To register and apply for workshops and preparatory policy meetings see the links below.
In light of the International Day for the Elimination of Racial Discrimination (21 of March), the European Network Against Racism and Members of the European Parliament, alongside Open Society-Europe and Central Asia and other partners are co-hosting the second EU Anti-Racism and Diversity Week in the European Parliament, Brussels 20-22 March 2023.
Join us for an interesting week where we will discuss racial discrimination in Europe, and how different forms of structural racism manifests. We will talk about existing policy tools to counter racism, and evaluate the ongoing European anti-discrimination agenda.
The week will cover:
- EU Anti-racism action plan and National Anti-Racism Action Plans
- Legislative gaps
- Artificial Intelligence
- Climate Justice
- Intersectional discrimination
- Remembrance and repair etc.
The event is a shared platform for institutions, civil society organisations, anti-racist actors, and activists to come together and lead on solution-based discussions to address structural racism.
The Anti-Racism week will be hosted by MEPs:
- Cornelia Ernst
- Pierrette Herzberger-Fofana
- Romeo Franz
- Samira Rafaela
- Isabel Carvalhais
- Monica Semedo
- Peter Pollak
For more info about the agenda and to register, please click here.


text:
Water was splashing, and mud was flying, and oaths were being sworn, and blows were being struck, when some more men went down into the ditch to help the sergeant, and dragged out, separately, my convict and the other one.
said my convict, wiping blood from his face with his ragged sleeves, and shaking torn hair from his fingers: "I took him
With the universal adoption of Colour, all distinctions would cease; Regularity would be confused with Irregularity; development would give place to retrogression; the Workman would in a few generations be degraded to the level of the Military, or even the Convict
Class; political power would be in the hands of the greatest number, that is to say the Criminal Classes, who were already more numerous than the Workmen, and would soon out-number all the other Classes put together when the usual Compensative Laws of Nature were violated.
But my case was particular; it was by no means proper to me to go thither without money or goods, and for a poor convict, that was to be sold as soon as I came on shore, to carry with me a cargo of goods would be to have notice taken of it, and perhaps to have them seized by the public; so I took part of my stock with me thus, and left the other part with my governess.
He told me was determined to go, but found it would be impossible for him to be discharged time enough for going in the same ship, and which was more than all, he began to question whether they would give him leave to go in what ship he pleased, though he did voluntarily transport himself; but that they would see him put on board such a ship as they should direct, and that he would be charged upon the captain as other convict prisoners were; so that he began to be in despair of seeing me till he came to Virginia, which made him almost desperate; seeing that, on the other hand, if I should not be there, if any accident of the sea or of mortality should take me away, he should be the most undone creature there in the world.
After a short probationary experience of such low convict employments as lime-burning and road-mending, I was advanced to occupations more in harmony with my education.
I went through the superfluous ceremony of a second marriage with Alicia; took stores in the city; built a villa in the country; and here I am at this present moment of writing, a convict aristocrat--a prosperous, wealthy, highly respectable mercantile man, with two years of my sentence of transportation still to expire.
Eight of us, five convicts and three sailors, said that we would not see it done.
An instant later the explosion occurred, though Hudson thought it was caused by the misdirected bullet of one of the convicts rather than the mate's match.
Sonia's letters were full of the most matter-of-fact detail, the simplest and clearest description of all Raskolnikov's surroundings as a convict.
In the last letter Sonia wrote that he had been taken very seriously ill and was in the convict ward of the hospital.
This, however, must happen at the expense of their boys associating entirely with convict
No one save myself knew in that man's lifetime who he was, or whence he came--it was John Edmunds, the returned convict
You thought it was the runaway convict
," observed the priest simply, "because you had read in the newspaper cutting that morning that a convict
had run away.
And now, having brought you up to date in the escaped convict
, the Stapletons, Dr.

domain: literature


text:
Set of 9 holds Triangles (Size M)
Pack of 9 climbing holds triangular-based geometry, essential for "route setting" of complex problems.
These holds offer many possibilities depending on their position, from blunt pinching to inclined walls or positive ledges and placed on their most uncomfortable side, they will force you to work hard on your foot technique to step on those inclined walls.
- Approximate weight of the pack
- Grip type
- Pinch holds
- Size M
- Number of climbing holds
- Recommended hardware (Not included):
- M 10 x 40 mm
- Random. For specific colour, please indicate it in the attached message (Delivery time increase).

domain: hobby


Escort made the announcement this morning that the new member of the Max family of detectors is available for pre-order today. The Max 360 detector sports a new feature that displays the direction in which a radar source is coming from, including front, rear and sides. The feature has been added to the right of the front LCD display in the form of arrows.
Escort has been known for a solid line of detectors that offer an accurate detection response for both radar and laser while auto-detecting false alerts and filtering them out so you’re not spending half your drive hitting the mute button because you pass by a convenience store with automated doors.
Like the four generations of detectors before it, the Max 360 offers built-in GPS that allows you to store a collection of hotspots including red-light cameras, speed cameras and speed traps. You are able to subscribe to a national database to keep your information up-to-date and can manually add locations yourself directly from the detector while driving.
Information is displayed on the front LCD display showing what type of radar or laser has been detected and can display multiple signals when detected due to its dual antenna design. It also displays the speed limit on the road you are currently traveling as well as your actual current speed–based on GPS.
The detector has clear voice alerts that help you better understand what is going without having ever take your eyes off of the road (another feature that has been in-use spanning multiple generations of models).
There is even Bluetooth connectivity for iOS and Android devices that allows you to tap into their real-time “ticket-protection” network, where you can learn about nearby alerts from other users and explore additional information.
They will start shipping on October 19th and for the moment can only be pre-ordered directly from their website.


A Long March-3B carrier rocket carrying the Zhongxing-9B satellite blasts off from the Xichang Satellite Launch Center in southwest China's Sichuan Province, Sept. 9, 2021. The satellite was launched at 7:50 p.m. (Beijing Time) and entered the planned orbit successfully. (Photo by Bai Xiaofei/Xinhua)
XICHANG, Sept. 9 (Xinhua) -- China successfully launched a new satellite from the Xichang Satellite Launch Center in southwest China's Sichuan Province Thursday.
The satellite, Zhongxing-9B, was launched at 7:50 p.m. (Beijing Time) by a Long March-3B carrier rocket and entered the planned orbit successfully.
This launch marked the 388th mission for the Long March series carrier rockets.


As an avid cyclist, January always makes me feel that winter is never going to end. Most winters, there are plenty of distractions, such as cross country skiing, snow-shoeing, and tubing; however, the weather this year has bounced up and down around the freezing mark so much that it's been slush, slush, and more slush, with no hope for any serious winter activity. About the only thing keeping me sane at this point is the indoor riding I've been doing.
Now, let's be clear: indoor cycling is no replacement for the real thing, but it's all some of us have to try to stay in shape and keep The Crazy at bay until Spring. Fortunately, there are some ways to make indoor cycling a little more fun and effective. In my case, I picked up a Fortius "virtual reality" bike trainer three years ago, and have been happily using it to help make it through the winter ever since.
My Fortius unit is several years old now, and Tacx has long-since upgraded the hardware and software. I've been very happy with my Fortius, which says much for the basic concept, and I presume that the revisions have only improved the quality and functionality of the products.
The Fortius VR trainer is produced by a European company called Tacx. The Fortius unit goes far beyond simple magnetic or fluid resistance trainers by combining computer software with dynamic-resistance hardware to provide an experience that comes very close to a "real" outdoor ride.
As you can see above, the Tacx Fortius includes the expected cycle-trainer, though there are obviously some unusual extras involved. First up, the additional hardware on the rear wheel allows the Fortius software to dynamically control the rolling resistance experienced by the cyclist. This means that the software can simulate the effect of riding uphill or downhill in-synch with the display on-screen.
The resistance unit consists of what is essentially an electric motor/generator and a large motor controller to drive the motor. You can see the two components more clearly in the picture below:


text: Vermont Wings welcomes you to one of the most beautiful locations in the world. Lake Champlain is home to many native Vermonters as well as thousands of tourists every summer. Stretching from the Richelieu River in Quebec down past Fort Ticonderoga, Lake Champlain offers many summer fun activities. One way to tour Vermont and see more of its beautiful features is from the air. Take a romantic scenic sunset flight with your significant other, or enjoy a special moment to remember with you and your son or daughter. Whether you're a visitor to Vermont or a current resident, come enjoy a safe and fun new experience in the Lake Champlain Islands of Vermont!

