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Chinese Garden at the Montreal Botanical Garden
The Chinese garden is the fruit of bonds forged between the Parks Department of the City of Shanghai and the Montreal Botanical Garden. The concept of the garden was the work of Le Weizhong, renowned architect and master landscaper and the then (during construction in 1990-1991) director of the Shanghai Institute of Landscape Design and Architecture.
Nestled in the heart of Montreal Botanical Garden is the Dream Lake Garden, an authentic Chinese garden inspired by the private gardens in the southern Yangzi River region during the Ming dynasty (1368-1644).
This garden is unique. Rustic and asymetrical at first glance, it was nonetheless created according to a rigorous esthetic principle. It is both a place of contrast and harmony. The spatial organization and pavillions’ architecture, the selection of plants and minerals, the water and the contrast of yin and yang are all expressions of the secular principles of the Chinese art of landscape design.
Chinese gardens play havoc with perspectives and Western conventions Their components are laden with great metaphorical meaning A designer reproduces nature not by imitating it, but rather by interpreting it by creating a three-dimensional portrait. Shapes and masses are used to achieve contrast and arouse emotion.
For more information view: www.museumsnature.ca


Heart of the City Neighborhoods, Inc. is a not-for-profit corporation dedicated to creating affordable housing programs for Buffalo neighborhoods, helping to improve and strengthen the community.
Heart of the City Neighborhoods, Inc.
has provided Quality Housing Opportunities since 1998
Heart of the City Neighborhoods (HOCN) has worked together with residents, neighborhood organizations, financial institutions, and real estate professionals to make Buffalo’s core communities a better place to live. While our original housing programs worked to increase homeownership opportunities, our most recent programming has made an effort to stabilize homeownership through repairing occupied housing, as well as ensuring tenants have increased access to safe, affordable housing opportunities. Between 1998 and 2020, HOCN’s rehabilitation efforts invested over 29.6 million development dollars in Buffalo’s core communities.
HOCN is designated a New York State designated Neighborhood Preservation Company for the core communities in Buffalo, including the Lower West Side, West Side, Upper West Side, Allentown, Pratt-Willert, Central, MLK Park, Fruit Belt, Elmwood Bryant, and parts of Masten Park, Genesee-Moselle, and Broadway Fillmore communities. Over the past twenty-two years, HOCN has created and restored 473 units of quality, affordable housing, and provided 582 residents with quality, affordable housing. The impact of this work is both immediate and long-term, reaching the community on various levels.
Leveraged and invested in our communities
Units of quality affordable housing created and restored
Residents supported by our programs


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Social & Links
Centennial Center Park, 13050 E. Peakview Avenue, Denver‑ Centennial, CO 80111
Estimated attendance: 75,000
Bud Light, Colorado Proud, and Outlaw Nation are proud to present the 2021 Colorado (Denver) Music & Arts Festival at spectacular Westminster City Park, on May 29 & 30, 2021. Come and enjoy major concerts, fine art displays, a classic car show, a custom motorcycle show, and dozens of fun attractions and highlights. Check out the Taste of Denver Food Garden, with delicious cuisine, and cold domestic and craft beers. National recording artists will be performing throughout the afternoon and evening on the main stage, as well as juried visual artists presenting the heritage and the culture of our great city.
BRING THE WHOLE FAMILY FOR A FANTASTIC WEEKEND OF FUN!
WHEN: MAY 29-30, 2021, 11 AM – 9 PM
WHERE: WESTMINSTER CITY PARK, WESTMINSTER, CO
The Colorado Music & Arts Festival spans more than eight acres of stunningly beautiful landscape. There is plenty of open space to be alone with friends, and practice social distancing with strangers. We are abiding by all CDC and State of Colorado guidelines, to ensure that you have a safe and wonderful experience.
Come shop our incredible Artists Market, presenting the works of more than 80 talented visual artists. Featured art includes paintings, photography, sculpture, stained glass, and uniquely beautiful homemade jewelry, crafts, candles, and gifts. You’re going to love the bargains that you’ll find!
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domain: artistic


The University of Georgia’s diverse offerings in the visual, literary and performing arts is on display this November during the fifth annual Spotlight on the Arts festival, which features more than 100 events and exhibitions over 12 days.
The fifth annual festival began Nov. 2 with a kaleidoscope of student performances in an Opening Celebration at the Performing Arts Center. Continuing through Nov. 13, the arts festival includes art exhibitions and demonstrations, book talks and readings, film screenings and theater, music and dance performances, many of which are free and open to the public.
Created in 2012 by the UGA Arts Council, Spotlight on the Arts celebrates the visual, literary and performing arts at UGA. This year’s festival includes performances of “Jane Eyre” presented by University Theatre as well concerts from a dozen student and faculty groups from the Hugh Hodgson School of Music, exhibitions at the Lamar Dodd School of Art and Georgia Museum of Art and performances from the department of dance’s Young Choreographers Series.
A special daylong Student Spotlight event Nov. 3 featured student performances at Tate Plaza. On Nov. 5, the first Spotlight on the Arts Family Day included performances, activities, demonstrations and workshops in art, dance, theater, music and writing designed for children and families to enjoy.
Other highlights of the festival include a talk and DJ set from acclaimed music producer Jacknife Lee, a Shakespeare symposium, lectures from internationally renowned artists and scholars and guest performances from the Chamber Music Society of Lincoln Center, folk music group The Dardanelles and the Atlanta Symphony Orchestra.
“The mission of the Arts Council is to foster an awareness and appreciation of the arts and to create an environment conducive to artistic innovation,” said Vice Provost Russell Mumper, who chairs the Arts Council. “Although arts are an ever-present fabric of UGA, this festival allows us a special opportunity to shine a spotlight on it.”
Members of the UGA Arts Council include representatives from the Office of the Senior Vice President for Academic Affairs and Provost, the creative writing program, the department of dance, the department of theatre and film studies, the Franklin College of Arts and Sciences, the Georgia Museum of Art, The Georgia Review, the Hugh Hodgson School of Music, the Lamar Dodd School of Art, the Performing Arts Center, the UGA Press, the special collections libraries and the Willson Center. Also contributing to the 2016 Spotlight on the Arts festival are the College of Environment and Design, Ideas for Creative Exploration and the Grady College of Journalism and Mass Communication.
Many of the performances are free or discounted for students. Events presented by the Performing Arts Center, dance department, Hugh Hodgson School of Music and University Theatre will be available for purchase online at www.pac.uga.edu, at the PAC box office or by phone at 706-542-4400 (toll free at 888-289-8497).


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There is no stopping the emerging entertainment company Legacy Entertainment from conquering the country’s music industry as it combines its founders’ distinct business acumen and individual skills in introducing new talents. From production services to talent management, talent launching, and writing services, the company is a one-stop shop for aspiring and existing artists in the industry who want to create a lasting impact on this generation.
Inspired by the idea of providing an avenue for artists to share their talents on powerful platforms, founders Steven Middleton, Rondell Cobbs (better known as Beatz), and Edwin Camacho thought it best to embrace this new season and combine their unique backgrounds and over 40 years of combined experience. By putting their skills and expertise together, they are establishing an entertainment powerhouse that has the ability to grow the dreams of music artists.
“Being in the industry for many years, seeing and learning many things both good and bad, shaped the beginning of this idea for all three founding members. We saw a hole we felt we could fill. Treating people the right way for the long term and building the foundation with integrity where everyone involved feels safe and secure is our vision. Doing this allows massive amounts of inspiration to flow between each other along with the work we do. Legacy wants to help connect the best talent in the world to the right opportunities on every level possible, and their hard work speaks for itself, leaving a positive legacy one deal at a time,” shared the Legacy Entertainment founders.
To officially make their mark in the music industry, the company will be launching a rising and promising music artist, Meaghan Rose, whom the company just recently signed. Her debut single will be launched in October this year while her full album will make an explosive launch in January 2021. The album will be called Rose’ilium. To help the company launch her personal brand, Middleton, Cobbs, and Camacho will be working closely with well-known talent manager Joshua Mitchell. The founders are confident that just as Meaghan Rose has made an instant connection with their musical style and preferences, she will also easily attract music lovers with her upcoming debut single.
“We want them to know that Legacy is here to help establish upcoming artists, producers, songwriters, engineers, and creatives get to the level in their career that they have always dreamed of,” the founders added.
Legacy Entertainment is all about creating lasting working relationships with music talents from all over the country. Aside from looking for promising artists to invite to become part of their company, they are also looking at adding reliable and gifted producers and songwriters to come on board. Respected songwriter and producer Allan Edwards will be partnering with the founders all the way from Atlanta, Georgia.
For the people behind Legacy Entertainment, the future is looking very bright for them, as music personalities are taking notice of their powerful potential. With their determination to become a household name in the music industry, only the best services can be expected to come from their team. Aside from managing talents, the company also aims to someday become a label company and be home to the next generation of superstars.
Learn more about Legacy Entertainment by visiting their website, Facebook, and Instagram.


