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CUZAMÁ VIA TECOH, CHIQUILÁ, SABACCHÉ, OCHIL AND CHUNKANÁN BY BIKE, BUS AND COLECTIVO TAXI by John M. Grimsrud
Quiet country roads through picturesque Yucatan are well worth the effort and pay back with early morning tropical birds, plus brilliant tropical flowers that change season by season sweetly perfuming the air.
Escaping Mérida’s pushy-shovey horn honking, tail-gating belligerent bumper-to-bumper neurotic drivers is like flushing the proverbial toilet…and it feels so good when it is finally gone.
Our escape Mérida bicycle trip is only a little over 30 kilometers long from Tecoh to Cuzamá but the narrow little road coupled with a brand new paved section connecting Ochil to Chunkanán, that is not even on the map makes a neat cycling loop with plenty of photo opportunities.
A suggestion to anybody interested in this trip is to do it in reverse of the way we went. The reason being that if you are inclined to dine after your bike ride as we customarily do Cuzamá has positively nothing in that department, however the town just before, Chunkanán does have a cocina economica, but we cannot attest to its quality. Tecoh on the other hand does have a rustic cocina economica that serves ample portions of wholesome savory daily specials at affordable prices.
We began this trip by bicycling seven kilometers from our home in Mérida to the bus terminal on Calle 50 and 57 in the city center.
An hour later we disembarked the bus at Tecoh with our little folding bicycles ready for the fresh air and tranquility that awaited us touring wild Yucatan outback interspersed with quaint Mayan villages and aged haciendas along our “Gruta Ruta”.
This is Tecoh where a few months of absence have seen many changes. The quiet streets filled with silent bicycles and tri-cycle taxis now have converted over to motorized taxis as you can see in this photo where the back of a motorcycle is attached to an old tri-cycle
A new government required a new paint job of all things municipal and it was out with the old and in with the new. Above is the city hall complex that last year was neatly painted in a distinctive buff color…this political color change took place in every municipality over the entire state of Yucatan. Added to the environmental degradation was the ear splitting noise emitting from a new supermarket named, Super Willies, situated on the central plaza blasting the downtown into nerve rattling oblivion.
It is actually happening…at least the sign is up and that is a first step. We have yet to see the first of the bicycles or bikers participating in ecologically friendly touring of the cenotes that I jokingly named the “Gruta Ruta” because almost all of the cenotes are accompanied by caves or “grutas”. Note the spelling of the town Sabacche. On various maps you will find various spellings, such as Sabacché or Sabacchén…the standard of the industry in Mexico is that there is no standard.
This is where we make our turn to the north(left) onto the new road not yet on the map. For this insider piece of useful bicycling information we must thank our friends Basil and Alixa who conduct superb Yucatan bicycle tours. www.bikemexico.com
This is one of over one-hundred cenotes in this area designated on the map as; “Zona de Cenotes”.
Cenote Chonkila is very close to this new road, but most of the area cenotes require a long trek through woods by meandering foot path.
I must say here that most of these cenotes are situated in deep depressions in the rock with steep abrupt sides and no guard rails or warning signs. Cuidado mucho! “Be very careful” because the fall into unknown depths of water is only half of your problem…rescue could possibly be a very long time in coming.
On this eight kilometer stretch of new highway we may have seen one motor vehicle.
As you can see in the below photo of Jane standing on the rim of this cenote the abrupt drop of over eight meters or twenty-seven feet is straight down with nothing to hinder your decent and no way out.
Hanging from within the cave entrance on the north side of this cenote was a number of huge very active bee hives vigorously in operation. Swarms of busy bees find this location a nearly perfect environment protected from the weather and predators with a ready supply of water at hand.
The aromatic perfume of sweet honey scent was magnificently pervasive around the cenote where the multitudes of bees became aggressive enough to send Jane wheeling down the road swatting the busy little critters away while speeding into a strong headwind. She only received one sting because she was able to get them off her face as she speedily escaped.
These cenotes can be spotted by the experienced person from a great distance because around them are found tall trees watered by their long tap roots extending down into the water.
These cenotes made it possible for the ancient Mayan people to prosper and thrive in this otherwise waterless place devoid of rivers and springs.
Air plants cover the surrounding trees that are sending long roots down to siphon up cenote water. Jane lends scale to the cenote size as she stands on the rim.
Chunkanán is a very special because this is one of the last places in Yucatan still actually using the old Decauville narrow gauge railroad. By the late 1800s more than 4,500 kilometers of this one foot 7½ inch wide track had been laid across the Yucatan peninsula that used horse drawn carriages. 1,000 henequen haciendas were owned by just 30 families that were made wealthy on the backs of their Mayan slaves.
This is the narrow gauge railroad leading into Chunkanán with its well worn tow path along side the century old rail system still actively in use today.
Jane pictured with her Dahon twenty inch folding bicycle gives some prospective to the small size of the Decauville narrow gauge railroad track.
These tracks branch out to various cenotes while meandering past old haciendas and active henequen fields. This area is much the same as it was in the heyday of that industry that made Yucatan the richest state in Mexico around the time of the WWI.
Quiet downtown Chunkanán has its railway tracks leading through the neighborhoods.
The poor little old hacienda town of Chunkanán is finding a rebirth in its economy attracting busloads of tourists all the way from the port city of Progreso from tour ships to ride the antique rail system that generates enough cash to sustain the local economy.
This photo was taken in the early 1980s when Jane and I first visited Chunkanán with friends, arriving by a narrow dirt road before tourism became an industry here. What made this trip memorable besides our visit to a cenote with a deadly dangerous crumbling staircase was our race with a two meter, six and a half foot long rattlesnake, cascabel. As we rattled along at a fast horse trot the huge fat snake confined by a stone wall parallel to the track was actually slithering over the rough terrain faster than we were traveling.
Like a page out of the last century little Chunkanán reflects images of a time in Yucatan history when hacienda life was a prospering enterprise.
Gliding through the city center a horse drawn cart clanks rapidly along the narrow Decauville railroad tracks that were installed here back in the late 1800s and are still being actively pressed into service.
This is a small glimpse back into the unhurried past before the days of a motorized world when the horse set the speed for travel.
This is one of the many railroad spurs traversing quaint little Chunkanán.
From his office here on the street, the boss or “jefe” of the Chunkanán rail service, Bolas, busily dispatches the one car horse drawn carriages on tours ranging from half hour up to three hour long guided trips. Visiting customers arrive by tri-cycle taxi from Cuzamá, a distance of four kilometers on a very quiet little paved road.
Here comes one of those little one person powered tri-cycle taxis from Cuzamá.
In Cuzamá this road sign directs tourists to their number one attraction…cenotes.
Cuzamá has nearly nothing to offer in the way of shopping or dining but it is a connecting point with cross-country buses and colectivo taxis to Mérida.
Mérida might be filled with pushy-shovey horn honking, tail-gating belligerent bumper-to-bumper neurotic drivers but dining is no problem.
When we arrived at this cocina economica, Las Delicias de La Abuela on Calle 52 north at 41 and 43 it was nearly closing time and we were the last customers of the day.
This is Yucatecan style thinly sliced and brazier fried pork that makes a scrumptious meal that I stuff into tortillas yielding tantalizing tacos. I soak up the thin bean soup with the light French bread. The above meal set us back $30 pesos or three dollars and we got fed-up.
The day wasn’t complete without a stop at our favorite coffee shop, Caffé Latté in Itzimna on the way home for a iced coffee frappe…Our bicycles seem to run best when charged up on coffee beans.


