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Category Archives: Gene Medicine
WASHINGTON, July 19, 2021 /PRNewswire/ --A recently published article in Experimental Biology and Medicine (Volume 246 Issue 13, July, 2021)describes a new genetic mutation linked to hearing impairment. The study, led by Dr. Ambroise Wonkam in the Division of Human Genetics, Faculty of Health Sciences at the University of Cape Town (South Africa), reports a variant of the DMXL2 gene in Cameroonian families with hearing impairment.
The inability to hear properly in one or both ears impacts nearly 6% of the global population. Hearing impairment can be caused by environmental or genetic factors. However, establishing a definitive genetic cause can prove difficult in some cases. Approximately 70% of genetic related hearing impairment cases are non-syndromic and occur without the presence of other clinical factors. Over 120 genes have been linked to non-syndromic hearing impairment.While most cases in Europe and Asia can be traced to variants in a single gene, the GJB2 gene, the etiology of African non-syndromic hearing impairment cases is unresolved.
In this study, Dr. Wonkam and colleagues used direct sequencing methods to analyze DNA samples from a Cameroonian family with non-syndromic hearing impairment (NSHI). A mono-allelic missense variant [NM_015263.5:c.918G>T; p.(Q306H)] was identified in the DMXL2 gene in this family.This variant was present in the heterozygous state in the affected mother and the two affected children (one male and one female), and absent from the other two unaffected children (one male and one female). The variant was absent from many genome databases, over 120 control individuals from Cameroon, and 112 isolated cases of NSHI from Cameroon. This is the first report implicating DMXL2 in NSHI in Africans and confirms a previous report of this variant in China.Dr. Wonkam said, "DMXL2 is now a confirmed NSHI candidate gene in Cameroon, and more studies are needed to assess its implication in other populations around the world."
Dr. Steven R. Goodman, Editor-in-Chief of Experimental Biology & Medicine, said "Dr. Wonkam and colleagues have identified a mono-allelic variant in DMLX2, also called rabconnectin-3a (RC3), in a Cameroonian family with hearing impairment. A similar variant was previously found in a Han Chinese family. It is very interesting that RC3 is found on inner ear hair cells and is a part of a synaptic vesicle protein complex involved in Ca2+-dependent neurotransmitter release in brain. Future studies aimed at a detailed understanding of the role of DMXL2 in hearing impairment is warranted."
Experimental Biology and Medicine is a global journal dedicated to the publication of multidisciplinary and interdisciplinary research in the biomedical sciences. The journal was first established in 1903. Experimental Biology and Medicine is the journal of the Society of Experimental Biology and Medicine. To learn about the benefits of society membership visit http://www.sebm.org. If you are interested in publishing in the journal, please visit http://ebm.sagepub.com.
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Advances in the Genetic Etiology of Hearing Impairment - PRNewswire
funded study finds gene therapy may restore missing enzyme in rare disease – National Institutes of Health
Friday, July 16, 2021
Results provide hope for children with aromatic L-amino acid decarboxylase deficiency.
A new study published in Nature Communications suggests that gene therapy delivered into the brain may be safe and effective in treating aromatic L-amino acid decarboxylase (AADC) deficiency. AADC deficiency is a rare neurological disorder that develops in infancy and leads to near absent levels of certain brain chemicals, serotonin and dopamine, that are critical for movement, behavior, and sleep. Children with the disorder have severe developmental, mood dysfunction including irritability, and motor disabilities including problems with talking and walking as well as sleep disturbances. Worldwide there have been approximately 135 cases of this disease reported.
In the study, led by Krystof Bankiewicz, M.D., Ph.D., professor of neurological surgery at Ohio State College of Medicine in Columbus, and his colleagues, seven children received infusions of the DDC gene that was packaged in an adenovirus for delivery into brain cells. The DDC gene is incorporated into the cells DNA and provides instructions for the cell to make AADC, the enzyme that is necessary to produce serotonin and dopamine. The research team used magnetic resonance imaging to guide the accurate placement of the gene therapy into two specific areas of the midbrain.
Positron emission tomography (PET) scans performed three and 24 months after the surgery revealed that the gene therapy led to the production of dopamine in the deep brain structures involved in motor control. In addition, levels of a dopamine metabolite significantly increased in the spinal fluid.
The therapy resulted in clinical improvement of symptoms. Oculogyric crises, abnormal upward movements of the eyeballs, often with involuntary movements of the head, neck and body, that can last for hours and are a hallmark of the disease, completely went away in 6 of 7 participants. In some of the children, improvement was seen as early as nine days after treatment. One participant continued to experience oculogyric crises, but they were less frequent and severe.
All of the children exhibited improvements in movement and motor function. Following the surgery, parents of a majority of participants reported their children were sleeping better and mood disturbances, including irritability, had improved. Progress was also observed in feeding behavior, the ability to sit independently, and in speaking. Two of the children were able to walk with support within 18 months after receiving the gene therapy.
The gene therapy was well tolerated by all participants and no adverse side effects were reported. At three to four weeks following surgery, all participants exhibited irritability, sleep problems, and involuntary movements, but those effects were temporary. One of the children died unexpectedly seven months after the surgery. The cause of death was unknown but assessed to be due to the underlying primary disease.
Jill Morris, Ph.D., program director, NIHs National Institute of Neurological Disorders and Stroke (NINDS). To arrange an interview, please contact email@example.com
Pearson TS et al., Gene therapy for aromatic L-amino acid decarboxylase deficiency by MR-guided direct delivery of AAV2-AADC to midbrain dopaminergic neurons, Nature Communications, July 12, 2021. https://doi.org/10.1038/s41467-021-24524-8
This study was supported by NINDS (R01NS094292, NS073514-01).
The NINDS NINDS is the nations leading funder of research on the brain and nervous system.The mission of NINDS is to seek fundamental knowledge about the brain and nervous system and to use that knowledge to reduce the burden of neurological disease.
About the National Institutes of Health (NIH):NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.gov.
NIHTurning Discovery Into Health
Companies associated with gene-editing are near the end of their second poor week in a row on Wall Street. For the week, shares of CRISPR Therapeutics (NASDAQ:CRSP) were down by 12% as of Thursday's market close. Editas Medicine (NASDAQ:EDIT) was off by about 14% over those four days, and Beam Therapeutics (NASDAQ:BEAM) had lost 15%.
Those downward moves came on the heels of a huge June run-up after Intellia Therapeutics (NASDAQ:NTLA) -- another gene-editing company -- announced that its approach had successfully reversed a genetic disease in human patients. In a clinical trial first, researchers injected a CRISPR treatment into patients that effectively inactivated the body's production of a mutated (and eventually toxic) form of a protein by altering the patients' DNA. Intellia and its partner Regeneron will now navigate the standard regulatory review process. Intellia CEO John Leonard has said he hopes the therapy becomes available to patients "very, very soon." However, marketability could still be years away. Meanwhile, Wall Street's recent surge of excitement about CRISPR therapies has worn off.
BEAM data by YCharts
The drops are notable as investors initially saw this breakthrough result as a positive for all gene-editing stocks. CRISPR Therapeutics, Editas, and Intellia are all taking similar approaches to editing genes -- using the CRISPR-Cas9 enzyme, which functions like a scissors. Beam Therapeutics, on the other hand, uses base-editing, an approach that alters DNA more like a pencil and eraser. Nearly three weeks removed from Intellia's announcement, the market has clearly decided its breakthrough is much more company-specific.
Image source: Getty Images.
It appears gene-editing investors who don't hold Intellia will have to wait for their own companies' catalysts to see big gains. Of these three, CRISPR Therapeutics is the one whose lead candidate is furthest along in clinical trials. CRISPR and its partner, Vertex Pharmaceuticals, have dosed more than 40 patients in a trial studying CTX001 in patients with sickle cell and beta-thalassemia. All patients at least three months removed from the procedure have shown a consistent and positive response to CTX001. Every previously transfusion-dependent patient in the trial has become transfusion-free since receiving the one-time treatment.
CTX001 is currently in a phase 1/2 study, and CRISPR Therapeutics hasn't offered any estimates about when it anticipates that it could be commercially available. But it recently signed an agreement with a smaller startup, Capsida Biotherapeutics, to develop an in vivo therapy for two diseases -- amyotrophic lateral sclerosis (ALS) and Friedreich's ataxia.
Editas has both in vivo and ex vivo (gene-editing done outside the body) candidates in early-stage clinical trials. Its in vivo candidate, EDIT-101, is a treatment for the most common form of childhood blindness. For this program, management has a meeting scheduled with the independent data monitoring committee this summer, and plans to share clinical data by the end of the year.
The company's also developing an ex vivo treatment for sickle cell disease that takes a slightly different approach than the one being used by other gene-editing companies. Editas is using the Cas12a enzyme instead of the more commonly used Cas9. The Cas12a approach has shown better editing efficiency in some studies and only requires one RNA molecule for editing as opposed to Cas9, which requires two.
For now, Beam Therapeutics is furthest back on the research and development path. Its programs are in preclinical stages. Its most advanced candidate also targets sickle cell disease and beta-thalassemia.
Investors' excitement about Beam has been less about its individual treatments and more about the gene-editing technology the company is using. Its base-editing approach could offer a more precise and predictable tool to modify DNA for treating diseases. The company hopes that will allow it to effectively leapfrog its rivals in the next few years. Management has predicted it will file with the FDA for an investigational new drug (IND) designation for its lead candidate later this year. Receiving that designation will give it the green light to test the treatment in humans trials. It also plans to move two more programs into the IND-enabling stage.
This article represents the opinion of the writer, who may disagree with the official recommendation position of a Motley Fool premium advisory service. Were motley! Questioning an investing thesis -- even one of our own -- helps us all think critically about investing and make decisions that help us become smarter, happier, and richer.
ST. LOUIS--(BUSINESS WIRE)--M6P Therapeutics (M6PT or the Company), a privately held life sciences company developing next-generation recombinant enzyme and gene therapies for lysosomal storage disorders (LSDs), today announced that it will host a key opinion leader (KOL) webinar on LSDs on Wednesday, July 28, 2021 at 10:00 a.m. ET.
The webinar will feature a fireside chat with KOLs Gregory Enns, M.D., Lucile Salter Packard Childrens Hospital Stanford School of Medicine, and Mark S. Sands, Ph.D., Departments of Medicine and Genetics at Washington University School of Medicine, who will discuss the current treatment landscape and unmet medical needs in LSDs, including Gaucher disease, Fabry disease, Pompe disease, mucopolysaccharidoses, and mucolipidoses. LSDs are a family of approximately 50 rare, genetic, and life-threatening diseases characterized by a deficiency in a specific lysosomal enzyme.
The event will also feature an update from the M6PT management team on its recombinant enzyme and gene therapy S1S3 bicistronic technology platform for the treatment of LSDs. The Company plans to initiate its first clinical program in 2022.
Dr. Enns, Dr. Sands, and M6PT management will also take questions from the audience.
To register for the webinar, please click here.
Dr. Enns is a Professor of Pediatrics and Genetics at the Lucile Salter Packard Childrens Hospital Stanford School of Medicine. He completed his medical education at the University of Glasgow (1990) in Scotland and completed his residency at the Children's Hospital Los Angeles Pediatric Residency in California. He then went on to complete his fellowship at the UCSF Medical Center in California. He is board certified in Clinical Genetics and Genomics. Dr. Enns research interests include novel means of diagnosing and treating mitochondrial disorders, with an emphasis on antioxidant therapy, lysosomal disorders, and newborn screening by tandem mass spectrometry. His current pursuits include the analysis of glutathione and antioxidant status in patients who have mitochondrial disorders and the development of new techniques for diagnosing and treating these conditions.
Dr. Sands is a Professor in the Departments of Medicine and Genetics at Washington University School of Medicine in St. Louis. Dr. Sands received his Ph.D. in Molecular Pharmacology from the State University of New York at Stony Brook. He was a postdoctoral fellow at The Jackson Laboratory (Bar Harbor, ME) and at the University of Pennsylvania School of Veterinary Medicine before joining the faculty at Washington University School of Medicine. The goals of Dr. Sands laboratory are to better understand the underlying pathogenesis and developing effective therapies for inherited childhood diseases, specifically LSDs. A major focus of his group is to determine the safety and efficacy of adeno-associated viral gene transfer vectors for the treatment of both the central nervous system (CNS) and systemic manifestations of these diseases. In addition, his group has developed lentiviral-mediated hematopoietic stem cell-directed gene therapy approaches, as well as small molecule drugs, and more recently rational combinations of these approaches. The primary diseases that Dr. Sands studies are mucopolysaccharidosis type VII (MPS VII), Krabbe disease, and Infantile Neuronal Ceroid Lipofuscinosis.
About M6P Therapeutics
M6P Therapeutics is a privately held, venture-backed biotechnology company developing the next-generation of targeted recombinant enzyme and gene therapies for lysosomal storage disorders (LSDs). M6P Therapeutics proprietary S1S3 bicistronic platform has the unique ability to enhance phosphorylation of lysosomal enzymes for both recombinant enzyme and gene therapies, leading to improved biodistribution and cellular uptake of recombinant proteins and efficient cross-correction of gene therapy product. This can potentially lead to more efficacious treatments with lower therapy burden, as well as new therapies for currently untreated diseases. M6P Therapeutics team, proven in rare diseases drug development and commercialization, is dedicated to fulfilling the promise of recombinant enzyme and gene therapies by harnessing the power of protein phosphorylation using its S1S3 bicistronic platform. M6P Therapeutics mission is to translate advanced science into best-in-class therapies that address unmet needs within the LSD community. For more information, please visit: http://www.m6ptherapeutics.com.
Leading Gene Writing Company Tessera Therapeutics Announces Pivotal Expansion of Leadership Team – Business Wire
CAMBRIDGE, Mass.--(BUSINESS WIRE)--Tessera Therapeutics, a biotechnology company pioneering a new approach in genetic medicine known as Gene Writing, announced today the appointment of Howard Liang, Ph.D., as President and Chief Financial Officer. The company also expanded its executive bench with newly promoted talent and hires: Madhusudan Peshwa, Ph.D., as Chief Technology Officer for Cell Therapy; Bill Querbes, Ph.D., as Senior Vice President, Therapeutic Discovery & Translational Sciences; Cecilia Cotta-Ramusino, Ph.D. as Senior Vice President, Platform Development; Vikram Ranade, Ph.D., as Senior Vice President, Corporate Development; David Pollard, Ph.D., as Head of Bioprocess, and Steve Garbacz as Head of Finance.
