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By Laura Calugar
Charlotte’s housing market is displaying one of the strongest recoveries among U.S. metros this cycle, with growth attributable to the city’s thriving economy, low cost of living and high quality of life. Among the nation’s top destinations for immigration, Charlotte also boasts steady employment growth, which has made the city an attractive target for new and expanding businesses, while supporting long-term demand for new units.
Increases in population, development and public projects boosted employment in professional and business services, along with trade and construction. The $1.16 billion LYNX Blue Line extension running from uptown to UNC Charlotte and the $150 million Gold Line Streetcar project have significantly contributed to strengthening both of these sectors. Moreover, universities in the area feed a talent pool of highly sought-after young workers for new and expanding tech firms. Fintech (financial technology) is an important source of tech growth in Charlotte, building on the region’s notoriety as a top financial services hub.
Roughly $769 million in assets traded this year through July. Following last year’s cycle high in deliveries, some 6,800 units are slated for completion in 2017, about 2,000 fewer than in 2016. With developers focusing on upscale assets, high demand for working-class units is pushing rents up. However, we expect rent growth to remain steady, keeping appreciation at 2.5 percent in 2017.


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Alaskan Cowboy, Doug Briney Partners With Triplestrand For Debut Single's International Promotion
Doug Briney, the Alaskan Cowboy, has hired Triplestrand Promotions to handle the international promotion for his debut single, "More Than Just A Farm."
Triplestrand will be taking the song to radio stations around the world, including ECMA chart reporting stations throughout Europe, Asia, Australia, as well as stations in North America. Dixie McCorkell of TSP said, “We’re happy to be on board with Doug. He’s definitely going places!” Michael Stover of MTS Management, who handles publicity for Mr. Briney said, “I’ve worked with Dixie and Triplestrand before, and they are one of the best in the ECMA promotion game. We’ve charted several singles across the European continent with Bryan Cole, and I’m sure Doug is going to enjoy similar success.” The single will be available to international radio via the TSP compilation disc, shipping out in late February.
Doug Briney is an ICMA Best Male Singer nominee, as well as a two-time finalist in the KBear Country Idol competition, held in Anchorage, Alaska. For more information, please visit www.dougbriney.com.
Triplestrand Promotions is a leader in international radio promotion, having scored countless numbers of ECMA chart hits for their clients. They were honored with the award for ECMA Best Country Sampler in 2005, and have been nominated every year since 2007. For more information on TSP, please visit www.triplestrandproductions.com.
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About MTS Management: MTS Management is a full service artist management firm, specializing in publicity and promotion, social media marketing and management for the independent artist. Clients include Doug Briney, Bryan Cole, and Xander Demos. www.mtsmanagement.vpweb.com.


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Lippi rules out Italy supervisor role
MILAN, Sep 14 (Reuters) Italy's World Cup-winning coach Marcello Lippi has rejected the idea of a return the national team in a supervisor capacity.
Guido Rossi, the head of the Italian Football Federation, had floated the idea of Lippi taking on such a role at the head of the federation's technical department.
''I will never be a supervisor because that is not my trade,'' said the former Juventus coach who led Italy to victory on penalties over France in July's World Cup final in Berlin before standing down.
Lippi gave backing to his replacement, new Italy coach Roberto Donadoni, who has come under criticism following the poor start to the Azzurri's Euro 2008 qualifying campaign.
''I respect him a lot and I am convinced he will find a good relationship with his players,'' Lippi said in comments reported by the news agency ANSA.
Italy drew at home to Lithuania and then lost 3-1 to France in their opening Group B games but Lippi said the world champions would find their form again.
GREAT LAD ''I have no doubt that they will get back to great form and that Roberto will be able to bring the best out of them -- he is a great lad. He was a kind of coach on the field when he was a player,'' he said.
Lippi has previously said he intends to return to club coaching but confirmed he was in no hurry to get back into the game just yet.
''At the moment I am still enjoying the aftertaste of the World Cup which I think will last a good while yet. It would be daft to take on a club after one or two weeks of the season,'' he said.
''I have had some calls from non-Italian clubs but I didn't meet with any club directors,'' said Lippi, who would be high on the list of any top European clubs who might change coach in mid-season.
Lippi had been linked with Manchester United during the World Cup but rejected the rumours by pointing out his lack of English language skills.
Asked about his English he replied ''It is a little bit better''.
REUTERS AY HS2035

domain: news


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We loved the food at this locally owned cafe and they have great coffee too, it was my favourite cup while we visited. I was happy with the many vegan options and the staff were willing to switch up some ingredients to accommodate my diet! I had the falafel, which was well done and the taco salad looked great too!
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Eileen & Christopher
The epic cliffs of the New South Wales coastline, together with the warm afternoon sunshine, create the perfect backdrop for Eileen and Christopher’s striking sunset engagement shoot. James Day was on hand to capture the understated elegance of the afternoon, and the tender chemistry between this lovely couple.
Of how they came to be, the couple tell, “We met when we were both accepted into the Summer Vacation Program at an accounting firm.” And Eileen remembers a sweet love story of when they first moved in together on Valentine’s Day, “In a tremendous gesture of supreme romanticism, Christopher hid four Valentines cards with four different poems in various moving boxes. Brilliant plan. Except that he hid them in all the boxes that were not unpacked immediately and I didn’t discover them until a few days later!”
Eileen tell of how they became engaged, featuring a little spoiler cameo from the bride’s parents! “Six months after moving in together, Christopher knew that this was the real thing and decided to do the right thing and visit my parents so he could get their blessing before proposing. Naturally they were delighted but, due to cultural differences, there was a little confusion as to whether I should be part of this conversation and whether they could entirely give their blessing unless I was there. More importantly they were unaware that this meeting was supposed to be a secret. When Christopher took me to Bennelong Restaurant at The Opera House with the sole intention of having a great lunch and proposing to me, halfway through the lunch I received a phone call. Christopher had no idea what the call was about as I was speaking in Chinese, and he was all in his own head and nervous about what he was about to do, and hoping it would all go well. What Christopher didn’t know was that it was my dad on the phone telling me everything about Christopher’s visit and what he had said. Two days had passed, and he was curious and just wanted to know what was going on. Big spoiler alert!! However, always the professional, I didn’t let on to him what had happened and after lunch as we walked around the Opera House, he brought me to a quiet spot and recited a poem he had written for me. Then he got down onto one knee, popped the question and in a veritable wave of excitement I said a resounding “Yes”. The moment was no less memorable, no less beautiful, no less magical for us…”
Of their photographer, and their engagement shoot, the couple explain, “We trust our photographer James, and he took us to one of his favourite spots. James has a knack for capturing beautiful landscapes and he did a great job incorporating that into the shoot. HE made the shoot incredibly relaxing and fun for us.” And they certainly had plenty to say about why they love him so much! “James Day is the best photographer ever! We love him. He is great with people, and knows how to get the best out of his couples. He is focused and a true professional – James will always give you his all. Nothing phases him either. Whatever curly situation arises, he remains calm and composed and will guide you through it. He has a wealth of knowledge and so much experience. He is also incredibly creative and knows exactly what to do with the camera to create the most stunningly beautiful photos. Photos with emotion, depth and soul. Most importantly, he is an all around nice guy and fun to hang around with!
Of her groom, Eileen gushes, “I loves Christopher because he makes the world a fun place to be. He strives to make me laugh. He is cheeky and very smart. Every day, and sometimes every hour, he tells me that he loves me, and makes me feel like the most special person in the world. But also, beneath this comical layer, is a person full of integrity and honour, who always does the right thing even when, at times, others are being less honourable.” And Christopher loves everything about Eileen. “I love her passion for the things she loves – it is unparalleled. She is intelligent, hilarious and strong. She brings a light and an energy to my life that makes it impossible for me to remember a time when she wasn’t everything to me.”
Such an incredibly beautiful engagement session. Thank you Eileen and Christopher, and to James Day, for sharing this lovely shoot.
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6 Creative Ways to Show That You Care During COVID-19 – PawnHero Blog. The past few months have been extremely tough for everyone.
With the world battling the COVID-19 pandemic, it’s no secret that some people are having a hard time managing through the crisis. Apart from dealing with the health and economic ramifications of the virus, people around the world are also dealing with the psychological challenges it brought. Due to limited mobility and the lockdown rules imposed by the government, many are unable to be with their loved ones. Breadwinners in the metro or abroad cannot visit their relatives in their hometowns because public transportation needed to cease to mitigate the spread of the virus.
Luckily enough, we live in a digital age, when we can bring those that are far away closer to us. Creative Ways to Show You Care During COVID-19 1. Miss watching primetime telenovelas with your family? 2. Aside from your immediate family, make sure to check in on your other close relatives, as well. 3. Is your brother’s birthday coming soon? All About Wine: Facts, Figures, and Health Benefits.
Out With the Old: 4 Ways to Ease Into the New Normal. Skip to the content Sign-In Menu Out With the Old: 4 Ways to Ease Into the New Normal The fight against the COVID-19 pandemic has ushered in the so-called new normal, which loosely translates to a new way of doing things and living life.
Under the new normal, people stay home more, spend less time in public places, and limit their activities to the most essential ones to avoid spreading or being infected with the virus. From Adapting to Evolving While the narrative is mostly focused on “adapting” to the new normal, a lot of people are skipping a subtle yet important step: grieving the “old” normal. That’s why SHOOR promotes not just adapting, but realigning one’s lifestyle to the new normal. That said, if you’re still not sure how to get started, here are 5 tips to help you ease into the new normal. 1. Now that you are working from home more often, you may want to try incorporating some new rituals into your (tele)commutes. Here are some ideas to start with: Go on a bike ride. 2.
What’s Next: 5 Trending Activities During the Pandemic. Skip to the content Sign-In Menu What’s Next: 5 Trending Activities During the Pandemic The COVID-19 pandemic caused significant changes.
Aside from dealing with the health and economic consequences caused by the virus, many are also experiencing emotional challenges due to the lockdowns and self-isolation measures. Since staying at home and repeating the same things every day can be mentally draining, embracing change and trying out something different is a must. With free time on their hands, people are starting to pick up new hobbies. To help you get started, here are some hobbies and online activities you should try today: 1. Learning how to cook different cuisines is the next best thing to traveling to your favorite spots. Whether you’re a beginner who wants to learn how to cook or an experienced chef who wants to discover new recipes, taking part in cooking classes can do wonders for you. 2. Indoor gardening can be a relaxing and fruitful hobby. 6 Best Practices to Ace Your Social Media Customer Support - SuperStaff BPO.
Before social media took over the world, customers could only reach out to you—specifically, your customer support agents—with concerns through phone calls, in-person conversations, or later on, via email.
In addition to frustratingly slow response times, another issue with that kind of support was that reasonable grievances would only make it as far as the agents. Although your customer support team would help each individual customer on a case by case basis, the root cause of the call volumes were never escalated past the operational floor of the call center. In effect, businesses were simply ignoring complaints, thinking that a handful of disappointed clients couldn’t possibly hurt their bottom line. Luckily, recent technological advancements are now changing how brands treat customer feedback.
One such development is social media. What is Social Media Support? The practice makes perfect sense. 6 Social Media Customer Support Best Practices Provide immediate response.


