text:
Every weekday morning, white-haired women patiently line up before a door at a Dresden retirement home, step in and quickly step back nearly six decades into their past in Communist East Germany.
Most of the women—in their late 70s at the youngest—are suffering from severe dementia, but the reminders from bygone days trigger memories and skills once thought lost, and produce surprising levels of happiness and comfort.
They park their walkers next to a Kaufhalle sign from the former East German grocery chain, put on their colorfully patterned nylon aprons and start the day just like they did some 50 years ago. They chop up bell peppers, tomatoes and sausages for the popular Hungarian salad of their youth, wash dishes in an original 1960s metal sink and iron their laundry with old-fashioned pressing irons.
It's hard to imagine that many were—not so long ago—bedridden and unable to eat or use the bathroom on their own, Gunter Wolfram, director of the Alexa seniors facility in Dresden, told the Associated Press.
Wolfram said it was coincidence that he found out that Communist kitsch and other memorabilia brought comfort to some of his 130 residents. Two years ago he decided to decorate the home's movie theater with a vintage flashy Troll scooter that was once very popular in East Germany.
"Instead of paying attention to the movie, these people got so excited about the motorcycle. They could all of a sudden remember how to start the ignition, and chatted with bright eyes about outings to the Baltic Sea on their own Trolls a long time ago—it was amazing," Wolfram said.
So he set out to create an entire room in 1960s East German style, scouring the region's flea markets. Soon the demand for the daily trip back into the past had become so popular that Wolfram added a second room, this one designed in East German 1970s style—including psychedelic-patterned curtains and tasseled floor lamps.


text:
(2011). Evaluation of implanted gold seeds for breast radiotherapy planning and on treatment verification: a feasibility study on behalf of the IMPORT trialists. Radiother oncol,
BACKGROUND AND PURPOSE: We describe a feasibility study testing the use of gold seeds for the identification of post-operative tumour bed after breast conservation surgery (BCS). MATERIALS AND METHODS: Fifty-three patients undergoing BCS for invasive cancer were recruited. Successful use was defined as all six seeds correctly positioned around the tumour bed during BCS, unique identification of all implanted seeds on CT planning scan and ≥ 3 seeds uniquely identified at verification to give couch displacement co-ordinates in 10/15 fractions. Planning target volume (PTV) margin size for four correction strategies were calculated from these data. Variability in tumour bed contouring was investigated with five radiation oncologists outlining five CT datasets. RESULTS: Success in inserting gold seeds, identifying them at CT planning and using them for on-treatment verification was recorded in 45/51 (88%), 37/38 (97%) and 42/43 (98%) of patients, respectively. The clinicians unfamiliar with CT breast planning consistently contoured larger volumes than those already trained. Margin size ranged from 10.1 to 1.4mm depending on correction strategy. CONCLUSION: It is feasible to implant tumour bed gold seeds during BCS. Whilst taking longer to insert than surgical clips, they have the advantage of visibility for outlining and verification regardless of the ionising radiation beam quality. Appropriate correction strategies enable margins of the order of 5mm as required by the IMPORT trials however, tackling clinician variability in contouring is important..
(2010). Speckle tracking in a phantom and feature-based tracking in liver in the presence of respiratory motion using 4D ultrasound. Phys med biol,
We have evaluated a 4D ultrasound-based motion tracking system developed for tracking of abdominal organs during therapy. Tracking accuracy and precision were determined using a tissue-mimicking phantom, by comparing tracked motion with known 3D sinusoidal motion. The feasibility of tracking 3D liver motion in vivo was evaluated by acquiring 4D ultrasound data from four healthy volunteers. For two of these volunteers, data were also acquired whilst simultaneously measuring breath flow using a spirometer. Hepatic blood vessels, tracked off-line using manual tracking, were used as a reference to assess, in vivo, two types of automated tracking algorithm: incremental (from one volume to the next) and non-incremental (from the first volume to each subsequent volume). For phantom-based experiments, accuracy and precision (RMS error and SD) were found to be 0.78 mm and 0.54 mm, respectively. For in vivo measurements, mean absolute distance and standard deviation of the difference between automatically and manually tracked displacements were less than 1.7 mm and 1 mm respectively in all directions (left-right, anterior-posterior and superior-inferior). In vivo non-incremental tracking gave the best agreement. In both phantom and in vivo experiments, tracking performance was poorest for the elevational component of 3D motion. Good agreement between automatically and manually tracked displacements indicates that 4D ultrasound-based motion tracking has potential for image guidance applications in therapy..
IMPORT Trial Management Group,
(2009). Characterization of target volume changes during breast radiotherapy using implanted fiducial markers and portal imaging. Int j radiat oncol biol phys,
PURPOSE: To determine target volume changes by using volume and shape analysis for patients receiving radiotherapy after breast conservation surgery and to compare different methods of automatically identifying changes in target volume, position, size, and shape during radiotherapy for use in adaptive radiotherapy. METHODS AND MATERIALS: Eleven patients undergoing whole breast radiotherapy had fiducial markers sutured into the excision cavity at the time of surgery. Patients underwent imaging using computed tomography (for planning and at the end of treatment) and during treatment by using portal imaging. A marker volume (MV) was defined by using the measured marker positions. Changes in both individual marker positions and MVs were identified manually and using six automated similarity indices. Comparison of the two types of analysis (manual and automated) was undertaken to establish whether similarity indices can be used to automatically detect changes in target volumes. RESULTS: Manual analysis showed that 3 patients had significant MV reduction. This analysis also showed significant changes between planning computed tomography and the start of treatment for 9 patients, including single and multiple marker movement, deformation (shape change), and rotation. Four of the six similarity indices were shown to be sensitive to the observed changes. CONCLUSIONS: Significant changes in size, shape, and position occur to the fiducial marker-defined volume. Four similarity indices can be used to identify these changes, and a protocol for their use in adaptive radiotherapy is suggested..
(2008). A comparison of the use of bony anatomy and internal markers for offline verification and an evaluation of the potential benefit of online and offline verification protocols for prostate radiotherapy. Int j radiat oncol biol phys,
PURPOSE: To evaluate the utility of intraprostatic markers in the treatment verification of prostate cancer radiotherapy. Specific aims were: to compare the effectiveness of offline correction protocols, either using gold markers or bony anatomy; to estimate the potential benefit of online correction protocol's using gold markers; to determine the presence and effect of intrafraction motion. METHODS AND MATERIALS: Thirty patients with three gold markers inserted had pretreatment and posttreatment images acquired and were treated using an offline correction protocol and gold markers. Retrospectively, an offline protocol was applied using bony anatomy and an online protocol using gold markers. RESULTS: The systematic errors were reduced from 1.3, 1.9, and 2.5 mm to 1.1, 1.1, and 1.5 mm in the right-left (RL), superoinferior (SI), and anteroposterior (AP) directions, respectively, using the offline correction protocol and gold markers instead of bony anatomy. The subsequent decrease in margins was 1.7, 3.3, and 4 mm in the RL, SI, and AP directions, respectively. An offline correction protocol combined with an online correction protocol in the first four fractions reduced random errors further to 0.9, 1.1, and 1.0 mm in the RL, SI, and AP directions, respectively. A daily online protocol reduced all errors to <1 mm. Intrafraction motion had greater impact on the effectiveness of the online protocol than the offline protocols. CONCLUSIONS: An offline protocol using gold markers is effective in reducing the systematic error. The value of online protocols is reduced by intrafraction motion..

