people who supposedly lived at the edge of the world. These wretched people lived forever in the mist and darkness of that place. There were no stars only eternal night.
The ocean flowing backward, came we then to the place
Aforesaid by Circe.
Here did they rites, Perimedes and Eurylochus,
Dark blood flowed in the fosse,
Souls out of Erebus, cadaverous dead, of brides
Of youths and of the old who had borne much;
In the next lines, Odysseus describes the ritual he and his men performed at the edge of the world, the place that Circe told them to go. He took out his sword and dug a “pitkin,” or a small pit, and everyone poured wine into it to honor the dead. Odysseus muses about the power of sacrifices, especially bulls, in the following lines. He adds a sheep t the pile for the blind prophet Tiresias. Because of all this praying and sacrificing, souls come out of “Erebus,” a part of the underworld.
Souls stained with recent tears, girls tender,
Men many, mauled with bronze lance heads,
Battle spoil, bearing yet dreory arms,
Pitiful spirit. And I cried in hurried speech:
“Elpenor, how art thou come to this dark coast?
“Cam’st thou afoot, outstripping seamen?”
The following lines of the poem elaborate on all the souls that come out of Hell. Most of these are youths, young women, or “girls tender”. There are also a lot of men, “mauled with bronze lance heads”. They come around Odysseus and shout at him. In order to appease them, he kills more animals and prays to the gods. He mentions Pluto, the Roman god of the underworld specifically, as well as Proserpine, his wife. The fact that so many dead men and women appeared, along with Odysseus’s attempts to get them to leave him alone, is likely meant to convey his guilt in regards to their deaths.
Unfortunately, Odysseus meets one of his friends in this realm of the dead, someone he didn’t actually know was deceased. He cries out to Elpenor, asking what happened to him. It turns out that he died on Circe’s island and didn’t get a proper burial. He was left “Unwept, unwrapped in spulchre.” He asks his friend how he got here and if he walked.
And he in heavy speech:
“Ill fate and abundant wine. I slept in Circe’s ingle.
“Going down the long ladder unguarded,
“And set my oar up, that I swung mid fellows.”
The second stanza is far shorter than the first. In it, Odysseus conveys what happened to his friend. He got drunk one night and fell and broke his neck while climbing down a ladder. He broke his skull and his spine, and his soul “sought Avernus” or entry into the underworld. Elpenor asks his friend to sail back to Circe’s island and take care of his body properly. Therefore he won’t have to stay in limbo for the rest of eternity. –
And Anticlea came, whom I beat off, and then Tiresias Theban,
Holding his golden wand, knew me, and spoke first:
In the first lines of the third stanza of ‘Canto I,’ the speaker describes how all of a sudden, Anticlea (his mother) shows up before Odysseus gets to answer Eplenor. He sends her off before running into Tiresias, the man he’s been looking for. This is the second time that Odysseus has existed in the underworld, and Tiresias notes that. Tiresias prepares to share a bit of knowledge with Odysseus in exchange for the drink of wine he’s brought him.
And I stepped back,
And he strong with the blood, said then: “Odysseus
“Shalt return through spiteful Neptune, over dark seas,
Cypri munimenta sortita est, mirthful, orichalchi, with golden
Girdles and breast bands, thou with dark eyelids
Bearing the golden bough of Argicida. So that:
The last lines of the canto include Tiresias’ words to Odysseus, a prophecy. He tells him that he’s going to need to go back the way he came and that he’s soon going to lose all of his friends. There is an interesting moment when Pound inserts the line “Lie quiet Divus” into the poem. This is an allusion to the medieval translator who published a Latin version of The Odyssey in 1538. Once the story resumes, Tiresias tells Odysseus that he’ll pass the Sirens on the next part of his journey.
Finally, Pound ends the canto by including a respectful dedication to Aphrodite. He uses the phrase “Cypria munimenta sortita est” which is Latin for “The citadels of Cyprus were her appointed realm,” suggesting that it’s only for love that a journey like this can be made. Without explaining why Pound felt like he needed to make a dedication to Aphrodite, the poem ends with “So that:”.
Readers who enjoyed the first canto of The Cantos should also look into some of Pound’s other best-known poems. These include ‘In a Station at the Metro’, ‘The River Merchant’s Wife’, and ‘The Garden’. Some other related poems include ‘On First Looking Into Chapman’s Homer’ by John Keats and ‘Odysseus to Telemachus’ by Joseph Brodsky. The former was written after Keats read Chapman’s translation of Homer for the first time on a night in 1815. ‘Odysseus to Telemachus’ is told from the perspective of the epic hero, Odysseus while he is stranded on Circe’s island.

