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Objectives: The objective of the present paper is to review the main results of recent European cycle databases on ovulation detection and determination of the fertile window performed by the women themselves.
Methods: The ongoing German Long-term Cycle Database currently comprises 32788 prospectively collected cycle charts of 1551 women, the I European Cycle Database (10 countries) 1328 women/19048 cycles, the II European Cycle Database (six countries) 782 women/6724 cycles, and the World Health Organization Database (one European country) 234 women/2808 cycles. The women record cycle parameters (cervical mucus changes, temperature rise, etc.), family planning intention and sexual behavior.
Results: With the symptothermal method of natural family planning it has become possible to determine the fertile window in order to avoid pregnancy with a method effectiveness of 0.3%. According to a small sub-study, the ovulation time observed by the women themselves correlates closely with ovulation detected by ultrasound and measurement of luteinizing hormone (correlation within 1 day in 89% of the 62 cycles). Fertility awareness methods can be integrated into the management of sub-fertility. They seem to shorten the time to pregnancy.
Conclusions: Self-observation of the fertile window puts women into a position to develop a high level of reproductive competence that could be used much more in different areas than is currently the case.


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Hutchinson council selects three city manager finalists. They will interview Nov. 22.
Three finalists for the Hutchinson city manager position were selected Tuesday night during a 2 ½ hour executive session of the city council.
The plan, said Mayor Jade Piros de Carvalho, is to try to interview all three on Nov. 22 and select a new manager by December, who will likely start in January or February.
The council voted on May 3 not to renew the contract for former manager Jeff Cantrell. Former Reno County administrator Gary Meagher has served as interim manager since and will continue to fill that role until a new manager is hired.
Assisted by the consulting firm Baker Tilly Virchow Krause LLP, the job posting drew some 45 applications from around the country. That company whittled that down to 11 for the city council to consider.
“We started the meeting with everyone identifying their top three or four candidates,” Piros de Carvalho said. “Everyone had different opinions about who the top ones should be, but after talking it through and rereading resumes and questionnaires and looking at their video interviews, we came to a pretty solid consensus who the top three should be.”
Three city manager finalists will tour Hutchinson, interview on Nov. 22
On the 22nd, the candidates will be given local tours and participate in separate interviews with a panel of city department heads, a small community panel, and the council.
“The goal is to do all three the same day,” Piros de Carvalho said, with different interviews possibly occurring simultaneously.
“All three of them are seasoned local government professionals,” she said. “They had a lot of experience in full service to a community like ours. We had a lot of applicants from smaller communities with not as many departments, but we really wanted to choose applicants with experience in a larger organization. Not as large as ours, but with the same complexity to them. We have a zoo, and we have an airport.”
“The three we chose to interview are those with solid experience with complex local government, and also ones we feel will fit the culture of Hutchinson and our organization,” she said. “We desire to choose someone who's really committed to collaboration and engagement in the community. A key consideration in our selection was if they demonstrated that in their former roles.”
The total pool of applicants was geographically dispersed, but a lot were from the Midwest, including “quite a few from Kansas," the mayor said.

domain: news


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|courtesy of mingpao.com|
|Ediward Chui (second left) and Wen Chao (right) easily pick up Hana Tam (left) and Nicole Tung (second right)|
|Nicole Tung (Tai Po Lulu)|
courtesy of on.cc
The Eric Tsang Chi Wai starred Lunar New Year film LUCKY STAR 2015 (GUT SING GO JIU 2015)'s actors including Wen Chao, Nicole Tung Ka Yi (Tai Po Lulu), Edward Chui Woei Dong and Hana Tam Hung Nam yesterday promoted the film in Causeway Bay. Tsui Siu Keung' son Chui Woei Dong said that two years ago he and Tai Po Lulu worked together on a commercial. He said that Tai Po Lulu at the time played a beautiful special agent. Working together again this time, he said, "I don't know how to be funny normally. When the director asked for me, I thought he was going to ask me to perform kung fu. I didn't expect him to want me to make faces and be funny, which I feel is a new challenge. I look like a replica of Papa, I hope he (the director) would see how I made fun of him (Papa) and showed the other side of cool for him." Playing in her first comedy, Tai Po Lulu said that in the film she and Taiwan group S.H.E.'s Ella had many scenes. Lulu said, "Ella often told jokes on the set, I learned a lot of expression changes from acting with her."

domain: artistic


Xiaomi Mi5c now official
After more than two years in the making, Xiaomi's first processor is finally official. Even more, it arrives inside a new smartphone. Dubbed Mi5c, this Surge S1-powered Android handset is a more affordable Mi5 variant with slightly lower specs as well.
In addition to the Xiaomi Surge S1 (according to the company's benchmarks, this chip is faster than the MediaTek Helio P10 and the Qualcomm Snapdragon 625, but slower than the MediaTek Helio P20), this new handset features 3 GB RAM, 64 GB internal storage, a 12 MP main camera, and a fingerprint reader placed on the front, inside the Home button.
Some details are still missing, but the price of the Mi5c is already public - around $220 USD. Sadly, this price tag only applies to the Chinese market. Other areas will have to wait for the Mi5c to arrive, but that might never happen. In the end, the Mi5c might be a local handset used to test the Surge S1 before using it in the upcoming Mi6.


text: At Talayna's they strive to make every order the best it can be. They use only quality ingredients to assure a quality product. Their St. Louis pizza is so light and crispy it's like eating pizza on a pastry shell. The New York is their hand tossed pizza, full of flavor, with all mozzarella cheese. The Chicago has a cornmeal crust with all mozzarella cheese and chunky sauce on top, a true pizza pie. All of their pastas are made to order for you with homemade sauce and come with salad. Their house salad dressing is delicious, it's a parmesan italian and a little sweet, you will love it.Give them a try, you won't be sorry. We are located in the old Busy Bee building.

