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Description: Our sterling silver bold green crystals from Swarovski earrings showcases a stunning eye-shaped crystal, sitting on a silver base. Paired with elegant silver hooks that let the crystals dangle around your ears. Showcasing its sleek finish and stunning lines perfectly, that will charm its way into your collection.
- Authentic & Verifiable Crystals from Swarovski
- Its unique 16 digit code allows you to confirm authenticity.
- Rhodium-plated pieces require slight care.
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domain: design


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Post-Traumatic Stress Disorder in Extremely Poor Women: Implications for Health Care Clinicians
To identify childhood antecedents for lifetime post-traumatic stress disorder (PTSD) and to determine how this diagnosis relates to health and service use among extremely poor women.
We conducted a secondary data analysis of 425 women in the Worcester Family Research Project, a case-control longitudinal study of 220 sheltered homeless and 216 extremely poor housed (never homeless) women in Worcester, Massachusetts.
We found that extremely poor women with lifetime PTSD were more likely to have grown up in family environments of violence, threat, and anger than those without PTSD. The strongest risk factor for PTSD was childhood sexual abuse with threat. Low-income women with lifetime PTSD had more bodily pain, even when controlling for other health and demographic factors. Women with PTSD experienced more chronic health conditions and had more problematic relationships with their health care providers and perceived more barriers to care.
Many low-income women have difficulty using medical care appropriately because of childhood histories of physical and sexual abuse, the subsequent development of post-trauma responses, and structural barriers to care. Given these factors, it is critical that health care clinicians routinely screen for histories of violence and PTSD and develop treatment plans that ensure safety, link current symptoms with prior experiences, and provide support as necessary. A team approach coordinated by a case manager may be the best strategy. Without routine screening for PTSD and sensitive treatment, many extremely poor women will receive compromised health care and may even be retraumatized. (Authors)
Type of Resource:

domain: sociology


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Moon Stone Vessel 4
Hand-built textured stoneware bottle with a detailed and multi-layered surface finish created by the interaction of oxides and white porcelain slip. Glazed interior to enable the vessel to hold liquid. Final firing to 1260 degrees C.
Dimensions: H 20 x W 13.5cms
Care Instructions: Gentle hand washing only.

domain: artistic


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Fortunately, CBD can be a great help for dogs suffering from stress and anxiety. It produces a calming effect and encourages a relaxed response, allowing your pup to feel at ease, even during a thunderstorm. If this is your first time using CBD for dogs, it's natural to want to start slowly. The amount of CBD to give your dog will depend on their size and weight; larger dogs will need more, while smaller dogs will do just as well with less.
Humans and dogs appear to respond to CBD in a similar way. CBD oil may help reduce anxiety, seizures, pain and inflammation in dogs and improve skin conditions. Research is ongoing into the potential benefits of CBD for dogs, and science may soon reveal its full potential.
CBD Dog TreatsCBD dog treats are a great way to give your pup the calming effects of CBD.
Many of these treats contain 450 mg of broad-spectrum CBD, as well as chamomile, passionflower and valerian root, L-tryptophan and GABA. Independent researchers test these products to make sure they contain the amount of CBD stated on the label. While there are some mild side effects associated with CBD, they are very rare. Cannabinoids are substances such as CBD and THC that mimic endocannabinoid chemicals naturally produced in all vertebrates.
While some veterinarians may be hesitant to suggest CBD, many are eager to discuss it once you bring it up. Broad-spectrum CBD oil contains many compounds from the cannabis plant, except for THC. A Baylor University study found that CBD was effective in reducing anxiety in dogs, especially when administered in a liposomal formulation.
The Best BrandsIf you're looking for CBD oil to help with appetite stimulation, pain and inflammation relief, anxiety or anti-inflammatory properties, these are the top 5 brands that are taking the world of dog wellness by storm: Pet Releaf, Super Snouts, Austin and Kat. The time it takes to see the benefits of these treats will depend on the ingredients and the potency level of each treat.
Full-spectrum CBD oil contains all compounds from the cannabis plant, including trace amounts of THC. After trying many other brands with no success in relieving my dog Lilly's symptoms, I did some research and discovered Holistapet. I chose products with added ingredients such as chamomile, melatonin, vitamins and L-theanine which only further enhance the positive effects of CBD. When exercising your pup with CBD treats, start slowly but keep in mind that more isn't always better; sometimes too little or too much can have an opposite effect. Many people worry about giving their dog CBD because it comes from hemp which is a form of cannabis plant.
However, hemp-derived products contain only trace amounts of THC which is not enough to cause any psychoactive effects.

domain: pet


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Revista Española de Salud Pública
versión impresa ISSN 1135-5727
GIL-SETAS, Alberto et al. Non-typhoidal salmonellosis in a basic health area of navarra, spain. Rev. Esp. Salud Publica [online]. 2002, vol.76, n.1, pp. 49-56. ISSN 1135-5727. http://dx.doi.org/10.1590/S1135-57272002000100006.
Background: Salmonella gastro-enteritis is a Zoonoses transmitted by the ingestion of food products and water or fomites contaminated by the faeces of infected people or animals. At present, constitutes a world-wide pandemic. The aim of the present study has been to in progress examine cases of non-typhoidal salmonellosis in the Health Area I of Navarra (376,079 inhabitants). Methods: 39,697 outpatient specimens submitted for culture during 1993-2000 were analysed retrospectively. Standard procedures to isolate enteropathogens were employed. The Salmonella strains were serotyped. Data was collected on age, sex, specimen date and result of culture and antimicrobial susceptibility testing for all isolates. Results: 2,924 salmonellae were isolated (7.4%) with the most frequent serotype being Salmonella Enteritidis (62%). The highest isolation rate was associated with children, particularly infants (1,117.3 per 100,000 inhabitants). Salmonella Typhimurium was typically more resistant than Salmonella Enteritidis, although resistance rates in both have increased in recent time. Conclusions: In spite of the socio-economic improvements, the incidence of gastro-enteritis asscociated with Salmonella spp. has continued to increase in recent years, mainly affecting infants, and constitutes an important public health problem.
Palabras llave : Salmonellosis; Gastro-enteritis; Microbial Drug Resistance; Salmonella Enteritidis; Salmonella Typhimurium.

domain: literature


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Discussion in 'Graphic Design Forum:' started by hankscorpio, Oct 17, 2014.
Application compatibility table - RoaringApps
Enjoy - works on Safari and Chrome only - apparently
I'm holding off on Yosemite, mainly because of the design "update" (ewww).
I weren't too keen at first but it is definitely growing on me, I'm really liking the whole subtle transparencies in the design.
Separate names with a comma.


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Useful lists of names of Mint employees exist from the 16th century onwards. But the records are especially strong from about 1900 onwards, when it becomes possible to provide summary career details for every member of staff. The Museum also holds thousands of photographs of people at work dating back to the late 19th century.
If you would like to make a family history enquiry about a former employee, or if you have a story you wish to share, please contact us using the enquiry form. As has been the case for the last 40 years or so, all correspondence relating to family history is filed alphabetically to provide a foundation for future research.
The frustration with surviving photographs very often lies in not knowing the names of those in the picture, a situation which certainly applied to the three gentlemen shown here in a photograph from the 1890s – that is, until quite recently.
We were contacted from America by a descendant of the man to the bottom-left whom we now know to be Edmund Anning. In researching her family history, the lady knew of the connection with the Royal Mint and, having bought a copy of Graham Dyer’s The Royal Mint: An Illustrated History, discovered her relative in one of the images on page 37. She subsequently made contact with the Museum, revealing who the man was, and we were able to tell her about his career at the Royal Mint as a packer and teller at the time the picture was taken and later how he moved up to the position of Office Keeper. The story provides an excellent illustration of how the Museum is able to help others with their research and how they in turn are able to enhance our knowledge of the records and images that have come down to us.

domain: library


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Your source for and about everything limited-edition, rare, one-of-a-kind, hand-made, or custom including toys, shoes, fashion, t-shirts, posters, prints, paintings, sculpture, and technology that you can't actually afford.
Tuesday, June 29, 2010
I ♥ NC!
This is why I love North Carolina. I have to get back sometime in July for these!


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Weekly animals gallery
Photos of Sakurajima volcano
On a recent visit to Japan, alien landscape photographer captured some spectacular images of in Kagoshima prefecture.
Who let the frogs out? Tiny amphibians dazzle in a ribbiting...
Photographer and reptile enthusiast Angi Nelson began taking pictures of frogs from her own collection after a diagnosis with the debilitating disease ME left her housebound.
SAVE THE FROGS!
Eleuthera Trailer v1
Marble stare-case: Teen schoolboy creates breathtaking images......
Caleb Tenenbaum, from New Jersey, only took up photography last August after seeing a photographic exhibition in which the snapper had used a crystal ball.
waves, particles, and the weight of our bodies


