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We report that NF-AT1 and NF-AT4 are expressed cytoplasmically in resting eosinophils, whereas NF-AT2 and NF-AT3 have not been seen. Likewise, NF-AT1 mRNA and NF-AT4 mRNA have been detected in resting eosinophils, and their levels can be significantly up-regulated by the Th2-associated cytokines IL-4 and IL-5. There is no detectable NF-AT protein expression in the nuclei of resting eosinophils. However NF-ATs appear in the nuclei of IL-4-, IL-5-, or ionomycin-stimulated eosinophils. Only NF-AT1 and NF-AT4, but not NF-AT2 and NF-AT3, have translocated into the nuclei in IL-4- or IL-5-stimulated eosinophils. These findings delineate a novel pathway in the cytokine network in which Th2 lymphocytes “control” eosinophils via the release of IL-4 and IL-5, and activation of NF-AT in eosinophils. The findings also suggest that a later feedback “talking” may exist between eosinophils and Th2 lymphocytes.
Nuclear factor of activated T cells is a family of transcription factors implicated in the control of cytokine and early immune response gene expression. NF-AT1-deficient mice are prone to developing a classically allergic phenotype characterized by eosinophilia and increased production of Th2-associated cytokines (1). Mice lacking NF-AT1 and NF-AT4 have allergic blepharitis, interstitial pneumonitis, and an increase in serum IgG1 and IgE levels, secondary to a selective increase in Th2-associated cytokines (2). NF-AT proteins are expressed not only in T lymphocytes but also in other cells including B lymphocytes, NK cells, mast cells, monocytes, thymus and spleen cells (3), and vascular smooth muscle cells (4). Thus far, it has not been determined whether NF-AT proteins are expressed in eosinophils. In the present study, we have investigated the expression of NF-AT proteins and the corresponding mRNA in peripheral eosinophils and the regulation of these proteins by IL-4 and IL-5.
Materials and Methods
Purification of eosinophils
Eosinophils were purified from healthy, nonallergic volunteers as described in detail elsewhere (5). Briefly, a Percoll gradient (1.082 g/ml; Pharmacia, Uppsala, Sweden) was used to enrich eosinophils; anti-CD16-coated MACS magnetic particles (Miltenyi Biotech, Bergisch Gladbach, Germany) were used to deplete neutrophils. Eosinophil purity was invariably ≥97% (lymphocytes <0.5%). The whole procedure was conducted at 4°C in a Ca2+-free and Mg2+-free medium.
The purified eosinophils were spun down on a slide, fixed, and immersed in 1% BSA blocking buffer for 10 min to avoid unspecific binding; next, primary Ab (20 μg/ml of either anti-NF-AT1 (mouse mAb 4G6-G5), anti-NF-AT2 (mouse mAb 7A6), anti-NF-AT3 (goat pAb3 C-20), or anti-NF-AT4 (goat pAb C-20); Santa Cruz Biotechnology, Santa Cruz, CA) was added. Eosinophils were then incubated overnight at 4°C, followed by the addition of secondary Ab, and were visualized by an alkaline phosphatase staining system (Dako, Glostrup, Denmark).
Real time quantitative RT-PCR assay
All real time quantitative RT-PCRs were performed as described elsewhere (6). Briefly, total RNA was reverse transcribed and submitted to real time quantitative PCR in an ABI Prism 7700 Sequence Detector System (Perkin-Elmer, Norwalk, CT). By using a SYBR Green PCR Core Reagents Kit (Perkin-Elmer), fluorescence signals were generated during each PCR cycle via the 5′ to 3′ endonuclease activity of AmpliTaq Gold to provide real time quantitative PCR information. The following sequences of the specific primers (Amersham Pharmacia Biotech, Little Chalfont, U.K.) were used: NF-AT1 sense, 5′-AGAAACTCGGCTCCAGAATCC-3′; NF-AT1 antisense, 5′-TGGTTGCCCTCATGTTGTTTTT-3′; NF-AT2 sense, 5′-GCCGCAGCACCCCTACCAGT-3′; NF-AT2 antisense, 5′-TTCTTCCTCCCGATGTCCGTCTCT-3′; NF-AT3 sense, 5′-GGTTTCCCGGCCAGTCCAGGTCTA-3′; NF-AT3 antisense, 5′-AAGGGGCGGGGAAGGAAGGAAACT-3′; NF-AT4 sense, 5′-ACCAGCCCGGGAGACTTCAATAGA-3′; NF-AT4 antisense, 5′-AAATACCTGCACAATCAATACTGG-3′.
The target cDNA was adjusted to amounts equal to those of the housekeeping gene (β-actin) according to the manufacturer’s instructions. PCRs were optimized under the following conditions: 15 s at 95°C and 60 s at 60°C with 40 cycles for each amplification. To express the results, two terms were used: ΔRn, representing the normalized reporter signal minus the baseline signal established in the first few cycles PCR, and CT (threshold cycle), representing the PCR cycle at which an increase in reporter fluorescence signal above a baseline can first be detected.
Electrophoretic mobility shift assay (EMSA)
Nuclear extracts were prepared as described by McCaffrey et al. and Aramburu et al. (7, 8). Briefly, 400 μl of ice-cold Dignam buffer A and then 25 μl of 10% Nonidet P-40 were added into the cells. The cells were vortexed and centrifuged (9000 rpm, 30 s, 4°C). Pelleted nuclei were lysed in 50 μl of Dignam buffer C and centrifuged (12,000 rpm, 10 min, 4°C); the resulting supernatants were diluted (1/1) with Dignam buffer D. Double-stranded synthetic oligonucleotide DNA probes were end-labeled with [γ-32P]ATP (5000 Ci/mmol) and T4 polynucleotide kinase (Amersham Pharmacia Biotech Inc.). The sequences of the oligonucleotide probes used (5′ to 3′, one strand) were as follows (9, 10): human IL-2 distal NF-AT site (NF-AT huIL-2), GGAGGAAAAACTGTTTCATACAGAAGG (binding sequences are underlined); consensus AP-1 site, CGCTTGATGACTCAGCCGGAA. EMSA reactions were performed at room temperature in a final volume of 25 μl. Nuclear extracts (3 μg of protein per reaction volume) were incubated for 15 min in binding buffer (8), followed by the addition of 0.5 ng 32P-labeled probes to react for 15 min; next, the samples were electrophoresed on nondenatured 5% polyacrylamide gels in 0.25 Tris-borate-EDTA (TBE) buffer. In some experiments, cold probes used as competitors were added at the beginning of the reaction to identical aliquots of the extracts (100-fold higher than labeled probes). The mAbs used for supershift (all at 10 μg/ml) were incubated with the nuclear extracts on ice for 30 min.
Results and Discussion
Expression of NF-AT in eosinophils
By immunocytochemistry assay, we have observed that NF-AT1 (Fig. 1,A) and NF-AT4 (Fig. 1,D) are cytoplasmically expressed in resting eosinophils. NF-AT2 (Fig. 1,B) and NF-AT3 (Fig. 1,C) have not been detected. Fig. 1, E and F, are the mouse and goat isotype Ab negative control, respectively. We have also observed a tendency for NF-AT1 and NF-AT4 to be expressed in the nuclei in IL-4- and IL-5-activated eosinophils. NF-ATs have also been detected in peripheral T lymphocytes (data not shown).
mRNA of the NF-AT family are expressed in eosinophils and regulated by IL-4 and IL-5
NF-AT1 and NF-AT4 mRNA have been detected in resting eosinophils; NF-AT2 and NF-AT3 mRNA have not (Fig. 2,A). There are ∼1.9 × 103 copies for NF-AT1 and ∼6.7 × 102 copies for NF-AT4 in the resting eosinophils, whereas no copies coding NF-AT2 and NF-AT3 have been found within 40 cycles. NF-AT1 mRNA have been significantly up-regulated in IL-4- and IL-5-stimulated (all at 10 ng/ml) eosinophils (Fig. 2,B). There are ∼6.4 × 103 copies and ∼5 × 103 copies for NF-AT1, respectively. NF-AT4 mRNA have also been significantly up-regulated in the IL-4- and IL-5-stimulated eosinophils (Fig. 2,C). There are ∼3.0 × 103 copies and ∼4.4 × 103 copies for NF-AT4, respectively. A linear relationship between CT and log starting quantity of the standard DNA template or target cDNA (NF-AT1 and NF-AT4) has been detected (Fig. 2 D). We have also observed that NF-AT1, NF-AT2, NF-AT3, and NF-AT4 have been expressed in purified T lymphocytes, and their expression can be up-regulated by IL-4 and IL-5, respectively (data not shown).
IL-4- and IL-5-induced activation of NF-AT in eosinophils
There is no detectable NF-AT in the nuclei of resting eosinophils. NF-AT huIL-2 binding proteins have been detected in the nuclei of IL-4- or IL-5-stimulated (1 h) eosinophils, which indicates that IL-4 and IL-5 can induce NF-AT activation, resulting a translocation of NF-AT in eosinophils (Fig. 3,A). Ionomycin (Ion) (0.1 μg/ml) also activates NF-AT to nuclear translocation. Cyclosporin A (0.1 μg/ml) is a potent inhibitor of activation of NF-AT (Fig. 3,A). NF-AT complexes in IL-4-, IL-5-, or Ion-stimulated eosinophils have been completely and specifically competed by a 100-fold molar excess of the cold NF-AT huIL-2 probe, whereas no competition is induced by the cold AP-1 site probe. A 100-fold molar excess of the cold AP-1 site probe can completely and specifically compete the 32P-labeled AP-1 probe (Fig. 3,B). It is not clear why the cold AP-1 site probe does not compete the NF-AT huIL-2 probe in our experiments, because the binding complex probably contains both NF-AT and AP-1 (8, 9). NF-AT translocation into the nuclei of IL-4- and IL-5-stimulated eosinophils has been detected within 15 min and lasts for ≥120 min (Fig. 4,A). In the current study, AP-1 was seen in freshly isolated eosinophils; increased activity of AP-1 in nuclei of eosinophils after stimulation with IL-4 or IL-5 was observed for 120 min (Fig. 4,B). NF-AT1 complex was supershifted by the mouse anti-NF-AT1 mAb (Fig. 4,C). Neither isotype mouse IgG nor mouse anti-NF-AT2 mAb can affect the relative mobility of the NF-AT complex. These results confirm the presence of NF-AT1, but not NF-AT2, in the nuclei of IL-4- or IL-5-activated eosinophils. Likewise, the presence of NF-AT4, but not NF-AT3, in the nuclei of IL-4- or IL-5-activated eosinophils has also been confirmed (data not shown). The mechanism by which IL-4 and IL-5 induce the appearance of NF-ATs in the nuclei of eosinophils is unknown, because the cytokines are not known to induce a Ca2+ influx, which is thought to be necessary for nuclear translocation of NF-AT. It will be of interest to further investigate this mechanism. In Fig. 4 C, it appears that the entire band is supershifted with anti-NF-AT1. This finding seems to be in contrast to the conclusions for NF-AT4. The reason for this phenomenon may be that the NF-AT4 content in eosinophils is so small that the NF-AT1 band overlaps the NF-AT4 band.
In mice lacking NF-AT1, resulting an in vivo model of allergic inflammation, an increased pleural accumulation of eosinophils and serum IgE levels and an abnormal pattern of IL-4 gene expression are seen (11, 12). The eosinophilia and high levels of serum IgE in these mice are apparently dependent upon the overproduction of IL-4 and IL-5 (1). Mice lacking NF-AT4 have impaired development of CD4 and CD8 single-positive thymocytes and peripheral T cells as well as hyperactivation of peripheral T cells (13). Our findings mentioned above suggest that the NF-AT family play a critical role in inducible gene transcription during the immune response, especially in the allergic response. Our results show that eosinophils, one of the key cells in allergic inflammation, may not only be a passive target for the deficiency, dysfunction, or inactivation of the NF-AT family in Th2 lymphocytes, but may also be an active regulator during the initiation, development, limitation, and termination of allergic inflammation.
Kiani et al. demonstrated that NF-AT1 is also involved in down-regulating the late phase of IL-4 gene transcription-inhibiting Th2 responses. This is evidence that NF-AT proteins regulate not only the initiation but also the termination of gene transcription (14). Our results are in support of this observation in light of the biological functions of eosinophils and Th2 lymphocytes. Based on our results, we might propose that NF-AT could be deficient or genetically inactivated in certain circumstances such as allergic conditions. A challenge such as allergen stimulation initiates a cascade of events of allergic inflammation, including overproduction of IL-4 and IL-5, activation of eosinophils, and eosinophilia. An over-release of IL-4 and IL-5 could subsequently activate NF-AT in eosinophils. The cascade of biological events in eosinophils after NF-AT activation would result in later feedback “talking” to Th2 lymphocytes to induce secondary activation of NF-AT in the Th2 lymphocytes (may also be other types of immune cells). This later feedback talking could lead to the termination of allergic disorders. A schematic view for this proposal is illustrated in Fig. 5. It will be quite interesting to investigate the exact mechanism of the secondary activation of NF-AT in Th2 lymphocytes during the later feedback talking on the pathway in the cytokine network between eosinophils and Th2 lymphocytes, especially in cells from allergic subjects.
We thank Lisbeth Abrahamsen and Ulla Minuva for their excellent technical assistance.
T.J., S.Q., and A.M. are supported by generous grants from the Danish Allergy Research Center and from the Alfred Benzons Foundation.
Abbreviations used in this paper: pAb, polyclonal Ab; EMSA, electrophoretic mobility shift assay; Ion, ionomycin; NF-AT huIL-2, distal NF-AT site of the human IL-2 promoter; CT, threshold cycle.