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Meghan Trainor is engaged! Must watch the emotional moment when her boyfriend proposed her.
The "Hopeless Romantic" singer said "Yes" to actor Daryl Sabara Thursday and shared a touching engagement announcement with fans on Instagram.
Meghan Trainor celebrated her 24th birthday Friday and enjoyed the holiday season with family and friends. But her boyfriend, Daryl Sabara, offered one extra reason to rejoice when he dropped to one knee and pulled out a ring.
The 25-year-old "Spy Kids" actor made Trainor his fiancee Thursday in a perfectly planned proposal. Ryan Trainor, Meghan’s older brother, captured the moment on camera and both Trainor and Sabara shared the breathtaking video on Instagram.


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Many people who suffer from a debilitating injury or illness are unsure whether their condition enables them to receive Social Security Disability Insurance (SSDI) benefits. The answer isn’t always obvious.
To be considered, applicants must have a condition that meets Social Security’s “disability” definition, meaning an illness that prevents them from working for at least a year or could result in death.
Which conditions are considered “automatic” for receiving benefits?
While no definitive list exists for SSDI-qualifying conditions, the best resource is the Social Security Blue Book, which details the mental and physical disorders that meet the requirements. Part A, for adult conditions, details 14 categories, including:
- Chronic kidney disease
- Cardiovascular: Heart failure, arrhythmia and congenital heart disease
- Endocrine: Diabetes and thyroid problems
- Digestive: Liver or bowel disease
- Respiratory: Cystic fibrosis, asthma and COPD
- Immune system: Lupus, HIV and inflammatory arthritis
- Musculoskeletal: Spinal disorders, joint pain and amputation
- Blood: Hemophilia, sickle cell disease and other anemias
- Skin: Dermatitis, burns and ichthyosis
- Congenital: Disorders affecting multiple systems, such as Down syndrome
- Speech and other senses: Impaired sight, hearing or speech
- Neurological: Parkinson’s disease, traumatic brain injuries, ALS, MS and epilepsy
- Mental and cognitive health: Dementia, depression, bipolar disorder and schizophrenia
The above conditions are a few examples of those covered under SSDI guidelines. Consult the Blue Book for a detailed list. Part B has childhood listings, which contain the above categories and add a child-specific section.
The Blue Book is not the final word on eligibility
Even if your condition isn’t included in the Blue Book, or it’s on the list but you don’t meet the requirements, you may still qualify for benefits if an examiner determines your impairment is severe and you are unable to work as a result.
It is advisable to work with an experienced disability attorney to file the appropriate paperwork. Many claims are denied at the initial stages because people don’t provide mandatory information. Your lawyer understands how the system works, including special rules that Social Security uses to determine eligibility.

domain: medical


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Cannabis Legalization The Will Of The Majority
The most recent Pew Research Center Poll shows a majority of American voters favoring the legalization of cannabis by 52% to 45% opposed. http://tinyurl.com/csbv2hz
Other polls are showing similar support with a Quinnipiac University poll with 51% for and 44% against http://tinyurl.com/bbgb3pg, Angus Reid coming in at 54% to 42% http://tinyurl.com/d7tgtbe, Rasmussen at 56% to 36% http://tinyurl.com/ccbg4n8, Public Policy Polling at 58% to 34% http://tinyurl.com/ccgmn6s, and YouGov giving us 51% to 26% http://tinyurl.com/8ovba3u. Not ...
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Destination News: Winter 2020
Wednesday, February 05, 2020, 1pm
City of Raleigh issues RFI for 500+ room convention hotel
More hotel rooms are coming to downtown Raleigh's convention campus! The City of Raleigh has released a Request for Information (RFI) for an upper upscale, full-service convention hotel and a separate office/mixed-use building on two city-owned, prime vacant lots. The goal of the RFI is to seek interested developers for the hotel and office/mixed-use sites.
Located at the end of Fayetteville St. in the heart of downtown Raleigh, the sites are located across from the Raleigh Convention Center and Duke Energy Center for the Performing Arts as illustrated below.
“We are delighted to soon be able to offer an additional 500+ rooms to Raleigh’s hotel package,” said Raleigh Convention Center director/general manager Kerry Painter, CFE, CEM, CMP. “Located within two blocks of the 500,000-square-foot Raleigh Convention Center—these rooms will change the face of Raleigh’s convention possibilities and bring a new look to our city and an engaging, vibrant experience for our clients and their attendees.”
Thanksgiving and December travel breaks RDU passenger records
RDU International Airport continues to attract record travelers from all over the country. Over the Thanksgiving holiday, on Sun., Dec. 1, RDU experienced its highest-ever recorded passenger volume in a day, with more than 54,800 holiday travelers. Normally, massive crowds make for massive waits, but this wasn't the case at RDU over the holidays. One hundred percent of passengers waited less than 30 minutes to get through the security checkpoint, and 95% waited less than 15 minutes. RDU continues to maintain a quality travel experience for its visitors while undergoing some of the biggest increases in volume in its history in 2019.
Over the course of the past year, RDU has added more than 23 new routes to five new cites as well as welcoming Spirit Airlines as RDU's 10th airline. You can read more about RDU's 2019 accolades here.
A year of BBQ in Raleigh, N.C.
The BBQ scene is taking over in Raleigh in 2020. Five new BBQ spots are set to open their doors in the Raleigh area over the year.
- Longleaf Swine BBQ: At Transfer Co. Food Hall—Raleigh's massive new foodie attraction—Longleaf Swine is bringing all the smoked meat eats to their first brick-and-mortar location early this year. First started as a food trailer in 2016, the locally-loved 'cue truck is a partnership between Adam Cunningham and Marc Russell.
- The Preserve BBQ: "The Pitmaster" himself Ed Mitchell is bringing a new BBQ spot to Raleigh and is set for a spring 2020 opening.
- Wyatt’s Whole Hog Barbecue: Known as one of the top rated pitmasters in the state, Wyatt Dickson plans to open his new spot in fall 2020, serving up genuine Eastern-style Carolina BBQ.
- Sam Jones BBQ: Renowned fourth-generation pitmaster and James Beard Award semifinalist Sam Jones is bringing his famous Eastern-style barbecue to downtown Raleigh in late 2020.
- PRIME Barbecue: After years of the traveling the country looking to perfect the best BBQ, pitmaster Chris Prieto has achieved what he calls “BBQ excellence” and will opening PRIME in Knightdale in early 2020.
Downtown Raleigh's Longleaf Hotel is now open!
The 57-room, boutique-style Longleaf Hotel in downtown Raleigh just opened for business. Renovated from the ground up, the Longleaf manages to hold on to the character of the vintage motor lodge it once was. In fact, many of the mid-century details of the original hotel, like its iconic starshine decorative blocks, were uncovered and highlighted in the remodel. With a delightful mix of old and new, the hotel strikes a slightly nostalgic-yet-modern tone. The property is located just a few blocks north of the North Carolina State Capitol, within walking distance to nightlife in the Glenwood South District plus museums including the North Carolina Museum of Natural Sciences and North Carolina Museum of History.
Meeting space options are available, including the The Longleaf Lounge, which features a patio and indoor space available for rent.
Even more hotels coming soon:
- The seven-story, 126-room, boutique Origin Hotel (rendering below) will open early 2020. The property will be located between the Glenwood South and Warehouse Districts in downtown Raleigh, and it will also include a wine and tapas restaurant.
- Montfort Hall is currently being renovated and restored to be a 10-room boutique inn and gathering space. It was created from an 1858 Italianate-style historic mansion in the Boylan Heights neighborhood in downtown Raleigh. This National and Raleigh Historic Landmark is one of the few remaining pre-civil war houses in the area and is estimated to open in 2020.
- The Gables is an old motor lodge in downtown Raleigh that’s being renovated into a boutique motel by Raleigh native and Grammy-nominated folk singer Tift Merrit and Daniel Robinson (who developed the Durham Hotel). It’s currently under construction and will have 19 guest rooms and a lounge.
- A more than 120-room boutique hotel, The Willard, will be an urban-style AC Hotel by Marriott. This property will be located in the Glenwood South district and is estimated to open in late 2021.
90 of the biggest events and festivals in Raleigh, N.C., in 2020
Have big plans for 2020? So do we!
A year full of major festivals and celebrations lies ahead in Raleigh, N.C., showcasing talent, creativity and culture, delicious foods and beverages (and some surprises, too!). We've pulled together 90 of the biggest events we're looking forward to this year—take a look and save some dates!
New year, new look—the Raleigh Convention Center is getting a makeover
It’s a new year, and the Raleigh Convention Center is preparing for a refresh of its interior spaces! 2020 will bring a vibrant, new meeting and event experience for clients and attendees. Modern, comfortable furniture will invite attendees to engage, collaborate and recharge, while updated paint, finishes and carpeting will lend a creative sophistication to every event’s ambiance. Stay tuned for more updates and a sneak peek at the center’s stunning new palette by following their Instagram, Twitter and Facebook accounts.
Dreamville Festival/"biggest events" photo: Garrett Poulos