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Posted on December 4, 2021
UDP-Galwas synthesized as described  previously
UDP-Galwas synthesized as described  previously. has shown to be an effective strategy for the introduction of anti-fungal medicines as the fungal cell wall structure plays an essential part in host-pathogen relationships and is vital for maintaining cell integrity . The cell wall structure includes an set up of polysaccharides, composed of branched mainly ?1,3-glucans cross-linked NKP-1339 to chitin with an exterior primary of galactomannan and glucan . The galactomannan primary is CDKN2B the main antigen created during disease  and is made from branched mannose including galactofuranose (Galnon-reducing end products [4C6]. Galis a five-member cyclic hexose within many pathogens but absent in human beings . The formation of Galstarts in the cytosol where UDP-Galis changed to UDP-Galby the flavoenzyme UDP-Galmutase (UMG, Fig. 1). UGM is vital for pathogenesis in  and larva hatching and motility in the nematodes and [9C11]. Deletion from the UGM gene in leads to depletion of Galsynthesis. Right here, we present the effective implementation of the fluorescence thermal change assay referred to as ThermoFAD to display for inhibitors of UGM (AfUGM). This assay screens the fluorescence from the Trend destined to AfUGM during thermal denaturation tests to calculate the melting temperatures (Tm) [15,16]. Boost from the Tm worth in the current presence of little molecule shows that the substance is binding towards the protein. Applying this assay, a kinase inhibitor collection was screened against flavopiridol and AfUGM was defined as a potential inhibitor. Addition of the substance to a remedy of AfUGM led to a rise in the melting temperatures, suggesting a protein-ligand complicated with higher balance is shaped. Isothermal titration calorimetry studies confirmed the complicated formation having a KD worth of 38 M. Inhibition research monitoring the mutase activity demonstrated that flavopiridol features as a noncompetitive inhibitor. Docking research claim that flavopiridol binds in the energetic site. Flavopiridol, known as Alvocidib also, can be an inhibitor from the NKP-1339 CDK kinases and happens to be under clinical tests for the treating severe myeloid leukemia. 2.?Methods and Material 2.1. Components Buffers, antibiotics and bacterial development media were from Fisher Scientific (Pittsburg, PA) and Sigma-Aldrich (St. Louis, MO). Turbo BL21 (DE3) chemically skilled cells were from Genlantis (NORTH PARK, CA) and pVP55A vector was from the guts for Eukaryotic Structural Genomics in the College or university of Wisconsin-Madison . For proteins purification, immobilized metallic affinity chromatography (IMAC) was found in an AKTA excellent program from GE Health care (Chicago, IL). Acquity ultra-performance liquid chromatography (UPLC) and Amide (1.7 m, 2.1 mm 100 mm) analytical columns had been from Waters Co. (Milford MA). NADPH was from EMD Biosciences (Billerica, MA). UDP-Galwas synthesized as described  previously. Kinase Inhibitor Library (L1200) was from Selleckchem (Houston, TX). The fluorescence thermal change assay was performed within an RT-PCR (Applied Biosystems 7300) using 96-well RT-PCR plates (Microamp 4306737) and optical adhesive movies (MicroAmp 431197971). Isothermal titration calorimetry (ITC) measurements had been performed in Auto-ITC 200 from Malvern Musical instruments (Alvern, UK) and examined using the Microcal Source edition 7.0 (OriginLab). Flavopiriol was bought from ApexBio (Houston, TX). 2.2. Purification and Manifestation of the. fumigatus M and UGM. tuberculosis UGM AfUGM was expressed in the vector pVP55A while reported  previously. Quickly, 6-L of terrific-broth (TB) car induction media including 100 g/mL ampicillin had been inoculated with 8 mL of over night tradition of BL21 Turbo cells changed using the vector pPV55A and incubated at 37 C until an optical denseness at 600 nm (OD600) worth NKP-1339 of 3 was reached, of which stage the temperatures was lowered to 18 C as well as the ethnicities had been incubated for 18 extra hours. Cells had been gathered by centrifugation at 5000xfor 20 min at 4 C. The ultimate wet-cell pellet (75 g) was kept at ?80 C. For proteins purification, the cell paste was resuspended in 250 mL of buffer A (25 mM HEPES, 300 mM NaCl, 25 mM imidazole, pH 7.5) and incubated with 25 mg/mL of lysozyme, DNAse I, and RNAse for 45 min at 4 C with regular stirring. The ensuing option was sonicated within an ice shower for 15 min at 70% amplitude with cycles NKP-1339 of 5 s on and 10 s off. The lysate was centrifuged at 45,000.

domain: biology


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A bombshell new report by charity Persecution Relief has shown that hate crimes against Christians in India rose by nearly 41 percent in the first half of 2020, despite widespread lockdown measures being put in place since March 25, as a result of COVID-19. The report stated that “293 cases of persecution against Christians reported in the first six months of 2020 included five religious-motivated rapes and six religiously-motivated murders”. Persecution Relief said most of these attacks were committed by Hindu nationalists, who are determined to turn in India into a Hindu state.
Horror stories have continually been reported, in which Christians, and Christian aid workers, have been targeted, and in some cases left to die as the decades-long fight over religion in India continues to reign.
The report came just days before more than 60 Christians, including many women and children, were barricaded inside a church after a gang of 50 religious fanatics confronted them at a church in Karnataka.
John Paul-son, of Pastor George who leads the church, detailed how the “mob grabbed me”, before he was “beaten and abused”.
Although police arrived to help those locked inside the church, the worshipper explained that the “mob was not afraid” of the authorities and continued to attack the Christian worshippers.
He said: “They beat us in front of them and forced the whole congregation, including women and children, to proceed to the police station.”
He added: “The young men who came to harm us were so full of rage and uttered despicable words against us.
“I do not understand the hate they projected towards us, when we have never done anything against them in the first place.
“However, we still chose to forgive them and pray for them.”
JUST IN: Archaeology breakthrough: Treasure-laden shipwreck from Crusades-era
These incidents have become all too familiar in India, and in one heartbreaking recent attack, another worshipper – Pastor Balvinder Bagicha Bhatti – was found dead on the side of a road in Punjab.
His body was beaten and bloodied, and his family argued that he had been assaulted although local police recorded his death as “accidental”.
A week after Pastor Bhatti’s death, Hindu radicals stopped a family in Jharkhand from holding a Christian burial, demanding they conduct a funeral in accordance with the village’s Hindu faith.
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It is in areas such as Jharkhand where Hindu violence is often aimed towards Christian worshippers.
Despite the rise in attacks, the US Commission on International Religious Freedom has downgraded India to a ‘Country of Particular Concern’, its lowest ranking, in its most recent report.
India is ranked alongside the likes of Iraq and Afghanistan by the US department, while the nation is now ranked just behind Iran by the ‘Open Doors’ World Watch List’ for persecution severity.
Source: Read Full Article

domain: law


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Xylitol and Ear, Nose and Throat InfectionsRecurring middle ear infections pose a great health threat to children. Tubes are often inserted into the ear drum in children with these recurring infections to reduce the fluid that is attempting to wash out the infection from the middle ear. While this procedure sometimes helps to reduce the frequency of infections, it is also designed to help with hearing.
Language, a critical part of learning, is built by auditory input during the first two years of life--the same period when ear infections are most common. If this input is dampened by infection or fluid in the middle ear during this important period, it can cause learning problems. One researcher demonstrated that even when properly treated, recurrent middle ear infections during the first two years result in significant impairment in reading ability up to the age of nine.7 Another study followed children longer and showed significant learning and social problems extending up to age eighteen.8
One of xylitol's versatile benefits is its ability to inhibit the growth of bacteria that cause middle ear infections in young children. In two recent studies involving over 1,000 children, xylitol-flavoured chewing gum was found to reduce the incidence of middle ear infections by 40 per cent, significantly decreasing ongoing middle ear complications and the need for antibiotics.
Regularly washing the nose with a spray containing xylitol decreases the number of harmful bacteria and stimulates normal defensive washing of this area. A clean nose reduces problems with allergies and asthma that originate from nasal irritants and pollutants. Current research shows how bacteria attach to cells in the body, causing infection. Some sugars like xylitol are known to be able to interfere with this binding, blocking the attachment of the major infection-causing bacteria that live in the nose. Dr Lon Jones, a physician in Plainsview, Texas, reported that the use of a xylitol nasal spray in his practice prevented 93 per cent of ear infections and resulted in comparable reductions in sinus infections, allergies and asthma.9
Xylitol has been shown to be effective in inhibiting Candida albicans, a serious systemic yeast problem, and other harmful gut bacteria including H. pylori, implicated in periodontal disease, bad breath, gastric and duodenal ulcers and even stomach cancer.
#1 Publisher of Alternative Cancer Treatments
The Righteous Brothers - I Believe
God Bless Everyone & God Bless The United States of America.

domain: medical


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NAG file SC petition to rescue grounded airline1 min read 07 May 2019, 06:37 PM IST
Jet Airways halted all flight operations indefinitely on 17 April after its lenders rejected its plea for emergency funds
The petition filed by NAG on Tuesday sought an appropriate order from the apex court directing the SBI ‘to provide all necessary interim finance’ to restart the airline
New Delhi: Jet Airways (India) Ltd’s pilots union, the National Aviators Guild (NAG), has approached the Supreme Court, asking it to help rescue the grounded airline.
Select your Category

