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Sec. Endovascular and Interventional Neurology
Volume 10 - 2019 | https://doi.org/10.3389/fneur.2019.00308
Endovascular Treatment of Acute Stroke Due to Intracranial Atherosclerotic Stenosis–Related Large Vessel Occlusion
- 1Interventional Neuroradiology, Department of Radiology, Severance Stroke Center, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea
- 2Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea
- 3Department of Neurology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea
Endovascular treatment (EVT) has become a standard treatment for acute ischemic stroke due to large vessel occlusion (LVO) in the anterior circulation. However, whether EVT tools used for intracranial atherosclerotic stenosis (ICAS)-related LVO are as safe and effective as for use in embolic LVO remains unclear. There have been only a few studies about EVT for ICAS-related LVO, and these studies revealed that mechanical thrombectomy with a stent retriever or contact aspiration was less effective and more time consuming in ICAS-related LVO than in embolic LVO. Because fast and successful recanalization (defined as modified Thrombolysis in Cerebral Ischemia grade, 2b or 3) is the most critical factor influencing favorable outcomes, it is important to determine the appropriate EVT strategy for fast recanalization of ICAS-related LVO. In this report, we review the results of mechanical thrombectomy using stent retriever or contact aspiration and rescue treatments after failure of mechanical thrombectomy for ICAS-related LVO. Finally, we propose the EVT strategy appropriate for ICAS-related LVO based on a literature review and our experience.
Endovascular treatment (EVT) for acute stroke due to emergent large vessel occlusion (LVO) has been successful, and EVT has become a standard treatment for LVO (1). The rate of recanalization, defined as modified Thrombolysis In Cerebral Ischemia (mTICI) grade 2b or 3, has been improving since the first 5 successful EVT trials, which demonstrated that higher recanalization rates are associated with better clinical outcomes (2–5). For mechanical thrombectomy, the two mainstay modalities are stent retriever (SR) and contact aspiration (CA) thrombectomies. Both methods were primarily invented for removal of the embolic clots occluding the large vessel. The pathomechanism of intracranial atherosclerosis (ICAS)-related LVO is likely due to in-situ thromboocclusion rather than embolic occlusion (6–8). The efficacy of both methods for recanalization of in-situ thromboocclusion in ICAS-related LVO has not been well elucidated. ICAS is one of the main causes of acute stroke in Asian, Hispanic, and African populations (9–11) and furthermore recent studies have documented that ICAS-related LVO is responsible for approximately 12–30% of all causes of LVO in East Asia (7, 8, 12–16). Therefore, it is worthwhile to investigate the efficacy of SR or CA thrombectomy and the most appropriate EVT strategy for ICAS-related LVO. This review aims to investigate on what are the problems in EVT and to find out the appropriate treatment strategy for ICAS-related LVO.
Outcomes of Endovascular Treatment for ICAS-Related LVO
Until recently, there have been only a few retrospective studies in which the clinical outcomes of EVT for ICAS-related LVO have been evaluated, and the results were inconsistent. In a study, patients with ICAS-related LVO had more favorable outcomes than patients with embolic LVO (15). In contrast, other researchers showed less favorable outcomes or no significant difference between the two groups (8, 14, 16–18). Notably, the rate of favorable outcomes was proportionate to the recanalization success rate. Successful recanalization and favorable outcome rates were observed more frequently in patients with ICAS-related LVO in a few reports, but the opposite was observed in a different study. In another study with similar recanalization rates, clinical outcomes were similar between the two groups (Table 1).
Table 1. Comparison of outcomes between intracranial atherosclerotic stenosis-related and embolic large vessel occlusion.
In a recent study, ICAS-related LVO was a worse prognostic factor in multivariate analysis although recanalization rates were similar between embolic and ICAS-related LVO groups. A significant interaction of underlying etiology (ICAS verse embolic) on patient outcome was observed with procedure (puncture-o-recanalization) time. Therefore, they suggested that “the relatively poor outcome in the ICAS-related LVO is mainly attributable to longer procedure time, reflecting the procedure complexity and the higher rate of reocclusion” (19).
From the results of the previous studies, we can infer that recanalization status and procedural time (puncture-to-recanalization time) are more relevant factors affecting patient outcomes than occlusion etiology itself (ICAS vs. embolic). In other words, if successful recanalization in the ICAS-related LVO was achieved as fast and with high rate as in the embolic LVO, functional outcome of ICAS-related LVO would be comparable to that of embolic LVO.
Endovascular Treatment for ICAS-Related LVO
Stent Retriever Thrombectomy for ICAS-Related Large Vessel Occlusion
SR thrombectomy is recommended as the first-line EVT modality for acute stroke due to anterior circulation LVO (1). SR thrombectomy for obtaining initial recanalization appeared to be as effective in ICAS-related LVO as in embolic LVO (6, 7, 12–16, 19). However, reocclusion during EVT is very frequent after an initial recanalization with SR thrombectomy in ICAS-related LVO, with reported ranges from 57.1 to 77.3% (6, 7, 12–16). For SR thrombectomy, a microwire should be passed through the occlusion site followed by a microcatheter with an inner diameter ≥0.021-inch. Although physicians may be concerned that passage of a microwire followed by a microcatheter is potentially dangerous, the initial SR attempt was successful in most ICAS-related LVO cases, and has not been reported to be difficult (6, 7, 13–15). However, once reocclusion occurs, repeated SR thrombectomy attempt seemed to be ineffective and prone to procedural complications because it may cause vessel injury, resulting in repeat reocclusion, spasm, and dissection (6, 7, 13–16, 20, 22, 23).
Although it has not yet been well known why reocclusion is so frequent in ICAS-related LVO, it can be explained by its pathomechanism and thrombectomy procedure itself. The pathomechanism of ICAS-related LVO, similar to that of coronary artery disease, is likely in-situ thromboocclusion due to unstable plaque rupture (6–8). An acute in-situ clot formed on an ICAS plaque is platelet-rich one (22). Repeat passages of a microwire, a microcatheter and SR may further damage the inflamed plaque and thus provoke more platelet activation and even arterial dissection (Figure 1) (6, 7, 21). Therefore, repeat attempts of SR thrombectomy should be avoided so far as possible once reocclusion has occurred in ICAS-related LVO (6, 7, 13, 14).
Figure 1. A schematic drawing of reocclusion mechanism after stent retriever or contact aspiration thrombectomy for intracranial atherosclerotic stenosis-related large vessel occlusion.
Contact Aspiration Thrombectomy for ICAS-Related Large Vessel Occlusion
Although first-line CA thrombectomy is as effective as SR thrombectomy in embolic LVO, it seemed less effective for recanalization of ICAS-related LVO. In a study that compared the efficacy of SR vs. CA thrombectomy in 146 ICAS-related LVO, the rate of switching to alternative thrombectomy technique (SR to CA thrombectomy or vice versa) after the frontline modality failed was significantly higher in the CA group (40%) than in the SR group (4.7%, p < 0.001) (21). Theoretically, a successful CA thrombectomy requires firm engagement of a large-bore catheter distal tip with the occluding clot. In ICAS-related LVO, the parent artery is likely to be tortuous in form and tapered to the occlusion site.
Therefore, the distal tip of a large-bore catheter is likely to less firmly engage the occluding clot in ICAS-related LVO than the embolic clot in a normal parent artery (Figure 1). Furthermore, the reocclusion rate of CA thrombectomy was similar to that of SR thrombectomy (8). In CA thrombectomy, a microcatheter and a microwire were navigated through the occlusion site and then a large-bore catheter is advanced over the wire and microcatheter to the occluding clot. Thus, the preceding passage of a microwire and a microcatheter may also irritate the inflamed plaque and eventually provoke more platelet activation in ICAS-related LVO.
As in the embolic LVO, fast and successful recanalization is the most important factor for achieving good outcomes in ICAS-related LVO. Therefore, if the primary thrombectomy failed to achieve recanalization, rescue treatments should be performed as soon as possible. Rescue treatments after failure of frontline thrombectomy for LVO include switching to another tool (SR to CA thrombectomy or vice versa), simultaneous use of both SR and CA thrombectomies, intraarterial thrombolytic infusion, intraarterial, or intravenous glycoprotein IIb/IIIa inhibitor (GPI) infusion and stenting with or without balloon angioplasty (6–8, 13–15, 18, 23–26). Because reocclusion in ICAS-related LVO is very frequent and most likely due to platelet activation, a severe degree of residual stenosis, or combined contribution of both, rescue treatment should be focused on platelet inhibition and alleviating the degree of residual stenosis. GPI has been suggested for platelet inhibition in the several previous reports. Intraarterial or intravenous infusion of low dose of GPI (Tirofiban, 0.5–1.5 mg or Reopro, 3–10 mg) was effective for resolution or prevention of re-occlusion of ICAS-related LVO (7, 8, 14) (Figure 2). GPI could make the endothelium more stable, which could reverse the in-situ thrombotic reocclusion tendency (6, 7, 14, 22). In our center, intra-procedural administration method of GPI is typically as follows; angiogram is obtained every 10 min at least 2 times after administration of 0.3–0.5 mg of Tirofiban (or Reopro, 3–5 mg). If reocclusion (tendency) is not resolved, additional 0.3–0.5 mg of Tirofiban (or Reopro, 3–5 mg) is administered up to 1.5 mg (or Reopro, 10 mg) until reocclusion (tendency) is resolved (or improved antegrade flow velocity) on angiogram obtained every 10 min. The dose of GPI did not depend on whether or not to use intravenous tPA administration.
Figure 2. A schematic drawing of rescue treatment for reocclusion after initial recanalization of intracranial atherosclerotic stenosis-related large vessel occlusion.