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An initial association between vitamin A supplementation and reduced childhood mortality due to measles and diarrhea led to the assumption that vitamin A was crucial in the fitness of the immune system. This finding sparked curiosity about the mechanisms through which vitamin A could modulate the immune response. Today, it is recognized that vitamin A, through its metabolite retinoic acid, is able to induce gut homing receptors on T and B cells, allowing the trafficking of these cells to the intestine (and probably also to the inflamed tissues) to perform their effector functions and maintain an appropriate gastrointestinal balance between immunity and tolerance. Moreover, exposure to vitamin A in the womb is an important determinant for the development of secondary lymphoid organs during embryogenesis and after birth through induction of lymphoid tissue-inducer cells. In addition, vitamin A has shown to be essential for T cell activation and differentiation into different T helper subsets, such as Th1, Th2 and Th17 cells. On the other hand, in vitro studies have shown that RA is able to induce regulatory T cells, however the role of vitamin A in promoting oral tolerance has not yet been fully established. A far more complex picture has emerged for the role of retinoic acid in gut immunity since there is contradictory evidence for several of aspects of T cell differentiation. Such discrepancies could be explained by the fact that RA can mediate different effects depending on the dose used in different experimental settings and the context in which an immune response is occurring. Accordingly, it has been proposed that RA may have a dual effect, modulating regulatory T cell differentiation in the steady state while promoting T cell activation and Th1 and Th17 cell responses during an ongoing immune response. In addition, results in VAD mice should be interpreted with caution; taking into consideration that VAD mice present important alterations in intestinal epithelial cells, which affects the resident microbiota. The gut microbiota has an important effect on the differentiation of T helper subsets and Tregs in the gut. Therefore, the effects observed in VAD mice could be the consequence of an altered gut microbiota rather than a direct effect of RA on T cells. Although the development of better models and experimental techniques has allowed significant progress in the discovery of the mechanisms through which vitamin A broadly impacts the immune response, further studies are needed to fully unravel the role of vitamin A in T cell-mediated immunity.
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We then developed a co-culture technique of IsO cells and F9-1.8 re- porter cells to detect the production of RA by the former (Figs. 2A and 3). In order to test basal b -galactosidase ac- tivity, we co-cultured these two cell types with a chemically deﬁned me- dium; few F9-1.8 blue cells (Fig. 3A; see also Fig. 3F for a plotted compari- son with other co-culture conditions) were seen, suggesting that in the ab- sence of E-CSF, IsO cells are not self- sufﬁcient to synthesize retinoic acid. Conversely, when F9-1.8 and IsO cells were co-cultured in a deﬁned medium supplemented with E-CSF (Fig. 3B and F), the number of F9-1.8 blue cells signiﬁcantly increased, suggest- ing that E-CSF contains factors that activate the synthesis of retinoic acid by the IsO cells.
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components of RA, but as monotherapy often they are insuffi- cient to achieve remission or adequate control of the disease activity (Smolen et al., 2017). This circumstance has motivated the common use of drug combinations, with the most frequent including methotrexate together with a targeted biologic drug as one of the monoclonal anti – tumor necrosis factor (TNF) antibodies (Smolen et al., 2017). A sizable fraction of patients does not reach adequate response even with these drug combinations. Therefore, there is a growing interest in developing treatments aimed to revert the activated pheno- type of RA FLS (Niedermeier et al., 2010). Recently, we found that a transporter of retinoids, cellular retinoic acid binding protein 2, is a candidate drug target of this type because cellular retinoic acid binding protein 2 suppression reverts RA FLS resistance to apoptosis (Mosquera et al., 2018). In the same study, we observed unconventional responses of RA FLS to the main biologic retinoid, all-trans retinoic acid. These results prompted us to investigate further the effects of all- trans retinoic acid (ATRA) on the activated phenotype of RA FLS (Mosquera et al., 2018).
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Adoptive transfer of CD4+CD25+FOXP3+ regulatory T cells (Treg cells) has been success- fully utilized to treat graft versus host disease and represents a promising strategy for the treatment of autoimmune diseases and transplant rejection. The aim of this study was to evaluate the effects of all-trans retinoic acid (atRA) and rapamycin (RAPA) on the number, phenotype, homing markers expression, DNA methylation, and function of induced human Treg cells in short-term cultures. Naive T cells were polyclonally stimulated and cultured for five days in the presence of different combinations of IL-2, TGF-β1, atRA and RAPA. The resulting cells were characterized by the expression of FOXP3, activation, surface and hom- ing markers. Methylation of the Conserved Non-coding Sequence 2 was also evaluated. Functional comparison of the different culture conditions was performed by suppression assays in vitro. Culturing naive human T cells with IL-2/TGFβ1 resulted in the generation of 54.2% of Treg cells (CD4+CD25+FOXP3+) whereas the addition of 100 nM atRA increased the yield of Treg cells to 66% (p = 0.0088). The addition of RAPA did not increase the num- ber of Treg cells in any of these settings. Treg cells generated in the presence of atRA had an increased expression of the β7 integrin to nearly 100% of the generated Treg cells, while RAPA treated cells showed enhanced expression of CXCR4. The differential expression of homing molecules highlights the possibility of inducing Treg cells with differential organ-spe- cific homing properties. Neither atRA nor RAPA had an effect on the highly methylated CNS2 sites, supporting reports that their contribution to the lineage stability of Treg cells is not mediated by methylation changes in this locus. Treg cells generated in the presence of RAPA show the most potent suppression effect on the proliferation of effector cells. a1111111111