domain: literature


text:
Monday, Oct. 3 — Kick off Breast Cancer
Awareness Month by supporting patients in your community.
annual “It’s a Breast Thing” event takes place Tuesday to support local people undergoing the diagnosis, treatment and survivorship of breast cancer. Roughly
230,000 new invasive diagnoses are expected throughout 2011, as well as nearly
40,000 deaths, according to the American Cancer Society.
Stop by and vote in the
popular bra decorating contest: Thirty bras have been submitted by individuals and
local businesses under this year’s fairy-tale theme, and the top 12 will be
featured in the organization’s calendar featuring photos of local survivors. Submissions
may be purchased at the event for $30 each. The event is free, but donations
and proceeds will go toward the It’s a Breast Thing Non-Profit Corp., which
helps patients in Ingham, Eaton, Clinton and Shiawassee counties with
out-of-pocket expenses. The fundraiser will also feature a program about
hormones, exercise and cancer awareness.
'It’s a Breast Thing'
5 p.m. Tuesday, Oct. 4
Eagle Eye Golf Club
15500 Chandler Rd., Bath

domain: medical


Democratic leaders say state Sens. Paul Doyle, Joan Hartley and Gayle Slossberg betrayed their party's core principles when they sided with Republicans during last week's key budget vote.
But Glen Todaro, an unaffiliated voter from Rocky Hill and a constituent of Doyle's, has nothing but praise for the independent-minded trio.
"We've got to get bipartisan in the state of Connecticut,'' said Todaro, a 69-year-old veteran and former police officer who works part time in the aerospace industry. "It's been totally Democratic for the longest time. We need to make changes. We as veterans didn't risk our lives for this kind of crap."
Todaro had just ordered...