domain: food


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In his recent letter, Dr. presence of plasma EO per se has remained controversial . New analytical studies and related findings are very relevant in this regard. For example, the use of high-performance liquid chromatography, coupled with offline multistage MS (MS2, and MS3), to examine the effects of pregnancy and of central angiotensin (Ang) II infusion on EO in rat plasma, led to the detection of EO and two other novel Chitosamine hydrochloride EO isomers [7,8]. These isomers have distinct chromatographic polarity compared to EO, while both have major MS2 and MS3 product ion spectra that are essentially indistinguishable from those of EO. Furthermore, both isomers bind to the anti-Ouabain antibody routinely employed in our radioimmunoassay (RIA), Chitosamine hydrochloride although affinity for the second isomer is at least an order of magnitude weaker that for EO. Both of these new isomers appear to be regulated independently from EO Chitosamine hydrochloride and may vary according to gender, age, and disease. Importantly, neither isomer was previously described nor is usually detectable in commercial sources of (herb) ouabain. Finally, recent work has confirmed that Chitosamine hydrochloride adrenal gland rat cells were able to produce and secrete EO compound . The presence of EO in human plasma remains controversial, fuelled in part by Baecher et al. , who were unable to detect EO in human plasma using LC-MS. It is worth noting that the primary conclusion, as well as other circumstances surrounding the claim of Baecher et al., have been questioned [11,12]. Moreover, the plasma extracts used by Baecher and colleagues tested positive for EO with a well-documented Radiommunoassay (RIA) run in our laboratory [13,14]. These RIA data are significant because, in prior studies, EO continues to be consistently discovered once the same test ingredients had been put through LC-MS and LC-RIA [15,16]. Furthermore, the important analysis of the task performed on EO contains evidence from indie laboratories in a number of continents collected from 1990 to 2009, that is in keeping with an endogenous way to obtain endogenous ouabain  within the circulation. Beginning with 2009 [17,18,19], steroid biosynthesis, hereditary polymorphisms, and renal function have already been associated with EO in a number of clinical settings, especially with regard towards the previously proven genes involved with EO synthesis: the (LSS) gene polymorphism on the rs2254524 AA vs. CC . LSS rs2254524 AA polymorphism was connected with: (1) a rise in the creation of EO after transfection in individual adrenal cells; (2) a rise of EO in renal tissues; and (3) a quicker loss of GFR regardless of similar degrees of blood circulation pressure . These results are consistent with both (4) an increase in the incidence of Acute kidney Injury (AKI) after cardiac surgery  in patients transporting LSS rs2254524 AA polymorphism; and (5) podocyte damages after incubation with ouabain in animal models . The latter evidence is prevented by the selective ouabain inhibitor, Rostafuroxin . Finally, (6) in na?ve hypertensive patients Rostafuroxin normalizes Blood Pressure (BP) in LSS AA carriers, but it is usually inactive in CC carriers . This is consistent with (7) specific data  showing the pressor effects of ouabain  in rats associated with the peculiar damage , and with (8) the presence of cell functional changes that are all prevented by Rostafuroxin . These 8 groups of impartial findings gathered from rats and humans, both at the genetic cell and whole-body level, certainly ITGB2 substantiate the above data on EO plasma levels and are also relevant for establishing the scientific truth. Further evidence adding to the relationship between circulating EO and certain genetic polymorphisms (and highlighting this system as a target in the era of precision medicine) is usually under development . In contrast to the in vivo cardio-protective effects of exogenous ouabain in rats, in our peer examined clinical studies we repeatedly observed that higher levels of circulating EO are associated with worsening outcomes among patients with cardiac and renal dysfunction. We should agree.
Irritation has an integral function within the pathogenesis of a genuine amount of psychiatric and neurological disorders. research using postmortem human brain samples showed the fact that deposition of proteins aggregates of -synuclein, termed Lewy systems, is certainly noticeable in multiple human brain regions of sufferers from PD and dementia with Lewy systems (DLB). Furthermore, the expression from the sEH proteins within the striatum from sufferers with DLB was considerably higher compared with controls. Interestingly, there was a positive correlation between sEH expression and the ratio of phosphorylated -synuclein to -synuclein in the striatum. In the review, the author discusses the role of sEH in the metabolism of PUFAs in inflammation-related psychiatric and neurological disorders. gene codes for the sEH protein is usually widely expressed HUP2 in a number of tissues, including the liver, lungs, kidney, heart, brain, adrenals, spleen, intestines, urinary bladder, placenta, skin, mammary gland, testis, leukocytes, vascular endothelium, and easy muscle. Interestingly, the sEH protein is usually most highly expressed in the liver and kidney (Gill and Hammock, 1980; Newman et al., 2005; Imig, 2012). Accumulating evidence suggests that EETs, EDPs and some other EpFAs have potent anti-inflammatory Gypenoside XVII properties (Wagner et al., 2014, 2017; Lpez-Vicario et al., 2015) which are implicated in the pathogenesis of a number of psychiatric and neurological disorders (Denis et al., 2015; Hashimoto, 2015, 2016, 2018; Gumusoglu and Stevens, 2018; Polokowski et al., 2018). Inflammation in Depressive disorder and sEH Depressive disorder, one of the most common disorders in the global world, is normally a significant psychiatric disorder with a higher price of Gypenoside XVII relapse. THE PLANET Health Company (WHO) quotes that a lot more than 320 million people of all age range have problems with unhappiness (World Health Company [WHO], 2017). Multiple lines of proof demonstrate inflammatory procedures within the pathophysiology of unhappiness and in the antidepressant activities of the specific substances (Dantzer et al., 2008; Miller et al., 2009, 2017; Raison et al., 2010; Hashimoto, 2015, 2016, 2018; Savitz and Mechawar, 2016; Raison and Miller, 2016; Zhang et al., 2016a,b, 2017b,a). Meta-analysis demonstrated higher degrees of pro-inflammatory cytokines within the bloodstream of drug-free or medicated despondent sufferers compared to healthful handles (Dowlati et al., 2010; Youthful et al., 2014; Haapakoski et al., 2015; Eyre et al., 2016; K?hler et al., 2018). Collectively, chances are that inflammation has a key function within the pathophysiology of unhappiness. Several reviews using meta-analysis showed that -3 PUFAs could decrease depressive symptoms Gypenoside XVII beyond placebo (Lin et al., 2010, 2017; Sublette et al., 2011; Mello et al., 2014; Grosso et al., 2016; Hallahan et al., 2016; Mocking et al., 2016; Sarris et al., 2016; Bai et al., 2018; Hsu et al., 2018). Eating intake of -3 PUFAs may be connected with lower threat of unhappiness. Significantly, EPA-rich -3 PUFAs could possibly be Gypenoside XVII recommended for the treating unhappiness (Sublette et al., 2011; Mocking et al., 2016; Sarris et al., 2016). Significantly, brain EPA amounts are 250-300-flip less than DHA in comparison to about 4- (plasma), 5- (erythrocyte), 14- (liver organ), and 86-flip (center) lower degrees of EPA versus DHA (Chen and Bazinet, 2015; Dyall, 2015). Provided the function of irritation in unhappiness, chances are that sEH might donate to the pathophysiology of unhappiness. A single shot of lipopolysaccharide (LPS) may create depression-like phenotypes in rodents after sickness behaviors (Dantzer et al., 2008; Zhang et al., 2014, 2016a, 2017b; Ma et al., 2017; Yang et al., 2017). Ren et al. (2016) reported the sEH inhibitor TPPU [1-(1-propionylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea] (Number 2).
Background: Esophageal cancer (EC) is one of the common cancers in China with high incidence and poor prognosis. of miR-143. Low miR-143 manifestation or high LASP1 manifestation connected with ESCC individuals decreased success significantly. miR-143 imitate transfection inhibited ESCC cell proliferation, invasion and migration in vitro, that was impaired by LASP1 overexpression. Summary: miR-143 suppressed cell proliferation, migration, and invasion by down-regulating LASP1. worth /th th colspan=”2″ align=”middle” rowspan=”1″ hr / /th th align=”middle” rowspan=”1″ colspan=”1″ Low (n = 26) /th th align=”middle” rowspan=”1″ colspan=”1″ Large (n = 18) /th /thead em Age group (years) /em P = 0.803???? em 50 /em 19118 em ???? 50 /em 251510 em Gender /em P = 0.854 em ????Guy /em 301812???? em Female /em 1486 em TNM stage /em P = 0.000a em ????II /em 19613 em ????III /em 17125 em ????IV /em 880 em Tumor size /em P = 0.546 em ???? 5 cm /em PSI-7977 231211 em ???? 5 cm /em 21147 em Vessel invasion /em P = 0.023b em ????Adverse /em 341618 em ????Positive /em 10100 Open up in another window a em p /em -value 0.001; bP 0.01. Up-regulation of miR-143 inhibited cell proliferation, migration, and invasion in ESCC To help expand verify the function of miR-143 in ESCC, we examined the manifestation of the miRNA in a number of ESCC cell lines along with a nonmalignant, immortalized esophageal epithelial cell range SHEE by qRT-PCR. As demonstrated in Shape 2A, miR-143 expression was reduced ESCC cell lines in comparison to SHEE cells significantly. By transfecting miR-143 imitate into Eca109 and KYSE510 cells, miR-143 level in both cell lines was considerably increased in comparison to those transfected with miRNA imitate control (miR-NC imitate) (Shape 2B). As exposed by MTT assay outcomes, upsurge in miR-143 level considerably inhibited cell development in both ESCC cell PSI-7977 lines (Shape 2C and ?and2D),2D), as the transwell assay outcomes showed that cell migration and invasion capability of both ESCC cell lines was significantly reduced by miR-143 upregulation (Shape 2E and ?and2F).2F). These total results suggested that up-regulation of miR-143 could attenuate the malignancy of ESCC cells in vitro. Open in another window Shape 2 Upregulation of miR-143 inhibited cell proliferation, migration, and invasion in ESCC cells. (A) The miR-143 manifestation level in SHEE and four esophageal tumor cell lines; GAPDH was utilized as an interior control (B) The manifestation of miR-143 was improved in KYSE510, Eca109 cells transfected with miR-143 mimics. (C, D) MTT assay was used to judge the result of miR-143 mimic transfection on KYSE510 and Eca109 cells proliferation. (E) Transwell migration assay was utilized to evaluate the effect of miR-143 mimic transfection on Eca109 and KYSE510 cells migratory capacity. (F) Transwell invasion assay was used to evaluate the effect of miR-143 mimic transfection on Eca109 and KYSE510 cells invasive capacity. ***P 0.001. LASP1 was a target of miR-143 To explore the mechanism of action of miR-143 in ESCC, we performed bioinformatic analysis and identified LASP1 mRNA as a potential target of miR-143 (Figure 3A), To confirm this predicted result, a luciferase reporter vector containing the full-length LASP1 mRNA 3 UTR (LASP1-WT) and a luciferase reporter vector containing the mutated LASP1 mRNA 3 UTR (LASP1-MUT) was constructed and transfected into HEK293T cells. Co-transfection with miR-143 mimics or miR-143 PSI-7977 inhibitor significantly decreased or increased luciferase activity in HEK293T cells transfected with LASP1-WT reporter plasmids but not in those with LASP1-MUT ones (Figure 3B and ?and3C).3C). These results suggested that 3 UTR of LASP1 mRNA is a direct target of miR-143. Open in a separate window Figure 3 LASP1 is a target of miR-143. A. Binding and mutant sites between LASP1 and miR-143. B. Luciferase activity was detected in HEK 293T cells after co-transfection with miR-143 mimics or miR-NC mimics and LASP1-WT or LASP1-MUT reported plasmid. C. PSI-7977 Luciferase activity was detected in HEK 293T cells after co-transfection with miR-143 inhibitors/miR-NC inhibitors and LASP1-WT or LASP1-MUT reporter plasmid. ***P 0.001. miR-143 directly regulated LASP1 expression in ESCC Previous studies have demonstrated that LASP1 can promote ESCC cell proliferation, migration and invasion in vitro, but the clinical significance of this genes expression was not evaluated. We therefore measured the expression of LASP1 PSI-7977 in ESCC and adjacent tissue specimens by qRT-PCR, and analyzed the influence Rabbit Polyclonal to COX41 of LASP1 expression on ESCC patients overall survival. The results showed that LASP1 expression was significantly higher in ESCC tissues compared to non-malignant counterparts (Figure 4A), and survival of ESCC patients with high LASP1 expression was significantly lower compared to those with low LASP1 expression (Figure 4B). We also found that LASP1 expression was significantly increased in YSE510 and Eca109 cells compared to SHEE cells (Figure 4C). Pearsons correlation analysis revealed that.
