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Viola Davis’ career has become the stuff of legends. She’s the first African American triple crown actor, having brought together the holy trinity of awards in two Tonys, an Oscar, and a Primetime Emmy Award. She’s often the highlight in whatever film she graces, whether the star or not, and she has an uncanny instinct to choose the kind of challenging roles that accommodate her presence. Thanks to hard work, dedication, and an overwhelming desire to leave a mark on the world, Davis has forged a career for herself that’s significant and purposeful in its impact.
But there was a time in Davis’ historic Hollywood run where her success left her feeling a little unfulfilled, which later led to a crisis The Help star had trouble coming to terms with.
Viola Davis felt an emptiness after her role in ‘Doubt‘
Before her career took off, Davis put in years honing her craft on Broadway before transitioning over to film and television. Although the beginning of her career saw Davis taking small roles, she made those bit parts feel larger than life.
It’s that same prowess that landed Davis the role she’d spent her whole life gunning for in Doubt, starring alongside Meryl Streep and Amy Adams. Despite Davis only being in the movie for eight minutes, the world watched this familiar-yet-unpopular actor yank the scene away from two greats. This resulted in Davis being offered several high-profile roles as if it was Hollywood’s way of apologizing for taking so long to acknowledge her.
But to Davis, Hollywood success wasn’t synonymous with happiness. In a resurfaced interview with Oprah on Own, Davis describes how her Oscar-nominated role left her feeling empty inside.
“I went through a horrible midlife crisis, y’know, during Doubt,” Davis confided to Oprah. “Because I was nominated, and I worked with Meryl Streep, and I thought I should be happier than this. Yeah, I felt an emptiness. I didn’t know success felt that way.”
Viola Davis had to define her happiness
Viola Davis had to dig inward to find what she was looking for, but even searching for her own brand of happiness had an element of fear to it.
“I didn’t know that when you come to the midpoint in your life anyway, that there’s a certain amount of disillusion that comes with that,” Davis explained. “Then you’re there, you’re right at the middle part of your life, so then you have to think, ‘Ok, Viola, really, what would make you happy?’ And that’s really frightening, because the things that could make you happy may not look good to other people.”
Since her 2012 sit-down with Oprah, Davis witnessed her career reach even greater heights. She starred in ABC’s hit crime drama How To Get Away With Murder for six seasons. She’s dabbled in mega box office hits like Suicide Squad, and recently channeled the ghost of late Blues singer Ma Rainy in Ma Rainy’s Black Bottom.
With her commitment to Hollywood and her growing resume, it seems Davis has healthily moved past her midlife crisis. In regards to success, the actor has even commented on being in a more comfortable place during her older years.
“I feel more comfortable in my skin at 51, and I didn’t expect that to happen. I was bracing for impact at 50; at 51 I was bracing for the fall,” Davis told Today. “And the fall hasn’t happened. I’ve been blissfully comfortable in my own skin.”


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Exogenous Keto Diet Plan Reviews – Are you looking for weight-loss supplement? Ketone bodies are acidic, yet acid-base homeostasis in the blood is generally maintained with bicarbonate buffering, breathing payment to differ the amount of CARBON DIOXIDE in the bloodstream, hydrogen ion absorption by tissue healthy proteins and bone, and kidney payment via raised excretion of dihydrogen phosphate and also ammonium ions.
The major ketone bodies made use of for energy are acetoacetate and β-hydroxybutyrate, 4 and the degrees of ketone bodies are controlled generally by insulin as well as glucagon 5 The majority of cells in the body can use both glucose as well as ketone bodies for fuel, as well as throughout ketosis, cost-free fats as well as sugar synthesis (gluconeogenesis) fuel the remainder.
The initial ketone body to be produced is acetoacetate, followed by chemical reduction by beta-hydroxybutyrate dehydrogenase to beta-hydroxybutyrate with NADH as well as a proton as a cofactor, or loss of a carbon dioxide particle to create acetone As the liver itself lacks the metabolic equipment needed to utilize them, the product ketone bodies are completely released right into the blood for usage by the rest of the body.
Nevertheless, extra researches are needed before ketone supplements can be advised for appetite control. Think about zeal exogenous ketones reviews ketones sort of like alcohol. The function of the ketogenic diet for weight management is to generate ketones from stored fat as an alternate gas resource. This is referred to as endogenous ketosis– suggesting ketones are being generated by the body.
Ketosis is a metabolic state in which several of the body’s energy supply comes from ketone bodies in the blood, in contrast to a state of glycolysis in which blood glucose offers energy. The hypoglycemic activity of ketones. Ketones may be depressing dieters’ appetite as well as providing a hit of energy and also cognitive improvement, but it’s PREVENTING their capability to melt fat, offering zero nutrients, and doing nothing for their metabolic wellness.

domain: chemistry


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YieldMakes a large bowl. Can easily be halved. Keeps well for a few days.
1 head cauliflower, grated in a food procesor
4 green onions, diced
2 tomatoes, diced
1 orange bell pepper, diced
1 jalapeno pepper, diced
2 tablespoon fresh lemon juice
¼ cup cilantro, diced
1 avocado, mashed
1 teaspoon chili powder
1 teaspoon paprika
½ tablespoon sea salt
¼ cup cold pressed extra virgin olive oil
Mix together well and serve.
Ashira's ThoughtsBy Ashira
This recipe is taken from How We All Went Raw by Charles Nungesser and Stephen Malachi
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domain: food


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Guindo will be responsible for leading the development and implementation of the company’s long-term strategy for the Human Health portfolio.
Merck announced that Chirfi Guindo will lead Human Health Marketing as Chief Marketing Officer (CMO) for Merck Human Health, and will join Merck’s Executive Team, effective July 1, 2022. Guindo will report directly to Robert M. Davis, chief executive officer and president, Merck.
As previously announced, Jannie Oosthuizen leads Merck Human Health U.S., and Joe Romanelli will lead Merck Human Health International effective Aug. 1, both also reporting to Davis. Deepak Khanna, interim leader of Human Health International, will retire at the end of this year.
In his new role, Guindo will be responsible for leading the development and implementation of the company’s long-term strategy for the Human Health portfolio spanning oncology, vaccines, pharmaceutical and pipeline products.
Since 2017, Guindo has been executive vice president and head of global product strategy and commercialization at Biogen and served on Biogen’s executive leadership team. Before joining Biogen, Guindo began his Merck career in 1990 and spent more than 25 years in finance, sales, commercial and marketing roles of increasing responsibility in the U.S. and globally.
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domain: news


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Electralloy™: Industrial Thin Dense Chrome Plating
What is Electralloy™?
Electralloy™ is Electro-Coatings' exclusive thin dense chrome plating process, delivering a highly corrosion, wear, and friction resistant surface without significant dimensional distortion sometimes present in standard industrial thin dense chrome plating.
Chrome Plating Advantages
Electralloy™ is most useful when very tight dimensional tolerances are key and there are to be no secondary grinding or polishing operations. Additionally, the nature of the thin layer provides increased corrosion protection, due to the absence of micro-cracking found in industrial thin dense chrome, with thicker plating deposits.
An industrial chrome layer is deposed in a microscopically thin coating from 0.000025" to 0.0005" in depth, a density which will not materially change the micro inch value of the base metal. It can be applied to a wide variety of substrates and geometries. The chrome electroplating process produces an exceptional hardness and a high level of surface consistency, providing a coefficient of friction 40% lower than lubricated steel (.12 to .13 vs, steel at .20). The result is a marked reduction in abrasion, erosion, adhesive wear, scuffing or galling, scoring and seizing.
As an added bonus, thin dense chrome or industrial chrome plated parts are far more corrosion resistant than standard chrome plated parts. The surface inconsistencies that are a by-product of standard plating do not occur with the dense chromium composition and microscopic thickness of Electralloy™ coating. This attribute offers significant cost savings by allowing the substitution of low cost base metal for expensive corrosion resistant steels. Electralloy™ maintains its anti-corrosion protection across a wide temperature range, yielding consistent friction reduction without degradation by extreme heat or cold.
Thin Dense Chrome Plating Process & Specifictions
Generally, thin dense chrome plating includes several stages: stripping to degrease the metal and remove all traces of dirt, soil and other impurities; various pretreatments, including polishing and sanding; wiring and racking to hold parts in the plating tanks; and, finally, placement into a plating tank and application of plating current. There are variations to the process depending on the type of substrate.
- Fights friction without changing component dimensions
- Surface hardness to 70 Rockwell C
- Low coefficient of friction (0.12 to 0.13 against lubricated steel)
- Low heat application won't distort components
- Higher resistance to corrosion than standard chrome plating
- Performs in temperatures from -425° to +1150° F
Exceptional Application Skill
As with any thin dense chrome coating, successful Electralloy™ application relies on careful fixturing of parts and precise control of the plating bath. The plating craftsmen at Electro-Coatings have extensive experience at this critical process, and are solidly backed by the latest in costing technology and the engineering expertise of seasoned experts in the plating, coating and metallurgy fields.