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Background: Membranous nephropathy (MN) is one of the causes of nephrotic syndrome in adults that lead to end-stage renal disease with an unknown molecular signature. The current diagnosis is based on renal biopsy, which is an invasive meth- od and has several complications and challenges. Thus, identification of the novel biomarker candidates, as well as impaired pathways, will be helpful for non-invasive molecular-based diagnosis. Objectives: We aimed to study the molecular signature of MN and facilitate the systematic discovery of diagnostic candidate biomarkers, molecular pathway, and potential therapeu- tic targets using bioinformatics predictions. Methods: The protein-protein interaction (PPI) network of an integrated list of downloaded microarray data, differential proteins from a published proteomic study, and a list of retrieved scientific literature mining was constructed and analyzed in terms of functional modules, enriched biological pathways, hub genes, master regula- tor, and target genes. Results: These network analyses revealed several functional modules and hub genes including Vitamin D3 receptor, retinoic acid receptor RXR-alpha, interleukin 8, and SH3GL2. TEAD4 and FOXA1 were identified as the regulatory master molecules. LRP1 and ITGA3 were identified as the important target genes. Extracellular matrix organization, cell surface receptor signaling pathway, and defense and inflammatory response were found to be impaired in MN using functional analyses. A specific subnetwork for MN was suggested using PPI approach. Discussion: Omics data integration and systems biology analysis on the level of interaction networks provide a powerful approach for identification of pathway-specific biomarkers for MN. (REV INVES CLIN. 2018;70:184-91)
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The goals of our study were to determine the possible association of interleukin (IL)-31 with Th17 cytokine profile in serum and to quantify retinoic acid-related orphan receptor C (RORC) mRNA expression in psoriatic arthritis (PsA) patients. This cross-sectional study was conducted in 50 patients with PsA and 30 control subjects (CS) matched by age and gender. The cytokine serum levels were quantified by magnetic bead–based assay using the Bio-Plex MAGPIX system, and RORC mRNA expression was determined by quantitative polymerase chain reaction (qPCR). As a result, significant differences in IL-31 were observed between study groups (77.23 pg/mL in PsA vs 64.4 pg/mL in CS, P < 0.001) and Th17 cytokine profile serum levels (IL-17A: 6.36 pg/mL in PsA vs 2.97 pg/mL in CS, P = 0.02; IL-17F: 44.15 pg/mL in PsA vs 23.36 pg/mL in PsA, P = 0.01; IL-17E: 3.03 pg/mL in PsA vs 0.82 pg/mL in CS, P < 0.001; IL-21: 36.45 pg/mL in PsA vs 12.44 pg/mL in CS, P = 0.02); however, significant differences were not observed for IL-23 (31.2 pg/mL in PsA vs 53.26 pg/ mL in CS, P = 0.58). Furthermore, positive correlations between IL-31 and Th17 cytokine profile serum levels were found (IL-17A: r s = 0.64, P < 0.001; IL-17F: r s = 0.73, P < 0.001; IL-17E: r s = 0.70, P < 0.001; IL-21: r s = 0.54, P = 0.002; IL-23: r s = 0.5, P < 0.01). Regarding RORC gene expression, the PsA group showed an increase of 6.85-fold compared to the CS group. We did not find any association between the serum levels of cytokines and RORC gene expression. In conclusion, in PsA, there are increased serum levels of IL-31, IL-17A, IL-17F, IL-17E, and IL-21, but not IL-23. Moreover, there was a positive correlation of IL-31 with the Th17 cytokine profile and a high RORC gene expression. Altogether, these findings suggest a proinflammatory contribution of IL-31 in close association with the Th17 cytokine profile in PsA.
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injections were made using a Rheodyne Injectable valve (20 μL loop). The detector wavelength was set at 254 nm. The chromatographic separations were performed at ambient temperature on a Gracesmart RP18, 5μ (250 mm x 4.6 mm). The mobile phase was a mixture of acetonitrile, water and concentrated phosphoric acid (400:600:5), filtered and degassed prior to use and flowing at the rate of 0.8ml/min. The measurements were performed at room temperature. The duration of each analysis was 37.5min. The data were collected and analyzed with analyst & crystal software in a computer system. About 2g of selected extracts of this plant was placed into a 50mL flask and extracted with 70% aqueous methanol solution (50mL) by boiling with reflux for 2h on a water bath. After cooling, the extract was filtered through a paper filter into a 100mL measuring flask and was subsequently made up to the mark with the same solvent and sonicated for 15 min. Then the solution was filtered through 0.45 μ filter porosity membrane filter prior to injection. The sample components were identified by comparison of their retention times to those observed in the chromatograms of reference solutions which were collected from the library data. The relative content of each component was determined by measuring the area under the corresponding peak and using the method of internal normalization 10 .
