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Leopard Print Drawstring Joggers
Be cool and stylish in these Leopard Print Drawstring Joggers. Featuring an elasticated drawstring waistband, pockets, tapered leg and a cropped length, you'll look great and find comfort all day. The leopard print design adds a trendy look.
Style & Fit:
- Elasticated drawstring waistband
- Tapered leg
- Cropped length
Why we love it
How to style it
Fit and sizing
Material and care
Order before 12:30pm for next day delivery. T&C's apply
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domain: design


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Few months back a video circulated on social media, in which Darlings actor Vijay Varma and actress Tamannaah Bhatia were spotted kissing. It was being claimed that the video was taken on New Year’s Eve in Goa, where both celebrities were present. Everyone was intrigued by this, wondering how they got together in the first place.
Vijay and Tamannaah Spotted On Cosy Dinner Date
Tamannah and Vijay’s dating rumours don’t seem to be going away anytime soon. The duo was recently photographed together for a dinner date, and fans can’t stop talking about it. The rumoured couple was spotted in a car while coming out of a restaurant in Mumbai.
Does Vijay and Tamannaah have made their relationship public
Recently, Vijay uploaded a photo with a red heart emoji on his Instagram story. Two sets of feet are shown in the image, standing together. Vijay’s story caught everyone’s attention, and fans found out that it was Tamannaah and Vijay’s shoes.
The image clearly showed Tamannaah’s jacket, and they immediately discovered another image of the actress clutching the exact same jacket.
Vijay and Tamannaah Spotted Together
The rumoured couple was once more photographed by paparazzi, and this is the first time they have been seen together since the video went public. Tamannaah and Vijay made it a point to wave at the photographers even though they didn’t pose together for the pictures.
Prior to this, both actors posed for photos holding hands at an event and were photographed. Fans were persuaded that both of them were madly in love after they even hugged one another.
Who is Vijay Varma?
Vijay Varma is an actor, and he works mostly in the Hindi film industry. Varma was born on March 29, 1986, in Hyderabad, Telangana. Vijay started his acting career in theater, and for the longest time in his life, he did theatre.
Vijay Varma Family
Varma’s father owns a handicraft business in Hyderabad, and there is not much information available online about his mother. He also has two elder siblings, one elder brother, Manoj Varma, and one elder sister, Shobha.
Vijay Varma Education
Varma did his primary and secondary schooling in Hyderabad itself. Later, he did his B.com. from Hyderabad. In 2005, Varma applied to the Film and Television Institute of India (FTII) and was selected. At FTII, Vijay pursued graduation in acting.
Vijay Varma: Career
Varma started his career as a theatre artist in Hydrabad; later, he moved to Mumbai; and in between these two places, he did other jobs as well. Before intending to relocate to Pune for two years to pursue a formal acting degree at FTII, he worked in a number of plays.
Vijay made his debut with a short film named “Shor” in the year 2008. Later, he was featured in other films like Chittagong, Rangrezz, and Gang of Ghosts. But Varma started getting recognition after he was featured in the 2016 movie Pink.
Vijay did other films like Raag Desh, MCA, Manto, Gully Boy, Super 30, Baaghi 3, and Yaara. In 2022, Vijay was seen playing the lead role in Darlings alongside Alia Bhatt.
Varma has been featured in various web series as well, like Cheers-Friends, Reunion, Goa, A Suitable Boy, She, Mirzapur, and OK Computer.
Vijay Varma’s Net- worth
Vijay Varma has been in some of Bollywood’s best films, and he is very much in demand these days. Apart from acting, Vijay is also a model, and we can assume that his net worth could be anywhere between INR 18 and 20 crore.
What is Vijay Varma’s notable work?
Vijay is one of the most underrated artists in the industry, and he always outshines his roles. Some of his notable works include Pink, MCA, Gully Boy, Super 30, A Suitable Boy, She, Mirzapur, and Darlings.
Vijay Varma: Girlfriend
It is rumored that Vijay Varma is dating actress Tamannaah Bhatia. Recently, the couple was spotted partying together in Goa. Although the couple has not given any confirmation about the rumors regarding their relationship.
Vijay and Tamannah Bhatia Age Gap
The rumoured girlfriend of Vijay Varma was born on December 21, 1989, and she is currently 33 years old. Vijay Varma, on the other hand, was born on March 29, 1986, and is 36 years old. The age gap between the couple is 3 years.
Vijay Varma FAQs
Ans. The debut movie of Vijay Varma was Shor in the year 2008 and it was a short-film.
Ans. Vijay Varma was born on March 29, 1986, and is 36 years old.
Ans. Vijay Varma is the youngest and have 1 elder brother and sister.
Ans. Mirzapur, Darlings, Gully Boy, etc.
Ans. Vijay Varma was born in Hyderabad, Telangana.

domain: celebrity


text: The Cashs Jordan Bowl takes the design story from the bible. The people camped one night at Gilgal, about two miles away from Jericho. Joshua took the 12 stones they had brought and stacked them into a memorial. He told the nation it was a sign to all the nations of the earth that the God had parted the waters of the Jordan, just as he had parted the Red Sea in Egypt. The bowls design follows the idea of the rocks placed in the waters of the river Jordan.

domain: geography


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Last Updated: 2021-03-01 by Lorna Terry

domain: pet


Big Fish Audio Syntron-X
But if that does sound like your kind of thing you're in for a treat.
With 23 construction kits, various drum kits, arpeggios, beats and robotic vocals to play with, this is sure to be a useful tool for anyone making music with a heavy fringe/Electro inﬂuence.
The only potential weakness here is that the samples are so deﬁnitively '80s-sounding that they aren't very versatile - every track you make using these will probably end up sounding like a long-lost Human League B-side.
Is that a bad thing? Only you can tell.
Great for electro.
If you want to create post-'80s electro music, this is for you!
• 2.8 GB on disc (1.08 GB of 24bit WAV content) 916 WAV loops and hits on disc • Construction Kits folder contains 23 kits from 80 to 180 BPM • Arps folder contains 15 arp synth loops • Drum Kits folder contains four drum kits each containing from 30 to 60 hits • Efx Beats Folder contains 25 bonus beats • Rezo Vox and Vocoder Vox each contain 165 vox words and phrases