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The RSPCA has appealed for a trio of unlucky cats struggling to find that perfect home.
One-year-old Minnie and her siblings Rory and Loki were returned to the center several months ago and have so far received little to no interest from potential adopters.
Their color and the rising cost of living are thought to deter people from adopting the three black cats.
Lara Di Virgilio, repatriation co-ordinator for the RSPCA’s East Berkshire branch, said: ‘It’s a sad fact that black cats really don’t have much luck; we see more of them coming through our door than any other cat color, and they consistently take longer to get home than their tabby or tortoiseshell counterparts.
READ MORE: Look inside: Rare Grade II listed townhouse on the market for £7.5million
“We urge people to look beyond what an animal looks like because the color of their fur makes no difference to the love they should give. Although we also think black cats are absolutely gorgeous!
“Black cats like Minnie, Rory and Loki won’t bring you good or bad luck, but they will certainly enrich your lives, and we urge anyone who is considering welcoming a rescue cat into their home, to give these three luck.”
Minnie, who was handed over to the RSPCA a month ago, is described as a particularly affectionate and friendly cat and enjoys socializing. Shortly after raising her kittens, she was placed in the care of the East Berkshire branch.
Brother and sister Rory and Loki, the five-year-old inseparable felines were placed in the care of the RSPCA in June after their owner could no longer afford to keep them.
They are a very shy couple but love to be cuddled and really come out of their shell once they have gained your trust and could be rehomed with elementary age children.

domain: pet


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Deming is a somewhat small city located in the state of New Mexico. With a population of 14,758 people and five constituent neighborhoods, Deming is the 12th largest community in New Mexico.
Deming is neither predominantly blue-collar nor white-collar, instead having a mixed workforce of both blue-collar and white-collar jobs. Overall, Deming is a city of service providers, professionals, and sales and office workers. There are especially a lot of people living in Deming who work in office and administrative support (9.04%), maintenance occupations (8.47%), and sales jobs (6.48%).
Residents of the city have the good fortune of having one of the shortest daily commutes compared to the rest of the country. On average, they spend only 17.64 minutes getting to work every day.
In terms of college education, the citizens of Deming rank slightly lower than the national average. 13.54% of adults 25 and older in Deming have a bachelor's degree or advanced degree, while 21.84% of adults have a 4-year degree or higher in the average American community.
The per capita income in Deming in 2018 was $17,090, which is lower middle income relative to New Mexico, and low income relative to the rest of the US. This equates to an annual income of $68,360 for a family of four.
Deming is an extremely ethnically-diverse city. The people who call Deming home describe themselves as belonging to a variety of racial and ethnic groups. People of Hispanic or Latino origin are the most prevalent group in Deming, accounting for 71.99% of the city’s residents (people of Hispanic or Latino origin can be of any race). The greatest number of Deming residents report their race to be White, followed by Black or African-American. Important ancestries of people in Deming include German, English, Irish, Italian, and Norwegian.
In addition, Deming has a lot of people living here who were born outside of the US (18.71%).
The most common language spoken in Deming is Spanish. Other important languages spoken here include English and Native American languages.

domain: sociology


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 Knapp to fans: Don't give up on Rousey vs. Cyborg

Without Joe Frazier, there would be no Muhammad Ali as we know him. Greatness in combat sports comes not from utter domination, but from winning the great fights.

UFC women's bantamweight champion Ronda Rousey is the best known female mixed martial arts fighter on Earth. She may even be the best know MMA fighter period. But she never had a great, defining fight.
The figure that woulda shoulda could give her that, and maybe more, is of course Invicta FC featherweight champion Cris 'Cyborg' Justino. For nearly two years the fight has edged closer and then receded back.
Now invicta FC president Shannon Knapp says it is closer than it has ever been.
"I can't really say that it will happen this year," said Knapp to Marc Raimondi for MMAFighting.com. "But what I can tell you is the fans should not give up, because this fight is closer than it has ever been -- ever. If it's gonna happen, I think we're gonna see it happen possibly by the end of this year or first quarter of next."
The pair will be fighting later this month less than a day and a mile apart. Justino, 29, defends her featherweight title against Charmaine Tweet in the main event of Invicta FC 11 on Feb. 27 in Los Angeles, live on UFC Fight Pass. Rousey defends her title against Cat Zingano at UFC 184, also in LA, live on PPV.
"I think it's going to be amazing," Knapp said. "And definitely I look at it as a landmark weekend for the women.
"Women have certainly carved out their spot in the sport and I think that's an amazing thing for the female athlete."
MMA promotion has only a few genuine heroes. But Shannon Knapp, whose #1 is goal is making a fight that won't even be in her organization, is on the very short list. And we all hope to see her dream fulfilled.


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In order to assess a large number of diverse projects as fairly and rapidly as possible, a procedure often adopted is to use a panel consisting of a large number of experts, only a small number of whom assess each project. Since no one expert assesses all the projects, conscious or unconscious bias regarding overall standards by any expert will advantage or disadvantage the projects assessed by that particular expert. This paper presents an iterative algorithm that has been used successfully to detect and correct for such biases. Each expert's assessments are modeled as differing from the ideal as a result of a shift of mean and having a standard deviation that is too low or too high. This model is used in conjunction with the concept of "paired assessments" to account for individual projects being of unusually high or low quality and so to evaluate the discrepancy from the ideal marks. The same computer program also has applications in the peer-review or expert-evaluation of research proposals, and any other situation involving subjective assessments by a restricted number of persons.

domain: literature


Superstar sky sports and La Liga pundit Guillem Balague has claimed that Manchester United thought that they could sign Sergio Ramos from Real Madrid during the summer transfer window and the deal was almost completed.
According to Balague, United entered negotiations with the Spanish club for the centre-back and the negotiations progressed with ease with the two parties expecting that Ramos would leave Madrid for England but the Spanish giants apparently had more up their sleeves than they showed United as the Spanish international ended up signing a new contract with Real Madrid.
Balague however admitted that he was not surprised by the outcome, but that Madrid played some trick to make members of the Old Trafford hierarchy confident that they could bring the 29-year-old defender to the club.
Balague said, “There were negotiations taking place. Manchester United thought they could have him. But I was convinced. Someone who dreamt of being the captain of Real Madrid, who was being the captain of Real Madrid, just wanted a bigger contract.”
United did not recover from this deception and ended up not strengthening at centre-back over the summer transfer window but ‘the god of football’ decided to smile on the Red Devils as Chris Smalling has been in tremendous form and has helped manager Louis Van Gaal to ease some of his defensive concerns that existed after the exit of Rio Ferdinand and Nemanja Vidic.
Balague is however of the opinion that Manchester United have not left Spain and that there is a genuine possibility of United signing another superstar with Neymar thought to be assessing his current situation at Barcelona.
Balague said, “Neymar is a completely different situation, believe me, and he is actually thinking ‘what shall I do next?’ because (Lionel) Messi will be there for four or five years if he doesn’t move and Neymar won’t be allowed to grow.”
It remains to be seen if Neymar will be ready to move especially with recent reports suggesting that Messi could move as soon as January which means Neymar could easily become the next best thing at the Nou Camp.


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Matt Barkley has decided to come back for his senior season at USC, and there were many reports that had him originally leaving for the NFL draft based on his spectacular junior season.
Throw in the fact that Barkley would have certainly been a top-10 pick in the 2012 NFL Draft, and some may be scratching their heads as to why he did indeed stay in school.
No so fast, my friend!
Barkley said it himself that this USC squad has "unfinished business," and they immediately become perennial national title contenders.
Depending on whether LaMichael James returns, the USC Trojans could—and in my book, should—be the team to eventually dethrone the bullies of college football.
Those bullies, of course, are the SEC champions that will have won six straight BCS titles. LSU will likely still be the No. 1 team in the country next preseason regardless if they defeat Alabama or not, but the Trojans should be right there next to those Bayou Bengals.
Although superstar left tackle Matt Kalil has left for the NFL draft, Barkley will have everybody else back on the line.
Oh yeah, he also has the best receiving corps returning, led by Robert Woods and Marqise Lee. Running back Curtis McNeal exploded out of the backfield in the final few games and has given USC a balanced offense.
Back to Barkley’s decision and speech, because he fooled some people even though it was a foregone conclusion as soon as we knew the band was going to be there. Barkley delivered a great speech and talked about the pros and cons and how it was and still is his dream to play at the next level.
The biggest thing that stood out was Barkley made it a point of how unfairly his Trojans were punished this season in not being able to play in the first Pac-12 Championship Game or a vital bowl game (the Trojans finished fifth in final AP poll of the regular season).
USC athletic director Pat Haden and his family sat with smiles as they were all glad to see another Trojan superstar return to the landscape of college football.
Coming off his 3,528-yard and 39 TD (7 INT) season, Barkley now has his eyes on a few more historic achievements.
He may very well be the easy choice as the frontrunner for the Heisman Trophy on top of playing in the BCS National Championship Game and being selected as the top pick in next year's draft.
More importantly, though, have you looked at USC’s schedule for 2012?
Nothing is cupcake city in college football, but they have several favorable and mouthwatering matchups.
They host Notre Dame (top-25) and Oregon (top-five), but their toughest road games look to be Stanford and Washington.
Throw in home games against Hawaii, Arizona State, Cal and Colorado, and you may start to feel as if it is a dream schedule.
The roadies are not a walk in the park in the new Pac-12, but Utah, UCLA and Arizona will just be fighting to stay relevant and in the bowl picture when they take on the highly ranked Trojans.
They will easily be favored in every single game as long as No. 7 is under center and healthy.
Certainly Cam Newton won the Heisman and BCS National Championship Game on top of being selected first overall, but Barkley might just be favored to do all three.
This offense may be unstoppable next season, and Lane Kiffin, offensive coordinator Kennedy Polamalu (formerly Polsa) and the rest of Trojans nation may have just received one of the greatest Christmas presents we have seen in years.


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I don't know quite where I going with the concept but I like the story thus far. If anybody has any ideas for me graphic wise or story wise please let me know... I am still very green when it comes to this, but I figured I'd give it a shot. Don't rake me over the coal to bad please! Pro football comes to Orlando! By Rich Garrett Orlando Tribune 4:24 p.m. EDT, March 13, 2014 ORLANDO — It's been announced that current Luchtvaart Aerospace Software © and Aero Barrage Magazine © founder, Michael Myers, has been awarded a pro football franchise. The former Northrop Grumman Vice President said Tuesday, "This has been a dream of mine for quite sometime! I grew up a vivid football fan, and now I think I've reached the ultimate moment in fandom." Myers stated that the team has already reached a deal with City of Orlando and Orlando Venues to have the team play at the newly renovated Florida Citrus Bowl Stadium. Myers stated that they still need to make some renovations to the adjacent Tinker Field. "We plan on demolishing the current Tinker Field press box and stands and build an all new team facility where we will house our coaching staff, and support staff offices, as well as, a state of the art training and weight room for the players. We will convert the current Tinker field playing surface into a practice field for the team" Said Myers, on Tuesday. As for logos and team colors, Myers stated that they would play homage to the "first pro football team in Orlando" the Orlando Breakers, of the hit 1989-1997 TV show "Coach." As for logos, Myers was undecided as of yet. "We're reaching out to various design firms to see what comes about, as of now." One thing is for sure football is back in "The City Beautiful"! E-mail Rich Garrett at email@example.com ---------- Break out the champagne! By Rich Garrett Orlando Tribune 2:21 p.m. EDT, April 10, 2014 ORLANDO — "Bring in" was more like "Break in" on Thursday afternoon at the Florida Citrus Bowl Stadium. As new team owner Micheal Myers announced that the new team would indeed be named the Orlando Breakers! Myers, reached out to Barry Kemp the creator and producer the hit ABC series "Coach" about using "Orlando's first football team" as the identity for well...Orlando's first football team. Myers, the current Luchtvaart Aerospace Software © CEO stated, "Mr. Kemp has been wonderful and generous throughout this whole process, and we appreciate his cooperation with us". Not long after that Myers contacted New Orleans real estate mogul Joseph Canizaro. Canizaro was taken aback by Myers call, but entertained him nonetheless. It was then that Myers informed him of the reasoning for contacting him. " I informed him that as young kid, the first football game I attended was a Boston Breakers game. By that time Mr. Canizaro immediately knew what I wanted to do". What Myers wanted to do was get the blessing to purchase the trademarks to the former USFL Breakers franchise. And Canizaro gave him just that. "I was thrilled he asked for my permission" Canizaro said on Thursday via phone. The Breakers will use the "Coach" TV Series colors as their primary and use the USFL team colors for throwbacks and other special occasions. You can visit the Citrus Bowl stadium on Friday at 8PM for the special public unveiling. There you can purchase items with both the new, and throwback Breakers logo. E-mail Rich Garrett at firstname.lastname@example.org ---------------------------------------------


