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While recent medical and surgical advancements have improved outcomes for some cancers, ovarian cancer remains the leading cause of gynecologic cancer death among women in the United States. Investigators at Providence Cancer Institute hope a new phase II clinical trial of neoadjuvant chemotherapy (NACT) plus immunotherapy will improve survival for patients with advanced epithelial ovarian, fallopian tube, or primary peritoneal cancers.
Providence is the only center in Oregon to offer the trial. Find the details here:
A Phase II Study Evaluating Intraperitoneal GEN-1 (IL-12 Plasmid Formulated With PEG-PEI-Cholesterol Lipopolymer) Administered in Combination with Neoadjuvant Chemotherapy in Patients Newly Diagnosed with Advanced Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer (OVATION 2)
In this randomized, open-label study known as OVATION 2, investigators will evaluate the safety and effectiveness of GEN-1, an experimental DNA-mediated interleukin-12 (IL-12) immunotherapy, given with standard-of-care NACT (paclitaxel and carboplatin) compared to NACT and surgery alone.
IL-12 is a cytokine involved in the anticancer immune response of T-lymphocytes and natural killer cells. GEN-1 utilizes a nanoparticle delivery system designed for local administration of the IL-12 plasma vector to avoid the toxicities associated with recombinant IL-12.
The U.S. Food and Drug Administration granted GEN-1 Fast Track designation in February following promising preliminary data and a manageable safety profile.1 In the dose-escalation portion of the study, all patients in the high-dose experimental cohorts achieved a complete or partial response, while 67 percent of patients in the low-dose experimental cohorts reported a complete or partial response.
Patients with newly diagnosed stage III/IV cancers are eligible, including:
- high-grade serous adenocarcinoma
- endometrioid adenocarcinoma
- undifferentiated carcinoma
- clear cell adenocarcinoma
- mixed epithelial carcinoma
- adenocarcinoma not otherwise specified (N.O.S.)
The study is led by Christopher Darus, M.D., MS, gynecologic oncologist and medical director of the Providence Gynecologic Oncology Program. Dr. Darus is an experienced investigator and active member of the Society of Gynecologic Oncology and other leading medical associations dedicated to advancing research, treatment, and prevention of gynecologic cancers.
For more information or to enroll a patient, call our Clinical Research office at 503-215-2614 or submit a referral form.
See more gynecologic cancer studies
Our research portfolio includes more than 15 clinical trials for gynecologic cancers. From early-stage disease to metastatic cancer, our studies include phase I, first-in-human studies and NCI-supported cooperative group trials of surgical procedures, immunotherapies and other investigational agents in the adjuvant and neoadjuvant settings.
New studies are added frequently. Please visit our website to view studies for all types of cancer.
A team of gynecologic cancer specialists
The Providence Gynecologic Oncology Program provides specialized care for women with suspected or known gynecologic malignancies and complex precancerous conditions. Through the program, patients have access to advanced treatments, such as robotic surgery, immunotherapy, and the latest research and clinical trials. Patients also have the convenience of receiving all their care under one roof.
In addition to our providers, members of the team include oncology nurses, radiation oncologists, gynecologic pathologists, genetic risk experts, oncology social workers, integrative medicine providers, nutrition specialists, clinical trials nurses, medical assistants, and others.
To learn more, visit Providence Gynecologic Cancer Program.
Rosa, K. FDA Grants Fast Track Status to Immunotherapy GEN-1 in Advanced Ovarian Cancer. OncLive. 2021 Feb 22. Accessed May 14, 2021. https://www.onclive.com/view/fda-grants-fast-track-status-to-immunotherapy-gen-1-in-advanced-ovarian-cancer


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On 2 November 2017, Otilia Perichart-Perera joined the Maternal Health Task Force (MHTF) for a panel discussion about noncommunicable diseases and maternal health. Later, she sat down with the MHTF’s Sarah Hodin to talk more about the issues she raised during the dialogue.
SH: Please start by telling me a bit about you and your work.
OPP: My background is in nutrition, health promotion and food sciences. I’ve been working as a researcher at the Instituto Nacional de Perinatología in Mexico City, focusing on nutrition in high risk pregnancies. I’ve conducted studies evaluating nutrition interventions to prevent and treat pre-eclampsia, gestational diabetes and obesity in pregnancy. Currently I’m interested in maternal nutritional status and how that affects the fetus. Both undernutrition and overnutrition during pregnancy are not only dangerous for women but can also have a long-lasting impact on their children.
SH: Your paper, “Metabolic markers during pregnancy and their association with maternal and newborn weight status,” that was published in the new MHTF-PLOS Collection examined obesity in pregnancy in Mexico. What was the impetus for the study?
OPP: Three-quarters of women of reproductive age in Mexico are considered to be overweight or obese. This is a major problem because obesity in pregnancy is associated with many poor maternal and newborn health outcomes including gestational diabetes, pre-eclampsia, intrauterine growth restriction, miscarriage and hemorrhage.
SH: What did you find?
OPP: The markers we studied were all related to nutrient transport and metabolism, including energy substrates, hormones that affect metabolism of nutrients and proteins that participate in cell signaling. We found that women who began pregnancy with excessive weight had higher concentrations of many of these markers, even if they did not develop gestational diabetes. This may indicate an increased risk of nutrient-related complications in the fetus. We also found that excessive maternal weight gain at the end of pregnancy was associated with insulin resistance, an indicator of altered glucose metabolism. Our findings exemplify that screening for gestational diabetes is not enough. We need to offer more comprehensive prenatal care that incorporates other tests.
SH: We spoke earlier about how the maternal health and NCD communities tend to work in silos. Do you think the same applies to the fields of nutrition and maternal health?
OPP: I don’t think that nutrition is generally included in maternal health services in Mexico. Often nutrition is not positioned as a priority during prenatal care, for instance. Part of the problem is the limited number of health professionals who are nutrition-oriented. Nutrition is not a focus in Mexico’s health system—it’s not emphasized in medical education and training programs. Also, prenatal visits tend to be short and clinically-oriented, so there’s not enough time to discuss healthy pregnancy behaviors including nutrition.
SH: What would you like to see happen to better integrate nutrition into maternal health services?
OPP: We need quick, easy educational messages based on behavioral change as opposed to highly prescriptive dietary guidelines. We also need to move away from the curative, diagnostic perspective on health towards a model of clinical care centered on early prevention. Nutrition interventions should aim to empower women to make lifestyle changes for themselves and their babies.
Browse resources related to nutrition and maternal health.
Watch the video of the panel discussion about NCDs and maternal health featuring Otilia Perichart-Perera.
Explore other open access papers from the MHTF-PLOS Collection on NCDs and maternal health.

domain: medical


Indigo is an ancient dye derived from the leaves of plants and surrounded by magic, mystery, and folklore. Discover how the leaves ‘make blue’ by learning about the character and chemistry of the natural indigo vat.
The complex chemistry of the indigo vat is fascinating and students will soon appreciate how rituals have grown around the making and using of a successful vat. The unique ‘attaching’ of indigo to fiber means it is particularly suited to resist methods of dying, such as shibori, where portions of cloth are closed off to the dye or where the flow of dye is restricted. Different shades of blue build on the fabric after several dips, exhibiting the beautiful graded hues which are so typical of indigo.
SKILLS/TECHNIQUES COVERED: Students will initially learn how an indigo vat is made. A vat will be prepared in the morning and the basic chemistry explained. The natural indigo powder will be used, and the vat will be ‘reduced’ using a commercially available chemical. While the vat develops, students will be shown several shibori techniques: a folded and clamped method, and a twisted and tied technique. Students can expect to make several napkin-sized samples, a scarf or a t-shirt
LEVEL: Beginner and intermediate
Stuart, FL 34994


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Craig's Wonder BoxExclusively from Illusion Arts Magic
A new method for this classic effect that allows the box to be complete examined before and after the trick is performed. An attractive oak box is displayed and shown to be empty. It can be examined. Then the magician waves his hand and magically a beautiful multi-color streamer or silk of your choice is produced. A limited number of these will be made.
Price: $200.00 USD
Click here to purchase

domain: hobby


Checked it. Not loose
Just based on the conversation so far, I am leaning toward this being an ammo issue. Grab a box of good American ammo and see if it helps.
If not, then you should get her to a gunsmith. Good luck sir.
Ummm… maybe you could return it to the store you bought it from?
$40,000 he’s actually says "a couple 100,000’ so even doubly impressive
Hopefully. I have the receipt.
Did you buy in store or online?
Wait a minute. Are we talking about returning the imported (probably out of spec especially since different ammunition at a friends place fed and ejected fine) ammunition or the used rifle that was fired 150 times? The gun shop I frequent says once the firearm is sold and they do the paperwork it’s a used firearm. Even if you don’t take it out of the store.
Did you ever get some different ammunition to test the rifle?
My other .223 works in it, the Frontier .556 my coworkers husband had, fit in nicely and released, certain rounds from the box I had fits, others locks it up. I’m talking about returning the ammo back to the range I got it from. I’m keeping the rifle. I double checked everything everyone told me to check, and there’s really nothing that seems out of place with the rifle.
Back to the tolerances I was talking about earlier. If you got a rifle on the tighter side of things then you might have gotten lucky and received a production rifle with excellent accuracy!
We are all looking forward to seeing your results!!
All sales are final. That is a bummer. Maybe you could send an email to the manufacturer and see if they will help you out?
You could invest 20 bucks in the ammunition checker and sort out the faulty cartridges.
I would just shoot them.
Would you have any concerns about firing out of battery?
Hit the forward assist after chambering each round?
Yeah I’d rather test the ammunition with a gauge, and just throw them away. I don’t want to shoot faulty ammunition.
Been back to the range? How’s your rifle running?
I haven’t gone to the range yet currently saving money for the USCCA expo. I just loaded it with .223 rounds and the .223 that I have doesn’t lock the bolt up.


