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When Mother Nature strikes, emergency food and water is YOUR responsibility. Do you have a 3-month supply of food right now? You should. Better yet, this video shows how to start a family survival plan, with up to 1 year's worth of food & supplies!
Articles for tag: food safety, How-Tos, pantry, water
Do you really need to wash fruits and vegetables before you eat them? If so, what is the BEST method of washing produce? What about those commercial vegetable washes and produce washers you can buy... are they worth it? Here's what you need to know about washing produce -- what works and what doesn't.
Exploding glass makes great headlines, doesn't it? But what's really going on here? The truth is, there's more behind the Anchor Hocking and Pyrex exploding bakeware phenomenon than most people realize. Here are the facts.
A super handy reference guide for anyone who spends time in the kitchen cooking and preparing food. I refer to these kitchen shortcuts ALL the time!
As seen in this video, it's a proven fact that bottled drinking water is no better than tap water. Here are all the reasons you need to stop wasting money on bottled water.
Is sugar really that bad for us? Aren't sugar substitutes better? We explore these questions, while touching on the most popular artificial sweeteners used today. Here are 20 things I bet you didn't know about sugar and sugar substitutes!
This top 10 list of foods, can bring foodborne illness to your dinner table real quick. Food poisoning often starts where the product originated, or along the journey, all the way to your dinner table. If you don't clean and cook the product properly you're also responsible.
This video shows how fast you can burn microwave popcorn. The terrible smell will linger for ever and will be tough to clean. Here's the best way to get burnt popcorn smell cleaned out of your microwave.
Food mold in some cases only needs to be washed away for the item to be safe to eat. This isn't the case for Items with high moisture content as they must be thrown out.


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After suppers and the dishes were washed and put away until the next meal, everyone gathered by the small communal fire to watch her play, sing and drink her weight in wine.
The future Empress of Ming prophesied to bring endless peace to the dynasty, dressed in the drab, neutral, colorless second-hand clothing worn well past its usefulness, strummed her guqin, a five-stringed musical instrument, with a drunken smile across her face.
Between each tune, she paused long enough to chug down fermented rice wine in hearty gulps, carelessly, allowing the drops to run down her chin, and merrily singing her songs, all the while looking utterly too captivating for her good.
Such a scene was unheard of, especially from a woman of her breeding. Qing Yuan nervously twitched, fiddling in his seated position as if he had a cricket crawl up his pants. Cupping his mouth, he turned to Ye Hua and, in a hushed voice, whispered, “Ye Hua, is this behavior proper? Or should we stop her?”
Qing Yuan’s uneasy gaze reflecting his concern, and apprehension, darted to his solemn-faced friend, Ye Hua, who shrugged his slender shoulders before replying in his soft voice, “Let her be free while she can. She’s a bird whose wings will get clipped before the harem robs her essence. She’s too soft and cares more than she should. She must conceive Mo Yuan’s child immediately, only then she might endure amongst those vipers.”
Ye Hua had called her a bird, but Qing Yuan was smitten with the future leader like those she had crossed paths with on their way home. To him, she and her playful mannerisms reminded him more of a joyfully fluttering butterfly that would become encaged in a luxurious golden enclosure; nevertheless, gold, as it may be, was still a cage.
It seemed a shame, almost a sin to the cell such a free spirit, and had he not seen the disconcerting way Ye Hua often stared at her, and he had to the point it was impossible to ignore the apparent truth everyone else could see.
As a bystander, it had been downright heartbreaking to sit by and watch his dear friend suffer in silence. He knew Ye Hua was wordlessly drowning in self-contempt, engaged in a fierce internal battle of his loyalties to his brother but unable to stop himself from falling in love with his future sister-in-law. Qing Yuan wondered, was the sweetness of first love enough for Ye Hua to throw away his honor, tarnish the royal family name, and lose his twin brother’s trust? Such taboo.
His disloyal thoughts were traitorous; Qing Yuan knew his views could end with his head being separated from his neck and put on a spike. Still, if Ye Hua wanted the throne and Bai Qian as his Empress, he would support and defend Ye Hua to the end, even if his actions brought doom to his entire family. Let his bloodline be damned, his greedy, power-hungry father had already sullied their name, and he had never seen someone stare at another with such profound longing and yearning as Ye Hua did Bai Qian.
I’m conflicted. I can honestly confess that my life is currently full of strife, and I question all that was once resolute and committed. I couldn’t tell you where things began to go astray, but there’s an ongoing battle inside my head, and the closer we get to the Forbidden City, discord, this dissonant within me intensifies.
Maybe the confusion started with the baby and the earnest unyielding way she refused to leave him behind? She knew the dangers of keeping Ali near, yet she wouldn’t budge even when one of the families offered to take him from her.
If I didn’t know better and hadn’t been there when she discovered him, I would have believed she birthed him from her womb. It baffles me because I’m not a woman and lack the understanding, but how can a person be that maternal and protective to such extremes to a stranger’s child of no blood relations?
Or perhaps it was when we came upon the ruined farmers who wanted to join our caravan? I warned her of the perils and time delay, but what she said left me standing there without a decent rebuttal.
It might have been that wise expression full of true compassion when she spoke to me that stole my heart and left me breathless as she stated with conviction and a maturity deep within that didn’t match her youthful girlish face.
She declared, “We are all the same regardless of our birthright. What makes us so very different? You and I were lucky to be born into fortune with prestigious families. However, this is only one of our lives, and in the next, we might be in their tattered shoes.”
“As one of noble birth, it’s our duty, our role in this lifetime, given our advantageous circumstances. Fourth Prince, if we don’t do anything, then who will be the one to step forward and make a difference? If those in power don’t help the needy, who will?
She’s a talkative one, a real noisy chatter-box, she had too much to say for my liking, but my head dizzied and spun like a twirling top that I played with in childhood when she looked at me and smiled. I had been at a loss for words and couldn’t argue because she was right. Bai Qian was born to lead. She is the queen that will bring change for the better.
A deeper understanding revealed itself to me and I had an epiphany. Fate had nothing to do with being a leader because she is the ‘throne’ and the epitome of a sage ruler. If she’s like this now at age fifteen, I can’t even begin to wrap my head around all she will accomplish ruling by Mo Yuan’s side.
I had accepted and considered my feelings for her to be pure of genuine respect and high regard, yet that doesn’t explain the shrinking into the depths of hell misery I felt the day we ran into Minister Shao and his men finally.
They came out of nowhere surrounding the wagons, and she pretended to be a blind shaman by covering her eyes with a white cotton strip. It was brazen when she went to the man whose sole goal was to kill her and asked to read his fortune because she sensed an intense ‘royal’ aura from him. What was she thinking when she had touched his bloated, chubby face with her fingertips whispering something about a phoenix, golden throne, and sun?
Her move was bold going to him instead of running away and hiding took courage or madness. Even with her eyes covered, old Minister Shao would surely remember the face of the blind girl who hopped around and chanted some nonsensical, ridiculous remarks about his powerful male qi.
It was a spectacle as she wildly shook a branch from a nearby oak tree in their path. At the same time, Sujin played her bamboo flute offkey, causing all the birds perched in the trees above to shriek out at once loudly. This performance went on until Minister Shao angrily yelled at her for touching his face with her unworthy peasant hands and for her to get out of his way when she wished them safe passage on their journey.
Qing Yuan and I had stayed out of sight for fear that his father or one of his men would recognize us. After the close call, everyone chuckled out of relief, but not me. I wasn’t laughing. I was furious as a man possessed and it had taken every ounce of willpower within me to stay out of sight leaving her vulnerable.
Maybe that’s the reason I rushed to her and roughly yanked the strip off her face? Too roughly, I grabbed her arms and shook her slender body until she flopped like a child’s cloth doll. I yelled in her face, “Don’t you ever do that again! Do you hear me?!” I screamed, coming apart at the seams and trembling as I tore the little cotton band into shreds with my bare hands.
It was completely uncalled for and outrageous on my part, my hostile reaction was unnecessary, and I scared her so badly that she cried until she could barely open her red, puffy, swollen eyes and had the hiccups.
And I might be losing my mind. Everything damn thing Bai Qian does upsets me and gets under my skin. I’ve not met anyone who infuriates me more than she. I’ve never met anyone who makes me feel. That’s the issue at hand. She makes me feel, and what I’m feeling for her isn’t appropriate, and it’s the root of my outbursts.
My calm mannerisms have become erratic, like that day she and Sujin were playing around in the river before she pretended to be drowning. Before my brain and body connected, I dove into the water fully clothed without hesitation, and when I reached her, I clung to her for dear life because I was afraid.
I was afraid that I had lost her, and I was scared…I’m still frightened and fearful that I won’t be able to let her go when the time comes, and as of now, time is the only factor I can control, so we’re taking the most prolonged, longest roundabout way home. After all, I haven’t any choice because my heart needs more time with her before delivering her to Mo Yuan, and then she won’t be able to do my hair anymore.
I’ve never been one to wear a topknot, but when she coyly asked, blushing and hiding behind her fan, if she could do something with me that she had never done with a man, combing and fixing my hair was the last thing on my mind.
These emotions are new to me. For the first time in my life, I covet and want someone that doesn’t belong to me. This indescribable feeling must be love? It’s not my role, but I want to shower her with affection and adoration. And when in her sleep, she calls my name, and my heart yearns for her.
Ye Hua is giving me advice and considering he’s the silent type. When the quietest man of few words warns me about my unknown future, I distinctly sense that I’m entering a warzone veiled in fancy silks and exquisite perfumes, also called the Imperial Harem.
“Qian Qian, you can’t trust anyone,” Adamantly, he warns, in that low whisper-soft voice I’ve grown to adore. Unbeknownst to him, I even enjoy his grumpiness and think his sudden temper tantrums are cute.
This conversation might be the most I’ve ever heard him speaking, “Those with nothing to lose are the most dangerous. Consider everyone your enemy. Are you listening? You’ll always serve Mo Yuan on full moons when both your yin and yangs are most in harmony and whenever he flips your name tag.”
I nod my head with quick tilts before leaning down to sniff Ali’s head and reply, “Mhm, yes, Ye Hua, I heard you. All enemies and every full moon.”
I think I’m saying all the right things, but then he sighs out his mouth, exhaling as if the ground beneath us is crumbling, “This fact you must engrain in your brain. You mustn’t eat or drink anything not prepared by your staff. Mo Yuan will hand-select your servants. You shouldn’t accept gifts, cosmetics, or other trinkets because women hide musk to prevent you from becoming pregnant.”
“Yes, Ye Hua, but I was wondering. Why couldn’t you and I run away, get married, and live in a cute little cottage like the healers with Ali? We could give Ali siblings! That is unless you find me too disagreeable. Wouldn’t that be nice?”
I ask, half kidding in my coaxing voice, and how he glares back at me makes me feel instant remorse, ashamed that I brought it up. “That was a joke,” I mumble under my breath.
Purposely giggling to lighten the suddenly somber mood, I lift Ali to his grimaced crabby face repeating after him to show I value his prudent guidance, “No food, drink, gifts, and cosmetics that can make me infertile.”
Staring off at his prominent nose, chiseled jawline, shapely lips, and perfectly manly profile, I utter without thought, ever so softly that it comes out sounding like a prayer, “I hope all my children look like their father. He has such a dashing profile.”
To be continued…

