text:
Mucolipidosis IV – ML IV
For more information please download our Guide to ML IV.
What is Mucolipidosis IV?
Mucolipidosis IV (ML IV) is a rare genetic disorder belonging to a group of disorders known as the lysosomal disorders. It is most commonly seen in Jews of Eastern European background. Other names for this condition include Ganglioside Sialidase Deficiency and Sialolipidosis.
What causes ML IV?
ML IV is a rare inherited metabolic disorder believed to be caused by alterations in a membrane protein due to mutations in the mucolipin-1 gene. This results in the blockage of endocytic transport which is the absorption of materials, for example, into the cell. This prevents the lysosomes forming correctly which results in a storage of complex lipids within the lysosome. This can cause iron deficiency anaemia and the neurodegenerative features seen in ML IV
How is ML IV inherited?
ML IV is an autosomal recessive disease; both parents must carry the same defective gene and each pass this same defective gene to their child. Where both parents are carriers of the ML IV gene there is a 25% (1:4) chance of having an affected child with each pregnancy. There is a 50% (1:2) chance of a child receiving only one copy of the defective gene and therefore being a carrier.
A carrier will not be affected but can pass the defective gene to his/her offspring. The remaining 25% (1:4) will be neither affected nor a carrier. Using information from an affected individual’s DNA, it may be possible to determine whether brothers and sisters are carriers of, or affected by, ML IV. For further information on the inheritance pattern of MPS and Related Diseases contact the MPS Society for a specialist booklet on inheritance

domain: health


text:
Cancer patients are being dropped from their health insurance plans, the “keep your doctor” mantra touted by Obama turned out to be a lie, the website is a disaster, rising healthcare costs are making the Affordable Care Act not so affordable, and the list goes on and on. With so much negative Obamacare coverage in the news, it’s no wonder that one “nonpartisan” group has been given a $1.1 million grant to create a database of success stories (unlike, you know, these).
Over to you, Fox News:
Families USA, which describes itself on its website as a non-profit dedicated to “the achievement of high-quality, affordable health care for all Americans,” received the $1,100,000 grant from the Robert Wood Johnson Foundation Oct. 4.
The grant, which was first reported by CapitolCityProject.com, is meant to help Families USA expand the database of “real people” sharing their stories of enrolling in ObamaCare. Families USA solicits such stories on its website, asking Americans to submit their examples of how they are benefiting from the Affordable Care Act to educate others.
“The best way to do that is to tell your story, giving a real example of the status quo and the impact of change,” the website says.
As one would expect, the group is hardly “nonpartisan.” According to Capitol City Project, the group has close ties to the administration and Enroll America.
With all the negative press and one delay after another being announced, the administration would, I'm sure, desperately welcome such a database. After all, Obama recently said at the Wall Street Journal CEO Summit, “We obviously are going to have to remarket and rebrand,” which he said would be “challenging in this political environment.” But the 'challenge' of doing so may have less to do with the political environment than with the law itself.

domain: sociology


text:
|Name||SAMUEL | 사무엘|
|Full Name||Samuel Kim Arredondo | 사무엘 김 아레돈도|
|Born||January 17, 2002|
|Hometown||Los Angeles, California, USA|
|Nationality||United States of America|
|Height||178cm | 5′-10″|
|Family||Mother, Younger Sister|
|Education||Hanlim Arts School|
School of Performing Arts Seoul (dropout)
Eonbuk Middle School
Almaden Country Day School → The Elementary School attached to Seoul National University of Education
|Years Active||2015 – present|
|Fandom||GARNET | 가넷|
|Official Page||Instagram @its_kimsamuel|
Repackage Album TEENAGER
2nd EP ONE
Digital Single Winter Night
2017 1st Album EYE CANDY
2017 1st EP SIXTEEN
2018 Cross OST Part.2
Latest Music Video
- He changed his stage name from PUNCH to SAMUEL on June 19, 2017.
- He started his training at 11. — YSSCOM Naver Post
- Samuel is a former Pledis Entertainment trainee. He trained with SEVENTEEN.
- He is a Christian.
- Hobbies: plastic modeling, bowling, watching movies — Produce 101 Profile, NewsAde
- Specialties: drums, acrobatics, basketball — Produce 101 Profile, NewsAde
- Chris Brown is his role model. — 170626 Yonhap News
- He does not like mushrooms. — NewsAde
- He started dancing at 7. — CELUV TV VLIVE
- If he had not made it as a singer, he would have become a fashion designer. — NewsAde
- He won the 1theK’s idol dance survival show DANCE WAR.
- Nicknames: Muel, Mel, Sammy
- Color: white — YSSCOM
- Food: budae jjigae (spicy sausage stew) — NewsAde
- Singer: Chris Brown — Fact iN Star
She is Korean.
He is Mexican-American.
He passed away in 2019.
- Younger Sister
Produce 101 Season 2 (2017)
! PLEASE DO NOT COPY AND PASTE THE CONTENT TO OTHER WEBSITES ! DO NOT FORGET TO GIVE CREDIT FOR THE CONTENT !

domain: entertainment


text:
ello and welcome back to another edition of my musical series, based on the music I’m listening to at the time, the music that moves me and the music I showcase on my radio show.
This week I’ve travelled back to the UK to have a look at a band from London. Music from all over the world is great, especially the UK.
Today’s band comes in the guise of a refreshing new Alternative Rock/Indie Rock outfit. All of the current members sing, play their primary instruments alongside playing synthesizers. This band is called Wolf Alice and I hope you enjoy.
The band – originally created as a duo – formed in 2010 and had self-released an EP of the same name, 'Wolf Alice', during the same year. By 2012, the duo had gained more members and their project became a band.
They released their first official EP, 'Blush', a year later with the new line-up. The 'Creature Songs' EP was then released seven months later.
Just over a year later – 13 months to be exact – they released their debut album, My Love is Cool (2015), but it wouldn’t be for another year or two that I would find the band.
This band, even though they have been together for seven years, only came to my attention this year. Their song ‘Silk’ was released on the soundtrack for T2: Trainspotting (2017), although the song was released on their debut album, My Love is Cool.
‘Silk’ was the song that got me into the band, but it was their sophomore album, Visions of a Life (2017), that cemented my fandom.
The following video is taken from their 2017 album. The song is called, ‘Don’t Delete the Kisses’.

domain: artistic


text:
Genetic evaluation of aspects of temperament in Nellore-Angus calves.
Additional Document Info
The objective of this work was to estimate heritability of each of 5 subjectively measured aspects of temperament of cattle and the genetic correlations of pairs of those traits. From 2003 to 2013, Nellore-Angus F2 and F3 calves (n = 1,816) were evaluated for aspects of temperament at an average 259 d of age, which was approximately 2 mo after weaning. Calves were separated from a group and subjectively scored from 1 (calm, good temperament) to 9 (wild, poor temperament) for aggressiveness (willingness to hit an evaluator), nervousness, flightiness, gregariousness (willingness to separate from the group), and a distinct overall score by 4 evaluators. Data were analyzed using threshold and linear models with additive genetic random effects. Two-trait animal models (nonthreshold) included the additive genetic covariance for pairs of traits and were used to estimate additive genetic correlations. Contemporary groups (n = 104) represented calves penned together for evaluation on given evaluation days. Heifers had greater (worse) means for all traits than steers (P < 0.05). The regression of score on age in days was included in final models for flightiness (P = 0.05; -0.006 0.003) and gregariousness (P = 0.025; -0.007 0.003). Estimates of heritability were large (0.51, 0.4, 0.45, 0.49, and 0.47 for aggressiveness, nervousness, flightiness, gregariousness, and overall temperament, respectively; SE = 0.07 for each). The ability to use this methodology to distinctly separate different aspects of calf temperament appeared to be limited, as estimates of additive genetic correlations were near unity for all pairs of traits; estimates of phenotypic correlation ranged from 0.88 0.01 to 0.99 0.002 for pairs of traits. Distinct subsequent analyses indicated a significant negative relationship of 4 of the various temperament scores with weight at weaning (regression coefficients ranged from -0.008 0.002 for nervousness, flightiness, and gregariousness to -0.003 0.002 for aggressiveness). In subsequent analyses, the regression of temperament trait on sequence of evaluation within a pen was highly significant and solutions ranged from 0.05 0.007 for aggressiveness to 0.08 0.007 for all other traits. The apparent large additive genetic variance for any one of these traits may be useful in identification of genes responsible for differences in cattle temperament.

domain: biology


text:
We all have personal demons. Like getting along with a boss, or jump squats. If gluten is yours, keep Bounty Kitchen on your shortlist of brunch spots. It’s a bright all-day cafe that serves excellent gluten-free pancakes with cinnamon butter and fruit compote, as well as egg and vegetable hashes. Order some avocado toast or the braised beef bowl if wheat, oats, rye, and related species are your friends. The place can get pretty busy during the brunch rush, so might have to wait a few minutes for a table.
Where we've featured it
Great places you can basically treat as gluten-free restaurants.
More spots in Queen AnneSee more
Eden Hill Provisions
Eden Hill Provisions is a casual American restaurant in Queen Anne that serves a great burger.
More American spotsSee more
2120 is an upscale restaurant in Belltown with an American menu and giant punch bowl cocktails.
Portage Bay Cafe
When you have to please a big group for brunch, Portage Bay has your back. There are a few around town, but we like South Lake Union best.
Pacific Inn Pub
Pacific Inn is a pub in Fremont that serves delicious fried seafood and has a patio.
Suggested by our writers
Canlis is the most upscale fine dining experience you’ll find in Seattle. Before you commit, here’s a step-by-step breakdown of what you can expect.
Deru Market is part farm-to-table restaurant, part classy deli in Kirkland, and you need their cake.
Seattle Biscuit Company
Seattle Biscuit Company is a Southern spot that serves biscuit breakfasts all day.
Filter and browse restaurants near you
Text us for personalized recommendationsLearn more

