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An article in yesterday’s Wall Street Journal discussed how more and more general surgeons are shifting from private practices to temporary assignments as a result of the economic downturn, rising overhead costs and declines in reimbursements.
So much so that “general surgery is now among the fastest growing areas of a temporary medical staffing undystry that’s expected to double to $2.1 billion in 2009 from five years ago, according to Locumtenens.com.”
The WSJ article, Surgeon Shortage Pushes Hospitals to Hire Temps, goes on to say that “temporary surgeons used to be mostly older physicians who wanted a lighter workload, or those fresh out of training, still deciding where to put down roots. But today, more are midcareer people.”
The WSJ estimated that it can cost a hospital up to $1500/day, plus travel and lodging expenses for a temporary surgeon to come in and perform scheduled procedures and emergency operations. But as hospitals continue to face a shortage in nurses and doctors, utilizing locum tenens staffing is quickly becoming one of the only options available.

domain: medical


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How WPI is boosting Worcester’s startup scene
Worcester Polytechnic Institute has been here since 1865. And it’s giving a big boost to the local startup scene thanks to the talent that it’s attracted, the intellectual property it has developed, and its efforts to license that IP to startups that are trying to transform these great ideas into growing revenues.
Indeed, some of the startups using WPI technology are in or near Worcester.
This is a summary of the good news I learned from Todd Keiller, WPI’s director, intellectual property and innovation, who comes from a background in in “real world.”
As he said in a Sept. 5 interview, “I came to WPI six years ago this coming October. I have been doing this kind of stuff since the early 1990s. Before coming to WPI I spent 10 years at Corning as a marketing manager for medical products, worked at a startup that went from $1 million to $10 million in revenue in a year and a half and was later hired by Brigham & Women’s Hospital as VP of ventures. It was a shock to go from monthly performance reviews in the startup world to annual ones at Brigham & Women’s. With an undergraduate degree in economics and an MBA, I was the first person with a business background in that role. From there I went to University of Vermont, where I started its technology licensing program. I came to WPI six years ago – in part because my wife and I are Massachusetts people and did not want to live full time in Vermont.”
WPI’s efforts to license its IP have taken a turn for the better since Mr. Keiller’s arrival. As he said, “When I came here there were 500 patent applications and zero licenses. Today we have 44 licenses to 13 companies — mostly startups. It is expensive to apply for patents, and we found that there were some applications for which the experiments had failed, so we were able to focus on the most viable ones. We now have 140 active cases, of which a third are licensed — this is very high compared to most schools. In the fiscal year ending June 30, 2017, we had licensed to six startups, and we expect six more in the current fiscal year.”
WPI has found that the best way to commercialize its IP is to license it to startups rather than to a large company.
“In order to know whether our IP represents a good business opportunity, it needs to be in a startup that can get an SBIR grant or funds from friends and family to investigate whether the technology can solve a real customer problem. Two of our companies did that and now are closing in on sizeable private investments. A third one got started, failed, and pivoted. While we are quite excited about how some of the companies are moving along and think that they have the potential to generate hundreds of thousands of licensing revenue, it is too early to tell how much licensing revenue they’ll generate for WPI,” Mr. Keiller said.
Two of the more interesting startups are Sports Engineering, which makes athletic shoes that help prevent ACL tears, and Battery Resourcers, which recycles lithium ion batteries.
“Sports Engineering was developed with Professor Brown and a student on the women’s soccer team. She produced a video of a soccer player wearing the shoes — you can see the sole giving as she twists. The company got funding from an angel investors and is now talking [about possible partnerships] with Nike and New Balance. Battery Resourcers was started by a PhD student two years ago. The company made it to the MassChallenge finals and got funding from the National Science Foundation to conduct 100 customer interviews. It also got two rounds of SBIR funding and a round of financing from a battery company. It was operating out of an incubator in Grafton, where it had a pilot plant and is moving to Marlboro,” Mr. Keiller said.
WPI also has several ways to help its students develop their entrepreneurial ambitions.
”We have entrepreneurship programs at the business school, The Keen Foundation runs workshops for the students, and 50 local alumni show up for monthly Technology Advisors Network meetings. Student teams present to the advisors and get feedback,” Mr. Keiller said.
While not all of the 16 startups that have licensed WPI’s technology are based in Worcester, most are in-state.
“Two of the companies are located outside of the state, but the rest are in Worcester or in the region,” Mr. Keiller said.
I hope someday to write about one of these Worcester-based companies going public.
Peter Cohan of Marlboro heads a management consulting and venture capital firm, and teaches business strategy and entrepreneurship at Babson College. His email address is firstname.lastname@example.org.