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|Publisher:||1st World Library|
|Product dimensions:||5.50(w) x 8.50(h) x 0.81(d)|
|Age Range:||8 - 11 Years|
About the Author
Read an Excerpt
THE CRIMSON FAIRY BOOK
By Andrew Lang, H.J. Ford
Dover Publications, Inc.Copyright © 1967 Dover Publications, Inc.
All rights reserved.
THERE was once a king's son who told his father that he wished to marry.
'No, no!' said the king ; 'you must not be in such a hurry. Wait till you have done some great deed. My father did not let me marry till I had won the golden sword you see me wear.'
The prince was much disappointed, but he never dreamed of disobeying his father, and he began to think with all his might what he could do. It was no use staying at home, so one day he wandered out into the world to try his luck, and as he walked along he came to a little hut in which he found an old woman crouching over the fire.
'Good evening, mother. I see you have lived long in this world ; do you know anything about the three bulrushes ?'
'Yes, indeed, I've lived long and been much about in the world, but I have never seen or heard anything of what you ask. Still, if you will wait till to-morrow I may be able to tell you something.'
Well, he waited till the morning, and quite early the old woman appeared and took out a little pipe and blew in it, and in a moment all the crows in the world were flying about her. Not one was missing. Then she asked if they knew anything about the three bulrushes, but not one of them did.
The prince went on his way, and a little further on he found another hut in which lived an old man. On being questioned the old man said he knew nothing, but begged the prince to stay overnight, and the next morning the old man called all the ravens together, but they too had nothing to tell.
The prince bade him farewell and set out. He wandered so far that he crossed seven kingdoms, and at last, one evening, he came to a little house in which was an old woman.
'Good evening, dear mother,' said he politely.
'Good evening to you, my dear son,' answered the old woman. 'It is lucky for you that you spoke to me or you would have met with a horrible death. But may I ask where are you going ?'
'I am seeking the three bulrushes. Do you know anything about them ?'
'I don't know anything myself, but wait till to-morrow. Perhaps I can tell you then.' So the next morning she blew on her pipe, and lo ! and behold every magpie in the world flew up. That is to say, all the magpies except one who had broken a leg and a wing. The old woman sent after it at once, and when she questioned the magpies the crippled one was the only one who knew where the three bulrushes were.
Then the prince started off with the lame magpie. They went on and on till they reached a great stone wall, many, many feet high.
'Now, prince,' said the magpie, 'the three bulrushes are behind that wall.'
The prince wasted no time. He set his horse at the wall and leaped over it. Then he looked about for the three bulrushes, pulled them up and set off with them on his way home. As he rode along one of the bulrushes happened to knock against something. It split open and, only think ! out sprang a lovely girl, who said : 'My heart's love, you are mine and I am yours ; do give me a glass of water.'
But how could the prince give it her when there was no water at hand ? So the lovely maiden flew away. He split the second bulrush as an experiment and just the same thing happened.
How careful he was of the third bulrush ! He waited till he came to a well, and there he split it open, and out sprang a maiden seven times lovelier than either of the others, and she too said : 'My heart's love, I am yours and you are mine; do give me a glass of water.'
This time the water was ready and the girl did not fly away, but she and the prince promised to love each other always. Then they set out for home.
They soon reached the prince's country, and as he wished to bring his promised bride back in a fine coach he went on to the town to fetch one. In the field where the well was, the king's swineherds and cowherds were feeding their droves, and the prince left Ilonka (for that was her name) in their care.
Unluckily the chief swineherd had an ugly old daughter, and whilst the prince was away he dressed her up in fine clothes, and threw Ilonka into the well.
The prince returned before long, bringing with him his father and mother and a great train of courtiers to escort Ilonka home. But how they all stared when they saw the swineherd's ugly daughter ! However, there was nothing for it but to take her home; and, two days later, the prince married her, and his father gave up the crown to him.
But he had no peace ! He knew very well he had been cheated, though he could not think how. Once he desired to have some water brought him from the well into which Ilonka had been thrown. The coachman went for it and, in the bucket he pulled up, a pretty little duck was swimming. He looked wonderingly at it, and all of a sudden it disappeared and he found a dirty looking girl standing near him. The girl returned with him and managed to get a place as housemaid in the palace.
Of course she was very busy all day long, but whenever she had a little spare time she sat down to spin, Her distaff turned of itself and her spindle span by itself and the flax wound itself off ; and however much she might use there was always plenty left.
When the queen—or, rather, the swineherd's daughter —heard of this, she very much wished to have the distaff, but the girl flatly refused to give it to her. However, at last she consented on condition that she might sleep one night in the king's room. The queen was very angry, and scolded her well; but as she longed to have the distaff she consented, though she gave the king a sleeping draught at supper.
Then the girl went to the king's room looking seven times lovelier than ever. She bent over the sleeper and said : 'My heart's love, I am yours and you are mine. Speak to me but once; I am your Ilonka.' But the king was so sound asleep he neither heard nor spoke, and Ilonka left the room, sadly thinking he was ashamed to own her.
Soon after the queen again sent to say that she wanted to buy the spindle. The girl agreed to let her have it on the same conditions as before; but this time, also, the queen took care to give the king a sleeping draught. And once more Ilonka went to the king's room and spoke to him ; whisper as sweetly as she might she could get no answer.
Now some of the king's servants had taken note of the matter, and warned their master not to eat and drink anything that the queen offered him, as for two nights running she had given him a sleeping draught. The queen had no idea that her doings had been discovered; and when, a few days later, she wanted the flax, and had to pay the same price for it, she felt no fears at all.
At supper that night the queen offered the king all sorts of nice things to eat and drink, but he declared he was not hungry, and went early to bed.
The queen repented bitterly her promise to the girl, but it was too late to recall it ; for Ilonka had already entered the king's room, where he lay anxiously waiting for something, he knew not what. All of a sudden he saw a lovely maiden who bent over him and said : 'My dearest love, I am yours and you are mine. Speak to me, for I am your Ilonka.'
At these words the king's heart bounded within him. He sprang up and embraced and kissed her, and she told him all her adventures since the moment he had left her. And when he heard all that Ilonka had suffered, and how he had been deceived, he vowed he would be revenged; so he gave orders that the swineherd, his wife and daughter should all be hanged ; and so they were.
The next day the king was married, with great rejoicings, to the fair Ilonka ; and if they are not yet dead—why, they are still living.
[From Ungarische Mährchen.]CHAPTER 2
ONCE upon a time there was a king who had an only son. When the lad was about eighteen years old his father had to go to fight in a war against a neighbouring country, and the king led his troops in person. He bade his son act as Regent in his absence, but ordered him on no account to marry till his return.
Time went by. The prince ruled the country and never even thought of marrying. But when he reached his twenty-fifth birthday he began to think that it might be rather nice to have a wife, and he thought so much that at last he got quite eager about it. He remembered, however, what his father had said, and waited some time longer, till at last it was ten years since the king went out to war. Then the prince called his courtiers about him and set off with a great retinue to seek a bride. He hardly knew which way to go, so he wandered about for twenty days, when, suddenly, he found himself in his father's camp.
The king was delighted to see his son, and had a great many questions to ask and answer; but when he heard that instead of quietly waiting for him at home the prince was starting off to seek a wife he was very angry, and said : 'You may go where you please but I will not leave any of my people with you.'
Only one faithful servant stayed with the prince and refused to part from him. They journeyed over hill and dale till they came to a place called Goldtown. The King of Goldtown had a lovely daughter, and the prince, who soon heard about her beauty, could not rest till he saw her.
He was very kindly received, for he was extremely good-looking and had charming manners, so he lost no time in asking for her hand and her parents gave her to him with joy. The wedding took place at once, and the feasting and rejoicings went on for a whole month. At the end of the month they set off for home, but as the journey was a long one they spent the first evening at an inn. Everyone in the house slept, and only the faithful servant kept watch. About midnight he heard three crows, who had flown to the roof, talking together.
'That's a handsome couple which arrived here to-night. It seems quite a pity they should lose their lives so soon.'
'Truly,' said the second crow ; 'for to-morrow, when midday strikes, the bridge over the Gold Stream will break just as they are driving over it. But, listen ! whoever overhears and tells what we have said will be turned to stone up to his knees.'
The crows had hardly done speaking when away they flew. And close upon them followed three pigeons.
'Even if the prince and princess get safe over the bridge they will perish,' said they ; 'for the king is going to send a carriage to meet them which looks as new as paint. But when they are seated in it a raging wind will rise and whirl the carriage away into the clouds. Then it will fall suddenly to earth, and they will be killed. But anyone who hears and betrays what we have said will be turned to stone up to his waist.'
With that the pigeons flew off and three eagles took their places, and this is what they said:
'If the young couple does manage to escape the dangers of the bridge and the carriage, the king means to send them each a splendid gold embroidered robe. When they put these on they will be burnt up at once. But whoever hears and repeats this will turn to stone from head to foot.'
Early next morning the travellers got up and breakfasted. They began to tell each other their dreams. At last the servant said :
'Gracious prince, I dreamt that if your Royal Highness would grant all I asked we should get home safe and sound ; but if you did not we should certainly be lost. My dreams never deceive me, so I entreat you to follow my advice during the rest of the journey.'
'Don't make such a fuss about a dream,' said the prince ; 'dreams are but clouds. Still, to prevent your being anxious I will promise to do as you wish.'
With that they set out on their journey.
At midday they reached the Gold Stream. When they got to the bridge the servant said : 'Let us leave the carriage here, my prince, and walk a little way. The town is not far off and we can easily get another carriage there, for the wheels of this one are bad and will not hold out much longer.'
The prince looked well at the carriage. He did not think it looked so unsafe as his servant said; but he had given his word and he held to it.
They got down and loaded the horses with the luggage. The prince and his bride walked over the bridge, but the servant said he would ride the horses through the stream so as to water and bathe them.
They reached the other side without harm, and bought a new carriage in the town, which was quite near, and set off once more on their travels ; but they had not gone far when they met a messenger from the king who said to the prince : 'His Majesty has sent your Royal Highness this beautiful carriage so that you may make a fitting entry into your own country and amongst your own people.'
The prince was so delighted that he could not speak. But the servant said : 'My lord, let me examine this carriage first and then you can get in if I find it is all right; otherwise we had better stay in our own.'
The prince made no objections, and after looking the carriage well over the servant said : 'It is as bad as it is smart' ; and with that he knocked it all to pieces, and they went on in the one that they had bought.
At last they reached the frontier ; there another messenger was waiting for them, who said that the king had sent two splendid robes for the prince and his bride, and begged that they would wear them for their state entry. But the servant implored the prince to have nothing to do with them, and never gave him any peace till he had obtained leave to destroy the robes.
The old king was furious when he found that all his arts had failed ; that his son still lived and that he would have to give up the crown to him now he was married, for that was the law of the land. He longed to know how the prince had escaped, and said : 'My dear son, I do indeed rejoice to have you safely back, but I cannot imagine why the beautiful carriage and the splendid robes I sent did not please you ; why you had them destroyed.'
'Indeed, sire,' said the prince, 'I was myself much annoyed at their destruction ; but my servant had begged to direct everything on the journey and I had promised him that he should do so. He declared that we could not possibly get home safely unless I did as he told me.'
The old king fell into a tremendous rage. He called his Council together and condemned the servant to death.
The gallows was put up in the square in front of the palace. The servant was led out and his sentence read to him.
The rope was being placed round his neck, when he begged to be allowed a few last words. 'On our journey home,' he said, 'we spent the first night at an inn. I did not sleep but kept watch all night.' And then he went on to tell what the crows had said, and as he spoke he turned to stone up to his knees. The prince called to him to say no more as he had proved his innocence. But the servant paid no heed to him, and by the time his story was done he had turned to stone from head to foot.
Oh! how grieved the prince was to lose his faithful servant! And what pained him most was the thought that he was lost through his very faithfulness, and he determined to travel all over the world and never rest till he found some means of restoring him to life.
Now there lived at Court an old woman who had been the prince's nurse. To her he confided all his plans, and left his wife, the princess, in her care. 'You have a long way before you, my son,' said the old woman ; 'you must never return till you have met with Lucky Luck. If he cannot help you no one on earth can.'
So the prince set off to try to find Lucky Luck. He walked and walked till he got beyond his own country, and he wandered through a wood for three days but did not meet a living being in it. At the end of the third day he came to a river near which stood a large mill. Here he spent the night. When he was leaving next morning the miller asked him : 'My gracious lord, where are you going all alone ?'
And the prince told him.
'Then I beg your Highness to ask Lucky Luck this question: Why is it that though I have an excellent mill, with all its machinery complete, and get plenty of grain to grind, I am so poor that I hardly know how to live from one day to another ?'
The prince promised to inquire, and went on his way. He wandered about for three days more, and at the end of the third day saw a little town. It was quite late when he reached it, but he could discover no light anywhere, and walked almost right through it without finding a house where he could turn in. But far away at the end of the town he saw a light in a window. He went straight to it and in the house were three girls playing a game together. The prince asked for a night's lodging and they took him in, gave him some supper and got a room ready for him, where he slept.
Next morning when he was leaving they asked where he was going and he told them his story. 'Gracious prince,' said the maidens, 'do ask Lucky Luck how it happens that here we are over thirty years old and no lover has come to woo us, though we are good, pretty, and very industrious.'
The prince promised to inquire, and went on his way.
Then he came to a great forest and wandered about in it from morning to night and from night to morning before he got near the other end. Here he found a pretty stream which was different from other streams as, instead of flowing, it stood still and began to talk : 'Sir prince, tell me what brings you into these wilds? I must have been flowing here a hundred years and more and no one has ever yet come by.'
Excerpted from THE CRIMSON FAIRY BOOK by Andrew Lang, H.J. Ford. Copyright © 1967 Dover Publications, Inc.. Excerpted by permission of Dover Publications, Inc..
All rights reserved. No part of this excerpt may be reproduced or reprinted without permission in writing from the publisher.
Excerpts are provided by Dial-A-Book Inc. solely for the personal use of visitors to this web site.
Table of Contents
The Hairy Man
To your Good Health!
The Story of the Seven Simons
The Language of Beasts
The Boy who could keep a Secret
The Prince and the Dragon
Tiidu the Piper
The Gifts of the Magician
The Strong Prince
The Treasure Seeker
The Cottager and his Cat
The Prince who would seek Immortality
The Gold-bearded Man
"Tritill, Litill, and the Birds"
The Three Robes
The Six Hungry Beasts
How the Beggar Boy turned into Count Piro
The Rogue and the Herdsman
The Death of Abu Nowas and of his Wife
Niels and the Giants
How the wicked Tanuki was punished
The Crab and the Monkey
The Horse Gullfaxi and the Sword Gunnföder
"The Story of the Sham Prince, or the Ambitious Tailor"
The Colony of Cats
How to find out a True Friend
The Magic Kettle


