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| Abstract|| |
Background: Circulating tumor cells (CTCs) are cells present in the blood stream that are antigenically or genetically similar to a specific tumor type and are markers of tumor diagnosis, prognosis, residual disease and metastasis. The ever-increasing burden of breast cancer globally warrants the incorporation of this all-inclusive marker in the diagnostic repertoire using the simplest of techniques. Aims: To identify CTCs in peripheral blood by cell block (CB) technique in cases of breast cancer diagnosed on fine-needle aspiration (FNA) or core needle biopsy (CNB) and to correlate their presence with nodal metastasis. Material and Methods: This study was conducted in the Department of Pathology, at a tertiary care hospital. Peripheral blood samples from a total of 30 cases of primary breast carcinoma diagnosed on FNA or CNB without prior neoadjuvant chemotherapy were analyzed using the CB technique. Results: The age ranged between 29-74 years with the most common presenting complaint being a palpable, single, unilateral breast lump. CTCs were detected in 2 (6.7%) cases with a <5 cell cluster with both the cases being grade I breast carcinomas and also displaying nodal metastasis.
Keywords: Breast carcinoma, cell block (CB), circulating tumor cells (CTCs), core needle biopsy (CNB), fine-needle aspiration (FNA)
|How to cite this article:|
Agrawal N, Punia RS, Handa U, Attri AK. Isolation and morphology of circulating tumor cells by cell block technique in breast cancer. Indian J Pathol Microbiol 2021;64:329-33
|How to cite this URL:|
Agrawal N, Punia RS, Handa U, Attri AK. Isolation and morphology of circulating tumor cells by cell block technique in breast cancer. Indian J Pathol Microbiol [serial online] 2021 [cited 2021 May 8];64:329-33. Available from: https://www.ijpmonline.org/text.asp?2021/64/2/329/313263
| Introduction|| |
Cancers prove to be the second leading cause of deaths globally with an estimated 18.1 million new cases and 9.6 million cancer deaths worldwide in 2018. Out of all the carcinomas breast cancer is of paramount importance with Northern America, Western and Northern Europe and Australia having the highest incidence with a range of 85.8 to 96.0 per 100,000 women. Amongst the Indian population, the age adjusted incidence rate of breast cancer is 25.8 with a mortality of 12.7 per 100,000 women. Diagnosis of breast cancer cases follows a multi-pronged approach with the amalgamation of clinical examination, radiological examination using mammography and BI-RADS scoring system, cytopathological and histopathological evaluation for utmost sensitivity and specificity. Cytopathological examination incorporates FNAC and nipple discharge smears with a sensitivity and specificity of 74% and 96% respectively. The histopathological examination can be carried out on CNB with sensitivity and specificity of 87% and 98%, respectively. The most frightening prospect after diagnosis of breast carcinoma is the possibility of metastasis which can even develop several years after the diagnosis of primary tumor and herein lays the import of liquid biopsy in the form of CTCs.
CTCs are a heterogeneous group of cells with this diversification being attributed to two factors i.e., cancer stem cells and epithelial-to-mesenchymal transition. An assortment of tests and techniques have been developed based on the physical, biological and immunomagnetic properties for the enumeration and enrichment of CTCs, where enumeration stands for the total number of cells and enrichment for the isolation and extraction of cells from the blood stream. However, these technologies require an exorbitant capital and substantial resources which hinders their widespread use especially in a resource poor country like India.
To overcome this impediment, we have utilized the technique of CB, which is a routine practice in cytopathology wherein, the material obtained from cytological specimen, whether in the form of sediment, blood clot or tissue pieces, is processed similar to histopathology.
| Materials and Methods|| |
This prospective study was conducted at our tertiary care hospital from December 2017 to October 2019. It included 30 cases diagnosed as primary breast carcinoma, irrespective of age, on FNAC and CNB without prior neoadjuvant chemotherapy and about to undergo modified radical mastectomy (MRM). Ethical clearance was obtained from the Institutional Ethics Committee. This study was approved by the GMCH Chandigarh Institutional Ethics Committee on 8th December 2017. IEC Regd no. ECR/658/Inst/PB/2014. Complete clinico-radiological investigations and prior FNAC or CNB findings were recorded for each patient. 7.5-10 mL of venous blood was withdrawn, preferably from the median cubital vein, under aseptic conditions from the patient one day before she underwent MRM in sterile glass bottles which were kept in the biosafety cabinet.
Cell block processing
The blood was allowed to self-clot. After the clotting process was complete 10% neutral buffered formalin was poured in the bottle and it was made to stand overnight. The supernatant was poured off and the sediments were picked up by spatula, wrapped in tissue paper and placed in a tissue cassette. Rest of the processing was similar to routine paraffin embedding technique for any other tissue. Multiple sections were cut at 3 μm and the cell blocks were exhausted to search for CTCs and stained by hematoxylin and eosin (H & E). The CTCs were searched for under high power magnification (40×) and also under oil immersion (100×). The slides were examined by two pathologists blinded to each other's findings.
Criteria for a cell to qualify as a CTC on H and E stain: A cell size larger than the sizes of normal blood cellular components along with a visible nucleus. The slides were classified as being positive or negative for the presence of CTC and a cut-off value of ≥1 CTC was considered positive.
Processing of MRM specimen
After the MRM specimen had been received in histopathology in 10% neutral buffered formalin, it was grossed according to the standard protocols. The MRM specimen was kept for overnight fixation after making serial sections in the tissue perpendicular to the attached elliptical skin flap. The relevant measurements were noted and location of tumor was identified. Sections were taken from the tumor proper, fibrotic areas, surgical margins and nipple areola complex. Lymph nodes were searched for in the axillary tail and a minimum of 10 lymph nodes were isolated. The lymph nodes with size <0.5 cm were embedded as such, while those ≥0.5 cm were bisected and embedded. These sections were processed routinely with paraffin embedding technique. Sections of 3 μm thickness were cut and stained by H and E stain. Immnohistochemistry (IHC) staining with CK was applied in lymph nodes showing presence of metastatic tumor deposits wherever required.
Categorical variables were reported as counts and percentages. Group comparisons were made with the Chi-Square test or Fisher's exact test as appropriate. Continuous data were given as Mean/SD and range or median and inter-quartile range as appropriate. Spearman correlation coefficient was calculated to see relation between variables. A P value <0.05 was considered significant. Analysis was conducted using IBM SPSS STATISTICS (version 22.0).
| Results|| |
All the patients were females with the average age range between 29 to 74 years and a mean of 54.03 ± 10.65 years. All the patients presented with palpable breast lumps which were single and unilateral. The lump was right sided in 19 (63.3%) patients and left sided in 11 (36.7%) patients. The duration of the lump varied from 1 month to 2 years with a mean of 7.03 ± 6.86 months. In 13 (43.3%) cases lump was located in central quadrant, 11 (36.7%) cases in upper outer quadrant, 4 (13.3%) cases in upper inner quadrant and 1 (3.3%) case each in lower outer and lower inner quadrants. The minimum lump size on mammography was 1 cm while the maximum size was 6 cm with a mean of 2.98 ± 1.2 cm and median of 3.05 cm. Maximum i.e., 12 (40%) cases had a BI-RADS score V in the involved breast while only 2 (6.7%) cases had a BI-RADS score III.
Out of all the 30 cases, both FNAC and CNB had been performed in 4 (13.3%) cases, only FNAC in 17 (56.7%) cases and only CNB in rest of the 9 (30%) cases. Out of the 21 (70%) cases on whom FNAC was performed, a maximum of 16 (76.1%) cases were diagnosed as IDC, 2 (9.5%) cases as suggestive of IDC and 1 (4.8%) case each as suspicious of IDC, poorly differentiated malignant tumor and mucinous carcinoma. FNAC displayed a 100% sensitivity and specificity in our study. Out of the 13 (43.3%) cases on whom CNB was performed, a maximum of 9 (69.2%) cases were diagnosed as IDC, 1 (7.7%) case each of IDC with medullary features and infiltrating carcinoma likely lobular while in 2 (15.4%) cases no definitive diagnosis was possible. CNB displayed a sensitivity of 84.6% and a specificity of 100%.
Multiple sections were obtained from the CB prepared from peripheral blood and a total of 2 (6.7%) cases out of all the 30 cases included in this study showed presence of CTCs. In both the cases the CTCs were present in clusters of <5 cells. The cells displayed moderate pleomorphism with vesicular nuclear chromatin, prominent nucleoli and mild to moderate amount of cytoplasm [Figure 1]a and [Figure 1]b.
|Figure 1: (a and b): Photomicrographs showing a cluster of tumor cells in a section from peripheral blood cell block (H&E, ×400)|
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In the MRM specimens out of all the cases, 27 (90%) cases were diagnosed as IDC, NOS, and 1 (3.3%) case each of IDC with medullary features, IDC with mucinous features and medullary carcinoma. Using the Modified Scarff-Bloom Richardson Grading out of all the 27 cases of IDC, NOS 21 (77.8%) cases were classified as grade II. IDC with medullary features and medullary carcinoma were classified as grade III while IDC with mucinous features was classified as grade I. A minimum of 10 lymph nodes were isolated in all the cases with a maximum of 27 lymph nodes in 2 (6.7%) cases. The mean number of lymph nodes isolated was found to be 16 ± 5.32. 17 (56.7%) cases showed presence of nodal metastasis.
In the present study, both the cases with positive CTCs had a histopathological tumor grade I with one case being IDC, NOS, and other being IDC with mucinous features [Table 1] and [Table 2]. On statistical analysis using Chi square test, it was found to be significant with a P value of <0.001. Lymph node metastasis was noted in both the cases showing presence of CTCs. In addition, lymph node metastasis [Table 3], percentage of metastatic deposits and LVI were compared with the CTCs in peripheral blood however, no association was found between them as the P value was >0.05 in each of these correlations.
|Table 1: Correlation of circulating tumor cells (CTCs) with the histopathological grade of tumor (n = 30)|
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|Table 2: Correlation of circulating tumor cells (CTCs) with the type of tumor (n = 30)|
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|Table 3: Correlation of circulating tumor cells (CTCs) with lymph node metastasis (n = 30)|
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| Discussion|| |
Breast cancer is one of the most commonly encountered tumors and is well known for its notorious clinical behavior leading to substantial mortality and morbidity globally. This in large part can be allocated to the phenomenon of metastasis. The clinical diagnosis of breast cancer, in most of the developing countries, is still dependent on the triple testing which includes palpation of breast lump, radiological findings and tumor detection using histopathological techniques like FNAC or CNB. The mean age of patients with breast cancer in this study was 54.03 ± 10.65 years which are in concordance with the results of survey carried out by Indian Council of Medical Research (ICMR) published by Malvia et al. It was found that breast cancer occurs one decade earlier in Indian women as compared to western population with a peak between 40-50 years. All the patients presented with a palpable unilateral breast lump which in most cases i.e., 19 (63.3%) were right sided. These findings are mostly similar to those obtained by Takalkar el al. however; left-sided breast lump (50.7%) were more frequent in their study.
In our study 23 (76.7%) cases had a BIRADS score of IV-V with only 2 (6.7%) cases having a BIRADS score III. BN et al. have reported similar findings with most of the malignant breast lesions belonging to BIRADS categories IV and V. A sensitivity and specificity of 100% for FNAC was noted in our study which is equivalent to the results obtained by BN et al. A sensitivity of 84.6% and specificity of 100% was displayed by CNB in the present study which is in concordance with Saha et al. who found the sensitivity and specificity of CNB to be 88.3% and 100%, respectively.
CTCs are referred to whole tumor cells which are either present singly or in clusters in the blood stream and are released directly by the main tumor or from the metastatic sites. They can also be defined as non-leucocytic cells which are usually 20-30 μm in size with variable morphological aspects depending on the primary tumor., The growing emphasis on CTCs stems from the fact that it is a valuable prognostic marker at every stage of breast cancer including prevention in an at-risk population, early detection, minimum residual disease after a resected tumor, harbingers of metastasis and monitoring for cancer recurrence in a clinically treated patient. It also pitches in as a predictive marker by guiding treatment therapies in resistant cancers. Cristofanilli et al. have demonstrated a direct correlation between the absolute number of CTCs in 7.5 mL of peripheral blood with overall survival and progression free survival. Owing to its import as an all-inclusive marker emphasis has been on evolution and elaboration of CTC detection techniques. The various distinct biophysical and immunological properties are utilized for this purpose. The differences in cell size and density are exploited in physical filter, density gradient, photoacoustic and microfluidic devices along with morphology-based imaging cytometry. Techniques based on antibody capture incorporate CellSearch and Magsweeper with functional characteristics being utilized in Epispot assay and invasion assay. Nanotechnology is the latest methodology to join this long list of existing techniques., All of them show variable sensitivity and specificity for the detection of CTCs, however, CellSearch is the only FDA cleared technology for the detection of CTCs currently wherein the CTCs are captured using ferrofluids tagged with EpCAM antibody. In a study conducted by Pierga et al. out of the total 97 patients without neoadjuvant chemotherapy 22 (23%) cases showed presence of at least 1 CTC. Several studies have contrasted the efficacy of different assays in isolation of CTCs with that of CellSearch; however, the CB method has not been utilized for this purpose. A study was conducted by Nam et al. to detect CTCs in patients of liver cancer using CB method. Out of the 29 patients included in their study CTCs were detected in 14 (48.3%) cases whereas, in our study, using the CB technique, CTCs were isolated in 2 (6.7%) cases out of the total 30 cases. CB is a long-established universal technique in cytopathology having better results in terms of cellular yield as compared to conventional smears with a sensitivity and specificity of around 92% and 99%, respectively. Herein, the material obtained whether in the form of sediment, blood clot, or tissue pieces is processed similar to histopathology with creation of paraffin blocks. However, CTC being a scarce and rare event in the peripheral blood with a half-life of few minutes to few hours could conceivably be difficult to detect using this methodology. CB although being the least technically challenging of all and offering the advantage of several sections for the examination of CTCs may lead to loss of single tumor cells during section cutting.
Also, in the present study nodal metastasis was demonstrated in a total of 17 (56.7%) cases. These findings are consistent with those of Pathak et al. with 66.1% cases demonstrating nodal metastasis. In our study, CTCs were detected in both the histopathological grade I tumors and this finding was statistically significant. However, none of the cases in grade II or III showed presence of CTCs in the CB preparation. These findings are at variance with those of Bansal et al. where the highest CTC positivity was seen in Grade III tumors (31.25%) followed by grade II (1.31%) and then grade I (0%). Both the CTC positive cases, in our study, displayed presence of metastatic deposits in the axillary lymph nodes; however, this finding was not significant statistically. On the contrary, Nakagawa et al. have demonstrated a statistically significant correlation between these variables with a directly proportional relationship between number of metastatic lymph nodes and CTC detection. The findings of the above-mentioned study is reproduced by Bansal et al. with 81.82% CTC positive cases having nodal metastasis. An association between presence of CTCs and LVI was also elucidated in our study but it was non-significant. Similar findings have been described by Biggers et al. with 41.4% cases displaying positive CTCs in the absence of LVI.
A few shortcomings of our study include identification of only a small cluster of CTCs which was not present on the subsequent sections, thwarting the use of IHC. Similarly, we may have missed single tumor cells during technical processing and in the absence of IHC leading to lack of identification of tumor cells in grade II and III tumors.
Take home message
CTCs have proved their mettle as a stellar prognostic and predictive marker with a variety of exemplary studies authenticating its import. Cytopathological techniques primarily cell block can be availed for the purpose of detecting these CTCs, our study being a small step in that direction. However, further studies are recommended for the corroboration of our findings.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
| References|| |
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2018;68:394-424.
Malvia S, Bagadi SA, Dubey US, Saxena S. Epidemiology of breast cancer in Indian women. Asia Pac J Clin Oncol 2017;13:289-95.
Wang M, He X, Chang Y, Sun G, Thabane L. A sensitivity and specificity comparison of fine needle aspiration cytology and core needle biopsy in evaluation of suspicious breast lesions: A systematic review and meta-analysis. Breast 2017;31:157-66.
Kamal M, Razaq W, Leslie M, Adhikari S, Tanaka T. Circulating tumor cells in breast cancer: A potential liquid biopsy. In: Pham PV, editor. Breast Cancer-from Biology to Medicine. 1st
ed. Croatia: InTech; 2017: p. 119-45.
Jain D, Mathur SR, Iyer VK. Cell blocks in cytopathology: A review of preparative methods, utility in diagnosis and role in ancillary studies. Cytopathology 2014;25:356-71.
Takalkar UV, Asegaonkar SB, Kulkarni U, Saraf M, Advani S. Clinicopathological profile of breast cancer patients at a tertiary care hospital in marathwada region of western India. Asian Pac J Cancer Prev 2016;17:2195-8.
Navya BN, Thomas S, Hiremath R, Alva S. Comparison of diagnostic accuracy of BIRADS score with pathologic findings in breast lumps. Annals Pathol Lab Med 2017;4:236-42.
Saha A, Mukhopadhyay M, Das C, Sarkar K, Saha AK, Sarkar DK. FNAC versus core needle biopsy: A comparative study in evaluation of palpable breast lump. J Clin Diagn Res 2016;10:5-8.
Ghosh RK, Pandey T, Dey P. Liquid biopsy: A new avenue in pathology. Cytopathology 2019;30:138-43.
Palmirotta R, Lovero D, Cafforio P, Felici C, Mannavola F, Pellè E, et al
. Liquid biopsy of cancer: A multimodal diagnostic tool in clinical oncology. Ther Adv Med Oncol 2018;10:1-24.
Pantel K, Speicher MR. The biology of circulating tumor cells. Oncogene 2016;35:1216-24.
Cristofanilli M, Hayes DF, Budd GT, Ellis MJ, Stopeck A, Reuben JM, et al
. Circulating tumor cells: A novel prognostic factor for newly diagnosed metastatic breast cancer. J Clin Oncol 2005;23:1420-30.
Pierga JY, Bidard FC, Mathiot C, Brain E, Delaloge S, Giachetti S, et al
. Circulating tumor cell detection predicts early metastatic relapse after neoadjuvant chemotherapy in large operable and locally advanced breast cancer in a phase II randomized trial. Clin Cancer Res 2008;14:7004-10.
Nam SJ, Yeo HY, Chang HJ, Kim BH, Hong EK, Park JW. A new cell block method for multiple immunohistochemical analysis of circulating tumor cells in patients with liver cancer. Cancer Res Treat 2016;48:1229-42.
Matreja SS, Malukani K, Nandedkar SS, Varma AV, Saxena A, Ajmera A. Comparison of efficacy of cell block versus conventional smear study in exudative fluids. Niger Postgrad Med J 2017;24:245-9.
] [Full text]
Pathak R, Jha A, Neupane P, Chalise S, Basnyat A. Histopathological evaluation of carcinoma of breast. J Pathol Nepal 2016;6:922-7.
Bansal C, Pujani M, Misra S, Srivastava AN, Singh US. Circulating tumor cells in breast cancer: Correlation with clinicopathological parameters, hormone profile and microRNA polymorphisms. Turk Patoloji Derg 2016;32:148-57.
Nakagawa T, Martinez SR, Goto Y, Koyanagi K, Kitago M, Shingai T, et al
. Detection of circulating tumor cells in early-stage breast cancer metastasis to axillary lymph nodes. Clin Cancer Res 2007;13:4105-10.
Biggers B, Knox S, Grant M, Kuhn J, Nemunatitis J, Fisher T, et al
. Circulating tumor cells in patients undergoing surgery for primary breast cancer: Preliminary results of a pilot study. Ann Surg Oncol 2009;16:969-71.
P-2, Police Officer's Colony, Sector-2, Panchkula, Haryana - 134 112, Chandigarh
Source of Support: None, Conflict of Interest: None
[Table 1], [Table 2], [Table 3]