Supplementary MaterialsTable_1. acids were measured using gas chromatography. Results: We found that opportunistic pathogens (e.g., Enterobacteriaceae and Veillonellaceae) and lactate-producing bacteria (e.g., and 0.05). However, white blood cell, neutrophils, and reddish blood cell counts and high level of sensitivity C-reactive protein were significantly higher in the HR group than in the LR group. High-density lipoprotein cholesterol was least expensive in the HR group. Diet habit can affect the risk of stroke. In this study, 48 participants were vegetarian, 84 EHT 1864 were omnivorous, and only 9 were carnivorous. There was no significant difference in dietary pattern among the three organizations (Table 1, Pearson chi-square test, = 0.648). Table 1 Characteristics of the study participants. = 51)= 54)= 36)= 0.06), Shannon index (KruskalCWallis test, = 0.25), Chao 1 index (KruskalCWallis check, = 0.21), and Observed types (KruskalCWallis check, = 0.07) were used to judge the alpha variety of each test. Our analysis uncovered no significant distinctions in alpha diversity index among the three organizations, but a slight decrease was observed in the HR group (Numbers EHT 1864 4ACD). Open in a separate window Number 4 Microbial diversity and the average large quantity of opportunistic pathogens among the LR (= 51, green), MR (= 54, blue), and HR organizations (= 36, reddish). (ACD) Alpha diversity among the three organizations. (ECJ) The relative abundances of opportunistic pathogens in the gut among the three organizations. The significances ( 0.05 when a comparison was performed with the LR group. LR, low-risk group; MR, medium-risk group; HR, high-risk group. PD, phylogenetic diversity. To determine Rabbit polyclonal to Neuropilin 1 the variations in microbial structure among the three organizations, we performed beta diversity analysis using PCoA (an approach based on BrayCCurtis range) within R software. Further screening was performed via Adonis. We found risk organizations to be significant sources of variability in terms of gut microbiota (Adonis test, = 0.03). Furthermore, a linear tendency in the BrayCCurtis range was observed from your LR group to the HR group (Number 2A). In the pairwise assessment of BrayCCurtis range, the LR and HR group were obviously disparate (Adonis test, = 0.005), but variations between the LR and MR groups were less significant (Adonis test, = 0.085). Open in a separate window Number 2 Variations in the composition of gut microbial areas between the LR (= 51, green), MR (= 54, blue), and HR (= 36, reddish) organizations. (A) Beta diversity assessment among the three organizations. Principal coordinates analysis (PCoA) based on BrayCCurtis range was used to illustrate the variations between the three organizations. Average relative large quantity of dominating microbes among the LR, MR, and HR organizations at the family level (B) and phylum level (E), with each color representing a taxon. (C) Significantly discriminative taxa among the LR, MR, and HR organizations were identified using linear discriminant analysis effect size (LEfSe) analysis. (D) Cladograms based on LEfSe results of the LR EHT 1864 and HR organizations. LR, low-risk group; MR, medium-risk group; HR, high-risk group. The fecal bacterias community discovered in all groupings was dominated by 127 genera owned by 5 main phyla (Amount 2E), including Firmicutes, Bacteroidetes, Proteobacteria, Verrucomicrobia, and Fusobacteria. One of the most predominant 15 households that constructed 92.5% of the full total bacteria abundance were Bacteroidaceae, Ruminococcaceae, Lachnospiraceae, Enterobacteriaceae, Prevotellaceae, Veillonellaceae, Porphyromonadaceae, Alcaligenaceae, Fusobacteriaceae, Verrucomicrobiaceae, Rikenellaceae, Clostridiaceae, S24-7, Desulfovibrionaceae, and Streptococcaceae (Amount 2B). Although these bacterias talked about could possibly be discovered in the gut of every subject matter above, the relative plethora from the same microorganism in the intestines of different individuals was different. For example, the average great quantity of phylum Proteobacteria was 12.41%, which range from 2.16 to 53.52%. The common abundance of family members Enterobacteriaceae was 7.74%, but range between 0.26 to 50.39%. The comparative abundance from the dominating taxa in the phylum (Shape S3) and family members levels (Shape S4) was illustrated in the region charts. To recognize abundant microbiota among the three organizations EHT 1864 differentially, linear discriminant evaluation (LDA) in conjunction with impact size dimension (LEfSe) was performed. With this process, we established that Enterobacteriaceae was enriched in the HR group, while those of the Erysipelotrichaceae subclass, the Ruminococcaceae family members, as well as the genera had been mostly linked to low threat of heart stroke (Shape 2C). LEfSe further exposed significant distinctions in bacterial taxa between your LR and HR organizations: as well as the aforementioned taxa, we noticed that the comparative great quantity of Proteobacteria, Bacilli, Lactobacillales, Veillonellaceae, Streptococcaceae, in the HR group was also greater than that in the LR group (Shape 2D). AN INCREASED Great quantity of Opportunistic Decrease and Pathogens Great quantity.
Deposition of tophus is a common feature in chronic gout pain; however, signs and symptoms are not usually well-pronounced in cases of uncommon sites. finger since 1 month ago. He also noticed a slowly enlarging mass over the volar aspect of his right distal forearm within the past year. Ever since then, patient also felt numbness at his thumb, index, and long finger, which worsened when his long finger was extended. His long finger was held fixed in the flexed position in an attempt to relieve the pain and numbness sensation. There was no history of fever, night sweats, weight loss, decrease in appetite, malaise, or fatigue. There was no history of trauma or pain at other joints of the body or morning stiffness. Patient was not exposed to any vibratory tools. Patient has a history of hyperuricemia since 10 years ago and was not treated regularly. On physical examination, paresthesia was found along the distribution of median nerve with decreased grip strength and flattening of the thenar eminence. Tinel sign was positive. At the forearm region, a solid mass of approximately 3 cm x 2 cm was palpated at the volar aspect proximal to the flexor retinaculum. It was non-tender, noncompressible, and cellular without regional upsurge in pores and skin or temperatures adjustments. Movement of wrist was regular with limitation of lengthy finger extension. Lab findings revealed raised serum the crystals (9.2 mg/dL) and reduced estimated glomerular filtration price (eGFR, 70 mL/min/1.73 m2; mildly reduced renal function based on the Chronic Kidney Disease Epidemiology Cooperation computation). Radiological results demonstrated no significant adjustments. MRI uncovered a fusiform mass, that was heterogeneous isointense on sagittal T1-picture and heterogeneous hyperintense on axial fats suppression picture inside the flexor digitorum superficialis (FDS). We opted to execute surgical exploration to eliminate the mass utilizing a longitudinal incision along the wrist flexion crease increasing proximally. Superficial dissection uncovered a white chalky mass, which acquired infiltrated the FDS tendon. Median nerve was compressed with the tophus. The mass didn’t to the encompassing structures adhere. Excision from the nodular tophus was performed yet not because of extensive intratendinous infiltration thoroughly. We performed carpal tunnel decompression also. Individual was presented with allopurinol after that. A month after medical procedures, the wound healed with significant improvement of symptoms and elevated flexibility of the lengthy finger. There is no recurrence or brand-new lesion somewhere else (Body 1). Open up in another window Body 1 Clinical picture of correct hand using AIbZIP the lengthy finger set in the flexion placement and flattening from the thenar eminence. Records: Excised mass is certainly shown. MRI exposing heterogeneous fusiform mass within flexor digitorum superficialis. Case 2 A 44-12 months old male presented with a visible mass over the dorsal aspect of his right dominant hand. The mass was enlarging gradually for the past 3 months and was painless. No mass was found elsewhere. The patient sought treatment due to his failure to fully flex his right long finger. There was Flavopiridol HCl no significant previous history of trauma or comparable condition found in Flavopiridol HCl the family. On physical examination, we found a visible mass over the dorsal aspect of right hand (over the third metacarpal), which was visibly moving as the long finger was flexed and extended. There was limited flexion as the mass reached the metacarpophalangeal joint region. There were Flavopiridol HCl no skin color changes or local change in skin heat. The mass itself was felt solid-hard with irregular surface and obvious border, sized 4 cm 3 cm and fixed to the extensor digitorum tendon Flavopiridol HCl of the long finger. There was no tenderness. Laboratory results were insignificant except for the serum uric acid (8.4 mg/dL) and decreased eGFR (81 mL/min/1.73 m2; mildly decreased renal.
Identifying the sets of transcription points (TFs) that control each human gene is certainly a intimidating task that will require integrating numerous experimental and computational approaches. which allows screening in a 1,536 colony structure. This allows for the dramatic upsurge in throughput (60 DNA-bait sequences against 1,000 TFs will take fourteen days per researcher) and reproducibility. We illustrate the various types of anticipated results by examining human being promoter sequences against an array of 1,086 human being TFs, as well as examples of issues that can arise during screens and how to troubleshoot them. promoters, enhancers, silencers, etc.) and a TF-prey, which can be screened for reporter gene activation9,10 (Number 1B). The DNA-bait is definitely cloned upstream of two reporter genes (and DNA-centered TF-DNA relationships networks to-date. In particular, we have recognized 2,230 relationships between 246 human being developmental enhancers and 283 TFs12. Further, we have used eY1H assays to uncover modified TF binding to 109 solitary nucleotide noncoding variants associated with genetic diseases such as developmental malformation, malignancy, and neurological disorders. More recently, we used eY1H to delineate a network comprising 21,714 relationships between 2,576 gene promoters and 366 TFs11. This network was instrumental to uncover the functional part of dozens of TFs. The protocols to generate DNA-bait staining and MPEP HCl evaluate the levels of background reporter activity have been reported elsewhere15C17. Here, we describe an eY1H pipeline that can be used to display any human being genomic DNA region against an array of 1,086 human being TFs. Once a candida DNA-bait strain is definitely generated and a TF-prey array is definitely noticed onto the related plates, the entire protocol can MPEP HCl be performed in two weeks (Table 1). More importantly, the protocol can be parallelized so that a single researcher can display 60 DNA-bait sequences MPEP HCl simultaneously. To demonstrate the protocol we screened the promoters of two cytokine genes CCL15 and IL17F. In addition, we show results from failed screens HOXA11 to illustrate the types of problems that may arise when carrying out eY1H assays and how to troubleshoot them. Table 1: Timeline for eY1H display knockout animals11. This is a similar validation rate to that observed for ChIP-seq data21. Although, relationships recognized by eY1H are highly reproducible when retesting the same candida DNA-bait strain, screening different candida strains for the same DNA-bait create different sometimes, although overlapping, pieces of TF-DNA connections. This is because of differences in background reporter activity between strains usually. In addition, examining fragments of the DNA sequence bring about the recognition of even more TF-DNA connections than testing the entire sequence, specifically when overlapping fragments are examined. This can be related to the assay getting better in identifying connections that are near to the reporter minimal promoters, and because assessment overlapping fragments reduces the probabilities a binding site may be occluded by fungus nucleosomes. Thus, for little scale projects, it is strongly recommended that overlapping 0.5C1 kb fragments of the regulatory region are tested which two unbiased strains are screened for every DNA-bait series8. There are many critical steps in the eY1H screening protocol in order to avoid a number of the presssing issues presented in Figure 3. Initial, although most mass media substances are stable for many months (aside from 3AT and X-gal) too little proper colony development likely signifies that at least among the substances may have dropped activity and really should end up being replaced. Second, it’s important to get ready the rectangular plates so the agar is normally leveled therefore that they don’t dry for several day in order to avoid failing in pinning with all the robotic system. Finally, it really is essential to utilize the robotic system applications as indicated in the process (revisit, recycle, blending, etc.) for the fungus to successfully end up being moved, for mating to become efficient, also to prevent cross contaminants between fungus clones. The illustrations we selected to illustrate the use of eY1H screens correspond to human being gene promoters. However, additional regulatory areas can also be tested including enhancers and silencers. For example, we have used eY1H assays to evaluate TF binding to human being developmental enhancers and to 1st introns12,22. In addition, given that relationships are tested inside a pairwise manner, eY1H assays can be used to compare relationships between non-coding variants, and between TF coding sequence variants. For example, using eY1H assays we recognized modified TF binding to 109 noncoding variants associated with different genetic diseases, and also differential relationships profiles for 58 TF missense mutations12,14. Although, this protocol focuses on evaluating TF binding to human being regulatory regions, DNA areas from various other types could be also.
Supplementary MaterialsTable_1. bottles containing (1) moist cellulosic materials, (2) moist cellulosic materials with compost Machine, and (3) moist cellulosic materials with compost Accelerator. Outcomes showed that compost accelerated the pressure build-up in the storage containers which methane gas was stated in one test out compost and one test without compost as the pH continued to be natural throughout the 464 times experiment. Methane had not been produced in the various other experiment as the pH became acidic. After the pressure became very similar in all storage containers after 464 times, we then supervised gas pressure and structure in glass container containing moist cellulosic materials in (1) acidic circumstances, (2) natural circumstances, and (3) with an enzyme that RBBP3 accelerated degradation of cellulose over 1965 times. In these tests, acetogenic bacterias degraded created and cellulose acetic acidity, which acidity suppressed methane creation. Microbial community analyses recommended a different community of archaea, BI-78D3 bacterias and fungi degrading cellulose actively. DNA analyses confirmed the current presence of methanogens and acetogens inside our tests also. This scholarly study shows that methane gas will be generated in DGRs if pH remains neutral. However, our outcomes demonstrated that microbial degradation of cellulose not merely generated gas, but generated acidity also. This selecting is normally essential as acids can limit bentonite bloating and possibly degrade rock and roll and concrete obstacles, this involves consideration in the safety case as appropriate thus. (lyophilized natural powder, 0.3C1.0 device/mg great, Sigma) at a beginning pH of 7 utilizing a natural phosphate buffer. Information on the starting circumstances for each test are detailed in Desk 2. These three fresh tests lasted for 1965 times. Table 2 Test names, beginning condition as well as the elapsed amount of time in times when the headspace gases had been sampled. gDNA at 0.1 ng/L was used across a temperature selection of 52 to 62C inside a 3-stage cycle. The perfect of 6.7 10-4 mole/mL/min (Coleman et al., 2007) like a reference. Examples having fluorescence ideals that exceeded the number of the typical curve were re-analyzed and diluted. Results Advancement of Gas Stresses and Composition The introduction of gas pressure inside each one of the check containers varied with regards to the timing of gas pressure