Manufactured products are becoming more complex — and the process to create them is also becoming highly complicated, particularly since the recent coronavirus pandemic has disrupted supply chain systems around the world. That disruption is just one of the reasons manufacturers are turning to a process called manufacturing optimization to move products from the design table to the production line faster and with less waste.
To put it simply, process optimization in the manufacturing industry is the ability to use data to make processes go faster. There are three basic areas that can be leverages for process optimization in the typical manufacturing scenario: Supply chain optimization, product design optimization, and enterprise resource planning (ERP). That last piece of the puzzle, ERP, is where managed print can assist manufacturers in optimizing processes for streamlined, efficient outcomes.
Optimizing Processes Using the Power of Managed Print
Enterprise resource planning (ERP) is used by modern manufacturing organizations to automate those functions that have to do with business performance. From managing customer experiences to finding ways to provide greater visibility into financial areas, ERP is valuable across many aspects of the manufacturing lifecycle. Things like inventory control, purchasing, sales, and operations can all benefit from the application of ERP.
Managed print solutions are the perfect way to introduce process optimization into a much-overlooked aspect of the manufacturing floor — the print and imaging process. Manufacturers rely on print output for invoicing, billing, and the production of marketing collateral, product manuals, and more. Importantly, many organizations are simply not aware of their current expenditure on printing, which not only includes paper, but also infrastructure, maintenance, and other supplies such as ink and toner.
The Promise of Managed Print
A managed print solution can bring targeted visibility to your print spend, help you determine how each machine is being used and by whom, and assist in the optimization of your print infrastructure for streamlined workflows and cost reduction. Here are a few targeted ways managed print can help you optimize your print process:
A managed print services (MPS) program provides everything you need for your printing processes — infrastructure, supplies, maintenance, and services — for one predictable monthly cost. MPS helps to centralize vendors, streamline workflows, and relieve the burden of printer-related IT tasks from your in-house IT team.
Your MPS partner will analyze your current print strategy, determining which machines are underutilized and which departments need more print support. Then, they will create a plan to consolidate your current printer fleet that focuses upon the maximization of efficiency and centralization of all printer-related information and tasks.
Automated Supply Replenishment
On the busy factory floor, there is not time for slowdowns caused by machine downtime. The same is true of your print infrastructure. An MPS partner will use secure software to accurately predict exactly when each print device needs ink and toner so that it is delivered exactly when it is needed. Not only does this method remove the need for expensive supply storage solutions, but it prevents overbuying and stockpiling of supplies for those “just in case” moments.
Predictive Analytics and Security
Using machine learning and artificial intelligence technologies, today's MPS analyze usage data and compile reports that help you gain insight into print spend — and where you can reduce costs. Additionally, MPS programs offer access control features to reduce the possibility of physical theft of printed proprietary information and remote monitoring for unauthorized access of printer endpoints.
Blue Technologies Takes Managed Print to the Next Level
Since the pandemic, it has been more important than ever for manufacturers to focus on optimizing processes from the production floor to day-to-day functions such as printing. With supply chains still reeling and markets still volatile, paying attention to cost-saving and process optimizing tasks can make the difference between business success and barely surviving.
At Blue Technologies, we have curated leading-edge managed print technologies that can offer you a variety of advantages to assist in optimizing your print environment. From enhanced visibility and security to better machine reliability and unparalleled support, our MPS program can help you gain control of print-based tasks, costs, and security.
Optimizing processes? Don’t forget your print environment. Contact a Blue Technologies consultant to discover how our MPS program can help save you time, money, and peace of mind.


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FlyingTurtle FlyingTurtle - Here, we have a turtle that wants nothing more than to see the world. Sadly for him, his slow speed makes travelling long distances a big problem. Then an amazing idea suddenly comes to him; he can lie on his back and glide over hills at great speeds! And so, as a problem is solved, a journey begins..
The Three Musketeers The Three Musketeers - All for one, one for all! Follow in the footsteps of the Three Musketeers as you solve the mystery of the recent wave of assassinations. You play as Anry, son of Aramis, with a lot to live up to as you attempt to emulate your Father's success with The Three Musketeers
Sturmtrupp Mars - Operation Roasted Bugs In this new action-strategy-blockbuster Sturmtrupp Mars– Operation Roasted Bugs, HandyGames™ sends its fans to the red planet, which is threatened by hordes of extraterrestrial bugs
itsmy FJBs Pumpkin Attack itsmy FJBs Pumpkin Attack It's Halloween time and Farmer John-Boy is enjoying his short holidays on good 'ol Earth! Or was enjoying until the vicious uranian aliens started their 'snatch-a-cow' offensive disguised in this year's #1 halloween costume, 'The-Pink-Bunny' - like all hillbilly kids in town.
Fighter Plane Fighter plane is a challenging, interesting and addictive game about flying
Chef ninja Chef ninja - ingredients are flying in the air, ninja skills are required! The clients like the show and like to be served fast
Rescue Frog Rescue Frog is puzzle game where you have to help the frog to reach his island by jumping on leaves
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JavaMobiles - Free Java games download for mobile phones. Java Applications, Software, JAR, Apps for Nokia, Samsung, touch screen, 240x320 screen

domain: entertainment


text:
Please explain the shift in style of music as it relates to musical texture (monophonic, polyphonic) as well as the ensembles and places we see/hear music. I.e. the shifting of music from the church to the secular.
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domain: artistic


text:
It is essential for everybody to seek medical attention in case of sickness, injury or any type of accident. Many at times we do not receive the care we want and this may lead to worsening of the condition. It is therefore wise to consider all the precautions available for you to get the best care and service when such events happen. One of the decision to make is to have a personal injury doctor. In this case you can access the care you want at the time that the injury occurs without any fear of being mishandled. The personal injury doctor should have desirable characters that will make you have confidence in him.
Firstly, inquire on the qualification of the personal injury doctor. The qualification of any doctor entails learning in a qualified institution and getting both theoretical and practical skills to be able to handle patients. Registration and licensure by the professional body is made once has completed the studies and done the relevant exam. In case you are in doubt, getting the license and certification of the personal injury doctor will clear your doubts. Off course you cannot wish unqualified doctor to give you medical services.
The years of practice that a personal injury doctor has worked is very integral during the selection process. All hospitals that a particular personal injury doctor has worked can be helpful in determining his level of experience. You can also ask for the number of years that he has been in a specific specialization or the number of people he has attended to. If you need the best personal injury doctor, look for the one who has a long experience in dealing with accident and other forms of injury cases.
Always be quick to ask on the times that the personal injury doctor is available. This is because the accidents or injuries happen in different times and have a high level of uncertainties. A personal injury doctor is supposed to be available at any time that you need him. They should be no cases where a doctor is called and yet he is out of the country or cannot be reached on a mere phone call. Your heart is at ease when you are sure that your personal injury doctor is a call away.
Lastly, you should ask the personal injury doctor to name the charges that he makes for any services that he offers. The costs will dictate if you are to go ahead and hire him or not. Remember to always stick to your budget. We are bound to get injuries at different times of the year and so hiring a fairly charging doctor will do no harm.