domain: geography


text:
Rising inequalities and decrease in foreign aid funding are to blame for a rise in world hunger, writes Amyrose Forder.
When Sea Watch captain Carola Rakete forced her way into Lampedusa harbour to bring rescued refugees to the Italian shore, she became a symbol of defiance, write our editor Cassie.
In the DRC, the Ebola virus is not only spreading, but intervention has been made difficult by conflicts in some parts of the country.
On Nelson Mandela Day, we look at how his legacy lives on, in South Africa and around the world.
Is the right to a healthy environment a human right? Several court cases, including Climate Case Ireland, are using this argument to make governments legally obliged to take action against climate change.
In Africa, Ethiopia is leading the way in peacekeeping, welcoming refugees from neighboring countries and implementing progressive social measures.
The #BlueForSudan movement has taken social media by storm in recent weeks. But is it really helping the people affected by the humanitarian crisis in Sudan? Rose Aydin reports.
Thousands of protesters in Sudan were violently broken up by military forces, leaving over a hundred people dead and many more injured.
This World Refugee Day, the UN reminds us that wealthy countries need to double their efforts to support refugees globally, as 86% of the refugees worldwide are hosted by developing countries.
Women and girls are major targets of sexual violence in conflict, despite United Nations measures being put in place nearly 20 years ago.

domain: sociology


text:
The traditional March 8 celebration in Oslo will take place digitally this year and will thus not be affected by the new strict anti-corona measures in the capital.
“We have so many people meet, unfortunately,” Oslo Vice Mayor Inga Marte Thorkildsen (SV) told news bureau NTB after the Municipality’s announcement of the new strict corona measures on Sunday night.
The tightening will be introduced due to high levels of infection that have been reported in the capital recently. The measures include closing restaurants and shops, banning events, and urging people to avoid private gatherings. They will be in force from March 2 to March 15.
The International Women’s Day on March 8, which is usually celebrated with parades in Oslo, thus falls in the middle of the lockdown period.
But this year’s celebration has long been planned to take place in a digital format, so the new restrictions will not have a great impact on the event, Thea Borkhus Gabrielsen in the working committee of the March 8 committee noted in an email to NTB on Sunday night.
“The traditional square event has long been planned to be replaced with a digital stream with political appeals and cultural elements,” she said.
Source: © NTB Scanpix / #Norway Today / #NorwayTodayNews
Do you have a news tip for Norway Today? We want to hear it. Get in touch at email@example.com

domain: news


text:
A fight that has pitted Mike Baird against Tony Abbott, a homegrown local against a powerful party insider, and the moderates against the right, will end tonight when a Liberal candidate for the state seat of Manly is preselected.
Tonight’s vote for the seat is expected to come down to two candidates: Mr Abbott’s former campaign manager Walter Villatora and former Manly deputy mayor James Griffin.
Whoever emerges victorious will then vie to take the seat of Manly at the upcoming by-election after it was left up for grabs by the resignation of Mr Baird.
‘Young Baird’ versus party insider
The former premier is supporting Mr Griffin — a man considered to be a younger version of Mr Baird who will continue his work in the electorate.
Mr Griffin was born and bred in Manly and is considered a moderate without having formal ties to the faction.
He has previously been recognised as NSW Young Businessperson of the Year for setting up a social media consultancy firm and currently works for KPMG.
On the northern beaches, one nickname bestowed upon the former councillor is “the spruiker”, referring to Mr Griffin’s unwavering support for Mr Baird.
His challenger — Mr Villatora — is from the right faction of the Liberal Party and is known to be a formidable opponent.
He too has a powerful backer — former prime minister Mr Abbott — who has been very vocal about supporting his friend. Ahead of the preselection, Mr Abbott publicly released letters in support of his friend’s candidacy saying his position was very clear.
It is also the second time Mr Abbott has supported Mr Villatora in a preselection ballot in as many years.
Villatora lost battle for Bishop’s seat
Last year, Mr Villatora was one of two challengers in the preselection ballot against federal member for Mackellar Bronwyn Bishop.
He and Mrs Bishop were both unsuccessful but Mr Abbott’s support for Mr Villatora was further evidence of the bitter rift between the former prime minister and the former speaker.
Mr Villatora has held several roles within the Liberal Party including president of the Warringah Federal Electoral Conference.
He is also a businessman holding several senior management roles across different sectors.
The party insider is pushing for the democratisation of the Liberals and he is viewed as a candidate standing up to the Liberal Party establishment, lobbyists and faction warlords.
His preselection would also be advantageous to Mr Abbott because it secures the right influences in that area of the northern beaches.
The northern beaches is Liberal Party heartland but voters in the Manly electorate are considered more moderate.
Mr Baird was a very popular local member but before he was elected, the seat was held by an independent for four terms. Therefore it is a seat that can’t be taken for granted by the Liberal candidate.
The preselection will take place tonight and the successful candidate will then have less than a month to campaign. The by-election will be held on April 8.


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CNN did a piece today on a trip to Wyoming to find out what everyday people think of Liz Cheney and her role on the January 6th Committee.
Guess how many positive endorsements they found?
The CNN reporter literally says “almost everyone” she talked to wasn’t voting for Liz Cheney and didn’t like what she was doing on the January 6th committee. Big shocker, eh?
Seriously, I think if they had found someone that liked Cheney they would have put that person on the air. But nobody they interviewed was a fan.
Liz Cheney is DONE in Congress.


