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Nibbles wants some milk, so Jerry tries to steal some from Tom. The Tom and Jerry Episodes is about 162 from 1940 to 2004, in 2006 the Tom & Jerry Tales released with 26 Episodes. Tom competes with an alley cat (Meathead) to see who gets Jerry first. The Invisible Mouse. After a piano flattens Tom while he attempts to catch Jerry, Tom is refused entry to cat heaven due to his record of trying to harm Jerry. Tom & Jerry Watch Free Online Tom & Jerry Cartoons and Enjoy in Your Best Tom and Jerry Full Cartoon, Here you can find other Classical Tom & Jerry Cartoons. Final short not to feature the Leo The Lion as intro. First appearance of Tom's bald owner. Aaron's New Tom & Jerry Information Site
Tom and Butch compete against each other in a game of tennis. The Cat Concerto. Tom calls a mouse exterminator (Butch) to get rid of Jerry. Jerry and Nibbles flood the kitchen and freeze it, turning it into a skating rink as well as freezing Tom. Jerry and Tuffy dine on Thanksgiving treats until Tom tries to stop them. Re-released with Perspecta Stereo in 1957. They work together to prove Tom's worth as a mouse-catcher to Mammy. The filmography of the cartoon series Tom and Jerry, 1961–1962: Gene Deitch/Rembrandt Films cartoons, 1963–1967: Chuck Jones/Sib Tower 12 cartoons, 2001: Hanna-Barbera Productions/Turner Entertainment cartoon, Leonard Maltin's book of Mice and Magic: History of American Animated Cartoons, Tom and Jerry: The Chuck Jones Collection, Tom and Jerry: Robin Hood and His Merry Mouse, Tom and Jerry: Willy Wonka and the Chocolate Factory, https://twitter.com/WarnerMedia/status/1266102388424716290, Tom and Jerry episode guide: The Hanna–Barbera era (1940–1958), Tom and Jerry episode guide: The Gene Deitch era (1960–1962), Tom and Jerry episode guide: The Chuck Jones era (1963–1967), Tom and Jerry episode guide: Warner Bros. Tom and Jerry Classic Episode 3 - The Night Before Christmas. Tom and Jerry return with vengeance in this new show. Last cartoon to get nominated for an. The Million Dollar Cat. Tom offers Jerry as a gift to a wealthy and attractive female cat (Toodles). Springtime For Thomas. The ensuing game of cat-and-mouse, however, could very well bring down the ceremony all on its own. All cartoons were released to theaters by Metro-Goldwyn-Mayer. It is the series premiere of the Tom & Jerry Kids. Tom must get rid of Jerry and Nibbles without waking up the king. Big Cartoon Database
Tom and Jerry babysit their nephews, which prove too much for the both of them. First appearance of Jumbo and his mother. A little girl dresses up Tom like a baby, prompting Jerry and Tom's feline friends to make fun of him. Plot. DC Kids Tom and Jerry the Extra-Terrestrial (1982) with cameo on television E.T. Find TV episodes, reviews, ratings, lists, and links to watch Tom and Jerry online on SideReel - Tom and Jerry is an Academy Award-winning animated cartoon series of Metro-Goldwyn-Mayer theatrical shorts created, written and directed by animators William Hanna and Joseph Barbera (later of… Jerry fights back to make sure that Spike keeps his cool./Tom is under strict orders to not wake the Witch sisters, but Jerry is set on getting Tom in trouble. This annoys Spike, causing him to threaten Tom to keep quiet, while Jerry tries to frame him. ***
Tom and Jerry is an American animated franchise and series of comedy short films created in 1940 by William Hanna and Joseph Barbera.Best known for its 161 theatrical short films by Metro-Goldwyn-Mayer, the series centers on the rivalry between the titular characters of a cat named Tom and a mouse named Jerry.Many shorts also feature several recurring characters. The following 48 cartoons were produced by Hanna-Barbera Productions in association with MGM Television in 1975 for ABC based on the theatrical Tom and Jerry short series. Tom and Jerry Online is an Unofficial Fan site dedicated to the antics of the famous Cat and Mouse duo, Tom and Jerry! Tuffy gets frustrated when Jerry repeatedly asks him to deliver his love letters despite him encountering troubles with Tom along the way. Tom and Jerry might be a classic cartoon duo, but they weren't always so close. My Series. Tom & Jerry All Episodes(389) Movies Preview remove-circle Share or Embed This Item. Rarely seen on Cartoon Network and Boomerang due to intense content. The Cat Concerto. Produced in CinemaScope. Re-released with Perspecta Stereo in 1958. Each episode of the series follows either one of these scenarios: EMBED. The Tom and Jerry Show (2014) Episodes, The Tom and Jerry Show (2014) season 1, The Tom and Jerry Show (2014) season 2, and 2 more The Tom and Jerry Show (2014) season 3 Directors (if other than Jones) or co-directors for each short are listed. Tom and Butch compete against each other to catch Jerry on Mammy Two Shoes' orders, but she ends up kicking out all three animals. Here you fint both the broadcast episodes as the next episodes. Tom and jerry cartoon full episodes classic collection tom and jerry old episodes full 1940. Butch disguises himself as a baby to steal food from Tom and Jerry's household, aggravating both of them. The following 34 cartoons were produced by Chuck Jones in Hollywood, California, and released to theaters by Metro-Goldwyn-Mayer. Jerry befriends a baby elephant named Jumbo and disguises him as a large mouse to mess with Tom. 62a: 10a "Bride of McWolfenstein" Jim Ryan: November 13, 1993 () Droopy and Dripple's car breaks down in front of a creepy castle. local library and check it out. Trending pages. Produced in CinemaScope and Perspecta Stereo. flag. Fourth compilation film; contains footage from. When Tom eats his owner's chicken and frames Spike, Jerry takes a picture to expose him, spreading copies around the house, trying to get him kicked out. Here you fint both the broadcast episodes as the next episodes. 1a8c34a149 This is a complete list of the 164 shorts in the Tom and Jerry series produced and released between 1940 and 2014. The second of the thirteen cartoons that Tom is victorious over Jerry. Jerry frees Spike the bulldog from the dog-catcher's truck. First cartoon where Tom and Jerry both lose in the end. EMBED (for wordpress.com hosted blogs and archive.org item tags) Want more? First time Tom and Jerry are referred to by those names. Animation and Renegade Animation.Based on the Tom and Jerry characters and theatrical cartoon series created by William Hanna and Joseph Barbera in 1940.The series first premiered on the Canadian channel Teletoon on March 1, 2020 and began airing on Cartoon Network in the United States on April 8, 2020. Edy Play Toys - Tom and Jerry Always Are Amazing. Another series, Tom & Jerry Kids, ran on the Fox network from 1990–93. Last cartoon where Tom loses with another cat.  Most of these cartoons were produced in the standard Academy ratio (1.37:1). Final appearance of Tom's bald owner, as removed from further entrees due to his appearances were subjected to. 5:32. Spike threatens Tom to keep Tyke clean while he's gone. Photos from the individual Tom and Jerry episodes are listed along with the Tom and Jerry episode names when available, as are the dates of the original airing of the episode. Jerry hides with Spike and Tyke so Tom will get in trouble if he tries to catch him. Directors: Joseph Barbera, William Hanna. In this episode, a dog goes for a picnic with his baby pup. Fed up with Tom's laziness, Mammy buys a new mouse-catching robot cat. Won an Academy Awards for Best Cartoon - (Won) Nominated for an Academy Awards for Best Cartoon - (Nominated) Reissued - Made in Cinemascope - Spike and Tyke Spin-Off Cartoon - 1 List of Cartoons 1.1 1940-1958: Hanna-Barbera/MGM Cartoons 1.1.1 … tom and jerry Bangla 2020 tom and jerry Bangla free download tom and jerry Bangla Natok Download Tom and jerry first episode were released on February 10, 1940, and this episode name is Tom And Jerry Cartoon Puss Gets The Boot. ***
Jerry and Quacker become invisible using vanishing cream and play pranks on Tom. Rarely seen on Cartoon Network and Boomerang due to resulted. share. Tom & Jerry is a 2021 live-action/animated comedy film based on the famous animated cat-and-mouse team, and directed by Tim Story.It is the duo's second theatrical film, after the infamous Tom and Jerry: The Movie from 1993.. Season 1 consists of twenty-six 23-minute episodes and fifty-two total shorts. This is a list of Tom and Jerry cartoons. Synopsis: Tom and Jerry is an American comedy slapstick cartoon series created in 1940 by William Hanna and Joseph Barbera. Jerry attracts the attention of another cat (Butch) who also becomes interested in her, resulting in a fight between Tom and the other cat for her affection. After Mammy Two Shoes goes out with her friends, Tom invites his feline friends over for a party, which desturbs a sleeping Jerry. With Henry Corden, Kathy Gori, Don Messick, Alan Oppenheimer. When Tom uses the magic spell wand and makes all of the furniture come alive, he must get the help of Newt to make everything go back as it was. EMBED (for wordpress.com hosted blogs and archive.org item tags) Want more? This reboot of the Tom and Jerry franchise follows the antics of Tom in his pursuit to catch Jerry. List of the best Tom and Jerry episodes, as determined by voters like you. Jerry's tough cousin Muscles protects Jerry from Tom. When Tom steals a chicken drumstick and frames Jerry, Jerry gets even by stealing Spike's bone and frames Tom. Votes: 933 Finally, 19 cartoons were produced in widescreen CinemaScope format only. Number of episodes: 114. First appearance of. Sixth and final compilation film; Contains footage from, Directed by Ben Washam. Much like the Roadrunner cartoons, Tom and Jerry episodes are often just a game of cat mouse (this time literally.) EMBED. Only (albeit brief) time that the face of. Rarely airs on American television for some inappropriate references. 3:00. Tom's usual antics of chasing Jerry wake Tyke up, and the puppy gets the hiccups. Tom and Jerry's Giant Adventure. Series Top 100 News Premium Forum. When Tom falls in love, Jerry's Devil recalls the times when Tom fell in love and caused problems for Jerry. In this Thanksgiving short, Jerry and Nibbles dine on Thanksgiving treats until Tom tries to stop them. Episode Ep. Many thanks to all the contributors! The Milky Waif. 2:57. No_Favorite. Tom and Jerry is an American cartoon that was created by William Hanna and Joseph Barbera for MGM. Tom and Jerry fights over who is going to sleep in the hammock. Series Top 100 News Premium Forum. Tom intends to give an escaped seal pup back to the circus, but Jerry wants to help the pup escape. Produced in CinemaScope and Perspecta Stereo. Sufferin’ Cats! To save himself from cat hell, Tom must have Jerry sign a certificate of forgiveness within one hour. 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tom and jerry episodes 2021