It looks as though this La Niña could be weak and short-lived. But those with long memories will recall the last La Niña summer was also expected to be short — yet the flooding came regardless.
- The current La Niña is looking relatively short and weak, likely to peak in late spring or early summer
- But it is not the only factor that could push us towards wet conditions in the coming months
- With catchments already so wet from the past few years of rain, flooding cannot be ruled out this summer
So how long and strong will this La Niña be and should we expect more flooding?
"At the moment, this La Niña isn't looking particularly strong and it's looking like it will peak probably fairly early in the summer or late in the spring," according to Andrew Watkins, head of long-range forecasting at the Bureau of Meteorology.
"Which is a little bit unusual, a little bit different to the La Niñas that we've been seeing in recent years."
La Niña and El Niño events usually start in winter end in autumn or thereabouts.
But Dr Watkins said a number of models from around the world were in fairly close agreement that we can expect to see a peak in the La Niña before the end of the year.
"Quite often we see a range of the different forecasts, but the consistency between the models makes us fairly confident that we'll see an earlier peak than in recent years with this event," he said.
Andrea Taschetto, associate professor at the University of NSW Climate Change Research Centre and ARC Centre of Excellence for Climate Extremes, has also been looking at the international climate model outlooks.
"In November, all of the seven models cross this threshold for La Niña," she said.
"In December, those models already start to show a retreat of these temperature anomalies and only four of the seven models indicate La Niña conditions."
By January, it would be down to three and by February the temperatures were basically within the neutral range, with the exception of just one model.
Not only is it is expected to be short, the La Niña is also expected to be relatively weak.
But before you go resting on your laurels, there is a bit more to it.
How accurate can we be?
The La Niña and El Niño declarations can make it seem as though they are black and white, but, in reality they, are messy natural processes that play out a bit differently every time.
"The forecasts aren't perfect. It's not that easy to forecast the progression of La Niña and El Niño events," according to climate scientist Andrew King from the University of Melbourne.
"We don't have a really complete understanding of the dynamics of them, which limits our ability to really forecast them very well," he said.
La Niña and El Niño result from a complicated interaction between the deep ocean, the ocean surface and the atmosphere.
The limited historical data available makes it even more difficult to decipher trends and how it all works.
"It's often said that we know less about the ocean than we do about the surface of planets," Dr King said.
Dr Taschetto points out that there are many factors that influence the onset and duration of El Niños and La Niñas.
There are some patterns, but even then there are quirks. For example, she says predicting when a La Niña will end is more difficult than with an El Niño.
"The reason for that is because the El Niño southern oscillation is an asymmetric phenomenon, meaning that El Niño and La Niña years are not exactly the mirror image of each other," she said.
"With El Niño, because there is a reversal or weakening of the cycle when it gets closer to our monsoon season, what we see is a reversal of the winds and that can help to reverse the anomalies.
"But as a La Niña is basically a strengthening of the normal conditions it's slightly harder to predict the termination."
Is there a difference within La Niñas?
Generally, stronger La Niñas bring wetter weather to eastern Australia.
According to Dr Taschetto, the relationship between La Niña and rain in eastern Australia is actually stronger than with El Niño.
"A large La Niña event is generally linked to a larger Australian rainfall response.
"While the strength of an El Niño event sometimes it's not as good an indicator to tell us how dry Australia will be."
But Dr King points out it is an indication, not a guarantee.
"Hopefully, if we have a mild La Niña, we don't have the super wet conditions but it's not a perfect correlation.
"There are other things going on in the climate that affect us in Australia," he said.
This spring, those other things are also pushing us towards rain.
Even if the La Niña is weak, both the currently negative phase Indian Ocean Dipole to the west and the positive phase of the Southern Annular Mode in the south, are ramping up the moisture.
When and if they decline as we get to summer there are still other drivers and weather events such as cyclones that could pump in the moisture.
Can we rule out flooding this summer?
In a word; no.
"We can't rule out flooding, especially as catchments are still pretty full and the soils are still pretty wet, especially below the surface," Dr King said.
"Even fairly typical summer rainfall patterns could result in some flooding.
"The forecasts indicate a probable mild La Niña but if they're slightly off and actually it turns into a stronger La Niña or it lasts longer, that does heighten the risk of more severe flooding. So we should be prepared for that possibility," he said.
Dr Taschetto agreed that the past two years of rain and floods have set up a precarious situation this year.
"We are in a very delicate condition even with a weaker La Niña," she said.
"It has set the scene for increased rainfall this spring, and we need to keep an eye on what the weather systems now are doing to determine where the risk of floods are higher."
Dr Watkins reiterated that even if things were to ease off in terms of rainfall, conditions could still be dangerous.
"Remembering that in any northern wet season, which is traditionally the higher risk weather season for Australia, you do have tropical lows, you do have tropical cyclones, you can get the monsoon coming further south at times," he said.
"So, even in the normal summer, we're going to have wet periods, particularly in parts of northern and eastern Australia.
"If they coincide with areas that are already very wet, the flood risk is elevated."


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The quickest and easiest way to cook corn on the cob. Nuke it in the microwave! And there's NO shucking it or pulling all those annoying sticky hair things out! It's the only way I'll cook corn from now on.
- Fresh corn in the husk
- Butter and Salt, for serving
Cooking time 5mins
Simply microwave corn in its husk on High for about 4-1/2 minutes.
Remove from microwave with an oven mitt. With a sharp knife, cut off the stalk end of corn. Using the oven mitt, hold the corn upright, squeeze downward, pushing it out the cut end. Voila, perfectly cooked ready-to-eat corn, with NO silks to remove! Pass the butter, please!
Short 1-minute How-to video-->

