To identify the ideal Cellular Analyser for your application we have developed the Cellular Analyser Selector Tool which is a configurable filter to narrow down the results to match your exact requirements.
The SNYPER family of signal analysers are sophisticated yet easy to use with a large and bright, full colour display. The range is offered in both 2G / 3G / LTE and 2G / LTE Cat M / LTE Cat NBIoT cellular technologies to cover all network cell towers in use today. The SNYPER is a hand held, battery operated unit and can operate for several hours between charges (depending on use). It analyses all cellular signals from any network at any particular site being surveyed and displays the results in a simple and easy to understand format.
The SNYPER also provides a summary of all the networks found in the area, their relative signal strengths and number of cells available. This information allows you to very quickly make a decision about the best network to use for your application in the area and to determine what options you have with regards to secondary backup networks. As a result this is an invaluable tool for performing site surveys and determine the best mobile network to use for your system.
The SNYPER family also performs a number of different functions to determine:
- Optimum antenna placement
- Best network performance for a site
- Evaluate performance of existing installations
- Best choice of network operator for a site
- Rank network signal strengths in order
The SNYPER has a number of signal strength thresholds within the summary page, providing a more concise view where only signals above a certain dBm / RSSI / Percentage level are of interest.
SNYPER Application Example
The SNYPER Spectrum offers all of the features for the standard SNYPER but also offers a USB mass storage device which allows you to save up to 50 full network surveys directly on to the unit. This feature allows you to perform and store multiple site surveys and is an invaluable tool for maintenance engineers and system installers when in the field. They do not want to return to base to download survey results and the save feature allows engineers to save multiple results and remain out in the field all day long going from site to site and performing multiple surveys.
The USB mass storage device acts as a standard hard drive when plugged in to a PC and the saved results can be downloaded simply and easily using Windows, MAC or Linux. Results are available as comma separated variables (CSV) and standard web page results (HTML).
The SNYPER Spectrum also offers the LiveSCAN feature. This allows you to perform a standard network survey and then perform a real time LiveSCAN of your chosen network to determine the highest signal strength in your location by moving around the site and observing the signal strength. Using the LiveSCAN directional antenna it is possible to locate the position of your network base stations in the area.
The SNYPER Graphyte offers all of the features of the SNYPER Spectrum but in addition the unit can be left to conduct sequential surveys in a fixed location and automatically saving them. Four types of survey can be performed: a “FULL” survey (4G, 3G and 2G combined), 4G/LTE only, 3G/UMTS only & 2G/GSM only.
SNYPER-LTE Graphyte can save multiple surveys each with different logging options and all survey results can be downloaded to a PC and displayed in a HTML graphical format to clearly show the logged detail over the survey session. This can identify unreliable base-stations & intermittent cellular service which is not possible with spot surveys. The full breakdown for the HTML summary graphs are displayed in corresponding CSV files (Summary and full detail files).
Common application areas include:
- SIM free network survey for all cellular networks
- SNYPER-LTE Supports 2G / GPRS, 3G / UMTS and 4G / LTE
- SNYPER-LTEM Supports 2G / GPRS, LTE Cat M and LTE Cat NB IoT
- Summary feature displaying all available networks and cells simultaneously
- Handheld ergonomic unit with long life rechargeable battery
- Large, bright full colour LCD screen for ultra clear display
- Supplied with ‘hard’ carrying case including PSU
- Perform site survey to determine highest signal strength
- Real time LiveSCAN feature to determine basestation position
- Automatic network scanning process
- 4MB internal storage to record up to 50 network surveys
- Download survey results via USB mass storage device
- Compatible with Windows, MAC OS and Linux
- Simple menu driven interface to select options
- Battery charge status indication on screen
- Powerful ARM processor delivers fast results
- Graphical colour display simplifies readings
- Determine the best network to use for your application
- Perform real time LiveSCAN to determine the optimum location for your application
- Evaluate the performance of your existing equipment in the field
- Modify your application and tune the system to improve performance and reduce downtime
- Improve reliability and performance of existing equipment in the field
- Reduce downtime by selecting the most available network in the area ensuring good signal coverage
- Increase network download speed and network response times
- Improve battery life and system up time by reducing power output
- Cost savings and improvements in efficiency by reducing costly engineer call outs
- Improve performance for maintenance engineers storing multiple surveys without return to base
- Due to the simplicity of the SNYPER interface we have many customers using the SNYPER family to report on signal strength in dBm, RSSI and signal percentage in one easy to use summary screen
- The plug-and-play SIM free design means that the unit works out of the box with no SIM contract or data services being required to evaluate the network performance in the area.
- Improvements in overall system performance increase revenues and reduce system downtime which provides better service to end customers and a more reliable service offering


text:
Dating china head dolls
George Borgfeldt, importer USA, our Pet China head dolls ; Agnes, Bertha, Daisy, Dorothy, Edith, Ethel, Florence, Helen, Mabel, Marion made by Closter. China head dolls were sometimes sold with their own wardrobe, often a trousseau, as described in a video by Theriaults, the doll auction house.
Dating Dolls Dating a china head doll takes research and experience, although there are a couple things that can help clue you in to the date of the doll. Was she made to resemble a famous person, like Queen Victoria? Body - Is the doll's body intact? For example, one particularly interesting china doll was Frozen Charlotte, which was a one-piece doll of china - head, limbs, and body.dating china head dolls Orsini Carlos Ottolini 1950s P Palitoy Dolly Darlings Papier Mache Doll Menu 1760 Paris Doll Corporation 1940s-1956 Patsy Look a Like dolls 1928 Pedigree Sindy 1963 Ronnaug Petterssen dolls 1930s-1970s Pintel et Godchaux Maggie Bessie Pfhol cloth dolls 1897 Plastic Molded Arts s Porcelain Collector. Famous for porcelain, their work was always hand painted, and exquisitely modeled. It's called " china " because that is where the pottery originated. Whether you purchase high-end, museum-quality examples, or you delight in a doll which survived some dings and chips, collecting china head dolls means entering in a world of history, fashion and fairytales. A, a H dolls s, aich, Menzel, aBC Toy dolls 1930s-1950s, acme Toy Company s, advance Doll Toy Co 1950s, advertising.
European and American factories molded dolls with popular hairstyles, pretty faces and delicate hands. Is it made from modern materials? What Is a, china, head, doll?They could be very tiny (about the size of a modern penny a few inches tall, or more rarely, 10" or more: the name came from a folk song about a girl who didn't dress warmly enough on a sleigh ride and froze to death. The Dolly Madison doll was popular two generations after the real Dolly was First Lady. Antique China Dolls Collectors Weekly, are they contemporary with the doll?
Dating China Head Dolls, What Is A China Head Doll?
The Thuringia area in Germany had many other small porcelain factories that produced China head dolls as well. Dolly Madison hairstyles were prominent on 1870s dolls. They are rare because of dating china head dolls the clothing, and its condition.
Antique, china dolls were made by various, mostly German companies from 1836 to the 1940s. Do not remove or destroy any clothing from a china head doll, no matter how poor the condition: Just a few well-known china head doll manufacturers among the dozens who produced them included: History Anique China Doll China dolls first began to appear in the. China dolls first began to appear in the 18th century notes the 2001. The time period became associated chouette dor 420 dating this style of doll and many dealers use the term to refer to these wigged dolls from the previously mentioned dates.Features - Does the doll have interesting features, unusual hair (molded or real)? Henri Alexandre, all Bisque, dolls 1860, allied Grand Doll Mfg Co s, alma cloth dolls, alt, Beck Gottschalck. China 's German, conta Boehme doll marks V37, IX36, arm on a shield German. Condition of the head - Chipped paint, cracked china, and missing details all contribute to lowering a doll's value. They could be very tiny about the size of a modern pennya few inches tall, or more rarely, 10" or more: Dolls such as these often have a provenance, or history, of their ownership, which helps identify the period and style of the doll.
China head dolls (unglazed porcelain dolls are referred to as Parian dolls ) are usually found on a wood, cloth or kid body with some dolls having partial, china limbs as well. Related Articles, history, anique, china, doll. Clothing - Are the clothes in good condition or even present?Antique Child offers an ever-changing selection. European and American factories molded dolls with popular hairstyles, pretty faces and delicate hands. They had varied looks. The Doll Works lists many china head dolls, as well as other antique dolls.
Dating china head dolls - HolidayDating
The time period became associated with this style of doll and many dealers use the term to refer to these wigged dolls dating china head dolls from the previously mentioned dates. 1917 other doll names; Louise Brongn, Junon, La Brgre de Trianon, Marquisette, Saint Franois Samson Smith doll mark SS intertwined LTD England UK Strasburger, Pfeiffer. doll mark Patent Appd For Germany.
Dating a china head dating china head dolls doll takes research and experience, although there are a couple things that can help clue you in to the date of the doll. The doll had a head full of curls, and sometimes a ribbon, which was a popular style with Dolly Madison who lived in the early 19th century.As china manufacturing methods became more dependable, china head dolls started to fully enter the market by the 1830s according to Collectors Weekly. Determining Value Several factors enter into what makes a china head doll rare or valuable. Other factories were sold and resold, changing their names and their marks, but still making dolls and doll parts.
|Published:||20 Nov 2018, 02:49|