domain: food


text:
DALLAS (AP) - Good friends like Willie Nelson and Merle haggard got more credit for their contrary ways and trend-setting ideas, but it was Ray Price who set the precedent for change in country music more than a decade earlier.
CARMEL (AP) - Academy Award-winning actress Joan Fontaine, who found stardom playing naive wives in Alfred Hitchcock's "Suspicion" and "Rebecca" and also was featured in films by Billy Wilder, Fritz Lang and Nicholas Ray, died Sunday. She was 96.
DES MOINES, Iowa (AP) - The Mega Millions jackpot inched toward a U.S. lottery record Monday as it soared to $586 million amid a frenzy of ticket purchases, raising the possibility that the prize could pass the once-unthinkable $1 billion mark by Christmas Eve should nobody win before then.
REGULATORS SUE ONLINE LENDER CASHCALL: WASHINGTON (AP) - Federal regulators have sued online lender CashCall Inc., its owner and two related companies, accusing them of collecting money that consumers didn't owe.
WASHINGTON (AP) - In a ruling with potentially far-reaching consequences, a federal judge declared Monday that the National Security Agency's bulk collection of millions of Americans' telephone records likely violates the U.S. Constitution's ban on unreasonable search. The ruling, filled with blistering criticism of the Obama administration's arguments, is the first of its kind on the controversial program.
NEW HAVEN, Conn. (AP) - President Barack Obama's acknowledgement that his promise that Americans could keep their health insurance plan turned out to be inaccurate topped this year's list of best quotes, according to a Yale University librarian.
SMITHVILLE, Ohio (AP) - A 9-year-old Ohio girl last seen playing in the mobile home park where she lived was found dead in a nearby trash bin after a frantic search, and police on Sunday arrested a neighbor they've described as a family friend in the killing.
DES MOINES, Iowa (AP) - Superstition didn't deter players hoping that Friday the 13th would bring them good luck in the recently revamped Mega Millions game, as heavy sales prompted lottery officials to boost the jackpot from $400 million to $425 million.
WASHINGTON (AP) - One day after winning lopsided House approval, bipartisan legislation to ease across-the-board spending cuts and reduce economy-rattling budget brinkmanship appears likely to command the 60 votes necessary to clear the Senate, officials in both parties said Friday.

domain: news


text:
[ View full size screenshot ]
Version: Calibre 0.8.0
Date: May 11, 2011
|I would recommend downloading this direct from the developer website. But Calibre is by far the best ebook software I've found. It is free, but has better functionality than any paid eBook software I've tried. It's constantly being updated with new features and tweaks. It can convert pretty much any format to any other format, handles sending to almost any device, and can be customized extensively with plugins. Works on windows/mac/linux, though I gather this is the windows installer. Once again, go to the developer website. Google search Calibre Ebook and it is the first result.|
|Version||Date Released||Status||Release Notes|
|Calibre 2.17.0||Jan 26, 2015||New Release||Edit Book: A new reports tool that shows a summary of files, images, words, characters and styles used in the book. The reports tool is a great way to get an overview of the different parts of your book. Every line in the report is hot-linked, double clicking it jumps to the places in the book where that item is used.
Edit Book: Allow adding the 'Manage Snippets' action to the toolbar, for easy access
|Calibre 2.16.0||Jan 10, 2015||New Release||Edit Book: Add support for snippets -- small pieces of text that are often re-used.|
|Calibre 2.13.0||Dec 19, 2014||New Release||Driver for the new CYBOOK MUSE ebook reader
Edit metadata dialog: Allow editing identifiers in a dedicated window by right clicking on the identifiers edit box.
|Calibre 2.12.0||Nov 28, 2014||New Release||Edit Book: Automatically complete the closing tag in HTML/XML files when typing < /
Edit Book: Implement auto-indent, now when pressing the Enter key to start a new line, the new line's indentation is automatically created
Driver for the Verso E71b ebook reader
|Calibre 2.11.0||Nov 21, 2014||New Release||Edit Book: Add a new 'function mode' for the Search and Replace tool
The function mode allows you to create python functions that run on the results of Search and Replace. This allows you to do arbitrarily powerful text processing. For example, you can automatically fix the case of text, automatically add section number to headings, and so on.
|Calibre 2.10.0||Nov 14, 2014||New Release||Driver for the PocketBook Lux 2 with latest firmware.
Review downloaded metadata: Add suggestions for the tags, authors, publishers and series fields. Suggestions will pop-up as you type.
Add Books: Improve performance when adding large numbers of books at once
|Calibre 2.9.0||Nov 7, 2014||New Release||E-book viewer: Show footnotes in a separate popup window
Now when you click on a link to a footnote/endnote, the corresponding note is shown in a separate popup window, for convenient reference. Footnote links are recognized using the EPUB 3 footnote markup as well as some heuristics. Any superscript or subscript links are assumed to be footnote links. Any link that links to another file which in turn links back to the original link, is assumed to be an endnote.
Cover Grid: Improve scroll wheel based scrolling.
|Calibre 2.8.0||Oct 31, 2014||New Release||Linux: Add support for the global menubar in Ubuntu Unity (The menu that is displayed in the top most on screen bar). It now works both with the main calibre program and the e-book editor. You can customize what appears in the menubar via Preferences->Toolbars
Get Books: Add a new store, Bubok (bubok.es)
|Calibre 2.7.0||Oct 24, 2014||New Release||Support for the new Kindle Voyage
The notification for the completion of background jobs, such as bulk metadata download, has been redesigned to not interrupt your work. It now waits in the lower right corner of the main window until you are ready to deal with it
|Calibre 2.3.0||Sep 12, 2014||New Release||New Features:
Cover Grid: Dynamically adjust the size of the in memory cover thumbnail cache based on the window size to ensure flicker free rendering even on very large screens.
Template tester: Remember last used template
Get Books: When downloading books show a popup message telling the user that the books will be added to the calibre library automatically, to help new users understand what is happening. The popup message can be disabled.
E-book viewer: Try to detect when a chapter has a page break before the start of the chapter's text resulting in a leading blank page and override the page break.
Edit metadata dialog: Fix the author sort field not being marked red initially when the author sort does not match the author due to a Qt 5 behavior change.
Fix regression that caused calibre running in debug mode on OS X to not have a menubar or dock icon

domain: library


text:
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"Freaky Tuesday" is the first segment of the twenty-first episode of Brandy & Mr. Whiskers.
After Brandy and Whiskers see a relationship therapist, Whiskers takes an exercise too far and pretends that he's Brandy, and vice versa. Everybody thinks this, except Brandy. In the end, Whiskers is back to his old self.
- The title and plot of this episode are a spoof of the movie Freaky Friday.


In the OxyFuel backhand welding method, the torch precedes the welding rod, as shown in figure 11-5. The torch is held at approximately a 45 degree angle from the vertical away from the direction of welding, with the flame directed at the molten puddle. The welding rod is between the flame and the molten puddle. This position requires less transverse motion than is used in forehand welding.
Increased speeds and better control of the puddle are possible with oxyfuel backhand welding technique when metal 1/8 in. (3.2 mm) and thicker is welded, based on the study of speeds normally achieved with this technique and on greater ease of obtaining fusion at the weld root. Backhand welding may be used with a slightly reducing flame (slight acetylene feather) when desirable to melt a minimum amount of steel in making a joint. The increased carbon content obtained from this flame lowers the melting point of a thin layer of steel and increases welding speed. This technique increases speed of making pipe joints where the wall thickness is 1/4 to 5/16 in. (6.4 to 7.9 mm) and groove angle is less than normal. Backhand welding is sometimes used in surfacing operations.


Cindy Herron-Braggs is best known as a founding member of the R&B/Pop quartet En Vogue from Oakland, California. She began her musical career in the cabaret scene in San Francisco, during the 1980s.
Herron also worked as a background vocalist for local San Francisco Bay Area acts and appeared in the original company of the Jerry Herman musical revue "Showtune" - then titled "Tune the Grand Up."
in 1986, Cindy was named "Miss San Francisco"and placed 2nd-Runner Up in the Miss California Pageant that same year. She is also a former Miss Black California.
In 1988, Herron - a classically trained soprano - was chosen along with Dawn Robinson and Maxine Jones to be in a three-woman girl group by producers Denzil Foster and Thomas McElroy. After adding Terry Ellis to the line-up, the group become a quartet and chose the name En Vogue. Herron and Ellis are the only members of En Vogue to have appeared on every album the group has made.
The group have won more MTV Video Music Awards than any other female group in MTV history, a total of seven, along with four Soul Train Awards, six American Music Awards, and seven Grammy nominations. According to Billboard Magazine they were the 18th most successful act of the 1990s, and one of the most popular and successful female groups of all time.