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One small sip for “S3” was one miraculous leap for neurotechnology. According to a recent report in Nature, a 58-year-old woman with long-standing tetraplegia (named “S3” in the report) mobilized a free-standing robotic arm to reach out and grasp a cup of coffee—a highly complex fine-motor movement—with merely her thoughts.1
Five years before this awe-inspiring moment, a tiny neural implant (called BrainGate) with 96 electrodes was implanted in S3’s motor cortex. BrainGate’s sensor recorded the electrical activity of an array of motor neurons triggered when S3 imagined specific reach and grasp movements; these patterns of motor signals were “translated” (digitalized) into a series of zeros and ones that instructed a computer to operate an independent robotic (mechanical) arm with 3-dimensional movements. With a neural-computer interface, S3 could grasp a cup of cof-fee with brain signals alone. Remarkably, the motor cortex’s firing pattern—the sequence of zeros and ones—that had been recorded 5 years earlier remained essentially unchanged. S3 had a brain-computer interface to thank for restoring volitional movements to her paralyzed limb. Such an achievement is just one of many notable stories unfolding in the emerging field of neurotechnology.
Neurotechnology refers to the science of applying our emerging understanding of the brain, consciousness, thought, and higher-order activities of the mind into developing technologies. The tools of neurotechnology, however, are not new for psychiatrists. For example, in the realm of diagnostic imaging, functional MRI (fMRI) scanning discoveries have linked the brain’s anatomy with localized emotional and cognitive functions and dysfunctions.
One groundbreaking finding was Area 25 that Helen S. Mayberg, MD, identified as a “nerve center” for depression; it may be a reliable barometer for antidepressant treatment as well.2 Moreover, modern electro- and magneto-encephalography can detect tumors, find stroke sites, and specify epilepsy-prone brain areas. Other advances in neuroimaging promise to identify dysfunctional neural circuits associated with human psychopathology and suffering.
Beyond diagnostics, neurotechnologies are used in psychiatric treatment. The electromagnetic “wand” used in repetitive transcranial magnetic stimulation (rTMS) is FDA-approved for the treatment of depression, and emerging research indicates that rTMS could help less-en the intrusive thoughts of obsessive-compulsive disorder, improve the painful apathy associated with certain psychotic disorders, and diminish chronic pain caused by migraine headaches and phantom limb syndrome.
Neural implants, including computer chips and optic probes, are already in use to treat epilepsy and Parkinson disease. Similarly, research is under way to use deep brain stimulators to treat obsessive-compulsive disorder, refractory depression, Tourette syndrome, and addictions and to curb appetite and reduce obesity. Advanced drug delivery systems are being designed to zero in on diseased brain sites or turn on genes that could promote cell growth—and to do so without the degree of collateral damage associated with less precise methods.
Smart drugs, “nootropics,” that selectively boost the functioning of neural circuits involved in memory and cognition are another budding frontier. Perhaps the most incredible application is the field of optogenetics, where specially engineered, light-activated (or light-inactivated) ion channels are implanted in the brain to curtain the firing of neurons associated with anxiety or trauma. Native to unicellular algae found in a pond, these implantable ion channels—such as blue-light–activated channelrhodopsin that promotes neuronal firing or yellow-light–activated halorhodopsin that actually silences a neuron—can now assist neuroscientists in disentangling complicated neural circuits and, perhaps, in identifying an anxiety gene that could be targeted with gene therapy. This work is under way with mice, a few cortical steps away from man.3
1. Hochberg LR, Bacher D, Jarosiewicz B, et al. Reach and grasp by people with tetraplegia using a neurally controlled robotic arm. Nature. 2012;485:372-375.
2. Mayberg HS, Lozano AM, Voon V, et al. Deep brain stimulation for treatment-resistant depression. Neuron. 2005;45:651-660.
3. Schoonover CE, Rabinowitz A. Control desk for the neural switchboard. New York Times. May 16, 2011. http://www.nytimes.com/2011/05/17/science/17optics.html?pagewanted=all&_r=0. Accessed October 4, 2012.

