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Wisr Announces Five Pilot Partners
Wisr is very excited to announce a two-year development partnership with University of Chicago, Case Western Reserve University, Denison University, Oberlin College, and Cedarville University.
About the Partnership
Wisr vetted over 300 regional institutions to identify forward-thinking teams with the vision to build something truly unique and powerful for higher education. Development partners are required to assemble a cross functional team of career services, alumni relations, and advancement administrators and meet in-person for a quarterly advisory summit. Further, the project is intended to serve as a campus-wide platform to engage the entire student, alumni, and staff base. In exchange for the commitment, Wisr dedicated six months of product roadmap, prioritizing the feedback from its development partners. The Wisr Development Partners will be going live with their sandbox environment in October of 2016, and inviting Alumni and Students to the platform early in the New Year.
Overview of Partner Goals
While Case’s dual alumni communities are actively volunteering, they have lacked data-driven mechanism to match and facilitate advisory boards for individual students. Wisr will track the conversion of new alumni engagements and student activity as part of their pilot.
Oberlin has made a concerted effort over the last five years to overhaul their advancement division. They have a ready and willing group of alumni with unique careers, but need a scalable way to identify advisors for students of their unique liberal arts offerings.
The University of Chicago is currently under a $4.5 billion dollar capital campaign, with a goal of engaging 125,000 alumni in the next three years. Wisr will be used as a campaign vehicle for these strategic initiatives, while assisting career services in increasing internship and job opportunities for students.
Denison University President, Dr. Adam Weinberg, the Denison@Work initiative to help students fill the skills and confidence gap faced when making a transition from college to career. Wisr will allow Denison to track critical skills development through alumni advising and networking.
Cedarville is ramping up alumni engagement with new programming to leverage alumni to helps students moving to new parts of country for summer internships and jobs. Wisr will facilitate and measure new connections with alumni outside of the region.


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Hebrews 2:2-3; Hebrews 4:16; Hebrews 5:1; Hebrews 5:4; Hebrews 7:5; Hebrews 7:8-9; Hebrews 9:15; Hebrews 9:19; Hebrews 10:26; Hebrews 11:8; Hebrews 11:11; Hebrews 11:13; Hebrews 11:29; Hebrews 11:35-36
For if the word spoken by angels was stedfast, and every transgression and disobedience received a just recompence of reward;
How shall we escape , if we neglect so great salvation; which at the first began to be spoken by the Lord, and was confirmed unto us by them that heard him;
Let us therefore come boldly unto the throne of grace, that we may obtain mercy, and find grace to help in time of need.
For every high priest taken from among men is ordained for men in things pertaining to God, that he may offer both gifts and sacrifices for sins:
And no man taketh this honour unto himself, but he that is called of God, as was Aaron.
And verily they that are of the sons of Levi, who receive the office of the priesthood, have a commandment to take tithes of the people according to the law, that is , of their brethren, though they come out of the loins of Abraham:
And here men that die receive tithes; but there he receiveth them, of whom it is witnessed that he liveth .
And as I may so say , Levi also, who receiveth tithes, payed tithes in Abraham.
And for this cause he is the mediator of the new testament, that by means of death, for the redemption of the transgressions that were under the first testament, they which are called might receive the promise of eternal inheritance.
For when Moses had spoken every precept to all the people according to the law, he took the blood of calves and of goats, with water, and scarlet wool, and hyssop, and sprinkled both the book , and all the people,
For if we sin wilfully after that we have received the knowledge of the truth, there remaineth no more sacrifice for sins,
By faith Abraham, when he was called to go out into a place which he should after receive for an inheritance, obeyed ; and he went out , not knowing whither he went .
Through faith also Sara herself received strength to conceive seed, and was delivered of a child when she was past age , because she judged him faithful who had promised .
These all died in faith, not having received the promises, but having seen them afar off, and were persuaded of them, and embraced them, and confessed that they were strangers and pilgrims on the earth.
By faith they passed through the Red sea as by dry land: which the Egyptians assaying to do were drowned .
Women received their dead raised to life again : and others were tortured , not accepting deliverance; that they might obtain a better resurrection:
And others had trial of cruel mockings and scourgings, yea, moreover of bonds and imprisonment:

domain: literature


text: Our home is close to Lac de Vassiviere with beaches and Eymoutiers is only 5 minutes drive. Great area for cycling, walking and watersports. One double, one twin room and one family room all with en-suite shower room. Large garden, splash pool (after end May). Ideal for large or extended families and children. Set in rural hamlet close to 2 towns.

domain: travel


text:
Sep 25, 2009, 2:00 PM EDT
Prince Fielder receives a lot of criticism for his weight and the presumed lack of conditioning that comes with it, but as Adam McCalvy of MLB.com notes he’s the only player in baseball to appear in all of his team’s games this season.
Fielder has started at first base and batted cleanup in each of the Brewers’ first 153 games and plans to maintain his perfect attendance down the stretch:
Fielder recalled coming out of a Little League game when he was 12 years old, after fouling a pitch off his foot. “I came out of the game, and I remember someone being [upset]. They were like, ‘I think you’re all right,'” Fielder said. “That made me feel bad. I didn’t like the way I felt. So from then on, I wanted to play every day.
“I just felt soft. I didn’t like it. If I’m hurt, it’s one thing, but if I can to play, I want to play.” Fielder said he has fought through aches and pains this season, but never came close to asking for a day off. Manager Ken Macha never considered giving him one. “Not even close,” Macha said.
Interestingly, at least four players have appeared in 162 games every year since the strike-shortened 1994 and 1995 seasons, with a total of 76 different 162-game players during that 14-year stretch. And now suddenly Fielder is the only guy with a shot to do it this season. Coincidence or are teams more focused on giving their stars at least an occasional day off?
Fielder, incidentally, is hitting .297/.408/.595 with 42 homers, 34 doubles, 101 walks, and a league-leading 132 RBIs, including .282/.386/.600 with six homers and seven doubles in 23 games this month.
- Bryce Harper is naked in ESPN’s “Body Issue” 10
- Today is the day: Marlins ace Jose Fernandez returns from Tommy John surgery 3
- A-Rod, the Yankees and the union in talks to direct his $6 million home run bonus to charity 11
- And That Happened: Wednesday’s scores and highlights 37
- Video: Joey Butler breaks up Carlos Carrasco’s no-hitter with two outs in the ninth inning 12
- Bill Stoneman taking over as Angels’ interim GM 15
- Jerry Dipoto loses power struggle with Mike Scioscia, steps down as Angels general manager 36
- Bobby Bonilla’s isn’t the only deferred money deal in the game. And isn’t even the worst. 49
- With the same-sex marriage decision, the San Francisco Giants get another big win (276)
- Joe Maddon is the latest manager to rip instant replay. He’s got a point. (110)
- Settling the Scores: Sunday’s results (99)
- Report: Jerry Dipoto “definitely out” as Angels GM (77)
- And That Happened: Wednesday’s scores and highlights (75)