When it ain’t broke, there’s no need to fix it. At least that’s what Sarah Crawford of Broma Bakery believes. The bakery blogger reminded her 519,000 IG followers of a 2021 post that saved the dessert tray this past Christmas and just may do the same this upcoming holiday season. This easy crowd pleaser? Snickerdoodle Blondies with bourbon.
The recipe is as simple as it looks, using everyday pantry (and liquor cabinet) items, including unsalted butter, granulated sugar, egg, flour, salt, and cinnamon. One special ingredient, cream of tartar, is really the most important — which Crawford credits for bringing rise to the brownies and the characteristically tangy Snickerdoodle-y flavor. The final step features a splash of bourbon whiskey, a sugar-cinnamon sprinkle on top, and a quick bake in the oven, before you have yourself the perfect blondie.
“I know it’s cookie season, but blondies are a lazy girl’s best friend. They are super chewy, perfect for a crowd, and so easy to make,” she wrote on her blog. These beauties take roughly 45 minutes from start to finish and taste incredible when you snack on them warm.
If they last that long (which they won’t), you can keep them on your counter for up to four days or freeze them in a sealed baggie for up to three months. And don’t be afraid to make them your own. “If you’re feeling adventurous, add some butterscotch or chocolate chips to the batter to take it up a notch,” she wrote. “I bet that’d taste amazing.”


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EASY STUFFED SHELLS
1 container ricotta cheese
1/4 cup grated Parmesan cheese
2 1/2 cups shredded mozzarella cheese (reserve 1/2 cup for topping)
1 package jumbo shells
2 TBSP parsley
1 tsp pepper
1 tsp salt
1 jar marinara sauce
Cook jumbo shells according to package directions.
Combine ricotta, Parmesan, 2 cups mozzarella, and seasonings. Set aside.
Lightly spray a 9x13 baking dish. Spread 1/2 cup marinara sauce in a thin coat along the bottom. Stuff shells with cheese mixture and place open side up in the baking dish. Evenly pour remaining marinara on stuffed shells and sprinkle with the last 1/2 cup grated mozzarella. Bake uncovered at 350 Degrees F 20-30 minutes, or until bubbly.
This can be made the night before and refrigerated until cooking. Baking time will increase.
The stuffed shells can also be layered in a crock pot and cooked on low 2-4 hours.

domain: food


Development of a Feedback Controlled Carbon Nanotube-Based Nanoelectromechanical DeviceChanghong Ke, Ph.D., Northwestern University, 2006.
Major Professor: Dr. Horacio D. Espinosa.
This dissertation presents the development of a feedback controlled carbon nanotube based nanoelectromechanical device. The device consists of a cantilevered multi-walled carbon nanotube (MWNT) clamped to a top electrode and actuated by a bottom electrode. The actuation circuit also includes a source and a feedback resistor. The pull-in/pull-out and tunneling characteristics (I-V) of the system are investigated by means of electromechanical analysis and in-situ scanning electron microscopy (SEM) measurement. The electromechanical model takes into account various aspects of mesoscopic interactions including the effects of concentration of electrical charges, at the end of the nanocantilever, finite kinematics, van der Waals force and tunneling contact when the free end of the nanocantilever touches the bottom electrode. Based on the energy method, a close-form formula to predict the pull-in voltage of the device is derived and verified by in-situ SEM measurement. Both experiments and modeling show that the device has two well-defined stable equilibrium positions and the pull-in/pull-out processes together with these two stable equilibrium positions form a hysteretic loop.
The fabrication of individual devices has been demonstrated by the means of the nanomanipulation of individual carbon nanotubes, together with MEMS micro-fabrication. Fabrication of massively parallel device array based on directed self-assembly approach is also discussed.
The unique bistability behavior and tunneling gap of the device offer tremendous opportunities in the fields of nanoelectronics and sensors. The potential application of the device includes NEMS switches and random access memory elements, logic devices, sensor for ultrasonic wave detection and gap sensing.


GALVESTON, TX — Arguing that the hvacr contracting industry should not allow itself to be defined by its lowest common denominator, the chief elected officer of a nationally recognized contracting association challenged the industry to “Stand up to the unscrupulous contractors who would rather steal a quick buck than build a business relationship.”
In candid remarks before the Texas Air Conditioning Contractors Association (TACCA) Annual Conference, Larry Taylor, 2001-02 national president of the Air Conditioning Contractors of America (ACCA), issued a three-pronged challenge to America’s hvacr contractors, urging them to remember that small businesses are the foundation of the nation’s freedom.
“We still believe in the American dream because we see it come true every day,” Taylor said. “The notion that one person can one day open a business and grow it, prosper in it, just because he or she wants to and is determined to see it succeed — that is a notion foreign to the terrorists and many other countries of the world.
“It is the notion that makes America what it is today. It is the notion that will make America what it is in the future.”
United We Stand (You Finish The Rest)Taylor, a Texas resident and president of AirRite in Fort Worth, praised his fellow contractors for their service to America and modern life. But he issued a warning: “While we are united as Americans, it is clear — and has been clear for some time — that we are not united as an industry.”
Contractors must “reverse the process” in which they find their industry losing credibility with the buying public, Taylor said.
“There are some contractors out there who do not deserve to be in business,” he said. “They lie to their customers. They inflate their prices. They provide unnecessary services and claim to have provided some services that they have not.
“I am not surprising any of you with this admission,” Taylor said. “It is also true that these contractors are the minority. That is no surprise to you, either. However, like any industry, we are all judged based on the actions of the lowest common denominator among us.”
To counter the potential loss of credibility, contractors should embrace a solution that “has been right in front of us for a long time,” Taylor said.
Training Above All“We must all accept training costs as a necessary part of business, make it part of our business plans, and make successful completion of training as much a part of employee evaluation as anything else.
“Some people complain about the quality of training, or its accessibility. They have valid concerns. But the answer is not to throw up our hands and wait for good, accessible training to come along. We must take charge of it and create programs that meet our needs.”
Taylor continued, “We must embrace NATE certification. It is not enough to certify one of your technicians. If we are to convince the homeowners and facility managers of America that our technicians are professionals, then we have to prove it. Show that they are [certified] professionals who meet the quality standards of the industry nationwide.”
Finally, Taylor urged reputable contractors nationwide to “Embrace ACCA membership. I mean ‘one ACCA’ — the ACCA that exists in local chapters, state chapters, and the national organization.
“My business is better today because of what I have learned from other members nationwide,” he said. “I serve my customers better today because of what I have learned from ACCA. And I make more money today because of my membership.
“While we must provide training for our technicians, we must also get training ourselves — not only through formalized education but, sometimes more valuably, from the informal mentoring and knowledge sharing of ACCA.”
According to Taylor, if all reputable contractors embraced these initiatives and acted on them, “then we would go a long way toward restoring our credibility,” he said.
“It is incumbent on those of us who believe in this industry, and who take seriously our responsibilities to the public and to our customers, to ... force the lowest common denominator to either rise up to our standards of service, or drive them out of business.”
Taylor concluded, “Just like this great country, when we stand up together, united, there is nothing we can’t do. There is too much talent, too much wisdom, too much determination in the hvacr contracting industry, to allow room for failure. All we have to do is act.”
Sidebar: Contractors Respond To Mini-PollTACCA contractors responded to a “snap poll” regarding the biggest concerns they face today. The top responses are listed below.
Sidebar: Highlights of TACCA Idea SessionJosh Kahn, vice president of the Texas ACCA (TACCA), asked participants to share some ideas that have worked in their businesses — and rewarded each with a $5 or $10 bill. Here were some of the suggestions:
Publication date: 11/05/2001


