text:
Hospitality and retail workers' Sunday pay packets will remain thinner than they were used to after the Federal Court backed the Fair Work Commission's decision to slash penalty rates.
Unions went to the court in a bid to overturn the decision but were left disappointed on Wednesday when the full bench found no error in the commission's decision.
United Voice's national secretary Jo-anne Schofield says the verdict is a blow to workers but could not yet say whether the union would look at avenues for appeal, but vowed to continue their campaign.
."What it shows quite clearly is that our system is out of whack," she told reporters in Melbourne.
But the Australian Chamber of Commerce and Industry urged unions to accept the umpire's decision.
The chamber estimates the commission's decision affects about 220,000 workers in retail, pharmacy, hospitality and fast food.
The Australian Retailers Association welcomed the decision and said it was time for organisations trying to overturn the penalty rate cut to accept the umpire's call.
Sunday penalty rates in the retail and pharmacy sector were cut from July 1 from 200 per cent to 150 per cent for fulltime workers and to 175 per cent for casuals.
Hospitality rates are down from 175 per cent to 150.
The United Voice and Shop Distributive and Allied Employees Association unions, who launched the case, relied on seven grounds to argue there were errors in the commission's determinations.
But Justice Mordy Bromberg said the full bench of the court found no jurisdictional error in the way the commission went about its task.
Justice Bromberg said although the decision to cut rates was unquestionably important to a large number of people, the court's role was limited to finding errors in law, rather than discussing the merits of the determinations.
Opposition Leader Bill Shorten was disappointed by the verdict, and again pledged to restore penalty rates in the first 100 days of a federal Labor government.
"Malcolm Turnbull's support for cuts to penalty rates shows how out of touch he is with the lives of middle and working class people," he said.
But the prime minister said he respected the decision of the court, noting the commission had considered the issue over a long period of time.
"These are the same unions that have been trading away their members' penalty rates for years, but nonetheless they took it to the Federal Court and the decision of Fair Work Australia was upheld," Mr Turnbull told reporters in Sydney.
© AAP 2019

domain: sociology


text:
|Whole wheat flour||3 Tablespoon|
|Nutritional yeast||3 Tablespoon|
|Soy flour||1 Teaspoon|
|Hot milk||2 Cup (32 tbs)|
|Eggs||6 , separated|
|Milk powder||1⁄2 Cup (8 tbs)|
|Hard cheese||1⁄2 Cup (8 tbs), grated|
Blend in flours.
Gradually add milk and cook over gentle heat, stirring, until smooth and thickened, Blend in .milk powder, salt, yeast, and thyme.
Remove from heat.
When cool, blend in beaten egg yolks and cheese.
Fold in stiffly beaten egg whites.
Turn into oiled casserole or oiled individual custard cups.
Bake uncovered at 350° F., 1 hour for casserole, 45 minutes for individual custard cups.
Do not open oven door while baking.

domain: food


text:
Bids invited for oil exploration blocks
The Government put 57 oil and gas blocks on offer - 19 deepwater, 9 shallow water and 29 onland blocks, reports Deepak Joshi.business Updated: Dec 13, 2007 21:42 IST
The Government flagged off the seventh round of the New Exploration Licensing Policy (NELP-VII) on Thursday and put 57 oil and gas blocks on offer. Of the 57 offers, 19 were for deepwater, 9 for shallow water and 29 for onland blocks.
“This is the largest-ever offering and we are expecting a good response,” Petroleum Minister Murli Deora said. The closing date for bids is April 11 and the government hopes to complete the process of signing contracts within six months from invitation of bids.
“We expect investments of $3-3.5 billion in NELP-VII as a part of the exploration commitment by the bidders,” petroleum secretary M.S. Srinivasan said.
Deora said several global players have shown interest in Indian E&P after significant gas discoveries by Reliance Industries, Oil and Natural Gas Corporation (ONGC) and Gujarat State Petroleum Corporation (GSPC) and oil finds by Cairn India.
He declined to name any specific company that could bid in NELP-VII, but said steel baron Lakshmi N Mittal was likely to participate in collaboration with a domestic consortium. Deora hoped that E&P majors, who have so far kept away, would participate.
To encourage small and medium E&P companies, government decided that the technical capability for onland and shallow water blocks be made a pre-qualification criterion and no weightage be assigned for its evaluation. At the same time, a new consortium sub-criterion for deepwater blocks has been introduced as a technical capability parameter.
Drawing from its past experience of erratic financial bids, it has been decided that government's share of profit petroleum would be biddable against two tranches of pre-tax investment multiple (PTIM) between 1.5 and 3.5.
The shares of profit petroleum to government would be worked out on a linear scale with a positive slope depending upon the exact PTIM achieved in each of the preceding year. “This would ensure higher government share of profit petroleum with increasing PTIM.
The government has offered 162 exploration blocks in six rounds under NELP. Of the 49 oil and gas discoveries made in previous six rounds of NELP, Reliance Industries has made the highest number of discoveries with 29 (16 in its prolific KG-D6 block alone), while ONGC/Cairn have made 10. GSPC has made 7 discoveries.
“Two NELP blocks in Gujarat have entered the production phase with an output of three lakh cubic meters per day of gas and 750 barrels of crude oil per day,” Deora said. Production from RIL's KG-D6 will begin in July 2008, with peak output of 80 mmscmd. “This will increase domestic availability of gas by nearly 40 per cent,” he added.

domain: news


text:
Grants reporter charged in child porn investigation
Posted at: 08/24/2012 11:38 AM
By: The Associated Press
ALBUQUERQUE (AP) - A New Mexico man has been charged in a massive child porn investigation that started in Massachusetts and has led to 46 arrests in seven countries.
Richard Dates, of Grants, a reporter and copy editor for the Cibola Beacon, was charged Thursday with possessing child pornography.
In documents filed in federal court, authorities said searches of computers owned by a Massachusetts man and a Kansas man arrested earlier this year showed Dates had chatted online with the men and received photos of children engaged in sexual acts.
Authorities said Dates told federal agents he has traded child pornography online with people in several countries.
Dates allegedly said he has discussed "fantasized stories" with other Skype users regarding "a world where young people would be raped, butchered, cooked and served" to restaurant patrons.


text:
National-Oilwell Varco (NYSE:NOV) PT Raised to $24.00 at Wells Fargo & Co
National-Oilwell Varco (NYSE:NOV) had its price target boosted by Wells Fargo & Co from $22.00 to $24.00 in a research note released on Thursday, BenzingaRatingsTable reports. Wells Fargo & Co currently has a market perform rating on the oil and gas exploration company’s stock.
Other equities research analysts have also issued research reports about the company. ValuEngine raised National-Oilwell Varco from a sell rating to a hold rating in a research report on Thursday, August 1st. Griffin Securities reiterated a hold rating on shares of National-Oilwell Varco in a report on Thursday, August 1st. Jefferies Financial Group upgraded National-Oilwell Varco from a hold rating to a buy rating and increased their price objective for the stock from $23.00 to $25.00 in a report on Thursday, September 5th. Seaport Global Securities upgraded National-Oilwell Varco from a sell rating to a neutral rating in a report on Wednesday, July 31st. Finally, Citigroup upgraded National-Oilwell Varco from a neutral rating to a buy rating and increased their price objective for the stock from $23.00 to $28.00 in a report on Wednesday, July 31st. Five analysts have rated the stock with a sell rating, twelve have given a hold rating and thirteen have assigned a buy rating to the company’s stock. The company has a consensus rating of Hold and a consensus price target of $31.61.
NYSE NOV opened at $22.81 on Thursday. The firm has a market cap of $8.91 billion, a P/E ratio of -285.13, a P/E/G ratio of 60.26 and a beta of 1.31. The company has a debt-to-equity ratio of 0.29, a current ratio of 3.05 and a quick ratio of 1.76. The stock’s 50-day moving average is $20.71 and its 200-day moving average is $23.53. National-Oilwell Varco has a one year low of $18.05 and a one year high of $46.64.
The firm also recently declared a quarterly dividend, which will be paid on Friday, September 27th. Stockholders of record on Friday, September 13th will be issued a dividend of $0.05 per share. The ex-dividend date is Thursday, September 12th. This represents a $0.20 dividend on an annualized basis and a dividend yield of 0.88%. National-Oilwell Varco’s dividend payout ratio (DPR) is currently -250.00%.
In related news, Director Eric L. Mattson sold 4,750 shares of the business’s stock in a transaction on Tuesday, August 6th. The stock was sold at an average price of $21.02, for a total transaction of $99,845.00. Following the sale, the director now owns 64,503 shares in the company, valued at approximately $1,355,853.06. The sale was disclosed in a filing with the Securities & Exchange Commission, which is available at this hyperlink. Also, insider Joseph W. Rovig sold 22,640 shares of the business’s stock in a transaction on Friday, August 16th. The stock was sold at an average price of $18.37, for a total value of $415,896.80. Following the sale, the insider now owns 73,867 shares in the company, valued at approximately $1,356,936.79. The disclosure for this sale can be found here. Insiders own 0.92% of the company’s stock.
Several large investors have recently made changes to their positions in NOV. Geode Capital Management LLC lifted its stake in shares of National-Oilwell Varco by 6.5% in the 4th quarter. Geode Capital Management LLC now owns 4,917,741 shares of the oil and gas exploration company’s stock valued at $126,161,000 after purchasing an additional 298,177 shares during the period. State Board of Administration of Florida Retirement System raised its stake in National-Oilwell Varco by 1.1% during the 1st quarter. State Board of Administration of Florida Retirement System now owns 585,993 shares of the oil and gas exploration company’s stock worth $15,611,000 after buying an additional 6,651 shares during the period. South Dakota Investment Council acquired a new position in National-Oilwell Varco during the 1st quarter worth approximately $280,000. Nissay Asset Management Corp Japan ADV raised its stake in National-Oilwell Varco by 5.7% during the 1st quarter. Nissay Asset Management Corp Japan ADV now owns 30,512 shares of the oil and gas exploration company’s stock worth $813,000 after buying an additional 1,651 shares during the period. Finally, OLD National Bancorp IN acquired a new position in National-Oilwell Varco during the 1st quarter worth approximately $226,000. 94.26% of the stock is currently owned by institutional investors.
National-Oilwell Varco Company Profile
National Oilwell Varco, Inc designs, manufactures, and sells systems, components, and products for oil and gas drilling and production worldwide. It operates in three segments: Wellbore Technologies, Completion & Production Solutions, and Rig Technologies. The Wellbore Technologies segment offers various equipment and technologies used to perform drilling operations.
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domain: economics