domain: artistic


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China-built Belt and Road Initiative (BRI) railway project in Bangladesh is nearing completion and is set to be inaugurated in October. The project, funded by China, aims to improve connectivity and trade between China and Bangladesh.
The railway will provide a faster and more efficient mode of transportation, benefiting both countries economically. The railway is a symbol of cooperation between China and Bangladesh and a testament to the growing importance of the BRI in enhancing global connectivity and promoting economic development. The inauguration in October will be eagerly awaited and celebrated as a major achievement for both nations.
China-built BRI railway in Bangladesh project
The BRI railway in Bangladesh is an ambitious venture that aims to connect the capital city of Dhaka with the southwestern city of Jessore. The 169-kilometer railway line will also include a 6.63-kilometer tunnel under the famous Padma River, making transportation more efficient and convenient.
This project, part of China’s Belt and Road Initiative, will bring immense benefits to Bangladesh. It will facilitate the transportation of goods and people, contributing to the growth of trade and commerce in the region. Improved connectivity will also enhance tourism and promote cultural exchange between different areas of the country.
The China-built BRI railway in Bangladesh project is a demonstration of the growing partnership between China and Bangladesh. It showcases China’s commitment to investing in infrastructure development and fostering economic cooperation with its neighbouring countries.
As the October inauguration approaches, anticipation is building for the completion of this significant project. The BRI railway in Bangladesh is set to transform transportation and connectivity in the country, providing a solid foundation for future economic growth and development.
The China-built Bangladesh Railway Network, a major component of the Belt and Road Initiative (BRI), is set to be inaugurated in October. This railway project aims to improve connectivity and boost economic growth in Bangladesh. The construction of this railway line is a result of the historical context and rationale behind the BRI. China’s investment in infrastructure projects across Asia, including the railway in Bangladesh, is aimed at strengthening trade and economic ties between countries.
The BRI is a long-term initiative that seeks to enhance regional connectivity and foster cooperation between participating nations. The completion of the China-built BRI railway in Bangladesh will provide a significant transportation infrastructure boost for the country, opening up new opportunities for trade and development.
China-built BRI railway in Bangladesh infrastructure and features
The highly anticipated China-built railway project in Bangladesh is set to be inaugurated in October. This infrastructure initiative is part of China’s ambitious Belt and Road Initiative (BRI), which aims to enhance connectivity and trade between Asia, Europe, and Africa. The railway will span approximately 160 kilometres, connecting the capital city of Dhaka with Payra Port in the south.
The project’s key features include the construction of 107 kilometres of elevated tracks, 17 kilometres of underground tunnels, and 18 bridges. It is expected to significantly improve transportation efficiency, reduce congestion, and facilitate the movement of goods and people. The China-built BRI railway in Bangladesh will also stimulate economic growth, create job opportunities, and enhance regional integration.
Moreover, the railway project incorporates modern equipment and advanced technology to ensure safe and reliable operations. It will be equipped with state-of-the-art signalling systems, electrification, and rolling stock. These features will not only contribute to the overall efficiency of the railway but also promote sustainable development and environmental preservation.
The inauguration of the China-built BRI railway in Bangladesh signifies a major milestone in the country’s transportation infrastructure development. It is expected to transform the way people and goods move within Bangladesh and strengthen international connectivity. This project further establishes China’s commitment to fostering cooperation and economic development through the Belt and Road Initiative.
The economic and social advantages of the railway for Bangladesh
The upcoming inauguration of the China-built Belt and Road Initiative (BRI) railway in Bangladesh marks a significant milestone for the country’s infrastructure development. This railway project is expected to bring several benefits and implications for Bangladesh.
From an economic perspective, the BRI railway will enhance trade connectivity not only within Bangladesh but also with other countries in the region. By improving transportation efficiency and reducing costs, it will facilitate the movement of goods and boost trade volumes. This could potentially attract more foreign investment, stimulate economic growth, and create job opportunities for the local population.
Moreover, the BRI railway will enable better access to markets and resources, particularly for industries located along its route. It will provide a reliable and efficient transportation channel for both imports and exports, ensuring smoother supply chain operations.
In terms of social advantages, the railway will enhance connectivity and accessibility for the people of Bangladesh. It will connect rural areas to major cities, improving mobility and facilitating easier access to education, healthcare, and other essential services. This infrastructure development will also contribute to the overall development and integration of different regions within the country.
The China-built BRI railway in Bangladesh holds significant potential for economic and social progress. It demonstrates the importance of international collaborations in infrastructure development and presents promising opportunities for the country’s growth and development.
Potential Challenges and Concerns Associated with the Railway Project
The China-built railway project in Bangladesh, known as the Bangladesh-China-India-Myanmar Economic Corridor (BCIM-EC), is set to be inaugurated in October. While the project brings numerous benefits and opportunities, there are also potential challenges and concerns to address.
One of the concerns is the environmental impact. The construction of railways often involves land acquisition and clearance, which may result in habitat loss and biodiversity deterioration. It will be crucial to ensure the project is carried out with proper environmental assessments and mitigation plans in place.
Another challenge is the issue of local employment and skill development. While the project will create job opportunities, it’s essential to ensure that local communities have fair access to these jobs and are equipped with the necessary skills for employment.
Additionally, the railway project’s long-term sustainability is an important consideration. Proper maintenance and monitoring will be key to ensuring the railway remains operational and efficient in the years to come.
Overall, while the China-built railway project in Bangladesh presents significant economic and developmental prospects, it is crucial to address these challenges and concerns to ensure sustainable and inclusive growth for the country.
The scheduled October inauguration and future plans for the railway
The China-built Bangladesh Railway Line is set to be inaugurated in October, marking a significant milestone in the country’s infrastructure development. The railway, which stretches from Dhaka to Payra, is expected to enhance connectivity and trade between the two cities.
The project, constructed under China’s Belt and Road Initiative (BRI), aims to boost economic development and promote regional cooperation. With a length of approximately 170 kilometres, the railway line will facilitate the transportation of goods and passengers, reducing travel time and improving efficiency.
In addition to the October inauguration, future plans for the railway line include further expansion and connectivity to neighbouring countries. This expansion will open up opportunities for increased trade and economic integration in the region.
The China-built BRI railway in Bangladesh is expected to provide immense benefits for the country, such as improved connectivity, job creation, and overall economic growth. It represents a significant step forward in enhancing regional connectivity and fostering cooperation between China and Bangladesh.
Overall, the October inauguration of the railway line marks a positive development for Bangladesh and highlights the continued efforts to strengthen infrastructure and promote economic growth in the region.
Impact of China-built BRI railway in Bangladesh on international relations
The China-built BRI railway in Bangladesh, set to be inaugurated in October, is poised to have a significant impact on international relations. This infrastructure project is part of China’s ambitious Belt and Road Initiative (BRI), which aims to enhance trade connectivity and foster economic development across Asia and beyond.
The railway will not only facilitate the transportation of goods and people, but it will also deepen bilateral ties between China and Bangladesh. The project showcases China’s commitment to investing in and supporting infrastructure development in other countries. It demonstrates their willingness to forge strong partnerships and contribute to the advancement of their global economic agenda.
Furthermore, the China-built BRI railway will enhance regional integration and cooperation. By connecting Bangladesh with neighbouring countries, including India and Myanmar, will promote trade and cultural exchange, bolstering economic prosperity and stability in the region. It has the potential to create new opportunities for businesses, facilitate tourism, and strengthen people-to-people connections.
The inauguration of this project signifies a significant milestone in the bilateral relationship between China and Bangladesh. It lays the foundation for closer economic cooperation and strengthens the ties between the two nations. It also reinforces China’s position as a key player in regional development and highlights the potential benefits of participating in the Belt and Road Initiative.

domain: economics


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Meat consumption in the U.S. has grown substantially since 1969, but the amount of land devoted to growing the crops to feed cows, pigs, and chickens has dropped by nearly a third. In 1969, the average American consumed about 82, 54, and 47 pounds of beef, pork, and poultry respectively for a total of 183 pounds of meat annually. By 2016, per capita consumption of meat had risen to 213 pounds, consisting 55, 50, and 108 pounds of beef, pork, and poultry respectively. Collectively Americans ate about 15 million tons of meat in 1969 and 24 million tons in 2014. Despite the per capita increase in meat consumption along with the growth of population from 202 million to 324 million, farmers are using less cropland to grow feed for meat animals, according to Rockefeller University analysts Jesse Ausubel and Iddo Wernick in their new article, "The Shrinking Footprint of American Meat."
Ausubel and Wernick calculate that these shifts in consumption and improvements in agricultural efficiency has actually reduced the area of cropland devoted to producing animal feed since 1969 by around 9 million acres. That's an area equivalent in size to the state of Maryland. Between 1969 and 2010, they report:
Population and GDP per capita grew at annual rates averaging about positive 1% and 1.7% respectively over this period. In contrast, the same interval saw negative annual changes in the amount of meat Americans ate per dollar, the amount of grain needed to produce a unit of meat, and the amount of land needed to grow that grain. On average, between 1969 and 2010, the amount of US cropland used to grow meat fell almost 0.8% per year.
The shift in taste away from red meat toward poultry helped. By one estimate, it takes about 2.5 pounds of grain to grow one pound of chicken; 3.5 pounds for a pound of pork; and 6 pounds of feed to produce a pound of beef. Increased agricultural efficiency played a significant role too. For example, corn yields in 1969 averaged 86 bushels per acre; last year corn yields per acre averaged 171 bushels.
Start your day with Reason. Get a daily brief of the most important stories and trends every weekday morning when you subscribe to Reason Roundup.

domain: agronomy


Gospel musician, Kwaku Gyasi has revealed in a new interview with Amansan Krakye on GBC Radio Central that there’s nothing wrong in doing menial jobs outside for a living.
Kwaku Gyasi said it’s so wrong for Ghanaians to be mocking their friends and family members who wash bowls as a source of livelihood when they travel outside to seek for greener pastures.
He contended that so far as the person is engaging in a legal activity, there’s nothing wrong with that.
He also reminded his detractors that he never washed bowls in Canada during his stay that as it was speculated. He said;
“I want every Ghanaian to understand that if someone has gotten the opportunity to travel abroad and even if things have become difficult to the extent that the person makes a living out of washing cooking utensils, so far as the person doesn’t steal, I feel that is much better.
“Because the Bible says that the hands that don’t work shouldn’t eat. We should have a positive mindset and stop making a mockery of those abroad who do petty jobs to survive.
“However, when I was in Canada at first, I was washing utensils until later on I got the opportunity to further my education and because I’m gifted with the ability to play musical instruments,” Gospel Musician, Kwaku Gyasi added.