domain: history


ALBANY — Albany Molecular Research Inc. is cutting jobs at its U.S. operations, but where those reductions will occur and how soon weren't clear Friday, a day after the contract research and development company disclosed the restructuring.
AMRI has been struggling in recent months, although it has made some progress in reducing costs and narrowed its third-quarter loss to $5.9 million from $9.9 million a year earlier.
The announcement of additional job cuts — it trimmed 20 jobs in the Capital Region last March — came at the end of the day on Thursday. Calls to AMRI officials on Thursday and Friday weren't returned.
At least some of the layoffs may have come at the company's Burlington, Mass., plant, where one employee said a number of employees had left within the past year.
The company said in its third quarter earnings report that it was ending internal research and development activities, although it didn't say how many employees might be involved in those actions.
It also is terminating the lease at one of its plants, AMRI said.
The moves will save $10 million to $11 million a year. AMRI said it would take a $5 million to $6 million charge in the fourth quarter related to the costs of terminating the lease and employee severance costs.
Shares (Nasdaq: AMRI) fell 8 cents Friday to close at $2.77.


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domain: finance


text:
Taken together, as a part of a daily health regimen, you’ll enjoy a wide range of health benefits. These result from the intake of powerful ingredients containing numerous highly potent nutrients.
But, if you want to just choose one, you may prefer the multivitamin that benefits certain bodily systems or aspects of your health more than the other.
For starters, if you choose to avoid animal products, Super Greens is your clear choice for a multivitamin — as it is completely vegan.
Otherwise, you may find it helpful to make a decision between the two, based on your lifestyle.
Because it contains an abundance of green foods, Super Greens is highly beneficial to individuals whose diets are lacking in chlorophyll and antioxidants. The ingredients within Super Greens also serve as superior detoxifiers — excellent for individuals living in cities or working in environmentally toxic environments.
Active individuals may also find Super Greens to be more beneficial for them, as its ingredients work to replenish the body’s electrolytes — ideal for those who often perspire (or cope with kidney issues).
Whole Food, on the other hand, contains more complete proteins — highly beneficial for those whose diets are low in protein.
Whole Food‘s ingredient list also comprises simpler foods that are easy for the body to break down, meaning it may prove to be a bit gentler on those with digestive sensitivities (such as children and the elderly).
Along the same lines, the bonemeal within Whole Food is especially helpful for those with musculoskeletal concerns — such as those experiencing bone loss as they age.

domain: medical


text:
Rainbow Dash moaned quietly as she awoke, groggily opening her eyes before flinching to the bright sunlight assaulting her vision. Despite the night of heavy drinking she was no longer intoxicated, on the contrary she was completely sober and free from pain. "I guess you won AJ." The blue mare managed to say during a yawn before her vision came into focus. The sight was mesmerising yet somehow familiar, a bright sea of fluffy clouds dominated her view several of which were fashioned into columns and paths, even buildings. "AJ? Pinkie?" Rainbow struggled to her hooves with caution, noticing she was standing on the cloud sky herself. But as she stood there she felt the soft floor support all her weight, something that she seemed to already know despite never being off the ground before.
Rainbow slowly trotted across the cushioned floor, each step leaving a soothing touch on her hooves. She gazed down over the edge of her cloud, far below her she saw what looked like another less extravagant collection of clouds covering the distant land. Straining her eyes she could just make out the port town, what must have been hundreds or thousands of meters below her. "Is that, Mareina? Where am I?"
"Welcome dear pegasus." The surprised mare quickly turned around to face the approaching figure, her hooves delicately trotted across the silencing floor leaving her approach only identifiable by her calming voice and alluring perfumed aroma. "What is you name dear?" The unicorn's coat glowed with a brilliant white, almost more pure than even the clouds themselves. Her comforting sapphire eyes gazed into the newcomer's own with care and compassion.
"Hey, I'm Rainbow Dash, some just call me Dash though." Rainbow looked around cautiously, still unaware of where she was or what was happening. "Where am I? And who are you? And how did I get here?" She stated, almost demanding to be answered.
The elegant mare smiled down, placing a hoof on the new arrival's shoulder. "That is a beautiful name, I will try to answer as many of your questions and worries as I can, you can come to me whenever you need advice or comfort. My name is Rarity, I used to be an actress in Canterlot until one night, when there was an accident with the rigging holding the lights. Like you I found my way here as all ponies eventually do." Rarity softly stroked her new friend's mane, hoping to comfort her. "This land is known as Heaven."
Rainbow backed away from Rarity's soothing touch. "Wait, what are you talking about? I mean, Heaven is for..." She shook her head quickly looking around for signs of home. "No, I was just drinking with my friend, Pinkie's waiting for me back at home, I-" Her words cut short as a white hoof pressed against her lips.
"Rainbow Dash dear, I know how you are feeling. When the lights fell on me I woke up here, at first I refused to accept it. I was loved in Equestria, hundreds would come to Canterlot to adore my performance, my beauty and my acting. Inevitably, I needed to accept what had happened, that I had died." Rarity rubbed her hoof gently across the clearly worried pegasus' face. "We all miss our loved ones but there is no changing our fate. Nopony lives forever, even the princesses must inevitably follow."
"I can't be, dead." Rainbow Dash lowered her head in sadness, she couldn't be dead, she needed to take care of her sister. Pinkie couldn't support herself alone, she didn't know how to steal food or bits needed for medications, she was to kind to even think about such things. Her thoughts escaped her as a light blue aura approached her face, carrying with it a golden watch. "What's this?"
"It is your life Rainbow Dash, take a look inside." Rarity lowered the levitating watch into the pegasus' hooves. There was an engraving of a thunderbolt shooting from a cloud on its surface, the same image as her cutie mark. Rainbow cautiously opened the watch to reveal a second identical engraving on the inside. The clock itself was silent, no longer ticking, its hands and dials stuck forever on the time she last remembered. The time when a loud sound came rushing towards her. Tears slowly dropped on the surface of the clock as the realisation finally sunk in her mind. Rarity softly hugged her new friend, helping to support her in her time of need. "It's okay, I am here for you."
A short while passed before Rarity withdrew from her hug, levitating a golden chain around the blue mare's neck. "What's this for?" Rainbow finished drying her uncharacteristic tears.
"Attach your watch to it, as a reminder of your good life." Rarity brought her hoof to show a diamond engraved watch around her own beautiful neck.
Rainbow fitted the watch to the chain, making sure to secure it as she listened to her new friend's words. "I haven't exactly had a 'good' life." She sighed before trotting around in a circle, staring up to the boundless sky. "I can't even remember my parents, having to scavenge all my life for me and my sister. Stealing, cheating, lying, even gambling it all away for nothing." She gazed over to the white mare. "I don't really deserve to be here."
"All ponies go to Heaven." Rarity responded with a caring smile. "You may have had a bad life, but now you can rest in peace and happiness forever, is this not what you have always wanted?"
The pegasus slowly made her way to the edge of the cloud, looking down at the old home that tormented her. "It's not just what I want, Pinkie wants it to. But she is down there, helpless, I don't want her to die to be happy." She turned around grabbing the legs of the white mare. "Please, let me go back. I can't let her suffer I need to keep her safe!"
Rarity shook her head sternly. "You cannot go back, she will find a way to survive and if not. She will find happiness like us."
"She's not going to die!"
"Rainbow Dash." Rarity's voice became bold as she called out over her friends worries. "I know it is painful, believe me, I know. But you need to understand you cannot go back to the world of the living. Even if you could the gates of Heaven would not open for you again, your life has come to a stop."
Rarity gently removed her hoof from her new friend before turning around and trotting across the soft cloud sky. "Come with me Rainbow Dash, I know some other ponies who would love to meet you."
Rainbow didn't move an inch towards her friend, her mind worrying itself with her sister, she couldn't just forget about her and let her die. She couldn't just enjoy heaven and wait for to join in, she can't be so cruel to the only family she knows, one of only two ponies that ever cared for her. 'My life has come to a stop?' Cautiously she reached down to open her golden watch, the representation of her life eternally stuck at the time of her death. "Pinkie." Rainbow knew what she had to do, what she had to try. Carefully she took the winding screw in her lips, and began to turn.
"What are you doing? Rainbow Dash don't do that stop!" Rarity yelled loudly with sheer worry in her voice to try and stop her desperate friend, but her words fell on deaf ears. By either sheer will or luck the watch somehow managed to tick again, the cogs rotated painfully against each other, and the hands moved.
The final words Rainbow heard as she fell towards Equestria rung in her ears. "You can never come back."
Rainbow Dash awoke to immense pain, coughing up water as her broken body lay sprawled out on a jagged rock being struck by the tide. She could feel her body in agony, large wheel tracks crossed over her body where the heavy cart had run her over, breaking her back left leg as a result, the rest of her limbs were covered in cuts and bruises from the jagged rocks and even teeth marks from some unknown animals who must have been feasting on her tattered dead body. However, aided by the immense pain she felt one thing was for sure. She was alive again.
The barely alive pegasus struggled to lift herself up, checking down on her heavily wounded body. Around her neck lay her golden watch, though there was a difference, the gold looked corroded. Thinking back to the final words she heard, she feared she knew what the corrosion meant. "Pinkie." Rainbow struggled to move her lips, luckily rigor mortis had yet to take effect but it was still difficult to move her broken body after previously leaving it, added to the intoxication which returned more dilute than before.
Putting her worries behind her, the wounded pegasus climbed over the jagged rocks to the shore, cutting herself slightly more in the process. But she didn't care, Rainbow knew what she came back for, she had to help her sister. Even if it had to cost her an eternity of happiness.