domain: health


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Reviews & Ratings
Track reviews from the iOS app stores, globally. Find out what people think of Basketball Arena by reading the reviews and checking the rating. See the most helpful app reviews of Basketball Arena written by users who played the game or used the app and let others know which reviews you have found the most useful by rating them up.
User Reviews for Basketball ArenaReviews: 146Avg. Rating: 9.2/10
PLEASE ADD 2v2 WILL MAKE THE GAME BETTER
The best game ever and for MrBeast
Best game ever but it makes you spend money
It’s a really good game it’s really fun you can battle your friends but it makes you spend money if you want to get like a
season pass it’s annoying
Super great game better than 2K
This game is very enjoyable and fun. This game should be on the top charts. I really advise this app. If ur not playing it ur
missing out. So hop to it and play this #1 game.
ADDICTED TO THIS GAME! Roblox account: Poopy
LIKE I’M SUPER ADDICTED I USUALLY PLAY WOTH MY BROTHER SOMETIMES AND I ALWAYS GET ADDICTED EVERYTIME I SEE THIS APP IM LIKE I AM
GOING TO PLAY!, TO WHOEVER MADE THIS APP THANK U SO MUCHHH
Stop being mean
Stop being mean now it’s just a game okay
Best game ever now I no what is going to take over fortnite
I love basketball arena
Basketball arena is the best bb game I have ever played so thank you AppStore for making this game and my dream come true.I’ll
love bb so much and my dream is get into the NBA and this is perfect practice.
it is not complete
The game is very good and I recommend it. The game is fun, but after a while it becomes boring and monotonous, I think if the
clan had, it would be boring, if you do not think about change, I think this game will lose its fans, and if it changes well.
Awesome game 😃
My friend just wanted me to get this to play with him but this game is really good and I’m gonna keep playing
Great Game but...
This is a great game. But here is what is wrong. #1: maybe some replays? That would be really cool. #2 it is pay to win. If you
are poor and can’t spend money I wouldn’t recommend this. 1 character is $100 like what!? This is unbelievable, the most
I’ve ever spent on a game is $10 and it was worth i
You should get this game
I love this game so much. You have so many different options to play. You get daily rewards. Thanks so much for making this game.
The best game ever!!!!!
This game allows you to buy cheap bundles. It has 1 ad per hour and also lets you play with other players. It gets intense when
you unlock a new character. I love this game. There is so much more great information I can give, but I need to check what’s new
Great Game But I Have A Suggestion
Love the game but would be more fun with tournaments, like you join a tournament and if you win you play someone else that won,
and if you lose your are out the tourney.
BasketballArena is soooooo fun
Me and my friend play this all the time we both think it’s an awesome game!!😀😀😀
SO ADDICTIVE! 🤩
Let me just say right off the bat that this is an amazing game, with tons of cool features. I really don’t need to say much more
other than, too many ads but that’s it, keep up the great work😀
This a great game🤩
I love it I know it has adds but the game is really good. But if you think about it you can like it to! So if you try it and you
like basketball you will like BasketballArena.
Game is great. Tons of fun. They give you a lot of opportunities to get free stuff. The only problem I have is half the time the
ads don’t load. I don’t have any problems on any other game including games from this company. Would definitely be 5 star plus
if not for this.
I like the game
I got bored after a while, but this game is actually a pretty good basketball game. :D but there’s this bug that keeps
happening.. randomly when I play the game it freezes ;-; when the game gets more popular, can we have a championship? id like to
compete in it since im good at the game now.
Great Sports Game
This game is so great, and so filled with different ways to play.
Firstly, I like that you don’t need to pay to play. I have beaten multiple teams with Lebron and all superstars. There are so
many nontalented people with talented players that can’t play.
One thing that I would prefer is faster seaso
I think that basketball arena is a REaLlY Addicting game I mean 2 days ago I got into the college league and now I’m already in
first place on the leaderboard and I’m really close to unlocking one of the superstar cards and what makes it even better is
that I have level3 for all my rookie cards and
Pay to win
It’s just a greedy game nobody should play this crap
BasketballArena is the best game ever since nba 2k
If you have no choice of the day you can have fun
The game is godly and it also loves poop but I wish that three pointers would be at the three point line and twos would beonly in
the paint and I love the because of
This game is awesome I really love doing 3pointers I love the game.
ONE OF THE BeSt GAMES!!!
I know there’s a lot of people saying this game is pay to win but it’s really not there just bad at the game so they don’t
get chest fir better characters also there’s not that many adds and you don’t need tokens to play if you get enough fans you
can open chests inastantley witch will give you more
This game is the best
Bro nobody can make a better game then this like it just like real life out here in this game this game is the best hands down
I love this game it’s super fun!!!
Credit For Friend Invites But...
Being able to invite friends to play saves the game for me because I’m not thrilled about the many CPU opponents you face that
play unrealistically particularly when it comes to constantly recovering from steals and being able to steal your ball after a
well timed block. If your challenge to overcom
I like playing against real people too
This is one of the best mobile game I have ever played
The fun times 😆!
Basketball arena is so much fun. You can do so much stuff
And friend so much people . And for those of you out there who are reading this you should download it NOW! You can’t unlock
so much the characters and play so much games no matter how much you loose you will have so much fun.
How much I love basketball arena
I love this game so much i play it like 5 hours a day
Yes it so 5 star
It good game I love it I play basketball myself so I really like this game
This is a short review but say I freeze someone with the freeze power. And they freeze me back... like why would it even be
possible to use powers when their frozen it’s just annoying. Overall great game!!👍🏼👍🏼
This game is super fun and is so good. There are a lot of good things about this game like how you can play friends and customize
your team. Other comments say that this game is pay to win but I kind of disagree because yes it gives you the option to spend
money but I’m doing really good In this gam
This game is one OF THE BEST GAMES I HAVE EVER PLAYED. Most reviews I read people said it was kinda bad and that you had to pay to
win but I don’t know if that’s true but If it is that would be pretty bad. So far in the game I’m getting a lot of coins,
diamonds and a lot of other cool stuff you can
I’m not going to lie I mess with this game it’s fun mane exiciting plus u can play with fans it’s lit i totally suggest
y’all get it ‼💯
Love the game
This is the best game of n the world get it now or you will be doomed it even has super powers please get it it is super duper
Can’t but no ads buy you can buy everything else🤦🏽
Can’t but no ads buy you can buy everything else🤦🏽♂
Best game (read description)
THE WHOLE GAME IS PAY TO PLAY YOU CANT DO ANYTHING WITHOUT PAYING WHEN YOU GET UP TO A CERTAIN POINT SO DO NOT GET THE GAME UNLESS
YOU WANT TO SPEND YOUR MONEY! IVE BEEN PLAYING FOR 3 DAYS AND CAN NO LONGER PLAY BECAUSE I WOULD HAVE TO SPEND MONEY SO I CAN GET
ANYWHERE IN THE GAME ITS AWFULL!
This game is insane
This game is insane because you can play with your friends. It’s also so fun. Even though you have to spend money on some people
to get them. The A.I is kinda like your level or just a little worse. When you play the game a lot it gets more fun. The only time
you get adds are when you can get power
A Glitch In challenging your friends
When I invite my friend to a 1 on 1 the game glitches and does not let me or my friend move! Please fix!
It is a sports and I like it ind I am 1 for 5 k
I don’t know how to explain how good this game is
My name is scummm
Thank you to the creators of this game whoever made it I appreciate you extremely.
The game is actually extremely fun if you play super good they might send you a warning for cheating write a review let them kno
they’ll fix it.
Basketball Arena Rocks!
Amazing Fun Game! I Saw Some Youtubers Play It & I Play It All The Time At Work & Home!
Pretty cool game
definitely needed a game like this in the App Store
Basketball arena is a fun game, you will not regret trying it. Basketball arena is making a huge 50,000$ giveaway, so you have a
chance of winning it. So download basketball arena and start winning games. Good luck:)
I love This Game!
This is the best game ever because we can verse friends! And compete tournament’s.
This game has gave me hours of enjoyment but it’s a bit pay to win and it feels like bots are legit cheating
Fix your glitches so if someone loses connectivity 2 or 3 times, they forfeit. Makes no sense that someone is allowed to lose
connectivity for 15seconds an infinite number of times. Meanwhile they’re game comes back up and you’re behind 1 or 2 plays.
My cousin wants you to make cards people
This a fun a fun game but very pay to win
New update has my app crashing after every game.
Title says it all.
There isn’t any real fairness in this game to the players that simply spam the steal button each time you get the ball. There
should be a pause or a delay to it.
My tag name is EmirtusBallR
It is an incredibly cheap tactic that i see mimicked by many players. I don’t do it cause
Not bad but annoying at times
I have made the top division and even top 100 in the game but the mechanics need to be tweaked just a bit more I find players
somehow grabbing the ball while they’re in front of it and the ball is behind them little things like that very annoying and
unfair to play against but overall not a bad game
It’s a fun game where the skills are easy to learn and the mechanics and stats are surprisingly balanced. However this game is
still very much pay to play, my biggest gripe is in the energy and power up usage. When I started they gave me a surplus to use so
I never realized they were limited. I now
It needs some work
This game is not that good because all you do is face bots that have nothing above a 4 streak win if you were to face better and
real players it would make it much better
Fun but expensive
Definitely a fun game that I’ve really enjoyed since downloading a few days about. The biggest downside is that you definitely
need to spend money often if you want to be competitive. Tokens to play (coach “contracts”) don’t come nearly frequently
enough unless you buy them. Super powers cost a lot
This is a great game it’s just that anything that hits the rim goes in
Game was really fun and I could play all day until they added all of these annoying ads you have to watch after every match.
Pay to win over powered
I never write reviews about games but after playing this game for a few months I got a few words that people need to know. The pay
to win is insane in this game if I had half of the characters some of these kids payed for I would be unstoppable. The matchmaking
needs to be fixed it’s fine that the t
Game is fun but unfair
This would be the best game ever, if the matchmaker was more fair...
Overall great game. But matchmaking should be reduced to +/- 2 levels instead of 3. Also should consider which coach is being
used. Matchmaking should focus on strength of roster with consideration to what coach is being used instead of player level.
WRITE YOUR OWN REVIEW
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domain: hobby


Starting October 11th, Japan will reopen its doors to visa-free and individual tourists. They are also doing away with their daily arrival cap.
Prime Minister Fumio Kishida announced the changes on Thursday during his visit to New York for the U.N. General Assembly. Japan has been notoriously cautious in reopening to tourists and has practiced strict restrictions amid Covid. Now, the island country is hoping to fully reignite its tourism sector by opening up to all visitors.
Japan may also introduce a nationwide domestic travel program that offers discounts on things like hotels, restaurants, and transportation. The program aims to help bolster the industries that were badly affected by Covid and can save people up to about $35 per night on accommodations alone, which can certainly add up.
Tourists will still need to be vaccinated three times or submit a negative Covid test before visiting.