Rescue stenting and/or angioplasty is an another (or additional) option for resolving reocclusion. As well known, a severe degree of focal stenosis is an important factor that provokes clot formation. Therefore, by alleviating the underlying severe degree of stenosis, rescue stenting and/or balloon angioplasty is likely to play a role in preventing reocclusion or in recanalization for such cases that are never opened with mechanical thrombectomy (24, 25) (Figure 3). In literature, it seemed to depend on operators' preference whether to do stent alone, stent with pre- or post-stent balloon angioplasty, or balloon angioplasty alone (6, 17–19, 24, 25). It also depended on operators' preference to use what kind of stent. However, self-expanding stent seemed to be favored rather than balloon-expandable stent. In addition, of the self-expanding stent, Solitaire-FR stent rather than Wingspan stent seemed to be favored for rescue stenting. It is likely because Wingspan stent requires additional preparation time and more technical demands for delivery, whereas it seems simple to detach a Solitaire-FR that was already in using for thrombectomy (6, 24, 25).
Figure 3. Comparison of modified Rankin scale score among mechanical thrombectomy success, rescue stenting, and non-stenting groups. MT, mechanical thrombectomy.
Recent two studies compared patients who received rescue stenting with those who was left without further treatment after mechanical thrombectomy failure. Rescue stenting group showed better functional outcome than non-stenting group (24, 25). Patients with recanalization success showed a similar distribution of mRS at 3 months, regardless of recanalization methods (mechanical thrombectomy or rescue stenting) (Figure 3). In those studies, the majority of patients with rescue stenting had ICAS-related LVO. Therefore, rescue stenting may be a rescue method in ICAS-related LVO. Another recent study also have demonstrated that both GPI and rescue stenting are similarly effective and safe in ICAS-related LVO (23).
Postprocedural delayed reocclusion also worsen patients' functional outcome (25, 26). Timing and maintenance of postprocedural antiplatelet medication is important to prevent postprocedural reocclusion. Although there has not been controlled study, intravenous infusion of GPI with maintenance dose for a 6–12 h after completion of EVT and then change to oral antiplatelet medication has been proposed (14). The degree of residual stenosis may be an another factor for post-procedural reocclusion. It has not yet been studied whether rescue stenting and/or angioplasty is needed to prevent postprocedural delayed reocclusion. However, if the degree of stenosis is very severe, alleviating the stenosis by rescue stenting and/or angioplasty may be helpful in both instant and delayed reocclusion. It should be addressed if rescue stenting and/or angioplasty is helpful for preventing postprocedural delayed reocclusion.
It has yet remained unclear whether stenting combined with anti-thrombotic drug is safe in acute stroke setting. In recent reports, however, intracranial or cervical carotid artery stenting with use of antithrombotic medication in acute stroke setting did not increase the development of symptomatic intracranial hemorrhage, while significantly improved functional outcome (24, 25, 27). Because of retrospective nature of these studies, the type and mode of antithrombotic medication combined with stenting varied depending on centers; (1) intra-arterial or intravenous loading of GPI followed by maintenance of 6–12 h, then changed to oral dual antiplatelets, (2) loading dose of oral dual antiplatelets just before or after rescue stenting (aspirin 85–500 mg and clopidogrel 300 mg), (3) oral mono antiplatelet (clopidogrel, 75–300 mg), and (4) no antiplatelet medication until follow-up CT or MR on the next day (24, 27). When GPI and rescue stenting which requires antithrombotic medication is applied in acute stroke setting, the most feared concern is possibly increased risk of intracranial hemorrhage. In recent multicenter studies, however, intracranial or cervical carotid stenting combined with use of antithromboics drugs in acute stroke setting did not increase the development of symptomatic intracranial hemorrhage whereas significantly improved functional outcome (24, 25, 27). In our experience, it seems very helpful in decision making to obtain flat-panel CT before GPI infusion and/or rescue stenting. Although a specific criterion of unfavorable candidate for GPI and/or rescue stenting has not yet been recommended, we have not done further treatment for cases that have large area of contrast material enhancement on flat-panel CT. In this strategy, the rate of symptomatic intracranial hemorrhage was not higher in patients with GPI and/or rescue stenting than in patients without (7, 14, 24, 25).
Endovascular Strategy Appropriate for ICAS-Related LVO
Recanalization status and procedural time are more relevant factors affecting patient outcomes than occlusion etiology. For faster and more successful recanalization, identifying underlying ICAS as the cause of LVO and setting an optimal strategy for ICAS-related LVO are key factors leading to better clinical outcomes in ICAS-related LVO patients. Before starting EVT, the following markers may suggest ICAS-related LVO from embolic LVO: (1) the absence of atrial fibrillation on echocardiogram and (2) absence of hyperdense artery sign on CT or susceptibility (blooming) artifact sign on MR gradient echo image, and (3) truncal-type occlusion on CTA. During the EVT, (1) a truncal-type occlusion and (2) a remnant (fixed focal) stenosis after initial recanalization at the occlusion site are suggested as useful surrogate markers of ICAS-related LVO (Table 2). It is critical to determine when to introduce what kind of rescue treatment after failure of mechanical thrombectomy in ICAS-related LVO. Procedural time in the ICAS-related LVO was consistently longer than in the embolic group across the all previous studies (7, 8, 12–16, 20, 21), and this can be explained by repeat SR or CA thrombectomy attempts before applying the appropriate rescue treatment for ICAS-related LVO (7, 12, 14, 19). If the appropriate EVT strategy for ICAS-related LVO can be set early (before starting EVT, if possible), operators can shorten the puncture–to-recanalization (procedural) time as well as increase recanalization rate, thus providing a better clinical outcome (6, 7, 14, 19). Rescue stenting and/or balloon angioplasty, intra-arterial or intravenous GPI infusion, or combination of those have been reported as appropriate treatments for ICAS thrombo-occlusion (7, 8, 14, 15, 18, 23, 23–25). The stepwise approach in using such modalities in addition to mechanical thrombectomy is likely helpful in faster and more successful recanalization of ICAS-related LVO.
Table 2. Surrogate markers suggested of intracranial atherosclerosis-related large vessel occlusion.
From practical point of view, a microcatheter with inner diameter 0.021-inch may be less difficult in delivery to the target lesion of ICAS-related LVO than a large-bore aspiration catheter because the relevant parent artery is likely more tortuous in ICAS-related LVO than in embolic LVO. Furthermore, SR is better to detect ICAS-related LVO by showing occlusion type (truncal or branching-site) as well as to obtain first-pass recanalization (Table 3). Therefore, SR thrombectomy is recommended as frontline modality if ICAS-related LVO is suspected. After achieving initial recanalization, a follow-up angiogram should be obtained every 10 min at least up to 30 min for detecting reocclusion (tendency). If reocclusion occurs with mild-to-moderate degree of residual stenosis after initial recanalization, GPI should be first recommended for avoiding acute stenting so far as possible. Whereas, if recanalization is never obtained or if reocclusion appears due to a severe degree of residual stenosis, rescue stenting and/or balloon angioplasty may be considered (Figure 4).
Figure 4. The stepwise endovascular strategy appropriate for intracranial atherosclerotic stenosis-related large vessel occlusion. ICAS, intracranial atherosclerotic stenosis; LVO, large vessel occlusion; GRE-MR, gradient echo magnetic resonance imaging; HAS, hyperdense artery sign; NECT, non-enhanced computed tomography; TTO, truncal type occlusion; CT, computed tomography; SR, stent retriever; GPI, glycoprotein IIb/IIIa inhibitor.
Although there has been no well-controlled study yet, rescue stenting and/or GPI use may be recommended as a rescue endovascular strategy appropriate for ICAS-LVO with never recanalization or repeat reocclusion. A prospective study is needed to find most appropriate endovascular strategy for ICAS-related LVO.
Recanalization success and puncture-to-recanalization (procedure) time are two important procedural prognostic factors in ICAS-related LVO. With similar recanalization rate and procedure time, clinical outcome of ICAS-related LVO would be comparable to that of embolic LVO. For obtaining successful recanalization in ICAS-related LVO as fast and with high rate as in embolic LVO, the specific EVT strategy appropriate for ICAS is needed.
BK established the study idea, designed the manuscript structure, acquired and analyzed the data, and wrote the manuscript. J-HB and HP established the study idea, designed the manuscript structure, and made critical revisions to the manuscript with substantive intellectual content.
This research was supported by a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HC15C1056).
Conflict of Interest Statement
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
The authors thank MID (Medical Illustration & Design), a part of the Medical Research Support Services of Yonsei University College of Medicine, for all artistic support related to this work.
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Keywords: acute stroke, large vessel occlusion, intracranial atherosclerosis, endovascular treatment, stenosis and cerebrovascular occlusion
Citation: Park H, Baek J-H and Kim BM (2019) Endovascular Treatment of Acute Stroke Due to Intracranial Atherosclerotic Stenosis–Related Large Vessel Occlusion. Front. Neurol. 10:308. doi: 10.3389/fneur.2019.00308
Received: 15 September 2018; Accepted: 11 March 2019;
Published: 02 April 2019.
Edited by:Osama O. Zaidat, St. Vincent Mercy Medical Center, United States
Reviewed by:Yang-Ha Hwang, Kyungpook National University, South Korea
Seong-Joon Lee, Ajou University, South Korea
Mohammad El-Ghanem, University of Arizona, United States
Copyright © 2019 Park, Baek and Kim. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Byung Moon Kim, firstname.lastname@example.org

