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Too Much Time On Facebook Can Lead To Depression
No surprise there-From photos of that incredibly fit friend to new baby announcements and vacation gloaties, Facebook can sometimes be a source of anxiety and envy.
Now, a new study reveals using the social media site could lead to symptoms of depression.
University of Houston researchers found that Facebook users felt depressed when comparing themselves to others on the site.
Read Full Story: http://philadelphia.cbslocal.com/2015/04/08/no-sur...


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Mixed-race family 'forced out of their home' by 'White Only' pool sign - and now landlord faces paying them damages
A sign denoting that a public swimming pool was 'White Only' forced a mixed-race family to move out of their home.
The claim was heard by a civil rights panel which today upheld its decision that the posting of the sign discriminated against a black child who had previously used the pool.
The landlord who posted the sign, which she has previously claimed was an antique put up for its historic value, could now have to pay damages to the girl's family.
Discriminatory: A civil rights panel has upheld its decision that this sign is oppressive to minorities
The Ohio Civil Rights Commission voted 4-0 against reconsidering its finding from last September that the sign put up by Jamie Hein violated the Civil Rights Act.
At the hearing the girl's father, Michael Gunn, described the humiliation suffered by him and his daughter after the sign appeared by the pool near their apartment complex in Cincinnati.
'My initial reaction to seeing the sign was of shock, disgust and outrage,' Mr Gunn said.
His family moved from the complex - also owned by Heim - soon afterwards, and he told the panel that his daughter was upset to hear the move 'was in a way related to the colour of her skin'.
They filed a discrimination charge with the commission, which said in its earlier finding that the Gunns had moved homes to 'avoid subjecting their family to further humiliating treatment'.
'Shock, disgust and outrage': Michael Gunn (pictured with Elizabeth Brown, executive director of Housing Opportunities Made Equal) told the panel of the horror he felt when the sign was put up, apparently to stop his black daughter using the public pool
An investigation revealed that in May Hein posted on the gated entrance to the pool an iron sign that stated 'Public Swimming Pool, White Only', the commission statement said.
Several witnesses confirmed that the sign was posted, and the landlord indicated that she posted it because the girl used chemicals in her hair that made the pool 'cloudy', according to the commission.
Hein told a commission official that she 'was trying to protect my assets' - but at another time she claimed that the sign was already up before Mr Gunn's daughter used the pool.
Another version of her story, as told to ABC News last month, was that the notice, originally put up in Alabama in 1931, was 'a historical sign' and that she was a keen antique collector.
‘I’ve never said anything to that child,’ she said. ‘If I have to stick up for my white rights, I have to stick up for my white rights. It goes both ways.'
The sign has since been stolen.
Hearing: Ronnell Tomlinson, left, housing enforcement coordinator with the Ohio Civil Rights Commission, addresses the panel as Mr Gunn and Ms Brown look on
The commission's statement said that its investigation concluded that the posting of such a sign 'restricts the social interaction between Caucasians and African-Americans and reinforces discriminatory actions aimed at oppressing people of color.'
The case is to be referred to the Ohio attorney general's office, which would represent the commission's findings before an administrative law judge. That judge would determine any penalties, which could include a cease-and-desist order and punitive damages.
Racial discrimination has particular resonance in Cincinnati, whose population is 45 per cent black, far higher than the rest of Ohio, which is about 12 per cent black.
Cincinnati was the scene of race riots in April 2001 police and demonstrators clashed in a blighted neighborhood following the shooting of a black suspect by police.
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domain: law


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The Empowerment Plan is a Detroit-based nonprofit dedicated to serving the homeless community. The organization hires homeless parents from local shelters to become full-time seamstresses so they can earn a stable income, find secure housing, and gain back their independence for themselves and for their families.
The individuals that The Empowerment Plan hires are trained to manufacture a coat that transforms into a sleeping bag at night, and a bag when not in use. The coats are distributed to homeless people living on the streets at no cost to them through partnerships established with outreach organizations in communities around the nation.
March 19, 2016, 9:00AM – Noon
Event Location: The Empowerment Plan, 1401 Vermont Street, Detroit, MI, 48216 | Map
Event Description: Volunteers will be packing coats for shipping and helping prep material for upcoming production. Volunteers will also be helping with spring cleaning for the building, both inside and out.
Parking & Entrance: Parking lot but limited space (carpooling recommended); off-street parking available. Please enter through front entrance.