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Microsoft and its gaming arm, Xbox, made waves in the gaming world Thursday with the announcement that several exclusive Xbox games will soon be available on rival consoles.
Phil Spencer, Microsoft Gaming CEO, revealed in a special edition of the Official Xbox Podcast that four Xbox games will no longer be exclusive, opening up accessibility for players across different platforms.
While Spencer didn’t specify the titles or provide a precise timeline, he mentioned that two of the games would be community-driven and the other two would be smaller titles. He emphasized that the releases are imminent, suggesting that the move will make sense once they’re available.
Interestingly, Spencer clarified that this expansion of availability does not include Microsoft-owned Bethesda titles like Starfield and Indiana Jones.
Historically, gaming hardware manufacturers secure exclusive rights to popular games to incentivize consumers to purchase their consoles. However, Xbox’s decision to broaden accessibility indicates a shift in strategy.
Spencer highlighted the evolving landscape of gaming, predicting that exclusive titles will become less significant over the next five to ten years. This aligns with Microsoft’s overarching strategy, including the popular Game Pass subscription service, often likened to a Netflix for video games.
Microsoft’s Activision Blizzard Acquisition
Microsoft’s recent acquisition of video game giant Activision Blizzard further underscores its commitment to expanding gaming accessibility.
The announcement that Diablo IV will be available on Xbox Game Pass starting March 28 signifies the beginning of this expansion. Sarah Bond, Xbox President, emphasized the company’s dedication to making Xbox experiences and games widely accessible.
With the addition of Activision Blizzard’s blockbuster titles like Call of Duty and Overwatch, Xbox is poised for significant growth.
The impact of the Activision Blizzard acquisition is already evident in Microsoft’s financials, with substantial revenue growth in the fourth quarter of 2023. Xbox-related revenues surged by 61%, largely attributed to the addition of Activision Blizzard.
Despite regulatory hurdles and opposition, Microsoft completed the acquisition of Activision Blizzard for $69 billion in October. Throughout the process, Microsoft reiterated its commitment to expanding gaming accessibility rather than monopolizing popular titles, positioning itself as a driving force for change in the gaming industry.

domain: news


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I’m wracked with nerves and anxiety and electric shivering excitement.
I’m leaving on Thursday the 21st for the US. I’m going to be a part of New Visions | New Voices at the Kennedy Center in Washington DC. While I’m there I’m going to meet fellow writers from around the world, see brain expanding theatre, and hear my play – The Underground Library – done with American accents.
This is a favorite play of mine – a South African action/scifi about a young girl caught between an oppressive government and mysterious hacker group. (You can listen to it HERE.)
The problem is that I don’t have any funding and those randelas don’t go as far as they used to when buying dollars. The Kennedy Center is putting up accommodation but that’s all the support I can rely on at the moment.
So please give me money so I don’t come back so thin I’m transparent. And so I can maybe pay back my flights please. And so I can pay Maggie and Jamie to look after Alexander Upstairs while I’m away.
In the Kickstarter spirit I can make your generosity benefit you too. In August I’ll run two courses – one on Arts Marketing and Producing I developed while a Business Arts South Africa fellow and lecturer on Professional Practice at City Varsity, and one on Play writing that’s based on workshops I’ve done for schools and festivals. Doesn’t appeal? Something you’d like I can help with? Short play? Limerick? Poster? Putting up shelves? Carrying furniture? Let me know. I’m flexible and can reach high cupboards.
Email me at email@example.com for more details.
Thank you so much for reading,

domain: artistic


text:
|Maximum Weight Recommendation||200 Pounds|
|Maximum Speed||6 Miles per Hour|
About this item
- ✴ UL Safety Certification – Our self-balance hoverboards is UL2272 certified. The hover boards had tested and met the UL safety standard requirement. You can be worried free with the battery or charging issue and enjoy riding the electric board.
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domain: hobby