The valve stem is an important part of the valve, used for transmission, connecting the actuator or handle, moving or rotating directly under the valve core to realize the switching or adjustment of the valve. During the opening and closing of the valve, the valve stem is not only a moving part, a stressed part, but also a sealing part. At the same time, it will be impacted and corroded by the medium, and it will also generate friction. Therefore, when selecting the valve stem material, it must be ensured that it has sufficient strength at a specific temperature, good impact toughness, wear resistance and corrosion resistance. The valve stem is a wearing part, and attention should also be paid to the machinability and heat treatment properties of the material when selecting it. Therefore, many valve stems are usually made of Inconel 718 material.
Inconel 718 stem is resistant to acid corrosion in harsh service environments and high temperature conditions, so it can be used in chemical desulfurization and deacidification of coal in corrosive or acid environments, especially in corrosive environments containing carbon dioxide and hydrogen sulfide. Inconel 718 has very good mechanical properties after machining, so this alloy is widely used in petroleum production, coal mining, aerospace equipment and machinery manufacturing industries. The alloy contains over 50% nickel, about 20% chromium and 3% molybdenum. It plays a vital role in the production of coal chemical industry and the use of equipment. Nickel element makes Inconel 718 more stable, and can prevent chloride ion stress corrosion cracking in strong oxidizing environment. The presence of chromium element improves the oxidation resistance of the alloy, and also improves the corrosion resistance of the material. The presence of molybdenum element reduces the corrosion phenomenon of the alloy and enhances the pitting corrosion resistance in harsh environments.
Stress corrosion cracking is a form of failure caused by the interaction of stress and a corrosive environment. Once stress corrosion cracking is formed, it will propagate at a very high rate, causing structural members to rupture within a short period of time, which is a very dangerous phenomenon. External environmental factors have a very large impact on the stress corrosion performance of Inconel 718 alloy. Inconel 718 alloy has strong stress corrosion sensitivity in boiling magnesium chloride solution at 154℃, so it limits the maximum temperature of Inconel 718 alloy valve stem used in coal chemical industry. In addition, the presence of hydrogen sulfide in the environment also promotes the stress corrosion cracking susceptibility of Inconel 718 alloy in high temperature chlorine-containing environments. At high strength levels, stress corrosion cracking susceptibility increases with increasing hydrogen sulfide partial pressure. Stress corrosion susceptibility is very high at high partial pressures of hydrogen sulfide, especially when the solution contains sulfur.
Inconel 718 alloy is used in the production of coal chemical valve stem material due to its excellent corrosion resistance. Inconel 718 alloy valve stem material generally does not have uniform corrosion and pitting corrosion in the coal chemical production environment. Inconel 718 alloy stems have excellent uniform corrosion resistance in environments containing carbon dioxide and hydrogen sulfide, with corrosion rates below 0.025 mm per year, even at high temperatures. Inconel 718 alloy exhibits excellent corrosion resistance in sour environments. The corrosion rate of Inconel 718 alloy valve stem material in hydrochloric acid solution is 0.1mm/h, and the corrosion resistance of this solution is comparable to that of alloys such as 825 SM2550 and G3. Objectively speaking, the corrosion resistance of Inconel 718 alloy in acid chemical processing environment is sufficient, especially in this working environment, corrosion inhibitors are added to reduce the corrosion rate of the alloy. When the aging temperature increased, the corrosion rate of Inconel 718 alloy in 5% boiling hydrogen sulfide solution decreased slightly, indicating a slight improvement in its resistance to uniform corrosion. However, after the aging temperature reaches 788 °C, the corrosion rate increases and the resistance to uniform corrosion decreases with the increase of the aging time.
Inconel 718 alloy has excellent corrosion resistance, but sometimes it is deeply corroded in harsh acidic environments. Usually, the deeply corroded environment often contains sulfur and oxygen elements. Therefore, inconel corrosion in Inconel 718 alloy stem material often occurs in extremely harsh acid chemical environments. The pitting corrosion resistance of Inconel 718 alloy stem material is comparable to that of duplex stainless steel. Due to insufficient corrosion resistance, stainless steels such as 410 stainless steel, 9Cr1Mo 304 stainless steel, CA6NM and 17-4PH cannot be used. If pitting corrosion occurs on the Inconel 718 alloy valve stem, first review the heat treatment process. Considering that the heat treatment process affects its structure and reduces the pitting corrosion resistance of the alloy valve stem, the heat treatment that has a greater impact on it The process is an aging process, and the aging process involves aging temperature and aging time. Reasonable changes in aging temperature and aging time help to improve the pitting corrosion resistance of alloy valve stems. It is worth noting that the temperature of pitting corrosion does not increase with the prolongation of heat treatment time, but the temperature of pitting corrosion decreases with the prolongation of heat treatment time. The ability to resist pitting corrosion decreases, and the appearance of this phenomenon is related to carbide precipitation and element segregation caused by aging. Aging time and temperature are two important factors in effective aging treatment. Increasing the aging temperature and prolonging the aging time will cause the pitting corrosion resistance of the valve stem alloy material to decrease significantly. On the other hand, the effect of pitting corrosion resistance on the performance of Inconel 718 valve stem in an acidic service environment is not very important, and it is not a key factor limiting the completion of the valve stem function unless the valve stem works in an extremely special environment.
To sum up, the corrosion and cracking behavior of Inconel 718 material valve stem is ubiquitous in the service environment of high acid coal chemical industry, and the corrosion and cracking mechanism is more complicated. It is necessary to carry out innovative research on valve stem material and optimize the production process of coal chemical industry. , timely remove the hidden trouble of valve stem material corrosion and cracking failure in the process of coal chemical production.
Wudenalloy has focused on the production and manufacture of nickel alloys for more than 10 years. We are a principal worldwide supplier of corrosion-resistant alloys and other superalloy metals. We have a professional technical team and after-sales service, so we can offer high-quality Hastelloy, Incoloy, Inconel, Monel, Duplex Stainless Steel, and other alloy material. These materials are available in wire, bar, sheet&plate, pipe&tube, flange, forging, and other forms to meet the needs of our customers.
Request a quote now to get the competitive special alloy prices, you can also send emails to email@example.com, Wudenalloy is your trusted supplier of special alloy material.
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text:
Frazer Harrison/Getty Images
And the crown goes to...star of The Crown, Claire Foy!
Newcomer Foy just won best actress in a TV drama at the 2017 Golden Globes, and she sure seemed stunned.
"Oh my god, I'm having an out-of-body experience," she told the crowd as she took the stage to accept her award. "Thank you very very much, I'm so shocked. Thank you, Hollywood Foreign Press."
Foy plays Queen Elizabeth II in the Netflix series that chronicles her reign from the 1940s to present day, which means she's playing both a real and very recognizable public figure.
"When you play a real life person, it's tricky. And you rely very much on the people around you. So I'm going to dedicate this to all those people around me," Foy said, thanking her costars, directors, and Netflix.
"But big shoutout to John Lithgow," she added. Lithgow, who plays Winston Churchhill, was also nominated tonight.