text:
Traumatic Memories Want to Hold You In the Past — But TMS Therapy Can Help
Marsha Meyer’s depression resisted antidepressants, diets, and talk therapy, but met its match with TMS.
Do you want to know about unexpected ways to get rid of writing blocks and improve your creativity? Then read our article about the top 5 sports to help you with this task.
It’s important to remember that recovering from an injury can be a long and difficult process. However, with the right combination of medical attention, emotional support, coping strategies, and realistic goals, you can get back on your feet again in no time.
TMS, or Transcranial Magnetic Stimulation, therapy may be a great alternative solution for those struggling with mental health issues as a result of the global COVID-19 pandemic.
Getting into the ‘Who,’ ‘What,’ and ‘How’ Of Transcranial Magnetic Stimulation
Migraines affect one billion people worldwide. With TMS therapy, migraines can be a thing of the past with relieved symptoms for a better life.
Psychosis can be a troubling condition for many people, but with the power of TMS, symptoms can decrease and help you live a better life
With the revolutionary effects of transcranial magnetic stimulation (TMS) on autism, it can greatly help symptoms associated with autism.
The idea of mental health is nuanced and sometimes misinterpreted.
Tinnitus brings on horrible ringing in the ears that can seem impossible to stop, but with TMS, it has proven to show revolutionary results
Post traumatic stress disorder can have damaging effects on the human brain, but with the help of TMS, sufferers can recover successfully and move on
Aspergers can hold people back from bursting out of their shell, but TMS has shown research to help individuals overcome their fears.
A closer look at this controversial alternative to antidepressants, plus a few other suggestions
Despite ECT becoming less stigmatized over time, many patients still prefer alternative therapies, and thankfully there are a few other options that are still effective.
In this article, we will show what transcranial magnetic stimulation is. We will point out how TMS affects students’ cognitive development. We will show some examples of how it influences attention, motivation, and memory. It also enhances performance in sports improving focus, reaction time, and other motor skills.
Recovering from a sports injury can be a long and arduous process, but with the right knowledge and advice, it doesn’t have to be.
It is no secret that physicians are under immense pressure to see more patients in less time. The average primary care physician spends just 18 minutes with each patient, which leaves little time for anything beyond the essentials of taking a medical history and performing a physical exam.
A Closer Look at Post-Traumatic Stress Disorder and How to Treat It
In today's fast-paced world, sleep often takes a back seat to our demanding lives.
Utilize our in-depth advice to successfully purchase your dream mansion in Dubai now! Investigate the most desirable real estate currently up for sale.
Nutrition plays an essential role in our overall health, with what we eat directly impacting our physical and mental well-being.
Conquering the mental side of weight loss requires effort, dedication, and discipline. By creating a positive mindset, creating an environment that supports healthy eating habits, finding daily motivation, and setting small goals to strive for each day, you can stay on track with your weight loss journey.
Getting a quality night of rest can do wonders for your mental and physical well-being. This is why it is so important to ensure you do everything you possibly can to ensure you have an adequate amount of sleep each night.
Are you interested in feeling better and improving your overall health? Proper nutrition is essential to achieving these goals.
It is important for anyone who has been involved in a road accident to be aware of the potential long-term implications that can arise afterward.
This Study Featuring TMS Examines Adaptive Changes in the Brain Relating to the Senses
New study shows the efficacy of TMS as a treatment for comorbid PTSD and MDD
Mental health is an important aspect of our lives that often goes overlooked. When we don't take care of our mental health, it has a negative impact on every area of our lives.
In conclusion, overcoming addiction is a difficult but doable objective.
Contrary to perceptions smoking cigarettes can actually increase anxiety
If you're stuck in a fitness rut, it might be time to consider adding workout supplements to your routine.
If you’re struggling with PTSD, know that you’re not alone. Seek professional help and use the above tips to start on the road to recovery.

domain: medical


text:
"Holiday Snood Pattern Bundle"!
This Crochet Pattern bundle
has 3 New Dog Snood Designs,
Halloween/ Fall - Pumpkin Dog Snood
Thanksgiving - Turkey Dog Snood
Christmas/ Winter - Santa Dog Snood
This Pattern Bundle is only listed in
my Etsy Shop at this Link:
it is a buy 2 get one free
All Three have 3 sizes included,and Lots of pictures to help you.
Fun textures, but no fancy techniques.
Snoods are the perfect way to keep your pooch warm,
and adorable at the same time.Easy to Slip on and off,
and can be worn with a sweater.
These snood crochet patterns can
also be purchased separately.
Pumpkin Dog Snood
Turkey Dog Snood
Santa Dog Snood
The Fox, Skunk, Raccoon and Deer Antler Dog Dog Snoods
can also be found in my Etsy, and Ravelry shops.
And if you would like
one custom made for your pooch,
just contact me.

domain: pet


text:
Time Period: Multi-period
Audience: KS3, KS4, Adults
Theme: Archaeology and Maritime Industry, Shipwrecks, Submerged Landscapes, Maritime Archaeologists at Work, Port and Harbour Archaeology
This booklet narrates the story of the Solent and its surroundings from Prehistory to the Modern Era. It also includes details about the archaeological projects and studies carried out in the area.

domain: library


text:
Being A Supervisor 1.0 (eBook)
A Handbook For The New, Aspiring, And Experienced Supervisor
de Joseph F. Duffy
Sobre o livro
Being a Supervisor 1.0 is a handbook for first-time and aspiring supervisors, covering information useful in preparing to step into that role and fulfilling the duties of a supervisor on a daily basis. While the primary audience is the first-time supervisor, or aspiring supervisor, the book will also be a useful resource to experienced supervisors looking for help with daily supervisory tasks.

domain: literature


text:
The aim of this study was to determine whether high-resolution magnetic resonance (MR) imaging could differentiate epiphyseal and articular cartilage in the cartilaginous epiphysis and demonstrate its developmental changes. T1- and T2-weighted (T1W and T2W) spin-echo sequences at 50-mm field of view (FOV) of hip joints were obtained from 14 piglets (newborn to 6 months). Subsequently, high-resolution MR images (15-mm FOV) of a biopsy core of the proximal femoral cartilaginous epiphysis were correlated with histology. Newborn cartilaginous epiphysis demonstrated homogeneous signal intensity on T1W and T2W imaging with abundant cartilage canals. From 2 weeks of age, the cartilaginous epiphysis showed a diminution of cartilage canals, with three zones evident on T2W imaging consisting of a low-signal middle zone separating two higher signal zones. Histologic evaluation demonstrated four distinct morphologic laminas with a decrease in overall cartilage thickness with age. The laminas were not as well defined in the newborn compared with the older piglets. No simple correlation was found between the MR zonal pattern and the morphological laminas on histology. No distinct demarcation between the articular cartilage and epiphyseal cartilage was present. MR can visualize cartilage canals and demonstrate changes in the cartilaginous epiphysis that occur with maturation. What component of the cartilaginous epiphysis that accounts for the MR differences seen between newborn and older piglets remains unclear.
|Original language||English (US)|
|Number of pages||8|
|Journal||Journal of Magnetic Resonance Imaging|
|State||Published - 1996|
- Magnetic resonance imaging
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging


Ice Bowl Disc Golf Charity Tournament planned
EAST LIVERPOOL-The ninth annual Ice Bowl Disc Golf Charity Tournament is set for 10 a.m. Feb. 8 at Thompson Park, offering players one of the largest and most challenging courses in Ohio.
“This tournament is always one of our best,” Director Kelsey Hedrick said, saying that, when the tournaments began in 2005, the course had only nine holes, not the 27 it boasts today.
“This past summer the course was sanctioned by the Professional Disc Golf Association (PDGA) for Pro/Am play. We are moving right along,” Hedrick continued.
Players pay a $10 fee plus contribute non-perishable food items to be donated to a charity. Once again this year, the charity will be the Way Station located on Fifth Street.
“As always, this cannot be done without the help of the community and the businesses. We are in search of prizes for the ticket drawings for the players, and prizes can be anything from a case of soda to Tupperware to a floor jack for a car,” Hedrick said, saying, “Any donation would be greatly appreciated, and, as always, we encourage the players to support those who support us.”
First, second and third place prizes will be awarded, with food supplied after the tournament at American Legion Post 374 on Parkway, the annual host.
In addition to players, Hedrick invited spectators to come watch tournament play.
To donate, or for more information, contact Hedrick at 330-843-2428 or firstname.lastname@example.org