Last week marked the first night of the Thursdays at The Office event and it started out with a bang! Thursday at The Office is a weekly event held in the Music Industry Management office that is open to all Ferris and Gallup students. This event gives students the opportunity to share their skills and talents by performing on the stage in the MIM office. Students who perform get to share their music with other local students who come to watch and enjoy a live performance in a small, relaxed, and intimate setting. The goal of this event is to help local artists develop their talents and provide a safe setting for students to come and relax and to bring students together through music.
Brenden Long, Ashlee Jones, and Nick Graham have been working on getting Thursdays at The Office together since the beginning of the semester and they are all very pleased with the way the first night turned out. Last Thursday was the first night of the event and there was a great turnout for performers and people in the audience. There were five different performances from students and all of the performers were professional and prepared appropriate sets for the scene. The artists performed a wide range of genres and that made for an even more interesting show. The audience was also very engaged and respectful with the acts and even sang along with songs that they knew.
The feedback from Brenden and Ashlee about the turn out from the first week of Thursdays at The Office was great. They both were blown away with how smoothly it went and how great of a turnout there was in attendance and with how positively the audience reacted. There were not any problems with the first round of the event and both Brenden and Ashlee are expecting the show to continue to grow in the weeks to come.
One of the students that performed explained about how he really enjoyed the event and how he thought it was a really interesting experience and how it was awesome to see everyone gathered together to relax and enjoy music with other fellow students.


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Preparing Black and Latina/o Youth for Higher Education—A Culturally Relevant Approach
Michelle G. Knight-Manuel Joanne E. Marciano
Teachers College Press
This book will support teachers, counselors, and administrators in creating a culturally relevant, school-wide, college-going culture to improve educational experiences and outcomes for Black and Latina/o youth. The authors present the perspectives and experiences of 25 students, focusing on the complexities of their daily lives and illuminating some of the significant influences that have supported or hindered their college readiness and access. They situate issues of college access in a national context, provide insight into who and what influences youth’s college-going processes, and engage readers in critical analysis to create culturally relevant policies and practices within their own school contexts.
- Important research findings of a four-year study in a public high school with critical reflection questions.
- Links between culturally relevant pedagogy and college readiness and access.
- “Teacher Responses” that connect the contents of each chapter to the author’s experience working with youth.
- “Reading in Action” sections for professional development with individuals, small groups of educators, and whole school communities
Michelle G. Knight is an associate professor at Teachers College, Columbia University, and a former middle-school teacher and high school college advisor. Joanne E. Marciano is a doctoral candidate and research associate at Teachers College, Columbia University, and a high school English teacher.

domain: literature


Guwahati: Over 1 lakh government jobs are vacant in the state since 2016, Minister Ranjit Kumar Dass said on Tuesday, in response to an unstarred question raised by Debabrata Saikia, Leader of the Opposition, in the ongoing Budget Session.
A total of 1,07,149 posts of all grades in over 50 state government departments are vacant since 2016.
The list, which EastMojo has accessed, says that the Education Department has the highest vacancies with 50,465 vacant posts in all grades lying since 2016.
The Home and Political Department has 20,248 vacant posts since 2016, followed by the Health and Family Welfare Department with 9,353 vacancies.
The Environment and Forest Department have 2918 vacant posts, followed by the Irrigation Department with 2253 vacant posts. The Animal Husbandry and Veterinary Department (AH&V) and Panchayat and Rural Development Department (P&RD) have 2,152 and 2,137 unfilled posts, respectively.
The Public Works Department has 1308 vacant posts in grade 3 and grade 4 positions. The Revenue and Disaster Management Department has 1139 vacancies across all grades.
A total of 1,005 posts in grade 2 and grade 4 positions are vacant in the Public Health Engineering Department. The Guwahati Development Department has over 1092 vacancies in grade 3 and grade 4 positions.
A total of 678 posts in all grades are lying vacant in the Judiciary Department since 2016. Social Welfare Department has 666 vacancies in grade 3 and grade 4.
In the Secretariat Administration, over 719 total posts in grade 3 and grade 4 are lying vacant. In the Sports and Youth Welfare Department, around 712 posts are unfiled in all grades.
In many departments, the numbers of vacant posts are more than 100. Only in 16 departments, the vacancies are below 100, including 2 vacant posts each in Chief Minister’s secretariat, Public Enterprise Department and Pension and Public Grievance Department.
However, Education Minister, Ranoj Pegu on Tuesday replying to a question by Palasbari MLA Hemanga Thakuria, said, “We have taken steps to fill all the vacant posts. Many might think that the Education department alone has more than 50 thousand vacant posts or over one lakh vacant posts in Assam. But in reality, we don’t have those much vacant posts.”
“The government has to create new posts to achieve the one lakh jobs promise including in the Education department. The lying posts in primary education will be filled and will be incorporated in the one lakh job promise,” Pegu added.
On May 11, a high-level committee headed by Finance Minister Ajanta Neog was formed to assess the feasibility and appoint one lakh youths in government jobs.
Addressing a press meet in June, Neog had said, “We have asked departments to send us the vacancy list on a need-basis. We’ll start the appointment process after we get the vacancy list. The process will be transparent and without loopholes.”
The Himanta Biswa Sarma-led BJP government in Assam came into power with a poll promise to provide Assam government jobs to one lakh unemployed youths in the state.
- Army capable of giving befitting reply to any power with evil intentions: Rajnath
- Arunachal: 24 TB patients adopted by three Tawang legislators
- Manipur: Flash floods ruin paddy, fishery ponds in Ukhrul
- Shillong Teer Result today: Check winners of Shillong Teer for September 24
- Khanapara Teer Result today: Winners of Khanapara Teer for September 24
- Voter ID Card: Relationship column rule changed for Assam in conformity with other states


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Welcome to the West Indian Foundation, Inc.
The West Indian Foundation, Inc. was founded by the West Indian Social Club of Hartford, Inc. to serve as the central focus of West Indian cultural, social and educational activities in the Metro Hartford community. West Indians include peoples native to the Independent Nations of the Caribbean islands of the Republic of Trinidad and Tobago, Barbados, St. Christopher, St. Vincent, the Republic of Guyana, The Bahamas, Barbuda, Dominica, Antigua, Belize, Suriname, St. Lucia, Grenada, St. Kitts and Nevis as well as Jamaica.
West Indian Population in the Hartford Area
The West Indian population presently is estimated at over 70,000 in the Metro Hartford area, The Foundation is dedicated to preserving the identity, history, the unique cultural heritage and to educate the community at large in these traditions.
To that aim, the Foundation has produced a wide variety of programs, activities and services.
Scholarship Golf Tournament - Friday, June 23, 2017 @ 12 pm

