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We, and others, have shown that the negative T cell costimulatory pathways play a critical role in regulating alloimmune responses and tolerance. Our overall hypothesis is that the integration of positive and negative signals delivered by allogeneic hematopoietic and/or parenchymal cells under inflammatory conditions dictates tolerance vs tissue destruction. Our main goal is to define the relationship between these signals at the tissue level and outcome of alloantigen exposure during graft-vs-host disease (GVHD) and organ grafting models. Lessons learned from these distinct but interrelated and complementary models will further our understanding of the mechanisms of GVHD and organ allograft rejection and tolerance. These studies will lead to development of novel therapeutic strategies by harnessing the physiologic mechanisms that regulate immune responses. We propose to address three questions: 1) What is the role of hematopoietic vs parenchyma cell expression of negative costimulatory molecules in alloimmunity and tolerance? 2) What are the important and unique interactions between positive and negative costimulatory pathways that determine the fate of alloimmune response in an inflammatory environment? 3) What are the effects and mechanisms of targeting of these pathways in preclinical models of alloimmune responses? Our specific aims are:
AIM 1 : To investigate the functions of the PD-1:PD-L1,-L2 negative costimulatory pathway in GVHD and solid organ transplants. 1A. Study the role of the PD-1 pathway in GVHD focusing on the parenchymal vs hematopoietic cell expression of PD-1 ligands in regulating alloimmunity. 1B. Study the role of PD-1 pathway interactions with the CD28/B7 positive T cell costimulatory pathway that augments and donor Tregs that suppress GVHD. 1C: To investigate the functions and mechanisms of PD-1:PD-L1 and B7-1/PD-L1 interactions in alloimmune responses in models of solid organ transplantation.
AIM 2 : To investigate the functions of B7-H3 expression on hematopoietic vs parenchymal cells during GVHD (2A). In order to define the exact functions of this novel pathway in alloimmunity we plan to characterize the B7-H3 receptor, TLT2, and clone a putative second and inhibitory B7-H3 receptor (2B). We have a number of unique tools that will enable us to dissect the functions, mechanisms, and interactions of negative and positive costimulatory pathways and the microenvironment that will permit the optimal targeting of costimulatory pathways to inhibit detrimental T cell alloresponses that limit hematopoietic and solid organ allograft acceptance.
The results of our studies should have major implications for the understanding of the physiologic pathways that regulate alloimmune responses and provide the rationale to develop novel therapeutic strategies to prevent and treat GHVD, and induce tolerance in solid organ and cell transplantation.
|Flynn, Ryan; Du, Jing; Veenstra, Rachelle G et al. (2014) Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans. Blood 123:3988-98|
|Penaloza-MacMaster, Pablo; Kamphorst, Alice O; Wieland, Andreas et al. (2014) Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection. J Exp Med 211:1905-18|
|Sawitzki, Birgit; Brunstein, Claudio; Meisel, Christian et al. (2014) Prevention of graft-versus-host disease by adoptive T regulatory therapy is associated with active repression of peripheral blood Toll-like receptor 5 mRNA expression. Biol Blood Marrow Transplant 20:173-82|
|Dubovsky, Jason A; Flynn, Ryan; Du, Jing et al. (2014) Ibrutinib treatment ameliorates murine chronic graft-versus-host disease. J Clin Invest 124:4867-76|
|Xiao, Yanping; Yu, Sanhong; Zhu, Baogong et al. (2014) RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance. J Exp Med 211:943-59|
|Porichis, Filippos; Hart, Meghan G; Zupkosky, Jennifer et al. (2014) Differential impact of PD-1 and/or interleukin-10 blockade on HIV-1-specific CD4 T cell and antigen-presenting cell functions. J Virol 88:2508-18|
|Mott, Kevin R; Allen, Sariah J; Zandian, Mandana et al. (2014) Inclusion of CD80 in HSV targets the recombinant virus to PD-L1 on DCs and allows productive infection and robust immune responses. PLoS One 9:e87617|
|Joller, Nicole; Lozano, Ester; Burkett, Patrick R et al. (2014) Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses. Immunity 40:569-81|
|Alexander, Kylie A; Flynn, Ryan; Lineburg, Katie E et al. (2014) CSF-1-dependant donor-derived macrophages mediate chronic graft-versus-host disease. J Clin Invest 124:4266-80|
|Ding, Zhi-Chun; Lu, Xiaoyun; Yu, Miao et al. (2014) Immunosuppressive myeloid cells induced by chemotherapy attenuate antitumor CD4+ T-cell responses through the PD-1-PD-L1 axis. Cancer Res 74:3441-53|
Showing the most recent 10 out of 152 publications


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Mohawk’s men’s volleyball team lost 3-1 to Humber in the championship match of the Durham Cup Invitational Tournament in Oshawa on Saturday (Oct. 22).
The men’s won their first two matches at the Durham Cup Invitational Tournament in Oshawa Friday (Oct. 21). The Mountaineers downed Loyalist 3-0 (25-19, 25-20, 25-23). Phil Youngblut had 11 kills, two blocks and one ace. Moe Sulaiman collected nine kills one block and one ace and Ryan De La Rosa contributed 11 digs.
Mohawk then defeated Seneca 3-1 (21-25, 25-18, 25-20, 25-23). Justoin Scapinello led the way with 18 kills, one block and three aces. Sulaiman had 14 kills, one block and one ace and Mark Kaveckas had 44 assists.
Earlier on Saturday, Mountaineers earned their berth in the championship match by sweeping Trent, 25-21-25-20, 25-14. Ross had eight kills, one block and one ace. Derek Levesque contributed four kills, two blocks, one ace and seven digs for the Mountaineers, who played all their rookies in this match, some seeing their first action of the year.
In the championship match, the men met their match against Humber losing 3-1; the scores were 25-19, 21-25, 17-25, 21-25. Justin Scapinello had 18 kills, one stuff block and one service ace for the Mountaineers. Mo Sulaiman had 18 kills, one block and one ace.
Mohawk head coach Matt Schnarr said Andrew Ross came off the bench and passed the ball very well. Both Scapinello and Ross were named to the tourney All-Star Team.
Coach Schnarr said Humber is a very experienced side. His team played very well, but there are still some things to work on.

domain: game


Southern University Shreveport Student Center
Because the needs of the student population at Southern University Shreveport had outgrown their student union facility, KSA was secured to design improvements. The project involved the renovation and expansion of the student center area that serves as something of a gateway to the campus. The existing student center was renovated into a bookstore, meeting room and 7,800 square feet of office space. 8,500 square feet of new construction was added to make-up a dining and serving area, food preparation space and a student life area. The space was enhanced with stained concrete floors, ceramic tile, large, trapezoid steel framed accent structures mounted at the building’s support columns and aluminum storefront walls.
The student activity center also serves as an expanded food court for the campus. The dining area has a food court concept with two vendors. It was planned for 250 students and includes an outdoor dining area large enough to accommodate 100 additional bodies. This outdoor space overlooks the center of campus and provides the ideal mingling area for students. The student center is located near the middle of campus on a main pedestrian path that leads to the student parking lot. Its exterior used new materials to blend with the existing campus design, while also providing alluring, colorful elements. The changes made to the campus gave it an open, active and inviting character.


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A few days before April 1, Volkswagen released an official release about the upcoming rebranding: supposedly in the United States, the brand will be renamed Voltswagen. A day after the publication, it turned out that it was only a marketing move to attract attention to the ID.4 electric car, which entered the American market. Volkswagen wanted to be the first automaker to celebrate April 1, according to The Wall Street Journal, but the joke went too far.
From the message that appeared on the American website, it followed that Volkswagen of America will change its name to Voltswagen of America in May 2021. The rebranding was explained by the change in the vector of the company’s development towards electric mobility. Also quoted by the President of Volkswagen of America Scott Keogh: “We may be changing the letter K to T, but we are not changing the brand’s commitment to creating best-in-class vehicles for drivers around the world.
A source from The Wall Street Journal explained that the automaker did not plan to mislead the public, and the mention of the Voltswagen is associated with the entry of the ID.4 electric car into the American market. Thus, the company wanted to play with the word “volt”, meaning the unit of measurement of electrical potential.
The news, which at first glance seemed like an April Fool’s joke, was believed, among other things, because Volkswagen is really heading for the electrification of the model range. Thus, by the end of this decade, the brands that make up the concern expect to bring to the market about 70 electric models.
We also advise you to watch a detailed test drive of the VW Touareg 4.0 TDI V8 from the FineAuto team:
Contacts of all Volkswagen dealerships in Ukraine

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text:
The Brightness of Air is part of my geometric series, which explores the subtle balance between strength and flexibility, order and chaos, structure and freedom.
These geometric abstract oil paintings give color and form to the deeply human conflict between darkness and light.
Immerse yourself in worlds of lines and shapes that remain elusive even as they gradually reveal their inner secrets.
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domain: artistic


text:
Peter Kamya, the former owner of Simbamanyo House is at the losing end of another court case involving a multi-billion property. Kamya was sued by Bahamas Investment Ltd who ran to court to recover Shs1.3bn as part payment they had made to Kamya’s property comprised in Kyadondo Block 255 Plots 126 and 213 at Munyonyo in August 2015.
On top of asking Kamya to refund the Shs1.3bn with 25 per cent interest per annum dating back to 10th October 2016, court has also compelled Kamya to pay a further 6 per cent interest in general damages from date of judgement until the amount is settled in full.
The matter heard before Hon. Justice David Wangutusi of the Commercial Court in February this year, arose from a transaction agreement that Kamya reneged on.
According to the sale agreement, Kamya was supposed to deposit the original title with Equity Bank upon receiving the Shs1.3bn so that the bank could process a loan of Shs3.79bn as top up for the agreed purchase price of 5.09bn.
Kamya did not meet his part of the bargain and attempted to sell the same property to Bank of Uganda, prompting Bahamas Investment to lodge a caveat on the property.
Kamya instead terminated the contract in a letter dated October 20, 2016, with reason that it was already a year since they had entered into contract and he was supposed to receive the balance in 90 days, which hadn’t been the case.
In his judgement, Justice Wangutusi faulted Kamya for terminating a contract yet he had not fulfilled his end of the bargain of depositing the title with Equity Bank. Wangutusi reasoned that the 90 days were supposed to be taken into effect, starting the day Kamya had deposited his title with the bank.
Bahama’s Investments being foreign owned, Kamya had also used the legal gymnastics of a non-citizen not being allowed to own mailo and freehold land in Uganda to refer to the sale agreement as illegal.
However, Justice Wangutusi faulted him, citing that the issue had been taken care of in the agreement and Kamya was supposed to transfer the property’s mailo land interest to Bahamas lawyer Paul Muhimbura who would in turn issue a 99-year lease to Bahamas.
“This was a commercial venture which in my view attracts a commercial rate interest. Taking all circumstances into consideration, I find an interest rate of 25 per cent per annum in respect of special damages appropriate. I also find a six per cent per annum on general damages appropriate,” Wangutusi ruled.