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251 W Mountain Rd, Simsbury, Connecticut 06092 is the last known address of residence for Meredith. Address belongs to Hartford County. We think Emily Meredith Jacob and Joseph E Jacob were among 2 dwellers or residents ever lived at this place. Meredith has lived in the city of Simsbury, CT.
|Alter Name||Full Name||Persons count|
|Alter Last Name||Full Name||Persons count|
Age groups distribution in the Meredith's neighborhood based on thousands households located nearby.
Information updated on Sep 29, 2020

domain: geography


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Dentist in Groß Ziethen (Brandenburg) Other Cities in Brandenburg > Brandenburg > Germany
There are several Cheap dentist in Groß Ziethen and finding the right a single to work on your mouth is vital for your health. It's a very good idea to speak with several offices just before you make your final option. One can find dentist below who may be of service to you. You can find good high quality Dentistry in Groß Ziethen so long as you take your time. If you have a family you could wish to look for dentist which give great family rates for all teeth related services. In the clinics listed ahead you will be able to find a dentist for you and your family. Finding an Affordable dentist in Groß Ziethen can be tricky; it's usually a fantastic thought to get quotes from at the very least three offices prior to creating your final selection. And always bear in mind to be careful about choosing a dental office just because of the price.
Nearest Dental Hospitals (Groß Ziethen)
Grubenweg 22, Siehdichum, Deutschland
Rosa-Luxemburg-Straße 55, Velten, Deutschland
Ärztehaus, Schweriner Straße 3, Cottbus, Deutschland
Tränkeweg 11, Fürstenwalde/Spree, Deutschland
Tannenkoppelweg 10, Wittstock, Germany
Zietenstraße 12 c, Deutschland
Karl-Liebknecht-Straße 60, Cottbus, Deutschland
Wittenberger Straße 35, Breese, Deutschland
Am Glauer Hof 7, Trebbin, Deutschland
Badergasse 8, Bad Liebenwerda, Deutschland
August-Bebel-Straße 37, Strausberg, Deutschland
Goethestraße 3, Zeuthen, Deutschland
Chausseestraße 47, Deutschland
Holbeinstraße 38, Falkensee, Deutschland
Forster Straße 91, Cottbus, Deutschland
Dental Hospitals in Groß Ziethen by Category (Brandenburg)
Pediatric dentistry is the specialty of working on the mouths and teeth of children. There are a number of dentists who specialize in this type of care and are great at working with children and creating it a comfortable visit for them.
There are several orthodontics offices that can aid to restore the teeth back to their desired position by means of the use of braces and with other corrective measures. By looking through the list of dentist below you can start your search for a qualified doctor to help you correct any issues you are facing.
You will discover several emergency dentistry offices in the Groß Ziethen area that can help you instantly if you are trying to subdue a painful or damaged tooth. Broken teeth are certainly one of the most damaging and painful feelings that can affect all places of your life inside a unfavorable way.
Cosmetic dentistry is like an art type, there are dentist who can perform miracles and are helping patients fix any sort of problems which they have with their teeth that is giving them an unwanted look or setoff teeth.
A great Oral Surgeon will perform closely with you to help make sure that your experience is as painless and rapid as possible so you'll be able to return to a regular and healthful way of living and pain totally free life with no teeth issues.
Tooth decay and gingivitis are two of the leading causes for teeth loss within this country. When you take care of your teeth and get normal checkups you'll be able to steer clear of this well being risk and catch it early if it does take location.
If you are suffering from severe tooth pain, you might be the victim of nerve discomfort. This pain can be extremely painful and demands a specialist to get fixed. It's important to acquire them taken care of swift.

domain: medical


Eric Ackerman had to give a quick pep talk Saturday afternoon at Oscar J. Frazier Park.
Ackerman heard the Beaufort County 12-and-under softball all-stars he'd been coaching for about a month say they were getting nervous.
Football season in Jasper County starts this week when Ridgeland-Hardeeville High and Thomas Heyward Academy begin their official practices.
Ridgeland-Hardeeville will practice from 6:30 to 8 a.m. and 9:15 to 10:45 a.m. Friday.
Beaufort County's 12-and-under all-star softball team has to be cautious with its pitchers this week. Players are allowed to pitch only 13 innings apiece in the five-day Dixie Ponytails Traditional World Series at Oscar J. Frazier Park.
Beaufort County is one of six teams remaining in the Dixie Ponytails Traditional World Series at Oscar J. Frazier Park.
The Parks and Leisure Services all-star softball team beat Amelia (Va.) 6-3 in an elimination game Sunday. Beaufort County, the tournament host, will take on West Monroe (La.) at 5...
Rich Roberts was taking his son to junior golf tournaments around the Southeast last year when he realized something: All those events could soon turn the sport into a grind for the now 11-year-old Zach.
It's tough to be the Atlantic Coast Conference this time of year.
With everyone gearing up for football season, the ACC never seems to get the amount of publicity afforded the nation's other power conferences.


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Here at the Township, we will kick off this New Year like those in the past - with a Reorganizational Board of Supervisors Meeting. This meeting is the first Monday of every year - which is tomorrow - Monday, January 4th at 7:00 p.m. via Zoom. The agenda and Zoom instructions can be found on our Agenda Center.
In light of tomorrow's meeting, the Board of Supervisors will not meet this Wednesday. They will resume their normal public meeting schedule (1st and 3rd Wednesday of the month at 7:00 p.m.) on Wednesday, January 20th.

domain: news


text:
PDI Sani-Cloth® Bleach Germicidal Disposable Sanitizing wipes - Large 75 Wipes Per Canister - 180 Canisters
PDI Sani-Cloth® Bleach Germicidal Disposable Sanitizing wipes - Large 75 Wipes Per Canister
You are buying 180 Canisters of Sani-Cloth Bleach® Germicidal Disposable Wipes at $21.4 per Canister.
The number one disinfecting wipe in healthcare.
Sani-Cloth® disinfecting multi-surface wipesare proven effective against a wide spectrum of viruses and bacteria including both the cold and flu viruses and common bacteria like salmonella, E. coli, and MRSA. All Sani-Wipes®are on theEPA list for use against COVID-19.Fast contact time allows for a quick room turnover. Ideal for daily use in fast-paced environments that require short contact times and broad coverage of microorganisms. Protect your facility, employees and guests during cold and flu season and disinfect commonly touched areas with Sani Professional Disinfecting Multi-Surface Wipes®.
Effective against 50 microorganims, includingClostridioides difficile, Norovirus and 14 multi-drug resistant organisms
Thick, strong wipe has high fluid capacity and is pliable to get into crevices and corners of equipment
Formula: 1:10 Dilution of 6300 PPM Sodium Hypochlorite (Bleach)
Up to 2x greater compatibility vs competitors with materials used in healthcare.
No visible degradation on stainless steel, ABS plastic, brass alloy, and more
20% extended equipment life compared to competitors
Healthcare Use Sites :
May be used on hard nonporous surfaces of bed railings, blood glucose meters (glucometers), cabinets, carts, chairs, counters, dental unit instruments trays, exam tables, gurneys, isolettes, IV poles, stethoscopes, stretchers, tables, telephones, toilet seats, diagnostic equipment, patient monitoring equipment, patient support and delivery equipment, and many more!

domain: health


Mass media has developed immensely during the last century and continues to develop right this moment. This is a most informative hub and important to writers starting out right here on HubPages like me. As an aside I learnt that you simply must be from the USA as all your credible sources are from there and I guess hornswoggled is an American colloquialism – appears like a cowboy expression: I find it irresistible. Blackberry Bold is one of the most media-friendly release yet with the inclusion of Wifi which lets you access the Internet from nearly thousands and thousands of locations worldwide (the GPS and mapping features can assist you find a web site). Some newspapers promote it by the column inch, others promote it as a fractional portion of the web page.
NHL® – Official National Hockey League website online – consists of news, rosters, statistics, schedules, groups, features, live recreation radio broadcasts and video clips. Depending on a person’s life experiences and viewpoints, it is a good bet anyone can discover bias in any information article – as a result of, actually, everyone is biased to some extent, whether they comprehend it or not. If you’re on the lookout for some sites like Reddit to maintain up with all the information, Newsvine should be your greatest bet.
In Scandinavia, Engebretsen (2006) found that on-line newspapers used a bit extra multimedia, however still not more than present in earlier studies in the United States. But it’s getting better — former content mill” sites are nice-tuning themselves by producing more correct and credible articles. It is essential that we know, determine and observe how these Internet Media.
This site is a neighborhood based news aggregator the place members submit hyperlinks to tales and content material they discover all over the Internet. This research research six UK news websites and screens how specific information stories are broken and updated throughout the course of a day. The knowledge supported the hypothesis that increased internet use has anegative effect on social involvement and psychological effectively-being. At the identical time, people began to publish video of unusual noises within the air like groans and metal grinding and virtually like trumpets.
Writers for the web news service Seed have been anticipated to make use of the system first, whereby the price of a written article wouldn’t be greater than $25 due to increased production. I for one is not going to vote for or coooperate with any politician or anybody else that has an issue with me getting all my news from Fox News or Conservative discuss radio or the web. In some instances we had been paying for channels that went towards our private beliefs and way of life, and would never have financially supported if given a selection.