Prince Buaben: I left Carlisle Utd to make it to World Cup
Last updated at 12:17, Monday, 03 February 2014
Prince Buaben has claimed that he left Carlisle United because playing in League One was damaging his World Cup ambitions.
The Ghana midfielder played for 83 minutes for Patrick Thistle in their 1-1 draw with Dundee United after joining the Scottish Premiership club on loan for the rest of the season.
That came after Blues boss Graham Kavanagh claimed Buaben had been dispatched north of the border due to disciplinary issues including being late for training.
The 25-year-old, though, says his international hopes were behind his move.
“Myself and my agent have been speaking to the Ghana manager Akwasi Appiah and he told me I need to be playing at a good level to have a chance of going to the World Cup,” Buaben said.
“The Ghana manager says I need to be playing in the top flight. I don’t mean any disrespect to League One in England but this is the Scottish Premiership. I want to go to the World Cup. I know the manager likes me and always phones my agent to see how I’m progressing.”
Buaben added to the Daily Record: “I spoke to Michael Essien and he told me to keep focused – even though we play in the same position, he always encourages me.”
Another United loanee, Mark Beck, was a second-half sub for Falkirk in their 1-1 draw with Scottish Championship bottom side Morton.
Striker Beck came on in the 59th minute to partner ex-Blues frontman Rory Loy, who earlier had a penalty saved for the Bairns.
First published at 11:12, Monday, 03 February 2014
Published by http://www.newsandstar.co.uk
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|NEWS & STAR ON:|
- Council tax to rise as Carlisle tries to cope with cuts (35 comments)
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The waves at Ocean City were awesome yesterday. They were the cleanest waves I've seen there although they were closing out for the most part. I got some great rides in and spent almost two hours in the water surfing. It was a good day.
Simon even got one good picture of me surfing. Although I can't find my connector cord for my camera so I will have to post them later when it turns up.
I'm off to brunch with a friend and then off to a focus call at one of the theaters here in philly so my day is packed.

domain: hobby


text: Oh my days, this is rank. Earlier this year I was bitterly disappointed by a favourite author when Jo Nesbo churned out Macbeth. Now Jussi Adler-Olsen has done the same. I‘ve devoured his Department Q series and was pleased to see him trying something different, stand-alone. Sadly it is the most far-fetched, poorly imagined, meandering tale you could hope to find. Every lightweight strand of plot is unconvincing. So disappointing.


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President Trump Speaks On Terror Attack
President Donald Trump called the murderous spree by a rental truck driver in New York City on Tuesday "another attack by a very sick and deranged person," sent condolences to victims of what the president referred to as a "terrorist attack," and pledged to step up extreme vetting of those seeking to enter the U.S.
Trump warned in a tweet after being briefed by his chief of staff John Kelly: "We must not allow ISIS to return, or enter, our country after defeating them in the Middle East and elsewhere. Enough!" His tweets below...
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Coan Payton & Payne announced today that Ryan Heatherman has joined the firm.
Heatherman’s practice focuses on business and banking litigation, business transactions and corporate contracts, business formation, mergers and acquisitions, corporate and regulatory compliance, all areas of real estate, oil and gas related issues, insurance coverage, creditors’ rights, judicial foreclosures, employment issues, estate and probate
administration, family law, and military law. Heatherman is admitted to practice before all courts in Colorado, Oklahoma, and the Court of Appeals for the Armed Forces.
Heatherman received his Bachelor’s of Business Administration from the University of Oklahoma. He then received his law degree from the University of Tulsa College of Law.
He started his career as an Officer in the United States Marine Corps, where he prosecuted courts-martial and later deployed to Afghanistan with an infantry battalion.
After the Marine Corps, Heatherman served as the general counsel of an oil and gas company for two years, before enrolling at the University of Notre Dame, where he received a Master’s of Business Administration.
Before joining CP2, Mr. Heatherman moved to Fort Collins with his wife and children and founded a litigation law firm. He continues to serve as a Major in the United States Marine Corps Reserves and is on the Executive Board of Colorado Lawyers for Colorado Veterans.

domain: law


All right brother. Eid has gone to mind. Everything is silent.
Why would some people speak on camera?
No one is speaking brother. Everyone has something or the other in their mind. No one will say anything. Many media persons are roaming around since last Saturday. But visit Chakia, Rajrooppur, Khuldabad, Beniganj, Karbala, Himmatganj, Roshanbagh… so many localities. No one will say anything. Everyone has something or the other in their mind. But everyone is silent. Everyone knows that if someone says something anti-shunt, the police will pick it up as soon as they see the video.This is what a Muslim man says on the road leading to Lukarganj in Prayagraj’s Chakia locality. Some 2 km from this locality a road leads to the cemetery of Kasari Masari. On the other side is Dhumanganj police station. After 7 o’clock in the night, an old man standing here says – are you a media person? Where have you come from? If you are from Delhi and are from such and such channel, then don’t go that way. You have an ID card, don’t you? Then go for a walk. But it is better if you go during the day. People are angry with the media, will argue at night, may be, show anger too. Even if there is a fight, it is not a big deal.
‘This is not Patna, Atik will go away saying Zindabad’
This trend is everywhere. Atala, Kareli, Chakia, Kasari, before going to Masari everywhere, on calling a local person, people say that nobody will say anything. A journalist of a newspaper in Prayagraj and a person living in the same locality says- See, even those who tried to say something wrong after the Atiq-Ashraf incident, were hanged by the STF and the police as soon as the video went viral. . This is not Patna, where you will raise slogans after the prayers of goodbye and lie happily at home after the video is played. Atiq’s public support is on one side, but the government is hyperactive. If there is a possibility of something happening here and there, then the police is taking the leg.
Anger among the Muslims of Gaddi against the media
Local journalist Shivpujan Singh, who lives in Prayagraj, says- Look sir, there is anger about the media. Off record people are even saying that media people killed Atiq Bhai’s day. But then you are asking – are you still doing the record? Another person, on the condition of not writing his name, says, ‘Those areas of Prayagraj where people have sympathy for Atiq, some of them are called the areas of Gaddi Muslims. Atiq was from his community. These people say – this time the throne is only one…. Even when Atiq’s Jaun was doing Khilafat, they have become one. There is fear of force and government. Demonstrations took place in Atala after Nupur Sharma’s statement, but as the JCB is running, people are scared to see all that. But it is certain that after the death of Atiq, the Muslim community has definitely become one. Whatever the effect. At the moment everyone is calm.
Police officers were also seen avoiding the media
The NBT team tried to talk to the police officers on the whole situation in Prayagraj. On Sunday, an attempt was made to talk to several police officers from the Commissioner of Police to the lower level on their CUG numbers in this regard. However, all the police officers were seen avoiding talking to the media. On some numbers the PRO picked up the phone and asked to talk to such and such officer. On the other hand, the public relations officers of some officers said that they deliver the message. Sir will talk to you if needed.
: Language Inputs
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Buffalo Fish Stick Sandwich.
You can cook Buffalo Fish Stick Sandwich using 11 ingredients and 7 steps. Here is how you achieve it.
Ingredients of Buffalo Fish Stick Sandwich
- You need of Sandwich—————-.
- You need 9 slices of fish sticks frozen.
- You need 2 slices of bread.
- Prepare As needed of oil to fry in shallow fry.
- Prepare of Tarter sauce——————.
- Prepare 1/3 cup of mayonnaise with cracked black pepper.
- You need 1 teaspoon of dill weed.
- Prepare 1 tablespoon of finely diced onions.
- Prepare of Buffalo sauce—————.
- It’s 2 tablespoons of butter melted.
- It’s 1/4 cup of your favorite hot sauce I used Crystals.
Buffalo Fish Stick Sandwich instructions
- Get the oil hot. Fry the fish sticks till done and crispy. Move to a paper towel to absorb excessive amounts of oil.
- Mix the butter and hot sauce.
- Dice the onion and add to the cracked black pepper mayonnaise. Add the dill weed and mix well.
- Spread the tarter sauce on the bread slices..
- Add the Buffalo sauce to the fish sticks..
- Put the Buffalo sauce coated fish sticks on the bread.
- Serve I hope you enjoy!.