domain: medical


Tony Bennett: Class Act
Broadcast: July 30, 2023 at 4:00 p.m.
Listen to this episode: Click here.
Music highlights from the remarkable career of one of the most revered pop singers in American history, Tony Bennett, who passed away July 21, 2023 at the age of 96.
Music history specials producer Paul Ingles hosts an hour of nearly 20 of Bennett's classic performances


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When the newly crowned Queen Elsa accidentally uses her power to turn things into ice to curse her home in infinite winter, her sister Anna teams up with a mountain man, his playful reindeer, and a snowman to change the weather condition.
The Incredibles hero family takes on a new mission, which involves a change in family roles: Bob Parr (Mr Incredible) must manage the house while his wife Helen (Elastigirl) goes out to save the world.
Craig T. Nelson,
Maleficent and her goddaughter Aurora begin to question the complex family ties that bind them as they are pulled in different directions by impending nuptials, unexpected allies and dark new forces at play.
The magically long-haired Rapunzel has spent her entire life in a tower, but now that a runaway thief has stumbled upon her, she is about to discover the world for the first time, and who she really is.
In Africa, the lion cub Simba is the pride and joy of his parents King Mufasa and Queen Sarabi. Mufasa prepares Simba to be the next king of the jungle. However, the naive Simba believes in his envious uncle Scar that wants to kill Mufasa and Simba to become the next king. He lures Simba and his friend Nala to go to a forbidden place and they are attacked by hyenas but they are rescued by Mufasa. Then Scar plots another scheme to kill Mufasa and Simba but the cub escapes alive and leaves the kingdom believing he was responsible for the death of his father. Now Scar becomes the king supported by the evil hyenas while Simba grows in a distant land. Sometime later, Nala meets Simba and tells that the kingdom has become a creepy wasteland. What will Simba do?Written by
Claudio Carvalho, Rio de Janeiro, Brazil
Galagos (bushbabies) are strictly nocturnal in real life, but here are seen frolicking with Timon and Pumbaa in broad daylight. See more »
Life's - not fair - is it, my little friend? While some are born to feast - others spend their lives in the dark... begging for scraps. The way I see it, you and I are exactly the same, we both want to find a way out.
See more »

domain: artistic


text:
Scientist Arthur Middleton, photographer Joe Riis, artist James Prosek and filmmaker Jenny Nichols join forces in this documentary that captures the migration of elk in the Yellowstone area through a multidisciplinary lens. For many of the elk herds that summer in Yellowstone National Park, home is outside the protected park boundaries the rest of the year, as far as 70 miles away. Mirroring a similar expedition undertaken in 1871 that fused science and the arts, this modern band of explorers join their ungulate counterparts on a trek from Wyoming’s rangeland through snowy mountain passes and treacherous river crossings to the rugged beauty of Yellowstone’s high-alpine meadows. Along the way, they meet backcountry guides and cattle ranchers whose lives are intricately tied with the fate of the elk and other migratory species that call the Greater Yellowstone Ecosystem home.
Editor: Jenny Nichols
Cinematography: Joe Riis, Jenny Nichols, Shane Moore, Skip Armstrong
Music: “Never stop dreaming” by Cleod9, Created by Ian McLeod
Funded by: George B. Storer Foundation, Bole & Klingenstein Foundation, National Geographic Society
Across Africa today wildlife is disappearing, and its story is grim. Yet there is one powerfully bright spot – Namibia - where its people have made the commitment to live with and protect their wildlife.
The Guardians tells the story of Jantjie Rhyn, a farmer from one of Namibia’s vibrant communal conservancies. Despite the dangers of living with lions and other free-roaming wildlife, Jantjie and his community are committed to their protection because responsible tourism and national pride make his wildlife worth more alive than dead. He represents one in five Namibians that today are directly involved in conservation, making him a true guardian of Africa’s natural legacy. Namibians like Jantjie are showing the world how to improve wildlife and a community's lives all at once.
Namibia is home to the greatest wildlife recovery story ever told. Since its birth just over 2 decades ago, the country of Namibia has shown the world how to ensure Africa’s natural legacy while expanding livelihoods. Pride of Namibia tells the story of communities committed to protecting wildlife, of a nation that has enshrined conservation into its constitution, and of the future of responsible travel - tourism that directly benefits the people who give wildlife freedom to roam.