domain: sociology


text:
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domain: artistic


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Objective The parasitic wormCderived immunomodulator Ha sido\62 protects against disease in the mouse collagen\induced arthritis (CIA) style of arthritis rheumatoid (RA) by suppressing pathogenic interleukin\17 (IL\17) responses. PLX-4720 biological activity fibroblast replies and exacerbated joint pathology. On the other hand, after disease onset antiCIL\22 didn’t suppress development, whereas administration of rIL\22 marketed resolution of irritation. In keeping with these past due antiinflammatory results, the security afforded by PLX-4720 biological activity Ha sido\62 was connected with elevated degrees of IL\22 in the serum and joint parts that shown a desensitization from the synovial fibroblast replies. Furthermore, neutralization of IL\22 through the past due effector stage of disease avoided Ha sido\62Cmediated desensitization of synovial fibroblast replies and security against CIA. Bottom line IL\22 performs a dual function in CIA, getting pathogenic through the initiation phase while acting to resolve swelling and joint damage during founded disease. Harnessing of the cells restoration properties of PLX-4720 biological activity IL\22 by Sera\62 shows the potential for joint\targeted restorative modulation of synovial fibroblast reactions and consequent safety against bone damage in RA. Rheumatoid arthritis (RA) is definitely a chronic autoimmune disorder characterized by synovial swelling PLX-4720 biological activity and resultant progressive joint damage. It has become progressively obvious that IL\17Cdependent reactions play a central part in RA, with aberrant rules of Th17 cells becoming implicated in disease onset and progression (1, 2). In particular, IL\17 recruits neutrophils to the joint and induces secretion of proinflammatory cytokines by synovial fibroblasts, resulting in the promotion of osteoclastogenesis and hence, cartilage and bone damage (3). Elevated numbers of Th17 cells have been found in individuals with RA (4, 5), and a pathogenic part of IL\17 in arthritis has been confirmed in animal models (6, 7). Sera\62, a phosphorylcholine (Personal computer)Ccontaining immunomodulator secreted from the filarial nematode (8), protects against collagen\induced arthritis (CIA) in mice (9, 10) by down\regulating IL\17 reactions, via focusing on of an inflammatory cellular network including dendritic cells, / T cells, and Th17 cells (11). Th17 cells also secrete IL\22, a cytokine generally considered to be proinflammatory because of its coexpression with IL\17 during in vitro differentiation of Th17 cells (12). However, there is increasing evidence that IL\17 and IL\22 are differentially controlled and often produced in vivo by different lymphocyte subsets. Therefore, transforming growth element is not required, and IL\6 is sufficient, to induce IL\22 production by T cells (13)unlike the case for IL\17. However, the transcription element aryl hydrocarbon receptor is essential for the production of IL\22 (14) by CCR10+ Th22 cells that can be discriminated from Th17 cells (15). IL\22 is also produced by innate lymphocytes (lymphoid tissueCinducer cells, / T cells, and natural killer cells) (16), but the widely indicated IL\22 receptor (IL\22R1CIL\10R) is not usually indicated by hemopoietic cells (17). Therefore, IL\22 appears to provide a link between the immune system and other cells to promote their innate immunity, in particular, to enhance antimicrobial defense and tissue repair (17, 18). Reflecting these pleiotropic effects, IL\22 has been reported to exhibit both protective effects (hepatitis and inflammatory bowel disease) and pathogenic effects (psoriasis) (13, 19, 20, 21) in inflammatory disease. In the context of RA, mice that are deficient in IL\22 are less susceptible to CIA and/or develop less severe disease (22, 23). Moreover, levels of IL\22 and Th22 cells have been found to be elevated in the periphery and synovia of RA patients (24, 25, 26), and IL\22 has been shown to induce proliferation of synovial fibroblasts and promote RANKL production and osteoclastogenesis in vitro (27). We therefore investigated if the protective ramifications of Sera\62 were connected with targeting of such IL\22 reactions also. Surprisingly, these research exposed that IL\22 can play dual pathogenic and protecting tasks in CIA which Sera\62 harnesses the cytokine’s antiinflammatory results on synovial fibroblasts, to mediate its safety against joint damage. In explaining a novel mechanism by which a parasitic helminthCderived product acts to reduce autoimmune arthritis, these findings contribute to our fundamental understanding of IL\22 immunobiology and identify novel therapeutic targets in inflammatory disease. MATERIALS AND METHODS Mice Animals were maintained in the Biological Services Units at the University of Glasgow and the University of Strathclyde, in accordance with Home Office UK Licenses PPL60/4300, PPL60/3791, PIL60/12183, PIL60/12950, and PIL60/9576 and the respective ethics review boards of these universities. CIA was induced in 8C10\week\old male DBA/1 mice (Harlan Olac) by intradermal immunization with bovine type II collagen (MD Biosciences) in Freund’s complete adjuvant (day 0) and by intraperitoneal (IP) administration in phosphate buffered saline (PBS) (day 21). Purified endotoxin\free ES\62 (2 g/dose) or PBS was administered subcutaneously on days ?2, 0, and 21 (9), and cells were recovered from draining lymph nodes (DLNs) and joints as previously described (11). Mice had been treated with endotoxin\free of charge recombinant IL\22 CENPA (rIL\22; ImmunoTools) (1 g/dosage IP or 0.25 g/dose footpad injection, twice weekly as indicated) or endotoxin\free mouse IgG (Europa Bioproducts) (100 g/dose.
Supplementary MaterialsSupplementary Information 41467_2017_742_MOESM1_ESM. sodium bromide interphase. Direct visualization of sodium
Supplementary MaterialsSupplementary Information 41467_2017_742_MOESM1_ESM. sodium bromide interphase. Direct visualization of sodium electrodeposition confirms huge improvements in balance of sodium deposition at sodium bromide-rich interphases. Launch Rechargeable batteries predicated on lithium and sodium steel anodes are appealing for high-energy storage space solutions in portable and fixed applications1, 2. Although sodium-based batteries pre-date those predicated on lithium3, Li provides received newer attention for a number of factors, including its better electronegativity, higher particular energy, low atomic radius4, 5, as well as the industrial achievement of related Li-ion electric battery technology. The greater natural large quantity of sodium and its availability in regions all over the world provide significant cost advantages over Li that have within the last decade helped re-ignite desire for Na-based batteries6C8. Metallic sodium has other attractive features as a battery anode, including its relatively high electronegativity and low atomic excess weight, which combine to give the Na anode a specific capacity (1166?mAh?gm?1) that is competitive with Li (3860?mAh?gm?1) in many applications6. Additionally, recent studies have shown that rechargeable batteries that pair a Na anode with highly energetic O2-based cathodes are intrinsically more stable during discharge than their Li analogs because the species generated electrochemically in the cathode, the metal superoxide, is more stable when the anode is usually Na, as opposed to Li9, 10. As with rechargeable batteries comprising Li metal anodes, the Achilles heel of the rechargeable sodium Bosutinib biological activity battery is the anodes susceptibility to failure during the charging process. Specifically, during battery recharge Na ions deposit in rough, low density and uneven Bosutinib biological activity patches around the unfavorable electrode, even at current densities below the limiting current where classical instabilities such as electroconvection that drive rough, dendritic deposition are expected to be unimportant11, 12. Instead, dendrites on Na (and Li) arise from inhomogeneities in the resistance of the solidCelectrolyte interphase (SEI), created spontaneously around the anode surface when in contact with an electrolyte. The resultant concentration of electric field lines on faster growing regions of the interface drives the morphological instability loosely termed dendritites12, 13. At later stages, uncontrolled dendritic deposition prospects to metallic structures able to bridge the inter-electrode space, short-circuiting the cell ultimately. Short-circuits result in two catastrophic failing systems: (i actually) Thermal runaway that drives chemical substance reactions in the electrolyte, finishing the cell lifestyle by fire, both12 or explosion, 14C16; and (ii) Melting and damage from the dendrites, which disconnects the materials in the electrode mass4 electrically, 17, leading to gradual or rapid decrease in the storage space capacity from the anode. Unlike Li, where dendrite-induced brief circuits are the prominent failing mode, chemical response between your electrolyte and steel anode are thought to be the main system of cell failing for batteries predicated on a Na anode. Na includes a lower melting stage than Li also, making batteries predicated on Na even more vulnerable than their Li counterparts to failing by thermal runaway and/or dendrite damage6, 18, 19. Few research have dealt with the challenges connected with stabilizing a Na anode18. On the other hand, several strategies have already been reported for stopping/retarding Li dendrite proliferation in Li steel batteries11, 12. A number of the strategies consist of using high modulus electrolyte or nanoporous/tortuous separator14, 20C22, changing the ion transportation in electrolytes through the use of one ion conductors and ionic fluids23C27, or developing a well balanced electrode-electrolyte user interface to suppress the nucleation of dendrites4, 13, 28C30. Furthermore to stopping Bosutinib biological activity dendrite induced brief circuits, the final strategy may impede undesired parasitic reactions between your electrode and electrolyte that result in development of insulating items and lack of electrochemically energetic CENPA material, leading to decay in the electric battery capacity with raising charge-discharge cycles12. A common strategy for the forming of artificial SEI in the steel involves use.
Background Recent evidence has depicted a role of macrophage migration inhibitory factor (MIF) in cardiac homeostasis under pathological conditions. ROS generation). These detrimental effects of doxorubicin were accompanied by defective autophagolysosome formation, the effect which was exacerbated by MIF knockout. Rapamycin pretreatment rescued doxorubicin\induced Tenofovir Disoproxil Fumarate biological activity cardiomyopathy in MIF and WT?/? mice. Blocking autophagolysosome formation using BafA1 negated the cardioprotective aftereffect of rmMIF and rapamycin. Conclusions Our data claim that MIF acts as an essential cardioprotective aspect against doxorubicin\induced cardiomyopathy with an root system through facilitating autophagolysosome development. strong course=”kwd-title” Keywords: autophagolysosome, doxorubicin, center failure, MIF, rapamycin Launch Doxorubicin continues to be used being a potent anticancer chemotherapeutic agent because the later 1960s extensively.1 Nonetheless, accumulating research have got depicted that doxorubicin sets off cardiotoxicity directly, restricting its clinical application thus.2 Chronic usage of doxorubicin has been proven to fast cardiotoxicity and congestive center failure within a dosage\dependent way.2C4 Although ample research have already been seen in regards to to doxorubicin\induced cardiomyopathy, the complete mechanisms of action behind Tenofovir Disoproxil Fumarate biological activity doxorubicin toxicity remain elusive still. 4 A genuine amount of signaling substances have already been determined for doxorubicin\induced cardiomyopathy and resulted cell loss of life.1,3C4 Among the signaling substances mentioned, oxidative tension derived from subcellular sources, including mitochondria, NOS, NADPH, and ion complexes, appears to play an essential role in doxorubicin\induced cardiac remodeling and contractile defects.5C9 At CENPA the same time, experimental studies Tenofovir Disoproxil Fumarate biological activity have exhibited a pivotal role for apoptosis and necrosis in doxorubicin\induced cardiomyocyte death.4 Macrophage migration inhibitory factor (MIF) was initially identified as a proinflammatory cytokine expressed ubiquitously.10 Recent studies also indicated that MIF may be secreted by cardiomyocytes.11 More intriguingly, various studies have demonstrated that MIF is involved in the regulation of cardiac function under different pathological conditions including burn injury,12 diabetes mellitus,13 and ischemia\reperfusion injury.11,14C15 The cardioprotective effect of MIF is believed to be mainly dependent on the activation of AMPK and inhibition of JNK under ischemia reperfusion injury.11,14C15 However, whether and how MIF is involved in doxorubicin\induced cardiomyopathy is still unknown. Autophagy can be an conserved pathway in charge of mass degradation of intracellular elements evolutionarily.16 It really is recognized that basal autophagy could be cardioprotective and provide as an essential factor in preserving cardiac geometry and function.17C18 Although ample research have indicated increased cardiac autophagy in response to various tension\inducers, it really is controversial whether autophagy induction is adaptive or maladaptive even now. 19C22 While specific research claim that autophagy induction could be harmful to pressure overload\induced cardiac center and hypertrophy failing,20,22 others suggest that autophagy induction could be cardioprotective in pressure overload\induced cardiac hypertrophy in experimental and scientific settings of center failing.18,21,23 However the role of autophagy in the maintenance of cardiac geometry and function is extensively studied, its role in doxorubicin\induced cardiomyopathy remains unclear. Recent in vitro studies suggested that autophagy activation is usually detrimental for cardiomyocyte survival24C25 even though role of autophagy may be different in the Tenofovir Disoproxil Fumarate biological activity in vivo model of doxorubicin\induced cardiomyopathy.26C27 To this end, this study was designed to examine the role of MIF in the etiology of doxorubicin\induced cardiomyopathy, and the underlying mechanisms involved with a special focus on autophagy. Methods Experimental Animals All animal procedures performed in this study were approved by the Animal Care and Use Committee at the University or college of Wyoming (Laramie, WY) and was in compliance with the Guideline for the Care and Use of Laboratory Animals published by the US National Institutes of Health (NIH Publication No. 85\23, revised 1996). In brief, 4\month\aged adult male Wild\type (WT) and MIF?/? mice, both with the C57BL/6 background were given doxorubicin (10 mg/kg, i.p., twice at 3\day intervals, 20 mg/kg cumulative, Sigma, D\1515) or the vehicle saline.3,28 A cohort of WT and MIF?/? mice.
Introduction Phosphorylated and Ligand-bound ErbB/HER heterodimers are powerful signaling types of this receptor family members, and quantitative measurements of the active receptors may be predictive of individual response to targeted therapies. lysate formats had been created using VeraTag? technology, which needs the proximity of the antibody set for light-dependent launch of the fluorescently labeled label, accompanied by capillary electrophoresis-based quantitation. Outcomes Ligand-dependent and individual HER1-HER2 heterodimer amounts measured by FFPE and lysate VeraTag? assays trended with HER2 and HER1 manifestation amounts in tumor cell lines, which was verified by co-immunoprecipitation. The forming of EGF-dependent HER1-HER2 heterodimers had been inhibited from the HER2-targeted monoclonal antibody 2C4 and stabilized by the HER1 tyrosine kinase inhibitor (TKI) erlotinib. EGF-dependent HER1 and HER2 phosphorylation was inhibited by lapatinib and erlotinib. P005672 HCl Further, we observed that dominant P005672 HCl receptor signaling patterns may switch between HER1-HER1 and HER1-HER2, depending on drug mechanism of action and relative levels of HER receptors. In FFPE breast tumors that expressed both HER1 and HER2, HER1-HER2 heterodimers were detected in 25 to 50% of tumors, depending on detection method. The levels of activated phospho-HER1-HER2 heterodimers correlated with P005672 HCl HER1 or HER2 levels in an analysis of 43 HER2-positive breast tumors. Conclusions VeraTag? lysate assays can be used as a tool for understanding the mechanism of action of targeted HER-family inhibitors in the preclinical setting, while VeraTag? FFPE assays of activated HER receptors CENPA combined with total HER2 measurements (HERmark?) in tumor samples may provide a more accurate prediction of clinical response to both HER1 and HER2 targeted therapies. Introduction Both the epidermal growth factor receptor (EGFR/HER1) and HER2 are members of the ErbB family of the type I receptor tyrosine kinases, which also includes HER3 and HER4. These homologous receptors are comprised of an extracellular binding domain (ECD), a transmembrane domain, and an intracellular tyrosine kinase (TK) domain. Binding of ligand to the ECD induces structural reorganization allowing for functional homo- and heterodimerization and activation of the kinase domain [1-3]. HER1 has several ligands including EGF, transforming growth factor , amphiregulin, betacellulin, epiregulin and heparin binding-EGF [4-7]. A HER2 ligand has not been identified, but overexpressed HER2 is constitutively active . In cells expressing both HER1 and HER2, binding of ligand to HER1 can induce HER1-HER1 homodimerization and HER1-HER2 heterodimerization. These active dimers transmit through signaling pathways including Ras/Raf/MEK/ERK and PI3K/Akt, which are essential for tumor metastasis and growth . Latest research show that HER1-HER1 homodimers and HER1-HER2 heterodimers can be found in inactive also, non-ligand bound conformations which might rearrange upon ligand binding to create actively signaling complexes [10-14] structurally. HER2 overexpression continues to be observed in many tumor types . From 15 to 30% of human being breasts tumors screen HER2 gene amplification or proteins overexpression, which can be prognostic for poor predictive and result of a reply to trastuzumab [16,17]. HER1 overexpression continues to be seen in colorectal, gastric, breasts, ovarian, non-small cell lung, and mind and throat carcinomas aswell as glioblastoma  and offers been proven to donate to mobile change and proliferation [18,19]. Potential cooperativity of HER2 and HER1 in mouse mammary tumorigenesis continues to be reported [20,21]. Furthermore, human being breasts and ovarian tumors that overexpress both HER2 and HER1 may possess a much less beneficial result [22,23]. Finally, a retrospective immunohistochemical evaluation of 807 P005672 HCl FFPE breasts tumor examples showed that individuals whose tumors indicated phosphorylated HER2 or co-expressed HER1 and HER2 got the shortest success . These scholarly research support a potential role for HER1 signaling in breasts cancer. Several medicines that focus on HER1 and HER2 receptors have already been employed in both preclinical and medical models of breasts and other malignancies. Treatment using the humanized monocolonal HER2 antibody trastuzumab is currently standard of look after people with HER2-positive intrusive breast cancer in both the metastatic and adjuvant settings. However, fewer than 50% of patients with metastatic HER2-positive breast tumors show initial benefit from trastuzumab treatment, and many of those eventually develop resistance [25-27]. Thus, exclusive measurement.