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Wieland, H. and O. Schlichting (1924). "Analysis concerning gallic acid. XX. Announcement. The breakdown of a tricarboxylic acid C13H20O6." Hoppe-Seylers Zeitschrift Fur Physiologische Chemie 134(4/6): 276-289. Wieland, H. and A. Wingler (1924). "The oxydation process mechanism VII, 1 The
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The stimulatory activity of pyridine-3-suIfonic acid upon the oxidátion of glucose by S. Jomzei was not surprising since MIZUNO and NOJIMA ( 14) found that this substance was a growth accessory factor for S. dYJenteriae. Fur thermore, MIZlJNO and TA M A R A ( 1 5 ) found that pyridine-3-sulfonic acid could
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series, G1316A COLCOM, serial # DE43646850) under the following conditions: 20μL of ethanol extract were injected for 20 minutes at 25° C, pressure at 95 bar and a flow of 1mL/min. A second characterization of the phenolic compounds was done using a reversed-phase high performance liquid chromatographic (RP- HPLC, LaChrom serie 7000 Merck-Hitachi (Darmstadt, Germany), a Symmetry C18 Waters (Ireland), 4,6x250mm, 5mM, Pre- column: Symmetry C18 3.9 x 20 mm,5 μm,) under the following conditions: 20μL of ethanol extract were injected for 31 minutes at 40ºC, using phase mixture A:2% formic acid mixture B: 3 2% formic acid: Methanol, 1:1 v/v mixture C: Methanol UV-wave Detection at 280nm, 310nm and 360nm. Compounds were quantified using peak area calculation, and partially identified using correlations between retention times.
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Acrylic acid 12.3 13.9 Isobutyl alcohol 7.1 18.0 Allyl alcohol 10.2 14.3 Isobutyric acid 12.2 14.4 Allyl bromide 14.4 9.6 Isopropyl alcohol 8.2 16.0 Allyl iodide 14.0 11.7 Isopropyl bromide 14.1 9.2 Ammonia, 100% 12.6 2.0 Isopropyl chloride 13.9 7.1 Ammonia, 26% 10.1 13.9 Isopropyl iodide 13.7 11.2
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manica showed to act as an aggregation attractant cue, the cuticular hydrocarbons were detected as the major com- ponent responsible for this pheromone . In the desert locust Schistocerca gregaria, the aggregation behavior of larvae is modulated by three sets of pheromonal com- pounds: aldehydes and acids emitted by the larvae them- selves, and phenols associated with their feces . In Heteroptera, the aggregation behavior of immature pen- tatomid bugs was investigated using cuticular extracts of six different pentatomid bug species, two aldehyde iso- mers elicited opposite responses, whereas the major cutic- ular hydrocarbon showed the highest attractiveness . Research on model species from Blattodea, Coleoptera, Diptera, and Lepidoptera orders showed that many phe- romones arise from modifications of fatty acid metabo- lism. For instance, the ketone contact sex pheromone of the female German cockroach, Blattella germanica, derives from elongation of a methyl-branched fatty acyl-CoA moiety followed by decarboxylation, hydroxylation, and oxidation [28,29]. The aggregation pheromone of Tribo- lium castaneum arises from a fatty acid precursor . Also the major components of the sex pheromones in Diptera (e.g. Drosophila and Muscidae) are derived from elongation of fatty acyl-CoA moieties followed by loss of the carbonyl carbon and the formation of the corresponding hydrocar- bon . Lepidopteran sex pheromones are also derived from fatty acids, with diverse combinations of desatura- tion, chain-shortening, and modification of the carbonyl carbon [32,33]. Chemical communication activity has been reported for several esters of C16 and C18 fatty acids in the honeybee . However, very few studies are avail- able describing the aggregation role of insect fatty acids, among them; FFA components were reported as aggrega- tion cues in the coleopteran Trogodermes granarium , and in social insects . Also, endogenous free fatty acids were reported to be involved in conspecific attrac- tion and food recognition in Protaphorura armata (Colle- mbola) .
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Ghrelin produces the phosphorylation of AMPK and pAMPK becomes active and phosphorylates and inactivates ACC, causing a decrease in malonyl-CoA levels, the physiological inhibitor of CPT1 enzymes. This action produces disinhibition of the CPT1A enzyme, an increase in fatty acid oxidation, and an accumulation of ROS, which are mainly buffered by UCP2. Previous studies demonstrated that all these metabolic changes occur in the VMN (López et al., 2008; Gao et al., 2013), and although not fully understood, they ultimately activate transcriptional events by eliciting increased levels or activation of key transcription factors, such as pCREB, FoxO1, and BSX. These transcription factors are responsible, in part, for the increase of orexigenic neuropeptides AgRP and NPY in the ARC. CPT1C is more expressed in the brain than CPT1A. Although it has very low CPT1 activity it is known to bind malonyl-CoA as CPT1A does. Thus, we proceeded to analyze the ghrelin signaling pathway in the hypothalamus of CPT1C KO mice to determine if CPT1C plays a role in this pathway.