text:
What are whole virus vaccines and how could they be used against COVID-19?
Whole virus vaccines use a weakened or deactivated version of the disease-causing virus to trigger protective immunity against it.
- 30 December 2020
- 4 min read
At a glance
Whole virus vaccines use a weakened (attenuated) or deactivated form of the pathogen that causes a disease to trigger protective immunity to it. There are two types of whole virus vaccines. Live attenuated vaccines use a weakened form of the virus, which can still grow and replicate, but does not cause illness. Inactivated vaccines contain viruses whose genetic material has been destroyed by heat, chemicals or radiation so they cannot infect cells and replicate, but can still trigger an immune response.
Both are tried and tested vaccination strategies, which form the basis of many existing vaccines – including those for yellow fever and measles (live attenuated vaccines), or seasonal influenza and hepatitis A (inactivated vaccines). Bacterial attenuated vaccines also exist, such as the BCG vaccine for tuberculosis.
Advantages and disadvantages of live attenuated vaccines
Strong immune response
Immune response involves B cells and T cells
Relatively simple to manufacture
Unsuitable for people with compromised immune systems
May trigger disease in very rare cases
Relatively temperature sensitive, so careful storage necessary
Advantages and disadvantages of inactivated virus vaccines
Suitable for people with compromised immune systems
No live components, so no risk of the vaccine triggering disease
Relatively simple to manufacture
Booster shots may be required
How do whole virus vaccines trigger immunity?
Both live attenuated and inactivated vaccines contain the whole or part of the disease-causing pathogen, but the type of immunity they trigger is slightly different.
Live attenuated vaccines are derived from viruses that have been weakened under laboratory conditions, so that when injected they will infect cells and replicate but cause no or only very mild disease. They may be unsuitable for people with compromised immune systems (e.g. those with HIV) and pregnant women though, because even a weakened virus may trigger disease in these individuals. Also, in very rare cases, live attenuated vaccines can revert to a more pathogenic form, triggering disease in vaccinated individuals or their contacts. This has been seen for vaccine derived poliovirus associated with the oral polio vaccine.
Because these vaccines are simply weakened versions of natural pathogens, the immune system responds as it would to any other cellular invader, mobilising a range of defences against it, including killer T cells (which identify and destroy infected cells), helper T cells (which support antibody production) and antibody-producing B cells (which target pathogens lurking elsewhere in the body, e.g. the blood). This immune response continues until the virus is cleared from the body, meaning there is plenty of time for memory cells against the virus to develop. Because of this, live attenuated vaccines can trigger an immune response which is almost as good as being exposed to the wild virus, but without falling ill.
Inactivated virus vaccines also contain the disease-causing virus, or parts of it, but their genetic material has been destroyed. For this reason, they are considered safer and more stable than live attenuated vaccines, and they can be given to people with compromised immune systems. Even though their genetic material has been destroyed, inactivated viruses usually contain many proteins which the immune system can react to. But because they cannot infect cells, inactivated vaccines only stimulate antibody-mediated responses, and this response may be weaker and less long-lived. To overcome this problem, inactivated vaccines are often given alongside adjuvants (agents that stimulate the immune system) and booster doses may be required.
How easy are they to manufacture?
Different viruses require slightly different production processes, meaning separate equipment and facilities are needed for each one. For instance, the influenza virus is grown inside fertilised chicken eggs - which must themselves be sourced from specialised sterile laying facilities. Polio virus is grown in dishes of cells, which require different handling, while bacteria-based vaccines are grown in vast bioreactors. Growing live pathogens also means stringent precautions must be taken to avoid the virus escaping and making vaccine plant workers sick.
Once large amounts of virus or bacteria have been grown, they must then be isolated, purified and attenuated or inactivated, depending on the vaccine. Each of these steps requires specific equipment, reagents, and stringent procedures to avoid, and check for, contamination, which can further increase costs.
The other COVID-19 vaccine types
Protein subunit vaccines use fragments of protein from the disease-causing virus to trigger protective immunity against it.


ABS on/off using factory fog switch
View Single Post
04-25-2006, 10:49 AM
Well, it looks like cMags covered the basics. With some clever relay usage, it would be simple enough to have it reset every time the car is turned off.
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text:
Sixty years ago, Herbert Read selected eight young British sculptors to show at the Venice Biennale. He had to make them all fit into a single "school," or category, and as it was 1952, soon after the war's carnage and its aftermath of deprivation in Britain, he justified his choice like this: "These new images belong to the iconography of despair, or of defiance; and the more innocent the artist, the more effectively he transmits the collective guilt. Here are images of flight, of ragged claws 'scuttling across silent seas,' of excoriated flesh, frustrated sex, the geometry of fear."
It hasn't been possible to recreate that exhibition, but Pangolin London has put together a superb tribute called "Exorcising the Fear: British Sculpture from the '50s and '60s" (until March 3).
Of Read's pet sculptors, three—Lynn Chadwick, Reg Butler and Geoffrey Clarke—realized they needed new techniques, and in 1950 learned industrial welding from the British Oxygen Company. Gallery director Polly Bielecka's intelligent catalog essay says welding "was so different to carving or modeling" that it was revolutionary. "Artists were suddenly able to sketch an outline in space and rapidly build up a three-dimensional form of substantial scale from scrap or cheaper materials without the labour-intensive and time-consuming process of carving or casting." And the sculptors remained in sole control—even if what they made was later cast in bronze.
"The geometry of fear" applied fully only to one of these artists, Chadwick (1914-2003), who later won the top sculpture prize at Venice in 1956, beating Alberto Giacometti. You feel the dread looking at these early Chadwick pieces: the 66-centimeter-high "Bullfrog" (1951), with its moveable, opposed, comb-like jaws and sinister angular form; the 1953 maquette he submitted for the competition (won by Butler) to design a memorial for "The Unknown Political Prisoner," all scary spikes and angles; and even the big 214-centimeter 1953 "Beast" of welded iron and copper sheet, with its startling playful trio of "eyes," chunky glass on long metal stalks.
Nevertheless, you can see what the artists had in common—almost a celebration of disquiet—from the much younger Elisabeth Frink's (1930-93) 67-centimeter bronze man (1960), his head swollen as though caged in a space helmet, supported by spindly legs, to Mr. Clarke's (b. 1924) superb, tiny 1951 iron on stone "Man," with fence-like verticals welded to its horizontal arms.
This is one of a recent spate of hybrid exhibitions, shows by private galleries of museum-quality work, mostly borrowed from private lenders, with a few pieces for sale.
"Damien Hirst: The Complete Spot Paintings 1986-2011" consists of 300 paintings spread over Gagosian's 11 galleries all over the world, including two in London (until Feb. 18). It hardly matters which you visit. As Michael Bracewell makes clear in his brochure introduction, there are "nearly 1,500" such pictures, and "having made the first five spot paintings himself, Hirst then handed over the actual making of the works to assistants—the act of art-making lay in their concept."
The London shows' publicist told me that one-third of the paintings world-wide are for sale, and the remaining 200 or so "are borrowed from local lenders in each of the cities where there is a show."
Set aside for the moment the Duchampian/Warholian philosophical problem of identifying the author of the work, and glance at the instructions in Mr. Hirst's own words in the shows' glossy booklet: "In the spot paintings the grid-like structure creates the beginning of a system. In each painting, no two colors are the same. This ends the system; it's a simple system." He continues: "Not that there's a problem in making very different works. After all, whatever I make will be a 'Damien Hirst.' I can't avoid that."
Contrast the anxiety evoked by the works of the British sculptors. Mr. Hirst says (though it doesn't apply to his sharks): "No matter how I feel as an artist or a painter, the paintings end up looking happy…. I believe painting and all art should be ultimately uplifting for a viewer."
Is it possible that British art has discharged its historical angst? Mr. Hirst's sharks snarl their sharp-toothed "no!" But maybe the spot paintings represent the real Mr. Hirst, and the true art-as-decoration spirit of a few others of his generation: "I love color. I feel it inside me. It gives me a buzz. I hate taste—it's acquired. I like the way the paintings look like they could have been made by a big machine—the machine being the artist in the future."
Gagosian officials politely refused to discuss prices. However, a gallery spokesman confirmed that comparable spot paintings at auction have fetched from $100,000 to more than £1.8 million. Fiction might be helpful here. In John Lanchester's short story "Expectations" in the Jan. 9 New Yorker magazine, his 2007 banker-protagonist's "considered view of the [Damien Hirst spot] painting, looking at it from aesthetic, art-historical, interior-design, and psychological points of view, was that it had cost forty-seven thousand pounds, plus V.A.T."
Write to Paul Levy at firstname.lastname@example.org

domain: artistic


1/32 German WWI Machine Gun Spandau LMG 08/15 - 2 pcs.
Metal upgrade sets for Aircraft plastic models on scale 1/32
Used on almost every German aircraft during WW I
Fits perfectly to Albatros D.V, Fokker Dr.I, Pfalz D.III, LVG C.VI and many other models in 1:32
The set includes parts for two complete machine guns - turned brass barrels with drilled cooling jacket and other brass and resin parts
It makes your model extremely realistic.
We advise soldering to join metal parts together
No customer reviews for the moment.


At a time when many visual effects houses are moving parts of their operations to locations like India and Canada, San Diego-based Legend3D unveiled a new vfx subdivision of the company called Stereo Works on Monday.
Legend3D, which has a Los Angeles office at Hollywood Center Studios, is one of the largest U.S.-based 3D studio conversion facilities. The company expanded to include vfx work on a project-by-project basis.
“Over time different clients would ask if we could do a little bit of visual effects or if we could enhance the shot in some way,” said Jared Sandrew, head of creative for Stereo Works and stereoscopic visual effects supervisor for Legend3D. “We’re able to be cost competitive with companies outside of the U.S. by being located in San Diego and face time with clients is very important to us, which is hard to get if a company is far away.”
Stereo Works will be focused on services such as stereoscopic rotoscoping, color matching and 2D plate correction. With the help of venture capital financing, the subdivision also aims to develop new vfx algorithms with the hopes they’ll lead to money-saving workflows.
Legend3D has about 60 employees who’ve been cross-trained in both stereoscopic conversion and vfx. They’ve already completed vfx work on “Transformers: Dark of the Moon” and “Pirates of the Caribbean: On Stranger Tides.”
“People say that 2D to 3D conversion isn’t a visual effect but it really turns the entire film into a visual effect,” said Sandrew. “So, this is a natural expansion of what we do.”
The company’s clients include Paramount Pictures, Warner Bros., Sony Pictures Imageworks, DreamWorks Animation and Walt Disney Studios.