starting point, the pace of gas pressure starting point and the price of gas pressure modification on the monitoring period. The pace of modification of pressure inside the un-amended check container displayed a short decrease in gas pressure that lasted 80 times, followed by hook increase beginning at about day time 130, which in turn leveled off at 115 kPa for another 120 times before showing another amount of raising pressure to 130 kPa at day time 464 (Shape 1). At that right BI-78D3 time, the gas structure was 26% skin tightening and, 62% nitrogen, 12% methane and 0.008% hydrogen (Figure 2). The pH in the leachate was 7 pH. Open in another window Shape 1 Advancement of gas pressure and headspace BI-78D3 gas compositions without adding compost (control) and after adding Compost Accelerator and Compost Manufacturer over 464 times (A). Amounts in gray match the vertical grey lines marking when the headspace gases had been sampled for evaluation at 464 times elapsed time. Advancement of gas pressure and headspace gas compositions after adding a citrate buffer (acidic), a phosphate buffer (natural), and cellulase over 1965 times (B). Amounts in gray match the vertical grey lines marking when the headspace gases had been sampled for BI-78D3 evaluation at 150, 464, 730, and 1965 times elapsed time. Demonstrated will be the structure from the nitrogen Also, oxygen, argon, skin tightening and, hydrogen, and methane in the headspaces and in dried out air. Open in a separate window FIGURE 2 Community differences for cellulose and leachate by differential relative abundances of gene copies detected within the surrogate waste for: Archaeal rRNA (A16S), fungal rRNA (18s), and bacterial glutamine synthetase (glnA), genes. Addition of the compost additives, Compost Maker (with microorganisms within its composition) and Compost Accelerator (with enzymes within its composition), increased the rate of gas pressure onset (Figure 1). Compared to the cellulosic material without compost added, BI-78D3 the cellulosic material amended with the additive that included enzymes within its composition (Compost Accelerator, Figure 1) displayed the quickest onset of gas pressure and the fastest rate of gas pressure rise. These periods were preceded by an initial decline in the headspace gas pressure. By.
Supplementary Materialsijms-20-00860-s001. to a binding affinity multiple moments greater than that of some other reported Bcl-2 inhibitor. This protein-ligand discussion will not implicate alternations in proteins conformation, as recommended by SAXS. Additionally, bioinformatics techniques were used to recognize deleterious non-synonymous solitary nucleotide polymorphisms (nsSNPs) of Bcl-2 and their effect on venetoclax binding, recommending that venetoclax discussion is normally preferred against these deleterious nsSNPs. Apart from the BH3 binding groove of Bcl-2, the flexible loop domain (FLD) also plays an important role in regulating the apoptotic process. High-throughput virtual screening (HTVS) identified 5 putative FLD inhibitors from the Zinc database, showing nanomolar affinity toward the FLD of Bcl-2. Value= 28 nM) , the Tm of venetoclax is almost 4-fold. This observation corroborates the strong binding affinity reported by Souers et al. ( 0.01 nM). Concomitant with the increase in protein stability, the interaction between venetoclax and Bcl-2 might implicate conformational changes in the protein tertiary structure. Urea PAGE and SAXS measurements were performed to assess this hypothesis. The urea electrophoresis revealed a significant increase in electrophoretic mobility of Bcl-2 upon incubation with venetoclax. This Muscimol is in agreement with the strong binding reported for venetoclax and validated by the TSA, indicating that the protein assumes a more stable conformation upon venetoclax binding. However, since chemical denaturation is the methodology used, protein stability could be a Muscimol more relevant factor in electrophoretic mobility than protein conformation. The electrophoretic results may suggest, as well, that the ligand free chimeric Bcl-2 form has poor stability and thus resistance to denaturation, while the ligand-bound Bcl-2 is more stable and may display a larger mobility in the gel. To shed light on the hypothesis that Bcl-2 undergoes significant conformational alterations upon binding venetoclax, SAXS data was collected on ligand free and ligand-bound samples. The results indicate similar folding for both free and venetoclax-bound states. Considering the strong interaction between Bcl-2 and venetoclax reported and validated NKSF2 by the TSA and the Urea PAGE, it seems unlikely that the ligand would dissociate from Bcl-2 upon elution in the SEC. Therefore, although venetoclax binding to Bcl-2 appears to increase drastically protein stability, the protein folding remains native-like without detectable conformational changes. Since venetoclax was derived from the navitoclax (ABT-263) scaffold, it was expected to bind in the same Bcl-2 groove, establishing a few new interactions with other protein residues which dictate its selectivity when compared to Bcl-xL and Bcl-w. In agreement with the binding affinity reported by Souers et al. and the TSA and electrophoretic results here presented, highly favoured interactions of venetoclax toward chimeric and physiological Bcl-2 were predicted by molecular docking, of ?11.35 kcal/mol and ?10.24 kcal/mol, respectively. The docking calculations for the chimeric Bcl-2 suggest that venetoclax interacts with F112, T132 and E136 of Bcl-2, which do not belong to the binding network found for the Bcl-2:navitoclax complex (PDB code 4LVT). In fact, these residues are spatially close and appear to impact the venetoclax binding setting through hydrophobic relationships significantly, in comparison with navitoclax. In the entire case from the physiological Bcl-2 type, the docking computations display relationships with L95, R98, Q99, L201, G203 and P204, in comparison to the docking from the chimeric type. The lot of interaction sites suggests a good binding between physiological venetoclax and Bcl-2. The structural alignment of Bcl-2 with Bcl-xL (PDB  Identification: 2LPersonal computer ) and Bcl-w (PDB  Identification: 1MK3 ), (Numbers S5 and S6) through the framework comparison tool offered in the PDB Muscimol , demonstrated that T132 isn’t conserved in these Bcl-2 homologues, that leads towards the hypothesis that residue can be pivotal for the venetoclax specificity toward Bcl-2..
Supplementary MaterialsS1 Appendix: Excel spreadsheet containing uncooked data from the study. prevent secondary infections. Intro Myiasis, the parasitic infestation of live mammals by take flight larvae (maggots), is an extension of the carrion-feeding practices of blowflies . Gravid females of myiasis-inducing flies such as botfly (Oestridae) and blowfly (Calliphoridae) are captivated and stimulated to lay their eggs on open wounds and even natural body openings of living mammals body by a variety of cues, predominantly olfactory ones . On hatching of the eggs, the larvae invade the broken feed and pores and skin within the hosts living or deceased tissues and body liquids . Myiasis, is normally an internationally severe vet and medical issue. In humans, it really is a problem of neglected wounds [3; 4]. In hospitals Particularly, the nourishing actions of larvae may lead bedridden sufferers to build IACS-8968 R-enantiomer up cutaneous lesions quickly, additional oviposition, debilitation, and loss of life. Furthermore, blowflies can become providers of pathogenic bacterias [5; 6; 7]. The larvae of myiasis-inducing flies have an effect on both outrageous  and local mammals increasing both financial and pet welfare problems . In pet husbandry over the global globe, the most frequent infected host may be the local sheep, where cutaneous flystrike or myiasis, is mainly due to blowflies from the genus (Diptera Calliphoridae) . Flystrike is normally a problem for the sheep sector. It can bring about sheeps serious tissues injuries, lack of efficiency and reproductivity and in the pets loss of life  eventually. In wool-producing countries, flystrike kills an incredible number of minds of sheep a complete calendar year . In Australia, the annual costs of flystrike, including reduction and mortality of creation, have been approximated at up to 280 million A$ . IN THE UK, myiasis was proven to IACS-8968 R-enantiomer have an effect on 75% of farms , with around cost around 3 million GBP  a calendar year. Presently, the prophylaxis against flystrike depends on artificial insecticides, such as for example organophosphates and insect development regulators (benzoylphenyl ureas, cyromazine and dicyclanil) [16; 17; 12] and, specifically for Merino lambs in Australia’s comprehensive wool sector, on painful operative husbandry procedures like the docking as well as the mulesing [18; 19]. Nevertheless, the aspect ramifications of artificial insecticides, such as the development of insect resistance , the harmful effects on sheep , farmers , and the environment , as well as the rising concerns about animal welfare  have made alternate strategies a high priority. In recent years, essential oils (EOs) of aromatic vegetation species have captivated great attention as natural products that can efficiently act as insecticides and repellents against insect pests [25; 26; 27; 28; IACS-8968 R-enantiomer 29]. Moreover, since EOs usually have a low toxicity to mammals , and high biodegradability, they may be regarded as very promising substances for the formulation of low-toxic, eco-friendly pest control products .The common green bottle fly (Meigen) (Diptera Calliphoridae) (Fig 1) is a common blowfly frequently found in synanthropic and natural ecosystems in most areas of the world and, along with (Wied.), and (L.), it is a common cause of human being and animal cutaneous myiasis [32; 33]. H3F3A Open in a separate windowpane Fig 1 Adult of (Meigen) (Diptera Calliphoridae). (Kunth) Kuntze (Lamiaceae) is definitely a typical flower of the high mountains of Ecuador, with an overpowering smell, well known and mainly used by local people for its beneficial properties. Such varieties is definitely widely spread in the Andean region of South America, where it is known as tipo de cerro . It is.
Supplementary MaterialsTable_1. data in baseline and two years in both groupings following-up. Adjustments of UACR from baseline to follow-up weren’t affected in both groupings: ?1.61(?10.24, 7.17) mg/g in the TCM group and ?0.73(?7.47, 6.75) mg/g in the control group. For sufferers with UACR 30 mg/g at baseline, LWDH and Ginkgo biloba reduced the UACR worth in two years [46 significantly.21(34.96, 58.96) vs. 20.78(9.62, 38.85), 0.05]. Furthermore, the transformation of UACR from baseline to follow-up WST-8 in the TCM group was significant greater than that in the control group [?25.50(?42.30, ?9.56] vs. ?20.61(?36.79, 4.31), 0.05]. Bottom line: LWDH and Ginkgo biloba may attenuate deterioration of albuminuria in type 2 diabetes sufferers. These results claim that TCM is normally a promising choice of renoprotective realtors for early stage of DN. Trial enrollment: The analysis was signed up in the Chinese language Scientific Trial Registry. (no. ChiCTR-TRC-07000037, chictr.org) = 300) orally 3 x each day, or matching placebos (placebo group, = 300) WST-8 (Amount 1). Randomization was performed by an unbiased doctor in each medical center with block randomization method. Individuals, investigators, and the sponsor’s medical team were all blinded to treatment allocation. Subjects were adopted up with medical center consultation for 2 years. Open in a separate window Number 1 Circulation of participants in the trial. Main End Point The primary outcome variable was the switch in urinary albumin/creatinine percentage (UACR) before and after treatment. Within the 1st visit, each subject was fasted immediately (at least 8 h), and attended the medical center at 08:00. An over Rabbit Polyclonal to RCL1 WST-8 night first-void urine sample was collected from each patient to measure WST-8 the UACR. Normal albuminuria was defined as an UACR 30 mg/g. Individuals were considered to have microalbuminuria if their UACR ranged in 30C299 mg/g. Macro albuminuria was defined as UACR 300 mg/g. Additional Results All blood samples were immediately acquired at 08:00 after over night. Enzyme-linked immunosorbent assay was used to detect the high-sensitivity C-reactive protein (HS-CRP) (Lot 78034031, Bender Med Systems GmbH, Austria; minimum detection limit: 3 pg/ml; intra-assay CVs: 6.9%; inter-assay CVs: 13.1%), matrix metalloproteinase 2 (MMP2) (Lot 303216, R&D, USA; minimum detection limit: 0.047 ng/ml; intra-assay CVs: 5.6%; inter-assay CVs: 7.4%), soluble advanced glycation end products (sRAGE) (Lot 303510, R&D, USA; minimum detection limit: 4.12 pg/ml; intra-assay CVs: 5.7%; inter-assay CVs: 7.7%), and fractalkine (Lot 301156, R&D, USA; minimum detection limit: 0.018 ng/ml; intra-assay CVs: 2.6%; inter-assay CVs: 6.6%). The concentrations of serum AGE-peptides (AGE-P) were measured by circulation injection assay (FIA) (24). The subject was consumed a standardized breakfast (100 g steamed breads). Venous blood were sampled before and after breakfast, and fasting blood glucose (FBG), HbA1c, total cholesterol (TC), total triglyceride (TG), HDL, LDL, and postprandial blood glucose (PBG) were measured. The glomerular filtration rate (GFR) was estimated using the equation recommended from the National Kidney Basis in the Modified Diet in Renal Disease (25). Adverse Events Adverse events included cancer, stroke, coronary artery disease, bleeding, and many transient minor issues, such as dizziness, nausea, hypoglycemia, pores and skin itching or headache. Participants were count only for once. Statistical Analysis Paired sample 0.05 was considered to be statistically significant. All analyses were performed using SPSS software (version 17.0; SPSS Inc). Data were offered as means SD or Median (lower quartile, top quartile). Results Fundamental Characteristics Six hundred type 2 individuals were enrolled, 74 of which were lost during the follow-up, i.e., 34 individuals in the TCM group and 40 in the placebo group, and the reasons for these dropouts were reported in Number 1. There was no difference in age group, gender, length of time of known diabetes, BMI, blood sugar, HbA1c, SBP, DBP, HDL, LDL, TC, TG, GFR, or the current presence of microalbuminuria between your two groups on the baseline. Baseline scientific characteristics had been well-balanced between your two groups through the two years treatment (Desk 1). Desk 1 The characteristics at baseline and two years treatment of TCM and placebo. (%)151 (50.33)146 (48.67)Diabetes length of time (years)5.30 4.515.65 5.15GFR (mL/min/1.73m2)86.52 19.5788.21 19.98ACR 30 mg/g, (%)45 (17.31)32 (12.03)Family members former background of T2DM, (%)105 (35)109 (36.30)Background of retinopathy disease, (%)61 (20.33)68 (22.67)GLUCOSE-LOWERING THERAPIES, = 206) and TCM group (= 225) before and following treatment. The.