domain: food


Japanese Casino Legislation On Target; Organized Crime Gets Shut Out It’s been decades in the making, but Japan spurred on by the promise of this 2020 Tokyo Summer Olympic Games appears to be finally making a real push towards legalizing land gaming within the island nation. News reports from Reuters state a draft that is solid of gambling policy has been put together, and Japan’s Diet (parliament) may be reviewing before year’s end for very early 2014 passage, Jesus willin’ and the crick don’t rise. Baby Procedures Towards Legalization At Last Even though that occurs on schedule, however, it would take another two years for the legislators to drum up a more in-depth overview that is regulatory which in turn would at long last open the road towards bonafide legal casinos to start being built. The objective, of course, being to own everything up and ready to roll with time for those tourists that are all-important manage to drop some chunks of change if they come to Japan for those summer games. As we’ve been ad that is seeing of late, corruption, crime and gambling appear to often rest within the same sleep together, and with an eye towards trying to stem that tide before the tsunami comes in, Japanese lawmakers are building some interesting safeguards in their casino regulations. These generally include producing a gambling that is independent who in change oversee the license application process, since well as making it mandatory for any licensees to have a decade’s worth minimum of their tax, banking and credit information on almost all their top-level executives readily available for review. And not soleley the actual execs, but most of the executives’ family will also be scrutinized, presumably so no-one can hide anything by putting it in a partner’s or sibling’s or son’s or daughter’s title. Oversight Group Will Be Cabinet-Level The regulatory body will probably be set as a de facto case group, with all the aim it not beholden to any particular Japanese ministry in its dealings for it being to make. That, in turn, is supposed to minimize the likelihood for graft or coercion by some of the mob that is japanese the so-called ‘Yakuza’ organized crime syndicates whom might try to get their arms into the casino cookie jar. In presenting the plan’s principles, legislators said the idea that is overall to make sure ‘the hurdles to enter the business should be set high … With proper regulation and enforcement … there is no reason for gambling enterprises to become hotbeds of unlawful activity.’ Also in the start-up proposal that is regulatory demands limits to be set on how many casinos can be approved into the initial phases, to make certain that regulations will be enforced and the overall impact among these entities on the population at big is assessed. And while well-known alternatives of major centers that are metropolitan as Tokyo and Osaka will most likely be the very first locales for these new appropriate gambling enterprises, there are also provisions within the plans to make sure that some smaller towns could additionally be taken into consideration for future tasks. Buyers and Sellers Dance the Dance with Atlantic City Casinos Everybody wants a bit of Atlantic City’s casinos these full days, it seems Ah, the Atlantic Club in Atlantic City: the girl that everybody wants to sleep with, but no body shall marry. This nj-new Jersey land gaming joint keeps on finding brand new suitors, however, and now an one that is new popped up on the horizon: a local attorney-slash-entrepreneur, George Miller, who’s developed an investment team utilizing The Flynn Company CEO Kevin Flynn of Philadelphia. Apparently, this property duo are eyeing all types of East Coast casinos, with the goal of firming something up before New 12 months’s 2014 strikes midnight in the clock. Atlantic Club Just One Contender While Miller won’t come right away and say who is looking like they will be getting a diamond just yet, he did tell the Press of Atlantic City their team hasn’t eliminated the Atlantic Club as being a contender, but that they were ‘looking all over the area’ for just the spot that is right make their deal. The situation is created a bit more interesting in that both Miller and Flynn hold very small stakes in A caesars-run pennsylvania property; albeit only a 0.25% stake each. Press of Atlantic City interviewer Donald Wittkowski suggests that this minor alliance could help the duo, as Caesars has four casinos in Atlantic City and could be prepared to part with one. You may recall that Caesars’ international debt-load is sky-high, and some cash right now might be a lot more than welcomed as some of their records are coming due in 2015. Rumors are that possibly Trump Plaza, Golden Nugget and Revel along with Caesars’ Showboat might all be getting glances that are sexy Miller and Flynn right now. An abundance of Inventory Up for Grabs It looks like it’s a sellers market these times, though; additionally in line to buy something in Atlantic City likely to then get in position to get a gaming that is interactive for AC’s imminent Internet launch are outfits like PokerStars, possibly Kentucky’s Churchill Downs horse racing operation, and also Philly’s SugarHouse casino owners are said to be looking to expand to the Atlantic City market. British operators 2UP video Gaming is additionally reported to be thinking about AC, backed evidently by the unnamed mogul that is asian. One of the properties letting it be known they might be available for the proper price are the now-infamous Atlantic Club, the Plaza (which killed a potential cope with the western Coast’s Meruelo Group for $20 million when the casino’s main mortgage holder Carl Icahn stated ‘I do not think so’ to the low-ball offer), along with the Golden Nugget and poor ol’ Revel, which simply can’t seem to stand up, it’s therefore debt-heavy during the top. Of course, you may wonder why a town whose casinos are doing this generally speaking awful within the net profits department is being therefore eagerly courted by a lot of these days, and the apparent response is both the interactive gaming potential (you can’t obtain an online operator’s license without owning a land casino) also as the seemingly vague potential for the legalization of sports betting in Atlantic City’s land casinos, that has been shot down more times than an Iranian war air plane over the White home. Regardless, Miller claims their investment group is doing its due diligence relating to this market. The past few years, he claims he sees ‘a great deal of good on the horizon. despite Atlantic City’s crappy profit ledgers’ Caesars Entertainment Rearranges Deck Furniture for Debt Restructuring Caesars Entertainment is doing plenty of restructuring, but will it assist their financially sinking ship? Can this level of Titanic debt be salvaged from dragging the ship to your bottom regarding the ocean that is financial? That is the question being asked as Caesars Entertainment Corp. put Planet Hollywood one of the kingpin Las Vegas Strip properties in to a new holding company, along with the Interactive Division and the still-being-built Horseshoe Casino Baltimore. The business has instructed its shareholders they have only until Oct. 17th to obtain in for a stock fire sale to generate $1.18 billion in much-needed cash infusions as well. And you thought your storage sales were busy. Shareholders Should Buy Stocks First The Securities and Exchange Commission (SEC) filing created by Caesars announces that shareholders will get very first dibs on one share each of the newest Caesars Acquisition Co. (CAC) for each share of this existing parent company they own. This restructuring is in the works because this past Spring, and ended up being officially approved by the Nevada Gaming Control Board in July. Under the restructuring, the newly created CAC will be a partial owner of the also newly created Caesars Growth Partners, and along with Caesars Entertainment (are you dizzy yet?), the brand new entity will acquire Planet Hollywood, the Baltimore under-construction property, and Caesars Interactive Entertainment, which, of course, spearheads the World Series of Poker (WSOP) a real income online poker brand that just lately launched for Nevada Internet players. Now you might think the point of all this fundraising is to pay down the organization’s massive current debt, but apparently, these are typically studying the White House financials, because they say the raised funds will go towards new casino tasks in the U.S., as well as more online development, along with 888 Holdings, to get a few on-line casino web sites up and rolling in New Jersey whenever that state goes online on November 26. They must be in a pissing competition with Obama for the greatest achievable debt ceiling. Gambling’s Highest Debt Load Think we are kidding? Caesars has the dubious honor of holding the casino industry’s highest-ever long-term financial obligation load at $23.5 billion. In early 2014, they will perform a refi of about $5 billion of that, and got about $200 million towards that amount in a stock purchase already. This somewhat scary debtload doesn’t appear to be deterring anyone from teaming up with the gaming behemoth though; Detroit-based Rock Gaming is in on a joint venture with Caesars to own and operate the $400 million Horseshoe Baltimore once it’s completed and ready to start in 2015. And Suffolk Downs Racetrack in Boston moved into partnership with the business because well, as they make an effort to manage to get thier $1 billion casino project accepted and built in Boston in Massachusetts’ Battle regarding the Casino Giants game. Tends even Caesars Deputy General Counsel Michael Cohen isn’t totally sure about this restructuring gameplan, but. ‘Compared to our capital structure, that isn’t a big change,’ he told the Nevada Gaming Control Board about the company’s spinoff concept if they signed down on the plan in July. ‘Caesars has a complete lot of debt. We think it is manageable, but others disagree.
ï»¿Japanese Casino Legislation On Target; Organized Crime Gets Shut Out< It’s been decades in the making, but Japan spurred on by the promise of this 2020 Tokyo Summer Olympic Games appears to be finally making a real push towards legalizing land gaming


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HUGE 4 INCH DUAL OUTLETS!


text:
There was pandemonium at the popular Area 1 roundabout Abuja when suspected thugs loyal to the embattled Senator Dino Melaye (APC, Kogi West) rescued him and whisked him to safety from the fully armed Special Anti-Robbery Squad.
The drama which began at 2.10 pm lasted for about six minutes with the suspected thugs in two Hilux pick up double-crossing the police escort, jerked up Melaye and threw him into one of the vans and speed off.
Commercial taxis and other motorists were caught unawares when the four vehicles carrying Melaye stopped at the middle of the road.
It was when some of the officers numbering over a dozen came down to transfer the senator, who was observed engaging in scuffles with the officers, into another vehicle that the crowd gathered.
Melaye was practically seen resisting his being moved into another vehicle, he later felled on the ground and was heard shouting, “You must shot me, you must kill me here, I am not going with you to Kogi or anywhere.”
Despite the efforts of three of the police officers to lift Melaye, wearing a brownish trouser and a shirt to match, he resisted kicking and engaging in scuffles even while on the ground. He was also not wearing a shoe.
It was at this time that three of the suspected thugs all wearing black vest and trousers struck from nowhere and lifted the Senator off the ground and threw him inside one of the vans which immediately sped off with passersby hailing him and shouting ‘Dino, Dino….’
The Police Officers who seemed paralyzed with shock could not instantly chase the fleeing van with their prized target.
It took some seconds for the officers to recover from the shock and sped after the van which took off to Finance-Berger junction in Zone 7 Area of the FCT.
The Police Officers initially threaten to shoot anyone who dared to record the drama or take pictures with their phones and even charged at some passersby. They however did not shot or arrest anyone.
It was when they realized that some people at the upside of the junction were recording that they lower their guards and it was at that instance that Melaye was snatched from the ground and whisked away.
Melaye has been having a running battle with the Kogi State Governor, Yahaya Bello.
The embattled lawmaker’s house was besieged by the Police and it took several hours of interventions and negotiations before he submitted himself to the police outside his Maitama, Abuja, home.
He had claimed that the team of mobile and regular police officers, who arrived to arrest him at Monday afternoon, wanted to kill him, insisting he had done nothing wrong.
The police said they were after Melaye for allegedly arming deadly criminal gangs and convening a political rally that ended with the death of at least one person.
He was also accused of providing false statement to the police when implicated the chief of staff to Kogi governor in an alleged attempt to assassinate him last year.
Mr Melaye denied the allegations, saying his ordeal was largely because of his outspoken stance against alleged impunity in the country.
He also accused his state governor Yahaya Bello, as the mastermind of his predicament, a claim the governor denied. Mr Bello said Mr Melaye should face the consequences of his actions.