domain: sociology


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Are you looking for puppies for sale? The current pet market has many options for people who could like to have dogs. Choosing the right short-haired German pointer puppies is not easy as you need to have details about this breed. Use the internet to acquire all the information to help in picking this breed. Breeders are also useful in this case as they will help you identify these types of dogs from the various options in the pet market. Make sure that you choose a furry fellow that fits your compliment and lifestyle. If you are acquiring short-haired German pointer puppies for sale, make sure you buy what is needed in the market.
Be cautious about the available puppy mills especially if you consider using them. Some pet stores are out there to sell dogs that they rescued. They have a list of clients that trust their services and pets. However, there are limitations as you can only choose the available puppies. Note that these animals are weaned off from their mothers very early. They lack developed a personality as they did not interact with their mothers and other litters. Also, some of these pets were born under unfavorable conditions.
However, it is possible to get an adorable and well-mannered puppy from a puppy mill and pet stores. Remember that some dog owners give out their puppies to these centers for mills and shelters for various reasons. For instance, the previous owner could be moving to a new town and there are restrictions against owning pets. Some donate puppies when they feel like the animal is taking a lot of their resources and time. It is worth noting that some short-haired German pointer puppies for sale at shelters or mills are victims of cruelty or neglect. Such puppies are likely to get back to life with some proper diet, medical care, personal attention, training, and exercise. Be ready to commit your resources to rehabilitate and nurse a puppy until they fully recover.
Get your short-haired German pointer puppies for sale from breeders. Breeders spend a lot of time to understand a litter and its personality. These professionals select parents to make sure that the puppy gets the desirable traits. The breeders are ready to respond to all your questions about the dog. Note that the breeders keep records of all puppies in their shelter. Pets at these centers are given out free and you can sell them for returns.
Buying dogs from a shelter allows you to interact with them once they are born. Breeders organize shelter visits for the litters to meet their potential owners. By the time a puppy is two months, it has spent time with its parents and has developed its personality. Make a point of building rapport with available breeders for them to allow you to get the best short-haired German pointer puppies.
Other things to consider before getting a puppy to include deciding on the space needed for the pets to stay before you get their buyers. Are you conducting this business from home or you will need to build up a facility? The number of dogs you handle will determine the space required.

domain: pet


Research Laboratory for Sustainable Systems (RLSS) is an NSF-sponsored research lab.
to the increasing energy consumption by computer systems and
thermal threat to computer systems, environmentally sustainable
computing has received a significant attention in industry and
research. The goal of sustainable computing is to efficiently and
effectively manage system resource to render the
computing sustaiable with minimal impact on the environment.
The underlying systems are pretty diverse, ranging from embedded
systems to high-performance chip-multiprocessors to server clusters in
data centers. Many applications on these systems demand timing
their applications. One of our research goals is to study these
timing-sensitive applicaitons on the diverse sustainable computing platforms.
On the other hand, many systems are highly
vulnerable to faults or attacks, which can compromise the system
performance, corrupt important data, or expose private information. The
other major research goal to design
approaches to render systems more sustainable,
secure and trustworthy.


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Obtain the data you need to make the most informed decisions by accessing our extensive portfolio of information, analytics, and expertise. Sign in to the product or service center of your choice.
Threats and Opportunities in an Environment of Increasing Uncertainty
As the energy markets evolve, investment implications for the petrochemical industry have become more complex. With much riding on your decisions, you need insights that are actionable, comprehensive and trusted.
This IHS Markit Industry Briefing will provide you with our latest analysis of the financial and chemical markets, to help you navigate through the threats an opportunities of an industry, increasingly fraught with uncertainty. Register now to confirm your seat.
IHS Markit experts will be presenting on the following topics:

domain: finance


We would like to extend to all those who purchase an Espresso Forge direct from us the unconditional satisfaction guarantee. If for any reason you are unsatisfied with the Forge, we will do everything we can to make it right. We are a small family company and pride ourselves on quality and getting things right.
Returns are accepted within 30 days of shipment as long as there is no major visible wear. If product has visible wear, we can still accept returns at any time, and condition will depend on the amount we are able to refund. Shipping back to us will be handled by the customer, unless problems are due to a factory defect in assembly or non-consumable materials. A restocking fee of 10% will be charged for refunds if product is opened and then returned.
All Forges come with a Limited Lifetime Guarantee*. Included are the following non-consumable stainless machined parts:
- Top Plate
- Bottom Ring
Not included are replaceable parts under normal wear and tear, including but not limited to:
- Shower Screen
- Pressure Gauges
We guarantee the above non-consumable parts to be in good working order for life, fully transferable to any owner of the Forge.
- Normal wear, tear and aging
- Accidental drop
- Cosmetic imperfections
- Damage cause by tampering with or by other than normal use
- Damage or defects caused by mistreatment or modification
- Loss or theft
The above limitations shall be determined solely by an Espresso Forge representative on a case by case basis.
Espresso Forge is not responsible for injury or damage as a result of misuse or abuse of our product. See our terms and conditions for full details.


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...Neurology - Florida - Near Pensacola
~ Employed by multi specialty clinic
~46 doctors in the group - Large referral base
~ Mainly outpatient work - Inpatient work is contingent upon cases presented
~ Call 1 in 4
~ Join 3 other Neurologists on staff
...~5 doctor pulmonary and critical care group
~ Group is part of a 23 doctor multi-specialty group
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Silicon Valley Eyecare Optometry and Contact Lenses
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...0. Dr. Emmett joined the Shea Clinic in 1976 and has had a long and successful career in otology during a formative period in the specialty. The Shea Clinic was founded in 1967 by John J. Shea, Jr., M.D. (1924-2015) but its origins go back to 1926, with the construction...
Regional Practice Administrator - Physician PracticeAs Mount Sinai continues to grow. so does our legacy of caring.Mount Sinai Medical Center is proud to be South Florida's hospital of choice for great medicine. With more than 4000 employees. 500 volunteers. 670 beds. 2...
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* Benefits vary by division, clinical specialty and employment statusPandoLogic. Category:Healthcare, Keywords:Pediatric Emergency Medicine Physician, Location:Blauvelt, NY-10913
...more than 3.5 million people. Each year, more than 120,000 patients receive care at Westchester Medical Center in every clinical specialty through our main hospital, our Maria Fareri Children ' s Hospital - the only all-specialty children ' s hospital in the region - and...
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...Specialty : RN-Psychiatry Travel
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Opportunity for Board Certified Mohs Surgeon or Dermatologist PT/FT or Dermatopathologist for dermatology office. Located in sunny, affluent Naples, Florida. Minutes from the beautiful sunset beaches on the Florida Gulf Coast. Great lifestyle! Flexible schedule. Compassionate...
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...HealthSource Chiropractic of Vicksburg is looking for high energy, Doctor of Chiropractic, to fill a position with our company.
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domain: medical


text:
To the editor of the Bluffton Today who commented on the Crescent moon in the South Carolina flag. The Crescent in the South Carolina flag was worn by the rebel soldiers during the revolutionary war. It is not a moon but was worn just below their necks. A pity more research cannot be done.
Back in the late 80s or early 90s there was a bank robber who was called the gentleman bandit. Well when the FBI caught him, it was discovered that he lived in Rose Hill Plantation with his wife(who I think was a reporter for the Island Packet). I am trying to find information about this man(if he is still in jail etc) but have forgotten his and his wife's name. I also seem to remember she wrote a book about this era of her life. If someone remembers more than I do please post for me. Thank you-as I said this is just idle curiousity and nothing else.

domain: history


Formula Systems (TASE: FORT, Nasdaq: FORTY) yesterday announced net profits of $3 million in the fourth quarter of 2003 against net losses of $8.1 million in the parallel. Compared to the third quarter, Formula Systems' net increased 363 percent.
Controlling shareholder Dan Goldstein took the opportunity yesterday to criticize his detractors over the Formula Vision deal. Apparently Goldstein has taken over two months of knocks over Formula's buying 60 percent of Formula Vision Technologies in exchange for waiving a $35 million debt that FVT owed to Formula. "The test of results has proved that I was right," said Goldstein. "I hope that all those who criticized the Formula Vision deal will now eat their hat!"
Actually investors quite took to the deal, sending Formula stock up 42 percent since the acquisition was announced in December, and Formula Vision up 55 percent. "In contrast to the sharp criticism I have had to suffer from the press," Goldstein continued, "I haven't received even one phone call from Formula investors. They understood that this didn't hurt the share. Some of them don't understand that on occasion in the world of business, a deal can be worthwhile for both sides. For some reason, they assume that if one side is profiting, then the other must be losing.
"In the past decade I have done nothing against the interests of the shareholders. I have not conducted any interested party deal, and I have not given myself any options or bonuses like other managers."
The software group, controlled by brothers Dan and Gad Goldstein, reported yesterday that its fourth-quarter revenues reached $96.8 million, up 27 percent, while sales for the year 2003, topped $367 million, an increase of 29 percent. After seeing an operating loss of $6.7 million in 2002, the group proudly posted operating profits of $11.8 million in 2003.
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Medical Super Clinic takes pride in being one of the nation’s top 22 clinics renowned for providing exceptional, multidisciplinary care and services for patients diagnosed with endometriosis and pelvic pain.
Endometriosis is a condition that affects at least one in nine Australian women. Its impact on the daily lives of those affected can be extensive and debilitating. It takes an average of seven years for those with symptoms to receive a diagnosis, which can have a profound negative impact on their health and wellbeing.
At our general practice, we aim to promote early access to multidisciplinary intervention, care, and treatment to reduce diagnostic delays, thereby contributing to better patient outcomes. Our commitment goes beyond direct patient care. We aim to expand public knowledge of endometriosis and pelvic pain, enhance professional expertise in this area, and streamline access to relevant information and care pathways.