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ÍslandFoldable map of Iceland with a little dictionary (Icelandic-German) in the right bottom corner. The words I chose cover some of my most typical impressions during my stay in Iceland in summer 2014. On the reverse side there are illustrations to the chosen Icelandic words, spread over the map of the island, which shines through the thin, semi-transparent paper.The Icelandic landscape is dominated by natural forces and the rough and strong structures of stones and glacial ice. My hands got also rough, therefore I used the prints of the rough skin of my hands for many parts of the pictures.
Techniqueguache hand prints, digital collage, pencil drawings
printed on an offset press


my engine gave out and dealer replaced it. Is it possible for 2008 engine to be put in a 2009 Liberty?
I did my oil change now, and the oil filter for 2009 Jeep Liberty did not fit. The filter was Mopar 4781452BB which are used for 2008 Liberty (I think fits 2002-08 models). The reason I'm asking is I have a kick/knock when driving around 50mph in a slight incline or having slight acceleration at that speed. When I checked with my local mechanic, he said this might be due to ignition coil/cable problem (seems it hasn't been replaced along with the engine) or fuel related. He asked me to use a cleaner and it didnt rectify it.
I checked in Mopar site and the ignition coil for 2008 & 2009 are different. Before I go the dealer, I want to be sure. The dealer rep wont even get up unless I consent to a $140 diagnostic charge for anything/everything. For ex, when I first went to the dealer abt the kick/knock, his response was "there is no way an engine can make noise, it has to be your transmission. It will be a $140 to check and leave the vehicle we will check in 3 days". Thats I went to the mechanic


Orders Close November 15th at 10:00 AM
All orders will be delivered in bulk to the school after orders have closed. Please allow 2 weeks for delivery.
All orders will be distributed by the Cardinal Key Honor Society.
Embroidered 1/4 Zip Jacket
- 100% polyester
- Cadet collar
- Tag-free label
- Taped neck
- Dyed-to-match Vislon zipper and pull
- Silver zipper tape
- Angled chin guard for additional comfort
- Set-in sleeves
- Open cuffs and hem


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Rolling PapersAtlantic 16099910 #ad - 2011 release, the third album from R&B rapper Cameron Jibril Thomaz, more commonly known as Wiz Khalifa. The track refers to the colors of the Pittsburgh Steelers - a football team from Wiz Khalifa's hometown. Wiz khalifa rolling papers. The album includes the first single 'Black and Yellow', produced by Grammy winning team Stargate Rihanna, Beyonc and Katy Perry.
Wiz khalifa was recently named MTV U. S's hottest breakthrough mc of 2010, beating acts such as Nicki Minaj and J Cole.
O.N.I.F.C.Atlantic 25832669 #ad - O. N. I. F. C. Wiz kicked off 2012 with a high-profile campaign with Bing, where he was featured in the search engine’s nationwide commercials. Is the follow-up to wiz khalifa’s gold-certified major label debut, and spawned the multi-platinum hits “Black And Yellow, which was released in March 2011, Rolling Papers, ” “Roll Up” and “No Sleep.
Wiz earned himself two nominations at this year’s grammy awards thanks to his breakout hit “Black And Yellow, ” in both the “Best Rap Song” and “Best Rap Performance” categories. Khalifa then joined forces with snoop dogg for “mac and Devin Go To High School Soundtrack, ” the collaborative soundtrack album for the film “Mac And Devin Go To High School.
O.N.I.F.C. #ad - The album featured the hit single “Young, Wild & Free feat. Shrink-wrapped. Wiz khalifa rolling papers. Bruno mars, ” which has gone on to become 3x-certified Platinum, and has peaked at #7 on Billboard’s Hot 100 singles chart.
Hollywood's BleedingRepublic #ad - Shrink-wrapped. Shrink-wrapped. Cd wiz khalifa rolling papers.
KamikazeShady #ad - Jessie reyez 12. Good guy ft. European edition cd. Jessie reyez 13. Venom music from the motion picture Wiz khalifa rolling papers. Shrink-wrapped. Shrink-wrapped. Tracklist - 1. The ringer 2. Greatest 3. Lucky you ft. Royce da 5. 9 9. Kamikaze 10 Fall 11. Nice guy ft. Kamikaze. Joyner lucas 4. Paul skit 5. Normal 6. Em calls paul skit 7. Stepping stone 8.
Not alike ft.
Stay TrippySony Legacy 27492892 #ad - Juicy has done it again with the release of the 2013 vibrant summer hit "Bounce It" featuring Trey Songz and Wale, which VIBE calls "the new anthem for the gentleman's club. Juicy j reunited with long time collaborator and Kemosabe label head Dr. The 16 track album features a stellar line-up of collaborations with many of his peers including Wiz Khalifa, Justin Timberlake, Big Sean, Trey Songz, Pimp C, Wale, Chris Brown, 2 Chainz, Young Jeezy, A$AP Rocky, Lil Wayne, Trina, Yelawolf and Project Pat.
Stay trippy is the highly anticipated major label debut from Memphis rap legend Juicy J. From three 6 mafia to winning an oscar and coming back with one of the biggest songs of the year with 'Bandz A Make Her Dance, ' Juicy has proven that's he's the real deal. Dr. I'm super lucky to be able to work with a talent like Juicy J.
Stay Trippy #ad - Shrink-wrapped. Wiz khalifa rolling papers. Lukewiz khalifa also serves as executive producer on stay trippy, young chop, Timbaland, Crazy Mike, Lex Luger, which includes production from Juicy J as well as some of the industry's top producers including Mike Will, Baby E, I. D. Shrink-wrapped. Luke who is an executive producer on STAY TRIPPY.
Take Care Deluxe EditionCash Money 22953419 #ad - Kamikaze. Drake- Take Care. Shrink-wrapped. Shrink-wrapped. 2011 sophomore album from the Canadian rapper. The album features collaborations and production from the likes of Rihanna, Rick Ross, Boi-1da, Nicki Minaj, Andr‚ 3000, Lil Wayne, Noah 40 and others. Wiz khalifa rolling papers. Features 'headlines' and 'Make Me Proud'.
Scorpion 2 CDCash Money #ad - Shrink-wrapped. Wiz khalifa rolling papers. Shrink-wrapped. Drake will support the album with an extensive headlining tour alongside Migos, which will launch on 7/26 in Salt Lake City. Kamikaze. Drake- Take Care. This is a double cd of drake's 5th album, Scorpion, releasing on 7/13. Drake- Scorpion. Shrink-wrapped.
Mac And Devin Go To High School SoundtrackAtlantic 23914196 #ad - Drake- Scorpion. He finds an unlikely inspiration in Mac Johnson, Snoop Dogg the least achieving student on campus. He soon realizes that the only way he'll truly have a chance with her is if he finally graduates high school. In 3 weeks time, mac must cram four years of high school academics, and Devin must cram four years of teenage experience.
Director: dylan brownmovie release date: february 2012cast:Wiz Khalifa as Devin Overstreet Snoop Dogg as Mac Johnson Mike Epps Andy MilonakisTierra Marie Wiz khalifa rolling papers. Shrink-wrapped. Kamikaze. Shrink-wrapped. Drake- Take Care. Shrink-wrapped. Shrink-wrapped. Movie plot: valedictorian hopeful, devin Overstreet Wiz Khalifa struggles to pen his graduation speech when it becomes clear that all his academic overachievements have left him with little to no life experiences.
Mac And Devin Go To High School Soundtrack #ad - Mac, a 10-year senior and consummate ladies man, is smitten by the school's new substitute chemistry teacher.
Deal Or No DealIhiphop Distribution #ad - Wiz also enlists curren$y, Lavish, Kev Da Hustla, and Josh Everette as featured guest artists. After leaving Warner Bros. He has toured relentlessly and has continued to connect with his ever-growing fanbase in new and innovative ways. Drake- Take Care. This past summer he released a now classic mixtape, "Flight School, " and teamed up with Curren$y for the "How Fly" project.
Wiz khalifa- Deal Or No Deal. Tedder, johnny Juliano and Sledgren. Shrink-wrapped. Shrink-wrapped. Contributing producers include E. Shrink-wrapped. Shrink-wrapped. Wiz will continue to tour throughout the year with upcoming stops in Indiana, Philadelphia, Los Angeles, Houston, New York City, and additional cities to be announced soon.
Deal Or No Deal #ad - Dan, josh everette, Ryan M. Kamikaze. Drake- Scorpion. Records in july, Wiz's career has continued to take off independently. Deal or no deal" is a new 15-track album that displays Wiz's growth and progression as a world-class MC. Wiz khalifa rolling papers.


Word surfaced not too long ago that the NSA could have a backdoor for a specific type of encryption algorithm popularly used by developers. Today RSA Security, which offers this encryption to its customers by default in a toolkit, has sent out a notification advising those users to stop using it for the time being, as well as instructions for different options.
Said the security bulletin RSA Security posted, “Recommending against the use of SP 800-90A Dual Elliptic Curve Deterministic Random Bit Generation: NIST strongly recommends that, pending the resolution of the security concerns and the re-issuance of SP 800-90A, the Dual_EC_DRBG, as specified in the January 2012 version of SP 800-90A, no longer be used.”
Customers are being told that the BSAFE libraries, RSA DPM clients, and servers all use the Dual EC DRBG as its default PRNG, which stands for Dual Elliptic Curve Deterministic Random Bit Generation and Pseudo-random Number Generators, respectively.
This particular type of algorithm became popular in the middle of the last decade, becoming a National Institute of Standards and Technology standard back in 2007. Such inclusion as a standard is said to have resulted from the NSA itself, which reportedly created a backdoor for the algorithm and then pushed for its widespread implementation.
To further this move away from the standard, RSA Security is conducting an internal review of its offerings and changing all instances of the algorithm’s presence, something that it anticipates wrapping up next week. There will also be a change in the default for its BSAFE Toolkits, as well as algorithm updates when necessary.


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Interested in Graduate School at GMU?
Get thesis help . Look some guides.
The British Society of Criminology (BSC) has a number of Honorary Members who through their careers have demonstrated exceptional distinction and service in the field of criminology.
BSC Appointments:President, Chair of the Public Relations Committee.
This module aims to introduce students to the general principles of English Criminal Law, with particular emphasis on the essential elements of a crime, namely 'actus reus' and 'mens rea', strict, vicarious and corporate liability and the defences. But also to the nature of liability in relation to offences against the person, for example, murder, manslaughter, assault and battery, sexual offences and offences in relation to property, for example, theft, fraud and criminal damage can be analysed. This module is designed to provide students with the opportunity to develop an understanding of the relationship between criminal and civil law and introduce them to the criminal justice system.
Dr Louise WestmarlandEmail: Open University
The HSPH Registrar s Office will distribute can submit. To nominate a dissertation for the Muste rejection or acceptance of your thesisdissertation, still chapters which improve the criminology dissertation of the after your thesisdissertation has been accepted The final decision on whether a thesis, criminology dissertation. The Paper Reader will e-mail this contract. td1 border-leftnone padding-left16px table, criminology dissertation. Paper copies of your dissertation with ISBN free of charge to the TUM Docorate. TUM University Library, the Bavarian State Library and the German National Library in Frankfurt where they will be registered for library novelty and contribution of the work, as bound and signed dissertations are due on software produced as part of the thesis.
Senior Lecturer in Criminology, Sheffield Hallam University
Interests: (1) criminal process, (2) vulnerable people in the criminal justice system, (3) alternatives to prosecution and custody, (4) resettlement (5) animal abuse and (6) quantitative and qualitative research methods including research ethics.

domain: library


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WILBER – The 25th Annual Severe Weather & Family Safety Workshop at Wilber-Clatonia High School was ended with a presentation from veteran stormchaser and photographer, Jeremy Bower.
Bower and his wife own JRBStorm Photography and it is based in Lincoln.
His presentation was called “Photographing Severe Weather Safely.”
Bower would discuss his early storm chasing career, and how he grew to what he knew today. His main goal was to keep families safe while taking great shots.
This wrapped up a day that featured numerous presentations and cool inventions, like a tornado machine that was created by two Meridian students.