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From Ohio History Central
The Wyandot Indians originally lived in southern Ontario. They were also called Hurons. But they called themselves "wendat" which in time became "Wyandot" or "Wyandotte." They were related to the Iroquois Indians. But in the years before European settlement, the Iroquois Confederacy attacked them and drove them from their homeland. Some came to live in northern Ohio. They built their main villages in Wyandot, Marion, and Crawford Counties, but they lived across northern Ohio and as far south as Ross County.
The Wyandots had a special friendship with the Shawnee Indians. They referred to the Shawnee tribe as their "nephew" or "younger brother." Other Indian tribes could be allies one day and enemies the next. Political alliances changed with the times.
Tarhe and Leatherlips were notable leaders of the Wyandot Indians.
[[Category:Exploration To Statehood]]

domain: geography


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Join 2019 National Book Award Winner Susan Choi (Trust Exercise) and 2022 National Book Award Finalist Sarah Thankam Mathews (All This Could Be Different) for a conversation on the impact of contemporary bildungsroman and what it means to grow up in adult fiction. Choi and Mathews read from their novels and discuss how and why coming-of-age stories capture writers and readers alike.
Moderated by Ruth Dickey, Executive Director of the National Book Foundation.
Presented in partnership with the Association of Writers & Writing Programs.
(Thursday) 12:10 pm CST
Kansas City Convention Center (Ballroom A, Level 2)
Kansas City, MO


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Market Bulletin (15/08/2017)
Wednesday marked ten years since the beginning of the global financial crisis, and its consequences continue to be felt on markets and in politics to this day. Indeed, the crisis was so momentous that commentators tend to divide recent economic history into the ‘pre-crisis’ and ‘post-crisis’ eras.
Yet the world’s focus on Wednesday morning was, perhaps understandably, elsewhere. North Korea responded to US-led sanctions by promising “thousands-fold” revenge on the country. Speaking to press on Tuesday, Donald Trump had warned that the US would meet North Korea’s nuclear threats with “fire and fury, the like of which the world has never seen”. North Korea responded by saying it would conduct a missile test close to Guam, a US territory (and military base) in the western Pacific.
Such inflammatory rhetoric is par for the course among North Korean leaders. It is much less common among US presidents. The fact that Trump’s words closely resembled those of Harry Truman in 1945 was hardly comforting. After the US had dropped an atomic bomb on Hiroshima, and before it dropped a still more potent one on Nagasaki, Truman told the camera: “They [the Japanese] may expect a rain of rack and ruin from the air, the likes of which has never been seen on this earth.”
Pundits and investors alike are increasingly at ease with the former real estate magnate’s negotiating strategy in other areas of politics. But ‘bidding high’ in talk about nuclear weapons is a little different, especially now that North Korea claims to have finally completed building a fully-functioning intercontinental ballistic missile. Jeffrey Lewis, director of the East Asia Nonproliferation Program in Monterey, California, is clearly convinced. “That’s done. We’re there. North Korea can put a nuclear weapon on New York City,” he said last week. Other experts were more guarded.
Markets suffered as a result. Japan’s Topix and South Korea’s Kospi indices took significant hits, while the S&P 500 ended the five-day period down 1.34%. Purchases of ‘safe-haven’ assets such as gold, Bunds and Swiss francs rose. Perhaps most significantly, the VIX (which measures volatility on the S&P 500) jumped more than 50% to reach its highest level this year.
US losses might have been greater were it not for earnings season. Three sectors dominated: energy, which has been buoyed by a higher oil price; finance, which benefits from rising interest rates (and, in the US at least, from much-improved balance sheets); and technology, which accounts for 23% of the S&P 500. These three sectors alone accounted for 70% of earnings growth in the latest quarterly round among S&P 500 companies. While reduced consumer spending has provided a headwind for some of the major brands, such as those owned by Procter & Gamble, a weakening dollar has buoyed corporate profits more broadly.
In fact, the S&P 500 has posted dozens of record closes this year. It is this kind of success – together with the historically low yields on both sovereign and corporate bonds – that has led some analysts to worry whether markets are in a bubble and another financial crisis might be in the offing. Yet there are good reasons to think not. It was a crash in the US housing market that triggered the last financial crisis and, as a report published last week by Capital Economics pointed out, US house prices today are not stretched; the ratio of mortgage lending to disposable income is far, far healthier than in 2007; banks have tightened their lending criteria; and there are far fewer houses coming onto the market. The so-called NINJA (no income, no job or assets) mortgage loans so common in 2007 are no longer freely available. Moreover, on Friday Nationwide released figures which showed that its buy-to-let UK mortgage lending fell by half in the second quarter – last year’s Stamp Duty increase, this year’s tax relief cut, and falling rents were all reckoned to have played a part.
Nevertheless, the crisis offers plenty of salutary lessons to today’s investor. Charlie Geller was one of the few investors to see the crisis coming. In The Big Short, the Oscar-winning film based on the book about the crisis, Geller’s character explained: “Our investment strategy was simple. People hate to think about bad things happening so they always underestimate their likelihood.” It is a warning worth heeding in all markets – there is no substitute for looking closely at a company’s balance sheet, and understanding where the risks lie.
However, just because people aren’t borrowing too much to buy houses any more doesn’t mean that they’ve learnt how to save properly. Alistair Darling, UK chancellor when the crisis was at its peak, used the crisis anniversary to warn that rising consumer debt should “raise alarm bells” over the UK’s economic outlook.
A report released last week by the Social Market Foundation would suggest that he is right to be worried. It showed that 14.4 million working-age adults in the UK are not saving at all, while 26.5 million do not hold adequate asset balances in either ‘rainy day’ or pension savings. Moreover, too many of those who do save fail to allocate their money wisely – 6.8 million hold more money in cash than needed to cover emergency costs. Yet money left in instant access cash accounts over the past five years would have lost 4% in value due to inflation, the report found. Had that money been invested evenly across the FTSE 100, however, it would have gained 47% over the same period.
Figures released by Visa last week showed UK consumer spending falling in July for the third consecutive month – the longest contraction in more than four years. Meanwhile, estimates showed the UK economy slowing again, as a weak pound failed to boost exports. Manufacturing output was flat in June and the trade deficit widened to £4.6 billion – the biggest this year. On the other hand, a survey by Markit showed that UK employers are hiring staff via recruitment agencies at the fastest rate in two years. The biannual Boardroom Bellwether, published last week, showed that two thirds of FTSE 350 companies believed political risk in the UK was rising, against just 40% last December.
Corporate earnings announcements in the UK last week offered similarly varied signals. G4S, a security services firm, and Rupert Murdoch’s News Corp both saw their stock prices sink on poor results. Meanwhile, Worldpay, a UK payments processing company, revealed that it will be bought by the American company Vantiv, creating the largest payments processor in the world.
Stocks in the UK, as in much of the world, suffered in part due to tensions over North Korea, but corporate factors were also significant, pushing the FTSE 100 down 2.69% to a three-month low, as financial, energy and mining stocks slipped; the Eurofirst 300 ended down 2.78% and the Nikkei 225 fell 1.12%.
Continental European stocks were afflicted by mixed corporate earnings and concerns over the outlook for debt. Figures last week showed that Italian banks’ holdings of domestic sovereign debt fell by the largest amount on record in June, and central banks continue to increase bond purchases to plug the gap. The ECB is expected to make a tightening announcement in the coming weeks, but in many ways the market has yet to be let off life support. Ten years after it began, the global financial crisis continues to loom large over the world economy.
The information contained is correct as at the date of the article. The information contained does not constitute investment advice and is not intended to state, indicate or imply that current or past results are indicative of future results or expectations. Where the opinions of third parties are offered, these may not necessarily reflect those of St. James’s Place.
FTSE International Limited (“FTSE”) © FTSE 2017. “FTSE®” is a trade mark of the London Stock Exchange Group companies and is used by FTSE International Limited under licence. All rights in the FTSE indices and/or FTSE ratings vest in FTSE and/or its licensors. Neither FTSE nor its licensors accept any liability for any errors or omissions in the FTSE indices and/or FTSE ratings or underlying data. No further distribution of FTSE Data is permitted without FTSE’s express written consent.
The ‘St. James’s Place Partnership’ and the titles ‘Partner’ and ‘Partner Practice’ are marketing terms used to describe St. James’s Place representatives.
Members of the St. James’s Place Partnership in the UK represent St. James’s Place Wealth Management plc, which is authorised and regulated by the Financial Conduct Authority.
St. James’s Place Wealth Management plc Registered Office: St. James’s Place House, 1 Tetbury Road, Cirencester, Gloucestershire, GL7 1FP.
Registered in England Number 4113955


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by Dave Hughes
First of all, let me admit a bias. As a trombonist, there are few sounds more beautiful to my ears than an ensemble of trombones. Combine this with another passion, the seductive throbbing of cuban percussion, and you have a combination that's tough to beat. Manny Oquendo and Libre live up to this potential on their latest Milestone outing, Ahora. Most of the program is spirited yet polished. While it's not the most extroverted Cuban dance or party music you'll ...read more