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Expense Receipt Template. It records the date, payment method, vendor, expense description, and payment amount. Replace a receipt that has disappeared long ago, create a receipt to impress your friends or make a receipt for goods/services that you sell.
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Why Keep An Expense Report?
_____ (name) _____ the amount You must set up applicable expense policies and rules, expense templates, and corporate card programs for the new country's. It is only reasonable that these expenses will have to be reimbursed by the company or institution that sent them on the trip, so you want to know what you’re paying for and whether this expense was necessary.
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Here are some of the best expense report templates for manual data entry: Along with this expenditure receipt, the detailed proof of the transaction made by the company is also attached, for example, a sales receipt. Once you’ve selected the receipt template you would like to use, you need to fill out receipt information (business name, transaction details, purchase cost).
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The month is broken down to separate days, easy coming with its own expense, savings, income and balance field for you to fill out. An employee sends an email with an expense receipt to a designated email address. Macy's department store receipt template.
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It comes with default settings (front types, font sizes). Expressexpense is a receipt maker that lets you create receipts for any purpose: Space is provided for advances and typical business trip categories;
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domain: finance


While some students spend Sunday night finishing homework, College freshmen Johnna Gadomski and Nora Keathley spent theirs finishing the 9.5-hour drive back to Emory’s campus from Washington, D.C. after they protested at the Women’s March on Washington.
“We decided to go to Washington because … we felt like after the election we’ve been so local … we need to be really proactive,” Keathley said. “We also liked the idea that women from all over, [all] corners of the country, [came] together in D.C.”
Gadomski and Keathley were among several Emory students and professors who participated in the Washington, D.C. march following the Friday presidential inauguration of Donald J. Trump. The Women’s March on Washington was part of a nationwide movement intended to show Trump’s administration that his stances on issues such as immigration and minority rights will be challenged. Other Emory community members remained closer to campus and marched in one of the sister marches, the Atlanta March for Women and Social Justice, in downtown Atlanta Jan. 21.
The protest application for the Women’s March on Washington, filed by multiple parties to the National Park Service, estimated that 200,000 people would arrive to protest. Organizers estimated that the actual turnout was 500,000 people, which resulted in some Emory marchers from Emory experiencing a two-hour delayed start.
Some demonstrators from Emory attended the march to protest Trump’s political rhetoric, which they said is authoritarian and targets minority groups.
Rollins School of Public Health Assistant Professor of Health Policy and Management Silke von Esenwein compared the new presidential administration to 1930s Germany. Von Esenwein said the march let Trump know that he must face the segments of the American population that are incompatible with his views.
Echoing the sentiments of von Esenwein, Oxford College Senior Lecturer in English Stacy Bell said she protested because she believes Trump is a criminal.
“He’s a rapist, he’s a misogynist, and a racist and a xenophobe,” she said.
Students like Gadomski attended the march to express their discontent with the new presidential administration and demonstrate their support for minority rights.
“This is us showing our government what matters to us, but the biggest step going forward is going to be turning our words and declarations into mobilized action,” Gadomski said. “Now more than ever we must fight for what we believe in and not leave it up to our government or anyone else for that matter.”


Have a model 12 savage. Stainless steel barrel, acu-trigger, wood stock (does have a scratch on bottom), and Leupold 3x9 scope. Around 80 rounds have been fired from it (used for hunting yotes). Got it this past year for christmas. Want an16" a3 upper, must be chrom lined barrel and chamber (Bushmaster, Colt, Stag, or RRA) and have a quad forearm rail . Would like the forearm to be samson, but not dead set on that. I don't have an FFL so buyer needs to have one or live in state (OH). If pics are wanted email me at Fausch.email@example.com.


Ontario’s Emissions Performance Standards (“EPS“) program began replacing the federal Output-Based Pricing System (“OBPS“) for greenhouse gas (“GHG“) emissions regulation on January 1, 2022. On October 22, 2021, Ontario amended two regulations under the Ontario Environmental Protection Act (“EPA“) in order to facilitate the transition: the Greenhouse Gas Emissions Performance Standards regulation (“EPS Regulation“) and the Greenhouse Gas Emissions: Quantification, Reporting and Verification regulation (“Reporting Regulation“) (collectively with EPS Regulation, the “Amendments“).
In addition to preventing Ontario industrial sites from being taxed twice for the same emissions under the EPS program and the OBPS, the Amendments were designed to ensure that there is no pricing gap for emissions during the transition period. Simply said, payment obligations under the OBPS will only be with respect to emissions up to December 31, 2021, even if reporting periods for both programs may overlap. Conversely, the EPS program’s payment responsibilities started on January 1, 2022.
Following the completion of all OBPS obligations for the 2021 compliance period, only the EPS program will continue to be applicable to sites in Ontario. Whether a facility is required to register with the EPS program depends on the nature of its industrial activities and its quantum of annual GHG emissions.
To comply with the EPS program and the related requirements, facilities are currently required to:
- submit a GHG report for the previous year;
- submit a verification statement and verification report regarding the GHG report;
- have the number of compliance instruments in their EPS account equal to their compliance obligation, if applicable; and
- if there is a shortfall, meet an additional compliance obligation.
December 15, 2022, is the regular-rate compensation deadline for the 2021 compliance period. Compensation provided after this date will be subject to the increased (4:1) compensation rate. As such it is essential for Ontario sites currently operating under OBPS, to transition to the EPS program before this deadline. Surplus credits issued to a facility in Ontario will not be eligible for remittance as compensation for the 2022 or subsequent compliance periods.
With the federal government’s increase in the benchmark compliance price under the Greenhouse Gas Pollution Pricing Act by $15/tonne per year, beginning in 2023 to reach $170 per tonne by 2030, it is anticipated that Ontario’s EPS program will increase in lock-step in order to maintain federal stringency requirements.


Michael Portillo has slammed "stupid" Tory MPs who think the Conservatives would have been able to push through a more radical programme of reforms had they shunned coalition with the Lib Dems.
The former Tory defence secretary said the coalition had in fact given David Cameron the political cover necessary to pursue an agenda almost as transformative as Margaret Thatcher's.
"Cameron is leading a government voted for by 60% of population, instigating austerity measures almost equivalent to Thatcher's," Portillo said. "Welfare reforms she would never have dreamt of, education reforms she would never have touched and health reforms she never touched."
"He would never have had permission from the media to do these reforms if he was leading a minority government," he told BBC's This Week programme on Thursday evening.
And he attacked the "stupid blinkered Tories" who think Cameron is constrained by leading a coalition. "Actually he has been liberated by coalition to do vastly more than he could ever achieve leading a minority."
Looking forward to the next election Portillo said "the Conservatives appear to be doomed" because no political party has increased its share of the vote while in government since 1955.
Several Tory MPs frequently blame the Lib Dems for blocking more radical Tory policies from being put in place, with some even calling for the coalition to be broken up immediately.
Backbencher Peter Bone has argued it is "not the prime minister’s fault but our Liberal Democrat partners that we are producing wishy-washy, irrelevant policies".
"A Conservative minority government with real Conservative policies would lead to people not resigning from the party but joining in droves," he said.