text:
Background: The diagnosis of different parkinsonian syndromes and the ability to predict long-term drug efficacy constitute important clinical issues.
Design: Motor responses to the acute administration of levodopa and apomorphine were analyzed in a series of 134 parkinsonian patients, including 83 patients with a clinical diagnosis of idiopathic Parkinson's disease (PD), 28 patients with multiple-system atrophy (MSA), 6 with progressive supranuclear palsy, and 17 with an unclassified parkinsonian syndrome.
Methods: The patients received oral levodopa/carbidopa (250/25 mg) and subcutaneous apomorphine (1.5, 3 and 4.5 mg). Clinical variations of the Unified Parkinson's Disease Rating Scale (UPDRS) motor score were evaluated 1 h following levodopa administration or 20 min following apomorphine. The motor improvement produced by each acute challenge was matched with the clinical diagnosis and with the response to chronic levodopa treatment. The diagnosis was verified by repeated clinical assessments or by autopsy in 2 cases. A receiver operating characteristics curve was plotted comparing PD vs. non-PD, PD vs. MSA and chronic responders vs. nonresponders. Cutoff threshold improvement was defined as the value closest to the crossing point for 80% sensitivity and 80% specificity, corresponding to the best trade-off for a predictive evaluation.
Results: UPDRS motor score improvement was on average higher in PD than in non-PD patients (levodopa: 29.8 vs. 12.2%; apomorphine 1.5 mg: 27.1 vs. 10.5%; apomorphine 3 mg: 27.7 vs. 9.7%; apomorphine 4.5 mg: 28.8 vs. 11.8%; p < 0.01 with Student's t test). When PD patients were compared to non-PD patients, levodopa challenge had the best diagnostic accuracy with a threshold improvement of 16%. Apomorphine had the best diagnostic accuracy with a threshold improvement of 13.5% for 1.5 mg, 13% for 3 mg, and 16% for 4.5 mg. This meant that patients improving at least 16% in all tests had the highest probability of having PD. When PD patients were compared to MSA patients, levodopa acute challenge had the best diagnostic accuracy with a threshold improvement of 17%. Apomorphine had the best diagnostic accuracy with an improvement of 13% for 1.5 mg, 15% for 3 mg, and 18% for 4.5 mg. This meant that patients improving at least 18% in all tests had the highest probability of having PD rather than MSA. When patients who responded to chronic levodopa treatment were compared to those who did not, acute challenge with levodopa had the best predictive accuracy with a threshold improvement of 14.5%. Apomorphine had the best predictive accuracy with an improvement of 13% for 1.5 mg, and 14% for 3 and 4.5 mg. This meant that patients improving at least 14.5% in all tests had the highest probability of responding to chronic treatment.
Conclusion: A good agreement was found between acute challenges with levodopa/carbidopa and apomorphine, and the use of both improved the reliability of the test. Different threshold improvements after acute challenges would support a diagnosis of PD or the exclusion of MSA, and would have a predictive value for subsequent response to chronic levodopa therapy.
Copyright 2000 S. Karger AG, Basel.

domain: literature


A lot of Spider-Man movies have been released in the past fifteen years. Andrew Garfield’s incarnation of the web-slinger launched just four years after Tobey Maguire hung up the cobwebbed cowl. Instead of finishing The Amazing Spider-Man series, the iconic character has instead swung into the Marvel Cinematic Universe, with yet another reboot now due for 2017. While it’s easy to see why some fans would be reluctant to get excited about another retelling of the same story so soon, a lot of the criticism already levelled at Spiderman: Homecoming has nothing to do with the potential lack of originality.
Generally, fans have embraced Tom Holland’s Peter Parker. Sadly, there are many people who haven’t been so generous towards his new possible love interest, played by African-American actor Zendaya.
The saddest part is that none of the criticism has much to do with Zendaya’s acting skills or ability to portray the character well. Instead, it all seems to be about one thing: her ethnicity.
Of course, there have been plenty of smart, sensible and even hilarious responses to this sort of hateful language, calling out the racism where people see it.
If Mary Jane isn’t white with red hair the whole story of a dude who gets bit by a magic spider then wears a leotard falls apart
— Todd (@Todd_J) August 19, 2016
But that doesn’t make it any better that a lot of people still subscribe to this backwards, exclusionary attitude.
That’s not to say that there isn’t an argument for casting actors that look as similar to the comic book characters as possible. Comic books are, after all, as much as visual medium as movies are. Characters are often designed to look a certain way for a reason. Writers and artists put a lot of effort into creating a character with specific qualities, designing their physical attributes as intricately as they design their personalities and their histories.
When your favourite comic book characters come to life on the big screen, you want them to be the way you’ve always imagined they will be. It certainly made it easy to fall in love with Robert Downey Jr’s Iron Man because he already looked so much like the Tony Stark in the comics.
But it wasn’t just his looks that won him the role. It was the way he made the character his own without completely changing who Tony Stark was. It was his terrific acting skills, including being able to create excellent chemistry with other actors and improvising in a way that made his performance truly unique. It was his commitment to knowing the character he was playing and doing it in a way that would be relatable to both seasoned comic book nerds and people seeing Iron Man for the first ever time.
If he hadn’t had those skills, he wouldn’t have got the part, no matter what he looked like. A character’s personality is what makes them who they are far more than their physical appearance. Ultimately, having a character portrayed well is the priority when choosing an actor, because the most important thing about a character is very rarely the way they look.
For the most part, fans understand this. In fact, there have been many instances when a comic book character has been completely changed in their transition to the big screen and people haven’t seemed all that bothered.
Looking back over the times when people have kicked up a particularly powerful stink, it is painfully obvious that there is a common theme each time.
There were a ton of people who weren’t happy with Samuel L Jackson being cast as Nick Fury. It was largely the same people who had a problem with Idris Elba playing Heimdall in Thor as well as both Candice Patton and more recently Kiersey Clemmons as Iris West in the Flash television series and movie respectively.
The one thing that all these actors have in common is their ethnicity.
If you need more evidence that this is to do with race, consider the way these same people reacted to John Boyega’s role in Star Wars: The Force Awakens, even though he was playing an entirely original character.
The fact that these actors don’t look enough like their comic book counterparts is simply not a good reason to close off roles to talented people of all ethnicities, people who could take beloved characters into incredible new directions.
Let’s face it, neither comic books nor movies offer an accurate reflection of the diversity of contemporary western society. The straight white male remains the most common protagonist in most media.
Of course, this is at least partially down to the fact that many iconic comic book characters were created before western culture was as diverse as it is today, with many first written in the 1930s. In those days, women, LGBT people, and non-white people were simply not catered to.
Since then, representation has definitely improved, but not at the same rate that society has diversified.
In recreating classic comic book stories, we are given an opportunity to modernise them to fit in better with today’s culture, rather than the one that existed decades ago. Over the years, superheroes have been given more advanced weaponry, updated back stories and even more progressive attitudes.
Why shouldn’t they also have a more ethnically diverse society to live in and protect?
That can’t mean just giving them some different coloured faces in the background. It has to mean allowing primary characters to be representative of all cultures.
Creating that diversity within existing stories requires a lot of careful consideration. Writers and artists can’t dump a new colour on an existing character and expect it to automatically represent a whole group of people. When that has happened in the past, it has come across as a clumsy attempt to reach more of the market without really trying to understand why ethnicity is so important. It doesn’t create an accurate representation of what it’s like to live as a black person, or an Asian person, or a gay person or any other minority group. It’s lazy and it puts off people from all corners of society.
Characters of any ethnicity need to be fully formed human beings with every aspect of their personality and their life story taken into account. Palette swapping an existing character doesn’t do anything to create a more diverse world – and this is where the actors themselves come in.
By opening up characters to actors of every ethnicity, it gives them an opportunity to create a character of their own using the existing story world and putting their own experiences of being a person of colour into their performance. It allows them to rewrite that character in their own way, adding new levels to that character and creating new depth, in more ways than ethnicity alone, in the same way that new writers and actors have been recreating characters in each new incarnation since the 1930s.
This has proven to work time and time again, as actors have silenced the objections of their ‘critics’ simply by providing absolutely stellar performances. Despite getting that initial bad reaction, there is hardly anyone now who doesn’t think that Samuel J Jackson was the perfect choice for Nick Fury. Similarly, Idris Elba’s ability to give a traditionally Norse (the blondest-haired and blueest-eyes of cultures) character such a vividly original yet very relevant personality has been widely applauded.
What many people don’t seem to understand is that this is not a two-way street.
Since Mary Jane is being played by a Black woman, can MLK be played by a White man in a next movie about him?
— Jason Bergkamp (@keksec__org) August 19, 2016
A lot of people justify criticising casting decisions that change the ethnicity of a white character by arguing that it would be unacceptable to cast a white actor in the role of an originally black character like Luke Cage or Black Panther. And they’re right. It would be unacceptable, there is a double standard there.
But there are very good reasons for that.
For a start, white people simply don’t need more representation. Already, the vast, vast majority of people you’ll see on television and in movies and in comic books and in all kinds of media will be white. There is also a statistical likelihood that they’ll be straight, monogamous and male. If you’re going to change a character, it’s not going to make them interesting or original if you give them these very common qualities. People want to know about characters that are unique, who stand out. If anything, this will make them more likely to blend into the background of popular culture.
There’s also the fact that white actors are already taking on a multitude of roles that, in their original form, were not white and they hardly ever get a negative response because of it. Often, there will be a handful of people, usually from within the ethnic community getting whitewashed, who make an effort to be vocal about their opposition to the decision.
But they’re usually ignored and the issue blows over without anyone learning anything from the experience.
Ridley Scott‘s Exodus: Gods and Kings is a prime example of this – a movie set in Egypt, with the English Christian Bale playing the lead role of Moses. When Scott rightly came under fire for this, his answer was heartbreaking for non-white actors struggling to make their way in Hollywood:
“I can’t mount a film of this budget, where I have to rely on tax rebates in Spain, and say that my lead actor is Mohammad so-and-so from such-and-such. I’m just not going to get it financed. So the question doesn’t even come up.”
This failing in the industry makes life even more difficult for people who are already afforded little enough opportunity to perform. If the issue of what a character should look like was really about commitment to realism or loyalty to a pre-existing story, then the people protesting Zendaya and Idris Elba would have just as much of a problem with this kind of ethnicity change, too.
But they don’t. For the most part, people happily watch the movies where a white actor plays an Asian or a Middle Eastern or even an African person and often don’t question it. They still see the films in the cinema and they still buy the DVDs and the studios that make the decision to neglect actors of colour profit comfortably. As long as they are still making that money, they have no motivation to change their practice.
And this is not an isolated incident.
Even though non-white actors are in a much better position today than they have been in the past, characters of colour are still being given to white actors on a regular basis. American actor Jake Gyllenhaal was cast as the lead in Prince of Persia, set in the part of world now known as Iran. American actor Scarlett Johansson was cast as the Japanese Major Motoko Kusanagi.
In a move that was probably trying very hard to be progressive, a gender-swapped Ancient One in the Doctor Strange movie due out later this year lost the iconic Tibetan heritage to British actor Tilda Swinton.
While these decisions have been questioned in some circles, they haven’t had anywhere near the kind of vitriol levelled at them as those that changed ethnicity in the other direction.
But the main reason the choice to change a character’s ethnicity doesn’t currently work on a equal basis is that white characters are rarely as defined by their ethnicity as characters of colour are.
Black Panther, for instance, has an incredibly intense relationship with his ethnicity that is unheard of among white characters. His African heritage is integral to his character and to change that would change who he is entirely. His backstory specifies that he is a tribal chief from a fictional African nation called Wakanda. He existed within a very specific place and the experiences he had there define the hero he became.
Changing his ethnicity changes him entirely. A white man would not be born into an African tribe, certainly not into the royal bloodline of an African nation. To remove T’Challa from Africa to justify changing his ethnicity would remove everything about his past that defines him, both as a character and as a hero.
White characters often don’t have relationships like that with their cultures.
When a character does have a close relationship with, for instance, the western city they grew up in, that doesn’t mean that they have to be white. Modern metropolises like the ones protected by Batman and Superman and The Flash and Daredevil and basically all of the city-based superheroes are very diverse in terms of population. A person of any ethnicity could feel that same connection to their hometown.
But it certainly wouldn’t make sense for a non-African character to have such an intense connection to an African nation or tribe.
On top of that, there is the impact that Black Panther had on representation of people of colour within society.
As the first mainstream African-American superhero, he is the figurehead of black representation in comic books. He was a catalyst in creating a more diverse comic universe and a more diverse media in general.
The timing of his release had a huge impact because of the racial tension, particularly in America, at the time. The first Black Panther comic book was published in 1966, just a year after the assassination of Malcolm X. 1966 was the same year that Martin Luther King gave his first speech about the Vietnam War. Race riots took place in both Michigan and Cleveland, and Constance Baker Motley became the first African-American woman to become a Federal judge. 1966 was a crucial year for African-Americans and having a black character presented as a positive role model contributed to that.
Black Panther’s significance as a non-white character was so important when his stories were first published that to reverse it now would be a slap in the face to the social progress it aided. Black Panther’s cultural identity – both within the comic world and the real one – is so crucial that to change it would completely undermine everything the character has stood for in his fifty years in print.
There is no white character that has that same level of cultural significance specifically because of their ethnicity.
Ideally, we would create diversity in popular culture by writing new characters who break the mould in every respect and give them the same kind of media attention that existing straight white male characters have enjoyed for decades. Unfortunately, new characters – of any description – don’t sell as well as those who exist in established worlds who already have huge fan bases.
Until this changes, people are creating a more diverse representation of the world by being more inclusive in the way they rewrite existing characters. That means allowing writers to explore what a character would be like if they were a different gender or sexuality or ethnicity.
Characters are updated and changed every time a new writer creates a new story for an existing character, every time a new actor is cast to play one, even if the changes are only subtle. Putting restrictions on how they choose to do that stunts the way culture evolves.
Society right now has a unique opportunity to create a wealth of new literature based on cultures from all over the world, to blend together tales from vastly different backgrounds to create entirely new stories. Working in ethnically diverse groups is the key to achieving that and those opposing it are going to get left behind as the rest of the world progresses.
The people working in those groups know this. The creators know it and they have unanimous support from the creative community around them. Stan Lee himself took the time to defend the choice to cast Zendaya in Spiderman: Homecoming. And recently Guardians of The Galaxy director James Gunn directed said this in defense of Zendaya as Mary Jane:
For me, if a character’s primary attribute – the thing that makes them iconic – is the color of their skin, or their hair color, frankly, that character is shallow and sucks. For me, what makes MJ MJ is her alpha female playfulness, and if the actress captures that, then she’ll work. And, for the record, I think Zendaya even matches what I think of as MJ’s primary physical characteristics – she’s a tall, thin model – much more so than actresses have in the past.
Whatever the case, if we’re going to continue to make movies based on the almost all white heroes and supporting characters from the comics of the last century, we’re going to have to get used to them being more reflective of our diverse present world. Perhaps we can be open to the idea that, although someone may not initially match how we personally conceive a character, we can be – and often are – happily surprised.
People wouldn’t be making these casting and writing decisions if they didn’t know it was the best choice. It’s nothing but insulting that they then have to publicly justify their decisions to people who call themselves fans.
The only people who have a problem with it are the people who have nothing to do with the creative process – they are a small, but annoyingly loud, proportion of the consumer base. Perhaps its time they started accepting the decisions of the professionals.
With Roxane Gay writing the new Black Panther comics and Zendaya romancing Spider-Man, Marvel is embracing the many shapes, sizes and colours of the global community and celebrating it the way it deserves.