domain: celebrity


text:
An animal model to evaluate the function and regulation of the adaptively evolving stress protein SEP53 in oesophageal bile damage responses.
ABSTRACT: Squamous epithelium in mammals has evolved an atypical stress response involving down-regulation of the classic HSP70 protein and induction of sets of proteins including one named SEP53. This atypical stress response might be due to the unusual environmental pressures placed on squamous tissue. In fact, SEP53 plays a role as an anti-apoptotic factor in response to DNA damage induced by deoxycholic acid stresses implicated in oesophageal reflux disease. SEP53 also has a genetic signature characteristic of an adaptively and rapidly evolving gene, and this observation has been used to imply a role for SEP53 in immunity. Physiological models of squamous tissue are required to further define the regulation and function of SEP53. We examined whether porcine squamous epithelium would be a good model to study SEP53, since this animal suffers from a bile-reflux disease in squamous oesophageal tissue. We have (1) cloned and sequenced the porcine SEP53 locus from porcine bacterial artificial chromosome genomic DNA, (2) confirmed the strikingly divergent nature of the C-terminal portion of the SEP53 gene amongst mammals, (3) discovered that a function of the conserved N-terminal domain of the gene is to maintain cytoplasmic localisation, and (4) examined SEP53 expression in normal and diseased porcine pars oesophagea. SEP53 expression in porcine tissue was relatively confined to gastric squamous epithelium, consistent with its expression in normal human squamous epithelium. Immunohistochemical staining for SEP53 protein in normal and damaged pars oesophagea demonstrated significant stabilisation of SEP53 protein in the injured tissue. These results suggest that porcine squamous epithelium would be a robust physiological model to examine the evolution and function of the SEP53 stress pathway in modulating stress-induced responses in squamous tissue.
Project description:As a major cellular defence mechanism, the Nrf2/Keap1 pathway regulates expression of genes involved in detoxification and stress response. Here we hypothesise that Nrf2 is involved in oesophageal barrier function and plays a protective role against gastro-oesophageal reflux disease (GERD).Human oesophageal biopsy samples, mouse surgical models and Nrf2(-/-) mice were used to assess the role of the Nrf2/Keap1 pathway in oesophageal barrier function. Trans-epithelial electrical resistance (TEER) was measured with mini-Ussing chambers. HE staining and transmission electron microscopy were used to examine tissue morphology, while gene microarray, immunohistochemistry, western blotting and chromatin immunoprecipitation (ChIP) analysis were used to assess gene expression.Nrf2 was expressed in normal oesophageal epithelium and activated in GERD of both humans and mice. Nrf2 deficiency and gastro-oesophageal reflux in mice, alone or in combination, reduced TEER and increased intercellular space in oesophageal epithelium. Nrf2 target genes and gene sets associated with oxidoreductase activity, mitochondrial biogenesis and energy production were downregulated in the oesophageal epithelium of Nrf2(-/-) mice. Consistent with the antioxidative function of Nrf2, a DNA oxidative damage marker (8OHdG) dramatically increased in oesophageal epithelial cells of Nrf2(-/-) mice compared with those of wild-type mice. Interestingly, ATP biogenesis, Cox IV (a mitochondrial protein) and Claudin 4 (Cldn4) expression were downregulated in the oesophageal epithelium of Nrf2(-/-) mice, suggesting that energy-dependent tight junction integrity was subject to Nrf2 regulation. ChIP analysis confirmed the binding of Nrf2 to Cldn4 promoter.Nrf2 deficiency impairs oesophageal barrier function through disrupting energy-dependent tight junction.
Project description:BACKGROUND: The oesophageal epithelium is exposed routinely to noxious agents in the environment, including gastric acid, thermal stress, and chemical toxins. These epithelial cells have presumably evolved effective protective mechanisms to withstand tissue damage and repair injured cells. Heat shock protein or stress protein responses play a central role in protecting distinct cell types from different types of injury. AIM: To determine (i) whether biochemical analysis of stress protein responses in pinch biopsy specimens from human oesophageal epithelium is feasible; (ii) whether undue stresses are imposed on cells by the act of sample collection, thus precluding analysis of stress responses; and (iii) if amenable to experimentation, the type of heat shock protein (Hsp) response that operates in the human oesophageal epithelium. METHODS: Tissue from the human oesophagus comprised predominantly of squamous epithelium was acquired within two hours of biopsy and subjected to an in vitro heat shock. Soluble tissue cell lysates derived from untreated or heat shocked samples were examined using denaturing polyacrylamide gel electrophoresis for changes in: (i) the pattern of general protein synthesis by labelling epithelial cells with 35S-methionine and (ii) the levels of soluble Hsp70 protein and related isoforms using immunochemical protein blots. RESULTS: A single pinch biopsy specimen is sufficient to extract and analyse specific sets of polypeptides in the oesophageal epithelium. After ex vivo heat shock, a classic inhibition of general protein synthesis is observed and correlates with the increased synthesis of two major proteins of molecular weight of 60 and 70 kDa. Notably, cells from unheated controls exhibit a "stressed" biochemical state 22 hours after incubation at 37 degrees C, as shown by inhibition of general protein synthesis and increased synthesis of the 70 kDa protein. These data indicate that only freshly acquired specimens are suitable for studying stress responses ex vivo. No evidence was found that the two heat induced polypeptides are previously identified Hsp70 isoforms. In fact, heat shock results in a reduction in the steady state concentrations of Hsp70 protein in the oesophageal epithelium. CONCLUSION: Systematic and highly controlled studies on protein biochemistry are possible on epithelial biopsy specimens from the human oesophagus. These technical innovations have permitted the discovery of a novel heat shock response operating in the oesophageal epithelium. Notably, two polypeptides were synthesised after heat shock that seem to differ from Hsp70 protein. In addition, the striking reduction in steady state concentrations of Hsp70 protein after heat shock suggests that oesophageal epithelium has evolved an atypical biochemical response to thermal stress.
Project description:Barrett's oesophagus is a precursor of oesophageal adenocarcinoma. In this common condition, squamous epithelium in the oesophagus is replaced by columnar epithelium in response to acid reflux. Barrett's oesophagus is highly heterogeneous and its relationships to normal tissues are unclear. Here we investigate the cellular complexity of Barrett's oesophagus and the upper gastrointestinal tract using RNA-sequencing of single cells from multiple biopsies from six patients with Barrett's oesophagus and two patients without oesophageal pathology. We find that cell populations in Barrett's oesophagus, marked by LEFTY1 and OLFM4, exhibit a profound transcriptional overlap with oesophageal submucosal gland cells, but not with gastric or duodenal cells. Additionally, SPINK4 and ITLN1 mark cells that precede morphologically identifiable goblet cells in colon and Barrett's oesophagus, potentially aiding the identification of metaplasia. Our findings reveal striking transcriptional relationships between normal tissue populations and cells in a premalignant condition, with implications for clinical practice.
Project description:The fundamental mechanisms underlying erosive oesophagitis and subsequent development of Barrett's oesophagus (BO) are poorly understood. Here, we investigated the contribution of specific components of the gastric refluxate on adhesion molecules involved in epithelial barrier maintenance. Cell line models of squamous epithelium (HET-1A) and BO (QH) were used to examine the effects of bile acids on cell adhesion to extracellular matrix proteins (Collagen, laminin, vitronectin, fibronectin) and expression of integrin ligands (?3 , ?4, ?5 , ?6 and ?? ). Experimental findings were validated in human explant oesophageal biopsies, a rat model of gastroesophageal reflux disease (GORD) and in patient tissue microarrays. The bile acid deoxycholic acid (DCA) specifically reduced adhesion of HET-1A cells to vitronectin and reduced cell-surface expression of integrin-?? via effects on endocytic recycling processes. Increased expression of integrin-?v was observed in ulcerated tissue in a rat model of GORD and in oesophagitis and Barrett's intestinal metaplasia patient tissue compared to normal squamous epithelium. Increased expression of integrin-?? was observed in QH BO cells compared to HET-1A cells. QH cells were resistant to DCA-mediated loss of adhesion and reduction in cell-surface expression of integrin-?? . We demonstrated that a specific component of the gastric refluxate, DCA, affects the epithelial barrier through modulation of integrin ?? expression, providing a novel mechanism for bile acid-mediated erosion of oesophageal squamous epithelium and promotion of BO. Strategies aimed at preventing bile acid-mediated erosion should be considered in the clinical management of patients with GORD.
Project description:About one-third of patients with suspected gastro-oesophageal reflux disease (GERD) do not respond symptomatically to proton pump inhibitors (PPIs). Many of these patients do not suffer from GERD, but may have underlying functional heartburn or atypical chest pain. Other causes of failure to respond to PPIs include inadequate acid suppression, non-acid reflux, oesophageal hypersensitivity, oesophageal dysmotility and psychological comorbidities. Functional oesophageal tests can exclude cardiac and structural causes, as well as help to confi rm or exclude GERD. The use of PPIs should only be continued in the presence of acid reflux or oesophageal hypersensitivity for acid reflux-related events that is proven on functional oesophageal tests.
Project description:BACKGROUND: The response of the oesophagus to refluxed gastric contents is likely to depend on intact neural mechanisms in the oesophageal mucosa. The epithelial innervation has not been systematically evaluated in health or reflux disease. AIMS: To study oesophageal epithelial innervation in controls, and also inflamed and non-inflamed mucosa in patients with reflux oesophagitis and healed oesophagitis. PATIENTS: Ten controls, nine patients with reflux oesophagitis, and five patients with healed oesophagitis. METHODS: Oesophageal epithelial biopsy specimens were obtained at endoscopy. The distribution of the neuronal marker protein gene product 9.5 (PGP), and the neuropeptides calcitonin gene related peptide (CGRP), neuropeptide Y (NPY), substance P (SP), and vasoactive intestinal peptide (VIP) were investigated by immunohistochemistry. Density of innervation was assessed by the proportion of papillae in each oesophageal epithelial biopsy specimen containing immunoreactive fibres (found in the subepithelium and epithelial papillae, but not penetrating the epithelium). RESULTS: The proportion of papillae positive for PGP immunoreactive nerve fibres was significantly increased in inflamed tissue when compared with controls, and non-inflamed and healed tissue. There was also a significant increase in VIP immunoreactive fibres within epithelial papillae. Other neuropeptides showed no proportional changes in inflammation. CONCLUSIONS: Epithelial biopsy specimens can be used to assess innervation in the oesophagus. The innervation of the oesophageal mucosa is not altered in non-inflamed tissue of patients with oesophagitis but alters in response to inflammation, where there is a selective increase (about three- to fourfold) in VIP containing nerves.
Project description:In several organ systems, the transitional zone between different types of epithelium is a hotspot for pre-neoplastic metaplasia and malignancy, but the cells of origin for these metaplastic epithelia and subsequent malignancies remain unknown. In the case of Barrett's oesophagus, intestinal metaplasia occurs at the gastro-oesophageal junction, where stratified squamous epithelium transitions into simple columnar cells. On the basis of a number of experimental models, several alternative cell types have been proposed as the source of this metaplasia but in all cases the evidence is inconclusive: no model completely mimics Barrett's oesophagus in terms of the presence of intestinal goblet cells. Here we describe a transitional columnar epithelium with distinct basal progenitor cells (p63+KRT5+KRT7+) at the squamous-columnar junction of the upper gastrointestinal tract in a mouse model. We use multiple models and lineage tracing strategies to show that this squamous-columnar junction basal cell population serves as a source of progenitors for the transitional epithelium. On ectopic expression of CDX2, these transitional basal progenitors differentiate into intestinal-like epithelium (including goblet cells) and thereby reproduce Barrett's metaplasia. A similar transitional columnar epithelium is present at the transitional zones of other mouse tissues (including the anorectal junction) as well as in the gastro-oesophageal junction in the human gut. Acid reflux-induced oesophagitis and the multilayered epithelium (believed to be a precursor of Barrett's oesophagus) are both characterized by the expansion of the transitional basal progenitor cells. Our findings reveal a previously unidentified transitional zone in the epithelium of the upper gastrointestinal tract and provide evidence that the p63+KRT5+KRT7+ basal cells in this zone are the cells of origin for multi-layered epithelium and Barrett's oesophagus.
Project description:Squamous cell carcinoma of the oesophagus is a common cancer among South Africans. Due to the absence of effective screening and surveillance programme for early detection and late presentation, squamous cell carcinoma of the oesophagus is usually diagnosed at an advanced stage or when metastasis has already occurred. The 5-year survival is often quoted at 5%-10%, which is poor.To determine the association between oesophageal squamous cell carcinoma (OSCC) and non-acid gastro-oesophageal reflux disease.Study design: A cross-sectional case-control analytical study of patients referred to the Gastroenterology Division of Steve Biko Academic Hospital in Pretoria, South Africa. All patients had combined multichannel impedance and pH studies done and interpreted after upper gastroscopy using the American College of Gastroenterology guidelines by two clinicians.Thirty-two patients with OSCC were recruited: non-acid reflux was found in 23 patients (73%), acid reflux in 2 patients (6%) and 7 patients (22%) had normal multichannel impedance and pH studies.Forty-nine patients matched by age, gender and race were recruited as a control group. Non-acid reflux was found in 11 patients (22%), acid reflux in 31 patients (63%) and 7 patients (14%) had normal multichannel impedance and pH monitoring study.The significance of the association between non-acid reflux and OSCC was tested using ?2, and simple logistic regression was used to adjust for the effects of potential confounders.The OR of developing OSCC in patients with non-acid gastro-oesophageal reflux was 8.8 (95% CI 3.2 to 24.5, P<0.0001) in this South African group.Alcohol and smoking had no effect on these results.
Project description:Patients with (previous) head and neck cancer (HNC) are at high risk for developing second squamous cell cancer of the oesophagus. The role of cyclooxygenase-2 (COX-2) in oesophageal squamous carcinogenesis has not yet been investigated in this high-risk group. Therefore, this study examined COX-2 mRNA and protein expression in oesophageal biopsies and resected tissues of 44 HNC patients. The evaluation covered 55 oesophageal tissue samples (18 invasive oesophageal squamous cell cancers, four high- and eight low-grade dysplasias, 25 normal squamous epithelia) from the 44 patients. mRNA levels of COX-2 were measured by real-time PCR using a LightCycler. COX-2 protein expression was studied immunohistochemically and graded by a staining score. COX-2 mRNA was detected in all samples, and its levels correlated positively with the immunohistochemical staining score (P<0.05). COX-2 expression was upregulated during oesophageal squamous carcinogenesis in HNC patients, that is COX-2 expression increased significantly from normal oesophageal squamous epithelium to low- and high-grade dysplasia and finally to invasive squamous cell cancer (P<0.001). Our findings suggest that COX-2 upregulation contributes to oesophageal squamous carcinogenesis in HNC patients. Prospective studies are needed to evaluate the chemopreventive potential of COX-2 inhibitors in this high-risk group.
Project description:Chronic inflammatory gastric reflux alters the esophageal microenvironment and induces metaplastic transformation of the epithelium, a precancerous condition termed Barrett's esophagus (BE). The microenvironmental niche, which includes the extracellular matrix (ECM), substantially influences cell phenotype. ECM harvested from normal porcine esophageal mucosa (eECM) was formulated as a mucoadhesive hydrogel, and shown to largely retain basement membrane and matrix-cell adhesion proteins. Dogs with BE were treated orally with eECM hydrogel and omeprazole (n = 6) or omeprazole alone (n = 2) for 30 days. eECM treatment resolved esophagitis, reverted metaplasia to a normal, squamous epithelium in four of six animals, and downregulated the pro-inflammatory tumor necrosis factor-?+ cell infiltrate compared to control animals. The metaplastic tissue in control animals (n = 2) did not regress. The results suggest that in vivo alteration of the microenvironment with a site-appropriate, mucoadhesive ECM hydrogel can mitigate the inflammatory and metaplastic response in a dog model of BE.