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Retro camera art
By James Grahame
Minneapolis artist Sean Tubridy has created a must-see collection of retro camera prints. Each signed print measures 5 x 5 inches on a 9 x 9 matte. His work also includes some clever t-shirts and vintage transistor radio work. While he doesn't have an online shop, you can order via email/PayPal (contact sales at blueoverblue dot com for all the deets).

domain: design


text:
Bryan Caraway Comments on Miesha Tate’s Retirement, Says Former Champ’s “Heart’s Not in it”
By FCF Staff
Miesha Tate shocked the MMA world this past weekend by announcing she’s retiring, but it sounds like her boyfriend Bryan Caraway wasn’t surprised by the move.
Tate lost via unanimous decision to Raquel Pennington at UFC 205, and afterwards, the former bantamweight champ announced “it’s not my time anymore”. Tate lost the title via first round submission to Amanda Nunes in July, after choking out Holly Holm this past March to become champion.
Following Tate’s announcement on Saturday, Caraway told Bloody Elbow.com the following:
“She’s not herself lately,” Caraway said. “She looked like that in the Nunes fight. She said it last night — her heart’s not in it anymore, so she didn’t care to try.”
The 30 year-old Tate finishes out her fighting career having gone 18-7.


Posted on November 24, 2020
When Bangladesh Inland Water Transport Authority (VISTA) started a dredging operation to remove silt from Barishal River Port around October 16, they expected it to be over by now. However, more than a month later, not even half of the works could be completed.
BIWTA officials said it’s the huge amount of polythene, plastic and other trash dumped into the water that is slowing down the project. As of yesterday, they have been recovering at least three maunds of junk every day.
“We set out to finish this as quickly as possible. The river needs to be dredged regularly for navigability’s sake, but we haven’t been able to dredg even half of our targeted 1.5 lakh cubic metres of silt,” BIWTA’s Assistant Engineer (Dredging) told this correspondent. “A lot of time and money is being wasted because of plastic pollution.”
After visiting the Barishal River Port and Kirtonkhola river area, it has been found that a huge amount of cloth, ropes, and plastic waste are coming up with the silt. After every 30-40 minute of operation, staffers take cloth, ropes, and plastic waste out of the dredging machines and keep them separately. This is done make disposal and recycling easier. Additionally, after every day, at least one submerged trawler is being collected from the river, the officials said.
The depth of the 40 km long Kirtankhola river is 100-150 feet in the middle side. During low tide, it stands at seven or feet around the port area, said sources within the department. However, launches get stuck on their way to the port if there isn’t at least 10-12 feet of depth. This means there’s no other way but to dredg the area of silt, and the polythene and plastic waste that comes with it.
Mostafizur Rahman, Joint Director of BIWTA and Barishal River Port Officer, said the operation will be carried out across 30 points on the Dhaka-Barishal route, including a few points at the port area. Dredging work is going on with two machines, he told this correspondent. “If everyone is not aware, the river port will start resembling the Buri Ganga river.”
Siddiqur Rahaman is a regular at the port. He collects revenues related to goods-transportation at the port. “I’ve seen launch passengers and staffers indiscriminately dump waste into the river. That’s at least 8-10 vehicles everyday.”
“Relevant authorities used to monitor the area and keep waste dumping under control, but after the early days of the pandemic, the monitoring has slackened,” he added.
“Although dumping garbage into the river is banned, some people are violating it and creating this problem,” said Saidur Rahman Rintu, Vice president of the Barisal Launch Owners Association. In the last two weeks, two launches got stuck near the port due to siltation, he informed.
This is a cause for alarm for citizens of Barishal, environmentalists, and government officials alike. Rafiqul Alam, Divisional Coordinator Bangladesh Paribesh Andolon (Bapa), said the accumulating waste has become a threat to navigability of the river port area, and the situation will only get worse if steps aren’t taken immediately.
Md Kamruzzaman Sarkar, acting director of the Environment Department, Barishal Divisional Office, said, “The problem is not just a local problem, it has spread to every region. If everyone were more aware and responsible, all of this could’ve been avoided.”


Threatened birds such as skylarks and curlews, as well as species such as nightjars, willow warblers, oystercatchers and little terns nest on the ground in moors, moors, woodlands, grasslands, beaches and coastal areas.
The Wildlife Trusts’ call to keep dogs on leads to protect fragile nests and eggs was backed by James Brittain-McVey, lead guitarist for The Vamps, dog owner and ambassador for the Coalition of Wildlife Charities.
He said: “I have learned as a rescue dog owner the importance of keeping your dog under control at all times.
“And at this time of year, it’s especially important to remember that we can all play our part in helping birds breed successfully by keeping dogs on short leashes in wild places, especially when so many species are going through such a difficult time.”
James Byrne, Landscape Recovery Program Manager for The Wildlife Trusts, said: “Allowing dogs to run wild in nature reserves can be devastating to wildlife, particularly in spring when species are breeding and vulnerable.
‘Heartbroken’ friends of 31-year-old Richard Dentith pay tribute after his stabbing death…
“We ask dog walkers to be sensitive by keeping their pets on short leashes, staying on paths and disposing of dog waste properly.
“Wildlife is already under enormous pressure – let’s keep all dogs under control so we don’t make matters worse.”
Nests and young on the ground may be at risk of disturbance, trampling or other damage.
Keeping dogs under control can also protect wildlife, from snakes to seals, as well as livestock like sheep.
Dogs disturbed seals at the Cumbria Wildlife Trust’s South Walney nature reserves earlier this year and the charity fears seal numbers are down.
Other wildlife trusts have encountered problems with dogs chasing grazing cattle, with several sheep recently attacked at a nature reserve run by Gwent Wildlife Trust in South Wales.
The Wildlife Trusts stresses that dogs must be kept on a leash of no more than two meters between March 1 and July 31 on open access land to protect ground-nesting birds.
And some beaches have cordoned off areas to protect some of the rarest bird nests – but charities say it’s best to keep dogs on a leash on all beaches and in the wider countryside until the chicks have fledged in September.
Some trusts also ask dog walkers to avoid some of their nature reserves because the wildlife there is too rare or fragile and requires special protection. Visitors should therefore check an individual reserve’s website before visiting for the first time.
The trusts also said dogs should be leashed around grazing animals, although it’s safer to leave your dog off-leash if you’re being chased by cows or horses.


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Ten U.S. medical institutions have just introduced the first accredited residency programs in addiction medicine. Doctors who have completed medical school and a primary residency will be able to spend a year studying the relationship between addiction, heredity, and brain chemistry.
The new accreditation is the result of work by the American Board of Addiction Medicine (ABAM), which ensures that addiction medicine physicians have the knowledge and skills to prevent, recognize, and treat addiction. Founded in 2007, ABAM certifies addiction medicine physicians across a range of medical specialties. The board sets standards for physician education, assesses physicians’ knowledge, and requires and tracks life-long education. ABAM expects to accredit an additional 10 to 15 residency programs this year.
Each institution has developed its own curriculum, although all residents, regardless of their institution, will learn to recognize and diagnose substance abuse, conduct brief interventions that spell out the treatment options, and prescribe the proper medications. The doctors also will be expected to understand the legal and practical implications of substance abuse. For more information about the new U.S. addiction residency programs, visit ABAM.
Although ABAM certification is open only to licensed physicians from the United States, U.S. Territories, and Canada, physicians from other countries may become certified as addiction specialists through the International Society of Addiction Medicine (ISAM) exam, which is open to graduates of any medical school recognized by the World Health Organization. For more information about the ISAM exam, visit the ISAM Web site.

domain: medical


text:
Both are good choices. And just remember that receiving a gift is just a sign of someone's care or appreciation for you.
Somebody get him s roll of bubble wrap.
Nice selection there.
Scroll Down to Read Other Opinions
Rooting for that ring! Hey boyfriend... put a ring on it!
Hahaha thanks for the support :)
Boyfriend better get on that... anytime baking presents are involved means baked goods for him! Lol
Hmm anyone got a little extra cash flow for this lovely lady?
Hahaha Oh, I wish. But I'll get there, hopefully next year.
You got this!
Thanks! I hope so. :)
Wishing that for you big time! Always a message away if you ever need to talk.
Nothing wrong with a little Nintendo love for the holidays!
While I love that lens... the f1.4 has been more stable in its usm function than the f1.2L and still produces an insanely beautiful image
But I do love a good L series lens... I have a couple myself and such a high quality product
Heard only good things about the F1.4.Though I'd never kick the canon F1.4 off my list, i already have a Minolta MD F1.4. And it's a god damn beauty. That's why I'm more interested in the F1.2.
Definitely don't... I have the f1.4. And its worth every penny on my 90D. Definitely a great substitute for the f1.2L considering the price points.
Very much down with that!
For me? Just want their to be a day of peace on our world where everyone can stop fighting for stupid crap and maybe start fighting for each other
Agree. I hope you have a good one
I hope yours is amazing and you get everything you want.
Ummmm... yes please!
That's okay too. Sometimes that is the case.
Someone please get this lovely lady a puppy!
I've been bothering my mom about sending me some for the longest, lol
Someone get this girl some buckeyes!
They will understand it sooner or later but we can definitely hope for sooner.