These additions represent the latest leadership expansion for the company, following the appointments of Elliott Sigal, M.D., Ph.D., and Mary Rozenman, Ph.D., to the Board of Directors in June, and the appointments of David Davidson, M.D., as Chief Medical and Development Officer, Hari Pujar, Ph.D., as Chief Operating Officer, and Lin Guey, Ph.D., as Senior Vice President of Rare Diseases Program Strategy and Operations in March. Tessera also announced the successful completion of $230 million Series B financing in January.
Outstanding people are the lifeblood of great companies and Im thrilled to welcome these accomplished individuals to the Tessera leadership team, said Dr. Geoffrey von Maltzahn, CEO and Co-Founder of Tessera and General Partner, Flagship Pioneering. Howards track record in both strategy and finance at BeiGene and in the capital markets will play a key role in guiding Tessera to new territory in Gene Writing. I am excited to be working with him, and our other new senior leaders, each of whom will be instrumental in expanding the limits of how we discover life-changing medicines.
Howard Liang, Ph.D., President and Chief Financial OfficerHoward Liang joined Tessera in 2021 as President and Chief Financial Officer. Dr. Liang brings nearly three decades of combined experience in management, financing, strategy, and research in the biotechnology and pharmaceutical industries and investment research on Wall Street. Prior to joining Tessera, he was Chief Financial Officer and Chief Strategy Officer at BeiGene for six years, where he was a member of the senior team that led the companys growth from a research organization with fewer than 200 employees to a fully integrated global biotechnology company with more than 6,000 employees on five continents. At BeiGene, he led the companys IPOs on NASDAQ and the Hong Kong Stock Exchange and its ongoing effort to list on the Shanghai Stock Exchange, raising more than $8 billion to date through equity and alternative financings, and overseeing the growth of the companys market capitalization from less than $300 million to more than $30 billion during his tenure. Prior to BeiGene, Dr. Liang spent 10 years at Leerink Partners, where he was Managing Director and Head of Biotechnology Equity Research. His prior investment research experience included positions at A.G. Edwards, JMP Securities, and Prudential Securities, covering biotechnology, and major and specialty pharmaceutical sectors. He started his career in R&D at Abbott Laboratories, where he was a Senior Scientist and member of an industry-leading structure-based drug discovery team. Dr. Liang is a member of the Hong Kong Stock Exchange Biotech Advisory Panel. He was named a member of the All-America Research Team by Institutional Investor magazine and Best of the Street by The Wall Street Journal. As a scientist, he authored 14 papers, including 6 in Nature, Science, and Proceedings of the National Academy of Sciences, and a review in the Journal of Molecular Biology. He received his Ph.D. in Biochemistry and Molecular Biology and M.B.A. from the University of Chicago and his B.S. in Chemistry from Peking University.
Tessera is developing a first-of-its-kind technology with the potential to cure diseases across multiple categories by writing in the code of life itself, said Dr. Howard Liang. I look forward to helping the company realize the full breadth of Gene Writings potential.
Madhusudan Peshwa, Ph.D., Chief Technology Officer for Cell TherapyDr. Peshwa joined Tessera in May 2021 and is responsible for developing the strategy and executing the operating plan encompassing the design, development, and manufacture of Tesseras proprietary mobile gene element engineered cell therapy product portfolio. Recently, in March 2020, Dr. Peshwa was inducted into the College of Fellows at the American Institute for Medical and Biological Engineering (AIMBE), in recognition of Lifetime contributions in Regenerative Medicine to the advancements in the field of cell & gene therapies.
Prior to joining Tessera, Dr. Peshwa was CTO at Mana Therapeutics, an immunotherapy company focused on the development of allogeneic, multi-tumor-antigen-targeted, non-engineered, T-cell immunotherapies with additional oversight of Quality Assurance and Quality Control functions. Previously, Dr. Peshwa was CTO and Global Head of R&D for the Cell and Gene Therapies business at GE Healthcare (GEHC), with responsibilities that include GEHCs CGT product and service portfolio to enable and accelerate the development of robust, scalable, industrialized manufacturing and delivery of cell and gene therapies. Prior to these roles, Dr. Peshwa held various executive positions at MaxCyte, Inc., NewNeural LLC, and Dendreon Corporation. At MaxCyte, as CSO and EVP, Cellular Therapies, Dr. Peshwa was responsible for leading the development and commercialization of ex vivo cell loading platform technology. Additionally, he also established MaxCytes proprietary therapeutic product portfolio with lead program being a non-viral mRNA engineered CAR Immunotherapy (CARMA) with one-day manufacturing process under company sponsored IND for treatment of solid cancers; and additional collaborative programs under CRADA Agreement with Investigators at NIAID and NHLBI, for ex vivo gene correction in autologous hematopoietic stem cells, as cell therapy for potential treatment of monogenic diseases. As Vice President of Process Sciences and Manufacturing, at Dendreon Corporation, Dr. Peshwa was responsible for leading the CMC and GMP manufacturing for Provenge (Sipuleucel-T), an autologous cellular immunotherapy product for treatment of prostate cancer, the first ever active cellular immunotherapy product approved by the US FDA.
In addition to his broad industry experience, Dr. Peshwa has served as Principal Investigator / Co-Investigator on multiple grant-funded research studies, is an inventor of six issued US patents in the field of cell therapy, and has served in various consultative, advisory, and board capacities to industry, government, not-for-profit, and financial organizations. Dr. Peshwa earned his Ph.D. in Chemical Engineering from the University of Minnesota and his B.Tech. in Chemical Engineering from the Indian Institute of Technology in Kanpur, India.
Tesseras Gene Writing platform represents an opportunity to drive a fundamental change in our ability to treat disease, said Dr. Madhusudan Peshwa. I look forward to joining the executive team to help move Tesseras bold mission forward.
Bill Querbes, Ph.D., Senior Vice President, Therapeutic Discovery & Translational SciencesBill Querbes joined Tessera in April of 2021 as Senior Vice President of Therapeutic Discovery and Translational Sciences. He brings a strong background in genetic medicine and a passion for rare disease drug development with over 15 years of experience leading cross-functional teams from early discovery through clinical trials.
Before joining Tessera, Dr. Querbes held the position of Vice President and Fabry Program Lead at AVROBIO. Prior to this role, as Senior Director at Synlogic, he led clinical program teams in PKU and urea cycle disorders. Earlier in his career he spent 12 years at Alnylam Pharmaceuticals where he made important contributions to the maturation of both the siRNA delivery platforms and therapeutic pipeline. Dr. Querbes led the discovery and early clinical development of GIVLAARI (givosiran) for the treatment of acute hepatic porphyria, which was the first FDA approved RNAi therapeutic utilizing GalNAc conjugate technology.
He holds a B.S. in Biology from SUNY Geneseo and a Ph.D. from Brown University.
Cecilia Cotta-Ramusino, Ph.D., Senior Vice President, Platform DevelopmentCecilia Cotta-Ramusino joined Tessera in 2019 as the Head of Platform Development. She drives the discovery and optimization of novel Gene Writers, enabling their translation into gene therapy tools. Dr. Cotta-Ramusino has spent more than 20 years in academia and biotech, working in the areas of gene editing, cell engineering, and DNA damage. Dr. Cotta-Ramusino was the first employee at insitro where she was the Head of Functional Genomics. Prior to insitro, she was one of the first scientists hired at Editas, the first CRISPR-based therapeutic company, where she helped to define and shape the vision of the Editas platform. She spearheaded numerous academic collaborations devoted to platform optimization and led the development of a T cell gene therapy treatment aiming to treat an immunodeficiency disease. She conducted her postdoc in Steve Elledges lab at Harvard Medical School where she performed whole genome high-throughput screens in mammalian cells using siRNA/shRNA to identify novel components of the DNA damage response. Dr. Cotta-Ramusino obtained her Ph.D. in genetics at University of Milan, Italy and has been principal author and co-author on several publications in high impact factor journals, such as Science, Nature, Nature Communications and Molecular Cell. She has invented several foundational patents in all of the early-stage companies in which she has worked.
Vikram Ranade, Ph.D., Senior Vice President, Corporate DevelopmentDr. Ranade joined Tessera in 2020 as the Head of Corporate Development. In this role, he drives corporate strategy, business development, and investor relations for Tessera.
Dr. Ranade was previously at McKinsey & Company, where he was an Associate Partner in the healthcare practice. At McKinsey, he worked with large biopharma and early-stage biotech companies on strategy, M&A, and R&D topics. He led diligence efforts for more than $15B in completed deals and advised on clinical strategy for more than 20 programs. Dr, Ranade also co-led McKinseys Center for Asset Optimization, which focuses on clinical-stage asset development strategy. He holds a Ph.D. in Genetics and Development from Columbia University, where he studied transcriptional regulation of developmentally important genes at the molecular level. He has a B.S. in biochemistry from Brandeis University, where he was awarded highest honors for his research on DNA damage repair pathways.
David Pollard, Ph.D., Head of BioprocessDavid Pollard has over 25 years of bioprocess development for a range therapeutics including novel mAbs, peptides, anti infectives, biocatalysts and more recently cell and gene therapies. During his career at Merck & Co. Inc, Dr. Pollard led early and late stage CMC teams, providing contributions to multiple INDs & BLAs for Biologics & Vaccines. Dr. Pollard also led an innovation team that co-developed the state-of-the-art ambr250 high throughput bioreactor system and also pioneered lights out automated continuous mAb production. More recently Dr. Pollard pursued processing for personalized neoantigen T cell therapies and helped create corporate research for the technology provider Sartorius. Dr. Pollard will help Tessera drive digital workflows and high throughput automation to accelerate sustainable gene therapy process development.
Steve Garbacz, Head of FinanceSteve Garbacz joined Tessera in 2021 as the Head of Finance and is responsible for financial reporting, planning, taxes, and treasury. Garbacz has more than 25 years of experience in financial management for a range of companies, including Biogen, Epizyme, Spero, and Anika. He has a passion for building scalable financial organizations leveraging new technology, and drove successful IPOs at Epizyme and Spero. At Anika, Garbacz was a key leader in acquiring and integrating two private companies. Garbacz has a B.S. in Economics from George Mason University and an MBA in Finance from the Leonard Stern School of Business at New York University.
For more information about Tessera, including how Gene Writing works, partnership opportunities, and job openings, visit http://www.tesseratherapeutics.com.
About Tessera TherapeuticsTessera Therapeutics is an early-stage life sciences company pioneering Gene Writing, a new biotechnology designed to offer scientists and clinicians the ability to write small and large therapeutic messages into the genome, thereby curing diseases at their source. Gene Writing holds the potential to become a new category in genetic medicine, building upon recent breakthroughs in gene therapy and gene editing while eliminating important limitations in their reach, utilization, and efficacy. Tessera Therapeutics was founded by Flagship Pioneering, a life sciences innovation enterprise that conceives, resources, and develops first-in-category bioplatform companies to transform human health and sustainability.
Your Healthy Family: New gene therapy providing hope for those with rare genetic disorders – KOAA.com Colorado Springs and Pueblo News
COLUMBUS, OHIO A novel method of gene therapy is helping children born with a rare genetic disorder called AADC deficiency that causes severe physical and developmental disabilities. The study, led by researchers at The Ohio State University Wexner Medical Center and The Ohio State University College of Medicine, offers new hope to those living with incurable genetic and neurodegenerative diseases.
Research findings are published online in the journal Nature Communications.
This study describes the findings from the targeted delivery of gene therapy to midbrain to treat a rare deadly neurodevelopmental disorder in children with a neurogenetic disease, aromatic L-amino acid decarboxylase (AADC) deficiency characterized by deficient synthesis of dopamine and serotonin.
Only about 135 children worldwide are known to be missing the enzyme that produces dopamine in the central nervous system, which fuels pathways in the brain responsible for motor function and emotions. Without this enzyme, children lack muscle control, and are usually unable to speak, feed themselves or even hold up their head. They also suffer from seizure-like episodes called oculogyric crises that can last for hours.
Remarkably, these episodes are the first symptom to disappear after gene therapy surgery, and they never return, said study co-author Dr. Krystof Bankiewicz, professor of neurological surgery at Ohio State College of Medicine who leads the Bankiewicz Lab. In the months that follow, many patients experience life-changing improvements. Not only do they begin laughing and have improved mood, but many are able to begin speaking and even walking. They are making up for the time they lost during their abnormal development.
The directed gene therapy in seven children ages 4 to 9 who were infused with the viral vector resulted in dramatic improvement of symptoms, motor function and quality of life. Six children were treated at UCSF Benioff Childrens Hospital in San Francisco and one at Ohio State Wexner Medical Center. This therapeutic modality promises to transform the treatment of AADC deficiency and other similar disorders of the brain in the future, Bankiewicz said.
During the gene therapy surgery, physicians infuse a benign virus programmed with specific DNA into precisely targeted areas of the brain. The infusion is delivered extremely slowly as surgeons monitor exactly how it spreads within the brain using real-time MRI imaging.
Really, what we're doing is introducing a different code to the cell, said Dr. James Brad Elder, director of neurosurgical oncology at Ohio State Wexner Medical Centers Neurological Institute. And we're watching the whole thing happen live. So we continuously repeat the MRI and we can see the infusion blossom within the desired nucleus.
Researchers believe this same method of gene therapy can be used to treat other genetic disorders as well as common neurodegenerative diseases, such as Parkinsons and Alzheimers disease. Clinical trials are underway to test this procedure in others living with debilitating and incurable neurological conditions.
The directed gene therapy, in these patients, resulted in dramatic improvement of symptoms, motor function and quality of life. This therapeutic modality promises to transform the treatment of AADC deficiency and other similar disorders of the brain in the future.
The findings described in this study are the culmination of decades of work by teams from multiple academic institutions, including University of California San Francisco, Washington University in St. Louis, Medical Neurogenetics Laboratory in Atlanta, St. Louis Childrens Hospital and Nationwide Childrens Hospital in Columbus, Ohio.
The research was supported by the National Institute of Neurological Disorders and Stroke and foundational grants, including the AADC Research Trust, the Pediatric Neurotransmitter Disease Association and funding from The Ohio State University.
This work provides a framework for the treatment of other human nervous system genetic diseases. Its our hope that this will be first of many ultra-rare and other neurologic disorders that will be treated with gene therapy in a similar manner, Bankiewicz said.