domain: artistic


California voters weighed in on tax hike Measure M, and decided that, yes, they will approve of Metropolitan Transit Authority raising over a billion dollars for new projects. Proponents in this city said the much needed hike would create more than 400,000 jobs and new opportunities for Angelenos who need it most. Mayor Eric Garcetti, stomped hard for the measure, visiting black churches like West Angeles, and encouraging his constituents to get out and vote.
Supervisor Mark Ridley-Thomas was also a big supporter of the measure.
“This is also about jobs, jobs and more jobs,” he said.
“There is no other public construction project in this state that will generate 400,000+ jobs.”
M is an extension of Measure R, which voters approved in 2008. It is the fourth tax increase to help fund transportation projects here in Los Angeles.
The increase will become effective January 1, 2017 and remain in place until voters decide to end it. The measure also calls for regular independent audits to ensure accountability and transparency.
Garcetti said that Measure M was about people and their stories like the dilemma faced by an 82-year-old veteran without a public transportation option to get medicine or a South Los Angeles child who never visited the beach.
“Now with the Expo Line open to Santa Monica, all that public transportation fulfills the dream that lives within you. It’s the church network that makes sure that we touch the lives of individuals,” said Garcetti.
“I know many congregations have been impacted by Metro’s construction and expansion efforts,” said Bishop Charles E. Blake of West Angeles at an October breakfast meeting.
“But the good news is that we will all reap the benefits of an expanded and more reliable system that relieves traffic.
“At West Angeles COGIC, we have first-hand knowledge of the benefits of affordable and reliable transportation. Many of our congregants come to church by train and the Metro line and our employees use it to come to work.”


text:
Google’s Android mobile operating system ranked as the top smartphone platform with 51.7 percent market share, while Apple led as the top OEM with share of 38.9 percent, according to the latest ComScore MobiLens service, which reported key trends in the U.S. smartphone industry for the three-month average period ending February 2013.
Newly revamped BlackBerry ranked third with 5.4 percent share, followed by Microsoft (3.2 percent) and Symbian (0.5 percent). The company’s latest report revealed that 133.7 million people in the U.S. owned smartphones, good for 57 percent mobile market penetration, during the three months ending in February. This represents an 8 percent rise since November.
The iPhone helped propel Apple to the top spot among OEMs for the three months ending in February, representing a 3.9 percentage-point rise from November. Samsung, the OEM behind the popular Galaxy series of smartphones, ranked second, with 21.3 percent market share (up 1 percentage point). HTC followed, with a 9.3 percent share; Motorola, with 8.4 percent; and LG, with 6.8 percent.
HTC is looking to Facebook to help boost its struggling fortunes in the market. On April 4, the company was part of a major press event featuring Facebook CEO Mark Zuckerberg unveiling the HTC First, a smartphone built around Home, the social networking site’s software layer that connects users with their Facebook contacts.
In a signal that Apple is facing a mounting threat to its standing in the market, the First runs rival Android’s operating system and boasts a 4.3-inch display. Apple has come under increasing pressure to provide a larger screen for the iPhone. The iPhone 5 was the first Apple handset to feature a 4-inch screen, while Samsung, among many others, has been moving faster in the direction of large displays.
The latest Galaxy S smartphone from Samsung, for example, sports a 5-inch high-resolution screen. Other OEMs, including HTC, Sony and Nokia, are offering 5-inch displays as a way to lure customers. In essence, Apple is fighting on two fronts—against OEMs and their handset designs, as well as the increasing ubiquity of the Android platform, which can be found on a wide variety of smartphones at multiple price points.
For the three-month period ending in February, Android accounted for more than half (51.2 percent) of smartphone sales, up 5.8 percent from the same period last year, according to data released by Kantar Worldpanel ComTech earlier this week. Sales of Apple’s iPhone helped keep the iOS platform in second place with 43.5 percent of smartphone sales. However, that figure was down 3.5 percent from last year.
A March report from IT research firm IDC projected the worldwide smart-connected device space will continue to surge with shipments surpassing 2.2 billion units and revenues reaching $814.3 billion in 2017. Worldwide shipments of smart-connected devices grew nearly 30 percent year-over-year in 2012, crossing 1 billion units shipped with a value of $576.9 billion.

domain: news


text:
And kicking off with some exciting announcements.
On September 17th, I will be performing as the Poet Invited in Advance at Chicken Session #21. The last Chicken Session took place back in May as the final event of Verses Festival of Words. It was the first one I had attended, and it was pure magic. Here's a borrowed description from the Verses 2016 program:
“Inspired by Mike McGee’s Kitchen Sessions, and the local Under the Bed series run by RC Weslowski and Wilhelmina Salmi, Chicken Sessions is a house concert, a poetry and story performance space, a potluck, a party, a salon with some Louisiana hospitality tossed together and served up by host and instigator Pamela Bentley in a big, beautiful East Van heritage house.”
I was thrilled and honoured to be invited to perform, and I’m really looking forward to it. Mutya Macatumpag will be performing as the Musician Invited in Advance, and there will be 12 open mic performers throughout the day. I’ll post more details on my Events page once the Facebook event goes up.
I have a few upcoming publications as well! I have a story forthcoming in SAD Mag, and another (about honey bees and ghosts) coming out in September in Room’s Canadian Gothic issue, in the brilliant company of Aislinn Hunter, Amber Dawn, and so many others whose work I can’t wait to read. Here’s a sneak peak of the front and back cover:
You can pre-order this issue here. Only $12!
So, to wrap up, I’m enjoying summer, stoked to have my website up and running, and looking forward to the exciting things September has to bring!

domain: literature


HII announced today that its Newport News Shipbuilding division has redelivered the nuclear-powered aircraft carrier USS George Washington (CVN 73) to the U.S. Navy.
HII christened the Virginia-class submarine Massachusetts (SSN 798) at the company’s Newport News Shipbuilding division.
HII announced today that its Newport News Shipbuilding division has been awarded a $567.6 million subcontract modification from General Dynamics Electric Boat to provide long-lead-time material and advance construction activities for Columbia-class ballistic missile submarines.
HII announced that its Ingalls Shipbuilding division has received a $1.3 billion modification to a previously awarded contract from the U.S. Navy for the procurement of the detail design and construction of amphibious transport dock LPD 32.
HII’s Ingalls Shipbuilding division was awarded a $10.5 million contract today for the modernization period planning of Zumwalt-class guided missile destroyers, USS Zumwalt (DDG 1000) and USS Michael Monsoor (DDG 1001).
HII’s Ingalls Shipbuilding division delivered the Arleigh Burke-class guided missile destroyer Lenah Sutcliffe Higbee (DDG 123) to the U.S. Navy.
HII’s Newport News Shipbuilding (NNS) division hosted a keel authentication ceremony for Virginia-class submarine Arkansas (SSN 800).
HII’s Mission Technologies division has revealed a new medium-class unmanned underwater vehicle (UUV): REMUS 620.
HII’s Ingalls Shipbuilding has been awarded a $2.4 billion U.S. Navy fixed-price-incentive contract for the detail design and construction of amphibious assault ship LHA 9.
Global defense and technologies partner HII announced the delivery of three REMUS 100 unmanned underwater vehicles (UUVs) to the United Kingdom’s Royal Navy.