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Original acrylic painting by Aimee Hofmann.
"Because There's Something About You" features hues in greens, violets, yellows, orange and touches of magenta and blue. This piece is embellished with gold metal leaf. This piece brings the feeling of Spring love, as it reflects colors found in wild nature!
24” X 30”
* Painted on canvas.
* Finished with varnish protectant.
* Artwork will be signed by the artist.
* A certificate of authenticity will be provided.

domain: design


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It is easy to feel like there is not much one person can do to fight against hate and create positive change. The sheer amount of divisiveness in our world is overwhelming. One thing we can do is listen. We can be better listeners in our homes, workplaces, and communities.
There’s one catch—listening is much harder than speaking. But as we know, the ability to listen is a critical skill for leaders and change makers. If deep listening doesn’t happen, it’s hard to develop empathy, share perspectives, and work together. And since humankind is dependent on collaboration, it’s a good idea to improve listening & team work skills.
Listening and collaboration, like any skillset, take practice and are applied differently with each context or new challenge. Improving a set of skills take time and practice, and no one ever said it was easy, but it is possible. The first step is to enter every conversation with an open mind—acknowledge and move past your own biases. This will help you listen with empathy, which in turn creates psychological safety and trust.
Trust only comes with mutual respect and dialogue, but it is the keystone that allows groups (large and small) to establish the other fundamental elements of effective co-creation: goal alignment, shared leadership, and information/resource sharing.
So, try listening. You just might learn something and make the world a better place at the same time.
Tools for Teams
People Styles Start by understanding where people are coming from – their unique communication style. People Styles is based on observable behavior, so no need to worry about remembering letters and colors. Here’s a snapshot…or you can read the book.
60-second share Each time you meet with your team, give each person 60 seconds to share out about what’s going on with them – at home, at work or otherwise. Don’t interrupt or comment…just listen.
Ask BIG QUESTIONS to help you grow…
- When do you feel respected & heard?
- How will you incorporate more empathic listening into your life?
- What can you do at work to ensure more voices are heard?
More Reading & Resources
- Bolton & Bolton. (2008). People Styles
- Duhigg, C. (2016). “What Google Learned from Its Quest to Build the Perfect Team.” NYTimes Magazine.

domain: psychology


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For today’s review, I check out a Disney Parks Exclusive Pop! Ride. Originally released in the beginning of 2019, there has been renewed interest in this piece after the release of two additional Pop! Rides from the same attraction this year. Here’s the Alice at the Mad Tea Party Pop! Ride.
In this Pop! Ride, Alice is riding a purple tea cup. Later releases of Cheshire Cat (Wondercon 2020 Exclusive) and Mad Hatter (Target Exclusive) on the ride showcase a yellow and blue tea cup, respectively.
I like how, in this sculpt, Alice’s hair is blowing in the wind. It easily showcases the wild motion on this ride.
While Alice is no longer available online, you’ll be able to find her on the secondary market at a decent price. Out of the three Mad Tea Party Pop! Rides, Cheshire Cat is the most expensive of the releases on the secondary market, given the extreme limited edition and way of getting him through the Funko Virtual Con associated with the cancelled Wondercon this year. Mad Hatter was the most recently released through Target to celebrate the 65th Anniversary of Disneyland, and might still be found in some stores.

domain: hobby


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The EU’s Asia Strategies in the Trump Era
- Bart Szewczyk, Adviser, European Political Strategy Centre, Non-resident Fellow, The German Marshall Fund of the United States, Brussels
- Janka Oertel, Transatlantic Fellow, Asia Program, The German Marshall Fund of the United States, Berlin
- Mathieu Duchâtel, Director, Asia Program, Institut Montaigne, Paris
- Alexandra de Hoop Scheffer, Senior Transatlantic Fellow and Director, The German Marshall Fund of the United States, Paris
Three years ago, the EU Global Strategy—seeking to promote peace and guarantee security of its citizens and territory, advancing prosperity of its people, and promoting a rules-based global order—provided a general framework for Europe’s policies toward Asia. It argued that there is a “direct connection” between European prosperity and Asian security and sought “to make greater practical contributions to Asian security” through partnerships with Japan, the Republic of Korea, and others.
Three geopolitical factors—the return of great power rivalry, China’s growing assertiveness, and emerging U.S.-China tensions—have raised anew the question of what should be Europe’s strategy toward Asia. What are Europe’s core interests and objectives in the region, and how much commonality or diversity of interest is there within Europe in its relations with Asia? What are the main instruments that the EU or individual EU member state have at their disposal to serve their interests in Asia? What are the implications of the tensions between China and U.S. for the transatlantic relations?

domain: geography


text:
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Singing for the Ages
To honor the acting legend Cicely Tyson, Yolanda performs her signature song, "The Battle Is the Lord's," at the 2011 BET Honors ceremony.
(Photo: Michael Buckner/Getty Images For BET)
UNCF An Evening of Stars 2013 All-Access Pass
UNCF, An Evening of Stars 2012: Seat Check
UNCF, An Evening of Stars 2012: Red Carpet Rundown
UNCF, An Evening of Stars 2012: Rehearsals
Class Acts: Faith Evans
Class Acts: Anthony Hamilton
Class Acts: Trey Songz
UNCF, An Evening of Stars 2012: Show Highlights
The Many Faces of Anthony Anderson
Class Acts: Tyrese
Class Acts: Eric Benet
Class Acts: Melanie Fiona
Class Acts: Keyshia Cole
Class Acts: Charlie Wilson
Class Acts: Chaka Khan
© 2014 BET Interactive, LLC, a wholly owned subsidiary of Black Entertainment Television LLC. All rights reserved.