domain: news


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Potential conflict of interest: Nothing to report.
Supported by funding from the National Research Program for Biopharmaceuticals (NSC 101-2325-B-001-011) and the National Science Council (NSC101-2320-B-001-029-MY3) of Taiwan.
Eukaryotic translation initiation factor 3 subunit I (eIF3I) with transforming capability is often overexpressed in human hepatocellular carcinoma (HCC) but its oncogenic mechanisms remain unknown. We demonstrate that eIF3I is overexpressed in various cancers along with activated Akt1 phosphorylation and kinase activity in an eIF3I dose-dependent manner. A novel eIF3I and Akt1 protein interaction was identified in HCC cell lines and tissues and was required for eIF3I-mediated activation of Akt1 signaling. Expression of either antisense eIF3I or dominant negative Akt1 mutant suppressed eIF3I-mediated Akt1 oncogenic signaling and various other tumorigenic effects. Oncogenic domain mapping of the eIF3I and Akt1 interaction suggested that the C-terminal eIF3I interacted with the Akt1 kinase domain and conferred the majority of oncogenic functions. In addition, eIF3I interaction with Akt1 prevented PP2A dephosphorylation of Akt1 and resulted in constitutively active Akt1 oncogenic signaling. Importantly, concordant expression of endogenous eIF3I and phospho-Akt1 was detected in HCC cell lines and tissues. Treatment of eIF3I overexpressing HCC cells with the Akt1 specific inhibitor API-2 suppressed eIF3I-mediated tumorigenesis in vitro and in vivo. Conclusion: We describe a constitutive Akt1 oncogenic mechanism resulting from interaction of overexpressed eIF3I with Akt1 that prevents PP2A-mediated dephosphorylation. Overexpression of eIF3I in HCC is oncogenic and is a surrogate marker and therapeutic target for treatment with Akt1 inhibitors. (HEPATOLOGY 2013;)
Hepatocellular carcinoma (HCC) is the most common liver malignancy and the sixth leading cause of cancer deaths worldwide. The major risk factors for developing HCC are chronic viral hepatitis, alcoholism, nonalcoholic fatty liver disease, and exposure to environmental agents such as aflatoxins.1 In addition to hepatitis B virus (HBV) endemic countries in sub-Saharan Africa and Eastern Asia, the increasing incidence of hepatitis C virus (HCV) infection in Western countries and persistent HBV infection in developing countries resulted in an estimated 748,300 new liver cancers and 695,900 cancer deaths worldwide annually.2 Despite the available treatments, the overall survival of HCC patients remains poor.3 Targeted therapy with a US Food and Drug Administration (FDA)-approved multiple kinase inhibitor, sorafenib, was shown to suppress tumor growth and angiogenesis but displayed a marginal benefit, with an average prolonged survival for 3-4 months in advanced HCC patients.4 Therefore, new biomarkers and therapeutic options are urgently required for improving the survival of HCC patients.
Deregulation of messenger RNA (mRNA) translation, especially at the rate-limiting step of translational initiation, results in a global increase of protein synthesis or enhanced translation of selected oncogenic mRNAs, which may play an important role in cancer development and progression.5, 6 At least nine eukaryotic initiation factors (eIFs) were identified for initiation of protein translation. Among them, eIF4E, the best studied of the eIFs, is frequently overexpressed in human cancers and functionally correlates to cellular transformation, tumorigenesis, and metastasis.7, 8 Overexpression of eIF4E in cancer cells can stimulate phosphorylation of 4EBP through the PI3K/Akt1/mTOR pathway, release eIF4E from 4EBP sequestration to bind to the 5′ cap of mRNAs, and selectively unwind the secondary structures at the 5′ untranslated region (UTR) to enable aberrant protein translation of oncogenic and metastatic genes.9, 10 In the PI3K/Akt1/mTOR pathway, the serine-threonine protein kinase Akt1 is the major regulator of protein synthesis by regulating every stage of the multistep process of mRNA translation from ribosome biogenesis, translation initiation to translation elongation.5, 11 Aberrant activation of Akt1 has been widely reported in many cancers, and resulted in promotion of cancer cell metabolism, growth, proliferation, survival, and angiogenesis.12, 13 Current therapeutic efforts targeting aberrant translational control are mainly focused on inhibition of eIF4E hyperactivation to block initiation of translation and these approaches are currently in phase I and II clinical trials.14
The eIF3 protein complex is the largest eIF and consists of 13 subunits named eIF3a to eIF3m.15 Various eIF3 subunits were reported to be abnormally expressed in malignant tumors and demonstrated to play important roles in tumorigenesis.16, 17 eIF3I (also known as eIF3S2) was initially identified as a type II transforming growth factor beta (TGF-β) receptor interacting protein (TRIP-1) and functions as a negative regulator for the TGF-β signaling pathway.18 eIF3I overexpression is commonly observed in several cancer types.19-21 Overexpressing eIF3I (or TIF3, a mouse ortholog with 99% amino acid similarity) in NIH3T3 cells enhanced colony forming capability in vitro and tumor xenografts in nude mice.17, 22 Moreover, eIF3I displayed strong anchorage-independent growth (AIG) in HCC cells and was up-regulated in 62% (28/45) of HCC tumors as compared with adjacent nonmalignant tissues, suggesting that eIF3I plays an important role in HCC progression.19
Cell Lines, Constructs, Antibodies, Gene Expression Analysis, and Tumorigenic Assays.
Details and experimental protocols are provided in the Supporting Information.
In Vitro Akt1 Kinase Assay.
In vitro Akt1 kinase activity was measured by Akt1 kinase assay kit (Cell Signaling) and described in the Supporting Information.
In Vitro Akt1 Dephosphorylation Assay.
HCC Cells were transiently transfected with HA-Akt1, Flag-wild-type eIF3I, Flag-mutant eIF3I (amino acids 1-174), or vector control. After serum starvation, these transfected cells were treated with IGF-1 for 45 minutes and lysed in isotonic buffer (142.5 mM KCl, 5 mM MgCl2, 10 mM HEPES, 0.1% Triton X-100, 1 mM PMSF, and 1× protease inhibitor). Equal amounts of cell lysates were treated with anti-HA antibody overnight at 4°C for IP assay. After washes, the pellets were reacted with PP2A proteins in buffer B (20 mM imidazole, 150 mM NaCl, 14.4 mM β-mercaptoehanol, 1 mM PMSF and 1× protease inhibitor) at 30°C for 1 hour. This reaction was terminated by 6× sample buffer and western blot analysis for phospho-Akt1 expression.
PP2A Immunoprecipitation Phosphatase Assay.
PP2A phosphatase activity was measured by PP2A immunoprecipitation phosphatase assay kit (Millipore) and described in the Supporting Information.
In Vivo Xenograft Tumor Formation Assay.
The animal protocol was approved by the Animal Safety Committee of Academia Sinica. A total of 1 × 106 HepG2 cells were mixed with matrigel (356237; BD) and subcutaneously injected into BALB/c NU mice. Tumor volumes were measured weekly (volume = length × width 2 × 0.52). When tumor volume reached >20 mm3, mice were randomly divided into two groups and intravenously injected with Akt1 inhibitor API-2 (API-2/DMSO at 1 mg/kg/day) and placebo (dimethyl sulfoxide, DMSO) daily.
Overexpression of eIF3I-Activated Akt1 Signaling in Cancers.
Because eIF3I overexpression was shown in some cancers including HCC, we first performed in silico microarray analysis to detect aberrant eIF3I expression in cancers. We found that overexpression of eIF3I existed in HCC, cervical, and colon cancers versus the normal tissues and also in metastatic versus primary melanoma (Fig. 1A). To elucidate the molecular mechanism of eIF3I overexpression-mediated tumorigenesis, we examined activation of crucial HCC signal mediators including STAT3, ERK, and Akt1.23-25 Only phospho-Akt1 (Ser473) was significantly increased in an eIF3I dose-dependent manner in 293T cells (Fig. 1B). An eIF3I-induced increase in phospho-Akt1 was observed in two HCC cells, HepG2 and SK-Hep1, stably expressing eIF3I and reversed by silencing endogenous eIF3I with antisense eIF3I (eIF3I-AS) (Fig. 1C). To determine whether the eIF3I-enhanced phospho-Akt1 could further activate its kinase activity, we examined phosphorylation of direct downstream substrates of Akt1 in HCC cells including GSK-3α/β and FoxO1/FoxO3a. In these cells, increased phosphorylation forms of GSK-3α and FoxO1/FoxO3a were observed (Fig. 1D). Conversely, knockdown of endogenous eIF3I by antisense or cotransfection of eIF3I with dominant negative Akt1 (KM-Akt1, K179M) resulted in decreased expression of phospho-GSK-3α and phospho-FoxO1/FoxO3a (Fig. 1D). The eIF3I-induced Akt1 kinase activity was further confirmed by in vitro Akt1 kinase assay. Coexpression of eIF3I with Akt1 significantly activated Akt1 kinase activity, as evidenced by the increased intensity of phospho-GST-GSK-3α/β (Fig. 1E). Collectively, our results indicated that overexpression of eIF3I activates phospho-Akt1 and enhances its kinase activity in HCC cells.
Akt1 Kinase Activity Is Required for eIF3I-Mediated Tumorigenic Properties.
Given that overexpression of eIF3I can enhance Akt1 kinase activity, we next asked whether Akt1 plays a role in eIF3I-induced oncogenesis. Indeed, overexpression of eIF3I in HepG2 cells enhanced cell proliferation, increased colony numbers in AIG, and enlarged tumor volume in xenografts (Fig. 2A-C). In contrast, knockdown of endogenous eIF3I by eIF3I-antisense diminished the above-mentioned oncogenic properties. To further determine the involvement of Akt1 signaling pathway, coexpression of KM-Akt1 with eIF3I not only decreased the level of eIF3I-enhanced expression of phospho-GSK-3α and phospho-FoxO1/FoxO3a but also mitigated eIF3I-mediated tumorigenic effects (Figs. 1D, 2A-C). Since eIF3I was originally identified as a type II TGF-β receptor-interacting protein-1 (TRIP-1) and since TGF-β-induced apoptosis has been shown to be involved in regulation of early-stage HCC, we tested the effect of overexpressing eIF3I on TGF-β-induced apoptosis. Hep3B cells displayed apoptotic effects after serum starvation or the combination of serum starvation with TGF-β (Fig. 2D). These effects were diminished when Hep3B cells overexpressed eIF3I. Conversely, knockdown of endogenous eIF3I by eIF3I-antisense further increased cellular apoptosis. In addition, coexpression of KM-Akt1 with eIF3I reversed the eIF3I-induced antiapoptotic effect. Together, our results suggested that overexpression of eIF3I attenuated TGF-β-induced apoptosis and promoted HCC tumorigenic effects through activation of the Akt1 signaling pathway.
eIF3I Interacts with Akt1 in an Akt1 Kinase Activity-Dependent Manner.
With the structural feature of four WD40 domains and its ability to activate Akt1 kinase activity, we examined the possibility of eIF3I modulated Akt1 activity through a protein-protein interaction. Akt1 was detected in the endogenous eIF3I immunocomplex by using the endogenous coimmunoprecipitation assay. Reciprocally, pull-down of endogenous Akt1 also coprecipitated eIF3I (Fig. 3A). The endogenous interaction of eIF3I and Akt1 was further confirmed in two human HCC tumor and corresponding adjacent nonmalignant tissue paired samples (Fig. 3B). When compared with their corresponding adjacent nonmalignant tissue, stronger expression of eIF3I, Akt1, and phospho-Akt1 were detected in tumor tissues and resulted in higher immunoprecipitated interacting proteins. Our results suggested that overexpressed eIF3I forms a complex with Akt1.
Because Akt1 is the downstream modulator of several kinases, we next asked whether the phosphorylation level of phospho-Akt1 could further influence the interaction between Akt1 and eIF3I. First, We treated protein lysates of eIF3I and Akt1 transfected Hep3B, HepG2 and 293T cells with calf intestinal alkaline phosphatase (CIP) to dephosphorylate Akt1 and examined the protein interactions in the eIF3I immunocomplex (Fig. 3C; Supporting Fig. 1A). We found that decrease of Akt1 phosphorylation reduced eIF3I interaction with Akt1. By contrast, we treated eIF3I and Akt1 transfected HCC and 293T cells with IGF-1 (insulin-like growth factor-1) to activate Akt1 kinase activity. We found that IGF-1 treatment resulted in increased phspho-Akt1 expression, leading to increased precipitation of Akt1 in the eIF3I-immunocomplex (Fig. 3C; Supporting Fig. 1B). Finally, we asked whether Akt1 kinase activity is required for eIF3I and Akt1 interaction by comparing the eIF3I-binding ability to the wild-type Akt1 and the kinase-deficient mutant KM-Akt1. After validation of phospho-Akt1 expression and its kinase activity by measuring the downstream phospho-GSK-3α expression of wild-type Akt1 and KM-Akt1 (lower panel, Fig. 3D), we found that the Akt1 kinase-deficient mutant (KM-Akt1) displayed a significant reduction when compared with wild-type Akt1, and of eIF3I-binding capability in both the eIF3I-immunocomplex and the Akt1-immunoprecipitated complex (upper panel, Fig. 3D). Taken together, our results strongly indicated that eIF3I interacts with Akt1 through an Akt1 kinase activity-dependent manner.
Domain Mapping Reveals eIF3I C-Terminal End Possesses Akt1 Interaction, Activation, and Oncogenic Functions.
Next, we dissected the interacting domains of eIF3I and Akt1 to ask whether the interaction is essential for eIF3I-mediated tumorigenic properties (Fig. 4A,B). To dissect the interacting domains on eIF3I (Fig. 4A), a full-length and four truncated mutants of eIF3I including a.a. 1-174 (amino acid 1∼174 fragment containing clone), a.a. 1-216, a.a. 40-327, and a.a. 175-327 were constructed to examine their binding ability with Akt1. Most of eIF3I constructs were able to bind to Akt1 except a.a. 1-174 mutant, indicating that the C-terminal region (a.a. 175-327) of eIF3I is responsible for Akt1-binding (Fig. 4A). Reciprocally, a series of Akt1 truncated mutants including a.a. 1-148, a.a. 1-412, a.a. 149-412, and a.a. 149-480 were constructed and examined for the eIF3I-binding ability (Fig. 4B). The full-length and most Akt1 truncated mutants maintained eIF3I-binding ability except a.a. 1-148 construct failed to interact with eIF3I. Our results suggested that the kinase domain of Akt1 (a.a. 149-412) is required for eIF3I interaction (Fig. 4B).
To determine the tumorigenicity of eIF3I domains, we expressed two eIF3I truncated mutants, the N-terminal Akt1-binding deficient mutant (a.a. 1-174) and C-terminal Akt1-binding mutant (a.a. 175-327) in HepG2 cells. Wild-type and C-terminal eIF3I activated phospho-Akt1 as compared to the mock control, whereas N-terminal eIF3I lost this effect (Fig. 4C). Consistently, although C-terminal eIF3I with some decreased tumorigenic effects, both wild-type and C-terminal eIF3I maintained the oncogenic capabilities to promote cell proliferation, enhance AIG ability, and increase tumor volume in nude mice but the N-terminal eIF3I lacked these properties (Fig. 4D-F). Taken together, our results demonstrate that the ability of eIF3I to interact with Akt1 determines its activation of Akt1 signaling pathway and oncogenic effects.
eIF3I Enhances Phospho-Akt1 Activation by Preventing PP2A-Mediated Akt1 Dephosphorylation.
To further understand the molecular mechanism of overexpressed eIF3I increased phospho-Akt1 expression and interaction in a kinase activity-dependent manner, we examined the potential involvement of a reported Akt1 negative modulator, a serine/threonine protein phosphatase 2A (PP2A).26 Our results showed that the incubation of immunoprecipitated-Akt1 with PP2A indeed resulted in a considerable reduction in phospho-Akt1 (Fig. 5A). However, coexpression of wild-type eIF3I disrupted PP2A-mediated decrease of phospho-Akt1 but not the Akt1-binding deficient N-terminal eIF3I (a.a. 1-174) mutant (Fig. 5A). Since PP2A has been demonstrated to form a complex with Akt1 to inactivate Akt1 kinase activity,27 we hypothesized that eIF3I inhibits PP2A-mediated Akt1 dephosphorylation through interference of Akt1-PP2A binding. As expected, eIF3I overexpression markedly blocked Akt1-PP2A binding, whereas no significant effect was found on the Akt1-binding deficient N-terminal eIF3I mutant (a.a. 1-174) (Fig. 5B). To rule out the possibility that eIF3I directly regulates PP2A phosphatase activity, we measured PP2A phosphatase activity in cells overexpressing mutant and wild-type eIF3Is. No significant difference of PP2A activity was observed between mock control, wild-type, and N-terminal (a.a. 1-174) mutant of eIF3I (Fig. 5C). PP2A-B and PP2A-C retained their capability to interact with and modulate Akt1 (Supporting Fig. 2). To further verify these results in HCC cells, we found that the eIF3I-AS knockdown eIF3I decreased Akt1-immunoprecipitated eIF3I and phospho-Akt1 but increased the pull-down of Akt1-interacted PP2A (Fig. 5D). Similarly, overexpressed eIF3I in two human HCC tumor samples decreased Akt1-immunoprecipitated PP2A when compared to that of corresponding adjacent nonmalignant liver samples (Fig. 3B, bottom panel). These results suggest that eIF3I associates with phospho-Akt1 to prevent PP2A binding and thereby abrogates PP2A-mediated Akt1 dephosphorylation (Fig. 5E).
Endogenous eIF3I and Phospho-Akt1 Are Concordantly Expressed in HCC Cell Lines and Tissues.
With the strong functional relationship between eIF3I and phospho-Akt1 established, we next explored the concordance of expression of these two proteins in HCC cell lines and tumor specimens. Of the 10 HCC cell lines that showed disconcordant expression, except SK-Hep1 and HCC36, eight demonstrated concordance of eIF3I and phosphor-Akt1 expression. Four dual high expressions (PLC5, Mahlavu, HA22T, and Hep3B) showed strong colony-forming capability and four dual low expressions (Tong, HepG2, Huh6, and Huh7) displayed fewer numbers of colonies in soft agar assays (Fig. 6A).
Next, we examined the concordant expression of eIF3I and phospho-Akt1 protein levels by immunohistochemistry (IHC) staining on 59 HCC specimens (Supporting Table 1). Strong expression of eIF3I and phospho-Akt1 were found in 76% (45/59) and 54% (32/59) HCC tumor tissues, respectively (Fig. 6B, representative IHC images of HCC tumor tissues). The high proportion of eIF3I up-regulation at the protein level is consistent with a previous study that showed higher RNA expression in 60%∼70% HCC cases with no statistical association with clinicopathological features of HCC samples.19 Interestingly, we found a significant concordant expression of eIF3I and phospho-Akt1 in the same HCC tumor tissues (Fig. 6B, r = 0.7172, P < 0.01). Together, our results suggest that phospho-Akt1 expression was significantly correlated with eIF3I protein expression in HCC cell lines and tissues.
Overexpressed eIF3I Is a Surrogate Marker for Treating HCC Patients with Akt1 Kinase Inhibitor API-2.
With strong concordance of eIF3I and phospho-Akt1 expression in HCC tissues, we tested whether overexpressed eIF3I could serve as a theranostic biomarker for suppressing eIF3I-induced oncogenic properties with Akt1 specific inhibitor API-2.28 Our results showed that the decrease of phospho-Akt1 and its interaction with eIF3I were observed in an API-2 dose-dependent manner (Fig. 7A,B), suggesting that API-2 treatment effectively inhibited eIF3I-induced activation of Akt1. Furthermore, API-2 treatment of eIF3I overexpressing HepG2 cells significantly attenuated cell proliferation in comparison to the vector control (Fig. 7C,D) and decreased colony numbers in soft agar (Fig. 7E). Moreover, treatment of API-2 significantly suppressed eIF3I overexpressing HepG2 xenograft tumor volume in nude mice (Fig. 7F). Altogether, our results indicated that Akt1 kinase activity is essential for eIF3I-exerted oncogenic effects. eIF3I is a potential theranostic biomarker for treatment of HCC patients with Akt1 inhibitor API-2 for suppression of eIF3I-induced HCC tumorigenesis.
Aberrant activation of Akt1 has been reported in various cancers through studies on members of the PI3K/Akt1/PTEN pathway. In other studies, loss or down-regulation of PTEN,29 amplification or up-regulation of PIK3CA, mutation of PIK3CA or PIK3R1,30 or amplification or mutation of Akt131 were shown to activate the oncogenic Akt1 signaling pathway. In biochemical studies, novel protein interactions to the pathway members were commonly reported to efficiently regulate Akt1 kinase activity in cancers.32 For instance, HPV type 16 E7 and Caveolin-1 were demonstrated to independently interact with PP2A, inhibit PP2A binding to Akt1 for disrupting its dephosphorylation, and lead to activation of the Akt1 pathway.27 Similarly, hsp90 formed a complex with Akt1 resulting in maintenance of Akt1 kinase activity by preventing PP2A-mediated Akt1 dephosphorylation.33 In a transgenic model, hydrodynamic injection of constitutive active Akt1 into mouse liver resulted in lipogenesis activation and hepatocarcinogenesis, providing compelling evidence of aberrant Akt1 activation during liver cancer pathogenesis.34
Our finding that eIF3I was a newly discovered Akt1 binding partner raised several interesting questions on the role of overexpression of eIF3I on the function of the Akt1/PP2A axis. First, given that eIF3I could interact with Akt1, we analyzed the possibility whether eIF3I is an Akt1 substrate. The results of an in vitro Akt1 kinase assay demonstrated that GSK-3β, but not eIF3I, was phosphorylated by myr-Akt1 (constitutively active Akt1) (Supporting Fig. 3A). Consistently, the GSK-3β-immunocomplex could be recognized by phospho-Akt1 substrate antibody, whereas no signal was detected in eIF3I-immunoprecipitated complex (Supporting Fig. 3B). These results indicated that eIF3I interacts with Akt1 to constitutively activate its downstream oncogenic signaling, but eIF3I is not an Akt1 substrate. Second, since the interaction between phosphatidylinositol (3,4,5)-triphosphate (PtdIns(3,4,5)P3 or PIP3) with the PH domain of Akt1 has been shown to recruit Akt1 to the plasma membrane where Akt1 is phosphorylated by it upstream kinase PDK1, we therefore determined the subcellular localization of phospho-Akt1 in eIF3I-overexpressing cells. Akt1 protein was mainly localized in cytoplasmic fraction and was also detected in plasma membrane and nuclear fractions (Supporting Fig. 4). Coexpression of Akt1 with eIF3I showed a similar pattern of Akt1 subcellular fraction to that of Akt1 expression. Our results suggest that eIF3I may be one of the cellular factors preventing PP2A dephosphorylation of cytoplasmic phosphor-Akt1 in order to maintain and deliver Akt1 oncogenic signaling. Finally, because eIF3I/Akt1 interaction disrupted the association of PP2A to Akt1 for dephosphorylation, we also examined the possible inhibitory effects of eIF3I to PP2A. We validated the known interaction of PP2A and Akt1 (Fig. 5B) and demonstrated no influence of phosphatase activity under eIF3I overexpression (Fig. 5C). Furthermore, we showed that endogenous PP2A was precipitated in the Akt1-immunocomplex, but not in eIF3I-immunoprecipitates (Supporting Fig. 2). Therefore, our results ruled out the possibility that eIF3I-mediated activation of Akt1 signaling is through the inhibition of PP2A functions.
Although we revealed a new oncogenic mechanism of eIF3I overexpression in HCC and its potential application to other eIF3I-overexpressed cancers, further efforts will be needed to explore potential participation of other oncogenic mechanisms found in other aberrant eIFs. For example, selective translation of “weak” oncogenic mRNAs with potential secondary structures at 5′-UTR might be involving in eIF3I overexpression-mediated tumorigenic effects. Moreover, eIF3I overexpressed in HCC cells might function as a scaffold protein to recruit other Akt1 pathway kinase and effectors to enhance Akt1 kinase activity or as a shuttling protein to change Akt1 subcellular localization for promoting tumor progression.35
Since there is no drug currently available to target oncogenic eIF3I, an improved mechanistic understanding and the finding of concordant expression of eIF3I and phospho-Akt1 in HCC provide opportunities to apply eIF3I as a theranostic biomarker for treating HCC patients with the Akt1-specific inhibitor API-2. Since sorafenib is an FDA-approved multiple kinase inhibitor with therapeutic benefit to late-stage HCC patients, we examined the possible inhibitory effects of sorafenib to the eIF3I-overexpressed HepG2 cells. Our results showed no significant growth difference after sorafenib treatment between eIF3I overexpressing and vector control HepG2 cells (Supporting Fig. 5). Nevertheless, our results open a new possibility to target aberrant mRNA translation control on eIF3I and eIF4E for individual and combination therapies in cancers. Furthermore, since Akt1 has two other closed related isoforms, Akt2 and Akt3, with over 73% identity in entire amino acid sequence and over 88% identity in kinase domain (eIF3I interacting domain), we hypothesize a possibility that Akt2 and Akt3 could potentially associate with eIF3I. Since Akt2 has been reported to be involved in insulin signaling and since Akt3 is mainly expressed in brain and testis,36 we speculate that additional efforts may be warranted to study the role of eIF3I and its modulation of Akt signaling pathway in cardiovascular and neurological conditions.
We thank Dr. Adi Gazdar, MD, professor of pathology at the Hamon Center for Therapeutic Oncology Research, UT-Southwestern Medical Center, Dallas, TX, for careful and critical reading of the article.
Author contributions: Performed experiments: Y.W.W. and S.C.C.; Data analysis and interpretation: Y.W.W., K.T.L., D.L.G., C.F.C., P.H.T., and Y.S.J.; Technical support: K.T.L. and P.H.T.; Drafting of the article and study supervision: Y.W.W. and Y.S.J.


