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[DRUG DOWNER] Less is more when it comes to antidepressant prescribing, use
Doctors should prescribe fewer antidepressants and for shorter periods of time, because of the ongoing uncertainties about their effectiveness and the potential severity and durability of both side effects and withdrawal symptoms, a new review article suggests.
According to the latest data from the US Centers for Disease Control and Prevention, 13.2% of adults used antidepressants in the past 30 days and the percentage of use increased with age, from 7.9% among adults aged 18–39 to 14.4% for those aged 40–59 to 19% (one in five) for those ages 60 and over.
While there might be a role for antidepressants among patients with severe depression, the cons may outweigh the pros in those with mild-to-moderate depression or in those whose symptoms don't yet qualify as depression, the review authors say. Much of the evidence for the effectiveness of antidepressants comes from placebo-controlled trials lasting just 6–12 weeks, and the results don't meet the threshold for a clinically important difference, say the authors. Overall, the review found no clinically relevant difference between these drugs and placebo on depression.
Side effects are also common. Around one in five patients on newer antidepressants, such as selective serotonin reuptake inhibitors, report daytime sleepiness, dry mouth, profuse sweating, or weight gain; at least one in four report sexual difficulties; and about one in 10 report restlessness, muscle spasms or twitching, nausea, constipation, diarrhea or dizziness.
The prevalence of side effects may be even higher among those taking antidepressants for more than three years, and can include emotional numbness and mental "fogginess."
Gradual dose tapering may best help people stop these medications; however, very low doses may not be commercially available. Long-term users may need additional help to support deprescribing, so it's better not to prescribe or use these medications in the first place unless non-drug solutions are ineffective and depression is severe.
To read the full article, published in Drug and Therapeutics Bulletin, click here
For CDC information on antidepressant use, click here
Do you have news to share?
The ICAA welcomes your news submissions. Please send your press releases to firstname.lastname@example.org ICAA's email for submissions-and staff will consider your news for possible publication. Newsworthy topics include such things as center/community openings; initiative or campaign launches; announcements of awards, promotions or grants; and other topics of interest to active-aging professionals.


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Typography has a unique place in art and graphic design. Some pieces use typography to add context to a piece, to contrast with the rest of the artwork in a piece, or to help drive the point of a piece. No matter what the reason typography is an element to utilize. In this project I had to showcase how typography and a typographic layout can invoke a specific emotion.
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domain: artistic


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A video has surfaced online showing the moment Police officials in the UK were invited to calm a situation between members of a white garment church.
The incident had to do with stolen funds in the church.
As the police officers led away some members of the church, other members are heard taunting them in Yoruba and calling them thieves.
"Ole. Funmi, ole," members are heard saying as some members are ushered out of the church compound.
Watch The Video Below;

domain: law


You may have a friend, who knows someone that says it’s a good idea to do something you might not think with your AC. Although it may seem like a good idea at first it may actually end up costing you more energy or even money in the end. Below we have listed the top five myths about how to go about using your machine and what to avoid for maximum efficiency.
Myth #1: It’s more efficient to leave your portable AC running at a high temperature when you’re not around then it is to turn it off.
That statement is actually false. First off, turning up your AC to a higher temperature while you’re gone will waste energy. Setting your timer for half an hour to an hour before you come home is actually a better idea. It’s always nicer to come home to a place that has been cold for a while, but rather than waste electricity and potentially shorten the life of your machine why not take advantage of its timer? Leaving your unit on essentially causes your compressor to cycle on and off many times just to keep that temperature constant. Leaving it off for extended periods is actually best for your machine.
Myth #2: Your portable AC will perform at its best no matter where you place it or install it.
This statement is also false. Where you place your unit can have a large effect of how efficiently it works within your space. Setting it in direct sunlight will cause your machine to overwork and use more energy. The same goes for placing it close to large electronics that give off heat as well. It’s best to place your unit directly under your window or at least somewhere shaded away from any large electronics.
Myth #3: Maintaining and changing your filter once a month is too often and not necessary.
It all comes down to how often you use your unit. If you use it once or twice a week I don’t see a reason to change your filter once a month. Although, if you use your unit daily. Then doing so may be a good idea. Once your filter starts looking brown and Dusty you should definitely consider making a change very soon. Something as little as a dirty filter can cause your machine to work that much harder and cost you just that little bit more on your utility bill at the end of the month.
Myth #4: “Energy efficient/eco-friendly” are the best portable air conditioner units to buy and will automatically lower my utility bills.
Buying a unit that is energy-efficient will help you save money on your electricity bill at the end of the month but you still need to ensure that it’s installed correctly and securely.( see our article on How to get the best performance from your portable ac. ) At the end of the day you still need to make sure that you buy the best unit for your rooms dimensions. That is the first step on the path of making sure you are reducing any chance of a higher electricity bill at the end of the month.
Myth #5: Turning my thermostat down to an extremely low temperature will help cool my room faster.
In actuality lowering your thermostat to an extremely low temperature too fast will increase humidity. (especially if you live in a humid climate). It’s best to gradually lower the temperature so your unit doesn’t have to work too hard to maintain the temperature on the thermostat. In the end, portable AC units produce heat almost as much as they produce cold. So trying to make it cool too fast will cause it to overwork and to use more energy.
Click here to see our Whynter ARC-14SH 14,000 BTU Dual Hose Portable AC with Heater Review


