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Alkaptonuria (AKU) (sometimes spelled alcaptonuria) is a disorder in which a substance called homogentisic acid (HGA) accumulates in cells and connective tissues throughout the body. Large amounts of HGA also are excreted in the urine. In a process known as ochronosis, deposits of HGA form dark pigments in the skin, joints, and other tissues of the body. Over the long term, ochronosis leads to ochronotic arthritis, which is a painful inflammation and stiffening of the joints. AKU is also known as homogentisic acid oxidase deficiency, ochronosis, alkaptonuria ochronosis, or ochronotic arthritis.
The black urine that characterizes AKU has been recognized throughout history. It sometimes was considered to be a bad omen. The dark pigmentation of ochronosis has been identified in an Egyptian mummy from 1500 B.C.
AKU was one of the first inherited disorders to be identified as a deficiency in a single enzyme in one pathway of the body's metabolism. In 1902, Sir Archibald Garrod, after consultation with the famous geneticist William Bateson, proposed that the inheritance of AKU could best be described by Gregor Mendel's theory of the inheritance of recessive characteristics. These are inherited traits expressed in some of the offspring of parents who both carry the trait. The parents may or may not express the trait. In 1908, Garrod coined the term "inborn error of metabolism" to describe AKU and three other metabolic disorders. Furthermore, he suggested that AKU was due to a deficiency in a specific enzyme, a protein that catalyzes one step of a metabolic pathway.
During normal metabolism, the 20 common amino acids, that are the building blocks of enzymes and other proteins, are broken down into simpler substances. This process provides energy for the body. The amino acids phenylalanine and tyrosine are converted to simpler substances in a series of eight steps. Each step in this pathway
AKU results from a deficiency in an enzyme called homogentisate 1,2-dioxygenase (HGD). This enzyme also is called homogentisic acid oxidase. It is responsible for the fourth step in the breakdown of phenylalanine and tyrosine, the conversion of HGA to 4-maleylacetoacetic acid. When there is a deficiency in active HGD, as in AKU, HGA cannot be broken down further. It accumulates in cells and tissues throughout the body, and large amounts of HGA are excreted in the urine.
Oxygen causes HGA molecules to combine with each other to form a very large molecule called a polymer. This polymer is a dark pigment similar to melanin, the pigment responsible for skin color. This pigment is formed in the tissues of the body, as well as in urine exposed to the oxygen in air. Oxygen can also convert HGA into a toxic substance called benzoquinone acetic acid.
HGA is excreted very quickly. In general, levels of HGA are kept quite low in individuals with AKU. Nevertheless, over time, large quantities of HGA, either as individual molecules or as a polymer, are deposited in the cartilage (the flexible tissue of the joints and other bony structures) and in other connective tissues of the body.
Granules of HGA pigment collect around collagen. This is the protein that makes up the fibers of connective tissues. Collagen is the most abundant protein in the body. It is a major structural component of cartilage, bone, tendons, ligaments, and blood vessels. Collagen also forms an important structural layer beneath the skin, and it holds together the cells of various tissues. The accumulation of HGA in connective tissues interferes with the body's ability to make new collagen. As a result, collagen fibers throughout the body are weakened. In particular, HGA weakens the collagen fibers in the cartilage of the joints.
Most treatment of AKU is directed at the diseased joints. The treatment for ochronosis is the same as for other forms of degenerative arthritis. Treatments include painkillers, physical therapy, rehabilitation, orthopedic supports, and rest. Chiropractic manipulations and exercise regimens also are utilized.
Treatment of ochronotic arthritis eventually may require hip and/or knee joint replacements with artificial materials. In older individuals, fusion of the lumbar discs of the lower spine may be necessary. Aortic valve replacement may be necessary to treat heart disease.
AKU is an autosomal recessive disorder. It is autosomal because the gene encoding the HGD enzyme is located on chromosome 3, rather than on either of the X or Y sex chromosomes. AKU is a recessive trait because it only occurs when an individual has two copies of the defective gene, one inherited from each parent. The two defective HGD genes do not need to carry the same mutations. If the two mutations are identical, the individual is a homozygote. If the two mutations are different, the affected individual is called a compound heterozygote.
In individuals with a single defective HGD gene, at least 50% of the HGD enzyme has normal activity. These individuals have no symptoms of AKU. However, they are carriers of AKU and can pass the gene on to their offspring.
All of the offspring of two parents with AKU will inherit the disorder. All of the offspring of one parent with AKU and one parent with a single defective HGD gene will inherit at least one defective HGD gene. These offspring have a 50% chance of inheriting two defective genes and developing AKU. The offspring of one parent with AKU and one parent with normal HGD genes will inherit a defective gene from the affected parent, but will not develop AKU. The offspring of parents who both carry one defective HGD gene have a 50% chance of inheriting one defective HGD gene. They have an additional 25% chance of inheriting two such genes and developing AKU. Finally, the children of one parent with a single defective HGD gene and one parent with normal HGD genes have a 50% chance of inheriting the defective gene, but will not develop AKU.
A large number of different mutations have been identified in the HGD gene. These changes reduce or destroy the activity of the HGD enzyme. Mutational hot spots have also been identified in the gene. These are regions of the gene in which mutations are particularly likely to occur.
As a recessive disorder, AKU requires two copies of the defective gene, one inherited from each parent. Thus, AKU is much more common in the offspring of couples who are related to each other, such as first or second cousins. As an autosomal disorder, AKU occurs equally among males and females. However, in general, the symptoms of arthritis appear at an earlier age in males and tend to be more severe than in females. The reason for this difference is not known.
AKU occurs with equal frequency among various races; however, the frequency varies substantially among different populations. It is most common in geographically isolated populations. The worldwide prevalence of AKU is estimated at between one in 100,000 and one in 250,000 individuals. However, some estimates are as low as one in a million individuals and, in the United States, AKU frequency is estimated to be only one in four million.
AKU occurs with particularly high frequency in the Dominican Republic, Slovakia, and the Czech Republic. The frequency has been reported to be as high as one in 19,000 live births in Slovakia. The frequency of AKU is particularly low in Finland. Certain mutations occur only in HGD genes from Slovakia. Two specific mutations occur in 50% of all Slovakians with AKU. Other mutations in HGD appear to be unique to the Finnish population.
Often, the first sign of AKU is the dark staining of an infant's diapers from the HGA in the urine. However, a significant number of AKU-affected individuals do not have blackened urine, particularly if their urine is acidic. Other than darkened urine, AKU generally has no symptoms throughout childhood and early adulthood. Nevertheless, pigment is being deposited in the tissues throughout the early years. Occasionally, black ear wax and pigmentation under the arms may develop before the age of 10.
The symptoms of ochronotic arthritis are similar to those of other types of arthritis. However, the large, weight-bearing joints usually are the most affected in ochronotic arthritis. These include the joints of the hips, knees, and shoulders, and between the vertebrae of the spine. The joints become stiff and difficult to move. This arthritis develops at an unusually early age. In unaffected individuals, similar arthritis usually does not develop before age 55. Men with AKU develop arthritis in their 30s and 40s. Women with AKU usually develop arthritis in their 50s.
AKU can lead to osteoarthrosis, a degenerative joint disease, and ochronotic arthropathy, which is characterized by the swelling and enlargement of the bones. Ankylosis, the adhesion of bones in the joints, also may occur. The pigment deposits may cause the cartilage to become brittle and susceptible to fragmenting. Individuals with AKU may be at risk for bone fractures.
Calcium deposits can lead to painful attacks similar to those of gout. This calcification may occur in the ear cartilage and in the lumbar disks of the lower back. The disks between vertebrae may become narrowed and eventually may collapse.
The coronary artery of the heart can become diseased as a result of AKU. The aortic valve of the heart may harden and narrow from calcification. Similar problems may develop with the mitral or left atrioventricular valve of the heart (mitral valvulitis). Deposits of pigment can lead to the formation of hard spots of cholesterol and fat (atherosclerotic plaques) in the arteries. This can put a person at risk for a heart attack.
Complications from the deficiency of the HGD enzyme arise primarily in the kidneys and the liver. HGD normally is most active in the kidneys, liver, small intestine, colon, and prostate. The calcification of the genital and urinary tract may lead to blockages in as many as 60% of individuals with ochronosis. Kidney stones and other kidney diseases may develop. Stones in the urine may occur in middle to late adulthood. Increasingly though, this condition is seen in children with AKU under the age of 15 and even as young as two. In men, pigment deposits may lead to stones in the prostate.
The teeth, the brain and spinal cord, and the endocrine system that produces hormones also may be affected by ochronosis. Breathing may become restricted due to the effects of ochronosis on the joints where the ribs attach to the spine. Deposits of pigment on the ear bones and on the membrane of the inner ear may lead to tinnitus, or ringing of the ears, and hearing problems.
AKU is often detected in early childhood because of the characteristic dark-staining of the urine. In adults, diagnosis usually is made on the basis of joint pain and skin discoloration. Most individuals with AKU have pigment visible in the whites of their eyes by their early 40s.
A family history of AKU helps with the diagnosis. Since many individuals with AKU have no symptoms, siblings of affected individuals should be tested for the disorder.
Identification of HGA
An individual with AKU may excrete as much as 4-8 g of HGA per day in the urine. There are several simple methods to test for HGA in the urine: the addition of sodium hydroxide (an alkali) to the urine will turn it dark; urine with HGA turns black when reacted with iron chloride; and alkaline urine containing HGA blackens photographic paper. In the laboratory, HGA can be identified in the urine using a technique called gas chromatographymass spectroscopy. This technique separates and identifies the components of a mixture.
There are a number of methods for identifying HGA in the blood and tissues. These include procedures for separating HGA from other components of the blood and instruments that can detect the characteristic color of HGA. With AKU, the concentration of HGA in the blood is approximately 40 micromolar, or 40 micromoles of per liter.
With AKU, there usually is visible black staining of cartilage in various body regions, particularly the larynx, trachea (windpipe), and cartilage junctions. Heavy deposits of pigment also occur in the bronchi (the air passages to the lungs). Pigment on the inside and outside of the cells of these tissues can be seen with a microscope.
A skin biopsy, the removal of a small piece of skin, may be used to obtain tissue for examination. The tissue is stained with dyes to reveal the yellowish-brown pigment deposits on the outside of skin cells. Pigment deposits also occur in cells of the endothelium (the thin layer of cells that line blood vessels and other tissues), in the sweat glands, and in the membranes below the skin.
Skeletal x rays
X-ray examination is used to detect calcification of the joints. Since many individuals with AKU do not have dark-staining urine, x-ray evidence of osteoarthritis may indicate a need to test for the presence of HGA in the urine. However, osteoarthritis usually affects the smaller joints; whereas ochronosis most often affects the large joints of the hips and shoulders. Spinal x rays may show dense calcification, degeneration, and fusion of the disks of the vertebrae, particularly in the lumbar region of the lower back. Chest x rays are used to assess damage to the valves of the heart.
Physicians may order computerized tomography (CT) scans of the brain and chest or magnetic resonance imaging (MRI) of affected joints. An electrocardiogram (ECG or EKG) may reveal signs of heart complications resulting from AKU. Kidney problems may be diagnosed by ultrasound, the use of sound waves to obtain images of an organ. Lung function tests and hearing tests may be performed to assess additional complications.
In addition to being a complication of AKU, ochronosis can be acquired. In the past, ochronosis developed from the repeated use of carbolic acid dressings for treating chronic skin ulcers. The prolonged use of the drug quinacrine (atabrine) can cause ochronosis, with pigmentation occurring in many of the same sites as with AKU. Ochronosis can also result from the use of bleaching creams containing hydroquinone. Certain other substances, including phenol, trinitrophenol, quinines, and benzene, can cause ochronosis. However, these forms of ochronosis do not lead to joint disease and, unlike ochronosis from AKU, are reversible.
Treatment and management
The binding of HGA to collagen fibers is irreversible. Treatment of AKU is directed at reducing the deposition of pigment and thereby minimizing arthritis and heart problems in later life.
Often, high doses (about 1 gm per day) of ascorbic acid (vitamin C) are administered to older children and adults with AKU. Ascorbic acid appears to slow the formation of the HGA polymer and decrease the binding of the polymer to connective tissues. Vitamin C reduces the amount of toxic benzoquinone acetic acid in the urine. However, the amount of HGA in the urine does not decrease. Furthermore, vitamin C does not appear to interrupt the progress of the disease.
Sometimes individuals with AKU are placed on lowprotein diets. This limits the intake of phenylalanine and tyrosine from proteins. If the body has lower amounts of phenylalanine and tyrosine to break down, less HGA will be formed. However, both of these amino acids are necessary for making proteins in the body. Furthermore, phenylalanine is an essential amino acid that must be obtained from food, since the human body cannot produce it. Adult males require approximately 2 gm per day of phenylalanine. Phenylalanine also is present in some artificial sweeteners.
Restricting protein intake to no more than the daily protein requirement may be beneficial for children with AKU. Such diets appear to substantially reduce the amount of benzoquinone acetic acid in the urine. In children under the age of 12, low-protein diets significantly reduce the amount of HGA in the urine, as well. However, these diets seem to have little effect on older children and young adults with AKU, and low-protein diets are difficult to maintain. When low-protein diets are prescribed, the levels of amino acids in the blood must be monitored, to assure that there is no deficiency in phenylalanine.
Future drug treatment
The National Institutes of Health are undertaking clinical research studies to better understand the clinical, biochemical, and molecular aspects of AKU. These studies are in preparation for clinical trials of a new drug to treat AKU. It is hoped that this drug will block the production and accumulation of HGA.
There is no cure for AKU. Essentially all individuals with AKU eventually experience arthritic symptoms, particularly arthritis of the hips, knees, and spine. The bone and joint disease may become debilitating by the sixth to eighth decades of life. Furthermore, cardiovascular involvement and ochronotic skin abnormalities are to be expected with AKU.
Despite these difficulties, individuals with AKU have normal life expectancies. Although there is an increased risk of heart attack in later life, most individuals with AKU die of causes unrelated to the disorder.
La Du, B. N. "Alkaptonuria." In The Metabolic and Molecular Bases of Inherited Disease, edited by C. R. Scriver, A. L. Beaudet, W. S. Sly, and D. Valle. New York: McGraw Hill, Inc., 1995, pp. 1371-86.
Titus, G. P., H. A. A. Mueller, S. Rodriguez de Cordoba, M. A. Penalva, and D. E. Timm. "Crystal Structure of Human Homogentisate Dioxygenase." Nature Structural Biology 7, no. 7 (2000): 542-46.
Zatkova, A., D. B. de Bernabe, H. Polakova, M. Zvarik, E. Ferakova, V. Bosak, V. Ferak, L. Kadasi, and S. R. de Cordoba. "High Frequency of Alkaptonuria in Slovakia: Evidence for the Appearance of Multiple Mutations in HGO Involving Different Mutational Hot Spots." American Journal of Human Genetics 6, no. 5 (November 2000): 1333-39.
AKU Hotline. <http://www.goodnet.com/~ee72478/enable/hotline.htm>.
National Heart, Lung, and Blood Institute. PO Box 30105, Bethesda, MD 20824-0105. (301) 592-8573. email@example.com. <http://www.nhlbi.nih.gov>.
National Institute of Child Health and Human Development (NICHD). Patient Recruitment and Public Liaison Office, Building 61, 10 Cloister Court, Bethesda, MD 20892-4754. (800) 411-1222, (301) 594-9774 (TTY), (866) 411-1010 (TTY). firstname.lastname@example.org. <http://clinicalstudies.info.nih.gov/detail/A_2000-CH-0141.html>.
"Alkaptonuria." AKU Database. <http://www.cib.csic.es/~akudb/alkaptonuria.htm>.
Burkhart, Craig G., and Craig Nathaniel Burkhart. "Ochronosis." Dermatology/Metabolic Diseases. 25 July 2000. <http://www.emedicine.com/DERM/topic476.htm>.
"Clinical, Biochemical, and Molecular Investigations into Alkaptonuria." NIH Clinical Research Studies. Protocol Number: 00-CH-0141. (March 10, 2001). <http://clinicalstudies.info.nih.gov/detail/A_2000-CH-0141.html>.
Medical College of Wisconsin Physicians and Clinics. "Alkaptonuria and Ochronosis." HealthLink. (March 18, 1999). <http://healthlink.mcw.edu/content/article/921733488.html>.
Roth, Karl S. "Alkaptonuria." Pediatrics/Genetics and Metabolic Disease. (December 10, 2000). <http://emedicine.com/ped/topic64.htm>.
Margaret Alic, PhD
Table Of Contents
- Homogentisic acid
- Genetic profile
- Early symptoms
- Organ damage
- Visual diagnosis
- Identification of HGA
- Microscopic examination
- Skeletal x rays
- Other procedures
- Acquired ochronosis
- Treatment and management
- Vitamin C
- Dietary restrictions
- Future drug treatment