Norman Swan: Hello, and welcome to the Health Report with me, Norman Swan. Today, the genetic mutations that see cancer risks cascade through generations of families.
Michelle Brady: I was, like, how does a 14-year-old child get a second primary cancer? You know, this is not a spread. That doesn't happen, there is obviously something more going on.
Anna Murphy: I think it's there every day, it's like you look in the mirror and you see scars from surgeries you've had. I don't think I don't go a day without thinking of it.
Norman Swan: More than two decades ago, a major milestone in cancer was reached with the discovery of the BRCA1 and BRCA2 genes. Inherited mutations to these genes can dramatically increase the risk of developing breast and ovarian cancers. This knowledge opened up new ways of knowing who is at risk of cancer, how to treat it and even how to prevent the cancer ever happening in the first place. Since then, many more inherited gene mutations have been found, linked to other types of cancer. What does this mean for the families that have seen generations of loved ones endure sometimes multiple cancers? And the emerging frontier in medicine trying to change that. This feature has been made by Sarah Sedghi.
Michelle Brady: Addie was…wow, she was an incredible young child, very, very bright, very, very beautiful. I know a lot of parents say that about their children but she truly was. She had a zest for life and that all came crumbling down when she was just nine years old.
Sarah Sedghi: Michelle Brady remembers how brave and selfless her daughter was as she went through treatment for a rare form of bone cancer. Her tibia had to be removed and was replaced by a prosthetic bone in her leg, and there were months in hospital having chemotherapy. Michelle says her daughter adapted, recovered and continued to live her life fully and joyfully.
Michelle Brady: I call it like a blip in her life and life would carry on, and it did. And then when she was 14 she got up one morning and just out of the blue, there were no signs of any of this, this is five years on from her first cancer, she was unable to speak and she had a seizure and she was rushed to hospital by an ambulance. And in a couple of days after that, we were advised that she had an inoperable brain tumour. Treatment was only available to extend life rather than save life, which was incredibly hard for us as parents to hear.
Sarah Sedghi: Michelle Brady knew something more was going on. It didn't make sense that her young daughter could have two different cancers in such a short time.
Michelle Brady: And deep down I know, even at 14, Addie knew the seriousness of cancer because at nine years old she had experienced it, she had seen children that she had been on the ward with lose their lives to cancer, so she knew, and she knew that a brain tumour was really, really bad. And during the time before we did lose her, she asked me probably twice, 'Am I going to die, Mum?' And it was probably the toughest questions I've ever had to answer, but I think deep down Addie knew where it was going.
And especially the last few months of Addie's life, the cancer really became quite brutal. It moved to her spine, so it ended up taking her mobility. It then started impacting her sight. Trying to get on top of the pain for Addie was very, very hard, and it was brutal. I saw a change in her…I wouldn't say personality, her personality was always there and it was always trying to break through and shine through, but it became a tough fight for her because trying to deal with living with pain constantly was a struggle, and you saw it started to have an impact on her, and the bright beautiful Addie that we knew started to change, and that was heartbreaking, to watch her experience that and for us watching her go through it and not being able to do anything about it.
Sarah Sedghi: Addie died in February 2018. She was only 16 years old. When Michelle tells me about her daughter's warmth and radiance, she says her daughter wouldn't want her to be sad, she'd want her family to continue to love life as much as she did. Michelle's instincts about the cause of Addie's cancer had been right. After Addie had been diagnosed with cancer a second time, genetic testing revealed she had Li-Fraumeni Syndrome or LFS. It's an inherited mutation to the TP53 gene. The gene is known as the guardian of the genome because it stops cancers from forming, but for people with LFS, this process goes awry and the gene can't always stop cancer from forming. It leaves people at risk of multiple cancers. Discovering this mutation can have generational consequences as it can be inherited, but in Addie's case she had what's known as a de novo mutation, meaning the first person in the family to have the mutation.
In a Sydney lab, researchers are using tumour cells from children with cancer to see what drugs they respond well to. It's just one part of the emerging field of precision medicine, a growing frontier in cancer treatment.
Mark Pinese: Really our vision is that one day there will be a time when children do not have to be treated for their cancer, and that's what my team is really working towards.
Sarah Sedghi: Dr Mark Pinese is the team leader of Personalised Medicine at the Children's Cancer Institute. His team is looking at inherited and de novo gene variants some children are born with that put them at risk of cancer.
Mark Pinese: If we can identify those kids who are at risk of cancer, then in the future we might be able to have drugs at hand that we can give these children, relatively minor drugs that they can take that will take away their risk, that they just don't develop cancer at all, and that for us is the ultimate goal and so much better than a cure.
Sarah Sedghi: For all cancers, whether beginning in childhood or adulthood, there are genetic changes that occur, and usually factors like lifestyle and the environment are involved too, but here we are talking about cancer-causing gene changes that are inherited, not acquired. Having an inherited gene mutation is not a guarantee that cancer will develop, but it does put people at much higher risk, often at a younger age. The type of mutation determines how high that risk is. Inherited genes are behind 5% to 10% of all cancers.
Mark Pinese: Precision medicine is maturing, so the idea was in the start we look at a tumour, we find out what makes that tumour tick and then we find the drug for it. I think now we are starting to look even broader and we are starting to understand, well, the tumour is only part of the story. What genes was that child born with? That's also important. Can we bring information from that in to better treat the cancer as well, and I think more and more we are seeing that that's the case, that looking together in a holistic way at what a child is born with, what is going on in their tumour and how we can target both aspects of that is the way to the best outcomes.
Sarah Sedghi: Researchers like Dr Mark Pinese have high hopes of what precision medicine can do for those born with cancer risks. For some people it might mean knowing what drug to give them that will respond well to the mutation they have, to either treat a cancer or stop it forming in the first place. For others it could mean that preventative surgery, like some women with BRCA1 and BRCA2 mutations, for whom a preventative mastectomy and removal of their ovaries can reduce the chances of breast and ovarian cancer developing by up to 95%. Whatever the age of the patient or the cancer type, treatment would be targeted and personalised. For children with cancer, it would be an enormous leap in how things are done. Currently treatment for childhood cancer is often harsh and unspecific because much of the research on treatments to date has been done on adults.
Mark Pinese: Very sadly, many children who survive cancer do so with long-term side-effects. These can be lifelong effects on their fertility, on their growth and development, on their learning. And we are as much as possible trying to minimise that and we honestly are finding that if we can find targeted treatments, we believe that that will minimise side-effects as well.
Sarah Sedghi: Another tool being used for people at high risk of cancer from inherited mutations is surveillance, that's following up people to see if there has been a re-occurrence or a new cancer that has developed that could be treated early. But it's a double-edged sword.
Mark Pinese: We started that program a number of years ago, and at this stage it's proven to be a very successful program in which we have been able to pick up a number of diagnoses at a very early stage, and I think we are very confident that that has made a big difference.
Anna Murphy: In cancer land we tend to call it scanxiety, but we have to think of it as a blessing that we know about it.
Sarah Sedghi: Across multiple states in Australia right now, a clinical trial known as SMOC is being run. It's using MRIs and other surveillance for people at high risk of developing cancer, particularly multiple types of cancer like those with Li-Fraumeni Syndrome. Professor Paul James is a clinical geneticist and the director of the Familial Cancer Centre at the Peter MacCallum Cancer Centre and Royal Melbourne Hospital.
Paul James: In the past, people have always looked at Li-Fraumeni Syndrome as a situation where the risk was very high but there wasn't an awful lot that we could do about it because it was a complex risk that involved lots of different types of cancer. But this trial has really showed that actually there is a lot more that we could do and if we take a very active approach we can actually make a difference, even in a condition that has such a high risk as Li-Fraumeni Syndrome.
Sarah Sedghi: There used to be view in medicine that knowing these genetic risks was often futile because not enough was known about how to prevent or treat associated cancers. But Professor James says that's shifting, and he is optimistic about where precision medicine is heading.
Paul James: In the past we just didn't have enough information or awareness of the people who were at risk in the population, and so there wasn't much we could do because it was really beyond us to identify that risk. Now we have the tools to identify it, I think that fatalistic view has really been replaced by a view that if we know who is at risk then there is much more that we can do and there's opportunities in every situation.
Sometimes the implications are quite confronting, but in comparison to simply saying, 'oh well, there's nothing we can do about it, some people will develop that cancer in childhood and that's just the way it goes', I think we have definitely moved on beyond that point and there's really no type of cancer where we would say we can't really tackle that, they are all situations now where if we have the right information and we understand the genetics, then there is definitely more we can do.
Anna Murphy: When I first found out, it was pretty hard to take, I was absolutely devastated when I found out that I actually had it because it's quite a rare mutation, and because I've already had cancer three times already, it was sort of like a real kick in the guts to me, like, wow, now I've got to worry about so many more cancers.
Sarah Sedghi: Anna Murphy lives with a mutation to the BAP1 gene. It's rare and puts her at risk of multiple cancers. Anna has already had cancer three times but none were related to her inherited BAP1 gene mutation.
Anna Murphy: I have got a son, he was only six years old when I was first diagnosed with cancer, and he's sort of lived through all three cancers with me, saw his mother sick and all the rest of it. And when I was diagnosed with this mutation I said my biggest fear was that my son was going to have it, and unfortunately he does have it. But like I said to him, we have to think of it as a blessing that we know about it and that we are both being tested for everything. I've got to be thankful that we know about it so that we are constantly being screened, so if something does turn up or reappears somewhere, it will be caught early.
Sarah Sedghi: Anna is part of the SMOC trial and has yearly full-body MRIs. If a cancer is there, the hope is it will be picked up and treated straight away. While she is grateful to be part of the trial, the constant threat of cancer weighs heavily on her.
Anna Murphy: Every time I have a scan, in cancer land we tend to call it scan anxiety. You know you've got a test coming up and you don't get results obviously straight away, so it's always there, it's always going to be there, that anxiety or just in the back of your head, like what if it has come back. I don't think it just ever goes away, just the constant fear of recurrence and that. It gets probably a little bit easier, but it just finds a way to still stay in there, don't worry.
Sarah Sedghi: How often do you think about cancer?