domain: geography


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Sports journalists writes and reports on amateur and professional sports. As a sports journalist myself, I know you can presume a variety of job duties such as reporting game statistics, interviewing coaches, players and running commentaries on games as well. You can equally work in a variety of media outlets including Radio, Television, Print and the new media [Social Media].
Such a noble profession which most of us craved in our youthful days has now become a subject of radical because some Sports journalists in Ghana Today have become political stewards seeking to run their private businesses through Sport thereby polluting and destroying the values and reputation of Sports in Ghana.
The likes of Christopher Opoku and Aminu Zylla of blessed memory (May their souls rest in prefect peace), Kwabena Yeboah and Owusu Bempah have made meaningful contributions to the Sports fraternity in the country which we can all attest to. They exhibited the highest level of professionalism in their career as Sports Journalist.
According to the Ghana statistical service, the average literacy rate in the country stands at 58% which means that 48% of the Ghanaian public are illiterates and they rely on the Sports Journalists as a reference point and believes in whatever he communicates on the various media platforms available. We are the major source of information and educators to a lot of people who love Sports and desire to know more about it. No wonder a cross section of the Ghanaian public subscribe to our opinions as fact whenever there is an issue. For that matter, our opinions and submissions must be based on fact and not thought.
After Anas Aremayaw Anas premiered his Number 12 Expose, the attitude, posture and comments of most Sports Journalist in the country during the first two months has turned dark light on Sports in Ghana.
The popular song in town then was “Government should dissolve the Ghana Football Association (GFA)” which the larger Ghana community both home and abroad fell for.
FIFA later served the country a letter and stated the consequences of the dissolution in plain language after the government took steps to dissolve GFA.
Notable among the repercussions are; Ghana would be banned from all FIFA organized competitions including AFCON tourneys, FIFA World Cup’s and couple of others.
Today most of these Sports Journalists are advocating that government should now use other means to enable our beloved country Ghana escape the wrath of FIFA. I seek to ask why we did not preach that from the onset.
One thing I have observed is that, our hate for someone affects our sense of judgment on issues most times, which is very wrong for us as journalist. It is bad to criticize characters because we hate them, let’s criticize institutions instead of attacking personalities and do so constructively.
I was listening to a Sports show this morning on a coded radio station and to my surprise, one of the analyst was furiously ‘insulting’ the General Secretary of FIFA just because she signed the letter FIFA served Ghana. Unthinkable, honestly I could not “think far but think madness”.
I ask, what exactly is the motivating factor?
We must understand our duty is to educate the general public and not to insult, thinking that will help as execute our agenda.
It is sad how Sports Journalist of my generation takes delight in insulting because of their hate for people who hold certain positions. You can educate to suit your agenda, only if you read wide.
After convincing the public that FIFA should dissolve the GFA, we are now saying the Government had it wrong from day one? Really?
Our game will continue falling if the current Sports Journalists fail to educate but rather continue the insult because of our hate for certain people who hold public offices.
For this reason, Sports Journalists in this country of which I am one of them must ensure that we stick to the truth and facts as we tell them untwisted irrespective of who it addresses just to safeguard the Sporting industry and our chosen career as Sports Journalist.
By Francis Hema, follow on Twitter @FrancisHema5

domain: news


NBC's stunt, using a Vice President of thimerosal lawsuit defendants Johnson & Johnson as their Chief Medical Expert without disclosing her real job is media relations for the Corporation, has garnered the ire of autism parents. Lots and lots of autism parents:
Mr. Steve Capus, President NBC News
30 Rockefeller Plaza
New York, NY 10112
June 13, 2007
Dear Mr. Capus:
The undersigned organizations are writing to you regarding the concerns among families of vaccine-injured children across the country over NBC's recent coverage of the Autism Omnibus proceedings. In particular, we take issue with the comments Dr. Nancy Snyderman made during yesterday's Today show.
While one would hope a "First do no harm" philosophy would have some bearing on the information Dr. Snyderman provides to viewers, clearly it does not.
Dr. Snyderman's ties to Johnson & Johnson, defendants in vaccine injury litigation, are obviously dictating the agenda in her appearances on your network at the risk of the safety of our children. This conflict of interest calls into serious question your journalistic integrity and credibility.
NBC's viewers were exposed to a blatant falsehood yesterday as Dr. Snyderman claimed that vaccines no longer contain mercury. This is not the case,and this misinformation has unfortunately given America’s parents a false sense of security that vaccines are now mercury-free. This false claim puts all of America's children and the unborn at risk of great harm.
The mercury-based preservative thimerosal has never been fully removed from childhood vaccines as Dr. Snyderman vehemently claimed. A simple check on the FDA's website would have confirmed this: http://www.fda.gov/cber/vaccine/thimerosal.htm#t1. Mercury is still in most flu, tetanus, and diphtheria/tetanus vaccines--and an array of vaccines still contain "trace" amounts. (The term "trace" must be used loosely as this aspect of vaccine production is not being regulated and there is some variation on what constitutes a trace amount. As children often receive multiple "trace" amounts of mercury in one sitting, cumulative amounts and potential adverse effects are as yet unknown.)
While no reputable medical practitioner in this country would allow even "trace" amounts of lead to be injected through vaccines given its known neurotoxicity, physicians continue to allow mercury, which exceeds the toxicity of lead by more than 100-fold, to be routinely injected into humans.
As a physician representing NBC, Dr. Snyderman has failed to tell the truth about mercury-containing vaccines and the known dangers associated with them. There is simply no excuse for such careless and false reporting while this country is in the throes of a childhood epidemic of neurological disorders.
During Monday's NBC Nightly News Dr. Snyderman stated, "there really is no science" behind the autism/mercury link. Vaccines and the mercury-based preservative thimerosal have not been ruled out as a cause of autism. To the contrary, there are literally thousands of scientific, peer-reviewed studies supporting the extreme neurotoxicity of mercury and the relationship between mercury exposure and neurological injury. The following link provides a copious amount of research which contradicts what Dr. Snyderman told the American public: http://www.generationrescue.org/studies.html
The CDC's own study conducted in 2000 clearly shows the agency knew that injuries were occurring to children from mercury-containing vaccines, yet the data was manipulated to obscure the link. Lead researcher Dr. Thomas Verstraeten had this to say regarding the CDC’s thimerosal findings:
"...we have found statistically significant relationships between the exposure and outcomes for these different exposures and outcomes. First, for two months of age, an unspecified developmental delay, which has its own specific ICD9 code. Exposure at three months of age, tics. Exposure at six months of age, an attention deficit disorder. Exposures at one, three, and six months of age, language and speech delays which are two separate ICD9 codes. Exposures at one, three, and six months of age, an entire category of neurodevelopmental delays, which includes all of these plus a number of other disorders." (Dr. Thomas Verstraeten, page 40, Simpsonwood meeting transcript)
The full transcript of this secret, closed-door meeting held by the CDC at the United Methodist Retreat Center, Simpsonwood, can be read at NoMercury.org or PutChildrenFirst.org.
Many European countries have banned the use of thimerosal/mercury in vaccines for many years. Seven states have passed legislation banning the use of thimerosal/mercury in vaccines and similar legislation is pending in over 30 additional states. If there was no science to back up the dangers of using mercury in vaccines, we wouldn't be seeing such legislative efforts to ban its use.
In her most recent NBC appearance, Dr. Snyderman was asked why parents were filing claims on behalf of their vaccine-injured children, to which she answered matter-of-factly, "money." This cavalier statement alone goes far beyond contempt and displays an appalling ignorance of the emotional and financial devastation faced by families of vaccine-injured children. This must be addressed by an immediate apology from NBC to all the parents of children suffering from vaccine-induced illnesses.
We urge you to speak with the growing number of scientists who have published research supporting a causal link between mercury in vaccines and neurodevelopmental disorders, and can provide you contact information for these researchers.
Reporting false information is a disservice to the American people. When it comes to the children and the unborn in this country, we should err on the side of safety, regardless of personal belief, conviction, or backing from the pharmaceutical industry.
Based on the misinformation presented by Dr. Snyderman, and the potential for harm this has brought to bear upon children, we ask for her resignation. We will accept nothing less than a full and public retraction of her false statements, along with an apology from your
We expect an immediate response to our request. We can be contacted
at 828-776-0082 or amy@....
Advocates for Children's Health Affected by Mercury Poisoning (ACHAMP)
Autism Healing Network
Autism Recovery Resources of Washington (ARROW)
Autism Solution Center, Inc
Autism Society of Oregon – Lane County Chapter
Coalition for Mercury-Free Drugs (CoMeD)
David A. Geier,Vice-President Institute of Chronic Illnesses, Inc.
Developmental Delay Resources (DDR)
Dr. Boyd Haley, Bio-Chemist, Chemistry Department University of Kentucky
Educate Before You Vaccinate
Foundation For Autism Information and Research
Foundation for Mercury Injured Children
John Wilson, MD Great Smokies Medical Center
K Paul Stoller, MD, President, International Hyperbaric Medical Association
KindTree Productions, Inc
Mark R. Geier, MD, Ph.D., FABMG, President Genetic Centers of America
Maryland Autism Recovery Coalition
Mercury Free Maryland
Moms Against Mercury
Moms of Hope
National Autism Association
SOAR! Salem Oregon Autism Resources
Talk About Curing Autism (TACA)
Texas Autism Recovery
Treating Autism in the UK
US Autism and Asperger Association
World Mercury Project
Thank you so much for writing this blog. I am completely addicted!
I am a Marriage & Family Therapist and also in a PhD program for Medical Family Therapy where my research and clinical focus is working with families who have a family member with ASD.
I am reading and learning as much as I can about the ASD/vaccine link. I am trying to pass it on to soon to be and new parents that I know in my personal life to help prevent further damage to children from vaccines, but it is hard to get my message across with the media presenting a false counter argument.
Have you read "Healing the New Childhood Epidemics: Autism, ADHD, Asthma and Allergies" by Kenneth Bock? I want to get his message across to the numerous clients I see on a daily basis dealing with all the childhood epidemics, but I struggle with not feeling like I know enough yet and if it is out of my scope of practice.
Anyway, thanks again for writing and keeping the world informed about the TRUTH!
Hi, I've never written on or to a blog before. The letter to NBC was wonderful, Ginger. Thank you on behalf of all of us who are in this fight with you and your family.
My grandson has autism. I know what his parents do every single day, in their efforts to help him and teach him. It's non-stop.
I certainly hope NBC fires this Dr. Snyderman, and I hope people understand WHY. She said her thing last week, and on Saturday in the Washington Post's editorial about the week's events re the Vaccine Hearings, the writer made the same identical false comment about there no longer being mercury in vaccines. Patently untrue!
I have now written to the Washington Post and I hope many other parents do too.Their editorial was dismissive about the pain families suffer when their child has autism. The Post pretty much said, "Oh, well....we just don't know enough about it yet."
I say "We know the truth, or at least a good part of it." Now we must help get the word out despite the efforts of those who hide in the deep pockets of big pharmaceuticals. Our children's health is soooo much more important than the pro-vaccine lobbyists' extra income.
Keep fighting the good fight, Ginger.
I am shocked that so many people are oblivious and even sometimes downright hostile to autism and our search for its causes and a cure.
I posted a comment about Dr. Snyderman and the whole thimerosal/autism link at a DailyKos, and I'm disappointed that so many people there chose to label me as a "conspiracy theorist."
The media is really behind Big Pharm on this one and so much of the public is buying their side of the story.
From the very beginning, any digital product development project needs a clear idea of what exactly to build and why. Often, the “clear idea” can be associated with a long list of requirements - a fixed list of project specifications. Quite a scary phrase, agree? https://cxdojo.com/what-you-should-know-about-user-stories
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Decorating a Glass Coffee Table
A glass coffee table can make a room look cleaner and more modern, but the lack of texture and color can also make it feel austere. Styling it can help it fit into the room’s environment. Here are some tips to consider when decorating a glass coffee table.
Choose the Right Size
One way to make sure that the coffee table looks balanced in the space is to choose one of the right size. A table that is too small will look undersized, while a table that’s too large could monopolize the room and make it difficult to navigate.
Pick the Right Color for the Base
Glass coffee tables are usually made with metal or wooden bases of a neutral color, such as black, gunmetal, or even brass. When picking the base color, consider the room’s other features. If the room contains several other black items, go with a different metal finish, such as brass. That said, black is still a safe bet as it will blend in with everything.
Bring in Some Texture
Since glass is a relatively flat surface, it can make the room feel clinical. To avoid this, bring in some form of texture, like:
- Rugs – A cozy rug can be the perfect way to tie the table into the rest of the space. Choose one that matches the other colors in the room.
- Cushions – Placing a few cushions around the table can add extra comfort.
- Books – Stack some design books around the base for color, texture, and personality.
- Plants – Place some plants or flowers on top or around the table to bring in color, texture, and life.
Use a Table Cloth
A table cloth is a great way to incorporate more texture and color into the room. Choose one that complements the other colors in the room, and be sure to get one that is designed for a glass surface. If a tablecloth isn’t for you, consider using a placemat, or hang a tapestry over the top of the table.
These tips will help you make sure that the glass coffee table fits in with the rest of the room. With these decorating tools, you can create a stylish and inviting area.