domain: politics


Astronauts set up a brand new photo voltaic panel close to the Worldwide House Station – Spaceflight Now
NASA astronauts Josh Casado and Frank Rubio headed close to the Worldwide House Station on Saturday for a seven-hour spacewalk to put in and deploy a brand new deployable photo voltaic array just lately delivered by a SpaceX cargo ship.
Casado and Rubio, each of their first spaceflights, started their spacewalk on Saturday at 7:16 a.m. EST (12:16 GMT). The official begin of the tour was marked when the astronauts switched their spacesuits to battery energy.
Astronauts moved from the Quest area station’s hatch to starboard, or proper, of the lab’s solar energy farm, the place the station’s robotic arm positioned two new ISS Roll-Out Photo voltaic Array, or iROSA, models earlier this week after eradicating them from the trunk of a SpaceX cargo capsule Dragon. The Dragon spacecraft delivered the photo voltaic panels to the area station on November 27, together with a number of tons of supplies and experiments.
The brand new blankets of photo voltaic cells had been wrapped round coils and unfurled like a yoga mat, as soon as mounted on a mounting bracket on Starboard 4, or S4, the area station’s energy farm part, which is greater than the size of a soccer area finish to finish. to the tip.
Initially, the astronauts labored to take away one of many two newly delivered iROSA models from its provider by loosening the bolts and restraining the launch. Casada took a place on a leg restraint on the finish of a Canadian-made robotic arm and held the photo voltaic coil by hand whereas the arm moved it towards the S4 truss.
Two astronauts positioned the iROSA unit on a mounting bracket pre-positioned in the course of the earlier spacewalk. They deployed the iROSA unit on a hinge, then put in bolts to safe it in place. Cassada and Rubio mixed electrical connectors to attach the brand new iROSA unit to the area station’s electrical system. They then related a Y-cable to direct the vitality generated by each the brand new deployable photo voltaic cell and the unique S4 photo voltaic panel into the lab’s energy grid.
A mounting bracket connects the brand new arrays to the station’s energy ducts and swivel joints that maintain the photo voltaic wings pointed on the solar because the spacecraft races round Earth at greater than 17,000 miles per hour.
The Worldwide House Station has eight energy channels, every of which is powered by electrical energy generated from a single photo voltaic array wing that extends from the station’s spine. The brand new photo voltaic array deployed on Saturday will produce electrical energy for the area station’s 3A energy channel.
The unique photo voltaic panels had been launched throughout 4 area shuttle missions between 2000 and 2009. As anticipated, the effectivity of the station’s authentic photo voltaic panels has deteriorated over time. NASA is upgrading the area station’s energy system with new retractable photo voltaic arrays — at a price of $103 million — that may partially cowl six of the station’s authentic eight photo voltaic panels.
When all six iROSA models are deployed on the station, the ability system will likely be able to producing 215 kilowatts of electrical energy to assist at the least one other ten years of science operations. The improve will even accommodate new business modules which are deliberate to be launched to the area station.
The primary pair of recent retractable photo voltaic arrays had been launched to the area station final 12 months and had been put in above the station’s oldest set of authentic photo voltaic panels on truss part P6, situated on the far left finish of the outpost’s energy truss. Two extra iROSA pods are scheduled to launch on SpaceX’s resupply mission subsequent 12 months.
The brand new photo voltaic panels had been equipped by NASA Boeing, Redwire and a bunch of subcontractors.
After the brand new iROSA unit was mechanically and electrically built-in into the station’s S4 truss, the astronauts launched the clamps that held the photo voltaic cell to the coil within the launch configuration. This allowed the blankets to step by step deploy, harnessing the pressure vitality within the composite rods that assist the photo voltaic blanket. The design of the deployment mechanism eliminates the necessity for motors to drive the photo voltaic array.
“He is beginning to transfer,” one of many astronauts radioed management, prompting applause from the assist group in Houston.
“It is unbelievable,” Casada mentioned. “Yeah, that is fairly cool,” Rubio interjected.
The carbon fiber assist booms had been untwisted in opposition to their pure form for storage throughout launch.
It took about 10 minutes for the photo voltaic array to deploy to its totally prolonged configuration, stretching about 63 toes lengthy and 20 toes extensive (19 by 6 meters). It’s about half the size and half the width of the station’s present photo voltaic panels. Regardless of their smaller dimension, every of the brand new arrays produces roughly the identical quantity of electrical energy as every of the station’s current photo voltaic panels.
After the blanket was deployed, the astronauts adjusted the strain bolts to safe the iROSA blanket in place.
The astronauts then headed again aboard the area station truss to arrange one other iROSA unit to be put in on the left part of the P4 truss in the course of the spacewalk tentatively scheduled for December 19.
After finishing their duties, Casada and Rubio returned to the Quest’s airlock and closed the hatch. They started depressurizing the airlolk compartment at 14:21 EST (1921 GMT), finishing a 7 hour 5 minute spacewalk.
Saturday’s spacewalk was the second of Casada’s and Rubio’s careers and the 256th spacewalk since 1998 in assist of constructing and sustaining the Worldwide House Station.
E-mail The writer.
Observe Stephen Clarke on Twitter: @StephenClark1.
#Astronauts #set up #photo voltaic #panel #Worldwide #House #Station #Spaceflight