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Today’s film is the 2012 short Fresh Guacamole. The film is written and directed by PES, and is nominated for an Academy Award in the category of Best Animated Short Film. PES is the stage name for Adam Pesapane, who has been making short films for a decade, often willing acclaim at film festivals such as Sundance. This film marks PES’ first Oscar nomination.
[vsw id=”FQMO6vjmkyI” source=”youtube” width=”640″ height=”425″ autoplay=”no”]

domain: artistic


HGI HRP28D 3.5 kva portable Petrol Generator Honda Engine
Designed for professional and intensive use, this high quality HGI HRP28D generator is capable of spending its lifetime supplying power to sites and demanding applications.
HGI 3.5kVA generator, 2.8kW rated power at 230 volts. Japanese quality Honda GX200 single cylinder air cooled engine and MeccAlte Alternator and a 3.6 ltr fuel tank. This set can provide a run time of 3.75 hours at 3/4 load.
- Rugged genuine Honda GX200 air cooled petrol engine for long term reliability
- Recoil engine starting
- Durable powder coated wrap around steel frame
- 1 x16a 110v socket
- 1 x16a 230v socket
- Lightweight and highly portable
The HGI HRP28D 3.5 kVA portable Petrol Generator comes with a 3 year WarrantyHampshire Generators can also maintain your generator with a regular cost-effective service plan or one-off visit. Simply call 01329 722390 or inquire via contact us page for more information.


Plümat FFS 992 SFC - Turkey
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"Nyce on the mic!"
Monday - Friday 10 am To 2 pm
In 2008 I attended the Institute of Audio Research and graduated with a 3.93 and a certificate in Audio Engineering & Music production. With my pure love for music radio was a natural choice. I love to be on the air and in the mix!
I've recorded and engineered songs for various local talent in the Delaware/Philadelphia area and have worked with a lot of different genres of music.
I was born in South Philadelphia and then I moved to Delaware when I was 9. The most important thing to me is my family and friends.
Birth Sign: Gemini
Where you grew up: Claymont Delaware


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Is there a simple way to change the input type in contour? I'd like to set it to type="tel" and type="email" to bring the "right keyboard" on mobile site.
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Guess you'll need custom fieldtypes for that, should be an easy update if you start from the shared sourcecode
Hit this problem with the first form we ever did with contour.. Although impressed with a lot of things, we're pretty disappointed with the customization possibilities.
Changing the rendered HTML properly seems to be borderline impossible. Don't know what to tell our web designer when he wants to change the h2 into a h3.
Hoping for improvements when the next release comes!
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GMC C15/C1500 Suburban / K15/K1500 Suburban 5.7L 1974, Direct Fit™ Pro Series Aluminum Radiator with Fan by DeWitts®. Inlet Location: Upper Passenger Side. Outlet Location: Lower Passenger Side. Fan Quantity: Dual. Fan Diameter: 11". Air Flow: 2780 cfm. Blade Color: Black. To replace your vehicle’s classic cooling system, install this Direct-Fit Aluminum Radiator from DeWitts. The radiator is covered by a manufacturer’s lifetime warranty to ensure that this will be the last radiator you need to purchase!
Fitment notes: Fits Models with Chevy small block Gen III/IV LS-based Engine.
|Radiator Style: Crossflow|
|Inlet Location: Upper passenger side|
|Outlet Location: Lower passenger side|
|Radiator Material: Aluminum|
|Row Quantity: 2|
|Fan Included: Yes|
|Fan Quantity: Dual|
|Fan Diameter: 11"|
|Maximum Fan CFM: 2,780 cfm|
|Blade Material: Plastic|
|Blade Color: Black|
|Shroud Material: Plastic|
|Radiator Cap Included: Yes|
- Durable construction to deliver dependable service for years
- Built using the most technologically advanced equipment
- High-end design ensures your greatest experience
All aluminum radiators begin with an aluminum "core," regardless of the brand or origin. The core is the most important part of any radiator because the quality of the radiator is dictated by the braze quality of the core section. The tubes must be bonded completely to the fin or heat transfer will suffer. All the tubes must be thoroughly brazed into the header plates or leaks will develop over time. This Direct-Fit Aluminum Radiator from DeWitts is the only aftermarket radiator that features brazed aluminum radiator cores built in house. It goes through the stringent quality control process to ensure superior quality and reliability.
DeWitts® aluminum radiators are Made in Michigan and we control 100% of the manufacturing process in house. DeWitts CAB brazing furnace allows us to produce the finest aluminum cores in the industry. They have the flexibility to build custom aluminum radiators in several tube widths and fin designs. DeWitts began building Direct Fit™ Corvette radiators over 15 years ago. DeWitts have expanded line to many other makes and models, using the same degree of attention.


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Dressed in hyacinth blue and heels, her blond locks crowned with baby's breath, 13-year-old Stephanie Frantz approached the altar of her Northbrook parish, added roses to a vase brimming with blossoms, then reverently lifted from a lacy cushion a wreath of pink carnations and placed it upon the Virgin Mary's porcelain head.
For the 8th graders at St. Norbert Parish School, the annual May Crowning is a rite of passage as well as a rite of spring. It also is a time to honor Mary, the mother of God--whom the Roman Catholic Church considers the queen of saints.
In the Catholic Church, May is traditionally the month of Mary. The timing is appropriate, said Rev. Don Woznicki, as May is a month of creation.
"We look to her as hope that someday we will be a new creation," said Woznicki, the parish's associate pastor. "She is the sign of someday how we will be."
Throughout the month, parishes stage May Crownings, ceremonies that include hymns and prayers to the Blessed Virgin, culminating with the crowning of a statue of the Queen of Heaven with a wreath of flowers.
Often performed after a mass, the ritual is not part of the church's official liturgy but a popular Marian devotion, like the rosary. But unlike the rosary, it is a formal ceremony instead of an individual act.
For some, the devotion has a personal resonance. Christina Zaker, 37, witnessed her first May Crowning last year, when her son took part with students at his parish school. The ceremony, she said, reminded her of her wedding day in May 1993.
On that day, she offered a short prayer to Mary, placed a rose beside her statue, then added a personal touch by handing a flower to each woman in her family, as a way of asking for their guidance. Little did she know at the time that the traditional and personal gestures would inspire a decade of devotion to the Mother of God.
"Putting that rose there, somehow I allowed Mary to be in my mind," said Zaker, a parishioner at St. Robert Bellarmine Parish in Chicago's Jefferson Park neighborhood.
"This crowning of Mary is of both the traditional, motherly, gentle woman figure, but also of a woman willing to take risks and to try to challenge for justice in our world," Zaker said. "That's someone to aspire to. It's a great way to understand that there's so much to Mary."
Experts say the origin of May Crownings can be tied to the Roman Empire, in which laurel wreaths symbolized royalty. In the Middle Ages, the honor was extended to saints, including Mary, whom the church had declared the mother of God by the 5th Century, said Rev. Gilbert Ostdiek, a Franciscan priest who teaches liturgy at the Catholic Theological Union.
The actual May Crowning ritual probably dates to the 16th Century, when St. Philip Neri, often credited with starting May observances, assembled youths for floral and musical tributes to Mary, said Rev. Thomas Thompson, director of the Marian Library at the University of Dayton in Ohio.
In the 19th Century, the crownings became a key part of the Catholic evangelization and missionary movement as well as a popular act of devotion in parishes, Thompson said. In the U.S., May altars became prominent centerpieces in Catholic homes and schools, and children looked forward to flowery processions and songs dedicated to the Blessed Virgin.
But after the Second Vatican Council of the 1960s, which aimed to restore the prominence of liturgy in the church, popular devotions fell out of favor. Some parishes abandoned the May Crowning tradition.
Now, experts say, devotions are regaining a foothold in the Catholic faith.
"It's a wholesome way of expressing that Mary is truly at the center of those who are in service of the Lord," Thompson said. "We all have much to learn from the example of Mary--her spirit of humility, her spirit of service--and that's why we exalt her."
At St. Norbert, as at many parishes, the crowning is not only a rite of passage--a tradition for 8th graders before they move on to high school--but a lesson.
At the ceremony this month, Woznicki conducted his homily as a question-and-answer session between him, the 8th graders and the 2nd-grade First Communion candidates, in their white dresses and suits.
"Jesus is king of kings," Woznicki said. "That's what makes Mary the greatest person God ever created and the greatest saint the church has ever had. She is the queen of all angels, prophets, everything."
At the conclusion of mass, pairs of teens dressed in blue robes marched toward the altar to place roses around the porcelain statue of Mary.
Chosen by her classmates to crown the queen because she best emulates the virtues of Mary, Stephanie stepped up to do the honors. The opportunity raised her consciousness, she said, and renewed her commitment to treat others with kindness and humility.
For Zaker, the spring ritual is a chance to renew the wedding promise she made 11 years ago. Her son participated in this year's May Crowning as a First Communion candidate, which made the event all the more moving.
"To be in touch with the fact that I want my son to also understand the role of Mary and the importance of a woman was powerful for me," Zaker said. "I do find that my mind-set of Mary and of God is every day. Being able to be at something like a May Crowning ... is an important way to solidify that there are a lot of people who feel the same way."