3. Important to start well for Eibar and Celta
Hoeness said no Bayern player would be rewarded beyond the best earners Manuel Neuer and Robert Lewandowski.
"I did not expect to run so fast. My expectation was to break 10.60s," Shi said. "After clocking 10.52s in the preliminaries, I just went all out in the final."
The announcement came a day after a 2-0 home loss to Palmeiras, a result that left Corinthians 13th in the 20-team standings with just two wins from eight matches.
Zhang introduced that his company set up the first community smart gym in Guiyang on July 10 this year and it has planned to establish 1,000 community smart gyms in three years in Guizhou.
However, Villas-Boas didn't think Alvaro - who earlier accused Angel Di Maria of spitting at him - would have committed such a wrongdoing.
He has also been capped 36 times for the Italian national team.
WASHINGTON, Sept. 11 (Xinhua) -- Teaming up for the very first time was no problem for German player Laura Siegemund and Russian veteran Vera Zvonareva, as the unseeded pair completed their dream run to the US Open women's doubles title with a straight-set victory over third seeds Nicole Melichar and Xu Yifan in the final on Friday.
Guoan broke the deadlock in the 30th minute as the ball fell for Zhang Yuning after a series of ricochets, who turned around and finished with a low-strike.
Iran will play Uzbekistan on October 8 in a friendly match in Tashkent and four days later they will face Tajikistan in Tehran.
"Asia and Taylor played a great match," Melichar continued. "We've known each other for so many years, played against each other so many times."


Much debate has recently been going on regarding the recently promulgated RPO (Amended) 1972 Ordinance. Some provisions in the RPO may face legal challenges and some are difficult to be implemented by the political parties due to time constraint. For instance, the new electoral rules had given an opportunity for the loan defaulting contestants to participate in the upcoming polls through rescheduling of their loans six months prior to the submission of application for candidacy.
But due to delay in promulgating the RPO, loan defaulters' bid to run in the polls is over as the stipulated timeframe of rescheduling their loans has ended. Legal experts have opined that such candidates may challenge the provisions in the courts for not providing the stipulated opportunity to them for remedying their disqualifications and there is a good chance that they may win the legal battle as it is indeed the fault of the government that it could not provide them with sufficient time.
The case of party registration can also bring in more legal battles. For instance, in order to meet the criteria for registration with the EC, the parties are required to revise their constitutions and elect new committees through national councils. Under the state of emergency, this seems a difficult proposition. The parties will also have to sever ties with their front organisations and chapters abroad. The idea of bringing the parties under registration is welcome but if the parties file a writ petition with the High Court, challenging the legality of the provision to do away with front organisations, then things will get murkier. And then the government is also not barring those convicts from polls whose appeals are pending with the higher courts and thus the CA's recent call for electing “clean and competent” candidates rings hollow. Now it appears that the government and the EC may ultimately have to bow down to the pressure of the political parties to move forward with the electoral process and this will only weaken the image of the government. So despite the fact that some of the provisions of the RPO are praiseworthy (registration of the parties, disallowing civil and military bureaucrats and heads of NGOs from participating in polls till 3 years have elapsed, option of “no” vote etc), the delay in promulgating the electoral laws may hinder proper implementation of the laws.


According to Twitter user, @hongxing2020, NVIDIA will be launching three new graphics cards, the GeForce RTX 3090 SUPER, RTX 3070 Ti, and RTX 2060 in early 2022.
NVIDIA GeForce RTX 3090 SUPER, RTX 3070 Ti SUPER 16 GB & RTX 2060 12 GB Rumored To Launch Early Next Year
The tweet states that NVIDIA isn’t only prepping up new Ampere SUPER cards but also going to refresh its Turing lineup.
nvidia 2022年1月 公開：
— hongxing2020 (@hongxing2020) October 4, 2021
If the above information is correct, then not only will we be seeing the new GeForce RTX 3090 SUPER (GA102) graphics card, but also the RTX 3070 Ti with 16 GB of memory. Also seen will be the NVIDIA GeForce RTX 2060 with 12 GB of memory capacity.
Recently, it was reported that NVIDIA was readying its 12 GB GeForce RTX 2060 variant for launch in Q1 2022 to tackle GPU shortages as those are now expected to persist throughout 2022.
It is also unknown what will happen to the current three models. Could NVIDIA be upgrading the RTX 3070 Ti to utilize more memory at a higher efficiency than the current RTX 3080 series? It would not be surprising since the GeForce RTX 3060 offers more capacity than its Ti variant. But that would suggest that both RTX 3080 and RTX 3080 Ti would end up with lower VRAM than the upgraded RTX 3070 Ti graphics card.
The NVIDIA GeForce RTX 30 SUPER series of desktop GPUs were also recently tweeted by @kopite7kimi:
Let’s make a summary.
3090S 10752 24GB G6X
3080S 8960 12GB G6X
3070S 5888 8G G6X
3060S 5632 12G G6
Although I doubt the specs of some of them and the name of 90S.
— kopite7kimi (@kopite7kimi) September 22, 2021
The above tweet from September showed that we should be expecting to see NVIDIA release an RTX 3090 SUPER with 24GBs of memory, the RTX SUPER 3080 with 12GB memory, the RTX SUPER 3070 with 8GB of memory, and the RTX SUPER 3060 with 12GB of memory. It is possible that NVIDIA is removing their 8GB variants currently on the market to make way for stronger capacity GPUs. If so, then it would place them above AMD with their launch of the Radeon RX 6600 standard and XT variant with eight gigabytes onboard.
Currently, both NVIDIA and AMD are showing that they are moving away from producing any further GPUs with less than eight gigabytes of memory onboard, allowing for consumers to utilize stronger and more efficient GPUs than previous years. Also, with the current market prices for GPUs still far above normal pricing, it is possible that Intel, AMD, and NVIDIA are all three preparing newer cards with more pleasing additions for when the market finally decides to lower and plateau at more reasonable prices.