domain: law


modem firmware releases notes?
im trying to find the modem firmware releases notes but dont see any. The releases annoucement for 48829 just says "This new firmware release is much more stable than previous CAT-M1 releases" but what are the actual changes? I dont want to blindly update my modems. im currently on v41065, is 48829 the next step up or are there other releases in between? the new pycom chips have 50523 but i see no releases notes for those either
@Gijs the modem manufacturer gives pycom no notes on what they are giving to you? that seems weird. I assumed the stability notes are what the manufacturer told Pycom but thats not even the case - you are saying you have no clue what the changes are but through manual testing yourselves? How is this okay?
@Gijs I hope that means upcoming products (Pygo, F01...) don't use the same modems. If the chip manufacturer can't provide decent docs that puts you in a very awkward position...
Unfortunately we dont have access to any release notes of the LTE modem firmwares either. From testing, we're able to discern the stability and connectivity etc.


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Best American Restaurants in Philadelphia
Best Italian Restaurants in Philadelphia
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Enjoy great restaurant specials, set menus, and more
Another outstanding dining experience at TALK! Mushroom duo, oysters, duck, and filet were the stars on this visit. Thoughtful, clever ingredient combinations. Exceptional cocktail menu and wine list. Delicious desserts - we suggest getting one of each! TALK is a great new gem in Philly. MoreOpenTable Diner -
My husband and I wanted good food in a cozy restaurant that was not overpriced. We got want we wanted and more! From the warm crusty bread to the perfectly prepared salmon and delicious tartufo--we loved it all. We even got complimentary cocktails because we booked online. Excellente, Bellini Grill! MoreOpenTable Diner -
Diners' Choice Winners: Best Overall
Philadelphia's best restaurants based upon thousands of OpenTable diner reviews
New to OpenTable
Philadelphia restaurants that recently joined the OpenTable network
Chalaco’s is a Peruvian Restaurant & Pisco Bar, inspired by the bars of Callao, which is the most important city port of Peru and South America. Our menu includes a variety of the most popular ceviches and other favorite Peruvian platters. Our bar is sorted out with one of the widest varieties of piscos and pisco cocktails on the east coast. The design includes a combination of wood and concrete, comfortable lightning, and designs inspired by Peruvian culture.More
Classic Italian tradition meets sophisticated Roman style at Giuseppe & Sons, an all-day ristorante by Schulson Collective. At Giuseppe and Sons, a new concept from Schulson Collective and Termini Brothers Bakery, you can expect Italian traditions paired with signature Schulson Collective hospitality and Home Studios design.More
Revel Social Lounge is known for its high energy, elevated services. Offering a variety of experiences from after work networking and late night VIP Reservations to Social Celebrations. Revel Social Lounge is the perfect weekend destination for your special occasion such as Birthday, Engagement and Bachelor or Bachelorette Party.
Revel Social Lounge is dedicated to providing exceptional products and services and serves a well-balanced crave worthy menu complete with Breakfast, Lunch and Dinner Menu. The innovative Cocktail Menu is made up of specialty cocktails created with only the finest ingredients, fresh squeezed juices and garnishes. The wine and champagne list has been carefully selected for both the novice and most seasoned taster.
The Revel Social Lounge Team looks forward to providing you and your guests the ultimate Revel Social Lounge Experience!More
Meet me at The Deck — New Hope's new gathering place offering gastropub fare, a full bar, and a broad and balanced beer list. Our menu features modern twists on classic fare ... made from scratch, seasonally driven and locally sourced. We offer a variety of brews on tap, as well as great local IPAs, signature craft cocktails and an extensive wine list. Located behind (and attached to) Bucks County Playhouse, THE DECK Restaurant and Bar is open for lunch, dinner and late nights. Offering great pre-theatre and post-theatre dining, The Deck also welcomes walkups looking for an outstanding every day dining experience. More
At the William's Spanish Restaurant you can rest assured that our cuisine is of the highest quality. We are new to the Bethlehem Pennsylvania area and we have excellent Spanish cuisine, with dishes representing regions of Latin America From our amazing mofongo to our juicy tender pernil, you will not be disappointed with our authentic kitchen. Our chefs only use the best ingredients to make the dining experience a pleasure and their many years of experience cooking will enchant your appetite.More
No longer just NYC’s 8th borough, Philadelphia is a well-kept secret, especially when it comes to food. Sure, you can still get a cheesesteak or its lesser-known, debatably better cousin—the roast pork sandwich—but the restaurant scene has taken off in recent years, with Israeli, vegetarian, and Spanish food in the mix. The provolone-lined cheese shops of eras gone by exist in bigger, better versions and the large, welcoming brasseries that dot Rittenhouse Square make you feel like you’re in Paris. Reading Terminal Market pays homage to Lancaster County’s Pennsylvania Dutch fare, with a bounty of pretzels and apple butter, while local bakeries, baristas, and breweries set a high culinary bar for the City of Brotherly love.

domain: food


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Creekside Cabin Rental Minutes from Yellowstone National Park in Gardiner, MontanaGardiner, Montana (United States of America)
Creekside Cabin Rental Minutes from Yellowstone National Park in Gardiner, Montana
"We enjoyed our stay at the creekside cabin! The cabin was clean, beds were comfy and we enjoyed the hot shower! The area is beautiful and we enjoyed …"
This creekside cabin rental is located four miles north of Gardiner, Montana, and can accommodate four adults in two queen beds and one child-size rollaway bed. There is one bedroom, a shower house, and a portapotty outhouse. The bedroom has two queen-size beds and a small roll away bed for a child. The shower house, which is not available during the winter, has hot water, shampoo, and towels. There is a dishwashing station and a portapotty outhouse that is serviced weekly. Linens and towels are provided. There is a small shack that has a coffee pot, one electric burner, a toaster oven, and two outlets to use.
In the main room, guests will find a table, chairs, a hutch, and a wood stove. There is a coffeemaker, dishes, utensils, limited pantry items, two five-gallon buckets to store food (otherwise guests should store food in their vehicle), and a mesh bag that can be used to keep items cool in the creek. Other amenities include Wi-Fi.
Outside, there is a campfire ring with wood (guests should leave money in the gift shack for what was used), a clothesline, and a propane barbecue.
This 13-acre, partially-wooded property is an outdoor playground. The hosts provide fishing poles, life jackets (mostly kid-sizes), inner tubes, and panning for gold supplies for no charge so that guests can take full advantage of the Yellowstone River across the street. The hosts are not liable for any free use equipment.
The Little Trail Creek borders the rental and there also a shallow pond on the property. Depending on the season, glampers can hike, trail run, cross-country ski, or snowshoe straight from the property. There are also horses, a fish pond, and friendly cats on the property to enjoy.
- Shared Barbecue
- Linens and pillows
We clean everything for the CDC guidelines. I have been a nurse for over 20 years. I understand the importance of a clean environment.
Check-in: 04:00 PM
Check out: 11:00 AM
Infants allowed Under 2 years old
Children allowed 2-12 years old
Some spaces are shared
This is a non-smoking property.
Be kind to the environment and take care of the surroundings.
Location and surroundings
Gardiner, Montana (United States of America)
Detailed location provided after booking
- Hot springs
- Winter sports
- Water sports
- Horseback riding
- Whitewater rafting
- Stand-up paddleboarding
- Wildlife watching
- Feeding animals
Glampers can hike, play in the creek, enjoy the stunning view of Electric Peak, tube in the Yellowstone River, cross-country ski, float in the pond, and feed horses without even getting in their car. Only four miles to the historic Roosevelt Arch at the northern entrance of Yellowstone National Park, guests can stop on the way to Mammoth Hot Springs, which is 20 minutes away, to swim in the Boiling River during the summer. Lamar Valley, the Serengeti of the United States, is less than an hour away. Gardiner, Montana, is less than 10 minutes away and is a hub for river rafting, horseback riding, wildlife tours, photography tours, fishing trips, and more. Backcountry cross-country skiing and snowshoeing trails are a short drive away. The possibilities for outdoor adventures are endless! If guests are looking to pamper themselves, there are many shops and restaurants in Gardiner and a soak in Chico Hot Springs Resort and Day Spa is less than 40 minutes away.

domain: travel


text:
Home▶ Diner Mug - Tim Denee Series
Diner Mug - Tim Denee Series
Our 2nd artist series of the classic diner with designs from Tim Denee.
Our latest series of diner mugs feature illustrations by Tim Denee. Tim is a Wellington-based designer and illustrator who has worked on book covers, calendars, posters, and magazines. He favours strong shapes, bold colours, and uplifting themes.
Each mug features one unique illustration by Tim with the Coffee Supreme logo on reverse.
This is our 2nd artist series of the classic diner mug printed by the leading US based military mug company, Military Art Career Collectables, who have printed all authentic diner mugs since 1967.