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UtrechtDownUnder shows contemporary art at surprising locations in Utrecht.
UtrechtDownUnder is a biennial art manifestation in which current art is shown at special venues in Utrecht. The first edition of UtrechtDownUnder took place in the historical cellars of the Oudegracht. For the second edition, the prison doors at the Wolvenplein opened for the first time to the public. This year, the art route returns to the historical site cellars.


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Royal Three Counties Show – fully booked
- Friday 14/06/2019
- 11:00am - 4:00pm
Join us for corporate hospitality with tea, coffee and biscuits on arrival followed by a delicious two course buffet lunch, as well as afternoon tea and an open bar. Included in the price is a ticket to the show, complementary show guide and forward members parking.
Royal Three Counties Show is the largest agricultural and countryside show in the Midlands. Attractions include livestock shows, equestrian competitions, tasty regional food, family entertainment, agricultural trade stands a nd large scale main arena acts, In 2019, the show celebrates its 61st year at the Three Counties Showground.
Malvern, WR13 6NW

domain: food


The Smartwool Women's NTS Micro 150 Tee is a lightweight shirt for working up a sweat in the gym and cooling down after with friends. The NTS tee is made of merino wool which allows moisture to escape and helps you avoid dreaded pit stains. An interior logo replaces itchy tags, so a lack of comfort is no issue here. Side seams give the micro tee a form fit that hugs you in all the right places. Like in the gym, or on top of a mountain.
Products on Sale are Discontinued Styles or Colors.


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Financial hardship plagued 25-year-old Geline* from Haiti. The little income she made from her roadside cosmetics stand seemed to slip through her fingers. She struggled to keep enough money on hand to buy the supplies she needed to keep her little store stocked. In addition to cash flow for her business, Geline needed money to… Read more
SALT Microfinance Solutions
Srey La noticed the SALT facilitators who ate at the restaurant beside her. It didn’t take long for her to become interested in a SALT.
Chesa arrived at the Rohingya refugee camp in Bangladesh in 2018 with few belongings and no place to call home.
His village of Uba, Nigeria, was overrun by radical Islamic Boko Haram fighters several years ago.
After receiving Bible-based business teaching and working with his local SALT group to formulate a business plan, Hanrell got a loan of $140.
SALT savings groups provide a means through which individuals and families are given a chance to escape poverty’s clutch.
All his life this Ukrainian farmer tries to make a living, growing grain on 24 acres. But Petro’s farming venture didn’t supply enough income
Our role in SALT* Microfinance Solutions is to walk beside church communities in developing countries and helping believers in these settings.
SALT Agri-Plus is teaching Ghanaians improved ways of sowing seeds and farming by using natural materials to cultivate and reduce erosion.
CAM’s goal for the SALT program is to help people properly steward the resources God places in their care—to save for future needs,
Silvia, a sixty-year-old microloan client in Nicaragua, spent years building up a small business to help provide for herself and her family.
Namibia, a country named after the Namib desert, is nestled along the west coast of southern Africa. Namibia is known for mining precious jewels and other natural resources. Inside the city limits of Windhoek, the nation’s capital, businesses thrive. In fact, Namibia is considered to be one of Africa’s wealthiest countries. Despite the economic opportunities… Read more
Before joining a savings group, Isaac did not save money. But as he invested in the SALT savings group, he was able to buy a cow.
The hand-to-mouth mindset and widespread poverty in this city make it difficult for many people to even think of saving money for the future.
Occupational training for youth is especially needed. Many people in our world have not grown up learning trades and skills.