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On Friday, Richard Childress Racing (RCR) announced a pair of key leadership appointments, which aim to bring the company to the next level and further strengthen its business operations.
Long-time motorsports executive Mike Verlander has been named the Chief Operating Officer (COO) of Richard Childress Racing. In this new position, Verlander will work alongside Richard Childress (Chairman and CEO) and Torrey Galida (President) to provide strategic direction and oversight in the day-to-day operations of the team.
Verlander comes to Richard Childress Racing with nearly two decades of experience in the motorsports industry, plus a pre-existing relationship with NASCAR Cup Series driver Kyle Busch, who drives the team’s No. 8 Chevrolet Camaro.
Before joining RCR, Verlander worked as the President and Chief Revenue Officer of Kyle Busch Companies, where he led Kyle Busch Motorsports and managed all personal and commercial revenue for the Busch family.
Over the years, Verlander has developed a reputation for delivering results and building strategic relationships with world-class brands. In his new position, Verlander joins a C-level suite that includes Jennifer White, who has recently been appointed Chief Marketing Officer of the organization.
Having spent 15 years with Richard Childress Racing, Jennifer White is the first woman in the history of the organization to hold the Chief Marketing Officer title. White most recently served as Senior Vice President of Marketing and Communications, and will continue to lead the team’s partnership marketing, communications, content, and licensing departments.
“Mike Verlander is a highly respected industry veteran who will bring a wealth of knowledge and industry experience to RCR as he helps us chart the course for the long-term future during a very dynamic time in our sport,” said Torrey Galida, president of RCR. “I’m excited for Mike to work with the leadership team in all aspects of our business operations and know that he will do a great job. I’d also like to congratulate Jennifer White on her new position as chief marketing officer for RCR. She has done an outstanding job setting the standard for our partners and building a strong team of marketing and communications professionals.”
In November, Richard Childress Racing announced a set of promotions among its leadership team, which elevated Andy Petree to Executive Vice President, while also promoting Justin Alexander and Eric Kominek into competition-based roles.
The 2024 NASCAR Cup Series campaign begins with the pre-season Busch Light Clash at the LA Memorial Coliseum, but the work has already started in the marketing department, with several new partners announced for Busch ahead of the upcoming season including Zone Premium Nicotine Patches and Rebel Bourbon.