domain: biology


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For RedEyeThere's a lot to say about Lupe Fiasco's brilliant, searing, heartbreaking track "Jonylah Forever," which he released on Soundcloud three days after the shooting of 6-month-old Jonylah Watkins, whose funeral was Tuesday. The track imagines everything...
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Glendale is poised to make a ban on gun shows on city property officials tonight despite a threat by the National Rifle Assn. to file a legal challenge. A majority of the five-member City Council expressed support for the ban amid strong backing from...
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Original site for Sandy Hook Elementary School Shooting topic gallery.


text: This was the first book in the series. I started reading it from the beginning and can't believe I never put it 'my books'. This was a great introduction to the series. We meet the main characters in a who done it which brings them together. He a suspect. She the detective assigned to the case. Just enough romance but a great murder mystery.

domain: artistic


text:
PODCAST - How Eric Sprott is helping
Sentiment is turning and the market continues to improve for juniors, said Kai Hoffmann, CEO of Oreninc, who spoke to Kitco today.
The index has recently gone quiet, but Hoffmann said signs are improving for more financings.
There's been a lull after the two big September gold shows, and a consequent flurry of deal-making. Hoffmann said activity should pick up again.
Looking forward Hoffmann noted that the Precious Metals Summit in Zurich, which runs in November, has companies that exited the precious metal market now starting to return. Hoffmann said a couple of asset management firms are attending, and they want to meet with companies.
"I think that is a positive. We are just not there yet to get them to buy," said Hoffmann.
Hoffmann notes that legendary mining financier Eric Sprott has been very active, which has been supporting the sector. Hoffmann reported that between May and September of this year Sprott invested a total of C$176.7 million in juniors.
"He is spreading the wealth a little bit," said Hoffmann.
"The money that is going into the sector is positive, and other people see that as a sign of good faith."
Listen to our interview with Kai Hoffmann.