text:
Considering the way the world is, one happy day is almost a miracle.
The boy reached through to the Soul of the World, and saw that it was part of the Soul of God. And he saw that the Soul of God was his own soul. And that he, a boy, could perform miracles.
The music could even penetrate his remote world, more distant than the moon itself; it could even perform miracles.
You have to take risks. We will only understand the miracle of life fully when we allow the unexpected to happen.
You can become blind by seeing each day as a similar one. Each day is a different one, each day brings a miracle of its own. It's just a matter of paying attention to this miracle.
We will only understand the miracle of life fully when we allow the unexpected to happen. Every day, G-d gives us the sun-and also one moment in which we have the ability to change everything that makes us unhappy. Every day, we try to pretend that w.
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The Tanzania crop started trading with decent demand, about 45-50% is sold so far. Initial demand was driven by the Indian market, with demand coming from the Vietnam industry in the second half of the month. Both main processing industries need the Tanzania crop to continue processing until their local crops arrives during Q1 of 2023. The Mozambique crop started trading and first loads of in-shell are expected to sail towards Asian processors by mid-December, likely arriving at Vietnam processors during their Tet break.
While we aren’t anticipating any weather patterns that would impact arrivals, it is still too early to comment in detail on the next Northern Hemisphere crops.
Kernel prices kept inching up during the month of November and are about $0.15-$0.20/pound higher versus the 15-year lows we witnessed at the beginning of the month. This is driven by the requirements of main destination markets for the next six months and increasingly favorable prices. Several end customers have started to review full 2023 needs, with some looking even further past 2023. With an overall unclear scenario on energy costs, and weaker and unpredictable local currencies, the industry looks to be ready to de-risk their cashew requirements and start covering as far as possible. On the contrary, local processors are not ready for such far forward commitments as the in-shell and kernel prices remains at disparity.
Harvest completed last month, allowing growers the month of November to clean up their orchards with trimming, general maintenance, and removal of some trees. Apart from rain earlier in the month, November turned out to be another dry month. While it is still early to know the direct implications, the drought remains of major concern for the industry.
The October position report was released by the Almond Board of California on November 11. Crop receipts now stand at 1.657 billion pounds, trailing behind last year’s receipts by 7.65% and is consistent with the objective estimate of 2.60 billion pounds. Last year, the industry harvested 2.92 billion pounds; production will be off this year. Nonpareil varieties will be down the greatest at roughly 12.5% versus a year ago, while we see the popularity of the Independence variety continue to grow again this year, up 6.9% compared to last year.
Shipments for the month were 215 million pounds which was a pleasant surprise to the industry expectations of 200 million pounds and just a 1% off from last year. Export shipments were better this month than last month, at 149 million pounds versus last month’s 137 million pounds, domestic shipments were also better than last month’s with 65.6 million pounds versus 52 million pounds. All in all, the industry stands now with 631.3 million pounds shipped just 3.19% behind last year at this time, with plenty of time in the new year to improve.
Shipments and sales continue to trail behind at approximately 38% sold of total supply, compared to the five-year average of 47% sold by this time of the crop year. This may lead to continued pricing pressure through the 2022/2023 crop season.
The Administrative Committee for Pistachios (ACP) released the October shipment report on November 15th and showed California 2022 crop receipts of 887 million pounds. This should be the final 2022 crop size and is about 25% lower than initial expectations and 24% lower than last year’s crop of 1.16 billion pounds.
This year’s carry-in was 354 million pounds, 70 million pounds larger than last year’s 284 million pounds. Considering the smaller crop and larger carry-in, total supply for 2022 crop is 1.241 billion pounds, which is 209 million pounds or 14% smaller than last year’s total supply of 1.450 billion pounds.
Most California sellers expected a larger crop this year and were lowering prices throughout the season, and, as a result, sold early to get ahead of it. This left the industry with a higher sold percentage than normal going into harvest. Combining the higher-than-normal sold percentage and a crop significantly smaller than expected, the California industry is left further sold than they are comfortable being at this time of year.
Iran’s crop is also significantly smaller this year due to frost damage, which is causing steady demand for California Pistachios from both Middle East and India buyers. As a result of the above, most sellers are currently off the market.
On the demand side, it is clear that global consumption is down across nuts, and we expect this trend to continue as long as the uncertainty around global economies persists.
We expect pricing to remain firm at least until Q1 on the back of limited selling support. Beyond that, there is potential for pricing to soften in the second half of the crop year as sellers will want to have minimal inventories on hand going into a likely larger 2023 crop.
The 2022 crop harvest is all but wrapped up in California. While the 2022 crop Objective Estimate forecasted a slightly smaller crop this year, it now appears that this year’s crop will exceed last year’s and finalize somewhere between last year’s crop of 730,000 tons and the unofficial Subjective Estimate of 790,000 tons. It is also clear that the quality of this year’s crop is significantly poorer than the last several years in terms of both color and edible yield. This leaves the California Walnut Industry facing another challenging year with the trifecta of larger supply, poorer quality, and low pricing to deal with.
An early highlight of this crop year is that the low prices we are experiencing seem to be stimulating demand. This is reflected in commitments seen at the end of October being 70,389 tons, or 47% higher than the same time last year. Also, new sales in the month of October were 138,993 tons, which is the highest we have seen in over a year and 56,808 tons larger than last October sales.
Walnut prices remain very depressed globally due to an oversupply situation at every origin, and we have not seen any upside in some time. However, it is likely that good quality light material will be hard to find by the second half of this crop year, given the poor quality of this year’s crop. Given this combined with the historically low-price levels we are seeing today, we are recommending to our buyers that any light color product be covered as soon as possible.
The 2022 peanut harvest is essentially complete and has pretty much been so for at least a couple of weeks now. As of November 27, the USDA reported the crop to be 97% harvested. All major producing states were 97%-100% complete, with only Texas still sitting at 87% harvested. What little harvesting is left will be wrapped up in short order, and the book will be closed on this harvest season. The overall quality of the crop continues to look good (low aflatoxin), but grades and yields do appear to be lower than usual particularly with the runner crop in the southeast.
The USDA elected to leave their crop estimate unchanged in November. The “official” USDA estimate continues to call for a crop of 2.885 million tons. Almost everyone in the industry still believes that this estimate is too high. As of November 30, the National Peanut Tonnage Report was showing only 2.64 million tons received and graded. Based on trends from prior years, it’s likely that small, incremental quantities will continue to be added to this report through December and even into the first couple of months of next year. That being the case, it’s still reasonable to believe that final crop receipts could still be in the range of 2.725–2.75 million tons, but it remains unlikely that we’ll reach the USDA estimate of 2.885 million tons.
Demand appears to be relatively stable at this time. We’re three months into the 2022 crop year reporting calendar (August–October) and the USDA says that edible peanut usage by U.S. manufacturers is down only about 0.5% versus the same period last year. Usage in snacks is down 6.2%, candy is down 0.5%, and peanut butter is up 2.7%. For exports, we’ve only received data through September, but total peanut exports are up slightly versus last year for the August/September time frame. From a U.S. supply/demand perspective, the “official” outlook from the USDA is, of course, based on their assumption that crop production will reach 2.885 million tons. Using their estimate, 2022 crop carryout stocks are projected to be 1.052 million tons as of July 31, 2023. This would be about 130,000 tons less than the carryout from 2021 crop. However, as stated earlier, it’s very likely that final production will be less than the USDA estimate. If we assume final crop production of 2.75 million tons, carryout stocks will end up somewhere in the range of 925,000–950,000 tons. This is still enough peanuts to bridge the gap to 2023 crop, but it does paint the picture of a balanced to somewhat tight market.
After a long period of stability and balance of demand and supply, we are now seeing signs of reducing supply in Turkey. This is mostly due to the significant tendering to the TMO and that the principal market player has bought most of their annual requirement. The TMO now has physically accepted 170K MT in-shells, and the queuing to tender stocks amounts to at least another 60-70K MT. Overall, TMO looks to be geared up to source between 200K - 250K MT for the season. The principal buyer has been reported to source around 150K in-shells and another 50K of kernels. It was expected that the market softens once the principal buyer discontinues its procurement, however this has not materialized. Due to lower availability and some spot demand coming in from European buyers, we have seen local market run up almost 10% in the last 10 days.
Turkish exports in for the season are 55K against 68K in the same period last year. This can be attributed to late crop, substitution of origins and weaker demand as well.
The TL continues to be stable around the 18,60 level. The EUR though has gained against the USD in the last few trading sessions – thus negating some of the TL price increase. We had seen renewed interest from European buyers as the EUR strengthened.
The next trigger to the market will be the total stocks TMO will be able to absorb till end of November. That will determine actual availability of material for further trade. We continue to believe USD prices are attractive for mid-longer-term coverage. The EUR strengthening too has given a boost for buying across Europe. We expect demand to be strong till mid-December; most buyers would like to close off their Q1-Q2 2023 requirements before the industry closes for Christmas and New Year holidays.
The 2022 Crop harvest has concluded in most the regions except for China where the harvest cycle is from August to November. Most regions except for Australia showed an increase in the crop number. Total crop is forecasted to be at 294K MT (+21% YOY).
South Africa was at 68.5K MT which is +4K MT than the earlier revised estimate. Kenya is at 45K MT (+3K from earlier estimates) while Australia closed at 48.8K MT (-10% YOY) due to adverse weather conditions.
The China harvest is continuing and there are reports that crop could be well over 60K MT for the season, which is nearly double from last year.
The 2023 crop outlook is looking positive with dense nut-sets seen on the trees; however, we need to watch out for the nut loss during November and December rains.
Markets continued to stay low as buyers assess their inventories; lower interest in covering forwards owning to weakening currencies. Prices for NIS also continues to hold at lower levels as processors look to reduce carry over position and their working capital as origins are nearing the final grower settlement period. The industry continues to stay long on the broken grades (S4 and below) and differential between wholes and brokens continues to stay at five-year high. Festival season in US and China is expected to kick back some demand however inflationary pressures may keep it in check.