domain: artistic


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For more than fifty years, Forge Theatre in Phoenixville has been a part of the arts and culture scene in the community. Located on First Avenue, the theater hosts a varying selection of live plays and musical throughout the year.
The roughly 83 seat theater is a “black box” theater which refers to the changeability aspect of the stage and seating arrangements per each production. General Productions Chair of Forge Theatre, Marnie Herzfeld, said the theater is popular because of its smaller atmosphere.
“Coming up is our 52nd season,” said Herzfeld. “Live theater in the community, it does bring in an area of the arts. We’re quite affordable for senior citizens and we have season ticket holders who have been members for years. They come to all the shows, they like the ambiance. The like they intimate nature of the theater. We’re small which means they can hear, they can see. If they tell us they have movement restrictions they’ll be seated right in the front row. None of the seating is fixed, it’s movable.”
Herzfeld said Forge Theatre originally began as an itinerant theatre group in the area, which lasted for twelve years until the First Avenue location was purchased in the early 1970s. Before that, the building had been F.B. Neiman and Sons Funeral Home. After remodeling the building, the theater opened its 12th season in the new location and has remained there ever since.
“As a community theater we feel like we are able to be more competitively priced and more accessible,” said Herzfeld. “I had several people tell me that they had seen The Drowsy Chaperone (a recent show in June) in New York, they liked ours better. I think the reason was they feel more connected to the actors because it’s closer, it’s more intimate. It makes them more connected to the production. People loved seeing tap dancing right in front of them, these intricate dance steps, right in front of them. We’ve had that experience with other shows too.”
A committee decides on the different productions that will show each year, and the committee also changes members every year. Each production has its own production team which is made up of the director, producer, stage manager, music director, choreographer, set designer and lighting designer. Herzfeld said the production team is responsible for building the set.
“Generally speaking we try to do two musicals, two comedies and then drama and someplace in there a mystery. People like mysteries. We try to have a little bit of everything for everybody,” Herzfeld said.
The director and the production staff of each show holds open auditions for the show castings. Auditions are typically held two-and-a-half months before opening night.
“We have open auditions and they can come from everywhere. We’ve have actors come from as far away as Delaware and New Jersey,” said Herzfeld. “Sometimes it’s people who get started coming and are in a show and like the atmosphere. Quite often it’s somebody who sees an audition for a show they like or a part they want, and they show up. Lots of people stay around, (and) sometimes they’re once and done.”
“Now that Phoenixville has a night life and restaurants, you can go to dinner and a show,” Continued Herzfeld. “We’re kind of hoping we might be Manyunk West. We like people to have options. It’s diversity. It’s different aspects of the arts, it’s having a variety, it’s having things for people to do in Phoenixville.”
Show schedules, tickets and more information is available at www.forgetheatre.org

domain: entertainment


Wasps ready to face champions Saracens
Wasps will travel to Allianz Park this weekend to face reigning champions Saracens. Wasps have started the season strongly with three wins out of their opening four games and will face a stern test against a Saracens side that have only lost once at home since the Tyrrell’s Premier 15s began.
So far this season Wasps have put in a number of impressive performances and faced difficult tests which put them in a good position for a tough fixture at Allianz Park. In their last fixture two weeks ago, they battled against a resilient Worcester side to pick up their third bonus point win of the season.
Saracens are so far undefeated in the Tyrrell’s Premier 15s with the maximum number of points collected. Their game against Wasps will be their toughest test yet as they are yet to face a side in the top half of the table.
Wasps make five changes from the side that beat Worcester Valkyries at Tywford Avenue. The visitors welcome back experienced England international Nolli Waterman at fullback and club captain Kate Alder at inside centre.
The black and gold also bolster their forwards with two Ireland internationals. Claire Molloy returns to the side after an outstanding start to the season, picking up four tries in her two appearances. Hooker Cliodhna Moloney makes her debut for the club after signing in the summer and battling her way through injury.
The final change sees Nora Baltruweit return in the second row to partner Sarah Mitchelson, as Liz Crake moves into the back row.
Speaking ahead of the match head coach Giselle Mather said, “Playing the Champions is always a game elite athletes relish. It is a genuine challenge for us, individually and collectively, to test our skills and structures to the limit, which is something we are really looking forward to.
It will undoubtedly be a very physical contest and should be a great game to watch. We feel ready for that challenge.”
15. Nolli Waterman 14. Amy Wilson Hardy 13. Katie Mason 12. Kate Alder 11. Tova Derk 10. Lizzie Goulden 9. Claudia Macdonald 8. Liz Crake 7. Claire Molloy 6. Sarah Mitchelson 5. Nora Baltruweit 4. Alice Sheffield 3. Hannah West 2. Cliodhna Moloney 1. Claire Purdy
16. Kate Hallett 17. Kany Adefemiwa-Afilaka 18. Emily Maisey 19. Nicola Smith 20. Flo Williams 21. Louise Dodd 22. Garnet Mackinder


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Molecular mimicry between streptococcal and human proteins has been proposed as the triggering factor leading to autoimmunity in rheumatic fever (RF) and rheumatic heart disease (RHD). In this review we focus on the studies on genetic susceptibility markers involved in the development of RF/RHD and molecular mimicry mediated by T cell responses of RHD patients against streptococcal antigens and human tissue proteins. We identified several M protein epitopes recognized by peripheral T cells of RF/RHD patients and by heart tissue infiltrating T cell clones of severe RHD patients. The regions of the M protein preferentially recognized by human T cells were also recognized by murine T cells. By analyzing the T cell receptor (TCR) we observed that some Vβ families detected on the periphery were oligoclonal expanded in the heart lesions. These results allowed us to confirm the major role of T cells in the development of RHD lesions.
Keywords: Rheumatic fever, rheumatic heart disease, Streptococcus pyogenes, T cell response, autoimmunity, molecular mimicry, M protein, heart proteins
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domain: biology


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New Delhi, May 16 (PTI) Northern Arc Investments, a subsidiary of Northern Arc Capital has announced its sixth debt fund with a base size of Rs 150 crore (USD 23 million) to invest in the finance sector with a green shoe option to raise it to Rs 250 crore (USD 38 million).
The IFMR FImpact Income Builder Fund will invest in areas like microfinance, small business loan finance, affordable housing finance, commercial vehicle finance, agri-business finance and corporate finance, a company statement said today.
The fund is set to make 8-10 investments with an average investment ticket size of Rs 20 crore. Till date, Northern Arc Investments has secured commitments totalling in excess of Rs 1,000 crore across all its funds, the company said.
It said having already raised Rs 110 crore, the sixth fund has already made investments in four corporate finance and microfinance companies namely LEAP India, Satya Microcap, Fusion Microfinance and Chaitanya India Fin Credit. The final close of the fund is expected by the end of first quarter of this fiscal. PTI KPM

domain: finance


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My husband is Filipino and I am Caucasian, so our kids are a solid mix of both of our genes. None of them are as brown as him or as white as me, but they are on the lighter side compared to him. They just look like they've all got a nice tan going.
DH: black hair, dark brown eyes, brown skin
Me: naturally curly/wavy brown hair (I straighten it), green eyes, pasty white skin
DS1: black hair, dark brown eyes, tan skin (most resembles my husband)
DS2: dark brown hair, brown eyes, tan skin (most resembles my dad as a child)
DS3: curly brown hair, brown eyes, light tan skin (most resembles me, but with my MIL's nose)
DD1: dark brown hair, greenish brown eyes, light tan skin (she looks like my DS2 as a baby, but I don't know who she'll resemble as she grows)
We often say our kids look like "white" Asians. :) I'd say they take after both of us genetically.


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Short Reads for the Long Road – Episode 2 – Nyarlathotep
Today’s story, Nyarlathotep was written by H.P. Lovecraft and read by Roger Carden.
This story originally appeared in the November 1920 edition of The United Amateur, and is available online at Project Gutenberg (http://www.gutenberg.org/).
A portableNouns production. The original text of this story is now in the public domain. Production Copyright© 2015 by portableNouns, LLC.

domain: literature


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It’s not very often you will hear me talking about football, but quilter, Ann Hill, has combined football and quilting in a fantastic project. Ann […]
Manchester Quilters is the creation of Liz Delves.
© Liz Delves 2022. All rights reserved.
Please don't copy my stuff, I've worked really hard on it!