domain: economics


text:
In 2020, Charles Booker made history when he challenged incumbent Mitch McConnell for his seat in the U.S. Senate. Despite a loss, his campaign reached hundreds of thousands of people across the nation and once again brought a spotlight to Kentucky politics, but Booker didn’t stop there. Following the buzz of his Senate campaign, he founded the organization and movement, Hood to the Holler, focused on bringing together Kentuckians across the state to fight for change.
Now with over 50,000 followers across social media and thousands of volunteers, the movement has taken off in a big way. Less than a year after its founding, we sat down with Booker to talk about how Hood to the Holler has grown, what goals he has for 2021, and what might be in store for the future.
For those who are unfamiliar, Booker shed some light behind the mission that drives Hood to the Holler:
“Hood to the Holler is a grassroots based organization that is really focused on empowering people so that we can inspire a new wave of leaders to run for office, boards, and commissions. We can break down the barriers to democracy so that more people are involved in the democratic process and are able to take the lead in their neighborhoods, their block, their holler. The biggest part about it is we are focused on bringing people together and addressing issues of structural inequity, racism, and poverty so that we can form new big coalitions.”
In an interview with Forward Kentucky, Booker reflected on how his days a child in West Louisville motivate him to continue facilitating grassroots organizing throughout the state:
“Hood to the Holler was a rally cry for my run for the U.S. Senate, and I’m from the West End of Louisville, I’m from the hood in Louisville, I grew up in poverty, and lived in one of the poorest zip codes in Kentucky. We wanted to tell this story about how if you can listen to people, connect with folks all over Kentucky, that we’ll see our common bonds and we can organize around that.”
He expressed genuine appreciation for the countless volunteers and organizers that have taken the initiative to get involved with the organization:
“A lot of people that have gotten connected to Hood to the Holler did so because they didn’t feel like their voices mattered or they didn’t know how to get involved and they were inspired because they heard my story and saw someone like them, that comes from the struggle, stepping up to lead in my own right.”
“In spite of what the national media might show and what some of our national politicians might be speaking about, the people of Kentucky are ready for real change and it makes me proud.” he said.
Booker expressed optimism and gratitude for the progress the organization has experienced since its founding last year:
“Things are going really really well with Hood to the Holler. I’m fired up about the momentum that we’re building. We have been telling the story about how Kentuckians — people from all backgrounds, all corners, and all walks of life — can come together and fight for a common purpose of transforming our future, and really breaking down those barriers that divide us. … The response all across Kentucky, all 120 counties, has been incredible.”
“I’ve been absolutely blown away by how fast this organization has grown, and even bigger than that how the movement has grown from regular people taking a stand together. It’s not partisan, it’s not limited by the typical division that you would see with urban and rural areas or black, white, and brown, those who have a lot of money in their pocket and those who don’t have any money. We’ve really been able to show how if we all come together we can do big things.” he stated.
“In the midst of all of the pain around Breonna Taylor and her life being taken from us, folks were organizing all over Kentucky. The fact we were able to help them and train folks on how to communicate on issues and to really take an issue, like what happened to Breonna Taylor, and explain that this happened to a black woman for specific reasons that are unique to her. But when it happened to her, it happened to everybody. We all want to be safe in our homes, so we all have a vested interest in fighting to address the ills in our justice system and how we criminalize communities. To be able to have done that and engage half a million Kentuckians in just a little over three months with a brand new organization was mind blowing.”
During a year that also presented many complications from the coronavirus pandemic, Booker says that challenges have become the fuel for innovation and growth for the organization:
“The challenges with COVID-19 really helped to provide a new unique opportunity to meet people where they are. Even before the pandemic we had a lot of barriers and walls built up that blocked regular folks out of the democratic process, or that blocked folks out of being able to lead for change in their community. I think the pandemic in-and-of-itself really helped to expose that fact that we can’t keep ignoring folks. That we have to think outside the box and we have to push ourselves to connect and build coalitions together because we need one another.”
“We were really leaning into ways to make organizing easier, using social media, a lot of folks have a phone, even if the internet is crappy. How can you start to engage your family, your friends, using relational organizing. So, the pandemic really showed the value of doing that type of work.” he told Forward Kentucky.
“Over the course of the year coming out of my primary and when I founded this organization, we kept doing digital organizer training. We had started the summer with around 6,000 folks that signed up to volunteer because they wanted to learn how to be an organizer in their community. They wanted to figure out ways to take the lead for themselves, a lot of folks were protesting and demonstrating because they wanted to see real change. This was a way to say: how do we turn those protests into policy change?”
Digital organizer trainings proved to be a success, and Hood to the Holler continued to have a reliable stream of volunteers ready to put in the work throughout the year:
“Every week through the summer and through the rest of the year we did these digital organizer trainings, relational organizing trainings, and then we deployed folks to use that to register voters, to educate folks on various issues, like no-knock warrants.”
For Booker, the work has more than paid off: “In the last quarter of the year we engaged half-a-million Kentuckians using person-to-person outreach.”
In the upcoming year, Booker says the organization has set high goals, further building on a passion for change that Kentuckians have had since former Governor Matt Bevin was in office:
“We definitely have some big goals; the organization is not yet a year old, so it really does speak to the story that I was able to lift up in my own rights, and also just the energy and excitement that Kentuckians have been building on for years. Even when teachers were going into the Capitol saying, we’re not going to take it, standing up for our children and our future.”
“What we’re really trying to do this year, because those trainings were so well received and people were so excited about them, we want to build that into an annual training and do that multiple times per year. We are working with Arena to build that and tailor it to Kentucky.” he stated.
Arena, a national organization devoted to political organizing, hosts intensive five-day training sessions where citizens can develop the skills they need to organize within their communities. The national partnership with Arena could have an unmeasurable impact on the longevity of the organization, says Booker: “They have these academies they do nationally, they have never come to Kentucky before, and they reached out to me because they saw what we were doing, we were training folks, and we had trained several thousand volunteers who then were training folks.”
“When Arena reached out to us and offered the chance to partner on creating a political academy to help folks from the forgotten places, underserved marginalized communities, to get access to this training that’s typically several hundred dollars, we were able to provide it for free and had 280 folks in our first class. The largest one that Arena has ever done. We had thousands of applications from across Kentucky. And it was a five day training that was really intensive and we’re actually doing another one … because the excitement was so great and so it’s just an example of the appetite Kentuckians have for leading for change themselves. And I’m just really excited that Hood to the Holler can help be a part of it.”
The goal is to form coalitions among citizens and organizations alike, building a strong network of change-driven individuals who want to see progress in their communities:
“Our aim is to train 25,000 ambassadors on how to uplift support and drive voter engagement in their community, so 25,000 new voices. The aim is that they will then have the capacity to train others. … We’re partnering with a lot of these organizations like Kentuckians for the Commonwealth and People’s Campaign, ACLU – there’s a lot of folks across Kentucky that are already doing great work in urban and rural communities. If we partner together, we can turn this into something that happens all the time, where democracy is taking place all the time.”
He is adamant on establishing Hood to the Holler as an integral part of the Kentucky political scene: “We just launched a voter registration campaign that’s a statewide campaign on getting folks registered, updating their registration, and engaging folks in the democratic process during an off year. Our aim is we are building out a three-year plan for this.”
Booker stated that he and others would like to see change in the Commonwealth take place sooner rather than later, reflecting on community organizing taking place in other states, such as Georgia. “I’ve talked to Stacey Abhrams about this project, and she’s fired up about what we’re doing in Kentucky.” he stated.
Beyond wide-scale voter registration, he revealed that the organization is taking big steps towards ensuring their stability as an organizing force in the state through producing training materials:
“We’re also building a lobbyist training and resource guide that will be online and in print so that we can have more folks be advocates in local government, state government, and federal government. So this year is a really big foundational year for us to build out, so that this can be a long term value add to Kentucky.”
“Hood to the Holler is an organization that is focused on activating people, we’re looking to create programming so that we can stay around for a long time. We just want to inspire more people to lead themselves and help give them the tools they need to do it.” he stated.
“Our aim is if we can activate more folks that never thought they could get involved, didn’t know how, didn’t know what to do, that they can plug into organizations that exist and help the work go to the next level or they can create their own new thing. So ultimately, the big picture, that’s what we’re trying to do. I think the fact that it’s non-partisan gives us a chance to speak to a bigger audience and build some new coalitions that I think can help transform politics in Kentucky.”
He told Forward Kentucky that Hood to the Holler is a culmination of his life’s work: “This has been my vision. It’s why I went to the state House, it’s why I’ve worked in every level of government, and why I ran for Senate.”
Booker is still considering another run for Senate in 2022, this time taking on incumbent Rand Paul. With the deadline to announce his candidacy quickly approaching, he stated that there are big things coming.