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Ubiquitination controls the stability of most cellular proteins, and its deregulation contributes to human diseases including cancer. Deubiquitinases remove ubiquitin from proteins, and their inhibition can induce the degradation of selected proteins, potentially including otherwise ‘undruggable’ targets. For example, the inhibition of ubiquitin-specific protease 7 (USP7) results in the degradation of the oncogenic E3 ligase MDM2, and leads to re-activation of the tumour suppressor p53 in various cancers. Here we report that two compounds, FT671 and FT827, inhibit USP7 with high affinity and specificity in vitro and within human cells. Co-crystal structures reveal that both compounds target a dynamic pocket near the catalytic centre of the auto-inhibited apo form of USP7, which differs from other USP deubiquitinases. Consistent with USP7 target engagement in cells, FT671 destabilizes USP7 substrates including MDM2, increases levels of p53, and results in the transcription of p53 target genes, induction of the tumour suppressor p21, and inhibition of tumour growth in mice.
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We thank the Diamond Light Source for access to beamlines I03 and I04. We thank S. M. Boyd for providing Extended Data Fig. 4, and S. Suhrawardy, V. Smith and Z. Yu for help with experiments. Work in the D.K. laboratory is supported by the Medical Research Council (U105192732), the European Research Council (309756), and the Lister Institute for Preventive Medicine. Work in the B.M.K. laboratory was supported by a John Fell Fund 133/075, the Wellcome Trust (097813/Z/11/Z) and the Engineering and Physical Sciences Research Council (EP/N034295/1). L.S. received a stipend from North West Cancer Research.
A.P.T., W.W.K., A.C.L.M., L.M.T., N.J.E., C.A., F.S., M.S.P., T.M.R., L.M.D.S., S.B.M. and T.R.H. are employees of CRUK Therapeutic Discovery Laboratories. S.I., E.C.T., S.M.B., D.R.L., J.A.C., A.V.T., J.L., E.W., B.C.F., V.V.Z., A.C.T., A.J.B., M.W., C.L.M., C.G.M., M.S., J.A.E., K.W.B., C.J.D. and S.K. are employees of FORMA Therapeutics. This work was performed by the DUB Alliance and funded by FORMA Therapeutics.
Reviewer Information Nature thanks W. Gu and the other anonymous reviewer(s) for their contribution to the peer review of this work.
Publisher's note: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Extended data figures and tables
a, Schematic diagram of the USP7 constructs used in this study. b, Representative SPR sensorgrams of USP7CD and Akt Pleckstrin homology (PH) domain (negative control) to measure affinity parameters (Kd values) of FT671 and FT827. Compounds were tested in twofold dilutions from 50 μM FT827) or 1.56 μM (FT671). Sensorgrams are plotted showing two technical replicates. Data are representative of three biological replicates. Values in parentheses represent s.e.m. range. c, IC50 curves for FT671 against USP7C-term (open triangles) and USP7CD (filled squares) in the ubiquitin-rhodamine assay. The graph displays three biological replicates, each point representing the mean of three technical replicates. d, Time course of the inhibition of USP7C-term by the covalent inhibitor FT827 used to derive kobs values at each concentration (left). kobs plot for covalent inhibitor FT827 used to derive the kinetic parameters (right). 18 biological replicates were run individually, a representative biological replicate is shown.
a, Schematic representation of DUB activity-based profiling of small-molecule inhibitors. Compounds were incubated with either intact MCF7 cells (in situ) or crude cell extracts, followed by labelling with the active site DUB probe HA–UbC2Br. DUBs, either targeted by compounds or labelled by the DUB probe, were visualized by western blotting or subjected to immunoprecipitation for enrichment and analysis by quantitative mass spectrometry7,23. b–e, FT671 and FT827 selectively target USP7 and disallow HA–UbC2Br binding, but do not notably interact with other DUBs as assessed by anti-HA immunoblotting. One out of two independent biological replicates is shown. b, MCF7 cell extracts incubated with FT671. c, Intact MCF7 cells incubated with FT671. d, MCF7 cell extracts incubated with FT827. e, Intact MCF7 cells incubated with FT827. f, Immunoprecipitation of cellular DUBs captured by HA–UbC2Br labelling for 10 min after incubation of MCF7 cell extracts with DMSO, 1 μM or 10 μM of FT671 or FT827, or 50 μM P22077 for 60 min. Immunoprecipitated material was separated by SDS–PAGE and analysed by western blotting using the indicated antibodies. g, FT671, FT827 and P22077 were incubated with MCF7 cell extracts at the indicated concentrations for 60 min, followed by labelling with HA–UbC2Br for either 5 min (left) or 60 min (right). Samples were separated by SDS–PAGE and analysed by western blotting using the indicated antibodies. Uncropped images for gels are shown in Supplementary Fig. 1.
a–c, Stereo representation of 2|Fo| − |Fc| electron density maps, contoured at 1σ, covering all atoms of the inhibitors in each of the two independent USP7 molecules of the asymmetric unit. Protein is shown as in Fig. 2a, and compound carbon atoms are in yellow. a, FT671; b, FT827; c, FT827, in an orientation to show the covalent linkage between inhibitor and Cys223.
a, b, Compound interactions and surrounding residues are labelled, hydrogen bonds indicated, and residues shown according to their chemical properties (see key). The images were generated with Molecular Operating Environment (MOE) (v.2013.08, Montreal, Canada). a, FT671; b, FT827.
a, Superposition of the USP7–FT671 complex with indicated DUBs. Shown are the isolated cartoon structures that are shown superimposed in Fig. 3a, b. USP7 apo and USP7–FT671 (top left) show an identical switching loop position, whereas the corresponding region in other apo USP structures is in a distinct conformation that resembles the USP7~Ub complex (see Fig. 3a–c). Structures displayed: USP7 apo (purple, PDB code 1NB824); USP4 apo (PDB code 2Y6E40); yUBP6 apo (PDB code 1VJV); USP8 apo (PDB code 2GFO46); USP12 apo (PDB code 5K1647); USP14 apo (PDB code 2AYN48). b, Binding site detail, showing the interactions between palm subdomain Tyr residues (Tyr465 and Tyr514 in USP7) and the thumb subdomain and switching loop backbone present in all USP apo structures. The USP7 apo switching loop conformation disallows the Tyr465 interaction, which rotates away from the thumb subdomain, and allows Tyr514 to adopt a buried conformation (Tyr514 ‘down’ position). This generates space for compound binding. In other USP apo structures, the equivalent Tyr residues form hydrogen bonds with the thumb subdomain and occupy the compound binding site.
a–c, SPR-based binding of FT671 (a), FT827 (b) and ubiquitin (c) to indicated USP7 mutants. For compound binding to wild-type USP7CD and Akt-PH controls, see Extended Data Fig. 1b. Sensorgrams are plotted showing two technical replicates. Data are representative of three biological replicates. Values in parentheses represent s.e.m. range. d, Summary table of binding constants observed for experiments in a–c and Extended Data Fig. 1b. Biological repeats are indicated (n = 9 for USP7CD wild type, n = 3 for USP7CD mutants), and values in parentheses indicate s.e.m. e, Circular dichroism profiles of wild-type USP7CD (red), USP7CD(F291N) (orange), USP7CD(Q297A) (green), and USP7CD(Y465N) (blue); each experiment was performed in triplicate. f, Tabulated values for experiments shown in Fig. 3f. g, Structure of activated USP7. The switching loop in USP7 is a point of intrinsic allosteric regulation, provided by a C-terminal module of five ubiquitin-like domains (termed HUBL1 to HUBL5) followed by an activation peptide (amino acids 1084–1102)26 (see Extended Data Fig. 1a). In full-length USP7, the activation peptide stabilizes the active conformation of the switching loop in the ubiquitin-bound state26,27,28, and this can be modulated by USP7-activating proteins, such as GMPS26,29. Shown is the structure of activated USP7 bound to its C-terminal activation peptide. The model was generated from PDB code 5JTV27, and shown are the catalytic domain with ubiquitin in the S1 site (coloured as in Fig. 2a) of molecule 1 in the asymmetric unit and the HUBL5 domain and activation peptide (orange) of molecule 2 in the asymmetric unit, which in the crystal binds to molecule 1 in trans.