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NOTE: The numbers cited in parentheses, e.g. I 1:5, refer the researcher to the Group# Series#:Folder# in which that name/topic will be found.
The Charles A. Farrell Family Papers consist of business records, financial and legal documents, printed material, manuscripts, correspondence and photographs relating to the personal lives, ancestry and creative activities of Anne and Charles Farrell, as well as their sons Charles Burton, Peter and Roger Farrell. The collection also documents the Farrells’ ownership and operation of the Art Shop and the Book Shop in Greensboro during the early to mid-20th century.
Charles and Anne Farrell were both talented photographers who captured many images of people and places in Greensboro and throughout North Carolina between the mid-1920s and mid-1940s. The Archives also owns an Art Shop Photograph Collection containing several thousand images produced by the Farrells, and additional collections of their images are at the North Carolina State Archives and the University of North Carolina at Chapel Hill.
Arrangement: This collection is arranged into three groups by contextual origin and within each group by subject or format. The three groups are: Business Operations, 1940-1960 [bulk 1942-1955]; Family, 1916-1978; and Photographs, 1920s-1968.
Provenance: This collection was donated by Roger H. Farrell in December 2006 and assigned the accession number 2006.40.1.
Processing: This collection was organized by volunteer Alice Bailey, and the finding aid was completed in January 2014. In June 2018, the biographical note was updated by Archivist Elise Allison with information from the obituaries of Peter and Roger Farrell.
Charles Anderson Farrell (1893-1977) was born in Yadkin County, North Carolina, and grew up in Winston-Salem, where his father, photographer Andrew Jackson Farrell (1860-1924), operated studios from around 1897 into the 1920s. Charles attended Wake Forest College from 1910 to 1913, and then worked at his father’s studio before being hired by Eastman-Kodak as a sales and technical representative in Rochester, New York, and Mexico City. He enlisted in World War I and was assigned to Fort Sill but never saw action. In 1921, he married Anne McKaughan (1895-1977), whom he had met while teaching English at State College eight years earlier. The couple moved to Greensboro in 1923 and established the Art Shop, a photographic studio, camera store, and art supply house. Charles simultaneously worked as a freelance photographer for the Greensboro Daily News and contributed photographs for books, including Tobe by Stella Gentry Sharpe (UNC Press, 1939).
Charles and Anne traveled throughout North Carolina during the 1930s taking photographs and kodachrome videos. Charles captured some of the first aerial photographs in the state and also took pictures at the first performance of The Lost Colony in Manteo. During the late thirties, he took many photographs of workers in the fishing industry along the North Carolina coast; a book was planned but never finished due to illness. He was a close friend of W.B. Keziah, a deaf newspaper editor in Southport, North Carolina, and learned sign language to communicate with Keziah, to whom some items in the collection pertain. During World War II, Charles spent most of his photographic supply rations on paper to make prints for soldiers stationed in Greensboro. In 1948, he was hospitalized and ultimately received surgery. Afterwards, his photography career over, he was considered an invalid by the state and required care from a private nurse, but he remained socially active and mobile.
Anne Farrell was born in Enfield, North Carolina, in 1895. Her father was a Baptist minister, and she attended Meredith College from 1910 to 1914. In 1915 she was awarded a fellowship to Radcliffe, but a family illness forced her to discontinue a year later. After her marriage to Charles Farrell in 1921, she gave birth to Charles Burton (“Charles B.” or “Lito”) in Rochester, New York, followed by Peter and Roger, both in Greensboro. She began working at the Art Shop in 1935, and was particularly talented at photofinishing and helping customers select frames. During the early 1940s, she wrote and took photographs for two articles in American Girl and edited photographs for several books. In 1942 she opened the Book Shop, which was plagued by financial difficulties and sold in 1947. After her husband’s hospitalization, she assumed his duties at the Art Shop, which lost most of its capital when he withdrew a large sum of money during the onset of his illness. In 1960 the Art Shop was declared bankrupt and sold to Charles’ sister, Mary Farrell Hedrick. At this point Anne ceased to be professionally active as a photographer, although she remained interested in the subject. Both Anne and Charles died in 1977.
Charles B. Farrell (1922-2002) attended Curry Demonstration School, as did both his brothers. He was interested in music from a young age and collected classical music records during adolescence. He graduated with honors from Guilford College and worked as a librarian in the Music Library at UNC for a short time, but was dismissed from both the university and library. He was drafted in 1943 and served as company clerk and leader of a mortar crew. After the war he received a Bronze Star. Charles B. lived in New York City for most of his life; he worked primarily in graphic design, book design, and publishing. After his parents died, he purchased the family home at 308 Woodlawn Avenue with the intention of retiring to Greensboro, but never did.
Peter Farrell (1924-2018) was interested in music from a young age and showed proficiency with many instruments, favoring the violin. After an arm fracture at age 13, he was unable to continue violin and reluctantly learned to play the cello. During his adolescence, he was often away from home attending music camps and performing in youth symphonies. In 1943 he was drafted and served in the USO, and in 1946 he married Miriam “Mimi” Mellott, whom he had met at a music camp in Michigan. Peter and Mimi both attended Eastman School of Music in Rochester, New York, and Mimi was awarded a Bachelor of Music with distinction in 1946. Peter graduated with distinction in 1948 with a Performer’s Certificate and Bachelor of Music, and then received a master’s in music theory in 1953. Afterwards, he played cello professionally and taught at the University Illinois before joining the faculty of the University of California San Diego in 1972. After his retirement in 1991, he played cello in the La Jolla Symphony.
Roger H. Farrell (1929-2017) was born in Greensboro and at age 14 entered the University of Chicago, from which he earned a PhB (the equivalent of a bachelor’s in liberal arts) in 1947 and a master’s degree in mathematics in 1951. During the Korean War, he served as an analyst who evaluated where incoming personnel would be best suited to serve. He received his PhD from the University of Illinois in 1959 and taught in the Mathematics Department at Cornell University until retiring in 1999. Most of his research focused on mathematical statistics and measure theory, and he produced 34 research papers and two textbooks, Techniques of Multivariate Calculation (1976) and Multivariate Calculation: Use of the Continuous Groups (1985).
Biographical Sources: This biographical note was compiled from materials composed by Roger Farrell in 1977 and 2005 regarding members of the Farrell family and both the Art Shop and Book Shop. Other sources include items within the collection, correspondence from Roger Farrell to former Archivist Stephen Catlett, the finding aid for the Charles A. Farrell Photograph Collection at the North Carolina State Archives, and the campus obituaries of Peter and Roger Farrell (see the first folder in the collection for hard copies).
SCOPE & CONTENT NOTE
This collection contains items pertaining to the personal lives, creative endeavors and business activities of Anne and Charles Farrell and their son Roger Farrell. Its greatest strength is the photographs, most of which show areas in Greensboro and the Piedmont between the 1930s and 1960s; especially notable are images of Greensboro’s downtown area that record commercial development over a long period of time. Items in the Photography group reflect technical and stylistic changes in photography between the 1930s and 1950s, but the historical value of some is diminished by the absence of information about the creator, location and date. In some cases, the context of items is provided in emails from Roger Farrell to Stephen Catlett.
The primary source documents found in the Family group are also noteworthy. Charles’ reminiscences of his childhood and adolescence, dictated to Anne, narrate his experiences in detail. The correspondence of Anne, Charles and Roger constructs a portrait of the events and relationships that influenced their lives, and contains valuable insights into the mid-20th century American middle-class family. Researchers studying how families responded to prolonged mental illness during the mid-20th century will find this series interesting.
The records from the Art Shop and Book Shop in the Business Operations group provide insight into the supply and demand for photography supplies, framing services and printed materials in Greensboro during the early to mid-20th century. Some Business Operations material and correspondence from Anne will be valuable to researchers studying women entrepreneurs during the mid-20th century.
Weaknesses of the collection include a scarcity of information about Peter and Charles Burton Farrell, and a lack of biographical source material about Anne before her marriage. Also lacking is background information about Reverend George E.C. Knapp of England, with whom Anne corresponded for several years in the 1960s.
I. Business Operations
1. The Art Shop. 4 folders (ca. 20 items). 1940-1960.
This series consists primarily of financial documents such as annual reports, receipts, inventories and tabulations of payments due from customers. Also found are official documents from the Photographer’s Board of Examiners and correspondence relating to the sale of the Art Shop. Group II contains further correspondence from Anne Farrell to her son Roger, including letters regarding the sale of the Art Shop.
2. The Book Shop. 5 folders (ca. 120 items). 1943-1948.
This series includes correspondence relating to orders and outstanding balances, offers from solicitors, and Bennett Mitchell’s sale of the Book Shop to Anne. Correspondence and legal documents regarding reparations for orders damaged in transit to the Book Shop are found under legal disputes. Various business documents record accounts and inventories for both the Book Shop and Art Shop.
1. Farrell, Anne. 8 folders (ca. 110 items). 1920s-1960s.
Documents in this series relate to the professional activities and personal relationships of Anne Farrell. Materials pertaining to two articles Anne wrote for American Girl include correspondence, manuscripts and magazines. A collection of Christmas cards made by Anne between the 1920s and 1940s are of potential interest for their artistry and representation of the Farrell family at different periods. Individual income tax returns span from 1935 to 1955. Also included is a collection of correspondence from Reverend George E.C. Knapp, whose exact relationship with Anne is not known.
2. Farrell, Charles. 9 folders (ca. 175 items). 1936-1978 [bulk 1940s, 1960s].
This series contains newspaper clippings covering a wide range of subjects, including the fishing industry on the North Carolina coast and W.B. Keziah, a deaf newspaperman with whom Charles was friends. Of greatest interest are Charles’s reminiscences, which are detailed accounts of his personal experiences between the late 1890s and 1920, with some coverage after 1920. Subjects include Charles’ family, Wake Forest, World War I, Eastman Kodak, the stock market crash, and many locations in and around Greensboro. There are sparse notes on the chronology of events and an index of questionable accuracy, however these documents are possibly the most historically valuable items in the collection. Legal documents relating to Charles’s death and Roger Farrell’s management of his estate are also found in this series.
3. Farrell, Roger. 4 folders (105 items). 1932-1960s [bulk 1960s].
In addition to telegrams, performance programs and report cards from Roger’s attendance at Curry Demonstration School, this series contains correspondence from Anne, Charles, Charles Burton and Peter Farrell, as well as a selection of Charles’ reminiscences about events in Roger’s life.
4. Miscellaneous. 7 folders (55 items). 1916-1960s [bulk 1960s].
The highlights of this series are black and white photographic reproductions of art related to Historic New Garden. Also included are genealogical documents of the Farrell, McKaughan, Coe and Snow families, an issue of New York American, and newspaper clippings on a variety of subjects, including the Catholic and Episcopal churches.
1. Greensboro. 8 folders (80 items). 1920s-1967.
Of particular importance in this series are photographs of downtown Greensboro, focusing on the intersection of West Market Street and Elm Street. These include a series of this area after a heavy snowfall. Other items include photographs and negatives of Hamilton Lakes and the Katydid estate. In 1:4 are Anne’s notes for an artist’s conception of the Dolley Madison House at New Garden, accompanied by negatives of comparable structures, and the smokehouse constructed with logs from the original cabin. Several images of items from Dolley Madison’s wardrobe on display at the Greensboro Historical Museum are also of interest.
2. Miscellaneous. 3 folders (75 items). 1920s-1968.
Miscellaneous photographs and negatives include images of Montpelier, Monticello, and Oak Ridge; most of these images were likely taken by Anne Farrell.
3. Portraits. 2 folders (33 items). 1920s-1967.
This series contains photographs mainly of Anne and Charles Farrell, the latter represented in both formal studio portraits and candid poses beside an airplane shortly after he took the first aerial photographs of Greensboro. Photographs of various unidentified subjects are also included.
|I. BUSINESS OPERATIONS|
|1||1||Art Shop||-- Annual Reports (1949, 1952)|
|2||-- Photographer's Board of Examiners certificate (1940-1942)|
|3||-- Financial (1940s)|
|4||-- Sale of Art Shop (1960)|
|2||1||Book Shop||-- Correspondence from sale of Book Shop (1948)|
|2||-- Financial (1943-1948)|
|3||-- Legal disputes (1946)|
|4||Book Shop||-- Miscellaneous (1943-1948)|
|5||-- Records from sale of Book Shop (1948)|
|1||1||Farrell, Anne||-- American Girl, "Brookgreen Gardens..." (1940)|
|2||-- American Girl, "A Day in..." (1942)|
|3||-- Christmas cards (outgoing, 1920s-1940s)|
|4||-- Clapp, Millie (1965)|
|5||Farrell, Anne||-- Correspondence (1943-1968)|
|6||-- Income tax (1939-1955)|
|7||-- Knapp, Reverend George E.C. (1936-1969, bulk 1960s)|
|8||-- Personal (1944, 1955)|
|2||1||Farrell, Charles||-- Correspondence (1946-1955, bulk 1946-1947)|
|2||-- Invitations (1940s-1970)|
|3||-- Keziah, W.B. (1938-1954)|
|4||Farrell, Charles||-- Legal & financial (1971-1978)|
|5||-- Personal (1936-1971, bulk 1940s)|
|6||-- "Reminiscences," index & chronology (1960-1961)|
|7||Farrell, Charles||-- "Reminiscences," transcript (1960-1961)|
|8||-- "Reminiscences," transcript (1960-1961)|
|9||-- "Reminiscences," transcript & chronology (1960-1961)|
|3||1||Farrell, Roger, A.||-- Correspondence (from Anne Farrell, 1959-1967)|
|2||-- Correspondence (1947-1964)|
|3||-- Personal (1932-1960s)|
|4||-- Report cards (1940-1947)|
|4||1||Miscellaneous||-- Catholic and Episcopal Churches|
|2||-- Ephemera (1969)|
|3||-- Genealogy (1960s)|
|4||-- Historic New Garden|
|5||Miscellaneous||-- Newspaper, New York American (1916)|
|6||-- Newspaper clippings (1950s-1960s)|
|7||-- Operations report (1945)|
|1||1||Greensboro||-- 304 Woodlawn Avenue|
|2||-- The Art Shop (1920s-1960)|
|3||-- Dolley Madison exhibit (Greensboro Historical Museum)|
|4||-- Dolley Madison House & Ballinger Smokehouse (1966-1967)|
|5||Greensboro||-- Downtown street scenes (ca. 1925-1960)|
|6||-- Hamilton Lakes|
|7||-- Katydid estate (McConnell Road, 1939)|
|8||-- Sesquicentennial parade (1958)|
|2||1||Miscellaneous||-- Montpelier & Monticello (1968)|
|2||-- Oak Ridge (1938)|
|3||-- "Passing of the..." James Whitcomb Riley|
|3||1||Portraits||-- Farrell, Charles & Anne (1935-1967)|