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( Downtown ) - Firefighters and police are all around Police District 1 Headquarters in the 300 block of Ezzard Charles because of a suspicious package.
The package in question was found on a FedEx truck, and that prompted the evacuation of District 1, Taft High School, a nearby visual arts school, and more.
Bomb and drug-sniffing dogs were used as well.
At about 6pm, the area opened back up. Police say the suspicious packages had clothing inside.


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‘Crazy Love’ is the third track from Moondance, Van Morrison’s second proper solo release. Astral Weeks had appeared on Warner Bros. in November 1968; with Blowin’ Your Mind! a compilation of recordings Morrison had made for Bang Records, originally intended for release as four singles, but put out as an album in September 1967 by label head Bert Berns without Morrison’s consent.
Morrison’s dispute with Berns began as an artistic concern, Morrison unhappy with Berns’ attempts to steer him in the direction of chart music, and fearing that his songs were being overproduced. After the death of Bert, owing to a heart attack, in December 1967, Morrison’s relationship with Bang Records and Bert’s widow, Ilene, became more acrimonious. He was rendered unable to record new music, and prevented from playing in the clubs of New York, where he had been based – after moving from Belfast – since undertaking the Bang Records recordings the previous March. Also facing visa troubles, Morrison married and moved, around the turn of the year, from New York to Cambridge, Massachusetts.
It was in the clubs of Boston that Morrison honed the compositions that would appear on Astral Weeks. Warner Bros. in the meantime prised Morrison away from Bang Records, leaving a set of conditions between Morrison and his former label which he managed to disparagingly fulfil. However many of the songs on Astral Weeks – including most notably its two centrepieces, ‘Cyprus Avenue’ and ‘Madame George’ – had been born in Belfast; while ‘Ballerina’ stemmed from a stop in San Francisco during a tour of the United States, with his band Them, between May and June of 1966.
Following the recording of Astral Weeks, Morrison moved to upstate New York, near the town of Woodstock. It was here that he wrote much of Moondance, which was recorded at A & R Studios in New York City between August and December 1969, and would be released on Warner Bros. at the end of February 1970.
Lewis Merenstein had served as the producer for Astral Weeks, and worked with Morrison again for Moondance – although Morrison co-opted production responsibilities, and was ultimately listed in the album’s credits as ‘Producer’, with Merenstein given the title ‘Executive Producer’. In Ritchie Yorke’s Van Morrison: Into The Music, published in 1975, Morrison stated regarding the Moondance recording sessions, ‘no one knew what I was looking for except me, so I just did it’.
While Astral Weeks had received extensive critical acclaim upon its release – Rolling Stone even named it album of the year – the record had not proved a commercial success. Moondance – retaining Morrison’s richly exploratory vocal manner, his abstract imagery and the sense of spiritual yearning, but on an upbeat record, infused with R&B rhythms yet with a more discrete sound palette characterising each of its ten songs – established Morrison’s reputation as a major artist with a wide appeal. The album reached number 29 on the Billboard albums chart; and while Morrison has described himself as near-starving even after the release of Astral Weeks, Moondance provided him with the base upon which to build a lasting career.
Alongside Van’s voice, Moondance is defined by its rhythm section and horns. Merenstein had sought to reunite Morrison with the core musicians of Astral Weeks. These included guitarist Jay Berliner and percussionist Warren Smith, and bassist Richard Davis, who had previously worked, respectively, with Charles Mingus and Eric Dolphy. They had been significantly responsible for the free jazz sound of Astral Weeks; but Van declined to work with them on this second occasion. In came saxophonist Jack Schroer, guitarist John Platania, and keyboardist Jef Labes, who would become mainstays of Morrison’s band across the early 1970s, featuring as part of his Caledonia Soul Orchestra until the end of 1973.
Horns play a key part on the title track, but following its swinging jazz, the sweet soul of ‘Crazy Love’ sounds especially fine. ‘I can hear her heart beating / For a thousand miles’, Van begins; and while the gentle structure of the song foreshadows the title track of 1971’s Tupelo Honey, the falsetto he easily adopts looks forward equally to ‘Who Was That Masked Man’ from Veedon Fleece. Van inhabits the song, the closeness of his voice complemented by the distant cooing of the female backing vocals.
‘Come Running’, from the second side of the album, was the only single released at the time from Moondance (the track ‘Moondance’ was not released as a single until 1977). It came out in May 1970, with ‘Crazy Love’ as the B-side, and peaked at number 39 on the Billboard Hot 100. In the Netherlands however, the single was flipped, with ‘Crazy Love’ as the A-side and ‘Come Running’ on the reverse. The cover of the single featured Morrison in a thick sweater with his then-wife Janet ‘Planet’ Rigsbee, in a photograph taken by Elliott Landy: the official photographer of the 1969 Woodstock Festival, whose photographs featured on Bob Dylan’s Nashville Skyline as well as Moondance.
‘Crazy Love’ has been one of Van Morrison’s most covered compositions. Helen Reddy had a hit with the song on the adult contemporary chart in 1971, a feat which Aaron Neville would repeat in 1996; and Cassandra Wilson sang the track on the tribute album No Prima Donna: The Songs of Van Morrison, released in 1994. The song’s name was used for the title of Michael Bublé’s fourth studio album, released in 2009; with his cover version emerging as the album’s fourth single.
In June of 1989, Van Morrison and Bob Dylan performed ‘Crazy Love’ together atop Philopappos Hill in Athens. Dylan had just finished the European leg of his ‘Never Ending Tour’, performing the night before at Panathenaic Stadium; while Morrison was travelling with the BBC, filming for an Arena documentary which aired in 1991 under the title One Irish Rover – Van Morrison in Performances. Overlooking the Acropolis with their acoustic guitars, Morrison and Dylan played several of Van’s songs – Dylan was apparently adamant about not performing any of his own – including ‘Foreign Window’, ‘One Irish Rover’, and the Moondance opener ‘And It Stoned Me’.
In 2003, upon Morrison’s induction into the Songwriters Hall of Fame, Ray Charles this time accompanied Morrison on ‘Crazy Love’. Charles played piano and sang the first verse and chorus before Morrison made his entrance; and Charles later remarked that ‘It meant a lot to sing ‘Crazy Love’ on stage that evening. This duet appeared on Charles’ 2004 album Genius Loves Company.


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Ilayathalapathy Vijay heads Bollywood sooner than expected. Presently engaged with AR Murugadoss Thuppaki, Vijay was approached by Prabhu Deva recently. The choregrapher/director asked him do a cameo appearance in his new Bollywood release, to which Vijay obliged whole-heartedly.
Prabhu Deva who is directing Bollywood action hero Akshay Kumar, had recently performed at the IPL 5 inaugural ceremony in Chennai. Those who saw his performance had no doubt, that Prabhu had his dancing boots still shining bright. His forthcoming movie titled Rowdy Rathore has Sonakhi Sinha and Akshay Kumar in lead. Co produced by Sanjay Leela Bansali and UTV Motion Pictures, the film is a remake of Siruthai. We came to know that the song ‘Jinthatha Jintha Jintha Jinthatha tha’ from the film is taken up Bollywood too. Prabhu came up with this brilliant idea of getting Vijay on board for a special appearance in the song. All three of them Akshay, Vijay and dancemaster Prabhu Deva hit the dance floor for this Bollywood release. A birdie tells us that Vijay din’t take any payment in cash or cheque and he did it just for Prabhu. Rowdy Rathore hits theaters Jun 1st. Check out the exclusive pics, as the three musketeers have some fun.


Application of CAD/CFD/RP-technologies for development of LVAD systems
MATEC Web of Conferences
The important problem of new Left Ventricle Assist Device (LVAD) systems development is to determine their hemodynamic and functional characteristics and reduce the design time. An effective method for achieving this is the use of approaches based on the application of CAD/CFD/PR-technologies. Methods of computer modelling were applied to determine the geometrical parameters of the blood pump, and methods of finite element analysis were used for the optimization of hemodynamic parameters of the
... c parameters of the LVAD system. The geometrical modelling was carried out in the Pro/Engineer WF5. The CAE-system Ansys was used to analyze the blood flow in the chamber of the pump. The motion of the flexible walls was simulated by normal flow through rigid walls. At the final stage some models were prepared for prototyping. The critical parameters of hemodynamic gave the possibility to optimize the shape of the blood pump. The LVAD system and its components were made using various RP-technologies. The hydraulic tests for the performance investigation and the analysis of implantability for implantable systems were carried out for manufactured prototypes of LVAD systems. The manufactured components of the LVAD system are completely operability and give the possibility to estimate the critical hemodynamic and functional parameters of the LVAD system.


Myanmar's new stock exchange came into existence Wednesday, but there are no listed companies or brokers and therefore no trading as well. When trading begins, foreigners won't be allowed to participate. Proponents say it's nevertheless important to start, to accelerate economic change alongside the country's expected shift to a democratic government next year. In another sign of change, the U.S. on Monday lifted for six months its ban on U.S. companies using Myanmar's ports.
State-owned Myanmar Economic Bank, Japan's Daiwa Securities and Japan Exchange Group, operator of the Tokyo Stock Exchange, put up $24 million to form Yangon Stock Exchange, CNBC reported. There are no rules yet on company disclosures, shareholder votes and annual meetings. The 10 brokerages with conditional licenses aren't ready to operate, Reuters reported. These don't faze the government's stock exchange point man.
"It doesn't necessarily mean that at the opening day, trading must start," said Deputy Finance Minister Maung Maung Thein, according to Reuters. "This is the right time. If we do not start now, it will be too late."
Six companies are in line to list in Myanmar, but after opening in recent years, exchanges in Laos and Cambodia each have less than five listed companies, Reuters reported.
"The economic potential is different," Maung Maung Thein said. "We don't compare."
Myanmar has a $65 billion economy compared with Cambodia's $17 billion and Laos' $12 billion, according to the Association of Southeast Asian Nations data.
The U.S. ban on dealing with the port operator has put American companies at a disadvantage compared with Japanese and European competitors in entering one of Asia's last large frontier economies, the Wall Street Journal reported. Because of alleged ties with the military junta, the port operator is on a U.S. government blacklist and companies that deal with it face sanctions. Fearing sanctions, Citigroup Inc., Bank of America Corp. and other banks have avoided offering trade financing to companies since discovering the port operator is blacklisted, Reuters reported.
Trade financing assures a U.S. company that it will get paid once its shipment reaches Myanmar. According to the Journal, minus trade financing, U.S. exports to Myanmar have dropped and U.S. companies operating in Myanmar -- which include Gap, General Electric Co. and Coca-Cola Co. -- have been asking the U.S. government to address this for months.
“We were concerned that U.S. banks out of fear of sanctions risk, out of increasing compliance costs and burdens, would decide to pull out of the market entirely if we didn’t move forwards with a holistic solution that would clarify the operating picture,” a senior U.S. government official told the Journal.
The opening of the stock exchange and the temporary lifting of the sanctions on dealing with the port operator come a month after Aung San Suu Kyi's National League for Democracy swept parliamentary elections. She has since met President Thein Sein and military commander Min Aung Hlaing, who assured her that they will turn over power in March. The assurance is important because after she won the 1990 elections, the military refused to step down, instead putting her under house arrest for most of the next 20 years.
Back at the stock exchange, Serge Pun, head of First Myanmar Investment Co., one of the companies that have applied for listing, is raring to be the first.
"We are ready," he told Bloomberg.