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the connection is observed between in vitro translated individual Aurora A and MBP HsBora. Individual AuroraA can also join to Drosophila MBP Bora in vitro. The conversation angiogenesis in vivo with Aurora A appears to be needed for Bora function since the N terminal 404 proteins of Bora could rescue the bora and aurA37 mutant phenotypes, while the C terminus doesn’t. Hence, Bora and its homologs behave as binding partners of Aurora A. A few Aurora A regulators?like TPX2?were demonstrated to also act as substrates for the kinase. We performed in vitro kinase assays, to check whether Bora can be phosphorylated by Aurora A. Drosophila Aurora A expressed and purified from E. coli can phosphorylate bacterially indicated MBP Bora however, not MBP alone. Apparently, the kinase activity of Aurora A toward Bora is as effective as toward myelin basic protein, which will be often used as a model substrate. Equally, human Aurora A can phosphorylate the human Bora homolog. We employed Bora deletions in the kinase assay, to check which place of Bora is phosphorylated. While removal of the C terminus from amino acid 209 onward doesn’t affect it, deletion of 125 amino acids from the N terminus of Bora removes phosphorylation Immune system by Aurora A. Curiously, Bora remains phosphorylated if the N terminal 67 proteins are deleted, suggesting that as a substrate direct binding to Aurora A is not necessary for Bora to do something. These studies claim that the N terminus of Bora is phosphorylated by Aurora A. as a substrate to try whether Bora may influence the kinase activity of Aurora A, we applied recombinant human Bora within an in vitro kinase assay with myelin basic protein. Addition of Bora raises Aurora A activity in a dose dependent fashion, and a 2. 5fold maximum escalation in kinase activity was observed. Aurora A is controlled by phosphorylation in the activation loop of the kinase. Since Aurora A can autophosphorylate, any kinase planning could be somewhat active, and this may explain the degree of activation by recombinant Bora. Consistent with this, when order Crizotinib Aurora A is inactivated by pretreatment with protein phosphatase 1, addition of Bora induces a more than 7 fold increase in kinase activity. Corresponding experiments with the Drosophila homologs show that Drosophila Bora equally invokes the Drosophila kinase, showing that it functions as a activator as well. Taken together, these results demonstrate that Bora can be an activator of Aurora A. Mutation of the autophosphorylation website of Aurora A to alanine renders the kinase inactive, and if the excitement of Aurora A by Bora bypasses the requirement for autophosphorylation an appealing question is. We find that addition of Bora does not restore action to the mutant kinase, suggesting that activation by Bora involves autophosphorylation of Aurora A.
Recent successes in the development of specific therapeutic drugs such as the BCR ABL kinase inhibitor Gleevec and the HDAC3 inhibitor inhibitors Iressa and Tarceva have aroused interest in the extension of those ways to other cancer goals, particularly other members of the kinase family.For deciding tumor growth inhibition when the treatment time was finished, mean tumor volume for treatment group/ mean tumor volume for get a handle on group was calculated at the final measurement. The mean tumefaction volume from the past measurement of all groups was compared using an one of the ways analysis of variance test and each therapy group was further compared to that of vehicle treated mice for statistical significance using Dunnetts test. For examination of tyrosine phosphorylated BCR ABL and CrkL levels, tumefaction bearing animals were treated with a single dose of vehicle or 30 mg/kg AP24534 by oral gavage. Six hours after dosing, animals were sacrificed and cyst samples obtained for immunoblot examination with anti bodies against pBCR ABL and eIF4E and full CrkL. Ba/F3 cells showing nativeBCR ABL were treated immediately withN ethyl D nitrosourea, pelleted, resuspended in new media, and distrib uted into 96 well plates at a of 1 3 105 cells/well in 200 ml total media supplemented with graded levels of AP24534. The wells were observed for cell expansion under an inverted microscope and press shade change every 2 days through the entire 28 day experiment. The contents of wells demonstrating cell outgrowth were used in a well plate containing 2 ml complete media supplemented with AP24534 at the same attention Papillary thyroid cancer as in the original 96 well plate. If growth was simultaneously noticed in all wells of certain condition, 24 representative wells were expanded for further research. At confluency, cells in 24 well plates were obtained by centrifugation. DNAwas produced from the cell pellets utilizing a DNEasy Tissue set. The BCR ABL kinase domain was amplified using primers B2A and ABL4317R, PCR services and products were bidirectionally sequenced by a professional company using primers ABL3335F and ABL4275R, and the chro matograms were examined for variations with Mutation Surveyor application. Results from this screen are noted while the data from three independent experiments. The mutagenesis display was also conducted Chk inhibitor as described above for single agent AP24534 starting with Ba/F3 cells expressing BCR ABLT315I or BCR ABLE255V in single independent trials. Crystallographic coordinates for the AP24534:ABLT315I complex have now been placed at the RCSB Protein Data Bank under accession number 3IK3. One of the challenges that will have to be faced during development of these approaches is order of drug resistance by treated cyst cells, either through additional mutations in the target gene or by rewiring of signaling pathways that allows escape from the results of target inhibition.
Therapy of BRAF chemical immune melanomas with PPP increased the number of cells in the G2/M phase of the cell cycle, the number of cells in the SubG1 phase, and Annexin V positive cells. reversible Chk inhibitor Concomitant MEK and IGF 1R inhibition by 212 and PPP led to an in the fraction of cells in the SubG1 stage of the cell cycle, as well as an increase in the number of Annexin V good cells, suggesting that coinhibition of MEK and IGF1 R contributes to increased cancer cell death. Similar results were observed when inhibiting MEK with AZD6244 in mixture with PPP or by combined treatment with 212 and 458. The results were confirmed by us from our 2D programs by using 3D spheroid assays to determine if combined MEK and IGF 1R or MEK and PI3K inhibition can produce cytotoxicity in melanoma cells resistant to BRAF inhibitors in the context of a 3D collagen matrix. Simultaneous treatment with 212 and 458 established that BRAFV600E cells resistant to BRAF inhibitors undergo apoptosis in a reaction to combination treatment to a much greater degree than when treated with every individual element. Treatment with PPP in mixture with 212 or AZD6244 resulted in decreased Retroperitoneal lymph node dissection cell viability in 885 resistant cancer spheroids. The collective data declare that cotargeting MEK and IGF 1R/PI3K can lead to impressive antimelanoma action in melanomas resilient to BRAF inhibitors. We examined by immunohistochemistry cancer biopsies from five patients with metastatic cancer treated with the BRAF inhibitor PLX4032, to judge the possible clinical implications of our in vitro findings. The cancers of five patients were BRAFV600E and initially responded to treatment with PLX4032 but relapsed after 4?15 months, suggesting that they developed resistance to the BRAF inhibitor. Five sets of matched tumor samples were stained and analyzed for IGF 1R and pAKT senselessly with a pathologist. We found increased AG-1478 clinical trial degrees of IGF 1R and pAKT in post relapse cyst biopsies of one individual. This patient didn’t have extra Braf mutations, Nras mutations, or changes in Pten status. Patient 1 had mind and subcutaneous metastases but no other organ involvement before signing up for the study. The in-patient was amount increased from 160 mg of PLX4032 twice a to 720 mg twice a day, had a great response to the BRAF inhibitor as judged by CT scans, and had a free survival of 466 times, but relapsed on PLX4032. A developing intra abdominal lesion was not observed at presentation, but was then observed at development using PET/CT scan blend. Where improved IGF 1R expression and phosphorylation of AKT, in the lack of changes in Braf, Nras, or Pten mutation position, is associated with resistance to BRAF inhibitors, these findings are consistent with our in vitro data.
We performed genome wide gene expression profiling in MCF7 cells following treatment with triptolide and actinomycin D. The expression improvements induced by triptolide and actinomycin D were very similar, suggesting that, like actinomycin D, triptolide likely functions as a transcriptional inhibitor. Consistent with this observation, triptolide was deacetylase inhibitor recently reported to bind to XPB, a of TFIIH, and inhibit phosphorylation of the C terminal end of RNA polymerase II, which results in transcriptional inhibition. Utilising the Connectivity Map database containing expression profiles of 1,366 compounds, the triptolide activated page showed a top degree of similarity to both doxorubicin and daunorubicin. The anticancer effect of anthracyclines has long been attributed to inhibition of DNA topoisomerase II. Nevertheless, the DNA topoisomerase II inhibitor etoposide induced a transcriptional account distinct from that induced by triptolide. Taken together, these results strongly suggest that the compounds that emerged from our MCL1 repression display, including the anthracyclines, function as worldwide transcriptional Lymphatic system repressors. We consequently refer to them as transcriptional repressor substances. Amazingly, the TR materials showed remarkable preferential activity against MCL1 set alongside the remaining portion of the transcriptome. For instance, MCL1 was in the most effective 0. 05 percentile of triptolide repressed genes, and the MCL1 transcript was repressed a lot more than 5 fold within 2 hr of treatment. None of another BCL2 family genes were repressed over 2 fold, on the contrary. In line with the documented short half life of MCL1 protein, inhibition of MCL1 mRNA caused an immediate decline in MCL1 protein levels that occurred prior to poly polymerase cleavage, a gun for caspase activation. On the basis of the mechanisms suggested above, we hypothesized purchase Dinaciclib that when MCL1 repression is really a biologically relevant target of TR compounds, then these compounds should induce apoptosis in the exact same cancer cell lines. We therefore tested caspase activation and cell viability of 74 non small cell lung cancer and 33 breast cancer cell lines following treatment with actinomycin D, doxorubicin, triptolide, and flavopiridol. Flavopiridol has previously been reported to repress MCL1 expression via inhibition of CDK9. Responses to the TR substances were highly correlated when measured both by caspase activation and cell viability. As expected, cell viability was highly correlated with caspase activation for every TR ingredient, indicating that the TR compounds impair cell viability via apoptosis. By contrast, substances that destroy cells via different mechanisms, such as for instance methotrexate and etoposide, exhibited different patterns of cytotoxicity.
Dependence on MALT1 proteolytic activity for growth was examined by 50 mM Z VRPR FMK treatment for 48 hr. As expected, the two GCB DLBCL cell lines did not display evidence of MALT1 or NF kB signaling and didn’t answer Z VRPR FMK. The U2932 and HLY1 ABC DLBCL cell lines harbor mutations in TAK1 and A20, which trigger NF molecule library kB signaling downstream of MALT1. Hence, these two cell lines exhibited relatively little reaction to Z VRPR FMK. In contrast, the ABC DLBCL cells HBL 1, TMD8, OCI Ly3, and OCI Ly10 exhibited proof of MALT1 action and inhibition of growth by Z VRPR FMK, showing why these four cell lines are MALT1 dependent. All eight cell lines were exposed to increasing levels of MI 2 and cell growth was measured at 48 hr having an ATP based metabolic luminescent assay. Expansion inhibition by MI 2 was selective for MALT1dependent cell lines, while the ABC DLBCL MALT1 separate cell lines, U2932 and HLY 1, and the two GCB DLBCL cell lines were resistant. The GI50 for MI 2 in HBL 1, TMD8, OCILy3, and OCI Ly10 cells was 0. 2, 0. 5, 0. 4, and 0. 4 mM, respectively, that is below its IC50 in vitro. Gene expression This is probably explained by the irreversible binding of MI 2 to MALT1 as shown in Figure 3, but could also be due to intracellular accumulation of the substance. Indeed, we observed an to 30 fold increase in MI 2 intracellular concentration in experiments where HBL 1 cells were exposed to 0. 02, 0. 2, or 2 mMMI 2 for 2 hr and washed 3 x and MI 2 was measured by LC MS. The intracellular concentration in the 0. 2 mM MI 2 treated cells was 5 mM, similar to the calculated in vitro IC50. To determine the kinetics of accumulation of free drug, we measured the intracellular concentration of MI 2 at the GI50 concentration of 0. 2 mM at 6 and 2, 30 min, 12, 24, and 48 hr. By 12 hr, PF299804 ic50 there is virtually no detectable free MI 2 within the cells. But, after coverage of HBL 1 cells to increasing levels of a single dose of MI 2, recovery of cells just started initially to become evident after 48 hr. These data claim that the powerful biological ramifications of MI 2 are due at the very least in part to its irreversible binding to MALT1 aided by its tendency to focus in cells. To investigate in increased detail the biological effects of MALT1 inhibition, HBL 1, TMD8, OCI Ly10, and the GCB DLBCL cell line OCI Ly1 were treated with increasing concentrations of MI 2. Cell proliferation was examined utilising the 5 carboxyfluorescein diacetate succinimidyl ester dilution assay by flow cytometry on viable cells at 48, 72, and 96 hr. MI 2 considerably inhibited proliferation in HBL 1, TMD8, and OCILy10 while it didn’t affect OCI Ly1.
For the studies on values for 5 HT uptake, Western blot analysis, and sphingomyelinase activity, the outcomes were presented by means_standard error of the mean. Students natural product library t test was used to analyze the information. Statistical significance was set at pb0. 05. 3. 1. The SMase inhibitors plugged IFN induced 5 HT uptake We examined the effects of numerous inhibitors for basic SMase, or p SMase on IFN induced 5 HT uptake. Pretreatment with sph 24 and D609 for 30 min restricted IFN induced 5 HT uptake for 24 h, while these inhibitors addressed alone exerted no impact on the capability of 5 HT uptake. No significant effect was shown by myriocin, a potent inhibitor of serine palmitoyltransferase for the first step in sphingosine biosynthesis, on IFN caused 5 HT uptake. 3. 2. Curbing SMase blocked IFN induced activation of ERK and STAT As previously demonstrated, MEK inhibitor PD98059 blocks IFN induced ERK1/2 activation, which mediates 5 HT uptake. In this study, pretreatments with Sph24 and D609 for 30 min also plugged IFN stimulated quantities of phospho ERK1/2. In Cholangiocarcinoma addition, Sph24 and D609 somewhat blocked IFN induced levels of phospho STAT1 and phospho STAT3 at Ser727. Nevertheless, Sph24 blocked IFN induced levels of phospho STAT1 at Tyr701 and phospho STAT3 at Tyr705, whereas a slightly but not significantly decline was shown by D609 at these levels. 3. 3. Inhibiting COX 2 expression blocked IFN induced 5 HT uptake IFN induced COX 2 activation in a time dependent manner. Celecoxib caused a decrease in IFN induced COX 2 expression and blocked IFN induced 5 HT uptake, along with the quantities of phospho ERK. Additionally, celecoxib significantly Crizotinib structure blocked IFN stimulated levels of phosphoSTAT1 and phospho STAT3 at Ser727, while a slightly decline was shown by it at these levels of phospho STAT1 at Tyr701, and STAT3 at Tyr705. IFN induced COX 2 levels were blocked by d609 pretreatment for 30 min at 5 min. This inhibitory effect preserved to 15 min. However, sph24 did not bring about this result at 5 min and up to 60 min. 3. 5. Curbing PI3K/Akt activation plugged IFN induced ERK activation Several studies have documented that COX 2 chemical also reduces Akt activation, which mediates cell growth or inflammation. However, little is famous that the role of COX 2 induction connected to activation of Akt within an power of 5 HT uptake. Hence, we further examine effects of celecoxib on the degrees of Akt phosphorylation induced by IFN. Results showed that celecoxib restricted IFN caused phospho Akt levels at Ser473 in a dose dependent manner and time. Furthermore, the IFN induced phospho Akt degrees were blocked by way of a PI3K/akt inhibitor Wortamannin. IFN induced phosphoAkt levels were also blocked by d609 pretreatment for 30 min at 15 min. Nevertheless, sph24 didn’t bring about this inhibition, that has been much like those results seen in COX 2 term. Additionally, Wortamannin inhibited IFN induced ERK activation and 5 HT uptake.
Trypan blue exclusion had been used by the earlier report to assess cell survival 24, 48, 72 and 96h post IR. Our research used the important dye, (-)-MK 801, to gauge cell survival 10?13 times post IR. This difference can be reconciled if 1. 0 Gy of IR causes ICF cells to die more quickly than wild type cells but that similar proportions of cells survive after 10?13 times. Why did we see strong ATM s1981 signals in only the ICF cells and not mutant cell lines with other chromatin disorders One risk is that RSTS, CLS and FSHD LCLs have insufficient irregular chromatin to generate a strong response from the putative chromatin monitoring program involving ATM. Consistent with this possibility, a small but reproducible upsurge in ATM s1981 signal was observed in CLS and RSTS products, while a much more resilient signal was observed in ICF syndrome where significant pericentromeric parts present excessive heterochromatin. Another possibility is that ATMs1981 in ICF LCLs appears in a reaction to chromosomal DNA instabilities reported in ICF LCLs, in place of from the principal chromatin defects caused by DNMT3B lack. CLS and FSHD patientsmay be too secure to elicit this type of response, If that’s the case, then Cellular differentiation the genomes of the LCLs from RSTS. This description would require DNA disorders other than DSBs to generate a qualitatively different response that involves the look of ATM s1981 that is not capable of phosphorylating p53, NBS1, SMC1 or H2AX. A third possibility is that particular chromatin abnormalities are found by ATMwhile qualitatively different chromatin disorders escape this recognition. The failure of ATM s1981 to phosphorylate p53 in LCLs displaying chromatin defects unveiled that although serine 1981 phosphorylation is important for ATM kinase activity, it PFI-1 ic50 is insufficient to activate ATM kinase regarding the p53 substrate. ATM autophosphorylation involves protein phosphatase 5 exercise, the histone acetyltransferase MOF, and acetylation of ATM via the protein acetylase Tip60. All three of these proteins bind ATM. Furthermore, phosphatase 2A binds ATM and a PP2A inhibitor leads to ATM activation. In ICF LCLs or standard LCLs addressed with chloroquine, ATM s1981 may possibly occur by an alternative or improved pathway that does not involve one or more of these actions, and this form of ATM s1981 is inactive towards p53 and other downstream substrates. Yet another explanation for the failure of p53 to be phosphorylated in LCLs is that in primary fibroblasts chromatin changing agents cause p53 to be phosphorylated at serine 15 by a protein other than ATM. For instance, chromatin transforming treatments may create pressure that activates a process in which ATR phosphorylates p53 however, not NBS1, SMC1 or H2AX.
Cells possess a complex response to DNA damage that coordinates repair, cell cycle arrest PF299804 clinical trial and apoptosis. Although it can be done that 15 mutations in one protein could influence the conformation of the protein in a low specific method, these results could mean that phosphorylation of one or even more of these sites, several of which were proved to be phosphorylated after DNA damage in this study, are essential for 53BP1 function. Cells are constantly subject to extrinsic and intrinsic factors that creates mutations in DNA. Double strand DNA breaks are specially dangerous to the cell and may result in deadly or oncogenic improvements to the cellular genome. The reaction to DSBs requires activation of the PIKK family serine/threonine kinase Ataxia Telengiectasia Mutated and phosphorylation of a significant number of downstream transducers and effectors. ATM lies at the nexus of the DNA damage response and a detailed understanding of its functions and regulation are essential to a understanding of as the route. Increased comprehension of this path Papillary thyroid cancer holds promise for treatment and far better diagnosis of cancer. Trans phosphorylation may be involved by the molecular mechanism by which ATM becomes active upon generation of DNA double strand breaks on S1981. Nevertheless, the actual way ATM is activated remains uncertain. Existing techniques for finding the exercise and activation of ATM phosphorylation are limited in both spatial resolution or temporal resolution. It is also uncertain how consistently the experience of ATM could be assessed by monitoring the phosphorylation state of S1981. Consequently, improved methods that may observe the kinase activity of ATM could be useful to further our comprehension of the activation and downstream signaling of ATM. chemical library screening Much promise exists for practices that assay signaling events in individual living cells instantly. This really is specially therefore for the DNA damage response, that is extremely dynamic, and involves delightful spatial compartmentation in nuclear damage foci and also pan nuclear and cellular responses. Revolutionary studies of the spatiotemporal dynamics of the localization of proteins active in the DNA damage response have provided useful information of the dynamics of recruitment of proteins to damage foci. Nonetheless, it’d be useful to achieve amore step by step picture of the massage tiotemporal dynamics of the phosphorylation based signaling active in the DNA damage response. Protein phosphorylation has been monitored in living cells using fluorescent reporter proteins. A variety of kinases have been successfully studied using unimolecular CFP YFP based journalists where a substrate and phosphobinding domain are used to create an intramolecular change in FRET and evidence efficiency. Here we present ATOMIC, a based reporter for checking the kinase activity of ATM in individual living cells in real time.
Dulbeccos Modified Eagle Medium, penicillin/streptomycin and hygromycin B were from Gibco Invitrogen, foetal calf serum was from PAA and bovine serum albumin was from Serva. Lysis stream components HEPES, EDTA, glycerol, Triton X 100, Na4P2O7 and Na3VO4 were from Sigma?Aldrich and NaF was from Fluka. Letrozole solubility Complete Mini protease inhibitor cocktail tablets were from Roche Diagnostics. Trypan blue stain, NuPAGE? 4?12% Bis Tris Fits in, NuPAGE? LDS sample barrier, NuPAGE? MOPS working buffer and nitrocellulose membranes were from InvitrogenTM life technologies. Bisbenzimide, 3 2,5 diphenyltetrazolium bromide, ammonium pyrrolidine dithiocarbamate, crystal violet and Triton X 100 were from Sigma?Aldrich. Carboxy H2DCFDA carboxy 2_,7_ dichlorodihydrofluorescein diacetate) was from Gibco Invitrogen. Staurosporine and the ATM kinase inhibitor were from Calbiochem. BCATM Protein Assay Kit Cellular differentiation and Tremendous Transmission West Pico Chemiluminescent substrate were from Pierce Biotechnology, Inc. . ImmobilonTM European Chemiluminescent HRP Substrate was from Millipore Corporation. H2O2 was from Herba Chemosan ; colcemid was from Irvine Scientific. All the substances were from Roth or Sigma?Aldrich. The following key antibodies were used: polyclonal rabbit phospho ATM antibody ; sequence certain polyclonal rabbit anti ATM antibodies raised against synthetic peptides corresponding to amino acids 819?844 or 2550?2600 of human ATM; polyclonal rabbit anti caspase 3 antibody, polyclonal anti _ tubulin ; polyclonal phospho histone H2AX antibody ; rabbit monoclonal anti p21 Waf1/Cip1 antibody, monoclonal anti _ actin antibody ; monoclonal anti Poly polymerase antibody. These secondary antibodies were used: HRP conjugated goat anti mouse IgG and HRP conjugated goat anti rabbit IgG. WI 38 VA13 is really a SV 40 immortalized fibroblast cell line. AT22IJE T is an ATM bad SV40 immortalized purchase Bicalutamide fibroblast cell line, originally established from key A T fibroblasts. VA13 and AT22 cells were grown in DMEM with 1 g/l sugar, 4 mM m glutamine, 110 mg/l sodium pyruvate and 25 mM HEPES, supplemented with 5% FCS and 100 U/ml penicillin/streptomycin. Human EA. hy926 endothelial cells were grown in DMEM with 4. 5 g/l sugar, 3. 97 mM m 1 mM and glutamine sodium pyruvate supplemented with ten percent FCS, fortnight penicillin streptomycin and 1?? HAT supplement. All three cell lines were cultured at 37 C in a humidified atmosphere of five full minutes CO2 and 37 C LDL was isolated by ultracentrifugation from fresh human plasma, obtained from healthier volunteers. LDL was kept at 4 C and sterile filtered. Ahead of oxidation, LDL was dialyzed over night against PBS at 4 C. Oxidation of 500 _g/ml LDL was performed with your final concentration of 30 _M Cu2SO4 for 18 h. EDTA terminated the response, the samples were saturated with N2 and stored at 4 C. As described depiction of oxLDL was done.
Pretreatment of cells with the ATM chemical, KU 55933, properly blocked DDR, but did not affect DNA injury amount measured by the FADU process. In a paper describing KU 55933 it was found as measured by the clonogenicity assay that the ATM inhibitor sensitized HeLa cells to the cytotoxic PFI1 aftereffects of etoposide. We show surprisingly, that KU 55933 protects T cells against apoptosis suggesting its opposite action on normal resting cells and on proliferating cancer ones. Human T cells were isolated from buffy coats of blood samples obtained from informed healthier volunteer donors, prior to local ethical rules, and given by Domestic Blood Center, Warsaw, Poland. Isolation was done utilising the RosetteSep Human T Cell Isolation Cocktail, in line with the manufacturers instruction. The cell love was usually more than 95%. Cells were seeded at a density of 1 1640 medium supplemented with one hundred thousand FBS, 2 mM l glutamine and antibiotics and kept in humidified atmosphere. Jurkat E6. 1 cells received from ECACC were cultured in Metastasis RPMI 1640 medium supplemented with 10% FBS, 2 mM m glutamine and antibiotics and held in humidified atmosphere. The cells were seeded 24 h before therapy at a of 4?? 105 cells/ml. Etoposide and KU 55933 were dissolved in DMSO and included with the choice to a given final concentration. KU 55933 was put into the medium for just two h before etoposide without medium change. The DMSO concentration in cell culture didn’t exceed 0. 10 percent, which did not affect cell survival. Recognition of newly synthesized RNA was calculated utilising the Click iT? RNA HCS Assays. T cells were treated with transcription inhibitors sometimes 10 _M _ amanitin for 17 h or 40 _M 1 _ d ribofuranoside for 1 h before the addition of 1 mM 5 ethynyl (-)-MK 801 uridine for 1 h at 37 C. After ward cells were fixed with 3. Seven days formaldehyde in PBS for 15 min and permeabilized with 0. 5% Triton X 100 in PBS for 15 min. EU increase was detected utilising the Click iT? Effect mixture containing green fluorescent Alexa Fluor? 488 azide. After the washing action, mean fluorescence of cells was measured using FACSCalibur and CellQuestPro computer software. Externalization of phosphatidylserine to the outer layer of cell membrane was evaluated by binding of Annexin V in the current presence of 7 AAD, dead cells were stained by a dye. The assay was performed using the PE Annexin V Apoptosis Detection Kit I. Cells were washed, stopped in the Annexin V binding buffer and stained with PE conjugated with Annexin V and 7 AAD for 15 min at RT. Flow cytometric analyses were performed using FACSCalibur and the CellQuestPro analysis pc software.