HOUSTON (Houston Chronicle) – Imagine getting to work, restaurants and shopping, not by car but by boat. A local development firm plans to make that a reality in Houston.
Locally based Caldwell Cos. will break ground this year on The Boardwalk at Towne Lake, a waterfront development to be built along the master-planned community’s 300-acre lake, complete with boat parking. The development will include restaurants, shops and offices centered on a large green space.
The Caldwell Cos. also announced the addition of a new 120,000-sf Kroger grocery store to be built in the 2,400-acre Towne Lake at the southwest corner of Tuckerton and Barker Cypress Roads.


United States President Barack Obama defended a supporter of Republican presidential nominee Donald Trump as the crowd at a Democratic rally in Fayetteville began yelling at him when he stood up with a pro-Trump sign.
Obama repeatedly told the crowd to "hold up" as Hillary Clinton's supporters started booing a man who stood up with the sign supporting the Republican presidential nominee.
The man, dressed in a military uniform, stood in the aisle of the arena stands and just held up his sign, which was one of the usual sizes. He didn't say anything.
"No, wait, wait, wait, wait, wait. Hold up. Hold up. Hold up. Hold up. Hold up. Hey, hold up! Hold up! Hold up! Hold up! Hold up! Hold up! Hold up, hold up, hold up!," said the president as the audience did not listen to him.
"Hillary! Hillary! Hillary" they kept yelling.
"Hey, hey, hey, hey, hey, listen up! Hey, everybody! Everybody! Hey! Hey! Listen up! Hey! I told you to be focused, and you're not focused right now! Listen to what I'm saying," Obama said as he appeared to be frustrated.
"Hold up! Hold up! Hold up! Hold up! Everybody sit down and be quiet for a second. Everybody sit down and be quiet for a second. Now, listen up! I'm serious, listen up. You've got an older gentleman who is supporting his candidate. He's not doing nothing -- you don't have to worry about him," Obama said.
"This is what I mean about folks not being focused. First of all, we -- hold up! Hold up! First of all, we live in a country that respects free speech," Obama said amidst applause from the audience.
Obama told the crowd that it appears the man was a veteran, and they should respect his service.
"So, second of all, it looks like maybe he might have served in our military, and we've got to respect that. Third of all, he was elderly, and we've got to respect our elders. And fourth of all, don't boo vote! Come on," he said.
Obama asked people to pay attention and reminded his supporters of free speech rights in the US.
"Because if we don't -- if we lose focus, we could have problems. This is part of what's happened here during this election season. We just get stirred up for all kinds of reasons that are unnecessary. Just relax," he said as the audience and the president burst into laughter.
At a late-night election rally in Hershey and Pennsylvania, Trump alleged that Obama "screamed" at his supporter.
"Obama spoke in front of a much smaller crowd than this and there was a protester who likes us. He was talking to the protester, really screaming at him," Trump said.
"If I spoke the way Obama spoke to that protester, they would say he became unhinged," said the Republican presidential nominee.


Tesla Cyber Rodeo event is finally happening, and the opening of Tesla Gigafactory Texas is being celebrated. The new car assembly plant will help fuel EV leaders focus on carbon emission reduction. Here are some that are to be known about Cyber Rodeo and what to expect from the factory in the coming days.
Tesla dubs its factories with the giga prefix. Giga is the numerical prefix for billion. The practice likely came from the batteries. EV makers measure battery manufacturing capacity in gigawatt hours. A gigawatt hour of annual battery-making capacity can produce enough batteries to make, perhaps, 10,000 to 15,000 electric vehicles a year. Furthermore, the Cyber part in the “Cyber Rodeo” refers to Tesla’s pickup truck called the Cybertruck that eventually will be made in Austin. Also, Tesla won’t make Cybertrucks for months. The company’s first product at the new plant will be the Model Y. The party should start around 4 p.m. local and run until midnight. Global Equities analyst Trip Chowdhry wrote recently that Gov. Greg Abbott and Sen. Ted Cruz are expected to speak.
The plant has taken roughly two years to build and is designed to produce about 500,000 cars in its initial configuration. Tesla likely will expand the plant in the future and add battery-making capacity on site.
In the coming days, investors can expect videos of tours that show advanced robotic car assembly and new paint facilities. All new car plants use modern technology. Robots aren’t news, but Tesla still pushes the boundaries of manufacturing technology. The company is adopting giant die-casting presses that form part of a vehicle frame from molten aluminum. The technology is designed to reduce the amount of welding needed to make a car.
It will take time to ramp up capacity at the new plant. Analysts estimated the plant might produce 100,000 vehicles in 2022. Full production rates should be reached in about a year, assuming there are no more supply-chain problems like a lack of semiconductors. A chip shortage has constrained automotive production for more than a year.
Piper Sandler analyst Alexander Potter calculated that Tesla’s most productive plant in Shanghai can produce roughly 3,400 vehicles a day. That’s about 1.2 million vehicles a year, but car plants typically can’t run full out all year. That’s the kind of production number Tesla will want from Austin in the coming years. Achieving that level in Texas also will require more capital investment.
Tesla stock reacted positively to the opening of the German plant near Berlin earlier this year. The German plant was opened officially at the end of March. Coming into Thursday trading, Tesla stock has risen about 5% since then. The S&P 500 and Dow Jones Industrial Average have declined about 0.9% and 0.3%, respectively, over the same span.


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Reduce Your Energy Cost
- Start saving today
- Affordable systems
- Reduce your energy costs
- Several rebates and incentives
- Be part of clean green energy.
- Care for the environment.
- Get rid of your electric bill or reduce costs.
- Increase your property value.
- Energy cost rising - Get Solar Now!

domain: economics


text:
Country Music is the fifty-eighth studio album by country artist Willie Nelson. The album consists in a compilation of country music standards. Produced by Grammy-winning T Bone Burnett, it was released on April 20, 2010 by Rounder Records, and according to Nelson is the first traditional album he has ever recorded. It was his first release in the 2010s.
At the American Music Awards, Sarah McLachlan performed an 'Angel' duet with Pink and it is easily one of the most touching duets ever. Cody Jinks Actions Speak Louder Dimebag Darrell Country Music Whiskey Album Sayings Logos Music Film. Music, Film, TV and Political News Coverage.
This exceptionally long two-record set seems to prove two things: the family can jam (sometimes to the extent that you ask yourself what the point is), and Nelson seems to be bored with some of his own material. Instead of singing, he talks his way through the songs. If you need this to fill out the collection, that's one thing. If you want to hear him do these songs, look for the studio albums.
Listen to Classic Country Gold by Various Artists on Deezer. Автор на текста: Darrell Edwards - George Jones, Композитори: Darrell Edwards - George Jones. 05. I Walk The Line (Single Version). Classic Country Gold.
Album Trading My Sorrows. Let The River Flow Lyrics. Let the poor man say I am rich in Him Let the lost man say I am found in Him Let the river flow. Let the blind man say I can see again Let the dead man say I am born again Let the river flow Let the river flow. Let the river flow Let the river flow Holy Spirit come, move in power Let the river flow. Let The River Flow" Track Info. Trading My Sorrows Darrell Evans.
It's all at your fingertips. Preparing for worship is so much easier with WorshipChords. Print in any key, or stay paperless and display it all on any device. Try new chords and arrangements on the fly. You'll look like a musical genius, instantly. I play both guitar and piano when I lead worship, so having chords I can transpose or print anytime has been a total game changer.
Black Midi Create Cathartic Experimental Rock on their Debut ‘Schlagenheim’. Hyped UK band takes bracing noise in fascinating new directions. The rstar detours from country-rap to rap-rock. Willie Nelson’s ‘Ride Me Back Home’ Is Another Sturdy Set of Late-Life Wisdom. By Jonathan Bernstein. TV Expand the sub menu.
Tracklist Hide Credits
|B||Let The Music Live
Engineer – Willie Correa
- Published By – Young Nutt Music
- Lacquer Cut At – A+R Record Manufacturing Corporation – 0106X51
- Written-By, Producer – Willie Correa
- Written-By, Producer, Engineer – Darrell Nutt
Barcode and Other Identifiers
- Rights Society: BMI
- Matrix / Runout: 0106X51-A A+R GID
- Matrix / Runout: 0106X51-B A+R GID