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ON March 28, 2007 a group of policemen stopped Chief Supt Thomas Eluh at Gordon, dragged him out of his car, and in front of his 10-year-old son, punched and kicked him.
They continued even while he was on the ground, pleading for mercy, until he was severely beaten and bleeding, his face cut and swollen and his body bruised.
The policemen carried out this criminal attack, apparently with the full knowledge of their superior, because at that time Eluh was “on the other side” of the divide in the police force.
Although the policemen who attacked him were known, no disciplinary action was taken against them.
Instead, Eluh was transferred to Mt Hagen as the Western Highlands police commander, and then to Bougainville, away from police headquarters.
Eluh sued two senior police officers, suspended Police Commissioner Gari Baki, and the State. If the policemen had any reason for the treatment they dished out to Eluh, they never turned up to defend themselves. Baki also did not turn up to fight the writ lodged in 2008.
This week, a default judgement was awarded by the National Court in favour of Eluh. Damage will be assessed and the policemen and Baki will pay whatever the court assesses to be fitting compensation for what Eluh suffered.
Taxpayers will also pay because the state had been made a defendant.
Justice Bernard Sakora handed down the ruling on Tuesday in Waigani.
The defendants in this case are Insp Sengi Laki, Alfred Reu, then assistant commissioner of police and NCD divisional police commander, Baki and the state.
Elluh was allegedly beaten up in the presence of his 10-year-old son who was in the vehicle at the time of the incident.
He was travelling to Boroko from Bomana Police College.
At Gordon, first defendant Laki, who was in the company of other junior officers, stopped Eluh and attacked him.
Court files stated that Eluh was assaulted “without any good reason or lawful justification in full view of his son and the public, next to the Gordon police station”.
He was then taken to the Waigani police station where he was allegedly further assaulted and detained without any formal arrest or charges for several hours.
Sakora granted the default judgment pursuant to National Court Rules after the defendants failed to file any defence.