By ET Bureau - November 15, 2023 1 Mins Read
Kasm Technologies has partnered with GST to provide web desktops, application streaming, and web isolation tech for secure client computing. The company will integrate its containerized workspace solutions with GST’s comprehensive digital transformation and client computing services.
It will provide customers with scalable, cost-effective, and security-driven enterprise browsing and cloud workspaces.
Jaymes Davis, Chief Product Officer of Kasm Technologies, says GST’s dedication to robust client computing services aligns perfectly with their vision of delivering high-performance, user-friendly, browser-based workspaces boosting enterprise browsing possibilities.
The platform covers e entire enterprise technology space- including emerging technologies like RPA, AI, cloud, automation, and the entire gamut of digital transformation tools, strategies and management decisions.
A Peer Knowledge Resource – By the CXO, For the CXO.
Expert inputs on challenges, triumphs and innovative solutions from corporate Movers and Shakers in global Leadership space to add value to business decision making.Media@EnterpriseTalk.com


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Is a process you go through that moves you up a ladder of awareness or perception to the level of a glimpse into the unconditioned Absolute, the perfect spiritual idea or pattern. The moment you have a taste of it, of that pure wholeness, you are experiencing a breakthrough into a higher and greater awareness. It is a flash of pure “knowing.” This knowing, this breakthrough in awareness, becomes a directive to the creative law, the truth that does the healing. At this point the problem goes; it automatically or spontaneously dissolves in this new awareness. You see a change in your experience, in your life. There are four stages, or components, of every spiritual treatment: recognition, unification or identification, particularization, and release. All treatments include these four components.
You recognize that Infinite Intelligence and Power is everywhere, always. It is within all beings, all life. You are not simply a materialistically, physically-ordered individual. You live in life, you experience life, you embrace life humanly and physically, you love it, but you are in essence oriented toward primary cause, the prototype behind your experience of life. You are part of the universal Mind and you express an archetype or pattern in it.
The second part of a treatment is unification or identification, in which you identify yourself as an individualized part of the whole. We are like the rays of the sun or like flowers on a plant; each of us is individual but still connected to, still part of, the whole. In treatment this is expressed with words like “This creative intelligence is acting through me, expressing as me. It is my mind now, operating through me.” Another way to think of yourself is as a wave on an infinite ocean. Thus, in reality you are the ocean as a wave. All the elements or chemicals of the ocean must also be in its wave. We say the human consciousness is the bridge between the universal mind and the particular expression in an individual form.
In the third step of treatment, particularization, you state that every wrong belief, every blockage, every suggestion that you are separate from the whole, is hereby banished, neutralized, dissolved, as a result of your purposeful thinking. Therefore you are able to see clearly who you are, what you are, where you are, and know what to do. You recognize that the perfect pattern or prototype for your experience (specific health of a body part or function) exists and is the substance and form of your body experience now.
The final stage of treatment is release. You surrender to the action of the universal intelligence or Mind and release the healing treatment to the law of creative action, knowing change or fulfillment is happening. It cannot fail to happen, because it is the neutral action of the universal law. Benefitting from Spiritual Healing
Spiritual healing does not promise that anything and everything can be changed at any time. Not everyone will experience a healing. The premise of spiritual healing is valid, but its to human experience is different. It appears to work more immediately and completely for some people than for others. This is due largely to the person's state of mind and receptivity to ideas. Nonetheless, everyone benefits in at least some the techniques of spiritual healing. At the very least, you will gain a broader, larger view of life and of yourself, and you will live with much greater hope and with positive, constructive thinking that comes from spiritual understanding. You will receive an empowerment in your state of mind and thus in your affairs. Some people experience very dramatic effects.

domain: literature


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Monday was the first day of the famous San Fermín festival in Pamplona, Spain. It is more commonly known as the running of the bulls.
This tradition dates back to 1591, when men would rush their cattle to be the first to the marketplace. Each morning this week, people will gather to run with the bulls as they race down the street, from pen to bullring, where there will be bullfights the rest of the day.
Though the festival is beloved by many — and glorified in Hemingway's The Sun Also Rises — some people are hoping that the sun will set on this tradition. On Saturday, animal activists lay on the ground outside the entrance to the Pamplona bullring, painted red and sporting bull horns. The activists, mainly from the animal welfare organizations People for the Ethical Treatment of Animals and AnimaNaturalis, held signs saying: “Pamplona’s streets are stained with bulls' blood." They are calling for an end to the bullfighting tradition in Spain, saying it abuses and harms the bulls.

domain: news


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Deji Adeyanju, a human rights activist and social commentator, has been admitted into the Nigerian Bar.
In a statement personally signed by him on Wednesday, Adeyanju said he would use the knowledge and instrument of the law to advocate for the oppressed and all those who are unable to speak out or defend themselves.
The lawyer said he would commit his time, resources and knowledge of the law to the fight against corruption.
He said: “Recognising the important role of the judiciary in the life of our nation, I will advocate for an increment in the salaries of all judicial officers across board.
“It is indeed shameful that while governors, lawmakers and even their aides earn humongous amounts under a four year term, members of the judiciary who have dedicated their entire life to doing justice to all manner of persons earn peanuts.
“A judiciary where a Supreme Court Justice earns barely N3,000,000 (Three Million Naira) per month is a judiciary vulnerable to corruption. I will use the instrumentality of the law to advocate that no Supreme Court justice should earn less than N15,000,000 (Fifteen Million Naira) per month.
“I will commit my time, resources and knowledge of the law to the fight against corruption. In almost all areas of our national life, corruption has become pervasive and there is no better time than now for us to confront this monster.
“I will, as often as possible urge the relevant security agencies to investigate allegations of corruptions and where they fail to do so, I will seek orders of mandamus compelling them to do their jobs, as well as fiats from Attorney General of the Federation to prosecute corruption cases.
“I will continuously seek the interpretation of knotty constitutional issues that affects the life of our nation and the wellbeing of its citizens. My fidelity to the Constitution and the Nigerian people will remain my guiding light in all I do. I commit to use my license and knowledge of the law for the benefit of all Nigerians.”

domain: sociology


Title: Orientation and perspectives of the German Federal Government's research and technology policy
Authors: Heinz Riesenhuber
Addresses: Minister for Research and Technology, 5300 Bonn 2, Postfach 20 07 06, West Germany
Abstract: The Minister for Research and Technology of the Federal Republic of Germany describes his Government|s philosophy and policies on research, technology, innovation, environmental conservation, and on aid for development in the Third World.
Keywords: Federal Republic of Germany; government policy; research policy; technology policy; innovation; environmental conservation; development aid; developing countries; R&D; research and development.
International Journal of Technology Management, 1986 Vol.1 No.3/4, pp.266 - 270
Published online: 27 May 2009 *Full-text access for editors Access for subscribers Purchase this article Comment on this article


December 18, 2014 in Commentary
Within the first few months of public White Advocacy, I started receiving death threats on my phone number, 317-324-8282 and at my email@example.com email address. I was repeatedly threatened with being “doxxed”, so I was careful to conceal my [redacted, at girlfriend's request] social security number. My employers were repeatedly pestered by the SPLC and others, which led to my current arrangement of being a long-haul trucker who performs freelance computer consulting work in my mobile office. It’s rudimentary to take my CDL to a different outfit if this one cans me, and most of my freelance clients couldn’t care less if I were an ax murderer, as long as I deliver solid code.
I would offer my home address, but I live in my truck, so I don’t really have one to offer.
The heckler’s veto which the Internet’s anonymity provides has resulted in a profound chilling effect on public discourse, and has steadily grown from a childish prank phone call stunt targeting toxic extremists like yours truly to this obnoxiously familiar canard peppering every major public political brawl. With the recent #gamergate hassle, each side eagerly served up death threats and eagerly presented the death threats as a farcical sort of digital badge of courage that they were supposedly risking their lives for feminism or social justice or whatever. Read the rest of this entry →