domain: design


JED - June 2011 - (Page 68)
Spectrum Warfare – Part 2
By Dave Adamy
The Journal of Electronic Defense | June 2011
ast month, we discussed the impact of location on the application of (or defense against) kinetic weapons. This concept requires that distributed assets be networked – which requires connectivity. Because of our dependence on connectivity in our daily lives and business, an enemy can also cause us real damage by attacking the connectivity itself. Consider the economic impact of having our banking system, our rail infrastructure or our air transportation capability shut down. All of these, along with many more aspects of our modern economic and military capabilities, are so dependant on connectivity that a radio frequency or cyber attack could cause significant physical damage, loss of military capability or devastating disruption of economic activity. Before discussing attacks on connectivity in more detail, it will be useful to discuss the nature of connectivity from a technical point of view. Connectivity can be thought of as any technique for the movement of information from one location or “player” to another. The medium can be wire, radio propagation, optical propagation or audio propagation. We must also consider the most basic connectivity; Between two people, two devices (e.g., computers) or between devices and people.
All of the simplest techniques share the advantages of simplicity of implementation and robustness. It is very hard to “jam” this kind of connectivity. It also requires that an enemy be relatively close to intercept transmitted information. That said, security requires diligent measures to prevent an enemy from successfully employing techniques like hidden microphones or cameras, or even monitoring reflections from lasers bounced off windows. However, all of these simple connectivity techniques have the immense disadvantage of short range. Increasing the range requires sending a messenger or relaying the information. Both techniques cause significant increase in complexity, reduce security against interception and reduce the reliability and confidence in the accuracy of the information passed. Thus, it becomes advantageous, even necessary, to employ technical transmission paths and techniques to extend the range – perhaps by a few kilometers or perhaps to some significantly different part of the Earth.
Regardless of which connectivity technique is employed, from the simplest to the most complex, the requirements
The most basic connectivity
In its simplest form, connectivity can be one person talking (or yelling over a distance) to another person, or optically transmitting information. Examples of person-to-person optical transmission are writing on a surface for others to read, holding up a sign, code with a steady or flashing light and use of signaling flags (or perhaps smoke). All are, in fact used to some extent in almost all of the most sophisticated military and civilian systems. Even when more technical transmission techniques are used, the input of information from humans is by voice or physical input of data from a keyboard or other touch device. Getting the information to another human being can only be done through the senses of hearing, vision or touch.
Optical Information BW ~ 375 GHz 24 pictures/sec
Audible Information BW ~ 15 kHz ~ 240 words/min
Figure 1: Human connectivity is limited by physical bandwidth and data format factors.
Table of Contents for the Digital Edition of JED - June 2011
JED - June 2011
The View From Here
From the President
The World’s SIGINT Aircraf
Upgrading Fighter Aircraft
Country Profi le: France’s EW Programs
Technology Survey: Airborne Dispensers and IR Expendables
2011 AOC Election Guide
AOC Membership Page
Index of Advertisers
JED Quick Look
JED - June 2011


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text:
One of the best creations of our time is the development of public transport. This service is in some cases available to the public for daily use for a fee. Transportation options often involve buses, taxis, inter-city rail, subway, and in some cases ferries.
Some people even use many options at the same time to achieve their goals. Most public transport operates on schedule to ensure everyone has a chance to connect. You can also check this link right here to know more about public transportation in South Florida.
Image Source: "Google"
If you think about how our world is constantly changing and developing, you can thank public transportation. A good public transport system differs from regional infrastructure and can vary by city, state, and even country. Depending on where you live, determine the type of system you use.
Some areas use traditional bus systems. The bus system was one of the earliest travel options in the early years. Most people still use this method. The reason people love taking buses is because of the routes they take.
Buses take you to the streets and allow quick stops to get other things done, like walking to the local grocery store, bank, or even grab a bit of fast food.
Another means of transportation is a Taxi. Taxis have also been around for a long time. With this method, you can hire a driver to take you to your destination without worrying about having to stop from one stop to another, as do the bus and subway systems. The convenience of traveling is a little better by taxi.
There are some people who prefer only to use public transportation to get around. Not because they can't afford it, but because of convenience. The fact is public transport works well for many people and is important for protecting nature.

domain: geography


text:
LOUISVILLE, Ky. (WDRB) -- With two games remaining in the regular season, Indiana already has more victories (7) then they've had in a dozen years. The Hoosiers are already going bowling for the first time in the Tom Allen era, and after a near miss last week at Penn State, they have another chance to add a win that could resonate through the years and help mark the 2019 team as one for the ages in Bloomington.
Yes, they play an additional game or two depending on the years you're comparing, but in the history of Indiana football dating back to 1899, there have been exactly seven seasons with more than seven victories. The Hoosiers have three more chances to get beyond that number this year.
They host Michigan this Saturday then close the regular season at Purdue on Nov. 30 before playing in a to-be-determined bowl game. The high mark for wins in a season was nine in 1945 and 1967.
All three of Indiana's defeats have come to ranked opponents (Ohio State, Michigan State, which was ranked 25th at the time, and Penn State). The Hoosiers get their last shot at a ranked team this week against 8-2 Michigan. The Wolverines are 13th in the latest college football playoff rankings. They've won three straight and have beaten Indiana 23 straight times.
The Hoosiers have been very close to ending that streak with overtime defeats the last two times the Wolverines visited in 2015 and 2017.
"I just think that they're just playing with a high level of confidence, and they're executing their scheme better, and guys are getting open and getting the ball to open receivers and protecting the ball better," Allen said about Michigan's improved play. "They had issues with that early on. Haven't really had issues with that lately. That's a big deal. You start turning the ball over, then a lot of bad things happen."
There are 16 seniors who will suit up for the last time in Memorial Stadium.
"I just think it's been neat to see the guys buy in," Allen said. "It's been neat to get to know these guys and be able to invest in their lives and make an impact in them that's going to be way beyond what happens on game day. And that's a big reason why I do what I do, and it's just a unique environment when you're not the one that brought them here."
Kickoff is 3:30 p.m. Saturday in Bloomington as IU bids for win No. 8.
Copyright 2019 WDRB Media. All Rights Reserved.


Russia ready for dialog with US on Dima Yakovlev Law — top lawmakerRussian Politics & Diplomacy January 18, 14:57
Lavrov says Russia ready to cooperate with US in areas where their interests coincideRussian Politics & Diplomacy January 18, 14:50
Moscow welcomes Jaysh al-Islam group’s readiness to join talks with DamascusRussian Politics & Diplomacy January 18, 14:18
Crimea’s head invites French presidential contender Le Pen to visit peninsulaRussian Politics & Diplomacy January 18, 14:05
Lavrov says EU countries’ leaders openly interfered in US election campaignRussian Politics & Diplomacy January 18, 13:52
Russian top diplomat believes OSCE may play important role in settling Ukrainian crisisRussian Politics & Diplomacy January 18, 13:29
Iran strongly opposes US participation in Syria talks in Astana — leader’s advisorWorld January 18, 13:28
Press review: Trump terrifies Western elites and Alibaba eyes partnership with SberbankPress Review January 18, 13:00
Kremlin knows nothing about Snowden’s intentionsRussian Politics & Diplomacy January 18, 12:50
“We will not perceive this law. This does not concern us as it is signed by the president of another country. We are set to hold elections on November 2. We are determined for independence. We believe that our territory has been illegally occupied,” Zakharchenko said.
Ukrainian President Petro Poroshenko on Thursday signed a law granting special self-rule status to certain areas in eastern Ukraine's Donetsk and Luhansk regions for three years. The document is stipulated by agreements reached in the Belarusian capital Minsk in early September.Boris Litvinov, who chairs the DPR’s parliament, the Supreme Council, also said on Friday that the self-proclaimed republic will go its own way despite the law on the special status.
DPR’s first deputy prime minister, Andrei Purgin, said the signing of the law by Ukraine’s president is a positive step, but it is unlikely to influence the political situation in the republic.
The law on the special status of the Luhansk and Donetsk regions, which was passed by the parliament in mid-September, guarantees the right to freely use and study Russian or any other language in Ukraine. It also states that local elections are to take place on December 7 to establish new councils in districts, cities and villages.


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Meghan Markle and Prince Harry to keep royal baby’s birth ‘private’, Kensington Palace announces
THE Duke and Duchess of Sussex will not announce the birth of their royal baby straight away, it has been announced.
Kensington Palace has said that the couple will keep the birth ‘private’ until they’ve had chance to celebrate ‘as a new family’.
In a statement released today, Meghan and Harry’s household said: ‘The Duke and Duchess of Sussex are very grateful for the goodwill they have received from people throughout the United Kingdom and around the world as they prepare to welcome their baby.
‘Their Royal Highnesses have taken a personal decision to keep the plans around the arrival of their baby private.
‘The Duke and Duchess look forward to sharing the exciting news with everyone once they have had an opportunity to celebrate privately as a new family.’
The royal baby is due in the next few weeks.
For all the latest news, traffic and travel, what’s on, Pompey, sport and breaking stories visit The News’s website.
We will be bringing you all of the latest stories from across Portsmouth and surrounding area throughout the day.
Do not contact us while you are driving. To stay up to date with all the latest Portsmouth news follow us on twitter @portsmouthnews or like our Facebook page.
Sign up for our WhatsApp service to get the latest news direct to your phone.