text:
Corticosteroids for systemic use. Glucocorticoids. Dexamethasone
Dexamethasone should be administered intravenously or intramuscularly in urgent cases and when oral administration is impossible in:
- Diseases of the endocrine system
- Rheumatic diseases (as an adjuvant therapy in the period when the main therapy did not work, that is, in patients in whom the analgesic and anti-inflammatory effects of non-steroidal anti-inflammatory drugs were unsatisfactory)
- Skin diseases
- Allergic diseases (not curable by traditional treatment)
- Eye diseases
- Gastrointestinal diseases
- Diseases of the respiratory tract
- Hematological diseases
- Kidney diseases
- Malignant oncological diseases
- Edema of the brain
Ministry of Health of Ukraine
21.03.2019 № 629
for medical use of a medicinal product
Qualitative and quantitative composition:
Active substance: dexamethasone;
1 ml of solution contains 4 mg of dexamethasone sodium phosphate;
List of excipients: sodium hydrogen phosphate dodecahydrate, potassium dihydrogen phosphate, glycerin, benzyl alcohol, disodium edetate (Trilon B), water for injections.
Pharmaceutical form. Solution for injection.
Main physical and chemical properties: clear colorless liquid.
Pharmacotherapeutic group: Corticosteroids for systemic use. Glucocorticoids. Dexamethasone. ATC Code H02A B02.
Dexamethasone-Darnitsa is a synthetic adrenal cortex hormone (corticosteroid) that has a glucocorticoid effect. It has anti-inflammatory and immunosuppressive effects, and also affects energy metabolism, glucose metabolism and (through negative relationship) on the secretion of the factor activating the hypothalamus and trophic hormone of the adenohypophysis.
The mechanism of action of glucocorticosteroids is still not fully understood. A sufficient amount of data on the mechanism of action of glucocorticosteroids has now been obtained to confirm that they act at the cellular level. There are two well-studied receptor systems in the cytoplasm of cells. Through binding to glucocorticoid receptors, glucocorticosteroids exert anti-inflammatory and immunosuppressive effects and regulate glucose metabolism, and due to binding to mineralocorticoid receptors, they regulate sodium, potassium metabolism and water-electrolyte balance.
Glucocorticosteroids dissolve in lipids and easily penetrate into target cells through the cell membrane. The binding of the hormone to the receptor leads to a change in the conformation of the receptor, which contributes to an increase in its affinity with DNA. The hormone/receptor complex enters the cell nucleus and binds to the regulatory center of the DNA molecule, also called the glucocorticoid response element (GRE). An activated receptor, associated with GRE or with specific genes, regulates mRNA transcription, which can be increased or decreased. The newly formed mRNA is transported to the ribosomes, after which new proteins are formed. Depending on the target cells and the processes occurring in the cells, protein synthesis can be increased (for example, the formation of tyrosine transaminase in liver cells) or decreased (for example, the formation of IL-2 in lymphocytes). Since glucocorticosteroid receptors are found in all types of tissues, it can be assumed that glucocorticosteroids act on most cells in the body.
Dexamethasone is rapidly absorbed from the injection site. The maximum concentration in blood plasma is reached within the first 5 minutes with intravenous administration and within 1 hour with intramuscular administration.
After local administration to the joint or soft tissues (inflammation focus), absorption is slower than in the case of injection.
With intravenous administration, the onset of action is immediate, with intramuscular administration - after 8 hours.
The medicinal product belongs to the long-acting glucocorticosteroids. The action lasts 17-28 days after intramuscular injection and from 3 days to 3 weeks after topical injection.
In the blood plasma, 77 % of dexamethasone binds to plasma proteins, mainly to albumin. Only a small amount of dexamethasone binds to other proteins. Dexamethasone is fat-soluble, so it freely penetrates into cells and intercellular space. In the central nervous system (hypothalamus, pituitary gland), it binds to and acts through membrane receptors. In peripheral tissues, it binds and acts through cytoplasmic receptors.
Dexamethasone metabolism occurs at the site of action, that is, in the cell itself. Dexamethasone is primarily metabolized in the liver, possibly also in the kidneys and other tissues.
The biological half-life of dexamethasone is 24–72 hours. About 80% of the administered dexamethasone is eliminated by the kidneys in the form of glucuronide within 24 hours.
Dexamethasone is administered intravenously or intramuscularly in urgent cases and when oral administration is impossible.
Endocrine system diseases:
- replacement therapy of primary or secondary (pituitary) adrenal insufficiency (except for acute adrenal insufficiency, in which hydrocortisone or cortisone are more appropriate, given their more pronounced hormonal effect);
- acute adrenal insufficiency (hydrocortisone or cortisone are the medicinal products of choice; concomitant use with mineralocorticoids may be necessary, especially when using synthetic analogs);
- before surgery and in cases of serious injury or illness in patients with established adrenal insufficiency or with undetermined adrenocortical reserve;
- shock resistant to traditional therapy, with existing or suspected adrenal insufficiency;
- congenital adrenal hyperplasia;
- non-suppurative inflammation of the thyroid gland and severe forms of radiation thyroiditis.
Rheumatological diseases (as an adjunct therapy during the period when the basic therapy did not work, that is, in patients whose analgesic and anti-inflammatory effects of nonsteroidal anti-inflammatory drugs were unsatisfactory):
- rheumatoid arthritis, including juvenile rheumatoid arthritis and extra-articular manifestations of rheumatoid arthritis (rheumatic lungs, changes in the heart, eyes, cutaneous vasculitis);
- synovitis with osteoarthritis; post-traumatic osteoarthritis; epicondylitis; acute nonspecific tendosynovitis; acute gouty arthritis; psoriatic arthritis, ankylosing spondylitis; systemic connective tissue diseases; vasculitis.
- pemphigus; severe erythema multiforme (Stevens-Johnson syndrome); exfoliative dermatitis; bullous dermatitis herpetiformis; severe forms of exudative erythema; nodal erythema; severe forms of seborrheic dermatitis; severe psoriasis; hives that do not respond to standard treatment; fungoid mycosis; dermatomyositis.
Allergic diseases (not amenable to traditional treatment):
- bronchial asthma; contact dermatitis; atopic dermatitis; serum sickness; chronic or seasonal allergic rhinitis; allergy to medicines; urticaria after blood transfusion.
Diseases of the organs of vision:
- inflammatory diseases of the eyes (acute central choroiditis, optic neuritis); allergic diseases (conjunctivitis, uveitis, scleritis, keratitis, iritis); systemic immune diseases (sarcoidosis, temporal arteritis); proliferative changes in the orbit (endocrine ophthalmopathy, pseudotumour); immunosuppressive therapy for corneal transplant. The solution can be administered systemically or locally (administration under the conjunctiva and retrobulbar or parabulbar administration).
- to remove the patient from the critical period with: ulcerative colitis (severe development), Crohn's disease (severe development); chronic autoimmune hepatitis; rejection reaction in liver transplant.
Respiratory tract diseases:
- symptomatic sarcoidosis (symptomatic); acute toxic bronchiolitis; chronic bronchitis and asthma (with exacerbation); focal or disseminated pulmonary tuberculosis (together with appropriate anti-tuberculosis therapy); beryllium disease (granulomatous inflammation); radiation or aspiration pneumonitis.
- acquired or congenital chronic aplastic anemia; autoimmune hemolytic anemia;
- secondary thrombocytopenia in adults; erythroblastopenia; acute lymphoblastic leukemia (induction therapy); idiopathic thrombocytopenic purpura in adults (intravenous administration only — intramuscular administration is contraindicated).
- immunosuppressive therapy for kidney transplantation; stimulating diuresis or reducing proteinuria in idiopathic nephrotic syndrome (without uremia) and impaired renal function in systemic lupus erythematosus.
Malignant oncological diseases:
- palliative treatment of leukemia and lymphoma in adults; acute leukemia in children; hypercalcemia in malignant diseases.
- cerebral edema due to a primary or metastatic brain tumor; craniotomy and craniocerebral trauma.
- shock that does not respond to classical treatment; shock in patients with adrenal insufficiency; anaphylactic shock (intravenously after adrenaline administration); before surgery to prevent shock if adrenal insufficiency is suspected or established.
Other therapeutic indications:
- tuberculous meningitis with subarachnoid blockade (together with appropriate anti-tuberculosis therapy); trichinosis with neurological symptoms or trichinosis of the myocardium; cystic swelling of the aponeurosis or tendon (ganglion).
Indications for intra-articular or soft tissue injection:
- rheumatoid arthritis (severe inflammation of an individual joint); ankylosing spondylitis (when inflamed joints do not respond to conventional treatment); psoriatic arthritis (oligoarticular form and tendovaginitis); monoarthritis (after evacuation of synovial fluid); osteoarthritis of the joints (only in the case of synovitis and exudation); extra-articular rheumatism (epicondylitis, tendovaginitis, bursitis); acute and gouty arthritis.
Local administration (introduction to the lesion site)
- keloid lesions; hypertrophic, inflammatory and infiltrated lesions in lichen, psoriasis, granuloma annularis, sclerosing folliculitis, discoid lupus and cutaneous sarcoidosis; disc lichen planus; Urbach-Oppenheim disease; localized alopecia.
- Hypersensitivity to the active substance or to other components of the medicinal product.
- Acute viral, bacterial or systemic fungal infections (if not used properly).
- Vaccination with live vaccine.
- Itsenko-Cushing's syndrome.
- Intramuscular administration is contraindicated in patients with severe diseases of the blood coagulation system.
- In the case of topical application - bacteremia, systemic fungal infections, infections at the site of application, including septic arthritis due to gonorrhea or tuberculosis, use in patients with unstable joints.
Interaction with other medicinal products and other forms of interaction
With the simultaneous use of the medicinal product with other drugs, the following interactions are possible:
with medicinal products that inhibit the CYP 3A4 enzyme (for example, ketoconazole, macrolide antibiotics) - an increase in the concentration of dexamethasone in the blood plasma; ketoconazole can inhibit the adrenal synthesis of glucocorticosteroids, thus, due to a decrease in the concentration of dexamethasone, adrenal insufficiency may develop;
with aminoglutethimide, ephedrine, inhibitors of adrenal cortex function (for example, mitotan), carbamazepine, primidone, rifampicin, rifabutin, phenobarbital, phenytoin - a decrease in the effectiveness of dexamethasone, while the use of medicinal products should increase the dose of dexamethasone;
with azathioprine, antipsychotics, other glucocorticosteroids, carbutamide - an increased risk of developing cataracts;
with albendazole, heparin, potassium diuretics, cyclosporine - an increase in the effectiveness of the latter, with the simultaneous use of cyclosporine and glucocorticosteroids, seizures may occur;
with amphotericin B, β2-adrenergic agonists, drugs that remove potassium from the body (for example, diuretics) - an increased risk of hypokalemia, which can lead to heart failure, while the use of amphotericin B and glucocorticosteroids also increases the risk of osteoporosis;
with antihypertensive drugs, natriuretics, praziquantel, hypoglycemic agents, salicylates, somatropin (in high doses) - a decrease in the effectiveness of the latter; with the simultaneous use of dexamethasone and salicylates, the dose of dexamethasone should be reduced with caution, since this may result in an increase in the concentration of salicylates in the blood plasma and intoxication;
with antihistamines, m-anticholinergics, nitrates, tricyclic antidepressants - the risk of increased intraocular pressure; with the simultaneous use of tricyclic antidepressants and glucocorticosteroids, the risk of depression also increases;