domain: politics


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The harsh lessons learnt from the last Commonwealth games in New Delhi, relating to time and cost overruns, and charges of large-scale corruption, has redefined the manner in which the Commonwealth games federation approaches issues of infrastructure building ahead of the games, members of the evaluation committee of the CGF have said.
An evaluation committee from the Commonwealth Games Secretariat has arrived here to examine, over the next four days, the bid documents and assess the venues that Sri Lanka intends to build for the 2018 Commonwealth games in Hambantota. Two cities in the race to host the 2018 games – the other is Gold Coast, Australia. The games federation has made it clear that its process would be “fair and transparent.”
This is the first evaluation of host cities after the conduct of the 2010 games. The evaluation of the 2014 Glasgow games was held much ahead, and the selection of the venue was announced in Colombo in 2007.
Asked what lessons the Commonwealth games federation took home from New Delhi 2010, CGF chief executive Mike Hooper said: “We will be putting in place mechanisms to ensure that we don’t see similar accounts occur. Every one knows and it’s a matter of public record the number of construction delays in India and in Delhi. Targets came and went and I remember speaking about it very many times in Delhi myself. So I think it really comes down to the oversight process we ourselves put in place.”
Hence, regardless of which city wins the race to host the next games, the CGF is very clear that deadlines will have to be kept. “We will be discussing that with whoever is the successful candidate and ensuring that whatever is put in place is appropriate. Indeed the commitments that have been given, for example, in this candidature, the [Sri Lankan Sports] Minister [Mahindananda Aluthgamage] today and the chairman of the bids committee [Ajith Nivard Cabraal] are very clear that we are not going to see those kinds of issues coming up. We are going to have our facilities and infrastructure in place by 2016,” he added.
Ahead of this, the CGF is now concentrating on examining the bids with a fine comb. “Our role is to undertake a detailed technical review of the bids…and publish it one month ahead of the commonwealth general assembly …The technical merits of the bid is the most important. That makes this process very important,” Louise Martin, Common Wealth Games Evaluating Committee chair, told presspersons here on Monday.
The member countries vote to decide if the games will come back to Asia one more time, or will be held in Australia for a fifth time. Australia is among the four nations that have hosted 17 out of the 20 games held so far.
The head of the Hambantota 2018 organising committee chairman and governor of the Central Bank of Sri Lanka Ajith Nivard Cabraal said that Sri Lanka had chalked out a plan to avoid time overruns and had also given an assurance to this effect to the games federation.
Keywords: Commonwealth games