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A baby gorilla that was the first to be born by Caesarean section in Britain is celebrating her second birthday.
Afia, a western lowland gorilla, is now fully integrated into her primate family after being hand-reared by zookeepers in Bristol.
She was born by emergency C-section in February 2016 after her mother, Kera, showed symptoms of potentially life-threatening pre-eclampsia.
The operation was carried out by consultant surgeons from Bristol University along with the Bristol Zoo's own vet team.
Staff at the zoo say the fact Afia had a complicated early life is a reason to celebrate as she turns two.

domain: news


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[vodpod id=Video.12926471&w=540&h=350&fv=%26rel%3D0%26border%3D0%26] Wiz Khalifa’s Rolling Papers tour made its way to Masquerade in Atlanta last night. Exclusive Access was in the crowd and grabs footage of Wiz and Big Sean’s performances.
Tag: big sean
Not sure where this track will end up or who it belongs to for that matter, but here’s something new from Wale, Sean and Bobby Ray. UPDATE: Song belongs to DJ Holiday off his project, We Working EP.
[vodpod id=Video.12526171&w=540&h=350&fv=%26rel%3D0%26border%3D0%26] Sean is currently traveling the US on Wiz’s Rolling Papers tour, and during the Houston stop, he brought out Kirko Bangz and Bun B to perform their collabo, “What Yo Name Iz (Remix)”. wkbs via onenecktwochains Update: Bun catches a flick during Wiz’s set.
[vodpod id=Video.12469455&w=540&h=350&fv=] Big Sean began shooting visuals for his new single, “Marvin Gaye & Chardonnay” last night with Kanye West. Sway caught up with Sean as he spoke on what to expect from the final product. Finally Famous in stores now. Sidebar: Big Sean Speaks With Funk Flex
It’s been a good week for both Bey and Big Sean. After seven days, Beyoncé’s 4 tops the Billboard charts after moving 310,669 copies. Meanwhile, Big Sean’s Finally Famous takes the bronze medal with 87,331 units scanned. Congrats!
[vodpod id=Video.12029560&w=540&h=350&fv=%26rel%3D0%26border%3D0%26] Bootleg Kev recently chopped it up with Big Sean out in Las Vegas. Sean speaks on performing at this year’s BET awards, Kanye West’s production missing on the album, and a lil’ bit of everything in between. Finally Famous is in stores now.
[vodpod id=Video.12000108&w=540&h=350&fv=] Eric: What’s your favorite bird? Jeff: A Basketball Wife Jeff and Eric Rosenthal posted up at the red carpet during last weekend’s BET Awards. In the first clip, the pair run into DJ Drama, Rick Ross, Big Sean, and more. Funny stuff. mtv

domain: entertainment


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Emperio Yachting is the “one stop shopping” yacht service company when visiting Greece.
Operated by renowned ex yacht Captains, Emperio Yacht Agency department provides a range of indispensable yacht services in Greece and East Med. As yacht agents and managers specialising in large yachts, both private & charter, we offer a fully comprehensive range of services, handled by a well-trained and experienced team.
Our Headquarters are located in Athens Greece with an agent at every port. Emperio experienced support team will respond to your needs quickly and professionally.
Even before the arrival, the yacht will benefit from our itinerary and clearance advice tailored made to the Guests’ lifestyle and local weather .
Our invaluable assistance continues for the duration of the yacht’s trip through the islands, until they clear you out to your next country .
Emperio Yachting services include legal advise, technical support, customs and immigration clearance, concierge services, berth bookings, provisioning, flag/ class inspections as well as cruising permits.

domain: travel


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Tecmo Super Bowl
Play with real NFL teams and use real NFL players of 1990-91 NFL season in this classic retro football game – Tecmo Super Bowl! Play this fast-paced football simulator with all 28 teams from the National Football League circa 1991.
Tecmo Super Bowl is a classic sports video game released for the Nintendo Entertainment System (NES) back in 1991. In this game, the player is provided with options for NFL Preseason, Season Game, and Pro Bowl play. The game was the very first game to have licensing privileges with both the league of National Football and National Football League Players Association, thus allowing the game to use real names and attributes of the players and teams. In addition, the game features full-length 1991 NFL regular season schedule and play-off format.
Click inside the screen to activate controls
Arrow Keys – Directional Buttons / Movement
Press “Z” Key – A button
Press “X” Key – B button
Space – Select
Enter – Start
There have been 47 likes from 56 votes (84%) in ratings.
You are currently playing Tecmo Super Bowl game for free on Arcade Spot. It is a single game out of a variety of games that you can play on Arcade Spot. Play more games like Tecmo Super Bowl in the Arcade, Sports, Emulator, and NES gaming categories. This game has a rating of 84 out of 100 based on 56 user ratings. If you enjoyed playing the game then give it a thumbs up. You can also play similar games such as Tecmo Super NBA Basketball and Tecmo NBA Basketball as shown above. Arcade Games and Free Online Games are added every day. Arcade Spot will bring you the best games without downloading and a fun online gaming experience on the internet.


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Herald news services
SEATTLE — Seattle Storm guard Sue Bird won’t be playing in Everett on Saturday.
The WNBA team announced Tuesday that Bird needs arthroscopic surgery on her left knee and will be out indefinitely.
The Storm open their 2019 season Saturday at Angel of the Winds Arena in Everett.
The 11-time All-Star has a loose body in her left knee, the team said. She will undergo surgery in Connecticut in the near future.
The news about Bird is the third significant setback for Seattle in recent weeks. Reigning league MVP Breanna Stewart is out for the season after tearing her Achilles tendon playing overseas. The status of head coach Dan Hughes also is uncertain. He underwent surgery to remove a cancerous tumor in his digestive tract.
Fansided.com first reported on Bird’s surgery. Bird did not play in either of Seattle’s preseason games.

domain: medical


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ExxonMobil and Invista pay for TCEQ Violations
Two Southeast Texas companies, ExxonMobil and Invista, were hit with fines for air pollution violations from the Texas Commission on Environmental Quality (TCEQ) amounting to a combined total of $100,626.
This was part of a larger statewide effort by the TCEQ. According to the agency, a total of 42 regulated entities were fined $540,711 for a variety of violations.
ExxonMobil’s Beaumont refinery at 1795 Burt St. was fined $87,500 for one air pollution incident, according to agency records.
TCEQ records show the refinery failed to prevent the unauthorized release 30,405.55 pounds of volatile organic compounds and 33.96 pounds of sulfur dioxide from a vapor line that started Oct. 12, 2012, and lasted 190 hours — two hours shy of eight days. The chemical plant released 14 pounds of hydrogen cyanide in 16 minutes Oct. 12.
The release occurred as a result of corrosion on an inlet nozzle on a caustic scrubber, according to the agency. ExxonMobil replaced the nozzle and modified the equipment as of Feb. 17, 2013, to mitigate future leaks and to prevent recurrence of emissions.
TCEQ fined local chemical plant Invista SARL, located at 3055 FM 1006 in Orange, $13,126 for two emissions events that resulted in the release hydrogen cyanide.
According to agency records, on Oct. 10, 2012, Invista SARL released 14 pounds of hydrogen cyanide in 16 minutes after a valve became locked in a partially open position during a maintenance turnaround. The company released 20 pounds of hydrogen cyanide and 350 lounds of carbon monoxide in four hours, eight minutes on Dec. 1, 2013, when plant operators failed to maintain required nitrogen pressure as a unit in the plant was restarted.
Actions have been taken by the plant, TCEQ records show. March 13, 2013, the plant revised procedures and implemented training to prevent future emissions events.
Both companies have TCEQ enforcement actions still pending, according to state records.

domain: chemistry


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Apr 10, 2017 · Ever since people discovered that THC is the cannabinoid responsible for the (AMAZING) psychoactive effects of cannabis, scientists have been trying to isolate this compound and develop strains that contained higher and higher amounts of THC. These days though, CBD and the other cannabinoids in cannabis are sharing the spotlight. What Is THC-A? | POPSUGAR Fitness Jun 24, 2018 · "THC-A has many of the anti-inflammatory properties of both CBD and THC, but unlike those two, it can only be accessed through fresh cannabis leaves," Miss Grass cofounder and editor in … THC Direct – The Best Products at the Best Prices The Best Products at the Best Prices
THC / Dispensary Referral Form for Patients; Patient Generated Reviews (5-Star System) About THC. The Healing Clinic is a full service Medical Marijuana Patient Advocacy center. We are a group of doctors and medical marijuana Patient Advocates here to serve Chicago and the surrounding areas.
Mounting evidence shows ‘cannabinoids’ in marijuana slow cancer growth, inhibit formation of new blood cells that feed a tumor, and help manage pain, fatigue, nausea, and other side effects. Rostlina konopí obsahuje mnoho kanabinoidů. Již dlouhou dobu je nejznámější tetrahydrocannabinol (THC). V poslední době se ale snahy vědců a lékařů ve výzkumu konopí zaměřují na další kanabinoidy, obzvláště na cannabidiol (CBD), který v sobě… Both CBD and THC may have benefits, but they differ despite their similarities. Learn the difference between these two cannabis components. Nejnovější tweety od uživatele CBD.THC (@Cbdthc2). #exotic #exoticgas #whiteruntz #pinkruntz #runtzOG #gushers #plushers #ballanerries #brasknucles #smartcarts #kingpen #dankwoods #packwoods #backwoods #dankvape. In the ongoing efforts to legalize marijuana for medicinal and therapeutic purposes, you may hear the terms “CBD” and “THC” and think they are one and the same. While both are found in the same plant genus (cannabis, which includes both…
Home / Category / THC Free THC Free. Filter Products Showing the single result Sort By None Popularity Average rating Newness Price: low to high Price: high to low. sale and distribution of our CBD Oil products. The link does not constitute an endorsement of these organizations by CBDGum.NetworkofHemp.com, and none should be inferred.
The link provides additional information that may be useful or interesting and has no affiliation to the promotion, sale and distribution of our CBD Oil products. The link does not constitute an endorsement of these organizations by BuyHempCBDOil.com, and none should be inferred. THC-A Isolate (HDC) : Product Descriptions, Reviews and THC-A isolate, just the name alone can cook the person. This stuff is unlike anything else and a real game changer. Pro tip is to use smalls amounts mixed with other concentrates, this way you don’t shoot up your tolerance and it will last much longer. THC, THCA, CBD, CBC, CBN: Medical Marijuana Composition
16 Oct 2018 "Most sublingual formulations of THC or CBD cannabis products, such How to take it: Topically, by rolling the stick on your sore muscles no
THC, THCA, CBD, CBC, CBN: Medical Marijuana Composition Apr 11, 2014 · THC, THCA, CBD, CBC, CBN: Medical Marijuana Composition, The Chemicals in Cannabis April 11, 2014 Medical Marijuana As the science of medical cannabis develops, we’re discovering more and more that breeding cannabis for different levels of medicinal compounds—known as cannabinoids—makes the medicine better for treating specific ailments . Scientists Develop THC-Free Cannabis Strain