domain: news


By sandromiccoli November 4th, 2013
VOLT + Philips Hue Hackathon
During the Dutch Design Week in Eindhoven, VOLT organized a Hackathon in collaboration with Philips. The main goal of the event was to explore the possibilities of the Philips Hue, a wireless LED bulb that can be controlled remotely with smartphones or computer applications. The special feature of these hue lamps is that it’s open source and third-party developers are encouraged by Philips to create their own applications.
The way the event was planned was pretty straight to the point: learn how to hack the hue lights and then work on a project in a few hours to present at the end. The projects then would be evaluated by the organizers and the best ones would win Philips Hue kit’s to continue their projects.
Our team was composed by Shinichiro Ito, a design strategist from Japan and Sandro Miccoli, an interactive media developer from Brazil. Our team name is Ducere, a latin verb that means “to lead”.
During those hours, we came up with a concept called “Emotional Light”:
The hue lights understand human’s emotion by the face expression and changes their color accordingly. This system can be helpful for those who have diction problems or hearing disability to communicate with non-handicapped people with hue lights.
After prototyping this concept and presenting it we were pleased to get the second place at the Hackathon! The jury felt that this concept has a lot of potential to change the interaction with this kind of media.
VOLT made a blog post about the Hackathon here.
Here it’s possible to see a video of the Hackathon:


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Advantages of Plastic Surgery
Plastic surgery is a process used for improving the body by way of a surgery. Remember that the process is normally a healing method to make your body get back to its former glory. Note that people are getting to love plastic surgery and women and men in Marc Mani love it so that they can enhance their bodies.
Note that the procedure is not for everyone and it usually has some effect on the people who do cosmetic surgery in Marc Mani LA.Below are some benefits of plastic surgery. Maybe you have been doing a lot of exercise or trying hard to make your skin tight.Be advised that you can have a plastic surgery and the results will be instant.
Note that your skin will look younger after plastic surgery in Marc Mani California. Consider plastic surgery if you are aged forty years and above and you notice that your skin is sagging. Have in mind that, loose skin causes weight increase and skin adulterations. Be advised that you will not be able to carry out your normal duties in Marc Mani LA because you will get tired easily.Note that your skin grows old as you age and it does not matter how much cream in Marc Mani LA you will use.
Be advised that plastic surgery is good for your emotive happiness. Nowadays people are determined to get excellence.You will get some self-esteem when you decide to fight deficiencies.Numerous doctors state that looking healthier bodily will assist in getting rid of communal nervousness and it enables them to look at life positively. Note that the persons are motivated to eat a healthy diet and they also do various exercises to maintain a good shape.
Technology has made things simple and the plastic surgery procedure is normally very comfortable. Note that this process is now affordable and comfortable because of the drugs and advanced treatments.Note that the process is not for improving your skin only but it also solves body problems.
You need to exercise regularly so that you can be in good health.Note that very big boobs will make the process of searching for cancer tedious.Be advised that you will live a good life because the plastic surgery lessens most of the problems.
Though plastic surgery has numerous profits, it is vital to recall that it does not fix an individual’s life.Plastic surgery will not offer an individual a faultless body, a flawless nose or an impeccable life.
The plastic surgery procedure enhances the issues and the specialist will give you what you need.

domain: health


C & C ARTIST
C&C Maple/Poplar/Maple Custom Kit
Finish: Red Sparkle/Silver Sparkle/Red Sparkle Stripes
24” × 13" Bass Drum
13” × 9" Rack Tom
16” × 16" Floor Tom
Stephanie Bailey is an original member and the drummer for the Texas-based psych rock band, The Black Angels. Founded in 2004, they have established themselves as one of most respected bands in Experimental/Psychedelic music, having toured with The Black Keys, Black Rebel Motorcycle Club, The Warlocks, The Brian Jonestown Massacre, Queens of the Stone Age, The Raveonettes, and Wolfmother.
Wilderness of Mirrors was released last fall. The Black Angels tour the U.K. and Europe in August and the U.S. in September and October.
On C & C:


Hello again from T.I.G.E.R.S. in Myrtle Beach! Some say opposites attract but what about an orangutan being friends with a dog? Is it even possible? With Suryia and Roscoe it is!
When Suryia the orangutan first met Roscoe, a stray dog, they become best friends from the start. The two became friends when they crossed paths at T.I.G.E.R.S. Preserve. The blue tick hound was immediately spotted by the orangutan who ambled over to make friends.
Founder and Director, Doc Antle said: 'Roscoe looked really thin and a little lost so we fed him and took care of him; 'He followed us through the gate and ran over and found Suryia. As soon as he saw Roscoe, Suryia ran over to him and they started playing. It was unusual because dogs are usually scared of primates but they took to each other straight away. We made a few calls to see if he belonged to anyone and when no-one came forward, Roscoe ended up staying. Now they swim together, play together and Suryia even takes the dog for his walks.
Sounds amazing! here's a news item from just this week about other animal friends."
At Noah’s Ark, a wild-animal rescue center in Georgia, the “BLT” are an unlikely trio that even “Oz’s” Dorothy would find hard to fear.
“It’s a lion, a tiger and a bear — oh my!” said Allison Hedgecoth of Noah’s Ark. “They live together and they don’t see their differences. They don’t see their color differences.”
In a small pen, Baloo (an American black bear), Leo (the lion) and Shere Kahn (a Bengal tiger) cuddle, play ball, chase each other around, eat cookies daily and seem to have forged a friendship for life.
“It’s kind of unusual because black bears and tigers would be solitary as adults,” said Rebecca Snyder, a curator of animals at Atlanta’s zoo.
The three predators were rescued as cubs 12 years ago from drug dealers who’d abused and neglected them.
“All of them had issues,” Hedgecoth said. “Leo, the lion, had a big raw spot on his nose. Baloo, the bear, had an ingrown harness where his owners hadn’t lengthened it as he grew, so it actually grew into the skin and it had to be surgically removed. … They have recovered more than 100 percent.”
But when trainers tried to separate the animals, they acted out. For years, trainers said they worried and waited for fights but had witnessed nothing but peace among the three.
Hedgecoth said she didn’t know how the trio had managed to get along together so well and for so long.
“I think that the ordeal they went through as youngsters really bonded them together,” she told ABC News. “That’s all that they had. They only had each other for comfort.”
She said separating them now, after more than a decade together, would be “cruel.”
“There definitely is something special going on between the three of them,” she said. “That is definitely a lesson.”
Guests also enjoy wondrous experiences which live on for a lifetime in the hundreds of individual and group high end professional photographs and video we take of them on this once in a lifetime journey. They leave Preservation Station with images that only a few privileged photographers and explorers on safari have captured after years of travel; a tiger or cheetah running at full speed or swimming across a clear pool, the great apes sliding through the canopy or a large tusked elephant just a breath away. You can tell from their pictures and the letters they send us how it has changed them. This experience happens every day.
Please join in the worldwide education and conservation efforts at www.myrtlebeachsafari.com.