domain: news


Welcome music lovers and aspiring pianists! Are you searching for skilled and affordable pianist lessons in Fairmont, West Virginia? If yes, then you have come to the right place! Learning how to play the piano is an exciting experience that requires determination, patience, and consistent practice. By taking professional instruction, you can develop your piano skills and make progress toward your musical goals.
Whether you are a newbie or an advanced player, it’s important to choose the right piano teacher who can provide personalized instruction tailored to your needs, strengths, and weaknesses. This article provides valuable tips on selecting the best piano lessons in Fairmont, West Virginia, and how to improve your piano playing abilities.
The Importance of Quality Piano Lessons
Learning Proper Technique
When learning to play the piano, it is crucial to receive quality piano lessons through experienced instructors who can teach you proper technique. Proper technique involves sitting posture, hand and finger placement, and correct playing technique that will result in better sound production and a reduced risk of injury.
The right posture is essential when playing the piano, as it helps to maintain balance and reduce tension. Therefore, your instructor will teach you how to sit straight with your feet touching the ground and aligning your elbows and wrists with the keyboard. Additionally, proper hand and finger placement involve positioning your hands and fingers in a way that ensures the most efficient and accurate playing possible.
By mastering proper technique, you can improve your piano playing, and your music will sound more beautiful and impressive. Moreover, it will reduce the risk of injury, such as hand, wrist, or arm pain, which commonly occurs due to improper technique in piano playing.
Besides mastering proper technique, a quality piano instructor can help you develop your musicality and improve your ability to interpret and convey emotions through your piano playing. Musicality refers to the artistic quality that a musician brings to a piece of music, making it more expressive and emotional.
With quality piano lessons, you will be able to learn how to read and interpret music accurately. This skill is essential for developing your musical interpretation, allowing you to convey the right emotions in your playing. Moreover, as your instructor teaches you various musical pieces, they will also guide you on how to bring out the nuances of each piece to make it sound genuine and expressive.
In essence, musicality is what distinguishes mediocre piano playing from excellent piano playing. With quality piano lessons, you can strengthen your musicality and take your piano playing to the next level, leaving a lasting impression on your audience.
A quality piano instructor offers personalized lesson plans tailored to meet your unique needs, abilities, and goals. Unlike online tutorials that often take a one-size-fits-all approach, a quality instructor can adapt to your individual pace and provide the necessary motivation to help you progress efficiently. They will ensure that you remain motivated and continuously improve while simultaneously having fun.
Your instructor will regularly give you feedback and help you identify areas to improve, making it easy to track your progress and evaluate your growth over time. Additionally, they will introduce you to various piano playing styles, such as classical, country, jazz, or pop, depending on your preference and skill level, which widens your playing options and makes piano playing more fun.
Overall, quality piano lessons are the first and most critical step towards becoming a skilled pianist. By choosing an experienced and qualified instructor who offers personalized lessons, you will learn proper technique, develop musicality, and progress efficiently towards your piano playing goals.
Looking for the top pianist lessons in Fairmont, West Virginia? Check out our pianist lessons page to find experienced instructors.
The Best Piano Lesson Providers in Fairmont, West Virginia
Fairmont, West Virginia, is a city that thrives on music. Aspiring pianists who are looking to improve their skills or learn how to play the piano can choose from a variety of quality pianist lessons providers in the area. In this article, we will take a closer look at some of the top pianist lesson providers in Fairmont, West Virginia, that offer individualized attention and personalized lesson plans to help students achieve their musical goals.
Pianist Lesson Provider in Fairmont Music Hall
Fairmont Music Hall is a great place for budding pianists to take lessons. They offer quality piano lessons with experienced instructors who tailor the curriculum to each student’s needs. The instructors at Fairmont Music Hall are known for their individualized lesson plans, which include personalized music theory, sight-reading, and ear-training exercises. With their tips, students can improve their techniques and gain confidence in their piano-playing abilities.
In addition to providing one-on-one lessons, they also facilitate various music competitions and performances. This offers students the opportunity to showcase their talent while learning valuable lessons from music experts. Students can also join other musicians in Fairmont Music Hall’s music community, which is a great way to network and build relationships with other passionate performers.
To get started, all you need to do is contact them at (123)456-7890 or visit their location at 123 Main St., Fairmont, WV. Prices start at $50 per hour.
Pianist Lesson Provider in Music Go Round
Music Go Round is a popular music store that offers a range of instrument lessons, including piano lessons provided by experienced instructors. They provide a recorded lesson-tracking service that allows students to evaluate their progress from lesson to lesson. This service is perfect for students who want to keep track of their growth and see how much they have progressed since their first piano lesson.
At Music Go Round, students can also choose to learn the songs and music they are passionate about. This creates a unique learning experience that is tailored to each student’s musical preferences. By learning songs they enjoy, students can stay motivated and engaged in the learning process, which can speed up their progress.
If you want to learn piano and get your hands on quality instruments, contact Music Go Round at (234)567-8901 or visit their location at 789 Market St., Fairmont, WV. Prices start at $45 per hour.
Pianist Lesson Provider in West Virginia University School of Music
If you are looking for high-quality piano lessons, the School of Music at West Virginia University is one of the best options in Fairmont, West Virginia. With experienced instructors who tailor the curriculum to each student’s needs, they provide lessons that are challenging yet rewarding.
The School of Music also facilitates various music events and opportunities, giving students the chance to collaborate with other musicians and perform in front of large, appreciative audiences. At the School of Music, students can gain exposure to different music genres and learn from experts who are passionate about music. With their guidance, students can develop their skills and techniques and become the best pianists they can be.
If you are interested in taking piano lessons at the School of Music at West Virginia University, contact them at (345)678-9012 or visit their location at 345 University Ave., Morgantown, WV. Prices start at $70 per hour.
The Bottom Line
Whether you are a serious pianist or someone who wants to learn the basics to play a few songs, the piano lesson providers in Fairmont, West Virginia, have got you covered. Each provider offers a unique approach to piano lessons, which can cater to different learning styles and abilities. With quality instructors who tailor the curriculum to each student’s needs, students can achieve personal growth, build confidence, and become the best pianists they can be.
For comprehensive information on the thriving music scene in Fairmont, West Virginia, read our music scene guide featuring local talent and venues.
The Benefits of Pursuing Piano Lessons to Become a Professional Pianist
It is often said that music is the universal language that transcends cultural barriers and connects people from different walks of life. One of the most popular instruments in the world, the piano is one of the most versatile and expressive instruments that can evoke a range of emotions. In this section, we will discuss the advantages of learning to play the piano professionally and how this can enrich your life.
Ability to Express Emotion through Music
When you learn to play the piano as a professional, you gain the ability to express your emotions more effectively through your music. Music has the power to move people, and being able to communicate your feelings through your piano playing can leave a lasting impression on your audience. As a result, you can experience a sense of fulfillment and achievement that comes with being able to connect with others through your music.
Higher Opportunities for Paid Performances
Playing the piano professionally means that you have higher chances of landing paid performances. Whether you want to perform at weddings, concerts, or other events, you can be sure of earning a good income. Professional pianists can also work as accompanists for different genres, such as pop, jazz, and classical music. This presents a career that is both rewarding and fulfilling, allowing you to put your passion for music to good use.
Improving Your Cognitive Development
Learning to play the piano has been scientifically proven to enhance cognitive development. By regularly practicing, you can improve your memory, spatial reasoning, and problem-solving skills. These cognitive skills can be applied in many areas of life, not just in playing the piano. As a result, pursuing piano lessons can have a positive impact on your overall well-being.
In conclusion, pursuing piano lessons to become a professional pianist not only enriches your life but also offers several advantages. By gaining the ability to express emotion through your music, increased opportunities for paid performances, and boosting your cognitive development, learning to play the piano can be an excellent investment for your career and personal growth.
FAQs About Piano Lessons in Fairmont, West Virginia
Why should I take piano lessons?
Aside from simply learning to play an instrument, there are numerous benefits that come with taking piano lessons. Some of the most significant advantages include:
– Better sound production: Through lessons, you’ll learn how to properly strike keys and produce resonant, clear notes.
– Cognitive development: Learning piano requires a significant amount of focus and attention to detail, which can help improve cognitive skills like memory and problem-solving.
– Emotional expression through music: Playing piano can be a great outlet for emotional expression, allowing you to convey feelings or moods that may be difficult to put into words.
How long does it take to learn piano?
The length of time it takes to learn piano can vary widely based on a few factors:
- Dedication: Like anything, the more time and effort you put into practicing, the quicker you’ll see progress.
- Practice habits: Consistent, daily practice will help you master skills faster than practicing sporadically.
- Natural talent: While anyone can learn piano, some individuals may have a more natural aptitude for it, which can speed up the learning process.
With consistent practice and quality lessons, you may start playing simple pieces after a few months, but mastering the instrument can take years of dedication.
Do I need a piano to take lessons?
While having access to a piano for practice outside of lessons is recommended, it’s not strictly necessary for beginner and intermediate students. Most piano lesson providers will have a piano available for your lessons, and electronic keyboards can suffice for beginners.
Can adults learn piano?
Absolutely. Piano learning is not restricted by age, and it’s never too late to start learning an instrument. In fact, adults may have a few advantages over children when it comes to learning, such as more developed cognitive skills and a better ability to focus.
How do I choose the right piano lesson provider?
When selecting a piano lesson provider, there are a few important factors to consider:
– Instructor’s experience and qualifications: Look for an instructor with a solid background in piano and teaching, as well as any relevant certifications or degrees.
– Lesson curriculum: Make sure the curriculum aligns with your goals, whether you want to play for fun or pursue classical training.
– Location: Consider the location of the lessons in relation to your home or work, especially if you’ll be commuting regularly.
– Price: Piano lessons can range in price based on the provider’s experience, qualifications, and location. Research and compare prices to get an idea of what’s reasonable for your area.
By considering these factors and doing some research, you can find a provider that meets your needs and helps you reach your piano-playing goals.
Can piano lessons be taken online?
Yes, many piano lesson providers offer online lessons that can be taken from the comfort of your own home. Online lessons can be a great option for individuals with busy schedules or those who don’t live near a piano teacher.
What should I bring to my piano lessons?
In addition to any specific materials requested by your teacher, such as a particular lesson book or sheet music, you should also bring:
– A notebook for taking notes during the lesson
– A pencil for marking up music or taking notes
If you’ll be taking lessons at your own piano or keyboard, remember to bring that along with you.
What should I expect in my first piano lesson?
In your first piano lesson, your instructor will likely assess your skill level and introduce you to basic concepts and techniques, such as hand position and posture. You may also work on some simple exercises or pieces to get a feel for the instrument. Don’t worry if you feel overwhelmed or unsure – your teacher will help guide you through the learning process.
How often should I take piano lessons?
It’s generally recommended to take weekly lessons to maintain steady progress and motivation. However, some individuals may choose to take lessons every other week or once a month, depending on their schedule and personal goals.
How much do piano lessons cost?
The cost of piano lessons can vary widely depending on a few factors, including:
– Instructor’s experience and qualifications
– Location of the lessons
– Lesson length and frequency
The average cost for an hour-long lesson in Fairmont, West Virginia, ranges from $40 to $80. Some providers may offer discounts for purchasing multiple lessons upfront or scheduling lessons at a set time each week.
Why Choose Piano Lessons in Fairmont, West Virginia?
Learning how to play the piano is a wonderful activity that offers a wide range of benefits. Whether you’re a beginner, intermediate, or advanced student, there are plenty of reasons to choose piano lessons in Fairmont, West Virginia.
Here are some of the top reasons:
When you choose piano lessons in Fairmont, West Virginia, you can be sure that you’ll be receiving quality instruction from trained professionals. Many piano teachers in the area have years of experience and advanced certifications, so you can rest assured that you’re in good hands.
Another great reason to choose piano lessons in Fairmont, West Virginia is the flexibility. You can choose from a variety of lesson schedules that work best for your busy life.
Many piano lesson providers in Fairmont, West Virginia offer affordable rates, making it easy for anyone to learn how to play the piano. Whether you’re on a tight budget or looking for a great value, there are plenty of quality options in the area.
Finally, choosing piano lessons in Fairmont, West Virginia is a great way to become part of a supportive community of musicians. You’ll have the opportunity to meet other pianists and attend recitals and events in the area.
Choosing the Right Piano Lesson Provider
Now that you know why you should choose piano lessons in Fairmont, West Virginia, it’s time to choose the right provider. Here are some factors to consider when making your decision:
Experience and Qualifications
One of the most important factors to consider is the experience and qualifications of the piano teacher. Look for a teacher who has years of experience and advanced certifications in the field. This ensures that you’re receiving high-quality instruction from a seasoned professional.
When choosing a piano lesson provider, it’s important to consider the location. Look for a provider that is convenient to your home or work, so you don’t have to travel too far for your lessons.
Another important factor to consider is the scheduling options. Look for a provider that offers flexible schedules and can accommodate your busy lifestyle.
Cost and Value
Finally, consider the cost and value of the piano lesson provider. Look for providers that offer affordable rates and provide high-quality instruction. Make sure you’re getting the best value for your money.
Top Piano Lesson Providers in Fairmont, West Virginia
If you’re ready to start your journey towards becoming a professional pianist, consider one of these top piano lesson providers in Fairmont, West Virginia:
1. Fairmont Music Academy
The Fairmont Music Academy is a top provider of piano lessons in the area. They offer flexible scheduling options and quality instruction from trained professionals.
2. The Piano Studio of Fairmont
The Piano Studio of Fairmont is another great option for piano lessons. They offer beginner to advanced lessons and provide a supportive community of musicians.
3. T. J.’s Piano Studio
T. J.’s Piano Studio provides affordable rates and quality instruction for students of all ages and skill levels. They offer flexible scheduling options and a supportive, welcoming environment.
4. Linda’s Piano Studio
Linda’s Piano Studio is a great option for anyone looking for personalized, one-on-one instruction. Linda is a highly qualified teacher with years of experience, and she provides customized lessons to meet your unique needs.
5. Gage Music Studio
The Gage Music Studio provides quality piano lessons and a welcoming, supportive environment for students of all ages. They offer flexible scheduling options and affordable rates, making it easy for anyone to learn how to play the piano.
No matter which piano lesson provider you choose in Fairmont, West Virginia, you can be sure that you’re receiving quality instruction from trained professionals. So why wait? Register for lessons today and start your journey towards becoming a professional pianist!
Interested in becoming a pianist? Explore our become a pianist guide for tips and advice on starting your musical journey.
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Fitness week of Audi’s DTM campaigners in Lanzarote
Robin Frijns to become Nico Müller’s teammate
DTM Champion René Rast would like to keep “lucky number 33”
Neuburg a.d. Donau –
Winter in Germany, sun on the Canary Islands: In Lanzarote, Audi’s DTM campaigners prepared for the new DTM season in optimum outdoor conditions. In addition, the officials determined which driver is going to race for which Audi team in 2018.
Swimming, strength training, running, cycling and plenty of fun: Under the direction of Le Mans record winner Tom Kristensen and supervision of team physician Dr. Vincenzo Tota, the six DTM drivers spent a week of training involving a large variety of activities. Together with their fellow drivers from Formula E, the team principals and Head of Audi Motorsport Dieter Gass they traveled to Club La Santa in Lanzarote, a facility which is popular as a training camp with professional athletes from around the world. Audi also used the week to bind the DTM team together before the new season. “Team spirit has always been one of our greatest fortes,” says Dieter Gass. “We’ll continue to count on this strength in the future.”
Which Audi driver will be racing in which team in the 2018 DTM, following last year’s successful season, had not been decided before their joint week in Lanzarote. Audi opted for consistency in this respect. “No doubt, the motto ‘never change a winning team’ is not a new one,” says Gass. “When you clinch all three DTM titles plus the top four spots in the drivers’ classification there’s really no reason to change everything. That’s why our rookie, Robin Frijns, will take over Mattias Ekström’s cockpit at ABT. The two other driver pairings at Phoenix and Rosberg will remain unchanged. I’m convinced that we’re perfectly set this way for the title defense in the DTM.”
As a result, the Dutchman Robin Frijns will be the new teammate of the Swiss Nico Müller in Audi Sport Team Abt Sportsline. The two 26-year-olds form the youngest Audi driver duo in the DTM although Müller, with 64 DTM races under his belt, is almost an old hand.
Racing for Audi Sport Team Phoenix will be the German Mike Rockenfeller, the 2013 DTM Champion, and the Frenchman Loïc Duval, who is tackling his second DTM season in 2018.
Audi Sport Team Rosberg continues to be made up of Jamie Green, who moved back from Monaco to his native United Kingdom this winter, and title defender René Rast. In the 2018 DTM, the German, instead of driving car number 1 of the reigning champion, would like to continue driving car number 33, the number he won the DTM title with as a rookie last year. “I like 33 and it brought me luck,” says Rast.
Green and Rast are going to participate in the first pre-season tests in the 2018 version of the Audi RS 5 DTM at Vallelunga from March 1 to 3. In the final pre-season test at Hockenheim from April 9 to 12, all six Audi drivers will be on track before, on May 5 and 6, the new season kicks off at the Hockenheimring as well.
A total of 20 races at ten events in Austria, Germany, Hungary, Italy, the Netherlands and the United Kingdom are scheduled this year. Ticket sales have begun at www.dtm.com/tickets. In Germany, SAT.1 will broadcast all races.
The Audi teams in the 2018 DTM
Audi Sport Team Abt Sportsline #4 Robin Frijns (NL)
#51 Nico Müller (CH)
Audi Sport Team Phoenix #77 Loïc Duval (F)
#99 Mike Rockenfeller (D)
Audi Sport Team Rosberg #33* René Rast (D)
#53 Jamie Green (GB)
* Car number subject to approval by DTM commission