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Discover the Ways of the Spirits And Master the Art of Command and Influence
Profound spiritual insights and powers await beyond the material world. In The Witch's Book of Spirits , Devin Hunter invites you to perform rituals and magic with spirit guides, familiars, angels, the deceased, faeries, and demons. Develop and enhance your relationships to your allies in spirit through soul flight, mediumship, and conjuration. Explore the inner workings of the Witch's Tree as well as the planes and peoples who dwell in its many layers. Expand the scope of your magic with the 33 Spirits, a system transmitted to the author by a special priesthood of spirits, his familiar, Malach, and the goddess Hecate. Working with spirits is the cornerstone of the witch's art. This book shows you how to stay in control as you increase your witch power and deepen your connection to forces seen and unseen.
"Devin covers in depth an elusive side of witchcraft that few have explored in great practical detail...Devin presents the material in a very grounded, no-nonsense approach paired with an inherent sense of responsibility. His understanding of mediumship, conjuring, flying, and working with the spirit world displays the truth that he not only talks the talk, but also walks the walk."Laura Tempest Zakroff, author of Sigil Witchery
"The Witch's Book of Spirits is the most complete book on working with the dead ever written for Witches, but it's more than a manual for communicating with souls of the departed. It's also a guide to the worlds which generally lay just outside of our grasp and a thorough look at the beings that live there. I'd also like to add that it's just a damn fine book about witchcraft, filled with advice and some much-needed common sense."Jason Mankey, author of The Witch's Book of Shadows
"Teaching an art requires a delicate brew of guidance, cautions, and encouragement; Devin Hunter's book hits the right recipe. The Witch's Book of Spirits is a book that captures the author's personal vision and process while providing systems and frameworks that can serve the reader in developing their own way with the spirits."Ivo Dominguez, Jr., author of Practical Astrology for Witches and Pagans
"In this book Devin gives not just the rituals necessary to conjure and communicate with spirits, but the tools for building life with them. He uses a method of teaching that alternates between supplying theory and principals that can be applied by almost anyone, with very specific rituals that he has received from the spirits himself. The result is a text that you will return to over and over again whether you are working his rites or developing your own."Jason Miller, author of The Sorcerer's Secrets
|Publisher:||Llewellyn Worldwide, LTD.|
|Product dimensions:||5.90(w) x 8.90(h) x 0.80(d)|
About the Author
Devin Hunter is a professional psychic medium and modern witch and is the resident house medium at the Mystic Dream in Walnut Creek, California. He holds third-degree initiations in both the Northern Star Tradition of Wicca as well as the Dianic Tradition of Witchcraft (the Cult of Diana), and is the founder of his own tradition, Sacred Fires . His AV Club–favorited podcast, The Modern Witch , has helped thousands of people from all over the world discover and develop their magical abilities. He is a blogger for Witches & Pagans and publisher of the magazine Modern Witch . Devin is currently teaching with the Black Rose School of Witchcraft and is the reigning Master of Ceremonies at the New Orleans Witches' Ball. Devin lives in the San Francisco Bay Area.
Table of Contents
Contents Dedication and Acknowledgments xv Foreword xvii Introduction 1 Part One: The Familiar Craft 5 Chapter One: Witches, Spirits, and the Familiar Craft 9 Mediumship 10 Flying 11 Conjuration 11 The World Tree and the Realms of Spirit 12 The Witch’s Tree 17 The Planes and Their People 19 Chapter Two: Staying on Top 21 How to Be in Control of the Spirit Worlds 22 Setting Contracts 25 Keeping Yourself Safe 26 Holy Flame Protection Exercise 29 The Fire Blessing of Hecate 30 Chapter Three: The Art of Mediumship 33 Being the Medium 38 Main Objectives of a Medium 41 Discernment 43 Practice and Procedure 45 Opening the Gates of Heka 47 First Contact 48 Profiling Spirits as a Medium 51 Tools to Aid Mediumship 52 Chapter Four: Spirit Guides and Familiars 61 The Symbiotic Relationship 63 Preparing to Meet Your Spirit Guide 70 Meeting Spirit Guides 73 The Spirit Guide Profiler 75 Chapter Five: Preparing for Takeoff 81 It’s All in Your Head 83 Preparing for Flight 85 The Cleansing Rite for the Home 87 The White Bath 89 Preparing the Room 91 Enhancing the Flight 92 Chapter Six: The Art of Flying 101 Activating the Etheric Body 102 The Flight Deck 106 The White Room 108 Flying to Another Plane 109 The Etheric and Subetheric Planes 111 The Spiritual Plane 112 The Plutonian Plane 113 The Angelic Plane 116 The Unhallowed Plane 118 The Divine and Chaos Planes 121 The Void and Omega Planes 121 Faery 122 Sabbat 125 Chapter Seven: Conjuration at a Glance 127 The Tools of Conjuration 130 Other Tools We Might Work With for Conjuration 136 Correspondences 138 Preparing for Conjuration 139 The Compass and the Witch’s Tree 141 Chapter Eight: Conjuration in Three Parts 145 The Three Stages of Conjuration 148 Summoning 149 Possession 151 Exorcism 154 Putting Them Together 159 Chapter Nine: The Keys of Hecate 161 The First Key: The Trident of Hecate 163 The Second Key: The Path of Hecate 165 The Third Key: The Helm of Hecate 167 The Fourth Key: The Pillars of Hecate 170 The Fifth Key: The Pentacle of Hecate 173 The Sixth Key: The Seal of Hecate 177 The Seventh Key: The Gate of Hecate 179 The Eighth Key: The Forge of Hecate 181 The Ninth Key: The Throne of Hecate 183 Part Two: The Spirits of the Familiar Craft 187 Chapter Ten: Angels 189 What Are Angels? 191 Why Work with Angels? 194 Where Are Angels Most Likely to Be Found? 195 The Angels of Enoch 196 A More Natural Form of Angelic Magic 199 Angelic Correspondences 200 Chapter Eleven: The Dead 201 The Afterlife 202 Ghosts and Hauntings 203 The Three Most Common Types of Preternatural Phenomenon 204 Other Types of Spirit Activity 208 Ancestors (The Not-So-Spooky Dead People) 210 Why Work With the Dead? 212 Working With the Dead 213 Correspondences of the Dead 215 Chapter Twelve: Faeries 217 What Exactly Are Faeries? 219 The Goddess of Faeries 223 Classifications of Faeries 224 Fae Correspondences 231 Chapter Thirteen: Demons 233 What Are Demons? 235 Why Work With Demons? 240 Where Are Demons Most Likely to Be Found? 241 How Do Demons Communicate? 242 Demonic Order 243 Solomon’s Demons 244 A Different Type of Demonic Magic 247 Demonic Correspondences 248 Part Three: The Grimoire of 33 Spirits, or the Book of the VEXNA-KARI 249 Chapter Fourteen: The VEXNA-KARI 253 VEXNA-KARA 255 VEXNA-KARO 256 VEXNA-KARU 257 The Nephilim Fire 258 The Rite of Treatise 260 Chapter Fifteen: The Others 263 The Spirits Above 264 The Spirits Around 276 The Spirits Below 285 Conclusion 295 Appendix a: additional sigils of the art 297 Bibliography and recommended reading 299 Index 303

domain: literature


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E! News first reported Carpenter's pregnancy after the actress' growing baby bump was spotted in Los Angeles during a coffee run on Saturday.
Carpenter and Avett, one of the members of the band The Avett Brothers, have been dating for nearly two years. Carpenter was previously married to her Dexter co-star Michael C. Hall, but the couple divorced in 2011.
TODAY'S VIDEO: Can the Sleepy Hollow stars guess the headless celeb?

domain: entertainment


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We don’t know about you guys, but every time we see the trailer for Nimrod Antal’s Predators, we become a little more excited. The intergallactic hunters really need a homerun to wash away the vapid memories of AVP, and this flick looks like it could do the trick!
Sideshow Collectibles recently unveiled its life-sized prop replica helmet from the Robert Rodriguez produced film simply titled “Mr. Black Mask” as played in the movie by Brian Steele, who just officially launched his new website. Dig on it below!
“Predators, a bold new chapter in the Predator universe, shot under the creative auspices of Robert Rodriguez, stars Adrien Brody as a mercenary who reluctantly leads a group of elite warriors who come to realize they’ve been brought together on an alien planet… as prey. With the notable exception of a disgraced physician, they are all cold-blooded killers – mercenaries, Yakuza, convicts, death squad members – human “predators” that are now being systematically hunted and eliminated by a new breed of alien Predators.”
Got news? Click here to submit it!
The hunt is on in the Dread Central forums!


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Jullian Gomes is a young man that has made a big name for himself in the South African house music scene, with his incredible production, namely his latest album with UK heavyweight AtJazz, as well as for his abilities behind the decks. Touring all over SA and Europe over the past few years, this young man has surely cemented himself as one of our very best exports. The best part about all this, is that he is and will always stay, the humble, kind man he is!!! Jillian took time out of his busy schedule recently to record a very sexy deep podcast for the Trio Nova Sessions, as well as to answer a few of our questions. We hope that you enjoy!!!
Who is Jullian Gomes??
“Jullian Gomes, Portuguese Blood, South African Soul. Born and raised in Pretoria. Started Dj’ing and collecting Records back in 2003. Been into music since the very first time i heard it.”
You have been in the industry for quite some time now….what have been some of the challenges in the house scene over the years?
“I guess the ”lost in translation” regarding what real house music is. I think a couple of people have a wrong perception of what House Music is or what its about. For a lot of people its become more of a competition for who’s the best or who charges the Highest fee’s. The truth is it starts with Art and thats the only thing that really matters to me.”
You have had a pretty busy 2014… What were some of your favourite moments from last year?
What are your thoughts of our local music scene, especially the house scene and how it grew in 2014?
“The scene is healthy but i do think that it’s going more underground these days and its kinda disappearing from being as big as it was in terms of hearing it on the radio or every 2nd car that drove passed. I think a lot of the youth these days have moved over to the local Hip Hop scene and House is being seen as taking the back seat. No matter where it go’s underground or on national radio the scene is big enough for everyone, We just need to keep it alive and pass it on.”
2014 saw some amazing new artists hit the scene, anyone that you think needs a special mention?
You are playing at the Trio Nova SUNSET SIZLA party and on the Cabin Fever Dance Floor at Park Acoustics at the end of this month. Are you excited for these show and what can we expect from the show?
Where can we follow you on social media?
CATCH JULLIAN GOMES AT:
Trio Nova presents: SUNSET SIZLA – 28th Feb
Park Acoustics – Cabin Fever Dance Floor – 1st March


text: The alpha-2-adrenoceptor antagonist (3H)-rauwolscine has been used to label adrenoreptors in membranes from human cerebral cortex. The radioligand binds with high affinity (KD 2.08 nM) to a single population of sites with a density of 135 fmoles/mg protein. Adrenoceptor antagonists displaced binding in a simple monomolecular fashion with an order of affinity rauwolscine > yohimbine > phentolamine > corynanthine > prazosin indicating binding to alpha-2-adrenoceptors. Agonists displaced with an order of affinity clonidine > (-) adrenaline > (-) noradrenaline > dopamine > (-) isoprenaline but all displayed apparent Hill coefficients less than unity indicating heterogeneity of binding. The relatively high affinity of the alpha-1 antagonist prazosin for (3H)-rauwolscine binding sites in rat cerebral cortex was not observed in the human tissue which had pharmacological properties similar to those described previously in human platelet.

domain: chemistry


Have a brand new Mopar ring and pinion 3.55 gear that has never been out of the box. It is the 3/8" bolt hole size which fits 96-2000GTS and 97-2000 RT/10. Dealer just sent the wrong bolt hole size and it showed being the last one in the system. It is just the ring and pinion only, $375 and I will throw in shipping. List is $445. Would rather help someone out than bother with the hassle of shipping it back.