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Below are two links to bicycle route maps put together with the help of local bicycle clubs the City of Peoria, and the Tri-County Planning Commission. The first link is for a web-based GIS map of Peoria/Tazewell/Woodford counties, and the second link is for a printable PDF map of just the bicycle routes in the City of Peoria. Roads on these maps have been suggested by local cyclists as being safe to ride on – most of the time. Caution should still be taken at busier times of the day when people are driving to and from work.
**The Illinois Valley Wheelm’n are not responsible for any problems that may arise while using these roads for bicycling. Due to timing issues of roads becoming busier after their initial construction and map updates, a road suggested for travel may not remain safe for travel after the map has been produced**
Peoria Area Bicycle Map (Active web-based GIS map version)
Peoria City Bicycle Map (Printable PDF Version)

domain: travel


Articles & Whitepapers
The Future of Autonomous Electric Bus Systems: How autonomous electric bus systems could revolutionize public transportation and reduce carbon emissions
The world is facing an urgent need for sustainable transportation solutions as we grapple with the challenges of climate change. The transportation sector is a major contributor to carbon emissions, and as such, it is essential that we explore innovative solutions that can help to reduce these emissions. Autonomous electric bus systems have emerged as a promising solution that could revolutionize ...
Why there is such a demand. Off-highway vehicle manufacturers have to comply with increasingly stringent emissions legislation. The chief objective of which is to reduce NOx gases, hydrocarbon gases, ...
ComEd, in partnership with the Chicago Metropolitan Agency for Planning (CMAP), the Respiratory Health Association (RHA), Argonne and Oak Ridge national laboratories, announced it has been selected by the U.S. Department of Energy (DOE) to receive ...
Equipment & Solutions
As well as the standard units, we design and produce individual high pressure water jetting systems in accordance with our customer needs. The configuration is flexible to respective requirements.


Remarks by Harry C. Alford, President and CEO, National Black Chamber of Commerce
Palm Beach, Florida
Thank you. I appreciate being invited to speak with you today.
This is a critical time for our country.
For the first time in recent memory, it may be possible to take positive action to curb the onslaught of regulations and fundamentally reform the regulatory process—but this opportunity may not last.
And failing to act has serious consequences.
Our future growth and personal freedoms will be jeopardized if we allow the nation to continue to be run by activists, obstructionists, and groups with narrow interests that don’t represent the greater public good.
As we sit here, the cumulative mass of regulations imposed by federal agencies grows larger and larger, produced by a system that is nearly unaccountable to the people and institutions that must comply.
Let me stress that regulations are not a bad thing, in and of themselves.
They provide the rules of the road that businesses need to be able to operate.
They help keep workers safe, our food, air, and water clean, and protect us in thousands of ways so that we can live longer, healthier lives.
Our modern society could not function without some rules.
But many of our rules are overly complicated and impossible to comply with. There are simply too many rules, and many cost much more than they deliver.
The increasing size, scope, and complexity of regulations now threaten to exceed our ability to understand and comply with them.
Take the Waters of the U.S. rulemaking, for example. Although the Environmental Protection Agency assured the public the rule was simply a change in a definition, businesses, farmers and landowners came to realize that the rule will put their land under federal control, rather than state regulation.
The rule would have disastrous consequences for construction and maintenance projects, as well as day-to-day activities like farming, ranching, and forestry.
The Waters of the U.S. rule is one of the largest federal land grabs in our lifetime, and EPA shrugged it off as just a change in a definition.
Likewise, the Federal Communications Commission’s now-withdrawn set-top box rule would have hit the cable industry hard and created widespread disruptive effects on copyright, licensing, and commercial agreements in the entertainment industry—possibly harming minority companies that provide content.
The problem isn’t just that regulations are big and complex; agencies now crank them out one on top of the other, without pausing to see if a rule did its job before imposing another, more stringent one.
For example, EPA regularly imposes new air quality standards long before communities can comply with current ones and without really knowing if a new standard is needed.
The price tag for existing regulations—not the mega-rules that were finalized in the past three years—amounts to more than $2 trillion a year, according to a 2012 study conducted for the National Association of Manufacturers.
That’s about the size of Canada’s GDP.
Household ultimately get hit with thousands of dollars of regulatory compliance costs in the form of higher costs for goods and services.
Small businesses, who cannot readily pass their increased costs to their customers, are forced to absorb those costs or go out of business.
These regulations also impose a cost to our personal freedoms. Thanks to our administrative state, our ability to make important choices is becoming limited.
From choosing a doctor to selecting a place to build a home, regulations tell us what we can and can’t do. Regulations even tell us what kind of light bulb we can buy.
How is America affected by all of these rules?
The French political scientist and historian Alexis de Tocqueville once said that the centralized regulatory state
“covers the surface of society with a network of small complicated rules, minute and uniform . . . [people] are rarely forced by it to act, but they are constantly restrained from acting; such a power does not destroy, but it prevents existence . . . ‘til the] nation is reduced to be nothing more than a flock of timid and industrious animals, of which the government is the shepherd.”
The modern-day regulatory state often prevents companies from acting, discourages them from investing, and creates an environment where regulatory risk blots out the entrepreneurial spirit.
The problem with our regulatory system is not just the number or complexity of rules, or the tremendous costs they carry, but the rulemaking process that allows so many rules to be made so easily.
The current regulatory system shuts out affected parties and average citizens as deals are made between activists and agency officials behind closed doors.
The agencies use cherry-picked data and unfounded assumptions to push their agendas forward.
The vast majority of legal restrictions affecting Americans are not passed by Congress after thoughtful deliberations, but are issued by unelected bureaucrats through an expedited rulemaking process.
For large, complex rules, public comment periods of 30 or 60 days are simply too short to digest the rule, analyze its impact, and offer thoughtful comment.
Even when stakeholders comment, agencies often focus only on supportive comments, downplaying adverse comments and ignoring concerns about how a rule will impact jobs, growth, and economic freedom.
To make matters worse, agencies often allow “sue and settle” agreements—a sweetheart deal between a government agency and a likeminded interest group.
This is where activist groups sue a federal agency and the agency chooses not to fight and quickly agrees to a settlement.
A federal court signs off on the agreement, and the agreement binds the agency.
Through sue and settle key agency choices about how and when to take regulatory action are made in secret.
We need to have a regulatory system that makes agencies accountable to the people, allows the public to meaningfully participate, and upholds the rule of law.
The business community must insist on good governance.
And only by reforming the rulemaking system itself will we achieve that goal.
We know that reform is possible. In December 2015, after many years of effort, Congress finally passed a law that streamlines the permitting process for energy projects.
Implementation of the FAST-41 Act is ongoing, and promises to make the permitting process for faster and more transparent.
Three pieces of legislation now before Congress are our best opportunities to continue such reform.
They have bipartisan support and the strong backing of the National Black Chamber, as well as many other groups.
First, the Regulatory Accountability Act would modernize the 1940’s vintage Administrative Procedure Act, which governs our federal regulatory process.
The Administrative Procedure Act became law decades before EPA, OSHA, the EEOC, and scores of other agencies were created, well before agencies started issuing rules that cost a billion dollars or more each year.
Although the APA worked pretty well for most of the 70+ years it has been law, it doesn’t force agencies to be accountable when they propose billion-dollar rules like the Stream Protection Rule, or they want to restructure the economy with a rule like the Clean Power Plan rules.
The Regulatory Accountability Act would require more transparency and public participation.
It would require agencies to let the public see the information the agency relies on for the rule.
Agencies would have to show that their rule is really necessary and that a cheaper alternative isn’t available.
And it would hold agencies accountable for the nature and quality of their data.
If an agency uses shaky data or makes false assumptions, agencies must be held responsible for failing to do their job right.
For the most important rulemakings, the Regulatory Accountability Act would give the courts the information they need to see if an agency did its job right—or if the agency cut corners, misled the public, or turned a blind eye to problems with its rule.
The Regulatory Accountability Act passed the House on January 13, 2017 by a 235-188.
The second piece of legislation is the Regulations from the Executive In Need of Scrutiny (REINS) Act, which passed the House on January 5, 2017 by a 237-187 vote.
The REINS Act would require any regulation which would have an economic impact of $100 million or more to be approved by Congress and be signed by the president.
If the regulation fails to get these approvals after 70 days, it would become null and void.
The REINS Act and the Regulatory Accountability Act would work in tandem to ensure that major regulations are reasonable and well-supported, and they are acceptable to Congress and the White House.
The third piece of legislation is the Sunshine for Regulatory Decrees and Settlements Act.
Under the Sunshine Act, agencies would have to give the public plenty of notice when they want to settle a lawsuit with outside groups.
Interested parties such as states and affected industries would have a chance to voice their opinions before a deal is finalized.
For industries like utilities, this would have given them an opportunity to object to the Mercury Air Toxics Rule, which promised big reductions in mercury but only delivered additional soot reductions at a cost of nearly $10 billion per year.
For farmers, the Sunshine Act would have given them an opportunity to be at the table when EPA agreed to federalize the cleanup of the Chesapeake Bay.
Another EPA land grab, the Chesapeake Bay sue and settle agreement gave EPA the ability to have a say over development and farming practices in six states and the District of Columbia.
Finally, under the Sunshine Act, a court that would sign off on a settlement agreement or consent decree must be informed about any objections to the settlement received from the public or stakeholders.
So a court would learn that a settlement agreement between activists and EPA will shut down a utility, causing Native American workers to lose their livelihoods.
Or that a state will have to take funds from other essential programs to pay for new EPA requirements resulting from a settlement negotiation the state was shut out of participating in or even knowing about.
Regulatory reform is ultimately about good government, which leads to a better economy. If we are to hold on to our personal and economic freedoms—and our character as a can-do nation—we must act now.
If we can get the Regulatory Accountability Act into law, we will have a much better opportunity to slow down the torrent of new regulations that now threaten to overtake virtually every aspect of American’s daily lives.
The first important step is to get engaged, contact your member of the U.S. Senate, and voice your opinion about the importance of passing the RAA and the Sunshine Act.
Senators need to understand that the RAA passed by a bipartisan House vote in just the second week of this new Congress. The iron is hot and the Senate to act before the best opportunity in a generation is lost.
I want to thank you again for having me and for the time and energy you have devoted to advancing this important priority.