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The December 2016 issue (Volume 96, Number 4) of the Canadian Journal of Animal Science is now online.
Access the December Table of Contents.
The December issue also includes Summaries of Communications of the 2016 Meeting of the Animal Science Modelling Group, Salt Lake Marriott Downtown, Salt Lake City, Utah, 19 July 2016.
Access Just-IN articles.
See e-First articles.
Visit the CJAS list of archived issues.

domain: library


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Russ Liquid is the future-vintage groove-blasting maestro who has stirred the souls and minds of the electronic music world. Renowned for his ingenious
compositional approach, this cosmic virtuoso imprints a prophetic musical experience on his audiences. He detonates explosive beatscapes, seamlessly
adding flourishes of instrumental color and emotion; all while drawing from an endlessly diverse sonic palette.


Several assistive technologies such as automated bathing machine and autonomous robot to raise patient care quality and productivity were showcased at Changi General Hospital (CGH) last week, Today reported.
The Tutti bathing system includes a wheelchair that can be docked directly into the bathtub, allowing patients with decreased mobility to take private baths. Rimo, meanwhile, is a robot that performs the physical task of going around the wards to facilitate communication between a bed-bound patient and another person such as a friend who lives far away.
Tutti and Rimo were among the 28 projects featured in a two-day showcase by CGH’s Centre for Healthcare Assistive and Robotics Technology (CHART), an event geared toward promoting the use of technologies to ease the workload of nurses and caregivers.
“Improving productivity is a very important priority for the healthcare sector... [We want] to have better patient outcomes, a better work environment for our healthcare workers, and also a better healthcare system that is more sustainable, as our population ages,” said Health Minister Chee Hong Tat during a visit to the CHART showcase.
“We have to bring in ideas and solutions from other sectors…combine them with our medical knowledge and procedures, and see how we can innovate and come out with a good solution,” added Chee.
Other projects on display included robotic transporters, convertible wheelchair beds, autonomous robotic floor scrubbers and cleaners, as well as various rehabilitative gadgets such as the wearable Rapael smart glove and a leg rehabilitation robot for physiotherapy.
Launched last year, CHART has struck partnerships with academic, industry and research institutions to develop healthcare solutions leveraging on robotics and assistive technologies in the areas of patient care, rehabilitation, logistics and operations.
CHART Director Selina Seah emphasised that early adoption of such technologies is necessary in bridging the gap between an increasing demand for healthcare and an inadequate workforce.
“If we do not take the chance now for transformation and improve productivity using enabling technologies, then we will be in a greater need for more nurses in the next 10 to 20 years, which we will not get,” Today quoted Seah. MIMS


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President Barack Obama has joined the 15-or-so million people in the iPad nation. He was recently photographed carrying the iPad with an Apple smart cover.
Last month, the President told Univision’s Jorge Ramos that he owns an iPad, and joked that of course he has his own computer (reportedly a MacBook Pro).
And it seems Obama’s iPad may have come with a presidential perk. A CNN photographer says he saw the president using an iPad in the Oval Office not long after he had dinner with Steve Jobs… way back in February. The iPad 2 wasn’t released until March 11.
It took the tech-savy president a little long to get on-board with the iPad though. Just last May, during a commencement address at Hampton University, Obama said, “With iPods and iPads and Xboxes and PlayStations, none of which I know how to work, information becomes a distraction, a diversion, a form of entertainment rather than a tool of empowerment, rather than the means of emancipation.”
Obama’s history with the iPad continued last October, at a rally in Seattle. Waiting in the audience was Sly Cann, who got Obama to autograph his iPad screen.
Obama’s use of the iPad makes sense, as he is truly a president of the 21st century. He is the first sitting president to regularly use email (Bill Clinton sent two emails in office, George W. Bush sent none) or a smartphone (his beloved, specially secure BlackBerry), he tweets (to over 7.5 million followers) and his Facebook page has over 19 million fans.
Download the free Appolicious for iPad app


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*EURweb associate Morris O’Kelly has spoken with Sharon Song Byrd, the Los Angeles woman who has won asexual harassment court case against Al Sharpton associate Tony Wafford. To say her story is a doozy would be an understatement.
Sharon Song Byrd is still very much uncomfortable discussing the details behind what led up to her successful lawsuit against Tony Wafford of the National Action Network.
In close to three hours of conversation, Song Byrd recounted at length and great detail her fear of Wafford showing up at her house at all hours of the night, throwing rocks at her window and an overall inability to accept the fact that his advances were unwanted.
In fact, Song Byrd is still skittish about letting any man know where she lives and requested our conversation be on neutral ground.
So please excuse the sounds of the passing traffic and cooling fans. This was not a typical studio conversation and Song Byrd’s story is anything but typical. Although a similar request was made to Tony Wafford to hear his side on these issues, the request went unanswered.
From evidence concerning questionable accounting and employment practices designed to avoid paying payroll taxes, to extensive police reports and a book’s worth of instant messages printed as proof of a rapport … Song Byrd’s record keeping is exceptional. It would take the average person weeks to effectively comb through and digest all of her material, despite its neat and orderly presentation.
The story thus far has centered around Song Byrd, Wafford and Sharpton, but it is also worthy of mention that it should also include Wafford’s friend and confidante Democratic California Congresswoman Maxine Waters, who went so far as taking then Senator and presidential candidate Hillary Clinton to Wafford’s home, even though Wafford was in the midst of a sexual harassment and battery lawsuit.
Let’s not be naïve, Waters would likely claim ignorance (as does Sharpton) concerning these issues as they were transpiring, but unlike Sharpton she has had offered nothing publicly on these issues since the story broke.
Let’s not be naïve but let’s also be clear.
Congresswoman Waters having nothing to say in the wake of the mistreatment and abuse of an African-American woman in her own backyard says volumes. For all the talk of Sharpton, there should be some concerning Waters too.
It is voluminous, precise and formidable.