with anticholinesterase agents - an increased risk of developing severe weakness in patients with myasthenia gravis;
with vitamin D - weakening the effect of the latter on the absorption of calcium from the intestine;
with thyroid hormones - increasing the clearance of glucocorticosteroids;
with isoniazid, mexiletine - a decrease in the concentration of the latter in blood plasma due to an increase in their metabolism;
with immunosuppressants - an increased risk of developing infections, lymphoma or other lymphoproliferative disorders associated with the Epstein-Barr virus;
with carbonic anhydrase inhibitors - an increase in the risk of developing osteoporosis;
with indomethacin - intensification of the toxic effects of dexamethasone (due to its displacement from the connection with albumin);
with live antiviral vaccines and against the background of other types of immunization - increased risk of virus activation and the development of infections;
with coumarin anticoagulants - a change in the action of the latter, while the use of medicinal products should be monitored for prothrombin time;
with muscle relaxants - increasing the severity and duration of muscle blockade against the background of hypokalemia caused by glucocorticosteroids;
with non-steroidal anti-inflammatory drugs, ethanol - increased risk of gastrointestinal bleeding and ulceration;
with paracetamol - increased risk of developing the hepatotoxic effect of paracetamol due to the induction of "liver" enzymes and the formation of its toxic metabolite;
with medicinal products that are metabolized by CYP 3A4 (indinavir, erythromycin) - a decrease in the concentration of the latter due to an increase in their clearance;
with rithordinum - the development of pulmonary edema is possible; a fatal outcome for a woman in labor was reported due to the development of such a condition; the simultaneous use of rithordine and dexamethasone is contraindicated during childbirth;
with cardiac glucosides - the risk of heart rhythm disturbance in patients with hypokalemia and increased toxic effects of glucocorticosteroids;
with steroid hormonal drugs (for example, androgens, anabolics, estrogens, oral contraceptives) - the appearance of acne and hirsutism; estrogens, oral contraceptives enhance the therapeutic and toxic effects of glucocorticosteroids, reducing their clearance;
with thalidomide - an increased risk of developing toxic epidermal necrolysis.
Ergocalciferol and parathyroid hormone prevent the development of osteopathy caused by glucocorticosteroids.
Interactions with Therapeutic Benefits: Co-administration of dexamethasone and metoclopramide, diphenhydramine, prochlorperazine, or 5-HT3 receptor antagonists (serotonin or 5-hydroxytryptamine receptor type 3, such as ondansetron or granisetron) is effective in preventing the nausea and vomiting caused by cysplathymy therapy cyclophosphamide, methotrexate, fluorouracil.
Interaction with dexamethasone and all of the aforementioned drugs may distort the dexamethasone suppression test. This should be taken into account when evaluating the test results.
Antacids reduce the absorption of dexamethasone in the stomach. The effect of dexamethasone when taken simultaneously with food and alcohol has not been studied, however, the simultaneous use of drugs and food with a high sodium content is not recommended.
Smoking does not affect the pharmacokinetics of dexamethasone.
Special warnings and precautions for use.
Before and during glucocorticosteroid therapy, it is necessary to carry out a complete blood count, monitor the level of glycaemia and the content of electrolytes in the blood plasma.
During treatment with dexamethasone (especially long-term), it is necessary to observe an ophthalmologist, control blood pressure and water-electrolyte balance, in particular the level of potassium in the blood serum, as well as the picture of peripheral blood and the level of glycaemia.
During parenteral treatment with corticosteroids, hypersensitivity reactions may occur in isolated cases, therefore, appropriate measures must be taken before starting treatment with dexamethasone, given the possibility of allergic reactions (especially in patients with a history of allergic reactions to any other medicinal products).
Withdrawal of the medicinal product in the case of long-term treatment, it is possible to develop a withdrawal syndrome (without visible signs of adrenal insufficiency) with the following symptoms: fever, runny nose, redness of the conjunctiva, headache, dizziness, drowsiness or irritability, lethargy, muscle and joint pain, nausea, vomiting, weight loss, general weakness, convulsions. In this regard, the dose of dexamethasone should be reduced gradually. Sudden discontinuation of use of the medicinal product can be fatal.
If the patient is under severe stress (due to trauma, surgery or serious illness) during therapy or after discontinuation of dexamethasone therapy, the dose should be increased or hydrocortisone or cortisone should be used.
Patients who have been using dexamethasone for a long time and are experiencing severe stress after stopping therapy should resume taking dexamethasone, since the caused adrenal insufficiency can continue for several months after stopping treatment.
Treatment with dexamethasone or natural glucocorticosteroids can mask symptoms of an existing or new infection, as well as symptoms of intestinal perforation. During treatment, contact with people with colds or other infections should be avoided.
Dexamethasone can cause exacerbation of systemic fungal infection, latent amebiasis and pulmonary tuberculosis.
Patients with active pulmonary tuberculosis should receive dexamethasone (along with anti-tuberculosis drugs) only for rapid or disseminated pulmonary tuberculosis. Patients with inactive pulmonary tuberculosis who are being treated with dexamethasone, or patients who are responding to tuberculin, should receive chemical prophylaxis.
Vaccination with live vaccine is contraindicated at dexamethasone treatment. Vaccination with a non-live viral or bacterial vaccine does not lead to the expected development of antibodies and does not give the expected protective effect. Do not prescribe Dexamethasone 8 weeks before vaccination and start using no earlier than 2 weeks after vaccination.
The medicinal product should be prescribed with caution to infectious patients, especially with chickenpox and measles, since these diseases with the use of dexamethasone proceed in a more severe form. Therefore, persons who have not had these diseases should be careful to exclude infection as much as possible. In case of contact with patients, you should immediately consult a doctor. Prophylactic treatment with immunoglobulin is recommended.
Glucocorticosteroids should be used with caution in patients with blistering eyes herpes (herpes simplex), as their use can lead to corneal perforation.
Caution and medical supervision are recommended for patients with osteoporosis, arterial hypertension, heart failure, tuberculosis, glaucoma, hepatic or renal failure, diabetes mellitus, gastritis, esophagitis, diverticulitis, active peptic ulcer, with recent intestinal anastomosis, colitis and epilepsy (III-IV degree), nephrourolithiasis, hyperlipidemia, poliomyelitis (except for the form of bulbar encephalitis), hypoalbuminemia and patients in conditions leading to its occurrence, patients with immunodeficiency conditions (including AIDS or HIV infection), lymphadenitis after BCG vaccination.
Patients require special care in the first weeks after myocardial infarction, patients with thromboembolism, severe myasthenia gravis, hypothyroidism, psychosis or psychoneurosis, as well as elderly patients.
During treatment with dexamethasone, an exacerbation of diabetes mellitus or a transition from the latent phase to clinical manifestations may occur.
The effect of glucocorticosteroids is enhanced in patients with liver cirrhosis or hypothyroidism.
Patients with a violation of the water-electrolyte balance should be careful when taking dexamethasone, since medium and large doses of glucocorticosteroids can cause salt and fluid retention in the body, as well as increased potassium excretion. In these cases, restriction of salt intake and additional intake of potassium are indicated. All corticosteroids enhance the process of calcium excretion, as a result of which the secretion of mineralocorticoids can be impaired. Therefore, an additional appointment of salt and/or mineralocorticoids is indicated.
Long-term use of glucocorticosteroids can lead to the development of posterior subcapsular cataract, glaucoma, with damage to the optic nerve, and also increases the risk of secondary viral or fungal eye infections.
Caution is advised in patients recovering from surgery or bone fracture, as dexamethasone can slow wound healing and bone formation.
Special attention should be paid to the use of systemic glucocorticosteroids in patients with severe affective disorders, including depressive, manic-depressive psychosis, previous steroid psychosis, including patients with such disorders. Patients and/or caregivers should be warned of the possibility of serious psychiatric side effects. Symptoms usually appear within days or weeks after starting treatment. The risk of these side effects is higher with high doses. Most reactions resolve with dose reduction or medicinal product withdrawal, although specific treatment is sometimes necessary.
It is necessary to monitor and timely identify changes in the mental state, especially depressed mood, suicidal thoughts and intentions. Corticosteroids should be used with extreme caution in patients with a history of affective disorders, especially in patients with a history of allergic reactions to any other medications, as well as in close relatives. If these symptoms develop, you should consult a doctor. Also, mental disorders can be observed with the abolition of glucocorticosteroids.
Glucocorticosteroids may interfere with the results of allergic skin tests.
Children should only be treated with dexamethasone when clearly needed. During treatment with dexamethasone, careful monitoring of the growth and development of children is necessary.
There is evidence of long-term neurological side effects after early treatment (<96 hours) of premature infants with chronic lung disease at initial doses of 0.25 mg/kg twice daily.
Intra-articular use of the medicinal product can lead to local or systemic adverse reactions. Frequent use can cause cartilage damage or bone necrosis.
Before intra-articular administration of dexamethasone, the synovial fluid should be removed from the joint and examined (check for infection). Do not administer the medicine to patients with infected joints. If a joint infection develops after the injection, proper antibiotic therapy should be started.
Frequent intra-articular injections can injure the joint tissue. During treatment, patients should avoid excessive loads on the damaged joints until the inflammatory process disappears completely, even when symptomatic improvement occurs.
The use of the medicinal product should be discontinued in patients who, with intra-articular administration of glucocorticosteroids, have significantly increased pain, which is accompanied by swelling and further limitation of joint mobility, fever and general malaise (these symptoms indicate the occurrence of septic arthritis). If septic arthritis develops and the diagnosis of sepsis is confirmed, appropriate antibiotic therapy should be prescribed.
List of excipients
The medicinal product contains less than 1 mmol of sodium (23 mg) per Dose therefore, it is practically free of sodium.
Fertility, pregnancy and lactation.
Glucocorticosteroids cross the placenta and reach high concentrations in the fetus. A harmful effect on the fetus and newborn baby cannot be ruled out. Dexamethasone inhibits the intrauterine development of the child. According to some reports, even pharmacological doses of glucocorticosteroids increase the risk of placental insufficiency, oligohydramnios, retarded fetal development or intrauterine death, an increase in the number of leukocytes (neutrophils) in the fetus and adrenal insufficiency. There are no data on the teratogenic effect of dexamethasone. Children born to mothers who have been prescribed glucocorticosteroids during pregnancy should be carefully screened for adrenal insufficiency.
The medicinal product should be used in urgent cases when the expected benefit to the expectant mother outweighs the potential risk to the fetus.
Extra caution is advised for preeclampsia. It is generally recommended that the lowest effective dose be used during pregnancy with glucocorticosteroids to control the underlying disease.