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Jackâ€™s interpretation of the song â€œThe More I Seek Youâ€written by Zach Neese not only caught my attention but immediately inspired me catching me up in rapturous praise!Â Singing like this not only lifts your spirit, but feeds your soul and this boy had accomplished both through this one video performance.
I have always been moved by worship music!Â Not just good gospel, but songs that allow you to feel the anointing which is undoubtedly heaven sent to the original authors.Â Jack not only sang this song with expression but you could feel a special anointing that was transmitting through him in this special and moving rendition.
Having my interest peeked even more about this young singer who so eloquently displayed a talent beyond his years, I was impressed to write his parents to find out more about Jack, his talent, aspirations and dreams for the future.
His parents shared with me that from the time Jack was born he was drawn to music.
â€œAny time we sang to him, he would turn toward our voices and became still and listened. When he was able to sit up, he would sway and bounce to the music playing on a video or the CD player.â€
They also added that if the tempo or song changed, Jack would demonstrate perfect rhythm.
In my research over the years I have found that musical prodigies often come from families who have already shown previous musical abilities.Â While it is not always the case that their birth parents show signs of musical ability, somewhere down through the gene pool this talent has been handed down.
Not only can Jack sing spiritual songs but he really shows his ability to deliver on this classic balled by Paul McCartney “Yesterday”
It’s been a little over two years since we have had the opportunity to feature Daves Highway here on Rivenmaster’s Place!
Their first appearance here was back in November of 2009 along with a very well received article published on The Skykid.com the following January which I entitled “Mississippi Music Magic“.Â Since that time, this Tremendous Trio has been spreading their musical magic worldwide and have amassed more than Forty One Thousand fans on their Facebook Fan Page alone!Â This does not even begin to account for the thousands of fans who do not use Facebook!Â They recently shared in a newsletter that their videos published by Godvine.com had been viewed nearly 2 Million times!
In addition to this great success they also launched 2 CDs recorded in Nashville, their latest being their first full length CD entitled
They have also made numerous Television appearances,Â performed with famous musicians, and held many concerts across the U.S.
Commonly labeled as sibling internet sensations, Daves Highway is Delaney, Zachary, and Erika Daves from Jackson, MS.Â The group has developed an authentic sound that includes a mix of gospel, country, folk and rock music.Â Â And, theyâ€™ve enjoyed sharing their story and their lives with all who might listen.
We caught up with Daves Highway earlier this month and asked them about some of their thoughts and plans for the future.Â The following is the results of that Q&A:

domain: entertainment


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Supplementary MaterialsSupplemental data jciinsight-1-86667-s001. those of mice receiving excipient. Uncultured CB Compact disc14+ monocytes accelerated remyelination also, but to a smaller level than DUOC-01 cells significantly. Microarray evaluation, quantitative PCR research, Traditional western blotting, and stream cytometry confirmed that appearance of elements that promote remyelination including PDGF-AA, stem cell aspect, IGF1, MMP9, MMP12, and triggering receptor portrayed on myeloid cells 2 had been upregulated in DUOC-01 in comparison to CB Compact disc14+ monocytes. Collectively, our outcomes present that DUOC-01 accelerates human brain remyelination by multiple systems and could end up being beneficial in dealing with demyelinating conditions. Launch Microglia play important but incompletely grasped jobs in propagation and quality of central anxious system (CNS) accidents. These cells modulate neuroinflammation, generate elements that regulate actions of astrocytes, oligodendrocytes, and Novaluron neurons, and apparent debris to supply a host for oligodendrocytes to begin with to remyelinate neurons (1). In mice, microglia occur from a distinctive pool of replicating precursors in the mind that’s originally produced from the extraembryonic yolk sac early in fetal advancement (2). Bone tissue marrowCderived, circulating bloodstream monocytes constitute another potential way to obtain infiltrating phagocytic cells that may exacerbate or ameliorate CNS harm (3). Although a pathway for flow of monocytes between lymph and human brain parenchyma has been defined (4), many circulating monocytes usually do not enter the uninjured, adult mouse human brain but may infiltrate the CNS pursuing Nrp1 insult such as for example human brain irradiation (5, 6), chemotherapy or damage (7), demyelinating circumstances (8), or chronic tension (9, 10). In a few versions, these infiltrating bloodstream monocytes may activate irritation and take part in demyelinating events (11, 12). In others, blood monocytes may facilitate remyelination (13, 14). Limited information is available concerning the role of human blood monocytes in the dynamics of repair of brain injury. Circulating human monocytes include subpopulations that differ in their ability to migrate to tissues, proliferate, and form inflammatory Novaluron or reparative macrophages at sites of injury (15). Based on experiments in rodents, several groups have proposed that cell products composed of human monocytes could be considered as candidates for the treatment of injury-induced CNS demyelination (16, 17). CD14+ monocytes present in human umbilical cord blood (CB) are among these candidates. CB mononuclear cells are protective in several in vitro culture and animal models of CNS injury (analyzed in ref. 18), and CB Compact disc14+ cells are crucial for the defensive capability of intravenously injected CB mononuclear cells in the rat middle cerebral artery occlusion style of stroke (19). We’ve created DUOC-01 lately, a cell therapy item made up of cells with features of macrophages and microglia that’s intended for make use of in the treating demyelinating CNS illnesses. DUOC-01 is produced by culturing banked CB-derived mononuclear cells (MNCs). The motile, phagocytic cells in DUOC-01 exhibit CD45, CD11b, CD14, CD16, CD206, ionized calcium binding adaptor molecule 1 (Iba1), HLA-DR, and iNOS, secrete IL-10 and IL-6, and upregulate the secretion of cytokines in response to TNF- and IFN- (20). DUOC-01 cells derived from genetically normal donors also secrete a battery of lysosomal hydrolases that are missing in children with leukodystrophies, and the initial DUOC-01 clinical trial (“type”:”clinical-trial”,”attrs”:”text”:”NCT02254863″,”term_id”:”NCT02254863″NCT02254863) is usually evaluating the security and feasibility of treating pediatric leukodystrophy patients with the product in the setting of systemic allogeneic CB transplantation. The trial was designed so that DUOC-01, administered intrathecally, can provide cross-correcting normal enzyme to slow neurodegeneration before definitive engraftment by wild-type enzymeCproducing cells from your systemic CB transplant. Studies of the biological activities of DUOC-01 suggest that it may modulate ongoing disease in other Novaluron ways that could expand the potential therapeutic use of DUOC-01 to other demyelinating conditions (20). The studies explained in this report were designed to provide proof of concept.
Supplementary MaterialsSupplementary Information 41467_2019_8871_MOESM1_ESM. tired (PD-1+Eomes+T-bet?) BM-TSCM predicts relapse. Accordingly, leukemia-specific T cells in patients prone to relapse display exhaustion markers, absent in patients maintaining long-term CR. These results spotlight a wide, though reversible, immunological dysfunction in the BM of AML patients relapsing after HSCT and suggest new therapeutic opportunities for the disease. Introduction In patients affected by high-risk hematological malignancies, such as acute myeloid leukemia (AML), allogeneic hematopoietic stem cells transplantation (HSCT) represents the most effective treatment option. Still, disease relapse and progression remain the major causes of treatment failure1. HSCT efficacy largely relies on the ability of donor T cells to eliminate residual tumor cells, through a phenomenon described as Graft-versus Leukemia (GvL) effect2. Durable immunosurveillance after HSCT likely requires long-term persistence of such leukemia-reactive T cells, possibly managed by a stem-cell-like memory T-cell pool3,4. Indeed, according to the hierarchical model of Borneol T-cell differentiation5, after antigen encounter, naive T cells differentiate into several functional subsets, including central memory (TCM), effector memory (TEM), and terminal effectors (TEMRA). Memory stem T cells (TSCM)6 are a recently defined subset that differentiate straight from naive T cells upon TCR engagement and wthhold the capability of self-renewal also to hierarchically differentiate into all the storage T-cell subsets7,8. Clonal monitoring of genetically customized T cells infused into sufferers suffering from malignant and nonmalignant diseases revealed the power of TSCM to persist for many years in the web host also to recapitulate the ontogeny of circulating storage T cells9,10. When immune system reconstitution is certainly conserved and preserved long-term after transplant Also, leukemic blasts can get away the immune system response by many mechanisms11. On the tumor cell level, a combined mix of genomic instability and a Darwinian procedure for immunoselection may eventually result in a lack of tumor immunogenicity. For example, by Borneol monitoring sufferers relapsing after mismatched HSCT, we defined the increased loss of the hosts mismatched HLA haplotype by leukemic cells as another biological mechanism resulting in tumor get away and scientific disease recurrence12,13, regular in past due relapses14 particularly. Alternatively, the current presence of tolerogenic Tregs or cells expressing inhibitory ligands such as PD-L115 may result in the loss of donor-mediated antitumor activity. In the last years, the expression of multiple inhibitory receptors around the cell surface of antigen-experienced T cells has been associated to T-cell exhaustion, a functional status characterized by concomitant loss of cytokines production, proliferative capacity, and lytic activity16. First explained in Borneol chronic infections, T-cell exhaustion is considered a common and relevant phenomenon in malignancy progression, as well demonstrated by the efficacy of immune checkpoint-blocking therapy, a paradigm-shifting treatment for several tumors17. In the setting of leukemia, a pioneering study reported the efficacy of anti-CTLA-4 blocking antibody as a treatment of post-transplantation relapse18. However, data around the role of immune checkpoints in the control of hematological malignancies are still limited. In the current study, we investigated whether T-cell exhaustion is usually involved in the development of post-transplant leukemic relapse. To this end, we evaluated the expression of several inhibitory receptors on different bone marrow (BM) infiltrating memory CD4+ and CD8+ T-cell subsets in AML patients who received HSCT. We discovered a PD-1+?TIM-3+?KLRG1+?2B4+?exhaustion personal that characterizes early-differentiated Compact disc8+ TCM and BM-TSCM subsets, during disease relapse. Outcomes Increased regularity of BM-Tregs affiliates to AML relapse We examined BM and peripheral bloodstream (PB) from 32 sufferers suffering from AML who received HSCT from either HLA-matched (20 pts) or HLA-haploidentical (12 pts) donors. Clinical features of sufferers are summarized in Desk?1. Samples had been gathered at relapse (REL; median 251 times after HSCT; 16 pts) or, for sufferers who attained and maintained comprehensive remission (CR; 16 pts), at 12 months after HSCT. Examples from 11 healthful donors (HD) had been used as handles. The gating technique from the flow-cytometry PVRL3 analysis is certainly reported in Supplementary Fig.?1. After transplant, T cells infiltrating the BM (BM-T cells) of sufferers in CR shown an.
Supplementary Materialsoncotarget-11-1737-s001. this inhibitor acts through a system of conformational modulation of LMO2. Significantly, this ongoing function provides resulted in the id of a little molecule inhibitor from the SCL-LMO2 PPI, which can give a Gap 27 starting place for the introduction of brand-new agents for the treating T-ALL. These total outcomes claim that equivalent techniques, predicated on the modulation of proteins conformation by little molecules, may be used for healing targeting of various other oncogenic PPIs. and [16, 28, 29]. Within this structural construction, we have utilized a combined mix of biophysical and biochemical ways to display screen for little molecules with the purpose of developing substances which can particularly inhibit the SCL LMO2 PPI. Utilizing a homogeneous time-resolved fluorescence (HTRF) assay we’ve determined a dose-responsive strike substance (3K7), which inhibits the SCL-LMO2 PPI = 4. In further tests we dealt with the specificity from the 3K7 relationship with LMO2. MST tests were repeated to look for the affinity of 3K7 for the various other 3 known people from the LMO family members: LMO1, LMO3 and LMO4. LMO2 stocks ~50% series homology with LMO1 and LMO3, and 40% with LMO4. The crystal buildings of LMO2 [28, 31] and LMO4 [37, 38] demonstrated solid structural homology of the average person LIM domains (128 residues superimposing in a RMSD of 2.7 ?) and even more intensive structural homology is certainly anticipated between LMO2, LMO3 and LMO1. Through the functional viewpoint, LMO1, LMO2 and LMO3 have already been connected with T-ALL and haematopoiesis, whilst LMO4 is certainly functionally even more divergent. The MST analysis showed no conversation between 3K7 and LMO1, Gap 27 LMO3 or LMO4 (Physique 4). Taken together our data show that 3K7 forms a direct and specific conversation with LMO2. Open in a separate window Physique 4 3K7 does not bind to other LMO family proteins.Curves showing normalised fluorescence data from MST experiments looking at 3K7 binding to LMO1 (pink), LMO3 (blue), LMO4 (violet). Error bars represent standard deviation, = 3. 3K7 induced conformational switch in LMO2 comparable to SCL-binding deficient mutant To further elucidate the potential mechanism of 3K7-mediated inhibition of the SCL-LMO2 Gap 27 conversation, we set out to investigate the impact of 3K7 binding around the conformational flexibility of LMO2. Previously published crystallography data [16, 28] revealed large movements around a conserved hinge (F88) between the LIM domains. Mutation of the hinge residue (F88D) exhibited that this residue is absolutely required for binding of LMO2 to its partner protein SCL/TAL1 and for the function of this complex As this residue is located in proximity of the SCL interface, it is possible that mutation Gap 27 of this residue disrupts the binding surface. Another possibility is usually that a mutation in the hinge region affects the accessible conformations of the proteins. The result from the F88D mutation on LMO2 conformation was explored using little angle X-ray scattering (SAXS) to see the proteins in option [39, 40]. First of all, round dichroism spectroscopy (Compact disc) determined the fact that F88D is certainly soluble and properly folded without significant deviation noticed in the WT profile recommending no adjustments in the supplementary structure (Body 5A). Next, WT and F88D had been put through SEC-SAXS to acquire information on the form and how big is these protein. With a Kratky representation to judge the flexibleness and globularity, we discover that LMO2 and F88D possess equivalent scattering profiles and so are multidomain protein connected with a versatile linker (Body 5B). Analysis from the pair-wise length distribution function P(r) nevertheless, showed a lower life expectancy in the utmost Rabbit Polyclonal to GFP tag length (Dmax) of F88D (Body 5C) and of the computed radius of gyration (Rg) (Desk 2) when you compare F88D to LMO2, recommending the fact that mutant proteins typically adopts a far more constrained conformation. The info therefore shows that the F88D mutation causes modulation from the LMO2 conformational versatility. Open up in another home window Body 5 3K7 induces a noticeable transformation in LMO2 conformation much like LMO2-F88D.(A) Comparison from the far-UV Compact disc spectra for LMO2 (green) and F88D (grey) displays profiles in keeping with folded protein containing equivalent supplementary structures elements. (B) Kratky plot of the solution scattering showing broad bell-shaped curves common of elongated, flexible protein molecules (green: LMO2; gray: LMO2-F88D; light blue: LMO2+ 1.5x 3K7; reddish: LMO2+3x 3K7). (C).
This study focused on applying different high hydrostatic pressure + skin tightening and (HHP + CO2) processing conditions on refrigerated (4 C, 25 days) farmed coho salmon (= 10) were averaged. adjustments had been assessed by colorimetric evaluation with the next guidelines: lightness (L*), reddish colored/green (a*), and yellowish/blue (b*). The CIE L*, a*, and b* color coordinates (taking into consideration regular illuminant D65 and observer 10) had been determined. The tests had been performed in triplicate. The colorimeter yielded L*, a*, and b* ideals for each place, which were transformed into a complete color difference worth (?E) from ?E = (?L*2+?a*2+?b*2)0.5. All measurements had been performed at space temp (20 1 C). 2.5. Microbial Evaluation and Shelf-Life Estimation All examples had been examined for the real amount of mesophilic and psychrophilic aerobic microorganisms, spp., and lactic acidity bacteria (Laboratory). From each test, 20 grams was aseptically acquired and homogenized with 180 mL chilled optimum recovery diluent (Oxoid, Basingstoke, Britain) inside a filtration system stomacher bag utilizing a Stomacher 400 Circulator (Seward Lab, London, UK) at 230 rpm for 2 mins. Further decimal dilutions had been ready with the same diluent and analyzed for aerobic mesophilic and psychrophilic microorganisms , LAB , , and spp. . The presence of was tested at the end of the storage period . Microbial data were transformed into logarithms of the number of colony-forming units (log CFU/g). The detection limit was 10 CFU/g (1.0 log CFU/g), except for Pseudomonas, which was 100 CFU/g (2.0 log CFU/g). When no colonies were detected, an arbitrary value of 0.5 log CFU/g was assigned, except for spp., which was allocated a value of 1 1.0 log CFU/g. Microbiological shelf life was determined according to the description by Reyes et al.  in which growth curves of experimental data were fitted to the reparametrized version of the modified Gompertz equation to estimate growth kinetic parameters, including shelf life . To estimate shelf life, a 6.0 log CFU/g maximum limit of acceptability for mesophilic and psychrophilic microorganisms was considered. This value is commonly used for fish species because it correlates with the onset of unpleasant odor and taste [29,30,31]. 2.6. Statistical Analysis of Quality Parameters The statistical analysis of experimental data was determined with the Statgraphics Plus? v.5.1 software (Statgraphics Corp. 1991). An analysis of variance (ANOVA) was applied to estimate any statistically significant differences at a 95% confidence level ( 0.05) together with a multiple range test (MRT) to compare data. 3. Results and Discussion 3.1. Enzymatic Activities The enzymatic activities of coho salmon fillets are shown K02288 inhibitor database in Table 1. It is worth mentioning that, according to the properties of CO2, this allows a substantial inactivation of enzymes at relatively mild operating conditions in which the thermal treatment is not effective . In addition, the CO2 gas is also non-toxic, nonflammable, inexpensive, and is easily removed simply by depressurization K02288 inhibitor database and outgassing . Table 1 Effect of treatment and refrigerated storage time on enzyme activity of coho salmon fillets. 0.05). Different uppercase letters indicate significant differences among days of storage ( 0.05). The protease activity of the control sample was 0.397; immediately after the treatments (non-assisted CO2 and HHP-assisted CO2), this activity was reduced by approximately 30%, 50%, and 60% for RGS11 the 0/50, 0/70, and 150/100 treatments, respectively. Despite this reduced activity on day 0, protease activity values did not show a clear design during storage space from day time 3 to day time 10. Consequently, protease activity on day time 10 was regarded as the final storage space bring about which remedies 0/50, 0/100, and 150/70 could maintain decreased protease activity by around 50% to day time 10. From a statistical perspective, ANOVA results looking at protease activity ideals at a 95% self-confidence level showed a substantial influence from the remedies upon this parameter K02288 inhibitor database ( 0.05). An MRT.