domain: library


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New Zealand reached an enviable milestone lately. in step with media research, a in the neighborhood-got case of coronavirus was once last mentioned larger than 100 days prior to now. in numerous words, New Zealand has mainly overwhelmed COVID-19 (for n0w) and has resumed a lot of its pre-2020 spare time activities. in the meantime, totally different countries just like the U.S. proceed to combat with coronavirus. New Zealand’s distinguished success is a win for science. alternatively, its geography moreover played a job.
beforehand of I dive into the geography, it is an important that I applaud New Zealand’s savour for science and public neatly being experience. They answered to science guidance early throughout the route of. top Minister Jacinda Ardern mentioned that her u . s . had to”go arduous, and go early,” in keeping with CNN. the united states had a naturally recognized national strategy early on, and its COVID-19 method website online says that their removing technique is a sustained effort. Their manner, consistent with the website is “controlling entry on the border; sickness surveillance; bodily distancing and hygiene measures; testing for and tracing all doable cases; setting apart circumstances and their close contacts; and broader public health controls relying on the alert stage we’re in.” a latest study within the New England Journal of medicine bureaucracy the success story of latest Zealand’s attack on coronavirus.
If you wish to have proof of how aggressive New Zealand was once with coronavirus, learn this directive from the high Minister on March 14th, 2020. whereas the U.S. was once additionally beginning to ramp up its efforts, many critics introduced up the gradual response and ideological narratives within our america. on the similar degree inside the U.S., many individuals have been on the other hand conversing about hoaxes, enjoying the blame sport, or calling it “merely the flu.” all the way through the method, Dr. Anthony Fauci and infectious disease experts really helpful urgent, sustained and aggressive actions. for individuals who study New Zealand’s case charge to the U.S. (beneath), there are definitely adaptations which can be more than likely associated to early movement, warning in re-opening, less conspiracy notion ideology and a coordinated nationwide strategy. on the other hand, New Zealand’s unique geography moreover carried out a role.
How Geography Helped New Zealand Beat Coronavirus
actually useful For You
New Zealand, infrequently known as Aotearoa New Zealand, is made of two massive islands known as the North and South Islands. most people live on the North Island. There are also smaller islands, most significantly the Chatham Islands and Stewart Island. when it comes to bodily geography, the United States is situated in the southwest Pacific Ocean and is regarding the dimension of the uk or Japan, in step with a governmental site. as a result of its space on the boundary of the Indo-Australian and Pacific tectonic plates, volcanic and earthquake job has fashioned the landforms of the us of a. Over sixty seven% of the United States is mountainous to hilly terrain.
because of New Zealand is an island, it had some inherent advantages that helped with the struggle in opposition to COVID-19. with out a land-primarily based totally entry points, the U.S. has an more uncomplicated time monitoring who is available in and abroad. The mountainous terrain also limits where individuals reside. should you occur to take a look at the topographic map at first of this text and overview it with the place other people reside (below), you see what i am speaking about. consistent with the brand new Zealand govt website online, population density is low – “….with a neighborhood of 271,000 sq. kilometres….as a result, its inhabitants density is rather low, at 15 individuals per sq. kilometre – decrease than 1/2 the OECD reasonable and better than only Australia, Iceland, Canada and Norway.” with the aid of using comparability, the U.S. has 275 folks per sq. kilometer.
whereas geography and inhabitants without doubt performed a job within the US’s success with coronavirus, you will need to end with this reminder. admire for and response to science steering is certainly the outlet chapter in the e-e book about how New Zealand limited the influence of coronavirus.