Women who have used glucocorticosteroids during pregnancy are advised to take additional doses of them during labor. In the case of prolonged labor or planning a caesarean section, 100 mg of hydrocortisone is recommended every 8 hours.
The medicinal product is contraindicated during lactation (except in urgent cases).
Glucocorticosteroids pass into breast milk. In the case of the use of dexamethasone, especially at a dose higher than physiological norms (about 1 mg), breastfeeding is not recommended, since this can lead to a slowdown in the growth of the child and a decrease in the secretion of endogenous corticosteroids.
Effects on ability to drive and use machines
There are no data, however, the possibility of the development of adverse reactions from the nervous system and organs of vision should be taken into account.
Posology and method of administration.
The medicinal product should be used for adults and children from birth.
Administered intravenously (as an injection or infusion), intramuscularly or locally - using intra-articular injections or injections into the lesion site on the skin or into the soft tissue infiltrate. Use 0.9% sodium chloride solution or 5% glucose solution as a solvent for infusion.
When used in infants, especially premature babies, solutions intended for intravenous administration or further dissolution of the drug should not contain preservatives.
When mixing a medicinal product with a solvent for infusion, aseptic rules should be observed. The mixture should be applied within 24 hours, as infusion solutions usually do not contain preservatives.
Medicines for parenteral administration should be visually inspected for impurities and discoloration each time before administration.
The dose of the medicinal product should be determined individually, in accordance with the disease of a particular patient, the prescribed period of treatment, the tolerance of glucocorticosteroids and the body's response.
The medicinal product should be administered parenterally in urgent cases when oral therapy is not possible, and in the cases specified in the "Therapeutic indications" section.
Intravenous and intramuscular administration.
The medicinal product should be used in an initial dose of 0.5 to 9 mg/day, if necessary, the dose can be increased.
Initial doses of dexamethasone should be used until a clinical response occurs, and then the dose should be gradually reduced to the lowest clinically effective. If high doses are used over a period longer than a few days, the dose should be reduced gradually over the next few days or even over a longer period.
Usually the medicinal product is used in a dose of 0.2–6 mg, in particular:
- large joints (for example, knee) - 2-4 mg;
- small joints (for example, interphalangeal, temporomandibular) - 0.8-1 mg;
- bursa synovial - 2-3 mg;
- tendon sheaths - 0.4–1 mg;
- infiltration of soft tissues - 2–6 mg;
- ganglia - 1-2 mg.
Re-administration into the joint is possible after 3-4 months. The administration can be performed 3 or 4 times in one joint throughout life. More frequent intra-articular injection can damage articular cartilage and cause bone necrosis. Intra-articular injections are recommended for no more than 2 joints at a time.
The dose of dexamethasone injected into the site of injury is equal to the intra-articular dose. It is recommended to inject dexamethasone into no more than 2 lesions at the same time.
Intra-articular injections of glucocorticosteroids can lead to the development of systemic reactions in addition to local ones.
Intra-articular administration of glucocorticosteroids into infected joints and unstable or deformed joints should be avoided.
Substitution therapy: the medicinal product is used at a dose of 0.02 mg/kg body weight (0.67 mg/m2 body surface area) per day for 3 injections, or 0.008-0.01 mg/kg body weight (0.2-0.3 mg/m2 body surface area).
Other therapeutic indications: the medicinal product should be used at a dose of 0.02–0.1 mg/kg (0.8–5 mg/m2 of body surface area) every 12–24 hours.
For comparison, the equivalent doses of various glucocorticosteroids in milligrams are given below:
Dexamethasone 0.75 mg
Prednisone 5 mg
Cortisone 25 mg
Methylprednisolone 4 mg
Hydrocortisone 20 mg
Triamcinolone 4 mg
Prednisolone 5 mg
Betamezon 0.75 mg
The medicinal product should be used from the neonatal period only if absolutely necessary. During treatment with dexamethasone, careful monitoring of the growth and development of children and adolescents is necessary.
Symptoms. There are very rarely reports of acute overdose or death due to acute overdose. Overdose (usually only after several weeks of using excessive doses) is manifested by symptoms of an increase in the described side effects, in particular: first of all, Itsenko-Cushing's syndrome, acne, ecchymosis, hirsutism, nausea, anorexia, gastrointestinal ulcer, arthralgia, myopathy, myalgia, shortness of breath, dizziness, loss of consciousness, fever, increased blood pressure, hyperlipidemia, osteoporosis, orthostatic hypotension, development of infections, steroid diabetes, "moon-shaped" face, sexual dysfunction.
Treatment: symptomatic and supportive therapy. There is no specific treatment or antidote. Hemodialysis is not effective.
The frequency of adverse reactions depends on the dose and duration of treatment.
Adverse reactions with short-term treatment.
Gastrointestinal disorders: peptic ulcer, acute pancreatitis.
Immune system disorders: temporary suppression of adrenal function.
Metabolic and nutritional disorders: decreased tolerance to carbohydrates, increased appetite, weight gain, hypertriglyceridemia.
Psychiatric disorders Mental disorders.
Immune system disorders: Hypersensitivity reactions.
Adverse reactions with long-term treatment.
Eye disorders: cataracts, glaucoma.
Immune system disorders: prolonged suppression of adrenal function, delayed growth in children, premature closure of the epiphyseal growth zones.
Metabolic and nutritional disorders: obesity.
Cardiac disorders: arterial hypertension, telangiectasia.
Immune system disorders: a decrease in the immune response and an increased susceptibility to infectious diseases.
Skin and subcutaneous tissue disorders: thinning of the skin.
Musculoskeletal and connective tissue disorders: muscular atrophy, osteoporosis, fractures of tubular bones, aseptic necrosis of bones.
Adverse reactions that can occur in individual organs and systems during treatment with dexamethasone.
Eye disorders: increased intraocular pressure, glaucoma, cataract, exophthalmos, papilloedema, thinning of the cornea or sclera, retrolental fibroplasia, exacerbation of ophthalmic viral or fungal diseases.
Respiratory, thoracic and mediastinal disorders: pulmonary edema.
Gastrointestinal disorders: nausea, vomiting, dyspepsia, hiccups, flatulence, esophagitis, esophageal candidiasis, increased or decreased appetite; rarely - peptic ulcers of the stomach and duodenum, ulcerative perforations and bleeding in the digestive tract (bloody vomiting, melena), pancreatitis and perforation of the gallbladder and intestines (especially in patients with chronic inflammation of the intestines), atony of the digestive tract are also possible.
Hepatobiliary disorders: increased levels of liver enzymes, hepatomegaly.
Immune system disorders: suppression of the function and atrophy of the adrenal glands (decreased response to stress), suppression of the hypothalamic-pituitary-adrenal system, Itsenko-Cushing's syndrome, delayed sexual development in children, impaired secretion of sex hormones (menstrual irregularities, amenorrhea, hirsutism, impotence ), hyperglycemia, "steroid" diabetes mellitus, the transition of latent diabetes to a clinically active form, a decrease in carbohydrate tolerance, an increased need for insulin or oral antidiabetic drugs in patients with diabetes mellitus.
Metabolic and nutritional disorders: increased excretion of calcium ions, hypocalcemia, increased body weight, negative nitrogen balance (increased protein breakdown), fluid and sodium ion retention (peripheral edema), hypernatremia, increased production of potassium ions, hypokalemic syndrome: hypokalemia, hypokalemic alkalosis, arrhythmia, myalgia or muscle spasm, tumor lysis syndrome.
Nervous system disorders: after treatment, edema of the optic nerve head and increased intracranial pressure (pseudotumour), exacerbation of epilepsy, dizziness, fainting, convulsions, headache, hyperkinesia, neuritis, neuropathy, paresthesia may occur; in children, the drug can cause paralysis of the cerebral cortex.
Psychiatric disorders changes in personality and behavior, which often manifest themselves in the form of affective disorders (irritability, euphoria, delirium, paranoia, nervousness, anxiety, disorientation, depression, mood lability, suicidal thoughts), sleep disturbances, cognitive dysfunction (including confusion and amnesia), psychotic reactions (including mania, hallucinations, psychosis and exacerbation of schizophrenia).
Cardiac disorders: paroxysmal bradycardia, cardiac arrest, cardiac arrhythmias, angina pectoris, heart enlargement, vascular insufficiency, congestive heart failure, chronic heart failure, fatty embolism, arterial hypertension, hypertrophic cardiomyopathy in premature infants; very rarely - heart rupture in patients who have recently had myocardial infarction; also possible polytopic ventricular premature beats, hypertensive encephalopathy, tachycardia, thromboembolism, thrombophlebitis, vasculitis.
Blood and lymphatic system disorders: cases of thromboembolism, thrombophlebitis, a decrease in the number of monocytes and/or lymphocytes, leukocytosis, eosinophilia (as with the use of other glucocorticoids); rarely - thrombocytopenia and non-thrombocytopenic purpura.
Immune system disorders: hypersensitivity reactions, including rashes, itching, flushing, allergic dermatitis, urticaria, Quincke's edema, bronchospasm, anaphylactic shock, immunosuppression.
Skin and subcutaneous tissue disorders: suppression of regenerative and reparative functions of the skin, delayed wound healing, thinning and sensitive skin, dry skin, skin atrophy, hyper- or hypopigmentation, subcutaneous tissue distribution disorders, ecchymosis, sterile abscess, petechiae, acne, stretch marks, telangiectasia, and vaccinations.
Musculoskeletal and connective tissue disorders: muscle weakness, muscle atrophy, steroid myopathy (muscle weakness causes muscle catabolism), osteoporosis (increased calcium excretion), fractures of the tubular bones or compression fractures of the spine, aseptic osteonecrosis (often aseptic necrosis of bone heads) shoulders), tendon ruptures (especially with the simultaneous use of some quinolones), growth retardation and bone mineralization in children, premature closure of the epiphyseal growth zones.
General disorders and administration site conditions: hypersensitivity reactions, including rash, itching, redness and tingling of the skin, painless destruction of the joint, which symptomatically resembles neurogenic arthropathy (Charcot's joint).
Other: unusual weakness and fatigue, increased risk of occurrence or exacerbation of fungal, viral or bacterial infections, the development of opportunistic infections, inhibition of regenerative and reparative processes, edema, sweating, leukocyturia, withdrawal syndrome. The medicinal product can be physically addictive.
Signs of glucocorticosteroid withdrawal syndrome.
In patients treated with dexamethasone for a long time, withdrawal syndrome and adrenal insufficiency, hypotension, and possible lethal outcome may occur during very rapid dose reduction. In some cases, the symptoms of withdrawal syndrome may be similar to signs of worsening or recurrence of the disease from which the patient was treated.
Shelf life.2 years.
Special precautions for storage
Store in the original package at a temperature not exceeding 15 °С. Do not freeze. Keep out of the reach of children.
Concomitant use of retortin and dexamethasone is contraindicated as it may lead to pulmonary edema. Fatalities have been reported for women in labor due to the development of this condition.
Nature and contents of container.
1 ml in an ampoule; 5 ampoules in a contour honeycomb package; 2 contour honeycomb packages in a pack; 5 or 10 ampoules in a contour honeycomb package; 1 contour honeycomb package in a pack.
Category of release. Prescription only medicine.
Manufacturer. PrJSC "Pharmaceutical firm "Darnitsa".
The manufacturer's location and address of the place of business
13, Boryspilska Street, Kyiv, 02093, Ukraine.
Date of last revision.