The Office of Attorney General William Tong
1995 Formal Opinions
Page 3 of 3
You have requested our advice on whether first selectpersons who exercise criminal law enforcement powers must successfully complete the training requirements established by the Municipal Police Training Council ("MPTC") pursuant to Conn. Gen. Stat. § 7-294d.
This is in response to your letter dated October 16, 1995, wherein you requested a legal opinion from this office concerning the computation of cost of living adjustments (COLAs) under the Workers' Compensation Act for the years 1994 and 1995 for persons injured prior to July 1, 1993.
I am in receipt of your letter dated September 21, 1995, in which you emphasize your concern that the establishment of a third casino in this state not jeopardize the level of revenues currently being received by the State under the Memorandums of Understanding (MOUs) between the State and the Mashantucket Pequot and Mohegan Tribes. In response to this concern, you issued an RFP that required each casino proposal to provide a guarantee that the State will receive, over a three-year period, up to $610 million to make up for any cessation in the Tribes' payments under the MOUs.
This is in response to your predecessor, William E. Curry's request for an opinion inquiring whether the Departments of Mental Health, Mental Retardation, and Children and Family Services may operate trustee accounts for their outpatient clients as activity funds pursuant to Conn. Gen. Stat. § 4-52, et seq.


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Photo Gallery 2 Images
BUTTE COUNTY, Calif. – Healthcare workers in Butte County will receive free reusable face shields donated by North Valley Community Foundation and Feather River Health Foundation thanks to a unique partnership involving county public health departments, Chico State University and Idea Fab Labs.
Health officials said the goal is to produce and distribute 20,000 face shields in the next four to eight weeks in Butte, Glenn, Tehama, and Colusa counties.
The Public Health Departments in the listed counties all conducted surveys in order to come up with the number of face shields needed.
Completed shields will be transported to each county’s public health office, then distributed by the county. The shields will be given to hospitals, doctor’s offices, urgent care clinics, dental offices, veterans clinics, student health centers and more, health officials announced Thursday.
“It has been incredible to watch this come together,” said David Little, executive vice president of NVCF. “Everybody recognized a need for personal protective equipment for all health care workers, from doctors in emergency rooms to hygienists in dental offices. Then everyone worked to figure out how to make it happen.”
The project started at Idea Fab Labs, a Chico tech company. Enloe Medical Center requested face shields from Idea Fab Labs Director Erin Banwell, who showed Enloe administrators prototypes made on 3D printers. Enloe initially ordered 500, then requested thousands.
That’s when the university joined the effort. A team of professors, in consultation with Enloe Medical Center, developed a 3D printable frame that supports a clear plastic face shield. The frames were initially produced remotely by a collection of university and community-owned 3D printers because the university was shut down.
Enloe requested 3,000 shields and the university effort was turning out 100 to 200 per week.
NVCF offered to help with funding for the shields but sought to include three surrounding counties, as well as other health care workers aside from hospitals.
Faced with a demand that was closer to 20,000, Greg Watkins, chair of the university’s Department of Mechanical and Mechatronic Engineering and Sustainable Manufacturing, received permission from the university to begin producing the frames using plastic injection molding machines in the engineering labs on campus.
Students designed and fabricated the molds and are now running production. They are producing about 600 frames per day – and may be able to double that.
“This started as a volunteer effort from engineering faculty and students who wanted to help out,” said Watkins. “Everybody came together and put in a lot of hours to make this happen. It’s gratifying to see our students apply their design and manufacturing education and utilize our campus facilities to help out the local medical community.”
Idea Fab Labs is cutting transparent plastic shields that snap onto the frames produced at Chico State. The shields and the frames can be cleaned and reused. Idea Fab Labs was a small tech startup in Chico that now has more than a dozen employees making PPE products.
NVCF and Feather River Health Foundation split the cost of the plastic material and the labor so the shields could be donated. NVCF and Feather River Health Foundation both have coronavirus relief funds and this month formed a partnership to combine resources.
NVCF has now distributed more than $750,000 in grants for coronavirus relief.
Butte County Public Health officials said they will contact healthcare providers and offices when the shields are ready and available. Organizations who missed the survey may still be added to the distribution list by emailing BCPH at: PublicHealthDOC@buttecounty.net