domain: geography


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Anzio Port- West
There are two memorials at this site: both plaques located on nearby buildings, remembering units that participated in the Anzio operations.
Via Porto Innocenziano, 13 00042 Anzio (RM) , 00042 , Anzio , Roma , Lazio , Italy
Located in the Port of Anzio, referred locally as “Porto-West” (West-Port). The site is located on the waterfront road, Via Porto Innocenziano. The port is located a short walking distance from downtown Anzio and the site located in an area of shops, restaurants and Coast Guard (Guardia Costiera) and Financial Guard (Guardia di Finanza) buildings.
Map reference (click on pin to see Lat/Long):
41.4455 12.6303 Via Porto Innocenziano, 13 00042 Anzio (RM)
Flag Poles :


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Healthy (but delicious) Carrot Cake
mmmm, just look at that picture of our healthy carrot cake. It looks so naughty, and we can tell you that the icing has just enough crystallisation to feel like a very-bad-for-you cream cheese icing.
Bake one of these for a work birthday and you’ll be a hit. Not only does it taste good enough the new guy will love it, but it will be so healthy that the perpetual dieter can have some without kick starting a 2 day food bender. Seriously, try it. It will be weird because you’ll want a second slice, but you won’t have to have that dollop of guilt with it.
- 2 medium carrots (grated)
- 1 cup tapioca starch
- 1⁄2 cup coconut flour
- 1 tsp baking powder
- 1⁄2 tsp ground cinnamon
- 1⁄2 cup coconut sugar
- 3/4 cup coconut oil
- 1⁄2 cup coconut nectar
- 3 eggs
- 1 tsp vanilla essence
- 1⁄2 cup roasted pepitas
- 180g creamed goats cheese (same consistency as cream cheese)
- 1⁄4 cup coconut nectar
- 1⁄4 tsp pure vanilla essence
- Preheat oven to 180°C.
- Grease a small round cake tin lightly with some coconut oil and line with non- stick baking paper.
- Mix all ingredients except carrots and pepitas in a large bowl or blender.
- Now gently stir in grated carrot and pepetis.
- Scoop the mixture into the cake tray. Filling it to the top as your cake will not rise much
- Bake for 35 – 40 mins
- Set aside to cool for about 10 minutes
- turn out onto a wire rack to cool completely
- place the goats ‘cream’ cheese, coconut nectar and vanilla in a bowl.
- Use a wooden spoon to mix until well combined
- Spread the icing over the cooled cake (and lick your fingers clean…)
Nutrition comparison vs Coles carrot cake (for a big slice like in the photo = 8 slices per cake)
This Healthy Carrot Cake recipe comes from Healthy Junk 2

domain: food


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Social Security: By the Numbers
Here are five facts about Social Security that might surprise you.
Have A Question About This Topic?
There are numerous ways to supplement your Medicare insurance coverage. This article helps you explore your options.
Even the most seasoned investors have biases affecting their financial choices.
Disability happens to more people, more often than you may think, and it lasts longer, too.

domain: economics


text:
Healthy benefits of peanuts to our body that we should know
Peanuts can be found easily around the stores and almost available in the entire world. They are being consumed as snacks in a lot of households. Even though in reality, peanuts are actually legumes due to its properties such as almonds, cashew, nuts and the like. It is also included in the family of nuts.
Here are the 12 benefits that you can get from peanuts:
- It is good for the heart
Peanuts contains a high level of monounsaturated and polyunsaturated fats that has the ability to maintain a healthy heart. Moreover, peanuts are consist of oleic acid that lessens bad cholesterol and increases good cholesterol in human body.
- Increases energy
Peanuts are widely known because of its ability to boost energy. Peanuts are consist of a huge number of vitamins, minerals, antioxidants and nutrients that are most important source of energy.
- It helps in weight loss
Peanuts have been studied in related to the maintenance of weight. It has a lot of calories and fats but it does not affect the increase of the body weight.
- Fights cancer cells
It is consist of polyphenolic antioxidants that is beneficial in stopping gastric cancer and it can also help in lessening the production of carcinogenic nitrosamines.
- Prevents gallstones
It is said that gallstones can actually affect between 10 to 25 percent of adults in the entire world. Regular consumption of peanuts can effectively lessen the chance of having gallstones. Studies have shown that only 30 grams of peanuts a day can help you in decreasing the risk of having this condition by 25%.
- Improves memory
Peanut are usually called as the “brain food” due to its Vitamin B3 that is extremely excellent for brain function as well as to improve memory.
- Fights against depression
Serotonin is a chemical that is indeed significant for the brain that can actually help in regulating the mood. Luckily, the amino acid tryptophan that can be found in peanuts may help in releasing serotonin that is why peanuts are also great in the prevention of depression.
- Supports pregnancy and protects the baby
Eating peanuts during pregnancy can also decrease the chance of some common allergic illnesses just like asthma in children.
- Prevents Alzheimer
According to a lot of studies, consuming foods that contains a huge amount of niacin just like peanuts can reduce the chance of having Alzheimer disease by at least 70%.
- Makes the skin radiant and toned
The ingredients that can be found in peanuts has the ability to make the skin shiny and bright. Moreover, the dietary fiber that it contains can help the body in getting rid of extra toxins that makes the skin significantly soft and shiny.
- It prevents wrinkles and aging
Early signs of aging just like the discoloration, wrinkles and decreased elasticity of the skin is one of the most biggest cosmetic issue. Luckily, peanuts contains a huge number of Vitamin C that is important for the production of collagen.
Preparation and Serving Methods
- Peanut kernels are often consumed as is, by simply cracking them with firm pressure between fingers or using clippers or nutcracker machine.
- They are nutty but pleasurably sweet in taste. Roasting enhances its taste, augment antioxidants level such as p-coumaric acid and it also helps in removing toxic aflatoxin.
- Both roasted and crushed kernels are usually sprinkled over salads, desserts, particularly sundaes and other dairy-based preparations.
- Boiled peanuts contains a unique flavor and taste. Boiling, as a matter of fact, develops their nutritional and antioxidants profile.
- Peanuts butter is a finished product from roasted nuts, with or without the addition of oil.
- Peanut “chutney” or paste is made up from these nuts, chili peppers, salt, coriander, leaves, garlic and also mustard seeds.
- Peanut oil is another healthy source of appetizing cooking oil such as soy or olive oils.
Peanut allergy is a type of hypersensitivity response in some people to certain food substances prepared using these nuts. As a result, the person may experience vomiting, stomach pain, sweliing of lips and throat leading to breathing difficulties, chest congestion and the worst is death.


The big freeze is set to continue today following the coldest night recorded in Huddersfield since 2013.
Huddersfield weatherman Paul Stevens tweeted this morning that the mercury reached an arctic -4.9c last night.
While in neighbouring Calderdale the authority's Highways team tweeted: "The minimum recorded road surface temperature at our Pecket Well (Hebden Bridge) weather station overnight was -7.5c with means some roads in the borough would be approaching -9c."
Salendine Nook meteorologist Paul Stevens added: "This evening frost and ice will develop quickly as temps fall initially to -3c.
"Later in the night as cloud increases from the North West temperatures will lift towards 0c at dawn on Thurday.
"Thursday may well start off very icy, especially if any light rain falls on frozen surfaces early in the morning, before less cold temps arrive from the west.
"Most of the day will be cold and wet, with rain at times.
"Rain will clear Thursday night to leave further icy roads then Friday will be windy, colder again with sunshine and wintry showers, some of the showers early in the day heavy leading to temporary accumulations to higher ground.
"The further outlook is to remain unsettled with spells of rain from the Atlantic with sunshine and wintry showers to follow."
The Weather Channel says the sun will stay out until lunchtime today, becoming cloudy at about 1pm.
By 5pm temperatures will hit zero, but wind chill means it will feel like -4c.
The Met Office is predicting a cold but dry day across Yorkshire, with a widespread frost to start; some long spells of sunshine through the morning, becoming increasingly hazy from the west during the afternoon.
Meanwhile, Thursday is set to be slightly warmer with some rain, dropping again on Friday.
Here is your hourly forecast for the next 24 hours.
9am-noon: Sunny; -1c to 3c
1pm: Partly cloudy; 3c
2pm-8pm: Mostly cloudy; 3c to 0c
9pm-midnight: Partly cloudy; 0c
Thursday 1am-5am: Partly cloudy, 1c-2c
6am: Mostly cloudy; 2c
7am-8am: Cloudy; 2c-3c


Saturn's Moon Enceladus on Oct. 28, 2015
A view of the surface of Saturn's moon Enceladus, acquired by NASA's Cassini spacecraft during a close flyby of the icy moon on Oct. 28, 2015.
Enceladus’ Heavily Cratered North Pole
This image, captured on Oct. 14, 2015 by NASA's Cassini spacecraft, shows heavily cratered terrain around the north pole of Saturn's icy moon Enceladus.
Cassini Spacecraft Flying by Enceladus
An artist's illustration of NASA's Cassini spacecraft flying by Saturn's icy moon Enceladus. Cassini is making its final close flybys of Enceladus in 2015.
Enceladus Cross Section
A slight wobble in Saturn's moon Enceladus reveals that the world contains a global ocean beneath its icy crust. Some of this ocean spurts out into space from the southern polar region.
Enceladus Southern Terrain
The Cassini spacecraft's close view of the southern terrain of Saturn's moon Enceladus, which contains a massive global ocean under its surface, scientists recently confirmed.
Enceladus, Saturn's Snowball
Saturn's moon Enceladus, covered in snow and ice, resembles a perfectly packed snowball in this image from NASA's Cassini mission released on Dec. 23, 2013. This view was taken by Cassini on March 10, 2012. It shows the leading side of Enceladus. North on Enceladus is up and rotated 6 degrees to the left. [Read the Full Story Here]
Frozen in Time: Saturn's Enceladus
NASA's Cassini spacecraft captures a still and partially sunlit Enceladus, the icy moon of Saturn, in this image released on Dec. 23, 2013. This image, taken on April 7, 2013, shows the side of Enceladus (313 miles or 504 kilometers across) that faces backward in the moon's orbit around Saturn. The view was acquired at a distance of approximately 123,000 miles (198,000 kilometers) from Enceladus. [Read the Full Story Here]
Enceladus Plume 1024
Light reflected off Saturn allows the Cassini spacecraft to capture both the back-lit plume and the surface of Enceladus in one shot as seen in this amazing space wallpaper.
Raw, Unprocessed Image of Enceladus
This raw, unprocessed image was taken by NASA's Cassini spacecraft on May 2, 2012. The camera was pointing toward Enceladus at approximately 239,799 miles (385,919 kilometers) away.
This raw, unprocessed image was taken by NASA's Cassini spacecraft on May 1, 2012. The camera was pointing toward Enceladus at approximately 260,443 miles (419,142 kilometers) away.