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Pamela's First MusicalBook - 1996
Pamela has the best birthday ever when her glamorous Aunt Louise takes her to see a Broadway musical.
Publisher: New York : Hyperion Books for Children, ©1996.
Edition: First edition.
Characteristics: 1 volume (unpaged) :,colour illustrations ;,29 cm.

domain: literature


We design, supply, and install all things related to the structure of any type of building. We do everything from civil, structural, and building envelope construction. Including concrete footings/foundations and structural steel.
We provide installation and maintenance of surface and underground mining equipment ball mills, sag mills, crushers, agitators, screens, conveyors, pumps, winches, filter presses, etc.
We carry out the supply and installation of all process piping focusing mainly on the mining construction including but not limited to; Victaulic, carbon steel threaded and welded, stainless, HDPE, and high-pressure lines for all mining process systems.
As an industry leader in the Structural, Mechanical, and Piping Industry, SSE also offer the services of HVAC design, installation, and Commissioning, electrical and instrumentation as well as commissioning assistance.
We are a leader in providing the highest level of service in the construction industry in North America and Abroad. Our experience in the industry provides our clients with the confidence that we always excel in the demanding market due to SSE’s attention to Health, Safety, and the protection of the environment, Project Management, Scheduling, and QA/QC.
With a highly trained and experienced team, we pride ourselves on providing the highest level of safe, efficient, and quality installations in both the industrial and commercial sectors.
We pride ourselves on our vast experience and the ability to perform all aspects of concrete construction from concrete coatings and foundations to concrete floors, concrete slabs, structural concrete, custom forming, rebar installation, and excavation.


Manish Kharinta is a automotive writer based in the Los Angeles area. He has worked for automotive industry websites TheSmokingClutch.com, CarDekho.com and CarBikeindia.com. His experience ranges from covering auto shows, to car reviews and breaking automotive news. Manish aims to bring forth his unique perspective on automotive design and technological innovations in the automotive industry.
Nov 18, 2018 10:27 AM WST
Tesla has introduced track mode for its Model 3 Performance variant and her's how it works.
Nov 17, 2018 7:00 AM WST
German automaker's CEO broke silence and detailed the company’s plan for upcoming electric vehicles
Nov 14, 2018 6:00 AM WST
What's the reason behind Volkswagens selfless and generous act of kindness?
Nov 12, 2018 10:47 AM WST
The CEO of Tesla, Elon Musk recently tweeted that India is among a list of regions where the company plans to expand its operations.
Nov 10, 2018 6:00 AM WST
Volkswagen made an announcement which seems like an admirable effort to recover from the fallout of the Dieselgate scandal
Nov 05, 2018 12:00 PM WST
Tesla's Shanghai Gigafactory is planning on producing two models during its first phase project.
Nov 01, 2018 11:00 AM WST
Axletech and Thor Trucks have partnered up to develop a heavy-duty electric powertrain system.
Oct 30, 2018 6:00 AM WST
During the recent Paris Motor Show, the current chairman of the board of management for BMW, Harald Krueger confirmed that the company will launch the BMW i4 shortly after the launch of BMW iX3 and iNEXT electric crossover.
Oct 27, 2018 11:00 AM WST
The CEO of Volkswagen group has shown concerns about the fallout that the German Automotive Industry would have to face due to the growing popularity of EVs
Oct 21, 2018 7:00 AM WST
NHTSA breaks silence on Elon Musk's claim and clarifies if Tesla Model 3 is, in fact, the safest mid-size car.


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Hello Piotr., wonderful composition! Great shot! LIKE! Best wishes and kind regards Thomas
very nice photo
Feliz Navidad y prospero año nuevo. ¡¡¡hasta pronto!!!
Merry Christmas and Happy New Year. ¡¡¡See you soon !!!
Nice HDR, L+1
Very nice photo, great work! like 118.
Hi piotr., have a beautiful HDR photographs, very good frame of these stands the empty.
Greetings from Spain. José Mª
Great composition and HDR finish piotr
Beautiful composition and colours ! LIKE
Beautiful composition !
piotr. Very beautiful shot, great clouds! Like124
Best regards from Austria, Erhart
Wonderful sky and the view! LIKE-125! Greetings from Ukraine. Yuri.
Noice work. Like/126! Greetings: Mata Hary
Beautiful view! Like!. Greetings, Renato.
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Photo taken in Golęcin, Poznań, Poland
Misplaced? Suggest new location

domain: artistic


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Alzheimer’s Disease is a devastating neurological condition that can begin with subtle lapses in memory but which may ultimately lead to full-blown dementia. There is no known cure for Alzheimer’s Disease and, according to the Alzheimer’s Association, this disease accounts for somewhere between 60 and 80% of all dementia cases.
Given the potential severity of the condition and the absence of encompassing treatment, identifying and eliminating risk factors is a critical part of the fight against Alzheimer’s. Well, according to a new study published in the British Medical Journal, one risk factor may actually be your medication. If you take benzodiazepines to help with insomnia or anxiety, researchers say you may actually be increasing your risk of developing Alzheimer’s Disease as you age.
Researchers engaged a population of participants who were over the age of 66 and who live independently in the Quebec province. Of those participants, 1,796 had been diagnosed with Alzheimer’s while 7,184 participants served in the control group.
The study evaluated the impact of benzodiazepine use five years after the prescription date. Researchers also measured the difference in impact between those who took higher and lower doses of the medications in question. They ultimately determined that the difference in the likelihood of developing Alzheimer’s is substantial.
Researchers determined that participants who had taken the rough equivalent to a daily dose every day for three to six months were 32% more likely to eventually develop Alzheimer’s than were those without such a prescription. The study also determined that those who took a daily benzodiazepine dose for a period longer than six months were a shocking 84% more likely to develop signs of Alzheimer’s Disease.
Researchers note that there has already been some historic precedent for these findings. Medical professionals have suspected for some time that regular use of this class of drug can reduce brain activity in humans and animals. According to some prior studies, this type of drug binds in the brain in a way that can impede memory, degrade mental function and ultimately contribute to cognitive decline.
For those using popular sleep aid drugs like Lunesta (eszopiclone), Ambien (zopidem) and Sonata (zaleplon), take comfort. These drugs are classified as ‘atypical benzodiazepines’ and were therefore excluded from the study’s findings.
By contrast, researchers found that ‘short-acting anti-anxiety medications’ were seen as being directly correlated to the heightened risk of Alzheimer’s Disease. Among them, the study identifies alprazolam (Xanax), lorazepam (Ativan), oxazepam (Seresta) and diazepam (Valium), and the longer-acting anti-seizure and "hypnotic" drugs frequently used to treat insomnia: clonazepam (Klonopin), flurazepam (Dalmane), midazolam (Versed), nitrazepam (Mogadon), temazepam (Restoril) and triazolam (Halcion).
In most cases, this class of drug is truly only intended for short-term prescription. Guidelines generally suggest that patients should avoid taking benzodiazepines for longer than a three-month duration. For those with a genetic risk or family history of Alzheimer’s Disease, or for those who are generally advanced in age, the study suggests that physicians should carefully evaluate the risks, benefits and alternatives to this form of treatment.


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My daughter has had a lot of ill health recently, and her husband has been wonderfully caring and supportive.
“You have a real treasure there!” I said.
“You didn’t think that when I first knew him,” she said with a grin.
She was quite right. When Icilda and Philip got engaged, I was concerned. They were such different personalities. We have a large and noisy family, and Philip is more reserved. And I had shared my misgivings with my daughter quite bluntly.
I was horrified to realize that the critical things I said so casually 15 years ago had stayed in her memory and could possibly have destroyed a relationship that has proved to be so right and happy. It reminded me how much we need to guard what we say to others. So many of us are quick to point out what we consider to be weaknesses in family, friends, or work colleagues, or to focus on their mistakes rather than their successes. “The tongue is a small part of the body,” says James (3:5), yet the words it shapes can either destroy relationships or bring peace and harmony to a situation in the workplace, the church, or the family.
Perhaps we should make David’s prayer our own as we start each day: “Set a guard over my mouth, Lord; keep watch over the door of my lips” (Ps. 141:3).
Father, please curb my careless speech and put a guard on my tongue today and every day.
A word fitly spoken is like apples of gold in settings of silver. Proverbs 25:11 nkjv
by Marion Stroud


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Improv for the Working Actor
ABOUT THIS CLASS
Are you looking to become a more confident actor and book more work? Improvisation might just be the tool you need. Improvisation not only helps you think on your feet, but it also encourages you to take risks and trust your instincts. In this class, you will learn the basics of improv and how to apply them in auditions and everyday life.
Led by Todd Milliner, Executive Producer of over 500 episodes of television and former instructor at Second City Chicago, this class is perfect for anyone looking to develop their improv skills and use them to their advantage during the audition process.
6 weeks, In-person
Dates: NEW dates coming soon!
Time: 10:00 AM - 12:30 PM
$550.00 for 6 weeks.
Payment plans available.
Email firstname.lastname@example.org to request a refund.
• Use improv techniques to bring something fresh to your auditions and performances.
• Improvise without changing the dialogue using your voice, your body and your attitude.
• Become a better scene partner by practicing rules of agreement.
• Build characters that elevate the material.