In the Modern-day automotive world, How each of these differs from each other and which one to choose based on your specific needs, so with traffic getting worse and worse for the day in India most of us are opting for Automatic Transmissions Systems when we want to purchase a new car although these variants come at a premium than a manual transmission, so let’s try to see what are the various Automatic Transmissions Systems that are available in Indian cars today. Here is the list of Automatic Transmissions Systems:-
- Torque Converter or Conventional Automatic Transmission (AT)
- Automated Manual Transmission (AMT)
- Continuously Variable Transmission (CVT)
- Dual Clutch Transmission (DCT)
Torque Converter or Conventional Automatic Transmission (AT)
The conventional automatic transmission remains the most popular most common form of automatic transmissions globally torque converters have been around for a long time now. The gearbox torque converters are made up of three main components
These three components lock and unlock with the help of multiple clutches and maintain predetermined gear ratios.
however conventional ATS can sometimes take away a fair bit of power resulting in power losses in the drivetrain and provides poor fuel economy compared to regular manual transmission the positives of a conventional automatic transmission are smooth gearshifts and reliability in terms of negatives fuel efficiency is lower compared to other types of gearboxes.
Automated Manual Transmission (AMT)
Automated Manual Transmission is one of the simplest implementations of an AT and is also the most cost effective, however with advancement in technology the AMT gearbox has made a comeback in emerging markets like India the AMT is a regular manual gearbox but with the addition of an electro-hydraulic system.
Which comprises of an electronic control unit and a hydraulic system this system which is also known as the Transmission Control Unit TCU. AMTs also offer a manual shift mode where the driver can change gears by using then gear shifter without having to use clutch due to the cost effectiveness it is mostly found in budget cars like the Maruti Suzuki Wagoner, Renault kwid and so on.
We can see that AMTs are the most cost effective transmission compared to its counterparts AMTs are also known to deliver high fuel efficiency something at the level of manual transmissions in terms of downsides AMTs are known to have slower gear shifts and they are also not smooth and produce a gear shift sound that you often hear in manual transmission moving on.
Continuously Variable Transmission (CVT)
CVT a Continuously Variable Transmission CVT s are one of the most defined automatic transmissions the CVT is use steel pulleys and the belt that can generate infinite Q ratios this means that there really are no gear changes are such leading to smooth seamless power delivery this type of transmission is very quiet – and is widely used in scooters in India.
However CVTs can feel a bit elastic when you drive them especially when you notice what is called a rubber band effect premium cars like the Hyundai i20, Maruti Baleno use these types of transmissions CVT can also get paddle shifters to give them a sporty appeal in India Honda cars like the Jazz City and civic offer paddle shifters with a CVT.
The best fuel economy among all automatic transmissions they also have smooth operation in stops at traffic situations in terms of cons Seabury suffer from a rubber band effect when Hard are also known to have slow acceleration
Dual Clutch Transmission (DCT)
A Dual Clutch Transmission or DCT uses two separate shafts with their own clutches for gear shifts one shaft for odd-numbered gears and the other one for even-numbered gears this type of automatic transmission provides quick shifts and delivers good fuel efficiency.
However, since the technology involved in a system is fairly complex and consists of a number of electronic components the costs associated with manufacturing a DCT.
It is relatively higher which is also the main reason for its lower level of adoption maintenance costs are another area of concern for these cities cars like the Volkswagen Polo, Amiyo, Skoda Rapid, Skoda Octavia are all available with dual-clutch transmissions.
Think to note Volkswagen has its own variant of the DCT, which it calls the DSG or direct shift gearbox in terms of positives these cities are known to have lightning-quick upshifts and downshifts they also have great performance.
Fuel efficiency but in terms of negatives these cities have higher manufacturing and maintenance costs and they are heavier than other transmission options so which one should you choose given an option well if you’re looking for a low-cost gearbox.
Also, cheap to maintain you will go for an AMT fuel efficiency on a MTS are at par with the manual counterparts and is yet another reason why you may go for an AMD that said if you’re looking for the best possible fuel efficiency then the CVT has got to be a pig not many manufacturers offer a CVT these days so that could be a concern.
When you’re looking for an ex car and if performance is of utmost importance to you then you’ve got to choose a DCT transmission model these cities are quick to shift and have minimal to no loss in power and torque and do not compromise on fuel efficiency.
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text:
WATERTOWN, N.Y. (WWTI) — Schools are down to their last milk cartons.
This is due to a national paper carton shortage which has hit the milk supply chain.
A memorandum was issued to schools across the country in the last week of October, and schools in Watertown have already been hit.
Students in the district are offered a carton of 1% milk or chocolate milk with each meal.
“They’re thinking that we’re going to have cartons through possibly this Friday,” Watertown City School District Food Service Director Mary Hughes said.
Beginning Monday, November 6, the District will no longer serve milk cartons at breakfast and lunch. Instead, milk will be served in plastic cups with lids and straws.
Watertown has over 4,000 students spread across eight school buildings. Hughes said this will come with many challenges.
“Some of the elementary schools only have one food service worker at the school,” she explained. “So it’ll be her job to not only cook the food and get everything set up, serve the stuff and then turn around and run the child through the computer, plus pour them a cup of milk.”
Milk products will also only be served during the breakfast periods. The District has opted for other beverages for lunch meals.
“For those elementary students, we’re going to be trying to get juice boxes so we’re not as concerned about spillage,” Hughes said. “At the High School and Case Middle School, we will be using some fruitable water dispensers so that there’s always something available for the students to have to drink.”
It will be a while before this problem is fixed. Schools have been warned that the paper carton shortage is expected to last through February 2024.
New York Dairy Producers issued the following statement on November 1 regarding the shortage.
“Dairy processors are working diligently with industry partners to find alternative solutions for serving fresh nutritious milk in schools as well as other institutions like hospitals, nursing homes, and prisons including pouring milk from gallon jugs as well as exploring the possibility of installing milk dispensers. We encourage school food service directors to contact their dairy distributors to strategize a milk delivery system that works best for their district until this packaging issue is resolved.”New York Dairy Producers
But Hughes said Watertown is ready.
“We’ll take it as it comes. The school is going to do the best they can and they’re going to make sure that the kids get a healthy breakfast and a healthy lunch no matter what,” she expressed.
So for now, say goodbye to milk cartons.