text:
December 23, 2012December 23, 2012| | 0 Comment
Hello Aaron in Antarctica. Camp position South 85 degrees 27 decimal 483 minutes, position West 081 degrees 50 decimal 032 minutes. Time traveled 9 hours, distance traveled 10.5 miles. I got a good strong 15 to 20 knot head wind, it's really starting to blow snow around which is actually a great birthday gift for me cause that means it's packing everything down. Bad thing of course is the head wind but we'll take it. Amazing how much more that head wind seems to cut in here than it did 2 weeks ago or even 3 weeks ago, man it's quite surprising. Went down a huge hill, I've been going up a huge hill and I'm still on that huge hill. Still can see that Transantarctic mountain range which is totally cool can not complain about that. Things have been going pretty well, doing some gear repair right now, one of my, my right ski, the front edge is quite chewed up to the wood core which is never good, that means water can get in there, fracture and broken ski and instant trip over. Like everything else, oh this happens trip over, this happens trip over, I don't want to do that. I got it all covered in JB weld, actually the ski fits in the tent just perfectly thank goodness I can keep it warm and safe and it doesn't get wet while the epoxy sets up, of course I just rolled over and put my shell pants gooed in it so I'm sure that'll be very nice. Let's see question came in, how did I learn about tea bag baths? There's actually a book out in 2012 called Polar Exploration by a european, this guy has 10 plus years experience, I got quite a few tid bits from there other than him saying to bring a better shovel than the junk I bought. Yea the tea bag bath is actually is really handy. Another question from my mom is how long is summer here and how warm does it get? Summer started yesterday and it'll end on March 22nd or whatever it is. So summer here lasts just like up in the Northern hemisphere, it's just called the Austria summer just like Australia because it's the... So while you guys up in Wyoming in the Northern states are freezing your butts off, we're down here, well if I was in Australia I'd be sittting on the beach toasty warm but down here yea no definitely not. Right now it's probably minus 15, minus 20 outside it can get pretty icy here. On the coast 2 months ago I noticed McMurdo Station was reporting 5 degrees but 1 month ago Vostok Station was reporting minu 40 as the high. So right now I understand Union Glacier is reporting about minus 10 and I expect that once I get to the South Pole I was warned it could still be minus 35 so. Yea the warmest it ever gets is about 5 degrees above zero fahrenheit but in general it stays minus 10 to minus 20 most of the time unless a storm comes in or something so it's definitely not warm that is for sure. One interesting tid bit is the sun rises and the sun sets exactly once a year, so the sun will actually set on March I think it's 22nd on the solstice, so that's the last time you'll see the sun here until September 22nd when it rises so. Exactly one sunset and exactly one sunrise, granted it takes a while but. The sun is about 25 to almost 30 degrees up in the sky where as up in higher latitude would actually be dead over head so it's as high as it gets and now it only gets colder. Out!

domain: geography


text:
Sociology: Themes And Perspectives is a comprehensive reference book on the subject of sociology.
Summary Of The Book
Sociology: Themes And Perspectives presents an extensive introduction to the field of sociology. It contains a detailed coverage of the concepts. For more than twenty years, it has served as a textbook for various undergraduate courses on the subject. It is a handy reference book for aspirants of the Indian Civil Services examination who have chosen sociology as one of their subjects.
The book covers concepts such as social stratification, sex and gender, poverty, social exclusion, religion, crime and deviance, education, politics, power, communication, and the media. It also explores topics like race, ethnicity, nationality, health, medicine, work, unemployment, culture, and identity.
This book was first published in 1980. This edition is a 2011 reprint by Oxford University Press.
About The Authors
M. Haralambos has written books like Sociology: A New Approach, Sociology Themes And Perspectives, and Soul Music.
R. M. Heald has co-authored the book Sociology: Themes And Perspectives.
Certified Buyer, Bangalore Urban
a good book to start
Certified Buyer, New Delhi
Not for current syllabus - PLEASE DON'T BUY
Siddharth Kataria Kataria
very good book for upsc aspirants
Not much substance
Certified Buyer, Chitradurga
complete book for sociology
Certified Buyer, Hyderabad
6 months ago

domain: library


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text:
Owning residential properties may be a really effective way of supplementing your wages, or even your primary source of revenue. However, many home owners reside hundreds of miles away from their residential homes, and a property maintenance firm is the only realistic option to ensuring that rentals are received, the property is adequately managed, prospective renters are checked and the other aspects of maintaining the property of a customer are handled.I strongly suggest you visit Bluesky Living to learn more about this.
In any other sector, though, there are land maintenance firms take their obligations very seriously and some taking advantage of their clients and going through the motions of handling their assets. And how do you say you’re doing it with the former to stop the latter?
Below are few tips for what to search for in a property maintenance company: note that this is a corporate relationship-when you meet various firms that will be the most relevant of your head. You are searching for an agency that has expertise, that provides its facilities at competitive prices and that handles its affairs professionally. That’s your real estate and basically your liability. Make sure you chose a property management company which instills confidence.
Ask regarding their rates-Don’t let your sole greatest concern be the size. It is fair to expect the best companies to demand more for their facilities. Probably, they offer more accountability and do a more thorough job. Just make sure you have the maintenance costs in every deal.
Provide a summary of the other assets they control-A reputable property services company would be able to include a summary of the assets they maintain. Visit any of the property of their clients, step out of the vehicle and have a walk around and make sure they handle certain assets like they say they do.
Inquire on how vacancies they sell-vacancies are part of buying investment properties. Business and residential renters come and go, so it will create a big impact in the bottom line by the time it takes to find and screen a new one! Look for a real estate marketing firm with a good web presence to sell and promote the properties to eliminate vacancies.
Daily income and expenditure reports – Your rental assets are your corporation again, so be sure you and your organization view your revenue property like a normal profit and expenditure reporting enterprise. Quarterly reports provide an important management resource to monitor costs, detect industry patterns and find prospects for cost savings and revenue enhancement.
All of these factors and more are really useful approaches for qualified property maintenance firms to distinguish the wheat from the chaff. Whether you live hundreds of miles away or in the same location and prefer not to manage your property yourself, retain a property management company with experience in managing residential and commercial property in the Louisville area and offer customized management plans to meet the unique needs of your situation.


text: Introducing the Love Teacher Tee Shirt! This stylish and comfortable tee is perfect for any teacher who wants to show their love for their job. The bold black shirt is accented with a colorful teacher design in love word art, making it a truly eye-catching shirt. Whether you're wearing it to school or out on the town, this shirt is sure to get you noticed. So show your love for teaching with the Love Teacher Tee Shirt!


Back in February 2004, The Vancouver Sun's Vaughn Palmer reported on the curious case of Bill Gipps. Five months earlier, Mr. Gipps's one-man company GR8 IDEAS Management Consulting Services Ltd. had been directly awarded an 18-month contract with the provincial government's alternative service delivery secreteriat, paying him $1,200 a day to a maximum of $550,000. At the time, Mr. Palmer noted Auditor General Wayne Strelioff's view that such awards are "contrary to government's principle of fair and open competition." And it seems the secretariat has since polished up its contracting policies. Last week, the office posted a request for proposal on BC Bid seeking qualified contractors to work as alternative service delivery solution consultants - the same post occupied by Mr. Gipps. The government has declined to inform prospective contractors what projects they will be working on due to confidentiality concerns. Nor have they said whether successful applicants will be compensated as handsomely as Mr. Gipps (although, in fairness, no one has yet asked).


text:
Ball, Onion & Drop Ornaments
- Brand: Robert Stanley
Put together a charming, coordinated Christmas tree in a jiffy with this lovely ornament pack! Ball, Onion & Drop Ornaments are made of glass and come in various colors and various shapes including round, onion-shaped, and finial-shaped with either shiny or matte finishes. Each is completed with a metallic-colored metal topper and some have glittered designs. Hang them from the boughs of your tree for a delightful boost of color and cheer this holiday.
- Length: 2 7/8" - 5 1/8"
- Width: 1 9/16" - 2 9/16"
Package contains 24 ornaments.
Item not available in Hobby Lobby Stores.
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text:
Teenage Rangers Fan Dances After Catching Hamilton Homer
17 year old Trent Williams is a dedicated Rangers fan. At Monday night’s game, he dashed out on the grass to snag a home run ball hit by Josh Hamilton and then busted a move doing “The Sprinkler.” He’s got the attention of the world now. Sports Center has a video history of Trent’s other awesome catches. Have a look!
- UNICEF Using Music to Educate Liberia About Ebola with ‘Ebola is Real': Listen
- Women In Halloween Costumes
- Singing Nun Releases Debut Single and It’s Madonna’s ‘Like a Virgin’
- Lorde’s ‘Hunger Games’ Soundtrack to Feature Kanye West, Charli XCX, Tinashé
- Taylor Swift is Your Tour Guide in ‘Welcome to New York’
- Watch Taylor Swift’s Visit with the Naked Chef, ‘Shake It Off’ Parody ‘Bake It Off’
- You Are Not Alone: James Blunt Also Got Sick of Hearing ‘You’re Beautiful’
- Watch Kelly Clarkson Cover Sam Smith’s ‘Stay With Me’
- What’s Hot: Catwalk in Cowtown Fashion
- Get Your Pre-Sale Tickets To Not So Silent Night!