domain: news


text:
FlyingRC.net is a
Extreme Flight 78" Extra 300 – Update
The airframe remains more capable than I am
Text and photos by Tom Hintz
Flight video by Clark Ponthier
Posted – 6-12-2017
With several months of flying under my belt is has become clear that the Extreme Flight 78" Extra 300 has a level of capabilities that my piloting skill set is not likely to fully match. I think this is reality for all the RC pilots that are honest with themselves. The Extreme Flight 78" Extra 300 is just the latest airframe to highlight this disparity in talent.
Modern Airframe and Power Qualities
One thing that really stunned me when I returned to RC flying is the ARF (almost ready to fly) airframes available to us. Having so much of the construction done for us is great considering the hurried lives we lead today. Behind the pre-applied covering (done way better than I ever could) lies an airframe that is very well designed with ultra-precise, laser-cut parts assembled on super-accurate factory jigs. The Extreme Flight 78" Extra 300 is a product of that style of manufacturing that shows how exceptionally light, straight and durable airframes enhance their performance in the air.
I doubt the relatively new 3D segment of the RC world would be as prevalent as it is without these modern airframes. I am amazed at the loads such light airframes can withstand without blowing up in the sky. There will always be s smattering of in-flight failures but nearly all of them can be traced back to something the pilot/builder did rather than a deficiency in the airframe.
The Extreme Flight 78" Extra 300 takes advantage of the power and reliability of today’s gasoline-fueled engines by dramatically increasing the power to weight ratio that greatly expands its flight envelope. Just as important is that the designers and engineers at Extreme Flight understand how to make use of the power to produce such an aerobatic aircraft that is so easy to fly.
Though designed for 35cc engines the Extreme Flight 78" Extra 300 handles my DA50R very well. Low-speed flight remains surprisingly steady yet it runs straight and true at wide-open-throttle. Since its first flight the Extreme Flight 78" Extra 300 has sported a Mejzlik, 3-blade 20 by 12 carbon fiber prop that seems perfect for the job. Vertical performance is virtually unlimited yet there is enough load to keep the DA50R in a comfortable RPM range no matter which way the nose is aimed.
There are precious-few airframes that combine the “walking-speed” landings with such an extensive aerobatic capability. Knife-edge spins are a no-no for not-so-tough airframes but the Extreme Flight 78" Extra 300 cranks them out easily and comes back to Earth with all the parts it went up with. Now, hundreds of such spins later I am confident in the Extreme Flight 78" Extra 300 ability to do these things but truth-be-told, I am always watching for things to fall off. To date, nothing has been ejected or gives the impression it might depart because of these maneuvers.
The latest move I have been learning is the “crankshaft”. I have seen many videos of well-known 3D pilots doing crankshafts and making them look effortless. Over the last weekend I began learning to do the crankshaft maneuver. While the crankshaft itself is reputed to be very tough on airframes I suspect some of the attitudes I sent the Extreme Flight 78" Extra 300 into trying to figure out the crankshaft may have been even more aerodynamically stressful but it survived everything I threw at it.
Because the Extreme Flight 78" Extra 300 needs such low airspeeds to respond to control inputs I could save it when it fell out of failed crankshafts nose down. Let it fall a bit while adding a squirt of power and it responds crisply to the elevator and flies away. Over the last few months I have learned to depend on the near-instant recovery characteristics of the Extreme Flight 78" Extra 300.
The folks that know me best know that I am a fanatical rudder user. The rudder on the Extreme Flight 78" Extra 300 is huge and can respond on that level at nearly any speed. Add some expo and the rudder remains effective but softer around center stick where we want that kind of fine control.
When we have southerly winds at our field I like to do a 45-degree approach to the runway, aiming roughly at the center of the 500-foot-length. As the Extreme Flight 78" Extra 300 gets to the edge of the runway a little right rudder countered by a touch of left aileron keeps the wing level as it turns and lands comfortably down the remaining runway. The Extreme Flight 78" Extra 300 handles so well at lower speeds that this kind of landing approach is surprisingly easy.
I originally equipped the Extreme Flight 78" Extra 300 with a 3 axis “stabilizer” (gyro) but I leave it turned off except on landing in turbulent winds. I felt like it was trying to correct things I wanted the plane to do even though I had the gain settings very low. The Extreme Flight 78" Extra 300 just flies better with huge control surface throws and a moderate amount of expo, around 40%.
When I was trying to learn the “crankshaft” maneuver (practice of this maneuver is in the video below) I felt like the gyro was working against me. When I turned the gyro off the Extreme Flight 78" Extra 300 entered the maneuver more easily and seemed to use its energy more effectively. Other moves such as the knife edge spin were easier to get into and tighter overall with the gyro turned off.
When I got the Extreme Flight 78" Extra 300 my intention was to build a 3D-capable hot rod and that is what I ended up with. The Extreme Flight 78" Extra 300 is very “active” when tossed around in the sky and is far more capable than I am. I like that the Extreme Flight 78" Extra 300 is predictable and consistent, traits that make learning new maneuvers less of a chore. My recent exploration of the Extreme Flight 78" Extra 300 flight envelope also proves that the airframe is very strong and capable of surviving my occasional high-speed dumb-thumbs mistakes that stress the structure more than normal.
With its extensive aerobatic capabilities, the Extreme Flight 78" Extra 300 is a puppy to land. It slows to a walk and floats with the best of them. I have found myself having to add a few clicks of down elevator to help get the Extreme Flight 78" Extra 300 to the ground when landing into winds of 10 mph or more. It just wants to fly when there is a bit of air flowing over the wings.
All Flyingrc.net written, photographic and drawn materials are property of and copyright by Tom Hintz and Flyingrc.net 2013-2017. Materials cannot be used in any way without the prior written permission of the owner.

domain: design


HEALTH, SAFETY & ENVIRONMENTAL STANDARDS
We recognise our responsibility to our employees, the community and the natural environment in the areas of safety, health and environmental protection. We place a strong emphasis on the integrity of our services and on compliance with environmental and other relevant regulations.
The safety and health of our employees, the well-being of our stakeholders and the mitigation of environmental impact remain a company priority.
GED Africa cares for its workforce and strives to maintain a safe workplace environment. The health and safety of our workforce is a top priority – we want every employee to return home safely and in good health at the end of their working day.


Trelleborg’s offshore operation has recently been awarded DNV-GL certification for its Vikodeck™ fireproofing tiles. Manufactured using Trelleborg’s next-generation Firestop™ material, the newly certified Vikodeck™ tiles are lighter and thinner than any current passive fire protection materials available to the market and can be tailored to withstand various chemical and mechanical conditions.
Vikodeck™ is designed to offer surface protection against blast, jet and pool fire in harsh demanding environments, while also providing corrosion protection and anti-fatigue dampening support for the comfort and safety of employees. The flexibility of Vikodeck™ allows the tiles to withstand movement as well as impacts that could possible damage or crack a rigid system.
Christian Kolderup, Project Engineer for Trelleborg’s offshore operation based in Norway, states: “Trelleborg is committed to supplying high performance, robust and dependable solutions that significantly improve safety to protect personnel, equipment, critical components and structures in demanding environments both onshore and offshore.
“By obtaining DNV-GL certification for the thin and light Vikodeck™ tiles, we intend to identify new applications for the material in markets other than in the oil and gas.”
In addition to the existing fire properties, Vikodeck™ is impact resistant and capable of withstanding heavy loads. It dampens vibrations, provides significant sound attenuation, and has good resistance against ozone, UV-light and process liquids. Since the tiles are rubber-based, they are very flexible, water repellant and reduce the effect of an impact, minimizing wear on any protected surface.
Vikodeck™ tiles can be applied to flooring, walls, roofing or any surface needing protection. To meet demanding customer requirements in diverse applications, Vikodeck tiles are now available in four types:
- Vikodeck™ HF – protects according to certified hydrocarbon fireproofing requirements
- Vikodeck™ JF – protects and insulates assets in a possible jet fire scenario
- Vikodeck™ S – protects structures from hang fires
- Vikodeck™ L – for areas that need sound, impact, weather or tear protection
Firestop™ is a passive fire protection material used to protect personnel and equipment by minimizing fire escalation. This provides time to evacuate people, close down critical equipment and for responders to gain control of a fire. The certified rubber-based material protects structures from exceeding critical temperature limits. The dampening, noise reducing flexible nature of Firestop can also protect equipment from vibration, collision, explosion and even earthquakes. The newly developed next-generation fire-resistant material is thinner and lighter than any current passive fire protection materials available to the market.
Trelleborg is uniquely equipped to develop innovative, custom-designed solutions to provide wide-ranging benefits such as enhanced performance, increased safety, greater ease-of-use and improved comfort.
This press release is available for download in English. If you reproduce information from this release please give contact details as:


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A WA Police officer will face court today charged with stealing from a Rockingham store.
The Senior Constable, from the East Metropolitan district, is alleged to have stolen items from a sporting and camping goods store on two occasion in July and August.
He is scheduled to appear in Rockingham Magistrates Court this morning on two counts of stealing.
The Senior Constable has been stood aside from operational duties.
Originally published as Police officer charged with stealing


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Steel Dog Toys - Barnyard Baller - Donkey
There is a surprise inside every time! Within each toy, is another toy to play with. All plush toys will be destroyed, but having an additional toy (rope or tennis ball) inside lets playtime continue.
These are stuffed toys. Some have balls inside, ropes, squeakers or crinkle material. These are not made for chewers, but for dogs that love stuffed toys. If your dog is a chewer, we recommend the Indestructibone chew toy or the Ruff Dawg rubber toys that we carry. These are not kennel safe. They require supervision at all times.

domain: pet


The Shopkeeper - DVD w/ bonus perks
He’s worked with Carole King, Ani DiFranco, and a host of great Texas
artists — but can music producer Mark Hallman keep his studio open in
the age of streaming?
92 minutes - Stereo, 5.1, CC
• Gag Reel
• Collection of “Thank Yous” to Mark from beloved friends and clients
• A montage of killer jam sessions that occurred while we were filming
• An update on the statistics in the movie
Note: for purchasing the DVD directly from the website, you will receive perks unavailable to folks who buy elsewhere.
- A code for digital download of the film
All the cover songs that I recorded with Ojai guitarist Martin Young as part of the Indiegogo campaign
Mark’s and my rendition of Gillian Welch’s prescient 2000 anti-Napster song “Everything is Free”


text:
US Secretary of State John Kerry was to hold a second day of talks with Afghanistan's feuding presidential hopefuls on Saturday, seeking a deal to "clean up the tally" after disputed elections.
Kerry held talks late into the night on Friday in an effort to resolve Afghanistan's disputed presidential election, warning the two candidates that the country's transition to a self-reliant state hung in the balance unless the credibility of the vote was restored.
Despite back-to-back meetings, US diplomats said an accord was not yet on the table.
Kerry rushed to Kabul on Friday in a hastily arranged visit for talks with the two presidential contenders, Abdullah Abdullah and Ashraf Ghani, as well as incumbent President Hamid Karzai and other Afghan officials.
US officials said Kerry would hold a second round of talks on Saturday with all sides, starting with Abdullah, to weigh several ideas.
Preliminary results from a June 14 runoff vote put Ghani, a former World Bank official, in the lead, but Abdullah rejected the result, calling it a "coup" against the people and his aides have threatened to set up an alternative administration.
"Election legitimacy in the balance"
"The election legitimacy hangs in the balance, the future potential of the transition hangs in the balance, so we have a lot to do," Kerry said before his meetings with Jan Kubis, the United Nations' special envoy to Afghanistan.
Under a proposal put forward by the UN, the country's elections commission would audit ballot boxes from just over 8,000 polling stations where suspicions of ballot-stuffing have been raised.
While Ghani's campaign has embraced the UN plan, Abdullah's team remains skeptica, arguing the proposals to review some 35 percent of all votes do not address all their concerns.
On Friday, Kerry stressed that results released on Monday showing Ghani in the lead with some 56 percent of the vote were only "preliminary".
"They are neither authoritative nor final, and no-one should be stating a victory at this point in time," Kerry said.
Kerry was focusing on two tracks, a senior US administration official told AFP.
"One is cleaning up the tally, so to speak, to the extent possible so that the process is more credible. But two, creating a dialogue where the Afghans can have the conversation" on a path forward, the official said.
Abdullah's rejection of the outcome has set the stage for a possible bloody standoff between ethnic groups or even secession of parts of the fragile country, which is already deeply divided along tribal lines.
Abdullah, a former anti-Taliban resistance fighter, draws his support from the Tajik minority in the north of the country. Ghani has strong support from Pashtun tribes in the south and east.
US-based analyst Anthony Cordesman on Afghan election
Ghani, speaking earlier, said he favoured a comprehensive audit. "Our commitment is to ensure that the election process enjoys the integrity and the legitimacy that the people of Afghanistan and the world will believe in," he said. "Therefore, we believe in the most intensive and extensive audit possible to restore faith."
Abdullah, for his part, said after meeting Kerry: "At a very critical time, you have proved your commitment to Afghanistan, to saving Afghanistan and saving the democratic process here."
US State Department spokeswoman Jen Psaki told Reuters that an agreement on a broad review of the votes would be an initial step to enable the candidates to talk through their differences.
"Secretary Kerry's goal is to help the parties find a way forward that ensures that the next president of Afghanistan has a credible mandate to lead a unified Afghanistan," she said.
The United States believes the results of the final tally in the second round should not be released until the audits have been completed.
Kerry has warned that any effort to resolve the dispute through violence or any "extra-constitutional means," would cause the United States to withdraw assistance to Afghanistan.
The United States is in the process of withdrawing its forces from the country after 12 years of fighting Taliban insurgents, but remains the country's biggest foreign donor, helping to fund the operations of the Afghan government.
(FRANCE 24 with AFP, Reuters)
Date created : 2014-07-12