Anna Murphy: Oh wow, well, it sort of…I think it's there every day, it's like you look in the mirror and you see scars and you see scars from surgeries you've had or…I think it's something…I don't think I don't go a day without thinking of it, I think, to be honest. I think it's just part of me, as much as I don't want it to be part of me, it has just been such a big part of my life that it's not something I can just switch off. I can control it, it doesn't overwhelm me and things like that, but it's just something that you are reminded of every day when you look in the mirror.
Sarah Sedghi: You're listening to the Health Report on Radio National. This is a special feature on the genetics of cancer. I'm Sarah Sedghi.
Most cancers are acquired, brought about through damage to a person's cells, say from smoking, other toxins, or lifestyle issues. But these inherited mutations, while less common, can have devastating effects on generations of families. So how would you know if you're at risk?
Paul James: The standard way of thinking about identifying people who might have an increased risk based on a genetic cause is to think about family history, and that's still a very good guide.
Sarah Sedghi: As useful as knowing your family history is, Professor Paul James says it's only part of the picture.
Paul James: It only picks up about half of the people who carry an underlying gene mutation and that's just because some people don't know their family history, some people's families aren't that large, and so there's really not been much of a chance for a family history to occur, and in some cases these are cancers which, for instance the case of ovarian cancer and breast cancer, they are male or female specific, and so if it has come down from the other side of the family, so if you have a breast cancer gene coming down from the male side of the family, the family history may not be there.
Sarah Sedghi: The type of cancer and age of onset can also offer insight as to whether an inherited gene is behind it.
Paul James: And so these days we are also focusing a lot more on particular types of cancers, things like people who have a diagnosis at a young age, and those can also be really good clues about who we should be offering genetic testing to. And even there's a lot more interest now in offering this type of testing quite widely, maybe even as a screening test in the population, and there has been some good studies that have looked at how this would work if we were to offer the testing to everybody as part of a plan to work out the right recommendations for people in terms of screening and follow-up into the future. And so it maybe that as the genetic testing becomes more available, we can start to think beyond those standard risk factors like family history and age and start to think about using it for nearly everybody to work out your underlying cancer risk.
Sarah Sedghi: Learning you have an inherited mutation can be confronting. While some mutations may only raise your risk slightly, others mean the likelihood of cancer is very high. One of the essential sources of information, advice and support for those affected, is a genetic counsellor.
Laura Forrest: We talk about how they can manage those cancer risks, so for some people that might mean thinking about having risk reducing surgery. For other people it might mean attending regular cancer screening.
Sarah Sedghi: Dr Laura Forrest is a senior research fellow and genetic counsellor at the Peter MacCallum Cancer Centre. She has done extensive studies into people's experiences living with hereditary cancer risk.
Laura Forrest: Young people who have hereditary cancer syndromes will engage in cancer screening because it offers them a sense of control and it can offer them a sense of hope as well, some peace of mind over this threat that they may develop cancer. And we heard from our research that a lot of young people thought this is really their best shot at controlling their health with regard to this hereditary cancer syndrome. But some people also commented that on the flipside there is this real tension, they engage in this screening, but for some cancer syndromes, like Li-Fraumeni, they actually have no other options, it's screening or nothing. For some of them they actually felt that they had lost control because that was their only option and they couldn't choose anything else.
Sarah Sedghi: She also knows through her work as a genetic counsellor and through her research how difficult some decisions around cancer prevention can be, like for those women for whom a mastectomy will give them their best hope of stopping breast cancer.
Laura Forrest: They are huge surgeries and they really can't be underestimated. Young women who choose to have a bilateral prophylactic mastectomy tend to have very little tolerance for their cancer risk. So a lot of young women will choose to have this surgery because they just want to rule out breast cancer completely and they are willing to engage in this big surgery because they want to be there for their children, they talk about wanting to be alive for their children. Many of these young women, because their family histories are riddled with their previous female relatives who have gone on to develop breast cancer and often had really bad outcomes, they want to do everything within their power to not develop breast cancer because they want to be there for their children, they want to be there for their children growing up.
Sarah Sedghi: CDH1 is another hereditary mutation that puts people at risk of diffuse stomach cancer. It's not an easy cancer to pick up early, so those with the mutation may choose to have their stomach removed to prevent cancer. It's a life altering surgery.
Laura Forrest: Clinical guidelines recommend that young people have that surgery if they have a CDH1 gene change. They are recommended to have gastrectomy between the ages of 20 and 30 years of age. The consequences of the surgery can include things like it can really impact your body image, it impacts the way you eat, and of course food is so involved in how we socialise. It can have really far-reaching impacts, and yet people with the CDH1 gene change will still choose to have this surgery where they have their entire stomach removed, again, to make sure that they are there for their children, that they are alive for their children.
Sarah Sedghi: I mentioned earlier in this program that one of the goals of precision medicine for those who have inherited risk and go on to develop cancer is to find a drug or drug combination that their particular cancer will respond to. Professor Paul James says a phase 3 clinical trial known as OlympiA has had some of the most promising results for women with breast cancer.
Paul James: OlympiA was a very exciting result, it was looking at individuals with this type of breast cancer, triple negative breast cancer, and it was looking at the idea that an underlying gene mutation in BRCA1 or BRCA2 could help guide the treatment for those types of cancer, and the outcome was very successful. They were trialling a drug called Olaparib which is a targeted therapy which is designed to expose a vulnerability in the cancer which occurs because it has an underlying gene mutation in BRCA1 or BRCA2, and what they showed is if that genetic fault was there in the gene in either an inherited form or if it even had just occurred in the cancer itself, then Olaparib was a very successful treatment and was amongst the most successful trials that there has been in the last few years for breast cancer, so a very exciting result and one which is likely to have a big impact on the way that breast cancer management is done in the future. And that's a good example of how important this genetic information is becoming, not just for the traditional reason of trying to identify individuals at high risk but also even once diagnosis occurs, increasingly the genetic information plays a big role in working out what is the best treatment for that person and targeting specific aspects of their cancer. That's an area that is advancing very quickly and is likely to apply to more and more genes into the future.
Sarah Sedghi: The discovery of the BRCA1 and BRCA2 gene mutations more than two decades ago was just the start, Professor James says. As more genes have been discovered, more possibilities for treatment and prevention have followed. But precision medicine is really still only in its infancy. There's still much to learn.
Paul James: There's nothing more personal to you than your own genetic make-up, and everybody's genetic make-up is unique, and using that information to work out in what way your own requirements in terms of both preventative measures, things to reduce your risk of cancer, and then if you have a diagnosis, in what way your genetics informs the best treatment for you, that's really a key part of the idea of targeted therapies or targeted screening programs that are actually designed or tailored towards exactly what you need based on your underlying genetics.
And so you'd hear a lot about personalised programs that include a number of different elements, but genetics or genomics which is looking more broadly at every variation right across your genome, those are things which are really core to the idea of personalisation and precision medicine.
Sarah Sedghi: Right now much of what is known about hereditary risk focuses on single gene mutations. Professor Paul James says researchers are also turning their attention to how multiple genes interact with each other.
Paul James: Just at the moment we are at the point where we are starting to really think about even more complex genetic risks, so instead of the risk being due to one large genetic fault that occurs in a single gene, we are starting to think about the way that genetic variations across the genome start to interact with each other and can cause their risk by being added up together, so a compound effect where all the different genetic variants actually come together to produce the risk, so it's not any one variant that's important now, it's the burden of different variants that come together to cause the risk. And that's a type of testing that would allow us to really offer genetic testing to anybody and provide an assessment of their risk, and that's known as polygenic risk, and that's just starting to come through now as something that we are beginning to be able to look at, at least in the research setting. And so we've got a number of trials looking at both risk prevention for high risk genes but also now whether or not polygenic risk can also contribute to those types of risk assessment processes and improve our ability to identify the people that we want to offer more targeted screening or targeted risk prevention to.
Michelle Brady: People living under the cloud of Li-Fraumeni, it's a tough life I would say. It's hard for me to say what their lives are like, but I can imagine that living in…and I know many of the families don't live in fear but it's an umbrella that they live under, you know, the constant worry if a little lump comes up on their hand or they start feeling a pain in a certain part of their body. It's a constant worry in the back of their heads, it's a constant life of being tested, MRIs, dealing with treatments, dealing with the next cancer coming along. And to live with that constantly, I can imagine, it can be quite dark at times and challenging.
Sarah Sedghi: Michelle Brady continues her daughter Addie's legacy by supporting families and research into hereditary cancer syndromes like LFS.
Michelle Brady: If I can help families going through it, then that's only something positive that can come from losing someone like Addie because she had, like I said, such zest for life, and I know for me going forward…a lot of people say to me how do you cope, you know, how do you do this, why do you do this? And I do it because of Addie, simply because of that, because I know that she wouldn't want me to carry on through life just mourning her death, she'd want me to do something because of what happened to her. So if that's helping us supporting other families, then that's surely only a good thing.
Sarah Sedghi: This has been the Health Report, I'm Sarah Sedghi. Norman Swan and Tegan Taylor will be back with you at the same time next week.
More than two decades ago a major milestone in cancer research was reached with the discovery of the BRCA1 and BRCA2 genes. Inherited mutations to these genes can dramatically increase the risk of developing breast and ovarian cancers. The discovery opened up new ways of knowing who is at risk of cancer, how to treat the cancer, and even how to prevent it happening in the first place. Since then many more inherited gene mutations have been found, that are linked to other types of cancer. This moving feature describes what this genetic information means for families who have seen loved ones endure sometimes multiple cancers—and it explains the emerging frontier in medicine trying to change that.
A/Prof Paul James, Clinical Geneticist and Director, Familial Cancer Centre, Peter MacCallum Cancer Centre and Royal Melbourne Hospital
Dr Laura Forrest, Senior Research Fellow and Genetic Counsellor, Peter MacCallum Cancer Centre
Host: Dr Norman Swan
Interviewer and Producer: Sarah Sedghi