domain: food


text:
Riley Stone. Yep- it’s official. Protect Her: Part One is available now in audiobook form.
I was so lucky to have the opportunity to work with two very talented vocal producers for the production of the audiobook: Angel Clark read the part of Paige, and Robert Neil DeVoe read the part of Riley. So as a listener, you get to experience two unique voices- just like book itself.
When I held the auditions, I landed on Angel pretty quickly. She had a fun, edgy energy that I knew was characteristic of Paige. I gave her the direction of framing Paige’s character up like Buffy in Seasons 6-7. She’s a little cynical and jaded (okay, maybe a lot) because life had been cruel even though she’s still very young. But Paige is a fighter- of course, we get to see her fight (and just how tough she can be!) in later installments.
It was really important to me though to nail Riley’s voice. The voice had to be young (Riley’s only 28) but with a cocky and self-assured tone to it. Riley is unapologetic, irreverent (hence his love of cursing), and focused on his job. When he meets Paige in Part One, it really does rock him to his core. He’s not used to giving a crap about anyone. Then this strange woman comes along, and he drops everything- even though he doesn’t understand why. He just can’t let her go. His character arc has been a true delight to write.
Here’s a little audio sample to whet your appetite. Then I hope you’ll wander over to one of the retailers that I list below and buy the whole thing. It’s almost 2-1/2 hours of Riley and Paige for just a little bit more than the cost of a cup of gourmet coffee- IMO, well worth the investment. 🙂
Buy the Protect Her: Part One audiobook on Amazon.
Buy the Protect Her: Part One audio book on Audible.
Buy the Protect Her: Part One audiobook on iTunes.


text:
The Cube Escape [Minigame map]
The Cube Escape map for Minecraft PE is amazing minigame map, where you have to do 9 levels to go out from cube. Battle for your live and try to escape from strange cube. On your way will be difficult parkour, maze and other interesting challenges. Are you ready? Because we start just now!
Here you can look at more screenshots of this map
As you can see this map made not for one or two days. I recommend just to see how amazing it was planed and realize.
we recommend to download this map for Minecraft Pocket Edition 1.2 +

domain: game


text:
Personalized Thank You Cards by Petite Lemon Prints
Say "Thank You" with a modern, personalized thank you card. Make it yours by personalizing it with your name or charming photo. From monograms and classic fonts to beautiful patterns and bright colors, you’ll find a dazzling array of darling and thoughtful designs. If you are looking for other personalized products be sure to browse our selection of personalized gifts and baby keepsakes including 1st birthday shirts, personalized growth charts, alphabet posters, personalized baby onesies, personalized birthday shirts, personalized tshirts for kids and our darling big sister tshirt and big brother tshirt line.

domain: design


Our company has 40 years of mining machinery manufacturing history !
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Steel slag i ntroduction. The steel slag crushing production line is a production line for recycling and recycling of steel slag and other resources based on the characteristics of steel slag hardness and rationally equipped equipment.Dewo provides customers with technical services and design of 30-800tph steel slag processing line
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text:
Keith Mitchell (UGA Golf 2011-2014) had won $99,163 on the Web.com tour (24 starts) and $44,295 on the PGA’s Tour Latinoamerica before his tie for 11th in the Valspar Championship. Sunday he collected $144,900 for his efforts on Innisbrook Resort’s Copperhead course.
Mitchell had and eagle on his first hole…
— PGA TOUR (@PGATOUR) March 10, 2017
…and a 47-foot birdie on the 72nd
It’s going to help me a lot the rest of the year knowing if I can compete out here, I can definitely compete on the Web (Web.com Tour) and just try to earn playing out here next year, Mitchell said. That’s the goal this year. And after my good play this week it will really help me with that comfort level and confidence.
Playing on the Web I’ve struggled sometimes on weekends. Been close to the lead and haven’t closed out. Learning from those experiences on that Tour really helped me this week. I knew I was playing well. I just had to finish the 18 holes solid and not get in the way, Mitchell said.
When asked about the number of former Bulldogs on tour, Mitchell respond to Hummer:
Man, I’ve got some big shoes to fill with those Georgia guys, he said. They’ve been so awesome to me, helping me prepare and do the things I needed to do to get here. They’ve got a lot of wins and I’ve got zero. I’ve got some work to do to catch those guys.

domain: sports


text:
How to: grow your own mushrooms
Explore options for growing your own fresh mushrooms at home
Watch the wonders of nature as your mint grows into a new plant before your eyes
Are you one of those people who feels like they kill every plant they lay their eyes on. Be reassured that everyone can garden with a few key pointers.
5 ideas for simple salad greens you can grow yourself
Grow edible plants like herbs, root vegetables, and fruit in containers. It's perfect for small-space gardeners!
Traditional Japanese boro cloths have a beauty like no other. Each cloth tells a unique story of its journey through life with patches carefully sewed on and reinforced with stitching, often over generations of a single family.
Learn how you can grow your very own supply of ginger with these tips and tricks