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Research on a Control Unit of in-Wheel Motor Applied in Mobile Robot
Compared with the driving system of traditional motors, the advantages of in-wheel motor are described in this article. A kind of drive control unit of in-wheel motor is designed for mobile robot, and its composition, working principle, hardware and software design are described. Experiments show that the control unit can make a good performance to meet the requirements of mobile robot.
Q. Yin et al., "Research on a Control Unit of in-Wheel Motor Applied in Mobile Robot", Applied Mechanics and Materials, Vols. 52-54, pp. 133-138, 2011

domain: design


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Page 2 of 2 Previous
SAFE Elders initiative
In June, Palumbo helped launch a statewide initiative to confront elder abuse with an arsenal of resources to educate people about the problem.
With nearly $50,000 in donations, the organization Minnesota SAFE Elders created a tool kit that includes such things as a video and free training materials, an app for first responders, and a “prosecutor’s trial notebook,” a collection of abuse cases that attorneys can use as a reference when developing their own cases.
While the Kulbeik case wasn’t a result of the SAFE Elders initiative, it highlights the issues the group is trying to address in the community, said Palumbo.
“The injuries to the victim were extremely severe,” he said. “We are obviously holding the defendant accountable for her failure to provide aid.”
David Chanen • 612-673-4465
Poll: Do you agree with baseball's plan to ban collisions at home plate?

domain: law


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Questions regarding clair®
Here, you can find answers to frequently asked questions regarding the topic of clair® air tonic. If you have a specific question, please contact our support team or feel free to write us a message using our contact form.
Q&A - clair® air tonic
clair® air tonic is a one-of-a-kind thyme product for dispersion in room air using ultrasonic cold nebulisation. The innovative formula ensures optimal distribution and effectiveness of the ingredients in the air. The room climate is improved with lasting effect.
clair® air tonic contains the following ingredients: Thyme extract, fruit and vegetable concentrates, triglycerides, ascorbic acid, glycerin, polysorbates, water.
clair® air tonic is dispersed in indoor air using ultrasonic technology. The gentle nebulisation process produces finely dispersed droplets that evenly distribute throughout the room, releasing thyme's active ingredients into the air for an extended period of time thanks to our special formula.
The full power of thyme – in every breath.
clair® air tonic - Thyme at its best.
In most cases, essential oils are used in aroma lamps. When heated, the volatile ingredients of the oils quickly vaporise and become noticeable to the senses. However, these molecules change when they come into contact with the oxygen in the air rapidly losing their function and effect. Other ingredients in the oils remain in the aroma lamp and are not released into the air at all.
While using an ultrasonic diffuser with water and essential oils captures all the ingredients from the oils in the droplets, the efficacy also diminishes rapidly in this case due to oxidation.
With clair® air tonic, all ingredients in thyme are protected thanks to its unique formula. Only upon contact with the droplets are they released and able to exert their effect.
clair® air tonic captures the essence of thyme. Lightly spiced notes combine with more sweeter nuances to create a harmonious presence in the room. A fragrance that only nature can create.
Thyme is a special plant with exceptional properties; it has been used for countless generations in Europe. These effects have now also been investigated and proven on the basis of scientific standards.
Depending on how often you use it, a bottle of clair® air tonic will last for ca. 80 - 100 hours.
Our diffuser is intended for use in rooms of up to 30m² in size. Multiple diffusers can be combined for larger rooms.
clair® air tonic has a shelf life of at least 1 year. Once opened, the bottle contents should be used up within 3 months.
All ingredients in clair® air tonic are naturally occurring and have undergone strict quality controls. If used properly, clair® air tonic poses to risk to children or pets. However, given that it is not intended to be consumed, it should be stored out of the reach of children.
Our clair® air tonic is manufactured and bottled in Germany.
No. clair® air tonic is only designed for use with the enclosed diffuser.
Q&A clair® - Shop
Our products are ready to ship within 1-2 days of order placement.
Delivery time 5-10 working days.
We guarantee a secure shipment in cooperation with our shipping partners.
At our Clair Organics Shop, you can pay using the following services:
- Apple Pay
- Google Pay
- Master Card
- Shop Pay
With us, you have a 30 day right to withdraw from the purchase agreement and return the product.
For more information, please click here.
Please click here for the Legal disclosure.
Q&A ultrasonic diffuser
In the living room, bedroom, bathroom, wherever you want. As it is
battery operated, you can set it up in any room you are
in. Placing it in a central location in the room ensures optimal dispersion.
The diffuser holds max. 50ml of clair® air tonic, indicated by a marking on the liquid container. Please note that the maximum filling level may not be exceeded as the device will no longer function properly and, under certain circumstances, this may result in damage to the diffuser (also see the operating instructions).
Yes! The charge of the ultrasonic diffuser’s battery lasts 7h. Before using it for the first time, however, it should be charged once for 6h. If the diffuser is empty, a LED on the back will blink. Then it has to be recharged.
When plugged in, it can be operated for up to 10 hours and, when battery powered, for up to 7 hours.
Our clair® air tonic is manufactured using deionised water, so all you have to do is rinse out the diffuser tank with clean water and, if necessary, wipe it out with a damp cloth. In the process, make sure that no water enters the vents. Then let it dry and the ultrasonic diffuser is ready for operation. Now all you have to do is refill it with our clair® air tonic and turn it on.
First make sure that the LED dimmer is activated. A button is located on the front side above the ON/OFF button, it can be set to normal, dimmed and deactivated. Push it until the flame is at full strength.
- Disconnect the charging cable and switch the diffuser off.
- Empty the water tank and rinse it out with lukewarm water.
- Connect the charging cable to the diffuser again.
- Hold the LED button & ON/OFF button for 2-3 seconds.
- The LED should now blink four times.
- Fill the water tank and switch the diffuser back on
Generally speaking, clair® air tonic can be used with other ultrasonic diffusers as long as their membrane is not supplied via a wick system. If the membrane of your diffuser is located under the liquid to be filled, it can also be used for clair® air tonic.
The ultrasonic diffuser in our clair® Welcome Set is designed for the most common room sizes of up to ca. 30m². Using a different diffuser may, in some cases, significantly increase the amount of clair® air tonic dispersed, causing an overly intense fragrance experience, although this is completely harmless. We recommend dispersing approximately 0.1ml/m³/h.