text:
NEW YORK (Reuters) - Police dismantled a heroin mill on the edge of Manhattan’s theater district two blocks from Times Square, shocking officials who did not expect to find such an operation near the bustling tourist attraction.
Four people were arrested and an estimated 13 kg (28 pounds) of heroin worth $6.5 million were seized on Wednesday night, the U.S. Drug Enforcement Administration said on Thursday.
“If our investigators were surprised by the location, you can only imagine the shock of neighbors, commuters and theater goers when they learned of the huge criminal enterprise operating inside,” Bridget Brennan, New York City’s special narcotics prosecutor, said in a statement.
A task force of the Drug Enforcement Administration (DEA), the New York Police Department and New York State Police led the operation on Wednesday night in a newly renovated, $3,800 a month apartment on West 43rd Street between 9th and 10th avenues — a short walk from Broadway theaters.
“This seizure is the result of superb investigative work that led to the discovery of a booming heroin mill in a completely unexpected location,” Brennan said.
As recently as the early 1990s the Times Square area was a haven for vice but intense police enforcement has turned it into a safe tourist attraction.
The apartment was used to convert bricks of heroin into small doses for sale on the street.
More than 250,000 glassine envelopes were found in the apartment, each of which sells for at least $10 on the street, Brennan’s statement said.
One of the suspects was arrested as he attempted to drive away from the apartment building in a car with a bag which contained refuse from heroin production. Another suspect was arrested inside the apartment, and two others were found after attempting to escape through a back door.
Many of the envelopes were marked with the brand names “King Kong” and “95 South,” two of at least 50 heroin brand name stamps found in the apartment.
The four suspects, ranging in age from 34 to 50, were expected to be arraigned on Thursday at Manhattan Criminal Court on charges of criminal possession of a controlled substance.
Reporting by Bernd Debusmann Jr.; Editing by Daniel Trotta

domain: law


Florida Health Regulators Announce Telemedicine Board Appointments
Florida’s health regulators announced the appointment of 13 health care professionals to a board tasked with assessing the viability of telemedicine.
The taskforce will recommend solutions for reimbursing doctors who use distance medicine technology to treat patients.
The 15-member panel will be chaired by Agency for Health Care Administration Secretary Elizabeth Dudek or her stand-in. Florida Surgeon General Celeste Philip was also appointed to the committee and can also select a stand-in.
The Telehealth Advisory Council was set up after lawmakers couldn't agree on the best way to regulate the use of webcams and other technology to treat patients from a distance.
Major sticking points were whether out-of-state doctors could participate and how physicians would be reimbursed for the services by insurance companies.
After years of failing bills, lawmakers decided on creating a taskforce to study these questions and make recommendations to the Legislature. The board is expected to have those recommendations a year from January.
The panel is composed of doctors, insurance representatives and medical supply executives from around the state, including Jacksonville Dr. Servam Terkonda.
A full list of the board appointees is below:
- Elizabeth Miller, CRNP, of Tampa, serves as the chief operation officer of WellCare Health Plans.
- Dr. Ernest Bertha, of Sunrise, serves as the medical director of Sunshine Health.
- William Manzie, of Hollywood, serves as the administrative director of Telehealth Strategy for Memorial Healthcare.
- Matthew Stanton, of Cleveland, serves as senior director of distance health for the Cleveland Clinic.
- Dr. Steven Selznick, of Longwood, serves as the CEO/president for Selznick Consulting.
- Darren Hay, of Miami Beach, serves as the senior vice president of Ideal Life.
- Monica Stynchula, of St. Petersburg, serves as the CEO of REUNIONCare and is the acting state president of AARP.
- Leslee Gross, of Coral Gables, serves as the assistant vice president of operations for Baptist Health South Florida.
- Dr. Kevin O’Neil, of Sarasota, serves as the chief medical officer of Brooksdale Senior Living, Inc.
- Dr. Kim Landry, of Gulf Breeze, serves as the EMS medical director and chief medical officer for Leon County EMS and Lifeguard Ambulance Service, Inc.
- Dr. Sarvam Terkonda, of Jacksonville, serves as the Site Medical Director for Connected Care in Florida for Mayo Clinic.
- Dr. Anne Burdick, of Miami Beach, serves as a Professor of Dermatology, Leprosy Program Director and Associate Dean for Telehealth and Community Outreach for the University of Miami, Miller School of Medicine.
- Mike Smith, of Tallahassee, serves as the Telemedicine Program Development Director for Florida State University, College of Medicine.
Copyright 2020 WJCT News 89.9. To see more, visit WJCT News 89.9.


text:
Ambassador, Natalie Miller Fellowship
Kerry Gardner AM is a documentary filmmaker focussing on art related subjects. She is Deputy Chair of The Australian Institute of Art History and sits on arts and environment funding committees of the Myer Foundation and Sidney Myer Fund and the Board of The Great Barrier Reef Foundation.
Kerry was recognised by the Governor-General and Chancellor of the Order of Australia, Sir Peter Cosgrove AK MC (Retd) in the Australia Day 2018 Honours List, where she was awarded an AM. Kerry was honoured for her significant service to the community as a philanthropist, a documentary filmmaker, and a champion of the rights of women and girls.
“I am thrilled, through my work as a filmmaker and as a philanthropist, to be able to advocate for a platform for talented young women, and to instigate national and international conversation about Women in Film and Television.
The Natalie Miller Fellowship was founded so that it might contribute to a more dynamic future for the Australian screen industry overall by highlighting and recognising the essential role that women can take in its ongoing innovation.
Internationally there is an ever-increasing awareness and discussion about the many exceptional women who have a valuable and significant contribution to make to the high-level decisions that inform the screen industry, yet are often excluded from those decisions.
The future industry will become richer in every way when it ensures that ALL its best are nurtured and encouraged to reach their highest potential. Inspiring leadership and greater diversity are pivotal to ensuring the development of a screen industry that is culturally sophisticated, economically sustainable, relevant and innovative.”
– Kerry Gardner and Andrew Myer


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I am intelligent, funny, full of energy! I am photographer, love travel, get to know new cultures and I love to be happy and live to the fullest every day. I would like to live in any country where we can form a beautiful family.
- Searching for
- Family status