domain: literature


text:
Jane’s World stars the loveable misfit, Jane Wyatt. It’s a comic full of girl-on-girl action, chicks with guns, a vegan menace, vintage Winnebagos, drag queens, and downward career spirals. You know, the usual for stability-challenged Jane. In short, Jane is a magnet for the kind of drama that makes for good comedy. More comics by Paige Braddock can be found at pb9.com.
Pairing vintage comic art with hilarious, new dialog by Disney veteran writer John Lustig, Last Kiss revels in the absurdities of love, lust and 'life with lip.' The series originated when Lustig bought the publishing rights to a romance comic book series from the 50's and 60's, and started rewriting the stories for fun. Since then, the re-dialogued comics have been a popular feature in newspapers, magazines, comic books and greeting cards. Today Last Kiss is gaining popularity and is also available on email cards from Jib Jab and greeting cards from NobleWorks. Check www.lastkissinc.com for the latest news and product launches.
Ten abandoned cats live in an old warehouse where they are looked after by a young girl named Annie. They include Chesney, the ringleader, Jack, his sidekick, and Oliver - a wide-eyed kitten. The warehouse contains a boardroom on the very top floor, where, unbeknownst to Annie the moggies conduct the world's business through the eyes of a cat. In 2013, Ten Cats, created by Graham Harrop, won the prestigious Reuben Award in the Best Online Comics - Short Form division.
Follow Rob Harrell's hilarious and true-to-life work-at-home dad, Adam, as he chases deadlines, family bliss and the perfect latte.
Invisible Bread is a comic strip with comics about practically everything! Join the people in the Invisible Bread universe and see how normal, everyday situations can quickly transform into situations that are anything but normal.
Tom the Dancing Bug is a unique hybrid of editorial and comic strip cartooning, beloved by people because of its insightful and hilarious social and political satire. The strip appears weekly in newspapers around the country.
Tom the Dancing Bug
J.C. Duffy's hilarious strip features the four Fusco bachelors - Rolf, Lance, Al and Lars, along with Lance's girlfriend, Gloria, and Axel, the faithful wolverine. For off-the-wall antics and verbal acrobatics, you must go Fusco.
The Fusco Brothers
The Nutz family is definitely not the Cleavers, the Waltons or the Bradys. But you'll undoubtedly recognize them anyway. Most likely, they're a lot like the family you grew up in... where the battle for the last chicken leg is comparable to the Battle of Bull Run, sibling rivalry is putting it mildly, and family values usually refers to a coupon book. Soup to Nutz by Rick Stromoski stars hard-working Roy Nutz, his loving wife Pat, and their battling brood - sons Roy-boy and Andrew, daughter Babs and rambunctious dog Rosco. Stromoski is the seventh in a family of 12 children. Growing up in such a large family has given him an especially developed sense of humor that he has expressed through drawing from the moment he could pick up a pencil. A self-taught cartoonist and humorous illustrator, his work has appeared in national magazines, children's and humor books, newspapers, licensed products, national advertising and network television. Stromoski's greeting cards have become best-sellers for several major companies. He has won four Louie Awards for outstanding greeting card design. He has been nominated for his illustration work by the National Cartoonists Society 12 times and was awarded the Reuben division award for best greeting cards in 1995 and 1998, and for magazine gag cartoons in 1999. An NCS board member since 1997, he was elected president in 2005.
Soup to Nutz
La Cucaracha is a unique strip that provides a view of the world through the lens of its Latino characters and the mind of acclaimed creator Lalo Alcaraz, whose experiences growing up on the U.S./Mexico border inform the satirical wit of the strip.
Working Daze follows the employees trapped at MacroMicroMedia. MMM is a wanna-be software giant, and it's staffed by geeks and clueless management types. VP Rita will try anything that might make a little money (though her ideas usually don't.) Underpaid Dana carries he place and keeps it running, while overpaid Ed sleeps all day. Roy and Kathy are made for each other, and everyman Jay never knows when to keep his opinions to himself. Writer/creator John Zakour is a humor/sci-fi writer, whose work includes the Zach Johnson detective novels. Artist Scott Roberts was a longtime contributor to Nickelodeon Magazine, and is the author of the fantasy novel The Troubling Stone. John and Scott met when they both worked on the Rugrats newspaper strip.
John Zakour and Scott Roberts