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Tony Brunal is an author whose professional career began in 2017 after his first published work. Since then, he’s concentrated in writing science fiction stories that highlight the human spirit and creates a loyal group of fans who eagerly await his latest releases. With every book that he envisions, Tony Brunal continues to write stories that brings people a sense of hope and redemption. His latest book is “The King’s Tower,” a suspenseful science fiction story about man’s inhumanity towards man.
My latest book, “The King’s Tower,” is a suspenseful Sci-Fi story about “Man’s inhumanity toward Man.” The story delves into some very existential questions of what people are willing to do to continue living. This book deals with some modern problems and scandals that stay on the fringes of societal norms. I have always been amazed how as human beings, we can devolve into very cold and brutal beings in order to conquer, or exploit people. After reading a story on the news about organ harvesting in other countries, it peaked my interest and researched who were the people financing this. The story evolved from that premise.
I am not an author. I have not spent countless hours at my keyboard, pouring my guts out and agonizingly hammering out the next great American novel. I know nothing of developing characters, crafting a compelling narrative, or writing beautiful and realistic dialogue. In fact, I feel a bit of an imposter to be asked to be on Writer’s Connection amongst so many accomplished, esteemed, and professional authors. I’m just a creator and an illustrator. BUT I DID PUBLISH A BOOK… And I’m damn proud of it!
My latest, and also FIRST, book is called Famous Things. It’s essentially a collection of illustrated puns based on the names of famous people who have objects for last names – a visual guessing game of sorts. In fact, I hesitate to call it a book so much as it is more like “something amusing to look at while you’re killing time on the toilet.” Perhaps, I’m not giving it enough credit. But perhaps that’s mostly due to the fact that the inspiration for it came from a joke made around the grill with a close friend of mine. We had both previously worked with the excellent actor named Gil Bellows on our film Dead Draw, and as my friend was blowing on the coals to get them going on his grill, I said “If only we had a Gil Bellows!”. Boy, did I crack myself up (it doesn’t take much)! After that, though, I couldn’t stop thinking of other celebrities with objects for last names and started drawing illustrations of those “objects.” Pure profound brilliance, right? Not so much. Just a dumb joke – but one that still makes me smile and has ended up making me a few bucks. So I guess that’s something 🙂
Judy Ringer is the author of Turn Enemies Into Allies: The Art of Peace in the Workplace—a systematic guide to help managers resolve conflict between clashing employees, and Unlikely Teachers: Finding the Hidden Gifts in Daily Conflict—a book of stories and practices on turning life’s challenges into life teachers.
Turn Enemies Into Allies: The Art of Peace in the Workplace was inspired by a series of five blog posts I wrote five years prior to the book being published. The posts offered tips and skills for managing conflict between co-workers, and is the primary content of Turn Enemies Into Allies.
I was inspired by the idea that the work I do with individuals and groups in conflict could (and should) be part of the manager’s skillset.
I’m an Aikido instructor, black belt, and founder of Portsmouth Aikido, in Portsmouth, NH. What differentiates the book is my application of Aikido principles to skills such as centering, curiosity, collaboration, and managing self in order to manage others. The illustrations by Adam Richardson also create a unique look.
Donna is the award-winning, internationally published author of six books including her most recent book As You Feel, So You Heal: A Write of Passage. She was recognized as Colorado’s “Spiritual Health Guru” by 5280 Magazine for her innovative empowerment techniques which inspire us to recognize and own our “Wisdom Story,” so we might consciously compose our next chapter.
As You Feel, So You Heal: A Write of Passage was inspired by the intersection of two of my greatest loves: being present to witness another’s golden moment of break-through, potent with realization and new growth and creating integrative ceremonies that reach into the deepest parts of ourselves. Like a traditional “rite of passage” this “write of passage” ushers the readers through a series of thresholds, helping them see things from different perspectives, so they might reveal more of their unique character. As You Feel, So You Heal encourages us to own all our emotions – to observe them, listen to them, nurture them, and address them in a way that helps them (and us) evolve, up-leveling our life’s path.
After flirting with careers as an archaeologist, pilot, concert pianist, and diplomat, Sara Frances settled on photographer after just a few month’s residence in Heidelberg, Germany, while studying for her Masters in Comparative Literature. She self-defines as a photojournalist-poet. Always a writer and reader, as well as photographer, her unique hybrid media approach blends image in a sort of illustrated, sculptural time travel. Fragments of Spirit: 60 Years: A Photographer’s Recollections of Taos Pueblo, the Region and its Arts is a sinewy braid of diverse picture stories from her longtime love affair with Northern New Mexico, plus her long-considered philosophy and methodology of making art.
Fragments of Spirit: 60 Years: A Photographer’s Recollections of Taos Pueblo, the Region and its Arts began as a promise to self and colleagues to publish my photography as art, not as in previous books where I wrote and illustrated professional expertise and techniques. At the time I could not have imagined how far reaching that goal would be, even to creating a second career. Some ten years ago I realized, while organizing my professional archive, that I had a half-century of historic, intrinsically interesting, personal images and portraits of Taos people, the Pueblo itself, the region, and artists I’ve known. At the time I unearthed just one print, but the scope of possibilities came to mind as as a flood. Also over years, I’d collected writings about my experiences, my techniques, and my philosophy of arts. I had the makings of a formal monograph—and my artistic legacy!
Trisha Watson holds a deep reverence for nature and compassion for those in need, especially animals. Of course that encompasses pets too, and thus all her dogs and cats over the years have been rescues or strays. Her first book, The Spiritual Adventures of Russell the Dog: A Blend of Truth, Fiction, and Inspiration From the Other Side, takes us on a spiritual adventure that is skillfully crafted. You will laugh, cry and possibly find answers to questions you may have contemplated in your own spiritual adventure. May you be inspired.
The Spiritual Adventures of Russell the Dog is told by none other than Russell. It is a true adventure of the spiritual kind traversing various lifetimes of a special soul (Russell) who refused his life review in a previous incarnation as a man. The journey of his soul deeply reveals the possible reason from our numerous, frequent lifetimes here on the earth plane, which is evolution of the soul.
The second part of the book’s title is: A Blend of Truth, Fiction, and Inspiration from the Other Side. It wasn’t my intention to write a book, however, I believe anything is possible. The idea began one day about my dog Russell who had made his transition. My intuition, which is sourced from Spirit Guides, angels, or God, depending on your comfort level, kept at me with mental dialogs, tied to crisp memories of my own life, beginning in childhood, and extending to present day. I resisted because the idea was so much bigger than me or my writing abilities. Plus, I didn’t want to take on the huge project of writing a book.
I have decided I am a different type of author. How I feel about writing is expressed best by Richard Bach, author of Jonathan Livingston Seagull, Illusions and many other books. Here’s how he describes the process:
“I do not enjoy writing at all. If I can turn my back on an idea, out there in the dark, if I can avoid opening the door to it, I won’t even reach for a pencil. But once in a while there’s a great dynamite-burst of flying glass and brick and splinters through the front wall and somebody stalks over the rubble, seizes me by the throat and gently says, “I will not let you go until you set me, in words, on paper.”
And that is what it takes for me to write. I must feel moved by inspiration to the point of not being able to ignore it.
Martha and Ann Driscoll
Martha and Ann Driscoll are a mother/daughter writing team who most recently lived together near the banks of the Bellamy River in Dover, New Hampshire. Between them, and thanks to the award-winning illustrations and book design of Susan Andra Lion, Martha and Ann have three award-winning books. Other titles are Sammy the Seahorse and Rosa’s Monarch Butterfly. Martha’s professional life was devoted to literacy education, reading education and the preparation of reading teachers. Ann’s professional life was a mix of teaching and leadership in higher education and organizational development consulting. Martha died on November 08, 2021. But there are still stories to write…
My mother (Martha Driscoll) and I were co-writers (she died this past November). We created three picture books, Nosey’s Wild Ride on the Belle of Louisville, Sammy the Seahorse: Is He a Horse or is He a Fish? and Rosa’s Monarch Butterfly: The Magic of Metamorphosis. At their heart, all three books are an imaginary means for early readers to learn about something that is real – an historically significant steamboat, seahorses and monarch butterflies. My mother and I began working together on picture books around 2012. The idea seed for our latest book, Rosa’s Monarch Butterfly, came from a real-life experience that my mother had seventy years ago as an elementary school teacher. A little girl who was made fun of by her peers brought a monarch chrysalis to school. The teacher turned the moment into an opportunity for the girl and her classmates to get to know one another and to learn about the monarch life cycle. In real life, the teacher was the hero who intervened in the bullying and prompted the girl’s classmates to see her differently. For our story we shook things up. We wanted the girl to be the heroine, for it to be her voice that talked about monarchs and for the book to be a resource for readers to learn about monarchs. The inspiration engine for this particular story was the tremendous satisfaction my mother and I took from writing the first two books together. We both wanted to have that experience again, the act of creating something together from our imaginations.
Julie Loar is a multiple award-winning author of eight books, dozens of articles, and a popular Blog. She has taught Astrology, Tarot, mythology and symbolism for more than forty years and traveled to sacred sites around the world, researching the material for her books and teachings, and leads sacred journeys to Egypt. She was a featured contributor on John Edward’s web site InfiniteQuest.com where she had her own internet TV show. Her newest book is Symbol & Synchronicity: Learning the Souls Language in Dreams and Waking Life.
Symbol & Synchronicity: Learning the Soul’s Language in Dreams and Waking Life is my latest book. The impulse to write the book, which at its heart is about working with dreams as guides on the spiritual path, came as a sort of “call” early in the pandemic lockdown. Over a year of writing, the journey was one of discovery and transformation. The book explores ancient dream traditions, scientific research into sleep and dreaming, cutting edge theories in quantum physics and consciousness, and wise spiritual traditions from different cultures. The book also includes a powerful and practical process for working with dreams that was triggered by an amazing dream I had while writing the book.
Susan Andra Lion
Susan Andra Lion is an award-winning designer, author, and illustrator with a full line of poetry drawings and a variety of decks of affirmation cards, journals, greeting cards, and prints. Sue is also a fine artist and works in colored pencil and pastel. Her work has been displayed in galleries, exclusive shows, and many private collections.
Fox Light, Magic Hidden in Plain Sight, was inspired by a comment made in a class I took with an elder member of my writing group way back in the 90s. She urged me to take the class, too. Sign me up, I said. By the way, what kind of class? Writing Your Memoirs, came the answer. Well, I wasn’t to the age of thinking of writing my memoirs, but the teacher was terrific. One woman in the class noted that in America, stories of “the olden days” weren’t valued. We have a history of charging ahead, even to the point of devaluing the wisdom of our older generations because of the false belief that whatever they did “back then” wasn’t productive or economically useful now. Times change. Keep up or get out of the way. All the wisdom, work ethics, problem solving, and experiences were dismissed. That led to a good class discussion about the value of passing down our stories, if only for our children and children’s children.
In the past, stories were passed down from generation to generation by the elders of the communities. The Storytellers were often the Uncles or Grandfathers, Aunts or Grandmothers. They told them over and over again to the little ones, making sure the history of the tribe was embedded deep in their hearts. Those stories became the foundation for future actions, decisions, moral stances, and pride. From oral histories came written accounts, even artwork to accompany the words. A commitment to the weaving of the community came through shared beliefs and an understanding of the earth, the plants and animals, the wind, spirit beings, and all humans.
Well, now years later, I was struck with the notion that recording experiences in my life didn’t have to be dull or outdated. I reflected on the “magical” incidences I’ve had, many of which can’t be explained with math or logic, and I started scribbling notes. One note lead to another, and the pages kept getting a little higher. Each story triggered another, until I realized I had the content for a book. Just for me, just for my children, but created with my professional approach to any job in my list.
Then, because I’m an illustrator, I felt creating drawings to augment the text was a combination of my skills. So, why not! They touched a deeper place in me – I think images do that – but I was surprised at how deep. A piece of me went way back, back to the days of being a little kid sitting at the kitchen table when we lived in North Dakota, and just drawing. I didn’t actually take an official art class until I went to college, but I was lost in bliss when I did art back then.
Fox Light is a collection of short stories based on my experiences of something magical happening in my life. I saw my beloved dog’s blue, ethereal spirit rise from her body. I’ve had Beings hike with me, transparent though they were. I’ve had a connection to the workings of the earth that have lifted me to a different plane. I believe we all have these magical moments, if we are willing to let go of our preconceived notions about how things work. Too often we say, “that can’t be” or “it’s just a figment of your imagination” and the magic that presented itself disappears. I hope my book helps people be more aware of the magical moments in their own lives and revel in their bigger world.
Tyler Baras is the Chief Science Officer and Co-Founder of Area 2 Farms. Tyler has a range of urban agricultural experience from homesteading to commercial hydroponics. While completing his B.S. in Horticultural Sciences at the University of Florida, he traveled overseas to study Organic Agriculture in Spain and Protected Agriculture (greenhouse production) in China. After graduation, he worked as a grower for 3 Boys Farm Inc., one of the first certified organic hydroponic farms in the United States. In 2013, Tyler moved to Denver, Colorado where he worked as the hydroponic farm manager at The GrowHaus.
Home Hydroponics: Small-space DIY growing systems for the kitchen, dining room, living room, bedroom, and bath” is my third book on hydroponic gardening. Most hydroponic gardens look like a maze of PVC pipes, including many hydroponic garden designs described in my previous books, but in my latest book I detail 14 different DIY hydroponic garden designs that heavily prioritize the aesthetics of the garden while maintaining their functionality.
The Captain’s Daughters is Doreen D. Berger’s first novel in a series about the adventures of the Marsh sisters, Diane and Robin. Doreen, known to her family and friends as Diane, has based the series on her relationship with her lifelong friend, Robin, and their spirited childhood escapades.
The Captain’s Daughters was inspired by my childhood escapades with my best friend Robin. We always seemed to find ourselves in hot water for a silly prank we pulled! We were both astronomy and science-fiction fans and dreamed about living on a starship. The book combines our not-so-good behavior with our dream of outer-space travel.
Peri Heft is a 360-degree health and wellness coach who educates, encourages, and inspires others to improve their Meals, Movement, and Mindset. As a certified nutritionist, yoga and fitness instructor, personal trainer, and lover of all things health and holistic wellness, her knowledge and experience surrounding food and its effect on the body plays a large role in her success as a leader, educator, trainer, and author. In her spare time, she enjoys cooking, working out, creating artwork, enjoying live music, exploring the outdoors, and spending time with friends and family.
I’ve always cooked meals and shared recipes, but as my social media accounts grew bigger and bigger, and as I started taking on more clients in the Health and Wellness industry, people just kept asking for my recipes. Anytime I would share a dish on, let’s say Instagram, I would get several comments and messages asking for the recipe. So I figured, why not create a book that I could sell to folks who want “in” on my cooking style, and provide one to my private clients too!?
Angela Thompson is a writer of children’s books. She holds a degree in Health and Human Services and has worked in this field for numerous years. Her books rhyme to hold the children’s attention while they are learning. She currently has two books on the market, Who Has Seen the Wind, Today? and How We Get From Here to There?
It is titled How We Get From Here to There? It’s a rhyming book about transportation. It is written in a humor mode and I wanted it to be fun to read, yet an easy way to learn about transportation. It was inspired by my grandson’s love of big trucks. He was so excited when saw them while traveling and he likes books about big trucks.
Sabina Khan, PhD
Dr. Sabina Khan, PhD, is a research scientist, clinical professor and freelance writer of brain health, nutrition and scientific articles in Miami, FL. Dr. Khan’s research falls at the intersection of neuroscience and women’s health and is focused on how our genetics, diet, environment and lifestyle shape the brain.
I have been working as a licensed clinician for nearly ten years and seeing the ins and outs of neurodegenerative conditions, working with patients with Alzheimer’s, Dementia, speaking with family members of patients suffering from cognitive deterioration, I was often asked about preventable factors. I wanted to dive into if living a healthier lifestyle, our diet and nutrition could really outweigh genetic predisposition and make a significant difference for individuals with these conditions or at-risk with respect to brain health. Time and time again, I have found brain chemistry is absolutely changed by food, pollutants and lifestyle choices. This lead to my research deeper into neuro-nutrition and inspired me to write “Feeding Your Brain” for those wanting to take control of their brain health.
Brad Richard is the Author of the book “Man at 50 – A Journey of Crisis, Revelation and Survival!” His speaking, mentoring and coaching is focused on helping people move forward with their lives through his unique system of going back to move forward! He currently lives in East Texas with his wife. He is a full time security officer, Realtor® and Host of the Podcast “Man at 50!” His goals are simple: help at least one person and leave his story behind for others to learn, benefit and grow by!
Man at 50 – A Journey of Crisis, Revelation and Survival is my Autobiography, my story of a life filled with fear, sexual identity questions and codependency. I lived a life of a child for the 1st 50 years of my life. My life changed dramatically after I decided my life had to change and the time had come for me to step up to Manhood!
Teresa Pérez is an American expat living in Argentina with her husband, two dogs, myriad cacti and assorted plants, and the errant wild birds that visit her two bird feeders on any given day. Oh yeah, and the daughter of Cuban immigrants.
My latest book is the second in a children’s book series. The idea behind the series is to get children (and their parents) interested in geography and other cultures through the adventures of a loveable, yet imperfect dog. The books blend facts about the country featured in each installation presented alongside a fictional storyline with interesting cultural tidbits scattered throughout. I typically highlight things that are less known or something one might not find in typical tourist literature to offer a more unpredictable adventure and engage both adults and children. I have purposely chosen places off the beaten track in each country, not the most famous cities, as touristy places can often have more outside influence and may not truly reflect the local culture. I also include things which link one country to another (in the series) to highlight the fact that we, as humans, have more in common than one might think, no matter how different our cultures may seem.
This second book was inspired by my time in Uganda working for an NGO. Having never visited the African continent before, I had no expectations but was utter overwhelmed at how friendly, curious and lovely Ugandans are. Everywhere I went, I found a kinship with the local people and shared stories and time with people which has left a lasting impact. When I tell people that the Ugandans are the friendliest people I have ever met in my travels, it always surprises them – for preconceived notions really, not based on any actual experience. Some of their traditions, perhaps “ways of thinking” is a better way to express it, are ideas that are simple but profound at the same time and, in my opinion, worth sharing. I truly wanted to impart this experience, especially with young people, who have not been influenced by the world yet. I firmly believe if children are curious at a young age, this will follow them throughout life and hopefully lead to a desire to learn more about the world around them and form opinions based on facts and experience and not just hearsay.
I have been traveling and living abroad for almost 20 years now. I have heard so many notions adults have about different countries without having ever travelled themselves. I was a bit taken aback by this realization and decided I wanted to do my small part in making a positive change, starting with young people. Adults often get caught up in the practical differences about countries – the language, access to services, level of development – and forget that there are people and cultures with long and wonderful traditions which are overlooked in the process. Children don’t have these notions yet and are more likely to engage in a story they like and become curious about where it is in the world; my sincere hope is that they then read more. When I was a kid, I received a “pen-pal” through a service and that contact with the world outside mine was enough to plant the seed of curiosity within me. With the world changing, not always in the best ways, finding commonalities in our fellow man around the world is something we need now more than ever. Hopefully, Joaquin’s adventures will inspire kids to look outside of themselves and their own cultures and find the good in the world that exists outside their realities.
Matt Ingwalson is an author of genre fiction including mysteries, thrillers and horror stories. He has published multiple books including SHELF UNBOUND’S BEST INDIE NOVEL OF 2015 and the award-winning Western noir Sin Walks Into the Desert.
The Baby Monitor: A Novella of Family Horrors is about how everyday life drives you insane. The bills that won’t stop coming. The alarm clock you forget to turn off on the weekends. The flat tires. The broken washers. Sometimes it almost seems like there’s some evil force tormenting you.
In The Baby Monitor: A Novella of Family Horrors, you meet Richard and Lissa, two young parents who can’t sleep. Every night their infant son wakes them up screaming, crying, gripped by a terror he’s too young to name. But does he simply have nightmares? Is his nursery haunted? Or there is something even darker eating away at the sanity of this new family? It’s a book about secrets, sleeplessness and stress.