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As I was walking in the mall, I was thinking about my old blog that hasn’t been updated since two years ago. The idea suddenly came to me after the realization that I needed a platform to express myself in a different environment that I’m in right now. Oh, just to let you know I’m on vacation for 3 weeks out of the country and I just thought maybe this is a good start.
For those who came here and read this the first time, I’m sorry if this might be offending in some ways. I might be ridiculed by my grammar lines and stuff. I’m not a journalist, even a writer of some sort but please understand, these are from my brain and I could only figure out things I want to say from my mind and heart.
Yes, this would be like a diary of myself. I’m not going to dilly dally stuff in here. I may be arouse minds that I like to do with myself and get distracted on them, thus I’m writing here to share you a point. That’s my babbling by the way *laugh*.
On a serious note, let’s enjoy ourselves together.
Hang in there!

domain: artistic


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Author – Rebekah Turner
Age – 14+
Josie lives with her uncle Bobby, helping him run his little store in the year 2050. Many people have ‘talents’. Josie has several talents including telekinesis and telepathy but is also a threader – someone who can ‘thread’ (join) with others and either help them strengthen their talents or control them against their will. She’s been told all her life to hide her talents – especially from any authorities as the government insists everyone register them.
When she is nearly caught using her talent illegally (for the 3rd time) her life suddenly changes and she finally faces the people who can tell her about her dead parents.
The Helios Academy are pleased to have her attend their prestigious school but she is no puppet and is wary of everyone. She wants to know what happened to make her parents leave the academy before she was born. On her way to discovering the truth she finds true friends, love and another threader she must defeat.
With a love story, an unlikely friendship, her parent’s hidden past and an experiment that went terribly wrong, all ‘threaded’ through this narrative, this was a riveting read. Would love a sequel!
(School, Love, Science, Secrets, Friendship, Courage, Betrayal, Family)


There is something inherently fascinating about tiny mechanical devices, especially when you’re used to seeing much larger versions. This is the case with [Penguin DIY]’s tiny centrifugal water pump built from 5 ml syringes.
The pump is powered by a small 8 mm diameter brushed DC motor, likely the same type that is used for small toy-grade quadcopters. The tiny impeller is a section of the syringe’s original plunger, with its cross-shaped body acting as the impeller blades. [Penguin DIY] first experimented with the original plunger seal to protect the motor from water, but it quickly melted from friction with the spinning shaft. Silicone sealant was used instead, and the motor shaft was covered with a layer of oil to prevent the sealant from sticking to it. Then the blob of sealant was flattened with a translucent plastic disc to allow clearance for the impeller.
A hole was drilled in the side of the syringe where the impeller sits, and a nozzle cut from the tip of another syringe was glued in place as the outlet. It’s notoriously difficult to get anything to stick to polypropylene syringes, but [Penguin DIY] says in the comments he was able to find an “organic superglue” that worked. With the motor and impeller inserted, the remaining space was also sealed with silicone.
This tiny pump packs a surprising amount of power, and was able to empty a 1.5 l bottle in about one minute with enough pressure to send the jet of water flying. There are still some issues that need to be addressed, though. With the motor completely sealed, it could burn itself quite quickly. A commenter also mentioned that it might suck water into the motor past the shaft after a hot run, as the air inside the motor cools and contracts. Even so, this little pump might be practical for applications that only require short runs, like watering potted plants. If you need more power you could always 3D print a larger pump.
Continue reading “Turning A Pair Of Syringes Into A Tiny Water Pump”
[Renzo Mischianti]’s friend has to keep a water tank topped up. Problem is, the tank itself is 1.5 km away, so its water level isn’t typically known. There’s no electricity available there either — whichever monitoring solution is to be used, it has to be low-power and self-sufficient. To help with that, [Renzo] is working on a self-contained automation project, with a solar-powered sensor that communicates over LoRa, and a controller that receives the water level readings and powers the water pump when needed.
[Renzo] makes sure to prototype every part using shields and modules before committing to a design, and has already wrote and tested code for both the sensor and the controller, as well as created the PCBs. He’s also making sure to document everything as he goes – in fact, there’s whole seven blog posts on this project, covering the already completed software, PCB and 3D design stages of this project.
These worklogs have plenty of explanations and pictures, and [Renzo] shows a variety of different manufacturing techniques and tricks for beginners along the way. The last blog post on 3D designing and printing the sensor enclosure was recently released, and that likely means we’ll soon see a post about this system being installed and tested!
[Renzo] has been in the “intricately documented worklogs” business for a while. We’ve covered his 3D printed PCB mill and DIY soldermask process before, and recently he was seen adding a web interface to a 3D printer missing one. As for LoRa, there’s plenty of sensors you can build – be it mailbox sensors, burglar alarms, or handheld messengers; and now you have one more project to draw inspiration and knowledge from. [Renzo] has previously done a LoRa tutorial to get you started, and we’ve made one about LoRaWAN!
Continue reading “LoRa Helps With Remote Water Tank Level Sensing”
Lobe pumps are perhaps most popularly known for their use in Rootes-type superchargers, but they can pump water, too. [Let’s Print] demonstrates this ably with a 3D-printed design that can pump with the best of them.
The design uses two figure-eight shaped counter-rotating rotors, or lobes. As the rotors turn, they trap fluid between the rotor and the housing, forcing it towards the outlet. It’s a positive-displacement design, meaning it traps a fixed volume of fluid in each rotation, moving it from inlet to outlet.
The design requires proper timing of the two rotating lobes in order to ensure they maintain the closed volume and don’t impact each other. This is achieved with a pair of timing gears on the back of the pump. The housing, lobes, and gears are all 3D-printed, making this a build that anyone can replicate at home with their own printer.
ABS was used for the rotors for its better handling of friction without melting as easily. However, resin-printed lobes were also employed for their higher tolerances, too, with both designs working acceptably in practice.
The pump still needs more improvement; the hope is to reduce the leaks out of the rear of the pump. [Let’s Print] also intends to add a motor to the pump itself rather than using a power drill to run the device. It’s great to see these 3D-printed pump builds continuing in earnest. Video after the break.
Continue reading “3D-Printed Lobe Pump Shifts Water Well”
How much water have you had to drink today? We would venture to guess that the answer is somewhere between ‘absolutely none’ and ‘not not nearly enough’. You can go ahead and blame poor work/life balance — that’s our plan, anyway — and just try to do better. All this working from home means the bathroom situation is now ideal, so why not drink as much water as you can?
But how? Well, you’re human, so you’ll need to make it as easy as possible to drink the water throughout the day. You could fill up one big jug and hoist it to your mouth all day long (or use a straw), but facing that amount of water all at once can be intimidating. The problem with using a regular-sized vessel is that you have to get up to refill it several times per day. When hyper-focus is winning the work/life tug-of-war, you can’t always just stop and go to the kitchen. What you need is an automatic water dispenser, and you need it right there on the desk.
[Javier Rengel]’s water pomodoro makes it as easy as setting your cup down in front of this machine and leaving it there between sips. As long as the IR sensor detects your cup, it will dispense water every hour. This means that if you don’t drink enough water throughout the day, you’re going to have it all over the desk at some point. [Javier] simply connected an Arduino UNO to a water pump and IR sensor pair and repurposed the milk dispenser from a coffee machine. Check it out in action after the break.
Of course, if you aren’t intimidated by the big jug approach, you could keep tabs on your intake with the right kind of straw.
Continue reading “Drink Water On Schedule Or Else Flood Your Desk”
Once upon a time, 3D printing was about churning out tiny Yodas and Pikachus, but these days, useful things are regularly 3D printed too. A great example is this centrifugal water pump that can really deliver the juice, courtesy of [Connor].
The pump’s housings and impeller are all 3D printed in PLA, as well as the inlet which is designed for a 2L soda bottle to screw into. Gaskets are printed in pliable TPU to help seal the housings. There are a few ball bearings inside to allow the impeller to spin nicely, too, with hex head fasteners used to hold everything together and a long bolt used as the main impeller shaft. Notably, no shaft seal is included, so the pump does leak a bit, but it’s not a major concern assuming you’re just pumping water and don’t mind spilling a bit of excess. Turned with a drill at 1800 rpm, the pump is able to achieve a flow rate of 13 litres per minute, or a maximum head of 1.2 meters. The design is on Onshape, for the curious.
It’s a great example of how 3D printing can allow the creation of machines with complex geometry without the need for advanced machining skills. Instead, all the hard work is done on the CAD side of things. We’ve seen 3D printed pumps put to real work before, too, like this fertilizer dispenser. Video after the break.
Continue reading “3D Printing A Centrifugal Water Pump”
Once upon a time, 3D printing was more of a curiosity than a powerful tool, with many printing trinkets and tchotchkes rather than anything of real use. However, over the years as technology and techniques have progressed, we now see more application-ready builds. This water pump from [Let’s Print] is a great example.
The pump consists of two major pieces – a drive unit, and an impeller. The drive unit consists of a gearbox that combines the power of eight electric motors, driving a single shaft. This is all achieved with striking yellow ABS gears in a black housing. The build video does a great job of explaining how to make the project work with different motors, and how to properly use the bolt adjuster to set the backlash on the gear train. The drive unit is then used to turn a 3D-printed impeller pump which is capable of delivering a great deal of water very quickly.
When fired up, the leaky assembly makes an awful racket and a huge mess, but sure as heck shifts a lot of water while it does so. Watching the water spray off the gears as it leaks through the bearings is a great sight, and it’s clear that the device works well. We’d love to see a cost and performance analysis of this pump versus a commercial offering.
While it’s certainly not the most rugged build, it’s a fun one that nevertheless gets the job done. We’d love to see this running a foam machine or a classic slip and slide. Video after the break.
Continue reading “Eight Motors Can Sure Pump A Lot Of Water”
Having a few plants around is a great way to liven up your living and/or working space. They look nice, you get to watch them grow and change, and some types of plants can actively improve the room’s air quality. But let’s face it — even the easy ones require a baseline level of care that can easily fall by the wayside. After all, the poor things can’t scream out for water or get up and find a sunnier spot for themselves.
[Ine Hocedez] was tired of watching her plants die and not knowing why. The two main culprits involve water and light, though there can be other issues like soil pH and bugs. It’s easy to get the balance wrong, so why not automate everything?
Plant’m is a complete, portable package that [Ine] designed for a school project. A soil moisture sensor dictates the watering schedule via Raspberry Pi, and water is automatically pumped from an elevated tank.
The lamp is meant to supplement the sunlight, not replace it. But that’s the real beauty of this botanical box — [Ine] can just pick it up and try a different spot if the plant droops or shows burnt spots.
Got the sunlight part down for your plant, but can’t remember to water it? Re-purpose an old Keurig and give it an automatic drip.