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I was at Mom's for Christmas and was surprised I found her knitting basket in the bathroom closet. She told me she could no longer handle it because of her arthritis. So she gave it all to me! What was inside was some yarn, one skein of Caron Simply Soft in the wine country colorway, two skeins of Red Heart Super Saver in the light blue colorway and two in gold. Two balls of Lion Brand Fun Fur, one of which was red with no label, the other was labeled lavender. She had printed a pattern for the Double the Fun scarf calling for these skeins, so I will try to make it for her.
Also in this knitting basket were several 1960s era books and patterns. It is so interesting to see the prices and store names 50 some years later. Stores like Woolworth and Woolco, pattern books by Coats & Clark, American Thread and McCall's, 35 page booklets for 35 cents. Time marches on, and although the colors used are from the 1960s and 1970s, the pattern itself is classic. Use today's colors and you still have a gorgeous item.
She also gave me several sets of straight knitting needles, both long and short, with a felt needle case, cable and stitch holders, crochet hooks, pattern reading metal board, point protectors, everything you need to get started. YouTube is my friend. There are tons of videos showing techniques and stitches. I did do a bit of practicing before I left up there. Feeling very awkward and uncertain with my swatch. Mom said it "looked OK, you just need to practice". I may try some dishcloths for short, instant gratification, learning pieces. Any first project suggestions?

domain: design


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Admirers of this blog know that animated films don’t really do it for me. This has nothing to do with how good or bad the movie is, I just have trouble identifying with cartoon characters. That said, Pixar knows how to keep a non-fan very interested. They released Up last year, which was a phenomenon, and now, a new Toy Story, the original of which ain’t half bad either.
All your favorite toys are back: Woody, Buzz, Mr. Potato Head, and so on. But now their loyal owner Andy is all grown up and soon headed off to college. His mom gives him three options: attic, donate, or trash. Unable to fully part with his toys, he opts for attic, but momma accidently sends them to a day care center instead.
The center soon turns disastrous as little toddlers rip and pull and prod at the old toys. The appointed leader of the day care, a fizzy bear named Latso, won’t let them leave. What soon unfolds is an entertaining, complex prison escape-type movie.
Look, I have only one criterion for critiquing an animated film: Can the adults enjoy it too? You know the kids are going to love it, but will you be able to sit through it without wanting to beat your head into the ground. Most adults will appreciate the voices of Tom Hanks, Tim Allen, Ned Beatty and, my personal favorite, Michael Keaton (who is clearly having a blast as a Ken doll). You’ll also enjoy the fact that the movie doesn’t treat you like an idiot. Thank writer Michael Arndt (who won an Oscar four years ago for his Little Miss Sunshine screenplay) and director Lee Unkrich (Finding Nemo, Monster’s Inc.).
Much like Up, the geniuses at Pixar know how to convey real human emotion, the best of which in this film takes place during a wordless scene where each toy slowly descends into a fiery blaze. I don’t want to reveal what happens, but, if only for a moment, I believed. B+
Note: Toy Story 3 is preceded by a remarkable sort called Day & Night, which basically puts two animated creatures against a black background, displaying the daytime off one creature and nighttime off another. It’s difficult to put into words, but believe me, it alone is worth the price of admission.


In the Miller Mood songs Product Information
In the Miller Mood album for sale by Ray Anthony was released Apr 16, 1995 on the Aero Space label. Recorded at the Bakery Studio, Hollywood, California in 1992. In the Miller Mood songs Includes liner notes by Ray Anthony. Ray Anthony Orchestra: Ray Anthony (leader); Don Simpson (arranger); Barry Zweig (guitar); Sal Lozano (clarinet); Lee Callet (alto saxophone); Roger Neumann, Bob Hardaway (tenor saxophone); Leo Anthony (baritone saxophone); Rick Baptist, Hal Espinosa, Dan Bryan, Jack Laubach (trumpet); Alan Kaplan, Bill Tole, Bob Payne, Morris Repass (trombone); Tom Ranier (piano); Kirk Smith (acoustic bass); Gregg Field (drums). In the Miller Mood CD music contains a single disc with 14 songs. ...See Full Description
In the Miller Mood album for sale Product Description
Ray Anthony - In the Miller Mood Album Track Listing
|4||Up a Lazy River|
|Additional Track Information In the Miller Mood buy CD music|
|5||To Each His Own See All 3||2:49|| $0.99||(Available)|
|8||Blue Velvet See All 2|
|Additional Track Information In the Miller Mood songs|
|10||Through The Eyes Of Love|
|11||Somewhere Out There|
|12||Day By Day See All 3 ||2:34|| $0.99||(Available)|
|Additional Track Information In the Miller Mood album for sale|
|13||Columbia the Gem of the Ocean See All 2|
|14||Sunset Serenade See All 2|
In the Miller Mood buy CD music Customer Reviews
||Best dance music|
This is beautiful dance, or meditation, music. Nothing spectacular, just nice music and of course trumpet leads that I love.
By helenalamont (Lake Havassu City, Arizona)
||Ray Anthony Band Leader|
Spectacular Music & Fantastic Service.
By gus001 (Grand Rapids Michigan)
||Excellent and a must|
Selections and sound quality outstanding,... this is a goodie.
By andy (Chiefland, Fl USA)
heard this album?
In the Miller Mood songs Product Details
|CD Universe Part number||1045073|
|Release Date||Apr 16, 1995|
|Recording Time||43 minutes|