domain: news


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NEW DELHI: As the controversy over the arrest of Jawaharlal Nehru University students on the charges of sedition, continues to play out, here is a recap of the developments:
Application submitted to hold event on Feb 9, titled “Poetry Reading - The Country Without Post.” Permission granted.
Posters put up stating that the event is “against the judicial killing of Afzal Guru” and in solidarity with the people of Kashmir.
Event goes ahead as planned. Event joined by “masked outsiders” and sloganeering between two groups disrupts the event. Alleged “anti-national” slogans were shouted, being countered by the second group composed of ABVP members at JNU.
Incidentally, Zee News was present for the entire duration of this event. They had been invited and signed in by ABVP members - as the JNU gate log shows. The District Magistrate has asked Zee News for the raw footage from the event; sources say that this has not yet been provided.
JNUSU President Kanhaiya Kumar says that he arrived at the scene only to break up the clash between the two groups. Both groups marched to Ganga Dhaba.
Police in plain clothes were present at the event. No FIR was lodged at this stage. No effort was made to stop and identity the masked people shouting slogans.
Video footage of the event was telecast on Zee News.
Since then, this footage has been shown to be doctored (3 of 7 videos from the event are doctored according to Hyderabad-based Truth Labs as submitted in a report by the District Magistrate on 2 March 2016).
JNU sets up a proctorial committee to inquire into the event.
Prime Time news dedicated to incident. Over the course of the next few days, at least three channels, Times Now, News X and Zee News played the version of video that has since been confirmed to be doctored.
Times Now’s Arnab Goswami tells Umar Khalid that he is a danger to the country and “anti-national.”
Maheish Giri, the BJP Lok Sabha member from East Delhi lodges an FIR against 'anti-national' students of Jawaharlal Nehru University who opposed the death penalty to parliament attack convict Afzal Guru.’
Kanhaiya Kumar addresses the students at JNU. Mainstream media makes no mention of this speech when news of Kumar’s arrest breaks.
Home Minister Rajnath Singh warns of "strongest possible" action against those involved in raising anti-India slogans.
SAR Geelani, former Delhi University Professor, slapped with charges of sedition for sloganeering at an event at the Press Club of India.
Kanhaiya Kumar arrested on charges of sedition. Charges also slapped on five other students.
JNU inquiry committee names eight students to be debarred. Action criticised as committee debars the students without a hearing and within a day.
Delhi Chief Minister Arvind Kejriwal ordered a magisterial inquiry into the JNU incident.
Protests in support of the students at JNU and against the arrest of Kanhaiya Kumar spread.
Congress Vice-president Rahul Gandhi visits the campus
Rajnath Singh linked JNU slogan shouting to LeT leader Hafiz Saeed. "I also want to make it clear that the JNU incident has the support of LeT chief Hafiz Saeed. We should also understand this reality that Hafiz Saeed has supported this incident and it is extremely unfortunate,” Singh told the media. Rajnath Singh retweeted a tweet from Hafiz Saeed claiming the JNU attack. Delhi Commissioner of Police BS Bassi also retweeted the tweet.
Tweet relied on by HM Singh and DCP Bassi turned out to be from a fake account.
Violence breaks out at Patiala House court as Kanhaiya Kumar is to be produced. Alleged lawyers attack students, professors and journalists. Kanhaiya Kumar’s police custody extended.
Delhi Police Commissioner BS Bassi tells the media, "Kahaiya Kumar had joined the meeting in the campus where anti-national slogans were raised. He also raised these slogans."
SAR Geelani formally arrested.
Delhi High Court rejects petition seeking NIA probe into JNU incident.
Delhi journalists stage a protest march against violence at Patiala Court.
Students at Jadavpur University shout slogans and organise a torch rally to show solidarity with Kumar.
Protest and support rallies spread. Messages of solidarity come pouring in.
Supreme Court takes note of violence at Patiala House. Orders strict guidelines to be followed and gives responsibility of law and order to Delhi police.
Violence at Patiala House again breaks out. Kanhaiya Kumar assaulted by lawyers within Court premises.
Supreme Court constitutes a panel of lawyers to look into the matter.
Academics, scientists, writers from across the world send solidarity messages, including Noam Chomsky and Nobel laureate Orhan Pamuk. 455 academicians from universities across the globe signed a petition which read: "JNU stands for a vital imagination of the space of the university - an imagination that embraces critical thinking, democratic dissent, student activism, and the plurality of political beliefs.”
Three JNU ABVP office bearers resign. “We can’t be mouthpiece of such a govt. which has unleashed oppression on student community, legislature like O P Sharma, govt. which has legitimized the action of right wing fascist forces either in Patiala house court or in front of JNU north gate.”
SC rejects Kumar's bail plea, asks his counsel to move the high court, saying SC hearing the plea would set a bad precedent.
India Today showed how the footage being circulated as ‘clinching proof’ of Kanhaiya Kumar’s and other students’ involvement in shouting “anti national” slogans could be doctored.
Umar Khalid's family allegedly receive death threats.
Other sedition-accused students remain missing (they have since said that they were waiting for the situation to calm down, fearing for their lives).
A producer of Zee News, Vishwa Deepak, resigned from the channel, asking whether it was “in nexus with the Delhi Police?” “Are we the mouthpieces of the BJP or the RSS that we will do whatever they say? The video didn't have any "Pakistan Zindabad" slogans at all – yet we played it repeatedly to spread madness and mayhem.”
Thousands joined a solidarity march in New Delhi as part of the #StandWithJNU movement.
NHRC slams Delhi police for not doing enough to protect Kanhaiya Kumar from the violence at Patiala House. NHRC said statement released by the police as an appeal by Kanhaiya was not written by him voluntarily, and added that Kumar had been subjected to “psychological pressure” by the police.
Case transferred to the Delhi Police Special Cell.
Delhi High Court hears Kanhaiya Kumar bail plea. Raps Delhi police: “Do you know what sedition even is?” Reserves orders for March 2.
Umar Khalid and Anirban Bhattacharya police custody extended by one day.
Anant Prakash Narayan, one of the students accused of sedition, writes an open letter to Smriti Irani based on her speech in Lok Sabha. “As well as taking charge of the Ministry of Human Resource Development, it is expected that you take responsibility of this country’s central universities, while respecting their autonomy. What you did in the matter of Rohith Vemula is evident to everyone; the pressure that you put on the university administration came forth in the form of Rohith’s institutional murder.”
Umar Khalid and Anirban Bhattacharya sent to 14 day judicial custody.

domain: politics


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From Corpus Christi. Texas. Lauren has been creating art from a young age.
I have used many different mediums. Currently I am working on Yupo Paper with Prisam Color art markers.
I use patterns and images from my life and nature to inspire my designs. I also try to incorporate chakra healing energy.


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The Heat has had to come back from some pretty big second-half deficits, such as 27 points to Cleveland midway through the third quarter and 13 points to Boston with 8:26 left in the fourth. Nothing has come easy for Miami. Even the lowly Charlotte Bobcats, owners of the NBA's worst record (currently 16-54, .229) jumped out to a 19-8 lead over the Heat last Sunday, before Miami came back and took control.
In a previous posting, I noted that, in contrast to this year's Heat, the 1971-72 Lakers rarely seemed to have trouble during their 33-game streak. However, that conclusion was based only on final margins of victory, without taking into account the possibility that the Lakers struggled early in games and only pulled away toward the end.
I have now gone back and looked at the Lakers' 1971-72 game-by-game log, to get more detail on each of the team's games during the streak. Specifically, I checked the quarter-by-quarter line score, which is part of the box score for each game. To take an example, in the Lakers' December 3, 1971 game at Philadelphia, which was L.A.'s 16th win during the streak, the line score of points per quarter read as follows (I added the cumulative score at the end of each period in parentheses).
|Lakers||19||39 (58)||36 (94)||37 (131)||131|
|76ers||30||39 (69)||24 (93)||23 (116)||116|
I then plotted the Lakers' leads or deficits at the end of each quarter, for each game during the streak. Also, to get an idea of how L.A. did against opponents of varying quality, I made separate plots for games against top-tier (.537 winning percentage and above), middle-tier (.439-.512), and bottom-tier (the expansion Buffalo, Cleveland, and Portland clubs, all of which finished last in their respective divisions) opponents, based on teams' records in the preceding, 1970-71 season. (The Lakers did not play against the Cincinnati Royals, who were .402 in 1970-71, during the streak.)
As the first graph shows, in games during the streak against top opponents, the Lakers tended to hold modest leads after the first quarter, which they gradually expanded over the course of the game. The bottom curve represents the above-described Philly game, in which L.A. trailed by 11 points after the first and second quarters, led by 1 after three quarters, and won by 15. The one game touching the break-even point (red line) after four quarters was a December 10, 1971 overtime win over Phoenix, the Lakers' 20th win during the streak. In that game, the Lakers failed to hold a 12-point lead over the Suns after three quarters. The box score shows Wilt Chamberlain going 0-for-6 from the free-throw line overall; if some of those attempts took place in the fourth quarter, that could explain Phoenix's comeback.

domain: game


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|SS 347||1.4550||S34700||SUS 347||08Ch18N12B||X6CrNiNb18-10|
|SS 347H||1.4961||S34709||SUS 347H||-||X6CrNiNb18-12|
|SS 347||0.08 max||2.0 max||1.0 max||0.045 max||0.030 max||17.00 - 20.00||10xC – 1.10||9.00 - 13.00||62.74 min|
|SS 347H||0.04 – 0.10||2.0 max||1.0 max||0.045 max||0.030 max||17.00 - 19.00||8xC – 1.10||9.0 -13.0||63.72 min|
|Density||Melting Point||Tensile Strength||Yield Strength (0.2%Offset)||Elongation|
|8.0 g/cm3||1454 °C (2650 °F)||Psi – 75000 , MPa – 515||Psi – 30000 , MPa – 205||35 %|
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text: Introducing the perfect men's trousers for any occasion, our apple chinos have been designed to look modern and fresh this Spring/Summer! Perfectly combining style and practicality, these slim fit trousers will enhance your silhouette effortlessly. Whether you are heading out for a casual lunch with friends or stepping into the office, these best men’s chino trousers can be quickly dressed up or down for any situation. Make it a semi-casual look with one of Gurteens checked shirts, must-have outfit combination for this season. For an even more sophisticated vibe, top off the outfit with one of our best men’s jackets, now that's style!