domain: celebrity


SALT LAKE COUNTY, Utah, Jan. 31, 2021 (Gephardt Daily) — A woman rammed a Unified Police Department vehicle while trying to flee from officials on steel rims in the early hours of Thursday morning.
A probable cause statement from the 3rd District Court of Salt Lake County said Kenedi Trujillo Tanpirak, 24, is facing charges of:
- Aggravated assault targeting law enforcement, a first-degree felony
- Receive or transfer stolen vehicle, a second-degree felony
- Failure to respond to officer’s signal to stop, a third-degree felony
- False personal information, a class A misdemeanor
A Unified police officer located a suspicious vehicle parked on the east side of the Discovery Inn at 380 W. 7200 South in Midvale that matched the description of a reported stolen vehicle, the statement said.
The officer saw a woman, later identified as Tanpirak, and a man get into the vehicle and drive east on 7200 South from 300 West. As the officer was following the vehicle, other officers positioned themselves ahead of it, preparing to deploy tire deflating devices.
As the suspect vehicle, driven by Tanpirak, approached the intersection of 7060 S. State St., an officer deployed spikes ahead of it. The suspect slowed the vehicle, observing the spikes, but then accelerated and passed over the top of them, resulting in all four vehicle tires going flat.
The suspect vehicle continued to flee north on State Street as all four tires lost their rubber and the vehicle continued on steel rims, the statement said. The suspect driver entered the oncoming lanes of State Street still traveling north, and began to lose control.
In the area of 5900 S. State St., the suspect vehicle crossed back over into northbound lanes but could not maintain control and spun around to face south. An officer then stopped his police vehicle in front of the suspect vehicle and Tanpirak accelerated rapidly and rammed the suspect vehicle into the front of the patrol vehicle.
Tanpirak then accelerated again, causing the tires to spin and emit sparks, but eventually came to a stop. When officers took Tanpirak into custody, she gave them the wrong first name and the wrong birth date. Officers subsequently found she gave her sister’s information.
She also told police: “I wanted to stop, but my boyfriend made me go! He told me the car was stolen and to not stop!”
Tanpirak “has a long history of providing false information to law enforcement when arrested,” the statement said “In December of 2020, this female suspect was arrested twice for being in possession of a reported stolen vehicle and during each of those incidents, was successful in providing false information to officers using her younger sister’s information.”
She was transported to Salt Lake County Jail, where she is being held without bail.


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It’s only been one month, but Tyrese Haliburton has already proven to be one of the steals of the NBA Draft and a top contender for Rookie of the Year. Haliburton is fourth among rookies in scoring and second in assists despite being selected 12th overall.
Haliburton also is second on the Kings in assists and steals, first in 3-point percentage, and third in field-goal percentage behind their two centers, Richaun Holmes and Hassan Whiteside. The rookie is already an integral part of the franchise despite being two months into his Sacramento tenure.
On a recent episode of the “All the Smoke” podcast with former King Matt Barnes and Stephen Jackson, De’Aaron Fox said that Haliburton’s maturity and feel for the game already stick out despite having to jump in after a shortened training camp and preseason:
“He’s been great, you would have thought he’s in his second or third year the way that he’s out there playing. And for these rookies to not get any Summer League, a short training camp, just come in and you got your team, you find out who you was playing with a month before the season starts. That’s a lot of adversity that you really got to overcome.”
Haliburton’s impact came almost immediately, and Fox was impressed by his rookie’s performance in the season opener, as he relayed on the podcast:
“Man his first game in the league, he played an overtime game in Denver, and you know it’s tough to play in Denver. He really showed that he’s built for this, and he really can. He understands the game so well. He runs the pick-and-roll extremely well, he’s a good shooter, like you say, he does everything extremely well for us.”
Haliburton has been complimentary of Fox during his brief time in the NBA, and clearly, the feeling is mutual, which bodes well for the pair’s partnership moving forward. It also helps that the Kings nailed their first pick for the second time in four seasons. It’s already obvious that Haliburton is made to last in this league.
More news for Friday:
- The Kings play tonight, but ICYMI, both their games in Memphis were postponed as the Grizzlies shut down for contact tracing.
- Bleacher Report ranked Fox and Haliburton in their top 10 duos under 25 years old.
- Jason Anderson dives into some of the team’s defensive issues.
- In real estate news, Vlade Divac is selling his Sacramento home.

domain: sports


As well as a streaming boom, the Covid-19 pandemic has seen fewer transactions involving cash. That has resulted in smartphone mobile payments experiencing a surge in growth this year. The Statista Digital Market Outlook has forecast that the value of smartphone mobile payments is set to continue increasing in the years ahead, with 28 percent growth predicted between 2019 and 2024.
You will find more infographics at Statista
Telework should be taxed, Deutsche Bank report suggests


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Skin Cancer Antibodies
Skin cancers are the 6th most diagnosed cancers in the United States, with about 4.5% of all new cancer cases classified as melanoma of the skin, resulting in approx. 1.7% of cancer deaths yearly. As of 2012, there were approximately 997,000 people living with skin cancers in the United States. Those diagnosed with skin cancer have a 5 year survival rate of 91.5%. Over the last 10 years, the new cancer case rate has risen an average of 1.4% each year but the death rate has been stable. Biocare Medical is proud to offer key dematopathology antibodies that may aid in the identification of their respective proteins by IHC in FFPE tissues.
SEER Cancer Statistics Factsheets: Melanoma of the Skin. National Cancer Institute. Bethesda, MD, https://seer.cancer.gov/statfacts/html/melan.html

domain: medical


Patients across Virginia are fighting every day to stay healthy and have access to affordable medication. Many patients arrive at the pharmacy counter to pick up their prescriptions only to be faced with high out-of-pocket costs that many may not be able to afford. Out-of-pocket costs are any expenses paid for a prescription that aren’t covered by insurance plans. For many, especially those with chronic conditions, innovative medical treatments can make all the difference in their ability to lead healthy, productive lives. And yet, high out-of-pocket cost burdens associated with their essential treatments are keeping them from being able to access their medications.
Thanks to new innovative treatments, many diseases that were once fatal are now being treated as manageable chronic conditions and, for other diseases, new treatments have greatly increased average life expectancy. However, under many health insurance plans, patients living with chronic conditions are required to pay thousands of dollars in out-of-pocket costs to access the treatments their health care providers have prescribed. This is true for medications used to treat cancer, HIV/AIDS, arthritis, multiple sclerosis and other debilitating and life-threatening diseases. When high out-of-pocket costs become a barrier to access, patients find themselves facing difficult decisions about whether to take medically necessary treatments or to risk their family’s financial stability.
When Virginians pick up their medications from the pharmacy, they shouldn’t be confronted with high out-of-pocket costs, leaving them to choose between their health and financial stability. Virginia patients, especially those living with chronic illnesses, deserve affordable access to the medications and drugs they rely on to live healthy and productive lives.
Virginians should not have to delay or forgo treatment simply because of high out-of-pocket costs. The Virginia General Assembly must increase protections to ensure patients have access to high quality, affordable care. Virginia legislators support legislation that limits the out-of-pocket costs Virginians are required to pay for each prescription. The Virginia General Assembly already passed an out-of-pocket cost cap for insulin in 2019, and should now focus on expanding out-of-pocket cost caps to limit how much Virginia patients are paying from their own wallets.


Invention of the Electric Washing Machine
The first electric washing machine, “The Mighty Thor,” was built in 1908 by Hurley Machine Company.
The invention of the electric washing machine designed for home use would eventually contribute to the decline of industrial laundry in the United States. Other contributing factors would be post-war developments in manufacturing, rising incomes, and a domestic culture increasingly centralized on commodifying basic human needs.
Shown is an ad for a Thor washing machine from 1920, the same time period that laundry was experiencing mass worker unrest, and the same year the Home Service Company was formed as a way to consolidate commercial laundry interest.


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The last Adventure Mission in the Honkai: Star Rail quest line titled ” Vessel of Mediocrity (Part 3) ” concerns Cyrille, a child who was prepared to become the eighth Supreme Guardian of Belobog. You must put the shadow of her soul to rest in the final chapter of her terrible story. This article will guide you to complete objectives in vessel of mediocrity ( part 3)
|Jarilo-VI , Everwinter Hill
|Trailblaze level 24 and Have completed the Jarilo-VI main story.
Make your way to the Silvermane Guard Restricted Zone area of Jarilo-VI to start part 3 of the “Vessel of Mediocrity” adventure mission. In the extreme southern portion of the Silvermane Guard Restricted Zone, speak with Dunn (NPC) to begin the task.
Speak with guardian Shadow
make your way to Everwinter Hill in the Belobog Overworld. Interacting with the guardian shadow will reveal that it is Cyrille. Then Cyrille will request your help once more in solving the Fool’s Box puzzle
#1 puzzle solution
for 1st cyrille
Start the puzzle by pushing the leftmost box three times upward until it is up against the top of the grid.
After that, move the box obstructing the 1st child on the left to the right once. Then rescue her
for 2nd cyrille
Push the box ( marked with red arrow in the below screenshot) right side once.
now push the boxes marked with yellow arrow down once and Rescue the 2nd child.
for 3rd cyrille
push the box ( marked with white arrow) upward once
then push the box with yellow arrow ( which is in front of 3rd cyrille ) down once. Then rescue the 3rd cyrille.
for 4th cyrille
now push the box ( which is in front of 4th cyrille) right once and rescue the cyrille.
Collect the chest
For the Vessel of Mediocrity questline, completing every Fool’s Box puzzle will award you with the achievement The Banality of Evil and 5 Stellar Jade.
Defeat the Guardian Shadow
When you’ve finished the riddle, speak with Cyrille. She will ask you to grant her peace that lasts forever. After the discussion, a war will start. Defeat the Cyrille (Guardian Shadow) and her two Everwinter Shadewalker defenders.
Go to the Overworld and find someone well-versed in history
Go to the Administrative District next, where Manya will be waiting in front of Serval’s workshop. Interact with her and select the dialogue option, “Do you know the Supreme Guardian Cyrille?” Complete the conversation to receive a reading of Cyrille: Cyrille “The Fool,” completing the series of adventure missions.