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Immigrant Rights News - Tuesday, July 07, 2009
1. TruthOut: Criminals because we worked
3. New York Times: Piecing Together an Immigrant’s Life the U.S. Refused to See
Criminals because we worked
Saturday 20 June 2009
Complaining also had a price, however. "I was reluctant to say anything because of my need," she says. "I have four children. So I preferred to stay hurt, and take pills for it, than to go out on disability." Finally, though, it got too much. She couldn't sleep without pain constantly waking her, and she was moving through a haze of exhaustion. So, she went to the company doctor.
"He said my nerves were inflamed, and sent me to therapy," she recalls. "I know I have repetitive stress syndrome, but I asked him not to put me on restricted duty, because I knew the company would just send me home. There is no easy work in production. But he put me on restrictions anyway, and that's what happened. It didn't change anything, and eventually I had to go back to my job. It still hurts to work."
It might seem hard to understand that a job like this is worth trying to keep. But being out of work is worse. So every day, Agustiano and 253 others are out in front of Overhill Farms' two plants on East Vernon Avenue, in an industrial enclave in southeast Los Angeles, trying to fight their way back onto those speeding production lines.
The company says Agustiano's Social Security number is no good. That accusation, and the mass firings based on it, has put these 254 workers, mostly women, at the epicenter of the national debate over the nation's immigration laws. Overhill Farms and the advocates of immigration enforcement in the workplace claim the workers shouldn't be at work at all. Hiring people without legal immigration status is a crime, they say, and those suspected of the lack of such status should be fired. […]
Hispanic males are now majority in county jails
by JJ Hensley - Jul. 7, 2009 12:00 AM
There's a shift under way in the
The population of White male inmates, after growing steadily for more than a decade, has dropped in the past five years, while the population of Hispanic male inmates has increased to the point that they make up the ethnic majority, according Sheriff's Office data.
Experts say the explanation for the increase is largely due to overall population trends coupled with a series of recent laws and policy decisions targeting illegal immigrants.
The majority of Hispanics in county jails are not in the country illegally. However, most of the illegal immigrants jailed as a result of immigration-enforcement efforts are Latino. […]
New York Times
Piecing Together an Immigrant?s Life the
By: Nina Bernstein
July 5, 2009
When the 43-year-old man died in a
In March, more than three years after the death, federal immigration authorities acknowledged that they had overlooked it, and added a name, "Ahmad, Tanveer," to their list of fatalities in custody.
Even as the man's death was retrieved from official oblivion, however, his life remained a mystery, The New York Times reported in an April article on the case that pointed up the secrecy and lack of accountability in the nation's ballooning immigration detention system. Just who the man was and why he had been detained were unknown. […]
the end / el fin / tamat <><><>