domain: entertainment


text:
Posted: Wednesday, September 21, 2016. 8:03 pm CST.
By BBN Staff: Belize marked the 35th anniversary of its Independence with official ceremonies and parties nationwide on this Wednesday.
This September 21 comes at a major crossroads in Belizean history, when much of the nation is agitating for change and there is unease about where our young nation is going at this time.
Leader of the Opposition John Briceno warned that as a nation we have drifted away from the principles that National Hero George Price as Prime Minister developed on the first Independence Day in 1981 – to ensure that everyone has a successful life and contributes to the overall development of the nation. That cannot happen, he said, when so many have so little and those who have more act so arrogantly about it.
But the P.U.P. leader reminded that Belizeans have never feared the future as long as we work together to achieve our just objectives.
Meanwhile, Prime Minister Dean Barrow had no gifts to bring Belizeans this year, but he did predict an economic recovery for Belize even as he made a measured departure at the start of his Independence Day address, soberly looking at Belize’s social disconnect.
According to the Prime Minister, Belize appears to have never been less “together as one,” pointing to political as well as divisions in the labour and church sectors.
One rare area of agreement is on the issue of the Guatemalan claim, as the Prime Minister paid tribute to those who defend Belize’s territorial sovereignty and pledged the Government’s continued support.
While acknowledging that Belize does suffer from a recession currently, Barrow boldly insisted that recovery is around the corner, led by the major industries such as sugar, citrus, banana and marine products.
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text:
Jon Voight, Eric Stoltz, Ice Cube, Jennifer Lopez
Directed by Luis Llosa
PG-13 90 minutes
A documentary crew heads down the Amazon looking for the remote Shirishama Indians. Instead they encounter a snake hunter, Paul Sarone (Mr. Voight), who appropriates the group to help him hogtie a 40-foot-long serpent that is terrorizing that neck of the rain forest. Not surprising, the critter has a problem with this, erupting like a berserk fire hose, demolishing jungle outposts, gulping humans and generally behaving as if he's in ''Jaws.'' But don't count out Danny the camera man (Ice Cube) and the rest of the spunky film crew, who can splash and splutter with the best of them.
VIOLENCE Some thoroughly unattractive things happen to people, including getting doused with monkey blood in order to become bait for the snake and being swallowed and regurgitated by same. And if it's not the snake, it's one bloody donnybrook after another with Sarone.
SEX Despite the travails, one couple gets down to cases (not shown), and another pair starts to but is interrupted by a charging boar.
PROFANITY Very little.
For Which Children?
AGES 3-9 No. The film is much too scary and violent for them.
AGES 10-12 They will like the snake, the rap singer Ice Cube and the action, and though the going gets rough, most children this age can handle it.
AGES 13 and up If they haven't moved on to more sophisticated subject matter, they should be entertained. PETER M. NICHOLSContinue reading the main story


text:
Expressing yourself through personal style has always been a powerful form of self-expression. Your clothing, accessories, and possessions reflect your personality and interests, making a statement to the world about who you are. Finding unique and meaningful pieces that truly represent you can be a challenge, but not anymore with Lucki’s official merchandise shop.
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Lucki doesn’t just create merchandise; they create a sense of community that celebrates diversity and expression. The brand’s inclusive message is reflected in their diverse range of merch, making it accessible to all. It’s not just about being fashionable; it’s about embracing who you are and expressing yourself confidently.
In today’s fast-paced world, where trends come and go, finding something timeless and unique can be a challenge. Lucki offers pieces that stand the test of time, designed to be bold yet versatile enough to fit seamlessly into any wardrobe or home decor style.
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domain: geography


text:
21 February 2018
The South African Wind Energy Association (SAWEA) has issued a statement applauding the newly appointed President's commitment to stabilising state owned enterprises and Minister Gigaba's reiteration of these sentiments, in today's Budget Speech.
2 February 2018
SAWEA has responded to the Minister of Public Enterprises, Lynne Brown, giving Eskom the green light to sign the outstanding Power Purchase Agreements (PPAs) with renewable power producers.
The South African Wind Energy Association (SAWEA) together with the broader renewable power sector anticipate the conclusion of the 26 outstanding power purchase agreements (PPAs) in the first quarter of 2018.
The majority of the processes that precede the finalisation of the PPA’s were fulfilled by the IPP Office and the Preferred Bidders during mid-December. The Minister of Public Enterprises is now required to provide her approval in terms of section 54(2) of the Public Finance Management Act so that the Department of Energy (DoE) can conclude Direct Agreements with preferred bidders.
The custom-built EnergyDRIVE truck, has arrived in Cape Town, completing the first half of its 3-week wind route journey across the country, having taught thousands of learners about the benefits and uses of renewable energy technologies. The South African Wind Energy Association (SAWEA) has partnered with the Durban University of Technology and the Council for Scientific and Industrial Research (CSIR) to make this national educational road trip with the EnergyDRIVE possible.
South Africa has excellent coastal wind conditions, so it’s not surprising that the Eastern Cape has the lion’s share of operational wind farms in the country. With twelve power plants scattered across the province from Kouga through to Gibson Bay, these wind farms are contributing 34% of the country’s clean renewable power resources to the National Grid. A further upside to this nascent industry is the economic development that is taking place across the province, directly impacting on beneficiary communities.
Thursday, 14 September 2017
SAWEA and its legal counsel have welcomed clarity on NERSA process, while strongly objecting to Eskom’s lack of engagement.
More Articles ...
- ENERGYDRIVE SET TO FOCUS ON RURAL COMMUNITIES AND BUILD A WIND ROUTE
- OPPORTUNITY TO APPLY FOR SPONSORED PARTICIPATION AT WIND ENERGY CONFERENCE
- SAWEA connects Women in Industry & addresses transformation in Wind Sector
- GLOBAL WIND DAY CELEBRATES INDUSTRY ACHIEVEMENTS AND BENEFITS COMMUNITIES
- Press release: South Africans have a right to the full picture when it comes to their energy future, says wind energy organisation
- The future is blowing in the wind
- INDEPENDENT POWER PRODUCERS TAKE ON ESKOM THROUGH NATIONAL ENERGY REGULATOR
- Africa’s first academic wind industry conference an unmitigated success
- Towards 100% renewables: Wind energy conference offers forum for decisive action as a transformative year for the wind industry draws to a close
- Africa’s first academic wind energy conference boasts impressive international line up
- First wind energy-focussed academic conference in Africa receives overwhelming response to student sponsorship programme
- South Africa’s renewables industry growth is fastest in the world
- Government reiterates commitment to wind energy at leading conference
- GLOBAL WIND DAY 2016 - South Africa celebrates Global Wind Day with short film showcasing 8 amazing facts about wind energy
- Has Eskom forgotten that wind energy saved Eskom R300 million during the first half of 2015?
- Renewables outperforming on green jobs and relief for depressed communities says Energy Minister
- Leading wind energy conference, Windaba, announces 2016 dates
- New academic conference to run in collaboration with leading wind energy conference Windaba
- South Africa’s wind energy sector is already supplying more than half a million households
- China Wind Power Blows Past EU
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domain: economics


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Containers are a lighter-weight, more agile way of handling virtualization. Rather than spinning up an entire VM, a container packages together
everything needed to run a small piece of software. The container includes all the code, its dependencies, and even the operating system itself.
This approach enables applications to run almost anywhere—on a desktop computer, a traditional IT infrastructure, or in the cloud.*
Software-Defined Persistent Volume (PV) QoS Creation
Select the PV storage-class (Performance, Resilience, Secure) based on application requirements. InfoScale enables both dynamic and static provisioning of PV using native K8S commands for use by container-based applications.
Persistent Volume Scaling
Facilitates non-disruptive PV scaling of capacity and I/O for containerized applications by using Flexible Storage Sharing (FSS) that can manage both shared and shared-nothing (DAS) storage.
Persistent Volume Availability
Monitors Persistent Volumes (PV), network and server infrastructure to ensure that the application has all the resources needed to serve data. If the PV, network, or server is not available, InfoScale will notify Kubernetes to restart the pod to enable the application to continue to serve data.
CSI Snapshot and Cloning
Create a point-in-time PV copy of the data for backup and recovery using scripts or third-party apps like Velero for fast back-ups and restores.
Application Monitoring & Restart
Monitors critical application processes and notifies Kubernetes liveness probe to restarts the container in the event of an application failure.
Application State Integrity
Container applications on InfoScale Storage are protected from data corruption due to faults causing a split-brain condition. InfoScale prevents data from being written to nodes within the Kubernetes cluster which have lost membership due to faults.
Migrates existing applications to container environment by copying application data storage volumes into the Kubernetes cluster nodes.
With InfoScale, you can confidently run your stateful applications in containerized environments while providing availability and data management with these features:
Whether you’re managing hundreds of virtual machines or hundreds of thousands, Veritas delivers instant-access protection that scales, and the control you require without the complexity.
Achieving compliance across increasingly complex hybrid and multi-cloud IT requires visibility into your organization’s data and infrastructure. Veritas provides valuable insights in a single intuitive dashboard.
*Definition is from www.ibm.com
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Statistical Revolution: Data Analytics Team Optimizes Decisions Under Uncertainty
You've heard about "big data" – but the real value in data is in its use. Enter the small but powerful Data Analytics team, which is creating a statistical revolution for Pratt & Whitney.
An argument can be made that every decision at Pratt & Whitney is made under some level of uncertainty – some more than others.
That's why Erica McCullough, manager of the company's Statistics and Data Analytics group, and her team are using statistics to make the best decisions possible given that uncertainty. "Statistics is essentially a set of tools for using data to model risk and variation and, ultimately, optimize decisions," she said.
The eight-member team works with business units across the company providing decision support on projects ranging from robust component design and root-cause analysis, to Aftermarket forecasting and QN reduction. In all cases, the group's goal is to capture and account for uncertainty and variation.
"We work with our customers to capture the range or distribution of potential outcomes rather than a single, deterministic point estimate that, as we've seen in multiple cases, can drastically miss the mark," said Grant Reinman, senior fellow in Statistics and Design for Variation.
McCullough added that utilizing statistics becomes even more critical when making decisions with minimal data and lots of uncertainty, versus when you have a lot of data. "That's when it becomes even more important to look at the risks involved in your decision-making," she said.
While the group is part of the Engineering organization, it is actively working to get the entire company "thinking statistically" – whether engineering, manufacturing or financial decisions are being made – through a new Engineering Technical University (ETU) course, a Pratt & Whitney wiki page and updated Engineering Standard Work.
Steve Morford, vice president of Core Systems Engineering, echoed the importance of the group's work. "Data-based decision making is fundamental to Core Systems Engineering and beyond," he said. "The framework that statistics provides for turning data into actionable knowledge is critical to our success as an organization and a company."
An example of where the Statistics group's efforts are being brought to bear is a substantial effort currently underway involving the new Next Generation Product Family (NGPF) business and the corresponding switch to fleet management programs (FMP).
"We're using advanced statistical analysis techniques to predict how often engines will need to come off-line and planning the number of shop visits necessary," McCullough said.
"By statistically analyzing engine time on-wing, we'll be able to quantify with some certainty our shop visit rate and how that will support our FMP business," Reinman added.
Dave Houston, manager of Core Structures in Engineering, has been one of the group's most vocal customer advocates, coining the term "Statistical Revolution" within his group as a call to arms for changing the culture to one where everyone is thinking in terms of uncertainty and variation instead of single-point, deterministic answers.
"When it comes to determining the structural capability of our parts, there is uncertainty in material properties, geometry, usage and more," Houston said. "Without capturing this variation, we could be overdesigning parts and losing out on potential weight and cost improvements."
Reinman, who's been a Pratt & Whitney fellow since the early 1990s, added, "We tend to consider variation only by looking at what we believe to be the worst case. The fact is actual outcomes vary from one engine to the next, sometimes in unexpected ways, especially in large production runs. The disciplined use of statistical data allows you to engineer and develop products after exploring the entire range of possible outcomes."
He noted that when an organization asks the question, "How do I allow for variability or uncertainty in my decision making?" it should involve the Statistics team. "That should be their number one question, regardless of the decision to be made," he said.