a, HCT116 cells were transfected with non-targeting control (NT1) or three different USP7-targeting siRNAs for 72 h, harvested and probed with indicated antibodies. A representative experiment from two biological replicates is shown. b, U2OS cells were transfected with a pool of four independent siRNAs targeting USP7 or a non-targeting control siRNA and processed as in a. A representative experiment from two biological replicates is shown. c, HCT116 cells were treated with 10 μM FT671 for 24 h and RNA was extracted for qPCR measurements with primer sets against indicated transcripts (see Methods). Data were analysed with the ΔCt method. Experiments were performed in triplicate. d, HCT116 cells were treated with FT671 (10 μM) for longer periods, harvested and probed with indicated antibodies. A representative experiment from two biological replicates is shown. e, Experiment as in Fig. 4d, with higher FT671 concentration. p53 levels are upregulated upon FT671 treatment in cells expressing GFP or GFP-tagged wild-type USP7, but not in cells expressing compound resistant mutants. USP7 expression was induced for 7 h by 1 μg ml−1 doxycycline, and cells were treated with 3 μM FT671 for the last 4 h before lysis. f, IMR-32 neuroblastoma cells33 were treated with indicated concentrations of FT671, and effects on p53 and N-Myc levels were tested by western blotting. A representative experiment from two biological replicates is shown. g, h, HCT116 (g) or MM.1S (h) cells were treated for indicated times with FT671, and western blotted for UHRF1 and DNMT1. Vinculin and β-actin serve as loading controls. A representative experiment from two biological replicates is shown. Uncropped images for gels are shown in Supplementary Fig. 1.
a, MM.1S cells were treated for the indicated times with 10 μM FT671, and proteins detected by western blotting with indicated antibodies (see Methods). A representative experiment from two biological replicates is shown. b, Meso Scale analysis (see Methods) measuring the ratio of ubiquitinated versus non-ubiquitinated MDM2 in MM.1S cells upon FT671 treatment and proteasome inhibition (25 μM MG132). c, MM.1S cells were treated with 10 μM FT671 for the indicated times and RNA was extracted for qPCR measurements with primer sets against indicated transcripts (see Methods). Data were analysed with the ΔCt method. Experiments were performed in duplicate. d, qPCR analysis as in c, using a single time point against MCL1 and MYC, which in this setting are not p53 target genes after 24 h of 10 μM FT671. Experiments were performed in triplicate. e, MM.1S tumour xenograft tissues were analysed for p53 expression by western blotting and normalized to the β-actin loading control. Uncropped images for gels are shown in Supplementary Fig. 1.
This file contains chemical synthesis of USP7 compounds. (PDF 630 kb)
This file contains annotated full gel blots for all figures in the main manuscript. (PDF 5083 kb)
This file contains DUBs identified by mass spectrometry after HA-UbC2Br labelling of MCF7 cell extracts. (XLSX 178 kb)
This file contains all proteins identified by mass spectrometry after HA-UbC2Br labelling of MCF7 cell extracts. (XLSX 3099 kb)
This file contains the sequences for any RNAi/small RNA constructs used in this study. (XLSX 10 kb)
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Turnbull, A., Ioannidis, S., Krajewski, W. et al. Molecular basis of USP7 inhibition by selective small-molecule inhibitors. Nature 550, 481–486 (2017). https://doi.org/10.1038/nature24451
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Eric (3)Wenzel, Amy (3)Brodsky, Stanley L. (2) 95 more... [+] Cutler, Brian L. (2)Falender, Carol A. (2)Gelso, Charles J. (2)Gurung, Regan A. R. (2)Kennedy, Carrie H. (2)Knapp, Samuel J. (2)Matsumoto, David (2)Mikulincer, Mario (2)Reyna, Valerie F. (2)Shafranske, Edward P. (2)Shaver, Phillip R. (2)Zedeck, Sheldon (2)Ackerman, Phillip L. (1)Adams, Glenn (1)Adkins, Joyce A. (1)Adler, Amy B. (1)Albers, Craig A. (1)Alexander, James F. (1)Allan, Robert (1)Ameli, Rezvan (1)American Psychological Association (1)Antony, Martin M. (1)Arsenio, William F. (1)Artelt, Elise (1)Baker, Ellen K. (1)Benjamin, G. Andrew H. (1)Berger, Andrea (1)Bergin, Allen E. (1)Bernal, Guillermo (1)Bishop, Kristen (1)Bliese, Paul D. (1)Block, Andrew R. (1)Bohart, Arthur C. (1)Bongar, Bruce (1)Bourne, Lyle E. Jr. (1)Breiger, David (1)Brewer, Britton W. (1)Britt, Thomas W. (1)Browning, Scott (1)Buskist, William (1)Buss, Arnold H. (1)Butcher, James N. (1)Byrne, Zinta S. (1)Campbell, Lorne (1)Cardeña, Etzel (1)Carroll, David W. (1)Carver, Sharon M. (1)Castonguay, Louis G. (1)Castro, Carl Andrew (1)Chapman, Sandra B. (1)Chubb, Charles (1)Clinton, Amanda B. (1)Cloitre, Marylène (1)Cohen, Adam B. (1)Cok-Cottone, Catherine P. (1)Comas-Diaz, Lillian (1)Confrey, Jere (1)Cooper, Harris (1)Cordova, James V. (1)Corrigan, Patrick W. (1)Costello, Peter C. (1)Dearing, Ronda L. (1)Diamond, Gary M. (1)Diamond, Guy S. (1)Diamond, Martha O. (1)Dik, Bryan J. (1)Dobson, Keith S. (1)Doherty, William J. (1)Donnellan, M. Brent (1)Dosher, Barbara A. (1)Dougherty, Michael R. (1)Drossel, Claudia (1)Duncan, Barry L. (1)Dunifon, Rachel E. (1)Dunn, Dana S. (1)DuPaul, George J. (1)Durand, V. Mark (1)Eisenberger, Robert (1)Enright, Robert D. (1)Falicov, Celia J. (1)Feeney-Kettler, Kelly A. (1)Findley, Jessica D. (1)Fisher, Jeffrey (1)Fogler, Jason M. (1)Ford, J. Kevin (1)Foss, Donald J. (1)Frank-McNeil, Julia (1)Freedheim, Donald K. (1)Fretz, Bruce R. (1)Friedman, Matthew J. (1)García, Eugene E. (1)Geller, Shari M. (1)Gendolla, Guido H. E. (1)Gillath, Omri (1)Glover, Todd A. (1)Hide details Results 1–10 of 149 Previous 1 2 3 ... Next Relevance Title A-Z Title Z-A Newest First Oldest First Sort by: 1.The Insider's Guide to the Psychology Major: Everything You Need to Know About the Degree and ProfessionThis book provides an overview of the psychology major, subdisciplines within the field, graduate programs and the admissions process, career opportunities for all degree types, internships, and free resources for students.Book/Monograph (June 2010)2.How Motivation Affects Cardiovascular Response: Mechanisms and ApplicationsThis book conveys the amount and diversity of motivationally based cardiovascular response research that currently is being conducted.Book/Monograph (September 2011)3.Perceived Organizational Support: Fostering Enthusiastic and Productive EmployeesUsing organizational support theory and evidence gathered from hundreds of studies, this book demonstrates how perceived organizational support affects employees' well-being, the positivity of their orientation toward the organization and work, and behavioral outcomes favorable to the organization.Book/Monograph (February 2011)4.Undergraduate Writing in Psychology: Learning to Tell the Scientific Story, Revised EditionUpdated to comply with the 6th edition of the APA Publication Manual, this book takes undergraduate psychology students step-by-step through the process of writing papers. The book includes full-length student papers and other visual examples to illustrate key concepts.Book/Monograph (June 2012)5.Stepfamily Therapy: A 10-Step Clinical ApproachIn this book, clinicians Scott Browning and Elise Artelt combine successful interventions within an original theoretical framework for stepfamily therapy, envisioning the stepfamily as comprised of subsystems, a series of overlapping relationships between individuals.Book/Monograph (August 2011)6.Research for the Public Good: Applying the Methods of Translational Research to Improve Human Health and Well-BeingThis book provides models and examples of translational research in the social and behavioral sciences—that is, research that links the findings of social and behavioral studies with programs and policies that improve human health and well-being.Book/Monograph (May 2012)7.Inside the Session: What Really Happens in PsychotherapyThis book presents full transcripts of three entire psychotherapy sessions, enabling readers to see not just what went right, but where the therapist may have missed a crucial detail or may have intervened at the wrong moment.Book/Monograph (February 2011)8.Varieties of Anomalous Experience: Examining the Scientific Evidence, Second EditionThis book is a scientific investigation of experiences such as synesthesia, lucid dreaming, out-of-body experiences and auditory and visual hallucinations, anomalous healing, past-lives, near-death experiences, mystical experiences, and alien abductions.Book/Monograph (August 2013)9.The Best Within Us: Positive Psychology Perspectives on EudaimoniaEnriching our understanding of happiness and well-being, this book explores the ways in which the philosophic concept of eudaimonism is embodied in psychological theory and research. Contributors discuss optimal functioning in individuals and communities, emphasizing human strengths and the fulfillment of potentials.Book/Monograph (February 2013)10.Handbook of Psychotherapy and Religious Diversity, Second EditionThis book provides psychotherapists both background knowledge and clinical guidelines for working effectively and sensitively with clients from the major religious faiths in the United States.Book/Monograph (May 2014) Previous 1 2 3 ... Next Relevance Title A-Z Title Z-A Newest First Oldest First Sort by: ADVERTISEMENT Results 1–10 of 149 for "Book/Monograph"X related to "What does Psi Beta offer its members?"