domain: medical


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Nana Okyere Tawiah-Antwi with some of the participants
The Atwima Kwanwoma Assembly has inaugurated a district youth parliament for the area, an initiative aimed at inculcating in the youth values of democratic practices and principles.
It was inaugurated under the auspices of the National Youth Authority (NYA) to ensure government’s continued show of determination, dedication and commitment towards youth development through enhanced budgetary allocation to the authority for effective and efficient delivery of its youth-centred mandate.
It was held at the Methodist Church at Twedie in the Ashanti Region on Tuesday, and was under the theme: ‘Social Media: Beneficial or Harmful Tool For Youth Development’.
The District Chief Executive (DCE) for Akwima Kwanhoma, Nana Okyere Tawiah-Antwi, said the youth parliaments are preparatory grounds for the youth to take up responsive roles in society, acquire or improve skills such as public speaking, debate, presentation, research and organisational skills, thus, aiding their personal development.
He appealed to them to make the most of opportunities available, identify their localities most pressing needs and come up with innovative ways to address them.
Mr. Tawiah-Antwi also urged the privileged members forming the youth parliament to work with common goal towards helping youth development in the district where a lot of potentials abound.
He advised participants to embrace the values of discipline and self-respect to effectively collaborate with the government to achieve sustainable life in future.
The Ashanti Regional Director of NYA, Orwell George Asamoah, indicated that the youth parliament would help the youth see themselves as active participants towards local development.
He said the concept of the youth in parliament would also help tackle issues that affect the development of youth directly, namely violence, teenage pregnancies, security issues, fallen standards of education and improvement in health and drug abuse.
On his part, Padmore Adu Boakye, a district youth officer, explained that the concept is non-partisan and would enable the youth parliamentarians to engage duty bearers to implement programmes that seek to improve the well-being of the youth in the district as well address challenges and issues related to the youth sustainable future.
The youth parliament was divided into majority and minority caucuses with three directorates—speakers, leaderships and clerks.
FROM David Afum, Kumasi

domain: sociology


Brock Solutions have been working on a baggage handling solution at Dublin Airport and needed a supply of Test Bags that could be used to test the newly installed sort control system.
High risk of fire and electric shock in Terminal retail premises, due to a number of factors including poor maintenance, copy parts used, not keeping to Gatwick Airport installation requirements.
BEUMER Group are a preferred supplier to a major UK airport for Baggage Systems. BEUMER required test bags to prove the function of new X-ray systems at this major airport.
In order to verify compliance with EMC (Electromagnetic Compatibility) product requirements, Kenwood acquired a screened EMC chamber which needed electrical services.
As technology has advanced, port terminal equipment manufacturers have been able to convince their clients that quay cranes and yard machinery benefit tremendously from the incorporation of varying degrees of redundancy.
Heathrow Airport has a target availability percentage for its HBS machines, but had no way of measuring against it.
With critical front of house reclaim carousels, failure of these assets compounds challenges for Newcastle International.
Testing new Standard 3 screening machines and their associated conveyor systems is part of a rigorous commissioning process. Our solution was the provision of specialist Test Baggage, designed to test the systems capability to detect threats.
Already one of the busiest airports in the world, Singapore’s Changi Airport is expanding to accommodate more planes and passengers. Changi Airport Group and its baggage handling system (BHS) service partner CHS Engineering Services migrated that software to Microsoft Azure. With the platform change, Changi benefits from improved application performance and availability.


text: Tumor progression could be understood like a collaborative work of mutations and development elements, which propels cell proliferation and matrix invasion, and in addition enables evasion of drug-induced apoptosis. orderly response to development factors give a trove of potential oncogenes and tumor suppressors. Intro Beyond deep knowledge of systems root tumor initiation and development, contemporary cancer study ultimately strives to build up even more efficacious and selective anti-tumor medicines. Within the last 10 years, this avenue of intense study has been influenced from the ‘oncogene dependency’ theory . Appropriately, cancers which contain multiple hereditary and chromosomal abnormalities are reliant on or ‘addicted’ to 1 or several genes for maintenance of the malignant phenotype. Therefore, reversal of only 1 or many of these abnormalities can inhibit malignancy cell development and translate to improved success rates. A good example is supplied by the multiple mutant types of the epidermal development aspect receptor (EGFR) in lung tumors. Low molecular pounds inhibitors from the EGFRs kinase successfully inhibit lung tumors if they express among the mutant, constitutively energetic types of EGFR . Another obsession may be exemplified by breasts malignancies that overexpress HER2, a kin of EGFR, that are successfully controlled with a monoclonal anti-HER2 antibody . While tumor genome sequencing initiatives continue steadily to identify even more mutant forms and applicants for targeted therapies, the exceptional multiplicity of mutations in solid tumors , along with natural adaptive systems that result in patient level of resistance , established formidable limits towards the oncogene obsession strategy. It really is worth it noting that many, Rabbit Polyclonal to SLC27A4 rather effective tumor drugs focus on non-mutated cellular elements. They are the estrogen receptor in breasts cancers, the microtubule network in a number of tumors, as well as the vascular endothelial development aspect (VEGF) in colorectal and various other cancers. Furthermore, anti-EGFR antibodies successfully inhibit colorectal tumors even though EGFR in these malignancies isn’t generally amplified or mutated. Oddly enough, the current presence of amphiregulin and epiregulin, two ligands of EGFR, in colorectal tumors predicts response to anti-EGFR antibodies . This shows that the healing antibody achieves influence by preventing autocrine or paracrine, stroma-mediated loops concerning EGFR and among its seven ligands. In keeping with this interpretation, development factors play important jobs in most stages of tumor development, including clonal fixation of oncogenic mutations, recruitment of bloodstream and lymph vessels towards the developing tumor and improving dissemination of tumor cells, resulting in colonization of faraway organs (metastasis) . For instance, an in vivo hereditary display screen for genes that enhance metastasis of breasts cancers to lungs determined two ligands of EGFR . Another, essential contribution of development elements to tumor development entails chemotherapy- and radiotherapy-induced autocrine loops that permit medication resistance. For instance, by producing cisplatin-resistant MCF-7 cells, it had been found that medication resistance associates with an increase of EGFR phosphorylation, high degrees of AKT1 activity, inactivation from the p53 pathway and up-regulation of amphiregulin appearance . Furthermore, knockdown of amphiregulin appearance by specific brief interfering RNA led to a nearly full reversion from the resistant phenotype. To conclude, in-depth knowledge of the jobs played with the stroma and development elements in tumor development might identify book applicants for therapy as well as for mixture treatments targeted at delaying the starting point of level of resistance to drugs. Powered by this inspiration, our mini-review shows cytoplasmic and nuclear activities of development elements, with an focus on AZD8055 transcriptional rules by EGFR, a comparatively well-understood development factor receptor program. Cytoplasmic signaling pathways triggered by development factors (observe Figure 1) Open up in another window Physique 1 Receptor-mediated signaling as well as the initiation of transcriptional regulationReceptor tyrosine kinases (RTKs), triggered by development factors (GFs) transmission through many pathways to operate a vehicle adjustments in the transcription of particular RNAs. Adapters (yellowish), kinases (green) and additional signaling protein (grey) bind to phosphorylated tyrosines (encircled P characters) around the triggered RTK, and stimulate particular downstream pathways. For example, upon binding to phosphotyrosine, phospholipase C, PLC, is usually triggered to cleave the membrane lipid phosphatidylinositol 4,5-bisphosphate, PIP2, into inositol 1,4,5-trisphosphate, IP3, and diacylglycerol, DAG. Pathway activation culminates in adjustments in transcription element (TF) activity, resulting in adjustments in RNA manifestation. The degree AZD8055 of activation of every of the pathways will change with regards to the identity from the RTK. Also demonstrated is the unfavorable regulator CBL, which binds to phosphorylated tyrosines and ubiquitinates AZD8055 the RTK traveling its internalization. Additional RTK specific unfavorable regulators such as for example MIG6 aren’t demonstrated. Growth elements bind to and activate receptors in the plasma membrane . Regarding EGFR, receptor activation upon ligand binding entails development of homo- and hetero-dimers between EGFR as well as the additional members from the ERBB family members. Pursuing ligand-induced dimerization, EGFR family phosphorylate one another to.