domain: design


text:
All the Mets have their name on a placard, and when the lineup is posted each day in the clubhouse, the placards are slotted in assigned racks designating the batting order.
Yesterday afternoon when the clubhouse opened to the media 3½ hours before the game with the Astros, the placards were halfway in their slots, aside from scheduled starter Tom Glavine. In other words, nothing was set.
That’s not the first time the lineup needed some time to be determined, but last night it was a pretty good bet the uncertainty stemmed from how banged up the Mets were. If you consider Miguel Cairo the starter at second base, then, incredibly, six of the eight starting Mets position players were hurting.
Mike Piazza had a left-wrist contusion. Doug Mientkiewicz was suffering from a bruised rib on the right side and a right pectoral contusion. Cairo had been out with a tight left hamstring. Meanwhile, the entire outfield – Cliff Floyd (left hand stepped on during Wednesday’s game), Carlos Beltran (strained right quad) and Mike Cameron (ailing right quad) – was banged up.
In fact, only the left side of the infield – David Wright and Jose Reyes – was fully healthy.
“I know we’ve got nine [players],” Willie Randolph said. “That’s all I want is nine, that’s all. We’ve got enough.”
The good news, at least, was that none of the injuries was too serious. And several of the Mets were progressing. Beltran had been back for each game of this homestand. Cameron hasn’t missed any time. And Floyd said yesterday his hurting hand was tolerable.
“It’s all right,” Floyd said. “Playing for sure.”
Cairo also was improving. The second baseman left a game on June 1 with the tight left hamstring, and his only appearance since came when he pinch hit in the second game of Sunday’s doubleheader against the Giants.
Cairo said yesterday, “I’m fine,” noting he now can play.
Still, Randolph had Kazuo Matsui in the lineup again at second base, saying he wanted to be careful with Cairo before putting him back out there.
“I’m still going to give him an extra day,” Randolph said. “I always like to do that with hamstrings.”
As for Piazza, he took a foul ball off his left wrist in the first inning of Wednesday’s game and had to exit after the top of the frame. He said yesterday he was improving.
“Feel a little better,” he said. “We’ll see. It’s still a little sore.”
Piazza said playing this weekend was a possibility, and it appeared the disabled list was a highly unlikely option. Said Piazza, “It’s not a major thing right now.”
The Mets could be in better shape with their backstop situation. Ramon Castro played the bulk of Wednesday’s game and was in the lineup again last night. But Randolph said Castro was hurting, too, noting, “I think when he dove back to first base [Wednesday night] he jammed his finger.” So, basically, neither Mets catcher was completely healthy.
Finally, there was Mientkiewicz, who said he was optimistic of playing tonight. Chris Woodward got the start at first base last night, and though Woodward is a capable player, all these injuries meant that not only were the starters hurting but the bench was limited, as well.
Randolph said right now the team would stay with 12 pitchers and didn’t plan on doing anything to recall an extra position player to provide depth. So the Mets simply have to get healthy – and do it fast.

domain: sports


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Crypto security startup Curv is rolling out a new decentralized finance (DeFi) solution that it says will make it easier for institutions to access DeFi apps.
Curv DeFi will build on the startup's integration with the Compound protocol earlier this year as well as its recent partnership with ConsenSys. According to a Thursday announcement, Curv DeFi will use the interoperability and user interface of ConsenSys-owned MetaMask to provide its clients with "a unique offering that combines ease-of-use with the enterprise-controls and enforcement mechanisms institutions require to build out their DeFi strategies."
Still, it is not clear exactly how many firms are lined up to use the solution. In a statement to The Block, Curv said it has "a handful of existing clients." It declined to share the names of those clients.
"As there is no reliable and secure institutional solution for DeFi, we've seen organizations revert to retail-level MetaMask," a company spokesperson told The Block. "The new joint offering will enable institutions to combine the ease of use and application-readiness of MetaMask together with an enterprise-grade security infrastructure Curv offers."
When asked to elaborate on how it would do this, a representative of Curv responded: "Our partnership with MetaMask means that users will be able to keep the same workflow they are accustomed to, while gaining all the security benefits that institutions require. We’ve just bridged the technology gap, and paving the way for greater institutional adoption of DeFi."


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The judge at the head of the inquest into Princess Diana’s death has determined that the royal family had no part in the accident and there is no conspiracy whatsoever.
Diana passed away after being chased by paparazzi in Paris in 1997 with her companion, Dodi al-Fayed. Since that day, there have been competing theories about the princess’ death, many with the royal family at its heart.
After hearing from over 250 witnesses, Lord Justice Scot Baker informed the jury that he had reached his decision with the following statement.
“There is no evidence that the Duke of Edinburgh ordered
Diana’s execution and there is no evidence that the security
intelligence service or any other government agency organized it.”
With that statement, the inquiry into Princess Diana’s d
eath should be a closed case. Now each investigation into
Diana’s death has determined the same cause – driver Henri Paul
was driving too drunk and too fast.


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Role of Endoplasmic Reticulum Stress in Proinflammatory Cytokine-Mediated Inhibition of Trophoblast Invasion in Placenta-Related Complications of Pregnancy.
Shallow extravillous trophoblast (EVT) invasion is central to the pathophysiology of many pregnancy complications. Invasion is mediated partially by matrix metalloproteinases (MMPs). MMP-2 is highly expressed in early pregnancy. MMP activity can be regulated by proinflammatory cytokines, which also induce endoplasmic reticulum (ER) stress in other cells. We investigated whether proinflammatory cytokines regulate MMP-2 activity through ER stress response pathways in trophoblast before exploring potential regulatory mechanisms. There was increased immunoreactivity of heat shock 70-kDa protein 5, also known as 78-kDa glucose regulated protein, in cells of the placental bed, including EVTs, in cases of early-onset preeclampsia compared with normotensive controls. Treating EVT-like JEG-3 and HTR8/SVneo cells with ER stress inducers (tunicamycin and thapsigargin) suppressed MMP2 mRNA and protein expression, secretion, and activity and reduced their invasiveness. A cocktail of proinflammatory cytokines (IL-1β, tumor necrosis factor-α, and interferon-γ) suppressed MMP-2 activity in JEG-3 cells and was accompanied by activation of the PKR-like ER kinase (PERK)-eukaryotic translation initiation factor 2A (EIF2A) arm of the ER stress pathway. Knockdown of ATF4, a downstream transcriptional factor of the PERK-EIF2A pathway, by small interference RNA, restored MMP2 expression but not cellular proteins. However, suppression of EIF2A phosphorylation with a PERK inhibitor, GSK2606414, under ER stress, restored MMP-2 protein. ER stress regulates MMP-2 expression at both the transcriptional and translational levels. This study provides the first mechanistic linkage by which proinflammatory cytokines may modulate trophoblast invasion through ER stress pathways.


text:
Michael G. Kemp, Ph.D. (Advisor); Ravi P. Sahu, Ph.D. (Committee Member); Yong-jie Xu, M.D., Ph.D. (Committee Member)
Master of Science (MS)
Cisplatin is a DNA damage-based chemotherapeutic drug widely used to treat various types of cancers; however, the treatment's toxicity restricts its efficiency. Studies have shown that the circadian rhythm controls the DNA damage response and affects the repair pathways of cisplatin-induced DNA damage. Circadian clock modulation, therefore, has been proposed to be a potential mechanism for enhancing cisplatin tolerability. Here we used clock-enhancing molecules to evaluate the effect of pharmacological clock modulation on cisplatin cytotoxicity. Using cultured human cell lines, cisplatin cytotoxicity was found to be attenuated following treatment with circadian-enhancing molecules KS15 and SR8278. Moreover, the protein and mRNA levels of cell cycle and apoptosis regulators, as well as clock-controlled genes, were modified in response to KS15 and SR8278. Those molecules were also able to enhance cisplatin-induced DNA adducts removal and induce G1-phase cell cycle arrest. Our findings suggest that the use of circadian clock modulators has promising implications for improving cancer care and treatment outcomes
Department or Program
Department of Pharmacology and Toxicology
Year Degree Awarded
Copyright 2021, all rights reserved. My ETD will be available under the "Fair Use" terms of copyright law.

domain: chemistry


Discover the Time Out Markets
Miami’s newest destination for eating and drinking features the city’s top chefs, most-talked-about restaurants and buzziest bars – plus the latest in arts and culture – all huddled together under one roof. You’ll find us cooking up a storm in South Beach.
Heading to the monumental Landmark Center near Fenway Park, Time Out Market Boston brings together the best of the city (and the wider Boston area) under one roof – including two new concepts from the team behind one of the city’s most awarded restaurants.
What do New Yorkers crave more than anything else? Options, and damn great ones. For Time Out Market New York (coming soon to Dumbo), our editors have curated 21 eateries, three bars and scores of cultural exhibitions that represent NYC’s local flavour right now.
Open since 2014
Time Out Market Lisbon is the first market in the world where everything has been chosen, tasted and tested by an independent panel of city experts: Time Out’s own journalists and critics. If it’s good, it goes into the magazine; if it’s great, it goes into the market.
For 50 years, Time Out has discovered and championed the best of city culture, from art to theatre and clubbing to food and drink. Now that curation has leapt out of our magazine and web pages and into physical reality as Time Out Market – and we’re on our way to Chicago, Montreal, London, Prague and Dubai.
Latest news from Time Out Market
Feeling hungry? You will be once you’ve taken a peek inside the new Time Out Market Miami.
Five years ago, Time Out editors created one of the world’s best eating spots in an old Lisbon landmark. Discover its story and find out what’s next.
The day has finally come – today we reveal the best of the city under one roof!
No more teasing you with the promise of a good time at South Beach’s newest destination for all things food and drink: Time Out Market Miami will officially open its doors to the public on May 9, 2019.
Building off the excitement of its first wave of chefs and restaurateurs, Time Out Market Boston has revealed the next slate of culinary all-stars who will be setting up shop at 401 Park Drive.