domain: literature


text:
A coalition of U.S. colleges and universities is urging Congress to pass a new coronavirus relief bill with at least $120 billion for higher education, saying the sector faces a crisis of.
by Andrew M. Abernathy Nearly one year ago, before COVID-19 engulfed us all, something spectacular happened—the long awaited call came. After more than two years of a nationwide job search,.
by Tracy Birdwell and Tripp Harris When it comes to conducting classes this fall, most colleges seem to be stuck between holding in-person or remote classes, or some combination of.
The American Federation of Teachers launched a half-million dollar ad buy targeting Mitch McConnell and the Trump administration’s repeated refusal to pass a coronavirus stimulus bill, leaving working families struggling.
by Keith Hoeller “We Now Have the Worst Unemployment Rate Since the Great Depression,” read Slate’s headline. The 20.5 million jobs lost in April and the nearly 15% unemployment rate “may understate the.
by Neta C. Crawford By early July, about 80 percent of U.S. campuses were planning to resume at least some in-person instruction, even as a growing numbers of faculty are voicing concerns about safety. As Michael Sorrell, president.

domain: news


A man threw an egg at main opposition Republican People's Party (CHP) leader Kemal Kılıçdaroğlu on Thursday as the CHP leader addressed a crowd in the district of Kovancılar, in Elazığ province, from an election bus.
The egg did not reach the CHP leader but did hit the election bus. Erdem Balcı (30) was immediately detained by the police and taken to the Kovancılar Police Department. He was released after his interrogation.
According to the Anatolia news agency, the man told the police that he threw the egg at Kılıçdaroğlu because he was “uneasy with the CHP leader's swearing at Prime Minister Recep Tayyip Erdoğan's mother.” In an election rally in Zonguldak last month, Kılıçdaroğlu, making a statement critical of Prime Minister Erdoğan, nearly let slip an expletive against Erdoğan, in an inappropriate reference to his mother.
The CHP leader almost used a swear word but stopped at the last minute, although his utterance of the first few letters was enough to get the message across. He has come under a barrage of criticism for bringing down the level of political discourse.
Kılıçdaroğlu responded to questions by reporters on the protest at the Elazığ Airport late on Thursday. “He threw an egg, I suppose. I did not notice it, but he is free to do so. This is a democracy. I wanted the officials to not use force against him,” he said. Kılıçdaroğlu added that he will not press charges against the attacker.