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I was literally – almost asleep – when it hit me.
Tomorrow is the 21st.
So here I am, barely awake, the glow of the computer screen the only light in the room, casting its ghostly hues upon my fingers as they dance across the keyboard.
It’s cold, really cold, and I want to curl back under my microfiber blankets – but what if the Mayans were right? What if the world does end tomorrow?
This then, is my last opportunity to say thank you.
Thank you to my beautiful mare who makes every day different, and whose soft nuzzling and welcoming whinny makes my heart smile. Thank you to my cute little mutt who, at this very moment, is curled up on my bed wondering where I am and why I left. Thank you to the man who made my toes curl and taught me the truth – the real truth – of my submissive soul. Thank you to every one of you who has been kind enough to read my musings and my books and post comments. Thank you to those of you whose blogs have shown me that I am not alone – that the craving ache I feel every minute of every day is shared by so many.
When I think of all the blessings in my life, it is truly impossible to say thank enough times, or cover the multitude of those things for which I am so grateful, and about which I could be writing.
I hope we will be here on the 22nd, and in the light of that day I might even feel foolish having done this.
But one of the things I have learned through my little life, is to expect the unexpected.
Until next time – hopefully ….


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A chance to swag a fast and fabulous comedy caper hailed the funniest show in the West End.
The hit West End farce will air over the festive period.
Calamity is guaranteed in a surefire farce from the Mischief Theatre Theatre Company.
From The Play That Goes Wrong to Peter Pan Goes Wrong. What can go wrong?
The Play That Goes Wrong to be unleashed north of the border.
We find out about the hit farce The Play That Goes Wrong, now at Trafalgar Studios.
Mischief Theatre’s delightful comedy farce to run at Trafalgar Studios.
Hilarious physical comedy piece from Mischief Theatre.
New farce from Mischief Theatre.


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Refer to: https://aws.amazon.com/blogs/security/securing-access-to-aws-using-mfa-part-3
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Egyptian Exports To Thailand Dive To $40 mln In 2012
Published Monday, 04 February 2013 13:03 |
In 2012, the Egyptian exports to the Thai markets declined on account of exiting some Thai industrial investments from Egypt after the Egyptian revolution; recording $ 40 million in return for $ 50 million in 2010 and 2011.
Mr. Ali El Korey, Chairman of the Egyptian-Thai Business Council, said the trade exchange between the two countries recorded $ 650 million; elucidating that the volume of the Thai investments in the Egyptian market became tenuous after the revolution due to the lawlessness.
El Korey added to "Amwal Al Ghad" that some Thai businessmen withdrew and froze their activities in Egypt since the revolution has erupted owing to the political instability; calling for using clear mechanisms for restoring security and reaching consensus in Egypt's political street to attract several investments.
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SALE United continued its blistering start to the Gippsland Soccer League season with a 6-0 win over Fortuna.
Sunday’s win at Morwell followed the Swans’ 5-0 round one win over Traralgon City.
The victory put the Swans in third place on goal difference behind leader Moe United and Falcons.
Three goals in the first half was mirrored by three more in the second.
Captain Ash Ross scored two goals to go with his goal from the previous week, while Tommy Nguyen opened his season account with two. Jacob Patterson scored his second goal in as many weeks, while Graham Young also scored.
MOE United maintained its unbeaten start to the season with a 2-0 away win over rival Churchill United.
Ash Birrell, coming off a hat-trick, and Sam Gatpan scored for the Red Devils, who have scored 15 goals in just two matches.
The loss ended any hopes the Rams had of a second consecutive undefeated season.
AFTER winnings its debut match, East Gippsland United came back to earth with a 7-1 loss at home to Falcons.
Transitional play between Tom D’Alia, Jesse Kennedy and Sam Amaira saw the latter tap home to give the visitors the lead.
Kennedy doubled the lead from a free kick and further goals from Amaira and an own goal would put the result beyond doubt by half-time.
There was no let up from Falcons in the second half as Amaira completed his hat-trick along with another own goal and goal to Isaac Abas.
East Gippsland continued to grind away and was rewarded with a goal from a stunning free kick in the top corner by Jaydon Steele.
MONASH overcame a slow start to defeat Trafalgar Victory 5-1 away.
The home side applied pressure on the young Monash side early, which it turned into a 1-0 lead 15 minutes in. The Monash defence was left appealing for an offside flag after Sam Jones ran through on goal unopposed to score.
Trafalgar seemed content to defend its lead and repelled Monash attacks stoutly. Its hard work was undone minutes before the break as Brendan Ruddell powered home a free kick from 20 yards out.
Monash came out a different team after the break with former coach Wally Noppert given space outside the box to rifle into the top corner with his left foot in the 49th minute.
Four minutes later Noppert was again given space, this time firing home with his right foot. The introduction of Ty Christy off the bench gave the Wolves extra attacking threat and he was involved soon after his introduction in the build up as Ethan Lawrence extended the lead midway through the half.
It threatened to become a rout as Noppert crossed to Marcus Krznaric minutes later to make it 5-1.
Despite its probing Monash was unable to add to the scoreline with 16-year-old midfielder Chris Oulton seeing his effort ruled out in what would’ve capped off a stellar debut.
OLYMPIANS piled more misery on Tyers, defeating home side 11-1.
In two matches, the Lightning has already conceded 24 goals.
Aaron Daniel scored three goals, Chris Panayiotou and Heydan Cook two each, with one each from Eamon Stuart Suares, Jamie Pistrin, Simon Ierardi and Liam Antonelli.
Dylan Cramer scored for the hapless Lightning.
AFTER a round one bye, Newborough-Yallourn United began its campaign with a 1-0 win over Morwell Pegasus at home. Andrew Batt scored the decisive goal in the first half.
TRARALGON City had the bye.
SALE United will again be away from home this Sunday, when it will meet bottom-placed Tyers side.
Top side Moe will host fifth-placed Monash, with the clubs playing for the Fred Gauci Trophy. Monash has held the trophy, contested across all the divisions, for the past five years.
In a battle of undefeated teams, Falcons will meet Newborough-Yallourn.
Olympians will host Churchill, which will be looking to bounce back from its loss to Moe.
Two matches will be between sides which lost last week, with Pegasus hosting Traralgon City and East Gippsland will host Trafalgar in the battle of the new boys.