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The Red Wings fell to the St. Louis Blues 4-3 in overtime Wednesday night at Joe Louis Arena. Can’t see the gallery? Click here to view them on our Flickr account. All photos by Michael Caples/MiHockey.
- Ryan Hartman talks about his whirlwind season
- NAHL Top Prospects Tournament coming to Troy

domain: news


Editor in chief of PopCrush. Follow Bradley at @MuuMuse.
22 People Dead After Bombing at Ariana Grande Concert in Manchester
At least 22 people are dead after a terrorist attack at Ariana Grande's concert in Manchester on May 22.
George Michael Dead at 53
The legendary UK singer, who started his career in the band Wham, died today (Dec. 25).
Britney Spears Joins James Corden on ‘Carpool Karaoke’
Are you ready for some Karaokeney?
Bobbi Kristina Brown, Daughter of Whitney Houston and Bobby Brown, Dead At Age 22
Bobbi Kristina Brown, daughter of the late Whitney Houston and Bobby Brown, has died at age 22.


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Amazon Prime Day is an annual summer shopping holiday that’s exclusive to Amazon Prime subscribers, giving shoppers an opportunity to snag some incredible deals and major price cuts well ahead of the madness of holiday shopping.
This year, Prime Day launches on June 21st with some deals lasting up to 36 hours. Don’t worry if you don’t have Amazon Prime, you can sign up for a free trial just to take advantage of the deals!
While Prime Day deals reach across all categories on the online superstore (like this Amazon Fire Stick for only $17.99!), we’ve scoured the pet category to bring you the Best Prime Day Deals for Cats!
From beds to bowls and carriers to cat condos, Amazon Basics Pet Essentials are the everyday items pet parents need to give the very best to their furriest friends.
Up to 30% Off for Prime Day! SHOP PET ESSENTIALS
Advantage II is a veterinarian-recommended, monthly application that kills fleas through contact, so they don’t have to bite your cat to die. This cat flea treatment comes in a convenient topical liquid that is easy to apply and fragrance-free. A single application of Advantage II flea prevention starts working in 12 hours and keeps killing fleas for up to 30 days. Even indoor cats need flea protection because humans and other pets can bring fleas into your home. Fight the misery of biting fleas with the help of Advantage II 6-dose small cat flea prevention. SHOP FOR ADVANTAGE II HERE
Mealtime is more than just a bowl of food. It’s the foundation to a longer and healthier life, together. That’s why Wellness crafts delicious recipes that use simple, natural ingredients—without any fluff or fillers.
Now’s your chance to stock up! Amazing deals on Wellness CORE and Wellness Complete Health dry food, as well as many varieties of Wellness cans and pouches of wet food. Don’t miss 30% off Kittles cat treats, too!
Wellness cat food covers a wide range of needs for your unique cat. SHOP WELLNESS HERE
This comfy round cuddler bed has deep walls to provide the perfect getaway for your pet to relax in comfort and style.
Features high-loft, pet-safe fiber filling to promote comfort and a cuddly, nest-like design that encourages cats to curl up for a peaceful sleep. SHOP CUDDLER BEDS HERE
If you are a busy pet parent, Petcube Bites 2 Lite is your ultimate pet camera that allows you to spy on your furkids whenever you are away and wherever you are. Its advanced treat tossing mechanism with a 1.5 lbs container lets you fling treats short, medium, or long distance to reward your pet for good behavior, ease separation anxiety, or enhance their training.
If spying and treating your pet is not enough, you can always speak with them via high-quality 2-way audio and hear them bark or meow back! Never miss a moment with lifetime sound and motion alerts, HD 1080p live streaming video, 160° wide-angle view, crisp 30-feet night vision, 8x digital zoom. Take your pet to vet online with Vet Chat: on-demand vet support available 24/7/365 to answer health, nutrition, or behavior-related questions, and advise you if a case is an emergency. SHOP PETCUBE HERE
At BISSELL, they know pets can make messes – that’s why they created the Pet Hair Eraser Turbo Rewind upright vacuum. It doesn’t matter if you vacuumed just hours earlier, Fluffy will leave hair wherever, whenever, so you need to be ready for messes at any moment.
The Pet Hair Eraser Turbo Rewind provides powerful pickup packed into a convenient and agile machine for easy, everyday cleanup. Enjoy the Quick Release Extension Wand, which is always on and always ready to tackle those tricky, hard-to-reach pet messes around the home. You can also breathe easy with the Smart Seal Allergen System that traps dirt and allergens. It also comes with an optional Febreze filter that eliminates odors while you clean, letting you enjoy a fresher home. Plus, with features like the Tangle-Free Brush Roll and a One-Touch Easy Empty Dirt Tank, you don’t have to worry about cleaning your vacuum after you’ve cleaned your home. And getting your vacuum ready for storage is as easy as pushing a button with the Automatic Cord Rewind feature.
BISSELL proudly supports BISSELL Pet Foundation and its mission to help save homeless pets. When you buy a BISSELL product, you help save pets, too. SHOP BISSELL HERE
FRONTLINE Plus for Cats has been trusted by veterinarians for flea and tick control for cats for nearly 20 years. Made with 2 tough killing ingredients – one to kill adult fleas and ticks and the second to kill flea eggs and larvae – this fast-acting, long-lasting protection provides flea and tick control for cats and kittens 8 weeks and older.
Its long-lasting formula is stored in the oil glands of the pet’s skin to give non-stop flea and tick protection for a full 30 days. Make sure to select the appropriate size for your pet. SHOP FRONTLINE PLUS HERE
Remember to check Amazon Prime Day deals regularly as many items are limited and new items are added! Happy Shopping!

domain: pet


text:
NEW YORK--(BUSINESS WIRE)--Kroll Bond Rating Agency (KBRA) assigns preliminary ratings to three classes of mortgage pass-through certificates from Sequoia Mortgage Trust 2013-2, a jumbo prime RMBS transaction.
The mortgage pool backing SEMT 2013-2 is comprised of 777 first-lien mortgage loans with an aggregate principal balance of $666,125,405 as of the cut-off date. The loans in the pool are all fixed-rate mortgages, primarily with 30-year maturities. The pool is characterized by substantial borrower equity in each mortgaged property, as evidenced by the average LTV (63.1%) and CLTV (65.3%). The weighted average credit score of the mortgage pool is 773, slightly higher than average for 2012 SEMT transactions and well within the prime mortgage range.
KBRA’s analysis of the transaction included a loan-level analysis of the mortgage pools using our Residential Mortgage Default and Loss Model, together with a review of the transaction parties, results of loan file reviews performed by independent third party firms and review of the legal structure and key documentation. This analysis is further described in our U.S. RMBS Rating Methodology.
For complete details on the analysis, please see our Pre-Sale Report, Sequoia Mortgage Trust 2013-2, which was published on January 22nd 2013 at www.krollbondratings.com.
Expected Initial Class
U.S. RMBS Rating Methodology, published January 9, 2012
Residential Mortgage Default and Loss Model, published January 9, 2012
About Kroll Bond Rating Agency
KBRA was established in 2010 by Jules Kroll to restore trust in credit ratings by creating new standards for assessing risk and by offering accurate, clear and transparent ratings. KBRA is registered with the U.S. Securities and Exchange Commission as a Nationally Recognized Statistical Rating Organization (NRSRO). In addition, KBRA is recognized by the National Association of Insurance Commissioners (NAIC) as a Credit Rating Provider (CRP).