domain: agronomy


text:
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domain: entertainment


Originally launched in 2002, XBMC launched first as Xbox Media Player (for the original Xbox console), followed by Xbox Media Center and finally XMBC. Despite its roots, the software has never been officially launched for the Xbox 360 nor the Xbox One, making its name quite silly and confusing.
So why the change finally? Reads the blog post: "Six years have passed since the Xbox Media Center became XBMC, and simply put, "XBMC" fits less now than it did even in 2008. The software only barely runs on the original Xbox, and then only because some clever developers are still hacking on that platform. It has never run on the Xbox 360 or Xbox One.
Furthermore, while the software still acts as a media center, it also hosts addons, loads games, streams content to and from numerous devices, and can ultimately act as a complete replacement for whatever platform it is hosted on. Indeed, XBMC today is far more an Entertainment Center than a simple Media Center.
In essence both the "XB" and "MC" simply don't make a whole lot of sense any more."
Additionally, since the team (XBMC Foundation) chose to start the software with Xbox in the name (trademark Microsoft), they have never had any legal control over its use, leading to a plethora of other issues including scammers selling the open-source software in different iterations.
Luckily for fans of XBMC, Kodi will be little more than a name change, keeping the same underlying software and licensing under the GPL 2.0.
Written by: Andre Yoskowitz @ 4 Aug 2014 20:46


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9 March, 2019
March 9 is National Meatball Day!Jump to Recipe
Please rate my recipe at bottom of this page.
Hunting is a part of my family's life and life in Wyoming. We keep a freezer full of game meat to feed us all year long. My husband and son love antelope, I could take it or leave it. It is a little strong for my liking so I'm always looking for ways to fix it so I can enjoy dinner too.
This was sort of an accidental success. We thawed antelope burger for dinner and had a package of thawed pork sausage that didn't get eaten over the weekend. I looked at several meatball recipes for basic ideas and added my own style. Smoking it on the outdoor grill was key, antelope meatballs that I even loved.
We serve these on pasta with spaghetti sauce but they taste awesome on their own, in a meatball sub, and would even be great in a meatball slider. Try smoking them in advance of a camping trip and finish them off on the campfire.
In years past I used my hand to mix meatloaf, meatballs, ect. This time I used my Pampered Chef Mix 'n Chop... and I'm never going back! it did a through job combining the ingredients and I didn't get my hands icky.
- Treager Smoker
- Manual Food Processor
- Microplane® Adjustable Fine Grater
- Large bowl
- Garlic press
- Mix 'n Chop
- Large Scoop (1.5 oz)
- RockCrok Grill stone
- 1 LB Ground Antelope
- 1 LB Pork Sausage
- ½ Cup Parmesan Cheese Freshly Grated
- 3 Cloves Garlic Pressed
- 1 Medium Onion OR - 1 TBSP Onion Powder
Baking and Spices
- 1½ TBSP Pampered Chef Italian Seasoning Mix Item Number: 9719
- 2 TSP Ground Pepper
- 1½ TSP Sea Salt
- 1 TBSP Dried Parsley Flakes Or ¼ cup fresh chopped
- ⅔ Cup Italian Bread Crumbs Or plain bread crumbs and increase the Italian herbs by ½ TBSP
- 2 TSP Worcestershire Sauce
- Chop the onion in the Manual Food Processor into small pieces.
- Grate the Parmesan Cheese
- Combine all ingredients in a large mixing bowl, using a garlic press to press garlic directly into the bowl.
- Mix well with the Mix 'N Chop.
- Scoop into 2" meatballs onto the RockCrok Grill Stone.
- Bring the Treager to smoing temurature, 160º, and smoke for 20 minutes.
- Turn treager up to 350° and cook until done through, about 20 minutes. Do not overcook, the meatballs will contunue to cook on the hot stone after you take them off the grill.


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text:
Hi, mah name is Anoushka (I like to call meh self Atari, don't ask me why) and I'm a fangirl...of a lot of things. PM me anytime I don't mind, I love making friends on wattpad (just realised how creepy that makes me look, meh.) My books are terrible but I hope you enjoy them anyway.
Some random stuff about me:
I love reading, you can recommend some books to me or we can fangirl over Legend, Harry Potter and maybe soon, Percy Jackson.
I like anime but I'm not one of those fans that has watched every anime in existence. I've watched Fairytail, Akatsuki no Yona (some of it), Re-Zero (some of this too), currently watching Toradora (hopefully imma finish it)
I like TV shows too like Superstore (OF WHICH I'VE WATCHED ALL 3 SEASONS), Big Bang Theory. I forgot the rest.
CHEESY QUOTES ARE AESTHETIC
- Why do you want to know?
- JoinedOctober 15, 2017