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Both phytic acid (PA) and catechin (CA) are well known antioxidants of natural origin. They were fre- quently tried on experimental level as hepatopro- tectants, relying only on their antioxidant properties. The present study was conducted mainly to outline the other biochemical pathways underlying the hepato- therapeutic potential of both drugs and to check a pos- sible synergistic action if prescribed concomitantly. As both materials are frequently taken on a daily basis in food and drinks, it will be helpful to pursue their possi- ble utility and/or to check if their value is really of medical importance. For this purpose, CCl 4 was used as a hepatotoxin, we evaluated plasma total sialic acid (TSA), serum ascorbic acid (AA) levels, liver tissue thiobarbituric acid reactive species (TBARS) as a marker for lipid peroxidation and total protein (TP) content as a rough marker to measure hepatic synthet- ic capability in 80 male Wistar rats as experimental models. Animals were classified into 8 groups (10 rats each), the first as control, the second as PA treated (0.3 mg kg -1 ), orally, the third as CA treated (30 mg kg -1 ),
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exothermic peak appears in the range 200–350°C after the departure of the remaining water molecule at ca. 120°C. The formation temperature of the oxide prepared ranges from 300 to 400°C. The exothermic effect corresponds to the combustion of carboxylic acid and nitrate/acetate ions. More than half of the weight loss occurs during this stage because of a violent oxidation-decomposition reaction. During the combustion process, the solution turned into brownish black powder. Assuming that complexing agents provide combustion heat for calcination in the synthesis of oxide powders, it appeared that these carboxylic acids act as fuels during the pyrolysis of the precursor, accelerating the decomposition of nitrate/acetate ions in the process. Eventhough crystallization started below 400°C, well-crystallized and pure phases were obtained at 600°C. While pyrolysis procedures at this stage were very complicated, it could be presumed that the last weak exothermic peaks at ca. 380–398°C in the DTA curves of citric acid- and glycine-assisted methods correspond to the crystallization of the LiNi 0.5 Co 0.5 O 2 phase.
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The influence of the reaction temperature on the extent of the controlled depolymerization of cellulose was assessed in the temperature range from 70 to 150 C, using two types of mineral acids as catalysts: sulfuric and hydrochloric acid (Table 1, entries 2e7). The addition of these catalysts was adjusted to get the same concentration of protons in the re- action media in order to properly compare their influence on the depolymerization of the catalysts. Reactions were per- formed in presence of a stoichiometric amount of water to get a theoretical complete cellulose hydrolysis. For this purpose, the amount of water accompanying the mineral acid was taken into account. A blank reaction test was also carried out for comparison purposes (Table 1, entry 1). In this experiment no mineral acid was added to the reaction media, but per- formed at 100 C and keeping constant the rest of the exper- imental conditions, including de addition of water. The first observed difference found in this experiment with regards to the rest of the tests performed in presence of mineral acid, is the readily precipitation of cellulose during the addition of water. This different behavior impossibilities the hydrolytic attack to the 1,4 glucoside bondings of cellulose, leading to a negligible yield towards glucose or any other by-product. These results suggest that simple presence of the ionic liquid species is not able to provide cellulose depolymeriza- tion, while revealing the needing of mineral acid to effectively maintain the cellulose in solution.
8 Lee mas
The propylene is fed from a storage tank. Air is compressed as a source of oxygen. Steam is used to provide thermal ballast for the exothermic heat of reaction. After being mixed, the feeds enter the reactor. Reactor effluent proceeds to a quench tower (T-301) where the reaction is rapidly quenched, to avoid further oxidation, with a cool acrylic acid recycle stream. Additional recovery of acrylic acid and acetic acid occurs in an absorber, T-302. The stream leaving the absorption section is a dilute, aqueous acid mixture. It then proceeds to an extraction unit, X- 301, which contains and extractor and a solvent recovery tower. This unit was designed and is operated under contract by ExtractoCorp. Stream 15 contains virtually all of the acrylic acid and acetic acid fed to X-301. Final purification occurs in T-303, where 99.9 mole% acrylic acid is produced as the bottom product, and 95 mole% acetic acid is produced as the top product. The acrylic acid product is cooled prior to being sent to storage. The acrylic acid temperature should never exceed 90°C in order to avoid spontaneous polymerization.
21 Lee mas
Only one continuous culture could be found for O. oeni (Zhang & Lovitt, 2006). In this study, the growth performance of the strain NCIMB 11648 was assessed at dilution rates between 0.007 and 0.052 . The authors determined dry cell weight, substrate uptake (fructose and glucose) and product formation (lactate, acetate, mannitol and ethanol) rates, as well as yields (maximum growth rate, maximun cell productivity, biomass yield and maintenance coefficient). Nevertheless, this study was carried out in the absence of ethanol, malic acid and citric acid, which could have significantly affected the physiology of the microorganism. Additionally, considering the high genotypic and phenotypic variation between strains (Borneman et al., 2012), we preferred to employ experimental data from the strain PSU-1 to refine our model and not use this data.