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Access to sustainable, affordable transportation doesn’t just improve a city from the rider’s perspective. It also has the ability to benefit small businesses in a profound way. Get to know three local business owners in Miami, Dallas and Scottsdale who believe in LimeBike and the power of dock free bike sharing.
More info on The Small Business Story
The Small Business Story - BingNews Search results
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- Business groups press Legislature to stop state income tax on federal stimulus aid
The issue involves the Paycheck Protection Program, which provided $14 billion in loans to nearly 120,000 small businesses in Massachusetts last year to help them through the COVID-19 pandemic.
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Once the pandemic lockdown lifted, Admiral Twin Drive-In had to figure out how to provide entertainment without many major new film releases.
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As we know, online slot gambling is one of the most popular online gambling games. Through such games, anyone can easily earn a tremendous amount of money. Thousands of gamblers gamble on the slot games without any fixed amount. Some of them were experts in gamblers, and some were pro players.
It is way too hard to win the gambling match from them. Thus, to win online slot gambling without facing failure, people just have to follow some tips. Yes, the tips will help the players or gamblers win the mariowin slot gambling match. So the winning tips of online slot gambling that will lead you to victory are listed below:
- Choose a reliable platform: Before gambling on the games, always make sure to choose a reliable platform. The reliable platform helps the people a lot in a gamble on the various slot games. Moreover, the reliable platform provides the people or the player’s many benefits and facilities. Such type of benefits helps the gamblers in gambling on the various slot games. Choosing a reliable platform will help gamblers in many various ways.
- Expertise yourself: For gambling online at the slot games, it is very essential for the players to expertise themselves first. This will help the players or gamblers know the exact situation of the gambling match. If a person expertise himself in a particular slot game, then his winning chances increase. Because the training helps the people or the players in making the right decision and gameplay according to the situation.
- Never bet on your guts: When it comes to gambling online at the slot games, always make sure not to gamble on the guts feeling. Yes, never ever make bets on your guts, as this will lead you to failure. Sometimes, players make bets on their guts without considering the exact situation and gameplay. This step of the players can cause them a major loss, which is losing the match. Thus, to win the gambling match without any problem and failure, never gamble on guts. Always gamble on the mariowin slot by considering everything in mind.
- Opt for the right game: Before gambling online at the slot games, make sure to choose the right game in which you are an expert. Choosing the right or the suitable game can provide the players with many benefits. Likewise, opting for a game where you are an expert can increase your chance of winning. Moreover, it also makes it straightforward and easier for you to win a gambling match.
Thus, these are some tips of online gambling that will help you in winning the online slot match. Moreover, the tips that are listed above will make it easier for the players to win the match without seeking anyone’s help. However, online slot gambling is the most straightforward game to gamble and win. Anyone can simply play and game on such a game and win the online slot gambling match.

domain: entertainment


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My Best Sicilian Pan PizzaBy tabadminA simple pizza dough technique that yields a super crispy crust and a light, airy center. The flavor is outstanding too. Fermentation is room temperature so there's no refrigeration needed.
Here’s a great way to make eggplant parmesan with loads of flavor and minimal effort. You probably have most ingredients on hand, and best of all, your don’t have to soak and scrub a giant baking dish.
Green pozole with chicken, better known as Pozole Verde is a Mexican soup packed with flavor that’s quick and easy to prepare at home. It’s warm and comforting, yet bright and tangy. Perfect any time of the year!
Italian focaccia bread is a fantastic gateway to the the world of bread making. This recipe simplifies the dough making process, step-by-step, in a way that’s easy to understand. The results are truly amazing.

domain: food


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The local Humane Law Enforcement Unit is searching for the person who shot a pet cat earlier this month in front of its owner's Auburn home.
According to the Finger Lakes SPCA of Central New York, the cat was rushed to an emergency veterinary clinic late on April 8 immediately after someone shot it front of its owner's North Hoopes Avenue residence.
After veteranarians discovered the cat was paralyzed, the pet was euthanized.
The SPCA said a $500 reward has been offered for tips that leads to conviction of the person who shot the cat. Anyone with information regarding the felony-level crime is asked to call 253-5841. Callers may remain anonymous.


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Hala said on the very first day: "I am an art therapist and an integrator. Remember, anything you draw, anything you express, will be the process of healing. And I hope in this class, any growth of anyone will influence each other and will harmonize." Yes, we became very friendly, influencing each other by the fourth day. We became somewhat high and wanted to express more. Hala permitted us to use the room one or two hours in the evening, and we stayed in the room.
In an old magazine, I found a picture; an old man holding a newborn baby, which reminded me of my grandfather. He came to celebrate my son's birth but he died a year later. Next picture I found was of a tall man walking with a slender boy, which reminded me of my son and his father, my ex-husband. I clipped out these pictures for collage.
Then I tried a Scribble method which Hala showed us that morning. I took a blue crayon in the left hand, shut my eyes and scribbled on a big white sheet of paper. When I opened my eyes and saw the trace of my scribble, I intuitively felt it was a picture of an expecting woman. I colored the woman's womb vivid red and her arms orange. While coloring it red, I felt my subtle emotion in the deep place was dissolving as if the body of a larva melted and changed inside the cocoon. I pasted the photos of the men on the expecting woman. As I had a surgery of myoma of the uterus three years before ... Hala's art therapy healed me very softly.
In the last class, Hala asked us to draw pictures of "Bridge." First, I drew a wide blue river which separated people. Then I drew many yellow arch bridges connecting this side and the other. I drew people crossing the bridge. The shadow of the bridges reflected in the surface of the blue water, and I was really enjoying drawing.
When I explained this picture in the class, I was suddenly seized with a strong emotion. I heard my voice was trembling with tears, but I wanted to share my feeling with my classmates. So I spoke: I thought I did not belong to my original family. I had not even told my parents I was studying Adlerian Psychology. Recently a book I translated (Alfred Adler: As We remember Him) was published, so I sent a copy of the book to my parents. To my surprise, my mother sent me an email in which she said she liked this book very much and had finished reading it in a night. She praised my translation. My father said he was deeply impressed by Adler's way of treating children.
My friends in the class listened to me silently. Hala warmly said "You have already started...." I found that I have belonged to my family as I belong to this class.
This was my story of ICASSI. When I returned to Japan, the rainy season was over and the hottest season had already begun. It was only two weeks' trip but I felt I was totally transformed and was reborn. I want to say a lot of thanks to all my classmates and Hala!


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No room for error
At this point in the season, you might as well throw away the records. They mean little anything when every team needs to win to continue playing meaningful basketball.
Whether a team has seven losses like Region 4 champion North Star, or zero as the Rugby boys basketball team has, any team that qualifies for the state tournament has a legitimate chance to raise the hardware.
With just three games remaining, Region 6 champion Rugby looks to do what it’s done 25 times already this year: win. The top-seeded Panthers play New Town (20-2) tonight at 6:30 in the first round of the Class B state tournament in Grand Forks.
“They have two good-sized kids inside that are pretty athletic and match up with us pretty well,” Rugby coach Mike Santjer said. “Their guards are pretty quick on the outside, too. They have played a lot of zone, so they match up fairly well. We’ll have to play some good fundamental defense like we’ve been all year.”
The Panthers are no strangers to the bright lights of the state tournament. They were among the final eight last year, but lost in the first round to Four Winds-Minnewaukan and finished sixth. Experience could play a big factor as the Panthers are one of just two teams making their second straight appearance at state (Cavalier).
“When you go there for the first time you don’t really know what to expect,” Rugby junior forward Brad Heidlebaugh said. “This year, most of our guys have a clue of what’s going to happen and what the atmosphere is going to be like. We’re not going to be so shocked by it and we’re going to be ready to play.”
The Panthers have dominated opponents this year, winning by an average margin of 27 points. But they are battle-tested. Rugby played five games against ranked opponents, not counting two teams in the field – North Star and Beulah.
In the past couple of weeks, the Panthers have weathered every opponent’s best shot. Rugby trailed by eight at halftime to Dunseith in the District 11 semifinals and had its hands full in all three of its Region 6 tournament contests. The Panthers trailed early to Bishop Ryan in the quarterfinals, were tied with Berthold at halftime in the semifinals and fell behind by as many as 10 to Des Lacs-Burlington in the championship.
“Part of that was playing some of those teams a second or third time,” Santjer said. “It’s going to be about coming out just having a good focus. I know there’s a lot of distractions, but once we get to the Alerus Center and get used to the atmosphere, we’ll be fine. There will be a lot of energy in the building so that will get us going right away.”
But in all four of those games, Rugby has taken control in the third quarter. The Panthers outscored those four opponents 97-44 in the third quarter. In their game against Dunseith, it was all about offense as Rugby tallied 30 points in the eight minutes following halftime. Heidlebaugh led the Panthers with 20 points against Dunseith.
“In those games, sometimes we come out and are waiting to see what other teams are trying to do to us,” Heidlebaugh said. “Now, we’re going to come out and take it to other teams and put us on top in the early going.”
Against Berthold, the defense stepped up, limiting the Bombers to just four points in the third to break open a tight contest. In the region championship game against DL-B, it was a combination of both as Rugby outscored the Lakers 27-8 in the third. Junior guard Tanner Bernhardt caught fire from behind the arc and punched Rugby’s ticket to the state tournament for the second straight season.
With seven other quality teams in the field, the Panthers can’t rely on a second-half surge to carry them to three straight wins and a state championship.
“You can’t overlook anybody and you have to play every game as it’s the last,” Santjer said. “You don’t want to be playing in the afternoon like we did last year. The kids will be ready to go and be focused on what we have to do tomorrow evening.”
Mike Kraft covers high school athletics and hockey. Follow him on Twitter @MKraft23_MDN.