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Adrian Barber looks at enhancing the function of Building Energy Management Systems by targeting the control of heating in student accommodation on a room-by-room basis with pin-point accuracy.
Providers of large-scale multi-occupancy dwellings have had a rude awakening over the last 12 months regarding their business model. By this I mean what they include in their rental contract. To attract tenants, big beds, TVs, high-speed Wi-Fi, etc. are all good add-ons, but many also include cost of heating rooms and water. This is where the stranglehold is tightening. With little supervision over the amount of energy being consumed in each room, providers are faced with rising energy bills beyond their control.
The cost-of-living crisis has already had a significant impact on one part of this sector – student accommodation. Last year’s National Student Accommodation Survey quoted 53% of students already struggling with the cost of rent while 79% are worried about rising bills. Around 60% of students have energy bills included in their rent. This represents a significant number of people that are using more expensive energy but are not directly responsible for paying the bills. Landlords will find it difficult to increase rents to cover this shortfall.
In our line of work, we witness a broad scope of heating ‘solutions’ in student rooms. Antiquated storage heaters, ‘wet’ radiators, electric panel heaters and air-conditioning units to name a few. We see a variety of ‘control’ methods which all include some variation on the theme of a thermostat, in most cases the domestic type we are all familiar with.
The issue with these is precisely that, we are all familiar with them. They may have built in programmers and timers and perhaps a rudimentary lock to keep children from fiddling with them, but this is very easy to circumnavigate. Once unlocked it can be set to maximum and is then forgotten about. In most cases the preferred method of temperature control is to open and close the window!
In some cases, a Building Management System (BMS) or Building Energy Management System (BEMS) has been installed to automate control. By focussing on energy management BEMS provide metering, sub-metering and monitoring functions which collate data from around a site. This gives Energy Managers detailed insight of a site’s usage which is invaluable in programming systems and equipment for optimum efficiency. BEMS will oversee and control the entire site, switch boilers, manage blocks of rooms and heat water efficiently. But BEMS are a blunt instrument when it comes to individual room control as they are unable to communicate directly with and control an individual room’s thermostat.
Using a traditional thermostat’s programming capability will help save energy – timed events for example will switch the heater on between 9am & 11am, then again between 5pm-9pm. This provides a modicum of control. But if we can pin-point energy use to a room-by-room level and stop waste with a system that controls consumption at individual points of use, in real time, then this is where all the small savings really begin to add up.
Rooms must be comfortable, but in these energy conscious times there is no sense in keeping them hot when nobody is in them or continuing to pump heat in if windows or doors are opened. These intricacies are not possible with BEMS, but with intelligent thermostats that detect absence and recognise sudden temperature drops Energy Managers can be confident that their energy budget is being used wisely.