158 Lee mas
BAs belong to a family of closely related acidic sterols synthesized from cholesterol, and represent the main catabolic pathway of cholesterol metabolism in humans. BAs are classified as soluble amphiphiles because of the ionized carboxylate or sulfonate group on the side chain that makes BAs water-soluble. In general, BAs possess a steroid nucleus of four fused hydrocarbon rings with po- lar hydroxyl functions. De novo BA biosynthesis occurs in the liver as the “primary” BAs, i.e., cholic acid (CA) and chenodeoxycholic acid (CDCA). Afterwards, the water solubility of BAs is increased by conjugation to either taurine or glycine, followed by hepatic secretion of BAs into bile and release by the gallbladder into the duode-
11 Lee mas
According to the results obtained during the anaerobic batch assays, most suitable pH for produce VFAs was 8, since at this pH the highest concentration of VFAs was obtained (5276 mg/L). The VFAs obtained were mostly acetic (1652 COD mg/L) and butyric (2928 COD mg/L) acids. Also, propionic acid was obtained, but in a lower concentration (697 COD mg/L). The higher concentration was obtained at 8 days of operation, after which the concentration of VFAs decreased suggesting that VFAs were converted to other products. The increase of CH4 production after day 8, confirm the decrease on VFAs concentration due to their conversion into CH4 thus completing the cycle of anaerobic digestion.
19 Lee mas

domain: literature


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text:
Chemotherapy for Inoperable Liver Metastases from Ocular Melanoma
Name of the Trial
Why is This Trial Important?
In this study, researchers are testing a procedure called hyperthermic isolated hepatic perfusion, which involves temporarily separating the liver's blood supply from the blood circulating throughout the rest of the body. High concentrations of the drug melphalan are then administered to the liver. Once treatment with melphalan is completed, the liver's blood supply is reconnected to the rest of the circulatory system and patients are treated with the drug temozolomide.
"Isolating the liver allows us to deliver a higher dose of melphalan than could be tolerated systemically," said Dr. James Pingpank, a surgeon involved with the trial. "Isolated perfusions have been used to treat cancer in other organs, but this is the first time isolated hepatic perfusion is being used with a large number of patients. The technology just wasn't there before.
"In phase I and II testing, this therapy did produce a response in 62 percent of patients, so it does have established efficacy," said Dr. Pingpank. "Now we are trying to prolong the duration of response, which is currently about 1 year."
Who Can Join This Trial?
Where Is This Trial Taking Place?
Whom to Contact
An archive of "Featured Clinical Trial" columns is available at http://cancer.gov/clinicaltrials/ft-all-featured-trials .

domain: biology


text:
Six months after Detroit emerged from bankruptcy, Michel Martin heads there to hear from the artists, thinkers and entrepreneurs who are shaping the city's future.
A mysterious set of medical complications plagues some survivors: joint pain, vision loss, rashes. Doctors aren't sure why it's all happening. But they have a name for it: post-Ebola syndrome.
Thirteen-year-old Nicholas Heyward Jr. was playing with a toy gun in the stairwell of the housing complex where he lived in Brooklyn when a police officer shot and killed him in 1994.
John Sopko says the Afghans still do a poor job of managing the billions they get from the U.S. and he's documented the abuses. Still, he supports the ongoing U.S. efforts there.
The green health halo hovering over kale glows brightly, and the company is putting it in breakfast bowls in nine southern California locations. Will it help brighten up the Golden Arches?
Ayelet Shaked is a secular Jew who belongs to a religious party closely tied to West Bank settlers. She's faced criticism for controversial statements about Palestinians.
The city has some of the highest auto insurance rates in the U.S. Many residents there drop coverage — or claim they live outside the city limits. The mayor has a plan to cut the cost of insurance.
Historian Richard Rothstein studies residential segregation in America. His conclusion: "federal, state and local governments purposely created racial boundaries in these cities."
No one has been a late-night TV host longer than David Letterman, who retires Wednesday after 33 years. Here's what he told TV Critic Eric Deggans about leaving the Ed Sullivan Theater one last time.
A mouse brain boasts more than 200 different kinds of cells, say scientists, who are busy cataloging everything known about each type. Next up: a data trove of details on human brain cells.

domain: news


Wall Street Journal - April 29, 2010 - By Craig Karmin
Help Protect Central Park - A National Historic Landmark and New York City’s first Scenic Landmark - From Commercial Encroachment!
In an effort to generate additional revenue for the City, The City of New York/Parks and Recreation is proposing building four - 35-foot high, diesel powered tennis bubbles covering 26 tennis courts in Central Park for 5 months of the year. Additional time would also be required each Fall to erect the bubbles, and to remove them in the Spring which would would cut into existing outdoor use. The proposed contract would be for 15 years. This is a for profit venture by the City and a private company. The bubble structure will transform and negatively alter the visual enjoyment that the public has enjoyed for more than 70 years.
• Admission will cost up to $100 per hour according to the Parks Department. Currently the cost to play tennis for the entire season is $100. The hefty price tag to play undermines the "democratic character" of the park. Help prevent the City from turning Central Park into a Cash Cow.


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Adjustment of Ringfeder Clamps 26 Check axial clearance of drum cam by a dial indicator as shown in figure by lifting and lowering the cam gear by hand. Aprueba tu examen de conducir.