Agencies propose new standards for AVMs
On June 1, the CFPB joined the Federal Reserve Board, OCC, FDIC, NCUA, and FHFA in issuing a notice of proposed rulemaking (NPRM) to implement quality control standards mandated by the Dodd-Frank Act concerning automated valuation models (AVMs) used by mortgage originators and secondary market issuers. Specifically, institutions that engage in certain credit decisions or make securitization determinations would be required to adopt quality control standards to ensure a high level of confidence that estimates produced by an AVM are fair and nondiscriminatory. Other requirements would necessitate institutions to protect against data manipulation and avoid conflicts of interest. Institutions would also be required to conduct random sample testing and reviews and comply with applicable nondiscrimination laws. The agencies acknowledged that while advances in AVM technology and data availability may contribute to lower costs and reduce loan cycle times, institutions’ reliance on AMV technology must not be used as an excuse to evade the law.
CFPB Director Rohit Chopra explained that, while AVMs rely on mathematical formulas and number crunching to produce estimates (and are often used to “check” human appraisers or used in place of an appraisal), they can still embed the human biases they are meant to correct. This is due in part to the data fed into the AVMs, the algorithms used within the machines, and biases and blind spots attributed to the individuals who develop the models, Chopra warned, commenting that AVMs can actually “make bias harder to eradicate in home valuations because the algorithms used cloak the biased inputs and design in a false mantle of objectivity.”
Chopra went on to explain that inaccurate or biased algorithms can lead to serious harms to consumers, neighborhoods, and the housing market, and may also impact the tax base. A focus common to all the agencies, Chopra said, is ensuring that automated systems and artificial intelligence modeling technologies are developed and used in accordance with federal laws to avert discriminatory outcomes and prevent negative impacts on consumer financial stability.
Comments on the NPRM are due within 60 days of publication in the Federal Register.


March 30, 2011
Hokies looking at rising TE Dockins
Recruiting is picking up for tight end Kyle Dockins out of Virginia Beach (Va.) Landstown. Plenty of colleges are interested in the 6-foot-4, 200-pounder and Virginia Tech is one such program that is looking long and hard.
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|sajid_chauhan_81||-- 28-05-2009 @ 5:54 PM|
Bismillah walhamdulillah was salaatu was salaamu alaa rasoolullah
Pdf is attached!
|Hamdi||-- 31-12-2009 @ 7:58 PM|
asalamu alykum wa rahmatullaahi wa barakatu
afwaan i can't see the pdf file, would it be possible if you posted it up again as i am in need of it.
Umm yahya bint muhammed
|sajid_chauhan_81||-- 06-01-2010 @ 4:41 AM|
Wa 'alaykum as salaam warahmatullahi wabarakaatuh,
Please click here to read the pdf.
|sajid_chauhan_81||-- 28-01-2010 @ 4:19 AM|
Our brother Moosaa Richardson (salafitalk id: Moosaa) whilst reading through the book entitled, "Methods the People of Falsehood Use to Establish their Baatil - Exposed" by [url=http://salafitalk.net/st/viewmessages.cfm?Forum=19&Topic=9323]Shaykh Muhammad Ibn 'Umar Bazmool[/url], may Allah preserve him, mentioned a very important issue concerning reading the books of the innovators. Many of us have heard the erroneous statement, "take the good and leave the bad", which in essence does not make any sense at all in this situation. This act of taking the good and leaving the bad would require a person, in advance, to have knowledge of the good and the bad to be able to filter out what would harm him. If he had this ability he wouldn't need this source at all in the first place.
Shaykhul-Islaam Ibn Taymiyyah, may Allaah have mercy on him, commented on one of the most famous explanations of the Qur'aan from the Mu'tazilah entitled, "al-Kashaaf". This tafseer has been read by many, both in the past and the present who fell for the high level of eloquence and literature in this book. Similarly today we find many reading and quoting from the deviant Sayyid Qutb and his misguided tafseer, "In the Shade of the Qur'aan" (Fi Zilal al-Qur'an). Again, people are not basing this on its concurrence to the sunnah, but rather they are attached to the eloquence exhibited by the author.
Please click [url=http://www.troid.org/media/audio/samples/MR27.2_Ibn%20Taymeeyah%20on%20al-Kashaaf.mp3]here[/url] to listen to the mp3 & ponder on what Shaykhul-Islaam Ibn Taymiyyah had to say about this book (al-Kashaaf) and those who read it - An Important Principle to Understand!
|dksadiq||-- 20-02-2011 @ 9:42 AM|
jazaakAllaahu khayraa akhee.