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Copyright: Stian Rekdal
« In september of 2011 I spent 2 weeks travelling around Morocco covering over 3200km (2000 miles). It was my first visit to this beautiful country, but it will definetly not be the last.
Locations include: Marrakesh, Ait Ben Haddou, Dades Gorge, Erg Chebbi, Fez, Meknes, Chefchaouen, El Jadida, Essaouira and Legzira beach. »


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HOLY HERETIC DEVOTIONAL- JULY 22, 2016-BE STILL
Compiled by Mercy Junction Justice and Peace Center Council Member Sadie Morgan
“Peace, be still!” — Mark 4:39
Since the idea of “be still” is so foreign to me, I rambled around the internet for some ideas on these meditations. I lost track of one I read concerning the above verse, so I’m going to paraphrase what it said. No intent to plagiarize, just sloppy with my references.
The commentary I read said to notice the exclamation mark! In the story, the panicked disciples on the boat woke Jesus from a sound sleep in their fear of the fierce storm. This was no imploring statement from him but commanding authority – like when we yell at the kids “HUSH – BE QUIET!!!” He followed this with a stinging rebuke of his followers, “Why are you so timid? How is it that you have no faith?”
This shows me that, just as there is a time for gentleness, there is also a time for firmness – a time for a whisper, and a time to shout. Some days (most days) when I’m pulled in a dozen different directions by my own inertia vs. urgent daily needs vs. long-term important goals, I need the shouted “BE STILL!!!” I still struggle with it.
Today’s Action: Today when things get the most frantic, practice saying out loud, “Be still.” Shout it, if you need to hear it loudly. If someone else hears you and asks, be ready to give an answer (I Peter 3:15).
Sharing: Did you yell at yourself to “be still” today?
** Don’t forget your gratitude journal at the back of your print edition of Holy Heretic!
To learn more about becoming a member of the Fellowship of Heretics and receiving our print daily devotional guide each month, visit http://www.mercyjunction.org/fellowship-of-heretics


1963 ... Fortune Magazine
... article from 'Fortune' magazine about the initial deployment of America's 'Minuteman' missile system. The minuteman used a solid rocket propellant and was much more reliable and ready for immediate launch- as opposed to the previous temperamental liquid fueled ICBMs. Also first to use all integrated-circuits- no vacuum tubes!
The Minuteman III remains the USA's main deterrent missile force with 450 currently deployed.
...much is made of the fact that missile commanders wear side-arms; supposedly to protect against one of them going berserk and trying to launch a missile. A single officer initiating a launch is just not possible.
Since the mid- 50's most Strategic Air Command personnel, including aircraft mechanics, wore firearms while on duty. SAC also had a 'two-man' rule- minus the cloak and dagger. In any operations involving nuclear weapons, from gassing-up bombers to standing watch in an underground command capsule like the one shown above, nobody was ever to be alone or out of sight.
... here's the AV Kid with the super-cool opening to the 1983 movie "War Games'. It is a fairly accurate portrayal of a watch change at missile command bunker. The missiles shown in the movie are Titans not Minutemen.Part of the launch sequence is the simultaneous turning of two keys only once. This starts an automatic countdown.


Coronavirus case counts are on the rise in Massachusetts after weeks on the decline as more contagious variants circulate, restrictions ease and people gather amid vaccine optimism, infectious disease docs tell the Herald.
The case tallies are ticking up during the COVID-19 vaccine rollout, while a significant majority of the state’s population is still not vaccinated and won’t be for months.
“We’re close. We can see the light at the end of the tunnel, but we’re not there yet,” said David Rosman, president of the Massachusetts Medical Society. “So peoples’ inclination to gather and take off their masks is too early. If we just hold on for another month or two, then we can be entirely clear of this.”
The state’s case counts, while rising, are significantly lower than at the start of the year when the average was 6,240 cases per day.
Single-day case tallies have dropped dramatically since then, but have ticked up recently along with the positive-test rate. The average case counts for the last week of February were 1,523 cases, followed by 1,378 in the first week of March and 1,362 during the second week of March.
But in the last week, the average case counts rose to 1,566 infections per day. Meanwhile, the number of high-risk “red zone” communities increased for the first time in several weeks, and the estimated active case count started climbing.
The rise in cases could be driven by the easing of state restrictions and more infectious variants, said Boston University epidemiology professor Matthew Fox.
“As people see fewer cases they relax and take more risks than they would at the time when they are seeing high rates,” Fox added.
Massachusetts relaxed restrictions further on Monday, entering Phase 4.
“I think we are opening up just a bit too early,” Fox said. “As vaccinations increase, deaths will start to come down and as long as the new variants are not more lethal or able to evade the vaccines, then we can open up and see cases increase a bit without seeing deaths increase.
“But we are not quite there yet, so I’d like to see us wait a few more weeks to get more shots delivered and more immunity in the state,” he added.
The worst of the pandemic is in the rearview mirror, according to Todd Ellerin, director of infectious diseases at South Shore Health, but he predicts more cases, hospitalizations and deaths in the coming weeks.
“I’m concerned about us taking our foot off the brake and accelerating when cases are leveling off and even potentially increasing,” Ellerin said. “This is not the time to rip off our masks and congregate in large crowds.”