domain: finance


text:
Steroid related weight gain
Steroids taken for a long time can also cause your muscles to become weaker, and they might occasionally affect periods in women. Steroids are taken in different ways, and the dosage may vary depending on the condition you have. The table below gives an idea of how often you might need to take steroids. Please read this information sheet from GOSH alongside the patient information leaflet (PIL) provided by the manufacturer.
- Non-steroidal anti-inflammatory drugs (NSAIDs) are a group of commonly used painkillers.
- Exercise does help, even if it is only 10 minutes of walking – some days that may be all you will feel like.
- So it is possible to trick ourselves into consuming less energy, without feeling hungrier, by eating foods with a low energy density (low calorie content per gram of food).
They shouldn’t be used if you have an ongoing widespread infection. However, you should continue to take corticosteroids if you develop an infection whilst taking them. Always tell other doctors, nurses, pharmacists or dentists that you’re having this treatment. For example, if you need treatment for anything else, including teeth problems.
Side effects of cancer drugs
Steroids might affect some medical conditions, such as diabetes, heart or blood pressure problems, or mental health issues. If you have any of these conditions, the person treating you will need to make sure the steroids aren’t making the condition worse. Some of the more common side effects of long-term steroid administration are listed in Table 2.
- A study by the World Cancer Research Fund (WCRF) found that burgers, for example, have doubled in size since 1980.
- There’s no evidence to suggest that using a steroid inhaler during pregnancy increases the risk of problems like birth defects.
- TA also responds well to steroids but the starting dose is much higher (60mg) than for PMR.
- You may gain weight, or your face, ankles and legs may swell.
Regular cardiovascular activity will increase levels of serotonin, improving your mood. Improved mood and reduced stress will help you make wiser food choices. By the end of this period, there were no differences in weight between patients and liver function ceased to be significantly different from baseline.
Stopping your medication
Eat slowly and you’ll have a better chance of avoiding that over-stuffed feeling. At home, serve yourself a smaller portion and think about whether you really want a second helping. Not surprisingly, research shows that when we’re given a larger portion, we tend to eat more.
To prevent stress from sabotaging your efforts to lose or maintain weight, find ways to cope with stressful situations that don’t involve food, e.g. Non-steroidal anti-inflammatory drugs (NSAIDs) are a group of commonly used painkillers. Anticonvulsants are medicines used to prevent seizures (fits).
The chronic, unpredictable nature of MS makes it difficult to manage. It is understandable that you won’t always have a willingness to take part in physical activity but consider exercise as part of an overall management plan. For a full list, see the leaflet inside your medicine packet.
Irritation to stomach lining
You are more likely to have a serious side effect if you take a higher dose of prednisolone or if you have been taking it for more than a few weeks. If symptoms carry on, ask your doctor if you may benefit from taking an additional medicine to protect your stomach. Some side effects, such as stomach upset or mood changes, can happen straight away.
With your appropriate medication and relevant nutrition you will be optimising your management of the situation. It’s always best, of course, not to develop the stitch in the first place. Improving your fitness level – in particular, strengthening the core muscles – will help.
Nine medical reasons for putting on weight
You might also be given a drug called a proton pump inhibitor or another medicine to protect your stomach. This page is about steroids that can be taken as tablets, liquids, creams and eye drops and ointments. Information about buy anabolic steroids steroid injections is covered on a different page. Older medicines may have been used effectively for many years in children without problems but the manufacturer has not been required to collect data and amend the licence.
Skin thinning is an uncommon, temporary side-effect of steroids, but when combined with weight gain, it can result in stretchmarks. With long-term use of steroids, your legs and shoulder muscles may feel weaker. If you have to use steroids for a long time, it can lead to increased pressure in the eyes (known as ocular hypertension). This high pressure can damage parts of the eye that are vital for vision, such as the optic nerve.
Medicines that can interact with corticosteroids
Please take time to read the patient information leaflet that comes with your medicine. However, they’re not usually recommended unless the potential benefits outweigh the risks. Corticosteroids are mainly used to reduce inflammation and suppress the immune system.


text:
Let it Bleed
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Let it Bleed is the twenty first episode and penultimate episode of the sixth season.
Written by: Sera Gamble
Directed by: John Showalter
Original Air Date: 05/20/11
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domain: entertainment


text: We are back in Miami after a great trip to the Big Apple, New York City. One of the great things about the city is that it seems like you can find anything you could imagine to eat. Including great healthy places to eat. It seemed to us that every couple of blocks there was another great place to eat! On top of that beautiful outdoor markets and organic farmers line some of the squares in the heart of the city. Hopefully more cities take note and we can all dive in!! If your visiting NYC anytime soon here is a list of places to check out!


Finally got the boat at WOT this weekend. Fully loaded 24 seasport, full gas, gear and 3 guys. Flat water and the twin 150 yamaha's will do 45 mph and max RPM is 5200 on the starboard and 5000 on the port engines. The props are 13 3/4 X 19.
I understand a lower pitch prop will give me more RPM's, however that isn't a problem for me as I enjoy a 4000 rpm cruise ~ 30mph and 14 gph.
Question is, will a lower pitch give me any better fuel economy?


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Carlos Gonzalez will remain in left field, creating competition in center
Carlos Gonzalez will remain the center of attention for the Rockies, but not in center field. After talking with Gonzalez on Saturday, manager Walt Weiss said he will keep Gonzalez in left, where he has played the last two seasons, leaving Drew Stubbs, Charlie Blackmon, Corey Dickerson and Brandon Barnes vying for the center-field job.
It’s possible it will be a platoon given Stubbs’ numbers against left-handers and the fact that Blackmon and Dickerson both have enjoyed success against righties. Gonzalez said he was open to moving to center field following the Dexter Fowler trade. However when the Rockies acquired Stubbs, a true center fielder, CarGo’s move became less necessary.
“We are feeling comfortable with the alternatives, watching these guys run around. The big thing is we want to keep CarGo on the field. Risk and reward has kind of swung the other way,” Weiss said. “We are in a different place than we were in the fall. That’s what it comes down to.”
Weiss finalized the move after speaking with Gonzalez the past two days. Gonzalez was agreeable to playing center, but recognized the potential toll it could take on his legs. The position has worn down every Rockies starter over the last decade from Preston Wilson and Juan Pierre to Jeromy Burnitz and Fowler.
“The alternatives and the other options are good options,” continued Weiss. “We feel like it is our best shot to keeping Cargo healthy and not putting too much on his plate.
Gonzalez, who has won three Rawlings Gold Gloves over the past four seasons, has played left field exclusively since 2011. He said this week that he earned the right to “have the stability of one position” after bouncing from spot to spot earlier in his career. He hinted that his preference was to stay in left, and his one demand was that they keep in him in a single position, explaining that moving around left him more vulnerable to injury.
CarGo was not immediately available for comment, but explained his view of the situation on Monday.
“The other guys are going to make the difference on whether I play left or not. We have guys who can play center. Stubbs is a true center fielder,” Gonzalez said. “So if he’s out there with the other guys then they keep me in left. I am OK with that.”

domain: sports


text:
Evil In The Supermarket
Evil In The Supermarket
A S D movement
- Mouse attack
- Shift run
- Esc pause
To get a diploma from this high-school, you'll need to meet experts from hell. You need to pass multiple tests and then a grand-final test. The game contains multiple levels, has great graphics and interesting gameplay. You can't let good win over evil, because that would mean game-over for you. There's always good in each level and demons are often outnumbered.
65% 7.9k plays
Published: Sep 6th, 2017 HTML5 If you love fighting endless hordes of enemies, you found the right game.
73% 20.7k plays
Published: Apr 29th, 2016 HTML5 Fight on the battlefield against enemies from around the world.
83% 67.2k plays
Published: Jul 30th, 2020 HTML5 Play this multiplayer game and fight against enemies in WW2.
84% 80.7k plays
Published: Jun 2nd, 2020 HTML5 An action game where you will be fighting in tanks, helicopters or other vehicles.
85% 21.3k plays
Published: Feb 4th, 2020 HTML5 Next installment of the game where you’ll be playing as Trevor and wreaking havoc in the city.
83% 250.8k plays
Published: Jan 29th, 2020 HTML5 Try to make yourself look like a prop or play as a hunter and look for enemies.
79% 20.8k plays
Published: Jan 2nd, 2020 HTML5 Play GTA in the future and complete many different missions.
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Published: Sep 2nd, 2019 HTML5 The second installment into a great game where you will have to escape from a prison.
82% 38.9k plays
Published: Aug 16th, 2019 HTML5 The sixth installment into the Soldiers series, where you will yet again be fighting in a war.
85% 36.1k plays
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Published: Feb 27th, 2019 HTML5 Try out yet another game in the theme of GTA and start the chaos.
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Published: Dec 1st, 2022 HTML5 A great 3D survival game where you start on an unknown island and your goal will be to get different raw materials.
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Published: Nov 26th, 2022 HTML5 The great Sonic is back and you will have to collect rings and defeat all the enemies on the island.
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Published: Aug 20th, 2015 HTML5 Spend another 5 nights in the fourth game of this horror online game.
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Published: Jun 14th, 2015 HTML5 This is a sequel of a cool horror online game.