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On exhibit: September 3 - October 15, 2016
Artist reception: Saturday, September 3, 4-7pm
Victor Perez makes work that explores notions of paradise and their relationship to commerce.
This show features paintings laden with lurid colors, and patterns that make reference to Geometric Abstraction and hard edge painting. Although playful and formalistic, Perez’s work looks at the influence of commerce on one’s sense of place. He is fascinated by signage’s ability to not only flatten a location into graphic elements but its influence over expectation and memory. Familiar forms arise and demand our attention loudly. Perez often subverts these forms with additions of contrived imperfections that suggest instability in these structures. While the physicality of the work blurs the boundary between image and object, its severity is softened by its pairing with domestic materials. This pairing elicits a desire to play with the familiar, possibly bringing our perceptions into question, hence the show’s title Funhouse.
Perez received his BFA from the University of Florida. He is the recipient of an honorable mention in Dave Bown Projects Semi-Annual Juried Competition and has been selected for an artist residency at the Atlantic Center for the Arts. He lives and works in Gainesville, FL.
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Antimicrobial Activity of SnO2 Nanoparticles against Escherichia Coli and Staphylococcus Aureus and Conventional Antibiotics
The prepared SnO2nanoparticles solution sample was employed for the inactivation of Gram-negative Escherichia coli (ATCC 25922) and Gram-positive Staphylococcus Aureus (ATCC 29213). The antibacterial activity of the synthesized SnO2 nanoparticles was evaluated using zone inhibition method. Antibacterial sensitivity of SnO2 nanoparticles in different dilution and conventional antibiotics were tested. 5 and 10 times of SnO2 nanoparticles solution shows strong inhibitory zone against E-coli and S. Aureus than conventional antibiotics Gentamycin and Nalidixic acid. Nalidixic acid gives no inhibitory zone against E-coli. The results showed that diameters of inhibited zones of different concentration SnO2 nanoparticles against Staphylococcus Aureus presented good antibacterial performance than Escherichia coli. As the amount of the nanoparticles in the solution decreases, antibacterial activity decreases.SnO2 nanoparticles show almost equivalent sensitivity like the conventional Gentamycin antibiotics and Nalidixic Acid antibiotic shows no resistance in E. Coli. SnO2 nanoparticles show more sensitivity than the conventional Gentamycin and Nalidixic Acid antibiotics in S. Aureus.
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Spiced Drinking Chocolate Kit
Immerse yourself in an exploration of flavour with this specially curated chocolate and spice kit, as you create 5 hot chocolates with their unique flavours reflecting regions from around the world - the ultimate treat for hot chocolate lovers everywhere.
Veganuary is here!
Try our limited edition Lemon Dark Chocolate Bar to celebrate...
We are proud of our British heritage – so we’re 100% committed to using UK suppliers for all our packaging, and hand-making all of our products in the UK.
We take our role in caring for our planet seriously. Ensuring that our chocolate is made from sustainably grown cocoa, and the ingredients we use are completely free from palm oil.
We work with global and local organisations to provide a safe and nurturing work environment that encourages life skills, offers emotional support, and helps build confidence.
Signature Collection Chocolate Bars
Single Origin Chocolate Bar Collection
Passionate about creating delicious handmade chocolates, our artisan range of beautiful chocolate gifts are created using our bespoke recipes with the finest of sustainable sourced cocoa and natural ingredients. We pride ourselves on the fact we do not use any preservatives and our chocolate is free from Palm oil.
Founded by Linda in 2006, a mother of two daughters who both had a milk intolerance when young. Choc Affair strives to create chocolate with ethical values at heart. We contribute financially to a project called The Chocolate Dream, supporting initiatives within cocoa growing communities in Colombia, from where our Single Origin Collection of chocolate is sourced.

domain: food


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Food Distributors: A Directory of Top Companies
Food distributors play a key role in the food and beverage industry, serving as the intermediary between the manufacturer and their respective retail, restaurant, and foodservice operator customers. Because of their longstanding relationships across the industry, partnering with the right food distributors can often make or break whether a potential buyer will stock a manufacturer’s product line. The following list excerpt is from Handshake’s 2016 Distributor Directory, a cross-industry resource that includes 54 top food and beverage distributors in the United States. Download the directory here.
Top Food Distributors
About: Cheney Brothers is a leading food distributor serving the Southeastern United States and the world.
Headquarters: Riviera Beach, FL
Brands: Duck Deli, Perdue, Kraft Foods
Cooper-Booth Wholesale Co.
About: Cooper-Booth Wholesale is a full-service convenience store distributor ordering grocery, food service, candy, and tobacco items.
Headquarters: Mountville, PA
Brands: Marlboro, Slim Jim, Jif Peanut Butter
Food Services of America
About: Food Services of America is a privately-held, family-owned broadline foodservice distributor.
Headquarters: Scottsdale, AZ
Regions: Mid-West, West, Alaska
Brands: Hidden Bay, Columbia Valley Farms, Heartland Baking Company
Labatt Food Service
About: Labbatt Food Service is the tenth largest foodservice distributor in the nation.
Headquarters: San Antonio, TX
Brands: Tyson, Kellogg’s, Dole
Performance Food Group
About: Performance Food Group is a distributor of over 150,000 food and related products.
Headquarters: Richmond, VA
Brands: Pepsi, Lay’s, Planters
About: Porky Products is one of the largest independent meat and seafood distributors in the country, distributing over one million products per day to over 1,500 independent supermarkets along the East Coast.
Headquarters: Carteret, NJ
Brands: Arctic Blue, Zandra’s, EJ Farms
About: Shamrock Foods is a nationally-ranked foodservice distributor.
Headquarters: Phoenix, AZ
Brands: Aspen Gold, Copper Valley, Ridgeline
About: Sysco is the global leader in distributing food products to restaurants, healthcare, and educational, and hospitality locations.
Headquarters: Houston, TX
Brands: Portico Seafood, Arrezzio, Wholesome Farms
About: Reinhart Foodservice is a distributor serving restaurants, healthcare, education, and hospitality customers across the country.
Headquarters: Rosemont, Illinois
Brands: Eagle Ridge, Bountiful Harvest, Cobblestreet Market
About: US Foods is a leading foodservice distributor that supplies national brands ranging from fresh meats and produce to prepackaged and frozen foods.
Headquarters: Rosemont, IL
Brands: Monarch, del Pasado, Glenview Farms
For the full list of over 50 top food and beverage distributors, download the 2016 Distributor Directory. Have experience with any of the distributors listed above? Let us know in the comments. For more resources related to Food & Beverage distribution, check out these links: White Paper: Solving Just-In-Time Inventory Challenges in Food DistributionOn-Demand Webinar: Replacing Outdated B2B Commerce Technology in Food & Beverage Distribution


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Jia Ali is a former model and actress in the Pakistani drama and film industry. He started his acting career with Muammar Rana in the movie Deewane Tere Pyar Ki. He is best known for his roles in the popular dramas Band Khairkin, Hum Tehre Ganhagar, Pukar, and Mir Abro. She also appeared in blockbuster movies Ghar Kab Aao Gay, Love Mein Ghum, and Saya e Khuda e Zuljalal.
As photos of her marriage were shared on various social media forums, people started criticizing her for marrying a businessman. People thought she was married to a businessman because of her money and financial status.


March 1, 2013|
March 2013's selection of notable quotes
February 25, 2013|
Officials in the most populous nation on Earth have finally owned up to clusters of the disease around areas beset by industrial waste and other pollutants.
February 8, 2013|
Scientists have identified the sticky substance that is damaging the feathers of hundreds seabirds washed ashore in England as an additive for lubricant oils.
January 29, 2013|
Satellite images reveal that small oil spills in the Gulf of Mexico are often larger than reported.
January 28, 2013|
The heat emanating from large metropolitan areas may be changing weather patterns thousands of miles away.
December 12, 2012|
In the wake of Hurricane Sandy, climate scientists should make their consensus about climate change known to all who care to listen.
November 20, 2012|
Homing pigeons and tree swallows are being used to monitor pollution in cities and track environmental clean-up work at former industrial sites.
October 1, 2012|
A look at what the President achieved during his first term in the areas of health, space science, energy, environment, and science education
September 19, 2012|
A former head of the Environmental Protection Agency, and one of the early forces behind the Clean Air Act, dies at 92.
September 4, 2012|
Canines that chase away seagulls have been helping to reduce the amount of bird droppings, which can carry disease and lead to beach closures.