domain: hobby


text:
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Mass Index indicator for Trading - Tutorial and Examples
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On the other hand, if the volatility is low it can indicate that most likely we’re dealing with a false breakout and it’s better to fade the move.The Volatility MT4 indicator can be used by the short-term trader as well as by the long-term trader because no matter of your trading style, knowing if you’re trading in an environment with high volatility or low volatility can make the difference between success and failure.Going forward, you are going to learn a unique strategy using the Volatility MT4 indicator. Options trading no minimum deposit. Now let's look at one of the most widely used volatility indicators by professional traders. This is not a technical indicator, but an index that is.I am already aware of the ADX Average Directional Movement Index and the BWI Band Width, i.e. Bollinger Indicator and have tested those.For those of us trading forex expert advisors or trend following strategies, we may have. Investors look at various volatility indices due to following main reasons. ATR is a default indicator on the MT4 platform which appears as a single line.
Volatility Forex Trading - FXStreet
This will make sure that the market is really in a strong trend and only once the volatility is high enough, which ensures that we’re going to have enough profit margin to have a profitable trade.Volatility MT4 Indicator – Recommended Time Frames Technically speaking, you can use this MT4 indicator for all time frames.However, the shorter the time frame, you will see more fluctuation and possibly more whipsaw which may cause small losses that can eat up your portfolio quickly. Stockpair ipad app kostenlos. Name, Value, Action. CCI14, -103.3212, Sell. ATR14, 0.0006, Less Volatility. Highs/Lows14, -0.0006, Sell. Ultimate Oscillator, 46.833, Sell. ROC, -0.204.Our Forex movement chart provides an overview of recent price volatility for currency pairs & commodities - a simple measure of volatility for a selected currency.The VIX Volatility index indicator. In 1993, the Chicago Board Options Exchange CBOE introduced the VIX index to measure market expectations and.
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Volatility Variability What is Volatility in Forex - Trading Point
Forex Volatility Indicators Volatility indicators show the size and the magnitude of price fluctuations. In any market there are periods of high volatility high intensity and low volatility low intensity.EasyMarkets offers trading the USD Volatility index. Important Economic Indicators You Should Always Focus On · Education · Crispus Nyaga.Volatility-based indicators are valuable technical analysis tools that look at changes in market prices over a. EURUSD Range trading Forex as for 24/01/2020. Moving averages are probably the most common indicator used by forex traders and although it is a simple tool, it provides invaluable data.Simply put, moving averages measures the average movement of the market for an X amount of time, where X is whatever you want it to be.For example, if you applied a 20 SMA to a daily chart, it would show you the average movement for the past 20 days.
The indicator shows the volatility of a currency pair. This knowledge may be very helpful when using one strategy or another. - Free download of the.Using forex volatility indicators and volatility signals you can predict currency movements before its too late.Best Forex Trading System. Volatility Indicators. Volatility Indicators can be used to develop a bestforex trading system or trading strategies suitable for trading Stocks, Exchange Traded Funds, Forex, Commodities, Bonds, Futures, etc. The Relative Volatility Index Metatrader 5 forex indicator consists of two colored filled floating area’s which represent support and resistance. Setting the floating levels to 1 turns off this feature, something this indicator really needs.Find out why Forex Volatility Indicators are important, how they can help you to gauge the market, which volatility indicators are available, and more!Although it is originally a measure of the implied volatility of S&P 500 index options, it has been widely accepted by forex traders as a key indicator of investor.
Learn more about the "fear gauge" - the Volatility Index - calculation, trading. The Volatility Index VIX is widely considered the foremost indicator of stock. regulated Forex broker; Access to a free demo trading account with 0,00 in.Volume Indicators for MT4 & Volatility Indicators for MT4 Download over 500+ Forex & Trading books from Forex-Station's member's only Trader's Library. Latest postsAnother crucial volatility forex indicator — and arguably one of the oldest — is the moving average. In general, moving averages are lines drawn on charts to give the average price at a given point over a definite period of time such as minutes, hours, days, or weeks. Dt swiss m1700 spline 29 test. Last on the list is the Average True Range, also known as ATR.The ATR is an excellent tool for measuring volatility because it tells us the average trading range of the market for X amount of time, where X is whatever you want it to be.So if you set ATR to 20 on a daily chart, it would show you the average trading range for the past 20 days.
There are several volatility indicators available for stock traders and analysts to use when determining entry and exit points for trades. Volatility.Here are some of the best volatility indicators that can assist you in measuring the volatility of a currency pair. Overview of trading strategies ag.

domain: finance


text:
Special counsel Jack Smith’s office on Monday said that former President Donald Trump wants a “carnival atmosphere” at his March trial in the nation’s capital for accusations that his 2020 election challenges constitute “election interference.”
According to the legal response, Trump “may elect to craft court filings with the goal of gathering media coverage rather than lawful relief from the Court, as he appears to have done on this and many other occasions,” but there’s no reason to make an exception for the former president.
According to Smith, Trump desires “to create a carnival atmosphere from which he hopes to profit by distracting, like many fraud defendants try to do, from the charges against him.”
“As the Court has already observed in proceedings in the defendant’s criminal trial, the defendant and his counsel will, if permitted, design their in-court statements instead to wage a public relations campaign,” the Special Counsel’s office added.
Trump is currently confronted with a four-count indictment that was remanded in August. The charge is that he engaged in a conspiracy to “obstruct the government function responsible for collecting, tallying, and certifying the legitimate results of the 2020 presidential election through the use of knowingly false allegations of

domain: news


You Can Own A Tron Lightcycle
Not just a Tron Lightcycle, but one that runs and is street-legal. You’re just going to need around 35K to do so. But hey, if I had it I’d do it. How awesome would that be?
The bike will be custom built based on what you want including a choice between either a high-powered electric or gas-powered motor. Go here for the listing and more info