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Wednesday, June 1, at 9: All tournaments are ranked by both world amateur rankings systems: If you do not have an access code, please visit the to request an invitation. Way to go ladies!!! All tournaments are ranked by the World Amateur Golf Rankings WAGR and Scratch Players Rankings systems for maximum amateur exposure. The tour provides players elite golf courses and several incredible resort stay opportunities for the entire family at affordable pricing exclusively to Texas Collegiate Amateur Tour members. Patricia Walters Meyer St.
Now how can we please each other? Membership is good through Remember if you sign up to play in the 4 Ball then you are automatically registered in the tournament. Pornhub is the most complete and revolutionary porn tube site.
The remaining players will be flighted into seven flights of eight based on handicap indexes. Club Representatives will be emailed an entry card also. The 32 players with the lowest qualifying scores will fill the championship flight and contend for the championship title. Low 96 Handicap Index entries. Isabella Fierro, Mexico [3 and 1] Semifinals — def. Schubert is the second Texas golfer on the team to have won a USGA Championship.

domain: hobby


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I am so disappointed in this book. I had it on my wish list FOREVER and almost bought it on eBay because I wanted to read it so badly. Now after finding it at a neighboring library I am upset it took me so long to plod through it that I ended up returning it late and it cost me a dollar! (waste) I have a compulsion to read a book after I start it even when it is hard to do so. I had to make myself read this!
So unrealistic! The book description makes it sound like she has a celebrity crush on him which is untrue. She is so deeply religious imagining a kiss between them sends her into delusions of going to hell. (I have no problem with religion just didn't like the shove it down your throat/ holy lifestyle way of writing) The beginning set up is somewhat realistic as far as bumping into each other a few times (coincidence) but from there goes downhill fast. The "witty bantor" between the two literally makes you wince and is completely stupid. You have to wonder what kind of weirdo the celebrity is to seek out such a religious, dumpy, boring woman for a friend. Her husband is the only one with any sense in the whole book but is a very quiet boring character as well.
The ending is beyond terrible and I had to read the last few pages again to understand what actually transpired.
Save your self the wait and find another better reviewed book to enjoy!
Have to admit I was extremely uncomfortable reading this book. At times I loved it - the author's writing style was great. But mostly I didn't like it at all. The premise just didn't work for me. And by the end of the book, I wanted to throw it across the room!
The age-old question of whether a man and a woman can just be friends gets a deliciously whimsical twist in Shannon Hales second novel. In a follow-up to Austenland, this fantasy what-if story asks: what if hes Felix Callahan, handsome British actor with a French supermodel wife? What if shes Becky Jack, happily married Mormon housewife, mother of four, and a fan of Felixs work? Such title characters usually dont meet in real life, but when Shannon Hale asks for this suspension of disbelief, she delivers a beautiful, poignant story of love and friendship in return.
The blurb might lead you to believe it will be an escapist housewife meets her celebrity crush storyline. Instead, the fact that Felix and Becky strike up an instant friendship is as believable as the easy dialogue between them is witty. Beckys character resembles her famous zucchini bread good and wholesome, but with spunk and fiber and holds the story together. You dont begrudge that she was the lucky one who got to meet and become best mates with a celebrity heartthrob instead of yourself because you can see what about Becky captured Felixs liver (they refer to each other as such since their respective spouses represent their hearts). Rather, you grow to care about Becky and her family as she and husband Mike wrestle with the question of whether a platonic mixed gender friendship is possible.
Indeed the story progresses so seamlessly that you might not even notice the time pass as the Jack children grow up and the Becky-Felix friendship is tested by trials to both partners. Theres a lot of fun and tears along the way, but without revealing the answer to the original question, let me just say the story affirms the readers awe in the power of soul mates. Although Shannon Hale might want to establish herself as excellent author of fantasy chick lit, she does so through her talent in writing about grounded characters just authentically living life in The Actor and the Housewife.
I really agree with the other reviewer of this book. The idea is great - who wouldn't want to meet your movie star crush and hit it off? But I didn't find the whole thing very believable. There were some funny conversations between the two, but a lot of the time the banter was annoying and so far out there that it would really happen, especially when they have absolutely nothing in common. The second half of the book is so much better and by the end, you really want it to turn out differently than it was written. I don't want to give too much away to those who haven't read it yet, but I liked how he provided her with support when she needed it, not only emotionally but the way he stepped up and paid for things without her even realizing, etc., and by backing off and letting her be until she came to grips with things on her own. That is a true friend. Again, mixed feelings but guess I'm glad I did read it.
Shannon Hale is a great writer, but she's using her talent for evil with this book. This book will take you on an emotional roller coaster, and personally I did not enjoy it. I couldn't put it down in most places, it made me sob, it made me laugh, it made me depressed. And after all that, after investing completely in the characters to the point of extreme and possibly insane empathy, the ending was not cathartic at all. (I realize we usually complain about the "predictable" outcome, but in this case it would have been a relief.)
Despite it's ridiculous fantasy of a plot (please: the actor and the housewife? it gets better: he's basically Brad Pitt or Tom Cruise and she's a Mormon from Utah), this book takes the most painful of all "realistic" outcomes (the type that, yes, we all experience from time to time but optimistically hope will not become the norm) and makes you feel like even in your movie star fantasies you can't escape from them. Fun!
But take my sarcasm with a grain of salt and as the warning I intend it to be. If you enjoy Hale and are braver than me about books that toy with your emotions and refuse to give you a predictable ending, definitely give this a try. It is well-written and unique.
I was shocked to read how many people didn't enjoy this book. I absolutely loved it! Who doesn't have a celebrity crush you'd love to meet and strike up a close friendship with? I'm happily married, so friendship would be enough for me. This was hard for me to put down. Even when I wasn't reading it, I was thinking about the characters. I am not a romances reader AT ALL, mostly mystery, so this was a little out of my lane but , I thoroughly enjoyed it.
Your film star crush bumps into you and you just happen to instantly hit it off and decide that you're soul mates? Really? The premise of this book is wildly unrealistic and so when I read it I was having problems suspending my disbelief enough to really get into it. But the focus of the book shifts away from this in the second half of the book about becomes something else entirely, a story about one woman's emotional life and the journey that two friends take together through it. The story takes place over ten years or so, which gives the author time to describe the natural ebbs and flows in a friendship as people's needs for each other change.
The main problem with this book is that it doesn't know whether it wants to be a light and fluffy comedy, which it is in the first half, or a deeper more emotional story about love, loss and the power of friendship, which it is in the second half.
The first half of the book is nothing special, and I found the film star plot line distracting and could have done without it altogether. But it's an easy read and worth getting through to get to the rest. I liked the second half much better, and there was real emotional power and resonance in the author's treatment of the impact that true friends can have on each other.
I love Shannon Hale's fantasies, but this book didn't really work for me, especially in the first half. The descriptions of the movie industry and the characters who were part of that world gave me the feeling the author wasn't writing about what she knew, but was instead relying on stock stereotypes. The editing was also uneven.
That said, the idea of the story was interesting, and I liked many of the Utah characters, especially Mike. The battle with cancer was poignant and the section where Becky was being wooed was very nice.
Yes, this story is unbelievable but it is so hilarious! I loved every minute of reading it and read it in one sitting. You just need to suspend your 'reality button' for it and you'll find you love it!