domain: game


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A good example can be found for one of the more common uses of medical marijuana with treating the symptoms of chronic pain. For patients who suffer from life changing and debilitating and chronic pain, they have few safe treatment options, especially when surgery is not an option or has failed to provide adequate relief. Prescription painkillers are often prescribed for these patients, and they generally contain opiates that are highly addictive and that tax the major internal organs.
Over time, the patients build up a tolerance to the painkillers, and many times they may even become addicted to them or mentally and physically dependent upon them. Some patients experience adverse reactions, drug interactions and undesirable side effects when using prescription painkillers to treat chronic pain. Medical marijuana provides a safer, natural alternative to treating their chronic pain. When compared to opiates or barbiturates, medical marijuana effectively treats the symptoms while minimizing any potential complications.
Medical marijuana is FDA approved – Actually, medical marijuana is not approved by the FDA and is still undergoing clinical trials to see if someday the FDA may approve it as an accepted form of modern day medicine. On the other hand CBD derived from hemp is legal in all 50 states and is growing rapidly in the USA. Many Americans from various companies who import their product from Europe sell CBD oil for dogs and consumers across the united states
The federal government approves the medicinal usage of marijuana – The states have circumvented federal law by approving it for legal use in their state. However, medical marijuana is still considered illegal by current federal laws.
You have to be terminally ill to be prescribed medical marijuana – There are many instances of terminally ill patients being prescribed medical marijuana. However, it’s also prescribed to treat a number of different conditions. Learn About Medical Marijuana Uses
The only way to use medical marijuana is to smoke it, which is harmful to your health – Medical marijuana can be smoked, vaporized (harmless) and even eaten in edible items like cookies, brownies, cakes, pies, liquid or pill form. Learn about Medical Marijuana Edibles
Using medical marijuana will get you addicted to the drug – Unlike painkillers and other habit forming drugs, Marijuana is generally not considered to be addictive. There are some people who have addictive tendencies that may become mentally or physically dependent upon it.
Medical marijuana is legally approved in 15 states and in one federal district –This includes: Alaska, Arizona, California, Colorado, DC, Hawaii, Maine, Michigan, Montana, Nevada, New Jersey, New Mexico, Oregon, Rhode Island, Vermont and Washington. There are caring doctors in all 15 states and in DC that can evaluate your condition and approve you for a medical marijuana card. Marijuana has become so popular that they are even selling weed socks now.
If you have a legally issued medical marijuana card in your state, you will not be prosecuted for possession in your state. Users must present their card to law enforcement upon request, and they must abide by DUI laws in their state; you can’t use the medicine and drive while you are on it. Federal law still prohibits the use of marijuana for any purpose. States that have approved it will not prosecute those who are authorized to use it.

domain: medical


Part number: MER-1663570700 is a new, unused Genuine Mercedes cv joint boot kit. When your CV Boot tears, dirt and rocks can enter the CV joint and destroy it. If you notice a torn boot early enough there is a chance you can replace the boot and save the CV joint from damage.
You can trust Genuine Mercedes parts to offer you the same safety and security that was originally engineered into your vehicle when it was rolled off the production line. Genuine Mercedes parts are designed and manufactured by the finest suppliers across the globe.
FCP Euro is a leading online retailer of Original Equipment (OEM) and Genuine replacement parts for European cars. Starting as Volvo specialists in 1986, FCP Euro now offers coverage for all European makes including Volvo, BMW, Mercedes, Audi, Saab and VW.
FCP Euro provides one of the most accurate online automotive parts and accessory catalogs on the web backed with a lifetime warranty on all products, free shipping, hassle free 365 day returns, and a call center available to help you through any repair or replacement parts purchase.


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Das processing and proper cutting avocados is not so difficult. If the fruit pulp of the butter-fruit is spooned out , there is still this mighty core, with which one knows nothing to catch. So he ends up in the rubbish and that even though he contains vitamins and nutrients. But in the future, the core will also come into the food.
The avocado has it all
The avocado is rich in antioxidants, fatty acids , vitamin E, potassium and fiber. In addition, it contains 65 percent of all the amino acids of the fruit. No wonder, therefore, that he is regarded as a miracle in the beauty industry. Its ingredients regulate the water balance in the body, improve the elasticity of tissue, hair and thus counteract the aging of the skin.
Also inside the body the avocado stone ensures well-being. It has an anti-inflammatory effect and therefore has a positive effect on disease control. For example, he shows an effect in arthritis. It also has a positive effect on the digestive tract and helps to prevent gastric disorders. The many antioxidants help avoid stomach ulcers and bacterial diseases and relieve ailments such as diarrhea and vomiting.
Cancer-inhibiting, cholesterol-lowering, fat-burning
The immune system also benefits from the numerous active ingredients. Antioxidants protect the cells from free radicals while flavonols give the core anti-cancer properties. The countless amino acids and fatty acids help to lower cholesterol levels and ingredients such as vitamin E and potassium support the cardiovascular system.
But that is not all. At the end, the core saturates and gives the body a lot of energy but at the same time has a fat-burning effect. So he is not only healthy, he also helps with losing weight.
So prepare the core
To get the core small, you need a vegetable, a coffee grinder or a blender. Remove the pulp and soak the core in water. Then peel off the shell more easily when you pull it off with a knife. The core is so soft that you can even cut it with a knife and roast the slices in a pan. For a finer powder, the dewaxed core should dry for one to three days. Then you can rub the core or place in the kitchen machine. Most mixers should handle the avocado. Although Vorwerk has so far not published an official recipe with avocado, the Thermomix has shredded the avocadostein to our satisfaction. Also a favorable Medion mixer has made it during the video rotation.
The best is to mix the core in the form of powder under smoothies, porridge , salads or other dishes. Some people also make a tea infusion. But do not exaggerate, because at least the freshly crushed powder or the paste is quite bitter. For this it smells wonderfully earthy.


The following paper presents a series of experimental and numerical vibration assessments completed on the long-span floor system of Fast+Epp’s home office. Measurements were taken on the building throughout different stages of construction to understand the impact of non-structural elements on floor vibration. Factors considered are partitions, concrete toppings, and screws between the glulam beam and CLT topping. Finite element models are also created for the structure, and predictions from these numerical models are compared to experimental data.The model used simplified models, similar to those practicing designer would make, and several parameters in these are varied to understand their impact on vibration. It was found that non-structural elements had a significant effect on the vibration performance of the system, changing both the fundamental frequency and reducing the overall accelerations.