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Regulation of Skp2 levels by the Pim-1 protein kinase.
ABSTRACT: The Pim-1 protein kinase plays an important role in regulating both cell growth and survival and enhancing transformation by multiple oncogenes. The ability of Pim-1 to regulate cell growth is mediated, in part, by the capacity of this protein kinase to control the levels of the p27, a protein that is a critical regulator of cyclin-dependent kinases that mediate cell cycle progression. To understand how Pim-1 is capable of regulating p27 protein levels, we focused our attention on the SCF(Skp2) ubiquitin ligase complex that controls the rate of degradation of this protein. We found that expression of Pim-1 increases the level of Skp2 through direct binding and phosphorylation of multiple sites on this protein. Along with known Skp2 phosphorylation sites including Ser(64) and Ser(72), we have identified Thr(417) as a unique Pim-1 phosphorylation target. Phosphorylation of Thr(417) controls the stability of Skp2 and its ability to degrade p27. Additionally, we found that Pim-1 regulates the anaphase-promoting complex or cyclosome (APC/C complex) that mediates the ubiquitination of Skp2. Pim-1 phosphorylates Cdh1 and impairs binding of this protein to another APC/C complex member, CDC27. These modifications inhibit Skp2 from degradation. Marked increases in Skp2 caused by these mechanisms lower cellular p27 levels. Consistent with these observations, we show that Pim-1 is able to cooperate with Skp2 to signal S phase entry. Our data reveal a novel Pim-1 kinase-dependent signaling pathway that plays a crucial role in cell cycle regulation.
Project description:The p27(Kip1) protein is a potent cyclin-dependent kinase inhibitor, the level of which is decreased in many common human cancers as a result of enhanced ubiquitin-dependent degradation. The multiprotein complex SCF(Skp2) has been identified as the ubiquitin ligase that targets p27, but the functional interactions within this complex are not well understood. One component, the F-box protein Skp2, binds p27 when the latter is phosphorylated on Thr(187), thus providing substrate specificity for the ligase. Recently, we and others have shown that the small cell cycle regulatory protein Cks1 plays a critical role in p27 ubiquitination by increasing the binding affinity of Skp2 for p27. Here we report the development of a homogeneous time-resolved fluorescence assay that allows the quantification of the molecular interactions between human recombinant Skp2, Cks1 and a p27-derived peptide phosphorylated on Thr(187). Using this assay, we have determined the dissociation constant of the Skp2-Cks1 complex (K(d) 140 +/- 14 nM) and have shown that Skp2 binds phosphorylated p27 peptide with high affinity only in the presence of Cks1 (K(d) 37 +/- 2 nM). Cks1 does not bind directly to the p27 phosphopeptide or to Skp1, which confirms its suggested role as an allosteric effector of Skp2.
Project description:Deregulated Skp2 function promotes cell transformation, and this is consistent with observations of Skp2 overexpression in many human cancers. However, the mechanisms underlying elevated Skp2 expression are still unknown. Here we show that the serine/threonine protein kinase Akt1, but not Akt2, directly controls Skp2 stability by a mechanism that involves degradation by the APC-Cdh1 ubiquitin ligase complex. We show further that Akt1 phosphorylates Skp2 at Ser 72, which is required to disrupt the interaction between Cdh1 and Skp2. In addition, we show that Ser 72 is localized within a putative nuclear localization sequence and that phosphorylation of Ser 72 by Akt leads to cytoplasmic translocation of Skp2. This finding expands our knowledge of how specific signalling kinase cascades influence proteolysis governed by APC-Cdh1 complexes, and provides evidence that elevated Akt activity and cytoplasmic Skp2 expression may be causative for cancer progression.
Project description:The levels of proteins that control the cell cycle are regulated by ubiquitin-mediated degradation via the ubiquitin-proteasome system (UPS) by substrate-specific E3 ubiquitin ligases. The cyclin-dependent kinase inhibitor, p27kip1 (p27), that blocks the cell cycle in G1, is ubiquitylated by the E3 ligase SCF-Skp2/Cks1 for degradation by the UPS. In turn, Skp2 and Cks1 are ubiquitylated by the E3 ligase complex APC/Cdh1 for destruction thereby maintaining abundant levels of nuclear p27. We previously showed that perpetual proteasomal degradation of p27 is an early event in Type I endometrial carcinogenesis (ECA), an estrogen (E2)-induced cancer. The present studies demonstrate that E2 stimulates growth of ECA cell lines and normal primary endometrial epithelial cells (EECs) and induces MAPK-ERK1/2-dependent phosphorylation of p27 on Thr187, a prerequisite for p27 ubiquitylation by nuclear SCF-Skp2/Cks1 and subsequent degradation. In addition, E2 decreases the E3 ligase [APC]Cdh1 leaving Skp2 and Cks1 intact to cause p27 degradation. Furthermore, knocking-down Skp2 prevents E2-induced p27 degradation and growth stimulation suggesting that the pathogenesis of E2-induced ECA is dependent on Skp2-mediated degradation of p27. Conversely, progesterone (Pg) as an inhibitor of endometrial proliferation increases nuclear p27 and Cdh1 in primary EECs and ECA cells. Pg, also increases Cdh1 binding to APC to form the active E3ligase. Knocking-down Cdh1 obviates Pg-induced stabilization of p27 and growth inhibition. Notably, neither E2 nor Pg affected transcription of Cdh1, Skp2, Cks1 nor p27. These studies provide new insights into hormone regulation of cell proliferation through the UPS. The data implicates that preventing nuclear p27 degradation by blocking Skp2/Cks1-mediated degradation of p27 or increasing Cdh1 to mediate degradation of Skp2-Cks1 are potential strategies for the prevention and treatment of ECA.
Project description:Cell cycle stimulation is a major transforming mechanism of Myc oncoprotein. This is achieved through at least three concomitant mechanisms: upregulation of cyclins and Cdks, downregulation of the Cdk inhibitors p15 and p21 and the degradation of p27. The Myc-p27 antagonism has been shown to be relevant in human cancer. To be degraded, p27 must be phosphorylated at Thr-187 to be recognized by Skp2, a component of the ubiquitination complex. We previously described that Myc induces Skp2 expression. Here we show that not only Cdk2 but Cdk1 phosphorylates p27 at the Thr-187. Moreover, Myc induced p27 degradation in murine fibroblasts through Cdk1 activation, which was achieved by Myc-dependent cyclin A and B induction. In the absence of Cdk2, p27 phosphorylation at Thr-187 was mainly carried out by cyclin A2-Cdk1 and cyclin B1-Cdk1. We also show that Cdk1 inhibition was enough for the synthetic lethal interaction with Myc. This result is relevant because Cdk1 is the only Cdk strictly required for cell cycle and the reported synthetic lethal interaction between Cdk1 and Myc.
Project description:As a subunit of a ubiquitin ligase, Skp2 is implicated in facilitating cell cycle progression via degradation of various protein targets. We report here that Skp2 is rapidly degraded following cellular stimulation by the cytokine transforming growth factor beta (TGF-beta) and that this degradation stabilizes the cell cycle arrest protein p27. The Skp2 degradation is mediated by Cdh1-anaphase-promoting complex (APC), as shown by depletion of Cdh1 with small interfering RNA, and by reconstitution of ubiquitylation reactions in a purified system. Blockage of Skp2 degradation greatly reduces TGF-beta-induced cell cycle arrest, as does expression of a nondegradable Skp2 mutant. Furthermore, we demonstrate that TGF-beta-induced Skp2 degradation is mediated by the Smad cascade. The degradation of Skp2 stabilizes p27, thereby ensuring TGF-beta-induced cell cycle arrest. These results identify a novel mechanism for tumor suppression by TGF-beta and explain why dysfunction of APC in the TGF-beta pathway in responsive cells is associated with cancer.
Project description:The p27(Kip1) ubiquitin ligase receptor Skp2 is often overexpressed in human tumours and displays oncogenic properties. The activity of SCF(Skp2) is regulated by the APC(Cdh1), which targets Skp2 for degradation. Here we show that Skp2 phosphorylation on Ser64/Ser72 positively regulates its function in vivo. Phosphorylation of Ser64, and to a lesser extent Ser72, stabilizes Skp2 by interfering with its association with Cdh1, without affecting intrinsic ligase activity. Cyclin-dependent kinase (CDK)2-mediated phosphorylation of Skp2 on Ser64 allows its expression in mid-G1 phase, even in the presence of active APC(Cdh1). Reciprocally, dephosphorylation of Skp2 by the mitotic phosphatase Cdc14B at the M --> G1 transition promotes its degradation by APC(Cdh1). Importantly, lowering the levels of Cdc14B accelerates cell cycle progression from mitosis to S phase in an Skp2-dependent manner, demonstrating epistatic relationship of Cdc14B and Skp2 in the regulation of G1 length. Thus, our results reveal that reversible phosphorylation plays a key role in the timing of Skp2 expression in the cell cycle.
Project description:During the G(1)-S transition, the activity of Cdk2 is regulated by its association with p27(KIP1), which in rodent fibroblasts undergoes phosphorylation mainly at serine 10, threonine 187, and C-terminal threonine 197 by KIS, Cdk2, and Pim or ROCK, respectively. Recently Cdc6 the AAA+ ATPase, identified initially to assemble pre-replicative complexes on origins of replication and later to activate p21(CIP1)-inactivated Cdk2, was found also to activate p27-bound Cdk2 but only after the bound p27 is C-terminally phosphorylated. On the other hand, the biological significance of the serine 10 phosphorylation remains elusive aside from its involvement in the stability of p27 itself. We report here that serine 10 phosphorylation is required for efficient C-terminal phosphorylation of its own by PIM and ROCK kinases and critically controls the potency of p27 as a Cdk2 inhibitor. In vitro, PIM1 and active ROCK1 efficiently phosphorylated free as well as Cdk2-bound p27 but only when the p27 was phosphorylated at Ser-10 in advance. Consistently, a Ser-10 nonphosphorylatable mutant p27 protein was not phosphorylated at the C terminus in vivo. Furthermore, when double-phosphorylated, free p27 was no longer a potent inhibitor of Cdk2, and Cdk2-bound p27 could be removed by Cdc6 to reactivate the Cdk2. Thus, phosphorylation at these two sites crucially controls the potency of this CDK inhibitor in two distinct modes.
Project description:p27Kip1 (p27) is an inhibitor of cyclin-dependent kinases. Inhibiting p27 protein degradation is an actively developing cancer therapy strategy. One focus has been to identify small molecule inhibitors to block recruitment of Thr-187-phosphorylated p27 (p27T187p) to SCF(Skp2/Cks1) ubiquitin ligase. Since phosphorylation of Thr-187 is required for this recruitment, p27T187A knockin (KI) mice were generated to determine the effects of systemically blocking interaction between p27 and Skp2/Cks1 on tumor susceptibility and other proliferation related mouse physiology. Rb1(+/-) mice develop pituitary tumors with full penetrance and the tumors are invariably Rb1(-/-), modeling tumorigenesis by two-hit loss of RB1 in humans. Immunization induced humoral immunity depends on rapid B cell proliferation and clonal selection in germinal centers (GCs) and declines with age in mice and humans. Here, we show that p27T187A KI prevented pituitary tumorigenesis in Rb1(+/-) mice and corrected decline in humoral immunity in older mice following immunization with sheep red blood cells (SRBC). These findings reveal physiological contexts that depend on p27 ubiquitination by SCF(Skp2-Cks1) ubiquitin ligase and therefore help forecast clinical potentials of Skp2/Cks1-p27T187p interaction inhibitors. We further show that GC B cells and T cells use different mechanisms to regulate their p27 protein levels, and propose a T helper cell exhaustion model resembling that of stem cell exhaustion to understand decline in T cell-dependent humoral immunity in older age.
Project description:Androgen receptor (AR) plays a pivotal role in prostate cancer. Regulation of AR transcriptional activity by post-translational modifications, such as phosphorylation by multiple kinases, is well documented. Here, we report that two PIM-1 kinase isoforms which are up-regulated during prostate cancer progression, namely PIM-1S and PIM-1L, modulate AR stability and transcriptional activity through differentially phosphorylating AR at serine 213 (Ser-213) and threonine 850 (Thr-850). Although both kinases are capable of interacting with and phosphorylating AR at Ser-213, only PIM-1L could phosphorylate Thr-850. We also showed that PIM-1S induced Ser-213 phosphorylation destabilizes AR by recruiting the ubiquitin E3 ligase Mdm2 and promotes AR degradation in a cell cycle-dependent manner, while PIM-1L-induced Thr-850 phosphorylation stabilizes AR by recruiting the ubiquitin E3 ligase RNF6 and promotes AR-mediated transcription under low-androgen conditions. Furthermore, both PIM-1 isoforms could promote prostate cancer cell growth under low-androgen conditions. Our data suggest that these kinases regulate AR stability and transcriptional activity through recruitment of different functional partners in a phosphorylation-dependent manner. As AR turnover has been previously shown to be critical for cell cycle progression in prostate cancer cells, PIM-1 kinase isoforms may promote prostate cancer cell growth, at least in part, through modulating AR activity via distinct mechanisms.
Project description:Temporal control of p27(Kip1) (p27) degradation imposes periodicity in its activity during cell cycle progression and its accumulation during cell cycle exit. Degradation of p27 is initiated by phosphorylation of p27 at Thr-187, which marks the protein for ubiquitination by SCF(Skp2) and subsequent proteolysis by the 26S proteasome. Here we show that the p27 ubiquitination activity in cell extracts depends on the presence of the ubiquitin-like protein Nedd8 and enzymes that catalyze Nedd8 conjugation to proteins. Moreover, we show that reconstitution of the p27 ubiquitination activity of recombinant SCF(Skp2) also requires Nedd8 conjugation pathway components. Inactivation of the Nedd8 conjugation pathway by a dominant negative mutant of the Nedd8-conjugating enzyme Nce1/Ubc12 blocks the ubiquitination and degradation of p27 in cell extracts. Consistent with a role in cell-cycle progression, Nedd8 is expressed in proliferating cells and is itself down-regulated upon cellular differentiation. These results suggest that the Nedd8 conjugation pathway may regulate the turnover of p27(Kip1), independently of p27 phosphorylation, and further establishes the identity of protein components involved in p27 ubiquitination. Finally, these findings provide a direct demonstration of a function for Nedd8 in a biological process.