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NASA’s 2011 Future Forum – College Park, MD
8 de agosto de 2011
Thursday, August 11, 2011
8:00 a.m. – 4:00 p.m.
University of Maryland
Samuel Riggs IV Alumni Center
College Park, MD
Through NASA, America Continues to Dream Big: NASA’s future aeronautics, science and exploration missions are grand in scope and bold in stature. These future missions require investments in innovative technology, science and education today. More information.
NASA’s impact on the America’s technologies, workforce and economy are based on investments and innovations from the past. Today’s investments in education, science, innovation and space technology will maintain NASA’s position on the cutting-edge while stimulating our economy and the global competitiveness.
NASA’s missions are a catalyst for the creation of new products and services; new businesses and industries; and high-quality, sustainable jobs while also serving as an inspiration for young people to pursue science, technology, engineering, and mathematics (STEM) education and career paths.
– Dr. Waleed Abdalati, NASA Chief Scientist,
– Dr. Laurie Leshin, Deputy Associate Administrator for NASA’s Exploration Systems Mission Directorate and
– Leland Melvin, Astronaut and NASA Associate Administrator for Education
Registration for this event has closed but please join us LIVE on the day of the event on NASA TV or via the web www.nasa.gov/ntv
NASA’s Future Forum series will be visiting university campuses around the country throughout this year. We anticipate convening 3-4 additional Forums- geographically spread across the US where you can attend one near you.


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Kidneys And Acidbase Balance
The kidneys have two very important roles in maintaining the acidbase balance:
The kidneys are slower to compensate than the lungs, but renal physiology has several powerful mechanisms to control pH by the excretion of excess acid or base. The major, homeostatic control point for maintaining a stable pH balance is renal excretion.
Bicarbonate does not have a transporter, so its reabsorption involves a series of reactions in the tubule lumen and tubular epithelium. In response to acidosis, the tubular cells reabsorb more bicarbonate from the tubular fluid, and the collecting duct cells secrete more hydrogen and generate more bicarbonate, and ammoniagenesis leads to an increase in the formation of the NH3 buffer.
In response to alkalosis, the kidneys may excrete more bicarbonate by decreasing hydrogen ion secretion from the tubular epithelial cells, and lowering the rates of glutamine metabolism and ammonium excretion.
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Intravenous Solutions: Lactated Ringer’s Solution
Another way in which acid-base loads can enter the body is via intravenous solutions. Hospitalized patients receive a variety of intravenous solutions a common one being lactated Ringer’s solution, a mixture of salts that contains lactate at a concentration of 28 mEq/L. The pH is approximately 6.5. However, this is an alkalinizing solution for the same reason described as the fruit juice paradox earlier. Lactate is an organic anion, the conjugate base of lactic acid, and when oxidized to CO2 and water, it takes a hydrogen ion from the body fluids, thereby producing bicarbonate. Lactated Ringer’s should not be confused with a lactic acidosis associated with certain forms of shock. In those situations, the body produces equal numbers of hydrogen ions and lactate and the result is to acidify the body fluids.
A simplified overview of the renal processing of acids and bases is as follows: The acid-base component of highest concentration in the blood is bicarbonate , and even under unusual circumstances, the kidneys have to reabsorb most of the filtered load. This is accomplished primarily in the proximal tubule, thus conserving plasma bicarbonate. The proximal tubule also secretes limited amounts of organic bases or weak organic acids and acid equivalents as previously described in Chapter 5. Then, in the distal nephron , the kidneys secrete either protons or bicarbonate to balance the net input into the body .
Treatment Of Respiratory Acidosis
A doctor should be seen immediately to treat acute respiratory acidosis, as this can be a life threatening condition. Treatment is targeted to the cause.
Bronchodilator medications may be given to correct some forms of airway obstruction. If your blood oxygen level is too low, you may require oxygen. Noninvasive positive pressure ventilation or a breathing machine may be necessary.
To treat chronic respiratory acidosis, the underlying cause needs to be determined in order for proper treatment to take place. The cause could be from an organ deformity, an infection, or some type of inflammation. Each cause may require a different treatment ranging from antibiotics to a breathing machine.
In either case, if you smoke, you will be advised to stop.
Also Check: Constipation Kidney Stones
Anaerobic Metabolism Of Carbohydrate And Fat
The normal oxidative metabolism of carbohydrate and fat is acid-base neutral. Both carbohydrate and triglycerides are oxidized to CO2 and water. Although there are intermediates in the metabolism that are acids or bases, the sum of all the reactions is neutral. However, some conditions lead to production of fixed acids. The anaerobic metabolism of carbohydrate produces a fixed acid . In conditions of poor tissue perfusion or strenuous exercise, this can be a major acidifying factor. The metabolism of triglyceride to -hydroxybutyrate and acetoacetate also adds fixed acid . These processes normally do not add much of an acid load but can add a huge acid load in unusual metabolic conditions .
Metabolic Acidosis And Metabolism
Summary of main renal metabolic pathways altered between kidney transplant recipients with or without acidosis. Bulk RNA sequencing data using RNA from kidney biopsies of KTRs identified genes altered between patients with or without acidosis, but with comparable eGFR. These genes participate in metabolic activities shown in this figure in black. Red lines show molecular pathways that had genes restored by alkali therapy. Blue arrows show direct biochemical reactions, and blue dashed lines show indirect biochemical reactions. Black arrows show movement of molecules. Data originally published in . TCA cycle tricarboxylic acid cycle , P5P pyridoxal-5-phosphate, GSH glutathione, THF tetrahydrofolate
Two central questions derive from these observations: Does deranged metabolism define trajectories towards faster or slower kidney function decline in chronic kidney disease or does it simply reflect disturbance from other causes? Cippà et al. identified early markers associated with these trajectories in biopsies of patients submitted to renal ischemia and reperfusion because of transplantation . They identified that genes associated with mitochondrial function, senescence, and inflammation were among the most prevalent genes associated with different trajectories. Given the roles of pH in metabolism and mitochondrial function described previously here, is pH a key factor influencing these trajectories, or is it only a sensitive biomarker of kidney damage?
Also Check: Flomax For Kidney Stones In Woman
Metabolism Of Dietary Weak Acids
Fruits and vegetables, particularly citrus fruit, contain many weak acids and the salts of those acids . We all know that citrus juice is acidic, with some fruit juices having a pH below 4.0. Interestingly, metabolism of these acidic substances alkalinizes the blood, sometimes called the fruit juice paradox. The complete oxidation of the protonated form of an organic acid to CO2 and water is acid-base neutral, no different in principle than the oxidation of glucose. However, the complete oxidation of the base form adds bicarbonate to the body, that is, organic anions are precursors of bicarbonate. One can think of metabolizing an organic base anion as taking a hydrogen ion from the body fluids to protonate the anion, thus converting it to a neutral acid, and then oxidizing the acid. The loss of the hydrogen ion, as emphasized above, adds bicarbonate. This loss of hydrogen ions greatly exceeds the number of free hydrogen ions present in the original fruit juice. Although its pH is low, there is far more base than free hydrogen ions. Before oxidation, the mixture is acidic, but on complete oxidation to CO2 and water, the result is addition of base.
Ammonium Elimination By The Distal Nephron
When tubule fluid enters the early distal tubule, the ammonium concentration is about 1.2 mmol/L. Then, something happens, and the ammonium concentration of the distal nephron increases massively. Moreover, it increases even more massively if the organism is experiencing metabolic acidosis, which strongly suggests a regulatory role. Good et al measured a collecting duct ammonium concentration of 33.8 mmol/L, and as high as 73.6 mmol/L in rats with a chronic acidosis.
How does this happen? Nobody actually knows, and the uncertainty is reflected in the broken arrows in the diagram above. The concentration of ammonium in the interstitial fluid of the inner medulla is quite high but clearly that is not high enough to create a concentration gradient and drive the ammonium out by passive diffusion. The ammonium ion itself is positively charged, and to expect that it would cross the membranes on its own is not especially plausible, which suggests that there is some sort of transporter involved. Karim et al document the contribution of RhBG and RhCG proteins which seem to permit the entry of NH3 into the cells, potentially explaining how it moves through the basolateral membrane. For this to happen, NH4+ would need to split into NH3 and H+, get transported into intercalated cells, and then get excreted separately to recombine again in the urine, as depicted in this crude diagram:
Recommended Reading: Does Carbonation Cause Kidney Stones
Hydrogen Ion Excretion On Urinary Bases
We see that the identical transport process of hydrogen ion secretion achieves both reabsorption of bicarbonate , and acid excretion, with addition of new bicarbonate to the blood. At first glance, this seems like a contradiction: How can the same process produce 2 different results? The answer lies in the fate of the hydrogen ion once it is in the lumen. For secreted hydrogen ions that combine with bicarbonate , we are simply replacing filtered bicarbonate that would have left the body. The hydrogen ion is incorporated into water. In contrast, when secreted hydrogen ions combine with a nonbicarbonate base in the lumen of the distal nephron, where little if any bicarbonate remains, the hydrogen ion is excreted and the bicarbonate produced in the cell and transported across the basolateral membrane is new bicarbonate, not a replacement for filtered bicarbonate.
Module : Fluid Electrolyte And Acid
- Identify the most powerful buffer system in the body
- Explain the way in which the respiratory system affects blood pH
Proper physiological functioning depends on a very tight balance between the concentrations of acids and bases in the blood. Acid-balance balance is measured using the pH scale, as shown in. A variety of buffering systems permits blood and other bodily fluids to maintain a narrow pH range, even in the face of perturbations. A buffer is a chemical system that prevents a radical change in fluid pH by dampening the change in hydrogen ion concentrations in the case of excess acid or base. Most commonly, the substance that absorbs the ions is either a weak acid, which takes up hydroxyl ions, or a weak base, which takes up hydrogen ions.
|Table 1. The pH Scale
|Battery acid, strong hydrofluoric acid
|Hydrochloric acid secreted by stomach lining
|Lemon juice, gastric acid, vinegar
|Grapefruit juice, orange juice, soda
|Soft drinking water, black coffee
|Great Salt Lake, milk of magnesia
|Liquid drain cleaner
Also Check: Is Watermelon Good For Kidney
Changes In Ph And Ion Concentration Along The Nephron
Again, its time for one of those huge diagrams of renal tubular pH, with unreadably small writing . The only reason this exists is because in Question 12 from the second paper of 2014, the college asked us to “describe… the changes in urine pH along the nephron”, for 80% of the marks. So, that’s what it would look like if you tried to answer with a diagram:
If this horror has any merit, it is in demonstrating what happens with an increased bicarbonate load, i.e. a metabolic alkalosis. The proximal tubule is the main site of reabsorption, and elsewhere in the tubule the mechanisms of bicarbonate reclamation are relatively weak and lack the capacity to make up for the added bicarbonate delivery to the distal nephron. This means the tubular pH would rapidly approach some sort of maximum value and it would remain there for the length of the tubule.
Koeppen, Bruce M. “The kidney and acid-base regulation.” Advances in physiology education .
McNamara, J., and L. Worthley. “Acid-base balance: part I. Physiology.” Critical Care and Resuscitation 3 : 181-187.
Atherton, John C. “Role of the kidney in acidbase balance.” Anaesthesia & Intensive Care Medicine 16.6 : 275-277.
Weiner, I. David, Jill W. Verlander, and Charles S. Wingo. Core Concepts in the Disorders of Fluid, Electrolytes and Acid-Base Balance. Springer, Boston, MA, 2013. 203-233.
Skelton, Lara A., Walter F. Boron, and Yuehan Zhou. “Acid-base transport by the renal proximal tubule.” Journal of nephrology 23.0 16 : S4.
The Role Of The Kidney In Acid
The kidneys have two main ways to maintain acid-base balance – their cells reabsorb bicarbonate HCO3 from the urine back to the blood and they secrete hydrogen H+ ions into the urine.
Our kidneys filter blood continuously by distributing the blood that comes into the kidney to millions of tiny functional units called .
Each is made up of the glomerulus, or a tiny clump of , where blood filtration begins.
When blood passes through a glomerulus, about one-fifth of the plasma leaves the glomerular capillaries and goes into the renal tubule.
Reabsorption of the good stuff—water and electrolytes—and leaving behind the bad stuff—waste products and acid— is the job of the the .
The renal tubule is a structure with several segments: the , the U- shaped with a thin descending and a thick ascending limb, and the , which winds and twists back up again, before emptying into the collecting duct, which collects the final urine.
Each of these tubules is lined by brush border cells which have two surfaces.
One is the apical surface that faces the tubular lumen and is lined with microvilli, which are tiny little projections that increase the cells surface area to help with solute reabsorption.
The other is the basolateral surface, which faces the peritubular capillaries, which run alongside the nephron.
So with , as the filtrate leaves the glomerulus, it first goes through the proximal convoluted tubule.
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Other Factors Which Affect Renal Acid
There a few other peripheral matters to attend do, with regards to renal acid-base handling. As all must surely have noticed by now, the movements of sodium and potassium are key to renal acid-base balance management. And as sodium handling and potassium handling are tightly regulated by various neurohormonal actors, it stands to reason that these actors will have some indirect effect on acid-base handling as well.
Pulmonary Role In The Acid
Various Buffer systems and their role in the acid-base system:
HCO3 / H2CO3
|Protein / hydrogenated protein
|HPO4 / H2PO4
Recommended Reading: Can A Kidney Infection Cause Diarrhea
Functions Ofthe Buffer System:
How Do We Maintain Water Balance In The Body
Thirst is one of the most important mechanisms to maintain water balance. When the body needs water, nerve centers deep within the brain are stimulated, resulting in the sensation of thirst. The sensation becomes stronger as the bodys need for water increases, motivating a person to drink the needed fluids.
Read Also: Does Red Wine Cause Kidney Stones
What Is The Role Of Urinary Ammonium Excretion
There are different views on the true role of NH4+ excretion in urine. How can the renal excretion of ammonium which has a pK of 9.2 represent H+ excretion from the body?
One school says the production of ammonium from glutamine in the tubule cells results in production of alpha-ketoglutarate which is then metabolised in the tubule cell to new bicarbonate which is returned to the blood. The net effect is the return of one bicarbonate for each ammonium excreted in the urine. By this analysis, the excretion of ammonium is equivalent to the excretion of acid from the body as one plasma H+ would be neutralised by one renal bicarbonate ion for each ammonium excreted. Thus an increase in ammonium excretion as occurs in metabolic acidosis is an appropriate response to excrete more acid.
The other school says this is not correct. The argument is that metabolism of alpha-ketogluarate in theproximal tubule cells to produce this new HCO3- merely represents regeneration of the HCO3 that was neutralised by the H+ produced when alpha-ketoglutarate was metabolised to glutamate in the liver originally so there can be no direct effect on net H+ excretion. The key to understanding is said to lie in considering the role of the liver. Consider the following:
- How to get rid of 1,000mmol/day of alkali?
- How to get rid of 1,000mmol/day of the highly toxic ammonium?
2 NH4+ + 2 HCO3- => urea + CO2 + 3 H2O
The body has two ways in which it can remove NH4+:
Other points are:
Renal Control Of Acid Base Balance
Read Also: Can Stress Cause Kidney Infection