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The role of infrastructure protection programs is to guarantee safety and well-being of the population and eliminate a broad range of factors that may lead to tremendous losses. It helps to assess vulnerabilities and address associated risks. The situation has become particularly problematic because of an increase in terrorist activities, which are difficult to predict, and many scholars have tried to develop recommendations and preventive measures to expand the level of safety of the infrastructure. The article under discussion is "The Challenge of Protecting Critical Infrastructure" by Auerswald, Branscomb, La Porte, and Michel-Kerjan.
Auerswald et al. (2005) start the article by discussing the role of the government in the protection of infrastructure. They suggest that one of the problems limiting the overall security of facilities is that many enterprises believe that additional expenses are unjustified and lack motivation to support the elimination of vulnerabilities. They criticize the idea that market forces can influence decision-making in this area and argue that this factor is relatively insignificant because most firms focus primarily on profits without considering risks associated with the infrastructure. About ninety-five percent of all the facilities and structures belong to the private sector, which limits the influence of the government because most citizens do not recognize the importance of globalization. Additionally, associated risks are interdependent most of the time, and it affects some industries more than others. Therefore, the authors claim that policymakers should address some limitations of the current legislation, and a close collaboration between the government and the private sector will help to increase security of infrastructure. They discuss the accident that happened in 2004 to highlight the importance of federal intervention. Policymakers failed to recognize the dangers associated with toxic-inhalation-hazard, and officials did not expect many incidents because of the failure to address this security risk.
The authors acknowledge the fact that both sides have different priorities, and conflicting needs lead to disagreement on this subject matter. Moreover, they argue that only the government may oblige corporations to invest in preventive measures because they do not have any incentives to reduce risks. They also mention that terrorism is not the only threat to national security. Therefore, it is imperative to consider dangers associated with natural disasters when developing national programs. The authors mention that professionals in this area have started to consider the ways in which they may minimize vulnerabilities even before the September 11 attacks. Terrorist incidents facilitated the development of preventive measures and effective policies. Scholars have conducted a broad range of studies on this subject matter, but the authors of this article argue that they have numerous weaknesses. They suggest that the biggest problem is that scholars overlook the importance of such factors as competitive pressure or resource restrictions, which have a tremendous influence on the decision-making of private firms. Also, they believe that the effectiveness of protection is relatively small when it comes to terrorist attacks because they always seek vulnerable targets. Therefore, the central argument is that policymakers must prioritize the development of capabilities related to prevention and efficient response measures. Furthermore, it may help firms to recover as fast as possible and minimize associated losses. The authors also provide a list of recommendations that policymakers may consider when developing national programs. They are quite comprehensive and take the needs of the affected firms into consideration.
Another challenging aspect is that most companies focus only on factors that are directly connected to their activities because some of the links with other infrastructure elements are not clear. The authors recognize that probability of occurrence are incredibly low in some cases. Therefore, it is not surprising that most firms disregard the need to address vulnerabilities that are not clear or difficult to assess. The article shows that many business owners are more likely to act irrationally or reckless if they know that insurance protects the business. The problem is that this aspect promotes risky behavior and introduces a moral hazard. Additionally, the authors draw attention to the fact that there is no direct connection between the available security measures and the price of insurance. It is understandable that it may be difficult to determine an appropriate cost, but enterprises and the government should not overlook this issue.
It is possible to state that the article has many advantages. First of all, the authors managed to cover critical issues related to the infrastructure protection. Most of presented arguments are convincing because the authors link the discussed challenges to particular events and highlight the lack of incentives that would support cooperation from the side of the public sector. A relationship between national security and infrastructure protection is evident. Therefore, it is impossible to deny the fact that intervention from the side of the government is justified in most cases. One of the biggest strengths of the argument is that the authors recognize the necessity to limit the imposed costs because the economy of a country may suffer if the government forces firms to invest in infrastructure protection without any clear benefits. Additionally, the authors understand that the approval of the general public is also incredibly important. Such policies may affect the prices and lead to other inconveniences. Therefore, it is paramount to increase awareness and provide all the necessary information about the dangers related to vulnerabilities of the infrastructure. Moreover, it is mentioned in the article that terrorism is an enormous threat to national security, and the government should take all necessary measures to protect citizens (Martin, 2012). As it is impossible to prevent all attacks, many businesses do not want to support projects that offer relatively small benefits. The authors consider the perspective of such firms and acknowledge that insurance companies can improve their pricing strategies. They also recognize that interactions between the involved parties may help to improve national security as a whole, but it requires cooperation and well-developed policies that acknowledge the interests of all stakeholders. Another advantage of this article is that the central argument is that policymakers must prioritize sustainability over other aspects, and this approach is reasonable because it provides various benefits apart from elimination of vulnerabilities.
One of the limitations of the article is that the discussed policies increase the influence of the federal government, and the authors did not acknowledge the fact that many individuals oppose such expansion. It is understandable that well-being of the population is at risk because of the current vulnerabilities, but it is necessary to reach consensus on this subject matter before suggesting any radical measures. Moreover, the authors overlooked the impact of new technologies and did not recognize that terrorists may coordinate cyber-attacks aimed at critical infrastructure systems. They could have mentioned that such activities threaten national security because most facilities do not implement appropriate preventive measures (Amoroso, 2012). Also, they do not discuss the importance of maritime security and associated threats. The approach is questionable because ports are usually regarded as the critical part of the infrastructure and thus maritime safety levels are paramount for a country such as the United States (Lewis, 2014). Moreover, various industries may require different approaches to maximize efficiency of operations.
The most significant problem with this article is its structure. The authors did not split the presented information into sections, which makes it difficult to assess the quality of arguments. The central issue is that the authors discuss various topics without proper transitions or conclusions. Therefore, it may be challenging to find information that interests a reader. Although the data provided in the article is accurate and comprehensive, it lacks an in-depth analysis and detailed descriptions. The authors provide a list of strategies that professionals in this area may consider when dealing with some of the challenges associated with protection of critical infrastructure. However, they are too vague, and the authors do not provide additional information that would help to understand such recommendations. Nevertheless, one may regard it an excellent source that allows expanding knowledge in the area of infrastructure protection.
How It Works
In summary, the article manages to convince the target audience that the government should develop a set of policies that would support elimination of current vulnerabilities related to the infrastructure. The authors justify their statements by showing that ineffective legislation threatens national security and may lead to tremendous losses. Additionally, they provide examples of adverse effects of some of the limitations in this area and discuss the ways in which the government may address related incidents. I would recommend this article to others because the authors raise a series of important issues. However, one of the issues is that the authors focus only on a particular perspective and do not offer alternative solutions. It is understandable that the primary goal of this article was to cover the most significant problems of homeland security and explain how the government may address them, and the authors have successfully accomplished this objective. Therefore, the article is of great value for the homeland security community. However, the presented information is insufficient, and one may have to review other sources to get a better understanding of the topic. Overall, this article has both strengths and weaknesses, but positive aspects outweigh negative ones.


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text:
Ta Kroupia Grill in Agia Marina Leros
In Leros, in the beautiful Dodecanese, next to the deep blue sea, in the beautiful harbor of Ag. Marina, there is the Grill "Ta Koupia" since 1994. Quality, quantity, taste and good prices are combined for your own satisfaction. In our grill you can taste and enjoy grilled meats, roasted spits, souvlaki, round, grilled chicken all with local meat of our island. In a pleasant and clean environment we expect you to enjoy all the flavors.


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Hi! I’m Giada. I like to pose for pictures as you can see! I have the most gorgeous eyes! Won’t you come and visit me to see how very sweet I am???
Giada is approximately 7 months old and looking for a home of her own. If you’d like to meet this beauty, please visit PetValu in Island Park, NY.
All our cats are spayed or neutered prior to adoption, up to date on vaccines, tested for FIV/FeLV (feline AIDS & leukemia), treated with flea preventative, and microchipped (which we will register for you).
If you’d like, please download our application from www.bobbiandthestrays.org and email it to firstname.lastname@example.org. Thank you very much!