domain: chemistry


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Keep Pets Safe During Windy Weather!
El Paso winds are still around. Wind gusts and flying objects can injure or frighten your pets. Dogs and cats may run away or get disoriented when fences blow down, objects fall or fly in the wind or the noise of a big gust may frighten them.
- Bring your pet inside during the storm or make sure they have sturdy/secure shelter.
- Provide a dry, elevated dog house with clean dry bedding and a flap over the opening to keep drafts out. A doghouse should allow your puppy-dog to comfortably sit and lay down but small enough to hold in its body heat.
- Check ALL fencing and LOCK all gates
- Keep a KISS eye out on el paso craigslist-lost and found, el paso animal services, humane society of el paso, lost and found pets in el paso, and you can take to most Veterinarians for a free check, to see if they are microchipped!

domain: pet


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The star of one of CW's best shows hits the young adult section of the book store in this all new series! While I've never actually been a fan of the comic book character, The Flash, I really do love the television show. The stories are well-written (albeit a bit long with these season-long storylines), and the acting is superb. They have an amazing cast, who seem to really gel and have natural camaraderie. So, I bought this first young adult novel with the anticipation that it would be just as fun as the show.
And, for the most part, it was!
The Flash: Hocus Pocus tells the story of what might have happened had Iris prevented Barry Allen from going into the past to save his mother. The timeline did not change due to Flashpoint, and Barry and all of his friends maintain their status quo. Life seems idealistic, and everything is running smoothly ... until Caitlin and Cisco happen across a street magician who appears to have the ability to make his audience do what he wants - adore him! This man who calls himself 'Hocus Pocus' is able to control his audience, making them applaud and praise him for even the simplest of tricks. Lucky for the citizens of Central City, that control is only temporary and eventually fades.
Author Barry Lyga takes readers on a fun little "what if?" story, showing what Flash would have been like if he had not gone back in the past and tried to save his mother. Of course, that doesn't mean he won't face a maniacal villain. And it certainly doesn't mean he won't make mistakes that will get him, and possibly his friends, in trouble. But, it does mean that Caitlin is not Killer Frost ... yet. It does mean that Cisco's brother is not necessarily dead ... yet. And it does mean that Barry Allen may have an entirely different set of problems to deal with at work - such as Captain Singh deciding he has had enough of Barry's numerous absences, unexplained tardiness, and, even though he always gets his work in and does an excellent job, his multitude of excuses. You see, in this book, Barry is put on leave until the department decides whether they are going to keep him on with a warning or terminate his position.
And just when Hocus Pocus has come to town and begun controlling people, making them do exactly what he wants. Is he a meta? Or is he simply so technologically advanced, he has a device (say, a wand) that allows him to reach into the minds of those around him and cause them to bend to his will? Or, and this is the one that Barry and his crew have a hard time swallowing - is it truly magic?
Once Hocus Pocus gets a hold of the Flash, he doesn't intend to let go! Suddenly, the Flash finds himself at the beck and call of this attention-starved madman! He cannot touch him, he can't defeat him, and when he is forced to rob a jewelry store in front of hundreds of Central City citizens, he finds himself the target of the Central City Police! Cisco and Caitlin cannot figure out how he is doing this, and H.R. seems only concerned with the Flash's marketing. How are they going to stop Hocus Pocus, restore the Flash's reputation, and get Barry his job back?
And what is it with these odd bodies that are turning up dead with missing organs? Does it have anything to do with something that is living down in the sewer?
A definitely episode-worthy story of The Flash, and a book well worth the read for any fans of the television show!
RATING: 9 inverse transmitting neuralgic transformers out of 10 for a well-crafted tale and for bringing Madame Xanadu into the CW television universe!


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I measure the march toward spring by the arrival of the first dandelion in my ‘flowery mead’ which some call The Lawn. Yesterday, the first dandelion showed up, at least a week earlier than usual. This morning it has been joined by a host of sunny compatriots. I hope the five days of 80 plus temperatures haven’t lulled us into a fatal spring.
Along with the dandelions, these violets seemed to pop up and bloom over night in the sand next to the house where we are planning to put more pavers. And witch grass. Of course. Who could call such beauty a weed? There are more violets, white and purple in the flowery mead. They indicate that my soil is acid. I knew that.
This Post Has 4 Comments
I know they are a weed, but dandelions have such beautiful yellow flowers along the roadsides (and your lawn). And they have such fun seed heads for little ones to blow and scatter for future generations. – Margy
Margy – Dandelions are precisely the common weeder that my blog is named after. I’m quite fond of dandelions.
Now. If I could just remember to get out there and grab those dandelion leaves before the blossoms appear, we could Eat them! 🙂
Shady – My grandfather had us pick dandelion greens for his salad but they were a little bitter for me. Recently I saw a bunch of giant cultivated dandelion greens in the supermarket. I almost didn’t recognize them


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Gold is one of the rarest elements in the world, making up roughly 0.003 parts per million of the earth’s crust. But how much gold is the world digging up each year and what countries produce the most?
In 2018, global gold mine production was a reported 3,332 tonnes. This figure is up 2 percent from the previous year and is the largest year-over-year growth in the last four years, according to the GFMS Gold Survey 2019. The driving forces behind increase in production came out of operations in Argentina, the U.S., Russia and Mali.
Although production was up in 2018, versus a small decrease of 5 tonnes in 2017, it raises the question I’ve explored recently – have we reached peak gold? The idea is that all the easy gold has already been discovered and explorers have to dig deeper to find economically viable deposits.
For example, South Africa was once the top gold-producing country by far, digging up over 1,000 tonnes in 1970, but annual output has fallen steadily since. On the other hand, several nations have emerged in the last few years as growing gold producers.
As seen in the chart below, China takes the number one spot of global gold producers by a wide margin, extracting 87 tonnes more than second place Australia. The top 10 rankings remained unchanged from 2017 to 2018, with the exception of Indonesia and Peru switching between sixth and seventh place, respectively. Of the top producers, Indonesia posted the largest annual gain, boosting output by 23 percent.
For the rest of this article: https://www.kitco.com/commentaries/2019-06-26/Top-10-Gold-Producing-Countries.html

domain: geography


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The death penalty is one of those areas that I have had a change of views on over the years. At one time it did act as a deterent to some crimes. This isn't so much the case any more. For this to be an effective anti-crime measure constitutes a society where respect for others, their property, rights and freedoms must be the driving factor in life. Sad to say, but this is not so common in the American culture anymore. Other things to consider is the fact our legal system has gone way of course and has many flaws which must be addressed. We have jailed too many people falsely for one reason or another and years later find out the truth only to turn them loose. The appeals process is also very long, drawn out and expensive on our people. Yet in the current shape of our legal system it is almost required. Executing people in this type environment is iffy at best. Do I believe that there are those who should suffer this punishment? YES. We have had those who were so horrid in their actions that it would be doing society a favor by doing away with them and not costing the tax payers to keep them locked away forever. Yet there are few in recent history to fall under this category. At some point in the future when we regain a respectful society and clean up our legal system maybe then and only then would the death penalty be an option. Even then it is questionable.
I have sense enough to realize that times change and what worked at one time is no longer of any use or that things that did not work at one time may work now. In my view the Death Penalty is one of these that is no longer a sensible alternative. Thus we need to move to Life Without Parole as the current method of punishment.