domain: game


text:
If you live outside of the European Union you don’t have to pay VAT.For our European customers we need to collect EU-VAT at the rate of the home country of the customer.
If you are a business located within the European Union (not Belgium), and you have a valid VAT-number, you can enter that number at checkout to be exempted from VAT.
North America Continents
Antiqua and Barbuda • The Bahamas • Barbados • Belize • Canada • Costa Rica • Dominica • Dominican Republic • El Salvador • Guatemala • Haiti • Honduras • Grenada • Nicaragua • Mexico • Jamaica • Panama • Saint Vincent and the Grenadines • Saint Kitts and Nevis • Saint Lucia • United States of America
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Argentina • Bolivia • Brazil • Chile • Colombia • Ecuador • Guyana • Paraguay • Peru • Suriname • Uruguay • Venezuela
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text:
A stroke is a medical condition which is characterized by rapid loss of brain function which is caused by interruption in the blood supply to the various parts of the brain. It can be due to a blockage and it’s known as thrombosis or lack of blood flow known as ischemia or a leakage of blood that is hemorrhage (Feigin, 2005). It results in the person’s inability to move certain parts of the body.
The brain is designed in such a way that the right hemisphere always controls the left side of the body while the left hemisphere controls the right side of the body. This explains why Joseph’s left part of the body got paralyzed even if not entirely. This also depends on the part of the right side of the brain that has restricted blood flow.
Joseph’s left face and hand has been paralyzed, but not the rest of his arm or his leg because of therestricted blood flow to a portion of his right precentralgyrus which is known to control moments of the muscles in the left face and hand and it is the right side that controls the left side.
What is preventing Joseph from moving his left hand is because of lack of communication between neurons that is between the central nervous system and motor neurons.
Motor neurons are neurons that transmit signals from the brain to the effector cells which include muscle cells. Motor neurons form synapses with effector cells. When an action potential reaches a synapse pore which are present in the cell membraneopens which in turn allows positively charged calcium ions into the pre synaptic terminal. This causes neural transmitters which are chemical in nature to be released in a gap between the two cells and this is known as the synaptic cleft. The neural transmitter is able to diffuse across the synaptic cleft and proceeds to interact with proteins called receptors which are usually embedded in the post synaptic membrane(Sherwood, 2001). The receptors serve as ion channels which allow charged atoms to pass through pores within their structure and this ispropagated along the dendrite towards the soma.
The destruction of a neuron that communicates with the motor neuron prevents Joseph from moving his handby disruption of the transmission process. The motor neuron is not able to receive signal from the central nervous system neuron and thus it is not able to propagate the signal to the effector muscle that is the hand (Garrett, 2011).
In an adult human being the brain takes longer time to redevelop damaged neurons because the neurons are fully developed and this is because why Joseph’s brain cannot simply replace the damaged neurons immediately(Altman, 1963). Compensation might allow Joseph to regain some of the lost movements. This occurs through the neurons that were not damaged and serve extra role of transmitting signals for the damaged neurons but this takes time and it is achievable through therapy. Experimental treatment that might improve Joseph’s movementof his left hand is by slowly exercising the hand through aided extension and constriction of the hand muscles. The exercises can bedone from time to time and it impacts on his nervous system by using the existing motor neurons to transmit signals to the hand. His nervous system will slowly undergo rearrangement so that it can utilize the existing neurons to control the left hand.
It is possible for the nervous system to recover from damagethrough natural processes for example compensation and reorganization. These processes enable the recovery of impaired functions for example of limbs and hands or any other impaired part. There are also experimental treatments that facilitate the growth of new neurons in a mature nervous system.Through proper treatment and therapy patients who suffer stroke do not suffer permanent disability especially because of these processes.This has greatly aided patients who have suffered strokes to be able to regain function of the affected parts through therapy.
Altman, J. (1963). Autoradiographic investigation of cell proliferation in the brains of rats and cats.Chicago: The Anatomical record.
FeiginVL. (2005). Stroke epidemiology in the developing world. USA:Lancet.
Garrett, B. (2011). Brain and Behavior: An Introduction to Biological Psychology (3rd ed.). Los Angeles: Sage.
Sherwood, L. (2001). Human Physiology: From Cells to Systems (4th ed.). Pacific Grove, CA: Brooks-Cole.
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text:
Family caregiving experience and health status among Chinese in the United States
AdvisorPhillips, Linda R.
MetadataShow full item record
PublisherThe University of Arizona.
RightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
AbstractIt is estimated that by 2025 the Asian population in the United States will be over 40 million; it will represent nearly 10% of the total U.S. population. Currently Chinese immigrants are the largest Asian group and constitute 22.6% of all Asian immigrants. With the Chinese immigrant population growing steadily, the Chinese elderly population will increase in the future. Historically, "Hsiao" (filial piety in English), rooted in Confucianism, teaches Chinese people to pay respect to living parents and provides rules for culturally defined intergenerational relationships and family caregiving, and putting family needs above individual interests. Among the Chinese, family caregiving is perceived as a duty, obligation, responsibility, and cultural virtue. The purpose of the study was to test a theoretical model specifying how factors including subjective beliefs of traditional filial obligation, subjective feelings about role requirements, perceived burdens, perceived rewards and use of coping affect Chinese caregivers' health in the United States. The aim of this study was to understand how caregivers' cultural background and the appraisal of family caregiving affect caregivers' well-being. Data from 137 caregivers were used to describe sample profile and for model testing. The original model failed to explain the data adequately. Two revised models were developed. Results suggest that data fit better with physical health, as indicated by CFI = .91 and the χ²/df ratio = 2.9, than mental health model, as indicated by CFI = .90 and the χ²/df ratio = 3.5. Findings suggest caregivers' beliefs of traditional filial obligation is a primary predictor for caregivers' physical health. Caregivers' subjective beliefs of traditional filial obligation affect caregivers' physical health not only directly but also indirectly. Implications for nursing research, practice, education and theory construction, and policy making were addressed. Limitations and recommendations for research design and interpretation of model fit were described. Further studies are needed to compare differences in cultural influences among different ethnic groups, identify effective coping style and test the effect of intervention caregivers' health.
Degree ProgramGraduate College


Linus shows humility in apology to Linux kernel developers
Linux creator Linus Torvalds isn’t known for mincing his words, but in his latest update, he’s apologised for his rude behaviour towards kernel developers.
The apology was made in the latest email to kernel developers regarding the most recent Linux 4.19-rc4 release.
Only a quick note was made regarding the actual kernel, mentioning small changes and being ‘fairly average in size for this stage in the release cycle’. However, the ‘other, much longer, part’ (in Linus’...


text:
There’s about a week until the impending free agents are allowed to talk to the other teams. Clubs have an exclusive negotiation window with their free agents for five days after the end of the World Championship.
An extension of any notable off-season free agent close would score as a huge surprise, but teams will still be in touch with their best players. Brave and all star short Dansby Swanson We’ve been talking about potential contracts since at least mid-August. Justin Toscano of the Atlanta Journal-Constitution wrote last month that the two sides exchanged formal proposals, and John Heyman of the New York Post now sheds more light on the discussions. According to Heyman, Braves bid in the $100 million range at some point during the season.
Exactly when the Braves made the proposal is unknown, but it is now clear that Swanson is in a solid position to cash in nearly $100 million in his next deal. He headed to a free agency following a career year. The previous first overall pick had always been a solid defensive stopping point, but he was arguably the best defensive player in the game in 2022. That earned him his first Gold Glove career a few months after his first trip to the Midsummer Classic. Swanson also had one of his best offensive tackles, connecting in 25 home rounds and spreading a .277/.329/.447 streak while playing every one of Atlanta’s games.
Swanson’s production waned a bit in the second half, but his overall streak was 16 points above the league average on the WRC+ scale. This is true in line with the platform public view of Javier Baez And even better Trevor’s storyEvery single one of them was a free agent in a loaded shortstop class off last season. Both Báez and Story have been going seasons as young as 29, as is now the case with Swanson. They each took out $140 million in guarantees on the open market, and both players locked opt-out terms into their deals (although the Red Sox can bypass Story opt-outs by activating the club’s option for season seven). Swanson’s representatives at Excel Sports Management are certainly well aware of those recent precedents, and it makes sense that they might be looking to beat the $140 million mark.
Both Swanson and Atlanta, head of baseball operations, Alex Anthopoulos, registered their joint desire to keep the stage short in Atlanta. Swanson is a Georgia native who has never played for another team in the big league, and it stands to reason that he would be happy to stay. It’s not known if he’ll get some sort of discount for doing so, though he apparently declined an offer in a nine-figure world that suggests he’s not entirely averse to market testing.
Braves have been removed for a year from a major predicament with the former franchise icon Freddy Freeman. Those talks reportedly got in the way of the Braves’ reluctance to go on for a guaranteed six years, and Freeman eventually signed with the Dodgers after Atlanta switched relegation and extension. Matt Olson. Freeman was also a client of Excel Sports Management at the time, but Swanson has consistently maintained that stepping back from the job would have no effect on his relationship with the Braves or his agency.
Obviously, Swanson’s refusal to offer an extension is no guarantee of his departure. Heymann reported that the proposal was made at some point during the season, and Anthopoulos confirmed after their season ended, that the team was still interested in a long-term deal. It makes sense that they have kept in touch and will continue to do so throughout the season. The Braves are sure to make a qualifying bid for Swanson next week, which he will turn down in search of a much longer and higher commitment.
#Latest #Extension #Talks #Braves #Dansby #Swanson


The new single Feel It from the (shockingly) Oscar award-winning rap group Three Six Mafia is an all-star collaboration of talent. The track is co-produced by DJ Tiesto, arguably the world’s best DJ, and newcomer DJ Frank E (see Chamillionaire’s Good Morning) and features chart topping artists Flo Rida and Sean Kingston. The beat starts off hard and fast, and the techno sound never lets up, allowing all three artists to sound energetic and comfortable on top of the fist-pumping production work. Both beatsmiths make the bass bang loud at all the right times, knowing when to sit back and just let the beat detonate. The song also has a catchy chorus line from Kingston, which helps keep the track balanced against Three Six and Flo Rida’s dirty rhymes. The best part of Feel It? When the beat builds up slowly and then explodes in the last minute. It’s not exactly what fans of the Memphis veterans have come to expect, but new-found success sometimes breeds change. Feel It is off Three Six’ upcoming album Laws of Power, due out in January of 2010.
Written by matt juss on 11/9/09
First DJ Booth Appearance:
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