domain: hobby


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Aston Villa boss Paul Lambert will be seeking a response when his side host Newcastle United on Saturday.
Lambert's men began their Premier League campaign in style with a 3-1 victory away at Arsenal on the opening day, but the wheels have fallen off somewhat since then.
They suffered a narrow 2-1 defeat against Chelsea at Stamford Bridge before going down 1-0 to Liverpool in their last Premier League outing, courtesy of a strike from in-form Daniel Sturridge.
A three-week break from league action for the international fixtures should leave them refreshed ahead of the visit of Alan Pardew's side, although they will be taking nothing for granted.
Last season's 2-1 loss to Saturday's opponents aside, their home record against Newcastle offers some grounds for optimism.
They were unbeaten in five on home soil prior to that and only three times in the past 16 years have Newcastle scored more than once at Villa Park.
Lambert has made a number of additions in the close-season to ensure that they do not endure another repeat of last season's struggles, when they narrowly avoided relegation.
And one of them, Czech Republic striker Libor Kozak, could be handed his debut on Saturday.
The forward joined from Lazio in a £7million deal on transfer deadline day and Lambert is backing him to be a success.
"I know he can score goals," said the Villa boss.
"He’s a handful, he's played in a league renowned for some of the hardest defending you can come up against.
"I don’t bring players in to say: ‘You can sit on the bench for six months.’
"He’s here to help and that’s what he’ll do.
"We’ve got options now. I can do what I want because he's a No.9, which is what I think we’ve needed."
Defenders Nathan Baker and Antonio Luna could also feature for Villa after recent knocks, while Newcastle could welcome back Yohan Cabaye.
The Frenchman was linked with a move away from the club in the transfer window, but a potential switch to Arsenal never materialised.
He looks set to be recalled at Villa Park, while Loic Remy could be handed his first start since joining on loan from QPR.
The striker has been hampered by a calf injury since making the move but Pardew said: "I think he's got enough in the tank to be considered for a start. At some stage he needs to be pitched in.
"Since Demba (Ba) left, we've lacked a player that has increased our goal threat.
"With all due respect to the players that we have, we need a player that can put the other team on the back foot. I think Remy does that.
"We've got Papiss Cisse, Shola Ameobi and Yoan Gouffran to complement that. I think hopefully they will all stay fit."
|8||K. El Ahmadi|
|Coach: P. Lambert|
for J. Okore 30'
for K. El Ahmadi 67'
for A. Weimann 88'
|Swansea well beaten by Bournemouth|
|Pellegrini concerned by ´high risk´ pitch|
|Poyet issues Wickham warning|
|Ramos makes Dortmund bow in Chievo win|
|Medel agent in Cardiff to discuss Inter deal|
|Remy to join up QPR squad|
|Falcao to feature against Valencia|
|Wenger brushes off Balotelli rumours, Gerrard claims|
|Blanc stresses Trophee des Champions importance|
|Pardew hopeful of Ferreyra loan|
|Leeds to meet with police to discuss outstanding fees|
|Bernabeu redevelopment plans halted by Spanish court|
|Malaga complete Ochoa deal|
|Man arrested over match-fixing claim in Bulgaria|
|Osvaldo could join Inter in Taider swap|
|Murcia denied Segunda participation over financial woe|
|Guardiola delighted with Guadalajara triumph|
|Wenger rules out Quintero capture|
|Ansaldi joins Atleti on loan|
|Seferovic signs on at Frankfurt|
|Van der Vaart not ruling out QPR move|
|Hiddink eyes more Netherlands progress|
|Palace snap up free agent Hangeland|
|Davies competition can help me improve, insists Rose|
|Basanta completes Fiorentina move|
|Sporting slam Dier´s father and representative|
|Grenier denies missing training|
|Lazio bring Braafheid in from the cold|
|Leboeuf: Ibrahimovic should be PSG captain instead of Silva|
|Villa must heed Keane advice, says Lambert|
|Falque joins Genoa|
|Henderson: Gerrard is irreplaceable|
|Milner: I´ll stay if I´m playing|
|Samp swoop for Bergessio|
|Evans impressed by Van Gaal´s attention to detail|
|Cordoba sign Rossi on loan from Juve|
|Brondby ´will do everything´ to sign Agger|
|Seedorf ´still has Milan contract´|
|Blaszczykowski: Dortmund will always be number one|
|Mourinho hints at Cech exit|
|Osman sets sights on silverware|
|Sahin to miss Dortmund´s Bundesliga opener|
|Griezmann ´didn´t think twice´ about joining Atletico|
|Fletcher tips bright future for Herrera|
|Swedish defender Mellberg retires|
|Copa do Brasil Review: Vasco da Gama, Novo Hamburgo advance|
|Courteous Chelsea players welcome Courtois|
|UEFA to investigate fan violence in Kiev|
|Ribery shines as Bayern edge out Guadalajara|
|Lampard´s short-term future set to be decided|
|Villa wants to leave legacy|
|Cabaye fresh for PSG´s trophy assault|
|Pique: I am far from the world´s best defender|
|Schneiderlin staying put, says Koeman|
|Digne: PSG have acclimatised in China|
|Atletico say no to Torres, Hernandez|
|Mata buoyed by early form|
|Bruce rues calamitous Huddlestone miss|
|UEFA Europa League Review: Torino mark return with big win, Lyon victorious|
|Southampton win again|
|Jenkinson agrees West Ham loan|
|Tottenham agree Dier move|
|Rincon seals Genoa move|
|Dunne announces international retirement|
|Romulo close to Juve switch|
|Trencin 0 Hull City 0: Huddlestone pays penalty in Hull stalemate|
|Rennes prise Prcic away from Sochaux|
|CSL Preview: Liaoning look for swift response, buoyant R&F visit Henan|
|Pique desperate to regain high standards|
|Marseille agree three-year Stade Velodrome lease|
|Torres will not be leaving, says Mourinho|
|Bastia bring in Brandao|
|Paris Saint-Germain v Guingamp: League and cup winners battle for Trophee des Champions|
|Argentine Primera Division suspended after Grondona death|
|Immobile: Lewandowski is the past, I am the future|
|Rose pens new Tottenham deal|
|CSL Review: Evergrande end Harbin run, Henan edge clear of danger|
|Ivory Coast appoint Renard|
|Three-man shortlist for South Korea post|
|MLS Preview: Sounders aiming to bounce back against Earthquakes|
|Personal reasons behind Evra´s Juve switch|
|Liga MX Preview: Monterrey out to continue winning run|
|J.League Preview: Oenoki begins S-Pulse reign at Tokyo|
|K.League Preview: Jeonbuk face tricky Jeonnam test, Pohang visit Suwon|
|Kakuta loaned to Vallecano|
|Morrison remanded in custody|
|Hernandez coy on United exit|
|Neymar on road to recovery|
|Feyenoord capture Wilkshire and Basacikoglu|
|Yoel makes Valencia switch|
|Heaton extends Burnley deal|
|Lees leaves Leeds for Wednesday|
|Caballero eyes first-team action|
|Newcastle ´monitoring´ Remy, claims Pardew|
|Rodriguez ready to fight for Real place|
|Cavani ´certain´ he will stay with PSG|
|Morrison charged with assaults|
|Copenhagen slam security after fan violence in Kiev|
|Gerrard: Suarez ´too good´ for Arsenal|
|Mourinho explains Lukaku exit|
|Simeone content with Atleti workout|
|Milligan: Australia targeting Asian Cup|
|Ronaldinho rules out retirement|
|Rodgers challenges Henderson|
|Jovetic can be City catalyst - Pellegrini|
|Janko joins Sydney as marquee|
|Deila ´unbelievably disappointed´ with Celtic|
|MLS Review: DC close on Sporting, Red Bulls hold RSL|
|Ecuadorian Primera A Review: Emelec crowned champions|
|Bolivar 1 San Lorenzo 0 (agg 1-5): Visitors advance to maiden Libertadores final|
|Gerrard open to move abroad|
|Lukaku tells Chelsea ´no hard feelings´|
|Zaha eager to impress Van Gaal|
|Liverpool down Man City after shoot-out|
|Atletico fall to Gonzalez´s penalty heroics|
|Glazers offer up 8m United shares|


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Based on the groundbreaking study that shaved three years off a subjects’ age in just eight weeks, discover a proven, accessible plan to prevent diseases and reduce your biological age.
It’s true: getting older is inevitable and your chronological age can only move in one direction. But you also have a biological age, which scientists can measure by assessing how your genes are expressed through epigenetics. Exciting new research shows that your bio age can actually move in reverse—and Dr. Kara Fitzgerald’s groundbreaking, rigorous clinical trial proved it’s possible. By eating delicious foods and establishing common-sense lifestyle practices that positively influence genetic expression, study participants reduced their bio age by just over three years in only eight weeks!
Now Dr. Fitzgerald shares the diet and lifestyle plan that shows you how to influence your epigenetics for a younger you. In Younger You you’ll learn:
We don’t have to accept a descent into disease and unwellness as we age as inevitable: when you reduce bio age you reduce your odds of developing all the major diseases, including diabetes, cancer, and dementia. With assessment tools for determining your bio age, recipes, and plans for putting it all into practice,Younger You helps you repair years of damage, ward off chronic disease, and optimize your health—for years to come.