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Nike Campaign Features Marvin The Martian Mets Affiliate To Be Called Columbia Fireflies WNBA's Breast Cancer Awareness Week DeKalb Approves $30 Soccer Facility HBO's "Back On Board: Greg Louganis" Judge: No Vote Needed For Rams Stadium Funds Classified Advertisements PGA Championship Seeing Record Sales Former UGA AD Evans Now An Asset To Maryland Big Ten Phasing Out FCS Opponents
Sports On Earth's Joe Posnanski Leaving Site To Join NBC Sports
Published January 29, 2013
"We're hopeful to have information regarding Joe Posnanski in the near future," NBC said in a statement earlier today. MLBAM Exec VP/Content Dinn Mann said, "We wish Joe the very best. Our commitment to enhance the dialogue with well-written opinion remains unchanged."


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Gosford Park & a discussion about the work of one of America's greatest filmmakers
Hosted by Bob Balaban
Movie screening of Gosford Park followed by a talkback hosted by Bob Balaban, with Guilia D'Agnolo Vallan and Kathryn Altman - widow of the late Robert Altman
A British murder mystery satire that's drawn comparisons to Jean Renoir's classic Rules of the Game and Ten Little Indians, based on the novel by Agatha Christie. The scene is 1930s England, where an aristocratic family and their friends enjoy a hunting party weekend. But are there killers among them? The film features multiple storylines, showing the fairly boring lives of the rich and famous upstairs, and the more intriguing ones of the servants downstairs.
Following the event, there will be a book signing of the biography Altman by co-authors Kathryn R. Altman and Giulia D'Agnolo Vallan
For decades, Robert Altman fascinated audiences with pioneering films—among them M*A*S*H, Nashville, The Player, and Gosford Park—that combined technical innovation with subversive, satirical humor and impassioned political engagement. His ability to explore and engage so many different worlds with a single, coherent vision changed the landscape of cinema forever. This signature "Altmanesque" style is, in the words of Martin Scorsese: "as recognizable and familiar as Renoir's brushstrokes or Debussy's orchestrations." Now, the Altman estate opens its archive to celebrate his extraordinary life and career in the first authorized visual biography on the iconoclastic director. "Altman," by Altman’s widow Kathryn Reed Altman and film critic Giulia D’Agnolo Vallan, brims with photographs and ephemera, many culled from private family albums, and personal recollections of the director. Alongside the intimate illustrated story is a complete visual, historical, and critical narrative of Altman’s films and his process. To honor the Altman trademark of using a wide cast of characters, Altman also features contributions from his collaborators and contemporaries including Frank Barhydt, E. L. Doctorow, Roger Ebert, Jules Feiffer, Julian Fellowes, James Franco, Tess Gallagher, Pauline Kael, Garrison Keillor, Michael Murphy, Martin Scorsese, Lily Tomlin, Alan Rudolph, Michael Tolkin, and Kurt Vonnegut Jr.

domain: library


text: I love movies! I’ve decided to share my list of what I consider my “Personal Classics”. I define ‘personal classics’ as films that a person enjoys enough to watch over and over through many years. Each individual will have different movies in their classics list and I doubt most folks lists will mirror the lists of professional film critics, although both will probably contain many of the same movies. You will notice a lack of certain genre in my personal list; horror, action-adventure, and animation for example. You will probably, however, notice a preponderance of old films. You will also over time discover that I have very odd taste in films. You will find that I love period pieces or anything that has beautiful clothes. I actually like foreign films particularly Chinese and Indian movies (can you say Bollywood). I’m not terribly fond of musicals but I do like some things that some may consider meer “fluff”. And I like listening to foreign accents for some strange reason. Anyway, I hope that you find a little gem or two in my list to add to your own classics list and I hope that you will share your list with me. So grab your popcorn, sit back, and enjoy!

domain: artistic


Commentary: The landscape of America’s TV and communications providers is becoming a jumbled mess. The potential thrill from this shake-up is how it could inject more competition, more choices and lower prices in what has been a fairly stuffy market. Maybe.
Another thing the internet is destroying is the once-bright lines that divided the U.S. companies that sell TV service, landline and mobile phone plans, and internet access.
U.S. cable TV companies started adding phone and internet access to their offerings about 15 years ago. Now the two biggest U.S. cable companies are getting into mobile phone service, too, though only in places where they already offer TV and other services for now.
At least one of them, Comcast, will also soon sell a collection of channels similar to cable TV but delivered over the web. Satellite TV companies Dish Network and AT&T’s DirecTV are already selling such internet TV packages in addition to their more conventional TV offerings. Technology changes may mean people’s mobile-phone providers will also be able to give them home internet connections.
Confused? It’s understandable. The landscape of America’s TV and communications providers is becoming a jumbled mess. The potential thrill from this shake-up is how it could inject more competition, more choices and lower prices in what has been a fairly stuffy market.
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Maybe. Or maybe it entrenches powerful companies even more, sows confusion and pushes prices higher. Isn’t the future grand?
For now, TV service has become the most dynamic area of the communications and entertainment market, most likely because of the revenue up for grabs and the particular pressures from changing consumer behavior.
Cable, satellite and phone companies that sell TV service generated $116.3 billion in revenue last year in the U.S., according to Kagan, a group within S&P Global Market Intelligence. The revenue for internet access was about two-thirds of that size, Kagan estimates. At the same time, fewer people want conventional TV packages that cost on average $83.40 a month at industry leader Comcast, and instead are opting to ditch TV service or trade down to lower-priced options.
That’s one reason DirecTV is introducing online TV packages, soon to be joined by Comcast and Verizon. For them, options like DirecTV Now are a hedge against a future when many more people dump TV. Technology companies are jumping in, too, by offering packages of TV channels similar to cable TV, or giving people options to assemble their own collections of TV entertainment or watch TV programs tailored for Snapchat.
Internet service is not as competitive, in part because of the costs of building pricey networks to spread internet access to U.S. homes and businesses. But potential shake-ups are possible here, too.
Mobile phone service was stodgy for a long time, and then a revived T-Mobile US changed all the industry’s rules and spread consumer-friendly prices and more options to Americans. If Comcast and Charter Communications push their wireless service hard — and that is no sure thing — then many Americans may be able to pick among five or more large mobile companies. Maybe Amazon or another tech company could play spoiler in wireless or broadband service, too. The development of the next-generation mobile standard known as 5G might erase the line between home and mobile internet.
But it’s also possible the jumbled mess of TV and communications could be a letdown. It’s not clear there is a motivated challenger like T-Mobile was in wireless that has a big incentive to reshape TV or communications to Americans’ benefit.
The cable companies at the moment are sticking to their existing pockets of the country for new wireless service and online TV options. That means Comcast and Charter most likely see their new products as ways to keep existing customers and squeeze more from their monthly bills — not as a way to shake up the ways most people buy entertainment and communications.
Apart from Netflix and Amazon, demand for new types of TV entertainment doesn’t seem robust at the moment, and that could stop future TV experiments from getting out of the gate. Home broadband is the linchpin for nearly every future entertainment or communications service, but most Americans have very few choices of providers and pay a lot for subpar service. That doesn’t seem likely to change soon.
All this means the future might be dynamic and exciting, or the future could turn out not too different from our frustrating present.


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Take a little spree to Decul Brook since you're here at Island Pond, and during your journey here you'll meet some folks from Stoddard for sure. Seven Maples Campground is a wonderful local campground; the top of Mount Stoddard is easily made out from Island Pond. This lake is so wonderful. If you have a thing about the outdoors, you'll go for Island Pond. While you're here at Island Pond you can take a hike along
the Monadnock Sunapee Trail, and if you came for an overnight stay Idle Times Campground is a delightful place to camp. So many exciting things to do here at Island Pond, too fine to be true.