Worry-free Linux power-downs with Anacron
Linux ordinarily uses Cron to automatically perform routine system maintenance on desktop or laptop computers, however not running Cron routinely can result in monstrously large log files and other problems. You can offload most or all of your usual daily and longer-interval Cron jobs onto Anacron enabling your computer to run regular maintenance jobs whenever the computer is powered on, even if those times are unpredictable.
(Submitted by Anonymous Sat Jul 10, 2010 )
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Copyright 1999-2005 Noel Davis. Noel also runs web sites about sailing and kayaking.
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text:
Welcome to Carolina Arthritis
Since its founding in 1991, Carolina Arthritis has been leading the way in the diagnosis and treatment of arthritis, musculoskeletal disorders, connective tissue diseases, autoimmune illnesses and osteoporosis.
Our professional physicians and associates are here for you. Schedule your next appointment today and see why we’re Wilmington’s trusted Arthritis treatment experts. LEARN MORE

domain: medical


There appear to be several bad apples in the Pilgrim’s Pride stable of facilities.
Christopher Chin probably thought it only would take a second to remove the piece of cardboard from the hopper at the Pilgrim’s Pride facility where he worked in Canton, Ga., last October. Reaching in to grab the cardboard, Chin became caught in the machine and was killed. According to OSHA investigators, the machine should have been fitted with a guard to keep employees from reaching into the machine while it was operating.
OSHA issued four serious safety violations to Pilgrim’s Pride for failing to conduct annual periodic inspections of the energy control procedures since 2005 and not providing effective machine and equipment guarding, so that workers could not enter areas of operation and be exposed to struck-by and caught-in hazards. A serious violation occurs when there is substantial probability that death or serious physical harm could result from a hazard about which the employer knew or should have known.
“Establishing safety and health programs that identify and remove hazards before a worker gets injured or sick goes to the very core of providing a safe and healthful workplace,” said Bill Fulcher, director of OSHA’s Atlanta-East Area Office. “In this case, a tragic loss resulted from equipment that could easily have been guarded.”
The agency issued two repeat safety violations, for failing to include the process needed for the removal of locks and start-up following lockout/tagout. Additionally, the electrical cords did not have an effective strain relief device. A repeat violation exists when an employer previously has been cited for the same or a similar violation of a standard, regulation, rule or order at any facility in federal enforcement states within the last 5 years. Similar violations were cited following a 2011 inspection.
Two other-than-serious violations involve failing to consider safety and health standards for the refrigeration process and not including safety systems and their functions in the refrigeration operating procedures. An other-than-serious violation is one that has a direct relationship to job safety and health, but probably would not cause death or serious physical harm.
The citations for the repeat and serious violations carry $58,755 in proposed penalties. No monetary penalties have been assessed for the other-than-serious violations.
The spokesperson for Pilgrim’s Pride, Cameron Bruett, said the company is reviewing the citations and is working with OSHA to remedy any outstanding issues.
No Pride in Safety Record for Food Company


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David Attenborough explains how a clever cuttlefish disguised himself as female so he could mate in the presence of a larger territorial male.
French Fuse remixed footage of a cat plucking a rubber band into "Seven Nation Army" while another kept beat with a litter box door.
Robyn Adele Anderson performed the iconic White Stripes song "Seven Nation Army" as a snappy bluegrass cover that includes banjo and violin.
Musician Luca Stricagnoli performed a highly percussive, string-tapping cover of the song "Seven Nation Army" by The White Stripes.
Seven googly-eyed electronic devices from The Device Orchestra performed a voltaic cover of "Seven Nation Army" by The White Stripes.
The remarkably talented musician Justin Johnson performed ten highly recognizable rock songs on a gorgeous acoustic steel slide guitar.
Jack White played an impromptu version of the game show "Name That Tune" by naming songs by The Beatles within the first few notes.
Justin Johnson performed a slide cover of The White Stripes song "Seven Nation Army" in the distinctive style of Mississippi Delta Blues.
The Kiffness joked about how "Seven Nation Army" was written as he collaborated with the angry man who repeatedly punched a car window.
Comedians Jay Foreman (previously) and Mark Cooper-Jones of Map Men take a humorous look at the history of Antartica, who actually discovered it, the questionable…


When it comes to moving forward from the loss of Pro Bowl safety
“I believe (replacing Berry) is not going to be just one person,” said the head coach. “I think it’s going be every special teams player, every defensive player, every offensive player that will have to elevate their game to kind of counterbalance the loss of a pretty neat, great kid that I think is going to be a great player in the league.”
Players like Berry can’t be replaced. You might find ingredients, but the meal doesn’t turn out the same. You’re not going to find a backup on the Chiefs roster that can do what Berry does. There isn’t a street free agent capable of completely filling Berry’s role.
Eric Berry is a rare type of athlete. He’s one of those special kinds of football players.
So where do the Chiefs go from here? They’ve lost a team captain and a difference maker, but there are still at least 15 games to play and Sunday isn’t getting any further away.
“Injuries happen in football,” teammate
Kansas City is likely to add another safety before practices begin this week. Berry still hasn’t officially gone to injured reserve, but a roster move is imminent.
There are a handful of available free agents with starting experience, but the best option for immediate bandage might come from someone already familiar with the Chiefs defensive system. Reshard Langford and Ricky Price have previously been part of the Chiefs 53-man roster, losing out on tight training camp battles for reserve positions in the secondary this training camp.
The route the Chiefs choose to take in filling the roster slot created by Berry’s season-ending injury doesn’t particularly matter. Berry can’t be replaced via a one-for-one personnel switch. Haley pointed to a collective team effort making up for the loss of the team leader, and he’s completely right.
Defensively, there isn’t a player that can be inserted into Berry’s role and be asked to perform at the same level. Premier talent doesn’t grow on trees. A pond of young Pro Bowlers aren’t available for fishing, especially in September.
Moving forward, Romeo Crennel has quite the challenge in front of him when scripting defensive game plans for the remainder of the season. He, and the rest of the Chiefs defensive staff, must figure out the best way to adapt with different personnel.
Keep in mind that we’ve never seen Crennel put together a defensive game plan without Berry being involved. Berry played every defensive snap last season and, in 2009, neither he nor Crennel were with the organization.
A true game plan defense, the script has been known to change from week to week. Last season, when visiting the Colts, the Chiefs operated almost exclusively out nickel personnel that featured
“No matter who the opponent was throughout the preseason or against Buffalo, (the Chiefs) had extra safeties on the field as part of their scheme,” Voice of the Chiefs Mitch Holthus said when analyzing the safety situation on Chiefs LIVE! “Even with Berry on the field next to Lewis, McGraw would be on the field as kind of a nickel back. Coming into the season they had plans for using multiple safeties.”
Maybe the schematic changes won’t be drastic. A younger, unproven player could always surprise. But however it happens, replacing Berry is going to take a collective effort.
On Sunday, McGraw replaced Berry in the base sets.
“Now we’ll see if Romeo has to adjust from that,” Holthus said. “They’re playing a team this week that plays out of a three tight end set. Last week, against Tampa Bay, (Detroit) played out of a three tight end/one running back set which puts even more of a burden on your safeties because they’re tight ends are good.”
On another note…one thing I try to keep from doing is making apples to oranges comparisons. But for a number of reasons, I can’t get the 2003 Super Bowl champion New England Patriots out of my head.
Aside from being embarrassed 31-0 by Buffalo in the Week One “Lawyer Milloy Bowl,” the Patriots had to deal with an outbreak of injuries throughout the early portions of the 2003 season.
Injuries were such a problem that the Patriots switched from a 3-4 defense to a 4-3 scheme at midseason because of personnel losses. Injuries hit 15 key contributors over the first three weeks of the season. Crennel, of course, was New England’s defensive coordinator at the time.
That Patriots team was in a much different place than the Chiefs are in 2011. For starters, the Patriots were coming off a Super Bowl championship in 2001 and had a core group of players remaining from that championship run.
Apples and oranges indeed, but the Patriots were still able to adapt to the hand that was unexpectedly dealt. They answered on offense, defense and special teams.
Successfully moving forward from Berry’s injury will require a team-wide effort.


text: You gingerly walk through the caves and approach the top of the cavern. You feel remarkable! After all, YOU ARE THE CHAMPION! However, it feels as though you are being watched. You look up, and suddenly your blood freezes at the sight of a single figure standing just up ahead. He is dressed in a yellow tunic, and white pants. He appears to be pulling on something. You muster up the courage and walk closer. He notices you, and pulls a sword from the stone. In response, you pull your sword from your scabbard. Hence, The Battle of Ages begins!


text:
Campus Map: There's An App For That
January 19, 2011
The UNH campus map application helps users get directions from and to any location on campus; identify and locate UNH buildings and landmarks; learn history and discover statistics about UNH; and access a vast amount of information including parking, ATM and dining locations.
The application is compatible with iPhone, iPod touch, and iPad. (Requires iOS 3.2 or later). It's also free and can be downloaded via the iTunes Store.
Check out the images below to get an idea of the information the app provides.