domain: design


We are official and exclusive distributors of the best international machine tool brands. We offer the most innovative technology to the most outstanding companies in the sector.
We have a highly specialized staff of more than 75 professionals who know the latest technologies, which make our clients grow in terms of innovation, quality and productivity.
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FOUNDED IN 1971
Don Esteban Arambarri is the founder of this company with more than 50 years of experience in the field of engineering. Our extensive experience has positioned us as the leading company in the distribution of machine tools in Spain and Portugal.
Currently, Delteco is in charge of a younger and more dynamic second generation, offering a modern vision, in accordance with the current characteristics of the market.
Delteco's strength lies in its clear identity, the unique ability to create technological solutions that contribute to the success of our customers.
We are close to you thanks to our wide sales network. We have the human, technical and organizational resources necessary to offer the best solutions to our customers throughout the entire Iberian Peninsula.
In addition to our headquarters located in Zumaia, we have delegations in Madrid, Levante, Catalonia, Asturias, Galicia, Aragon, Castilla y León, Andalusia and Portugal.
We provide the highest level of quality and excellence, because it is what customers demand of us. Since our foundation we have maintained a clear commitment to the continuous improvement of products, processes and technologies, thanks to our strict Delteco Quality Policy.


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The B-RV1-X is a mid-sized tower with soft curves and elegant angles. The front and back of the chassis are almost completely open, creating an airy feel. A 5mm full-screen tempered seamless glass side panel allows for an unobstructed view of the internal hardware, showcasing the build details. The chassis features 98mm of CPU cooler clearance and 390mm of graphics card clearance.
- Water Cooling Compatible Solution.
- Oversized GPU Compatible (390mm max)
- 360mm (3x120mm) Radiator Support
- 5mm Tempered Glass Side Panel
- Open Air Concept
- Case Material: Tempered Glass / High Quality Acrylic / Anodized Aluminum
- Dimensions: 526mm x 457mm x 270mm
- Power Cord Length: 190mm
- CPU Cooler Max height: 98mm
- Graphics Card Limit: 390mm
- Motherboard: Mini ITX / Micro ATX / ATX
- Fans: 6
- Radiator Support: 2 x 360mm
- 3.5" Drive Tray: 2
- 1x Tower Chassis
Some secondary pictures show hardware / cooling components to show visual possibilities and are NOT included.Not responsible for any damage caused by or when using this product. Please use at your own risk.

domain: hobby


The Guide To
The Biography of
Guitar Music Theory Articles
What Metallica has in common with the X-Files theme? They both use the same kind of chords and arpeggios to get a spooky and mysterious sound. Learn here what those are and how you can use them too!
Check out these awesome, lush sounding chords you can create with an open G tuning on your guitar. Open tunings provide all sorts of opportunities for your guitar playing that you just cannot get with standard tuning. Learn how to not only get these great sounding chords but how to create great sounding music with them too.
In this article I am going to explain to you a super fun technique to add into your next guitar solo. It's called Arpeggio Superimposition. And don't worry, it's not nearly as complicated as it sounds.
Lots of people who have never taken the time to properly learn theory will try to argue that you don't actually need it to compose music. I know this because I receive these kind of comments on my posts every couple weeks. So I thought we should take some time to break down if there is any merit to this statement.
After you've been playing music for a little while, it's easy to feel like you don't need theory to help you at all. Or that perhaps you are too old to start taking on something new. Is there any truth in this? Or are you only holding yourself back by putting it off?
How to find out quickly, which notes a chord contains? How this knowledge could help you to make chords sound more interesting? And, after all, why learning this skill is so necessary for a good musician? This column is for those, who are already familiar with the notes, chords, triads and how they are made.
Articles saying music theory is difficult and not worth learning are penned every day, but is there really any truth to them? Or are they keeping you from reaching your potential?
Get out of the open chord/bar chord rut many players find themselves in. Learn these advanced sounding, yet easy to play guitar chords that can be used all over the neck of the guitar. These chords can be used in any style and are very useful in both a soloing and rhythm context.
When you pick up your guitar, do you find that your fingers instinctively move to the same progressions you've heard over and over? Do you ever wonder how professional musicians always seem to freshen up their sound? If you've found yourself in this place before, then this simple technique might help you out.
Do you break your guitar scales into multiple positions on the fretboard? How many? Do you feel that you need to learn more of these, or do you already know too many?


The 2018 Infiniti Q50 is a sleek and stylish luxury sedan that’s sure to turn heads when you’re out on the town. The Q50’s tail lights are particularly striking, with their LED accents and distinctively shaped housing. Whether you’re looking for a sophisticated ride for your daily commute or a head-turning car for special occasions, the Q50 is definitely worth considering.
The 2018 Infiniti Q50 is a workhorse of a sedan. It’s comfortable, efficient, and stylish all at the same time. One of the best features of the Q50 is its tail lights.
They’re sleek and modern, and they really make the car stand out on the road. If you’re looking for a new car that will turn heads, the 2018 Infiniti Q50 is definitely worth considering. And if you love amazing tail lights, this car is definitely for you!
2018 Infiniti Q50 Aftermarket Tail Lights
If you’re looking to upgrade your 2018 Infiniti Q50’s tail lights, there are a few things you need to know. First, there are a few different types of aftermarket tail lights available: LED, halogen, and HID. LED tail lights are the most popular option because they’re the brightest and most energy-efficient.
Halogen tail lights are a good middle-of-the-road option, while HID tail lights are the brightest but require more power to operate. Once you’ve decided on the type of tail light you want, it’s time to pick a style. There are plenty of different designs to choose from, so take your time and find something that really speaks to you.
If you want something that’s really going to stand out, go for an LED design with chrome or smoked housing – these look great and will definitely turn heads when you’re driving down the road. Finally, make sure you get your new tail lights installed by a professional. While it’s possible to do it yourself, it’s not recommended unless you have experience with car electrical work.
Installation is typically pretty straightforward – just follow the instructions that come with your newtail light kit – but if anything goes wrong, it’s better to be safe than sorry and have someone who knows what they’re doing handle it.
How Do I Change the Tail Light Bulb on My 2018 Infiniti Q50
Assuming you would like instructions on how to change the tail light bulb on a 2018 Infiniti Q50, here are the steps:
1. Open the trunk and locate the two screws that secure the taillight assembly in place. Remove these screws with a Phillips screwdriver.
2. Carefully pull the taillight assembly away from the car body. Be careful not to touch or damage any of the other wires or components in this area as you do this. 3. Locate the burned out bulb and twist it counterclockwise to remove it from its socket.
4. Insert a new bulb into the socket and twist it clockwise until tight. 5. Reattach the taillight assembly to the car body using the two screws you removed earlier, making sure not to overtighten them as this could strip their threads or break them entirely.
What are the Different Types of Bulbs Available for the 2018 Infiniti Q50 Tail Lights
2018 Infiniti Q50 Tail Lights
There are many different types of bulbs available for the 2018 Infiniti Q50 tail lights. The most popular type is the LED bulb.
LED bulbs are known for their bright light and long life span. They are also very energy efficient. Other popular types of bulbs include halogen, xenon, and incandescent.
LED Bulbs LED bulbs are the most popular type of bulb for the 2018 Infiniti Q50 tail lights. They are known for their bright light and long life span.
They are also very energy efficient. Halogen Bulbs Halogen bulbs are another popular type of bulb for the 2018 Infiniti Q50 tail lights.
Halogen bulbs produce a bright white light that is similar to daylight. They also have a long life span and are very energy efficient. Xenon Bulbs
Xenon bulbs are a type of high intensity discharge (HID) bulb. Xenon bulbs produce a very bright white light that is similar to daylight. They have a shorter life span than LED or halogen bulbs, but they use less power than other HIDbulbs such as metal halide or mercury vapor bulbs.
Incansecent BulbsIncandescentBulbs Incandescentbulb sare not as popular as they used to be because they are not as energy efficient as LED or halogenbulbs . However,they still provide good lighting andhave a relatively long lifespan .
Can I Install Led Bulbs in My 2018 Infiniti Q50’S Tail Lights
As of 2018, there are no LED bulbs that are approved by Infiniti for the Q50’s tail lights. While some aftermarket companies may offer LED bulbs that claim to be compatible with the Q50, it is not recommended to install them as they have not been tested or approved by Infiniti and could potentially cause problems with the car’s electrical system.
How Do I Aim the 2018 Infiniti Q50’S Tail Lights
If you need to replace a burnt out brake light or tail light on your 2018 Infiniti Q50, the process is pretty easy. The first thing you’ll need to do is open up the trunk and locate the two screws that hold the taillight assembly in place. Once you remove those screws, you’ll be able to pull the entire assembly out and access the bulbs.
To remove a bulb, simply twist it counterclockwise and pull it out. You can then insert a new bulb into the socket and twist it clockwise until it’s tight. Repeat this process for each of the bulbs in the tail light assembly.
Once all of the bulbs have been replaced, just put the assembly back in place and screw it in tightly.
My2018 Infiniti Q50’S Taillights are Not Working, What Could Be the Problem
If your 2018 Infiniti Q50’s taillights are not working, it could be due to a few different things. First, check to see if there is any debris or build-up on the taillight lenses. If so, clean them off with a soft cloth and some water.
Next, check the bulbs themselves to see if they are burned out. If they are, replace them with new ones. Finally, check the taillight fuse to see if it has blown.
If so, replace it with a new one of the same amperage.
How to replace tail light 2014-2019 INFINITI Q50 Q50S
The 2018 Infiniti Q50 comes with LED taillights as standard equipment. These lights are not only bright, but they also use less energy than traditional taillights. The LED taillights on the 2018 Infiniti Q50 are a great safety feature that will help you see and be seen when driving at night.