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Global Imbalances, Exit, Inflation, Tipping Points, Chinese History, Vancouver’s Bubble, Us & Them, Bob Rae, Squeezed
The body blow that the global economy took from the financial crisis of 2007-2008 was nursed by unprecedented monetary and fiscal intervention by both high and low income countries.
The question facing monetary and fiscal authorities, as well as investors is, 'what comes next'?
This is particularly the case since despite these actions high income countries face a myriad of challenges consistent with weak economic growth namely anemic job growth and fiscal emergencies.
At the same time, because of these actions low income countries face a myriad of challenges consistent with strong economic growth namely accelerating inflation.
Important articles that examine the policy challenges ahead, as well as the difficulty of pinning down tipping points, why China has the year 1679 in mind and an eye on the Bahamas, Vancouver's amazing property bubble, how Adrian Dix will position the BC NDP, Bob's waiting game, and how inflation bites.
Martin Wolf sounds the alarm.
Financial Times – Faltering in a Stormy Sea of Debt
It is astonishing that Standard & Poor’s can say anything about the best-known debt class in the world that is deemed to add value.
So just how does the Fed execute the exit?
Financial Times – US: When Timing is All
Just over a year ago, Ben Bernanke went to testify on Capitol Hill.
Quote worth noting.
“Much depends on circumstances, and policy rules come in many different flavours, but simple examples used by the Fed suggest a need to tighten policy by the time the unemployment rate reaches 8 per cent and core inflation hits 1.5 per cent – and probably somewhat sooner.“
Pdf below -- When Will the Fed Take the Punch Bowl Away?
Asia Sentinel – Hot Money Flows Into Asia Again
It is not just China that has been experiencing massive increases in money supply propelled by inward flows of money. Most of Southeast Asia is seeing the same phenomenon
What drives inflation expectations?
Federal Reserve Bank of New York -- What Is Driving the Recent Rise in Consumer Inflation Expectations?
The Thomson Reuters/University of Michigan Survey of Consumers (the “Michigan Survey” hereafter) is the main source of information regarding consumers’ expectations of future inflation in the United States.
Quote worth quoting.
“In sum, our research shows that expectations of higher nominal wage growth or concerns about increased growth of nominal government debt are unlikely to be behind the recent increase in short-term inflation expectations reported in the Michigan Survey. Instead, we suggest that this rise in inflation expectations reflects two factors: (1) sharp expected increases in food and especially gasoline prices and (2) the use of a survey question (“prices in general”) that results in reported expectations being more sensitive to these types of price change.”
The CIA famously missed the fall of the Soviet Union and the Arab Spring. It’s hard to blame them, calling tipping points is hard.
New York Times – Of Men and Last Straws
When the C.I.A. was criticized for not predicting the popular uprisings that are now roiling the Arab world, its director, Leon Panetta, was quoted as saying that although you can describe the tectonic fault lines that lie beneath the surface of the earth, you cannot predict the exact moment that an earthquake will arrive.
Why China sees danger behind the Dalai Lama’s retirement announcement just like in 1679.
New York Review of Books -- The Dalai Lama’s ‘Deception’: Why a Seventeenth-Century Decree Matters to Beijing
The Dalai Lama’s recent announcement of his planned retirement was not well received by China’s Foreign Ministry, whose spokeswoman described it as an attempt “to deceive the international community.”
Chinese construction companies make their way to the Bahamas. Thanks to David of Victoria for sending this in.
UPI – Chinese Takeaway
While World Bank President Robert Zoellick warns that the world is "one shock away from a full-blown crisis," China has broken ground and taken over the economic future of a country whose nearest island to the U.S. mainland is Bimini, only 50 miles away.
The Vancouver property bubble.
gurufocus -- There Is a Chinese Housing Bubble All Right; It Just Happens to Be in Vancouver, Canada
I’m not the sharpest knife in the drawer, but some things are just so obvious that even I can easily see it. And one thing that is obvious to me is that Vancouver housing prices are just not right.
Gary Mason ponders how Adrian Dix will position the BC NDP. Us and Them.
Globe and Mail -- B.C. NDP leader advised to ditch old campaign playbook
Adrian Dix would likely be a shoo-in to lead his B.C. New Democrats over the governing Liberals in the next general election if all it took to win was hard work and earnestness.
The Hill Times – Rae positioning himself 'if Iggy falls on his sword,' says York University professor Drache
With Harper heading for another minority government—and some say perhaps, just maybe, a slim majority—it might not be long before Liberal Leader Michael Ignatieff heads back to the halls of higher learning.
Ottawa Citizen -- Skyrocketing prices put crunch on families
A seven-cent jump in the cost of a cup of coffee at Tim Hortons is the least of Lisa Greaves' worries.
|When Will the Fed Take the Punch Bowl Away.pdf||90.69 Ko|
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Twin Virtues: Inequality of Outcomes & Equality of Opportunity©
Ultimately, the most successful societies find the balance between the twin virtues of inequality of outcomes and equality of opportunity.
The new politics must marry the twin virtues of unequal outcomes and equality of opportunity.
When too few get too much everybody loses.
Feminism is about women living their lives on their own terms, marshalling the resources of the society to make that possible, and men embracing this as vital to a successful society and their own liberation.
Can it be that striving for equality of opportunity however imperfect the process not only benefits the individual but also creates benefits for the society that are unintended but wonderful?
Economics must be a 'moral enterprise' as much as politics claims to be. Economic outcomes need to be framed in terms of right and wrong not just efficiency if only because these often align in surprising ways that are good for society and the economy.
My vision of Canada is that any Canadian child from a family of limited circumstance can expect to have a chance at lifetime of unlimited opportunities.
Free trade is a wonderful thing. Time and time again economists have proven that free trade creates enormous wealth for each country 'on the whole'. Historians have shown that free trade is usually associated with rising political, social and cultural liberty. The perennial problem is that free trade always creates tremendous disruption for thousands even millions of individuals often concentrated in one geography, and where the state is idle, not investing in best in class instruments of social justice, free trade can be a permanent ticket out of the middle class, down, not up.
Tax policy should be founded on the principle of generating steady tax revenues sufficient to maximise environmentally sustainable economic growth in order to fund fair government.
Public policy should be designed to decrease inequality before the law and increase equality of opportunity.
Capitalism is not the problem; the problem is what we do with capitalism.
Content is always more difficult to argue than conspiracy.
Let the state regulate and the market operate (most things).
Welfare strategies are best designed as a hand up, not as a hand out.
Political debate should not be fact free fighting.
Explanation lasts longer than eloquence.
Always favour empowerment over dependency.
The most enduring public figures are embraced for the causes they fought for and not the concept of themselves they hoped others would remember them by.
Find your voice and don't be the echo of somebody else.
It is possible to operate on two different levels: the practical, cautious and conservative; and the realm of ideas, open, free, and radical.

domain: news


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- High-Resolution Profiling of Histone Methylations in the Human Genome
Cell, Volume 129, Issue 4, 18 May 2007, Pages 823-837
Artem Barski, Suresh Cuddapah, Kairong Cui, Tae-Young Roh, Dustin E. Schones, Zhibin Wang, Gang Wei, Iouri Chepelev and Keji Zhao
SummaryHistone modifications are implicated in influencing gene expression. We have generated high-resolution maps for the genome-wide distribution of 20 histone lysine and arginine methylations as well as histone variant H2A.Z, RNA polymerase II, and the insulator binding protein CTCF across the human genome using the Solexa 1G sequencing technology. Typical patterns of histone methylations exhibited at promoters, insulators, enhancers, and transcribed regions are identified. The monomethylations of H3K27, H3K9, H4K20, H3K79, and H2BK5 are all linked to gene activation, whereas trimethylations of H3K27, H3K9, and H3K79 are linked to repression. H2A.Z associates with functional regulatory elements, and CTCF marks boundaries of histone methylation domains. Chromosome banding patterns are correlated with unique patterns of histone modifications. Chromosome breakpoints detected in T cell cancers frequently reside in chromatin regions associated with H3K4 methylations. Our data provide new insights into the function of histone methylation and chromatin organization in genome function.
Summary | Full Text | PDF (2986 kb)
- Glimpses of the Epigenetic Landscape
Cell Stem Cell, Volume 4, Issue 1, 9 January 2009, Pages 1-2
Xiaohua Shen and Stuart H. Orkin
SummaryIn this issue of Cell Stem Cell, Cui et al. (2009) provide snapshots of histone modification maps for two different stages of human blood cell development. Revealing chromatin-state maps in model cell types will provide an important framework in which to consider epigenetic controls at molecular and systematic levels.
Summary | Full Text | PDF (241 kb)
- Prdm3 and Prdm16 are H3K9me1 Methyltransferases Required for Mammalian Heterochromatin Integrity
Cell, Volume 150, Issue 5, 31 August 2012, Pages 948-960
Inês Pinheiro, Raphaël Margueron, Nicholas Shukeir, Michael Eisold, Christoph Fritzsch, Florian M. Richter, Gerhard Mittler, Christel Genoud, Susumu Goyama, Mineo Kurokawa, Jinsook Son, Danny Reinberg, Monika Lachner and Thomas Jenuwein
SummaryHeterochromatin serves important functions, protecting genome integrity and stabilizing gene expression programs. Although the Suv39h methyltransferases (KMTs) are known to ensure pericentric H3K9me3 methylation, the mechanisms that initiate and maintain mammalian heterochromatin organization remain elusive. We developed a biochemical assay and used in vivo analyses in mouse embryonic fibroblasts to identify Prdm3 and Prdm16 as redundant H3K9me1-specific KMTs that direct cytoplasmic H3K9me1 methylation. The H3K9me1 is converted in the nucleus to H3K9me3 by the Suv39h enzymes to reinforce heterochromatin. Simultaneous depletion of Prdm3 and Prdm16 abrogates H3K9me1 methylation, prevents Suv39h-dependent H3K9me3 trimethylation, and derepresses major satellite transcription. Most strikingly, DNA-FISH and electron microscopy reveal that combined impairment of Prdm3 and Prdm16 results in disintegration of heterochromatic foci and disruption of the nuclear lamina. Our data identify Prdm3 and Prdm16 as H3K9me1 methyltransferases and expose a functional framework in which anchoring to the nuclear periphery helps maintain the integrity of mammalian heterochromatin.
Summary | Full Text | PDF (1197 kb)
Copyright © 2009 Elsevier Inc. All rights reserved.
Cell Stem Cell, Volume 4, Issue 1, 80-93, 9 January 2009
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Chromatin Signatures in Multipotent Human Hematopoietic Stem Cells Indicate the Fate of Bivalent Genes during Differentiation
1 Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
2 Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
3 Department of Physics, The George Washington University, 725 21st Street NW, Washington DC, 20052, USA
4 These authors contributed equally to this work
- Histone modifications have been implicated in stem cell maintenance and differentiation. We have analyzed genome-wide changes in gene expression and histone modifications during differentiation of multipotent human primary hematopoietic stem cells/progenitor cells (HSCs/HPCs) into erythrocyte precursors. Our data indicate that H3K4me1, H3K9me1, and H3K27me1 associate with enhancers of differentiation genes prior to their activation and correlate with basal expression, suggesting that these monomethylations are involved in the maintenance of activation potential required for differentiation. In addition, although the majority of genes associated with both H3K4me3 and H3K27me3 in HSCs/HPCs become silent and lose H3K4me3 after differentiation, those that lose H3K27me3 and become activated after differentiation are associated with increased levels of H2A.Z, H3K4me1, H3K9me1, H4K20me1, and RNA polymerase II in HSCs/HPCs. Thus, our data suggest that gene expression changes during differentiation are programmed by chromatin modifications present at the HSC/HPC stage and provide a resource for enhancer and promoter identification.