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Power of the Hills: Ruskin's Mountains
18 April - 23 September 2016
The magic of mountain landscapes, as captured by John Ruskin.
To John Ruskin, mountains were powerful evidence of a living Earth and a great inspiration. His fascination with them led him to reach a detailed understanding of their nature, through his own work as well as his reading of Wordsworth and his discovery of the work of J.M.W. Turner.
John Ruskin: Copy of Turner’s ‘Goldau’, 1855
This exhibition displayed some of Ruskin’s finest drawings and watercolours of mountain landscapes, from his childhood visits to the Alps in the 1830s to his tours in the 1860s in Turner’s footsteps. Also exhibited were subjects in and around his later home at Brantwood in the Lake District.
John Ruskin: Mountain Landscape, c. 1850s-60s


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VISSCHER, Nicolaes II (1649-1702) [and others]. Atlas minor, sive geographia compendiosa qua orbis terrarum per paucas attamen novissimas tabulas ostenditura. Amsterdam: Nicolaes Visscher, [1696 or later].
2 volumes. Folio (532 x 335 mm). 6 engraved titles, including a general title by Gerard de Lairesse HEIGNTENED IN GOLD and 5 allegorical regional engraved titles, for the Low Countries (Germaniae inferior), by Lairesse, Europe, Asia, Africa, and America, these four from Blaeu's Atlas Major, the last three HEIGHTENED IN GOLD, the first 3 unsigned, the America title signed by the engraver T. Falck, 186 full-sheet or folding engraved maps by Visscher, all with EXCEPTIONALLY FINE HAND-COLOUR BY A MASTER COLOURIST, POSSIBLY A PUPIL OF THE CELEBRATED DIRK JANSZ. VAN SANTEN the maps colored in outline with cartouches, decorative borders, embellishments, and landmarks fully colored, most undated, three maps dated 1696, two dated 1694 and one dated 1656, most double-page, 13 folding (1 1/2 sheets and smaller), the maps variously numbered in ink at upper left, lower or upper right, and/or on versos (the two volumes separately numbered) mounted on guards throughout. Loosely inserted is a full-sheet view-plan of Purmer by I. Leupenius (uncolored). Publisher's blind-stamped dark brown goatskin over pasteboard (rebacked, restoration to corners and board edges, some rubbing).
Provenance: Henry Grier Bryant (1859-1932), explorer and geographer, president and benefactor of the Geographical Society of Philadelphia, bookplate.
AN EXCEPTIONALLY FINE composite atlas, WITH EXTRAORDINARY LAVISH AND MASTERLY HAND-COLOURING, in the style of the celebrated Dutch colourist Dirk Jansz. Van Santen (1637/38-1708), whose manner is signified by rich and exotic colour combinations, added elements such as flowers to clothing, marbling to masonry, all found here: "... van Santen applied transparent and opaque colours at the same time in both mixed and pure tints. He often painted the whole surface of th map or illustration, transforming the graphic light and dark contrasts into colour. To dark areas representing shadows, clothing pleats or the 'repoussoir', the foreground of a landscape, he applied his characteristic shiny varnish; this had the effect of brightening the colour. He devoted a great deal of attention to skies and horizons, frequently making use of the same colour progression...." (Goedings).
Atlases and books coloured by van Santen are found in the libraries of the most prominent collectors of the golden age of Dutch cartography "...Bibles and atlases, bound in deluxe bindings by Albert Magnus (1642-1689) and decorated by van Santen were considered gifts worthy of princes. Travellers and poets wrote about this work" (Goedings).
This magnificent atlas is of the series of large atlases compiled and sold by the Visscher family of art dealers and cartographers at the end of the seventeenth and early eighteenth centuries. No two of the Visscher atlases seem to have been identical in content, and most contain, like this one, a selection of maps by the Visschers themselves as well as other cartographers. The present particularly extensive atlas, issued without the usual printed or manuscript index, was probably assembled and colored to order for a German or Dutch customer, the first volume being almost entirely devoted to Northern European maps.
The general contents are as follows:
1 celestial map by Ludovico Vlasblom after Johannes van Keulen,
3 world maps, consisting of two double-hemisphere maps, by Visscher (Shirley 406) and Carel Allard (Shirley 578), and Jacob Robyn's single hemisphere map on a projection centered on the North Pole (Shirley 582);
one map each of the North Pole (Jansson) and South Pole (unsigned, probably Jansson-Mercator);
160 European maps including Scandinavia (12), Germany, including present-day Austria and Switzerland (43), Low Countries (48), Britain (7), France (21), Spain and Portugal (5), Italy (12), Malta (1), and Eastern Europe (i.e, Russia, Livonia, Poland, Prussia, Hungary and Greece, 11);
6 maps of Asia,
4 of Africa,
and 10 maps of the Americas.
108 maps are by Nicolaes Visscher; the remainder are by Frederick de Wit (44), Hubert Jaillot (8), Carel Allard (7), Joan or J. and Cornelis Blaeu (6), Jan Jansson (2 or 3, see above), Gerard Valck (2), and one each by J. Robyn, Johannes van Keulen, J. Danckert, J. C. Berger, C. Specht, J. van Loon, and Johannes de Ram, plus an unsigned and unidentified map of the Cape of Good Hope.
The American maps consist of a general map of North and South America by Allard, Jaillot's individual maps of North America and South America (both dated 1694), Blaeu's map of Brazil, and 7 maps by Visscher, showing the northeastern tip of North America (New Brunswick, Nova Scotia, and the Gulf of St. Lawrence), the Eastern seaboard from Canada to the Carolinas, Novi Belgii (New England and Virginia, with an inset view of early Manhattan), the West Indies and surrounding landmasses, Jamaica, and Martinique.
The coloring of this copy, which is consistent throughout the atlas, is of an unusual somewhat somber palette emphasizing shades of dark green and purple. Visscher atlases of this scope, condition, and quality of coloring are RARE. Koeman lists 30 atlases published by the Visscher family from 1634 to after 1708; of these only two (Vis 27 and 28, both published by the widow of Nicolaes Visscher II) contain more maps than the present example. Goedings "Dirk Jansz. Van Santen...a survey" 1992. Catalogued by Kate Hunter


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Build a muffle (heating chamber) out of soft kiln bricks or fireplace bricks to trap the heat. Ask about kiln bricks at the clay store where you picked up the clay. Loose stack the bricks, there's no need for mortar. Kiln bricks are better (more insulative) for our purposes, but more expensive. Kiln bricks can be cut with a handsaw, fireplace bricks need brick cutting equipment. Since the bricks are loose stacked they can be repositioned in new configurations as the need arises.
Be aware that a propane torch uses a substantial amount of oxygen
Dempsey's Forge sells good safety/forging glasses. Get the #2 Green Filter Lenses.
Decarburization happens when hot steel oxidizes, creating a thin flaky oxide coating. HeatBath makes several water soluble stop-off protective coatings for steel, one of which is called No-Carb Green, which sounds like an eco-diet.
There are some special temperatures associated with steel called transformation temperatures. You don't have to learn their names or symbols, but it's nice to have some idea of what they mean.
When heating O1 steel (red line) at about 1350F Austenite begins to form. The rate of temperature rise slows as heat is being consumed to create this transformation. At about 1400F the transformation to Austenite is complete and the temperature rise resumes it's original rate. At the Peak Temperature, which is of our choosing, the steel is withdrawn from heat and begins cooling (blue line). At about 1295F Austenite begins transforming back into Ferrite and the rate of cooling slows as heat is being released during transformation. When the transformation is complete, 1240F, the original cooling rate resumes.
Some points about transformational temperatures:
All these changes, except the formation of martensite, occur at lower temperatures during cooling than during heating, and depend on the rate of change of temperature.
When a piece of steel is heated to Ac1, it continues to absorb heat without appreciably rising in temperature, although its immediate surroundings may be hotter than the steel. This is the decalescence point. Similarly, steel cooling slowly from a high heat will, at Ar3, actually increase in temperature, although its surroundings may be colder. This takes place at the recalescence point. The recalescence point is lower than the decalescence point by anywhere from 85 to 215 degrees F., and the lower of these points does not manifest itself unless the higher one has first been fully passed.
Now for Ac3. This is the important one, this is what everybody talks about. It's also called the critical temperature, the magnetic point, the Curie Temperature and so on. Call it Critical. When steel has transformed to Austenite it loses it's magnetic properties, it will no longer attract a magnet. And this is the test for Critical. It's not so important to know the temperature (the number) of Critical for the steel you're working with. You might be curious and want to know but otherwise it matters little. The magnet test identifies Critical and what it tells you that the steel has undergone a structural transformation, it doesn't actually say anything about temperature.
Each steel has it's own transformation temperatures, although for classes of steels these temperatures are similar.
Every material glows the same color at the same temperature. Whether it be steel, glass, ceramic or horse whiskers. This is just a fact of quantum physics. If you learn the color (see the chart below) of Critical for a particular steel and have a particularly acute eye and memory then you can identify Critical by sight alone--maybe. Everyone else should use a magnet to test for Critical.
There's one other temperature, but it's not in the graphic above. It's called Ms and it's the temperature at which Martensite starts to form, it's usually around 350-450F and Martensite formation progresses as the temperature falls.
We'll revisit this temperature stuff in the OzForging and heat treatment sections.
The temperature thing--how does one know steel temperatures with any degree of certainty?
The short answer is you don't. This is really the crux of hand forging, it's a craft rather than an industrial process. If you know the temperature within 25F you're doing very well, 50F is more like it. And things are always changing, the whole process of forging is dynamic rather than static.
You can know the Critical temperature by using a magnet. With careful heat control and a careful eye, you can know the decalescence and recalescence points. Borax melts at 1366F. Aluminum melts at 1220F. Use Tempilstiks, which are temperature markers that melt close to the specified temperature, get the 1300F, 1400F, and 1500F sticks. Beyond these, you're pretty much on your own.
If you want greater temperature control a kiln may be in order. Paragon sells knife making kilns. But then you're faced with the somewhat the same problem, how do you know is the dial is reading correctly? Try an Infrared Temperature gun if you want. The real test for temperatures and all the rest of hand forging is the results. If you create a knife which makes you happy, you must have done it right. To get all the things right, you'll have to go through about the same struggles steel forgers have all gone through since antiquity. You're not the first to wrestle with these problems.
Temperatures and Colors:
Using 1018 steel is a good way to become familiar with the colors of temperatures There are two color/temperature regions each arising from a different effect. While these color charts may not be perfect given different monitors, software, and the vagaries of the web, they'll give you an idea of the different color/temperatures.
In the forging-range, color is emitted by the steel. In the tempering-range, color is the result of oxides formed on the surface of the steel. To get a good reading in the tempering-range the oxides need to be filed or sanded off to allow new and current oxide colors to form. A quick swipe with a file or sand paper will do the trick. Practice seeing both sets of colors while forging 1018 steel.