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What boosted Goethe's interest in the Prophet Muhammad
The Age of Enlightenment, which gave rise to the French Revolution, undermined the church's authority in Europe. While the church previously controlled all the information on Islam and Prophet Muhammad, this began to be questioned with the Enlightenment. The details on the prophet, in particular, were investigated once again, which manifested itself in the fields of culture, arts and literature. Anti-Islamism under the control of the church lost influence; however, the hatred took a different form this time. For instance, Voltaire, a prominent French Enlightenment writer, pushed all his humanist ideas to the background and targeted Prophet Muhammad. He prepared a disparaging stage play featuring imputations about him, which formed a basis for many radical secularist plays. Despite all these publications that fueled hatred in Europe, there were also those who praised and defended the prophet. German Johann Wolfgang von Goethe, one of the most prominent writers of world literature, is the poster child of this.
Published 11.11.2020 22:14

domain: library


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WRHS GIRLS BASKETBALL: Hornets prep for showdown with SHS
The White River High girls picked up two more South Puget Sound League 2A victories and appear headed toward a first-place showdown with the Sumner Spartans.
There’s still basketball to be played before Tuesday night’s showdown on the Spartans’ court, but each appears poised to enter the contest undefeated in league play. It will be the first of two meetings between clubs that have quickly moved to the top of the SPSL 2A ladder.
Before squaring off against the Spartans, the Hornets will host Fife Friday night.
White River improved to 4-0 in league play with a 65-54, home court victory over Eatonville Friday night.
The Hornets grabbed a 22-15 lead after one quarter of play and kept a healthy advantage to the end.
Six White River players cracked the scoring column and four were in double figures. Rani Wiegand led the way with 21 points, Kennedy Hobert added 14, Sabra Sproul finished with 13 and Brooke Paulson chipped in with 12.
The Hornets had improved to 3-0 in SPSL 2A play Jan. 4 when they blasted the visiting Washington Patriots 68-50.
The outcome was never really in doubt as White River raced to a 23-4 lead after eight minutes and took a 40-14 advantage into the locker room at halftime. The Hornet lead increased to 28 points by the end of the third quarter.
The White River offense was sparked by Wiegand and Hobert, who poured in 21 and 20 points, respectively. Paulson added 10.


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ILP420 Urban Morphology an interdisciplinary approach to studies in urban planning and development
Showing course contents for the educational year 2016 - 2017 .
Course responsible: Elin Børrud
Teachers: Marius Grønning
ECTS credits: 5
Faculty: Faculty of Landscape and Society
Teaching language: EN
Limits of class size:
The course will run depending on interest from potential participants.
Teaching exam periods:
January and spring semester.
Course frequency: The course will not be offered in 2017.
First time: Study year 2015-2016
PhD students at ILP and other SAMVIT departments
Urban Morphology is the study of the physical (or built) fabric of urban form, and the people and processes shaping it. It is a theoretical method to describe and explain the physical planning context as form and thus transformation, in which planners, architects and developers interact.
The course gives both a theoretical and practical insight in how Urban morphology as an interdisciplinary approach can contribute to research in urban planning and development issues. The overall aim is conceptualizing the complexity of urban form and to present guidelines for mapping, describing and explaining urban change and transformation.
Lectures, seminars, excercises, self study.
A reference list will be given at the course start.
Attendence at minimum 70% of the lectures and seminars
Submitting and presenting an academic paper.
Enrolled as a PhD student
Examination details: Continuous exam: Bestått / Ikke bestått


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The MLB season lasts half the year, and it can be hard for the average fan to keep up. That’s where we come in. Every day during the 2017 regular season, Beyond the Box Score will be recapping all the biggest action from the previous day — with a sabermetric slant, of course — and looking ahead to what today will bring.
Yesterday’s biggest play
Kendrys Morales keeps the Blue Jays alive — +.435 WPA
For the second straight day, the Blue Jays came from behind late, and are featured in this part of the recap. Yesterday’s recap involved a Kendrys Morales home run as well, though it was the homer that followed the game-tying home run; this time, it’s Morales who tied the game, and was followed an inning later by Steve Pearce, who hit a walk-off grand slam in the bottom of the 10th.
In a vacuum, there wasn’t a lot wrong with this pitch from Blake Treinen; sinkers low in the zone have a lot going for them, and it looks pretty impressive that Morales was able to get underneath it and send it out to center. But this was the fourth straight sinker Treinen threw, and the first pitch of the plate appearance was a sinker just inches away from this one that Morales did indeed whiff on. The sinker is Treinen’s main pitch — he’s thrown it more than half the time this season — but mixing in a slider or changeup could’ve gone a long way.
The trade deadline is weird for several reasons. Oakland is still barely removed from a couple trades, including the one that sent the better parts of their bullpen, Sean Doolittle and Ryan Madson, to the Nationals. You obviously can’t say with certainty that either of those pitchers would’ve done a better job than Treinen in the 9th (or than Liam Hendricks in the 10th, when three walks and the aforementioned walk-off grand slam made this game seem a lot less close than it was). But there is still something very odd about watching a team make it’s major-league roster worse, and feeling the effects of that change less than a week later.
For the Jays, the weird part is the uncertainty surrounding the rest of this season. A winning streak of five or six games can be enough to convince a team on the bubble (like the Jays) to go for it, or at least not sell off pieces; the Blue Jays, after getting swept by the Indians last week in three games, completed a four-game sweep of the A’s with this win. Any of the heroes of this game could be on the team next week, or they could be sent away for a motley collection of 18- and 21-year-olds. July is weird.
Yesterday’s best game score
Zack Godley — 77
Game Score was developed by Bill James as a quick way to evaluate a starting pitcher’s performance, and recently updated by Tom Tango. The score begins at 40, with points added for outs and strikeouts, and subtracted for walks, hits, runs, and home runs. A score of 70 is very good; a score of 90 is outstanding.
The Diamondbacks rotation has been one of the biggest drivers of their surprising success this season — with 12.3 fWAR, they trail on the Dodgers in MLB — and Godley has in turn been a big part of that. He was in fine form last night, going seven innings and striking out seven Cardinals while walking just two, allowing four hits, and keeping St. Louis off the scoreboard entirely.
As the above gifs demonstrate, Godley’s best weapon on the night was his vicious curveball, which he threw 38 times on the night and with which he garnered ten of his thirteen whiffs. His other most-used pitch was his sinker, and while it didn’t get any whiffs, it frequently went for a first-pitch called strike or a foul, and in conjunction with the curveball, allowed Godley to get ahead in counts while still keeping hitters off-balance and preventing any serious damage on balls in play.
On the season, the Arizona righty’s ERA has fallen to a sterling 3.06, with a 3.03 FIP and 2.84 DRA to match. This is his first season of success at the major-league level, and with 28 innings in the minors to start the year before his 88 innings in the majors, he’s rapidly approaching his past innings totals, so it’s not clear to what extent the DBacks will be able to rely on Godley in October. But with lots of impressive starting pitching depth, his availability in the postseason might actually be less important than the fact that he’s giving them great innings in July.
Yesterday’s biggest home run
José Abreu — 454 feet
I go on a lot in this space about how milestones in the outfield — upper-decks, statues, natural formations, whatever — are good for home runs, since they provide some context for a deep blast, and allow you to appreciate a huge home run in the moment, not just with the help of Statcast data. But there’s something to be said for a nice, simple homer that lands fifteen or twenty rows back. On the one hand, if the bleachers are the only point of reference, really long home runs can be hard to distinguish from the merely long home runs; on the other hand, a baseball landing two-thirds of the way into a section that starts more than 400 feet from home plate is awesome. This is a nice-looking home run, is what I’m trying to say.
Abreu got a first-pitch curveball from Jon Lester and wasn’t fooled, holding back on it long enough to send it into orbit. The Cubs lefty had struck out the North Side-slugger in the first inning with a curveball in nearly the exact same place:
Abreu may have fallen from the lofty heights of his rookie season, but he’s still a very formidable hitter, and 2017 has seem him rebound somewhat. His power numbers are the highest they’ve been since that 2014 season, and his 130 wRC+ is also the best of the last three years. This was one of two home runs he hit last night, bringing his total to 18 on the year. Jon Heyman reported recently that the White Sox weren’t planning on trading Abreu, thanks to the limited market for first basemen at this deadline. But with Abreu under contract for two more years, and a promising crop of youngsters in the newly stocked White Sox farm system, it’s not impossible to imagine that he’ll be a part of their next competitive team.
- Several teams are still undecided (at least publicly) on their direction at the trade deadline, the Orioles chief among them. At Camden Chat, George Battersby breaks down the timeline of comments and reports out of Baltimore, and tries to explain the front office’s probable thinking.
- Ever since the start of the one-game Wild Card playoff, some folks have poo-pooed the meaning of reaching it, given the possibility of an abrupt exit it carries. But Adam Peterson of Purple Row is here to convince you that the Wild Card game matters plenty, especially to a fanbase as starved for success as the Rockies, and that it’s worth trading away some prospects to push for it. (He’s totally right, too!)
Tonight’s best pitching matchup
Alex Wood (3.39 projected ERA) vs. Matt Moore (4.16 projected ERA)
If you focus on the names, this might not look like one of hte lopsided matchups that seem to appear so frequently in this space, and indeed, even the projections think this should be fairly well-matched. But the projections focus a lot on track record, and if we look at the more recent performance of both these pitchers, this has the potential to be a bloodbath. Wood is coming off a rough start (nine runs in 4 2⁄3 innings) against the Angels, but his season is still fairly described as a breakout, what with the 2.17 ERA, 2.44 FIP, and 2.75 DRA. He’s been outstanding, and while he’s well beyond the maximum innings he’d thrown in any season prior to this one, Wood could stop pitching today and still have been a huge and happy surprise for the Dodgers.
You could imagine a similar narrative developing around Matt Moore, had a few things gone differently. But surgeries and general ineffectiveness have not only kept him from making the jump to excellence, but pushed him into a disappointing 2017 with the Giants. His ERA of 5.82 is worse than his FIP of 4.66, but his DRA of 7.51 is downright horrific, suggesting that bad luck probably hasn’t been his problem. There’s still potential here, which is why the projections are optimistic, but Moore isn’t the real attraction of this matchup.