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What is up, all of my lovely peeps!? I’m taking a minute today to write about something that I don’t talk about a lot. (On purpose) And that thing is…. drumroll… being Vegan. Ugh, welp, that’s out there. In the interest of full disclosure, I have to say right off the bat that I am what I call “dirty vegan”. Many people have difficulty distinguishing the difference between “vegan” and “vegetarian”. Here’s the diff. Vegetarian = No meat. Vegan = No animal products at all, whatsoever. This includes dairy. The term “dirty vegan” refers to someone who is vegan most of the time, but will occasionally make an exception with eggs or dairy. I prepare all of my food at home completely vegan. The recipes I post here are 100% vegan. However, if I go out to eat and there is butter in something, I’m not going to throw a hissy fit. Because, well… you just can’t always do that. And let me also state that if I find myself on a farm, where I see the farmer gently collecting milk and see the chickens roaming free and sitting on their nests, I have ZERO problem with consuming the eggs and milk that comes from this, but most of you probably (at least slightly) know… that’s not what happens before these things hit the shelf at your local grocery store. I have had people say to me, “I’m vegetarian, too! I don’t eat any red meat, but I still eat chicken and fish.” At the risk of sounding condescending… PEOPLE! STOP! PLEASE! Look up “vegetarian” in the dictionary because I’m pretty sure chicken and fish are still meat. Like, that’s not even a gray area. The term “pescatarian” actually refers to someone who does not eat other meats, but still eats fish. There is your Biology 101 lesson for the day. Anyway… I digress… Read more
I absolutely love cooking for family and friends during the Holidays! But when you have a strict “no animal products” policy when it comes to your diet, it can be difficult to make a Holiday dinner that will be enjoyed by not just you, but loved by all. The next time you find yourself in this difficult scenerio, try my veggie lasagna recipe. My family loved it… and I hope yours will, too! 😋🍴
2 packages of Daiya cheese in flavors of your choice
1 onion, chopped
1 small head of garlic, all cloves chopped or pressed
8 oz mushrooms, sliced
1 head broccoli, chopped
2 carrots, chopped
2 red bell peppers, seeded and chopped
1/2 tsp cayenne pepper
1 tsp oregano
1 tsp basil
1 tsp rosemary
2 jars pasta sauce
2 boxes whole grain lasagna noodles
16 oz frozen spinach, thawed and drained
Note: to save time with the spices, I often just use Mrs. Dash Italian or Extra Spicy Seasoning Blend. It already has most of the spices you will need for this recipe and they are already blended together perfectly. For this recipe, I used a little over a tabllespoon of the Extra Spicy blend and nixed the cayenne as well. It worked out PERFECTLY!
Preheat oven to 400 ° F. Saute the onion and garlic on high heat for 3 minutes in a wok or nonstick pan. Add the mushrooms and cook until the onions are limp and the mushrooms give up their liquid. Remove them to a large bowl with a slotted spoon. Reserve the mushroom liquid in the pan. Saute the broccoli and carrots for 5 minutes and add to the mushroom bowl. Saute the peppers until just beginning to soften. Add them to them to the vegetable bowl. Add spices to the vegetable bowl and combine.
Cover the bottom of a 9×13 inch casserole with a layer of sauce. Add a layer of noodles. Cover the noodles with sauce. This way the noodles cook in the oven, saving time and energy. Spread the vegetable mixture over the sauced noodles, and add about half of the cheese. Cover with a layer of noodles and another dressing of sauce. Add the spinach to the second layer of sauced noodles. Add another layer of sauce, the final layer of noodles, and a last topping of sauce. Cover the lasagna with the remaning cheese. Cover with foil and bake in the oven for 45 minutes. Remove the foil and let sit for 15 minutes before serving.
Did you know May 18th is “National I Love Reece’s Day“? Yep! My two favorite things, chocolate and peanut butter combined and a day to celebrate! Happy “National I Love Reece’s Day” folks! If you’re looking for a way to celebrate, check out my simple how to video to make my new favorite (vegan) dessert.
1 box brownie mix
Egg replacement for 2 eggs
Earth balance or other oil based butter (melted to a half cup)
Well, I don’t know about everyone else… But I’m starting to feel like winter is NEVERRRR going to be over! We are experiencing teases of spring one day and arctic blasts the next. If you’re like me and you need some comfort food to spice you up on those below zero days, try this recipe! You can make this as a casserole, use it as a dip with chips, or you can roll it up as traditional enchiladas… whichever you prefer. I may or may not have eaten mine straight out of the dish… 😉 MMM MMM Delish!!
1 cup quinoa
1 can (10-ounce) enchilada sauce
1 can (4.5 ounce) chopped green chilies, drained
1/2 cup canned corn kernels, drained
1/2 cup canned black beans, drained and rinsed
2 tablespoons chopped fresh cilantro leaves
1/2 teaspoon cumin
1/2 teaspoon chili powder
3/4 cup shredded Daiya (vegan) or regular cheddar cheese, divided
3/4 cup shredded Diaya (vegan) or regular mozzarella cheese, divided
1 avocado, halved, seeded, peeled and diced
1 Roma tomato, diced
Salt & pepper to taste
In a large saucepan of 2 cups water, cook quinoa according to package instructions and set aside.
Preheat oven to 375 degrees F.
Lightly oil an 8×8 or 2 quart baking dish or coat with nonstick spray
In a large bowl, combine quinoa, enchilada sauce, green chilies, corn, black beans, cilantro, cumin and chili powder. Season with salt and pepper to taste.
Stir in 1/2 cup cheddar cheese and 1/2 cup mozzarella cheese.
Spread quinoa mixture into the prepared baking dish.
Top with remaining cheeses.
Place in oven and bake until bubbly and cheeses have melted. (About 15 minutes)
Serve immediately, garnished with avocado and tomato, if desired.
Stuffed peppers seems to be a recipe that tends to get passed down from generation to generation. If you’re an odd ball like me, no one in your family ever made the dish and you need a simple starter recipe. Here’s a mouth-watering stuffed pepper recipe that contains absolutely zero animal products and will leave you full and satisfied! It takes a little bit longer than most of the recipes I share with you, but trust me when I say it is worth it!! Read more
Does anyone have a case of the “Mondays”? Want a quick and easy way to liven up the dinner table this Meatless Monday? You’re in for a treat! I’m officially sharing with you my signature Chick’nless Parmesan dish, my absolute favorite of my cruelty free recipes and my personal “go-to” when I need something quick, easy and delicious to prepare for dinner guests. If you’re looking for a healthy dish free of animal products that tastes like the “real” thing, this one’s for you. Read more
We’ve heard of Portobello mushroom burgers, and we’ve heard of Eggplant Parmesan… but have you ever heard of Portobello Parmesan? Furthermore, what about putting in on a burger? This is where experimentation lands you. After scouring my pantry and refrigerator one night and only finding a hodgepodge of ingredients, I knew I would have to get creative. This deliciously light recipe is perfect for Summer. You can make the Portobello Parmesan alone, or stick it on a burger and pair it with fries like I did. Read on for the recipe. Read more
The most common and probably the most frustrating question I am asked when I tell people that I’m a vegan is, “Don’t you get tired of eating salads?” OHHH EMMM GEEE, PEOPLE!! I don’t even LIKE salad! Trust me when I say I do not starve, eat dainty, or feel deprived in any way. In fact, thanks to products like Gardein, I don’t even miss meat. These meat substitute options are quick, delicious, and most of them only take about 8 minutes to make! Continue reading for a few of my favorite Gardein meals to put on the table this “Meatless Monday”!! 🙂 Read more
Most of us can identify with this familiar scenario: After a long day at work, we’re then faced with the daily challenge of deciding what to rustle up for dinner! Often times we opt for the fast food drive through or settle for whoever delivers. Options that are detrimental to our health. Let’s give the pizza delivery boy a break tonight, shall we? If you’re on the hunt to put something delicious and healthy on the table tonight, this zesty mouth-watering dish is sure to brighten your case of the “Mondays”. Does anyone NOT like Mexican food? To that end… who doesn’t like casserole? I aim to please. You have got to try this delicious and filling Mexican Casserole Recipe. And guess what? IT’S VEGAN!! 🙂 Read more

domain: food


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Single baroque pearls anchor simple golden bars on these linear drop earrings that will surely be your favorite pair!
Biwa and petite pearls dangle from a gold filled exaggerated hook and chain
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domain: design