All of us are road users on Uganda’s roads that have been declared one of the deadliest in the world.
UGANDA LOSES ONE PERSON PER HOUR TO ROAD ACCIDENTS
By Esther Bayiga Zziwa
The Uganda flag was flown at half-mast for 3 days as we mourned the 22 lives that were lost in a crash at Kiryandongo.
Uganda has an unacceptably high number of deaths due to road traffic crashes estimated at over 10,000 lives annually according to the World Health Organisation. That is 28 people every day that are lost and 1 person every hour. It means that technically, the Ugandan flag should be at half-mast every day all year round.
Let's also remember all those that are lost throughout the year even as we mourn the 22. Road traffic injuries are now endemic and none of us can ignore them anymore. All of us are road users on Uganda's roads that have been declared one of the deadliest in the world. As I look at the situation, I am reminded of the rat trap story.
A rat looked through a crack in the wall to see the farmer and his wife opening a package. What food might it contain? He was aghast to discover that it was a rat trap. Retreating to the barnyard the rat proclaimed the warning; "There's a rat trap in the house, a rat trap in the house! "The chicken clucked and scratched, raised her head and said, "Excuse me, Mr. Rat, I can tell this is a grave concern to you, but it is of no consequence to me. I cannot be bothered by it." The rat turned to the pig and told him, "There's a rat trap in the house, a rat trap in the house!"
"I am so very sorry Mr. Rat," sympathised the pig, "but there is nothing I can do about it but pray. Be assured that you are in my prayers. "The rat turned to the cow. She said, "Like wow, Mr. Rat. A rat trap. I am in grave danger. Duh?" So the rat returned to the house, head down and dejected, to face the farmer's rat trap alone. That very night a sound was heard throughout the house, like the sound of a rat trap catching its prey. The farmer's wife rushed to see what was caught.
In the darkness, she did not see that it was a venomous snake whose tail the trap had caught. The snake bit the farmer's wife. The farmer rushed her to the hospital. She returned home with a fever. Now everyone knows you treat a fever with fresh chicken soup, so the farmer took his hatchet to the barnyard for the soup's main ingredient. His wife's sickness continued so that friends and neighbors came to sit with her around the clock.
To feed them the farmer butchered the pig. The farmer's wife did not get well. She died, and so many people came for her funeral that the farmer had the cow slaughtered to provide meat for all of them to eat.
So the next time you hear that someone died in a road traffic crash, remember that when there is a rat trap in the house, the whole barnyard's at risk. Let's build a safe system approach with everyone concerned. We ought to stop asking; why did that crash happen and ask; why was that person seriously injured in the crash. To stop blaming the driver for the cause and severity of the crash to recognizing that road or vehicle design plays a part in some crashes, and that good design minimizes their severity.
Can we stop reacting to crashes and incidents and proactively identify highest risks and work across the whole system to reduce them? We all need to share responsibility as road users and system designers to achieve safe vehicles, safe roads, safe speeds and safe road users. The ultimate million dollar question is, how can Uganda create a ‘forgiving environment' that prevents serious injury or death when crashes occur? Unless we figure that out, the flag should remain at half-mast all year long because every life matters!
The writer is a research fellow atMakerere University School of Public Health, Trauma, Injury and Disability Project


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Source: News Bharati English09 Nov 2016 14:08:09
The enthusiasm with which common people have welcomed demonetisation tells us that this nation is now on the path to being truly great. Skepticism of sour Congress and perennially anti-Modi media camp is understandable. This divergence between self-appointed sentinels of democracy and liberalism and native wisdom of people is clearly visible now across the globe.
These developments tell us how a great leader can fire people’s imagination and swing negative mood of a nation and supposed sloth into a positive mood with energetic society, ready to contribute their mite for the national good.
Experts have been talking about the move towards plastic and non-cash economy with squeezing out of cash from market and control on the parallel economy. Some overzealous non-experts have tried to mislead people into believing that their currency notes of 500 and 1000 are now a piece of paper. This has led to uncalled of scare among unsuspecting masses making them run to retail outlets, petrol pumps, and ATMs. For people carrying legal cash, it is a just exchange of old notes and new notes. Only hoarders of massive cash need to worry and worry really hard.
Some well-meaning idiots have given strange logic that once cash is handed over to low-income people it becomes unaccountable cash and goes out of legitimate circulation. It is not true at all. Retail payment in cash doesn’t convert good money into bad money. Non-payment of tax and purchases by sellers in cash takes money out of circulation in legitimate channels and creates a parallel economy.
This cash cycle will slowly shrink after implementation of GST. Demonetization is linked to this same cycle of activities to bring all money in the country into mainstream economy as were earlier steps taken by this government. With this blow, sources of the parallel economy of purchase in cash and sales in cash without paying tax will dry up as cash will dry up, breaking this parallel cycle.
However, we need to appreciate that this demonetization will not kill black money. It will damage it hard, no doubt. And, halt its play in the market in the short term and reduce it in the medium run. This act itself will not bring such money out into legitimate cycle In the long run. 1978 demonetization did not kill a parallel economy. In fact, it grew massively in later years. The parallel economy today may be bigger the total size of the economy of 1978.
Why did earlier demonetization not give desired results?
Because demonetization needed to be followed up by simultaneous improvement in other areas that force people to opt for cash transactions. Cash transactions at a normal consumer level are not bad, per say. Is it possible to use plastic money or cards in remote villages of this nation? Obviously, not.
The truth is we have not created that kind of infrastructure so far. With the coming of electronic banking, there is still a vast part of the economy that pays through cheques. Then, there is oppressive tax regime that oppresses because of high rates and complex rules. This tax regime itself results in the creation of parallel financial channels.
To cash onto this bold step, the Prime Minister needs to take some immediate steps in next budget. Sooner the better.
- Electronic payment options fleece customers with ‘convenience charges’. If more people use these facilities, cost of running such operations will come down. For this to happen such fee must be reduced.
- Cheque transactions – Bounced cheques legislation was brought in long back, treating this as a criminal act. This was diluted through courts of law and government. This is now a civil matter. This mode is still most common in business. This goes into a loop of years of litigation. Thus, parties are stuck with bad debt and dead money for no fault of theirs. This law needs to be made stricter with resolution within a given time frame. If the intent is criminal, then a strict penalty should be imposed on the defaulter. Such laws also need to be kept out of the purview of judicial appeals that helps the defaulter than the suffering party.
- Convert Post Offices into proper banking channel. Right now it is only part banking. This is an unparalleled network that cries for better utilization.
- Spread ATMs to far off places. Post Offices could be ready places for ATMs.
- Barefoot bankers can move around in rural areas with good incentives to educate people and get them to open more accounts under Jan Dhan Yojana, its easy use etc.
- Reduce cost of transacting in plastic money or cash-less transactions. I believe India may be one of the costliest places to use plastic money. Excessive transaction charges, penal interest charges dissuade people from using it.
- The high cost of pre-paid cards – For example Indian Suburban Railways and Metros have shocking charges for buying a pre-paid charge card. For example, Mumbai Metro charges INR 150 for making a card! Indian Railways cards have an expiry date, after which your balance is lost and you have to create a new card at cost. This exploitative malpractice must stop.
- Simplify taxation procedure and returns filing - Complex cess, duties over taxes etc should be shunned. GST may resolve this problem partially. But, other areas of TDS and Income tax are still there. If we wish citizens and industry to be compliant, tax rates must be reduced so people feel encouraged to pay taxes. All over the world, lower taxes have increased revenue and helped expand the economy.
We can enjoy fruits of this highly complex operation launched by the Prime Minister if Finance Minister takes up action on points noted above. Otherwise, we may end up with a new cycle of Black Money creation, even if the cycle is smaller, but not kill it.