domain: library


Bridging that special gap between pistol, machine pistol and assault rifle.
The submachine gun was born from the desire of warplanners to provide the basic infantryman with the voluminous firepower of a machine gun with the portability of a pistol in the early part of the 20th Century - the requirement proved most apparent during World War 1. The first useful submachine gun design was of German origin and became the Bergmann MP18. However, it would not be until World War 2 that the submachine gun would truly take the stage as a viable infantry weapon as its use was prevalent on all sides of the conflict. The war produced the reliable American M1 Thompson, the war-winning British STEN series and the famous German MP38/MP40 types. The Germans ushered in an all-new era of submachine gun design during the Cold War years with the introduction of the excellent Heckler & Koch MP5 which went on to be used by dozens of countries the world over.
There are a total of [ 127 ] Submachine Guns (SMG) entries in the Military Factory. Entries are listed below in alphanumeric order (1-to-Z). Flag images indicative of country of origin and not necessarily primary operator.
The "Military Factory" name and MilitaryFactory.com logo are registered ® U.S. trademarks protected by all applicable domestic and international intellectual property laws. All written content, illustrations, and photography are unique to this website (unless where indicated) and not for reuse/reproduction in any form. Material presented throughout this website is for historical and entertainment value only and should not to be construed as usable for hardware restoration, maintenance, or general operation. We do not sell any of the items showcased on this site. Please direct all other inquiries to militaryfactory AT gmail.com. No A.I. was used in the generation of this content; site is 100% curated by humans.