domain: hobby


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KUALA LUMPUR: MIC Youth will rebuild the house altar which was demolished by Sepang Municipal Council enforcement officers.
Its chief T. Mohan said the wing would submit an application to the council for the rebuilding as “we want to ensure the altar is rebuilt”.
“We will also provide legal advice to the family to sue the council for compensation,” he said after meeting about 30 Indian-based NGOs here yesterday.
Mohan said the NGOs were unhappy with the council for barging into the house in Taman Seroja, Bandar Baru Salak Tinggi, on Nov 20 and destroying the altar located within the gated compound.
The house owner had earlier received a notice from the council to demolish it on the grounds that the structure had violated council by-laws. A second letter warned she could be fined RM250 per day if she did not tear it down.
State executive councillor Dr Xavier Jeyakumar was reported to have said local councils had the right to take action against illegal structures built inside or outside a house, adding that the Selangor Government could not interfere without a valid reason.
Malaysian Indian Youth council president Raghu Devan Lopez said freedom of religion was one of the tenets of the Rukun Negara but this had not been respected by the council.
“If council officers can go into the compound, then all our houses are not safe,” he said.
Source : http://thestar.com.my/news/story.asp?file=/2012/12/6/nation/12417773&sec=nation

domain: sociology


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Shoppers are being urged to check their melons after a rise in salmonella cases across the UK.
The Food Standards Agency (FSA) has issued precautionary safety advice to customers who purchased whole honeydew, cantaloupe, and galia melons originating from Costa Rica, Honduras, or Brazil bought on or before May 28.
The agency is recommending that consumers check the stickers on the fruit, and dispose of the melon if the country of origin is listed Costa Rica, Honduras, or Brazil.
If customers are not sure or cannot identify the country of origin, the FSA is also advising that the fruit be thrown away.
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“It is important that consumers wash their hands and any surfaces that have been in contact with the melons thoroughly,” Tina Potter from the FSA said.
“This will help avoid the risk of cross contamination and the risk of illness.”
Authorities added that a large number of UK retailers may have stocked the affected melons, which have now been removed from sale.
Doctors say that salmonellosis symptoms ‘typically resolve themselves’, but are urging the public to contact their GP or out of hours service in the first instance.
“Symptoms of salmonellosis typically resolve themselves and include diarrhoea, stomach cramps, nausea, vomiting and fever,” Professor Saheer Gharbia, head of gastrointestinal pathogens unit at Public Health England, said.
“However, symptoms can be more severe and lead to hospitalisation, especially in the very young and those with weakened immune systems. “Anybody with concerns that they have symptoms of salmonellosis should contact their GP or out of hours service.”
Concluding its warning, the FSA said that only the melons listed had been affected by the bug, and were continuing to work with health officials to investigate the issue further.


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It looks like you're new here. If you want to get involved, click one of these buttons!
https://marketwatch.com/story/stock-market-legend-who-called-3-stock-market-bubbles-says-this-one-is-the-real-mccoy-this-is-crazy-stuff-2020-06-17‘My confidence is rising quite rapidly that this is, in fact, becoming the fourth, real McCoy, bubble of my investment career. The great bubbles can go on a long time and inflict a lot of pain but at least I think we know now that we’re in one. And the chutzpah involved in having a bubble at a time of massive economic and financial uncertainty is substantial.’

domain: economics


Send Tips to TIPS@BOSTON.COM
The “Half Baked” star and “Saturday Night Live” alum recently spoke with Boston.com about his show at the Wilbur this weekend, working on a his upcoming heavy metal album, and more.
Beyonce was the reigning queen of Sunday’s MTV Video Music Awards, taking home the Michael Jackson Video Vanguard Award, which was presented by her husband, Jay Z, and daughter, Blue Ivy. Check out this and other scenes from the show. Beyonce Owns the MTV Video Music Awards 2014 MTV VMAs Winners List The Wrap: ‘Dumb and Dumber To’ Star Jim Carrey Sings, Dances and Slips Alongside Jeff Daniels at MTV VMAs (Video) The Wrap: Iggy Azalea, Rita Ora Go Dark With ‘Black Widow’ at MTV VMAs (Video)
Prince is set to release a new album in September.
Phillip Phillips, O.A.R., Magic!, and more will appear at MIX 104.1’s annual free concert at the Hatch Shell in September.
- DEAL: Arthur T. to Buy Market Basket in $1.5 Billion Sale
- Tomatina 2014
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- Sydney's doll hospital: 3 generations of doll repair
- Top 50 scariest horror movies of all time
- Report: Tom Brady 'Was Not Happy' With Logan Mankins Trade
- Deadly landslides hit Japan
- Roger Federer’s Ridiculous Between-the-Legs Shot Impresses Michael Jordan
- Top 30 zombie movies of all time
- Zara Apologizes for Shirts That Look a Whole Lot Like Concentration Camp Uniforms


About Alfonso Flores
Get to know Alfonso Flores
Maestro Flores is a person with more than 40 years of experience
in music education as a piano and trombone teacher, he is a
conductor with a specialty in concert bands and symphonic bands
in both the classical and modern areas.
His musical studies were carried out in his native country of
Honduras and his higher studies at Los Angeles City College and
Cal State L.A University, California.
As a piano teacher he has a lot of experience with children and
young people as well as having a lot of knowledge in the area of
Worship for young people who want to serve in the music
ministries of their churches.
Maestro Flores is also a Music Producer, Arranger and Audio
Engineer with work done in Mexico, Spain and the USA.
Now living with his family in Pearland, Texas, he feels very
honored to be part of the Music and Arts family.


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Rakesh Holla is based in the temple town of Udupi in South India.
He and his friends are always on the move during weekends exploring little gems of Western Ghats. When they have more time they venture out to other lovely places in the country. He documents his exploits in the nice blog which he calls as "Voice of Greenery".
Rakesh was exploring the unknown islands off Udupi coast last month before the monsoons set in. These islands look lovely and serene. Good part of the story is that they continue to be away from the glare of mass tourism. Hope they remain likewise for some more days to come.
Till then, enjoy the trip to "Light House Island" and "Kotepare Islands" here
If you want to know more about Udupi or plan to travel there please look at the following posts in this blog.
Driving Holidays from Bangalore - Karavali and Koffee Kombo
Karavali Vistas II - Udupi, Mangalore and Bekal

domain: travel


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Oklahoma State Filing
Select your State for 1099 Reporting Requirements
Oklahoma 1099 State Filing Requirements
- Form 1099 (1099-NEC, 1099-MISC, 1099-INT, 1099-DIV, 1099-R, 1099-B, 1099-G, 1099-K, 1099-PATR)
Deadline to file Form 1099-NEC is
January 31, 2023
Deadline to File Form 1099 For Form 1099-MISC, 1099-INT, 1099-DIV, 1099-R, 1099-B, 1099-G, 1099-K, 1099-PATR is March 31, 2023
TaxBandits supports the filing of Form 1099 with both the Federal and State of Oklahoma.
Q. Does Oklahoma mandate 1099 filing?
A. Yes, the Oklahoma Tax Commission mandates the filing of the 1099 Forms even if there is no state tax withholding.
Q. What types of 1099 forms does Oklahoma require?
A. Oklahoma requires the filing of the following 1099 forms.
Q. Does Oklahoma have any additional requirements when you file 1099 forms?
A. No. The state of Oklahoma doesn’t require any additional forms to file along with Form 1099.
Q. What is the due date to file 1099 with Oklahoma?
A. The due date for Form 1099-NEC is January 31 and other 1099 Forms is March 31
Q. What are the requirements to file 1099 electronically with Oklahoma?
A. The State of Oklahoma mandates filing electronically if you are submitting 5 or more 1099s.
Q. Where do I mail Oklahoma 1099 forms?
A. Mail your Form 1099s to the following address.
Get started with TaxBandits today and stay compliant with the State of Oklahoma! Start Filing Now

domain: geography


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The SLO Chamber celebrates new member, MZR Fitness, with a ribbon cutting ceremony.
MZR Fitness was created to help improve the overall health and quality of life for their clients and their families with their unmatched expertise, unique workouts, constant motivation, and extreme accountability at MZR’s truly one of a kind fitness facility. Through the variety of services, MZR Fitness promises to deliver to you an amazing fitness experience to help you achieve fitness success like never before; according to their website.
MZR Fitness recently moved to 3536 S. Higuera Street in between Breaking Bread and Coastal Peaks Coffee to a building that allowed operations to triple in size allowing Personal Trainer and Owner, Mike Z. Robinson to reach and change the lives of even more clients.
For more information, visit mzrfitness.com or visit them in person at 3536 South Higuera St. Suite 200 in San Luis Obispo.


Sony introduces Xperia Tablet S along with Xperia T, Xperia V and Xperia JAlex Wagner - Editorial Director of News and Content
As expected, Sony took to the stage in Berlin today to kick off its IFA 2012 press conference, and the company introduced a handful of new products at the event. First up is the Xperia Tablet S, which we saw leak out a couple of times in the past month. The Xperia Tablet S packs a quad-core Tegra 3 processor buried inside its body, and interested customers will have the option of picking one up with either 16GB, 32GB or 64GB of built-in storage. In case that's not enough storage, the Xperia Tablet S also features a full-sized SD card slot. Other specs include a 9.4-inch 1280x800 IPS display, 6,000mAh battery, a splash-proof body, infrared support and Android 4.0.3.
Sony says that the Xperia Tablet S will be available starting September 7 (pre-orders start today) with pricing set at $399 for the 16GB model, $499 for the 32GB version and $599 for the 64GB flavor. The Xperia Tablet S will also be compatible with a number of accessories, including cover/keyboard combo for $99.99, docking stand for $99.99, charging cradle for $39.99 and a dock speaker that'll launch in November for $129.99.
Along with the Xperia Tablet S, Sony took the wraps off of a trio of new Xperia-branded smartphones: the Xperia T, Xperia V and Xperia J. There's quite a few spec details to run through with all three devices, so we're going to present them in an easy-to-digest list:
- Sony Xperia T: 4.55-inch 1280x720 Reality Display, 1.5GHz dual-core MSM8260-A processor, 13-megapixel rear camera, front-facing shooter, 1GB RAM, up to 16GB storage, microSD slot, HSPA+ connectivity, 1,850mAh battery and Android 4.0 Ice Cream Sandwich. Will be available in black, silver and white. Sony also notes that the Xperia T will be branded as the Xperia TX in some markets.
- Sony Xperia V: 4.3-inch 1280x720 Reality Display, 1.5GHz dual-core MSM8960 processor, 13-megapixel rear camera, VGA front-facing camera, 1GB RAM, 8GB storage, microSD slot, HSPA+ and LTE support, 1,750mAh battery and Android 4.0. Will be available in black, pink and white.
- Sony Xperia J: 4-inch 854x480 display, 1GHz MSM7227A processor, 5-megapixel rear camera, VGA front shooter, 512MB RAM, 4GB internal storage, microSD slot, HSPA connectivity, 1,750mAh battery and Android 4.0. Will be available in gold, pink and white.


150 mm Systems
The MPS150 is an easy to use, yet highly-precise manual probe platform for wafers and substrates up to 150 mm. Pre-configured application-focused probing solutions are available with everything you need to achieve accurate measurement results in the shortest time, with maximum confidence. The MPS150 is the industry’s probe platform of choice.
The broad use of power semiconductors has created a pressing need to characterize power devices quickly and efficiently. Cascade offers on-wafer power device characterization systems to reduce time-to-market for new power devices and to keep up with production.