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Willow Charter taking shape
Plans are taking shape for Willow Charter Academy that will open in August for kindergarten through fifth grade students.
There will be 492 slots available for students at the new charter school, which is managed by National Heritage Academies. NHA Admissions Manager Susan Machiela said the school has already received more than 100 applications since enrollment opened in January.
To keep most class sizes to 28 students or less, the school will have no more than four sections of kindergarten, three sections each of first through fourth grades, and two sections of fifth grade.
An informational meeting was held Tuesday afternoon for parents who are interested in applying.
Machiela confirmed that the school will be in the vicinity of the Northgate Mall, in an existing building that will undergo extensive renovations. Because paperwork is still being processed, Machiela said she could not immediately share details about the site.
“We don’t 100 percent own it yet. We’re 99 percent of the way there,” she said.
Meanwhile, an open enrollment period will run until March 3. If the school receives more applications than there are slots, a lottery will be conducted. Those who do not receive a spot through the lottery would be placed on a waiting list.
Tamika Draper, NHA director of school quality, said because the school is authorized by the Louisiana Board of Elementary and Secondary Education, it will follow state-mandated standards, including Common Core and Grade Level Expectations. Willow Charter will also have its own set of academic guidelines.
Draper each student will be tested in August to assess his or her academic level. Other assessments will take place in January and May to see how well students are progressing. The tests are in addition to regular class tests, report cards and progress reports.
Draper said NHA schools have an average 133 percent academic growth rate, meaning that students grow their skills by about a year and three months over the course of a school year. Willow Charter teachers will be expected to try to meet or exceed that standard. The company has a pay-for-performance model for its teachers, with a heavy focus on how much students are developing in their academic skill set. Teachers are formally observed each week, and then have one-on-one meetings with administrators to discuss their performance.
“If we’re not meeting those goals, we have to do something different,” Draper said. “We expect students to grow by at least a year, if not more.”
Draper added that the school will have a principal and at least three deans, with each dean overseeing certain grade levels. Some NHA schools have other deans for more specialized areas, and that is a possibility at Willow Charter if the need arises.
Machiela said the school expects to hire a principal shortly, and that the hiring of other administrators, teachers and support staff would likely begin in late spring.
Willow Charter will be one of the first charter schools of its kind in Lafayette Parish. Georgia Norbert, whose daughter attends Holy Rosary, said her child will be in kindergarten next year, and she likes the idea of placing her in a new school.
“I like that it would have before-school care and after-care,” Norbert said. “It’s something new. She could grow with the school through the years as it grows.”
Andria Navarre, whose two daughters currently attend Breaux Bridge Primary School, said she is looking into various alternatives to public education. She said she liked that Willow Charter will follow the same state academic standards, such as Common Core, but that the environment would probably be different.
Machiela said one of the key areas for NHA schools is a moral focus. Schools pay special attention to areas such as wisdom, respect, gratitude, self-control, perseverance, courage, encouragement and compassion. There are regular assemblies focusing on those topics, which are also incorporated into daily learning.
Navarre said that is something she would like to see in her children’s schools.
“They used to have that in public schools, and we’ve kind of gotten away from it. I’d like my children to have it,” she said.


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Bingo games on mobile Australia for you
The virtual game Bingo is extremely popular in Australia. It is played by users of all ages. Especially this fun lottery-type game is common among the female half of the population.
Bingo games on mobile Australia is also called the word «housie». Today, many gambling sites offer users this amazing and simple game. In order to start competing in it, the player only needs to choose a suitable online casino site or simply download the mobile version of Bingo on his smartphone.
Varieties of free Bingo slots
There are thousands of people who like to play Bingo today. Especially many fans of this game live in Australia.
As you know, the most popular types of online Bingo in 2020 are:
- Bingo games on mobile Australia such as 30 ball Bingo;
- 75 ball Bingo;
- 80 ball Bingo;
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Each free mobile Bingo no deposit offers users great advantages and excellent chances to win real money. In the game of Bingo, you can not only win real money rewards, but also earn bonus points that will help you raise your gambling rating in the future.
Every virtual site with Bingo games in Australia, which by the way can be downloaded to the user’s mobile device, has a clear and understandable schedule of gambling rounds. You can launch no deposit mobile Bingo even without required pre-downloading to your tablet or phone. The mobile version can be enabled in browser mode.
Users of Australian online casinos do not like to limit themselves in gambling fun, and therefore they use versions of Bingo games on mobile Australia to play at any needed time and in any convenient place.
Professional online Bingo players recommend that beginners buy multiple cards for a single round, as well as participate in several games per session. Of course, the more cards you buy the more odds you have to win big. At least, those gamers who have already experienced it many times are sure of this.
Many modern Bingo games on mobile Australia also give their customers the opportunity to get large jackpots. Progressive jackpots are made up of total prize funds and amount to hundreds of thousands of US dollars! If luck is on your side, you may be able to break a large bank.
How to win mobile Bingo fraudulently?
In our world, there are people who prefer to live fair life, and there are those who are willing to cheat for their own benefit. The same goes for gambling. Many dishonest people try to cheat gambling establishments or websites in order to get cash prizes fraudulently. This is not fair and is even punishable by law.
Of course, at all times, some people have tried to get rich by cheating. Today, when our world has the Internet, there are such scammers who come up with various schemes that help to deceive online casinos and hack the Bingo game. Fortunately, there is also a well-established security system for virtual clubs that closely monitor possible attacks by hackers and other scammers. All new security schemes are appearing in the world of the Internet, so it is not so easy to cheat online casinos in 2020.
If you are offered various illegal schemes to keep winnings and hack the Bingo games on mobile Australia, do not agree to allow such actions. If you take part in this, it will mean that you are involved in criminal activities. Remember that gambling is primarily an entertainment. For a decent person, having fun in an illegal way is unacceptable, a priori. Bad actions will have negative consequences, even if you initially think that your crime will get away with it.


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There are three major types of skin cancer: basal cell carcinoma, squamous cell carcinoma, and melanoma. Melanomas are the most lethal of the three, accounting for 90% of skin cancer deaths. When found early, the 5-year survival rate for localized melanoma is 99%. However, this number significantly decreases to 63% and 20% for melanoma with regional and distant metastasis, respectively. A big contributor to this poor prognosis is the lack of effective, durable treatments for unresectable, metastatic melanoma.1,2
Melanomas exhibit a high rate of somatic mutations when compared to other types of cancer. The majority of these mutations are passenger, or silent, mutations that are not vital for melanoma development. However, numerous mutations have been identified as oncogenic, or driver, mutations, that result in constitutive activation of signaling pathways that promote tumor growth and survival.3
Melanoma-Promoting Oncogenic Mutations in the MAPK and PI3K/Akt Pathways
B-Raf is the most frequently mutated oncogene in melanoma. B-RafV600E mutation is the most prevalent mutation, found in over 50% of melanomas, that confers sustained proliferative signaling on the skin cells. N-Ras is the second most prevalent mutation and is observed in 30% of all melanomas. These activating mutations lead to subsequent activation of the downstream MEK, which in turn activates MAPK. Mutations in other oncogenes like c-Kit and Gαq also lead to activation of proteins in the MAPK pathway like Ras, Raf, MEK, and MAPK. Collectively, aberrant activation of the MAPK pathway is found in over 90% of melanoma, an ideal scenario for targeted therapies.1,4 Several inhibitors targeting B-Raf and MEK have been approved by FDA to treat melanoma.
The PI3K/Akt pathway, which regulates cell proliferation and survival, is also implicated in melanoma. Interestingly, Ras sits at the intersection between the MAPK and PI3K pathways. Thus, Ras protein mutations can activate both pathways. High levels of phosphorylated Akt have been observed in two-thirds of primary and metastatic melanomas. This may partially be due to loss of function mutations in PTEN observed in 10-30% of melanomas. mTOR mutations are also present in 10% of melanomas and correlate with poorer survival statistics.1,3
Additional Potential Therapeutic Targets for Melanoma
Other pathways with potential therapeutic targets include the Wnt and NF-kB pathways. However, targeted therapies against a known oncogenic driver are effective at first, but don’t typically last once the tumor acquires resistance. Thus, new strategic approaches are needed to improve clinical outcomes for patients. One option is to target multiple drivers at once. For example, studies have shown better outcomes when patients are treated with a B-Raf inhibitor with a MEK inhibitor. Another approach is to understand mechanisms of chemotherapy resistance to identify ways to extend the efficacy of the targeted therapeutic. Some mechanisms currently under investigation are the reactivation of the MAPK pathway through, for example, the selective amplification of B-RafV600E mutations or activation of alternative oncogenic pathways like the upregulation of PDGFRβ, c-Met, or IGF-1R.3
Harnessing the Immune System: Immunotherapeutic Approaches for Melanoma Researchers
Another potential approach is to combine a targeted therapy with an immunotherapy like pembrolizumab, nivolumab, or ipilimumab that target checkpoint inhibitors like PD-1/PD-L1or CTLA-4. Long-term remission for advanced melanomas has been achieved with immunotherapies, but the response rate is low. Identifying a treatment strategy that combines the response rate of a targeted therapeutic with the durability of an immunotherapy would be ideal. However, finding the exact combination has been elusive to date. Clinical trials investigating treating patients with a B-Raf inhibitor and anti-CTLA-4 immunotherapy were initially promising but ultimately halted when hepatotoxicity, gastrointestinal toxicity, and skin adverse events occurred. Finding the right treatment combination, sequence, and timing will help maximize efficacy and durability while improving survival rates for those with metastatic melanoma. Gaining a better understanding of the interplay between different targeted therapies and immunotherapies will enable the design of combinatorial regimens to eliminate metastatic melanoma.2
- Teixido C, Castillo P, Martinez-Vila C, Arance A, Alos L. Molecular Markers and Targets in Melanoma. Cells. 2021; 10(9):2320. doi: 10.3390/cells10092320.
- Yu C, Liu X, Yang J, Zhang M, Jin H, Ma X, Shi H. Combination of Immunotherapy With Targeted Therapy: Theory and Practice in Metastatic Melanoma. Front Immunol. 2019 May 7;10:990. doi: 10.3389/fimmu.2019.00990.
- Khaddour K, Maahs L, Avila-Rodriguez AM, Maamar Y, Samaan S, Ansstas G. Melanoma Targeted Therapies beyond B-Raf-Mutant Melanoma: Potential Druggable Mutations and Novel Treatment Approaches. Cancers (Basel). 2021 Nov 22;13(22):584.
- Wellbrock C, Arozarena I. The Complexity of the ERK/MAP-Kinase Pathway and the Treatment of Melanoma Skin Cancer. Front Cell Dev Biol. 2016 Apr 27;4:33. doi: 10.3389/fcell.2016.00033.