When I heard that J.K. Rowling was partnering with Warner Brothers and writing the script to a new film set within the Wizarding World of Harry Potter, I was not quite sure what to feel. As someone who grew up on the books and is a fan of the films in their own right, I felt a mix of trepidation and excitement at the prospect of an expansion of that universe. When I learned that said film was to be a prequel, I felt a twinge of apprehension. As a Star Wars fan, I had been down this road before, and in my experience it rarely ends well. When I discovered that said prequel was to be based on a textbook mentioned in the book series, I became concerned. But when I heard that said film would be the first in a new five film franchise set within the world of Harry Potter, the alarm bells really started to go off. There seemed to be far too many factors working against this film at the start for me to have any hope of it being enjoyable. I’m happy to say that I was proven wrong, and that FANTASTIC BEASTS AND WHERE TO FIND THEM is, while not a perfect film by any stretch, at the very least a perfectly serviceable good time at the movies. Rowling’s latest edition to the larger story of the Wizarding World of Harry Potter has a lot to say (sometimes too much), but also makes sure to make room for laughter, awe, adventure, and even a few thrills along the way.
For the uninitiated to the world of Harry Potter, the general plot of FANTASTIC BEASTS might be a little hard to follow, so I will attempt to give a brief overview of the general story while avoiding any actual spoilers. The plot of FANTASTIC BEASTS focuses on the story of Newt Scamander (Eddie Redmayne), a wizard who, by the time the story of Harry Potter begins, is quite the famous magical zoologist and the author of a famous textbook which shares its title with our film, sort of like a magical British Steve Irwin. Scamander has come to America on a somewhat secretive personal mission, bringing along with him an enchanted briefcase in which resides a magical zoo containing the various creatures he has encountered and cataloged over the years, many of which have names that should be familiar to readers of the Harry Potter books. After a bit of a mishap, this case is opened and several of Scamander’s creatures manage to escape and begin to cause problems throughout New York City. However, all of this is going on against the backdrop of a larger mystery that is going on in the city, one which threatens to expose the American magical community. Throughout the story Scamander encounters a wide cast of characters, with notable standouts being bumbling No-Maj (American for “muggle”) Jacob Kowalski (Dan Fogler), menacing magical law enforcement officer Graves (Colin Farrell, doing what he does best), and the enigmatic and troubled Credence Barebone (Ezra Miller in a standout performance).
After the barebones of the plot have been set in place over the first 30 or so minutes of the film and the brief case has been opened, the film really manages to take off. The many creatures that Scamander is trying to retrieve are visually stunning and a testament to the hours on end that the art department spent visualizing them. Each has just enough in common with real world animals to make them seem possible, while at the same time maintaining the, and pardon the pun, fantastical element that made the Harry Potter films distinctive. The creatures and Scamander’s interactions with them, are also directly responsible for the bulk of the film’s best comedic moments, as he truly does manage to almost channel the spirit of slightly mad zoologists in the way in which he handles and responds to them. This sense of wonder and levity is somewhat compromised by an abrupt switch to a significantly darker tone and visual palette as the plot unfolds, though once the shock wears off it does manage to quickly find a groove and acquit itself quite nicely within the parameter of the new tone that it has established for itself. It is worth noting that near the very end of the story, the plot does take a bit of a turn for the absurd as it attempts to do the heavy lifting required in order to set up and justify the four additional films that are slated to be part of this new franchise. Throughout the film as a whole the weakest points are consistently those where it is attempting to set up plot points for future films, as in those moments it no longer feels like it is servicing the film that you are currently viewing. These problems, however, do not manage to derail the film as it is able to course correct and stick the landing with a gorgeously rendered and deeply emotional final few sequences that manage to put a neat bow on the package.
There is a lot going on in FANTASTIC BEASTS, sometimes too much. Rowling clearly had a lot that she wanted to say, and as a result the messages tend to become muddled at times. It, for the most part, simply reads as a writer of novels somewhat struggling against the constraints of a film script, making it somewhat unclear as to what the film is about until a decent ways in. While watching the film, there were two primary themes that did stand out though, with the first being the importance of preserving the world we live in and the various wonderful creatures that reside therein, and the second being the importance of being true to who you are and the negative consequences of hiding from or suppressing one’s true self. While Rowling could have arguably done more to foreground these themes, the fact that they are present implies that she still very much has something to say within the confines of this world, and this writer is more than willing to tag along the rest of the way to see what that is.
While it is by no means perfect, I could not help but walk away from FANTASTIC BEASTS AND WHERE TO FIND THEM both satisfied and fairly surprised. If you are a fan of the world in which it is set there is plenty to love and more than enough to make the prospect of four more films at the very least interesting. It may at times come in fits and starts, but during the two hours in which you are in the theater, you might just believe in magic once again, and that is something we are sorely in need of right now.


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WASHINGTON—The Biden administration on Monday delayed proposing detailed rules for new tax incentives for electric vehicles, following strong pushback from European and Asian allies that the subsidy program discriminated against their companies.
The Treasury Department said details on the battery-sourcing requirements that electric vehicles must meet to qualify for up to $7,500 in tax credit will be released in March, instead of by the end of this year as earlier planned.
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domain: politics


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I woke up to a cliff dwelling morning. The sun was my clock. The tea was sage, a sprig gathered the previous day to settle a slight indigestion. Pup ate fish stuff for breakfast and I had a timely-named “Clift” bar. The crows rose on drafts of air and a rufous-sided towhee rustled in the leaves attracting the dog’s attention.
Around the late 1200’s there were over 600 separate cliff dwelling villages nestled across the area now known as Mesa Verde National Park. I have seen many photos of cliff dwellings, but I think I mistook them for being one and the same. Driving along the cliff tops of the Mesa Verde National Park I began to realize that I had been quite mistaken. At times I could see as many as five separate cliff dwelling villages across a canyon, knowing that below my feet were more that I could not see.
I had arrived on a Thursday afternoon with enough time to slowly wander by the cases of artifacts removed from various dwellings over time. The Anasazi as they were once called (now Ancient Puebloans) mysteriously left them homes in the cliffs in mass exodus around 1270 leaving much behind, as though expecting to return one day. The well-concealed and difficult to access villages mostly remained lost until the late 1800's.
The Spruce House Dwelling basked in the sun when I began trudging down the path. I spent some time examining it’s unique t shaped doors and layers of rooms beneath the overhang. The T shaped doors opened mostly into public and often spiritual centers. Rectangular doorways could be sealed with a stone. (Imagine that. Screws were not invented until the 1400’s in Europe. No one had an easy way to close an opening… but a stone door?)
|Notice the bottom door was redesigned into a rectangle.|
Take your time to peruse these photos. These stones waited patiently eons for you to see.
I have been reading books on these ancient people and attended an evening ranger talk floating theories of why they left. Some say war, some say drought and some say that as key contributors left the community, the remaining community fabric disintegrated. I have another theory. Hearing rangers warn older visitors to by-pass climbing down ladders and descending and ascending the hundreds of almost vertical steps, I began to wonder if the Anasazi suffered from a generational shift towards too many elders.
Old in Anasazi years would have meant to be in your mid to late 40’s. A lifetime of lifting stones and climbing steep walls to get to the crops on the top would have caused arthritis or heart conditions. Poor nutrition due to drought may have caused more infant deaths. Just as we now have an aging population, the Anasazi elders may have wished to move to flat land, one level homes much like ranch houses. A shift from high-rise tenements without elevators to the suburbs with drive to the door capacity. My theory… just pondering all those stairs and cliffs.
|Tallest Structure in Mesa Verde|


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During the PKS Summer Camp in Maremma, every day is a new adventure. Participants will have the opportunity to choose from a variety of water sports including kitesurfing, wingfoiling, windsurfing, and sailing. Our certified instructors will guide you through the process, teaching not only the techniques, but also the beauty and joy of these sports. Whether you’re a beginner or an experienced enthusiast, our program is designed to accommodate all skill levels, ensuring everyone has a great experience.
The fun doesn’t stop at the water’s edge. Our camp offers a full itinerary of daily activities to ensure there is never a dull moment. You may find yourself exploring the charming local village, hiking in the beautiful Tuscan landscapes, or simply enjoying the company of new friends in the Tuscan sun.
This all-inclusive camp isn’t just about sports and activities, it’s about creating memories that will last a lifetime!


Your child can turn into a firefighting superhero in their dreams under this firefighter duvet set. Great for boys and girls who aspire to being a fireman or firewoman, this super realistic kids single or double duvet cover will inspire them and boost their imaginations. When they lie down the helmet sits on their head perfectly. Available as a single or double and made from organic cotton this firefighter bedding set will help a good nights sleep.
Designed in Holland. Made in Portugal
Made from: 100% soft cotton, thread count 160
Suitable for age: 3 years to adult
Colours: Multi coloured
Single duvet size: 200cm x 135cm
Double duvet size: 200cm x 200cm
Single bedding set includes 1 pillowcase, double bedding set includes 2 pillowcases
Additional dimensions: Pillowcase 75cm x 50cm
Care Instructions: Machine Washable at 40 degrees. Suitable for tumble dryer.
Please note that due to huge demand we are trying to fulfill all our bedding orders but we will email you once an order is placed to let you know the timings we are working to at time of order for the product you have ordered. This is of special note for doubles as these are made to our specification and take at least 2 weeks. We do apologise for this and are doing everything we can to fulfill as many orders as possible.