The smelting furnaces are connected to heat exchangers using a custom construction made by ZPF therm. The design engineers reacted to our requirements with a positive, 'can-do' manner", says Konrad Schmittlein, operational manager at JURA-GUSS.
Source: JURA-GUSS GmbH
Whether by solar thermal systems or heat pumps - in heating engineering, any way of supplying cheap energy is welcome. Until now, relatively little attention had been paid to the many sources of heat available in industrial plants. In particular, hundreds of kilowatt-hours of heating energy are lost every day in the exhaust gases emitted from smelting works and foundries. But now, the JURA-GUSS aluminium foundry has taken the step of connecting its melting furnaces to a system of heat exchangers, which then not only feed the space heating systems within the plant but also heat up the water used for cleaning the castings. The furnaces themselves are designed to be efficient with resources, which means that they are also well-insulated, to maximise the amount of melting heat available. Moreover, the furnaces, which are produced by melting furnace manufacturers ZPF therm, produce very little exhaust gas, thus allowing the foundry not only to save energy, but also to protect the atmosphere by reducing CO2.
JURA-GUSS GmbH in the Bavarian town of Beilngries produces around 300,000 castings per year for manufacturers for both small and large vehicles, international mechanical engineering companies and medical engineering firms. In all of these fields, environmental protection is of major importance. For instance, dust produced during by sand casting is removed by a suction system and the spent moulding sand subjected to a complex reconditioning process. Moreover, the company only uses rainwater from its own cistern. Not only that, but all castings are washed with water-based solvents, which circulate in a closed system. Clearly, the next logical step was to maximise the efficiency of its melting furnaces in compliance with low energy and resource consumption requirements.
Special exhaust gas flues reduce furnace pollutants
Heating using exhaust process heat is on the increase: we are meanwhile receiving more and more enquiries for waste heat recovery techniques, says Leonhard Gutsche, design engineer at smelting furnace manufacturers, ZPF therm, which already implements exhaust heat recovery.
Source: Henrik-Gerold Vogel, pixelio.de
The exhaust gas systems from the four smelting furnaces at JURA-GUSS are connected to heat exchangers by means of bypasses. These transfer the heat from the smelting process to the circulating water.
Source: JURA-GUSS GmbH
The biggest furnace is sunk into the floor, which also makes it easier to clean. To empty the melt, the furnace is tipped into a cavity in the floor.
Source: JURA-GUSS GmbH
Since 1994, JURA-GUSS has been using melting furnaces manufactured by ZPF therm GmbH from Baden-Württemberg. Recently, the company installed its biggest furnace so far, comprising a system with a melting rate of three tonnes per hour and a holding capacity of ten tonnes, originally an exhibit from the GIFA 2007. "For us, a decisive factor was that fact that this furnace's consumption when holding was 100-120kWh of gas, which is very low," explains Konrad Schmittlein, operational manager at JURA-GUSS. "And not only that, the systems already comply with air quality regulations (TA Luft), so it is not necessary to install any additional exhaust gas cleaning systems."
All of these benefits are down to the special construction of the combustion chamber: the gases that form during the smelting process are not released directly through the chimney, in accordance with the principle of reverse air flow, but remain inside the furnace. This causes pollutants to be combusted, resulting in a very low dust particle content of less than three milligrams per cubic metre and a hydrogen fluoride content of only 0.4 milligrams. Another advantage of the technique is that heat from the exhaust gases can be used for heating the holding bath, which reduces both fuel consumption and CO2 emissions.
Exhaust fumes supply energy for heat exchangers
The flexible attitude shown by the furnace makers was central to the success of JURA-GUSS's objectives. More than just performing their standard functions, the goal was to recycle energy from the furnaces to serve the company's service water heating requirements. "In this respect, the design engineers reacted to our requirements with a positive, 'can-do' manner," says Schmittlein. Special connecting pieces were built into the furnace's exhaust gas systems, through which to divert the hot air. "If the outlet is connected to a chimney, the exhaust gases flow through this bypass to a heat exchanger, which transfers the process heat to the circulating service water," explains Leonhard Gutsche, design engineer at ZPF therm.
Altogether two heat exchangers, one for the large melting furnace and one for three smaller systems are in use; these heat up a 30,000-litre reservoir, the water from which supplies 80% of the production building with heat. It also heats the company's washing system for finished castings. The large furnace alone has two 1,000kW burners. After melting, as much as 35-40 percent of their heating energy flows to the heat exchanger, which converts around 75 percent of it into usable heat. The heat produced means additional heating is only required at weekends or any other times when little exhaust heat is available; two gas boilers of 400 and 200 kW are used for this purpose.
Lower-standing furnace now easier to clean
Another advantage of the new furnace is that a higher melting rate has been achieved without requiring an increase in personnel. This is in part due to the feeding mechanism of the system, which charges each batch in a single step, without the ingots needing repositioning. The main advantage, though, is that the furnace is now considerably easier to clean: as the new smelting furnace now stands 70cm lower in the ground, it can be cleaned quite easily from both sides, without any pedestals or other aids. All areas of the furnace are accessible through the large cleaning openings. To empty the melt, the furnace is tipped into a cavity in the floor, and the transport ladle is then transported upwards by a hydraulic mechanism.
This solution is one of the standard options available from ZPF therm. The connection system, however, was developed especially for JURA-GUSS. "We are meanwhile receiving more and more enquiries for waste heat recovery techniques. We are currently working on several projects in this area," says design engineer, Leonhard Gutsche.