The construction industry is changing worldwide as the digital technology has taken over it. The engineering, design and architecture aspect of the construction industry is getting dominated by many new technologies.
We have listed down new technologies used in construction for you.
1. Pegasus Two for survey
Land survey can take months through manual mode. But you need this 100 percent accurate data through this as the future of whole project depends on it. The surveys for large project can even take years. Pegasus Two system is made by Leica Geosystem. The vehicle conducts high definition scanning though its mounted equipment. The vehicle is capable of conducting 360-degree survey at the speed of 50 miles per hour.
Drone technology has also invaded the surveying domain in the construction space. remotely operated multirotor aircrafts are being used to conduct surveys. Digital camera mount is helping builders to achieve better results along with advanced software.
2. 3D printing enters in construction
The 3D printing technology is changing the world as we know it. The 3D printing technology is helping the engineers to create better prototypes. Many tests can be easily conducted on the 3D models of building in few hours. The process used to take days before the invention.
3. Glowing paint and stones
These glowing objects are becoming universal indicators of traffic and many other things. People are calling it ‘smart’ highways. The bicycle path is being differentiated using glow in the dark stones. The future applications of this technology will involve traffic markings and warnings to drivers.
4. Green constructions
Developers are making green buildings and practices there ultimate selling point. This also helps to decrease carbon footprint when activists all over the world are warning about the signs of global warning.
5. Roads as energy source
It is one innovative source of energy found by the construction industry. The Italy based underground power has managed to develop a technology which will convert the kinetic energy of automobiles on the road to electricity. If properly installed on right highways, this technology will produce power of 19 tons of oil. Solar roads are being constructed as well.
6. Smaller the better home
People across the globe are embracing smaller homes now. Nobody is dreaming of big rooms and huge apartment. Instead of that, people want more open green spaces. Governments are also considering this option for affordable housing.
7. Building information model
Contractors, engineers, architects and builders are taking help of this new technology. This software keeps the security or management of the building informed about the corridors in the structure. It also integrates security camera footage, electricity flows along with sewage mechanisms.
8. Google’s spatial data analyzer Project Tango
You don’t have to carry bulky CPUs and machine on the construction sites anymore. The big data obtained from the construction. Using project Tango software, smartphones and tablets can process the data collected during the site survey.
In future, construction industry in expected to introduce many revolutionary technologies to make the process simplified, fast and green.


toilet repair parts (9) toilets and bidets (14) Price. Custom price range. ... Mansfield Tank to Bowl Kit Rubber . 0 Reviews $ Free Store Pickup Today.
Many Kohler toilet tank lids already have a label and diagram with the basic replacement parts. For my toilet, Amazon sells the standard Kohler fill valve for $14.99. The flush valve is sold separately for $17.45, and the flapper is again separate for around $8. In comparison, a Fluidmaster 400 flapper and fill valve kit is only $10.
Jun 08, 2009 · If i were you. i go to a plumber supply house and get the best Mansfield's Rubber flap. Change it in 30 sec and be done. I own and maintain 14 units of apt. 8 of those are mansfield. i make stupid mistake in changing one of the drain tube into universal drain tube. Now the flush handle has to be jerry rigged. Filling tube could be change to ...
Mansfield Toilet Tank Numbers. Click Below On The Tank Number Found In Your Tank
How to mend anything. Free repair help D.I.Y, Toilets - toilet mansfield 160.
How To Repair An RV Toilet To repair your RV toilet, follow these steps: The first step is to turn off the water pressure — either by turning off the “City Water” valve or turning off the on switch for the on-board water pump. Flush the toilet to bleed off any remaining water pressure and to empty all water out of the toilet bowl.
Toilet Repair Parts for all Brands. Ready for immediate shipment. On sale now at PPL's RV Parts Superstore. Great Prices!
If any of these parts is faulty, water will flow out past the plunger continuously, and the toilet will run constantly. Examine all of the washers and replace any defective ones. Step 3: If the ballcock assembly is sealed, replace it as a unit. Shut off the toilet water supply at the shutoff valve and flush the tank.
Find Mansfield toilet parts & repair at Lowe's today. Shop toilet parts & repair and a variety of plumbing products online at Lowes.com.


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Tri-State Veterinary Services LLC, a completely mobile large animal veterinary practice serving the CT, MA, and NY tri-state area. Owned by veterinary practitioner Dr. Lisa Dauten, we provide veterinary services to cattle, swine, equine and small ruminants/camelids. If you are looking for veterinary services for your livestock or large animal companions, please contact Tri-State Vet with any questions or to schedule an appointment in the new year.
Monday & Tuesday: 7:00 a.m. – 5:00 p.m.
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The gut of your horses requires a fine balance of
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Recently we got the great news that we were awarded funding from NASA’s Office of Chief Technologist for the NASA Innovative Advanced Concept (NIAC) proposal “Super Ball Bot – Structures for Planetary Landing and Exploration.” The proposed research revolves around a radical departure from traditional rigid robotics to “tensegrity” robots composed entirely of interlocking rods and cables. Out of more than 600 white papers originally submitted, this proposal is one out of only 18 that were funded for 2012. Tensegrities, which Buckminster Fuller helped discover, are counter-intuitive tension structures with no rigid connections and are uniquely robust, light-weight, and deployable. Co-led by Vytas SunSpiral (Intelligent Robotics Group) and Adrian Agogino (Robust Software Engineering Group), and collaborating with David Atkinson of the University of Idaho, the project is developing a mission concept where a “Super Ball Bot” bounces to a landing on a planet, then deforms itself to roll to locations of scientific interest. This combination of functions is possible because of the unique structural qualities of tensegrities which can be deployed from small volumes, are lightweight, and can absorb significant impact shocks. Thus, they can be used much like an airbag for landing on a planetary surface, and then deformed in a controlled manner to roll the spacecraft around the surface to locations of scientific interest.
These unusual structures are hard to control traditionally so Vytas and Adrian are experimenting with controlling them using machine learning algorithms and neuroscience inspired oscillatory controls known as Central Pattern Generators (CPG’s). Adrian’s work on multiagent systems and learning provide robust solutions to numerous complex design and control problems. These learning systems can be adaptive, and can generate control solutions to complex structures too complicated to be designed by hand. This approach is well suited for tensegrity structures which are complex non-linear systems whose control-theory is still being developed. Vytas has been researching robotic manipulation and mobility for over a decade and in recent years has been focused on the game-changing capabilities of tensegrity robots due to their unique structural properties. His quest to tap their potential has lead him to investigate oscillatory control approaches from the field of neuroscience, such as Central Pattern Generators (CPG’s), which show promise for efficient control of these robots.
While the Super Ball Bot project has just started, we already have some exciting initial results from the machine learning efforts. During the last year, Vytas led the development of a physics based tensegrity simulator built on-top of the open-source Bullet Physics Engine. We have been using that simulator to explore novel tensegrity structures and control approaches, and will write a separate post about the oscillatory control of a snake-like tensegrity robot and its ability to traverse many complex terrains with fully distributed control algorithms. For NIAC we are now using this simulator to test mission related properties of tensegrities. The following video shows two drop tests where we simulate a tensegrity robot landing. The results confirm what we see in physical models in our lab, which is that these structures do a great job absorbing impact forces, even as we vary the stiffness of the strings.
Since the NIAC proposal was awarded, we have focused on evolving the motion controls of a rolling tensegrity robot and have early simulation results which show it safely rolling through a rocky terrain.
To date, most of the research into control of tensegrity robots has focused on slow motions which do not excite the dynamics of the structure. Wanting to show that tensegrity robots can be fast and dynamic movers, we are exploring what is possible when the structure is driven at the limits of dynamic stability.
To explore the maximum speed achievable by our tensegrity robot, Adrian’s intern, Atil Iscen, has been developing an evolutionary control approach where a large population of random tensegrity controllers are evaluated based on their ability to move the farthest distance within a fixed amount of time. Then, the worst performing members are eliminated from the population and the best ones are replicated and mutated, allowing the mutations of the good controllers to become even better.
Our best solutions so far evolve parameters to a distributed oscillatory controller where the lengths of groups of three cables (making a facet) are controlled by the values of a sine-wave. The job of evolution is then to control the phase offset, period, and amplitude of the sine wave for the strings. The breakthrough of this approach is that it enables fast dynamic motion, without requiring the computationally expensive modeling and analysis necessary for a centrally computed controller.
Our preliminary results show that tensegrity robots are indeed capable of fast dynamic motion, and that the evolutionary approach is successful at finding difficult to model dynamic controllers.
In the following video we show:
1) Slowly moving hand-crafted controller showing the difficulty of this problem.
2) An evolved controller showing high speed mobility
3) An evolved controller showing high speeds while handling rough terrain
While it is exciting to see such fast and dynamic motion from a tensegrity robot, rolling at the limits of stability is not the control approach we need for a space mission. When exploring another planet we need to balance the needs of making progress with concerns about energy efficiency and stability. Thus, we evolved a new controller with a tighter cap on the amount of stretch and energy available for each string. With that change we find results which appear stable and far more appropriate for exploration of a distant planet.
These results are preliminary and we expect to continue to improve the stability, energy efficiency, and terrain handling. Still, it is important to explore the upper limits of speed and dynamic performance. Further, we are establishing that evolutionary approaches are capable of parameter tuning and optimizing the performance of distributed control systems for dynamic tensegrity robots. This is important due to the deep challenges in hand crafting the dynamics of these complex and non-linear systems.
Moving forward we plan on exploring increasingly complex structures and distributed control architectures within which we will deploy our learning algorithms to tune performance. In other work we have already shown success at deploying distributed impedance control on tensegrity robots, along with compelling results from biologically inspired Central Pattern Generators (CPG’s). Both of these approaches require significant amounts of hand tuning of parameters, which our learning algorithms should be able to improve upon. Beyond the evolutionary approaches used so far, we also expect to explore multiagent control.