The installation of the first wind turbine fins at the West Bakr wind farm project located 30 km north-west of the town of Ras el Ghareb in the Gulf of Suez, Egypt, has commenced approximately eight months after the ground-breaking ceremony for the project. This operation was launched on October 21st, 2020 by Siemens Gamesa Renewable Energy SA formerly known as Gamesa Corporación Tecnológica S.A. and Grupo Auxiliar Metalúrgico S.A. The latter is a Spanish-German wind engineering company that manufactures wind turbines and provides onshore and offshore wind services.
Apart from manufacturing and delivering a total of up to 96 SG 2.6-114 wind turbine units for the West Bakr wind farm project, Siemens Gamesa Renewable Energy SA is also responsible for the construction of the wind farm under an engineering, procurement, and construction (EPC) contract signed with the project developer, Lekela Power.
Once online expectedly sometime next year, the 250 MW West Bakr will increase the North African country wind power capacity by 18% and generate enough power to meet the consumption needs of over 350,000 households.
Financing for the project
The West Bakr wind project is entirely financed by Lekela Power to the tune of about US$ 252M. The Africa-focused renewable energy company raised the funds in form of loans from several investors including the International Finance Corporation (IFC), the European Bank for Reconstruction and Development (EBRD) and the US International Development Finance Corporation (DFC), the former Overseas Private Investment Corporation (OPIC), which merged in December 2019 with the Development Credit Authority (DCA).
The loans will be repaid through the sale of electricity generated by the plant within the framework of the 20-year Power Purchase Agreement (PPA) signed by Lekela power with the Egyptian public power transmission company (EETC).


Tulsa Police Searching For Stolen Unmarked 2020 black Ford Escape patrol car that has a paper tag.
A YOUNG bride who was widowed on her wedding day when her groom was shot dead by two of her guests cried "how will I live without you?".
By Nika Shakhnazarova / newsbreak Though she's enjoyed a glittering career on stage, Tina Turner 's personal life has been plagued by ill health. The What's Love...
Popeyes has recently released their new Cajun Flounder Sandwich, featuring a crispy flounder fish fillet that is topped in a panko breading (with Cajun spices!) as well as some Pickles and Tartar sauce. How good is this fish sandwich
Nearly three years after the body of 20-year-old Mollie Tibbetts was found in a cornfield, prosecutors delivered opening statements in an Iowa courtroom Wednesday accusing a farmworker of following her on a run, fatally stabbing her, putting her in his vehicle's trunk and then hiding her body.
A hybrid animal that’s a mix of polar bear and grizzly bear has been created in the wake of the ongoing global warming crisis.
Comedian Paul Mooney has passed away at the age of 79, it was revealed on Wednesday.
The Lee family's handling of the hefty inheritance tax bill - one of the largest ever in both Korea and globally - had been closely watched as it could have resulted in the dilution of the family's controlling stake in Samsung.
A Los Angeles dentist has been charged with sexually abusing nine women while they were undergoing procedures.
Tina Strader, 46, of Venice, was found brutally slain in a hotel closet
One person was killed in a crash outside a senior rehabilitation center in Bucks County, Pennsylvania.
Like many artists, Matthew Willey had longed to meet his muse. He had no idea she would fly in through his apartment window. The bee that buzzed into his room in late spring, 2008 so entranced the New York-based muralist that he embarked on a mission to highlight growing threats to pollinators by hand-painting 50,000 individual bees on buildings around the world.
The search continued Friday for two tubers on the Dan River who were reported missing Thursday afternoon. Three bodies were recovered from the Dan River Thursday evening in North Carolina, but two remain missing.
A terrifying new tarantula-like spider species that uses a trapdoor to hunt prey has been discovered - and it lives for decades.
A Chinese zoo is under scrutiny for keeping the escape of three leopards from a big cat enclosure under wraps.


Just in time for the Holidays, Pepsi has decided to release a new apple pie flavored Pepsi product. But there's a catch, you can't buy one in stores!
You can however win one!
Pepsi has created a fun Twitter contest to give away bottles of their latest apple pie product to those who are baking challenged.
All you have to do is share a pic of your baking fails with #PepsiApplePieChallenge to get Pepsi Apple Pie!
Pretty easy right?
So next time you're thinking of hitting the kitchen take your phone and if it goes wrong, snap a pic and use the hashtag above!
Photo Credit: Getty


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The full line-up for this year’s Radio 1 Big Weekend has been revealed, and lo and behold, it marks the first we’ve seen of Lorde to the UK for blimmin’ ages!
Her appearance at the event in Hull in May will be her first performance in the country for over two years, and if her set at Coachella is anything to go by then expect a good dash of tunes from ‘Melodrama’ as well as hits from her ace debut album ‘Pure Heroine.’ Bet she’ll bring some ‘Homemade Dynamite’ to the occasion…
She’s not the only addition to the Hull bash either. Kasabian, Biffy Clyro and Bastille have all been added to the line-up, with Royal Blood, Two Door Cinema Club and Rita Ora also heading for the Capital of Culture. Katy Perry, Kings of Leon, Little Mix and Stormzy were among the acts already confirmed to play at Burton Constable Hall. Crikey!
Radio 1’s Big Weekend gets underway in Hull between 27th-28th May. Find out more about the line-up here and watch Lorde’s video for ‘Green Light’ (which, let’s face it, we’ll all be singing along to) below.


Romelu Lukaku reveals emotions in the direction of Chelsea throughout Q&A
Romelu Lukaku posted Q&A on Twitter tonight and there’s a lot to discover if you’re a Chelsea supporter.
Lukaku signed for Chelsea when he was a teenager who had impressed back home in Belgium. Unfortunately Didier Drogba, Nicolas Anelka and Fernando Torres blocked his way into the starting XI.
After on loan at West Brom and Everton, Lukaku decided to leave Stamford Bridge permanently to pursue his career and signed a £ 28m deal for the Toffees, according to the BBC.
Lukaku has grown into one of the best strikers in the world, much to the horror of Chelsea fans no doubt, but could he return to the bridge one day? The door appears to have been left open.
When Lukaku was posting Q&A on Twitter tonight, he found that he has “nothing but love” for the blues.
Nothing but love. They gave me the opportunity to get into the @premierleague as a kid. You can’t have everything in life and I’m cool with it. I am glad that this experience brought me to where I am today https://t.co/yzIpsKzfiF
– R. Lukaku Bolingoli9 (@ RomeluLukaku9) February 23, 2021
More stories / Latest news
Chelsea could find themselves in the market for a striker this summer. Olivier Giroud’s contract is expiring and Tammy Abraham shows little sign that he will develop into a world-class front man.
Could Lukaku be the answer to Thomas Tuchel’s problems in front of goal?


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In 2024 Lefika La Phodiso celebrates its Pearl anniversary. 30 years of recovery and growth. 30 years of art and counselling. A safe space for adults and children who are otherwise ill-equipped to process the trauma and hardships of life. A guiding light to those who would take the skills gained at Lefika La Phodiso and share their knowledge and abilities with their own communities. A haven. A home.
Notably corresponding with the 30-year anniversary of democracy in South Africa, this also highlights the reality that although there have been major advancements in access to education, there are still so many obstacles standing in the way of equal and indiscriminate access for all.
Lefika La Phodiso was brought into being in 1994 by Hayley Berman, an accomplished art psychotherapist who saw a unique opportunity to bring the joy and healing of art and creative self-expression to Gauteng. Since then, the organisation has grown and developed into an educational institution that embodies healing, safety, transformation, creativity, expression and belonging. The vision? To provide safe spaces in which creativity and containment nourish emotional development and strengthen relationships.
In 2023 Lefika La Phodiso was awarded as a beneficiary of the Presidential Employment Stimulus Programme 4 (PESP 4) and has consequently embarked on a journey telling the story of the organisation, its contributors, its legacy, and its “family”. These pages hold the stories of some of the lives that the team and contributors of Lefika La Phodiso have shaped over the last 30 years. The project serves to showcase the important work that Lefika La Phodiso has done and continues to do in its feeder communities.
Through the use of art-based counselling and training, Lefika La Phodiso has the ability to transcend cultural, linguistic and educational boundaries. The importance of mental health awareness, community support and education is at the heart of the work. In 1994 and subsequently, in the newly democratic South Africa, the need for education and mental health support has been immense. Among the many challenges faced in bringing the organisation along this 30-year journey, the consistent and ever-present need for funding and financial support continues to be the largest obstacle. This publication and the supplementary activity books, proposed exhibitions and by-products serve as a beacon of encouragement to potential funders and supporters, with the aim of expanding this essential outreach.


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Gossamer 10-karat gold diamond earrings
The unique shapes in Hirotaka's collections are inspired by natural objects seen in the ocean or rainforest. Handmade in Japan from 10-karat gold, these earrings are encrusted with glistening diamonds and hook effortlessly into your lobe. Stack them with the green garnet version.
This item's measurements are:
- Drop: 2cm / 0.8in
- Width: 1cm / 0.5in
- Round brilliant-cut SI2 diamonds, total weight: 0.14-carats
- Slips on
- NET-A-PORTER is a certified member of the Responsible Jewellery Council
- Made in Japan
Returns or Exchanges
Try your purchase on in the comfort of your own home and let us know straightaway if you’d like a different size or a refund and we’ll collect from your home, work or an alternative address.