domain: chemistry


text:
The Elements Way™. Simply the Best Massage
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Why do we do it? Because at Elements Campbell, we only do massage. Our expert therapists deliver a massage that is tailored to your individual needs, every time.
We have weekly massage appointments available to accommodate any schedule. Contact us to request a session, or visit us today. Walk-ins welcome!
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domain: health


text:
World Cuisine Recipes
Find quality, kitchen-tested recipes for popular foods from around the world that are ideal for everyday dining and entertaining.
Three Milk Cake - Pastel Tres Leches
This creamy cake will melt in your mouth. Its blend of three types of milk make this traditional cake of Latin origin an excellent way to impress your guests.
Asian Spring Asparagus
The traditional Asian flavors in this side dish really make the asparagus come alive.
Linguine with Fresh Tomatoes and Asparagus
Easy, colorful and truly delicious, this pasta dish is an excellent choice for entertaining or when you'd like a fresh garden-inspired family meal.

domain: food


The lovebirds have known each other for years, but it was only a few years ago that they started dating.
A Romanian TV personality, Iulia met Salman back in 2013 when the actor went to Romania for a recce for Jai Ho, and the rest, as they say, is history.
Anushka Sharma and Virat Kohli Even Salman's Sultan co-star Anushka Sharma is happily dating cricketer boyfriend Virat Kohli. A celebrity himself, Virat's relationship with Anushka has been a daily dose of fodder for gossip mills.
Anand, who attended school in America, owns a fashion line called Bhane.
And rumours have it that the two have been going out for quite some time now.
Ileana D'Cruz and Andrew Kneebone Ileana D'Cruz is not just on a professional high with the success of her recently-released film Rustom, but is also in a happy space as far as her relationship with Australian boyfriend Andrew Kneebone is concerned.