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2012 was a year filled with great music. From viral videos to new artists to the explosion of EDM, there was no shortage of entertainment. We’ve compiled a handy list of the 25 best songs of the year for your listening pleasure.
25. “Payphone” – Maroon 5 ft. Wiz Khalifa
Maroon 5’s “Payphone” was catchy enough to get stuck in your head for days, featured mega-popular rapper Wiz Khalifa, and was an anthem for every young girl who was sick of having her heart broken. “One more stupid love song, I’ll be sick,” sang frontman Adam Levine. Me too, Adam…me too.
24. “HYFR” – Drake ft. Lil’ Wayne.
In case some of you out there still didn’t get it, HYFR stands for “Hell Yeah, F**kin’ Right.” It’s a pretty explicit song, but Drake’s swagger shines in all its glory with Lil’ Wayne’s signature drawl backing him up.
23. “Ho Hey” – The Lumineers
Even if you don’t know what song this is, I guarantee you’ve heard it in stores, soundtracks, and on the radio. The Lumineers’ hit crossed over from indie charts to pop charts and became an instant success.
22. “How We Do” – Rita Ora
2012 was Rita Ora’s year. The woman made a name for herself as a cross-genre artist and a fashion icon. Her hit “How We Do” borrowed lyrics from Biggie Smalls’ “Party and Bullshit,” showing us that British girls have swag too.
21. “Mercy” – Kanye West ft. Big Sean, Pusha T and 2 Chainz
“Mercy” was one of the first tracks to push 2 Chainz to the top of the charts and of course, with Kanye at the helm of this great track would we expect anything less? Don’t tell me you don’t excited everytime you hear Fuzzy Jones’ incoherent yelling at the beginning of the track.
20. “Simple Song” – The Shins
The Shins’ first single in five years featured a completely re-shufled line-up with only lead singer James Mercer remaining as an original band member. Their first single showed off a new, refreshing, positive sound and set the tone for a strong fourth album release.
19. “Bangarang” – Skrillex ft. Sirah
2012 was also the year EDM became a mass-popular genre. Everyone and their mother listened to some form of Electronic Dance Music, with producer Skrillex making dubstep a mainstream genre. His club-banger “Bangarang” made everyone just let loose and dance hard.
18. “Get Free” – Major Lazer
Major Lazer’s “Get Free” showed us the producer’s mellow side, with Amber Coffman from the Dirty Projectors lending a hand to the project. It’s smooth, it’s slow, and it’s perfect.
17. “Houdini” – Foster the People
Foster the People’s first hit “Pumped Up Kicks” has nothing on “Houdini.” The perfect harmonies, the mixture of piano and electronic elements, and lead singer Mark Foster’s confident vocals make this track one of the best of the year.
16. “Sweet Nothing” – Calvin Harris ft. Florence Welch
Of course, a year of great music would be nothing without DJ Calvin Harris and his ever-popular string of female collaborations. Florence Welch’s collab with the DJ was one of the best, with her soaring voice meshing with Harris’ pounding beats like they were made for each other.
15. “Chasing the Sun” – The Wanted
In 2012 we also saw boy bands make a fast, unapologetic, hugely popular return. The Wanted were one of them and their hit “Chasing the Sun” still takes me back to the summer time and all the great memories I had.
14. “Starships” – Nicki Minaj
Who knew Nicki Minaj could sing? “Starships” was the first single off Minaj’s second album, with a poppier sound. Minaj cleverly incorporated dance and house elements to the track to keep up with the 2012 EDM trend.
13. “Every Single Night” – Fiona Apple
Fiona Apple’s “Every Single Night” was the perfect example of a track that could rely on minimal instrumentation, a great set of pipes, and thoughtful lyrics to be successful. Apple clearly wrote the song from experience as she sang “every single night it’s a fight with my brain.”
12. “Locked Out of Heaven” – Bruno Mars
Bruno Mars seemed to have found his calling as an artist mixing retro elements with modern hip-hop elements. “Locked Out of Heaven” showcased Mars’ smooth voice and set a record by topping three charts at the same time
11. “A Team” – Ed Sheeran
Ed Sheeran’s “A Team” is a haunting yet beautiful track about a girl’s addiction to cocaine. The dark lyrics, soft melody and Sheeran’s sweet voice are the perfect combination. It’s no wonder Sheeran received a Grammy nomination for this song.
10. “Swimming Pools” – Kendrick Lamar
Up and comer Kendrick Lamar made a name for himself with this smooth track about his relationship with liquor. Lamar’s mellow vibe and laidback style made this track one worth listening to.
9. “Anything Could Happen” – Ellie Goulding
Indie-pop darling Ellie Goulding had quite the year, despite breaking up with producer-boyfriend Skrillex. Her synth-drenched single “Anything Could Happen” was one of her better tracks with a great beat and heart-breaking video to go with it.
8. “Climax” – Usher
Usher came back in 2012 to remind us that he can still serenade like a pro. Some of Usher’s best work comes in the form of slow jams and “Climax” was no exception. The R&B crooner made hearts melt everywhere with this ballad and his falsetto is still on point.
7. “Live While We’re Young – One Direction
Is a list of best songs really a list without British boy band hotties One Direction? Their upbeat summer track exploded as soon as it was leaked online and made girls everywhere swoon. Talk about a British invasion!
6. “Take a Walk” – Passion Pit
Passion Pit’s “Take a Walk” had a completely different vibe from the indie band’s previous work, which was more atmospheric. “Take a Walk” has a stomping beat, coherent vocals, and a catchy chorus impossible to shake.
5. “I Will Wait” – Mumford and Sons
Mumford and Sons pretty much created their own genre of sound, mixing folk and rock, and incorporating gruff but beautiful harmonies. “I Will Wait” has their signature banjo-y style with sweet lyrics that will make you fall in love.
4. “Some Nights” – Fun.
A follow up to their incredible hit “We Are Young,” “Some Nights” is Fun.’s latest and greatest. The clean harmony is just perfect and the almost militaristic beat make this track fresh in a world of cloned pop music.
3. “We Are Never Ever Getting Back Together” – Taylor Swift
Taylor Swift has now officially perfected the art of the breakup song. “We Are Never Ever Getting Back Together” not only had flawlessly blunt lyrics, but a melody that just made you want to get up and dance. Perfect for any girl trying to get over her latest boy.
2. “Gangnam Style” – Psy
You’ve gotta hand it to Psy. His song wasn’t even in English and it went from YouTube sensation to actually playing in clubs and on the radio to becoming one of the most popular tracks of the year. Any song that has an awesome dance to go with it like “Gangnam Style” is an A+ in my books!
1. “Call me Maybe” – Carly Rae Jepsen
Is it really any contest? Carly Rae Jepsen went from a struggling artist to mega superstar before Justin Bieber and friends could even finish recording their hilarious YouTube video. The song is so catchy, love it or hate it, you’ve jammed to the track at one point. Kudos to Carly for creating the song of the year.

domain: entertainment


NNPC funded Buhari’s 2019 election with bribes from crude oil contracts: Bloomberg
President Mohammadu Buhari funded his campaign in 2019 with bribes paid to the Nigerian National Petroleum Corporation NNPC by British Petroleum, according to testimony from a court case filed in London.
At least $900,000 (N513 million) was paid as bribes to the state-run oil company for oil contracts that reportedly went to Mr Buhari’s reelection war chest, Bloomberg said.
The report said Jonathan Zarembok, a former BP West Africa chief, sued his former employer and alleged that he was fired for raising concerns over a large amount of money paid as bribes to middlemen in Nigeria to ease contract awards.
Mr Zarembok testified in a court filing released earlier this month. The report also cited internal BP emails in which officials discussed how their decision to make suspicious payments would be shaped by the 2019 elections, which was to get underway in 2018 when the primary season opened.
The company subsequently paid $900,000 in suspicious funds to a local agent after securing two oil cargoes from NNPC, Bloomberg reported.
“BP is defending in full and denies all allegations made by the claimant,” the company said in a statement without expanding on the specifics of Mr Zarembok’s allegations.
Nigerian main political parties, the ruling All Progressives Congress and the opposition Peoples Democratic Party, have long faced charges of electoral fraud, including financing elections with money from state coffers without severe consequences.
Samson Makoji, a spokesman for NNPC, said that comments relating to bribery and corruption in the NNPC should be directed to the office of the new general manager of the corporation. A spokesman for the president did not return a request seeking comment.
We have recently deactivated our website's comment provider in favour of other channels of distribution and commentary. We encourage you to join the conversation on our stories via our Facebook, Twitter and other social media pages.
More from Peoples Gazette
“Katsina State is Atiku’s political base because it is his second home.”
The police recovered electrical distribution boxes, rolls of cables, and many quantities of LED electrical bulbs, all valued at about ₦1,500,000, from the notorious suspects.
AA and ADP have urged President Bola Tinubu and Nigerians to renew their commitment to shared values and nation-building.
The UK has suspended the Global Tariff for cut flowers to increase trade and provide better value for consumers.
Ten years after Chibok girls’ mass abduction, Nigerian schoolchildren still at risk: Human Rights Watch
During February and March 2024 alone, bandits kidnapped over 200 children from their schools in Kaduna and Sokoto.