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Bonn/Region In Bonn and the region, the weather remains uncomfortable this week. This morning, it could be all white and slippery again. The city forester's office is still busy with the removal of the damage from last weekend.
After the snow which "Jussuf" brought caused numerous firefighting operations in Bonn and the region last weekend, the German Weather Service (DWD) warns of new snowfalls. On Tuesday afternoon, the DWD issued slippery and snow warnings for the Rhine-Sieg district and the districts of Neuwied and Ahrweiler. Accordingly, there may be a small amount of fresh snow and slippery conditions on Wednesday morning.
By the end of Thursday it will be temporarily milder
While there was light precipitation on Monday as well as on Tuesday, it is supposed to become wintry again on Wednesday. After that, it will become noticeably milder. Temperatures will rise from just above zero to as low as five degrees on Wednesday and may even climb into the double-digit range up to eleven degrees during the middle hours of Thursday. Instead of a white splendor of snow, Bonn residents can expect almost entirely overcast skies at these temperatures, with the promise of rain and gusty winds throughout Wednesday and much of Thursday.
Only on Friday should the sky clear up with temperatures around five degrees. However, it will remain windy and locally there may be repeated small rain showers.
City of Bonn continues to warn against walks in the forest
After the snowfall over the weekend, the city forestry service is expected to be busy with cleanup work in the city forest until the end of the week. Affected are mainly forest areas on the Venusberg, in Godesberg and in Ückesdorf and Röttgen. The city forester's office is temporarily closing off dangerous forest paths with barrier tape until the damage has been repaired.
(Original text: ga, Translation: Mareike Graepel)


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Mint light green pure chanderi and crinkled cotton kurta dress with silver highlight on bottom flare fabric. The outfit has silver gota work on sleeves and bottom flare, has lining inside and 2 side pockets. Wear it as a dress or team it with a bottom for a suit look. Dry Clean only
NOTE: Delivery of the product will take 2-3 weeks since this is a made-to-order piece.
Measurements: Please refer to the sizing below before placing your order, and select the desired size from variants.

domain: design


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Independent label specialized in producing high-quality recordings devoted to rare or unusual repertoire of classical music.
INEDITA is an independent label specialized in producing high-quality recordings devoted to rare or unusual repertoire of classical music.
More than two hundred are the compositions, rare or completely unknown, which INEDITA has recovered during his decades of work dedicated to research and record production. Many of these works were composed by authors as unknown as deserving of being exhibited to the public of enthusiasts. Others are rare or unpublished works of well known authors, brought to light through patient and painstaking research, starting from the study of the sources, stored in archives and libraries, to arrive to the creation of the disc; only after a careful and rigorous musicological study which can last, in some cases, for whole years.
Therefore, every production of INEDITA takes on the outlines of a real event, often able to solicit musicological debate and add new rawlplugs to the knowledge of musicians such as Lao Silesu, Giovanni Toja, Domenico Sigismondi, Giuseppe Rabboni, Giacomo Monzino, and others; today finally returned to the musicological historiography and collective enjoyment through the CD.
INEDITA has also promoted researches in music considered rare or lost, regarding anything but unknown authors. These include the discovery of an unpublished and unknown Mass composed by Alessandro Scarlatti and the production of the first recording of the Humoreske for violin and orchestra by Ottorino Respighi.
The Beethoven Rarities series, now in its seventh volume, offers the most exclusive collection of rarities and world premiere recordings by Beethoven; including the world premiere of the Macbeth Overture - performed for the first time in Washington in 2001, the second in Britain in 2002 and the third in Sassari (Italy) in 2003 (the last one recorded on our CD) -, the new critical edition of the early Concerto for piano and orchestra WoO 4, and the first movement of an unfinished concerto for piano and orchestra of 1815 (Hess 15), written six years after the Emperor.
The productions of INEDITA have been reviewed in newspapers and journals all over the world, and have won several international awards.
AdrianoOrchestral Works Concertino for piano, percussion and stringsSylvia Capova-Vizvary (piano)Bratislava Symphony Orchestra, Adriano (conductor) Obscure SarabandMarek Vrabel (organ) Cryptic Sketches, for Brass QuintetSlovak Brass Quintet Concertino, for Celesta and StringsTomas Nemec (celesta)Bratislava Symphony Orchestra, Adriano (conductor)
Ancient Airs and Dances for the Lute (Guitar transcription) by: Molinaro, Galilei, Barberis, Negri, Besard, Roncalli, Gianoncelli and others. Paolo Pilia (guitar) Ottorino Respighi Ancient Airs and Dances for Lute (II Suite) Ancient Airs and Dances for Lute (I Suite) St. Petersburg Symphony OrchestraRoberto Diem Tigani (conductor)
Ludwig van Beethoven Piano Concerto in E flat major, WoO 4Romance cantabile, Hess 13, for Flute, Bassoon and PianoRomances Nos. 1 & 2, for Violin and Orchestra12 Contredanses, WoO 14 Maurizio Bignardelli (flute)Alessandro Mura (bassoon)Maurizio Paciariello (piano)Marco Rogliano (violin) Sassari Symphony OrchestraRoberto Diem Tigani (conductor)
Ludwig van BeethovenMacbeth Overture (World Premiere Recording)Rondo in B flat major WoO6 for Piano and OrchestraPiano Concerto ("No. 6") in D major op. 61a Maurizio Paciariello, piano Sassari Symphomy OrchestraRoberto Diem Tigani, conductor
Ludwig van BeethovenPiano Trio in D Major, Kinsky/Halm Anhang 3Piano Trio No. 8 in E flat major, WoO 38Piano Trio No. 9 in B flat major, WoO 39Piano Trio No. 4 in B flat major, Op. 11 "Gassenhauer"Allegretto in E flat major, Hess 48 Frank Bridge TrioRoberto Mazzola (violin)Giulio Glavina (cello)Mariangela Marcone (piano)
Giulio Briccialdi (1818-1881) Fantasy Op. 39 on Verdi's AttilaMaurizio Bigardelli (flute) Duo Concertante, Op. 33Carlo Tamponi (flute) Fantasy on the air 'Ah! perchè non posso odiarti' from Bellini's La SonnambulaSalvatore Vella (flute) Concerto for Flute and Piano, Op. 19Andrea Manco (flute) Gian Rosario Presutti (piano)


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The dog (Canis lupus familiaris) is a domestic subspecies of the wolf, a mammal of the Canidae family of the order Carnivora. The term encompasses both feral and pet varieties and is also sometimes used to describe wild canids of other subspecies or species. The domestic dog has been (and continues to be) one of the most widely-kept working and companion animals in human history, as well as being a food source in some cultures.
The domestic dog's health is possibly one of the best-studied areas in veterinary medicine, since the dog has had such a long and close relationship with humans. Infectious diseases are prevalent in dogs and are important not just from a veterinary standpoint but also because of the risk to public health.
Our directory - ReadyDog.com is an online dog directory providing links to dog tag, dog care, dog apparel, dog's product, dogs poop scoopers, dogs bedding, veterinary services, puppies, dog breeders worldwide, crystal dog collars, luxury dog products, paints portraits of dogs, dog health, dog training, dog pictures, dog food, dog rescue, dogs stuff and more.
If you are interested in knowing more about us and our services, click here to contact us.

domain: pet


Our high-density rigid spray foams capture the details of the original mold, while high closed cell content provides excellent buoyancy, strength, and insulation properties. Conforming to irregular shapes with excellent adhesion is critical for custom formulated success, and our specialty spray foams can provide a trustworthy solution.
For example, our polyurea liners have the ability to protect concrete, steel, wood, and other composites by creating a seamless and sturdy membrane that is highly chemical-resistant. These coatings can be used in a variety of ways, and be custom-fit to your design requirements. Additional applications include secondary containment, corrosion protection, and decorative scenery.


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Yesterday, executives from the Mohegan Sun casino in Uncasville, Conn., shared details on a second hotel being added to the flagship property. When it opens in the fall of 2016, the seven-story, 400-room Earth Hotel is expected to add 500,000 room nights to the resort per year.
At a press conference announcing the $120 million development, Kevin “Red Eagle” Brown, chairman of the Mohegan Tribe, said that the Mohegan Tribal Nation has invested well over a billion dollars that has made the tourism industry sit up and take notice. We take very seriously our role in Connecticut’s tourism industry and economic welfare.”
According to the Hartford Courant, the announcement came two days after the Northeastern Gaming Research Project painted a "gloomy outlook" for Mohegan Sun and the other notable Connecticut casino, Foxwoods.
The report found that residents in Massachusetts spent $400 million less at the Connecticut casinos compared with a decade ago, while residents in Rhode Island spent $200 million less. Half of the decline was tied to the recession, but the rest was being spent in other states.
The article also notes that Mohegan may join with Foxwoods to operate a satellite casino, possibly in the Hartford area, to compete with the MGM casino now in the early stages of construction in Springfield. Approval from the Connecticut legislature would be required.
Beyond Connecticut, Massachusetts has plans to develop three casinos, one of which is slated for Springfield. Rhode Island is investing in improvements in its aging gaming complexes, and more casinos may soon open in New York.
Kohn Pederson Fox (KPF) out of New York is the architectural firm of record for the Mohegan development. KPF was also the master architect for Mohegan Sun’s existing 1,200-room Sky Hotel which opened in 2002. A/Z Corporation, with headquarters locally in North Stonington, Connecticut, has been hired as general contractor for the project following various completed projects at Mohegan Sun.


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If you’ve spent time creating with resin, you may have wondered, can epoxy resin be used on glass? In a short answer, yes. But if you’ve learned anything around here already (besides how to make conversation heart jewelry), you know there’s always more to the story.
Epoxy resin is a strong glue.
Besides being a fun medium to create with, epoxy resin is also an excellent glue. You can use it to bond jewelry findings to your resin charms. It also glues to glass very well, provided the surface is clean. That means if a glass surface is free of dirt and oil, resin will stick to it with no trouble.
This ability to stick to almost anything is why you can’t use a glass baking dish as a resin mold. The resin clings to it, and the glass isn’t flexible enough to release the resin, even when you use a resin mold release.
Should you use epoxy resin on glass?
So here is where things get a little complicated. Just because glass and resin bond easily doesn’t mean bringing them together is a good idea.
Despite joining your resin and glass to create one project, it will expand and contract at different rates. When a resin and glass combo heats up and cools down, it acts as two separate items, not the one design you created.
Resin and glass used together and then kept out of direct sunlight and away from heat generally isn’t a problem. But, add weather elements to it, and the expansion and contraction cause the glass or the resin to crack. For example, a resin and glass window displayed in direct sunlight will break when there is a noticeable temperature change. Like going from hot to cold or vice versa.
Now that you know epoxy resin can be used on glass, how do you do it?
You’ll use your resin as a glue. Apply a bit of mixed epoxy to each piece, then press together. Make sure you wipe off any excess before letting the resin cure. You won’t be able to get it off once dry.
What if you want to create something that looks like window panes of glass?
Instead of pouring the resin over the glass, create the window panes with resin by using a resin mold. Then, glue the resin window panes into the frame, using epoxy as glue. If you want to pour resin over window panes, display your resin art where you can protect it from temperature extremes.
⭐ BONUS: There are a few other details to know. You can learn them in this beach picture display window tutorial.
Ready to get started with resin but unsure where to start?
Tried it already but frustrated with your results?
I get it. I was there once too. It’s why I condensed my 17 years of resin knowledge into the ebook, Resin Fundamentals. It’s all the things I wish someone had told me about resin when I got started. Avoid the same mistakes I made. Buy the resin PDF book and get a download link by email in minutes.
Unpublished Blog Posts of Resin Obsession, LLC © 2023 Resin Obsession, LLC