By Fiona, ASPIRE (Asian Students Promoting Immigrant Rights through Education) Member
In honor of National Coming Out Week: Undocumented and Unafraid we are featuring stories of API dreamers. The DREAM Act would provide undocumented students that arrived before the age of 16 in the US a pathway to legalization.
My name is Fiona and I am undocumented and unafraid.
In 2001, I came to this country with my father and sister from the Philippines. My mother had already been working here for over a year and was being petitioned by her employer to get a green card. Both my parents decided that it was unhealthy for my sister and me to grow up without the presence of our mother in our lives so we immigrated to the US with the intention of adjusting our status in a few years. Unfortunately, the law firm used by my mother’s company was found guilty of committing fraud and this dramatically affected our case.
Our application was pending for a long time. And through those years, my family underwent a lot of emotional challenges: my parents got divorced and our family was torn apart because of it. My mother eventually remarried. My step father was able to adjust my mom and my younger sister’s immigration status, except for mine. Because I was over the age of 18 I couldn’t adjust my status with the rest of my family. Now I am in deportation proceedings. I’ve had to stand in front of an immigration judge to defend my right to stay in this country I call home.
At first, my mother forbade me from talking about my status to anyone. I didn’t even tell my extended family or close friends for a long time. This made me feel like I was facing this problem alone. I became depressed and felt hopeless, until I heard about the federal DREAM Act. This piece of legislation would give children who came to this country before the age of 16 a pathway to legalization if they attended two years of college or served two years in the military. I closely followed the news surrounding the DREAM Act. Last September, I found out that there was a rally in my neighborhood in support of the bill. This was my first time going to a rally but it was good to meet so many other young people in my situation.
Now I am an active member of ASPIRE, the first Asian undocumented student group. Even though the federal DREAM Act did not pass last year, I am still grateful that I was introduced to this great group of people. They give me hope and together we work toward informing others of the injustice of this immigration system, promoting higher education for other undocumented students, and ultimately, a way to prevent deportation of other DREAM Act eligible students like myself. I want others to know that it’s okay to be undocumented, we shouldn’t be ashamed of a situation we had no control over. We should do something about it and join groups like ASPIRE, because together is the only way we’re going to get justice.


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There are times when I get home from work, drop my bag, open the fridge, and dinner just jumps out at me. I see the garlic scapes on the middle shelf, the tomatoes on the counter, some good ricotta lurking in the back, and it’s done: summer pasta.
But other times, despite what others surely would call a full fridge, I can’t seem to find anything to make. Last Wednesday was one of those times, and I’ll have you know that I came this close to running down the street and grabbing a rice bowl–before an idea popped into my head.
A couple weeks ago, friends had us over for a last-minute al fresco dinner. The plan was to fry up some of the squash blossoms that had bloomed in their garden; we figured the rest would come together. I brought a mondo salad and some fresh mozzarella to stuff in those squash blossoms. They pulled off some amazing Mexican elote-style corn and a bunch of other grilled things. But perhaps the star of the show – not to take away from the elote and the blossoms – was the appetizer, which they’d made with the help of Blue Apron.
If you don’t know it, Blue Apron is one of these start-up cooking services that sends you perfectly portioned amounts of everything you need to make dinner for two at home. The ingredients seem high-quality, the instructions are clear, and the recipes are pretty creative. I’ve spent quite a bit of time onÂ their website, and I’ve found about a dozen great ideas for easy, inexpensive dinners that you can make at home in about 30 minutes.
These pickles were an accompaniment to a Korean-style scallion pancake. We noshed on them while we finished getting dinner on the table, but I couldn’t stop thinking about them for days, so I finally looked up the recipeÂ and made them and the scallion pancake at home, rescuing my cash from the rice bowl place in the nick of time.
There is one ingredient in the pickles that you might not have lying around: black vinegar, also called Chinkiang vinegar. It’s mellow and a little bit malty; I love it in a tofu stir fry, and it’s perfect in these pickles. The one I have isÂ available for 7 bucks on Amazon, but if you can’t find it, you can substitute an equal amount of rice wine vinegar and if you have it, add a teaspoon or so of sorghum molasses for that smoky, malty flavor.
Perfect Asian Quick-Pickles
Adapted from Blue Apron
Makes enough for 4 as a snack
2 Kirby or Persian cucumbers, halved crosswise and cut lengthwise into quarters
4 radishes, cut into thick coins
1 garlic scape, coined (or substitute 1 scallion)
2 teaspoons sesame oil
1 tablespoon soy sauce
1 tablespoon Chinese black vinegar (or substitute an equal amount of rice vinegar with a teaspoon of molasses)
1 teaspoon Sambal Oelek, sriracha, or other hot chile sauce, to taste
Combine all ingredients except the vegetables in a medium bowl and whisk with a fork to combine. Taste, and adjust the quantities of chile, vinegar, and soy sauce as needed. Add vegetables, stir to coat with the marinade, and set aside for about 15 minutes before serving.