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Swiss banking, known for its secrecy, gets put in the spotlight
Hi there! Dan DeFrancesco in NYC.
Today, we've got stories on how much blame Federal regulators deserve for SVB's downfall, advice for being a better middle manager, and some tips for Costco shoppers.
But first, what the hell is going on?
1. Swiss banking shakeup.
Swiss banking, for better or for worse, has always been known for one thing: discretion.
But now the country that prides itself on keeping secrets is having its dirty laundry aired.
UBS begrudgingly agreeing to acquire rival Credit Suisse has put Swiss banking on center stage. The news even usurped the financial drama continuing in the US, whether it be the continued fallout from SVB or the fate of First Republic Bank.
Credit Suisse has stumbled through its fair share of crises in recent years. But the fall of SVB seemed to be too big a hurdle to clear, as questions began to mount about its financial situation. You know it's bad when your biggest shareholder essentially throws up its hands.
So where do we go from here?
Even those within Credit Suisse don't quite know that answer. Insider's Kate Duffy, Lina Batarags, Huileng Tan, and Nidhi Pandurangi report on the mood in Europe and Asia.
Perhaps this quote from a current Credit Suisse employee sums things up best.
"The vibe was very much 'this is very rushed, nobody has a clue what happens next, it's basically up to UBS but sit tight'."
Meanwhile, Insider's Carter Johnson, Casey Sullivan, Dakin Campbell, Alex Morrell, Rebecca Ungarino, and Emmalyse Brownstein have a report on how Credit Suisse's investment bank employees are feeling. In addition to breaking down the news, we've got the rundown on the winners and losers from the deal.
And while lots remains up in the air, one thing is certain.
Credit Suisse told staff they'll still receive their bonuses.
In other news:
2. So how bad is this gonna get? Regulatory-led bank takeovers in Switzerland. First Republic Bank looking for help. Central banks telling everyone to remain calm. Is this the beginning of the end? Here's a rundown on how bad this banking crisis could be.
3. The Fed blew it! A New York Times report details how officials at the Federal Reserve identified red flags at Silicon Valley Bank as far back as 2021. Read more about why regulators might deserve some of the blame for the fall of SVB.
4. Reading between the lines of the UBS-Credit Suisse deal announcements. Lost amid the frantic takeover were the passive-aggressive digs both banks took at each other in their statements announcing the news. More on both sides subtly complaining about the deal nobody wanted.
5. Inside a $12 billion startup's rapid ascent. HR startup Deel took off during the pandemic as companies grappled with how to recruit and hire workers around the globe. The startup grew from fewer than 30 employees to more than 2,000 workers in three years. But it didn't come without its hurdles.
6. That random friend request could end up costing you. Romance scams are big business, as digital grifters bilk about $1.3 billion a year out of people looking for some companionship. More on the rise of romance scams on the internet.
7. But what about the neobanks? The sale of Credit Suisse for $3.2 billion begs the question: What the hell are neobanks worth? If a long-established, albeit beleaguered, investment bank was sold at such a discount, then what could a digital-only consumer bank really go for? Read more here.
8. How to not be one of those managers. Matthew Meade, who spent more than 15 years working in finance at firms like JPMorgan and Bank of America, shares tips on how to excel at being a middle manager. First up, avoid these five mistakes mid-level managers tend to make.
9. Don't do this at Costco. If you're a member of the exclusive club, don't do this next time you shop there. From the type of membership you should get to the hidden meaning behind prices, here's some advice for all Costco shoppers.
10. Never leave home without it. You learn a lot when you've been to 40 different countries, including 22 on your own. These are the nine things you should always bring with you when you're traveling solo.
Curated by Dan DeFrancesco in New York. Feedback or tips? Email email@example.com, tweet @dandefrancesco, or connect on LinkedIn. Edited by Jeffrey Cane (tweet @jeffrey_cane) in New York and Hallam Bullock (tweet @hallam_bullock) in London.
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Donte Wilkins is carrying his 295 pounds more nimbly these days. His weight is unchanged from last season, but his body fat has dropped to 15 percent, from 22 a year ago.
The load Wilkins is shouldering for the Virginia defense, meanwhile, has gotten considerably heavier. A reserve defensive tackle last season, Wilkins is at the literal and figurative center of the scheme this season, the nose tackle in the Cavaliers' new 3-4 alignment.
"When you have a 3-4 defense, the nose tackle is, if not the Most Valuable Player, certainly one of the most valuable players on your entire team," coach Bronco Mendenhall said. "Donte just happened to be here, hungry for an opportunity, and physically and mentally ready for that opportunity to match our system."
A senior from Woodbridge, the affable Wilkins has been in the mix in the trenches for three seasons. He played in nine games as a true freshman, starting three. He started five games in 2014 but saw limited action behind defensive tackles David Dean and Kwontie Moore last year.
When Mendenhall replaced Mike London after the season, Wilkins was hopeful the new coach would implement the 3-4 scheme he used at Brigham Young. He had played some nose tackle in high school and saw it as an opportunity for a fresh start.
"I'm liking it," he said. "It's a lot more responsibility, but it's a lot more fun, too."
Wilkins is the anchor of a line that features Oscar Smith graduate Andrew Brown and redshirt freshman Eli Hanback at the ends. Brown and Hanback also are converted tackles.
They'll be on display today, when Virginia holds its version of a spring game – a final practice at 4:15 p.m. that will include a scrimmage, which is open to the public.
Overseeing the unit is veteran coach Ruffin McNeill, who was reassigned before spring practice after Mendenhall decided the line needed more attention. The former East Carolina head coach has brought his trademark brand of tough love. His booming voice stands out at practice.
"His nickname is 'The POD:' the prince of darkness," Wilkins said. "It's go time when we get on the field; he preaches that to us every time that he we have to be nasty."
The linemen say they're welcoming the reinvention. Brown, a five-star recruit, struggled through an injury-plagued freshman year and didn't crack the rotation until late last season. He finished with six tackles.
On a thin and inexperienced line, he'll be counted on to be more productive this year.
"I know the ability he has," McNeill said . "He really has come out every day with a 'coach me' attitude, and he wants to be a really special player.
"He's got athleticism, he has quickness and I think he has the playmaking ability. If he can master the system, then we have some ways to take advantage of his athleticism too."
The 6-foot-4 Brown also sports a leaner look, although carrying the same 280 pounds he did last season. Like Wilkins, he's excited about a fresh start.
"The 4-3 you just attack, attack attack," he said. "But the 3-4, you've got to use your eyes, use your hands, react to the offensive linemen and what they're doing."
Instead of getting upfield quickly in their assigned gap, linemen are now responsible for controlling the gaps on either side of the player in front of them. The "read-and-react" style is similar to the one employed for years when Al Groh coached Virginia.
McNeill adds a twist, with his emphasis on linemen fending off blocks with "violent" hands.
"I love him," Brown said. "He's very motivational. He's definitely hard on us, but the thing is, we need that. Something we haven't had in a long time is a true discipline factor, and an organized factor as well."
Brown has been lining up on the left side, with Hanback, a 6-4, 280-pounder, on the right. If Wilkins and Brown were known quantities, Hanback has been more of a surprise.
"He's ahead of schedule," McNeill said. "Really fundamentally sound and smart; uses his hands well. Still has some footwork to work on and needs to add upper-body strength, but I think he'll be one of those guys ... he'll make some noise here."
Wilkins has been making his share in the spring, controlling the interior. With dreadlocks spilling from his helmet and his compact 6-1 physique, he's hard to miss in the middle.
Mendenhall said Wilkins has had an "exceptional" spring. For the 3-4 to thrive, he'll need to continue at that level.
"I would love to have five, six more defensive linemen just like him," Mendenhall said. "He's really kind of setting the standard for what we'd be looking for in the future at that spot."
Ed Miller, 757-446-2372, email@example.com Follow @edmillervp on Twitter.


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Folk Stephen Carradini
Remarkable consistency marks “Break in the Clouds” from Colorado-by-way-of-Tahlequah folksters Elephant Revival. Although the album is 14 songs long, there’s not a bad tune in the bunch.
CFN Gazette staff
Someone must have dumped a love potion into the water at the Oklahoma
City Zoo and Botanical Garden. On Sept. 26, the zoo welcomed a newborn
giraffe — who doesn’t have a name yet — into the world.