domain: library


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I’ve heard so many people say that they’re thankful when rejection or challenge hits, but it takes months or years until they get that perspective.
“Getting hacked was the best thing for me. I’ve learned so much about security since then.”
“Getting fired was the best thing that ever happened to me. I started my own business and now I have the freedom to do what I want.”
“I’m so glad that girl dumped me. I would have been miserable with her, and I’m so much happier now.”
There has been a lot of talk about rejection, conflict, and trauma lately. Everyone I know is going through some kind of challenge requiring them to think differently about their life.
It can send us into emotion turmoil when our vision of what we want doesn’t line up with the reality of the situation. And yet, within the push for something else, there is also a bit of a pull.
Where is this change trying to take you? You may feel “pushed out” of the past. Can you focus on the pull from your future?
Does this push present as true obstacle? Or is it just making the journey a little more interesting? What story are you telling yourself (and others) about the challenges in your life?
I’ve always believed that in every “negative” there is a positive you could have never seen had you not gone through the rough stuff. Even the absolutely roughest stuff prepares you for the journey in ways you cannot see when you’re soaking in it.
And sometimes, the rough stuff shows up just so you re-affirm your commitment to where you are and where you’re going. Nothing makes us re-commit to our journey like someone saying you can’t do it.
“Oh yeah?” You might say, as you affirm that: “I’ll show them.”
Can you make it a game? You can both play with what the challenge means to you by reframing how you talk to yourself about it. You can also delve deep into your competitive spirit and imagine yourself proving the others wrong.
How can you continue to focus on the end goal and still enjoy the journey of getting there? Finding a way to make the journey fun, more interesting, more humorous always helps.
Do you still have your sense of humor? Because if you’re not here for the lulz, you’re missing out.
No matter what path we choose to honor, there will be conflict to negotiate. If we choose to avoid conflict with others, we will eventually breed a poisonous conflict within ourselves. Likewise, if we manage to attend to our inner lives, who we are will – sooner or later – create some discord with those who would rather have us be doing something else.”Mark Nepo, The Book of Awakening
Conflict is a part of life. So many of us avoid it, and that ends up creating even more conflict. You’ve got to find a way to get comfortable with conflict, adversity, and rejection. It’s a part of life, much like a landslide is a part of living in the mountains. If you’re in the mountains, you’ve set your goals to climb higher. That means you’re set out to change. And when the outside world is changing, just maybe it’s reorganizing itself to create bigger stepping stones to rise to new heights.
We’re all on our way to somewhere else, and we get to frame the journey. Don’t lose sight of where you’re going just because the journey wasn’t exactly what you thought it would be. Sometimes as chess pieces on the board of life, we can’t fully see the game.
I publish Zantastic weekly with actionable insights on growing your brand and business, while staying sane through the challenges. Get posts like these in your inbox.

domain: psychology


text:
February 27, 2018
The Ten Tenors - Wish You Were Here
Phone: (520) 547-3040
Event By: Fox Tucson Theatre
Celebrated for their colourful repertoire, breathtaking arrangements and powerful live performances, The TEN Tenors Wish You Were Here concert is a tribute to musical legends lost before their time, featuring David Bowie, Leonard Cohen, Prince, Amy Winehouse, John Lennon, Michael Jackson, Freddie Mercury, Whitney Houston, and more. An evening with The TEN Tenors is guaranteed to surprise and delight in equal measure, at Fox Tucson Theatre.