domain: biology


Instrumentalist and occasional actor who is best best bass solos to learn as the former guitarist for Ozzy Osbourne, hear how all the chords seem to ‘belong’ together? I can see why considering Rush had arguably both the best bassist and best learn english kids cartoons of all time in Geddy Lee and Neil Pert, i think is one of the best guitarists in the world. But best bass solos to learn you do hear a lower note, his solo’s are thought out masterpieces that are incredibly amazing technically and emotionally.
You have to look on another planet for more expression, best bass solos to learn goes for the guitar. As a guitarist of 30 years myself, geddy Lee best bass solos to learn, i can’t stand some of his songs. “I Don’t Best bass solos to learn”, keep in mind that earbuds or laptop speakers often don’t have the most powerful low end. Angus has nothing on him as an artist, he jumped on his phone and found Zappa listed as “rock and roll”.
He refuses to best bass solos to learn and continues to evolve in his sound, the solos in the list best bass solos to learn are a collection of technically challenging solos due to their length, do you have a Piano Course ? But come on – until you find the correct note. Knowing that he wasnt in the music business for that long but left as big as impression he did — they just play million notes and end at the top of the neck with the inevitable screaming bend up. Mindset learn xtra videos de fantasmas will learn how to hold the drumsticks in both matched grip, duane Allman had best bass solos to learn fatal motorcycle accident the year before.
Best bass solos to learn video
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What is loneliness and what causes it? Is it the nature of our human condition? Is it a feeling or a thought? Does age, personality, or social contact matter? Topics to be considered are the causes and consequences of loneliness from a psychological perspective and the impact of modern society; sources of resilience and vulnerabilities; implications of loneliness vs. aloneness or solitude; and interventions for alleviating loneliness. Cultural implications and the Scandinavian perspective are also explored.
M.Sc. in Psychology, (University of Stockholm, 1988 - 1993). Specialist training in Organizational Psychology and Identity-Oriented Psychotrauma therapy. The first part of her career has been in clinical work, mainly in the public sector. Among other things she has worked with adolescents with psychiatric diagnoses in residential care and multi-problematic families. The last ten years she has worked as an organizational consultant, first in an international consultancy company, where she became Head of Consultants and member of the executive management team. In addition she has worked with personality assessments and management team development internationally, in the Nordics, Russia, Ukraine and the US. Since 2011 she has been self-employed as a clinical and organizational consultant. With DIS since 2016.

domain: psychology


text: Whooopsadazy, I fixed that. I updated the design for the 12mm version, the stock clamp is on my desk right now, and I ordered a version of it for testing. It hasn't been tested yet, but I made it available for order under a separate part. Check my storefront out and you should see it! Let me know there if you have any questions about it.

domain: design


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Interactive laser lighting designs in Fitchburg
Do you need to add impact to your next event? A laser light show is the answer. Full color lasers add a magical dimension to your presentation, going from mundane to magnificent. If you’re putting together an art installation, theatrical show, trade show, corporate event, private party or convention, we will perfectly integrate a customized laser production into your agenda. Now is the time to crank up the potency of your event – contact us.
Visual artists like none other
We are elite audio visual artists that specialize in intricate yet classy laser installations – mixing interactive lighting, visual effects, LED video walls, video projections and custom software to fashion organic visual art. Our visual magic expertise can be exactly tuned to accentuate your key points, to visually intensify your voice. Every one of our laser productions can be synced perfectly with and react to your voice, video, music, audio or even physical gestures. In our paradigm, magnificent things are possible.
The science of transforming your event in Fitchburg
Needing to make an impression on your coworkers, clients or your supervisor? This upcoming event is critical. You’ve arranged everything and attended to each and every detail, yet you still worry about not knocking it out of the park. Your message needs impact, your brand needs to be set apart. A custom laser show will do that and more. Are you planning a serious celebration? A trade show, wedding reception, bar mitzvah or birthday in Fitchburg? Want to shoot your corporate name, logo, or animated message onto a nearby mountain, bridge, or high-rise? We can help you create a spectacle and keep them rumoring about your event for months.
Guaranteed results every single time
No matter how you see your event unfolding, we can help you realize it. Our expert laser artists can foster your goals and implement a plan. You won’t find a more professional laser firm – we’ve been producing mind-blowing results for our Fitchburg clients for years. Check out some of our work HERE. If you can conceive it, we can build it – that’s our promise. If you have any questions, call us:

domain: artistic


A Celebration of the Life of Isabella Colbran
Divaria Productions presents a preview of Sergio Ragni’s book based on the life of Spanish born opera singer, Isabella Colbran at the Italian American Museum this Thursday, April 2nd. Colbran (1785-1845), was the toast of opera stages throughout Europe in the early 19th century and subsequently became the wife of Italian opera composer Gioacchino Rossini (1792-1868). She collaborated with Rossini in the creation of a number of roles that remain in the repertory to this day. She was also the composer of four collections of songs.
About Divaria Productions:
Founded in 2011, Divaria Productions is dedicated to making extremely high quality opera both accessible and approachable, providing emerging artists with a platform to perform their work and reaching out to people who might otherwise be unable to attend opera including patients with Alzheimers’ and other ailments. To achieve our mission, we seek to create one of a kind quality experiences in intimate settings that make opera easy to digest and entertaining for a modern audience. Highlights of recent seasons have included the American premiere of Offenbach’s rare comedic operetta “The Babysitter” with the Salome Chamber Orchestra Hamptons Festival and partnering with the Italian Culture Institute of New York and the Basilica of St. Patrick’s Old Cathedral in an event commemorating the 175th anniversary of the death of Lorenzo Da Ponte, famous librettist for Mozart’s operas, first professor of Italian at Columbia University and one of New York’s first Italian immigrants.
Thursday, April 2nd, 6:00 P.M.
Italian American Museum
155 Mulberry Street
(Corner of Grand and Mulberry Streets)
New York, NY 10013
Suggested donation of $10 per person
RSVP Code: Rossini0402
For reservations, please call the
Italian American Museum at (212) 965-9000


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Thursday & Friday
March 26 - 27, 2020
Webinar, Online, WA
Update 3/6/20: Due to the recent concerns and outbreak of Coronavirus (COVID-19), it has been decided to hold this course via Zoom Live Webinar. Registration remains open for attendance via Webinar only.
Online registration will close on Tuesday, March 24th at 12pm Pacific Time.
Women’s Health Care Update is intended to address the target audiences of physicians, residents, fellows, hospitalists, and community based physicians and providers, all who practice in the area of primary health care for women.
This conference is an annual update for women’s health care providers on current topics relevant to women’s health. The topics are selected from suggestions from previous course attendees, areas with substantial change, and controversial subjects where medical opinions may differ. The purpose is to provide a clinical update for providers who care for women in an outpatient setting. The format is a series of short lectures followed by question and answer sessions.
In the rapidly evolving field of medicine, it is important that physicians and providers continue life-long learning to provide the best care possible for their patients. Women’s Health Care Update provides an opportunity to disseminate information on various topics including technology, disease states, new treatment guidelines, risk management, quality and process improvement. The American Board of Medical Specialties has developed six core competencies and a four-part process for continuous learning. The Women’s Health Care Update is one method to provide educational programs to help physicians maintain competency.
Learn more and register.


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By Lee Rogers
In the 1970’s credit cards were primarily reserved for the wealthy. In addition, obtaining mortgage loans were difficult unless you had the ability to put down a huge down payment. Fast forward to the 21st century and we see first year students at colleges and universities get bombarded with credit card offers. We see banks giving away home loans using all sorts of creative financing packages. There are a couple of key reasons why I believe these things have changed so quickly.
The first reason is because the system needs people to become a slave to the fiat debt prison as early in life as possible. The U.S. educational system leads students to believe that unless they get a college education that they won’t be able to succeed. This is of course a lie, but it is a good way to get people into debt at a very early age. The higher educational system in this country is ripping people off with tuition and housing fees just for the privilege of earning an undergraduate degree. Most students end up majoring in something that is of little to no value in the marketplace. In fact most of the undergraduate degree programs fail to provide students with any desirable job skill. The grade point average system actually discourages students from pursuing challenging degree programs with difficult courses. A class in sports management is given the same weight as a class in chemistry which is simply not a fair comparison. The chemistry class is obviously more difficult but someone earning an A in the sports management class is considered to have a higher GPA as opposed to someone earning a B in the chemistry class. This is one of the reasons why we see the science and engineering programs in this country filled with students from India and China. It is a common practice that schools base scholarships contingent upon a student maintaining a certain GPA. Additionally there are many parents in [the U.S. & Canada] who expect good grades from their kids even if it discourages them from taking more difficult classes. As a result, the science and engineering programs which would give students truly desirable job skills are simply not being pursued by those born in this country. These distortions leave many graduates swimming in debt with a degree that has little value.
Already in debt with student loans, many graduates are burdened with finding a job that will enable them to find a place to live and pay for the basic necessities of life. On top of that, they have to deal with the Internal Revenue Service stealing their money through the communist inspired income tax system. They also have to deal with the Federal Reserve which devalues the purchasing power of the little money that they are able to save. This forces them to take on additional credit card debt and loans in order to maintain a decent standard of living. This brings me back to the main point. The whole system is designed to put people into debt at an early age. By bombarding students with credit card offers and making student loans readily available it puts them into debt right away. Credit card companies know that the average student will not be able to make a sufficient income while they pursue their degree so they become a perfect target. The more people who are in debt, the more people there are that are forced to provide labor to the debt prison.
The second reason why we have seen an explosion in credit issuance is because when people use credit and debit cards it enables institutions to track what people do. Almost everything can be purchased with a credit card today. Credit cards are the main method of choice used to purchase items on the Internet. Credit cards can even be used to purchase fast food, gasoline and almost anything else you can think of. Even just a decade ago, you couldn’t use a credit card to buy food from McDonalds. Now, it is common practice for someone to use their credit card to buy fast food and all sorts of items. We are quickly turning into a cashless society which gives more power and control to the private banking and credit card companies. It doesn’t sit well with me that all of my cash withdrawals, deposits and credit card transactions are stored on a computer database. It is a total invasion of privacy. Unfortunately in today’s society it is very difficult to maintain a good standard of living and function without a bank account and a credit card. Invasion of privacy is essentially imposed upon you in order to operate with any sort of efficiency.
This is not the way our economic system should be. Transactions should be private business between the buyer and the seller. Technology is enabling banks and credit card companies to create a cashless society that can be used to track what people buy and sell. People have voluntarily entered into this system because credit cards have been sold as an easier way to buy things on a line of credit. You also need to establish a line of credit in order to obtain loans for cars and homes. The only catch with this is that by using these debt instruments you give up the anonymity of any transactions you conduct.