domain: finance


text:
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An excerpt from www.HouseOfNames.com archives copyright © 2000 - 2015
Where did the Irish Callan family come from? What is the Irish Callan family crest and coat of arms? When did the Callan family first arrive in the United States? Where did the various branches of the family go? What is the Callan family history?The name Callan comes from the Irish Gaelic O Cathalain. The Gaelic versions of today's Irish names demonstrate a link to a proud, ancient past. The name is possibly derived from Cathalan, king of Farney slain in 1028, whose name means Little Charles, and from whom the family is thought to have descended. Cathalan was in turn descended from Coleman Mor, the king of Meath and (the 133rd Monarch of Ireland).
Irish names were rarely spelled consistently in the Middle Ages. Spelling variations of the name Callan dating from that time include Callan, Callanan, Caillan, Calan, Calanan, Callen, Callin, Callon, Callinan, Callinon and many more.
First found in County Roscommon (Irish: Ros Comáin) located in central Ireland in the province of Connacht, where they held a family seat from very ancient times.
This web page shows only a small excerpt of our Callan research. Another 261 words (19 lines of text) covering the years 1027 and 1280 are included under the topic Early Callan History in all our PDF Extended History products.
More information is included under the topic Early Callan Notables in all our PDF Extended History products.
Thousands of Irish families left for North American shores in the 19th century. These people were searching for a life unencumbered with poverty, hunger, and racial discrimination. Many arrived to eventually find such conditions, but many others simply did not arrive: victims of the diseased, overcrowded ships in which they traveled to the New World. Those who lived to see North American shores were instrumental in the development of the growing nations of Canada and the United States. A thorough examination of passenger and immigration lists has disclosed evidence of many early immigrants of the name Callan:
Callan Settlers in United States in the 17th Century
- Peter Callan who settled in Cape Elizabeth, Maine in 1683
Callan Settlers in United States in the 18th Century
- Hugh Callan, who landed in Virginia in 1705
- Margt Callan, who landed in Virginia in 1705
- Charles Callan settled in Delaware in 1772
- Alexander Callan settled in Wilmington, N.C. in 1774
- Alexander Callan, aged 22, landed in Wilmington North Carolina in 1774
Callan Settlers in United States in the 19th Century
- John Callan, who landed in Allegany (Allegheny) County, Pennsylvania in 1809
- Santiago Callan, who arrived in Puerto Rico in 1816
- Thomas Callan, who arrived in Allegany (Allegheny) County, Pennsylvania in 1836
- Patrick Callan, who arrived in America in 1837
- James Callan, aged 20, arrived in New York in 1854
Callan Settlers in Canada in the 19th Century
- George Callan settled in St. John's in 1809
- Catherine Callan settled in St. John's in 1842
Callan Settlers in Australia in the 19th Century
- Peter Callan, aged 36, a labourer, arrived in South Australia in 1849 aboard the ship "Constance"
- Pater Callan arrived in Adelaide, Australia aboard the ship "Constance" in 1849
- Owen Callan, aged 18, arrived in South Australia in 1850 aboard the ship "Trafalgar"
- Roxanne Callan, aged 20, a servant, arrived in South Australia in 1855 aboard the ship "Victoria Regia"
Callan Settlers in New Zealand in the 19th Century
- Philip Callan arrived in Auckland, New Zealand aboard the ship "Stately" in 1851
- B. Callan arrived in Wellington, New Zealand aboard the ship "British Queen" in 1883
- Mr. Patrick Callan (d. 1915), American 2nd Class passenger from Chicago, Illinois, USA, who sailed aboard the RMS Lusitania and died in the sinking
- Thomas Joseph Callan (1853-1908), United States Army soldier who received the Medal of Honor
- Clair Armstrong Callan (1920-2005), Nebraska Democratic politician
- K Callan (b. 1942), American actress
- Curtis Callan (b. 1942), American theoretical physicist and a professor at Princeton University
- Michael Callan (b. 1935), American stage, film and television actor
- Colm Patrick Callan (1923-2010), Irish rugby player
- Dave Callan (b. 1975), Irish comedian based in Perth, Australia
- Father Nicholas Joseph Callan (1799-1864), Irish priest and scientist
- Kevin Callan, Canadian author, speaker, and canoe enthusiast
- The Tansill, Bender, Callan, Holmead, and other Early American Families by Xavier Bender Tansill.
- Fairbairn. Fairbain's book of Crests of the Families of Great Britain and Ireland, 4th Edition 2 volumes in one. Baltimore: Heraldic Book Company, 1968. Print.
- Johnson, Daniel F. Irish Emigration to New England Through the Port of Saint John, New Brunswick Canada 1841-1849. Baltimore, Maryland: Clearfield, 1996. Print.
- Skordas, Guest. Ed. The Early Settlers of Maryland an Index to Names or Immigrants Complied from Records of Land Patents 1633-1680 in the Hall of Records Annapolis, Maryland. Baltimore: Genealogical Publishing Co., 1992. Print.
- MacLysaght, Edward. Mores Irish Familes. Dublin: Irish Academic, 1982. Print. (ISBN 0-7165-0126-0).
- Fitzgerald, Thomas W. Ireland and Her People A Library of Irish Biography 5 Volumes. Chicago: Fitzgerald. Print.
- Shaw, William A. Knights of England A Complete Record from the Earliest Time to the Present Day of the Knights of all the Orders of Chivalry in England, Scotland, Ireland and Knights Bachelors 2 Volumes. Baltimore: Genealogical Publishing. Print. (ISBN 080630443X).
- Bolton, Charles Knowles. Bolton's American Armory. Baltimore: Heraldic Book Company, 1964. Print.
- Heraldic Scroll and Map of Family names and Origins of Ireland. Dublin: Mullins. Print.
- Colletta, John P. They Came In Ships. Salt Lake City: Ancestry, 1993. Print.
- Read, Charles Anderson. The Cabinet of Irish Literature Selections from the Works of the Chief Poets, Orators and Prose Writers of Ireland 4 Volumes. London: Blackie and Son, 1884. Print.
The Callan Family Crest was acquired from the Houseofnames.com archives. The Callan Family Crest was drawn according to heraldic standards based on published blazons. We generally include the oldest published family crest once associated with each surname.
This page was last modified on 28 June 2015 at 16:28.
on orders of $85 or more

domain: library


text:
Coronation Street spoilers sees Nina vow to kill Corey after Seb tribute jibeSeptember 29, 2021
Nina Lucas is still feeling the horrifying effects from her boyfriend Seb Franklin's murder and is becoming increasingly frustrated that the main culprit, Corey Brent, is still walking free.
But next week, Coronation Street spoilers can reveal that Nina is finally pushed over the edge and vows to kill the unemotional criminal.
After distributing homemade leaflets about Corey, Nina is left devastated and rather shocked when she discovers that he has been named in the opening line-up for County.
Not feeling satisfied with the realisation that Corey is living a normal life despite the circumstances, she vows to name and shame him.
Corrie’s Sally Dynevor 'already training' for Dancing On Ice 2021 amid line-up rumours
She later takes to social media labelling him a murderer. But how will Corey react to Nina's stance and the online commentary.
Later on in the week, Nina is still feeling evidently frustrated with Corey and his behaviour.
She then begins to curses herself for giving Corey the opportunity to play the victim and promises herself that he won’t get away with it.
Not long after, Nina approaches Daniel Osbourne and tries to convince him to run a story about Corey to hopefully garner some traction, but Daniel appears reluctant.
Corrie's Nicky star unrecognisable as she unveils glam transformation after soap exit
However Kevin Webster tries to help a desperate Nina with with her plans of shaming Corey and shows her his post match press conference.
But seeing the information at hand, Nina declares that she wants to kill him.
Later when she is driving past Seb’s memorial garden she spots Corey in there laughing on his phone
Seeing Corey's happy and joyful reaction in the cemetery, Nina sees red. But what will she do?
Despite murdering Seb in cold blood and getting away, Corey will soon face harsh consequences.
As the story line later unravels, viewers will find out that a busker reveals themselves as a witness who noticed the killer getting rid of the incriminating backpack on the night of Seb’s murder.
But due to Corey's flippant temperament, he may decide to take matters into his own hands in order to cover his tracks.
For more of the latest showbiz news from Daily Star, make sure you sign up to one of our newsletters here.
Source: Read Full Article


A provision has been removed that prohibits appointing for a minister's post someone whose nomination Rada has already rejected.
16:30, 23 February 2021
The adopted bill has resumed competition for posts in civil service.
11:05, 17 February 2021
The deputy says the issue is yet to be discussed with the Rada leadership.
22:30, 15 February 2021
The procedure for appointing an agency director could be changed.
18:00, 15 February 2021
Farmers brought and laid 37 wreaths with the names of already discontinued production facilities outside the parliament's building and were also handing out to parliamentarians and passers-by the last eggs from the agricultural holding's poultry farms, which are being shut down.
16:50, 03 February 2021
The Cabinet of Ministers must submit its proposals within a month to increase the cost of paying subsidies, which are provided for in the state budget for 2021.
15:40, 28 January 2021
The powers of the new ministry have not yet been determined.
13:10, 27 January 2021
Earlier, COVAX approved 8 million doses of a free COVID-19 vaccine for Ukraine.
14:50, 29 December 2020
It will lay the groundwork for a future strategy for the development of Donetsk and Luhansk regions.
21:59, 23 December 2020
Buslavets tendered her resignation as first deputy energy minister on December 21.
21:59, 21 December 2020
The lawmaker has named three officials in question.
19:30, 15 December 2020
The Cabinet gathered for a special meeting on Thursday evening.
21:59, 26 November 2020
The decision was made without debates.
15:55, 18 November 2020
Yet, a further deterioration will make the government impose tougher curbs.
14:29, 04 November 2020
The raids may be connected with the investigation of cases related to Oleksiy Kudriavtsev.
15:55, 22 October 2020
The cities of Ivano-Frankivsk, Poltava, Sumy, Ternopil, Khmelnytsky, Chernivtsi, and Chernihiv have been put into the "red" quarantine zone.
20:54, 15 October 2020
The ban is in effect until September 28.
15:59, 25 September 2020
The minister says the 2021 national budget draft is realistic and balanced.
13:45, 21 September 2020
At the same time, he stopped short of naming the minister in question.
16:20, 15 September 2020