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Room 1.1: Cancer
Presenter: Pieter Schol
Title: AR ENHANCER HETEROGENEITY IN PROSTATE CANCER: IS IT FUNCTIONAL?
Lab: Division of Oncogenomics, The Netherlands Cancer Institute
Androgen receptor (AR) is a main driver of prostate cancer (PCa), a major cause of death in men worldwide. PCa therapies inhibit AR signaling, but tumors often develop into castration resistant PCa (CRPC), which is untreatable and ultimately lethal. Understanding CRPC development is therefore of major research interest.
When bound to its ligand DHT, AR regulates gene transcription by relocating to the nucleus and binding to AR binding sites (ARBS). Only a small minority of ARBS are found at gene promoters, and most are located distally from a gene’s transcription start site. This suggests that AR mediates transcription predominantly through enhancers. ChIP-seq analysis of patient samples shows an interpatient variability in ARBS. Many are patient-unique, but some are shared by the majority of patients. It is currently unknown whether these different classes of ARBS also have different functional consequences on transcription.
In this project, we interrogate such functional differences by deleting individual enhancers with CRISPR/Cas9, and assess individual ARBS’ contribution to gene transcription. Understanding ARBS heterogeneity in PCa could open avenues to assessing the clinical effect of ARBS heterogeneity, and ultimately enable more personalized treatment.
Presenter: Marlies Oosthoek
Title: PANCREATIC CANCER-ASSOCIATED FIBROBLASTS INFLUENCE CHEMOKINE RECEPTOR EXPRESSION IN T CELLS
Lab: Laboratory of Medicine, Karolinska Institutet
Pancreatic cancer is known for its dense and immunosuppressive tumour microenvironment. Amongst other cell types, cancer-associated fibroblasts (CAFs) make up a great deal of the stroma of pancreatic cancer. CAFs have been known to influence the tumour microenvironment by releasing cytokines, chemokines and extracellular matrix proteins. The aim of this study was to investigate how CAFs influence chemokine receptor expression on T cells. We investigated this by comparing chemokine receptor expression on peripheral blood mononuclear cells (PBMCs) co-cultured with CAFs or tumour spheroids or both. We also examined the functionality of T cells in the presence of CAFs and PANC-1 spheroids. Finally, the expression of chemokine receptors was investigated on tumour-infiltrating lymphocytes isolated from tissue samples. CAFs upregulated CXCR4 expression on CD8+ T cells and CCR4 expression on CD4+ T cells in the presence of tumour spheroids, while there was a decrease in CXCR3, CCR5, and CCR6 expression on CD8+ T cells in the presence of CAFs and tumour spheroids. We also show there was lower expression of granzyme B, interferon-γ and perforin in the presence of CAFs and tumour spheroids. Functionality was further impaired in the population that highly expressed CXCR4, as there was lower granzyme B and interferon-γ production. Furthermore, there was a distinct chemokine receptor expression pattern on tumour infiltrating lymphocytes in pancreatic cancer compared to other cancer types. Combined, these findings show that CAFs impair functionality partly via increasing CXCR4 and that CAFs potentially influence immune cell recruitment via affecting their chemokine receptor expression
Room 1.2: Neuro(muscular)
Presenter: Marlies Wagener
Title: QUALITY ABOVE QUANTITY: DISSECTING INSOMNIA SYMPTOMS FROM SHORT SLEEP DURATION IN RELATION TO CORONARY ARTERY DISEASE: NEW EVIDENCE FROM MULTIVARIABLE-ADJUSTED AND FACTORIAL MENDELIAN RANDOMIZATION ANALYSES
Lab: Department of Internal Medicine, LUMC
Background: Multivariable-adjusted and Mendelian Randomization (MR) studies identified both insomnia symptoms and short sleep duration as risk factors for coronary artery disease (CAD). Since sleep is a modifiable risk factor, it is important for targeted treatment to understand how insomnia and sleep duration independently contribute to CAD risk. This study aimed to dissect insomnia symptoms from sleep duration in relation to CAD and serum lipid levels.
Methods: We stratified participants from the UK Biobank (consisting of over 500.000 participants aged 40-70) into subgroups based on the presence of insomnia symptoms and short (<7h), average (7-9h) and long (≥9h) sleep duration. Data on insomnia symptoms and total sleep duration was collected through self-reported questionnaires. We used multivariable-adjusted Cox proportional hazard models, linear regression models and factorial MR. MR analyses used genetic risk scores for self-reported total sleep duration and insomnia symptoms. In all analyses we used CAD and serum lipid levels as outcomes.
Results: In the multivariable-adjusted Cox proportional hazard model, a combination of short or long sleep duration was associated with the largest increase in CAD risk. In factorial MR analyses, effects of genetically-influenced insomnia symptoms and CAD were the same in groups of genetically-influenced short (OR: 1.15; 95% confidence interval: 1.11-1.19), average (1.09; 1.07-1.12) and long (1.08; 1.00-1.16) sleep duration. Short and long sleep duration were not associated with CAD in individuals with either a low or high genetically-influenced risk for insomnia symptoms. Furthermore, we found that insomnia symptoms were only associated with elevated blood triglycerides and not LDL cholesterol.
Conclusion: Our research shows that CAD risk and increased triglyceride levels are driven by insomnia symptoms and not sleep duration. Interventions targeting insomnia might therefore be more effective in CAD prevention than those targeting short sleep duration.
Presenter: Marloes Holierhoek
Title: ASSESSING BENEFICIAL EFFECTS OF DIETARY SUPPLEMENTATION OF BRANCHED AMINO ACIDS IN A SEVERE MOUSE MODEL FOR DUCHENNE MUSCULAR DYSTROPHY
Lab: Department of Human Genetics, LUMC
Duchenne muscular dystrophy (DMD) is a severe X-linked neuromuscular disorder resulting in progressive muscle weakness and atrophy. The absence of the dystrophin protein in DMD patients leads to contraction-induced muscle fiber degeneration. Regeneration of these muscle fibers is impaired, and eventually the fibers get replaced with fibrotic and adipose tissue. As a result of the continuous muscle fiber degeneration and regeneration cycles, protein demands in DMD patients are increased. It is believed that patients might have insufficient protein intake to meet these increased demands, resulting in amino acid deficits. Since there is no cure for DMD at the moment, patients often resort to nutritional supplements to improve their disease progression. However, effects of nutritional supplements on disease pathology are still unclear. Branched-chain amino acid (BCAA) supplementation is a promising candidate to meet the need for the increased protein demand. The BCAAs are among the essential amino acids and are demonstrated to be involved in the activation of protein synthesis pathways and to promote muscle repair in mdx mice. In this study, we investigated whether BCAA supplementation can improve muscle pathology in D2-mdx mice, a relatively new DMD mouse model. In addition, we assessed if BCAA supplementation is affected of affects treatment with the corticosteroid prednisolone, as this drug is frequently used by DMD patients to slow down the progression of the disease. D2-mdx males were fed either a normal diet or a diet supplemented with BCAAs, for nine weeks. In addition, the mice received either prednisolone injections or saline injections. It was found that the modified diet could not improve in vivo muscle functionality, nor did it influence bodyweight or weight of individual muscles. Furthermore, preliminary findings suggest that the BCAA diet also did not affect the severity of muscle fibrosis, calcification, and regenerating muscle fibers in the D2-mdx mice.
Room 1.3: Immunology
Presenter: Tim van Tienhoven
Title: THE ROLE OF REGULATORY T CELLS IN IMMUNOTHERAPY RESISTANCE IN AN IN VIVO MESOTHELIOMA MOUSE MODEL.
Lab: Department of Pulmonary Medicine, Erasmus MC
Malignant pleural mesothelioma (MPM) is an aggressive cancer that originates from the mesothelial cells lining the pleura. Incidence rates are increasing worldwide, and the disease is generally characterized by a poor prognosis. Besides conventional therapies, it has been shown that the newly-emerged strategy of immunotherapy with checkpoint inhibitors (ICI) is also ineffective in the majority of MPM patients. To increase the number of patients with durable response following immunotherapy, we sought to determine mechanisms of ICI therapy resistance. As regulatory T cells (Treg cells) are an highly immunosuppressive subset of T cells that are able to express immune-checkpoints proteins, they could potentially be involved. It is hypothesized that ICI therapy unleashes Treg cells from checkpoint inhibition, allowing them to impede anti-tumor immunity and induce ICI therapy resistance.
To determine whether Treg cells play a role in the resistance against ICI therapy, we used an ICI-resistant mesothelioma murine model by which mice were inoculated in the peritoneal cavity with the mouse mesothelioma cell line AE17-OVA and were treated with αPD-L1 ICI therapy. Following therapy, Treg cells were isolated from tumors and secondary lymphoid organs and were examined for transcriptional alterations, expression of immunoregulatory proteins, and their functional suppressive capacity.
We demonstrate that αPD-L1 treatment increases the expression of immunosuppressive genes, including Il10, Havcr2, and Fgl2, especially in PD-1+ Treg cells. Besides, we reveal that Treg cells become highly proliferative upon αPD-L1 treatment, as indicated by an increased Ki67 protein expression, and become functionally more potent in suppressing naïve CD8 T cells. The enhanced suppressive capacity of Treg cells following αPD-L1 ICI therapy was not restricted to tumor tissue but was observed in secondary lymphoid organs, indicating a systemic phenomenon. Collectively, our data indicates that Treg cells may play an important role in the resistance against ICI therapy, and provides an insight on how these Treg cells could induce this resistance.
Presenter: Mette Dekkers
Title: DEVELOPMENT OF HYPOIMMUNOGENIC HUMAN INDUCED PLURIPOTENT STEM CELLS FOR TRANSPLANTATION PURPOSES
Lab: Department of Nephrology, LUMC
Introduction: Despite being the solely curative treatment for end-stage organ disease, the success of organ transplantation is hampered by shortage of donors and the need for immunosuppressive medication. The recent progress in cellular reprogramming has led to the idea of using induced pluripotent stem cell (iPSC)-derived tissue as an alternative to conventional organ transplantation. In this study, we aim to develop universal hypoimmunogenic human iPSCs, which are resistant to allogenic immune rejection.
Methods: To prevent attack by the complement system, complement regulatory protein CD55 was knocked-in in human iPSCs using CRISPR/Cas9 technology. To inhibit T cell mediated rejection, B2M, which encodes the light chain of HLA class I, was knocked-out. Following verification of the genetic modification, protection against complement activation, T cell and NK cell responses was evaluated in vitro in serum incubation and coculture assays.
Results: CD55 knock-in iPSCs show reduced C3 and C5-b9 deposition, reflecting inhibition of complement activation, compared to controls. Upon differentiation to endothelial cells (ECs), ECs display only modest complement deposition and CD55 knock-in has a minor additional protective effect. In B2M knock-out iPSCs, HLA class I expression is absent. HLA-A2 specific CD8+ T cells induce cytotoxicity and produce IFNγ in response to HLA class I-positive controls, but do not respond to B2M knock-out iPSCs. Although it was hypothesized that absence of HLA class I would trigger the “missing-self” response, no response of NK cells to iPSCs, irrespective of HLA class I expression, has been observed, but this needs to be verified.
Conclusion: Together, these results illustrate that CD55 knock-in and B2M knock-out protects iPSCs from the complement system and allogenic CD8+ T cells, respectively. Further research is required to evaluate the immunogenicity in iPSC-derived cells, which are more relevant for clinical application, such as kidney organoids or pancreatic beta cells.
Room 1.4: COVID-19
Presenter: Daphne Bouwens
Title: ANTIBODY-DEPENDENT CELLULAR PHAGOCYTOSIS OR CYTOTOXICITY IN SARS-COV-2: WHAT THE VACC?
Lab: Bioassay Development and Automation, Janssen Vaccines
The newly emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the pandemic of coronavirus disease 2019 (COVID-19) and needs little introduction: it has led to millions of infections, and hundreds of thousands of fatalities worldwide. Infection takes place when the SARS-CoV-2 Spike (S) glycoprotein attaches to host cells via the ACE2 receptor. Upon entry via endosomes, fusion of the viral membrane transfers viral RNA into host cytoplasm, where replication takes place.
The primary aim of vaccines against SARS-CoV-2 is to develop an effective and safe humoral response to control the worldwide pandemic. Antibodies that recognize the S protein can work in a (1) neutralizing manner, by directly engaging the receptor-binding domain of the S glycoprotein and preventing cell entry, or (2) non-neutralizing, by activating effector immune cells upon binding of the Fc region of the antibody to the immune cell (including macrophages and NK cells). Comprehensive understanding of these Fc-mediated effector function of antibodies against SARS-CoV-2 is critical in combatting disease, and these mechanisms are elucidated by developing an Antibody-Dependent Cellular Cytotoxicity or Phagocytosis assay (ADCC or ADCP, respectively, or ADCx in short).
The extent to which infection- or vaccine-elicited serum antibodies are able to induce ADCx activity is typically measured using a cell-based assay. In this research, the set-up of the ADCx assay is established, and each component of the assay is optimized. This optimization consists of choosing representative target cells, the optimal incubation time, and determining the titration range of convalescent sera and composition of the buffers. ADCx activity will be quantified using a luminescent read-out. In the end, this reporter-based ADCC and ADCP bioassay is used to characterize the Fc-mediated effector functions of (pre-) clinical serum samples of vaccinated donors against the SARS-CoV-2 virus.
Presenter: Nina de Beijer
Title: PURIFICATION OF CORONAVIRUS REPLICATION ORGANELLES
Lab: Department of Cell and Chemical Biology, LUMC
Coronaviruses are positive stranded RNA viruses that belong to the order of Nidovirales. Following the entry into the host cell, coronaviruses rearrange the host cellular membranes to establish replication organelles (RO), which mainly consist of double membrane vesicles (DMVs). Recently, it was proven that the double membrane vesicles (DMVs) that coronavirus induce are the sites of viral genome replication and that a pore connects the DMV interior to the cytoplasm. This pore, spanning the double membrane, could provide an exit for newly-made viral RNAs to be exported from the DMVs interior into the cytoplasm for translation and encapsidation. The structure of the pore was discovered using cellular cryo-tomography, allowing imaging of structures in their native state and their natural cellular context. However, the process of preparing samples from infected cells that are thin enough for cryo-EM analysis is incredibly laborious. To increase the resolution of the structure, the throughput of samples needs to be significantly higher and thus the sample preparation faster. To tackle this, we aim to purify coronaviral DMVs/ROs with intact pores, providing us with an in vitro system to study DMV and pore function. First, recombinant viruses, murine hepatitis virus (MHV) with an affinity tagged nsp3 were engineered and characterized. These tags could be used to pull down DMVs, since nsp3 is part of the pore complex spanning the DMV membranes. If the DMVs and pore remain intact, the created system can be used to study coronavirus replication in greater detail.
Presenter: Jonathan Benhaiem
Title: LAB SURVIVAL TACTICS
The lab is a treacherous place. At first sight, the biomedical lab is fun, exciting, and challenging. But underneath a layer of pipettes, 96 well plates and R code, lies a much more important and often overlooked aspect of the life at work: Lab Politics. Lab politics can be described as all diplomatic relationships between the stakeholders of a laboratory. As a student in the lab, you will encounter tricky situations, and everyone will have a different approach to solve these issues. Often, a solution can be found by following guidelines and recommendations from colleagues and your supervisors. But how do you deal when situations get out of hand, or when you have a problem with your supervisor? Understanding and reacting to motives and intentions is an invaluable tool to be successful in any environment. Managing your way through conflicts is learned mainly through experience. During the workshop, you may be assigned a role as a stakeholder in a scenario. In the end, the goal is to get acquainted with the power of Lab Politics and to be more confident in representing your ideals and motives in the lab!
Presenter: Soraya Schachtschabel
Title: HOW TO SPREAD THE AWESOMENESS OF (YOUR) SCIENCE
Imagine, you have worked in the lab for months and you finally get your most anticipated results. They are great and you can’t wait to share them with the world. But how? Research articles are great to convey your findings to fellow researchers, yet they are certainly not your average family member’s cup of tea. Letting the world (and your curious friends) know what you have done all that time behind a lab bench or a computer screen, and why your discoveries are worthwhile, is a key aspect of being a scientist. However, contrary to what you might think, it is not the easiest aspect. As all things in life, it takes practice to communicate science in the best way possible. But, once done well, science communication is a great tool to reach a broad audience and spark their enthusiasm in research. During this workshop we will discuss the further significance of science communication, look at tips on how to translate science to friends, family (and perhaps complete strangers) and put these tips into practice. At the end you’ll be ready to spread some science awesomeness!
Presenter: Esther Domenie
Title: LEARNING BY PRACTICE: CREATING INTERACTIVE SCIENCE LESSONS FOR CHILDREN
How to make science fun for children? I think we all remember science classes that were so boring that you rather would have done something else. Or, maybe, you do not remember them at all! However, as we all know, science is not boring but very interesting and exciting. At Technolab Leiden, where I am currently doing my internship, we want to engage children in science and teach them about science in an interactive way. At Technolab it is all about learning together, by DOING. In this workshop, we will create an interactive lesson for children about a scientific topic, following Technolab’s basic principles. What will be your role as a teacher, what is the goal of your lesson, how to engage children and what kind of methods are suitable for your topic? We will discover this and more during this workshop.