Associate Professor of Voice, Shenandoah Conservatory Artistic Director of the CCM Vocal Pedagogy Institute
If you don’t already know Sheri Sanders, she is the incredible creator of “Rock the Audition.” I met her when her book “Rock the Audition” first came out and have enjoyed watching her career skyrocket ever since.
Sheri teamed up with MusicNotes.com a few years ago to begin offering cuts for pop/rock musical theatre auditions. What really makes these cuts special is that the accompaniment is designed specifically for an audition room setting. There is no doubling of the voice, only a solid groove underneath that supports the singer. There are now 500 songs available for download and another 500 on the way.
You can also follow Sheri on Spotify (Sheri Sanders) and check out 36 playlists she has put together to help performers get a better feel for each genre and maybe find a few new songs. This is a game changer for pop/rock auditions and a huge help for all of our musical theatre students. Thank Sheri!


The great news for MAC users is that they can now download Twitter for MAC. It’s not that Twitter was never available for MAC because all the MAC users enjoyed the amazing features of Twitter for a long time.
In fact, Twitter for MAC had similar features like Twitter for iPhone. The reason why Twitter app disappeared from the MAC store is that Twitter focused on mobile apps for a long time. Thus, the Twitter app for MAC was neglected for a long time. As a result, it disappeared from the app store as it wasn’t compatible with the latest version of iOS.
Apple announced Project Catalyst for macOS 10.15 Catalina, which makes it easy for developers to bring their iPad projects to macOS as native Mac apps. We are excited that Project Catalyst will enable us to bring Twitter back to the Mac by leveraging our existing iOS codebase. We’ll also be able to add native Mac features on top of our existing iPad experience, while keeping our maintenance efficient as we continue to improve this shared codebase in the years to come.
However, the developers have now put in all the efforts to make this app available for the MAC users. Fortunately, they’ve successfully launched Twitter for MAC with their endless efforts.
Table of Contents
What you can expect in the new Twitter for MAC?
In the past, Twitter for MAC app was built with a separate codebase. But the developers have now attached it to the existing iOS codebase. The reason why they’ve made these changes is that they are trying to increase their clients. The advanced Twitter app is not only useful for the users but it will bring a lot of benefits for developers as well.
That’s just because the developers won’t have to change the code whenever a new version of Twitter for MAC is launched. The best thing about this latest app is that it won’t cover a lot of space on your device. Moreover, it will load faster than the previous app.
Things you should know about new Twitter for Mac
Many people don’t know but a huge number of Twitter users are the regular users of MAC. And it was quite painful for them that they couldn’t use their favourite app for months. However, the new app is equipped with several amazing features. With the latest app, you can enjoy resizable windows with dynamic content, native notifications, multiple windows support, keyboard and drag & drop support. There are plenty of other features you can enjoy with the new Twitter for Mac.
How to use Twitter for Mac?
If you haven’t used Twitter on your MAC device in the past, you shouldn’t be worried about using it. This new app comes with a user-friendly interface and you won’t face any problems with understanding different features of the app. After installing the app, you’d have to create a new account by tapping the Sign up button. And if you already have an account, you can use your credentials to sign in to the account.
You’d then be directed to a page where you can see tweets from your followers. Here you can tap the tweet icon to post a tweet or go to the notifications tab to take a look at the recent notifications.
What to expect in future?
The developers are now trying to build the Twitter Lite for MAC so that the users can now save their data while enjoying several features of the app. Similarly, they are making some efforts to make their app more efficient.
To learn more about Twitter for Mac and other OS, you can just read more about it from our other blogs related to Twitter by clicking here.


Please note that Calderdale Council Services will be mostly unavailable during this day.
There may be other service disruptions elsewhere, please consult with appropriate organisations.
Customer First – closed
Contact Centre – closed
Crematorium – open, the office will be closed, but the phone line will be open
Libraries – closed
Markets – closed
Museums – closed
Register Office – closed
The Shay – closed
Sport Centres – closed
Victoria Theatre – box office and theatre will be closed
Waste and Recycling – refuse, recycling and garden waste are cancelled, Refuse waste scheduled for Monday 19 Sept will be collected on Tuesday 20 September and collections for these services will run a day late during this week.
Recycling collections scheduled for Monday 19 September will not be re-scheduled. Please return containers to their storage point, crews will collect Monday’s recycling on Monday 26 September. Recycling collections from Tuesday 20th will be to the current schedule.
Household waste recycling centres – closed
Halifax Minster will hold a Service of Commemoration for HM Queen Elizabeth II at
7pm on Saturday 17th September
with the Lord Lieutenant, Ed Anderson CBE.
This service is jointly hosted by the Mayor of Calderdale and The Vicar of Halifax, Revd Canon Hilary Barber.
The Minster has seen a steady stream of mourners for the Queen since Friday, lighting candles and laying flowers.
You are welcome to join this service where we pay our respects to the Queen and remember her many years of dedication and service to her role.
Unit 3 Causey Hall, Dispensary Walk, Halifax, West Yorkshire, HX1 1QR
T: 01422 355436
Halifax Minster, on behalf of the whole Calderdale community, is organising a service to commemorate the second anniversary of the Covid pandemic and the start of lockdown. The service will be the opportunity to remember the 459 residents of Calderdale who have died due to Covid and to give thanks for the hard work of all the keyworkers of Calderdale during the past two years to help maintain community life.
At the service a candle will be lit for each person who has died and an artwork installation to remember all those affected by the pandemic will be on display for the first time. The artwork, made up of the thousands of prayer cards and messages hung on our Remembrance Trees over the past 2 years, will be hung in the Minster’s tower in front of the West Window where it can be seen from inside and out. It will be floodlit with the colours of the rainbow to represent the hope shown by communities during the difficult times of the pandemic.
You would be most welcome to join us at the service on Sunday March 20th at 4pm . Please feel free to pass on this invitation to others who may wish to attend.
With every good wish
Remembrance Sunday events are commencing again this year. There will be full parade through Halifax, followed by a memorial service at the Cenotaph near Halifax Minster.
The parade starts at Halifax Town Hall from 10am on Sunday 14 November. The parade will march via Princess Street, Southgate, Horton Street, Square Road and King Street, before assembling at the Cenotaph near Halifax Minster at around 10.40am.
The Cenotaph service will start at 10.45am, including a two-minute silence at 11am. A further service of Remembrance will then take place inside the Minster.


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For the 3 months to the end of February 2005, the average level of pay settlements reported by manufacturing companies was 2.7%, the same as the figure for the previous 3 month period to the end of January. These latest figures include more than 350 settlements for January alone, the key settlement month in the year for manufacturers, which also averaged 2.7%.
During this period, the number of manufacturers reporting that they had frozen pay fell slightly to 6% from last month’s revised figure of 7%. However, the number of manufacturing companies reporting that they had deferred their pay settlement remained constant at around 4.5%.
Commenting on these latest figures, EEF Deputy Director of Employment Policy, David Yeandle, said:
“The continuing low level of settlements during a key period of the year for pay negotiations in manufacturing demonstrates that there are no wage inflationary pressures coming from this sector.”
Settlement level - per cent
Number of settlements
Zero (pay freeze)
55 ( 27 settlements at 2 per cent exactly)
238 ( 122 at 3 per cent exactly)
98 ( 14 at 4 per cent exactly)
4.00 or more
The March 2005 Pay Bulletin analyses 434 settlements affecting 56,875 employees in the 3 months to the end of February 2005. Of these, the average settlement was 2.4% in December 2004, 2.7% in January 2005 and 2.6% in February 2005 although the figures for both December and February were based on a relatively small sample of settlements. These figures may be liable for revision to take into account settlements for this period that have not yet been received.

domain: finance