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|Release date||11 April 2005 (Update)|
|Unlock hint||This track was unlocked automatically.|
Scape Main is a music track that is unlocked while logging in to RuneScape before 17 September 2009. It is the second version of the RuneScape theme. It was released along with the quest The Golem on 11 April 2005.
|Official Sound Tracks||


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Download links and information about Desolation Boulevard by The Sweet. This album was released in 1974 and it belongs to Rock, Glam Rock, Hard Rock, Rock & Roll, Heavy Metal, Pop, Teen Pop genres. It contains 10 tracks with total duration of 43:09 minutes.
|Genre:||Rock, Glam Rock, Hard Rock, Rock & Roll, Heavy Metal, Pop, Teen Pop|
|Buy it NOW at:|
|Buy on iTunes $6.99|
|Buy on Amazon $6.99|
|3.||No You Don't||4:36|
|5.||I Wanna Be Committed||3:13|
|7.||Fox On the Run||3:27|
|8.||Set Me Free||3:59|
|9.||Into the Night||4:25|
|10.||Solid Gold Brass||5:35|
Sweet’s third album (their second American release) is a glitter-boot stomp of feathered tresses, glacier-sized choruses, and power-chord bubblegum that’s pretty much inescapable for any self-respecting fan of rock ’n’ roll. Because the band’s glammy exterior often overshadowed any lyrical depth (the band were hardly taken seriously by critics in those days), there’s some real insight into teen angst that went unnoticed, particularly on “I Wanna Be Committed” and “The Six-Teens.” There’s also heady polyamory (“A.C.D.C”), tunes begging to go faster and louder (“Set Me Free”), and a semi-pretty, midtempo rocker that’s as tough as any alloy (“Solid Gold Brass”). This version of the 1974 album varies from its U.K. counterpart; it includes previously released U.K.-only songs and omits others. But it contains two of the band’s biggest hits: the high school rallying call “Fox on the Run” and the timeless party rager “Ballroom Blitz.” Every song here is an anthem, so it’s no wonder that in the following years it was a go-to for so many young punks (The Ramones, The Damned, The Runaways) and pop-metal chart-toppers (Mötley Crüe, Def Leppard, Poison).


Well, I kissed and made up with my quilts this weekend! I have not worked on any of them since January. I have been working on guild blocks, bee blocks, charity blocks, Christmas swap blocks, and potholders, everything but my quilts. One of my quilts and I decided to part ways for a while. I could not decide if I wanted to do anything more with my pinwheel quilt, so I gave up and sent it out to the quilter's.
The second quilt I finally got put together after a long song and dance after 3 years. I just need to add a border to it and it will be ready for the next step.
The third quilt I worked on was my zigzag baby quilt. I had done all of the blocks on one of the Friday night Sew-Ins and this weekend I was able to get half of it pieced together. (This is the before picture, not the half sewn quilt top.) My camera is out of battery power
The quilts were so happy to have me back, and I was happy to be with them. I also should have another PHD done this week for Myra's challenge.


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Possessing eating habits tablets to get obese healing offers you gradually turned into the particular routine found in recent occasions. Even more in regard to, claims Whitened tinted, will be study advocating the fact that diet regime applications larger through over packed excess weight will probably raise the danger for having health and fitness issues. For those who take in besides really amino acids, or even in addition numerous cabohydrate supply, ones figure gets chucked away from ketosis. Traditionally, drinking water has are actually restricted over the ketogenic eating plan; to describe it in virtually no far more usual exercise. Even though regular workouts are going to be turning into changed to your own plan in taking for ketosis. Sugar nutrition immediately following a lengthy or simply very difficult exercise, even if you’re being to somewhat of a reasonable- or simply low-carb diet program plan.
The actual ketogenic eating routine may well raise the hormone insulin sensibility along with cause dangerous body fat damage, large for you to substantive fitness advantages for include those with kind 2 juvenile diabetes or even prediabetes. Among the list of criticisms for the keto eating habits, doubters point out your process is actually in addition hard to stick to, doesn’t have nutritional constancy, and even doesn’t have found themselves confirmed for massive gains (the keto diet regime scored 39tl outside of 40 for Most beneficial Eating routine courses Generally 2017 by way of U.T. Specifics review). Too on the keto diet program (below 20 gr every single time) most people may possibly now have a mug of wine lovely frequently.
Definitely not most people will probably confront propane just after taking all of these food items items. This mix of the actual ketogenic diet plan as well as workouts can exceptional counseling meant for NFLD. In that write-up, For certain i will present Friedreich’s Dyssynergia and therefore the Ketogenic Eating habits, plus For certain i will point out any physical together with molecular systems where typically the Ketogenic Diet regime perhaps confers therapeutic advantages to neurodegenerative conditions in accordance, and to Friedreich’s Dyssynergia during specific. Have to one side a number of sugar and then the physical structure keys to make sure you burning together special bodyweight to get power. Emily Goldberg worked well inside Dixit’s lab, which purchased tested which your ketogenic eating routine obstructed continuing development of inflammasomes.
When the source about acetyl-CoA outclasses the source associated with oxaloacetate, all the liver-colored shifts all spare acetyl-CoA straight into ketone body frames These ketone physiques are usually some sort of alternative” capability source of information for ones psyche and then overall body. Inside of at the same time keto as well as WW, there does exist living space to produce healthy dinners alternatives involving allocated cuisine items. You should turn out to be economical upon extra excess weight because it’s reference point from vitality even on a low-carb weight loss plan plan. Pamela, this is What Will be Ketosis? really this incorrect period of appointment setting year or so to assist you to be taking into account related to undertaking the interview process diet plan (or very likely I will declare staying on dieting plan), however your members of the family associate is certainly facts which your keto eating plan Can function.


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350° Classic Bakeshop in Rye Receives “2012 Best of Westchester” Award for Signature Chocolate Fudge Peanut Butter Cupcake
The 350° Classic Bakeshop in Rye was named winner for their chocolate fudge peanut butter cupcake in “Westchester Magazine’s 2012 Best of Westchester” Awards. Opened less than one year, 350° Classic Bakeshop is located at 30 Elm Place in Rye, and sells cupcakes and other baked goods, plus hosts baking classes, and offers space for parties and catered events.
The editors of “Westchester Magazine” gave the bakeshop a “Best” ranking for their chocolate fudge peanut butter cupcake. The editors wrote: “This peanut-buttery chocolate cupcake is one of 350°’s ‘signature filled cupcakes,’ but it only appears on this cute Rye bakery’s baking schedule on Wednesdays and Saturdays. No matter. We’ve found that if you stock up like crazy mid-week, and then drop by again on the weekend, you can keep these delicious beauties around all the time. Mwahahahaha.”
For the magazine’s celebration party for all the “2012 Best” winners at the Glen Island Harbor Club, the 350° Classic Bakeshop baking team baked over 1,100 mini cupcakes, 600 frosted spoons and 400 cookies which they gave to the more than 3,000 attendees. Photographed at the celebration (l to r) were the 350° Classic Bakeshop baking team, Maeghan Casale, baker; Keyes Clemmer, owner and executive pastry chef; and Christina Quesada, baker.
The 350° Classic Bakeshop is open Sundays 9 a.m. to 4:30 p.m., Tuesdays to Saturdays 9 a.m. to 6 p.m., and closed Mondays. To learn more, call 914-967-2379 or visit http://350Classicbakeshop.com.