Or the mayor who ran for president.
Bret Stephens: Gail, you’re a New Yorker and I’m now a former New Yorker, albeit one who is often in town. How are you feeling about the city these days? And do you have any preferences in the race to succeed Bill de Blasio?
Gail Collins: Bret, my city (and yours — if you work here you at least have rooting rights) tends to switch back and forth between regular party Democrats and feisty independents. De Blasio, a deep, dull Democrat, was preceded by Rudy Giuliani and Mike Bloomberg, who were very, very different versions of the political outsider.
Bret: Some might even call them Republicans. Go on …
Gail: And before that David Dinkins, who was the city’s first Black mayor. But also a clubhouse politician.
If it’s time for a new outsider, it does sort of seem that Andrew Yang ought to fit the bill. Yet he’s run a rather strange campaign — lots of interesting ideas but often the kind you hear from a guy who’s on a six-month internship at City Hall before being posted someplace else.
Bret: I’m generally sympathetic to Yang because — math! New York got a bailout this year from President Biden’s Covid relief bill, but the city is still going to need a mayor who can balance its books and create a business-friendly climate, especially if the financial industry deserts it and the M.T.A. continues to lose riders and revenue. I’m less thrilled about Yang’s $2,000 a year cash-relief plan for New York’s poorest, but post-pandemic I can at least see the case for it.
Also, who else has been supported by Anthony Scaramucci and Whoopi Goldberg?
Gail: OK, that’s definitely a dynamic duo. Meanwhile, I hear Rudy Giuliani’s son, Andrew, is thinking about running for governor. You’ll be voting in that race — how would you rate him versus Andrew Cuomo?
Bret: Hemlock or cyanide? Devoured by a saltwater crocodile versus bitten by a venomous sea snake? A year of solitary confinement in a supermax prison or an all-expenses paid trip to Cancún in the company of Ted Cruz? I’m trying to think of equivalently horrible alternatives.
Gail: Wow, that was quite a mountain of metaphors.
Bret: OK, I confess I don’t know a thing about Rudy’s son. And I try to subscribe to the words from Ezekiel: “The son shall not bear the iniquity of the father, neither shall the father bear the iniquity of the son.” So I’ll, um, keep an open mind.
Gail: Well, Andrew G. was introduced to the New York public on the day his father was sworn in as mayor. The little kid took over the ceremony, blowing kisses to the cameras while Rudy was trying to deliver his serious speech.
Bret: Now I remember …
Gail: Dad held up pretty well. I remember, at the time, saying that Rudy obviously had the right temperament for politics, since he could maintain such a show of good humor while losing the crowd’s attention to a cavorting child. So much for my talents at political analysis.
Bret: Your talents were just fine. Rudy proved to be a mostly terrific mayor who restored the city to glory and led us through 9/11. However, sometime later, on a fishing trip in the Catskills, he was captured by a race of dyspeptic, prank-playing space aliens who removed his brain and replaced it with Roy Cohn’s, which they had been keeping in a jar of formaldehyde.
That’s my theory and I’m sticking to it.
Gail: Not sure the real Rudy of 9/11 lived up to the later legend. But I do like that idea about Roy Cohn’s brain.
Anyhow, I think Andrew’s high jinks back at the 1994 inauguration rank, so far, as the political peak of his life. More recently, during the Trump era, he did a great deal of golfing with the president. It was his job, more or less.
Bret: Not what I would consider a qualification for high office. I definitely would like to see a sane Republican as governor. One-party rule is never a good thing, and a liberal state like New York could use a socially moderate, business-friendly chief executive like Maryland’s Larry Hogan or Massachusetts’s Charlie Baker.
Gail: And New York has had some. But except for Nelson Rockefeller our gubernatorial Republicans weren’t very exciting. Have we ever discussed the George Pataki years? No? At least with Andrew G. we’d have a Republican who knows how to putt …
Bret: I’ll take the Pataki years over the Spitzer-Paterson-Cuomo years!
Gail: Because …
Bret: Because Pataki-Not-Wacky? Because he never did what Cuomo is doing now, which is jacking up state taxes on the rich to some of the highest rates in the country. That’s just going to accelerate the exodus of people to income-tax free states like Florida. The large homeless population and rise in shootings isn’t exactly helping to keep people in New York, either.
Speaking of shootings, we have another nightmare in Indianapolis.
Gail: It breaks my heart because it feels so hopeless. We have a president who’s a champion of sane gun regulation, but lately there’s been a mass killing every week. Meanwhile, the House has passed a very, very, very modest reform to the background check system, which is in danger of dying in the Senate.
And remember the El Paso massacre? Apparently the Texas House doesn’t, since it just voted to eliminate the requirement that people get permits to carry handguns.
Why can’t we ever manage to get this dragon under control?
Bret: You know, after 9/11 the country collectively accepted that we needed far tougher security at airports and on airplanes. And most of us, conservatives included, were OK with all of it — standing in lines; taking off our shoes; removing electronic devices from our bags; throwing away large bottles; all the rest of it — because we understood there was a national emergency and a common-sense need to improve security.
Gail: While retaining the right to sigh deeply when those lines stretched on forever …
Bret: And aside from the ordinary griping, few Americans really considered it an infringement on our basic constitutional rights because we understood that personal safety is also a civil right and that a duty of government is to “insure domestic tranquillity.”
But we’ve had more than 45 mass shootings in the United States just since the Atlanta killings last month. Many of which we haven’t even heard of because there were more injuries than deaths.
Gail: True, a mass wounding doesn’t get as much attention as a road closing.
Bret: And yet we won’t even undertake the kind of basic precautions that we accept as normal and logical when it comes to boarding airplanes. The killer in Indianapolis had his shotgun taken away from him last year because of mental-health concerns, but he was still able to buy two rifles after that.
I wish I could convince my fellow conservatives of this. But noooooo. It’s like trying to talk someone out of an article of religious faith that seems preposterous to those outside the faith but fundamental to those within it. I’d offer an example of what I have in mind but I’d hate to insult anyone who believes in Immaculate Conception.
Gail: Speaking as the product of 14 years of Catholic education, I’m gonna bet you don’t know that Immaculate Conception refers to the belief that Mary was born free of original sin.
Bret: I stand chastened and corrected. To make amends, I hasten to note that Yiddish has at least 20 different words to describe useless Jewish men, of which I’m clearly a yutz, a putz, a schmendrick, a schlemiel, a schlimazel, or something else beginning with “sch.”
Gail: Hey, never heard of a schmendrick before. I believe this conversation is going to provide one great step forward in cultural understanding.
Bret: Or at least some mutual kvetching.
Gail: Which I hope we can continue soon over drinks or dinner. Do you feel as if we’re actually being sprung from pandemic purgatory?
Bret: It may be my congenital contrarianism, Gail, but after spending the better part of the pandemic feeling optimistic about the future, I’ve now sunk into deep fatalism. Cases are edging up again, driven by the new virus variants, and the steep decline in Covid deaths since January also seems to have bottomed out at an average rate of around 700 a day, which is just horrific.
Gail: Yeah, never going to accept the idea that 700 daily fatalities is good news.
Bret: The idea that we may all need boosters in six months or a year doesn’t faze me, and neither do the (very rare) instances of people reacting badly to the vaccines. But it also likely means continued social distancing, continued working from home, continued masking, continued nonsocializing, continued all-purpose nervousness.
Gail: Have you noticed that the most faithful mask wearers seem to be blue staters? I guess accessorizing only counts in some places when it involves carrying weapons.
Bret: I observe that Covid deaths in Texas have fallen by about 70 percent since the state dropped its mask mandate in early March. But I don’t draw any conclusions, since I really don’t know what to think anymore. Our colleague David Brooks wrote the other week that living through the last year has felt like one long Groundhog Day. Except that, unlike Bill Murray’s character, I’ve mostly been getting worse at everything.
Gail: Maybe we’ve gotten better at personal interaction that doesn’t actually involve being face to face. It’s been even more fun conversing with you than prepandemic.
Bret: Still miss the old kind of interaction. I’m getting my second shot in two weeks. Let’s get together for cocktails once I’m fully vaccinated — and not on Zoom.
The Times is committed to publishing a diversity of letters to the editor. We’d like to hear what you think about this or any of our articles. Here are some tips. And here’s our email: [email protected].


text:
You Should Know
April 2010 Issue
Get the Facts on Gourmet Salts, from Food Fashion to Health Impact
Image an artisanal Viking salt made from Danish seawater, slowly simmered in an old-fashioned cooking vessel over an open fire of juniper, oak, cherry, elm and beech woods. How might such a salt taste on wild salmon or a mozzarella tomato salad? Welcome to the world of gourmet salts, a culinary rage that covers the gamut, from artisanal hand-crafted sea salts to salts from exotic locations, and infused salts. You donít have to look hard to find specialty salts; theyíre in supermarkets, gourmet food shops and in prepared foods with increasing frequency. Itís natural for us to desire good salt; dating back to antiquity, humans valued salt so highly that they even fought over it and used it as currency.
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domain: food


text:
Background: With the burgeoning worldwide aging population, the incidence of Alzheimer’s disease
(AD) and its associated disorders is continuously rising. To appraise other relevant drug targets that could
lead to potent enzyme targeting, 13 previously predicted ligands (shown favorable binding with AChE (acetylcholinesterase)
and GSK-3 (glycogen synthase kinase) were screened for targeting 3 different enzymes, namely
butyrylcholinesterase (BChE), monoamine oxidase A (MAO-A), and monoamine oxidase B (MAO-B) to possibly
meet the unmet medical need of better AD treatment.
Materials and Methods: The study utilized in silico screening of 13 ligands against BChE, MAO-A and MAOB
using PyRx-Python prescription 0.8. The visualization of the active interaction of studied compounds with targeted
proteins was performed by Discovery Studio 2020 (BIOVIA).
Results: The computational screening of studied ligands revealed the docking energies in the range of -2.4 to
-11.3 kcal/mol for all the studied enzymes. Among the 13 ligands, 8 ligands (55E, 6Z2, 6Z5, BRW, F1B, GVP,
IQ6, and X37) showed the binding energies of ≤ -8.0 kcal/mol towards BChE, MAO-A and MAO-B. The ligand
6Z5 was found to be the most potent inhibitor of BChE and MAO-B, with a binding energy of -9.7 and
-10.4 kcal mol, respectively. Molecular dynamics simulation of BChE-6Z5 and MAO-B-6Z5 complex confirmed
the formation of a stable complex.
Conclusion: Our computational screening, molecular docking, and molecular dynamics simulation studies revealed
that the above-mentioned enzymes targeted ligands might expedite the future design of potent anti-AD
drugs generated on this chemical scaffold.