domain: medical


A pet shop which has been a prominent fixture in Dumbarton town centre for 25 years is set to be converted into a Pizza Hut takeaway.
Ryan’s Pet Centre on the High Street will be transformed into a branch of the global fast food chain after last week receiving the go-ahead.
But Joe Graham, who owns the well-established local business, assured customers he is not closing for good and has plans to move elsewhere in the town.
He said: “The lease is coming to an end next year on March 31 and we are waiting to move to another premises. If we can afford to stay in the High Street or Artizan centre, then we will.
“I don’t think moving will make any difference to us. It’s just a matter of getting premises suitable for our needs. It’s a bit too early to negotiate just yet. We will look at it in the new year.”
Joe took over the running of the shop after well-known businessman Robert Ryan, who established it, handed over the reins in 2013.
The takeaway, which will be run by franchise Sky Pizza, will employ two or three full-time staff, as well as a further 20 to 25 part-time staff, a West Dunbartonshire Council planning meeting heard last week. It will operate as a takeaway only and open at 11am before closing at midnight daily.
Councillors unanimously approved a planning application for two units at the premises to form a hot food takeaway and a class two (office, financial or professional services) unit, in which a tenant has not yet been identified.
Some of the elected members raised concerns over customers illegally parking outside the takeaway and causing traffic disruption.
An officer at the meeting said the parking there was strictly prohibited and said it was the responsibility of Police Scotland to enforce the restrictions.
Councillor Tommy Rainey said: “I would hope that we can do something about having police do something about enforcement.
“I don’t think for a minute that people will not park there. Across from the other side of that junction, there’s a Chinese restaurant and, right in front of that, there’s traffic lights and people park there regularly in front of the lights.
“We should ask the police to be a bit more vigilant to do something about parking on these bottlenecks in the High Street.”
One Bridge Street resident sent a letter of objection raising concerns over noise and smells coming from the premises.
In a report to councillors, planning officers stated: “The unit is currently occupied by a pet shop which has been at this location for at least 25 years.
“The unit has been the subject of a marketing campaign since early June and there has been no interest from retail operators.
“While the preference would be for this unit to remain in use as a shop, there are suitable alternative locations available in the retail core should it choose to relocate and there are an adequate number of units available for new retail businesses should they be looking for premises within Dumbarton town centre.
“The use of this unit as an office and hot food takeaway will make a positive contribution to the vitality and viability of the town centre.”
See more stories from the Lennox Herald.


The Slovak defense ministry has selected Finnish armored vehicle manufacturer Patria as the preferred contractor for its BOV 8×8 infantry fighting vehicle program.
Under the government-to-government contract between Slovakia and Finland, Patria will supply 76 IFVs at this stage of the program.
The contract for the AMVXP 8×8 vehicles is worth 447 million euros and includes including logistics, ammunition and infrastructure. The IFVs will feature Turra-30 weapons station and a 30 mm cannon.
The first of the vehicles could be delivered as early as next year. The new IFVs will replace the ageing fleet of Soviet-era BVP-1, BVP-2 and BVP M tracked combat vehicles currently in service.
The government decision was based on bids submitted at the end of 2021, as well as vehicle and weapon system tests carried out in February 2022. Patria’s offer was the best match to the requirements.
According to the Slovak defense ministry, the acquisition price alone represented 35% of the evaluation, technical specifications 30%, logistical support, i.e. the life cycle calculation of the technology had a weight of 10% while a quarter of the evaluation was the degree of involvement of the Slovak defense industry.
Patria was selected over Rheinmetall and BAE Systems, the other two companies that had confirmed they submitted proposals for the competition. It is unclear whether there were other bidders in the program, as Slovakia did not reveal the names of the competitors.
“This is the most advantageous comprehensive offer, which fully meets the technical and operational requirements of the Armed Forces of the Slovak Republic and is fully compatible with NATO systems. The new technology will replace infantry fighting vehicles that are at the end of their technical life, not to mention their declining operability in the period when the demands on the readiness of the Slovak Armed Forces are growing,” said Slovakia’s defense minister Jaroslav Naď.
“Patria is known for its successful technology transfer programs and is fully focused on the security of supply and long-term cooperation with Slovakia. The Armed Forces of the Slovak Republic will get state-of-the-art, modular, high-performance and robust armored combat Patria AMVXP 8×8 vehicles,” Hugo Vanbockryck, Patria’s senior vice president for market area Europe in Patria, commented.


At the helm of an 18-piece band, guitarist and composer Joel Harrison crafts a personal…
At the helm of an 18-piece band, guitarist and composer Joel Harrison crafts a personal and powerful plea for peace on his thematic nine-song release, America at War (Sunnyside). The 62-year-old New York native begins the album with “March on Washington,” conjuring the excitement as well as the threat of violence toward civil rights protesters advancing on the nation’s capital with acid-etched guitar lines and the menacing bottom notes of tubaist Ben Staap. Songs also tackle the wrongheaded justification for the invasion of Iraq (“Yellowcake”), the ongoing tragedy for both American troops and the civilian populations in the Middle East (“The Vultures of Afghanistan”) and the aftermath of nuclear destruction (“My Father in Nagasaki”), the last of which was inspired by Harrison’s father’s experiences as one of the first American soldiers to view up close the devastation of the Japanese city.
Harrison’s writing and arranging for the big band underlines his sentiments, driving home his point of view through the colors and textures of an ensemble featuring top players such as trumpeter Ingrid Jensen; trombonists Alan Ferber and Curtis Hasselbring; and saxophonists Stacy Dillard, Jon Irabagon and Lisa Parrot. Bassist Gregg August and drummer Jared Schong are the versatile rhythm team throughout, and Wilson Torres provides a variety of percussive touches on vibraphone, congas, bongos and bells. Harrison’s sonic — and editorial — voice remains a constant, whether he’s expressing the plight of a homesick soldier (a heartfelt cover of Tom Waits’ “Day After Tomorrow,” featuring the guitarist on vocals) or decrying the country’s failure to meaningfully deal with substance abuse (“Stupid, Pointless, Heartless Drug Wars”). The musical cycle doesn’t address what Harrison refers to in the liners as the current “struggle for the soul of our nation,” but he hints that he may tackle it in the future.


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I’ve noted many times via this blog that Latinos, women, and other minorities use community colleges as a pathway to four-year institutions. Unfortunately, this report by the American Association of Community Colleges indicates the pipeline is still very “leaky:”
More than half of U.S. Hispanic and Native American undergraduate students are enrolled in community colleges, and so are more than 40% of Black students and students of Asian and Pacific Islander origin.21 Yet completion rates for students of color in some groups—often those students facing the greatest challenges—are disappointing in the extreme: For example, one analysis indicates that 6 years after college entry, only 30% of low-income community college students, 26% of Black students, and 26% of Hispanic students have completed either a degree or a certificate, compared with 39% and 36% of White and high-income students, respectively. These blights threaten the American future and must be addressed.
The report provides suggestions for a new framework but it doesn’t seem ambitious enough to reverse the trend.
Check out this Economic Policy Institute Briefing on the economic challenges faced by workers at the bottom of the wage scale. The briefing provides the racial/ethnic composition and education levels of the low-wage workforce including what occupations have the highest and lowest shares of low-wage workers. According to the report, female, young, and minority workers are overrepresented in the ranks of low-wage workers. In regards to Latinos:
Likewise, Hispanics made up 15.3 percent of the workforce in 2011but constituted 23.6 percent of poverty-wage workers.
Why are college grads not finding jobs?
About 1.5 million, or 53.6 percent, of bachelor’s degree-holders under the age of 25 last year were jobless or underemployed, the highest share in at least 11 years. In 2000, the share was at a low of 41 percent, before the dot-com bust erased job gains for college graduates in the telecommunications and IT fields.
Out of the 1.5 million who languished in the job market, about half were underemployed, an increase from the previous year.
Take a few minutes to read through the comments via this article. The opinions range from rising college tuition costs to students that major in Liberal Arts. There’s obviously no clear reason but we’re again reminded that the United States’ economy and workforce is in transition.
Mariela Dabbah makes the point that many colleges and universities still don’t know how to increase Latino representation and graduation rates on their campuses. Many organizations, frankly, are clueless. Mariela explains:
The roundabout answers my question received from the four panelists – all Human Resource and Diversity leaders at top private universities – propelled a woman in the audience to insist that the panel circle back to my question after the conversation had moved in a different direction.
Judging from the panel’s reaction, it was obvious that they actually didn’t have an answer. Unfortunately, what also became apparent is part of the reason why so little has changed in the last few decades in terms of inclusion and retention of diverse students in higher education.
While Mariela argues that universities can learn lessons from some corporations on this issue, I think the examples of organizations that have solid track records in this regard are still lacking as well.
My good friend (and fellow scholar) Patti Fletcher shares excellent advice on the power of building relationships in the workplace. Her work in this regard focuses on the differences between women and men (transactional vs. transformational), but her thoughts are excellent tips for anyone looking to build a network for career success and leadership.
After decades of arguing they’re vital to the U.S. workforce, women remain wedged in the lower ranks of organizations. According to this study by the Center for American Progress, they’ve seen very little movement. For Latinas, it’s even lower:
$518—the median weekly earnings for Latinas compared to white women ($703), black women ($595), and Asian women ($751).
It’s one of the many reasons Latinas leave corporate America and are six times more likely than the national average to start a new business.
As a country, we all pay a steep price for this continued trend – or rather – reality. It’s a price that we cannot afford to pay for much longer.
Hispanic Business shares the Latina Woman of the Year – as well as other influential Latinas in business. Given the poor representation of Latinas in most organizations, it’s great to see Hispanic Business highlighting these incredible and inspiring women. And many more kudos to those that don’t get this type of notoriety!
Agree with David Morse at AdAge Blogs regarding variation in Latino identity over time. While different in many respects, there are cultural factors that bind Latinos together:
Central to that culture is a belief in hard work, the valuation of the Spanish language and at the top of the list, love of family. The art of developing targeted messages for Hispanics will evolve as the demographics of the population change. But it will take a lot more than three generations for marketing communications evoking these traditional Hispanic cultural pillars to lose their power.
Key point here is developing the key strategies – a moving target really since generational differences are not the same across Latino culture. Interesting stuff.
Excelencia in Education answers the question. Check out the exec summary here.
Interesting graphic via Sirona Consulting about where job seekers are getting their career information. First choice (company site) is obvious but social media platforms have been gaining ground the last two years. And by the way – I agree it’s more than a Facebook page or tweeting out jobs. Organizations need to have a strategic social media program in place for this to work because it’s the future – within and outside of the organization.
Are you listening?