The second episode of My So-Called Life didn’t feel like the second episode of a new series. Maybe because the first episode did such a good job at setting up Angela Chase’s world, by episode two the viewer already feels pretty settled in, and invested in the characters.
The second episode picks up shortly after the upbeat ending of the first episode. Of course, contentment is boring to watch, so soon after the opening credits roll, we see more of the conflict between Angela’s parents, who have hit a rut in their marriage, and we see a side Angela we don’t really like when it becomes clear that she’s taking advantage of her brainy lab partner, Brian.
What’s interesting about Angela is that she’s a pretty good “everyteen” that viewers can relate to. But unlike supposed modern-day everyteens (paging Bella Swan), Angela is an interesting, dynamic character. Despite her fairly shy exterior, she is not a weak character. In the premiere, we saw Angela, for the first time in her young life, making the decision to be “bad.” But instead of being punished, she is rewarded for these decisions. This is unusual, especially for a female character.
Choosing to go to a bar with Rayanne, to lie to her parents, and to do something that she knows could be dangerous, leads Angela to bond with her new friends, impress her crush when he sees her get put into a cop car, and then charm the police officer to the point that he doesn’t turn her in to her parents.
Not to mention, Angela is not nearly as timid as she appears. Last week, her first conversation with Jordan Catalano, the awkward, stilted moments of which made him aware of her in the first place, was due to the fact that she approached him. That’s the entire reason he was able to recognize her when she got into the cop car.
This week, Rayanne orchestrates an interaction between Angela and Jordan Catalano by asking Jordan if he can get Angela a fake ID. When she heads over to Brian’s house to work on their science project, Rayanne brings Jordan over, and he waits in his car for Angela to come outside. Angela dawdles in the house before coming out, peeking at Jordan through the curtains and telling Rayanne that maybe the fantasy of someone you have a crush on is worth protecting. It’s almost as if she’s anticipating the unpleasant experience to come after she gets in his car.
Basically, when Jordan feels a spark or sexual tension with a girl, his M.O is to sloppily make out with her. When he tries this with Angela, she pushes him off and chastises him for not “working up to that.” I was once again proud of our girl for being assertive with Jordan, and it’s clear that she made an impression on him. He, like most good-looking guys in high school, probably hadn’t been turned down before. His initial negative reaction is betrayed by the fact that he drives by again, pretending to be looking for Tino.
The episode ends with another strong moment between Angela and her dad. After an episode-long discussion on their inability to connect, and Graham’s horrible comment that Patty’s new haircut “shows her ears more,” Angela’s parents seem to tentatively make up. Add in some leftover spaghetti bonding time with Angela, and it seems like this episode has another happy ending. But when Angela heads back downstairs, she overhears her dad (who doesn’t yet have the option of a cell phone, poor guy) break it off with his mistress. For the second time in one night, she’s learned that the men in her life she’s put on a pedestal may not be perfect after all.
I’ve been reminded that TV shows didn’t always preview the highlights from next week’s episode as the credits roll. So we’ll just have to wait until next week to see what happens next. My guess is Jordan Catalano will lean against some things and close his eyes.
2 replies on “Ladyghosts: My So-Called Life, Episode 2”
I just started watching this show again recently on Hulu. I always had fond memories of it, and now I remember why. It’s so rare to find stories about teenagers and high school life that gives the characters such depth, instead of compartmentalizing them into convenient stereotypes like “jock,” “cheerleader,” and “nerd.”
I know! This show really holds up. My cynical, older self finds some of Angela’s quotes and mini-speeches to be overly earnest, but it still is a remarkably realistic portrayal of teenage life. (And I’m watiching on Hulu too! I’m a cheap SOB. I’ll get the DVD someday)


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Starring: Carlos Alazraqui, Daran Norris, Susanne Blakeslee, Tara Strong
Genres: Animated, Comedy, Family, Fantasy
The Big Problem! / Power Mad! - S1-E1
Trivia: In the episode "Power Mad", when Timmy, Chester, and AJ enter the video game, their outfits are almost identical to the virtual outfits in the movie "Tron".
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Wanda: Awwwww, Goat Love.Cosmo: They say it's the most honest love around.
In the movie "Channel Chasers," when Timmy and Vicky go into Maho Mushi, Timmy gets a piece of his hat sliced off and Vicky gets the tip of her ponytail sliced off. But in the next shot, they're both back to normal.

domain: entertainment


Ontario court strikes down anti-prostitution laws
An Ontario court has struck down several key provisions in Canada's anti-prostitution laws, saying they are dangerous to sex-trade workers.
A ruling by the Ontario Superior Court of Justice said the laws against keeping a common bawdy house, communicating for the purposes of prostitution and living on the avails of the trade "are not in accord with the principles of fundamental justice."
"These laws, individually and together, force prostitutes to choose between their liberty interest and their right to security of the person as protected under the Canadian Charter of Rights and Freedoms," Justice Susan Himel wrote her in 131-page decision, which struck down those provisions.
"I find that the danger faced by prostitutes greatly outweighs any harm which may be faced by the public."
Dominatrix Terri-Jean Bedford and two other sex-trade workers went to Ontario's Superior Court of Justice to ask the court to rule on the Criminal Code laws relating to prostitution.
In an afternoon press conference Bedford said Tuesday was like emancipation day for sex-trade workers.
"It's important that women have safety and security in this business," Bedford said later Tuesday on CTV's Power Play. "It is legal, and like with any other legal business in Canada there are health and safety laws that go along with it."
Prostitution is not illegal in Canada, but nearly everything related to it is.
The struck-down provisions deal with adult prostitution. Prostitution laws dealing with those under the age of 18 remain unaffected.
Lawyer Alan Young, who represented the women, said the ruling "means the sex trade is changing in Canada."
"Whether Canadians like prostitution and think it's morally valuable or a moral vice really is not important," Young told Power Play. "This was a safety issue to ensure that people who are legally allowed to sell sex can do it in an environment that doesn't put them in harm's way."
Young said the case was based on the fact that the provisions the court struck down compromised the safety of sex workers. For instance, the prohibition on communicating for the purpose of prostitution prevented sex workers from screening their clients, while the provision against operating a bawdy house prevented them from moving their business off the streets, where it is more dangerous.
In her ruling, Himel said Parliament had to "fashion corrective action" to put new laws in place.
"It is my view that in the meantime these unconstitutional provisions should be of no force and effect, particularly given the seriousness of the charter violations," Himel wrote.
"However, I also recognize that a consequence of this decision may be that unlicensed brothels may be operated, and in a way that may not be in the public interest."
The Christian Legal Fellowship, which was granted intervenor status, argued that prostitution "offends the conscience of ordinary Canadians."
The government argued removing the prohibitions without replacing them with new laws would "pose a danger to the public."
The decision is subjected to a 30-day stay and the federal government can seek an extension of that period.
The federal government has previously argued that prostitution is inherently dangerous, no matter where it is carried out.
It has also argued that striking down the laws would make Canada a sex tourism destination.
Rona Ambrose, the minister of state for the status of women, told reporters Tuesday the government is "concerned with the decision and we are seriously considering appealing it at this time."
Deputy NDP Leader Libby Davies said Tuesday's ruling "breaks down the myth that these laws were actually protecting sex workers and local communities, because not only were they not protecting sex workers, they were actually harmful."
Davies said she has often heard from her constituents in Vancouver's downtown eastside who say the provisions prevented them from reporting violence or exploitation.
"We need to distinguish between what is consenting between two adults and what is exploitative, coercive and violent and focus the law-enforcement on those aspects," Davies said.
With files from The Canadian Press


Nissan has delivered the vehicles that became Madrid and Barcelona’s first 100-percent electric taxis.
These first Spanish EV taxis are a Nissan Leaf for Madrid’s taxi fleet and a e-NV200 taxi for Barcelona.
Nissan stated the Barcelona deliveries served as an important step in the execution of an agreement between Nissan, the City of Barcelona, and the Barcelona Metropolitan area which brings the Barcelona-built e-NV200 to the streets of the city where the revolutionary electric van is produced.
“Declining air quality levels are a top concern across Europe and it’s great to see Madrid and Barcelona taking such positive steps in improving air quality through the incorporate of Nissan’s all-electric cars into their taxi fleets,” said Jean-Pierre Diernaz, Director of Electric Vehicles for Nissan Europe. “These taxi bring a huge benefit not only residents but also for the drivers – thanks to the ultra-low running costs only an electric car can offer. This scheme demonstrates that sustainable transportation is easy and affordable for everyone.”
An event was held at Puerta del Sol in Madrid, where the “Zero KM” the measuring starting point of all the Spanish roads is located, to celebrate the arrival of this first Leaf taxi.
Antonio Berzal Prieto is the first taxi driver in Madrid to choose electric technology for his business.
“When I heard that the Nissan LEAF had been approved as a taxi for the city, I quickly looked into all the options it offered me,” said Antonio Berzal Prieto. “In addition to the environmental benefits, the costs of ownership are highly competitive and the car’s performance is excellent.”
Meanwhile in Barcelona, the delivery of the first three Nissan e-NV200 Taxis took place during the Expo-electric Formula-e event, described by Nissan as one of the most important meetings on sustainable mobility in Europe. Marco Toro, Nissan Iberia Managing Director and Antoni Vives, Deputy Mayor for Urban Habitat at Barcelona City Council, attended the event.
These first three e-NV200 Taxis units are, according to Nissan, part of the Memorandum of Understanding signed last year between Nissan, the Barcelona City Council and the Barcelona Metropolitan Area, which set out a number of different and significant measures to promote and to sustain the rollout of sustainable mobility in Catalonia Region.
The e-NV200 began production in Barcelona in May, with the Catalan city building the electric commercial vehicle for the global market.