Loosen clamping screws 15 of friction ring coupling and pull out the index gear May require frequent changes. Screws 30 and 44 should be tightened firmly after coating bp with anti vibration solution like Locktite.
Now tighten the bolts 15 to clamp indexing gear 13 on the spindle. Cam follower roller Track roller Track roller pins 42 78 77 Spindle assembly Indexing drive Indexing drive 3 8 8 Accidental collisions are not un-common in the field of CNC lathes. Remove the plug, the spring and the valve button.
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Electrical motor wiring diagram. Remember me Forgot password? Coolant passage through the turret body, coolant ring and the valve has been designed to provide as little resistance to coolant flow as possible.
Operation of Coolant system: Stage Lp Btp bon.
Pragati – BTP Turret Manual
Also make a reference mark by a marker pen on coolant flange 26 as well as on coolant ring outer They also give excellent protection against damage by hot chips. Tighten bolts 15 with a light force. Faults and corrective actions. Our role in relation to inspecting British Transport Policehttp: Instructions for fitment on the machine.
Replacement of proximity switch: Unused electrical entry points to be properly plugged.
Pragati – BTP Turret Manual – PDF Free Download
Fitment on the machine: There is one more reason for avoiding the dowel pin. We share information about your activities on the site with our partners auttorizacion Google partners: It is therefore necessary to select a particularly fast PLC programmable manula controller for the control of turret operation. For replacement, loosen the clamp and move the coolant ring to bring the valve in a suitable position to get access to the plug Printed inChina for repairing purpose.
Hand cranking is required for inspecting the setting of encoder and proximity switch.
This is a difficult operation to be done on site, and is most likely to be less than perfect. Focus on the peripheral mu opioid receptorantagonist methylnaltrexone Drugs Proper clamped position is indicated by lighted LED on proximity switch Then gently fit the encoder in position ensuring that slot fits properly on the manul.
Proximity switch adjustment and replacement fig.
Furthermore, coolant has to pass through drilled passages in the tool disc, before reaching the tool point. Tighten opposite bolts in sequence 1,5,2,6,3,7,4,8.
This ring has spring loaded coolant valve. Replacement of the proximity switch 15 Your consent to our cookies if you continue to use this website. Tighten locknut by hand, so that it will press the springs with a light pressure. Figure Bicycle Collisions and Parties at Fault manusl In some controls, a “block search” operation can cause the turret to index to a tool position bbtp after the axis are repositioned after block search.
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text: H.P. Lovecraft’s New York City Walks The following is a guest post by Jane Rose, creator and leader of our newest tour, “Lovecraft in Brooklyn.” Jane comes by her interest in H.P. Lovecraft, weird horror, and the supernatural honestly due to her upbringing in rural New Hampshire, where crumbling Colonial houses and centuries-old graveyards abound. A writer, filmmaker, and sometime special fx makeup artist, her movies have screened at the H.P. Lovecraft Film Festival in Portland, Ore, and elsewhere. 1920’s horror writer H. P. Lovecraft did not much relish his two years living in New York City (and that is putting it very mildly). He considered himself forever a New Englander and spent his long months of exile pining for his home in Providence, RI. But if there is one way that Lovecraft did resemble a typical New Yorker, it was that he was a walker. Contrary to one stereotypical image of Lovecraft, he was not a sickly shut-in (at least not after a rough patch in his teens and early 20’s), nor did he reject all external entertainments in favor of the internal activities of his own weird brain. In fact, he was a keen explorer, particularly when it came to destinations that spoke to his antiquarian interests. Lovecraft’s proclivity for walking and exploration was particularly evident during his New York period, and the way he went about it was actually pretty badass. He would walk long distances, often at night, and often all night. Like a hardcore urban explorer, he was known to sneak or break into sketchy or off-limits areas to get at what he wanted to see. His close friend George Kirk, writing in the morning hours to his fiancée after an exhausting all-night jaunt through the West Village with Lovecraft, refers to the “charms of the last 12 hours” and the “joy of the hunt and discovery, the excitement of seeing a perfect specimen (of Colonial architecture) between a row of modern apartments.” These explorations were more than mere sightseeing for Lovecraft. On the one hand, they inspired his stories (his nighttime strolls through the West Village notably inspired his short story He, while his exploration of Elizabeth, NJ, helped inspire The Shunned House). Moreover, they represented a fervent and life-sustaining search. Underemployed, broke, homesick, and in love with the antiquarian and mysterious (not to mention xenophobic and appalled by the people around him—a subject from which the Lovecraft in Brooklyn tour does not hide), Lovecraft found the modern world both prosaic and exhausting. He walked at night both to avoid the crowds and to imagine his surroundings as something other than what they appeared to be by day. He walked in search of older structures and relics (the early 18th century was his favorite time period) that spoke to a deeper history underlying the surface of the city, and which he feared were under threat from the onslaught of progress. Mixed chagrin and relief are reflected in a 1922 letter to his Aunt Lillian, in which he says of the Dutch Reformed Church in Flatbush: “Most of the original village edifices have long been destroyed, & replaced by blocks of shops & apartment houses; but some benign fate has preserved the ancient village church, whose ivy-twined belfry & spire still dominate the local sky-line.” Some days in Brooklyn it’s easy to identify with Lovecraft. On every corner (particularly in Williamsburg where I live), as older, often interesting structures are being razed and replaced with gleaming, glassy luxury condos. Weed-grown lots, few and far between, and suggesting a sort of urban wilderness, are tamed, filled in, and made productive. The Brooklyn Navy Yard’s Admiral’s Row had that alluring romantic decay and served as a reminder of the waterfront’s older days, but it was also considered an “eyesore” and the property underutilized (hence its destruction last year). We can take encouragement and inspiration, however, from Lovecraft’s perambulations. Both in Lovecraft’s time and today, a stroll can tease the extraordinary from the mundane. There may be a Starbucks every few blocks, but if one wanders far enough one is bound to stumble on something that provokes surprise or wonder. Do a little digging and research, and even more surprises may come to the surface. In a city with as many layers as New York, turning over a few rocks is likely to reveal some strange creatures. And walking tours (whether one is participating in or writing and researching one) are particularly aimed at scratching below the surface, tying past to present, and making connections where at first there appeared to be none. Hopefully the Lovecraft in Brooklyn tour will prove revelatory for those who come along. Click here to buy tickets to Lovecraft in Brooklyn.