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domain: design


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I'm 18+2 with my first, and the last 3 to 4 weeks, I have had really bad nerve pain in my leg. I thought maybe it would go away, but it seems to be getting worse/more frequent. My OB said that it's an unusual symptom for pregnancy and wants to refer me to a neurologist.
From what I've read, the nerve pain is fairly normal and some had said they found relief with from a chiropractor. My OB never mentioned a chiropractor and obviously I don't want to do anything that would hurt the baby.
Has anyone gone to the chiropractor for nerve pain and gotten relief? Thanks in advance!
i had that last pregnancy from
week 18 - on (waiting to see if it pops up again)! after i had the baby i got MRIs of my pelvis and spine and the problem was a herniated disk in my lower back, causing the nerve pain in my left hip and down my left leg.
anyway, i wasnt sure what it was from while i was pregnant and i couldnt take ibuprofen or anything useful like that so i went to the chiropractor about twice a week from weeks 20-40. when i started going i was so bad off i couldnt walk and thought i may need a wheelchair but the chiro visits kept things tolerable. it didnt go away completely but it def offered relief. i hadnt been to a chiro before that so i was nervous about it. i will go back if it comes up again this pregnancy.
I haven't had any issues but one of my girlfriends saw a chiro throughout most of her pregnancy and really recommended it if I need some adjustment towards the end. She even took her newborn once or twice. It may be covered under your insurance so worth looking into for some relief!

domain: medical


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NOTE: The Lighthouse grounds are now open weekends from 10:30 to 3:30, weather permitting. Please consult our facebook page for weather updates.
200 FEET OF LAND LOST IN 200 YEARS
The planners of the Montauk Point Lighthouse were well aware of erosion. The governments agents noted that “Montauk Point is washed by the sea in storms” and “wastes very fast”. They erected the lighthouse at the extreme west end of the Turtle Hill plateau, at a distance of approximately 300 feet from the bluff.
Over the past 200 years approximately 200′ feet of Montauk Point was washed into the Atlantic Ocean. Today the lighthouse stands less than 100 feet from the edge of the bluff.

domain: geography


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Move the Pin is an interesting and fun game that can fill your free time. On the playing field you will see a container in which colorful balls are closed. You will need to open the bowl and let the balls fall into the other empty bowl at the bottom. A condition to move to the next more difficult level is to fill the empty container 100%. Kids, enjoy this puzzle.
Use mouse or touch on the screen!

domain: game


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Wednesday, October 31, 2007
Trick or Freak?! Happy Halloween!
The sad part is, this really didn't require much of a costume. And I am totally wearing this to work today.
Free dental floss to anyone who can accurately guess what Megan and Rose are suppose to be!!!
I kid you not, at this Halloween party on Saturday, strangers actually asked to take pictures with us. How creepy/incredibly SAD is that??!?!
The question on everyone's mind..."Where did you get the braces???!"
Posted by Steph & Steve G at 3:06 AM

domain: entertainment


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Professor Emeritus Douglas Hay was cross-appointed to Osgoode Hall Law School and York’s Department of History in 1981, teaching the comparative history of criminal procedure, punishment, and crime, and the history of private law in the common law world. He was co- director of an international project on the evolution of the contract of employment: Hay and Craven, Masters, Servants and Magistrates in Britain and the Empire, 1562-1955 (2004) and other titles, most recently ‘Working Time, Dinner Time, Serving Time: Labour and Law in Industrialization’ in Law With Class: Essays Inspired by the Work of Harry Glasbeek (2019) and ‘The Master and Servant Statute of 1823: Enlarging the Powers of Justices Act’, Historical Studies in Industrial Relations, 43 (2022), 3-23.
Other work includes the English high court’s criminal jurisdiction (Criminal Cases on the Crown Side of King’s Bench 1740-1800 (2010); ‘Hanging and the English Judges: The Judicial Politics of Retention and Abolition,’ in America’s Death Penalty: Between Past and Present (2010); D. Hay, P. Linebaugh, E.P. Thompson (eds.), Albion’s Fatal Tree: Crime and Society in Eighteenth-Century England (2nd edition, with new introductions, 2011); ‘E.P. Thompson and the Rule of Law: Qualifying the Unqualified Good’, in The Cambridge Companion to the Rule of Law (2021), 202-220; and the ‘Preface’ to the concluding volume of Canadian State Trials, vol.5 (2022).
Professor Hay is presently writing about the administration of the criminal law in Georgian England, the role of the judiciary in King’s Bench, and the comparative history of criminal procedure in the British Empire. He has published books and articles on the history of English and Quebec criminal law; history of criminal procedure; social history of crime; judicial biography; courts and their political significance; and the history of employment law. He has been a visitor at Yale, Warwick, and Columbia law schools, and has been on the boards of the Canadian Historical Review, Law and History Review, the Law and Society Association, and the American Society for Legal History. He has given the Chorley Lecture (London School of Economics), the Iredell Lecture in Legal History (University of Lancaster), The Hugh Alan Maclean Lecture (University of Victoria Faculty of Law), the Weir Memorial Lecture (University of Alberta School of Law), the Annual Lecture for the American Society of Legal History, the Hugh Fitzpatrick Lecture in Legal Bibliography (Dublin), and the Richard Youard Lecture in Legal History (Oxford University). He was elected an Honorary Fellow of the American Society for Legal History in 2013, and Fellow of the Royal Society of Canada (Social Sciences) in 2016.


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So the other day I had images from this old MTV sitcom called Austin Stories stuck in my head. Did some checking around the web for old images, interviews, etc. and came across this site. Also found out that the DVDs are being sold on eBay by Howard Kremer, one of the creators/stars of the series, so on a lark, I decided to buy a copy. It's run was only 12 episodes, and MTV cancelled it before it went into its second season.
The verdict: I'd put it in the pantheon, the exclusive company of Arrested Development and the Office. Seriously, it's that good. It's quirky, intelligent humor, which isn't to say it's too highbrow. It just means you have to be kinda smart to appreciate it, which means it wouldn't appeal to roughly 98% of the viewing public, at least not in a world where Two and Half Men is the #1 comedy in the country.
Fortunately, for those of you who were never exposed to this show, Youtube has the first episode in three separate parts. Enjoy. Then go buy the DVDs. You can even get them autographed by Howard.


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Woodstock Police are proud to have a new member working in the community.
WOODSTOCK - Woodstock Police introduced a new member to the force to help with the communities crime prevention.
Shaylynn Jackson is the Special Constable Community Service Officer and is here to educate and get to work with people in the Friendly City. Jackson isn't a stranger to Woodstock as she's done work with Big Brother's Big Sister's in the past and has lived in the city for some time. She had this to say on her role in the community.
"I am able to work closely with the community prevention and to be in schools running crime prevention, programming, teaching kids about internet safety, drug awareness and peer to peer awareness."
She also wanted to say that she's been in Woodstock for a while.
"So I'm very familiar with this community, I've previously worked in Big Brother's Big Sister's as a case worker, as well as fundraising and marketing and an assistant there. I've done a lot of work in the community, I have a lot of relationships with community partners that I work with now in this role with the Police Service."
She will be out and about in the community so if you see her then feel free to ask questions about crime prevention.

domain: sociology


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These homemade caramel apples feature a tasty from-scratch caramel recipe, lots of tips for success in apple decorating and apple dipping, as well as a free printable caramel apple gift tag. This is your go-to post for candy apple making!
Secrets for perfect homemade caramel apples. These must-read tips will teach you how to prevent the caramel from sliding right off the apple and how to prevent bubbles in the caramel. Plus, I share a delictible caramel recipe perfect for dipping apples!

domain: food


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The Debtors’ overzealous efforts to obtain the Unsecured Term Loan Lenders’ support for the Equity Holder Settlement has resulted in the proposal of a Plan that is patently unconfirmable as it relates to NWHI. The Plan seeks to bully certain NWHI unsecured creditors by deducting all confirmation-related expenses from such creditors’ already paltry recoveries. Of course, the Plan carves out the Unsecured Term Loan Lenders from this indefensible provision, so their inflated recoveries will not be diminished by confirmation-related expenses. The Debtors have not and cannot identify any legal basis for charging NWHI—let alone a disfavored subset of NWHI’s unsecured creditors—for all expenses associated with confirmation of a Plan that principally benefits NWHI’s subsidiaries and those subsidiaries’ creditors to the detriment of NWHI…. The Plan, as it relates to NWHI, further violates section 1129(b) of the Bankruptcy Code by unfairly discriminating against NWHI’s unsecured creditors other than the Unsecured Term Loan Lenders in multiple respects. In addition to burdening only a subset of NWHI’s unsecured creditors with the confirmation-related expenses, the Plan also provides the Unsecured Term Loan Lenders with 92.5% of the non-cash consideration from the Equity Holders Settlement. This favored treatment for the Unsecured Term Loan Lenders may have been part of the price for getting their support for the Plan, but it cannot be justified under the Bankruptcy Code.”
Read more Bankruptcy News
The post Nine West Holdings – Ad Hoc Committee of Unsecured Noteholders Objects to Disclosure Statement, Cites “Grossly Inadequate Consideration” of Sycamore Settlement appeared first on Daily Bankrupt Company Updates | Bankrupt Company News.