domain: biology


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Kapil Sharma To Take A 'Short Break' From His TV Show To Welcome His Second Child With Ginni Chatrath
The Kapil Sharma Show is speculated to go off-air soon and while most of its viewers will have mixed reactions after reading this news, the host himself is not very sad about it. You must be wondering, why?! The reason behind the decision will come as a khush khabri to you and you'd want to say 'congratulations' immediately. Kapil Sharma has finally revealed that he going to be a dad for the second time and that is why he has decided to take a short break from his comedy talk show.
Recently the Kis Kisko Pyaar Karoon actor held a Q&A session with his fans on Twitter and answered all the questions. A follower asked the reason behind the actor's decision to end TKSS and the host heartily replied that it was because he wanted to spend more time with his wife, Ginni Chatrath, who is currently pregnant and is in her third trimester.
The actor wrote, "Bcoz I need to be there at home with my wife to welcome our second baby."
The show is going off-air in February this year, Kapil confirmed that he is taking this break temporarily and will be back soon with new & creative changes. Here's what he said:
As per the recent reports, one of the members related to the show said in an interview, " Kapil Sharma's wife Ginni is expecting their second child and the break would be ideal for him to stay at home and focus on giving quality time to the family. This break will give him the much-needed time to spend with family. The show too can return with more entertaining content after a three-month break."
While Kapil just confirmed the happy news officially, his fans were guessing the same for a very long time. Last year, a Karva Chauth video shared by comedian & friend Bharti Singh on her social media was taking rounds on the internet, where her followers spotted Ginni with a baby bump. It seems the soon-to-be mom had been consciously keeping the details of her second pregnancy under the wraps and we can totally understand her need for privacy at this time.
Feature Image: Instagram
Text By: GirlStyle India

domain: celebrity


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Whenever I hear about a new Pixar movie, I get excited. Maybe Cars 2 wasn't up to the incredibly high standards the studio set with The Incredibles and Wall-E, but it's still more entertaining than 90 percent of movie-like products extruded every year. Months ago, when I heard about Inside Out, I was a little dubious. The concept of personifying the dueling voices in your head as you debate how to get through life was tried in a short-lived TV series from the 1990s called Herman's Head, not to mention the infamous sperm paratrooper sequence in Woody Allen's Everything You Always Wanted To Know About Sex, But Were Afraid To Ask. Could the crack troops at Pixar successfully mine this hackneyed premise, or was this going to be another Monsters University misfire?
You betcha they could! Inside Out is wall-to-wall brilliance that will be spoken of alongside Toy Story and Up as the best of Pixar's legacy.
The little girl whose head we're inside is named Riley (voiced by Kaitlyn Dias) She's being piloted from a cerebral control room by a team of emotions led by Joy (Amy Poehler). Riley's reactions to the events of her life are determined by a running debate between Joy, Fear (Bill Hader), Sadness (Phyllis Smith), Disgust (Mindy Kaling), and Anger (Lewis Black, obviously). Things are going along fine for the happy 11-year-old until her family moves from small-town Minnesota to San Francisco. The family encounters irksome but predictable, problems adjusting to the new environment. The moving van with all of their possessions gets lost. The house they move into isn't as nice as the one they left behind. People in San Francisco put broccoli on pizza.
Riley's bridge crew works to keep her on track with Joy at the helm, but as things get hairy, the emotions find themselves on a sinking ship. An accident throws Joy and Sadness out of Headquarters, leaving Fear, Disgust, and Anger alone to run the show. As Riley's young life starts spiraling out of control, the opposites Joy and Sadness must work together to find their way through her memories and unconscious mind and return to the control room.
Pixar veteran Pete Docter is Inside Out's ostensible mastermind, but in the famously collaborative Pixar spirit, he shares his director's credit with animator Ronaldo Del Carmen. Their work visualizing abstract psychological concepts is creative, fun, and illuminating. Both Riley's drab, everyday existence in San Francisco and the riot of color and shapes in her head are perfectly rendered, and the stories told in both environments complement and inform each other. Every detail has been thought through and perfectly executed. There are references to Chuck Jones, Hayao Miyazaki, and early Disney collaborator Ub Iwerks, as Sadness and Joy travel through Imagination Land and the experimental Abstract Thought chamber. There's not a false note anywhere in the talented voice cast, but Poehler and Richard Kind, who plays Riley's long-neglected imaginary friend Bing Bong are the two standouts. There's even a Frank Oz voice cameo!
Like classic Looney Tunes, Inside Out is ostensibly directed at kids, but speaks even deeper volumes to adults. It's funny and exciting, and its lessons go down easy. Significantly, the film posits that the worst case scenario is not a mind consumed with sadness, but one that can no longer feel anything. Joy's ultimate embrace of the other emotions to create a richer life experience for Riley is both moving and sharply observed. Docter also takes the occasional aside to look at the emotional debates going on in the minds of characters other than Riley to emphasize that everyone has his or her own struggle. Its central theme of staying aware of the different emotional and cognitive forces pulling you to and fro as you go through life seems like an extremely valuable lesson for children. Frankly, it's pretty valuable to me, too. Inside Out is a movie I wish I had seen a long time ago.


Related Program: KBIA Newscast Newscast for April 30, 2013 By Andrew Yost • Apr 30, 2013 Related Program: KBIA Newscast TweetShareGoogle+Email Listen Listening... / 3:01 Regional news coverage from the KBIA Newsroom, including: Mo. Senate passes additional tax legislation Mo. House approves Medicaid inspection committee Mo. House gives first round approval to criminal code overhaul Mo. House wants to expand rights of gun owners with new bill TweetShareGoogle+EmailView the discussion thread.


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Did Abraham Lincoln Smoke Pot?
After all, this was an era where hash was believed to expand the mind, when hemp fabric was used all over.
You frequent the internet long enough, and you hear a lot about famous people who smoked pot, like Louis Armstrong, David Bowie, and Kevin Smith. The more well-known, the more shocking it is when you hear they smoked some weed.
But Abraham Lincoln?
A popular quote online indicates that Abraham Lincoln might've smoked marijuana in his pipes. After all, this was an era where hash was believed to expand the mind, when hemp fabric was used all over. Is it that difficult to believe that Abraham Lincoln smoked weed? Or, perhaps, is this just another internet urban legend.
Did Abraham Lincoln smoke pot?
While there are many people who would say that it's highly possible that Abraham Lincoln did smoke weed based on mindsets toward cannabis at the times (it was neither illegal nor looked down upon during Lincoln's presidency), there is little hard evidence for it.
The only real evidence comes in the form of a quote attributed to Lincoln that's floated along the net:
Two of my favorite things are sitting on my front porch smoking a pipe of sweet hemp, and playing my Hohner harmonica.
The quote supposedly came from a letter Lincoln wrote to the Hohner Company, a letter written by most estimates in 1855. Supposedly, this served as an endorsement of Hohner harmonicas, the same way Michael Jordan and Hanes Underwear go hand-in-hand.
If this quote is true, it may be very clear that Abraham Lincoln smoked marijuana in his pipe. Or at the very least, the guy enjoyed the the nice buzz of some hemp oil. If this quote is real, then the question "Did Abraham Lincoln smoke pot?" should be definitively answered.
If a letter like this existed, surely it would be preserved, or at the very least be utilized by the Hohner Company. This sort of endorsement would no doubt be spread in newspapers or the like. Lincoln promoting hemp smoking would, no doubt, make headlines, especially once he became president, which didn't happen until 1860, a whole five years before the letter was written.
But there in lies one issue: Hohner didn't make harmonicas until two years after 1855.
Okay, so maybe the letter is incorrectly dated. We can reconfirm when it was written when we have our hands on it.
Okay, but where is it?
The truth is that this letter simply does not exist. There are no records of it existing before the age of the internet – no definitive proof, anyway.
In fact, if not for a Huffington Post article presenting the quote as truth, there'd be no authoritative source for this quote. And guess what? The quote has no real source. No evidence that it ever existed at all.
Furthermore, most accounts of Lincoln indicate that not only did he not smoke marijuana, but he didn't even use a pipe nor cigarettes nor a cigar. The man barely drank. Honest Abe was as straight-laced as you can get.
A Shadow of a Doubt
But we can never definitively prove Abraham Lincoln did not smoke pot. There's no record of his every waking moment, and no one stared at him to make sure he never lit up a hemp pipe.
But, likewise, there is no evidence that he did smoke weed, either.
In the absence of any proof, it is time to answer the question.
"Did Abraham Lincoln smoke pot?"
In all probability, no.
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Obsessive writer fueled by espresso and drive. Into speculative fiction, old books, and long walks. Follow me at twitter.com/AGramuglia
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Prior to leaving in 2015, Leakes was with the show for eight seasons. Her friend, Kim Zolciak-Biermann, has reportedly already signed a contract to re-join the show. A source says she’s making less than Leakes, however. “NeNe has already declared that she expects to be making more money than Kim,” said the source.
Rumors are also swirling that Leakes is in talks to do a spin-off show and/or special. There is no information yet on whether this other project will involve Zolciak-Biermann. There’s also no additional details on if new cast members or other returning ones are set to join RHOA following Phaedra Parks’ exit.