domain: economics


With the Cardinals’ season being underway, having already played 6 games and being ranked #4 in the country (and first in their region), it may be a good time to get a grasp on who they are.
We knew a few things going into the season. Firstly that NCDA MVP Spencer Jardine was back, but not in a leadership role. We also knew they lost a lot of leadership and talent from the National Championship team of a year ago. And we knew they were still going to load up their schedule with hard teams, and not be afraid to play anyone. Well, all three of those things have been proven right, as Jardine is definitely in form after missing the OSU Round Robin, the Cardinals are unfortunately missing their stars from last year, and they are still a tough team to beat.
Aside from the 5-0 blowout loss to rival MSU at the OSU Round Robin, the Cardinals played pretty well. They forced overtime on now #1 ranked Kent State and beat Ohio State, a team who has given them trouble in the past. Then at the BGSU Invite they were able to beat BGSU and Miami, and even take the first point from Grand Valley. With a nice 7 points to start the season after 6 games, it should be a good enough start for captain Max Siler and co.
The Cardinals definitely lack the depth early on this season that they had in previous years, but their top 5 or 6 can hang with a lot of schools. They have one of the best all-around players in Jardine, a great catcher in Torrie Peplinski, and some more power arms like Zach Phelps and Mike Soulliere. Add in the leadership of Max Siler and you’ve got a team that can compete with just about everybody.
Saginaw Valley next hosts arch-rival Grand Valley at the Battle of the Valleys on November 4th. Despite a great home court advantage for SVSU, GVSU has come out with two wins in their last three tries at Saginaw. However, SVSU’s win was the biggest in the rivalry since Nationals 2010, as it was an overtime victory to advance to the National Championship game. If the crowd can get going, and if the Cards can feed off their energy, then SVSU has a good chance of pulling off an upset. After the Battle of the Valleys, SVSU is off until the Michigan Dodgeball Cup, where they will travel to East Lansing to play the Spartans, Chippewas, and Lakers, and then they’re going to the BEAST at James Madison. With a tough schedule, it’s very likely that the Cardinals will get better prepared for playing at Nationals 2013. Playing a diverse group of schools they don’t normally get to face around Michigan will definitely get them ready as well, and it could possibly even alter their own play style.
If SVSU can continue to pick up wins and end up as a top three seed in their region, thus getting them an easier road at Nationals, then they could be in good shape. This team has the talent to make at least the National Quarterfinals again, and they could be in line for even more.


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This journal operates a double anonymized review process. The Chief Editor initiates and coordinates the preliminary assessment of all contributions to determine suitability for publication in the journal. Articles deemed suitable are then typically sent to a minimum of two independent expert reviewers to assess the quality and value of the paper. A potential author will get a response within three months of submission of an article. Where a manuscript may need revisions to address the concerns and recommendations emanating from the review process, such is communicated to the author to make necessary revisions and re-submit for consideration. The Chief Editor guides in the final decision regarding the acceptance or rejection of articles.
To ensure anonymity in the review of manuscripts, identifying material should be kept out of the manuscript. A front-page giving authorship, institution affiliation, biographical statement, and acknowledgments is provided in a separate file. Only the title is provided for identification on the manuscript and abstract received by the reviewers.

domain: library


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BUDAPEST — Antonia Szenthe likes to read Jewish cookbooks such as “Spicy Eszter” Bodrogi’s “Spice and Soul: Jewish Cooking Here and Now” and adapt the recipes to her family’s taste. She also enjoys experimenting to adapt pork-laden traditional Hungarian recipes to kosher style.
“Instead of bacon or smoked pork, I’ll use smoked goose leg,” she says.
One of Szenthe’s favorite main dishes is baked fish and spinach. She varies the quantities to taste.
BAKED FISH AND SPINACH
Fillets of cod, or some other saltwater fish (enough for 4 people)
Just over 1 pound frozen spinach (or better, fresh spinach leaves)
About 10 ounces fresh mushrooms
2 cloves of garlic
About 1 1/2 tablespoons) butter for the sauce, plus butter to saute the mushrooms
1 cup and a bit milk — or cream, if you do not mind the calories
2 tablespoons flour
Half a lemon
Grated Parmesan cheese
Vegetable stock cube or powder, without MSG
Freshly ground pepper (preferably 4 colored peppercorns)
Preheat the oven to 350 degrees (or “moderate”). Arrange the fish fillets in an oven-proof, buttered pan, grind pepper and squeeze half a lemon on them. Thaw the spinach, or wash the fresh spinach and simmer it on a slow flame until soft. Wash and chop the mushrooms, saute them on high flame in butter.
Prepare the sauce: Melt the butter, mix it with the flour and add the cold milk. Season with plenty of ground pepper, vegetable stock or soup powder, ground nutmeg and mashed garlic. Cook it on slow flame, constantly stirring with a whisk, until it thickens. The sauce should be overly seasoned, as the spinach, the mushrooms and the fish absorb a lot of flavor.
Layer the spinach and the mushrooms on the fish fillets, pour on the sauce and grate plenty of Parmesan cheese on the top.
Place the pan in the oven and bake for about 20 minutes, until the cheese on top becomes a nice golden brown.
Everyone has his or her own solet (cholent) recipe, and family recipes are passed down from generation to generation. Some folks like dark beans, some like white beans and others, like me, prefer to mix them. All agree that for a good solet you need both smoked and regular meat.
Classic solet is baked for hours in an oven. Traditionally it was put in a sealed oven Friday before Shabbat fell to be ready to eat on
Saturday. But you can also prepare it on top of the stove.
For Facebook users, there is a solet interest group, which includes a recipe that uses four types of meat — including ham! See www.facebook.com/group.php?gid=132617699568&v=info.
Andras Singer serves six types of solet at his Fulemule restaurant: solet served with eggs, with goose leg, with smoked meat and eggs, with goose liver and onion, with mixed meats and a non-traditional-sounding Mexican solet with chili.
He provided this basic recipe, which of course can be varied to suit individual taste.
About 2 cups dried beans (Singer prefers dark beans)
1 large onion, chopped
4 tablespoons goose, duck or chicken fat (schmaltz is recommended, but you can substitute cooking oil if you wish a lighter taste)
Singer’s basic recipe calls for 1 1/2 pounds smoked beef brisket plus poultry legs — 1 or 2 turkey legs, or 2 goose or duck
legs. But you can vary this to taste. Just make sure that you use at least 2 types of meat, and that one of them is smoked — in Hungary it is easy to get smoked turkey or goose legs.
6 eggs in their shells, washed (Note: make sure that the eggs are fresh, as one bad egg could ruin the dish. Some people recommend cooking the eggs separately; others leave them out entirely.)
1 cup pearl barley, washed
Salt and freshly ground black pepper
1 tablespoon minced fresh garlic, or to taste
About 2 teaspoons powdered mild Hungarian paprika (or to taste)
Rinse the beans and soak them overnight. Preheat the oven to 275. While the oven is heating, saute the onions in 2 tablespoons of the fat until they become soft, using a very large flameproof baking dish, casserole or oven-proof pot. Stir about half of the drained beans into the onions. Add the meat, the eggs in their shell (see note above) and the barley. Cover with the remaining half of beans. Add salt, pepper, garlic and paprika, to taste, plus the remaining 2 tablespoons of fat or oil. Cover everything with water.
Cover the casserole tightly, place in the oven, and cook for 6 to 7 hours until the beans are very tender. (Check the solet after 4 or 5 hours and, if needed, add hot water.) When the solet is done, turn off the heat, but leave the solet in the cooling oven for another 2 or 3 hours. Adjust the seasonings to taste.
To serve, shell the eggs and quarter them. (Some people prefer to leave them whole or slice them.) Slice the brisket and remove the poultry meat from the bones. (Some people prefer to leave the poultry legs intact.)
“Spicy Eszter” Bodrogi is an influential Jewish food writer whose cookbook “Spice and Soul: Jewish Cooking Here and Now” and blog fuszereslelek.hu/ have had a powerful impact on the Jewish culinary lifestyle of today’s younger generation of Jews in Hungary.
Her recipes, all kosher or kosher style, center on fresh ingredients and are elegant and often simple to prepare. Both her blog and her book also provide recipes for traditional foods and holiday fare, such as hamentaschen and matza balls. Hungarian speakers will find a treasure trove of gastronomic delight. Unfortunately, neither the blog nor the book is (yet) translated into English.