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Kit Connor of the Netflix series Heartstopper has signed on to star in the mystery horror film One of Us, filming soon in Ireland
Kit Connor, who earned a lot of fans and won the Outstanding Lead Performance award at the inaugural Children’s and Family Emmys for his performances as Nick Nelson in season 1 of the Netflix series Heartstopper, has now signed on to lead the cast of the mystery horror film One of Us, Deadline reports. The feature debut of writer/director Stefan van de Graaff, One of Us is scheduled to begin filming in Belfast, Northern Ireland later this month.
Described as an “allegorical film”, One of Us will show viewers what happens when members of a family begin dying one by one at a funeral, while Youngest (Connor) searches for the stranger in their midst.
Connor is being joined in the cast by Callum Woodhouse (The Durrells), Charlotte Hope (The Spanish Princess), Siobhan Fallon-Hogan (Rushed), and Ian Beattie (Game of Thrones) .
Coming our way from the Jung School and Northern Ireland Screen, One of Us is being produced by Raquel Baldwin, with Robert Machoian co-producing and van de Graff serving as executive producer. Bianca Cline, the Marcel the Shell With Shoes On cinematographer who was recently hired to fill in for the late Halyna Hutchins on the troubled (that’s an understatement) Western production Rust when it resumes filming, is the cinematographer on this project as well.
In addition to Heartstopper, Connor’s credits include Rocketman and His Dark Materials. And yes, he will be reprising the role of Nick Nelson in Heartstopper season 2.
How does One of Us sound to you, and what do you think of Kit Connor leading the cast? Leave a comment below to let us know what you think of Kit Connor leading the cast. I really liked Connor’s performance in Heartstopper, so I’m glad to hear he’s going to be starring in a film that’s part of my favorite genre, horror.
It will be interesting to learn more about the story of One of Us, because I can’t hear that phrase without immediately thinking of the 1932 film Freaks (and the Freaks-inspired song by The Ramones, “Pinhead”). I doubt this movie has anything to do with Freaks or The Ramones, but we’ll share updates on One of Us as we hear more about it.


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Progressive. Collaborative. Accountable. Draw on your passion. Shape our community. Progressive and collaborative, with a clear, long-term vision. We value employees’ contributions and inspire excellence. We are driven by a desire to help shape and serve the growing community in which we live and work.
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Successful completion of a Post Secondary Diploma/Certificate (1 year or more) in Business Administration or Professional Program or related field or approved equivalent combination of education and experience.
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How to Apply
Please apply online by December 7, 2020. We thank all candidates for their interest; however, only those selected for an interview will be contacted via email.
$34.48 to $37.48 per hour

domain: law


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Vishwa Hindu Parishad leader Pravin Togadia today asked the Centre to tread the path of Sardar Vallabhbhai Patel and enact a law to pave way to build Ram temple in Ayodhya. DNA, 1 month ago
3 images for "pravin patel"
Posted by Equitymaster India's IT services sector has been in the limelight ever since Donald Trump took over the US presidency, thanks to his anti-immigration rhetoric and protectionist policies. Recently, the Trump administration accused Indian IT majors, ...Equitymaster.com, 9 hours ago
IMAGE: Royal Challengers Bangalore captain will expect his batsmen to come good against Sunrisers Hyderabad after his bowlers put on a good display against Kolkata Knight Riders on Sunday. Photograph: BCCI Stung by a batting debacle, Royal Challengers Bangalore have the onerous task of picking up pieces when they face defending champion Sunrisers Hyderabad on Tuesday, with a singular aim of keeping their hopes alive in the Indian Premier League. It will be an arduous task for Virat Kohli and ...Rediff.com, 2 days ago
IMAGE: Bhuvneshwar Kumar has been outstanding, especially in death overs. Photograph: BCCI Back-to-back losses denting their confidence, defending champions Sunrisers Hyderabad would look to put their campaign back on track when they take on Kings XI Punjab in their IPL match, in Hyderabad, on Monday. The Sunrisers had a perfect start this season by winning their first two games -- against Royal Challengers Bangalore and Gujarat Lions -- at home. However, they lost their next two matches away ...Rediff.com, 1 week ago
IMAGE: Gautam Gambhir. Photograph: BCCI Buoyant Kolkata Knight Riders will look to continue their winning momentum when they face defending champions Sunrisers Hyderabad in the Indian Premier League, in Kolkata, on Saturday. It will be a battle between two top bowling sides of the IPL and Kolkata will hope to avenge their defeat in the Eliminator round last season. After a win and a loss, the two-time former champions began their campaign at home with an eight-wicket thrashing of Kings ...Rediff.com, 1 week ago
Mumbai Indians face a tough battle against an in-form Sunrisers Hyderabad, who are high in confidence after starting off IPL 10 with a couple of comprehensive victories. IMAGE: Mumbai Indians players in a huddle. Photograph: BCCI Confidence bolstered after an inspirational run chase against Kolkata Knight Riders, a confident Mumbai Indians is ready to lock horns with defending champions Sunrisers Hyderabad in an Indian Premier League encounter, in Mumbai, on Wednesday.It will be a battle of ...Rediff.com, 2 weeks ago Indian Premier League 10: Can Sunrisers Hyderabad retain their title? catchnews.com, 2 weeks ago
One thing is clear: the BJP will be fighting the Gujarat Assembly elections on a Hindutva plank. Take three developments for instance – the passage of a legislation raising the sentence for cow slaughter, the recent communal violence in Patan and the ...catchnews.com, 2 weeks ago
IMAGE: Sunrisers Hyderabad celebrate. Photograph: BCCI Gujarat Lions will be keen to shrug off the disappointment of a humiliating defeat against Kolkata Knight Riders as they gear up to face defending champion Sunrisers Hyderabad in their first away game of the Indian Premier League, in Hyderabad, on Sunday. Sunrisers are high on confidence after a comfortable 35-run win in their opening game against a depleted Royal Challengers Bangalore while Gujarat Lions were demolished by the KKR ...Rediff.com, 2 weeks ago
A total of 66 players were sold including 27 overseas players in the 2017 Indian Premier League (IPL) Auction at the Ritz-Carlton hotel in Bengaluru on Monday. The top pick being England all-rounder Ben Stokes who was sold to Rising Pune Supergiants for a ...Sify, 2 months ago #IPL10 Auction: From Ben Stokes to Rashid Khan, complete list of all the players sold DNA, 2 months ago Live: IPL Auctions 2017 Sify, 2 months ago Live Updates of IPL 2017 auction DNA, 2 months ago
Basil Thampi / Photo: C Biju Bengaluru: England all-rounder Ben Stokes was the costliest buy after the first round of IPL players auction on Monday, going to Rising Pune Supergiants for a whopping Rs 14.50 crore (USD 2.16 million) after an intense bidding ...Mathrubhumi, 2 months ago
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Last weekend, we kicked off our Academy Fall Session with an Open House Event at our studio! We had delicious snacks, offered example classes, held a raffle for BFan apparel, and there was even a surprise performance by our company dancers. Not only did we get to see our wonderful academy dancers after taking a short break for the summer, but we also were able to meet many new academy dancers that are joining us this week!
Above: A special ballet class with Executive Director, Ms. Hannah!
Above: Ms. Cari & Mr. Natanael during their surprise performance for our Open House guests!
Enrollment is still open at the Ballet Fantastique Academy. To enroll your dancer, visit our academy website.
Adult classes are also offered at the Ballet Fantastique Academy. For more information, visit our academy website.