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The history of beer in the Yarra Valley is believed to go back to the early 1800s when growing hops was a major farming activity in the region. Whilst hops farms have disappeared today except for the odd hop kiln remains, the craft breweries in the Yarra Valley are working hard to make sure beer remains an important part of the Yarra Valley’s past, present and future. The Yarra Valley is also one of Victoria’s oldest cider regions and was the birthplace of Australian Champagne cider. It is believed that cider production dates back to the 19th century and records show cider production by Mac’s Lilydale cider from as early as 1934.
The Yarra Valley might be world famous for its wineries but it is also home to some of Australia's best breweries (and cideries). Combining great food, comfortable transport, VIP brewery access with knowledgeable guides dedicated to the history of the local region and beer and brewing guaranteeing guests will have the best experience possible.

domain: geography


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New Delhi: Homegrown app Koo has announced to hire some of sacked Twitter employees very soon. The co-founder Mayank Bidawatka, in a tweet offered to hire some of the Twitter ex-employees.“Very sad to see #RIPTwitterAand related # to this going down. We’ll hire some of these Twitter ex-employees as we keep expanding and raise our larger, next round,” Bidawatka tweeted.
“They deserve to work where their talent is valued. Micro-blogging is about people power. Not suppression,” he added. Elon Musk had given an ultimatum to remaining employees to be part of Twitter 2.0 where hard work and self devotion demanded or quit the company by Thursday night. The fresh exit after the massive layoff has left the company in shambles.
Koo has recently to become the second most used microblog app in the world. It has been downloaded in 50 million users in India. The company has announced to launch the app in the United States.


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The 2nd Congress of Cardiovascular Prevention in Pre-Elderly and Elderly Individuals (CPPEI) will focus on New Achievements in Research Diagnosis and Treatment.
The Congress has been designed to provide an innovative and comprehensive overview of the latest research developments in cardiovascular medicine, as well as responses to the most debatable issues primarily in the areas of the prevention of hypertension, diabetes, metabolic syndrome, coronary artery disease, heart failure, cardiac arrhythmias, stroke and acute coronary syndromes in Pre-Elderly and Elderly Individuals.
The Congress is aimed at experts and medical personnel in the field of Cardiology, Diabetes, Hypertension, Internal Medicine, Dyslipidemia, Endocrinology, Family Medicine, Nephrology, Nutrition, Geriatrics, Atherosclerosis, Cardiovascular, Cardiac Arrhythmia, Lipidology, Heart Failure, Stroke and Gerontology.
Don't miss the opportunity to join peers and key opinion leaders in Vienna, Austria, July 7-9, 2017. Get a head start, visit CPPEI 2017 website.

domain: health


text:
Tax Freedom Day
Assess how many days you'll work to pay your federal tax liability.
You are viewing this website at a small screen resolution which doesn't support calculators. Click here to view this calculator.
Separating the Signal From the Noise
A good professional provides important guidance and insight through the years.
Investment Strategies for Retirement
Investment tools and strategies that can enable you to pursue your retirement goals.
Medicare vs. Medicaid
The terms Medicare and Medicaid sound similar but are two very different things. Learn the differences in this informative article.

domain: economics


FAST SHIP Items normally ship from our warehouse the same business day when ordered by 3PM eastern time. Business days do not include weekends or holidays. Credit approval may require an additional 1-2 business days. Not responsible for carrier errors, weather or other acts of nature.
Single dipole antenna with an RP-TNC connector. The antenna provides indoor omni-directional coverage and is for use in the 2400-2500 MHz frequency band. It has a 90' articulation radius. It is for use with all radios that utilize an RP-TNC antenna connector.
Cisco Systems, Inc
Manufacturer Part Number
Manufacturer Website Address
Aironet Omnidirectional Antenna
Maximum Antenna Range
Frequency Band Type
2.40 GHz to 2.48 GHz
Number of Connectors
Wireless Data Network
All range estimations are based on an external antenna associating with an integrated Intel Centrino client adapter under ideal conditions. The distances referenced here are approximations and should be used for estimation purposes only.


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ST. JOSEPH, Ill. (WCIA) — A gym owner who opened despite the governor’s order is still fighting his case in court. The owner’s lawyer says there were flaws in the way the state’s attorney filed the restraining order.
The Zone Fitness Center gym opened last week despite a cease and desist order from the public health district. Champaign County State’s Attorney Julia Reitz filed a restraining order in response to that. The fitness center’s lawyer, Thomas DeVore, has now filed an appeal against the restraining order. He says Reitz should have filed an Action for Closure along with the restraining order for it to be valid. DeVore says a restraining order alone won’t get the job done. He adds that it’s simply not fair for the zone to have to remain closed.
“Why is it that every hotel in Champaign county has the right to have their fitness center open? Why is it when my client and I called a half a dozen of them that that their fitness centers were open 24 hours a day seven days a week and they don’t have staff in them? That’s irrational,” said DeVore.
Governor Pritzker has threatened fines or jail time for business owners who defy his executive orders. His administration issued an “emergency rules” warning to business owners, saying that, if they open their doors to the public before he lets them, they could run the risk of being charged with a Class A Misdemeanor. DeVore says that should never happen. “This is about treating people fairly and treating them equally,” said DeVore.
Champaign County State’s Attorney Julia Reitz won’t comment on anything pending. She has two days to come up with a response.


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The Georgetown swimming and diving team had an intense weekend, competing over three days at the Bucknell Invitational in Lewisburg, Pa. Both the men and women finished among the top-four teams in the meet, with the women breaking several program records in the process.
After 40 total events for both teams, the women finished in third place overall with 861 points, falling behind Bucknell University (1631 points) and Fordham University (1097.5 points). The men finished in fourth place overall with 709.5 total as Yale University took first place (1762 points), followed by Bucknell University (1147 points) and La Salle University (1124.5 points).
“We were prepared to swim fast and perform well as a team this weekend,” Head Coach James Holden said. “We weren’t necessarily worried about what other teams were doing, but more focused on what we could control.”
Following Friday’s seven events, the women’s team ranked third among eight teams while the men’s team was in fifth place among nine teams.
Freshmen Bailey Page and Kirstin Peterson and juniors Erin Timochenko and Erica Fabbri broke a Georgetown record for the women’s 200-yard freestyle quartet with a time of 1:34.94. The record-breaking time put the Hoyas in third place.
The men’s team finished fourth when it competed in the same event. Sophomore Will Leach, freshman Chandler Hinson, senior Michael Young and junior Michael Smigelski finished the race in 1:24.27 to place fourth in the men’s relay.
Sophomore Katie Duncalf, freshman Haley Owens, Fabbri and Page finished third in the women’s 400-yard medley relay with a time of 3:48.29, which also set a new Georgetown record.
In the men’s 50-yard freestyle, Leach finished fourth overall with a time of 21.03.
Sophomore Jared Cooper-Vespa wrapped up Friday’s events with a fourth-place finish in the diving competition, scoring 290.20 points.
The women held their third-place spot and the men moved up to fourth place after Saturday’s events.
Page led the women with the strongest individual performance of the meet. Page competed in the 200-yard freestyle with a time of 1:51.05 to earn the Hoyas’ first victory of the weekend.
“Bailey had a great weekend with all her races,” Holden said. “She had all best times in her individual events and the 200 free was a university record. She was an integral part of our strong relays as well. She loves to compete and is a great racer.”
Freshman Christine Ryan, who finished second in the women’s 500-yard freestyle on Friday, followed close behind Page with a third-place finish and a time of 1:51.59.
Fabbri finished fourth in the 100-yard butterfly with a time of 56.32 while Peterson finished eighth.
For the men, sophomore Martin Vanin finished third in the men’s 100-yard butterfly with a time of 49.69 and sophomore David Chung finished seventh.
The women had 553.5 points going into Sunday, giving the team the momentum it needed to finish strong on the final day of competition. Duncalf led the team by breaking another program record with her time of 2:03.57 in the preliminary round of the women’s 200-yard backstroke. Duncalf qualified for Group A finals, where she finished in eighth place.
Page, Fabbri and Peterson, who competed in the freestyle race for the women, placed second, fourth and seventh, respectively, in the 100-yard freestyle Group A finals,
The 400-yard freestyle relay quartet continued its success from Friday and finished second overall with a time of 3:25.49.
Freshman Molly Fitzpatrick finished third in the 200-yard breaststroke finals with a time 2:20.23, after breaking a program record during the morning preliminary round with a 2:19.65.
The relay team of Chung, Leach, Smigelski and Hinson led the men with its fifth place finish in the 400-yard freestyle. They completed their race in a time of 3:07.20.
The Hoyas were pleased with the results of their races, but they were also happy to have the opportunity to race in an environment that will be similar to one of their most important meets of the season.
“This was good experience for our team in getting prepared for Big East championships as the competition was a very similar format as our championships will be in February,” Holden said. “I knew if we swam to our potential, which I felt we did, that the points and team scoring would take care of itself.”
The Hoyas will return to the pool Dec. 6 when they face off against Howard University at 1 p.m. at McCarthy Pool.
“I think we will be focusing on some versatility next weekend with our line up against Howard,” Holden said. “We need to get back to focusing on training for the second half of the season at this point.”