domain: chemistry


Source: Health Policy Institute of Ohio
For the first time in more than two decades, life expectancy for Americans declined last year (Source: “U.S. Life Expectancy Declines for the First Time Since 1993,” Washington Post, December 8, 2016).
Rising fatalities from heart disease and stroke, diabetes, drug overdoses, accidents, and other conditions caused the lower life expectancy revealed in a report released by the National Center for Health Statistics. In all, death rates rose for eight of the top 10 leading causes of death.
Overall, life expectancy fell by one-tenth of a year, from 78.9 in 2014 to 78.8 in 2015, according to the latest data. The last time U.S. life expectancy at birth declined was in 1993, when it dropped from 75.6 to 75.4, according to World Bank data.
The overall death rate rose 1.2% in 2015, its first uptick since 1999. More than 2.7 million people died, about 45% of them from heart disease or cancer.
The report’s lone bright spot was a drop in the death rate from cancer, probably because fewer people are smoking, the disease is being detected earlier and new treatments have been developed recently, experts said.


text:
Title: Telephone Company Warehouse-packing and shipping, circa 1915-1916 |
Accession Number: 1984.187.2684
Category: PHOTOGRAPHS - SOFT NEGATIVES
Type: glass negative
Maker: Rosenfeld and Sons
Description: 8x10 glass plate negative photographed by Rosenfeld and Sons on January 1, 1915. Image of telephone company warehouse packing and shipping room. Visible in image: six men at table packing standing telephones in boxes with American Telephone & Telegraph Co. logos, a seventh man delivers more equipment, two men supervise the work. CREDIT LINE: Mystic Seaport, Rosenfeld Collection. Handwritten on original negative sleeve: "2684 / 214-12 / 1/1/15 / #4 / Box 214".
Mystic Seaport Image ID m404577 Information regarding reproductions

domain: history


text:
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LEAKED: Jewel Santini Video
Read PDF The Death of Santini: The Story of a Father and His Son DOWNLOAD FULL [FREE]

domain: entertainment


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A bright green comet that has not been seen since the last ice age will be visible in DFW skies later this month, The Dallas Morning News
reported. Manfred Cuntz, a UTA physics professor, said the comet, called C/2022 E3 (ZTF), is like “messengers from the super early solar system.” Cuntz recommended looking for the comet during early mornings when the sun is low. He said, “It’s literally speaking, a once in a lifetime chance.”
UTA international enrollment
The University of Texas at Arlington ranks No. 4 in the state in international student enrollment percentage, MSN.com
and the Houston Chronicle
reported. According to fall 2021 enrollment numbers, 11.8% of students are international, coming from 98 countries, including India, Nepal, Bangladesh, Vietnam and China.
Defense instrument grants
Four faculty members in the Mechanical and Aerospace Engineering Department at The University of Texas at Arlington have earned Defense University Research Instrumentation Program grants totaling nearly $3 million from the Office of Naval Research and the Air Force Office of Scientific Research, U.S. Fed News
reported. The researchers will use the funding to examine battlefield brain injuries, develop customized instrumentation to replicate microscale manufacturing conditions and increase the power supply to UTA's arc-jet-heated hypersonic wind tunnel, which is used in research on counter-hypersonic laser technology.
Scientists from The University of Texas at Arlington, University of Arkansas and the U.S. Geological Survey (USGS) Pacific Coastal and Marine Science Center used the USGS Coastal Storm Monitoring System to evaluate the effectiveness of a range of engineered, nature-based and hybrid coastal adaptation strategies in reducing flooding, economic damages,and impacts to the local population in Marina Del Rey and Venice, Calif., USGS.gov
and Frontiers in Marine Science


, NAIROBI, Kenya Apr 22 – The acrimonious relationship between commissioners at the Ethics and Anti-Corruption Commission and secretariat seems to have provided Parliament’s Justice and Legal Affairs committee with sufficient grounds to recommend setting up of a tribunal to look into a petition seeking the removal of Mumo Matemu and Irene Keino from office.
In their report which was submitted to the House on Tuesday, the committee notes that the disharmony and mistrust among commissioners and even the secretariat warrants a new beginning even if it means sending them home.
Nairobi lawyer Oriaro Geoffrey kicked off the process by petitioning the National Assembly with claims that the chairman and the commissioner are in “serious violation of the Constitution, the Ethics and Anti-Corruption Commission Act, the Anti-Corruption and Economic Crimes Act as well as the Penal Code.”
The report which comes up for debate on Wednesday was adopted by a majority – 18 members – with only Ruaraka MP Tom Kajwang’ dissenting.
If the House agrees with the committee recommendations, then President Uhuru Kenyatta will be required to suspend the two pending the outcome of the tribunal which should report on its recommendations within 30 days.
Article 251 of the Constitution states: “A person suspended is entitled to continue to receive one-half of the remuneration and benefits of the office while suspended.”
The tribunal should be headed by a person who is fit to hold the position of a superior court judge, two persons qualified to be appointed as High Court judges and one other member who is qualified to assess the facts in respect of the particular ground for removal.


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The early detection of relapse following primary surgery for non-small-cell lung cancer and the characterization of emerging subclones, which seed metastatic sites, might offer new therapeutic approaches for limiting tumour recurrence. The ability to track the evolutionary dynamics of early-stage lung cancer non-invasively in circulating tumour DNA (ctDNA) has not yet been demonstrated. Here we use a tumour-specific phylogenetic approach to profile the ctDNA of the first 100 TRACERx (Tracking Non-Small-Cell Lung Cancer Evolution Through Therapy (Rx)) study participants, including one patient who was also recruited to the PEACE (Posthumous Evaluation of Advanced Cancer Environment) post-mortem study. We identify independent predictors of ctDNA release and analyse the tumour-volume detection limit. Through blinded profiling of postoperative plasma, we observe evidence of adjuvant chemotherapy resistance and identify patients who are very likely to experience recurrence of their lung cancer. Finally, we show that phylogenetic ctDNA profiling tracks the subclonal nature of lung cancer relapse and metastasis, providing a new approach for ctDNA-driven therapeutic studies.
Trial registration: ClinicalTrials.gov NCT03004755.

domain: health


text:
lower mortgage rates are good news for first-time home buyers and those looking for the best mortgage refinance rates.
Chicago, IL (PRWEB) October 08, 2013
The Federal Savings Bank has been hearing many questions from prospective clients about the effects of the government shutdown on mortgage rates. In the face of a government shutdown, the effect on mortgage rates seems to have been small, as rates have dropped again for the third consecutive week.
According to Fannie Mae and Freddie Mac, interest rates for a 30-year fixed mortgage averaged 4.22 percent for the week ending on Oct. 3. For the previous week, rates were fixed at an average of 4.32 percent.
"With the onset of the federal government shutdown and declining consumer confidence, fixed mortgage rates fell for the third consecutive week," said Frank Nothaft, Freddie Mac's vice president and chief economist.
Lower mortgage rates are good news for first-time home buyers and those looking for the best mortgage refinance rates. However, the drop comes with the possibility that the shutdown will cause a temporary economic downturn.
"Consumer sentiment fell for the second month in a row in September to its lowest reading since April, according to the University of Michigan," stated Nothaft.
"Moreover, a recent Bloomberg survey of professional forecasters suggests that a partial federal shutdown lasting one week would shave 0.1 percentage points off of GDP growth in the fourth quarter and even more if the shutdown lasts longer."
The 30-year rate has reached its lowest level since June 10, 2013. By comparison, last year's rate for the week ending on Oct. 3 was at 3.36 percent, a record low. With uncertainty of where rates will go next, homeowners shouldn't wait to lock in a low rate mortgage.
Bottom line: if you're a buyer, rates are significantly better than last few months. Delaying your purchase risks both higher sales prices and mortgage rates."
Contact The Federal Savings Bank, a veteran owned bank, to discuss affordable mortgage options.


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We expect to have a further update tomorrow.Houston Texans NFL $3B 20.Gerrit Cole, New York Yankees 20.Hinrich hopes to play Tuesday when the Bulls host Phoenix.
3 TBD Highest-Paid Athletes 1.The NBA has established itself as one of the most exciting and innovative sports leagues in the world.Kirk Cousins $60 million $58 million $2 million NFL 10.NBA, Union Extend Deadline To Terminate Collective Bargaining Agreement May 11 11 AM The NBA and NBPA have reached an agreement to extend through the September the 60-day window that preserves the league’s right to terminate the current Collective Bargaining Agreement by use of the force majeure clause.Women’s National Soccer Team, which has qualified to compete in the Summer Olympics in Rio de Janeiro.
– Convention organizers had to address the inevitable: The coronavirus pandemic and subsequent economic turmoil that has dragged down President Donald Trump’s poll numbers all year.Real Madrid soccer $4B 7.When we enter into partnerships with anyone, be it a celebrity, an athlete, it is not something that we take lightly.Overall, he appeared in 21 NHL games, posting six points , 51 penalty minutes and a +9 plus-minus rating.5 ‘Super Bowl LVIII Mercedes-Benz Superdome New Orleans Feb.
With Rogers Place now open, and the surrounding ICE District development well underway, we’re seeing an exciting rebirth of Edmonton’s urban core.Fernando Tatis Jr., San Diego Padres 5.Olympic and Paralympic Teams for the 2014 Winter Games in Sochi, Russia; and for the 2016 Summer Games in Rio de Janeiro, Brazil.Williams won her first three singles matches and first two doubles matches.
27 Tennessee Titans at Green Bay Packers ‘Jan.Carson Wentz $59 million $55 million $4 million NFL Upcoming Super Bowl Games ‘Super Bowl LV Raymond James Stadium Tampa Feb.“I definitely think we’re playing different,” said Keith Van Horn, whose offensive production has picked up considerably the past six games _ five of which came after the Knicks fired Scott Layden and replaced him with Thomas.20 San Francisco 49ers at Dallas Cowboys ‘Dec.’NFL: It was learned Sunday morning that a Patriots player tested positive for COVID-19 during Saturday’s round of testing, which caused their facility to be shut down as a precaution.
Let’s play this game, James concludes.