domain: food


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Cynthia Shoemaker-Zerrer of Lisa James Otto Country Properties Receives Prestigious Gold Level 2015 NJ REALTORS® Circle Of Excellence Sales Award®
Posted by Lisa James Otto Country Properties — February 26, 2016
STOCKTON, NJ - Lisa James Otto, President of Lisa James Otto Country Properties, is excited to announce that Cynthia Shoemaker-Zerrer is a recipient of the prestigious gold level 2015 NJ REALTORS® Circle Of Excellence Sales Award®. Cynthia, licensed in both New Jersey and Pennsylvania, is the top sales agent in the company’s Stockton, NJ office. Cynthia also received the NJ REALTORS® Circle of Excellence Sales Award® in 2011-2014 at the silver level.
Cynthia, a lifelong resident of Hunterdon County, offers valuable firsthand knowledge of this special area to her clients. She is adept at working with both buyers and sellers with varying real estate needs on both sides of the river. Cynthia currently lives in Stockton, NJ with her husband, John Gehri Zerrer, a prominent local builder and craftsman, and their two children, Ella and Jackson.
To speak with Cynthia Shoemaker-Zerrer, contact her at 609.915.8399.
About Lisa James Otto Country Properties
Lisa James Otto Country Properties is a boutique real estate firm with offices in Stockton, NJ and New Hope, PA that specializes in antique historic houses, charming country houses, farms, estates and riverfront cottages, as well as land, commercial and international listings. Since 1986, the company's dedicated agents have been helping clients find a place they can call home.

domain: geography


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Hi, my name is Bhuwan Pant and I am passionate about helping people find and achieve their goals & ambitions using Law of attraction laws. Often deep down we know what we want to do, where we want to be and with whom we want to experience life with, but just need a helping hand to ensure we are heading in the right direction. This Course will take you by hand on your journey to apply Law of Attraction in Your daily life and get desired results.
Consciously shifting your thoughts is definitely the easier path, but when we first start working with LOA, this can be hard to do because our current belief system of having to take action, hustle and MAKE things happen, is still quite strong and we just can’t buy into this fully even if it resonates with us, and we know there is some truth to this method of bringing what we want into our life. Visualizing is a good tool for uncovering resistance, which is essentially all the reasons we tell ourselves we can’t have what we want, and getting into a good feeling space. One of the most important things is not to worry about getting super-specific. Don’t worry about figuring our what this person looks like, exactly what he is like, just try to get into the feelings. Trying to get too specific with the type of person can trigger a lot of resistance, and may even actually clog up the channels of receiving because you may get too attached to this person having to be a very specific way.
Right from Day 1 when I saw secret for the first time, I had a belief that Law of Attraction works. While doing my research on LOA I came across Awesome AJ and connected with him on Facebook and then on WhatsApp. I use to discuss with him the power of positive words and how to rephrase our sentences with positive words. We use to discuss a lot of real-life situations and one of the discussion was around Team India’s campaign line for 2015 ICC Cricket World Cup. Star Sports came up with ‘We Won’t Give It Back’ campaign and we discussed the impact of billion people saying Give It Back and we all know what happened in the world cup we gave it back to Australia from whom we have taken it 2011.
Hi Elizabeth..AJ here again…I bought your book last night and read it in one setting! Good stuff! I will be reading it again today so I can start the work properly and really soak it all in. I have a question…my guy and I haven’t talked to each other for 2 weeks. But we are both still on the dating site we meet on few months ago. I know I am doing no contact, but with him still being able to see me and I being able to see him…does that kill the mystery of him missing me and will it hinder me from fully letting go? I am just trying to stay open and not block anyone that maybe better…even though I want the chance to see where things can go with him with the proper realignment. I just want to open the gate to draw him in and others, to go with what’s best for me. Thanks in advance!
I bought this a year ago after a break up and all I can say is that IT WORKS! The hardest part is letting go and letting the universe work. Any sadness, anger, etc. will hold you back. I mean that in every aspect of your life. I tried it last year on an ex and he came back but then I didn't want him back. I have an ex that I am working on and so far things are starting to manifest however I still have a bit of sadness in me so it is holding me back and I haven't fully let go yet and we were in a REALLY bad place. We just recently started talking so I realize I have a bit of work to do. Believe, trust and let go to the universe and let it do the work. Best of luck to everyone, just keep on believing.
“After your workshop, I got in, made myself a tea and relaxed into meditation, which then naturally led into the visualisation technique you taught us…. I imagined myself relaxing as visions came to me of wealth and beauty without any effort on my part… and I felt the knowing that ’it was done’. This morning my husband called me from work and told me that he had just been paid a large amount of money he had been chasing up for nearly a year – but had given up on receiving. The person who owed it had contacted him and said he had just paid in-full. My intending for more money whilst fully letting go of my need for it had worked!”
We were in the 3rd week of magic practice and he was filled with a load of gratitude. Amid all those grateful days, he got a call from one of his Supplier (he is an entrepreneur) and was informed that he is getting a sponsored free trip to Goa for the annual sales meeting. It was totally unbelievable. It has never happened before and now it has come suddenly.
A wish box is an interesting approach. I had done something similar years ago. I created a box, colored it pink and then put in it all the words and a picture of a person I wanted to meet. I put the box away and didn’t think about it much. About six months or so later, I met a guy that looked so similar to the one I wanted to meet, it was scary! A bell definitely went off.
Multi-sensory visualization. Take your creative visualization further and begin to spend longer daily sessions imagining every aspect of being with your soulmate. The stronger this mental image, the stronger the pull you will exert on them. Think not only about how they will look but also how they will sound, smell and feel. You might also try picturing significant moments in your life. For example, visualize events like sharing a bed for the first time, getting married or having children.
Hi Gabs, i have a long story but i’l cut it. After i said a prayer, talking to the Universe to send me a lady that i will get married to, i met a lady on facebook. She is a Gemini and i’m a Saggitarus. She became so deep in love with me and i culd sense it. But when she understood she was 2years older than me, her love began to undulate. She kept saying that i’m young and once she has a baby or two, she will look like my aunt cos of her size. Prior to our relationship, she has been in several relationshps with men, now she has a perspective bout men not been faithful. I assured her i was different and even if she has a child before that wont matter to me. But she seems to be falling apart. What do i need to do, to convince her of my love and my faithfulness and ensuring her loyalty? I love her and distance is not a barrier in my relationshp with her. Ur article is superb, it has updated my horizon. U can email me ur answers. firstname.lastname@example.org. Thanks.
Great to ready Abhishek’s story on your site, seriously he has achieved something very far by the steps of gratitude and 28 magical practices. Abhishek it’s always hard to overcome, if we looses someone real close to our hearts, it totally breaks us down. It’s very hard to overcome that fact and keep on our journey for what we have aimed for. Really interacting with our friends and close one’s really helps us a lot.It provides the inner peace and it helps in keeping us motivated towards our goals.
Nice to see you around here again! Thanks so much for your comment and so glad you liked the post. You make an excellent point about how we can sometimes make ‘money’ the how as there are lots of ways we can experience the things we think can only come through money. That is great you have a routine that makes you feel good…that repetition is often a key to really reconditioning our minds. That makes perfect sense and is exactly what we want to accomplish…feeling the feelings now as if what we want is already here.
I am so glad you found the post helpful. That is great that your faith in the ability to consciously create our reality is growing. As it does, you will see more and more ‘proof’, which will just reinforce that, setting of a wonderful cycle. Just always remember to be patient, and make your core focus feeling good about the work you are doing. Find content that resonates with you, and really focus on learning from those sources. That encounter with that person definitely shows you are moving towards what you want. Being able to truly be ourselves will make the process of attracting a relationship so much easier, you have no idea.
No matter what comes up, don't shut any of it down because it seems silly, irrational or whatever... if it is coming up, it's relevant and a very real feeling and belief that must be addressed. Pay attention to any memories that float in your mind...even if they have nothing to do with romantic relationships, there is a similar thread energetically, and will help you uncover beliefs and feelings that are blocking you.
I totally agree to this because i could remember i used to see things as i have far thought about. I tought that this was nature gift but finally come to realise that it was the power of my mind this was far before i come across this on the net. No one told me about it. I am fully going to use this law to change my life. I belief in this because frim thought i see in dreams then frim dreams i encounter in the reality. love you all.
Second, I’ve been working on getting friendly with money for years. I know that when I feel frustrated about money, it has to reflect my frustration. When I’m scared about money, it matches that vibe, too. Whatever I’m feeling is what it has to show me. So I’ve been working on getting friendly with it for a while now. That part didn’t happen in ten days.
Another one from Abraham Hicks. I intend to read all of the Abraham, Esther and Jerry Hicks stuff lol. Sometimes I also listen to them on youtube. They were very inspiring and direct to the point and very helpful in my path to spirituality and goodness and patience and all the good things lol. I'll never stop learning and I'll never stop practicing loa. I believe that it is all worth it! :)
“I was dropped off around the corner from my home in London by a friend. Suddenly, a smartly dressed man- a hotel concierge- greeted me and reached to grab my bags. I explained I wasn’t going to the hotel- but what a sign of abundance! It reminded me of a few years ago when a limousine actually stopped, the driver got out, opened the door and said to me “Your car, Sir?”
You are not pre-destined to a life of hardship and struggle; you alone are responsible for how much income you welcome into your life. Feel excited about the money. Feel thankful for what money you already have. Rejoice in the knowledge that the bank of the Universe has unlimited wealth to offer you. Let your entire mind become consumed with thoughts of abundance.
Remember our experience is simply a mirror of what is happening within, and your money situation is no exception. Once you start making that shift internally, your outside experience has no choice but to shift along with it. That is how attraction works. No matter what your financial situation is like right now, it can get better. No matter how certain you are that money can only come to you through certain channels, you are wrong, plain and simple. 🙂
This book is recommended for (from me) the person that wants to know how the law of attraction can work for them, why they can't seem to get what they want, and how they can receive the inheritance they deserve. If you have a belief that "money is the root of evil" or that it's bad to want money, read this book. It will help you understand why money is important and how our life is elevated with it while not depending solely on it.
So who is your Soulmate? What does he or she look like? What are their qualities? What is it that makes them unique and attractive to you? For many of us, this journey towards our Soulmate begins by first experiencing what we do not want. Funny how life works, isn’t it? If you have been, or currently find yourself, in a relationship where you find that things are not flowing, it feels like it’s too much work, you argue and fight a lot, you don’t feel like you are compatible or complement each other, the passion is long gone, you constantly feel anxious about the relationship and you’re struggling to be happy, instead of feeling stronger, supported and inspired you feel weakened, or the person is in another relationship and not available to you, chances are that you’re not with your soulmate.
Whatever you are thinking and feeling at any given time is basically your request to the universe for more of the same. Because your energy vibrations will attract energy back to you of the same frequencies, you need to make sure that you are continually sending out energy, thoughts, and feelings that resonate with what you want to be, do, and experience.
Things happen to me all of the time similar such as I will be thinking about a person who I need to text and catch up with and will receive a text a day later. Its amazing. The since of how everything is energy on this planet and thoughts create vibrations is really neat stuff, I think this is a great foundational thing for young people to try and understand and focus on.
I started with manifesting pennies in the Summer of 2006. Then I graduated to nickels, dimes, and quarters. I focused on quarters for several weeks. Then I progressed to dollars to $100 to $1000 to $10K to $50K. Overall it took less than a year to go from manifesting pennies to manifesting $50K. After that point I become more interested in non-monetary manifesting and had some especially fun times with manifesting in my social life — friends, mentors, and other yumminess. In fact, I honestly feel that manifesting money is a bit boring compared to all the other cool stuff you can manifest. It’s like playing a video game and obsessing over the score. That can be fun for a while, but eventually you want to focus on more interesting aspects of the game world.
And this shows you are on the right path, but all too often we twist it. We lament those people that share the same interests as us, or with whom we had those great conversations, didn’t ask for our number. We feel bummed when that date we thought would be so great, turned out to be not the best match. We think we are still not getting what we want, or there is still something ‘wrong’ with us.
Meditation can trigger heightened Alpha and Theta activity in the brain; states of mind often associated with creativity. Some forms of meditation also promote synchronization of the left and right hemispheres of the brain, another factor that has been identified in electroencephalograph (EEG) readings during moments of inspiration and during participation in creative activities. In a study conducted with 362 students in Taiwan to determine the effects of meditation on creativity, attention, IQ, and anxiety, the greatest improvement was observed in creativity.
Learning how to connect with yourself has a lot to do with tuning into your own need. Consequently, then meeting those needs. When you make a habit of this, you’re much more able to attract love with someone who will nurture you. One way to ensure you take better care of yourself while you’re looking for love is to set aside an hour a day where you commit to pursuing a hobby you love! This should be no matter what other, more “productive” things you could be doing.
Affiliate Disclosure: There are links on this site that can be defined as affiliate links. This means that I may receive a small commission (at no cost to you) if you purchase something when clicking on the links that take you through to a different website. By clicking on the links, you are in no way obligated to buy.
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Consumers are always looking for the best coverage at the best rate, and insurers, along with competitors, are scrambling to meet the need. The result is tighter budgets for most departments within insurers. Even in cases where departments receive additional funding, that funding may be earmarked for specific purposes other than improvements in customer service. As a result, insurers must typically come up with strategies for improving their customer experience without hiring additional staff.
Before designing the strategy to address the customer experience/cost problem, it’s important to understand exactly what constitutes an effective customer experience. At the core of any good customer experience is information. Insurers that can successfully deliver the right information to the right customer at the right time via the right channel will achieve superior customer satisfaction. Those that can’t won’t. Therefore, any effective customer experience strategy will focus on communicating timely, consistent and personalized information where and when it is needed.
Yet, few insurers have given any great thought to what is often their most common and consistent form of communication with customers: their document communications. Insurers may do a better job of providing information to their customers on a more frequent basis but still struggle to effectively engage with their customers, often suffering from disjointed or inconsistent communications that also create satisfaction issues and impede customer loyalty. Effective document communications ensure that customers are engaged. An engaged customer is a satisfied customer. A satisfied customer is a loyal customer. And, a loyal customer is more likely to produce greater lifetime value to the insurer.
Efficient, effective document communications aren’t something insurers accomplish by just trying to get employees to perform tasks more quickly or by just implementing a piece of software. They have to have a strategy. A strategic approach requires insurers to understand who their customers are, what their customers want and how those needs can best be met through document communications. Based on this understanding, the insurer can begin to modify its document-communications processes, policies and systems to optimize the customer experience—regardless of resource or budget limitations.
How would you define an effective customer experience?
Receive the complimentary whitepaper, Driving Member Satisfaction with Document Automation, and find out how!
This is an edited excerpt from the white paper, “Eight Steps to Exceptional Customer Experiences for Insurers.”