SIR: As 2015 general elections gather momentum, politicians have begun wide consultations on their ambitions while some political parties and various interest groups have at the same time commenced endorsement of their preferred candidates. States, zones, tribes and socio-cultural/religious organisation are not left out in this endorsement galore.
With the array of aspirants to various political offices, the choice for the best might be an arduous one. However, as the electorates who hold the ace to political offices, we must be wise in choice. The forthcoming general elections will be a litmus test of our electoral sagacity. Nigerians should look out for aspirants whose programmes for election reflect the yearnings of the people in the areas of poverty alleviation, quality education, health care and agriculture. Time for politics of stomach infrastructure and empty promises should be over in 2015. Nigerians had been led by their noses for a long time thus anyone who seeks their mandate on any elective post or political platform come 2015 should be the one ready to honour a valid social contract.
Without recourse to party affiliations, they should vote for that man whose presence in government will afford greater opportunities for rapid development.
Sunday Onyemaechi Eze


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The Sakura Snoop is impregnated with natural pheromones for added appeal to predators and the 150mm size comes rigged with internal glass rattles.
A unique rib design gives the lure an incredible action in the water which is achieved by frequent rod jerks and twitching. The Snoop allows the angler the flexibility to fish either weedless close to the surface using texposer hooks or deeper, bumped along the seabed using a jig head.
- Product Code: SKASB
- Availability: In Stock


IQI Weekly Seminar
Abstract: We consider quantum Gibbs states with Hamiltonians on arbitrary graphs (i.e., including infinite dimensional systems or long-range interacting systems). The simulation of such states is known to be usually NP-hard to due to exponentially increasing parameters. However, when we restrict ourselves to high-temperature regime, various problems become significantly simple. In this regime, any kinds of non-local structures are believed to disappear, and it is a crucial problem how to characterize the absence of non-local structures in the quantum Gibbs state. In the present talk, we prove the following fundamental properties above a certain threshold temperature: i) existence of the fully-polynomial-time-approximation scheme to simulate thermodynamic properties, ii) quantum approximate Markov chain, iii) Ensemble equivalence between the canonical and the micro-canonical distributions for long-range interacting systems.


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With spring just around the corner, and summer on the horizon I’m craving all the fresh, colorfully, fruity things. Key lime pie isn’t really fruity (obviously) but it’s vibrant with it’s cool, creamy, lime-citrus-y vibe it’s got going on.
I love a smooth, creamy pie. And I’ve always felt that key lime pie is the type of dessert that once you bit into a slice of it, it’s practically gone. It’s something about the sweet, slightly tart flavor of the creamy filling and the crumbly texture of a graham cracker crust that just makes this pie truly irresistible.
I don’t know if you know this about me, but I’m all about a good graham cracker or cookie crust. I have a firm belief that it can make or break the whole thing. When it comes to a graham cracker crust I love to add a little ground cinnamon to it. It really gives it a little something extra. A little hint of cinnamon up against the sweet, tartness of this key lime pie filling is amazing. I recommend you try it with any recipe calling for a graham cracker crust.
For the Crust:
- 1 and 1/2 cup crushed graham cracker crumbs
- 1/4 cup sugar
- 1 teaspoon ground cinnamon
- 6 tablespoons unsalted butter
For the Filling:
- 4 large egg yolks
- 1 14 oz can sweetened condensed milk
- zest of 1 lime
- 1/2 cup key lime juice
- *Whipped Cream and thin lime slices for garnish
- Preheat oven to 350 degrees. Lightly spray a 9 inch pie dish with non stick cooking spray. Set aside.
- Combine graham cracker crumbs, sugar, cinnamon and melted butter into a bowl and mix together until the crumbs are evenly coated with butter. Pour the crust mixture into the pie dish and use your hands (or the back of a measuring cup) to firmly pack the crumbs into the bottom of the pie dish, forming a crust. Bake the crust for 8-10 minutes.
- Make the pie filling: Add the egg yolks into a large mixing bowl. Using a handheld electric mixer, beat the eggs on medium high speed for 5 to 7 minutes. Do not skip on time, you want the egg yolks to be really thick, fluffy and pale in color. Reduce the speed of the mixer to low and slowly add in the sweetened condensed milk, continue mixing until combined, scraping down the sides of the bowl as needed. Add in the lime zest and the key lime juice and continue mixing until everything is combined. Pour the batter into the prepared crust and smooth out the filling with a spoon or spatula. Bake pie for 15 to 20 minutes.
- Allow the pie to cool to room temperature and then let it chill in the refrigerator for at least 4 to 6 hours or up to overnight. Once the pie has chilled you can top if with whipped cream and use the left over lime (that we used for the zest) and slice it into thin slices to garnish the top of the pie. Cut into slices and serve.

domain: food


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Happy New Year! I hope everyone is starting out 2020 with all the proper intentions. I literally woke up today in a mental state that had me slipping into a damn depression. And let’s be frank, no one has time for that in 2020!
So to alter my mood we’re talking about my depression, how I deal with it plus Nick Gordon, Rihanna, Kevin Hart, and Megan Thee Stallion with Beyonce.

domain: psychology


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(Corn Hill, Rochester, New York – December 7) “Memories of a New Year’s Day” will be performed in Corn Hill on Thursday December 29 at 7:00 p.m. This walking tour, beginning at Ralph Avery Mall at the foot of Frederick Douglass Street between Plymouth Avenue and Adams Street, uses songs, readings and stories about the old Third Ward, as the neighborhood was known before it acquired the Corn Hill name.
Historical Third Ward figures represented during the hour-long presentation include Katherine Rochester Montgomery, Virginia Jeffrey Smith, Charles Mulford Robinson, Samuel Hopkins Adams, and a curious person known only as “A Bachelor.” Corn Hill historian Jim DeVinney serves as narrator.
The free tour, which premiered last year, is inspired by a chapter in Adams’ book Grandfather Stories. A popular journalist and author during the first half of the 19th Century, Adams’ father was pastor of the Plymouth Congregational Church that once stood at the corner of Plymouth and Troup Street. Grandfather had been an official in the early days of the Erie Canal.
In the story, Adams describes how he and his cousins visited a series of open houses that took place on New Year’s Day in the famous Ruffled Shirt District, especially at homes with daughters of a marketable age. The boys were too young to be interested in anyone’s daughters but they were eager to sample the wonderful food served on this occasion. Before the day is done, they experience both adventure and misadventure.
The tour provides stories that are humorous, nostalgic and, in one case tragic, as it defines the rise and fall of the Third Ward and its rebirth as Corn Hill. Performers include Ira Srole, Sally J. Millick, Katrina Grbesic, Kevin Petrichick and Shawn Gray.
James A. DeVinney has been Corn Hill’s historian for the past two years. In that capacity, he leads tours through the historic neighborhood and writes a monthly column for the Corn Hill Gazette. Before he retired, he was a TV producer and filmmaker, earning four television Emmys, four Peabodys, an Academy Award nomination, and numerous journalism awards.
Michael McCarthy will be launching his new book, The Children of Michigan Street on Wednesday, December 14, 2016 from 4:00 p.m. to 7:00 p.m. in the Wilson Formal Lounge on the St. John Fisher College campus. The public is invited to this meet and greet, book-signing event.
This book is Mike’s third historical novel about a first generation Irish-American growing up in the Western New York town of Lockport in the 1840’s and 50’s. While his Irish born parents are assimilating into their New World, their eldest son is watching his nation of birth move toward civil war. This compelling story of loyalty, values, and the spirit of adventure clash with the realities of division, contempt and forgiveness.
I hope to see you there!
Michael E. McCarthy
From Cork to the New World: A Journey for Survival (2009)
The Flight of the Wretched: A Journey to the New World (2011)


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I was referred to Jesse from my chiropractor after he reccomended I give him a call a couple of times. I was nervous to call an attorney, but so glad I did! Jesse Bablove handled everything while also ensuring I received any aftercare I needed to recover from the accident! Recognize your value and worth and give them a call. Thank you guys for going above and beyond!Melanie Tydingco
Mr. Bablove managed to help me receive the maximum payout possible from my auto accident. He was very responsive and made sure I got every bit of medical attention I needed. He’s a good guy, I would highly recommend him.Jeff Renfro
Upon being referred to the guys at Kohan & Bablove Injury Attorneys, I spoke with Jesse about my case, and from the get go he was super hands on and a genuine guy who treats you like family and cares for the well being of his clients. I would definitely recommend Jesse and his team to one of my friends or family members!jared batson
If you were hit by a car while riding your bicycle, you almost certainly suffered serious injuries and now have a number of damages and losses to deal with. Find out if you can get compensated by working with a Riverside bicycle accident lawyer.
If you were injured in a bike wreck that was caused by someone else, you have the right to file a personal injury lawsuit. However, these cases can be complicated, and it is critical to prove negligence, making it important to work with a Riverside bicycle accident lawyer from Kohan & Bablove, Injury Attorneys.
While the driver of the car that hit you is the most likely at-fault party, he or she isn’t the only one. Bike-car accidents come in many different forms and have many different causes. These are just a few of the possible scenarios and how fault might be involved:
Being hit by a motor vehicle while on a bicycle can often lead to a permanent disability or serious injury. Because the type of injury you suffer will determine your need for medical care and how long your recovery will take, it is the single greatest factor affecting the amount of compensation you could be eligible for.
These are just a few of the injury types that your Riverside bicycle accident lawyer will have experience litigating claims for:
For you to have a personal injury case, someone else must be responsible for the accident. Even if you were partly to blame, you can file a lawsuit if someone else was more at fault than you were.
To determine fault, your Riverside bicycle accident lawyer will investigate your crash and review evidence such as accident reports, surveillance footage, and witness testimony. Evidence needs to be gathered to prove your claim, and this will form the foundation of the negotiations with the insurance company.
No matter how helpful the insurance adjuster might seem, never expect them to treat you fairly. Insurance companies are in business to make money, and they will do whatever they can to pay you as little as possible.
One of their tricks is to ask leading questions that they can then use out of context to pin blame on you. They’ll also try to lowball your offer and get you to agree to terms before you can get an attorney and find how much your claim is truly worth. Securing your own legal representation will prevent you from being taken advantage of in these ways.
You should receive compensation for every financial expense and non-economic damage inflicted by the accident. By working closely with your Riverside bicycle accident lawyer, you’ll be able to maximize the value of your claim and ensure that you don’t receive an inadequate settlement that falls short of covering all of your needs.
These are just a few of the items that will need to be considered:
The first step in collecting compensation for your accident is speaking with Kohan & Bablove, Injury Attorneys. We can review what happened, make sound legal recommendations, and represent you during both negotiations and trial.
To schedule a free consultation with a Riverside bicycle accident lawyer, call 1-844-404-2400 or complete the form below.

domain: law