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The purpose of this study is to investigate the modulatory effects of acute and chronic nicotine exposure on reinforcement learning for monetary rewards. Nicotine, the primary addictive component in tobacco, is a weak reinforcer that does not induce robust euphoric effects like other drugs of abuse (e.g., cocaine, alcohol), yet produces a higher rate of dependence among tobacco users than among users of other addictive drugs. A potential explanation of this paradox is that nicotine amplifies the salience of other stimuli that have some incentive value and prolonged exposure could result in dysregulated reward processing. Reinforcement learning is the process of learning what actions to take to maximize reward, and may be the mechanism by which nicotine amplifies the incentive value of other stimuli. A key component of reinforcement learning is the prediction error, which is the difference between the actual and the expected reward outcome. Neuroimaging studies have shown that BOLD activation in the mesocorticolimbic pathway correlates with prediction errors during reinforcement learning paradigms. The overarching aim of this proposal is to use neuroeconomic models of reinforcement learning to study the acute and chronic effects of nicotine on motivational behavior and prediction error-related neural activation using a task with probabilistic outcomes and fMRI. Nonsmokers will be scanned following acute nicotine and placebo administration, and smokers will be scanned following normal smoking behavior and 24-hours of smoking abstinence. This proposal will bridge the gap in the literature between neuroeconomic and addiction research and these results will inform whether the initiation and maintenance of smoking behavior could be facilitated by the effects of nicotine on reinforcement learning. The Principal Investigator (PI) will be mentored and advised by a team of faculty with expertise in nicotine psychopharmacology, fMRI, and neuroeconomics. The institution provides exceptional facilities and departments dedicated to these three fields of research. In addition to learning how to design and conduct clinical nicotine research, this training plan with provide the PI with the opportunity to integrate several distinct, yet overlapping, fields of research in order to explore new approaches to understanding the etiology of nicotine addiction. This proposal builds upon the PI's previous pharmaco-MRI experience, and will allow her to develop new skills while contributing to research on the effects of nicotine on decision-making behavior in humans. The education, training, and research goals described in this proposal will provide the applicant with the research experience necessary to become a successful independent investigator.
Cigarette smoking is a leading cause of death and disability in the United States, yet nicotine psychopharmacology does not entirely explain the addictiveness of tobacco. An important moderating factor may be the ability of nicotine to amplify the incentive value of other rewarding stimuli. This may play a critical role in the initiation, maintenance, and relapse of tobacco use. This study will lead to a better, more precise understanding of how nicotine shapes reward processing, which is believed to contribute to its abuse liability.
|Addicott, Merideth A; Daughters, Stacey B; Strauman, Timothy J et al. (2018) Distress tolerance to auditory feedback and functional connectivity with the auditory cortex. Psychiatry Res Neuroimaging 282:1-10|
|Addicott, Merideth A; Sweitzer, Maggie; McClernon, F Joseph (2018) The Effects of Nicotine and Tobacco use on Brain Reward Function: Interaction with Nicotine Dependence Severity. Nicotine Tob Res :|
|Addicott, M A; Pearson, J M; Sweitzer, M M et al. (2017) A Primer on Foraging and the Explore/Exploit Trade-Off for Psychiatry Research. Neuropsychopharmacology 42:1931-1939|
|Addicott, Merideth A; Oliver, Jason A; Joseph McClernon, F (2017) Nicotine increases anterior insula activation to expected and unexpected outcomes among nonsmokers. Psychopharmacology (Berl) 234:1145-1154|
|McClernon, F Joseph; Conklin, Cynthia A; Kozink, Rachel V et al. (2016) Hippocampal and Insular Response to Smoking-Related Environments: Neuroimaging Evidence for Drug-Context Effects in Nicotine Dependence. Neuropsychopharmacology 41:877-85|
|McClernon, Francis Joseph; Froeliger, Brett; Rose, Jed E et al. (2016) The effects of nicotine and non-nicotine smoking factors on working memory and associated brain function. Addict Biol 21:954-61|
|McClernon, F Joseph; Addicott, Merideth A; Sweitzer, Maggie M (2015) Smoking abstinence and neurocognition: implications for cessation and relapse. Curr Top Behav Neurosci 23:193-227|
|Addicott, Merideth A; Pearson, John M; Kaiser, Nicole et al. (2015) Suboptimal foraging behavior: a new perspective on gambling. Behav Neurosci 129:656-665|
|Addicott, Merideth A; Sweitzer, Maggie M; Froeliger, Brett et al. (2015) Increased Functional Connectivity in an Insula-Based Network is Associated with Improved Smoking Cessation Outcomes. Neuropsychopharmacology 40:2648-56|
|Addicott, Merideth A; Pearson, John M; Froeliger, Brett et al. (2014) Smoking automaticity and tolerance moderate brain activation during explore-exploit behavior. Psychiatry Res 224:254-61|
Showing the most recent 10 out of 12 publications


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text:
Attention deficit hyperactivity disorder (ADHD)
University Of Phoenix
Breyer, J. L., Lee, S., Winters, K. C., August, G. J., & Realmuto, G. M. (2014). A longitudinal study of childhood ADHD and substance dependence disorders in early adulthood. Psychology of Addictive Behaviors, 28(1), 238-246. Retrieved from doi:http://dx.doi.org/10.1037/a0035664
This study shows the findings in which link childhood attention deficit hyperactivity disorder (ADHD) to adulthood substance abuse. The authors describe the association of several psychosocial problems in early adulthood in children who have ADHD. The focus on this study is to compare the relationship of using treatment medications in childhood to the development of a substance abuse disorder later in life. The symptoms based on previous research shows that the relationship between using substances such as alcohol, marijuana and cocaine during adolescent years are higher that non-ADHD peers. The gap between the actual first use and the development of the substance abuse disorder is shorter than those who never received medication treatment.
Deault, L. C. (2010). A systematic review of parenting in relation to the development of comorbidities and functional impairments in children with attention-Deficit/Hyperactivity disorder (ADHD). Child Psychiatry and Human Development,41(2), 168-92. doi:http://dx.doi.org/10.1007/s10578-009-0159-4
Here the study discusses the systematic reviews previous research in which finding the relation of parenting to the impairments in children with ADHD. This article reviews current research in the area of parenting and development in children with ADHD. The goal is to determine what parents can do to help make a positive impact in their child’s development. The author pulled apart several different research studies and compared parenting variables and relationship between the parent and child. The review shows and compares different styles of parenting and the effect on the child. They show how dysfunctional parenting enables the child to lack control of ADHD symptoms.
Lerner, M., M.D., & Wigal, T., PhD. (2008). Long-term safety of stimulant medications: Used to treat children with ADHD. Journal of Psychosocial Nursing & Mental Health Services, 46(8), 38-48. Retrieved from http://search.proquest.com/docview/225531707?accountid=35812
This journal article explains the long term risks of stimulant therapy how patients tolerate treatment depends on the individual and not all children with ADHD. The authors describe possible side effects as well as the risk that goes along with each one. This journal goes into detail about methylphenidate and the statistical significance of different studies and outcomes. In addition to weight of benefits and risks, ongoing safety monitoring medication intake and consistency is the most important responsibility of prescribing clinicians.
Grizenko, N., Qi Zhang, D. D., Polotskaia, A., & Joober, R. (2012). Efficacy of Methylphenidate in ADHD Children across the Normal and the Gifted Intellectual Spectrum. Journal of the Canadian Academy of Child and Adolescent Psychiatry, 21(4), 282–288.
In Canada, this experimental study shows the difference between children with ADHD who took Methylphenidate who had either a low IQ, normal IQ or a high IQ and the response difference in participants as well. The variables were changed and the possibility of casual relationship in experiment. The results showed no significant differences between them and explanation of children symptoms being less than children with high IQ, and the validity and reliability of previous research was in line with previous studies.
Weinstein, C. S., Apfel, R. J., & Weinstein, S. R. (1998). Description of mothers with ADHD with children with ADHD.Psychiatry, 61(1), 12-9. Retrieved from http://search.proquest.com/docview/220699156?accountid=35812
In this study, the researchers describe mothers with ADHD and how parenting a child with ADHD can be difficult and viewed by society as immature but they did experimental test showing the specific parent groups without ADHD were better at performing motherly duties than those with ADHD. They describe how the failures of personal child raising is not any fault of the mothers with ADHD because the person is not capable of doing something that is normal for the non-ADHD mother. This article shows that the information lacks the ability to provide personalized treatment for those who need treatment for family conformed to the needs of mother and child working in a positive direction.

domain: psychology


text:
A new map of North America with the West India Islands: divided according to the preliminary articles of peace, signed at Versailles, 20, Jan. 1783; wherein are particularly distinguished the United States and the several provinces, governments & ca. which compose the British dominions / laid down according to the latest surveys and corrected from the original materials of Goverr. Pownall, Membr. of Parliamt., 1783.
from Charts and maps Governor Pownall,
Map of the United States of America, the British Provinces, Mexico, the West Indies and Central America, with part of New Granada and Venezuela
1 : 6400000 Colton, George Woolworth Colton, J. H. (Joseph Hutchins)
A new map of the north parts of America claimed by France under ye names of Louisiana, Mississipi, Canada and New France, with ye adjoyning territories of England and Spain ... / ... laid down according to the newest and most exact observations by H. Mol
from The world described, or, A new and correct sett of maps : shewing the kingdoms and states in all the known parts of the earth, with the principal cities, and most considerable towns in the world ... / ... by Herman Moll, geographer ...
Regni Mexicani seu Novae Hispaniae, Ludovicianae, N. Angliae, Carolinae, Virginiae, Pensylvaniae, necnon insvlarvm archipelagi Mexicani in America Septentrionali / accurata tabula exhibita a Ioh. Baptista Homanno.
from Parts John Baptista Homann, S.,
Regni Mexicani seu Novae Hispaniae, Ludovicianae, N. Angliae, Carolinae, Virginiae, Pensylvaniae, necnon insularum archipelagi Mexicani in America Septentrionali / accurata tabula exhibita à Ioh. Baptista Homanno.
from Charts and maps John Baptista Homann, S.,

domain: library