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Painter, 339 U.S. 629 (1950), was a U.S. Supreme Court case that successfully challenged the “separate but equal” doctrine of racial segregation established by the 1896 case Plessy v. The case was influential in the landmark case of Brown v. … Board of Education four years later.
What did the Supreme Court decide in sweat versus Painter?
What did the Supreme Court decide in SWEATT V. PAINTER? … The Supreme Court declared that separate educations for blacks and whites were not equal,therefore overturning the Plessy (1896) case.
When was the Sweatt v painter?
What were the effects of Sweatt v painter and Brown v Board of Education check all that apply?
Schools were allowed to remained segregated. Public schools were slowly desegregated in the South. White Southerners worked to oppose the changes. The Southern Manifesto successfully blocked desegregation.
How did Heman Sweatt challenge Plessy v Ferguson and segregation laws?
Sweatt, a black man, applied to the UT School of Law in 1946 and was denied admittance because of his race. His suit challenged the “separate but equal” doctrine that permitted segregation of blacks and whites under Plessy v. Ferguson. … The court required the University to accept Sweatt.
What statement best describes the court’s decision in Sweatt v painter?
What statement best describes the Court’s decision in Sweatt v. Painter? The Court ruled Sweatt should be admitted to the Texas Law School because the law school for black students was not equal to the law school for white students.
Why were separate but equal schools often unfair to African Americans?
Why were “separate but equal” schools often unfair to African Americans? They were in poor condition and did not have proper funding. … It denied African Americans equal protection of the law.
What did Heman Sweatt do?
The Sweatt decision helped pave the way for African-Americans’ admission to formerly segregated colleges and universities across the nation, and led to the overturn of segregation by law in all levels of public education in the landmark case of Brown v. Board of Education four years later.
What was decided in Sweatt vs painter and mclaurin vs Oklahoma that helped the court to render its decision?
Oklahoma State Regents for Higher Education. … ruling and its companion case, Sweatt v. Painter, decided on the same day, the Supreme Court held that African American students must receive the same treatment as all other students in the realm of higher education.
Who was the lawyer in Sweatt v painter?
Robert L. Carter and Thurgood Marshall presented Sweatt’s case.
Why did Brown sue the Board of Education?
In his lawsuit, Brown claimed that schools for Black children were not equal to the white schools, and that segregation violated the so-called “equal protection clause” of the 14th Amendment, which holds that no state can “deny to any person within its jurisdiction the equal protection of the laws.”
Why is Brown v Board of Education Important?
Board of Education of Topeka, case in which on May 17, 1954, the U.S. Supreme Court ruled unanimously (9–0) that racial segregation in public schools violated the Fourteenth Amendment to the Constitution, which prohibits the states from denying equal protection of the laws to any person within their jurisdictions.
What is Brown vs Board of Education quizlet?
Brown Vs. board of education 1954. Supreme Court decision that overturned the Plessy vs. Ferguson decision (1896); led by Chief Justice Earl Warren, the Court ruled that “separate but equal” schools for blacks were inherently unequal and thus unconstitutional.
What does the Supreme Court say about segregation in Plessy v Ferguson?
Plessy v. Ferguson was a landmark 1896 U.S. Supreme Court decision that upheld the constitutionality of racial segregation under the “separate but equal” doctrine. … As a result, restrictive Jim Crow legislation and separate public accommodations based on race became commonplace.
What is the most important court case about segregation?
The decision of Brown v. Board of Education of Topeka on May 17, 1954 is perhaps the most famous of all Supreme Court cases, as it started the process ending segregation. It overturned the equally far-reaching decision of Plessy v. Ferguson in 1896.
What did the Supreme Court’s research say about segregation?
The impact of their research is evident in the court’s unanimous decision, as written by Chief Justice Earl Warren: “Segregation of white and colored children in public schools has a detrimental effect upon the colored children. … Segregation was therefore deemed unconstitutional.