domain: medical


text:
Europe is a fantastic continent to visit. Each country is very different, which means that there is always something new to enjoy, especially if you visit the major cities.
This is certainly true of Austria and its beautiful capital, Vienna. It has a unique ambience, which leaves a positive impression on most people who stay there.
The chance to enjoy some culture
Perhaps the nicest thing about Vienna is its old school charm. The city has many formal traditions that have not changed for hundreds of years. Of course, this is true of many places, but Vienna is different.
In Vienna, they do not just dress up in traditional costumes for the odd festival. Far from it, every day, there are old-fashioned formal events going on.
Refreshingly, the Viennese are not just putting on a show for the tourists. Culture really is a part of their everyday life. Importantly, they want visitors to the city to enjoy these events too. You are more than welcome to attend these special events as well. It is easy to pick up opera tickets from viennaoperatickets.com, or attend one of the many balls or concerts that are held in the city.
The opportunity to enjoy Austrian wine
If you love wine, Vienna is a good base. On a daily basis, bus tours run from the city to the wine taverns of the Wachau Valley, Gobel and Heuriger Wieninger. For those visitors who do not fancy spending the day outside the city this 3-hour wine walk provides an alternative way to learn more about local wines and enjoy tasting them.
Enjoy some indie shopping
For those who like to shop the Neubau district is a wonderful place. It is home to an amazing array of shops selling unusual items that you just do not see elsewhere.
Exceptional Christmas markets
Christmas markets are popular in many large European cities, but nobody does them as well as Vienna does. For most stallholders selling good quality products is important, so they are a great place to enjoy tasty festive food, pick up special presents and some nice festive decorations.
Great food and drink
Austria is not widely known for its cuisine, but it should be. In Vienna, you get to enjoy the best of what the country has to offer. The coffeehouses have been serving perfect coffee and divine pastries, for centuries. They offer a coffee drinking experience that is every bit as good as that found in Italy.
At the Nashmarkt, you can enjoy a beer and go to Umarfisch where you point at the fish and it is cooked in front of your eyes. You should also try Kaiserschmarrn and Millirahmstrudel. The residents of Vienna simply will not put up with poor quality food, so it is very unusual to be served a poor meal in the city.
These are just my favourite reasons to stay in this beautiful city. There are many more. Vienna really is well worth a visit.

domain: travel


text:
- Active Time 20m
- Total Time 20m
Makes 4 servings
- 1 tablespoon olive oil
- 1 small red onion, chopped
- 1 clove garlic, chopped
- 2 teaspoons chopped fresh ginger
- 1 large ripe avocado, or 2 small avocados, peeled and pit removed
- 1 tablespoon fresh lemon juice
- 1 cucumber, peeled, seeded and diced
- 2 tablespoons chopped fresh chives
- 1 1/2 cups chicken broth, chilled
- 1/3 cup nonfat sour cream
- 1/2 teaspoon salt
- 1 tomato, seeded and chopped, as a garnish
In a saute pan over medium heat, heat the olive oil. Add the onion and cook for 2 minutes. Add the garlic and ginger and cook, stirring, for another minute. Remove from the heat and set aside.
Chop the avocado, place in a bowl and toss with the lemon juice. In a food processor, puree the avocado and cucumber until smooth. Add the sauteed onion mixture and the chives and process again.
Transfer the avocado mixture to a large bowl. Stir in the chicken broth and sour cream until smooth. Season with salt. Chill the soup thoroughly in the refrigerator.
To serve, garnish with the chopped tomato.
Recipe reprinted by permission of Doubleday. All rights reserved.
nutrition information per serving
200 calories; 16g total fat; 9mg cholesterol; 370mg sodium; 12g carbohydrates; 6g fiber; 6g protein
These nutrition facts are calculated according to the ingredients listed in this recipe. Any substitutions will change these facts. Although we strive for accuracy, please note that food manufacturers occasionally change their food formulas, which could affect the calculations as shown.
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By Jason Powell, Prowrestling.net Editor (@prowrestlingnet)
Jason Powell hosts the Prowrestling.net Free Podcast and reviews WWE Smackdown Live: Final hype for WWE SummerSlam with AJ Styles and Samoa Joe, Carmella, Charlotte, and Becky Lynch, a lengthy video recap on The Miz and Daniel Bryan’s history, and more (23:21)…
Click here to stream or download the August 14 Free Podcast – Powell’s WWE Smackdown audio review.
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The new edition of the Pro Wrestling Boom Podcast with Jason Powell and guest Jim Ross on his role in AEW, Tony Khan as a leader, whether Ross knew Shawn Spears was going to hit Cody with a chair shot to the head, working with Excalibur and Alex Marvez, his new book and speaking engagement deal, and much more... Search "Pro Wrestling Boom" in Apple Podcasts or any podcast app to subscribe.


text:
Professional Fire Fighters Of Wisconsin
Membership Assistance Program
Ø Stress is a part of everyday life, but the stress encountered by emergency response personnel is greater than stress associated with everyday life events.
Ø When stress levels become too high and usual coping fails, negative complications can develop that adversely affect job performance and your personal life as well.
Ø Sometimes it is helpful to have someone to talk to … who will listen and understand.
Ø The Membership Assistance Program is a resource through which members can voluntarily seek confidential referral and support from fellow emergency responders who have been trained as a Peer Support Team member.
- Because of the success of this program and the Peer Support Team members, this team was invited to New York City following the attack on the twin towers and to Louisiana after Hurricane Katrina to provide support to emergency responders in these areas.
Ø If you have any questions about the program please contact: Allison Lancione M.S., Licensed Professional Counselor (IT) at firstname.lastname@example.org
Ø For confidential assistance please contact any member of the Peer Support Team listed on the attached PDF. Please do not hesitate.
Ø This program is an alternative for PFFW members seeking assistance, BUT is NOT meant to replace professional help.

domain: psychology


text:
There are more than 7,000 rare diseases affecting patients in the United States. From arthrogryposis to Zellweger syndrome, they are each so uncommon, most of us will never encounter any of them. The same is true for most pediatricians and adult physicians. But there’s a place where rare diseases aren’t so extraordinary: Shriners Children’s.
In the last 10 years, Shriners Children’s has treated more than 27,000 patients with rare diseases. In addition, clinicians and researchers associated with Shriners Children’s have published more than 250 studies examining several dozen rare diseases.
Rare Conditions Treated at Shriners Children’s
|Number of patients (since 2012)
|Acute Respiratory Distress Syndrome
|Amniotic Band Syndrome
|Arthrogryposis Multiplex Congenita
|Bruck Camurati-Engelmann Syndrome
|Cauda Equina Syndrome
|Congenital Insensitivity to Pain
|Cubital Tunnel Syndrome
|Duchenne Muscular Dystrophy
|Fragile X Syndrome
|Hereditary Multiple Osteochondroma
|Juvenile Paget/Paget Disease
|Multicentric Carpotarsal Multiple Pterygium Syndrome
|Nail Patella Syndrome
|Postural Orthostatic Tachycardia Syndrome
|Spinal Muscular Atrophy
|Staphylococcal Scalded Skin Syndrome
|Superior Mesenteric Artery Syndrome
|Tethered Cord Syndrome
|Thrombocytopenia Absent Radius Syndrome
While Rare Disease Day is marked February 28 on the calendar, Shriners Children’s provides care to children with rare medical conditions every day of the year. We’re often told that patients don’t feel different at Shriners Children’s because they see so many others like themselves when they are here.
Special kids finding their way to Shriners Children’s
Children with rare diseases find their way to Shriners Children’s in many ways. Some already know their diagnosis and seek out our well-known care providers to treat their uncommon conditions. Others come because their condition has specific symptoms that our providers can help with.
“We see a good number of children who don’t come to Shriners Children’s for their primary diagnosis,” said Marc Lalande, Ph.D., Shriners Children’s Vice President of Research Programs. “They might have a syndrome that isn’t considered an orthopedic disorder, but rather is neurodevelopmental, such as Rett syndrome or Prader-Willi syndrome. They come to us at Shriners Children’s because there are secondary skeletal issues, often involving the spine, that we can treat.”
Others, like Nathan, come to us seeking answers they can’t find elsewhere. When Nathan was 9, he started having pain in his knee. In addition, because one of his legs was shorter than the other, he had problems walking. That sparked Nathan’s mother, Blanca, to go on a year-long journey to figure out the cause of Nathan’s trouble.
Nathan was first seen at a Chicago hospital, where doctors could not diagnose or treat his condition. As his pain and walking difficulties worsened, Blanca wasn’t sure where to go. Eventually, the family landed at Shriners Children’s Chicago.
After four months of testing, the medical team there was able to pinpoint the root of Nathan’s problems: He was diagnosed with Morquio syndrome.
Morquio syndrome is a rare, genetic metabolic disorder that affects about 5,000 children nationwide. People who have this condition are unable to process certain types of sugar molecules, which affects the growth and development of the spine, bones and organs.
Now 14, Nathan is doing well. To treat his condition and prevent the disorder from progressing, he receives an IV infusion weekly. The care and answers they found at Shriners Children’s convince Blanca and Nathan that he has a bright future ahead.
Specialists providing world-class care
Spina bifida is a birth defect in which an area of the spinal column doesn’t form properly, leaving a section of the spinal cord and spinal nerves exposed, which often results in damage to the spinal cord and nerves. Only 1,400 babies are born in the U.S. each year with spina bifida, and there are fewer than 125,000 spina bifida patients in the country.
More than 7,000 of those patients have been seen at Shriners Children’s in the last 10 years. Mohammed is one of them.
Fleeing war and family tragedy in their native Iraq and then Syria, Mohammed and his family arrived in the U.S. when he was 4. Habitat for Humanity helped the family settle in Sacramento, California. They didn’t know Shriners Children’s Northern California was there, or that it has one of the top spina bifida programs in the country, led by Maya Evans, M.D.
“It was meant to be that we came to Sacramento,” said his father, Bassam. “It was fate.”
Now 12, Mohammed loves basketball, the Sacramento Kings and hanging out with his friends. He attends middle school and uses a wheelchair to navigate his everyday life. Bassam credits Dr. Evans and the Shriners Children’s team for connecting the family with every resource possible that’s given him the ability to live a more independent life.
Over the years, Mohammed has undergone multiple surgeries to correct deformities in his lower leg, foot and spine. When he was 11, he underwent a spinal procedure and received a halo traction device that uses gravity and a patient’s own body weight to straighten the spine.
Although Mohammed spent many long and difficult days in the hospital for his surgeries, he is someone who sees the bright side of every situation. “I always looked forward to seeing the child life specialists on the second floor and seeing other kids,” said Mohammed. “We played lots of video games like NBA2K and air hockey. Not to brag, but I’m pretty good at air hockey.”
That’s not the only sport he excels in, though. He is the only student in his school district who plays basketball from a wheelchair. His team created a special play for him called the Mohammed Shield. The play calls for his four teammates to form a square around him, while he drives to the basket, shoots and scores.
“It’s the best,” said Mohammed. “I love basketball, that’s all I want to do. I want to go pro one day.”
Researchers forging the path for future patients
Shriners Children’s clinicians and researchers are dedicated to not just treating children who have rare diseases, but to conducting research to learn new knowledge about these conditions that will lead to more effective treatments and better outcomes for these patients. Because Shriners Children’s sees so many patients with rare diseases, our teams are in a unique position to collaborate in research across the healthcare system.
What began as a small research effort with a budget of $12,000 is now a sophisticated, multimillion-dollar program with international recognition. Over the years, Shriners Children’s researchers have made significant breakthroughs in many of our areas of specialty care. At the Shriners Children’s Genomics Institute, researchers are working to discover genetic causes for diseases and conditions and use the knowledge to create personalized therapies.
At Shriners Children’s, “rare” means extraordinary. And that’s how we make our patients and their families feel. Providing the most amazing care anywhere and committing to the endless search for better treatments and outcomes, we treat each patient for being as exceptional as their diagnosis.