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Crazy Facts About The Rajapaksas, Sri Lanka's Most Powerful Family, Now On The Run
Gotabaya Rajapaksa was forced to run away from the country and resign as president, Mahinda was forced to step down as Prime Minister, and Basil was stopped by airport staff from fleeing to Dubai - these are some of the things that Sri Lanka's most powerful political family had to go through recently - something that was unimaginable in the country until recently.
That is because the Rajapaksas enjoyed an almost superhero image among the Sri Lankan population for their role in ending the 26-year-old Tamil separatist insurgency in 2009 when Mahinda was the president, Gotabaya the Defence Secretary, Basil, Minister of Economic Development, and Chamal the Speaker of Parliament.
Here are some facts about the Rajapaksa family
The Rajapaksa brothers are the children of Don Alwin Rajapaksa, a Sri Lankan politician and freedom fighter and a founding member of the Sri Lanka Freedom Party. Apart from their political connections, the family made their fortune from coconut, rice, and rubber cultivation.
The second generation enters national politics
Unlike their father whose political influence was limited to their hometown of Hambantota, the second generation had national ambitions.
Mahinda, the fourth of the nine siblings was the first to make it to national politics. In 2005 he became the President of Sri Lanka and continued in power till 2015.
He also appointed his eldest brother Chamal as the Parliament speaker, Gotabaya as Defence Secretary, and Basil as Finance Minister.
Gotabaya - from Army to minister and President
Gotabaya began his career with the Sri Lankan army in 1971 and retired as Lieutenant Colonel in 1991.
He later migrated to the US and returned to Sri Lanka in 2005 to assist his brother Mahinda in his Presidential election. Following Mahinda's win, Gotabaya was made the Defence Secretary.
He played a key role in crushing the LTTE and was popularly called 'The Terminator.
He resigned from his post in 2015 following Mahinda's defeat in the election and in 2019 became the president of Sri Lanka.
In 2019 when Gotabaya was running for the office of the President, one of the biggest allegations he had to face was about his citizenship. Gotabaya who migrated to the US in the 90s had become a naturalised US Citizen and even had an American passport.
He gave up his American citizenship ahead of the 2019 elections because of a law that barred foreign nationals from running for the presidency.
Superstition runs in the family
When Mahinda was the president, one of the most powerful men in the country was his astrologer Sumanadasa Abeygunawardena. It is said that Mahinda took all key decisions after consulting his astrologer.
But that proved costly to him in 2014 after he declared a snap general election on the advice of Abeygunawardena who predicted a huge victory for Rajapaksa.
When the election result was declared in January 2015, Rajapaksa lost to his former Health Minister Maitripla Sirisena.
Even Gotabaya had his own set of astrologers and it is widely believed that he had announced in advance to resign on July 13 for astrological reasons. July 13 was a full moon day and is considered auspicious in Buddhism.
It is all about Hambantota
The Rajapaksas did not forget their roots and showered the nation's resources on their hometown Hambantota.
This includes the Hambantota Port and an Airport that was funded and constructed by the Chinese.
The Mattala Rajapaksa International Airport in Hambantota is a classic case of the abuse of power by the Rajapaksas.
It is dubbed as the world's emptiest airport as rarely any flights land there. It is alleged that the airport was built only for the reason that Rajapaksa wanted a grand airport in his hometown.
For more on news, sports, and current affairs from around the world, please visit Indiatimes News.


Here are a few vocal renditions of songs that are usually delivered instrumentally.
Margie Singleton - Magic Star (Tel-Star) (1:47) - Believe it or not, Bobby Rydell also cut a vocal version of this one.
Sonny James - Apache (2:37) - For the unadulterated story of Apache and all its cultural implications go check out the amazing write-up posted on Soul Sides a couple of years back. The one Apache wrinkle that goes unexplored there, though, is the lyrical approach taken by Sonny James on this 1961 RCA release.
Bill Doggett (with vocal by Tommy Brown) - Honky Tonk (2:25) - Tommy Brown was a major player on the R&B scene in Atlanta in the early 1950s, right alongside legends like Little Richard and Billy Wright. Angel Baby and Dick Blackburn did a mighty fine interview with vocalist Brown for a Lost In Paradise podcast, which you can listen to over here.


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Keyword Analysis & Research: cabq gov pets dogs
Keyword Research: People who searched cabq gov pets dogs also searched
Search Results related to cabq gov pets dogs on Search Engine
Changes to Animal Welfare Department Daily Operations ...
Animal Welfare will accept non-emergency stray pets at each shelter location seven days a week from 9:30 a.m. to 5 p.m. by appointment only. Use the link below to schedule an appointment. Finders of healthy stray pets are being asked to maintain custody of the pet until their appointment and look for its owner, as allowed per the HEART Ordinance.
DA: 17 PA: 97 MOZ Rank: 12
Pet Adoption — City of Albuquerque
AWD is waiving fees for all adoptions of available pets in care and in foster homes thru the Fall of 2021. Search for an Adoptable Pet. Adoption Fees. Adoption Locations: Eastside Shelter, Westside Shelter and Lucky Paws Adoption Center. Dogs. $25 Dogs; Cats. $25 Cats
DA: 24 PA: 100 MOZ Rank: 66
Albuquerque Animal Services - Eastside in Albuquerque, New ...
Yet animal shelters are filled with dogs and cats who must find homes. So rather than buying a dog or puppy for sale from a dog breeder or buying a cat or kitten for sale from a cat breeder, we encourage people to adopt a dog, adopt a cat, adopt a puppy or adopt a kitten at their local animal shelter, SPCA, humane society or pet rescue group.
DA: 63 PA: 100 MOZ Rank: 72
Albuquerque A-Z — City of Albuquerque
311 COMMUNITY CONTACT CENTER. The 311 Community Contact Center is a centralized call center for the City of Albuquerque. The 311 service is a single telephone number for all non-emergency City of Albuquerque inquiries and services.
DA: 84 PA: 15 MOZ Rank: 21
City officials to announce plans for summer events
*Correction issued below ALBUQUERQUE, N.M. (KRQE) – City officials announced their plans for Fourth of July fireworks and other various summer events Thursday. Fireworks will return to Balloon…
DA: 52 PA: 70 MOZ Rank: 80
Meeting to be held on Gateway Center - KRQE
ALBUQUERQUE, N.M. (KRQE) – The city is holding a public meeting on the city’s planned 24/7 homeless shelter. The city is transforming the Gibson Medical Center into the Gateway Center. T…
DA: 24 PA: 42 MOZ Rank: 95
Editorial: Need a forever pal? Help Empty the Shelter ...
Dogs come with one free dog training class. To deal with the fireworks Keeping pets calm as bombs are bursting in air is a tough challenge, but don’t let it deter you from finding that new ...
DA: 92 PA: 84 MOZ Rank: 81

domain: pet


text:
Happy Birthday, Elvis!
Elvis died not long after I was born but I grew up listening to him and the Beatles. I thought about him over the holidays because I had a few of his Christmas songs on my holiday playlist. When I saw on the whacky holiday calendar that it was his birthday, I decided we’d have to celebrate it for a bit of nostalgia. One of his favorite dishes was banana pudding. Coincidentally, it is also one of Jeff’s favorites. It’s comfort food for many a Southern boy.
Add some vanilla wafers, which I use as sugar cookie dough at Christmas, and some whipped cream made out of coconut milk and you can celebrate, too. To make vanilla wafers, roll the cookie dough into balls and flatten between your palms before baking.
As always, these recipes are from the Menu Mailer. Please consider a subscription or a small purchase to help support this blog and the free content.
From the Menu Mailer
3 egg yolks, beaten
¼ cup rapadura
1 Tbs cornstarch or arrowroot
1/8 tsp salt
1½ cups coconut milk or dairy milk
1 Tbs coconut oil or butter
½ tsp vanilla extract
1-2 bananas, sliced
Beat the yolks in a small bowl and set aside.
In a saucepan, combine the rapadura, cornstarch and salt. Whisk in the milk until smooth. Place over medium heat and bring to a boil, whisking occasionally. Boil while whisking for 2 minutes. Take a ½ cup of the mixture and ladle it into the bowl with the egg yolks while whisking constantly. Whisk until well combined, then whisk the yolk mixture into the saucepan. Whisk until thickened. Remove from the heat and whisk in the fat until melted and the vanilla. Pour into a bowl and refrigerate until cold, at least 2 hours. Gently fold in the sliced bananas just before serving.
[boilerplate plate = “sig” search = “replace” usequery=”anything”]
Sarah @ Mum In Bloom says
Yum yum my kids would LOVE this! I’ve never made banana pudding and this would be a real treat 🙂
Sarah @ Mum In Bloom recently posted..Peanut Butter-Granola Balls
Holly E says
I LOVE banana pudding!! I cannot wait to give this a try.
Sandra Lee says
help, how do I STOP receiving email updates from your website
every time there’s a new comment on the blog entry
“Giveaway: One year menu mailer package”???
I must have put a check or click on the wrong button.
I entered by commenting, but now I get an email for everyone’s comment after mine.
KerryAnn Foster says
Sanda, I suspended it. You shouldn’t get any more. Sorry for the trouble.
I like this banana pudding ..Thank you for sharing the recipe..I am going to make this on weekend..
Sheila recently posted..Happy New Year To All Of You And Hope You Like The Aquarium Fish Photos Here …