text: Description: OUTSTANDING 26 ACRE HORSEFARM/ESTATE. Built in 2002, this Equestrian's Delight features an exquisite 3400 sq. ft., 10 room Colonial with 1st floor office, Laundry and magnificent sun room overlooking a huge patio and lake. Also includes 48 x 30 equipment barn, 50 x 40 two story garage with 14' overhead door for 45 'Motorhome, and kitchen with full bath and loft , ideal for caretaker or guest. Horses will love the 72 x 32 stable with 8 12 x 10 stalls, plus wash bay, and a fantastic 90 x 60 indoor riding arena. All this hidden away on a dead end road in South Range School District PLUS......FREE GAS!

domain: hobby


text: As detailed above, this was first performed in the chronic LCMV model, leading to enhanced control of viral infection (118, 119). On the other hand, IRF4 antagonizes IRF5 largely through binding to comparable sequences on target genes as well as by competing for MyD88 conversation (77, 78). IRF4 regulates both CD4 and CD8 T cell differentiation, as well as B cell maturation [examined in (79)]. In addition, unlike IRFs 1, 5 and 8, which are associated with polarization towards M1 macrophage phenotype, IRF4 is usually involved in skewing towards anti-inflammatory M2 phenotype (80). In an acute contamination, IRF4 was shown to help sustain virus-specific CD8 T cell effector functions and prevent establishment of a chronic contamination, but it induced immunopathology (81). However, in chronic LCMV contamination, IRF4 suppressed effector cytokine production, increased inhibitory receptor expression and reduced anabolic metabolism in virus-specific CD8 T cells, and further repressed development of memory T cells (82). It did, however, promote growth and maintenance of the antigen-specific T cells, as well as prevented immunopathology (82). Overall, IRFs play important functions in regulating IFN-I signaling and, consequently, antiviral CRT-0066101 activities. It is therefore not surprising that viruses specifically target the functioning of these factors in order to prevent IFN-I induction. Viruses such as HSV, hepatitis C (HCV), dengue and HIV have dedicated some of their viral proteins to inhibit IKK-, IKK- and TBK1-mediated phosphorylation of IRFs, thereby dampening IFN-I signaling [examined in (83)]. HIV-I further uses its viral protein R (Vpr) and viral infectivity factor (Vif) to target IRF3 for degradation (84). Human papillomavirus (HPV) and paramyxoviruses (Measles computer virus, Newcastle disease computer virus) can interact with IRF3 and inhibit its transactivation potential or prevent its translocation into the nucleus (85). Furthermore, viruses have been shown to prevent the association of IRFs to the promoters of their target genes, as illustrated by HSV and Kaposis sarcoma-associated herpesvirus (KSHV) that prevent IRF3 binding to IFN promoter regions (86, 87). KSHV uses its viral homologs vIRF1 and vIRF2 to prevent IRF3-dependent gene transcription and vIRF3 to prevent IRF7 from binding to its target genes [examined in (88)]. As well, viruses have developed to exploit IRFs for their own benefit. HIV-1 induces IRF1 expression, which it exploits to stimulate viral transcription of its genome in the early phases of contamination as well as to increase T cell activation to favor computer virus replication. Once it achieves its goals, HIV-1 then directs its Tat protein to inhibit the IRF1 transcriptional Rabbit Polyclonal to GIPR activities and/or facilitates its proteasomal degradation [examined in (89)]. Diverse functions of interferon stimulated genes in viral contamination The activities of IFN-Is are potentiated by hundreds of ISGs that are directly stimulated downstream of IFNAR. ISGs include antimicrobial proteins, chemokines, cytokines and other immune mediators that induce recruitment of immune cells CRT-0066101 and inflammation. ISGs play diverse roles in many cellular processes such as migration, antigen processing and presentation, cellular activation, differentiation, mitosis and apoptosis. To add to this complexity, cell-type specificity, ISG expression kinetics, duration and context of signaling all likely contribute to the impact of IFN-Is on immune cell function. Antiviral and anti-proliferative functions of ISGs First discovered for their essential role in antiviral immunity, many studies have characterized the antiviral and anti-proliferative properties of ISGs. CRT-0066101 A productive computer virus contamination requires computer virus access, uncoating and RNA/DNA replication in the nucleus or cytoplasm of the infected cell. The viral genome CRT-0066101 is usually then transcribed into new viral RNA that is either translated into viral proteins or gets incorporated into new virions. The mature computer virus particles are then released in order to initiate contamination of new target cells. IFN-Is stimulate expression of genes that will target each of these computer virus replication cycle actions, and in so doing prevent spread of contamination. First, an ISG family of IFN inducible transmembrane proteins (IFITMs) interferes with membrane fusion thereby blocking cellular access of a broad range of viruses including HIV, WNV, Ebola computer virus, Zika computer virus and influenza A computer virus, while the tripartite motif 5 alpha (TRIM5) E3 ubiquitin ligase induces premature disassembly of the incoming virion capsid thus blocking synthesis of the.

domain: biology


text:
Digital project that investigates the history of Georgia Avenue, which once served as an important commercial thoroughfare in the neighborhoods south of downtown Atlanta, and is now the southern edge of GSU’s campus. This interactive historical narrative rediscovers a neighborhood that was entirely replaced by urban renewal projects, and explains why Summerhill, and other “stadium neighborhoods” in Atlanta, were so thoroughly transformed over the course of the twentieth century.
- Visit Resource
- Streetscape Palimpsest: A History of Georgia Avenue
- Marni Davis, Ph.D., History Department, Georgia State University
- Arts & Culture


text: I finally got off my booty, and opened up my etsy store! You can see some pictures of what I've got for sale right now in the right column, or click the link, and see everything that Ive managed to get up for sale. I also joined the Etsy Beadweavers Street Team! What a talented group of beaders belong to this group. Every month they have a challenge, and then they have a vote for the winner on their blog http://etsy-beadweavers.blogspot.com/ . This months challenge theme was Art Deco, and here is a picture of all the entries. Voting takes place on the blog on the 9Th of August(right around the corner) so go on over, and place your votes!


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Reupholstering miniature furniture is sooooo hard. Who’s got time for that?
A few months ago, I was staring at two light green armchairs in my paneled library roombox. “Nooooooo”, I kept thinking, “that light green color totally works”. And “silk is the new leather.”
Eventually I bowed to the inevitable: only dark green leather armchairs would work. There’s a reason things become cliche.
Because they look GOOD! Because I took the lazy way out and I painted them with fabric paint.
- Use “Slick” fabric paint mixed with regular fabric paint. You want it to have a little sheen, a little slickness.
- Once the paint has thoroughly dried, rub clear furniture wax all over it and then buff with a soft cloth to get the leather look.
Yay, soooooo easy!

domain: design


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Rochester's mayor is calling for oversight to a bill that will release $435 million for the second phase of the Rochester City School District's school modernization project.
Mayor Lovely Warren isn't taking it lightly that the bill, sponsored by Assemblyman Joe Morelle, was filed without the city's say.
"This is the first time that I remember something that affects the community to this magnitude not being shared with the sitting mayor before being filed. I find that to be disrespectful and I find that to be uncalled for," said Mayor Warren, D-Rochester.
Warren and City Council President Loretta Scott believe the bill is flawed and lacks necessary oversight.
The bill will authorize the $435 million for the district's Facilities Modernization Program, but the problem is what happened with the $300 million-plus allotted for phase one. The plan calls for renovating up to 25 Rochester district schools.
Warren and Scott say money was mishandled, poor decisions were made and allegedly false reports were being filed on behalf of minority and women-owned businesses. The FBI is currently investigating a lot of that.
"If you want to look back at the old ICO or the current ICO that's under investigation right now, they paid him $750,000. There�s no monetary sanction, there's no criminal sanctions in the legislation, so what is the tax payer's safeguard," said Warren.
Scott and Warren said they want changes to the bill that will provide oversight to tax payer dollars. They also want the current project manager's name cleared by the FBI before continuing on to the next phase.
"I don't believe that what the mayor has asked for is unreasonable. It does not provide a hardship for anyone; instead, it does provide protection," said Scott.
City leaders said they are in full support of the project, but think changes to the bill are necessary.
- See more at: http://rochester.twcnews.com/content/news/745415/mayor-says-bill-for-next-phase-of-modernization-in-rochester-city-schools-is-flawed/#sthash.zRwlNkHt.dpuf

domain: law