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An important city of Maharashtra state, Aurangabad is known worldwide for its closeness to UNESCO World Heritage Sites - Ajanta Caves and Ellora Caves. This city got its name from great Mughal Emperor Aurangzeb.The intersections of north and south India meets here. The city lies on a major trade route which makes connection between India's sea ports to land markets of Deccan, which is known as the ‘Silk Route’. Aurangabad can be easily reached by air travel, trains or bus services. Before booking tickets for flights check the airfares across various domestic LCCs. Airline bookings can be done according to flight schedule. Aurangabad Railway Station is connected by trains of Indian Railways. Make reservations through online reservations after checking train availability and train tickets. Regular bus services connect Aurangabad to other cities of the state. Buy bus tickets directly or do bus bookings in advance for group. Online booking is also available for inter state buses including Volvo bus and sleeper bus. For accommodation plenty of cheap hotels are available in Aurangabad. On Aurangabad packages you can stay in a budget hotel or a star luxury hotel at discount rate. So, for a glimpse of the bygone era visit Aurangabad and book bus tickets with MakeMyTrip.com the largest online travel booking portal in India.
Indore, the largest city in Madhya Pradesh lies on the banks of the River Khan and Sarawati. Being the richest city in central India, Indore is famous for its rich cultural heritage and architectural splendor. Located 190 km west of Bhopal, Indore is renowned as "Mini Mumbai" among native people of Indore. The growing population of Indore includes Marathi, Gujarati, Marwari and Sindhi. Indore, a vibrant city welcomes tourists from all over world. Famous for handloom saris, textile industry of Indore has taken off to new heights. The 19th century majestic temples and other historical monuments describe the glorious history of this magnificent city. You can gain best travel experience in Indore in the period between April and December. Famous as the ‘food city’, Indore has a large number of heritage hotels which offer multiple cuisines. Further, Indore is blessed with magnificent palaces, old forts and wonderful monuments. The buses are run and managed by Madhya Pradesh State Road Transport Corporation (MPSRTC) daily. You can easily get the bus tickets from Sarawate Bus Stand in Indore for Bilaspur, Gwalior, Bhopal, Khujner, Ujjain, Guna, Daboh, Datia, Damoh, Harsud, Badnagar, Tikamgarh, Barwaha, Bhind, Seoni, Harsud, Khandwa, Habibganj, Bina, Babina and many other vital cities within the state of Madhya Pradesh. You can also get the bus tickets from Sarawate Bus Stand in Indore for Jhansi, Lucknow, Kanpur, Agra, Delhi, Chandigarh, Jaipur, Udaipur, Bikaner, Jodhpur, Ajmer Sharif, Shimla and many other cities outside Madhya Pradesh. At the same time you can get the intercity and interstate bus facility from Gangwal Bus Stand and Rau Bus Stand respectively. Madhya Pradesh State Road Transport Corporation (MPSRTC) and some private bus operator’s ply their buses from these two bus stands in Indore as well. Madhya Pradesh State Road Transport Corporation (MPSRTC) has Super Volvo, Super Fast, Express, A/C, Non A/C and Sleeper along with deluxe type of buses. Bus fare starts from 150-200 INR and may vary according to the type of bus used and the total distance traveled. You can avail all the bus tickets from “make my trip” travel partner also. There are several private bus operators in Indore that operate intercity and interstate bus facility also. Bharati Travels, Multani Sona Travels, National Insurance Co Ltd, Riddhi Siddhi Communication and Travel Services, Shatabdi Travels, Shree Khurana Travels, Akhanda Travels and Ambe travels are some of the significant bus agents in Indore. All these bus agents offer bus tickets to Bilaspur, Gwalior, Bhopal, Khujner, Ujjain, Guna, Daboh, Datia, Damoh, Harsud, Badnagar, Jhansi, Lucknow, Kanpur, Agra, Delhi, Chandigarh, Jaipur, Udaipur and many more cites respectively. Normal fare starts from 350-400 INR and you could book all the tickets from “make my trip” travel partner also.
The city is marching towards quick industrial augmentation, but retains its precedent grandeur and charms, tradition and ethnicity. Noticeably seen on the Deccan plateau, it has affluent customs and an overabundance of outstanding arts on display. Aurangabad is well-known for its Historic gates. There are thirteen gates which still stand with pride and have become the featured part of the city. These are Barapulla Gate, Bhadkal Darwaza, Delhi Gate, Kala Darwaza, Khas Gate, Khizer Gate, Makai Gate, Manju Gate, Mehmood Darwaza, Naubat Darwaza, Paithan Gate, Rangeen Darwaza and Raushan Gate.
Things To Know About Indore
A pre-dominantly commercial city, Indore has a relatively laid back lifestyle, offering an opportunity for a relaxing holiday. While the city itself boasts of numerous historical monuments and other tourist attractions, it is also a base for excursions to nearby towns that are ideal holiday destinations. These include highly revered religious destinations like Omkareshwar (77 km) and Ujjain (36 km) as well as ancient historical towns Maheshwar (91 km) and Mandu (99 km). All these places are easily accessible by road. Regular bus services are offered by state transport department as well as private operators. While bus tickets are available at the bus stand, bus bookings should be done in advance to avoid last minute hassles.
More About [node:field-bus-src-city] [node:field-bus-dest-city] Buses
We errnously book seater then we request to sleeper but they never give us. We booked the 20th May 2016 that time ticket charges 1500 pp and after 1 week ticket are showing lesser rate.even bus operat...
Quality (3) | Behaviour (3) | Punctuality (3)
Vivek Bhalerao | Jun 05,2016 for Paulo Travels
The overall trip was very comfortable and nice.
Quality (5) | Behaviour (5) | Punctuality (5)
Gayatri Toshniwal | May 31,2016 for Konduskar Travels Pvt. Ltd.
Book Aurangabad to Indore Bus Booking with MakeMyTrip. Bus ticket at Lowest Fares - Big Discounts on Bus! Get discount upto Rs.120 use code BUS120 Hurry! Book Now Also find routes, distance, restaurants near boarding points & time to reach there.

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266 Items Tagged
Your poop is a window into your health.
Do you need to reset your gut health?
I call this the "Wellness Trifecta."
What happens in your gut doesn't stay in your gut.
If all disease begins in the gut, as Hippocrates once said, then so does healing.
Don't let this type of protein disrupt your digestion.
Dr. Amy Shah, a functional medicine doctor, explains why she recommends intermittent fasting to her patients, and shares how to do it effectively.
As a nutritionist, I always consider the health of the gut and microbiome when working with clients. Those friendly bugs living in our guts have a...
A successful weight-loss plan isn't just about the ratio of protein, fat, and carbohydrates. New research shows that our microbiome plays a pivotal...
The importance of your skin health goes beyond beauty.
Dr. Amy Shah, MD, an expert in gut health, shares the types of foods and supplements that could help you heal your gut.
As a functional medicine doctor, I often see my patients' stress contribute to candida, or an overgrowth of yeast in the gut. Here's how to avoid it.
Your microbiome is your key to weight loss success. Here's how to feed it the right way.
Research shows that factors besides diet and physical activity can contribute to weight gain, including environmental toxins and changes in your...
As an integrative neurologist, I'm fascinated by the connection between the brain and gut. And what I’ve found after working with thousands of...

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W-6 / Body-Mind Centering: Dance of the In-between Spaces
In the frame of Winter Tanz 2016/17
Movement starts in every cell of our inner spaces. From there it develops and manifests itself in the outer spaces. We go into detail, we focus inwards to explore the continuum of movement between the inner spaces of our body: between heart and vessels, between vertebra and sternum, between ribs and esophagus, between fascia and fat. Discovering these unconscious spaces in our body and releasing their hidden forces will help us to find more joyful and released dancing.
Lambrini Konstantinou, dancer, choreographer, dance pedagogue, Body-Mind Centering ® practitioner and teacher; Certified Movement Analyst; Osteopath focussing on Craniosacral and Pediatric Osteopathy; Somatic Experiencing-Trauma Healing. Lambrini combines anatomical knowledge with movement meditation, bodywork, dance and creative expression. The fulcrum (centre) of her work lies particularly in the cross-referencing of these disciplines, which regard the body as a unity of soma, mind and soul and approaching each other through researching structure and function of the tissue. All of this happens in the continuum of micro and macro, internally and externally as well as in the artistic expression of the body as a whole, both in silence and movement.


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It’s now reported that Milan have agreed terms with both Sevilla and Carlos Bacca for €30m. “He is very happy.”
This evening the Colombia international’s agent confirmed to several sources, including Calciomercato.com, Milannews.it and Sky Sport Italia, that Bacca had a deal with the Rossoneri.
“I can confirm that Milan and the player reached an agreement,” representative Sergio Barila told MilanNews.it.
“Carlos chose what is best for his future, so it’s only natural he is happy.”
According to Sky Sport Italia, just a couple of hours later the two clubs also agreed terms for the €30m transfer, to be paid over several instalments.
CEO Adriano Galliani rushed to a meeting with Sevilla director of sport Monchi and they quickly reached a positive conclusion.
As Colombia went out of the Copa America last night on penalties against Argentina, 28-year-old Bacca is available to fly in for a medical.
The transfer could well be completed within 24 hours.
It’s believed to be a five-year contract starting at €2.5m per season, rising to over €3m plus bonuses.
Watch Serie A live in the UK on Premier Sports for just £11.99 per month including live LaLiga, Eredivisie, Scottish Cup Football and more. Visit: https://subscribe.premiersports.tv/

domain: sports


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2022 South Coast Plaza Walking Tour [4K] | Lunar New Year Celebration | Costa Mesa California appeared first on Exclusive Discount.
South Coast Plaza
South Coast Plaza is a regional shopping mall in Costa Mesa, California. The largest shopping center on the West Coast of the United States, its pre-COVID sales of over $1.5 billion annually were the highest in the United States. Its 275 retailers represent the highest concentration of design fashion retail in the U.S., with the second highest sales-volume in California at $800 per square foot ($8,600/m2)—second only to Westfield Valley Fair in San Jose-Santa Clara, at $809 per square foot ($8,710/m2).
originally published at Retail - Exclusive Discount


After Donald Trump shocked the country by actually doing what he said he was going to do, namely, win the election, the hair-pulling, teeth-gnashing, screaming, crying and all-around hysteria began. Hollywood folk filmed videos imploring the country to resist this evil man. Women started crafting little pussycat hats out of yarn in a brave and moving attempt to show that they could knit their way out of bondage. Other women vowed to converge on the capital the day after Lucifer was inaugurated in an attempt to show that they, too, have a dream that the man with the orange hair would just disappear. Black Lives Matter supporters started yammering about how they’d take back the country from white supremacists. Young people, including those at my alma mater Bryn Mawr, started marching for civil rights, demanding that the old, decrepit establishment types take notice and listen to the “youthquake” happening around the country (one that was not strong enough to anoint Bernie but hey, never mind as Emily Litella would say). Gays and lesbians and transgenders and bisexuals and asexuals started talking about how they would not be shoved back into that extremely crowded closet with the rank societal mothballs. Disabled people reminded all of us, and rightly so, that the president-elect had mocked one of their own on television.
The Resistance was forming, and it was loud, and it was proud, and it was beautiful.
But apparently, it was too busy patting itself on the back to notice when an actual, identifiable, real-and-not-imagined hate crime was committed in Chicago this week.
A young mentally challenged man was kidnapped and tortured by four people, and the ordeal was filmed and then uploaded to Facebook.
The crimes were committed by people of color, who, if you asked them, probably support Black Lives Matter. Half of the attackers were women, who probably took knitting classes to figure out how to make one of those pussycat hats, and who might have already bought their tickets to the Million Woman March on D.C. We don’t know the sexual orientation of the thugs (because film doesn’t lie and what we saw on film was thuggish behavior so they’re not “alleged” thugs) but we do know that they hated Donald Trump, that evil, racist, homophobic, xenophobic misogynist because while they were beating the disabled man on the head and over his torso and on his arms and legs with barely disguised and almost orgasmic glee, they used his name interchangeably with the “F” word. And I don’t mean “federalist.”
So, then, we have people of color, including women, attacking a disabled man and screaming expletives because a man who will violate the civil and human rights of people of color, women, disabled people and all other sorts of minorities will be our next president. Oh, I forgot to mention one thing. The victim was white, and again, the attackers were people of color. That color was brown.
If you haven’t yet grasped the irony of this situation, you really have to stop drinking so much on Saturday evenings. This is a hate crime of the purest distillation, an example of how witch hunts are started and humans are reduced to bestial messes. These four individuals, young people by the way, members of the social media generation that likes to film its sadistic acts and share them with likeminded creatures, are the prototypes of every “protected group” that slithered out of their safe spaces for a few moments to scream about the horrific acts that would be visited upon them and their brothers and sisters if Donald Trump became president.
And then, they didn’t even wait for a couple of weeks before he actually took the oath of office with, apparently, only Sanjaya from “American Idol” performing in his honor, before they allowed their basest and most inhuman instincts to take over. They did exactly what they supposed Donald and his supporters would do, terrorize a vulnerable person because of personal animus.
Normally, I do not like hate-crime legislation. In fact, I have been a rather vocal opponent of it, as recently as this past week. I do not like having specific groups carved out for special protections because we presume that someone has decided to hurt them because of their “identity.”
But there are certain special exceptions that I will make to this rule, and these four young people of color, two of whom are women and all of whom tortured a disabled person, are exactly the sort of people who deserve to benefit from that exception.
Yes, give them due process. Yes, give them a fair trial. Yes, provide them with the finest defense that the ACLU and other uber-sympathetic progressives can design. Yes, listen to their excuses that they were misunderstood, underprivileged, beaten down by the racism and sexism that President Trump fomented (even though he wasn’t president yet when they decided to violate the human rights of their white, disabled victim). Yes, listen to the pundits who will do some version of the lament to Officer Krupke, as in, they were depraved because they were deprived.
Yes, do all of this, and make sure that we are duly respectful of the feelings of those nestled in their delicate Faberge eggs.
And then convict the hell out of them, because film doesn’t lie.
My suggestion for a punishment? Internships at the White House. Unpaid, of course.
Christine Flowers is an attorney and Delaware County resident. Her column appears every Sunday. Email her at firstname.lastname@example.org.