domain: food


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The outbreak of the COVID-19 pandemic has redefined conventional forms of social interactions and slowed down the global economy at large. A number of countries, across the world, continue to enforce lockdown and quarantine...KEEP READING
The CPD Blog is intended to stimulate dialog among scholars and practitioners from around the world in the public diplomacy sphere. The opinions represented here are the authors' own and do not necessarily reflect CPD's views. For blogger guidelines, click here.
The Arts of International Affairs: Time for a New Conversation about Culture
Once again the debate about the arts and their relationship to the economy has been enjoined, this time in the UK. The terms are by now entirely familiar, and certainly loom in any discussion of the “value” of the arts in the U.S. as well. This is particularly true for the U.S. during recessions and periods of fiscal austerity. The NEA, as we know, is frequently obliged to make the case for the arts as a contributor to national economic growth. And it has been a virtual cottage industry among a succession of arts advocacy groups also desperate to do the same.
On one side of this broken record are found often highly instrumental and entrepreneurial accounts of the surplus value of investment in the arts: efforts to relate the creative sector to the overall performance of the economy, new models for understanding artistic creativity as a catalyst for economic innovation or cultural hubs as keys to urban renewal, and new tools to measure the economic contributions of the arts. These pitches appear most often designed for skeptical legislators and business leaders, city mayors and urban developers, who apparently feel the arts to be either an engine of capital or frivolous.
Inevitably, on the other side are artists and arts advocates whose first impulse is to defend the sanctity of “art for art’s sake” – still – often against the perceived cynical motives behind any effort to “quantify creativity” and undermine artistic integrity, which, in this, our post-“age of mechanical reproduction,” threatens to turn works of art into monochromatic commodities or economic goods. In passionate defense of their calling, artists tend to represent the value of art as universal, defended, alternatively, as an essentially spiritual, expressive, or creative exercise in what it means to be human. Given this, artists are often disinclined to justify or explore the various uses or value of art. Art just is.
If apparently a debate without end, the terms of this debate are also notably parochial. It is no coincidence that this public policy argument about the arts is especially characteristic of the U.S. and the UK, and countries with similarly relatively scant public funding for the arts, significantly privatized arts economies, where artistic products are a major export, and most notably, where the public meaning of “art” is a legacy of Enlightenment-derived aesthetic and moral concepts.
In other words, the tendency to separate “art” (as a universalizing aesthetic aspiration) from “culture” (as a localized expression of a particular people), to treat art as the unique product of individual creation, to prioritize and formally evaluate aesthetic significance, and the perceived clash between aesthetic and utilitarian goals (or art and money), are, together, a fairly specific conception of things. These several commitments participate – as basic cultural underpinnings – in constituting the overlapping art worlds of the U.S. and UK. But these art worlds are not at the same time the world’s.
A brief international comparison makes the point. In the U.S. we often identify graffiti as not art, as anonymous, popular, and criminal. In Mexico City graffiti has been described as a marginal genre, syncretically bridging artisanal with mass production, text and image, and manifesting urban disorder in the battle for control of public space. In pursuit of the “creative city” concept, Barcelona, Spain, has designated specific zones for graffiti artists to legally express themselves, as part of the promotion of a “context of freedom.” While in China, in contrast, graffiti has only recently appeared, as largely non-confrontational, expressing little political content, leaning more “towards fashion” in ways blurring the distinction with advertisements. As art or not art, criminal, insurgent, or fashionable, graffiti is not self-evident internationally, but a doorway into the cultural diversity of geopolitical arrangements of public and private globally.
There promises to be no resolution to the recurring debate between philistines and free spirits over whether to give art over to the “language of business” to secure its financial future on the one hand, or to strip it of all utilitarian conceits , on the other, in “the exploration of truth and beauty.” This is the case, even as successive “arts in/for the economy” paradigms underwhelm while puritanical defenders of artistic integrity talk largely among themselves.
A cursory survey of corporate and foundation funding for “the arts and culture” reveals modest spending to support arts groups, concert series, shows, exhibitions and performances in the U.S., that is, artists directly enriching the civic life of communities. But, in international terms, all of this misses the point. The slot allotted to art in U.S. public life is alarmingly narrow in scope and so self-referential as to be problematic, if we hope to engage the many cultural worlds of art globally.
With few exceptions, neither side spends much time: seriously working to bridge this agonistic divide, putting art and cultural production back into their different social contexts, considering the several ways art is meaningful for distinct local and global publics, or working to provide more grounded data to better understand art’s many effects. Some of these exceptions can be found here and here. But to understand the multifarious role of art in the international arena, and the ways it participates in such projects as cultural diplomacy, we should jettison the terms of our domestic discussion, since they actively undermine such inquiry.
A first step is to resist the convention to distinguish “art” from “culture,” which has served to cut off domestic arts policy in the U.S. and elsewhere from broader appreciation of the cultural challenges that cross cut international affairs. Especially for applied arts NGOs working with international counterparts. A second step is to recognize and interrogate our own assumptions about the purpose and value of “art.” A third is to re-inscribe “art” back into its encompassing local and transnational settings of social engagement and meaning. A fourth is to take more seriously others’ conceptions of art, as a complex cultural expression.
Finally, we should be much more attentive to the diverse ways in which cultural expression – including artistic production – is entangled in international affairs at present. The list is getting longer, but most obviously includes culture conceived as: rights, property, digital information content, heritage, security, local and national identity, as well as goods and services. It further includes the ways culture is mobilized and accounted for in: diplomacy, humanitarian response, international development, democratizing movements, and exclusionary politics. These are big challenges. “Art” is one mode through which international affairs are culturally configured. Let’s start treating it that way.
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Public Diplomacy in the News: A History of State Dinners, Eurovision Boycott, and L.A.’s Olympic Angst


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Monday, 28 November 2016
Sew Together Bag in Liberty
My EPP Liberty Sew Together Bag is finished, ready to be filled with all the bits and pieces I need for more EPP projects. The lining and pockets are from various Art Gallery fabric collections, and I have attached a lovely piece of hand dyed wool felt for a needle rest. I had Liberty binding left over from the binding I used on my Bloomsbury Quilt (yes I have finished binding it, just more quilting required) so opted to use that on the bag, rather than faffing around making up more.
This bag was not without it's making dramas. The zips were unpicked a few times, due to not reading the instructions about lining/pocket placement. I was tempted to give up at one point, but am now quite pleased with how this has turned out and am now dreaming up a new EPP project for the summer holidays.


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Wine Coolers are a classic, and easy to drink party option! Learn more today!
It was during the 1980s that brands like Seagram’s and California Cooler made names for themselves. The production of wine paired with other flavors into fruity concoctions resulted in crisp and refreshing beverages that were perfect for parties on hot summer nights. They were all the rage back then, with over 10% of all wine sales in 1985 being wine cooler sales.
There is still a lot of love for these sensational carbonated beverages in the 21st century. Those who aren’t fond of beer can still sip on something that fits their preference. The sheer variety of flavors is appealing to many, especially those with a love of switching things up. Though people still love wine coolers, the average consumer doesn’t know much about what these concoctions are or how they’re made.
How are Wine Coolers Made?
Traditionally, a wine cooler consists of wine and various other ingredients to create a new flavor. This traces back to the use of apple wine, though other wines play a role in the creation of wine coolers ever since. Think of Sangria, which has wine, sugars, and fruit. This is a very easy and very popular homemade wine cooler to make, though it is available in retail establishments too.
However, many retailers have chosen to take a different approach to their wine coolers – by eliminating the wine content entirely. Drinks that used to consist of a dry, white wine are often now made with a malt alcohol base instead. For instance, Zima (which has resurged onto shelves recently) is a malt-based wine cooler, so it’s not really a wine cooler at all. For the sake of accuracy, perhaps these drinks are “beer coolers.” It is not uncommon to call these drinks “malternative” beverages rather than wine coolers.
Try these Amazing Summer Red Wine Cocktails!
Seagram’s Wild Berries contains 37 grams of sugar, as an example, per 150-calorie bottle.
The Vancouver International Wine Festival is an amazing celebration and display of the worlds best wines!
Wine stains. We've all been there. Learn how to remove, and deal with this unnecessary evil!
Selecting the right wine does not have to be a difficult process. Asking the right questions leads to the right answers.
When buying wines, there are many factors to think about. These Wine Shop Tips will give you the upper hand.
You may think that you are not in a good wine shop based on its appearance. However, flipping some bottles will help you figure out how reliable their products are. If you see names such as Kermit Lynch, you can thank your lucky stars as you are in good hands. In such a case, you can freely choose from the selections, and you are sure to enjoy the product.
Pay Attention To Labels & Packaging
Most good wines come in 750 ml packaging with little aesthetic improvements. Thus, if you see a wine packaged in sparkly, ostentatious labels, be sure to stay away. The chances are high that the product does not match the labeling and you will be disappointed.
While it is true that there are cheap wines in the USA, it is quite hard to find them. Thus, you are better off looking for affordable wines from other regions in the world. Take an example of Chile and France. With about thirteen dollars in hand, you can get a high-quality wine.
It is quite easy to enter a store, grab a bottle, check out and head out without much thought. However, it is more rewarding to spend more time in the selection. It not only allows you to get the most delicious wine but also saves you some money.
In the case of a quality wine shop, talking to the experts around is quite helpful. The first thing you want to get out of the way is how much you wish to spend. Given that the attendants cannot read your mind, it is best to get them on the same page. Whether you are looking for a wine costing 10 dollars or 30, they will get something for you. It also helps them narrow down their selections to those within your range. The word affordable does not cut it, and you do need to be specific regarding your budget.
Suppose you wish to purchase a particular wine, there is an easy way to get it: a photo. When you show this photo to the attendees, they can handle it in many ways. If they lack the given brand, they will look into other wines by that winery. They can also get you wines of the same grape variety or region. In this way, you can sample something quite similar to your choice. You can additionally come up with a photo album which will further help the attendants in wine selections for you.
Think About Pairings
Most wines work for specific occasions, and you should have this in mind during selections. One way to zero in on your choices is to consider the meal you plan to serve alongside the wine. Suppose you plan on making lamb chops, the attendants will walk you through the cabernet sauvignon options available. Thus, you will avoid a situation where your wine does not pair well with the foods you love.
The last way in which you can successfully buy wine is to go to a renowned shop. Here, experts can guide you through their best red wine options as well as their best white wine varieties. You can also opt to purchase wine from online shops where they give extensive selections. Thus, the next time you are looking for the best red wine, you know what to do.