Following promising — but, by definition, mediocre — seasons last year, one might not have expected the Oklahoma Wesleyan University basketball teams to put together great 2012-13 campaigns.
But, brother have they!
The Lady Eagles take their 23-4 record into this afternoon’s single-elimination Midlands Collegiate Athletic Conference tourney opener against Central Baptist, at the Mueller Sports Center. Tip-off is 3 p.m.
Last year, the OKWU women finished just 16-15; this season they’ve won more than 20 games and are the undisputed regular season MCAC champs (15-1).
The OKWU Eagle men are just a bit less impressive.
They are 20-9 (11-5), after a 16-16 mark last season.
The Eagles also are home today, to host the MCAC South Tournament.
They are scheduled to be in action at 7 p.m. against Southwestern Christian.
There also will be another women’s game at 1 p.m. and a men’s contest at 5 p.m.
Good luck, OKWU.


Brand new rocket test promising target for anti-aircraft missile systems to be supplied to the Russian Armed Forces in 2013
«Maybe later this month will be accepted to supply modernized missile target. Supply of troops in the latest target missile is likely in 2013, «- said a source in the military-industrial complex.
According to him, the upgraded missile target created based on the target of the «Hog».
«Compared with the target» Hog «modernized missile target has tremendous speed due to higher energy propellant engine», — explained the source.
He said that in the powder engine modernized missile target used fuel combined with a highest specific impulse.
According to unofficial data, feature the latest target missile is its equipment hardware that even during the rotation of the target produces a stable information on the characteristics of the land slip, which is very crucial for obtaining unbiased data about how to get off the goal blunder at undermining the non-contact.
Target missile test promising anti-aircraft missiles and occupation calculations combat units are re-equipment of anti-aircraft missiles which have served their own time and decommissioned.


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There’s a difference between believing in God and listening to Him. Having knowledge is not the same as having a personal relationship. Go back to Eden and remember why we were created. God wants to be our friend. He wants to be in our lives and take care of us. He promises to do so if we let Him. But whoever listens to Me will dwell safely, and will be secure, without fear of evil. (Prov 1:33)
The secular world has no idea how this works and mocks anyone who claims to have faith. Don’t allow the opinions of others to make you doubt God’s perfect plan for you. If you develop ears to hear and spend time listening to Him, you will have peace and security that others around you will not have. They may mock, but they will also be insecure and fearful. Don’t live through the opinions of other people. Live through the convictions that you have based on who God is and what He promised for you.

domain: literature


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Spicy Mayo Chicken Bowl
Deep Fried Squid Legs
Grilled marinated unagi (eel) served over a bed of steamed rice.
Homemade Japanese Dressing
Benii House Dressing (S - $6.99 | L - $9.99) House Denanche $9.99
Assortment of Sushi Rolls
Authentic Japanese Cuisine
Locally owned & operated
Serving Guam since 2007, Benii Restaurant provides Guam with an assortment of traditional and fusion Japanese dishes. Boasting over 100 menu items, they succeed in satisfying a wide range of palates. Benii is one of few (if not the only) restaurant serving sushi as early as 10:30AM! Find yourself craving Japanese? Benii is the place to be.


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Copyright © 2018, Souvenir Pixels. Some rights reserved.
Attribution-NonCommercial-ShareAlike 3.0 Unported
Also check out my Instagram Hashtag Generator
The water in this pool was going round and round so when I took a photo with a long shutter speed it made these cool looking circles
I went on a hike up Cypress mountain in West Vancouver, to go to Eagle Bluffs to take some pictures of the view, but when I arrived at the bluffs there was no view ... I was in the middle of a big cloud and couldn't see more than 20 meters in front of me. Since I had carried my camera all the way up I was determined to find something to photograph and found this cool looking flower on the bluffs, different than a view of the city but not bad photo none the less.
Although there are a lot of sandy beaches in Vancouver, a lot of the shoreline around the city is covered in rocks that are exposed during low tide like in this photo.

domain: travel


Sade is a mother of four children and has lived in Hackney for 16 years. She is keen to encourage the values of diversity, equality and solidarity.
She is a Hackney Council Cabinet member, tackling homelessness and housing needs, fighting for a better deal for homeless people. She is also No place for hate champion for Hackney, working to bring unity and peace to the borough and its diverse communities and faiths.
She is a trustee of Newington Green Alliance and works with other local groups to improve community life in Clissold ward and area. She loves to play table tennis in Clissold Leisure Centre.
Sade is a member of Institute of Leadership & Management and other professional associations


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Terrible news has surfaced today for one of Calvin Harris‘ most well known vocalists of late, John Newman. The singer is most known for his 2013 hit “Love Me Again” as well as his features in “Blame” and the more recent “Ole”. Less well known are his previous struggles with a brain tumor. Four years ago he had a benign tumor removed, but the singer reported that the tumor has returned and that there are some cancerous cells present. He issued a formal statement addressing the reports:
“This was going to come out at some point and it’s probably best it’s out in the open now,” he said. “I have been monitored constantly since the first time I had the tumour removed. There was always a chance that it could return and it is unfortunate but it is something I am prepared to get through when the time is right, some point next year.
The medical staff have been absolutely amazing and I know I am in the best of hands. Nothing will ever stop me from doing the job I love so much, nothing will ever stop me from making music. People shouldn’t worry about me, the prognosis is good and there are so many people in far more serious situations. I just hope this in some way helps raise awareness for those people and encourages people to be tested and treated as early as possible. I am one of the lucky ones!”
It’s truly empowering to see John remain so stoic in the face of such tough circumstances, and all of us in the dance music community wish him the best and for a speedy recovery.


With the purchase of SonoCT Ultrasound technology, Cary Medical Center has a powerful new imaging tool for diagnosing and evaluating a wide variety of conditions. This ultrasound technology uses high frequency sound waves and their echoes to create pictures of internal organs. Traditional ultrasound bounces one sound wave straight to the tissue. The SonoCT has the ability to combine up to nine penetrating sound waves from different angles to create exceptionally detailed images. Using new techniques, including tissue harmonics and 3D and panoramic imaging, doctors can view tissue abnormalities better than ever therefore, helping to reduce the need for more invasive procedures. This is a huge advantage in diagnose diseases such as breast cancer. Additionally, this technology can do three dimensional virtual images for studies of internal organs including the heart, uterus, pancreas, kidneys, spleen, and prostate, as well as evaluate fetal development and detect any potential birth defects.


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AS IF THE chattering classes didn’t have enough to worry about, another little storm has been rumbling around their skies to disturb their quinoa-based mindfulness. AQA, the last exam board in the UK to offer art history as an A-Level, has decided to drop it. The History of Art A-Level is now history.
Source: The Fortnightly Review.
There’s art and there’s history in my book as well.


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Yes, you CAN buy a new modular or manufactured home without the wait or increased cost caused by the pandemic. IF YOU KNOW WHERE TO BUY!
Read more to see for yourself how Pratt Homes’ quick actions early in 2020 has contributed to:
- Saving our new homebuyers thousands of dollars over competitors’ pricing
- Providing homebuyers one of the largest inventories of new modular and manufactured homes
- Reducing or eliminating wait time as being seen across the country with home builders.
So, you decided to buy a home during a pandemic.
You weren’t the only one.
The year 2020 included one of the hottest real estate markets in 14 years, according to a December 15, 2020, article at MarketWatch.com. Home sales for the year were the best since 2006, and projections for 2021 show no sign of home sales slowing.
The effects of covid on manufacturing, and the resulting cost increases, have made buying a home more difficult; and in some cases, significantly more expensive. Not to mention the extended wait time.
All are frustrations you’ll face — unless you know where to buy.
A home purchase is typically the largest investment a person makes during their lifetime. But, the combination of an up real estate market and a pandemic have made finding the perfect home in which to invest problematic for a number of buyers.
Many of the difficulties can be avoided by working with a company who has weathered these types of economic storms before. Home dealers who have been in business for many years learned from previous experience and know how to keep their customers happy by planning ahead — way ahead.
For example, Pratt Homes, based in Tyler, Texas, ordered $4 million in home inventory beginning in June 2020. This was a large investment, which not only provided more selection for their clients, it also helped ensure prices were locked in before cost increases became a significant issue.
Pratt also diversifies their inventory sources. Their homes are constructed at 11 different building centers, which gives Pratt access to more readily available inventory, which, in turn, meets the increased demand of their customers.
At five of the 11 construction facilities, Pratt Homes is the largest volume customer, which provides an expeditious avenue for customers who require shorter construction times.
If you’re ready to purchase a new home, don’t let the pandemic dissuade you. It is possible to avoid the availability issues, cost increases, and delays others are experiencing. Doing business with an experienced home dealer who possesses the foresight to plan ahead will save you money, time, and have you in your new abode sooner than you thought possible.