Last week, the American Banker's Association announced that the number of credit card delinquencies had fallen to an 8-year low, with just 2.75% of all credit card payments coming more than 30 days late.
That's obviously good news for the average borrower - who by the way is carrying close to $5,000 in debt, last we heard - though there are other stats out this week that signal the delinquency rate could rise again if we're not careful.
But first, let's focus on the good news - delinquencies are in fact down across the board. That's a good job by you, America! Why exactly are late payments at an 18-year low? There are a lot of factors to consider, but perhaps the greatest is newfound transparency and education when it comes to debt.
Let's face it; over the last four years, a lot of us have found out the hard way how runaway debt can come back to haunt us. The silver lining, however, is that we're a lot more versed in what can deflate a credit score and ruin a reputation with lenders than we were just a half-decade ago. This had lead to a more rigorous interest in paying down our debt as best we can and making credit card payments - and other interest-laden bills - a priority in 2013.
Not to say we weren't aware that defaulting on a credit card payment was a credit killer pre-Great Recession - it's just now a lot more of us know just how costly a bad credit score can be in the grand scheme of things. By and large people have been more interested in austerity and frugality in general over the last few years, knowing just how bad things can get when the bottom falls out.
And yet, as Time reported last week and we're echoing here today, there's reason to believe that new consumer confidence in the economy - while strong - is pushing those credit card balances back up.
For instance, the Federal Reserve Bank of New York reported a $2 billion rise in debt in Q3; interesting considering that overall debt dropped by a full $74 billion. Odds are that debt jumped even more in Q4 when you consider holiday shopping. There are no definitive numbers out there confirming what many of us believe - that credit card debt will see a jump in Q4 of 2013 - but considering that the average American planned on spending 32% more on gifts than the previous year, according to the American Research Group, we would hardly be surprised to see even more debt in Q4 of 2012.
OK, we'll cease from speculating and wait for the numbers to come in. And who knows, maybe the new standard for credit card use will become high debt with a low delinquency rate? It's unlikely, but it's the current state of matters when it comes to credit debt in 2013.
For now, we'll keep our fingers crossed that default payments remain low in the coming months. The result could mean a stronger economy and lower interest rates, and frankly that's good news for all of us.


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domain: entertainment


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MARQUETTE, Mich. (WJMN) – September 19 through September 25 is Forensic Science Recognition Week.
Forensic Science Week recognizes the contribution that forensic science makes to the criminal justice system. The Eighth District Headquarters in Marquette is the Upper Peninsula’s only forensic laboratory for the Michigan State Police. There are six other locations in the state.
“So we have three units here at our laboratory,” said Zachary Blaksmith, laboratory manager of MSP’s Marquette Forensic Laboratory. “We have a biology unit that focuses on body fluid identification. We have a control substance unit which tests substances for drugs. And then we have a latent print unit which does fingerprint analysis. We also have a crime scene response unit here at the laboratory.”
Crime Scene Response Teams are on call 24 hours a day to document, process, and collect evidence at crime scene locations. The Marquette Forensic Laboratory provides services for local, state, federal, and tribal levels. Over the last decade, the lab’s caseload has doubled.
“The increase in drugs we’ve gone from 50 percent of submissions to the laboratory being drug-related, now they are 70 percent of the submissions. Also because of the CSI effect, prosectors and juries now require more forensic science evidence and more forensic processing,” said Blaksmith.
The lab’s drug cases have gone from about 600 samples to 1,200 samples in the past 10 years. The lab processes between 70 to 100 drug case samples every month.
- Which state has the most luxury cars?
- Graham warned to follow decorum rule after he attacks Democratic colleague
- Cheney: GOP is ‘very sick’
- Monkeypox vaccines: A virologist answers 6 questions about how they work, who can get them and how well they prevent infection
- Senate passes sweeping tax, climate package after marathon vote; Harris breaks tie

domain: law


HEALTHY FAMILIES: Amended Bill Would Use Tobacco Money to Insure Adults
Sen. Martha Escutia (D-Huntington Park) Tuesday amended a bill she had proposed so that it would use a portion of the state's tobacco settlement money to cover one million uninsured adults through Healthy Families, the Sacramento Bee reports. Escutia previously had proposed that the entire tobacco settlement be used to cover the uninsured, but Gov. Gray Davis (D) objected because he wanted the "flexibility to use the [settlement] money for other state needs." Escutia's new proposal would use part of the settlement money to expand the Healthy Families program to the parents of already enrolled children. Previously only uninsured children were eligible for the program, but "new regulations allow states to petition the federal government to enroll parents." By using the tobacco money to expand the program, the state would receive additional matching funds from the federal government, which now allocates $2 for every $1 the state contributes. The program's expansion is expected to cost between $115 and $130 million per year, while the total tobacco settlement is estimated at $450 million per year over the next 20 years.
Salvaging Lost Funds
Escutia's new proposal might solve another problem. Because of Healthy Families' low enrollment -- currently 323,000 children are enrolled -- California is likely to forfeit $590 million in "unused federal funds" next month, but Escutia hopes that by extending the program to working adults, the state can salvage some of that money. Escutia said that the bill is "just an opportunity we cannot pass up to throw away hundreds of millions of dollars while millions of California families still go without access to decent health care." While the state Department of Finance opposes the bill, a Davis spokesperson said that although the administration had not yet seen the amended bill, Davis "plans to review all options pertaining to Healthy Families money from the federal government" (Rojas, 8/24).


In order to realize the additional measurements for the external interfaces/services, our client is looking for an infrastructure specialist to strengthen the project team. The Infrastructure specialists works closely with the IT analyst, key-users of the external interface/service in the business, IT application support, IT service managers, the project team and project management
Analyze impact of existing interfaces/services that uses the software development environment when switching to the second availability zone and give advice/recommendation
Document for each interface the As-Is situation
Aligning with key-users and software engineers on new solution setup
Define requirements and create high-& low- level To-Be designs
Guarding overall quality delivered by the external interface/service owners
HBO+ or Academic level education
Minimal 5-10 years of relevant work experience
Relevant experience and proven experience in large technical complicated development environments
Solaris and/or Linux Infrastructure
Virtualizations techniques: Linux Red Hat Enterprise Virtualization or Solaris LDOM’s
Knowledge regarding management of large server and VDI environments
Base Knowledge of Storage solutions and databases
Strong verbal and written communication skills (English)
Good documenting capabilities
Able to handle issues from demanding customers in a professional way.
Shows initiative and problem solving attitude.
Pragmatic, practical, flexible (occasional evening or weekend work) and committed to quality.
During the project the Infrastructure specialist will work within complex application landscapes with multiple programming languages (e.g. Java, C++, Perl and Unix), interfaces and components per application.
The candidate has a hands-on mindset, strong customer- and problem solving orientation, shows fast results, and has demonstrated good communication skills, especially in an international IT organization. To achieve the project goals the candidate is able to liaise directly with all stakeholders. The candidate has a clear focus on results.
till Nov 2015 (with option to extend)
fulltime/40 hours a week
Are you interested in this position? Please sent us your motivation letter and resume in English in a Word Document. Please mention your hourly rate in your motivation.


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Terracotta pot "Mojave" + assorted plate
Pot in ceramic, made of a pink ocher clay, with lines on a black background, and a small assorted plate.
Made and painted by hand in our Parisian workshop, each flower pot is unique.
Our pot is pierced at the bottom, so you can re-pot your favorite plants directly in it.
It comes with an assorted small plate for water.
Height: approx. 10 cm
Diameter: approx. 10 cm
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