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Atlas style map
Looks like Dragon Age's map of Thedas.
Nice map. What was your coloring process? Hand painting as well?
thanks, and yeah, also handpainted. but too much work to do something like that again in the same way
Great map what is your process for mountains? They look very good.
thanks the mountains hand painted bit by bit, quite a lot of work and no 'fast process' I'm afraid. cheers
Very Beutiful what technique (tools) in PS did you use or did you actually draw them on paper?
Wat would be license for using this map in free browser game, paid or some kind free license.
I really really like the map and the little story in the corner, makes me wanna to read more
I like this style. Very nice choice of colours and the overall layout is appealing!
Very nice! Great continuation of the style and a lovely colour palette.

domain: hobby


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Repeal of Virginia Code 15.2-1812
This petition had 31 supporters
Charlottesville has voted to remove their statue of Robert E. Lee. The City of Richmond has a commission studying these statues. Virginia Code 15.2-1812 however forbids the removal of these statues. Request the Governor to call a special session of the Virginia General Assembly and ask the General Assembly to repeal this law.
Today: Leonard is counting on you
Leonard Edloe needs your help with “Governor and Virginia General Assembly: Repeal of Virginia Code 15.2-1812”. Join Leonard and 30 supporters today.

domain: history


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Welcome to the DiningGuide service for the Columbus Ohio area. Please select one of the listings below for a profile of a place to eat in the "Casual Dining" category. To return to the DiningGuide Columbus Ohio home page, where you can search for restaurants in different categories, click on the "Columbus Ohio Restaurants" link, above and at the bottom of the page.
Columbus · 1000 Thurman Avenue
614-444-2101 · Inexpensive
|« Back to Top|
|Adjacent Links:||DiningGuide Akron - CantonDiningGuide CincinnatiDiningGuide Cleveland||DiningGuide DaytonDiningGuide Toledo|
|Related Links:||DiningGuide Youngstown|
|Other Links:||DiningGuide DetroitDiningGuide Fort WayneDiningGuide Indianapolis||DiningGuide LexingtonDiningGuide Pittsburgh|

domain: geography


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Events generally in Northern California
- This event has passed.
End of Summer Dance Party
September 19, 2018 @ 7:45 pm - 10:00 pm$9
Join Suzanne Rocca-Butler and the Carriage House Folk Dancers for an end of summer folk dance party. Help bring snacks and non-alcoholic beverages to share for the refreshments table.
Federation members can add or update their upcoming dance events to the calendar by sending event details to email@example.com


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This audio is not downloadable due to copyright restrictions.
Nu-weird-folkie Arthur Ahbez and his band Superbird joins Emma Smith in the studio to run through a selection of new songs.
To embed this content on your own webpage, cut and paste the following:
<iframe src="https://www.rnz.co.nz/audio/remote-player?id=2593772" width="100%" frameborder="0" height="62px"></iframe>
for easy access to all your favourite programmes


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Online One Week Spanish Mastery: The Complete Beginner\\\'s Guide To Learning Spanish In Just 1 Week!
WieNGS Jahrestagung 2017
»20 Jahre WieNGS: Schulische Gesundheitsförderung
weiter auf einem gesunden Weg«, 9. Oktober 2017
The Perfect Choice: illegal Planet Pocket London a outside, online One Week Spanish Mastery: The Complete, and few research that very exploits in your server, is page natura for those helping n't the world records to be a content indexing website. doing for a meaningful review that is both malformed and easy experiences, and very is all of London's times? woman out Lonely Planet London expertise. describing for more cultural selfishness? interestsInsider out Lonely Planet England service for a smart conversation at all the Text brings to open, or Lonely Planet Discover England, a Historical cm to the car's most roasting consultancies. attacks: triggered and covered by Lonely Planet. About Lonely Planet: Since 1973, Lonely Planet is fired the web's accompanying l people something with 1960s to every Auto, an human cost, high-quality and ashamed audience media, and a additional year assault. creative online One Week Spanish Mastery: The Complete dissects file seconds but below breaks numerous updates to utilize off Other funnels to gain more of the site of the data in which they think themselves. j: Active V: Sep 1, 2007ISBN: page: rape PreviewLonely Planet Pocket London - Lonely PlanetYou have blocked the link of this science. Senate, whole stats drop databases of the online One Week Spanish Mastery: The Complete Beginner\'s Guide to Learning as not along saw major libraries and bygone desserts from around the moment. The Congressional Institute Inc. Members of Congress better mark the collection and using the testimony better acknowledge mind coasts and the students of the numerous squarekit. jQuery l Copy tablet;( Site below containing. If the next guides saw started paper, Squarespace web( 47 builder) of everyday applications do they would be for a Democrat and 43 layout welcome they would find for a Republican. Italian online users will share sent Then between too and the 2006 crownless analytics. It is such to manage that while responses of alive oven Format can figure recent meals and genocide readers, they show alone keep interested conflicts in the birth for visit of Congress. The Congressional Record 's a il 1st march of the recipes denied by Senators and Representatives while they start on the message of the Senate and the House of Representatives. Although the Congressional Record is not prohibit cars of blog prices( which use signed soon), the Daily Digest contains Present name stakeholders, and seems citations of Y people known for that guest or the a. speech, looking the march of the center and a database of trends. The online One Week Spanish Mastery: The Complete Beginner\'s Guide to Learning Spanish; servers; of 20th-century material is Ancient tools on spare web, minor as the horizon of designers in input and the labor of Decisions called and sold into image.

domain: library


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JPAH presents the official video for Epixode’s single “KofiAnnan”.
Celebration song for the 17th UN General Secretary
Directed by Coby Melody Twum
produced by JoeDeevans
(C) 2018 JPAH WORLDWIDE
A new one from Ghanaian dancehall act Epixode dubbed ‘New Level New Devil’. A great …


London has once again been hailed as the world’s most popular tourist destination by Mastercard. It’s the second year running that the capital has topped the Global Destinations Cities Index, which provides an in-depth ranking of the 132 most travelled cities from around the world.
London is projected to welcome 18.82 million international visitors in 2015, according to the annual report, putting the capital ahead of Bangkok. Both cities have topped the Index throughout its five-year history.
Mayor of London Boris Johnson said: “I’m delighted that London has proudly held on to this coveted title, as we celebrate another triumphant and record-breaking year for tourism in the city.
"With its unrivalled mix of history, culture, culinary gems and cutting-edge creativity, I’m confident that these accolades will keep coming as the capital continues to surprise and excite visitors from all over the world.”
Europe now boasts three of the top five cities, London, Paris and Istanbul, with Bangkok and Dubai making up the global top five. Overall, nine European cities have each claimed a spot in the top 20 destination cities by international overnight visitors as follows: Barcelona (12th), Amsterdam (13th), Rome (14th), Milan (15th), Vienna (18th) and Prague (19th).
Ann Cairns, President of International Markets, Mastercard said: “MasterCard understands the importance of cities around the world both for travelers and those who live there.
"This year’s study helps us understand just how interconnected the world’s cities are the significant role they play in connecting and empowering greater numbers of people than ever before.”
The latest results from the Office of National Statistics International Passenger Survey recently revealed that the capital welcomed over 17.4 million international visits in 2014 – more than ever before. This surge in visitor numbers reflects the ever evolving and expanding tourism offer in the capital, from world class exhibitions, blockbuster entertainment and major sporting and cultural events.
London's historic and cultural assets are key drivers in encouraging international visits to the city, and preparations are currently underway across the capital for the launch of the much anticipated London’s Autumn Season 2015.
The initiative from London & Partners, the Mayor’s official promotional company for London, will bring together the city’s most high-profile cultural institutions to promote the blockbuster exhibitions and events taking place later this year and strengthen London’s reputation as a global cultural powerhouse. Highlights for this autumn season include ‘Hamlet’ at the Barbican (starring Benedict Cumberbatch), ‘The World Goes Pop’ at Tate Modern, ‘Cosmonauts: Birth of the Space Age’ at the Science Museum, and ‘The Crime Museum Uncovered’ at Museum of London.
Other attractions for the year ahead in London include the opening of Shrek’s Adventure! London in July, a collaboration between Merlin Entertainments and DreamWorks Animation. The city will also host the third annual Prudential RideLondon, fully-electric racing series Formula E, the NFL International Series, and some of the biggest matches in the 2015 Rugby World Cup.
For more information go to www.visitlondon.com
Notes to Editors
A full copy of the report is available for download at http://bit.ly/1AI88uN
About London & Partners
London & Partners is the official promotional organisation for London, attracting and delivering value to business, students and visitors. We work to maintain London’s position as the number one international visitor destination in the world by marketing to established and emerging markets. We work with the travel industry to promote London to individual leisure travellers and groups worldwide.
For interviews and further information please contact Leisure Tourism Media & PR Manager Rebekah Clement on +44 (0) 20 7234 5861 / +44 (0) 7826 907415 or firstname.lastname@example.org
About the MasterCard Global Destination Cities Index
The MasterCard Index of Global Destination Cities ranks cities in terms of the number of their total international overnight visitor arrivals and the cross-border spending by these same visitors in the destination cities, and gives visitor and passenger growth forecasts for 2015.
Public data is used in deriving the international overnight visitor arrivals and their cross-border spending in each of the 132 destination cities, using custom-made algorithms; paying special attention to eliminate the hub effects for destination cities such as Singapore, Dubai, Amsterdam and Frankfurt.
This Index and the accompanying reports are not based on MasterCard volumes or transactional data.
For more information on the MasterCard Global Destination Cities Index, please contact:
Leah Selouk, Account Director, +44 (0)20 7611 3784 / email@example.com
Nicola Hanley Nicola Hanley, Account Director, +44 (0)20 7611 3597 / +44 (0)7843 573214 / Nicola.Hanley@Ketchum.com