domain: sports


On Tuesday, we discussed the ACC’s most significant departures in men’s basketball (yes, that includes Mr. Allen). Here’s what else went on around the Virginia Cavaliers world yesterday:
UVA Men’s Basketball’s top 21 players in the Tony Bennett era (Wahoos247)
UVA’s 247 Sports page finished up their rankings of the best players to ever play under Head Coach Tony Bennett. Click the link above to see who made the final tier.
Tony Bennett on playing for his father in college (syracuse.com)
In a recent article that touched on the topic of dads coaching their sons at the college level, current Virginia Head Coach and former division one basketball player Tony Bennett chimed in on the conversation. Bennett, who played for his father Dick Bennett at Wisconsin-Green Bay in the late ‘80s and early ‘90s, joked, “I’m still in counseling after playing for my dad [...] I’m kidding. Kind of.”
Hunter listed second in ranking on potential NCAAB breakout candidates (CBS Sports)
Kyle Boone of CBS Sports tabbed UVA redshirt sophomore De’Andre Hunter his second most likely player to break out in the 2018-19 season. Hunter, who averaged 9.2 points per game last season, expects to play a big part in the team’s ACC title defense.
UVA to scrimmage Richmond, Villanova in late October (Watch Stadium)
The private exhibition games that occur in the coming weeks allow teams to see where they stand prior to the start of the college basketball season. On Virginia’s schedule is a matchup at Richmond on October 20th and a game at home versus Villanova - which Watch Stadium ranked as the top scrimmage - a week later on the 27th.
Congrats to Chris Taylor and the @dodgers on making it back to the NLCS! #ProHoos https://t.co/QvrYpIyHr0— Virginia Baseball (@UVABaseball) October 9, 2018


text: Teeki is an eco-conscious activewear line. We dance to a different beat, stretch with the yogi, run to the highest peaks, hike in unexplored territories, and swim where the oceans becomes one. All our clothing is made from fabric that is spun from fibers made out of recycled plastic water bottles, then cut, printed, and hand sewn with love using only environmentally friendly practices. Unlike other prints, these one-of-a-kind graphic prints are part of a storybook, taking you on dreamy adventures to new and exotic places. Teeki is conscious, Teeki is love, Teeki is made for you.

domain: design


text:
BioGEM - ST
Growth Enhancing Mycorrhiza
CENTOR EUROPE's Growth Enhancing Mycorrhiza. A seed treatment formulation containing a unique selected blend of Mycorrhiza, allowing for rapid colonization of the root zone of a plant. The Mycorrhiza improves the soil condition, enhances root hair formation, whereby improving the uptake of plant nutrients and improved tolerance to a variety of abiotic stresses.
BioGEM-ST is supplied as a highly concentrated water-soluble powder (20800 propagules / g) and is added to the seed coating binder before application to seed. Application at 1g/kg for Horticultural crops. BioGEM-ST contains living micro-organisms and the product cannot be used in combination with any disinfectant chemicals or plant protectant products. BioGEM-ST is compatible with BioCARE-ST and HortiBAC-ST/AgriBAC-ST for broader biological activity in the rhizosphere and soil microbiome.
BioGEM is compatible with the following Centor Europe Seedworx coatings;
- BioFriendly 1
- Flare 3
- Stix 1 (binder for pelleting)Request info

domain: agronomy


Overview: The Model RO1 is a top quality multipurpose hose for use with convenient push-on fittings up to 3/4" diameters. No special crimping tools are required, which allows the fittings to be inserted easily. It has an oil and heat resistant nitrile tube and neoprene oil resistant cover, and is reinforced with braided fabric laid at the optimal angle for coupling holding capability. All sizes rated for 300psi.
- Push-on Fittings Allow for Cutting to Length in the Field with no Crimping Tools
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- Good Flexibility
- Wherever a Quality Multipurpose Hose is Needed with Cut-to-Fit Versitility.
- Industrial Air & Water Applications
Temperature: -40 to 190F
|Outer Dia |
|Bend R |
|3/4||1 1/16||300||6 1/4||0.37|


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This cake was inspired by my recent trip to Ireland. So many beautiful flowers, I hope to get the opportunity to make many of them. I don’t even know the name of the conical flowers represented in sugar , but they were everywhere in the countryside.
3,4 and 6 inch cake finished in buttercream with hand painting and orange sugar flowers
Lori-Ann,The Cake Studio Cayman,http://www.facebook.com/pages/The-Cake-Studio-Cayman/136313133106508?ref=tn_tnmn


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Legislation has been signed removing mandatory license suspension for most drug offenses in Massachusetts. The law:
- Eliminates license suspension for most drug offenses;
- Removes the mandatory license reinstatement fee;
- Maintains a license suspension period for those convicted of trafficking in certain substances.
As a result, if you are charged with a drug offense, it is important to know that your license may no longer become a collateral consequence. Reach out to a drug attorney today who can help you. Contact Attorney Shane W. Surrette at (774) 364-4605 or at [email protected]


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Targeted treatment with the fibroblast growth factor receptor (FGFR) inhibitor erdafitinib improved responses and overall survival compared to standard chemotherapy for patients with metastatic urothelial cancers with FGFR alterations. Results from the Phase III THOR trial, led by researchers at The University of Texas MD Anderson Cancer Center, were reported at the 2023 European Society of Medical Oncology (ESMO) Congress.
“Metastatic urothelial cancer continues to challenge us with its absence of a cure, highlighting the need for innovative treatment approaches,” said Arlene Siefker-Radtke, M.D., professor of Genitourinary Medical Oncology and senior investigator on the trial. “This ongoing study presents compelling evidence that erdafitinib could potentially serve as a valuable targeted treatment option for individuals with FGFR alterations.”
Genetic changes in FGFR are present in approximately 20% of patients with metastatic bladder cancer and up to 35% of patients with other urothelial cancers, including renal pelvis and ureter cancers. In 2019, erdafitinib was approved by the Food and Drug Administration for advanced FGFR-altered urothelial cancer based on the results of a Phase II trial led by Siefker-Radtke. It was the first approved FGFR-targeted therapy and is the only approved FGFR-targeted option for advanced urothelial cancer.
The ongoing randomized THOR trial, conducted at 121 sites in 23 countries, evaluated the efficacy and safety of erdafitinib in patients with metastatic urothelial carcinoma and selected FGFR gene alterations. Patients were screened for the presence of FGFR gene alterations and assigned to two cohorts based on prior treatment with platinum-containing chemotherapy or immune checkpoint inhibitors.
Erdafitinib significantly improved overall survival relative to chemotherapy in patients with prior immunotherapy
In the study’s first cohort, published in the New England Journal of Medicine, 266 patients who had prior treatment with immune checkpoint inhibitors were randomized to receive either erdafitinib or chemotherapy.
The median overall survival (OS) was 12.1 months and 7.8 months, respectively, corresponding to a 36% lower risk of death for those treated with erdafitinib. The OS benefit was seen across subgroups, including age, type of FGFR alteration, number of prior lines of treatment, visceral metastasis, location of the primary tumor and type of chemotherapy.
Further, erdafitinib achieved a median progression-free survival of six months compared to just three months for chemotherapy. Nearly half (46%) of patients treated with erdafitinib had an objective response, meaning their tumors shrank, while just 12% on the chemotherapy arm had an objective response. The data from this cohort was first presented at the 2023 American Society of Clinical Oncology (ASCO) Annual Meeting.
Erdafitinib achieves similar outcomes compared to pembrolizumab in immunotherapy-naïve patients
In the second cohort, published in the Annals of Oncology, 351 patients who had not received prior immunotherapy were randomized to receive either erdafitinib or pembrolizumab (anti-PD-1). There was no statistically significant difference in OS between the treatment arms, as erdafitinib had similar survival compared to immunotherapy in patients who received prior pembrolizumab.
Erdafitinib did achieve a median progression-free survival of 4.4 months compared to 2.7 months for pembrolizumab. Further, 40% of patients treated with erdafitinib had an objective response, while just 21.6% on the pembrolizumab arm had an objective response. There was a shorter duration of response with erdafitinib (4.3 months) than with pembrolizumab (24.4 months).
“The data from this new cohort provides early evidence suggesting there may be important impacts from the sequence of treatments for an FGFR3-altered urothelial cancer,” Siefker-Radtke said. “Even though most primary FGFR-altered urothelial tumors are immunologically cold, it is possible that metastatic tumors may not share the same features. Perhaps these patients could benefit from combining erdafitinib with an immune checkpoint inhibitor.”
Treatment-related adverse events across both cohorts were manageable and consistent with the known safety profile of erdafitinib. The impact of erdafitinib on the OS of patients with metastatic urothelial carcinoma and FGFR alterations highlights the importance of conducting molecular tests to identify FGFR alterations in individuals with metastatic urothelial cancer.
Further work is necessary to understand the impact of combining and sequencing erdafitinib with a checkpoint inhibitor. There may be a role for erdafitinib in patients with visceral crisis where rapid response and symptom improvement is indicated, thanks to its higher response rate.
Yohann Loriot et al, Erdafitinib or Chemotherapy in Advanced or Metastatic Urothelial Carcinoma, New England Journal of Medicine (2023). DOI: 10.1056/NEJMoa2308849
A.O. Siefker-Radtke et al, Erdafitinib versus pembrolizumab in pretreated patients with advanced or metastatic urothelial cancer with select FGFR alterations: cohort 2 of the randomized phase III THOR trial, Annals of Oncology (2023). DOI: 10.1016/j.annonc.2023.10.003
New England Journal of Medicine
Annals of Oncology
Source: Read Full Article


This Federal 40 S&W HST is loaded with one of the most revered self-defense bullets out there - 165 grain HST Jacketed hollow point projectiles. It’s a great middle ground between the faster rounds and the harder hitting ones. Penetration is solid and consistency in expansion is excellent. The uniformity of the HST projectile means it will be a proven winner when you need it most.
Not only is this round consistent when expanding on impact in the target, but the consistency of manufacture and the consistency of the component parts is significantly better than most rounds you might be shooting at the range at this price point. Make no mistake, it isn’t “cheap” per se, but it offers an excellent value for those who know they want to practice with what they intend to carry. The price point being what it is from BulkAmmo.com, this is an obvious opportunity for many, and will give you a legitimate opportunity to get to know your firearm and be able to anticipate the parts you can anticipate in a personal defense scenario.
This is for a full bulk case of the Federal’s HST in 40 cal. You’re going to get 20 boxes, with each containing 50 rounds ready to protect you and your family. Plus, since you’re buying in bulk you can sleep easy knowing you’re getting a cheap price!
Review by Voyager
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