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One concerning factor that has always being nagging in the back of my mind is what happens when your keywords value constantly diminishes over the life of a campaign?
Typically clients are pushing for improved ROI from their digital campaigns so what happens when their primary keywords are tracking the opposite direction and ROI is falling?
I took a snapshot of AdWords (search only) data and decided it was time to research more about the concept of diminishing value and did it exist? For this post analysis the data that was analysed consisted of 22,354 clicks over 2.5 years but was just based on their single highest traffic keyword.Â
I picked a single keyword to speed analysis and standardise the data set as many keywords did not run consistently or have enough clicks.
Also unlike several of their other keywords I could have used I found they focused on this keyword with a significant daily budget to ensure it was showing most hours of the day.
Also I used AdWords data as the shift in ROI seems far clearer cut in PPC than SEO, but also its data is more consistent as AdWords offers much more control over max bids, total budget and landing page optimisation.Â
The first insight to notice was that the average CPC showed a 48% increase in cost during that time, this was not a problem for this particular client as their campaigns spend grew at 400% during that same period of time.Â
What were some of the increases in campaign cost?
- Non-competitors expanded business modelÂ to directly compete
- More offline/online competitors piled into PPC campaigns
- Existing competitors got smarter with their PPC campaigns
- Overall the vertical got far more competitive as target market shifted online
But what about if they were not able to increase the campaign spend as rapidly to cover the increase in average CPC rates, would they have to stop advertising? There are often a number of businesses that operate on the arbitrage model and cannot afford such a large reduction in their margins per visitor.Â
How Does Rise Track with Budget?
Rise in average CPC tracks almost perfectly tracks the growth in campaign budgets over 2.5 years, which is concerning unless you can continue to increase your PPC budgets you may struggle to continue to expand your digital channels.Â
It also shows how Google is manipulating the actual cost of AdWords traffic consistently overtime, so you need to ensure your conversion rates continue to improve to counter the diminishing value of visitors.
There is also a time when you have to stop focusing on a particular keyword because it’s either become too competitive to be cost effective or user behaviour has shifted so much around that term that it’s no longer a commercially viable keyword.
What About Falling Interest?
One external factor that is out of your control is as your audience adapts and becomes more educated about your products is the shift in what keywords people are using.Â It also appears as consumers mature there is also the increasing number of online brands that are stealing away traffic from generic search terms.Â
One interesting point to explore in more detail would be the shift of search terms towards local language alternatives and more niche searches.Â
A lot of this shift in search behaviour is driven by display advertising and offline advertising that you may not always have as much control over.
One of the key target terms for travel affiliates, airlines and travel agents is “cheap flights” but you can see the search volumes are dropping over the past 8 years.Â
Looking at the keywords that are now driving traffic it appears that the search terms are fragmenting and the rising search terms are mostly focused around branded searches for airlines know for cheap flights such as Southwest & EasyJet.Â
One of the key target terms for banks and financial affiliates is “credit cards” but you can see that its traffic has also fallen as a key search term over time, but “credit card” has increased slightly.Â
This could be easily assumed that consumer spending patterns have changed and they now look for single credit cards rather than multiple cards, along with rises in searches for “prepaid credit cards”.
The keyword “travel” is another massive vanity term for any travel agency, travel affiliate, travel guide, travel blogs but you can see that consumers have adapted their behaviour are not just typing travel into Google as much anymore.Â
There is a shift in travel search terms to be more focused around travel brands, travel portals and travel information as consumers become more specific about their search intentions.
Are you still focused on a single keyword?
The key message is to understand how your single keyword strategy maybe starting to fail you as consumers adapt their search behaviours and brands continue to steal away more generic search traffic.Â
If you are relying on a single keyword to drive a majority of your sales/traffic you are putting excessive risk both around over optimisations of that keyword but also risk dying out like the dinosaurs.
Just on that point of online brands taking more and more generic keywords out of the realms of and SEO for that gerneric term.
So should companies be rushing to trademark as many niches as possible to broadend their footprint and stomp on compeditors?
I would say companies should be looking to build out content so they are known for more than one thing. If you are a website that focuses on cheap flights, why not have content around how to get cheap flights, when is cheapest to travel… also have an email list of people who look for cheap flights and market to them so you rely less or Google organic traffic.
Sure if you have the resources to expand your brand to have a broad but focused footprint that can also work but many players don’t have that long term view/focus.
You can’t use Google Insights for Search to draw conclusions about how the *absolute volume* of searches for a keyword is changing over time because the graphs are based on data that has been normalized (against total search volume) and scaled.
A downward slope for a keyword like “credit cards” could mean that “as a percentage of all queries on Google,” the fraction is declining over time (say from 0.01% to 0.0075% of all queries). At the same time, the total volume of searches for a keyword might actually be increasing (because total searches on Google increased say by 40% from one period to the next).
For some additional detail about this, please read:
Disclaimer: I work at Google in AdWords marketing.
I think it’s pretty much common sense that the value of PPC (and SEO) will diminish in the coming years as more marketers enter the game (unsophisticated marketers will accelerate the decline!). PPC and SEO are just like anything else – to maximize your ROI on an ongoing basis, you have to accurately track your results and continually test new (niche) strategies (within PPC and SEO or new forms of marketing). Once the herd catches on, the value/return plummets.
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domain: economics


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Arsenal legend Thierry Henry has predicted that the north London side will struggle to qualify for Europe based on their Monday night performance against Crystal Palace. And supporters agree with their former striker.
Speaking as a pundit on CBS Sport’s UEFA Champions League coverage last night via the Mirror, Henry was asked if he believes Arsenal will qualify for Europe next season.
The Gunners failed to qualify for Europe last season for the first time in 26 years as Arsenal finished eighth in the Premier League standings with no silverware.
And this season could well be another year where Arsenal fail to qualify for any sort of continental football. The north London side have had a mixed bag of results, and their performance against Palace was poor.
And for Henry, more performances like that could see Arsenal fail to reach Europe again. When asked if his former side could qualify, the retired attacker said: ‘”Not with what I saw recently.”
Indeed, the striker’s comment was a damning statement to how the Gunners operate under Mikel Arteta. Arsenal have a mountain to climb, and results have to improve soon.
Arsenal fans agree with Henry’s Europe prediction
With Henry giving his verdict, some Arsenal fans on social media agree with what the French legend had to say on the Gunners chances of finishing in a European spot this season.
Here’s what some Arsenal fans had to say about Henry’s comments on Twitter…
He ain't lying we look and play like a bottom half team…and it hurts me saying that as passionate supporter of the club… https://t.co/gl1vtD6R6N— fuad el arabi (@fuad_el_arabi) October 20, 2021
he's right https://t.co/pcRilWSCrZ— Nizan⚡🎃 (@afcniz) October 20, 2021
Henry a real one https://t.co/nBaGotD9s3— colonel (@ColonelG45) October 20, 2021
I agree. https://t.co/411vk6Veoa— MBurgess 1886🏴🇲🇽 (@_BurgessP) October 20, 2021
This team would be lucky to get top 10 never mind European football https://t.co/WtlSiJHLD8— C h r i s t i a n 🇨🇩 🇿🇦 (@Ben_Jnr_) October 20, 2021

domain: sports


The Pentagon must continue to tweak its weapons mix if it wants to meet the military challenges of this century, a member of an influential think tank told an audience of field grade (and at least one general) Air Force officers today.
Discussing the Center for Strategic and Budgetary Analysis new operating concept for dealing with an increasingly well-armed Iran at the Air Force Association's headquarters, CSBA's Mark Gunzinger said the Pentagon needs to buy more survivable long-range strike and ISR gear while trimming spending on weapons that may not be in high-demand in the coming years.
Citing the increasing numbers of countries such as China and, specifically Iran that are building their abilities to strike enemy bases and aircraft carriers near their borders Gunzinger asked:
What are the implications if we don't have close-in bases? Obviously, our shorter range capabilities will have a great challenge to overcome, and we're not just talking about land-based, we're talking about sea-based. What if our carriers can't get within 300 nautical miles, 400 nautical miles of Iran in the future? If they're equipped with short-range fighters, F-35C, they're not going to have a lot of coverage inside Iran."As I've said before, CSBA's ideas and recommendations frequently tie in closely with what becomes Pentagon strategy and policy, so it's always a good idea to pay attention to what the K Street-based think tank is saying.
Given that CSBA's ideas of Air Sea Battle -- which its Iranian concept is based -- call for long-range penetrating strikes that take out heavily defended command, control and ISR infrastructure -- a "kill the archer not the arrows" approach, as one of Gunzinger's slides read -- small, slow and unstealthy weapons will have less use on the modern battlefield than they have over the last three decades. He then listed the categories where the Air Force, Navy and ground forces can invest in:
I haven't got any argument's as we've briefed this about the fact that we need to adjust our mix of long-range and short-range capabilities, and I'm not just talking about the mix of fighters and bombers, I'm also talking about UAVs. We need to take a hard look at our UAV force. The majority of our UAVs are optimized for what? Operating in very permissive environments, they're not stealthy and a lot of them don't have great range and that's a part of the mix we might want to adjust to our more sophisticated and advanced unmanned capabilities with greater stealth.He went on to suggest that the ground forces invest more money in long range weapons like MGM-140 ATACMS and directed energy missile defense and that the Navy seek to buy Virginia class submarines modified to carry a large number of Tomahawk cruise missiles to replace the aging Ohio class guided missile submarines.
He then moved on to discussing where the Pentagon should do more trimming before circling back to where the DoD should invest:
We simply can't continue to throw money at problems and hope to solve them that way because the money's not going to be there. One of the main reasons why the U.S. military developed new concepts like Air Sea Battle and Outside In, is to provide new lenses to take a look at challenges and what the capabilities are that we need to address those challenges, not just prime capability gaps but where we may have invested too much or where need to accept more risk, and there are some areas where we would all agree we might want to do that in the future in order to resource higher priority capabilities.