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A quick recap: Markets are continuing to heal from the acute weakness of August and nervousness of September. Stocks are rallying, the Aussie dollar is back above 72 cents, commodities are higher and emerging markets are recovering.
Ray Attrill, the NAB’s co-head of global currency strategy summarise the moves in emerging and forex markets this morning saying, “The rapid reversal in post-August 11 Emerging Market and commodity currency weakness continued with a vengeance overnight. The Malaysian Ringgit is 3.6% up on this time yesterday and the Indonesian Rupiah 3% higher. At 0.7211, AUD/USD is now 4.1% above its recent (Sep 24) lows, and NZD at 0.6612 some 6% higher over the same period.”
He says that a large part of the reversal is “predicated on a view that China will now maintain a relatively stable CNY through the rest of this year at least and following strong verbal commitments by President Xi during his recent U.S. visit. And, we’d also note, ahead of a likely IMF decision on China SDR inclusion (likely next month).”
The recovery in sentiment is consistent with what we usually see in markets. We had the crash in August, we had multiple tests toward the lows in September which held and now traders are looking for topside resistance.
It looks like they found some in oil last night which reversed off the range top. Likewise stocks in Europe tanked in the last hour of trade overnight. Certainly the UK, German and French indexes ended in the black but it could have been a much stronger day. Some of that weakness was probably associated with the US mid-morning swoon which reversed with stocks climbing steadily from their lows around 11am to close with gains of a little under 1%.
That all adds up to what looks like another good days trade on the ASX today. The December SPI 200 futures contract rose 32 points last night to 5,221 after the 0.6% rally on the physical yesterday. BHP and Rio both did well again in London trade and even though crude reversed a little from its highs the energy complex is still strong relative to the lows and a week ago.
Elsewhere on commodity markets base metal prices were stronger with lead up 3.1%, zinc 2.2% higher and copper up 0.64%. Iron ore was up a little as well.
In data news the US housing sector is powering along it seems. Craig James, CommSec chief economist, reports this morning that the “CoreLogic HPI home prices increased by 6.9% in August compared with 12 months ago. The US MBA mortgage applications index lifted to 534.2 – the highest level in 8 months.” But consumer credit growth undershot expectations with a print of $16 billion against the 19 billion expected.
On the data front in Australia there are no major economic data to be released. In Japan we get a raft of second tier economic data including foreign investment, BoJ survey, and machinery orders. German trade is out tonight along with a Bank of England rates decision. In the US, we get minutes from the last Fed meeting.
China is back today, Shanghai should have a good rally.
The overnight scoreboard (7.46am AEST):
- Dow Jones Industrials +0.73% to 16,912
- Nasdaq Composite +0.9% to 4,791
- S&P 500 +0.8% to 1,995
- London (FTSE 100) +0.16% to 6,336
- Frankfurt (DAX) +0.68% to 9,970
- Tokyo (Nikkei) +0.75% to 18,322
- Shanghai (composite) Closed – last at 3,053
- Hong Kong (Hang Seng) +3.13% to 22,515
- ASX Futures overnight (SPI December) +32 to 5,221
- AUDUSD: 0.7206
- EURUSD: 1.1236
- USDJPY: 119.97
- GBPUSD: 1.5316
- USDCAD: 1.3024
- Nymex Crude (front contract): $48.07
- Copper (US front contract): $2.3695
- Gold: $1,145
- Dalian Iron Ore (January): 366.5(denominated in CNY)
- US 10 year bond rate: 2.07%
- Australian 10 year bond rate: 2.67%
In other news.
– This one from the FT caught my eye this morning. The author argues that the “defensive strategy can be a risky one.”
With the International Monetary Fund warning on Tuesday that global growth will be the slowest since the financial crisis, markets are pricing in a relatively bleak outlook with worries centred firmly on the Chinese economy and the potential effects of a rise in US interest rates on emerging markets.
Indeed, the S&P 500 is still trading below its 50-day, 100-day and 200-day moving average and about 7 per cent below its peak before the summer sell-off in August. Defensive US stocks have also outperformed the wider indices, while cyclicals have sharply underperformed.
A sustained improvement in sentiment, though, could leave defensive fund managers vulnerable as overcrowded trades can unwind quickly, leaving investors who have put their faith in so-called safe stocks nursing heavy losses and bruised egos.
Yep, it could. The key here of course, as you’ll read in Business Insider and elsewhere, stock investing is for the long run and the points made are good ones. But, from a trading point of view the article points to the balance of risks with lots of bad news priced into the markets.
All we need is a not bad earnings season in the US and we could be off to the races with the S&P and other indexes leaping higher.
– Speaking of earnings season, the FT’s excellent John Authers reckons we might all need to hold tight because the strong dollar and lack of guidance could make it a bumpy ride.
– The rally on oil markets came to an abrupt halt overnight. News that US stockpiles have grown more than expected saw previously ebullient oil traders hit the sell button. Of course the price of the front Nymex crude contract is still above $48 a barrel this morning – so it’s not exactly weak – but as you can see in the chart below from a trading perspective it’s a “failed break” of the current trading range.
And now from CMC Markets’ Michael McCarthy for today’s Stock of the Day
Precious – Platinum Asset Management
Platinum Asset Management (PTM) is a former market darling. The hot ardour that drove PTM to its all time high earlier this year cooled significantly following the 2014 H2 results, reported in February this year. A share price now below $7 may see investors re-kindling the love affair.
The last half of 2014 blotted PTM’s almost spotless record, showing a 23% fall in performance fees and a flat profit. This nasty surprise wrought significant changes in analysts’ estimate of future earnings, and saw valuations smashed. While investors and analysts have a passion for smoothly rising earnings, the messy reality of life is that markets and profits regularly depart from these straight lines.
Investors backing PTM as an alpha generator may therefore see the current pullback as an opportunity. The share price is sitting well below the long run averages, reflecting the downtrend this year. However, yesterday’s plunge saw PTM pull back to its shorter moving averages, potentially putting it in the buy zone.
Michael McCarthy, chief market strategist, CMC Markets
You can follow Michael on Twitter @MMcCarthy_CMC
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domain: finance


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The local election cycle will kick into high gear this coming Monday, when city candidates take to the mic during a Candidate Forum.
Mayor Elizabeth Kautz will face two-time challenger Jerry Willenburg, who gave Kautz the toughest race of her long career in 2008, according to Sun ThisWeek. Vying for two council seats will be former Council Member Steve Cherney, Bruce Johnson, Suzanne Nguyen and incumbent Mary Sherry.
This candidate forum is presented by the Burnsville Chamber of Commerce. If you wish to see the forum, it will be streamed live online at www.burnsville.org/meetings and on Burnsville Community Television (BCTV) Channel 16. Check www.burnsville.tv for replay times.
You can also watch the forum in person at City Hall, 100 Civic Center Parkway, in the Council Chambers. The event runs from 5:30 p.m. to 7:30 p.m.


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With Thanksgiving only a few weeks away the challenging task of matching a wine to the traditional feast should be by now well under way.
Thanksgiving challenging? Not just because it’s a big chore to put on and one must deal with numerous friends and relatives vying for an enviable seat at your table, but because the traditional meal does not lend itself easily to one particular Thanksgiving wine. You need a Thanksgiving wine guide.
Here is the challenge. You’re having turkey (with both white and dark meat) or maybe a ham, along with a savory stuffing, spicy potatoes, rich dark gravy and a tangy cranberry sauce. Maybe you rub your turkey with Creole butter, or rosemary sprigs or prepare it with an orange glaze, or deep fried with brown sugar. The point being there are many ways to prepare the traditional bird, and the meal itself can have a diverse mix of sweet, sour, salty, savory and spicy components. A perfect Thanksgiving wine needs to handle the diverse flavors and not overwhelm the focal point of the meal.
So what to do? Here are some recommendations to attempt to cover all the bases. If you tend to cook with more seasoning and spices the red Thanksgiving wines might work the best. We do suggest that you offer both a white and red options for your guests.
White Thanksgiving Wine Varieties
Pinot Gris – A light refreshing wine with pear, lemon and tropical fruit flavors. It can be overwhelmed if your food is overly seasoned.
Dry Riesling or Dry Gewürztraminer – the right balance of a slight sweetness and aromatic, spicy and floral fruit makes a lovely compliment to roasted turkey.
Chenin Blanc – Semi dry wine with floral, grass and honeysuckle aromas. Sometimes has a pleasant mineral or herbal quality that can add complexity.
Chardonnay or Pinot Blanc – Flavorful with flinty and fruity aromas made medium body and dry. These wines can stand up to well seasoned poultry. Finding one with little or no oak may work best with turkey.
Red Thanksgiving Wine Varieties
Gamay Beaujolais – (or Beaujolais Nouveau) These wines are often made in a white wine style where the juice has little contact to the grape skins. These light wines are served cooled and exhibit fruity, sometimes strawberry flavors.
Pinot Noir – The earthy, cherry, olive and raspberry flavors of this grape tend to match well with seasoned poultry and meats. Good with savory stuffing.
Merlot – A medium bodied Merlot with its peppercorn, green olive and earth and coffee flavors can often match well seasoned poultry and even ham. (Some might consider it a more risky choice.)
Zinfandel – Medium bodied Zin will stand up to spicier dishes. The ripe plum and blackberry fruit flavors along with a peppery finish works well with those more exotic poultry preparations. Also pairs well with ham.


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I started this book with no preconceived notions as I had never heard of this book or watched the movie before picking it up from the library shelf. So it was just a casual read. From the cover and the name, I expected a clichéd, cheesy romance story. However I am glad to announce that I was proved wrong. This book, in no way portrays a romance between the two main characters. So along with a book review, you also get a lesson of “Don’t judge a book by it’s cover”.
Vianne Rocher and her daughter Anouk (and Anouk’s imaginary pet rabbit) are wanderers who have spent their lives travelling place to place, never staying at one place for too long. On Mardi Gras, they stumble upon a quaint little French town, Lansquenet-sous-Tannes attracted by the beautiful festivities. They rather enjoy themselves at the festival and decide to stay. Vianne rents a bakery and transforms it into a charming chocolate shop, something unheard of in the town. These two turn heads and invite curiosity and hostility from the nosey townspeople. Vianne sparks the wrath of the village priest, Father Reynaud, who thinks that opening such a shop right in front of his church, in the month of Lent, a time of fasting, is an insult, and a menace, to religion. He also doesn’t approve of Vianne because of her refusal to attend church or confession, and convinces some of his parishioners to stay away from the “evil” chocolate shop.
He believes Vianne is some kind of a witch or sorcerer who was a threat to the Church and the people’s faith. Whether Vianne does have any supernatural powers or could perform magic, is never clarified, she denies any mention of it.
“I sell dreams, small comforts, sweet harmless temptations to bring down a multitude of saints crashing among the hazels and nougatines”
A little bit of magic, good people, bad people, gypsies, little songs in French, an imaginary friend, love, loss, mystery and more chocolate drink than I could have imagined; this is a fascinating book.
The descriptions will make you yearn for chocolates and hot chocolate drinks. That’s a guarantee because I don’t even love chocolates that much, but still I had unbearable cravings.
The story alternates between the first person narratives of Vianne and Père Reynaud. Most chapters tell Vianne’s story, but some are told through the eyes of Reynaud, as he speaks of his fear, desires and crimes to someone only referred to as “mon père”. This allows the readers to understand the two characters and their complex personalities and opposing opinions more intimately.
An aspect I really loved about this book was that the minor characters and the sub-plots were as 3-dimensional as the major ones. The sub-plots were beautifully interwoven with the main plot and were relevant to the development to the story. Each and every character was well rounded and memorable.
The ending of the book is not conclusive and left open to interpretation. You are left wondering what Vianne and Anouk’s decision would be – another adventure or stability at Lansquenet?
“Places do not lose their identity, however far one travels. It is the heart that begins to erode over time. The face in the hotel mirror seems blurred some mornings, as if by too many casual looks. By ten the sheets will be laundered, the carpet swept. The names on the hotel registers change as we pass. We leave no trace as we pass on. Ghostlike, we cast no shadow.”