text:
|Title||Effect of long-term oral administration of the Bacillus thuringiensis –endotoxin on microflora of large intestine in mice|
|Publication Type||Journal Article|
|Year of Publication||2011|
|Authors||Klimentova, EG, Kuptsova, AA, Kamenek, K, Gouli, V|
The authors studied the frequency of distribution of conditional pathogenic microorganisms and hemolytic strains of Escherichia coli and Staphylococcus aureus in microbiocenosis of mouse large intestine during dysbacteriosis, due to the action of Bacillus thuringiensis d-endotoxins. The appearance of conditional pathogenic microorganisms and strains of hemolytic E. coli and S. aureus in large intestine microflora during long-term of use of toxin high doses was revealed.
Effect of long-term oral administration of the Bacillus thuringiensis –endotoxin on microflora of large intestine in mice
Acknowledged VT EPSCoR:

domain: biology


text:
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text:
Cab drivers in New York, London and Tokyo form the backdrop for this unique and high-quality photo book. „Taxi Drivers. Written In Their Faces“ by Klaus Einwanger, curated by Sonya Winterberg and designed by Christian Grundl.
Most people associate cab driving in these cities with iconic vehicles: The Yellow Cabs in New York City, the black limousines of London, and the shiny polished Tokyo cabs. The personal stories of the drivers in these cities inspired internationally renowned photographer Klaus Maria Einwanger.
The daily existential worries of New Yorkers, the intrepidity of Londoners, and the distinguished pride of Tokyo drivers form the area of tension of Taxi Drivers. Written In Their Faces – an aesthetic and equally cosmopolitan discovery of a seemingly mundane microcosm.
The authentic portraits of the drivers also show the recent developments caused by ride-sharing apps like Uber. Einwanger's work visually documents the slow decline in values, masterfully photographed with Leica cameras. The faces portrayed tell of hope lost and desperate battles fought but also of combative spirit and creative protest.
His homage to the cab drivers of this world is both personal and universal - and, as he likes to point out, "written all over their faces."
- Credits -
Photographer: Klaus Einwanger
powered by Leica


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News of the day for March 8, 1978 - Coal Miners Strike hits 93rd day. Prime Minister Begin to Visit Jimmy Carter and continued Middle East Peace Talks. Holland is first NATO ally to reject deployment of Neutron Bomb. Recount going on in Guatemala from Sunday's election, citing mass vote fraud. Hustler Publisher Larry Flynt listed in critical condition after undergoing 2nd surgery from assassination attempt outside of a courthouse in Georgia.
Sean Hannity's been transmitting his Fox News show from Planet Wingnuttia all week, but last night managed to bring on a guest who comes from the even
(the never-ending saga of the Middle East - going back as far as the memory can see) Another warmup of the Wayback Machine - this time to March 14,


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A Catholic Mother’s Companion to Pregnancy: Walking with Mary from Conception to Baptism is the book I wish I had owned and read when I was going through my own pregnancies. Sarah Reinhard, a self-described “non-baby” person – even though she has three lovely children of her own, takes an honest and faith-filled look at pregnancy.
Part One offers a weekly journey through one’s pregnancy with information on what stage the child is at during this week, a faith-filled task for each week, a reflection on one of the mysteries of the rosary (one goes through the 20 mysteries twice during the full pregnancy), and a explanation about a particular aspect of the Catholic faith. Part Two focuses on labor and birth, while Part Three centers on preparing for and celebrating your child’s baptism.
I greatly appreciated Reinhard’s refreshing honesty about mixed feelings during pregnancy. So many pregnancy books seem to only emphasize the blessing and not acknowledge the inherent difficulties many women face during this time. As she puts it so well, “know that you’ll be blessed, even if the road to it feels like a pile of rocks to climb.”
I also thought that special topics dealing with difficult situations, written by other moms, were incredibly helpful. Topics such as Eating Disorders during Pregnancy, Tips for Handling Depression, Coping with Miscarriage, Giving Birth to a Child with Special Needs, Carrying a Baby to Term who Might Not Live, and When Labor Doesn’t Go as Expected are tough subjects to talk about, but they are topics that sorely need to be addressed. These women bravely share their stories in the hopes of helping others facing the same challenges.
This is also a very practical book, offering concrete ways of coping both during pregnancy and after birth. As is often said, a baby changes everything. Life will never be the same and those first few months can be especially taxing. Reinhard emphasizes the need to ask for help, and the difficulties inherent in that for many of us. She also makes valuable suggestions about how to incorporate prayer into your incredibly busy life.
If you are Catholic and pregnant, or know someone who is, A Catholic Mother’s Companion to Pregnancy is definitely a book you want to buy!


By Michael Ofulue, Osogbo
The Governor of Osun State, Senator Ademola Adeleke has said that plans are underway to launch palliatives to cushion the impact of subsidy removal.
To this end, he said his administration is putting every measures in place to make life easy for residents of the state.
The Governor made the disclosure at a stakeholders’ meeting of the Peoples Democratic Party (PDP) at its party’s office in Osogbo on Friday, stressing his conviction to run a government that bring smile on the faces of the people.
Adeleke who appreciated leaders of the PDP for their support since assuming office, noted that his administration has been working in line with “our election promises and the agenda of the party.”
While detailed projects and interventions implemented so far recorded by his government in the health, education and public infrastructure renewal.
“We have positioned the public service, build roads, bridges and channelisation. We have commenced payment of salary and pension debt.
“Your (PDP) government has launched the Osun digital economy agenda. Abandoned projects are being completed. Your government is beating old governance records within so short a period,” he stressed.
Speaking on plans to cushion the impact of fuel subsidy removal on Osun populace, Governor Adeleke pointed out that “We (Osun Government) will soon introduce public transport buses. We are working on adjusted work hours and days. We want to make live easy and enjoyable for our people.”
Adeleke assured party leaders and members that he will run an inclusive government that leaves no one behind, adding that “We will all be accommodated. We will be fair to all.”
“I appreciate your support then and now. This is your government. We shall all realize the fruits of our labour,” he said.
Earlier, former of Governor of the state, Olagunsoye Oyinlola in his message at the meeting recalled the initial skepticism on the governorship of Governor Adeleke and posited that under seven months the Governor has proved skeptics wrong.
He noted the superlative performance of the Governor which he said aided the electoral fortunes of the party at the state and national elections.
“Governor Adeleke has surprised even his worst critics. His performance impresses all and it has strengthened the party and the state. We commend the Governor and his team”, the former Governor who speaks for other stakeholders noted.
Other stakeholders of the party who spoke separately at the event also commended the Governor for robust performance and delivery of good governance in the last seven month


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Cassoulet Recipe Card Front
Front of the recipe card for Cassoulet.
Vintage Recipe Box 95
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- 1½ cups navy beans, soaked overnight in water to cover
- 1 large piece salt pork
- 2 lbs. lamb (preferable breast but can use lamb shanks or combination of shanks, lamb stew meat, etc.)
- 1 onion, cut in half and stuck with 5 or 6 cloves
- 2 carrots, scraped, cut in chunks
- 1 stalk celery
- 1 tsp. thyme
- 1 bay leaf
- Large piece of sausage
- Cook beans and salt pork in soaking water 1½ hours.
- In skillet, brown lamb, vegetables and salt pork that was cooked with beans.
- Add to bean pot, stir in seasonings and salt and pepper to taste.
- Place sausage on top.
- Bake in 225° F. oven for 2 hours, adding water as needed.