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text:
After all that has happened in the flight between Sunil Grover and Kapil Sharma, the stars of ‘The Kapil Sharma Show’ have come out supporting the former. The comedians Ali Asgar and Chandan Prabhakar have apparently left the show, showing which side they stand by.
But there has been a star Kiku Sharda aka Bumper- the nurse from The Kapil Sharma Show, who has neither left the show nor made any statements over the brawl between his co-stars.
Recently in an interview with Pinkvilla, Kiku Sharda opens up by saying: “Firstly what does balancing both the shows mean?! Like what are these ‘both the shows’?! The one that I am going to do with Sunil is a one off thing just for a day unlike a series of episodes. It was planned three months in advance. It absolutely has got nothing to do nothing with the controversy stating both Sunil and Kapil. Three months ago we agreed to do a show in Delhi with these two characters. So there is nothing as such, there is no connection with my one off with Sunil and the controversy. It’s sad to know people are thinking this way. To make it clear, the one with Sunil is a one off thing and I am doing only one show, The Kapil Sharma Show.”


text:
After unveiling the renderings of the Samsung Galaxy S23 and Galaxy S23 Plus, The source OnLeaks released the renderings of the Galaxy S23 Ultra. As you can see from the renderings, the Samsung Galaxy S23 Ultra looks a little different from the previous generation, with a similar design.
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It is reported that the device is provided with a 6.8-inch micro-curved screen with a size of 163.4 x 78.1 x 8.8mm, which is slightly wider than the 163.3 x 77.9 x 8.9mm of the Samsung Galaxy S22 Ultra.
OnLeaks says the Galaxy S23 Ultra will have the narrowest bezels ever seen in a Samsung Galaxy S-series phone. While the dimensions remain the same, the Samsung Galaxy S23 Ultra will bring improvements in peak brightness, color accuracy, minimum screen reflectivity, and HDR performance.
As can be seen from the rendering, the power button and volume button of the phone are located on the right side of the phone, and the speaker opening, USB-C interface, SIM card slot, and S Pen slot can be seen at the bottom, and it is equipped with a center punch lens.
In addition, the Samsung Galaxy S23 Ultra has made the two small lenses on the right side of the rear lens flush with the fuselage. In addition, the side transition of the fuselage is no longer a semicircle, which may be to increase the holding area of the hand.
The revealer @Ice Universe previously broke the news that the biggest change in the Samsung Galaxy S23 Ultra is the increase in the width of the middle frame, which reduces the curved part of the screen and will be closer to the micro-curved screen, which is consistent with the new rendering.

domain: design


text:
Digital Archive brought to you
by JPMorgan Chase & Co.
Mrs. Ethel Sebastian requests that Dr. King assists in the search of her father, whom she has never met. Mrs. Sebastian provides facts and details to better aid Dr. King's pursuit of locating her father. She also mentions her cousin, a Reverend, who is a member of Friendship Baptist Church. Mrs. Sebastian is aware of Dr. King's hectic schedule and sends her blessings in hope that he can locate her family relatives.
Dr. King gives an address commemorating the one hundredth anniversary of the passage of the Emancipation Proclamation. In the celebratory speech, he calls all Americans to take action in applying the principles of the Emancipation Proclamation to society. Dr. King states that the commands of the Proclamation have fallen short in practice and that it will take a cumulative effort from every citizen to undo this process.
Dr. King breaks down the structure of a nonviolent movement. He describes at length the difference between "token" integration and true integration. He describes three types of violence that could be used to achieve integration to which he prefers the "wholesome," nonviolent choice. Lastly, Dr. King gives his opinion on the "evils" of war.
Dr. King was the recipient of this correspondence from Harold Fey, Editor of 'The Christian Century.' Mr. Fey acknowledged Dr. King's article "How My Mind Has Changed" and raised one concern of why Dr. King didn't mention his stabbing incident, in the article. He referenced Paul in the Bible by quoting Galatians 6:17, "I bear on my body the marks of Jesus." 'The Christian Century' published the article "How My Mind Has Changed."
In this first of a two-part article for the New York Amsterdam News, Dr. King writes about the circumstances surrounding SCLC’s decision to develop Project C, a campaign confronting racial injustice in Birmingham. Three factors led to the decision. First, the city was the home of the Alabama Christian Movement for Human Rights, SCLC’s strongest affiliate. Second, Birmingham represented the hard-core segregationist South. And third, the South’s largest industrial center was suffering economically from the loss of vital industry and its poor image on race relations.
Rev. C. J. Bell, the Editor in Chief of the Alexandria News Leader and pastor of the Progressive Baptist Church, wrote this letter to Dr. Ralph David Abernathy expressing his support following Dr. King's assassination. Abernathy was named Dr. King's successor as president of the SCLC and Bell wishes to offer his help if he can be of service.
Justice Felix Frankfurter is quoted by the Boston Sunday Globe to discuss the lack of liberty in history due to repulsive individuals. The American Civil Liberties Union is accused of being communist as well as Jefferey Gordon, a member of the pro-Peking Progressive Labor Party. The article expounds on various organizations and quotes surrounding their political perspective.
Crozer Theological Seminary, Dr. Kings alma mater, issues a solicitation for contributions to its almnus. The letter states that alumni receiving the letter were not able to be reached during the "Crozer Alumni Telethon." Dr. King attended the religious institution from 1948-1951 after receiving his Bachelor of Arts in Sociology from Morehouse College.
Robert S. Bilheimer, Associate General Secretary for the World Council of Churches, invites Dr. King to attend a consultation on Christian Practices and Desirable Action in Social Change and Race Relations.
The Child Development Group of Mississippi is being terminated by the Office of Economic Opportunity. This is not because the program isn't valid but because it would disturb the balance of politics in Mississippi. Klein and Saks, Inc. has helped keep the program alive. The goal of the program was to provide education, medical assistance, and nourishment for preschool children and their families.
Rev. John Bartos referenced Dr. King's book, "Strength to Love," in his sermon to the First Baptist Church congregation. Rev. Bartos focused on the chapter "Being a Good Neighbor," in which Dr. King discusses a story of a car accident and the discriminatory triage process that contributed to the occupants' deaths. The sermon produced questions and reactions the writer is hoping Dr. King can address.
John Wooton expresses the commitment of the Negro Industrial Economic Union towards the efforts of Reverend Jesse Jackson and SCLC's Operation Breadbasket.
Monica Wilson, from the School of African studies at the University of Cape Town, writes Dora McDonald expressing joy and excitement that Dr. King accepted the invitation to deliver the Davie Memorial Lecture. Wilson states that while King's accommodations are taken care of, the school cannot possibly pay for his aide.
Upon return to the US after receiving the Nobel Peace Prize, Dr. King was awarded the City of New York Medallion of Honor by Mayor Robert Wagner. This document is a program from the event, "Salute to Rev. Dr. Martin Luther King, Jr." It lists the featured speakers and entertainment.
In this letter Myron A. Hoyt, of the Synod of South Dakota, sends a financial contribution to the SCLC and comments on Dr. King's reaction to the Black Power Movement.
Dr. King writes notations regarding the Supreme Court's decision in 1954 of Brown versus Board of Education, listing the various positive and negative aspects of that decision. The Reverend closes by stating, "Let us go and unite and be inspired once more..."

domain: library


Miguel Aragón places an enlarged, cropped version of a found newspaper photograph over a copper plate; he drills through it, then uses the copper to print the black-and-white image. An anonymous face—a corpse—becomes abstracted close up, made visible only through distance yet understood only with close study.
Aragón, from Ciudad Juarez, a Mexican border city known for fatal drug-cartel violence, has seen endless pictures of deceased bodies. The repetition of similar events, the sights of similar bodies, desensitizes us—as one face morphs into another, and as together they morph into shapes, abstractions, and numerical data, the very real loss of individual human life is forgotten. By transforming and re-presenting the image, the artist heightens its impact. Its reality, and our own mortality, is seen and recognized anew. Aragón wants us to understand the deaths of people—regardless of their sins or innocence—in border-city drug wars in human, rather than numerical or notional, terms.
Does the truth of the violent scene of a murdered corpse disappear behind the intricacy of an artwork, or reemerge through it? And who is being appeased—as the work’s title Aplacado suggests—by this image?
From the exhibition: Other Side:
Art, Object, Self (August 12, 2017 – January 3, 2018)


Just three days after a group of 10 travellers' caravans and motorhomes took over a section of the Boating Lake car park in Cleethorpes, some have now relocated at Tesco.
Around six or seven vehicles now occupy a section of the Cleethorpes branch of the supermarket near to the hedging which runs parallel with Grimsby Road. The vehicles are parked lengthways across several parking bays rather than following the painting guidance lines for each bay.
Some of the vehicles do appear to be the same ones which had parked up only a couple of miles down the road at the end of January.
As previously reported, parking wardens placed tickets on the vehicles parked alongside the caravans at the Boating Lake and a number of refuse wheelie bins were provided by council staff.
North East Lincolnshire Council has been searching for a location to create a designated stopover site for the gypsy and traveller community but so far nothing has come to fruition.
A Tesco’s spokesperson said: "We’re aware of the caravans in the car park and are working to resolve the situation as quickly as possible."