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BA, MA (Trent)
Dissertation: On Forests, Witness Trees, and Bears: An Exploration of Social-Ecological and Multispecies Witnessing and Grief
Jonathan Bordo (Supervisor), Stephanie Rutherford, Stephen Bocking
External Examiner: Ashlee Cunsolo (Memorial)
Internal Examiner: Finis Dunaway
Chair: Michael Epp
This dissertation is about Forests, their loss and the grieving that arises from their loss. The loss of ancient and old-growth forests by way of clearcutting and or anthropogenically driven disturbances, including climate change, presents the quandary of loss of both biological and cultural diversity. Following Umeek’s/E. Richard Atleo’s term, I suggest that “dis-ease” in the dominant relationship to forests in parts of the Western world significantly rests within inherited cultural and political pasts at play in the present, carried in much of the language and lifeways of modern Anglophone societies today. I do so by a critical topographical exploration of thematic patterns that go back to the Epic of Gilgamesh, the oldest written account of deforestation in the history of Western civilization. I offer at the center of my inquiry a collection of witness trees as North American case studies. Each tree is a witness object, a station from which I confront and explore social-ecological grief as it has accumulated over time from English colonization, with one focusing on Indigenous cultural reclamation and place-based ecological co-management. Lastly, I turn to a multispecies exploration of social-ecological grief, using bears in North America as a face for reflection and consider who and what more is lost when old forests are degraded and gone. By asking the place question—“what place is this?”—of forests, or the Forest Question, my dissertation is thus an exploration of the connection and responsibilities to other place-based human and other-than-human communities in a rapidly changing climate.


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Awesome milk trick!.
House hold Hacker- owns this video.
Origami Magic Rose Cube (Valerie Vann)
How to make an Origami Magic Rose Cube. It is a cube that can be transformed into a rose with a few simple moves. Green and Red modules are made with the sam...
3 year old Genius
This 3 year old artist is AMAZING
The Shrike - On the Cutting Edge Exhibition (Library of...
Psychadellivision by ~Volcanic-Penguin on deviantART
Alright, just because you people liked it so much (and I think you're crazy for doing so) I've updated it a bit. Well, quite alot actually. So now it's ...
Spike Jonze captures Yo-Yo Ma & Lil Buck performance
Spike Jonze was lucky enough to be at an event to bring the arts back into schools and caught an amazing collaboration between Yo-Yo Ma and Lil Buck
» 12 Art & Design Documentaries You Should Queue
12 Art & Design Documentaries You Should Queue - Banksy didn't win an Academy Award, wasn't spotted at the show and didn't even bother to vandalize the Kodiak Theater restrooms - disappointing stuff,


text:
Isocitrate dehydrogenase 1 mutant R132H sensitizes glioma cells to BCNU-induced oxidative stress and cell death
- 937 Downloads
Isocitrate dehydrogenase 1 (IDH1) decarboxylates isocitrate to α-ketoglutarate (α-KG) leading to generation of NADPH, which is required to regenerate reduced glutathione (GSH), the major cellular ROS scavenger. Mutation of R132 of IDH1 abrogates generation of α-KG and leads to conversion of α-KG to 2-hydroxyglutarate. We hypothesized that glioma cells expressing mutant IDH1 have a diminished antioxidative capacity and therefore may encounter an ensuing loss of cytoprotection under conditions of oxidative stress. Our study was performed with LN229 cells stably overexpressing IDH1 R132H and wild type IDH1 or with a lentiviral IDH1 knockdown. Quantification of GSH under basal conditions and following treatment with the glutathione reductase inhibitor BCNU revealed significantly lower GSH levels in IDH1 R132H expressing cells and IDH1 KD cells compared to their respective controls. FACS analysis of cell death and ROS production also demonstrated an increased sensitivity of IDH1-R132H-expressing cells and IDH1 KD cells to BCNU, but not to temozolomide. The sensitivity of IDH1-R132H-expressing cells and IDH1 KD cells to ROS induction and cell death was further enhanced with the transaminase inhibitor aminooxyacetic acid and under glutamine free conditions, indicating that these cells were more addicted to glutaminolysis. Increased sensitivity to BCNU-induced ROS production and cell death was confirmed in HEK293 cells inducibly expressing the IDH1 mutants R132H, R132C and R132L. Based on these findings we propose that in addition to its established pro-tumorigenic effects, mutant IDH1 may also limit the resistance of gliomas to specific death stimuli, therefore opening new perspectives for therapy.
KeywordsBrain tumor Glutaminolysis Cytoprotection Oxidative stress Glutathione
We thank Gabriele Köpf and Hildegard König for excellent technical assistance.
This study was supported by the Deutsche Krebshilfe (Grant 108795).
Conflict of interest
The authors declare no conflict of interest.
- 3.Stupp R, Hegi ME, Mason WP, van den Bent MJ, Taphoorn MJ, Janzer RC et al (2009) Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol 10:459–466PubMedCrossRefGoogle Scholar
- 9.Paschka P, Schlenk RF, Gaidzik VI, Habdank M, Kronke J, Bullinger L et al (2010) IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication. J Clin Oncol 28:3636–3643PubMedCrossRefGoogle Scholar
- 12.van den Bent MJ, Dubbink HJ, Marie Y, Brandes AA, Taphoorn MJ, Wesseling P et al (2010) IDH1 and IDH2 mutations are prognostic but not predictive for outcome in anaplastic oligodendroglial tumors: a report of the European Organization for Research and Treatment of Cancer Brain Tumor Group. Clin Cancer Res 16:1597–1604PubMedCrossRefGoogle Scholar
- 13.Hartmann C, Hentschel B, Wick W, Capper D, Felsberg J, Simon M et al (2010) Patients with IDH1 wild type anaplastic astrocytomas exhibit worse prognosis than IDH1-mutated glioblastomas, and IDH1 mutation status accounts for the unfavorable prognostic effect of higher age: implications for classification of gliomas. Acta Neuropathol 120:707–718PubMedCrossRefGoogle Scholar

domain: medical


text:
Pacific Palace Hotel is conveniently located in the popular Nagoya area. Located on the outer rim of Nagoya, only 5 minutes from Nagoya Hill Shopping Mall, the Pacific Palace Hotel offers a convenient shuttle service. It features an on-site gym, a sauna, an indoor pool and a jacuzzi.
The Pacific Palace Hotel has a day spa, offering a range of relaxing treatments and beauty therapies. It also features a concierge, a 24 hour reception and a lift. There is a safe, a business centre and a kids pool, and Wi-Fi is available.
All large rooms at the Pacific Palace Hotel are air-conditioned and offer a TV, a private bathroom and cable / satellite channels. Make a fresh coffee in the privacy of your room with the available in-room facilities and free supply of coffee and tea. Bathroom amenities include a separate bath and a shower.
The Pacific Palace Hotel has a restaurant and an on-site bar. Alternatively, there are numerous eating options around the hotel. Room service is available around the clock.
Places of interest close to the Pacific Palace Hotel include the Mega Mall Batam Centre and Batam Island. Hang Nadim Airport (BTH) is a 30 minute drive away.
Check Availability and Booking
- Rating: 4 stars
- Check in time: 02:00 PM
- Check out time: 12:00 PM
- Number of rooms: 180 rooms
- Number of floors: 8 floors
- Year opened: 2008
- Official website: http://www.pacificpalacehotel.com/
Address and Map
Address: Jln. Duyung Sei. Jodoh, Nagoya, Batam, Indonesia
Pacific Palace Hotel Facilities and Services
Featuring a complete list of amenities, guests will find their stay at the property a comfortable one.
- Room Service, Restaurant, Bar / Lounge, Air Conditioned, Non-Smoking Rooms, Mini Bar, Refrigerator, Cable / Satellite TV, Coffee / Tea Maker, Hair Dryer, TV, Shower, En suite, Private Bathroom.
- Fitness Room/Gym, Swimming pool, Tour Desk, Massage / Beauty Centre, Sauna, Bath / Hot Tub, Excursions, Karaoke, Nightclubs, Jacuzzi, Massage, Spa & Wellness Centre, Facial Treatments, Child Pool, Pool Indoor.
- Business Center, Concierge, Elevator / Lift, 24 Hour Reception, Dry Cleaning, Banquet Facilities, Currency Exchange, Safe-Deposit Box, ATM / Cash Machine, Meeting Rooms, Shops, Photocopier, Ticket Service, Ballroom, Luggage Storage, Shops in Hotel, Souvenirs/Gift Shop, Shoe Shine, Self Laundry.
- High-speed Internet is available at this hotel. Wireless internet on site.
- Valet parking is offered at the hotel.