Looking for Best Mattress Elavator…
There are benefits to sleeping on a bed mattress made with natural latex. Luma incorporates latex in the construction of each of its bed mattress models. The business introduced in 2015, building on extensive research study to establish mattresses that assist enhance sleep quality.
The business has four bed mattress options: the flagship Luma, the Natural Latex Hybrid, The Hybrid Sleep System, and the Latex Slumber System. The Luma mattress, which we cover in this evaluation, is the brand name’s most economical alternative.
The Luma mattress is a latex hybrid that is offered in three firmness alternatives. The mattress has a natural latex convenience layer with filched coils for assistance. The Luma provides moderate contouring and top-notch pressure relief. Its breathable construction will likely interest hot sleepers.
Luma Sleep bed mattress appropriate for the majority of sleepers due to the brand’s vast array of composition, firmness, and density options. The swappable convenience layers also guarantee owners can change their bed’s firmness setting if they are disappointed with how it feels down the road.
Here are some of the key characteristics of the Luma Mattress:
- Personalized comfort: The Luma Mattress is available in three various firmness choices. Sleepers can exchange their Luma Mattress for a various firmness option at any time during the first year at no charge.
- Highly responsive: Premium Talalay latex is used in the production of the Luma Mattress. This product is extremely responsive to the shapes of the body, providing back, neck, and joint support.
- Breathable: Open-cell Talalay latex is all-natural and more breathable than memory foam. The Luma Mattress features aerated Talalay foam to additional increase air flow.
- 10-year guarantee: The Luma Mattress comes with a 10-year guarantee from the manufacturer. Luma will change the bed mattress or repair at no expense to the consumer if any problems are discovered in the mattress during this duration.
In addition, customers have actually identified some prospective weak points with the Luma Mattress:
- Not perfect for heavy sleepers: The Luma Mattress is topped with a convenience layer of 1.5″ of latex. This might not offer adequate assistance for sleepers who weigh over 200 pounds.
- Customer support issues: There have been some grievances that Luma’s customer service is inadequate. Some sleepers have actually had trouble with exchanges, returns, and repair work.
They likewise have longer-than-average anticipated lifespans and need to endure excessive drooping for at least six to seven years since the beds are made from resilient natural latex.
Other efficiency aspects differ by design. The hybrids offer fantastic temperature level neutrality due to their breathable covers and strong air circulation through the coil layers, while the Latex Rest System isolates movement transfer well and does not make any noise when bearing weight.
All four Luma Sleep designs have below-average price-points compared to other hybrid bed mattress. Free ground shipping is available to all consumers in the contiguous U.S.; additionally, the Rest System designs receive complimentary White Glove delivery. All Luma Sleep beds are backed by 100-night sleep trials; the Luma Mattress and Natural Latex Hybrid Bed mattress include 10-year service warranties, while the Sleep System designs include 15-year guarantees.
What Type of Sleeper is Best Suited to the Luma Sleep Mattress?
Based upon our customer feedback, Luma Sleep mattresses have received the list below grades among sleepers of various weights and chosen sleep positions.
Please keep in mind that these scores are subjective, which everyone has varying experiences on different bed mattress.
Sleeper convenience and spine support are the most essential factors when it pertains to picking a mattress.
A look at the Luma Mattress Best Mattress Elavator
The Luma Mattress is an 11″ hybrid mattress consisting of 3 layers.
- 1.5″ convenience layer: The top layer of the Luma mattress is 1.5″ of aerated Talalay latex. This layer supplies contour assistance for the back, neck, and joints, in addition to a comfortable surface area for sleeping.
- 8″ innerspring support layer: The bulk of the Luma Mattress is its innerspring coil core. Each spring is pocketed individually so regarding act individually from the others. This assists the mattress to form-fit to a sleeper’s body.
- 1″ base layer: An extra-dense layer of HD base foam makes up the base layer of the Luma Mattress. This serves as a protective structure for the innerspring coils as well as a responsive foam surface for support.
The Luma Mattress also comes with a mattress cover. It covers the bed mattress entirely and likewise acts as a mattress protector.
The Luma Mattress was created and is produced in the USA.
Luma Sleep costs and Guarantees
|Luma Mattress||Twin XL||$795||53|
|Luma Mattress||California King||$1195||105|
The Luma Mattress features a 100-night sleep trial. During this time, a sleeper can return the bed mattress for a full refund or exchange the bed mattress for another firmness option at no cost. After 100 days, consumers are no longer eligible for a refund, though they are still able to exchange their bed mattress for up to one year after purchase. There is a limitation to one mattress exchange.
In case of a return or exchange, Luma will send out a courier to pick up the mattress and they will have it delivered to a charity or a recycling center.
A 10-year warranty comes requirement with the Luma Mattress. This covers maker’s defects as well as some wear and tear that may happen gradually, like sagging, fractures in the foam, and broken zippers.
Luma uses a funding alternative to help clients spend for their mattress with time. The Luma Mattress can be spent for over six months time at 0% APR. Best Mattress Elavator


UHF Dual channel digital wireless microphone
The IU-2078 is for a new generation of Dual Channel digital wireless microphone, introduce in digital modulation and high performance audio ADC and DAC, with a low delay of the audio encoder to achieve a high fidelity audio transmission. Simple operation by infrared frequency synchronization, which can cover the frequency range UHF 500-980MHz (depend on the region), stable circuit characteristic, and audio carrier signal transmission is stable with visible range over 60 meters , encrypted transmission and decoding circuit avoid any interference fro outside. Highly cost-effective products provide more options in the field of wireless system.
1 ﹑ Using UHF band, PLL phase lock circuit, stable characteristics, low harmonic radiation.
2 ﹑ Digital modulation, 32 bit encryption
3 ﹑ Equipped with Antenna diversity technology
4 ﹑ Preset 2X200 selectable frequency
5 ﹑ Maximum transmission power 13dBm
6 ﹑ Maximum audio input 2Vpp, Maximum audio output 1Vpp
7 ﹑ Dual antenna diversity circuit
8﹑ 8-band equalizer processor
9﹑ Anti-Squeal noise circuit
10﹑ Low latency digital audio circuits (less than 3MS)
11﹑ Audio AGC limiting processing circuit.
12﹑ With a flat frequency response of 40Hz-18KHz response range.
ICM IU-2078 dual wireless microphone
- Brand: ICM
- Product Code: IU2078
- Availability: Contact for availability


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Dental health is simply too crucial that you just be left beyond conversations about medical reform. Many suppliers present remedies that broaden entry to consideration while defending the widespread accessibility and affordability of dental. A medical school might have a dental program or be able to present the names of some who dentists who are expert in Dental Sedation.
Though the laser is superior for some procedures, the drill still outperforms it for many others, taking this into consideration, and the cost of the laser unit being generally prohibitive, a dental laser costs between eight thousand and fifty thousand dollars in comparison with the outdated fashion pneumatic dental drill costing between two hundred and 5 hundred dollars.
Benefits of sound dental care practices.
Dental care permits you to preserve the whiteness, strength, and wonderful situation of your teeth. As well as, you’ll have the boldness to smile because of your amazingly stunning enamel that improve your physical appearance. Traditional Filling Methods Branding for my part means connecting a “mark”Â whether thats a logo, colours, photographs, identify with a set of certain expectations associated with the mark:Â great emotions and ideas about what they’ll get.
The implant work included X-rays elimination of the tooth, the deep clear, the submit, the momentary crown, moulds for each the temporary and permanent crowns, about 6 hours of dental appointments to this point, another deep clean, directions on care, and a permanent crown that has cubic zirconia by means of the center and can sparkle like the true deal. It won’t be porcelain coated steel that will present if my gums recede, which they shouldn’t with the form of care I’m going to get going forwards.
Dental care can even decrease tooth discoloration.
This company can also be aware of the challenges and pain that comes with oral issues. Its consultants are at all times dedicated to making sure that you get dependable and efficient companies. Today, many individuals depend on the companies of this firm for dependable and fast solutions. By way of this firm, additionally, you will get fast access to an intensive community that comprise of skilled and skilled dentists. Principally, this firm has at all times stored dental health and advantages reasonably priced by guaranteeing value-control providers and solutions.
If you have further questions about the new therapy or when it could be obtainable in your area, ask your dentist. Dentists wish to have the most recent technology in their offices, and will have the ability to reply your questions about cavity prevention. Still, for the future of more affordable dental care, this new coating seems to be a good way to forestall cavities.
The horrifying ordeal anyone with terrible cavities can by no means be that piercing if the correct therapy is only obtained. It’s important to choose the correct if toothbrushes and toothpastes for these younger ones. Not very way back, the mandible of a Mayan girl was found during an excavation.