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We reported several weeks ago that on December 3rd, Tazewell County, VA voted their county a Second Amendment Sanctuary.
But we also told you how they did something unique: they simultaneously ordered themselves a militia.
Since then, media outlets and even officials from other counties have been knocking at their door. The media is looking for a story. The other counties are curious if they could follow suit and are asking what this militia looks like. As the questions have poured in, county officials have replied with a standard answer:
On Dec. 3rd, 2019, our Board of Supervisors chose to exercise some of its rights under the Virginia Constitution to order or regulate militia. By insuring that our residents have the opportunity (1) to possess certain types of firearms, (2) to educate themselves on their use, (3) to learn common military practices, and (4) to learn basic survival skills, we hope to preserve a group of residents who could form a militia, were such a body needed. Without these most basic elements our County would not have a group of persons from whom a militia could be drawn. At the moment, however, the Board has not called any such militia to arms and prays that such moment never occurs.”
In plain English, they’re saying, “We don’t want to call the citizens to arms against the Governor, but we can and we will if pushed. Also, we are keeping our “assault weapons.”
If Push Comes to Shove…
You see, if each member of the public is a member of the militia—and they have been so ordered by the county’s declaration in December—then as members of the rightly called militia, they have rights.
Those rights include the right to own certain types of firearms. Namely, the right to own semi-automatic and “assault rifles.” So whatever laws might come out of Richmond banning assault weapons, they wouldn’t apply to militia members—aka, everybody not already prohibited from owning a gun—in Tazewell County.
And they’re not blowing smoke about the threat to their guns. SB16 is a Senate Bill that was already filed and would do just that: ban ownership of all semi-automatic rifles. Even ones you already own legally and purchased legally and have owned for years without any crime committed.
Let’s Get On Board That Train
Needless to say, other counties like this idea.
Local news media reported that a large crowd gathered outside the courthouse in Wythe County, asking their Board of Supervisors to pass a militia ordinance there, too. The Tazewell County declaration was being passed around the crowd. In Buchanan County, the Supervisors are waiting for the installation of new board members to vote on sending a letter to Gov. Northam demanding his resignation. They also plan to vote on a militia resolution at the same time.
Some People are Slow on the Uptake
Northam, you don’t play chicken with boys from Virginia. This is a lesson you should’ve learned that in the schoolyard growing up. You didn’t, so it looks like you’re going to have to learn it now.

domain: sociology


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- Brand: Solgar
- Product Code: chromium-picolinate-trivalent-500-mcg-SLG
- Servings per Container: 120
- Quantity per Container: 120 Veg Capsules
Chromium Picolinate (Trivalent) 500mcg from Solgar is a vegetarian mineral supplement that provides support for healthy blood glucose metabolism. This formulation contains trivalent, biologically active chromium.
- Trivalent elemental chromium
- Supports healthy blood glucose metabolism
- Suitable for vegetarians
- Made in the USA
Chromium is an essential trace mineral that plays an important role in helping insulin regulate blood glucose. Along with a nutritious diet, chromium may help maintain healthy blood glucose levels already within a normal range.
In addition, chromium is a component of a number of enzymes that release energy from cells and is required for proper receptor functioning necessary for nutrient metabolism.
1 vegetable capsule contains:
Chromium (as chromium picolinate) 500mcg (417%DV)
Other Ingredients: Microcrystalline Cellulose, Vegetable Cellulose, Vegetable Magnesium Stearate.
Contains NO: Gluten, Wheat, Dairy, Soy, Yeast, Sugar, Sodium, Artificial Flavor, Sweetener, Preservatives and Color.
Adults: As a dietary supplement for adults, take one (1) vegetable capsule daily, preferably at mealtime, or as directed by a healthcare practitioner.
Not intended for use by pregnant or nursing women. If you are taking any medication or have a medical condition, please consult your healthcare practitioner before taking any dietary supplement. Diabetics and Hypoglycemics, use only under a physicians supervision. Keep out of reach of children. Store in a cool, dry place. Do not use if outer bottle seal is missing, torn or damaged in any way.

domain: medical


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free Islandwide delivery when you spend over $250 Shop Now
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100% Italian Oil with our precious Summer Truffle.
Drizzle over meat and tartare, carpaccio and filets, pasta, eggs, cheese, salads, vegetables and potatoes.
Use as a finishing condiment, 1/2 tsp. per portion.

domain: food


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128 Results in category Bookkeeping
Over 8 years of CPA firm practice, owned tax and accounting business since 2003. Do all aspects of tax, accounting and business support of all types of entities. Specialize in small business, personal, tax resolution and IRS representation all States
Established in 2004, Shoreline Tax & Accounting Services is a tax and accounting firm providing assistance with a broad range of U.S. tax compliance to individuals and businesses. Located in DC, we are conveniently located in the Palisades.
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At Fix-It Accounting we have developed and refined strategic processes that enable us to provide accounting and tax solutions for our clients. Our team thoroughly reviews each case, prioritizes IRS compliance and ensures you don’t overpay on taxes.


The Samsung Galaxy GT-N8013 is a tablet device that boasts a large 10.1 inch screen, making it perfect for streaming videos, browsing the web, and playing games. It runs on the Android operating system and comes equipped with a powerful quad-core processor, ensuring smooth and speedy performance. With its built-in Wi-Fi and Bluetooth capabilities, users can easily connect to the internet and other devices. The tablet also features a front-facing camera for video calls and a rear-facing camera for capturing photos and videos. To protect the device's screen from scratches and cracks, our website offers a range of high-quality screen protectors designed specifically for the Samsung Galaxy GT-N8013.


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Big Management – New York , NY, United States 10010
Erika Jayne – Her SMASH hit “Stars” continues on it’s journey from dance clubs / dance chart/ dance radio to mainstream radio.
Visit Erika Jayne’s ReverbNation page at http://www.reverbnation.com/erikajayne1 and listen to her latest hit “Stars.”
Crystal Waters vs Speakerbox – “Dancefloor” exploding nationwide. Playing at WNYZ – The PULSE (NYC), KNRJ (Phoenix, AZ), DMX, MUSICCHOICE, The Original Hot 97 (NYC), iPartyradio (Chicago), AOL MUSIC, WMPH (Delaware), B91(NYC), PrideRadio (Los Angeles), Dancefactoryfm (Chicago), KNHC (Seattle).
Peter Presta feat. NOCERA – “Viva L’Amour” hits the Billboard Dance Club chart @ Breakout # 5
DOR DEKEL – “Boys of Freedom” Debuts @ #7 on IDJPOOL Dance Chart!
Christian George – “Strangers” Blowing up the UK Dance Clubs and Radio Shows “Opening my show with this track” – SCUMFROG
Dave Pezza – Releases his hit “It Came From Mars” on Trackworks Records
Fonseca vs Lane – After doing productions for Crystal Waters Anthony Fonseca (of Speakerbox) and Lauren Lane (NYC DJ @ PACHA, CIELO, MANSION) they hit the Dance scene with their own release titled “AfterParty” with some HOT remixes from the UK by LAVA, Warren Meyers, Liquid Nation, and from the U.S Rod Carrillo and Speakerbox.


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A Postcard from Wateringbury
A collection of re-printed Postcards from Wateringbury, a small village in the heart of Kent, England, UK. The photographs date from the early 1900's.
or create an account to post a comment.
Published March 24, 2011

domain: library


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Academic Press; 1st edition (Dec 15 2021)
Katja Pinker, Ritse Mann, Savannah Partridge
Breast MRI: State of the Art and Future Directions
Breast MRI: State of the Art and Future Directions provides a comprehensive overview of the current applications of breast MRI, including abbreviated MRI, as well as presenting technical recommendations, practical implementation and associated challenges in clinical routine. In addition, the book introduces novel MRI techniques, multimodality imaging, and advanced image processing coupled with AI, reviewing their potential for impeding and future clinical implementation. This book is a complete reference on state-of-the-art breast MRI methods suitable for MRI researchers, radiographers and clinicians.
Breast cancer is one of the leading causes of death among women with early detection being the key to improved prognosis and survival. Magnetic resonance imaging (MRI) of the breast is undisputedly the most sensitive imaging method to detect cancer, with a higher detection rate than mammography, digital breast tomosynthesis, and ultrasound.
- Spans the whole spectrum of breast MRI, including basic imaging techniques, indications, interpretation, and the latest cutting-edge techniques
- Reviews multiparametric MRI and abbreviated protocols, providing an outlook on the future of this technique
- Discusses the predictive and prognostic value of MRI as well as the evolving field of radiomics/genomics and AI


If the climate bill is passed, reports say that consumers will pay an extra $83 per year. That's 23 cents per day.
After some bluster early on, the Obama Administration seems to have turned away from green tech a bit. Earth Eats' Cory Barker rounds up recent developments.
This week has been full of ebbs and flows if you have been following the important climate bill making its way through Congress.


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Click on a thumbnail to go to Google Books.
Sharks (Usborne Beginners) (edition 2007)
by Catriona Clarke (Author)
Usborne Beginners: Sharks by Catriona Clarke
No current Talk conversations about this book.
What do sharks like to eat? Which shark glows in the dark? Why do some sharks never stop swimming? You'll find out the answers and lots more facts in 'Sharks'.
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