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Free Hayride 2 in Best LookNow you can download full Hayride 2 in best quality with duration 92 Min and was published in 2015-03-06 and MPAA rating is 2.
- Original Title : Hayride 2
- Movie title in your country : Hayride 2
- Year of movie : 2015
- Genres of movie : Thriller, Horror, Action,
- Status of movie : Released
- Release date of movie : 2015-03-06
- Companies of movie :
- Countries of movie :
- Language of movie : English,
- Durationof movie : 92 Min
- Average vote of movie : 4.3
- Youtube ID of movie : pVmjEbi9_FY
- Translation of movie : EN,RU,ES,
- Cast of movie :Sherri Eakin (Amanda), Jeremy Sande (Corey), Jeremy Ivy (Steven), Corlandos Scott (Detective Loomis)
Movie synopsis of Hayride 2 :
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domain: entertainment


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Are you tired of your school or workplace blocking your favorite online games? Look no further than Unblocked Games 67! This website offers a vast selection of free online games, from classic arcade favorites to modern multiplayer adventures. But before you dive headfirst into the world of unblocked gaming, it’s important to understand what it is and how it works. In this ultimate guide, we’ll explore the ins and outs of Unblocked Games , discuss the pros and cons of free online gaming, highlight some popular game options available on the site, and provide tips for getting started. So sit back, relax (but not too much), and let’s get ready to game!
What is Unblocked Games 67?
Unblocked Games 67 is a website that provides access to free online games. The site is specifically designed for people who are looking to play games at school or work, where traditional gaming websites may be blocked by firewalls and security protocols. Unblocked Games offers a simple way to bypass these restrictions and enjoy your favorite games without any hassle.
The site features a wide variety of game genres, including action, adventure, puzzle, sports, racing, and more. Whether you’re looking for something fast-paced and exciting or slow-paced and relaxing, there’s sure to be a game that suits your style.
One of the benefits of Unblocked Games is that it doesn’t require any downloads or installations. All you need is an internet connection and a compatible device (such as a laptop or tablet) in order to start playing.
Another key feature of the site is its user-friendly design. The homepage offers quick links to popular games as well as search functionality so you can easily find specific titles. Additionally, the site includes helpful information such as game ratings and descriptions so you can make informed choices about what to play.
Unblocked Games provides an excellent platform for gamers who want easy access to free online entertainment no matter where they are.
The Different Types of Free Online Games
Free online gaming has grown significantly in recent years, and there are many different types of games available for players to enjoy. One popular type is action games that require quick reflexes and sharp shooting skills. These games often feature fast-paced gameplay, explosive graphics, and challenging levels that keep you coming back for more.
Another common type of free online game is puzzle games. These are perfect for those who like a mental challenge as they require logic and problem-solving skills to complete tasks. Puzzle games can range from simple matching or jigsaw puzzles to complex escape room scenarios.
Strategy games also make up a significant portion of free online gaming options. Players must use their critical thinking abilities to plan out their moves while anticipating the opponent’s next move. Strategy-based titles include real-time strategy (RTS), tower defense, turn-based tactics (TBT), and role-playing strategy (RPS).
Simulation games allow players to immerse themselves into virtual worlds where they can experience anything from running a business empire to being an animal caretaker at a zoo sanctuary.
Sports fans will find plenty of free online sports-themed video game options ranging from football/soccer/fantasy leagues simulations like Football Manager 2021 or NBA 2K21 Online Playable Demo editions with both single-player campaigns against AI bots or multiplayer matches versus other human users around the world!
Pros and Cons of Playing Free Online Games
Free online games have become increasingly popular among people of all ages. While they offer a wide range of benefits, there are also some drawbacks associated with playing them.
One of the biggest advantages is that free online games provide an entertaining and engaging way to pass the time. They can be played from any device, anywhere in the world, making them easily accessible for everyone.
Another advantage is that free online games can help improve cognitive skills such as memory, problem-solving and decision-making. Games like puzzles and strategy-based ones challenge your brain in different ways which helps you develop these skills.
However, playing too many free online games can lead to addiction which may affect other areas of your life including work or studies. Additionally, some games may contain violent or inappropriate content which could negatively impact younger audiences.
There’s also a risk factor when it comes to downloading certain free online games as malware-infected versions could harm your computer or mobile device without users realizing it.
It’s important to balance our enjoyment with responsibility when it comes to gaming activities as we don’t want our passion for gaming becoming counterproductive towards our well-being.
What Games are Available on Unblocked Games 67?
Unblocked Games offers a wide variety of games that cater to different preferences and age groups. From action-packed shooting games to puzzle-solving adventures, there is something for everyone on this platform.
For those who love strategy and simulation games, Unblocked Games offers titles such as Kingdom Rush Frontiers and Papa’s Sushiria. These games allow players to test their management skills in running restaurants or defending kingdoms from invading enemies.
For those who prefer fast-paced action, there are popular titles like Super Smash Flash 2 and Strike Force Heroes. These games offer adrenaline-fueled battles with various characters and weapons.
Fans of classic arcade-style gaming can enjoy the likes of Pac-Man or Tetris on Unblocked Games . These timeless favorites never go out of style and still provide hours of entertainment for gamers young and old alike.
Unblocked Games also has a selection of educational games that make learning fun for kids. Titles like Typing Ninja Hunter help improve typing speed while having fun at the same time.
Unblocked Games 67 has an extensive library that caters to all interests from casual gamers to avid enthusiasts looking for more challenging gameplay experiences.
How to Play Free Online Games?
Playing free online games is an enjoyable way to pass the time, but it can be daunting if you’re not tech-savvy. Here are some simple steps to follow so anyone can play these games with ease.
Firstly, make sure your internet connection is stable since lag or disconnection can ruin your gaming experience. Once you have a secure connection, go to Unblocked Games and select a game that interests you.
Next, read the instructions on how to play the game before starting. Most of them will have tutorials or guides that explain the rules and controls, which could save you from making mistakes during gameplay.
After reading through the instructions, start playing! Use your keyboard and mouse (or touch screen) to control characters and navigate through different levels of the game. Remember that practice makes perfect – don’t get discouraged if you don’t succeed at first.
Keep in mind that some games may require additional software/plugins like Adobe Flash Player or Java Runtime Environment for smooth performance; make sure they are installed on your computer beforehand.
By following these straightforward guidelines for playing free online games effectively on Unblocked Games site – anyone can become an expert gamer in no time!
Alternatives to Unblocked Games
Although Unblocked Games offers a vast collection of free online games, there are other alternatives available for those looking for something different or more up-to-date. One such alternative is Cool Math Games. This website provides a range of math-based games that are fun and engaging while also helping to improve mathematical skills.
Another popular option is Kongregate, which offers a wide variety of games in various categories such as action, adventure, strategy, puzzles and more. It features both single-player and multiplayer options with social elements like chat rooms for communication with other gamers.
For those who enjoy some nostalgia or classic arcade-style gaming experience, consider visiting RetroGames.cz. This website allows you to play retro video games from consoles like Nintendo Entertainment System (NES), Sega Genesis and Game Boy Advance among others.
Armor Games is another great alternative that has been around since 2004 offering new and exciting titles weekly along with classics from the past. The platform boasts over 3k+ game library in genres ranging from RPGs to puzzle adventures.
Unblocked Games may be an excellent source of free online entertainment but don’t limit your options just yet! There are many alternatives available on the internet that cater to individual preferences when it comes to gaming experiences.
To sum it up, Unblocked Games is the ultimate guide to free online gaming. With a vast collection of exciting games available on its platform, you can enjoy playing games without any restrictions or interruptions. However, like everything else in life, there are pros and cons to playing these games.
While they can be a great source of entertainment and help you relax after a long day at work or school, excessive gaming can also lead to addiction and have adverse effects on your health. Therefore, it is essential to maintain a balance between your virtual world and real-life responsibilities.
Whether you’re looking for action-packed shooters or relaxing puzzle games that help sharpen your brain skills – Unblocked Games has got it all covered! So go ahead and explore the world of free online gaming today – who knows what kind of adventure awaits you!


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Ayurveda, an ancient system of medicine originating in Indian subcontinent, encompasses a holistic approach to health and well-being. Dating back thousands of years, Ayurveda focuses on achieving harmony and balance within the body, mind, and spirit. Derived from Sanskrit, “ayur” means life, and “veda” means knowledge or science, emphasizing its comprehensive understanding of life and healing. Ayurveda views each individual as unique, with their own specific constitution and balance of elemental forces known as doshas (Vata, Pitta, and Kapha). By promoting preventive care, proper nutrition, herbal remedies, lifestyle modifications, and therapeutic practices, Ayurveda aims to restore and maintain optimal health by addressing the root causes of imbalances rather than merely treating symptoms. With its holistic and personalized approach, Ayurveda continues to inspire and guide individuals on their journey towards vitality, longevity, and a harmonious existence.
I was looking into getting back into guitar, and need a good beginner guitar for about 30-35k. Please recommend me your top picks, amp suggestions are also welcome.
View on r/IndianStockMarket by wrecxy
Beginner and 35K, do they go together?
Ibanez GIO GRGGR131EX. Always go with ibanez don’t fall into trap of buying squier or epiphone
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domain: health


What’s inside a basic toolbox that everyone should have?
My ex-husband used to do all of the home improvement projects around the house. When we divorced, he was kind enough to leave me a basic tool box with some tools. I look back and laugh because at the time, I couldn’t tell you the difference between a flat head screwdriver or a Philips head and how a wrench was different than pliers. The whole thing scared me to death! Its time to conquer your fears if you feel the same way.