text:
Lily Nwora is a personal trainer and founder of Dresses & Dumbbells have been featured on multiple news, media, and print outlets. Lily paid off $70,000 over 3 years and knocked out $40,000 in 2018 alone!
[2:48] Tell us a bit about yourself
- Registered dietician and personal trainer and acquired some debt
- Mainly student loans
[4:11] What financial hurdles are you most proud that you have overcome?
- Lifestyle creep was hard when she started making money and wanted a big apartment
- You’re (almost) always going to have some living above you so if it’s in an apartment building or basement, it doesn’t make much difference.
[10:41] What link do you see between physical fitness and financial fitness?
- Having a set plan
- Setting a deadline
- Putting in place a plan that you’ll actually stick to!
[13:46] What was you plan to pay off debt?
- Lily didn’t make a plan and was enraged when she discovered how little went to her principal payments
- Started listening to Dave Ramsey and started paying off extra each month (over 3 times!)
[18:6] Give us a 60 second elevator pitch about your workouts.
- Platform to empower women to be strong and have a strong mindset
[26:2] What does your saving and retirement plan look like?
- Investing in a 401k and doing the match
- Roth IRA
- Saving 3-6 months of expenses as recommended by Dave Ramsey
- Extra streams of income
[27:52] What are some favorite books you can recommend?
- Podcast: Dave Ramsey Podcast
- Book: First Steps to Wealth by Dani Johnson
[28:47] A favorite quote?
- If you don’t ask you don’t get
[29:54] Parting piece of advice?
- Just start, things are not going to be perfect
Start with a plan!

domain: finance


On Friday, the former ABC journalist and investigative reporter, James Gordon Meek, pleaded guilty to federal child pornography charges.
In April of 2022, a magistrate judge in the Virginia Eastern District Court approved a search warrant for his Arlington penthouse apartment. Following this lightning raid by the FBI, Meek went missing and his laptop was seized as evidence.
Meek had achieved notable success during his career with ABC News he produced the Hulu documentary “3212 Unredacted” which investigated and uncovered details on the Pentagon coverup of US special forces deaths in Niger in 2017. This groundbreaking work had earned him an Emmy award.
The New York Post reported that if agents got hold of Meek’s records, it would have been approved by US Deputy Attorney General Lisa Monaco – a clear indication that this case was being taken seriously at the highest levels.
The Rolling Stone also reported on Meek’s disappearance shortly after the raid took place, noting that many were concerned about what could have happened to him after going missing so suddenly.
Now with confirmation of his plea agreement to federal child pornography charges, we can begin to understand some of what may have led up to this moment.
It is unclear at this time how much prison time he will serve or if any other mitigating factors are involved in his sentencing decision due later this year.
ABC News reported:
A former investigative journalist for ABC News pleaded guilty Friday to federal child pornography charges.
James Gordon Meek, 53, of Arlington, Virginia, admitted in U.S. District Court in Alexandria that he illegally possessed and transported child pornography. He covered national security issues for the network until he resigned last year.
Court papers indicate the investigation began when the FBI received a tip from Dropbox about videos showing the sexual abuse of children in an account associated with Meek.
As part of a plea agreement, Meek admitted he used an iPhone to exchange child pornography, including a video showing the sexual abuse of an infant, during a chat session with two other individuals.
An FBI affidavit indicates that agents founds dozens of child pornography images and videos when they searched Meek’s home last year, going back to at least 2014.


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The Clemente Top will be a foundational, elevated basic in both your spring and summer wardrobe. Taking cues from classic menswear, the white shirt is made with a button-down front, boxy cut, and comfortable fit. It's super soft and made of an organic cotton blend.
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