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The study entitled “Efficacy of Tank Mixed Herbicides with Insecticides in Growth and Yield of Soybean (Glycine max.
(L.) Merrill)” was conducted in rainfed condition under “All India Co-ordinated Research Project on soybean at R.A.K. College of Agriculture, Sehore (M.P.), during Kharif
2014.Experiment was laid out in randomized block design with three replications. The treatments included rynaxypyre 20SC 120g a.i./ha, indoxacarb14.5SC 87g a.i./ha, quinalphos 25EC 150ga.i./ha, imazethapyr10SL 100g a.i./ha, quizalofop-p-ethyl 5EC 50g a.i./ha, rynaxypyre 20SC120g a.i./ha + imazethapyr10SL 100 ga.i/ha, rynaxypyre 20SC120g a.i/ha + quizalofop-p-ethyl5EC50ga.i./ha, indoxacarb14.5SC 87g a.i./ha+imazethapyr10SL 100g a.i./ha, indoxacarb14.5SC 87g a.i./ha +quizalofop-p-ethyl 5EC 50g a.i./ha, quinalphos 25EC150g a.i./ha + imazethapyr10 SL100 g a.i./ha, quinalphos 25EC150g a.i./ha + quizalofop-p-ethyl 5EC 50g a.i./ha and untreated check. Among the monocot weeds Echinochloacrusgalli Link, Degiteriasanguinalis, Dinebraarabica, Cyperusrotundus Linn
. And Commelinabenghalensis
while the dicot weeds Acalypha indica Linn, Eclipta alba, Caesuliaaxillaris Roxb., Digeraarvensis, Corchorousacutangulus
were observed in the field. Application of indoxacarb14.5SC 87g ai/ha + imazathapyr10SL 100g ai/ha gave lowest weed dry weight and higher weed control efficiency(75.03%).Application of imazathapyr10SL 100g ai/ha alone or in combination with insecticides viz. indoxacarb, rynyxypyre and quinolphos recorded less weed dry biomass and increased weed control efficiency, imazathapyr controlled both dicot and monocot weeds. Application of quizalofop-p-ethyl5EC 50g ai/ha alone and in combination with insecticides effectively controlled the monocot weeds especially grasses viz. Echinochloacrusgalli Link. Degiteriasanguinali
. In growth attributing characters of plants application of indoxacarb 14.5SC87g ai/ha + imazathapyr10SL 100g ai/ha gave significantly higher plant height, branches per plant, plant dry weight, at all observation stages of crop. The pods per plant, seeds per pod, grain yield per plant and seed index were higher in combined application of indoxacarb14.5SC 87g ai/ha + imazathapyr10SL 100g ai/ha followed by rynyxypyre20SC 120g ai/ha + imazathapyr 10SL 100g ai/ha. The seed yield (1.89t/ha) was significantly higher with application of indoxacarb14.5SC 87g ai/ha +imazathapyr10SL 100g ai/ha than all treatments except application of rynyxypyre20SC 120g ai/ha + imazathapyr10SL 100g ai/ha (1.69t/ha).


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Awareness: Mental Health Facts
Hone your Awareness
- 15% of the world’s population (1.1 billion people) had a mental illness in 2016.
- It is expected that 45% of us will experience a mental illness in our lifetimes.
- 20% of Australians were experiencing a current and chronic mental health or behavioural condition prior to Covid-19. The figures are expected to rise significantly.
- Current treatment options are inadequate: typical treatments work for only about 35% of people with mental illness, and even when they do, most continue to experience some symptoms, and most relapse within the first year or two after treatment stops.
- In Australia, mental illness is the leading cause of non-fatal disease burden, and the third leading cause of total disease burden.
- The direct cost of mental illness in Australia is at least $60 billion annually with indirect costs amounting to $180 billion annually, prior to the Covid-19 pandemic.
- Well-designed clinical trials with psychedelic-assisted psychotherapy have produced impressive results, demonstrating their potential to be a game-changer for mental health treatment.
Get real with the current state of mental health in Australia and around the world.
Global mental illness - prevalence and burden
Share of population with mental health and substance use disorders, 2016
Australia mental illness - prevalence and burden
In 2017-18, one in five (4.8 million) Australians aged 16 to 85 had a current and chronic mental health or behavioural condition[vi]. This number has been steadily increasing, up nearly 3% from the 2014-15 National Health Survey. At least 45%[vii] of Australians will experience a mental illness in their lifetime[viii].
The most common mental illnesses in Australia are depression, anxiety, and substance use disorders (often occurring together). In a single year, 13% of Australians will be diagnosed with an anxiety-related condition (e.g., post-traumatic stress disorder, social phobia), 10% with a depression-related condition[vi], and over 5% of Australian adults generally[ix], and 13% of people aged 16-24, will be diagnosed with a substance use disorder[x]. Diagnoses aside, in 2017-18, 13% (2.4 million) of Australians reported high or very high levels of psychosocial distress over the past 4 weeks alone[vi].
Mental illness in Australia – Harms
In 2011, mental illness was responsible for 12% of the total disease burden in Australia (years of life lost and years of life lived with disability, combined), behind only cancer and cardiovascular disease[xi]. When considering only years lived with disability (non-fatal disease burden), mental illness was the leading cause.
An estimated 200 Australians attempt to take their life each day[xii], and the suicide rate in Australia has been steadily on the rise over the past decade. Suicide is the 13th leading cause of death – over 3,000 Australians take their life each year, or 8-9 people each day[xiii]. The more prevalent causes of death are attributable to factors largely associated with old age, with median ages of death for these causes typically in the 80s – the median age for suicide is 45 years. Mood disorders (including depression and anxiety) are the leading cause of suicide, accounting for 43% of Australian suicides in 2017-18[xiii].
Mental Illness in Australia – Costs
Mental Illness Treatment
To date, psychedelic-assisted psychotherapy research has shown early yet strong clinical results, particularly for disorders of depression, anxiety, addiction, and obsession. Psychedelics and MDMA are incredibly safe compared to other substances. MDMA-assisted psychotherapy (not a classical psychedelic, but associated with various ‘psychedelic effects’ and often discussed among the classical psychedelics) has shown promise for treating Post-Traumatic Stress Disorder. Psychedelics and MDMA are incredibly safe compared to other substances (See figure 4).
For information about psychedelic assisted therapies, please see our page on this site.
- Global Burden of Disease Collaborative Network. Global Burden of Disease Study 2016
- Depression and Other Common Mental Disorders: Global Health Estimates. Geneva: World Health Organization; 2017. Licence: CC BY-NC-SA 3.0 IGO.
- Whitaker, R. (2010). Anatomy of an Epidemic: Magic Bullets. Psychiatric Drugs, and the Astonishing Rise of Mental Illness in America New York: Crown Publishers.
- Vos, T., Barber, R. M., Bell, B., Bertozzi-Villa, A., Biryukov, S., Bolliger, I., … & Duan, L. (2015). Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. The Lancet, 386(9995), 743-800.
- Vigo, D., Thornicroft, G., & Atun, R. (2016). Estimating the true global burden of mental illness. The Lancet Psychiatry, 3(2), 171-178.
- Australian Bureau of Statistics 2018, National Health Survey First Results, cat. no. 4364.0.55.001, ABS, Canberra.
- A likely underestimation due to it being reported over 10 years ago.
- Australian Bureau of Statistics. (2009). National Survey of Mental Health and Wellbeing: Summary of Results, 4326.0, 2007. ABS: Canberra.
- Australian Bureau of Statistics 2007, National Survey of Mental Health and Wellbeing: Summary of Results, cat. no. 4326.0, ABS, Canberra.
- AIHW (Australian Institute of Health and Welfare) 2011. Young Australians: their health and wellbeing 2011. Cat. no. PHE 140 Canberra: AIHW
- AIHW (Australian Institute of Health and Welfare) 2016. Australian Burden of Disease Study: impact and causes of illness and death in Australia 2011. Australian Burden of Disease Study series no. 3. Cat. No. BOD 4. Canberra: AIHW.
- The Australian Senate. (2010). The Hidden Toll: Suicide in Australia Report of the Senate Community Affairs References Committee. Commonwealth of Australia, Canberra.
- Australian Bureau of Statistics 2017, Causes of Death, Australia, cat. no. 3303.0, ABS, Canberra.
- Medibank Private Limited and Nous Group. (2013). The Case for Mental Health Reform in Australia: A Review of Expenditure and System Design.
- Whiteford HA, Buckingham WJ, Harris MG, Burgess PM, Pirkis JE, Barendregt JJ and Hall WD 2014. Estimating treatment rates for mental disorders in Australia. Australian Health Review 38(1):80–5
- APA. (2000). Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Revised (DSM-IV-TR). Washington, DC: American Psychiatric Publishing.
- Belsher, G., & Costello, C. G. (1988). Relapse after recovery from unipolar depression: a critical review. Psychological bulletin, 104(1), 84.
- Hollon, S. D., Thase, M. E., & Markowitz, J. C. (2002). Treatment and prevention of depression. Psychological Science in the Public Interest, 3(2), 39-77.
- Judd, L. L. (1997). The clinical course of unipolar major depressive disorders. Archives of General Psychiatry, 54(11), 989.
- Mueller, T. I., Leon, A. C., Keller, M. B., Solomon, D. A., Endicott, J., Coryell, W., . . . Maser, J. D. (1999). Recurrence after recovery from major depressive disorder during 15 years of observational follow-up. American Journal of Psychiatry, 156(7), 1000-1006.


Company Overview of PRETTL Electric Corporation
PRETTL Electric Corporation manufactures and markets wiring harnesses for the automotive industry in South Carolina. The company was founded in 1988 and is based in Greenville, South Carolina. PRETTL Electric Corporation operates as a subsidiary of Prettl International, Inc.
1721 White Horse Road
Greenville, SC 29605
Founded in 1988
Key Executives for PRETTL Electric Corporation
PRETTL Electric Corporation does not have any Key Executives recorded.
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