Service bulletin inventory management and modeling for aerospace parts in customer service organization
Author(s)Pardede, Erna K. (Erna Kertasasmita)
Leaders for Global Operations Program.
Donald B. Rosenfield and Olivier L. de Weck.
MetadataShow full item record
The Customer Service department of United Technology Corporation (UTC) Aerospace System is primarily responsible for providing spare parts, repair services, training, and technical support for products that UTC Aerospace Systems develops. The goal for spares turn-around time is a 7-day or less and for repair turn-around time is a 15 -day or less. In reality, most of parts needed to support spare parts' order and repair operations have lead times that are greater than the targeted turn-around time, which leads to a costly build-to-stock inventory policy. Proper inventory management becomes the focus of the department, given that both inadequate and excess inventory can have a financial impact and damage the overall health of the business. This thesis presents a project to develop a method and implement improvements to the current inventory management. Service Bulletins (SBs) are recommended procedures for repairing products. A SB is issued by UTC Aerospace Systems Customer Service to their customers when there is a safety concern to the current product, or when improvement to the original product design results in either increased performance or lower maintenance costs. Management of a Service Bulletin begins with an engineered solution to an existing product, followed by a ramp up in inventory to support the retrofit activities. Management of the inventory to support these Service Bulletins can be complex and very difficult as it depends on estimates of units in service and timing of units to be returned to UTC Aerospace Systems Repair, and part replacement rate estimates of certain components. Actual units returned, the timing of the returns, and the actual part replacement may vary from earlier estimates made by UTC Aerospace Systems technical personnel during the preparation stages, and therefore require good inventory planning. The author began the project by conducting interviews with key personnel., assessing the current state of service bulletin process, and documenting challenges faced with the current process. An initial hypothesis of the units returned model was made based on the nature of service bulletins (Safety, Retrofit, and Attrition). Data extraction and analysis of existing service bulletin units returned was conducted, focusing on the descriptive texts that were provided by repair personnel. Detailed reviews with subject matter experts were conducted to confirm the observations and analysis. Finally, a consensus was reached on the type of service bulletin that the author should focus on assessing. Mechanistic growth models of units returned were developed and proposed. The models could be used to determine order points based on average return rates and variance. Utilizing the models to build process monitoring tool in turn could support inventory reduction by at least 30% while reducing the amount of work order shortages.
Thesis (M.B.A.)--Massachusetts Institute of Technology, Sloan School of Management; and, (S.M.)--Massachusetts Institute of Technology, Engineering Systems Division; in conjunction with the Leaders for Global Operations Program at MIT, 2013.Cataloged from PDF version of thesis.Includes bibliographical references (p. 73-74).
DepartmentLeaders for Global Operations Program at MIT; Massachusetts Institute of Technology. Engineering Systems Division; Sloan School of Management
Massachusetts Institute of Technology
Sloan School of Management., Engineering Systems Division., Leaders for Global Operations Program.


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Actually there is a best-selling thriller novel that has the title “Absolute Power.” Written by David Baldacci, this novel has all the power elements of a suspenseful thriller. First of all, it is a story of a fictional POTUS who is living life a tad indecently. And he has a bad habit of abusing women. Domestic abuse is a very real problem. It was very ingenious of the author to approach the topic in a way to shine the light on the idea that men who abuse women are usually men who crave power. And what is more powerful than being the president of the United States? “Absolute Power” is an example of a thriller novel with a powerful punch.
“A Moving Screen” is a thriller novel with a serial killer who has absolute power. No one knows who he is. No one knows when or where he will strike next. No one can identify his victims. Not even the police! He kills at will and at his pleasure. When it comes to committing the perfect murder, this killer has absolute power. “A Moving
Screen” is also a thriller novel with a powerful punch.
The best thriller novels approach real life issues in a creative way in order to shine light on serious issues while at the same time entertaining. This approach, when done well,
carries absolute power.


Web portal Yahoo!'s new search partnership with Microsoft poses an array of new challenges for Yahoo! CEO Carol Bartz, including shifting sales resources to work on Microsoft products, dealing with regulatory scrutiny and further downsizing the company. Bartz said: "Our strategy as a company is growing audience and enhancing our display-ad leadership. That is what really makes sense."
Published in Brief:


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Join Lynell Harlow, Founder of Dreamweaver Stencils to learn how to stencil color on your embossed designs.
A fast and fabulous technique for making really different images using Dreamweaver Metal Stencils and erasers.
Learn how to make a perfect Cloud background for any project using the Picasso Stencil Shield by Dreamweaver.
Enjoy the beauty of embossed metal using your Dreamweaver Metal Stencils and your die cutting machine.
Lynell shows how easy it is to make perfect plaids with embossing paste and the plaid stencil.
Watch Lynell Harlow create beautiful, ink transfer cards with Dreamweaver Metal Stencils and Memories Mists.
Let Lynell Harlow of Dreamweaver Stencils show you the quickest, easiest way to emboss and color metal stencils.
Lynell Harlow shows the use of mica powders with matte pastes and Dreamweaver Stencils. Dramatic, dynamic, WOW!
Join Lynell Harlow as she teaches the beautiful (and sparkly) Dreamweaver Stencils Double Glitter Technique!
Follow along with Lynell as she demonstrates one of the most popular Dreamweaver Stencils techniques - Mica Powders on Black Paste.
Let Lynell Harlow show you how to safely remove your Dreamweaver Stencils from the package without bending.
Stampendous is thrilled to be adding Dreamweaver Stencils to our family of products. These premium metal stencils and top of the line accessories are the perfect enhancements for your stamped art or any surfaces. Please enjoy learning about how to use these fantastic tools from their designer and Dreamweaver Stencils' Founder Lynell Harlow.


As federal officers prolong an unwanted incursion into Portland to quash street protests, acting Secretary of Homeland Security Chad Wolf received a cold shoulder from local leaders.
Mayor Ted Wheeler was joined by nearly every major figure in Oregon government in rebuffing Wolf, who arrived for a photo opportunity where he toured graffiti scrawled on the Mark O. Hatfield federal courthouse and decried the "violent anarchists" who defaced it. His visit was part of a crackdown orchestrated by President Donald Trump in an election year to quell protests—an experiment that has included arrests made via rental car and a protester shot in the face with a munition.
Among the few people who did chat with Wolf? Portland police officers.
A photo posted by Wolf on social media this morning shows him meeting with an officer wearing a Portland Police Bureau insignia on his arm. It appears to be an informal meeting inside the federal courthouse. "These valiant men and women have defended our institutions of justice against violent anarchists for 48 straight days," Wolf captioned it. "We will prevail."
At a press conference this afternoon, reporters asked whether Portland police officers had met with Wolf. Police Chief Chuck Lovell said he didn't know.
Shortly after the press conference ended, the Police Bureau issued a statement amending Lovell's remarks—and saying Officer Daryl Turner, head of the Portland Police Association, had met with Wolf. Turner's police union has repeatedly been the target of protesters who march to its headquarters on North Lombard Street.
Turner did not immediately respond to a request from WW for comment. He told Oregon Public Broadcasting that he encouraged Wolf to get input from local police on how the feds responded. "Everybody discussed different things. My part of the discussion was, I hope they would make a connection with PPB and Chief Lovell to coordinate how they work together," Turner said.
The person in the photo with Wolf, however, is not Turner. Neither the mayor's office nor the Police Bureau could immediately answer who the person was.
The question of whether police are meeting with Homeland Security is significant because local elected officials have spurned federal assistance but have not clarified if and to what degree local and federal law enforcement continue to coordinate their response to nightly demonstrations. The White House created a new task force, staffed by U.S. Border and Customs Enforcement officers, to protect federal buildings and monuments. It's not clear if that task force has any communication with local police agencies.
Meanwhile, both federal and local police forces confronted protesters last night, on both sides of the Willamette River. In downtown, federal officers used tear gas to scatter a crowd near the courthouses. On Northeast 47th Avenue and Burnside Street, Portland police charged a crowd of demonstrators and arrested a local journalist, regular WW correspondent Andrew Jankowski.
Jankowski tells WW he was standing in the street when officers charged, and identified himself as media before his arrest.
"While I didn't see the two people who pushed me, they felt like they were wearing armor," he says. "I am underweight and fell quickly. There is an ongoing restraining order keeping PPB from interfering with journalists, and I don't understand how my arresting officer couldn't have known I am a journalist."


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Some asks start up and have 50 followers within the first few weeks…
Some are flooded with asks…
Some of their characters are loved and envied by all…
Some have amazing art skills…
Some have many characters and friends…
Some know how to roleplay better than anyone else…
A character can still be a great character without being a good person.
In fact, some of the best characters are terrible people.
Because a character’s worth should be based on how complex and interesting they are, not their morality if they were real.
fall is almost here guys
I didn’t think this gif could be used properly with anything. I was wrong.
Canada skipped fall here and went straight to effin winter. Thank goodness it melted somewhat.
Isn’t it always winter in canada
Well, i wouldn’t be here if it was
So do you not have polar bears as pets either
Certainly not xD i’d probably be dead
did you know when you suddenly jerk awake while falling asleep, another version of you from a different timeline just died
This post fucked me up.
It’s actually because you’re heart rate decreased so quickly that you’re brain jerks you awake to make sure you’re still alive.
i dont know wHICH ONE IS WORSE
I’ve been looking for an answer :’D
For those who are going to a new high school, starting college, or just wanting to start this school year anew, here are some very simple tips that will change your routines for the better! As simple as some of these may sound, we all need to be reminded every now and then that your education and your well being is of highest priority, and to do that, you must know what kind of help is available to you, how to be yourself, and how to reduce as much stress as possible! I wish I could have covered more but there was no more space in my comic, so feel free to add any other tips if you’d like! I hope you guys will have a wonderful school year. uwu
The tutorial of how I achieve watercolor effect in Sai! :) I highly recommend using real watercolor paintings (your own or ones found on the internet) as reference.
And here you can find a few useful links:
- You can download the Sai file of this picture here: link
- Video process of painting another picture: link
- The old watercolor tutorial: link
- Sai brushes (none of them is made by me) link + file you need to open them in Sai: link
- Awesome watercolor brushes made by Kyle T Webster: link
Here’s the finished painting: link
Yesyesyes, I need this for graphic novel writing
All these pages are 8.5x11, 300 dpi. Feel free to print it out in full size if you like physical copies
Comics and Comic Artists
Scott McCloud’s “Making Comics” (entirely done in comic format)
Necklaces by RubyRobinBoutique.