domain: medical


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Document Type : Case Report
1 Trauma Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2 School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
3 Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
Objective: Necrotizing fasciitis of the perinea, referred to as Fournier’s gangrene, is a necrotizing infection of the perinea. To the best of our knowledge, there is no report on the Fournier’s gangrene following an ant bite and this is a rare case report of this type.
Case Presentation: In this rare case report we describe a 20-year-old man who developed Fournier’s gangrene following an ant bite which resulted in his death. He sustained numerous ant bites in the perinea. Subsequently, he suffered from itching of the area and had scratched the area frequently leading to dermal ulcers and laceration, pain, and swelling of the scrotal area followed by fever and diminished consciousness. Finally, he presented to the emergency room (ER) after 72 hours of ant bites with a shock. Physical examination revealed extensive necrosis of scrotum. The primary treatments including antibiotic therapy, normal saline solution, and dopamine were not effective.
Conclusion: Even a simple nonpoisonous insect bite can lead to Fournier’s gangrene and death. Paying greater attention to the site of bite, especially in the perinea which is anatomically more susceptible to infection, observing hygienic principles, and quick access to healthcare centers may prevent the patient’s death
2. Mahdizadeh F, Safari S. Concurrent hand and penile gangrene following prolonged warfarin use; a case report. Emerg (Tehran) 2017; 5(1): e71.
4. Sasannejad P, Rezaei F, Bidaki R, Zarepur E. Rare presentation of moyamoya disease with sub acute presentation in Iran. Iran J Child Neurol 2018; 12(1): 89- 93.
5. Yeniyol CO, Suelozgen T, Arslan M, Ayder AR. Fournier’s gangrene: experience with 25 patients and use of Fournier’s gangrene severity index score. Urology 2004; 64(2): 218-22.doi: 10.1016/j.urology.2004.03.049.
6. Korkut M, Içöz G, Dayangaç M, Akgün E, Yeniay L, Erdoğan O, et al. Outcome analysis in patients with
Fournier’s gangrene: report of 45 cases. Dis Colon Rectum 2003; 46(5): 649-52. doi: 10.1007/s10350-004-6626-x.
7. Singh G, Sinha SK, Adhikary S, Babu KS, Ray P, Khanna SK. Necrotising infections of soft tissues--a
clinical profile. Eur J Surg 2002; 168(6): 366-71. doi:10.1080/11024150260284897.
8. Aimoni C, Cilione AR, Grandi E, Lombardi L, Merlo R, Pastore A. Cervical necrotizing fasciitis. Eur Arch
Otorhinolaryngol 1999; 256(10): 510-3. doi: 10.1007/s004050050201.
9. Schmidt GA, Mandel J. Evaluation and management of severe sepsis and septic shock in adults.UpToDate; 2013.Available from: https://www.uptodate.com/contents/evaluation-and-management-of-suspected-sepsis-andseptic-shock-in-adults.
10. Imanian M, Ghasemzadeh MJ, Zarepur E, Zarepur A, Sarbandi Farahani R, Sarbandi Farahani R. The Relationship between Pneumonia with parental smoking in children under 10 years old: a case- control study. Int J Pediatr 2018;6(6): 7791-6. doi: 10.22038/ijp.2016.7801.
11. Unuigbe EI, Ikhidero J, Ogbemudia AO, Bafor A, Isah AO. Multiple digital gangrene arising from traditional therapy: a case report. West Afr J Med 2009; 28(6): 397-9.
12. Verma SB. Necrotizing fascitis induced by mosquito bite. J Eur Acad Dermatol Venereol 2003; 17(5): 591-3. doi:10.1046/j.1468-3083.2003.00819.x.
13. Poitelea C, Wearne MJ. Periocular necrotising fasciitis--a case report. Orbit 2005; 24(3): 215-7. doi:
14. Jones AE, Brown MD, Trzeciak S, Shapiro NI, Garrett JS, Heffner AC, et al. The effect of a quantitative resuscitation strategy on mortality in patients with sepsis: a metaanalysis. Crit Care Med 2008; 36(10): 2734-9. doi: 10.1097/CCM.0b013e318186f839.

domain: literature


On ThanksgivingDenise brings her girlfriend Michelle. From Wikipedia, the free encyclopedia. Demers Edit page. Melina Matsoukas.
Kudos to the makers. Acting was top- notch. Tessa Johnson 9 episodes, Cole Sand Barbara Sanderson 7 episodes, Clive Dundle 1 episode, Nurse Gwynne 1 episode,
John Legend performs as a featured guest. BBC News. Flanked at all times by her family, Eilish feels sturdy, if a bit jaded, in anticipation of the ways her life will continue to change in the coming months — harder questions, greater expectations, less privacy. September 3, Slate also noted other references on the show, where the plot and directorial choices of the episode "The Thief" in particular seems to be heavily influenced by Bicycle Thieves.
Pure, bold works distinguished by an innovative, forward-thinking approach to storytelling populate this program. Director and screenwriter: Miranda July, Producers: Dede Gardner, Jeremy Kleiner — Low-stakes grifters, Old Dolio and her parents invite a chipper young woman into their insular clan, only to have their entire world turned upside down.
As his disturbing livestream is absurdly embraced by the social media hellscape, a comedienne emerges as the only hope to stop this rampage. The Sundance Film Festival and other public programs connect audiences and artists to ignite new ideas, discover original voices, and build a community dedicated to independent storytelling.
Michael and I have a lot of these meetings because we have a lot of these scenes and, more often than not, the director is far more uncomfortable with the conversation than us.


Let The Right One In
The L Word: Generation Q
The Circus: Inside the Greatest Political Show on Earth
George & Tammy
The Lincoln Project
I Love That For You
All Access, Season 29, Episode 1: Episode 1 of the Emmy® winning series chronicles the buildup to one of the summer’s biggest bouts as superstar Gervonta Davis looks to become a three-division champ against unbeaten Mario Barrios.
Stream SHOWTIME series, movies, documentaries, sports and much more all on your favorite devices.


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19%: When Will Women Have the Floor?
The Harvard Women's Law Association is proud to host our 7th Annual Conference, 19%: When Will Women Have the Floor?, which will take place at Harvard Law School on Friday, February 8th, in Wasserstein Hall, Milstein East. The event is sponsored by Kirkland & Ellis, LLP.
The event will explore women's representation in politics and public life following an exhilarating election cycle and a historic year for women in elected office. We hope to provide a forum for our community to explore and critically examine what roles lawyers can play in pursuit of equal representation of women in the political process. We will also consider questions such as, do “more women” leaders equal more “pro-woman” policies? And what role can lawyers play in furthering women in the political sphere?
We are honored to welcome Stephanie Schriock, President of EMILY’s List, as the 2013 keynote speaker. Other highlights from the conference will include Fawzia Koofi, Afgan Parliamentarian and 2014 Presidential candidate, Susan Markham, Director of Women's Political Participation at the National Democratic Institute, Katie Biber, General Counsel of the 2012 Romney presidential Campaign, and Karen Dunn, debate preparation aid for President Obama and Communications Director for Senator Hillary Clinton.
For a full list of our 16 exciting panelists, more information about the conference, and registration, please visit: tinyurl.com/19percent

domain: sociology


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Chennai: The All India Anna Dravida Munnetra Kazagham (AIADMK) released its manifesto on Tuesday. Reading out the salient features of the manifesto, deputy Chief Minister O Panneerselvam said that his party would appeal to the President, Governor and the Central government for the release of Rajiv Gandhi assassination case convicts. (Also read: EC’s Notification on First of Seven-phase Polls)Also Read - AIADMK to Hold Executive Committee Meeting on Dec 1
He said while Amma national poverty alleviation scheme will be implemented, those below the poverty line, the differently abled and landless agricultural labourers would get a monthly aid of Rs 1,500. Also Read - Video: Sasikala Visits Jayalalithaa's Memorial For First Time Since Jail Release
The manifesto also talks about implementing the Cauvery Godavari river linkage scheme. Also Read - Tamil Nadu Assembly Passes Bill to Scrap NEET; Enables Admissions to MBBS/BDS Based on Class 12th Marks
Another area of focus for the AIADMK is education and the party said the portfolio, which is currently on the Concurrent List, would be brought under the State List. It also said it would urge the Centre to waive education loans and would take measures to ensure that the state was exempt from NEET exam.
The party said it would implement three water management schemes. Then, MGR national employment scheme will also be implemented in association with the Philippines.
Meanwhile, the DMK also released its manifesto. During its release, party chief M K Stalin read out important contents and promised that the seven convicts of Rajiv Gandhi assassination case will be released on humanitarian grounds.


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Soy Isoflavones and Phytoestrogens are the same type of thing. Phyto means plant, so phytoestrogens are plant based estrogens or estrogens from plants. Since soy is a bean from a plant...it's a phytoestrogen coming by way of soy isoflavones. You won't be getting any plant based estrogens from Promensil. From what I understand, it's a chemical based estrogen. You can ask your pharmacist to be sure.
We do carry a Mega Soy product from Life Extension, but it's $20.00 for 60 caps. Twice the price. Twinlab is also a good product, so if you can get it that inexpensive...go for it.
|What is the concentration of progesterone in the 2 ounces of viva la creme? Specifically, in the 60cc how many milligrams of progesterone? Thanks
There is 500mg of progesterone per ounce. So in the 1.96 oz of "Viva La Creme" progesterone cream, there is a total of approx. 1000 mg of US progesterone. Hope this information helps.

domain: chemistry


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“Now therefore be it resolved that I, Byron W. Brown, Mayor of the City of Buffalo, do hereby proclaim May 8-13, 2017 as Economic Development Week.”
On Monday, May 8 Buffalo Mayor Byron Brown announced a proclamation for Economic Development Week. Mayor Brown paired the announcement with the debut of two marketing videos for the City, made in conjunction with yours truly, Invest Buffalo Niagara. Watch them here:
Busy, busy Buffalo
The City of Buffalo has seen a well-documented rebirth over the last handful of years. The tide has turned and national attention has been given. In the Mayor’s Office of Strategic Planning, that is well known. Director of development Becky Gandour, economic development coordinator Tuona Batchelor, and Royce Woods, commercial real estate analyst don’t always get the spotlight, but they’re always deserving. Their fingerprints are on almost all of the major projects that come to mind when you image the new Buffalo.
“No day starts the same, and no day ends the same,” said Woods.
Pulling on the same end of the rope
In the City of Buffalo, collaboration is key. There are many organizations working to pull the City up. They’ve been able to see success because they’ve figured out ways in which to work together and pull on the same side of the rope. Partnerships on the state, county, and city level are to thank for much of the revitalization everyone is so excited about.
Buffalo is Bak
The City’s revitalization could not have happened without successful economic development projects and the businesses behind them. BakUSA, a win of ours, has been a poster child for this ascension.
They create tablets for specialized industries and do so right on Michigan Avenue. The founders were originally inspired after the earthquake in Haiti in 2010, creating accessible technology and hiring women that were struck by tragedy or weren’t given a fair shake in the economy. It was a non-profit company.
When they decided on a U.S. business-plan, they looked right at Buffalo. Why? The people. They cite the City of Good Neighbors mantra that we’ve all grown up representing. As a manufacturing company, they see opportunity in the skillset in this talented city. Buffalo has both the old-school manufacturing workforce and the new technology focused engineers. They hire people left out of the new economy, often retraining previous manufacturing employees for new tablet creation. They also focus on hiring immigrants, refugees, and diverse individuals. Upon opening in January 2016, they had about 15 employees. Today, they’re up to 86 and growing. They were also able to get beginning logistics taken care of in the Start-Up NY program, hiring over 20 University at Buffalo graduates.
Photos by Sarah Larson and Casi Hall