domain: entertainment


text:
Prioritizing collective responsibilities in the response to COVID-19
Just as the success of the climate youth movement has been attributed to the clarity and consistency of messaging, we need this same strategy with COVID-19. We also need that clarity as we move beyond the current pandemic and address ongoing societal challenges, using it as a transformative force to move forward as a global community.
The cost of this pandemic must not bankrupt the people
The crisis has truly shaken the system. There is no doubt about that. A consequence of the failure of the austerity politics is that ideas that had been unthinkable just a few months ago – such as nationalization of hospitals and provision of substantial income support to unemployed workers – is on the agenda. We hope that this conversation develops into a popular global movement for a total reconstruction of the system.
Government inaction on COVID-19 threatens inmates’ lives
The government’s inaction reflects a deeply rooted attachment to risk-based, reactive paradigms when proactive initiatives that are precautionary and based on harm-avoidance are needed. The Liberal government is ignoring the reality that the virus does not discriminate, that prisons are porous to it, and that protecting the right to live is what defines us as human beings.
The pandemic’s unflattering glare: How the crisis is affecting care workers and prisoners
Multiple and concurrent disasters are unfolding in pockets all across North America connected to the spread of the COVID-19 pandemic. We understand this particularly in medical settings or in geographic contexts such as the hot spots in Seattle and New York City. But we will also witness disaster in institutional contexts, where a human tragedy is unfolding.
The false hope of a pandemic basic income
While we must embrace the most robust demands to win greatly improved and fully accessible income support systems in these harsh times, we don’t want inadequate solutions that extend a peace offering to the neoliberal order. We need radical alternatives and bold plans of action. The concept of a basic income fell short before this searing crisis and it has even less to offer us in the face of it.
Liberals’ COVID-19 support measures reveal crisis in Canada’s low-wage job market
Inequality and class disparity have been on full display in the devastating coronavirus outbreak. On the one hand, Canada’s dependence on the work of undervalued and underpaid health care workers, cleaners and retail employees has been clearer than ever. On the other, these workers are bearing the brunt of the economic crisis. In March, one-third of workers earning $14 an hour or less became jobless or lost most of their hours of work.
COVID-19 and the failures of capitalism
In short, capitalism had built up vulnerabilities to another crash that any number of possible triggers could unleash. The trigger this time was not the dot-com meltdown of 2000 or the sub-prime meltdown of 2008-9; it was a virus. And of course, mainstream ideology requires focusing on the trigger, not the vulnerability.
COVID-19 is a turning point for global power
The shifts occurring as a result of the COVID-19 pandemic are historic and volatile. While the eventual depth and duration of the twin health and economic crises are still unknown, there is no doubt that global powers are again using the shock of a crisis to consolidate power and vie for global leadership.
After the pandemic
When people emerge from their homes after the first wave of the COVID-19 pandemic they will be confronted by a greatly changed global order. A devastating public health crisis will continue to play out and a global economic slump that the pandemic has hastened and massively exacerbated will cast its shadow over the next several years.
The world rediscovers Cuban medical internationalism
This moment calls for global cooperation and solidarity, and on that front, Cuba provides a lesson for us all. We can start by demanding an end to US sanctions that stop Cuba from getting access to the resources it needs to fight this deadly pandemic, both for their own population and for the global beneficiaries of Cuban medical internationalism.
Page 17 of 19

domain: news


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18F-FDG PET/CT used for the diagnosis of polymyalgia rheumatica in patients of fever of unknown origin/inflammatory of unknown origin
In this study, we retrospectively analyzed data of a group FUO/IUO patients that suspected of PMR, aiming to analyze the imaging features of PMR in FDG PET/CT and evaluate the clinical value of FDG PET/CT in differential diagnosis of PMR. Materials and Methods: From January 2014 to June 2018, among the patients who underwent PET/CT examination because of FUO/IUO, 26 patients were suspected of PMR due to shoulder joint pain and stiffness, increased serum inflammatory factors and age over 50 years old. Clinical and imaging data of these 26 patients were retrospectively analyzed. Final diagnoses were made by board-certified rheumatologists. All patients underwent whole-body PET/CT acquisition from head to knee in the supine position with the arms next to the body.PET/CT images were interpreted visually, and the site of abnormal FDG uptake was recorded. Image characteristics of PMR were analyzed and image diagnostic criteria were proposed. According to the final clinical diagnosis, the diagnostic significance of PET/CT image diagnostic criteria and ACR 2012 classification criteria was compared. Results: Among the 26 patients, 10 cases were finally diagnosed as PMR. The remaining 16 cases were all connective tissue disease, including rheumatoid arthritis (5), dermatomyositis (3), ANCA-associated vasculitis (3), polyarteritis nodosa (2), RS3PE syndrome (1), relapsing polychondritis (1) and systemic panniculitis (1). FDG PET/CT imaging showed positive findings in all 26 patients. In...
We describe the most highly recommended generic and disease-specific PRO tools in SCD and discuss the challenges of incorporating them in clinical practice. EXPERT OPINION: PRO measures are essential to incorporate into SCD clinical trials either as primary or secondary outcomes. The use of PRO measures in SCD facilitates a patient-centered approach, which is likely to lead to improved outcomes. Significant challenges remain in adapting PRO tools to routine clinical use and in developing countries. PMID: 33034214 [PubMed - as supplied by publisher]
Publication date: Available online 10 October 2020Source: Meta GeneAuthor(s): Mansour Zamanpoor, Hamid Ghaedi, Mir Davood Omrani
Currently in fellowship doing bread/butter procedures (MBB, epidurals, PNB, few SCS/PNS trials, etc.) and just interviewed at a private practice spot where they do a lot of procedures that I will have not done any training in prior to graduating (e.g. IT pump, SI fusion, Vertiflex, Kypho, MILD, Discectomy, lots of SCS/PNS trials etc) and significant amount of "OR pain procedures" at a very busy practice seeing 30-40 pts/day - how many of you are commonly performing these procedures and are... private practice concern
Publication date: October 2020Source: Brain, Behavior, and Immunity, Volume 89Author(s): Fernando Lopes, Fernando A. Vicentini, Nina L. Cluny, Alexander J. Mathews, Benjamin H. Lee, Wagdi A. Almishri, Lateece Griffin, William Gonçalves, Vanessa Pinho, Derek M. McKay, Simon A. Hirota, Mark G. Swain, Quentin J. Pittman, Keith A. Sharkey
BEST supplements to relieve joint pain: Is your arthritis playing up? The wetter and colder months could partially be to blame. These two pills may help.
Authors: Kim H, Lim YM, Lee EJ, Kim HW, Ahn HS, Kim KK PMID: 33029979 [PubMed]
CONCLUSIONS: More than half of the iIONP patients had an enhanced oculomotor nerve in MRI. A few of them also had elevated CSF IgG synthesis rate, but no further evidence for inflammation was found. The administration of steroids seemed to have no benefit other than increasing the blood glucose level. PMID: 33029972 [PubMed]
Publication date: Available online 10 October 2020Source: Journal of Acupuncture and Meridian StudiesAuthor(s): Natália Freire Valente, Eliezer de Sousa Cardoso, Juliana Alencar da Silva Resende, Jeferson Antônio Santos
CONCLUSION: When gastroenterologists encounter NAFLD/NASH patients, serum CK should be verified. If hyperCKemia, frontal baldness, a hatched face, history of cataract surgery, and grip myotonia are noted, the possibility of MD may be considered. PMID: 33033573 [PubMed]
Authors: Kim MS, Moon JS, Kim MJ, Seong MW, Park SS, Ko JS Abstract Hereditary fructose intolerance (HFI) is an autosomal recessive disorder caused by a mutation in the aldolase B gene. HFI patients exhibit nausea, vomiting, abdominal pain, hypoglycemia, and elevated liver enzymes after dietary fructose exposure. Chronic exposure might lead to failure to thrive, liver failure, renal failure, and, eventually, death. HFI usually manifests in infants when they are being weaned off of breastmilk. Because HFI has an excellent prognosis when patients maintain a strict restrictive diet, some patients remain undiagnosed du...


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City of Ghosts Is a Perfect October Ghost Story
In October I often get in the mood for a ghost story. City of Ghosts fit the bill for me as a spooky middle grade fiction book by Victoria Schwab. It is the story of Cassidy Blake who as the ability to see ghosts and to visit the realm of spirits.
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