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Key quotes from macbeth shakespeare macbeth key quotes: speaker, significance, themes study shows his growing ambition (he's not happy being king, but he also wants kids to be kings) theme: ambition the power of man, for none of woman born shall harm macbeth (41. Slow down there, macbeth, because these ladies haven't said a word about murder the fact that his first thought is about killing the king is mighty suspicious—almost as though they've just awoken a murderous ambition that's been there all along. Ambition and power were two qualities that, collectively, did not bring about macbeth’s downfall macbeth most definitely had a thirst for power, his ambition was strong and ruthless and the world inevitably reciprocated such ruthlessness. When ambition fuels your desire to succeed, you’re virtually unstoppable there’s this undeniable hunger that leads you to passionate action—and as goals go, it’s the doing that leads to.
Synonyms for ambition at thesauruscom with free online thesaurus, antonyms, and definitions find descriptive alternatives for ambition. Ambition definition is - an ardent desire for rank, fame, or power how to use ambition in a sentence ambition has roots in roman politics synonym discussion of ambition an ardent desire for rank, fame, or power desire to achieve a particular end the object of ambition. The tragedy of macbeth by william shakespeare is a perfect example of the tragic flaw of over ambition and the desire for power the three points that show this theme are lady macbeth and the 3 witches’ power over macbeth , the murder of king duncan, and lastly the murder of banquo. Power and ambition are both major themes in the tragedy of julius caesar after all, one need only read as far as the exposition to discover the grumblings of the social elite against those in.
Power quotes mind quotes ambition quotes goals quotes passion quotes motivation quotes our work is directly proportional to the distances our dreams travel across, as force (power) is a constant factor. Frequently the driving ambition to reach a certain goal is the results of the psychological state of “sublimation” certain forms of substitution are involved in the process of sublimation it involves the diverting of a primitive instinctual drive into a more noble, exalted or culturally higher activity. Power and ambition julius caesar referat by massimo, max, jens and nico do you think there are circumstances where it can be justified to assassinate a tyrant. Success and failure is more closely linked to ambition than any other 'emotion' the power of will is ambition i can and i will are very important affirmative statements those who are not afraid to fail will do whatever it takes to continue trying, passing through many failures on the way to.
Best english songs 2018 hits | most popular songs of 2018 | best music 2018 | magic box stream 24/7 magic box 1,602 watching live now. Ambition definition, an earnest desire for some type of achievement or distinction, as power, honor, fame, or wealth, and the willingness to strive for its attainment: too much ambition caused him to be disliked by his colleagues see more. To live with ambition is to live in fear and anxiety, unless, that is, the weight of our ambition can be relieved by gratitude, which is the feeling of appreciation for past and present goods.
John armour hindman 4th 5/13/10 power ambition and honor the fact is power corrupts, unless one knows how to use it everyone has ambition it is the desire for achievement and the willingness to strive for its attainment. Many of my readers have asked which books i would recommend that offer fundamental insights into the drive for personal power, and the way it affects individuals. The main theme of macbeth—the destruction wrought when ambition goes unchecked by moral constraints—finds its most powerful expression in the play’s two main characters macbeth is a courageous scottish general who is not naturally inclined to commit evil deeds, yet he deeply desires power and advancement.
Shakespeare's famous play, ''macbeth,'' centers around a struggle for power and the plight of ambition this interactive quiz, which may also be. The power of ambition if you study high achievers and what makes them successful in life, you will always find that they have a lot of drive, a lot of ambition to succeed in webster’s dictionary ambition is defined as “a strong drive for success. The motor that drives the tragedy of shakespeare's macbeth is the lead character’s ambition it is his primary character flaw and the personality trait that enables this brave soldier to murder his way to take the throne.
In macbeth, shakespeare depicts the tragic consequences of macbeth’s lust for power whilst initially an honourable and loyal soldier, and full of the “milk of human kindness”, macbeth’s “vaulting” ambition to become king leads to the murder of the honourable king duncan. The power to manipulate energies derived from willpower and/or ambition sub-power of indomitable will not to be confused with willpower manipulation the users of this power can manipulate energy formed from their ambitious strength and willpower to be enable them to achieve feats such as. Families are time-honored sources of virtues and values but what if a family’s greatest virtue is its thirst for power this seminar will examine five families whose members obtained positions at the highest levels of society: the medicis, tudors, and bonapartes in europe, and the kennedys and clintons in the united states. Notice how lady macbeth uses the word crown, this shows that the witches, in form of spirits, have filled lady macbeth with ambition more vaulting than macbeth’s one under the influence the witches she is driven to extreme measures: “come thick night and pall thee in the dunnest smoke of hell”.


Car dealer David Flynn recently visited the Detroit-Hamtramck Assembly plant to grab his Caddy CT6.
The 2016 Cadillac CT6
is nearly ready to launch in the United States, but the winner of the first production 2016 Cadillac CT6 has taken delivery of the first example.
Last April, Car dealer David Flynn of Columbiana, Ohio, bid the sum of $200,000 for the right to purchase the first retail production model of the 2016 Cadillac CT6 sedan.
The News Wheel article here


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The activation of protein tyrosine kinases is a critical event in T cell antigen receptor (TCR)-mediated signaling. One substrate of the TCR-activated protein tyrosine kinase pathway is a 76-kDa protein (SLP-76) that associates with the adaptor protein Grb2. Northern analysis demonstrates that SLP76 mRNA is expressed solely in peripheral blood leukocytes, thymus, and spleen; and in human T cell, B cell and monocytic cell lines. In vitro translation of SLP76 cDNA gives rise to a single product of 76 kDa that associates with a GST/Grb2 fusion protein, demonstrating a direct association between these two molecules. It has been reported that this novel protein is likely to play an important role in TCR-mediated intracellular signal transduction (1). It has been shown that SDF-1alpha stimulation of prolonged ERK activation in Jurkat T cells requires both the ZAP-70 tyrosine kinase and the Src homology 2 domain-containing leukocyte protein of SLP-76 scaffold protein. This pathway involves ZAP-70-dependent tyrosine phosphorylation of SLP-76 at one or more of its tyrosines, 113, 128, and 145 (2).
* Shipping is in business days
* OriGene provides validated application data and protocol, with money back guarantee.


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State officials are expected today to release lackluster reading scores for city elementary schoolers, but that didn't stop Mayor Bloomberg yesterday from touting near-perfect success in improving the schools.
"By virtually every objective measure - attendance, promotion rates, test scores, you name it - student achievement is on the rise," the mayor said as he released City Hall's version of the 2006 graduation rate.
City officials put the graduation rate at a record-breaking 60% because they include kids who graduate in August after summer school, kids who drop out and earn GEDs and special education students who earn individualized diplomas.
The announcement came a month after state officials put the city's graduation rate at 50%, using stricter criteria.
The city and state use different methods, but Bloomberg insisted, "Using any yardstick, graduation rates in our schools are at record highs."
It's happy news, but the timing of the speech a day before the release of reading scores raised the eyebrows of critics.
"They've expended a huge amount of energy on maintaining the idea that things have substantially improved as a result of their reforms," said Sol Stern of the Manhattan Institute.
"In the past, their data has been disproved, and you begin to distrust them on everything they put out. It's all driven by the mayor's political agenda," Stern said.
Asked about the reading scores yesterday, Bloomberg suggested people look at eighth-grade scores.
"Middle school - that's always been a problem, so if eighth-grade scores are starting to go up that should put a big smile on our face."
Sources familiar with the scores said they're down in elementary school, but up in eighth grade.


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Grasslands absorb and release carbon dioxide (CO2), emit methane (CH4) from grazing livestock, and emit nitrous oxide (N2O) from soils. Little is known about how the fluxes of these three greenhouse gases, from managed and natural grasslands worldwide, have contributed to past climate change, or the roles of managed pastures versus natural grasslands. Here, global trends and regional patterns of the full greenhouse gas balance of grasslands are estimated for the period 1750 to 2012. A new spatially explicit land surface model is applied, to separate the direct effects of human activities from land management and the indirect effects from climate change, increasing CO2 and regional changes in nitrogen deposition. Direct human management activities are simulated to have caused grasslands to switch from a sink to a source of greenhouse gas, because of increased livestock numbers and accelerated conversion of natural lands to pasture. However, climate change drivers contributed a net carbon sink in soil organic matter, mainly from the increased productivity of grasslands due to increased CO2 and nitrogen deposition. The net radiative forcing of all grasslands is currently close to neutral, but has been increasing since the 1960s. Here, we show that the net global climate warming caused by managed grassland cancels the net climate cooling from carbon sinks in sparsely grazed and natural grasslands. In the face of future climate change and increased demand for livestock products, these findings highlight the need to use sustainable management to preserve and enhance soil carbon storage in grasslands and to reduce greenhouse gas emissions from managed grasslands.
Climate warming from managed grasslands cancels the cooling effect of carbon sinks in sparsely grazed and natural grasslands
Join us this autumn for a series of webinars led by Oxford Net Zero fellows! Read more
Professor Myles Allen appointed Fellow of the Royal Society Read more
Oxford Net Zero has an exciting opening for a Research Fellow on Net Zero for the Fossil Fuel Sector and non-stipendiary Research Fellowship at Kellogg College. We are seeking to appoint a Research Fellow on Net Zero for the Fossil Fuel Sector ... Read more
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domain: agronomy