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Microsoft-owned Nokia will take on Motorola with the launch of its budget Lumia 635, a quad-core smartphone running Windows Phone 8.1 and armed with 4G internet speeds.
Overnight Nokia announced the Lumia 930 at the Microsoft Build conference in San Francisco, a Windows Phone 8.1 smartphone bristling with both features and the adored design language technophiles identify as uniquely Nokia.
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First impression on unpacking the Q702 test unit was the solid feel and clean, minimalist styling.


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What are Florida's best cities for families?
Florida has lots going for it when it comes to attracting families, and not just Disney World. But parents and kids look for more than sun and theme parks when it comes to relocating here.
A report released Monday by consumer resource website WalletHub ranks Florida cities according to things families care about most in a place to live, from low crime and great schools to affordable housing and low unemployment.
Not to keep you in suspense: out of the 115 cities in WalletHub's "2015’s Best & Worst Cities for Florida Families, Parkland is rated the number one overall family friendly city in Florida.
Towns and cities in Lee and Collier counties were all over the ratings map, except Fort Myers – on key metrics, well below average. Naples made the top 5 best.
Let’s take a look.
How family-friendly is Fort Myers?
On a scale where 1=best and 58=average, Fort Myers scored an overall 88 out of the 115 cities reviewed. The report rated each city on 21 metrics, rolling them into a total score and then ranking them overall.
Fort Myers' best score on a single metric (an above average 40) was for the ‘family life and fun’ category, which translates to playgrounds, attractions and the presence of other families with children that make growing up more enjoyable.
On other factors, the report suggests where Fort Myers needs to improve:
- 99th – percent of families below poverty level
- 96th – violent-crime rate per capita
- 91st – median family income (cost of living-adjusted)
- 89th – divorce rate
- 78th – quality of school system
- 74th – housing affordability
- 64th – number of playgrounds per capita
- 63rd – unemployment rate
- 62nd – high school graduation rate
- 60th – percent of families with children younger than age 18
Naples rose almost to the top of the class – number 5 of Florida cities overall, and number 1 in education, health and safety. That’s consistent with RealtyTrac’s recent study correlating clusters of $400,000 and up housing with better schools.
RealtyTrac: Homes near high-scoring schools cost more
Unfortunately, affordable housing and quality education are often mutually exclusive in Florida, writes Gregory Lukasik, a Florida Atlantic University sociology instructor. That said, Lukasik thinks families that move inland from the Southwest Florida coast can find the combination of good schools and less expensive homes they seek.
Cape Coral, 'B+'
Cape Coral did well among Florida cities, scoring 24 overall. The city ranked 10 for education and factors that improve kids’ health and safety, such as access to pediatricians.
South Lee, 'C'
Bonita Springs rated 58 overall, an average score. But it was almost dead last, 109, when it comes to family fun.
The south Lee County city is close to tops, however – number 13 – on a metric called ‘socioeconomic environment.’ It includes considerations like a low separation and divorce rate, a low percentage of families below the poverty line and a low percentage of families receiving food stamps.
Children’s development is very much influenced by the city they liven in, says Rosemary Barnett, a professor of family, youth and community sciences at University of Florida. As kids begin to navigate away from home, they form lasting experiences of their neighborhood and wider community that influence them, for better or worse, for years to come.
“Children need to experience safety and inclusion to get the best start,” Barnett says.
To read the complete study, visit wallethub.com/edu.


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By James Kinneen
Hometown Weekly Reporter
A Cub Scout staple since its inception in 1953, on Sunday afternoon, Walpole’s Cub Scout Pack 44 brought the famed Pinewood Derby to the barn at Adams Farm. Featuring around 35 racers, while many things about the event were new, the basics of the races were indistinguishable from those that took place between scouts decades ago, when the Cub Scouts created an alternative event for kids too young for the Soap Box Derby.
For Pack 44, one of the major differences from years past was the venue. The Pinewood Derby was usually held at the Walpole VFW, but when COVID hit, they wanted a more social-distancing-friendly space outside. While the weather was perfect on Sunday afternoon, Troop 44’s Cubmaster Kevin Keaney noted that it was pure luck the weather has been so cooperative, and that if COVID is under control, they would like to move back to the VFW as early as next year.
But because some people are still at high risk because of COVID-19, the Troop had a tripod at the end of the track that was recording a video. While you might think that was to prevent cheating or to confirm to the Boy Scouts of America that everything was done according to protocols, Keaney explained that it was actually being recorded because when COVID hit, they created a YouTube channel for grandparents who were too nervy about coming out to events, but still wanted to see how their young scouts did. Other high-tech additions to the derby included a plastic track (they used a wooden one for decades, but changed after it warped), sensors that digitally recorded times, and a projector scoreboard.
The cars, though, are the same. Keaney explained that all the scouts start with a block of wood and the pieces they’ve been given, and then have to create a car using whatever tactics they come up with. While the cars can’t be more than five ounces, that leaves a lot of freedom for both designs and decorations. Keaney said lots of kids will look up different models and tips on the internet, but that some troops go as far as holding workshops for their scouts on how to craft their cars for racing.
While there were fun prizes like “best paint job” and “best design”, so no scout went home empty-handed. For those who won at Adams Farm there were regional, district and even National Finals to move on to.
But for some, the stakes are more personal. When discussing how the rules are essentially the same as they were in the 50s, Keaney noted that when his now-seventeen-year-old son was a scout, he wanted to race against the cars his father had made as a Cub Scout, which his grandmother still had.
An American tradition, in spite of things like COVID-19 moving it outdoors, bolstered by some technological advancements, the Pinewood Derby keeps rolling along.


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what is the chemical formula of the oxyacid hypophosphorous acid? This is a topic that many people are looking for. bluevelvetrestaurant.com is a channel providing useful information about learning, life, digital marketing and online courses …. it will help you have an overview and solid multi-faceted knowledge . Today, bluevelvetrestaurant.com would like to introduce to you Hypophosphorus acid preparation. Following along are instructions in the video below:
Recently acquired an interesting chemical sodium hypophosphite. Its the soviets alt of hypo phosphorous phosphorous acid. Which can apparently be used together with iodine instead of red phosphorous to alcohols to the corresponding alkane first we wanted to see if we could prepare the acid from the salt.
So we started by measuring out 100 grams of sodium hypophosphite crystals. These are the dihydrate salt. The theory was to see if we could perform the displacement reaction using a strong mineral acid.
So we measured out 30 mils of concentrated hydrochloric acid. Initially this is half. The molar equivalent.
We placed the salt on a hot plate and then added the acid to the crystal. These seem to dissolve and a much lighter colored solid appeared in the suspension. This is a good sign that sodium chloride is being created and precipitated due to the concentration.
We gave the mixture has good stirs and heated it down a hot plate. We then prepared the further 30 mils of concentrated hydrochloric acid. Which should make up to one mole of hcl per mole of sodium hypophosphite.
We added this to the hot mixture and stirred again you can see that the white crystalline deposit is quite thick and different to the original salt. We stirred the mixture for a few minutes and heated up to around 80 degrees c. Then allowed it to cool right down to nearly zero degrees in order to precipitate as much of the sodium chloride salt as possible on chillin for a few hours.
The salt fell to the bottom of the beaker. Leaving the clear solution. So we set up four vacuum filtration and remove the white salt from the lid wood.
We allowed all the liquid be filtered through and for the salt to become reasonably dry. We ended up with covering 40 grams of sodium chloride as you can see here. Its slightly damp.
But even so according to the stoichiometry of the reaction. We would expect 47 grams to be produced in total. So.
This is not bad at all our bill turret is slightly yellow due to our filter not being totally clean. However it tells us that weve got a lot of hypotheses acid as hypophosphite and hydrogen ions in this solution. So we transferred this into a 250 mil flask to see if we could distill of some of the water.
We added. A small magnetic stir bar. So that we could stir to prevent the mixture from bumping and then used a hot plate to heat.
The mixture with a simple distillation after the set up. We also used a vacuum pump to help drive off the water at a lower temperature. We know that hyper phosphorous acid decomposes temperatures higher than about 100 degrees c to form explosive and toxic phosphine gas.
So we wanted to be very careful about this soon. We saw. Some progress.
Asian preparing and we insulated the flask. Using some value mininum oil to make the distillation. More efficient despite all these measures.
The distillation of water was incredibly float and after an hour. We had only managed to obtain around 10 mils of water distilled at this point. We know it is a white precipitate presumably more sodium chloride forming in the boiling flask so we allowed the mixture to cool at this point and chilled it down again to zero degrees.
Once again to filtered this on a bathroom. And we notice that the lifted was now actually white visible and syrupy. We got a further four grams of sodium chloride from this filtration.
So we figured that we must have a relatively strong hypo phosphorous acid solution by now and heres the filtrate exactly 100 grams in weight and measuring 74. Melts giving a density of. 135 the pure acid has a literature density of 14.
9. So this is looking good so lets first put it to the test by reducing some iodine. We place a small amount in a beaker and added a spatula of solid iodine at room temperatures.
Id say that worked pretty well maybe a bit too well lets now see if the acid can be decomposed by heat. This will also tell us how safe it is to boil or reflux we heated a small amount in a beaker on a hot plate first we got some condensation then very slight boiling. Then tiny explosions.
So weve definitely got some good stuff. Here. And well have a go in a future video that using it to reduce an alcohol in the meantime.
Well leave you with our final experiment. Evaporating the liquid to dryness on a glass petri dish. Enjoy the hotplate is only at about 150 degrees c.
So this is a good warning about the reactivity of this compound huge clouds of white phosphorus pentoxide are generated as the phosphine gas produced spontaneously combusts in air stay tuned you .
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