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Writing a function - Arduino Forum
Arduino Client for MQTT. This library provides a client for doing simple publish/subscribe messaging with a server that supports MQTT. The library comes with a number of example sketches. See File PubSubClient within the Arduino application. Full API Documentation. Compatible Hardware.
Lesson 8: Writing Analog Voltages in Arduino - Technology
The Simple Guide to Writing an Arduino Program. Liz Miller Tutorials. 18. Jun. Share. Whether you’re a seasoned programmer or new to coding and robotics, writing an Arduino program is fairly easy. In this article, I’ve outlined everything you need to know to get started with Arduino programming. In this example, total will equal 4.
Arduino Playground - Library Tutorial
Arduino an opensource physical computing platform based on a simple microcontroller board, and a development environment for writing software for the board. The opensource Arduino software (IDE) makes it easy to write code and upload it to the board. It runs on Windows, Mac OS X, and Linux.
Arduino Tutorial #3 - Functions, return values and variables
The WriteSingleField Arduino sketch example reads an analog voltage from pin 0, and writes it to a channel on ThingSpeak every 20 seconds. Load the example in the Arduino IDE. Make sure to select the correct Arduino board and COM port. WriteMultipleFields: Writing values to multiple fields and status in one transaction with ThingSpeak.
Writing to Arduino from Excel Using PLX-DAQ
Arduino by Example Design and build fantastic projects and devices using The Arduino IDE 5 Hello World 7 Writing a simple print statement 8 LED blink 10 Summary 16 Chapter 2: Digital Ruler 17 implications. Initially, you will learn how to get started with the Arduino platform. The example-based, project-oriented setup of this book will
Arduino Code - Arduino Lesson 13 DC Motors - Adafruit
How to program Arduino with Labview step by step guide. Microcontrollers Lab 2 years ago 3 Comments. Prev Article Next Article . Tutorial 2: LabView uses graphical language and do not require writing lines of code. Instead we use graphical diagram to perform particular task. You can have a look at tutorial 1 …
Arduino - LibraryTutorial
Web Page Structure (HTML) Created on: 27 January 2013. Part 3 of the Arduino Ethernet Shield Web Server Tutorial. Below are two more HTML tags that were used in the first Arduino server example. Additional tags will be introduced in this tutorial as they are used. Heading Tag.
Arduino by Example - PDF eBook Free Download
Simple Arduino and HC-SR04 Example: After buying a HC-SR04 from Amazon, I could not get it to work out of the box. Not wanting to concede I had a DOA sensor on my hands, I searched for a simple example setup. After spending far too long on this than I felt I needed to, I decided to


SiR ft. Masego - "Ooh Nah Nah"
Over the last two years, Los Angeles singer/songwriter SiR has worked to grow his fanbase with impressive releases like 2015's Seven Sundays album and last fall's Her EP. After the recent announcement that SiR is TDE's latest signee, he's sure to have a whole new set of eyes on him now. And his newest singles dont disappoint.
SiR returned this week with the release of a sultry single titled "Ooh Nah Nah" alongside Virginia vocalist and saxophone player, Masego. Together the two created an irresistible track. It's much more seductive and relaxed than the previous single "W$ Boi" and showcases the sort of variety we can expect to hear on his upcoming Her Too EP later this month.—Adrienne Black


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IWC as knowledge broker at International Riversymposium
The inaugural Emerging Water Professionals Program was launched at this year’s Riversymposium. IWC has been recognised as a ‘Future Water Leaders Sponsor’ subsidising registrations for 15 of its current Master of Integrated Water Management students to attend the event.
A number of graduates from IWC’s Masters Program presented at this year’s symposium: Tom Alletson spoke about ‘Riverbank erosion stabilisation, ecosystem service enhancement and infrastructure protection’. Ronaldo Inguane shared his expertise on ‘Decentralised water resources management in Mozambique: challenges of implementation at the river basin level’. Short 10-minute speed talks were also held by IWC Master graduates Jacqui Reid, Abdula Bansuan, Bounthavivanh Mixap and Jessica Mowat.
Waterways Stewardship for Healthy Communities
The University of Queensland’s Global Change Institute hosted a special breakfast during Riversymposium. ‘Waterways Stewardship for Healthy Communities’ brought together catchment managers as well as community-focused water sanitation and hygiene professionals to consider the whole picture of a waterway that supports human and ecological communities. Integrated into this conversation was the consideration of the new United Nations’ Sustainable Development Goal 6 (SDG 6) to ‘ensure availability and sustainable management of water and sanitation for all’.
Declan Hearne, Project Officer of IWC and one of the panelists, highlighted the ambitious challenges laid out under the SDG 6. “Now the SDG 6 has to focus on bringing access to those not yet served, including remote and difficult to access communities and vulnerable groups. It is also not just about access but how to ensure services continue to function over time", he said.For more information on the Riversymposium, visit www.riversymposium.com.
Photo courtesy Piet Filet

domain: geography


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Take-Two Interactive Software shut down access to Grand Theft Auto Online, Red Dead Online, and several other games Thursday to support Black Lives Matter and demonstrators protesting the death of George Floyd.
The game developer will turn off services between 11 a.m. and 1 p.m. PT today to “honor the legacy of George Floyd” and support Black Lives Matter’s fight against racial injustice.
“To honor the legacy of George Floyd and in observance of his memorial service, today from 2:00-4:00 p.m. ET, our labels, Rockstar Games, 2K and Social Point, will be shutting down access to their online games, Grand Theft Auto Online, Red Dead Online, NBA 2K, Dragon City and Monster Legends,” said Alan Lewis, vice president of corporate communications for Take-Two. “In addition, our Private Division label will respectfully suspend their activities during that time. George Floyd’s memory will serve as a reminder that racism and the violence it incites cannot be tolerated. We are committed to supporting efforts to eradicate racial injustice and stand in solidarity with the Black community against this systemic issue that causes conflict and division in our society.”
In a follow-up tweet, Rockstar Games asked players to consider donating to funds that support families who have faced racism, Black-owned businesses, and protesters who have called for racial justice.
Following the memorial, we hope you will join us in further honoring the many victims of America's racial injustices by supporting their families, black-owned businesses, those marching on the streets, and coalitions through the organizations listed here: https://t.co/yIQu2R1pJb
— Rockstar Games (@RockstarGames) June 4, 2020
The U.S. is reeling from the tragic death last month of Minneapolis man George Floyd. Soon after this death, protesters took to cities across the country calling for an end to racism and police brutality against Black Americans. Four police officers involved in Floyd’s death have been charged, including Derek Chauvin, who held his knee on Floyd’s neck for eight minutes and 46 seconds. Chauvin is facing a second-degree murder charge.
Companies across the video game industry have come out in full support of the protests and Black Lives Matter. On Monday, Electronic Arts had planned to unveil Madden NFL 21 but ultimately canceled the event to support the movement. Electronic Arts CEO Andrew Wilson said yesterday that the company would also donate $1 million to organizations that fight racial injustice and give employees an extra paid day off each to volunteer and create positive change in their communities.
Sony canceled a PlayStation 5 event this week, where it was expected to unveil upcoming games for the console, and Epic Games said yesterday that it would delay Fortnite Season 3 until later this month. Infinity Ward postponed Call of Duty: Modern Warfare and Call of Duty Warzone Season 4 until further notice so players could focus on addressing racism.
Updated at 11:35 a.m. PT to include more details.
- Red Dead Redemption is coming to Nintendo Switch and PS4 this month
- How to get the Eclipse 50-car garage in GTA Online
- Even Grand Theft Auto Online has high gas prices in new expansion
- GTA 4 and Red Dead Redemption remasters reportedly shelved to focus on GTA 6
- GTA+ feels like last nail in the coffin for Red Dead Online

domain: sociology