domain: hobby


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With only a small lead over Disney toon “Frozen,” Lionsgate’s “The Hunger Games: Catching Fire” is expected to win the Thanksgiving extended frame with upwards of $85 million.
The actioner earned $20.7 million Wednesday, bringing its domestic cume to $206.4 million in only six days. It is now the sixth fastest film to cross the $200 million mark after “The Avengers,” “The Dark Knight,” “Harry Potter and the Deathly Hallows: Part 2,” “Transformers: Revenge of the Fallen” and “The Dark Knight Rises” (“Rises” also took six days, but wound up with $211.8 million).
“Frozen” bowed Wednesday to $15.2 million and is expected to earn between $70 million and $80 million catering to families with young children this weekend. Though Thanksgiving Day isn’t generally a big moviegoing day, “Frozen” should see about 11% of its five-day haul from the holiday itself.
Other openers counterprogramming the weekend’s big bows are doing so with mixed success.
Open Road bowed »
- Michael Sullivan
Similar News ItemsThe Dark Knight Rises (2012)
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- Final trailer for The Expendables 3 (From Flickeringmyth. 31 July 2014, 2:24 PM, PDT)
- Mad Max: Fury Road Images Show Tom Hardy Giving Nicholas Hoult a Boost (From Collider.com. 31 July 2014, 8:06 AM, PDT)
The Dark Knight (2008)
- David Zayas joins Gotham as mob boss Sal Maroni (From Flickeringmyth. 1 August 2014, 2:46 PM, PDT)
- 5 Geeky Things We Want This Week, Batman's 75th Anniversary Edition (From GeekTyrant. 1 August 2014, 1:15 PM, PDT)
- David Zayas cast as mobster Sal Maroni in 'Gotham' (From EW.com - Inside TV. 1 August 2014, 11:45 AM, PDT)
The Hunger Games: Catching Fire (2013)
- Don’t Expect A Female Superhero Movie From Marvel Until At Least 2019 (From We Got This Covered. 1 August 2014, 5:52 PM, PDT)
- Jena Malone Strips Down to Her Skivvies at Lingerie Bash (From TooFab. 1 August 2014, 3:45 PM, PDT)
- New poster, clip, featurette and TV spots for Teenage Mutant Ninja Turtles (From Flickeringmyth. 1 August 2014, 1:08 AM, PDT)


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Applauding India’s recent decisions to pass the national bankruptcy law, release of National Intellectual Property Rights policy and several steps taken over the last two years on ease of doing business, Arun M Kumar, Director General, US and Foreign Commercial Service, and Assistant Secretary, Global Markets, US Department of Commerce called for tangible progress in India’s business climate along with harmonisation of product standards with international rules in order to enhance its position in the global supply chain.
“Many US companies are increasingly optimistic about the shift in tone, but are waiting to see further tangible progress in India’s business climate. Even as some states have moved swiftly up the rankings, India still ranks lowest among the G20 countries on the World Bank’s 2016 Doing Business report,” said Kumar.
Speaking at an even organised by Yes Bank in association with Indo-American Chamber of Commerce, Kumar said that India also needs to remove obstacles for companies to come and operate in India.
“To enhance its position in global supply chains and deepen its integration with the world economy, India will need to harmonise product standards with international rules. Standards barriers — such as certain testing, certification, and registration requirements — not only pose obstacles to US companies, but hamper the pace of India’s integration into the global economy,” he said.
Kumar, however, praised India’s decision to pass the bankruptcy law and release of NIPR policy, saying it said will foster innovation and will also centralise the copyright and patent regimes under DIPP and improve coordination between the center and states on compliance.
Kumar also took note of other economic reforms done by India such as — streamlining bureaucratic decision making; opening investment in railways, defense and e-commerce; step towards growing its civil nuclear market by ratifying the CSC in line with international rules on liability — and said that the American companies have responded to them and invested more in Indian equities than in China.
“Over the last two years, US businesses invested over $15 billion in India, and will reportedly sign deals worth another $27 billion over the next two years,” said Kumar.
He, however, pointed that India needs to a lot more in order to provide employment to nearly one-million people that come to Indian cities every month.
“India needs to further accelerate inward investment, which in turn will require additional measures to increase bilateral trade… High tariffs, localisation requirements, and other trade barriers and policies remain a significant challenge,” he said.
Speaking at the event, Banmali Agrawala, president and CEO of GE South Asia also highlighted the need to eliminate the inefficiencies in the system. Pointing that India needs to continue on what it has done over the last couple of years, Agrawala said, “Since it is government spending that is driving growth, the processes needs to be smoother, faster and predictable so that it results into clear action.”
Both Bhaskar Pramanik, chairman, Microsoft India, and Agrawala raised their concerns over the unpredictable taxation in India. “The retrospective tax has still not disappeared. Tax is a sword that hangs over our heads, suddenly the rules change and it is retrospective,” said Pramanik.
Agrawala also said that foreign investors need comfort on a predictable tax regime and pointed that if there is certainty, they will look to make India as a base for their global operations.


The Greater Orlando Aviation Authority wants to spend $1.2 billion during the next five years on new and renovation projects at Orlando International Airport.
The projects include:
• $470 million to expand the airport’s people mover system and a 3,500-space parking garage
• $114 million to upgrade Airside 4 to improve the flow of international traffic
• $90 million to upgrade the existing people mover system
• $18 million for a new cellphone waiting lot
• $120 million toward what will eventually be a $2.1 billion south terminal
The capital plan proposed by the airport was detailed in a fee package presented to the airport’s top 14 airlines June 13. The five-year agreement with top airlines — which includes Delta Air Lines, Southwest Airlines, American Airlines and JetBlue Airways — expires Sept. 30 and talks have broken down between the airlines and the aviation authority over extending it another five years.
Airlines have balked at a new agreement because of plans by the airport to build the $2.1 billion south terminal. The authority would begin seeking designs for the south terminal in 2017 and start construction on the project in 2018, according to the new fee agreement. It would take about four years to build the south terminal, which would have the new facility open in 2022.
“It’s a lot to absorb,” an airline executive who attended the meeting and did not want to be identified said of the new fee proposal.
The new agreement changes the way the airlines are charged for the airport’s space, baggage system, use of gates and parking, and it also leaves the airlines out of sharing revenue from the airport. Last year, the airlines received about $16 million from the airport.
“I think it can be viewed as an inducement,” Phil Brown, executive director of the airport authority, said of leaving the revenue sharing out of the agreement.
Airlines can be eligible for the revenue sharing if they agree to long-term agreements and not sue the authority over the new agreement.
“Some of them may be fine with this,” Brown said. “I’m certainly not in any position to predict how the airlines are going to react."
Airlines are going to have to study the new rates and determine how they are going to impact their operations, said an airline executive who attended the meeting and did not want to be identified.
Airlines are expected to comment on the new fee proposal and meet again with the authority in July.


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Key Study Points:
- Obese children and adolescents have several risk factors for cardiovascular disease including elevated blood pressure, cholesterol, fasting glucose and insulin, and an increase in left ventricular mass.
- These risk parameters of cardiovascular disease are greatest in obese children suggesting that they may also have a larger disease burden in adulthood if risk factors are not addressed early on.
Primer: The World Health Organization states that in 2010 more than 42 million children under the age of 5 were overweight with nearly 35 million of them living in developed nations. Hence, childhood obesity is one of the greatest health challenges of the 21st century. It has been well documented that adults who are overweight or obese are at an increased risk of cardiovascular disease, but the effects of childhood obesity and increased weight on the development of cardiovascular disease risk factors in childhood are not as well-delineated. In this study, a systematic review and meta-analysis were performed to examine the significance of the correlation between body mass index and risk factors of cardiovascular disease in children.
- Juhola J, et al. Tracking of serum lipid levels, blood pressure, and body mass index from childhood to adulthood: the Cardiovascular Risk in Young Finns Study. J Pediatr 2011;159:584-90.
- Kavey R et al. Expert panel on integrated guidelines for cardiovascular health and risk reduction in children and adolescents: summary report. Pediatrics 2011;S213-56.
- World Health Organization. Obesity and overweight factsheet number 311. www.who.int/mediacentre/factsheet/fs311/en/index.html
This [systematic review and meta-analysis]: The review and meta-analysis utilized of 63 studies that included a total of 49,220 healthy children aged 5-15 years of age from 42 highly developed countries. Both systolic and diastolic blood pressure measurements were markedly increased in overweight (4.54/2.57mg Hg) and obese (7.49/4.06 mg Hg) children when compared to normal weight children. Total cholesterol was significantly elevated in all obese children but not in overweight children. Also, HDL cholesterol was reduced in overweight (6.56 mg/dl) and obese children (8.48 mg/dl). In terms of fasting glucose, insulin, and insulin resistance, only obese children had significant increases in all of these parameters. Fasting insulin was found to be twice as high in obese versus normal weight children than in overweight versus normal weight children. Finally, obesity was also associated with an increase in height-adjusted left ventricular mass.
In sum: This study was a large multi-national meta-analysis that looked at the correlation between body mass index, sex, and risk factors of cardiovascular disease in children. The authors concluded that having an increased body mass index is associated with an increased likelihood of developing risk factors of cardiovascular disease. This would include increases in blood pressure, cholesterol, and fasting glucose and insulin. Without preventative measures, these findings would also potentially mark these children to have increased risk of cardiovascular risk as an adult with increased risk of cardiovascular disease, diabetes and stroke.
There were several limitations to the study. As a review and meta-analysis, there was a lack of standardization of methods across studies. Furthermore, the effect of age and pubertal status could not be tracked due to insufficient reporting from most studies. In addition, with a population drawn from developed nations, generalizability on the global scale remains to be seen and may require further study. Finally, while the authors argue that the implications of these findings may indeed be particularly important in tracking to adulthood, the analyzed studies did not specifically investigate this link. Nonetheless, in the setting of dramatic increases in childhood obesity, this meta-analysis speaks to the need of further research and better delineation of the relationship of BMI with associated cardiovascular risk, including the investigation of the effectiveness of interventions aimed at children with the objective of reducing morbidity and mortality in adulthood.
By BH and RR
© 2012 2minutemedicine.com. All rights reserved. No works may be reproduced without written consent from 2minutemedicine.com. DISCLAIMER: Posts are not medical advice and are not intended as such. Please see a healthcare professional if you seek medical advice.