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This exhibit is showing in the Feature Gallery at the Alberta Craft Council through March 25th: a response to the Alberta governments cut of $5 million in 2009.
Since 2005, the ACC has organized:
- 79 exhibitions in Edmonton and Calgary;
- 5 touriing exhibitions seen in more than 100 rural communities;
- 9 exhibitions elsewhere in Canada;
- 4 exhibitions in the United States and South Korea.
I am a new member of the ACC, and a budding artist. Currently I'm working on a piece for submission to an upcoming juried ACC show. I am funding my work from a small pension and the cash I gleaned from the sale of my Calgary home, along with a supply of materials I amassed while working for over 30 years in the financial sector in Calgary. My membership in the ACC will bring my work to light, for the enjoyment of all who value textiles as an art medium.
My son is a talented actor.
My daughter is a talented photographer.
We all support the arts. Do you?
To urge our Provincial Government to restore funding to the Alberta Foundation for the Arts (which, in turn, funds our Craft Council and other artistic activities in the Province), contact:
- Premier Ed Stelmach
- Lindsay Blackett, Minister of Culture and Community Spirit
- and/or your Local MLA


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2020/04/03· Have any questions? Please get in touch with any questions or queries you may have and our friendly team will do their best to help you. Sales 02392 637 100 Sales 02392 637 900 [email protected] Visit our Contact page for more information.
2020/08/07· Ajax Machine Tools are leading European machine tools specialists and we have a comprehensive range of Milling Machines for you to choose from. We have many decades of industry experience and supply some of the highest quality milling machines currently available.
The Schaublin 13 is probably one of the most desirable small tool-room milling machines. More than 4400 machines were built between 1947 and 1988 and during this time a number of significant changes took place. All machines featured variable spindle speeds from the familiar Reeves-type belt-driven variator via a two speed gearbox and power feeds
Welcome to the Cowells Small Machine Tools website. Established in 1975, we have for the past 38 years been manufacturing small lathes, micro lathes, compact lathes, watch makers lathes, clock makers lathes, bench top lathes and milling machines to a very wide range of end users across the world.
2020/10/17· This machine is a perfect hobby milling machine and also a fantastic base for a CNC conversion. Availability: In stock SKU: EMV-25VBB Categories: Emvio Engineering products,Manual machines,Manual milling machines Tags: belt drive,benchtop mill,brushless motor,hobby mill,machine tools,milling,milling machine,QTC,R8 spindle,Variable speed


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STARKVILLE – On a cold night at Dudy Noble Field, No. 7 Mississippi State could not get the bats heated up as the Bulldogs dropped a 2-1 decision to San Diego Friday in the opening game of a three-game series.
The Bulldogs almost snatched victory at the end when Gavin Collins had a potential game-winning two-run home run sail just left of the foul pole in the ninth inning. In the end, pinch runner Jake Vickerson was stranded at third base.
After winning 13-straight games to start the season, MSU (13-2) has been held to six hits each in consecutive losses to Arkansas-Pine Bluff and San Diego.
San Diego (5-6) scored in the second inning without the benefit of a base hit, thanks to a walk, hit batter, stolen base and wild pitch. The Toreros extended the lead in the fourth inning when another run trotted home on a wild pitch.
The tough Bulldog luck spoiled Preston Brown’s sixth career quality start. In his third-straight quality start, Brown (3-1) allowed five hits and two runs (one earned), with five strikeouts. Brown did walk three and hit another. Ross Mitchell threw 2.2 innings of one-hit shutout relief.
MSU finally broke through in the eighth inning. Cody Brown drew a leadoff walk, advanced to second base on a wild pitch and later scored on an RBI-single by Seth Heck.
In the ninth inning, Wes Rea started things with a leadoff single. A sacrifice bunt moved pinch runner Vickerson to second base before he was later stranded at third base.
Heck had his third straight two-hit game for the Bulldogs, while Brown also had multiple hits.
Ryan Kirby had two hits for San Diego.
David Hill (2-2) threw seven innings, allowing four hits and no runs to earn the win. Anthony McIver worked the Toreros out of a tight spot in the eighth inning and finished the game for his second save.
The series resumes at 2 p.m. Saturday.
(From MSU Media Relations)


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Are Older Millennials Moving Out Of The Inner Cities Real Estate Investing Today
In civilian labor force, total, percent of population age 16 years , 2014 2018 62.9% in civilian labor force, female, percent of population age 16 years , 2014 2018. Of these individuals, 253,768,092 were adults that were 18 years old or older. this is equal to 77.6 percent of the country’s population. utah reported the lowest adult population, with 70.5 percent of its residents being of legal adult age. [pdf] or denotes a file in adobe’s portable document format.to view the file, you will need the adobe® reader® available free from adobe. [excel] or the letters [xls] indicate a document is in the microsoft® excel® spreadsheet format (xls). Definitions: population by child and adult categories. data presented for 2010 through 2019 are vintage 2019 population estimates. each year the u.s. census bureau revises their post 2010 estimates. therefore, data presented here may differ from previously published estimates. The estimated population of the u.s. was approximately 328.2 million in 2019, and the largest age group was adults aged 25 to 29. there were twelve million males in this age category and around 11.
Census Fewer Adults Living With Spouse More Living With Parents Mrctv
United states urban population currently, 82.5 % of the population of the u.s.a. is urban (271,365,914 people in 2019) population density. the 2019 population density in the united states is 36 people per km 2 (93 people per mi 2), calculated on a total land area of 9,147,420 km2 (3,531,837 sq. miles). Update to date information about population of united states in 2020. population of united states: today, historical, and projected population, growth rate, immigration, median age. data tables, maps, charts, and live population clock. The united states had a population of 310 million people in october 2010, and is projected to reach 400 million by 2039 and 439 million in 2050.     it is further projected that 82% of the increase in population from 2005 to 2050 will be due to immigrants and their children. The older foreign born population in the united states: 2012 2016 these foreign born tables are from the 2012 2016 american community survey. table. aging population in the u.s. acs 2011 2015 measuring america's people, places, and economy. The largest population: california 39,937,489. according to the public policy institute of california, one of every eight united states residents lives here in the golden state (according to their 2019 data). world population review’s statistics show that cali is way ahead of texas, with close to 10 million more people. texas is also much larger.
2 Older Adults Who Need Caregiving And The Family Caregivers Who Help Them Families Caring For
Unlike china and india, the united states population is expected to continue to grow throughout the century with no foreseeable decline. by 2067, the u.s. population is expected to surpass 400 million people. the population growth in the united states is mainly attributed to high rates of immigration, which have decreased since 2016, and the natural increase (the difference between births and. This is a list of united states of america states by population as of 2019.the list was made using the 2019 census estimates taken by the united states census bureau.the total population of the united states was 330,150,668 at the december 2019 census these numbers include all people other than people just visiting: these include citizens, non citizen permanent residents and non citizen long. Literacy rate, adult total (% of people ages 15 and above) literacy rate, youth male (% of males ages 15 24) malaria cases reported; mortality rate, under 5 (per 1,000) people practicing open defecation, urban (% of urban population) physicians (per 1,000 people) population ages 65 and above (% of total) population growth (annual %). The henry j. kaiser family foundation headquarters: 185 berry st., suite 2000, san francisco, ca 94107 | phone 650 854 9400 washington offices and barbara jordan conference center: 1330 g street. Definitions: adult population by race. data presented for 2010 through 2019 are vintage 2019 population estimates. each year the u.s. census bureau revises their post 2010 estimates. therefore, data presented here may differ from previously published estimates.
Most U S Adults Plan To Fill Out 2020 Census But Some Aren T Sure Pew Research Center
Graph and download economic data for working age population: aged 15 64: all persons for the united states (lfwa64ttusm647s) from jan 1977 to sep 2020 about working age, 15 to 64 years, population, and usa. Moreover, people 50 plus will continue to grow over the next decade to the tune of 19 million, vs. a growth of only 6 million for the 18 49 population. not surprisingly, 53.5 percent of americans age 50 plus are women, as they live longer than men. This demographic transformation caused by a rapidly aging population is new for the united states but not for other countries. japan has the world’s oldest population, where more than one in four people are at least 65 years old. already, its population has started to decline and, by 2050, it is projected to shrink by 20 million people. June 25, 2020 — the u.s. census bureau today released estimates showing the nation’s 65 and older population has grown rapidly since 2010, driven by the aging of baby boomers born between 1946 and 1964. the 65 and older population grew by over a third (34.2% or 13,787,044) during the past decade, and by 3.2% (1,688,924) from 2018 to 2019. The demographics of sexual orientation and gender identity in the united states have been studied in the social sciences in recent decades. a 2017 gallup poll concluded that 4.5% of adult americans identified as lgbt with 5.1% of women identifying as lgbt, compared with 3.9% of men. a different survey in 2016, from the williams institute, estimated that 0.6% of u.s. adults identify as transgender.
Usa Adult Population Nude Moives
The following table lists the 317 incorporated places in the united states (excluding the u.s. territories) with a population of at least 100,000 on july 1, 2019, as estimated by the united states census bureau.five states—delaware, maine, vermont, west virginia and wyoming—have no cities with populations of 100,000 or more. the table below contains the following information:. Countries in the world by population (2020) this list includes both countries and dependent territories.data based on the latest united nations population division estimates. click on the name of the country or dependency for current estimates (live population clock), historical data, and projected figures. In this study, we surveyed the adult us population to understand their risk perceptions about the covid 19 outbreak. we used an online platform to survey 718 adults in the us in early february 2020 using a questionnaire that we developed. Women, young adults have highest estimations of u.s. gay population u.s. women estimate that about three in 10 americans (29.7%) are gay or lesbian the highest of any key subgroup, and much higher than men's perceptions (17.4%). Drawing on information from four recent national and two state level population based surveys, the analyses suggest that there are more than 8 million adults in the us who are lesbian, gay, or bisexual, comprising 3.5% of the adult population. of men, 2.2% identify as gay and an additional 1.4% as bisexual.
How Many Adults In The Us
Population aged 65 and above in the netherlands 2009 2019, by age group; number of people from north america living in kuwait 2011 2017; number of people from australia and pacific countries. The first united states census in 1790 classed residents as "free white" people (divided by age and sex), "all other free persons" (reported by sex and color), and "slaves". the 2000 census officially recognized six racial categories including people of two or more races; a category called "some other race" was also used in the census and other surveys, but is not official. Current population survey (cps) data, 2019 annual averages. There was large between state variability in flu vaccination coverage among adults, ranging from 33.9% in nevada to 56.3% in rhode island ().see the interactive fluvaxview application for additional state level estimates by age groups and multiple flu seasons. of the ten states with the lowest influenza vaccination coverage for children in 2018–19, eight were also among the ten states with.