domain: travel


What is a multi-cloud environment?
A multi-cloud environment is where more than one cloud computing is used. It might be a combination of public, private or edge clouds. These clouds may be used in various combinations in order to distribute applications and services.
A multi-cloud environment, for example, might be used to speed up the delivery or transformation of apps. Or, an enterprise might consider spreading across different clouds so that it’s not dependent on one vendor. Some applications, such as logistics, retail and manufacturing may need to be distributed at the edge to be physically closer to users and deliver faster results or better customer experiences.


text:
Robert E. Anderson
September 16, 2022
University finalizes settlement in Anderson cases
A January settlement between U-M and attorneys for more than 1,000 claimants who alleged abuse by the late physician Robert E. Anderson has been approved by all parties and finalized.
August 3, 2022
Ruling paves way for new programs targeting sexual misconduct
A federal district judge has approved a settlement in a class-action lawsuit that creates a broadly representative team designed to further protect the U-M community from sexual misconduct.
March 24, 2022
New team to further protect university community from sexual misconduct
U-M and attorneys representing plaintiffs in a class-action lawsuit have agreed to settle claims in the case with the creation of a broadly representative team designed to further protect the university community from sexual misconduct.
January 19, 2022
U-M reaches $490 million settlement with Anderson plaintiffs
U-M and attorneys for claimants who have alleged abuse by the late physician Robert E. Anderson have reached a settlement agreement that would resolve all of those survivors’ claims against the university.
May 11, 2021
Report: U-M officials overlooked ‘destructive pattern’ of misconduct
An investigation into the allegations of sexual misconduct by former U-M physician Robert E. Anderson found he engaged in a “pervasive, decades-long, destructive pattern of sexual misconduct” involving hundreds of U-M students.
June 16, 2020
U-M reaching out to former students in Anderson case
U-M will send a message to more than 300,000 former students asking them to share information that may be helpful to an independent investigation into allegations of sexual misconduct by the late Robert E. Anderson.
April 28, 2020
University will create process for resolving Anderson claims
U-M will develop a process outside the court system to address claims of sexual misconduct brought forward by former patients of the late physician Robert E. Anderson. The goal is “more certain, faster relief” for those who have come forward.
April 7, 2020
U-M contacting former student-athletes in Anderson case
U-M is reaching out to thousands of former student-athletes who may have been patients of the late team physician Robert E. Anderson, asking them to talk with independent investigators.
March 24, 2020
U-M hires WilmerHale to handle Robert E. Anderson investigation
The WilmerHale law firm will take over the independent investigation into allegations of sexual misconduct regarding the late Robert E. Anderson, who worked as a physician for U-M from the 1960s to 2003.
March 6, 2020
New statement regarding reports of misconduct by Robert E. Anderson
The Board of Regents and President Mark Schlissel say they are “profoundly grateful to our courageous alumni who have stepped forward to hold our University accountable” in the sexual misconduct case of the late U-M physician Robert E. Anderson.

domain: news


If Teacher Hears ‘Schools Are Safe’ One More Time She’s Going To Scream
STARING at a depleted class room down several pupils due to an outbreak of Covid-19 which is not being classed as having occurred in a ‘class room’ setting, local teacher Tríona Moore has confirmed she won’t be held responsible for her actions if and when someone utters the phrase ‘but schools are safe’.
Moore, a negative moaner of epic proportions, maintains that the Dept. of Education and other authorities haven’t provided the resources and help needed and that suggesting she ‘leave a window open’ doesn’t count.
“Y’know what some people are like – any excuse to moan,” confirmed a Dept. of Education official, who can’t believe teachers are sore over the department’s decision to do absolutely nothing differently with schools compared the last time they reopened and closed.
“I’m only 5ft 4 inches but I wouldn’t fancy the chances of whatever prick tries telling me schools are safe,” Moore said to a socially distant colleague, who’s temping for a teacher who is off with Covid but shush no one in school needs to know that, she probably caught it off a gust of wind that crept into her house through a draft excluder.
Standing in the yard, staring out at several siblings of another pupil not in school today because they’re off awaiting the results of Covid test, Moore had the sneaking suspicion that their was a better way to ensure the safety of workers, pupils and their families than the government trying nothing before immediately admitting defeat.
“And it’s a panic over nothing, sure schools are safe,” shared one parent conducting an essential chat session with 60 other parents crowded around the school gates moments before being pounced on by Moore.


text:
gorgeous! What a sweetie!
Dit plaatje ziet eruit om geschilderd te worden schitterend gewoon mijn compliment groetjes Danielle
Who can resist that adorable little face, a bundle mischief I bet, Gayle, beautiful postcard!
A wonderful piece Gayle. Love that little dog! xx
This is the best one so far. It's lovely, well doneLynn
ohhhhhhh, this is só cute
Oh he is soo cute a darling postcard Gayle!
Adorable, Gayle. And a really different take from other mostly vintage cards.
I love the wonderful, rich tones of that paisley, and the punch of the orange reflections, not to mention that adorable pooch!
Out of this world!!!!!!!!!!!
What a sweet dog! Beautiful postcard too!
too SWEET and so perfectly CUTE
Post a Comment


Sri Lanka Podujana Peramuna (SLPP) Dehiwala- Mount Lavinia Organizer and former Mayor Danasiri Amaratunga has slammed Government leaders after local area representatives were snubbed from the inauguration ceremony of the Kohuwala flyover project.
He said the Local Government authorities, Councillors, and especially he who is the party’s organizer for the area, had not been informed of the inauguration of the construction work for the project which was held yesterday.
Danasiri Amaratunga further said it was regrettable to see high-ranking officials of the Government forgetting the lower level party members who worked hard to ensure the Government was elected to power.
The foundation stone for the construction of the new flyover at the Kohuwala junction in Colombo was laid by Minister of Highways Johnston Fernando and the Hungarian Minister of Trade and Foreign Affairs Péter Szijjártó yesterday.
The Hungarian Foreign Ministry said the flyover at the Kohuwala junction will be constructed with financial aid from the Hungarian Government at a cost of Rs. 2,648 million.
The overhead bridge would be 217.30 meters in length and 9.4 meters in width overarching a four-lane road connecting Nugegoda and Kalubowila controlled by traffic signals, while the project is expected to be completed in 22 months. (NewsWire)


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25-27 March 2015
For the second consecutive year, Saniharto participated at HI Connect 2015 in Nashville. This year we collaborated with Hirsch Bedner Associates (HBA) based in Atlanta to create a luxury guestroom vignette. Saniharto made the Headboard, Bed, Nightstands, Desk, Portal, Wardrobes, Frames, TV Wall and Minibar.
Eucalyptus wood was the veneer of choice for all these pieces. With all the other items like artwork, bedding, seatings, rugs, lighting, etc, supplied by other vendors, the vignette turned out to be very elegant and high-end.
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