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Unplugging from the Matrix: 5 Fascinating Facts You Didn’t Know About The Matrix Trilogy
The Matrix trilogy is undoubtedly one of the most influential and beloved film franchises in modern cinema. With its mind-bending storyline, ground breaking visual effects, and philosophical themes, the films continue to captivate audiences to this day. However, beyond what meets the eye on the screen, there are some lesser-known facts about “The Matrix” trilogy that may surprise even its most dedicated fans. Here are 5 fascinating facts you may not have known about The Matrix trilogy!!
The Wachowski Siblings’ Unique Vision:
The Wachowski siblings, Lana and Lilly, who wrote and directed the entire Matrix trilogy, had a unique vision for the films. They drew inspiration from various sources, including philosophy, mythology, and anime. The iconic “bullet time” effect, which became synonymous with the series, was inspired by the 1960s Japanese anime series “Ghost in the Shell.” The Wachowskis’ bold and innovative approach to storytelling and visual effects set “The Matrix” trilogy apart as a visionary film franchise.
The Actors’ Dedicated Training:
The actors in The Matrix trilogy underwent extensive training to bring the film’s intricate action sequences to life. Keanu Reeves, who portrayed Neo, spent months training in various martial arts, including kung fu and karate, to master the demanding fight scenes. Carrie-Anne Moss, who played Trinity, also underwent intensive martial arts training to convincingly portray the formidable and agile character. The dedication and physical training of the cast added an extra layer of authenticity and realism to the film’s action sequences.
The Iconic Costumes:
The iconic black leather costumes worn by the characters in The Matrix trilogy have become synonymous with the film’s aesthetic. However, the costumes were not just for fashion; they were carefully designed to reflect the characters’ identities and roles within the story. The characters’ black leather outfits were meant to symbolise their rebellion against the machine-controlled world of the Matrix, while also evoking a sense of sleekness and power. The costumes, designed by renowned costume designer Kym Barrett, have become iconic in pop culture and have influenced fashion trends in the years following the film’s release.
The Philosophy Behind the Story:
The Matrix trilogy is known for its deep philosophical themes that explore the nature of reality, existence, and freedom. The films draw inspiration from various philosophical concepts, including Plato’s Allegory of the Cave and Descartes’ Meditations on First Philosophy. The Wachowskis used these philosophical ideas to craft a thought-provoking narrative that challenges the audience’s perceptions of reality and identity. The films’ blend of high-concept science fiction and philosophical musings has sparked countless debates and discussions among fans and scholars alike.
In conclusion, The Matrix trilogy is not just a series of visually stunning and action-packed films, but also a rich tapestry of philosophical concepts, innovative storytelling, and meticulous attention to detail. From the Wachowski siblings’ unique vision to the actors’ dedicated training, the iconic costumes.
If you would like to become a partner with us and have access to our extensive licenced portfolio, please email us at:


5 Tips about ansys fluent project help You Can Use Today
The point that Younger modulus is associated with density like E=f(d)*E0 (exactly where E0 may be the Young modulus to the sound material, d may be the relative density and f(d) a functionality that depend upon the density plus the geometry on the infill) could help to lessen the volume of experiments?
The purpose of the simulation is to determine the minimal necessary WATER MASS FLOW Amount within the shell inlet to boost the normal outlet temperature of the oil flowing with the tube to much more than 307.
Are there a couple of parameters that characterize all four components, such as density and Younger's Modulus? If that is so, you can have only one product and also a parameter research that has four rows containing the values that signify Every on the 4 components.
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To operate the ansys workbench, load the module and run runwb2. Since the workbench is major graphics, we'd advocate you operate it within a VNC session. See FarmVNC. If you want accelerated 3D graphics, you may run comparable to the instance right here: smokeParticles on Rye.
Each individual case includes its have documentation describing the experimental setup to which it was when compared along with the relative precision on the simulation end result. To the ideal of our awareness, STAR-CCM+ is the sole multiphysics simulation Instrument that has realized ASME Nuclear Excellent Assurance – one compliance.


Double girder overhead crane is a type of crane that features two parallel girders as the main load-bearing components. It is commonly used in industrial environments, construction sites, manufacturing facilities, and other locations where heavy loads need to be lifted and moved.
Overhead Bridge Crane
|Double Girder Overhead Crane
|After-sales service provided
|Video Technical Support
|Max. lifting load
- Double Girder Design: The crane features two parallel horizontal girders that span the width of the working area. The girders are typically I-beam or box beam structures that provide support for the hoisting mechanism and allow for the movement of the trolley along the length of the crane.
- Increased Lifting Capacity: Double girder overhead cranes are designed to handle heavier loads compared to single girder cranes. The double girder configuration provides increased strength and stability, allowing for higher lifting capacities.
- Electrically Powered: Double girder overhead cranes are powered by electrical energy and operate using electric motors. Electric power provides smooth and precise control over crane movements, including lifting, trolley travel, and bridge travel.
- End Trucks: The girders are supported by end trucks on either side, which consist of wheels or casters that run along overhead runways or tracks. The end trucks provide stability and enable the crane to move horizontally along the length of the working area.
- Hoisting Mechanism: The hoisting mechanism is mounted on the trolley, which travels along the girders. It consists of an electric motor, drum, and wire rope or chain. The hoisting mechanism allows for the lifting and lowering of loads.
- Trolley: The trolley is a mechanism that moves horizontally along the girders. It carries the hoisting mechanism and allows for the precise positioning of the load along the length of the crane.
- Control System: Double girder overhead cranes are operated using a control panel or pendant station, allowing the operator to control the crane's movements, including lifting, lowering, trolley travel, and bridge travel.
- Safety Features: Double girder overhead cranes incorporate various safety features such as overload protection, emergency stop buttons, limit switches, and safety interlocks. These features ensure safe operation and prevent accidents.
Support and Services:
The technical support and service for Overhead Bridge Crane includes:
- 24/7 customer support
- Remote service and troubleshooting
- Manufacturer's warranty
- On-site service and repair
- Emergency service
- Preventive maintenance contracts
- Replacement part sales
- Training services
- Consulting services
Packing and Shipping:


The tech giants continued to get hammered today. We’ve talked about the prospects for an unraveling of the tech giants for much of the past year.
Despite the clear warning shots that were fired by regulators/lawmakers (and the President) along the way, these stocks kept going up — until they didn’t.
As I said back on September 4th, when Amazon crossed the trillion-dollar valuation threshold, “at 161 times earnings, the market seems to be betting on the Amazon monopoly being left to corner all of the world’s industries. That’s a bad bet. Much like China undercut the compeition on price and cornered the world’s export market, Amazon has undercut the retail industry on price, and cornered the world’s retail business. That tipping point (on retail) has well passed. And as sales growth accelerates for Amazon, so does the speed at which competition is being destroyed. But Amazon is now moving aggressively into almost every industry. This company has to be/will be broken up.”
A day later, Facebook and Twitter executives visited Capitol Hill for a Congressional grilling. Here’s an excerpt from my note that day: “If you listened to Zuckerberg‘s Congressional testimony in April, and today’s grilling of Jack Dorsey (Twitter) and Sheryl Sandberg (Facebook), it’s clear that they have created monsters that they can’t manage. These tech giants have gotten too big, too powerful and too dangerous to the economy (and society).”
Here we are, a little more than two months later, and the sentiment on tech has dramatically changed. Amazon topped the day it reached the trillion-dollar valuation and has lost a quarter of a trillion dollars in value since (down 26%). Facebook is down 39% since the record highs in July.
So it appears that we are finally seeing the “monopoly scenario” priced out of the tech giants. And with that, we should see money moving back into those stocks that have been left for dead in industries like media, retail, shipping (to name a few). This is the Dow/Nasdaq convergence we’ve been looking for for much of this year — and we’re getting it. At one point this summer the Nasdaq was up close to 15% on the year, while the Dow was flat. Now both are up just over 1% year-to-date. I suspect that Dow outperformance will continue.
We have G20 tomorrow, where the world will be watching for some movement on the U.S./China trade negotiations. Any hint at a deal should get this Dow trade moving aggressively higher.


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ÖBB will introduce capsule carriages
Austrian Federal Railways (ÖBB) intends to introduce the next generation of sleeping carriages. Instead of conventional compartments, they have capsules for private accommodation of passengers. The new coaches will be entered service starting from 2022.
ÖBB will use the capsule carriages for its Nightjet trains. They were developed taking into account customer feedback. Three years ago, the company has demonstrated the mockups of compartments at Vienna Main station. Last week, ÖBB has unveiled the final digital design of the coaches. In 2022, the passengers will be able to use the innovative carriages manufactured by Siemens Mobility. They will form 13 seven-car Nightjet trainsets.
The key feature of the new sleeping carriages is the accommodation of passengers in capsules known as MiniSuites instead of ordinary compartments. Each capsule has sliding doors to provide a high level of privacy. It is also equipped with a monitor, reading lamp, charging facilities, coat hook and a pocket for storing personal belongings to offer a comfortable trip.
There are four capsules per each compartment located on two floors, each floor has a folding table. The capsules on the same floor could be paired by opening a sliding roller at the head. Each compartment has a special area to store outer clothing and baggage. Besides the four-berth compartments, ÖBB has shown the two-berth non-capsule ones. They will provide higher service for passengers.
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