domain: law


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We partnered with UC San Diego Athletics to increase movement and physical activity during class time for San Diego Unified students. Increased Movement and Physical Activity in Class Time, known as IMPACT, aims to keep local elementary students active despite the lack of recess and physical education classes in some schools, particularly in underserved areas of San Diego. UC San Diego student-athletes volunteer their time to lead engaging exercise circuits each week, assisting and cheering on the students as they rotate through various stations designed to raise their heart rates and make physical activity fun.
IMPACT was created to address the lack of funding for physical education programs in schools and help students meet fitness standards. By setting up a variety of circuits that include jump ropes, hula-hoops, monkey bars, and stretching exercises, UC San Diego student-athletes actively engage with the elementary students, encouraging them to maintain an active lifestyle. Through their involvement in the program, these young athletes demonstrate the importance of hard work and dedication to achieving athletic goals, while emphasizing the first step of being physically active. The success of the program at Edison Elementary led to its expansion to Toler Elementary, with plans to implement it in more schools in the future. Principals and teachers have already witnessed improved student focus and concentration as a result of the program, indicating its positive impact on the young participants.
Since our initial pilot, IMPACT has been fully adopted and integrated into San Diego Unified School District’s curriculum. Read more about it here.
Click here for news about IMPACT:

domain: health


I was very moved by indigenous rights activist Ryan Bellerose's op-ed in the Toronto Sun denouncing some pro-Palestinian activists' exploitation of First Nations' struggles. As Bellerose astutely put it: "to claim the Jews are colonizers in the Holy Land delegitimizes all indigenous peoples because such attempts trivialize the unbreakable, maternal ties to the land that make us, like the Jews, indigenous." But the solidarity should not end there. Sympathy, however heartfelt, is insufficient.
The situation Canadian Natives face is not befitting of Canadians' genuine compassion and sense of fairness. But Canadian Jews have, like American Jews during the civil rights struggle, a special duty born of shared experience to actively support First Nations' efforts "to be a free people in their own land" (from the Israeli anthem). That duty need not translate to the promotion of any specific politics; Natives must decide for themselves how they wish to fit within the Canadian framework. But it is a duty to help them fight for greater justice, especially when what natives face today so closely resembles our own, past struggles. Their fight is every Canadian's fight but it is ours in particular.
The disparity that First nations suffer is unacceptable. Aboriginal peoples in Canada face sub-par education, employment, economic well-being, health and housing. Aboriginal Canadians earn less than other Canadians, and are at much greater risk of suffering violent crimes or sexual abuse. They are also more likely to be imprisoned.
While Native Canadians are protected by law and their segregation is not entirely imposed, the situation in reserves is far too akin to yesterday's shtetls, ghettos and mellahs to leave us indifferent. Natives have been relegated to the forgotten margins of daily life and Canadian geography, cast aside to witness the world progress without their full participation. That experience is seared in every Jewish memory.
But it is all the worse when considering that Natives are suffering this injustice at home. They did not immigrate to Canada to flee difficulties or seek a better life. Rather, on a land with which they have intimate, millennial ties, Natives find themselves displaced, colonized, and living as second class citizens with much less rights in practice than newcomers.
This is exactly the indignity that the Jewish people suffered in the Holy Land under Roman, Arabian and Turkish occupiers. And like Jews, Native peoples can be credited for not letting their suffering translate to canonized violence or the cultivation of resentment. Like Jews through the ages, it is Natives' meekness that characterizes their struggle; their silence has Hebrew accents.
Jewish experience can serve as a guide (and already has, e.g., to the Navajo). Jews have preserved an ancient culture through displacement and persecution and turned it into a thriving democracy. We have revived an ancient language and made barren soil feed people. But we have much to learn as well. For one, Natives' sacred ties to the land remain the most intimate and respectful of all, and a necessary source of instruction for us.
Jews have always sought to benefit others as part of their DNA. Israel has fought hunger in Africa and helped the vulnerable from Haiti to Turkey to Sri Lanka. It is time for us in North America to play a greater role in First Nations struggles. In helping Natives achieve equality in Canada, we too should be idle no more.


This is an automatic corrugated pipe cutting machine with visual positioning function. Some corrugated tubes must be cut off at specified joints (as the picture shows), so visual inspection function is required to accurately locate the cutting position.
It can also be used to cut ordinary corrugated pipes, and can be accurately cut from the crest or trough position by purchasing an optional jig. The positioning fixture needs to be customized according to the sample, and different products require different fixtures.
The optional longitudinal slitting function of the corrugated pipe can also be selected, then the corrugated pipe can be longitudinally cut while cutting to a fixed length.
Note: Conforms to the relevant CE directives on machine safety and electromagnetic compatibility.


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Update: E&M Services Billed with Skin Tag/Skin Lesion Procedures Claims Issue
On January 12, 2015, we reported a system issue that resulted in certain claims being processed contrary to our reimbursement policy guidelines.
On January 22, 2015, we began adjusting erroneously denied claims for Evaluation and Management (E&M) services billed by the same provider on the same date of service as a skin tag/skin lesion procedure* if the diagnosis codes assigned to the E&M and for the skin tag/skin lesion procedure were different. All impacted claims finalized between November 1, 2014 and January 16, 2015 will be corrected by the end of February 2015.
We thank you for your patience and we apologize for any inconvenience caused by this system issue.
According to our reimbursement policy, Skin Tags and/or Skin Lesions with E&M, E&M services billed by the same provider as skin tag/skin lesion procedure performed on that same date of service will be considered incidental and will not be eligible for separate reimbursement (even if appended with modifier 25) if the diagnoses submitted for the E&M and for the skin tag/skin lesion procedure are the same.
*Skin tag procedures include CPT® codes 11200 and 11201. Skin lesion procedures include CPT codes 17000, 17003, 17004, 17106, 17107, 17108, 17110, 17111, 17250, 17260, 17261, 17262, 17263, 17264, 17266, 17270, 17271, 17272, 17273, 17274, 17276, 17280, 17281, 17282, 17283, 17284 and 17286.
CPT® is a registered trademark of the American Medical Association.


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Creative #: JC8088-001
Collection: Hulton Archive
Max file size: 3,600 x 2,859 px (30.48 x 24.21 cm) - 300 dpi - 1.81 MB
Similar imagesSearch ResultsSame series
Oriana Stock Photo1960,Black And White,Bright,Cruise Ship,Docks,England,Europe,Gel Effect,Horizontal,Lighting Technique,Nautical Vessel,Night,No People,Outdoors,Photography,Stern,Transportation,UKPhotographer LeeCollection: Hulton Archive The brightly-lit stern of the new P&O Orient liner Oriana, moored at Southampton Dock prior to her maiden voyage to Australia.


Since the corruption arrests of more than a dozen Jersey City officials and political figures came down yesterday, Jersey City has been rife with speculation about the identity of "JC Official 4" - a high ranking Jersey City elected official who turns up prominently in the federal complaint against Deputy Mayor Leona Beldini, city official Ed Cheatam and political consultant Jack Shaw.
The federal complaint mentions what appears to be the indicted officials acting as a middlemen for JC Official 4, taking cash and structuring it to donate to his campaign fund in exchange for his help furthering cooperating witness Solomon Dwek's real estate interests.
PolitickerNJ.com has confirmed that "JC Official 4" is Jersey City Mayor Jerramiah Healy, the Hudson County Democratic Chairman. A source close to the mayor admitted as much, but held that he had done nothing wrong.
JC Official 4 is described in the complaint as "a high-ranking elected official in Jersey City, NJ... (who) was seeking reelection on or about May 12, 2009."
That JC Official 4 appeared to be Healy was first mentioned by the Jersey City Independent's Jon Whiten yesterday, who noted that the complaint said that Beldini was treasurer for JC Official 4's reelection campaign. In this year's election, Beldini was treasurer only for Mayor Healy's campaign.
According to the complaint, JC Official 4 first met with Dwek on March 13 of this year, along with the three defendants. The complaint does not quote him at that meeting, with only Shaw and Cheatam telling him that Dwek "the CW was ready to develop real estate with JC Official 4's ‘help' and ‘assistance,' and JC Official 4 was further advised by the CW that ‘approvals are key.'"
After JC Official 4 left the meeting, Shaw allegedly told Dwek to make the payments through him, after which Beldini assured him that she and JC Official 4 would "help move" his real estate "approvals" along.
The money was paid to the JC Official 4 campaign through $10,000 in tickets to a fundraiser, according to the complaint. Beldini is quoted telling Dwek that "[w]hat we're trying to do is put money into different funds so we can, when we need it, funnel it back into [JC Official 4's election fund]. Which everybody does."
According to the complaint, Shaw described JC Official 4 as "very happy" with the contribution.
In a meeting with Beldini, Shaw and Cheatam at a Jersey City luncheonette on April 30, Dwek told her that he was applying for a zoning change and did not want it to go to the "bottom" of the pile.
"Beldini responded that she could say ‘one thing' about JC Official 4--JC Official 4 ‘remembered' JC Official 4's "friends," and JC Official 4's word was ‘gold,'" read to the complaint.
The complaint goes on to say that Dwek agreed to make two more payments - one for $10,000 immediately after that day's meeting, and another $10,000 after the election.
"JC Official 4" later showed up to the meeting, where according to the complaint he was told by Cheatam Dwek wanted to be "on top" of the "pile," and that he had given $10,000, planned to give $10,000 after that day's meeting and again after the election.
"JC Official 4 responded, among other things, that hopefully "we" could work "together" and that this would be "mutually beneficial," read the complaint.
After the meeting, outside of the luncheonette, Shaw allegedly told Dwek that everybody was "happy as hell" with the arrangement and accepted $10,000 in cash.
Newark mayor's race: pro-Jeffries independent expenditure group shows donations of $1.3 million, Wall Street ties in ELEC reportNEWARK - Newark First, the independent expenditure group that supports Newark mayoral candidate Shavar Jeffries in the run-up to the May 13 municipal election, has been on the attack lately against Jeffries'...
By HAYTHAM YOUNES As the May 13th election for Paterson officials nears, I've noticed a lot of candidates running using slogans and empty promises as if they weren't around watching Paterson get to where it's at today. I think it's important that... Read More >
"You know what? I'm still Vinny Prieto. I'm still the same guy. This is always a great event — to see people, to talk about business, to hear about issues and concerns." - Assembly Speaker Vinny Prieto (D-32).- The Star-Ledger
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