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domain: economics


This post revised November 2012 with updated Dragon version details for Mac and Windows.
Another update, early 2017. The below pretty much holds true still but there have been some advancements in voice-to-text software since this blog was originally written. We are starting to see some success with transcribing one on one interviews. Multi speakers, over talking each other with lots of background noise will always be an issue for voice to text software. Clear here to see our 2017 post with an example of voice to text for a one on one interview.
Another update 2019. ASR or Automatic Speech Recognition for interviews and meetings now possible with Amazon AWS Transcribe – see this post.
Latest update September 2020. Microsoft allow voice-to-text of meetings and interviews in Word and can be used on a Mac or a PC. Details and a demo video in this blog post dictat.es/word-transcribe – oh and yes and it’s free and works really well.
No, is the short answer. [We wrote this blog post 9 years ago and it is still relevant. Dragon is falling behind compared to the cloud based solutions offered by Philips (SpeechLive), AWS (Transcribe), Google (Voice Typing in Google Docs), Word online from Microsoft (works on a Mac and PC).] Voice or speech recognition software will only successfully work with one spoken voice and that spoken voice, for best results, needs to have trained the software to understand their voice and style of speaking known as creating a voice profile. Most people who use voice recognition software typically pop on a headset and mic and chat away to their Windows PC or Mac and watch as their voice is magically (or using the Dragon voice recognition engine if you don’t believe in magic) converted to text.
Voice recognition is currently going through a spike in popularity, especially since the iPhone 4S was released back in October 2011 running iOS5 with Siri. Siri has definitely helped raise the awareness of just how good voice recognition technology has evolved over the last couple of years, Nuance being the company leading the way in this technology on Mac, Windows and now inside both iOS5 and iOS6 working closely with Apple.
Most of us now has an iPhone or smart phone which is capable of recording audio and most who need to capture important meetings or interviews also have a high quality digital voice recorder. Dragon NaturallySpeaking version 12 Premium and Professional edition on Windows and the recently released Dragon Dictate 3 for Mac can take recorded audio and transcribe it, but that is only for the single voice trained person who is speaking. So it is understandable that the leap is often made that if it can transcribe one voice it can transcribe many, not so. The technology is not there yet and in my opinion won’t be for quite some time.
Nuance on their website cleverly have a couple of pages dedicated to Transcribing Interviews or Transcribing Lectures using a technique called voice writing or parroting. The idea is simple, you record your interview, meeting, lecture or whatever it is that has multiple voices or a single voice that you can not get trained in Dragon (possibly the voice of someone making a speech or presenting at a conference). Then when you are sitting in front of your Windows PC or Mac you listen to your recorded audio and you speak what you hear. Therefore it is your trained voice that Dragon hears as you are repeatings other peoples words from your recording. Sounds simple doesn’t it – it isn’t, I have tried it a few times and have become extremely frustrated. You may find that the voice you are listening to is too fast for you to remember and repeat back which means you are constantly stopping and rewinding the audio, which on an iPhone app or basic digital voice recorder is not always that easy. You will likely often have to stop the audio to correct mistakes made by Dragon, maybe when unfamiliar names or terms are used which have not been trained into your user profile. It will work but it does take a lot of concentration and a large amount of practice, you can give it a try, just search YouTube for a boardroom meeting and see if you can repeat what you hear while wearing a headset and mic.
So what are your practical options for transcribing audio or video of meetings and interviews or in fact any audio that you need turned from voice to text?
Option 1 – Type The Audio Yourself
You could transcribe the audio yourself using some specialised transcription software to help you, transcription is the process of typing what you hear. When I say help it won’t actually do the work of typing it for you but it will assist greatly with the audio playback. For example if you are a slow typist you could slow the speed of audio playback down to match your typing speed or conversly also speed up the audio if your fingers are a blur when you type. Using transcription software you can also easily rewind the audio, again set up to match your typing ability so you could either rewind back half a second or if you are a poor typist like me rewind the audio back up to 5 seconds. The biggest benefit of using transcription software is that audio can be controlled from inside the word processor that you are typing in. By that I mean using a USB connected foot pedal or pre-defined keys on your keyboard you can stop/play/rewind the audio without leaving the document that you are typing. This is a huge time saver, often people try to transcribe using Windows Media Player or Quicktime for their audio playback and they have to constantly switch between they document to the audio player to stop/rewind/play and then back to the document which adds a considerable amount of time to the whole transcribing process.
Pros Of Doing It Yourself
- Cost, from the point of view that you are not paying someone else to do the work.
- Cost, from the point of view that transcription software is free or relatively cheap depending on what you buy.
Cons Of Doing It Yourself
- It is hard work and not as easy as it sounds.
- Transcription typing does take a long time even if you are experienced.
Just as an indication of how long transcription takes, a good quality one hour audio file of an interview between two people would take an experienced transcription typist around 2-3 hours to transcribe. If you are not experienced expect that to rise to 4-5 hours and without the help of transcription software even longer.
- Express Scribe from NCH Software – $FREE
- Express Scribe Pro from NCH Software – approx. AU$40 – Click Here To Buy Express Scribe PRO – Plays .dss .ds2 .dct .dvf .avi .mov .wmv audio and video files.
- Olympus AS-2400 Digital Transcription Kit – Includes software, headset and USB foot pedal – RRP AU$425 but usually it sells online for less. Windows & Mac compatible.
Option 2 – Outsource To A Professional Transcription Service
If you need your audio transcribed quickly and accurately then this option is for you. Just Google transcription service and see how many businesses are listed both organically and in the paid Google ads. Transcription has become a boom business over the last few years and that makes total sense. With the availability and high quality of digital voice recorders and iPhone apps just about everyone is recording their meetings, interviews, podcasts, vodcasts, focus groups, lectures, letters, assessments the list goes on. It is great to have a record of your meeting and the like stored digitally which can be easily shared within your business on your intranet or with the world on the internet but more often than not a written transcript is also required for offline reading, compliance or for public record. There are all kinds of reasons audio and video is transcribed into text these days.
This is where a professional transcription service can come in to help you. Simply send them your digital audio or video via the internet and they can set to work using their team of experienced transcription typists to convert your voice to text. Here is a security tip, always make sure that the transcription service you use has their own secure file server and that the data you send them is encrypted either using FTPS (not FTP) or HTTPS (not HTTP) – this is important for two reasons. 1. your audio/video is encrypted as it travels across the internet from you to their servers. 2. by ensuring they run their own secure server they will have full control and access over what happens on that server. Many transcription services use third party providers like SendThisFile.com and they nor you have any control over your data on that third parties servers. Ask any transcription service that you approach about their security and file transfer mechanisms. Many still use FTP and not FTPS, transferring files across FTP alone does not encrypt the file contents, be it audio, video or worse still your transcribed documents.
Any good professional transcription service will turn your audio around quickly and the final transcript will very accurate. Typically there are two phases to the transcription process; phase 1 is the transcription typist who listens and types your audio/video to text. Phase 2 is a quality assurance phase, a proofreader will listen to your audio and proof against what has been transcribed. This double verifies the typists work and the document can be formatted to your specific requirements.
As audio and video for transcription is mainly digital you can utilise the services of a transcription company anywhere in the world, you may want to do this for cost benefit reasons but more often than not to take advantage of time zones. Many UK and US businesses will use the services of Australian based transcription companies for just this reason as Australia tends to work their business day as Europe and the US sleep.
- Speed, this is a transcription services core business. Reputable companies will turn around audio and video very quickly.
- Accuracy, again as a core business this is how transcription services are rated from a customers point of view. A good transcription firm will always produce high quality accurate transcriptions because of the two phase approach.
- Ability to adapt, regardless of how much audio or video you send you should always expect the same fast, accurate turn around of transcripts.
- You don’t have to do it so you can focus your time on more productive work.
- Cost is the only con, you are paying for a service so compared to you doing it yourself there will be a cost involved. Obviously the larger more reputable transcription companies will have different rates from the work from home type of micro transcription service.
So there you have it ! Reasons why Dragon NaturallySpeaking for Windows or MacSpeech Scribe for Apple Mac are not good for transcribing meetings or interviews and the options you have open to you to convert recorded audio or video into text.