Reply To: A gun fan from china!
“XFGun”… I love it! And spelling “калибр” with an N and what looks like a lambda and a 6. The Forgotten Weapons channel on YouTube has a couple videos about early 20th Century Chinese and more recent Afghan knockoff firearms. The markings on some of them are bizarre and hilarious. Glad to see Chinese airgunners are keeping the tradition alive.


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Trump authorizes new sanctions against foreigners who meddle in US elections
President Donald Trump has signed an executive order that will slap sanctions on foreign companies or people who interfere in US elections.
The sanctions will target anyone attacking election infrastructure or distributing propaganda or misinformation, national security adviser John Bolton claimed. The order, Bolton said, will “protect the United States from foreign interference in our elections and really our political process more broadly.”
The order will allow the Director of National Intelligence to identify parties “acting as an agent of or on behalf of a foreign government” with the “intent or purpose of interfering” in elections, and direct the Treasury Department to apply sanctions. In making that assessment, the DNI will consult with all of the US’ multifarious intelligence agencies.
Potential sanctions could include a block on financial transactions, export license restrictions, restrictions on access to American financial institutions and investments, and restrictions on entry to the US.
“I don’t even understand how you would even apply this,” legal and media analyst Lionel told RT.
The order is so ambiguous that it might be impossible to implement, Lionel said, adding that a proper legal statute would define the terms it applied to, but this executive order does not.
“Propaganda is in the eye of the beholder,” Lionel told RT. “If I say something that you absolutely disagree with… is that disinformation? Is that propaganda?”
While not strictly specified, the order more than likely targets Russia. White House Special Counsel Robert Mueller has indicted 13 Russian individuals and three companies for allegedly meddling in the 2016 presidential election. These so-called ‘Russian hackers’ supposedly purchased Facebook advertisements in an attempt to sway debate, but even Deputy Attorney General Rod Rosenstein admitted that no proof exists that the final election result was actually influenced.
Director of National Intelligence Dan Coats told reporters on Wednesday that the US is not currently seeing a Russian interference campaign, but warned that “it’s only a keyboard click away.” Coats did not tell reporters what evidence, if any, the intelligence community has seen of Russian hacking this year, but mentioned that he had seen “capability and attempts” from Iran, China, and North Korea as well.
Trump’s order comes less than 100 days before American voters head to the polls for the midterm elections, and just two months after Trump was derided by both Democrats and Republicans for declining to press Russian President Vladimir Putin harder on Russia’s alleged election meddling, after the pair met in Helsinki.
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Male City Council temporarily halted issuing of construction permits on Sunday, after a young girl was left in critical condition when a bag of cement fell on top of her at a construction site.
Speaking at a press conference, Male City Council's Mayor Shifa Mohamed stated that the council had had meetings planned with construction firms at the time of the incident.
She stated that the council has decided to withhold construction permits over the accident, and shared that the council has so far noted several safety issues at construction sites in the capital.
The mayor assured that the council will discuss safety concerns with construction firms and come up with the necessary solutions.
Shifa added that Male City Council will resume issuing construction permits after the meetings.


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Worried savers flock to building societies
Building societies saw deposits hit record highs over September as savers flocked to them following the Northern Rock crisis.
Their net receipts almost doubled over September in comparison to the year before, shooting up 181% to £2.8bn.
This was more than double the amount deposited in August, nearly three times the amount deposited in September last year and nearly £1bn higher than the previous record.
The previous record had occurred when unsuccessful applicants for TSB shares redeposited £1.9bn of their money in building societies in October 1986.
Savings accounts and cash Isas were the main beneficiaries - the latter up almost a fifth to £68m over the month - as anxious investors pulled their savings from Northern Rock and went looking for more secure investments elsewhere, according to the Building Societies Association (BSA).
Up to £7bn is believed to have been withdrawn from Northern Rock, with National Savings & Investments products and banks such as Bradford & Bingley proving popular alongside building societies.
Unlike the Bank of England, which has been criticised for not acting on the impending credit crisis, building societies claim to have been implementing strategy early, reining in their loan approvals over the past 12 months and only lending to those members which they believed could afford to borrow.
Their gross advances – the total value of residential mortgage loans advanced by societies - in September were down 16% to £4.2bn.
However the decrease in advances did not just take place in September but has been on-going over the past 12 months, according to Neil Johnson, policy manager for the BSA.
He said: 'Building societies have always undertaken less fiscal lending but over the past year, as economic conditions have worsened, they have tightened their lending practices.'
Northern Rock: Readers' advice and discussions
Don't miss our latest advice on Northern Rock and tips from our readers...
Adrian Coles, director-general of the BSA, added: 'It is likely that a significant proportion of the inflow is due to withdrawals from Northern Rock bank being redeposited in building societies. With savers searching for the best home for their money, the wide range of attractive savings products that societies offer proved to be very competitive.'
On the mortgage figures, he said: 'It is clear that the impact of higher interest rates is continuing to dampen the housing market, and societies are continuing to ensure that they are lending only to those who can afford to borrow. These factors meant that lending in September was subdued compared to last year. Despite this, net lending and approvals were up from the previous two months.'
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Milwaukee-based Rockwell Automation Inc. plans to consolidate distribution operations in Illinois and Tennessee into a new distribution center in Indianapolis, according to the company.
The closures involve a distribution center and customer-returns centers in Champaign, Illinois, that employ more than 200 people. Bruce Quinn, a spokesman for Rockwell, told the News-Gazette of Champaign that the closures would take place in about a year.
The other closure involves a distribution center in Memphis with an undisclosed number of employees.
Quinn said the employees at the facilities will have the opportunity to apply for similar jobs at the Indianapolis location.
The Indianapolis plant will use automation to improve operations, the company said, and will be managed by Kuehne + Nagel, a global logistics company headquartered in Switzerland.
Quinn said the change is "part of optimizing what we do and how we do it."

domain: economics


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Earlier today we heard about the new software update for Pokemon GO that will bring real world weather to the game.
The developers of the game have now released a video for the update, which you can see below, the update also brings a range of other new features to the game.
You’ll want to start paying even closer attention to your local weather patterns, Trainers. In addition to the in-game map being updated with cool new weather visuals, weather near you will impact Pokémon in a variety of ways. For example, you’ll find your odds of discovering Mudkip splashing around will greatly improve on rainy days, as certain Pokémon types will be more commonly found during various weather conditions. Additionally, attacks of certain types will be more effective during some weather conditions, so a Charizard’s Fire Spin will perform better on sunny days, for example. Rain or shine, winter or spring, your gameplay experience will remain fresh, making your time outdoors even more exciting.
You can find out more details about the latest version of Pokemon Go over at the game’s website at the link below.
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Ever find yourself clicking away at your MacBook or sifting through the latest sample sale only to find yourself humming along to that catchy tune for the umpteenth time? No doubt, summer's the season for earworm songs — just ask Carly Rae Jepsen or Gotye, who are still dominating the charts. Here at R29, we've rounded up the catchiest, can't-get-out-of-your-head tunes from our sunny city's best bands. Listen up and learn why we don't mind having these tracks on constant repeat — just don't blame us if they stick to your brain like glue, too!
"Lovely Cup" by Grouplove
Recognize these folks from Glee? Sure, their chart-topping hit "Tongue Tied" was featured on the primetime TV show, but that's not all they're known for: The band has also gained serious success with the debut album, Never Trust a Happy Song. This L.A. indie rock band continuously churns out super-infectious tunes like "Lovely Cup," which have smooth bass lines, sweet guitar licks, and the sort of repetitious lyrics that were born for the sole purpose of burrowing deep into your mind.