Russia’s Search Engine Yandex Steathily Moves West
Yandex now has deeper cash pockets following its IPO -- so where and in what type of expansion is the company going to expand? Moving west and south perhaps? There are good competitive reasons why Yandex needs to take its battle with Google to other markets -- but it also needs to be secure at home -- in Russia.
Fresh off its IPO, Yandex recently raised $1.3 billion, giving it a significant cash resource for investment in its own development and expansion. Now whilst Google continues to push for more share of the East, the team at Yandex has been both strengthening their position in Russia and slowly pushing their search engine in Google’s direction and towards the West by two different means.
Preston Carey, Yandex’s US-based Business Development Director, is a regular speaker at the International Search Summit workshops and provides regular updates on progress and he makes clear that Yandex is working to give greater access to advertisers from outside of Russia to home in on Yandex’s domestic markets. This means localizing both tools and people.
Yandex Releases Yandex.Webmaster – Its Webmaster Tools Solution
Additionally, this week Yandex announced the release of a key tool for international search markets, namely the opening of their Webmaster tools area to English users, pictured below.
This enables people working internationally to access data from Yandex including crawler issues, which pages are in Yandex’s index, who links in, searches, viruses and improving the appearance of your site in results.
This is a great help, but also has its limitations.
You still need a Russian language speaker to do the real work because keywords and anchor text still have to understood from a Russian perspective – but at least it will remove some of the fear that non-Russian speakers have of dealing with Russian projects. Typically, they feel more comfortable working with Google in Russia even despite its smaller market share.
I asked Yandex for data on how many people were using the tools, but unfortunately, they didn’t have this yet and pointed to a very positive reaction from the press as evidence of progress.
Protecting The Russian Heartlands
In Russia, Yandex’s own market share seems to be holding firm with actual searches on Yandex growing exponentially to 2.3 billion per month as the above chart shows.
Significantly, Yandex has firmed up its position at home by doing a deal with Rambler, now the smallest search engine contender having dropped from a strong second place and apparently becoming the biggest loser to Google. Yet, Rambler still has a search audience of 4.2 million and reaches 14% of the Russian Internet audience.
It’s a fairly complex arrangement whereby Rambler’s search services are powered by Yandex’s search engine and Rambler has also joined Yandex’s Ad Network. Ads placed via Yandex can now run in Rambler’s search results, as well as on its content pages.
Rambler was principally working with a company called Begun in which Rambler has a controlling interest so this agreement involves the sharing of inventory between the two systems.
Begun’s advertisers have been given an opportunity to run their ads in any placement position on Rambler, thanks to the Begun system placing their ads via Yandex. These ads can also run on Yandex’s search results pages and on the pages of websites in the Yandex Network. Got it?
Now More Local Search Suggestions
In March, Yandex improved its search suggestions to based them on the user’s location.
Now, the user in Moscow typing театр (theater) in Yandex’s search box will see the театр сатиры (Satire Theater) suggestion, while the search engine’s suggestion for the user in Kirov will be театр на спасской (theater on Spasskaya), and a theater enthusiast in Kaliningrad will be offered театр на бассейной калининград (theater on Basseynaya in Kaliningrad).
Currently, Yandex offers over 40 million search suggestions and these words appear on Yandex’s search page over 25 million times a day.
The Second Strand Of Yandex’s Westward Strategy
I said that there were two ways in which Yandex is moving westwards out of Russia and the second is that the company is beginning to talk about its progress in eastern Europe where it appears to be gaining share from Google.
These markets are used Cyrillic characters and are close to Russia — they represent the best way for Yandex to build its international standing. See the chart below.
Will Yandex really only target Cyrillic or Slavic countries in the future? My questions are always replied to with, “Sadly, we cannot comment on our plans regarding international expansion. The only thing we can say is that we constantly explore all kinds of opportunities”.
Which means, yes we’re going for it,but we don’t want to tell you where. If you look at linguistic, geographic proximity and economic factors, my money is on Turkey and the Middle East. We will see.
New on Search Engine Land


text:
The Ambassador in the United Kingdom (Winant) to the Secretary of State
[Received June 28—4:20 p.m.]
6519. Resulting from London press reports appearing at end of May to effect that three aircraft loads of German FonOff archives have been brought to England, Soviet Amb82 here has made demand to FonOff that Soviet investigators be granted access to examine these archives. FonOff states it made preliminary reply and promised to investigate matter. Sunday Chronicle of June 24 carried account of photographing and recording of secret documents by Air Ministry in London which clearly refers to microfilms obtained by joint Fon Off—State Dept CIOS team and copies of which have gone to Dept. FonOff states it is investigating source of leakage.[Page 1113]
Emb has now received letter from FonOff stating Soviet Amb is pressing for final answer on this matter, but in view of fact that United States has same rights and interests in these archives as Brit, FonOff wishes to obtain Dept’s agreement to its reply. Subject to Dept’s approval FonOff propose to begin reply by saying that press reports seen by Mr. Gousev regarding arrival in London of carloads of German FonOff documents are unfounded in as much as all original German FonOff documents which have been discovered by SHAEF forces are still in Germany among large mass of miscellaneous German archives located at different places under SHAEF control. FonOff would go on to say that it presumes German state archives of similar type and value have been located by Soviet forces in their area of occupation. Facilities for examination in each case doubtless depend on exigencies of military administration and progress of sorting on the spot. FonOff would then add that only relevant material which has reached London consists of certain microfilm copies which are being processed and sorted by a technical dept preparatory to thorough examination and, where worthwhile, translation. Soviet authorities have no doubt similarly taken copies of German archives in their possession as matter of routine. In view of early stage of work done on Brit side FonOff have not even taken initiative of proposing discussion between Allied powers on exchange of copies of documents under their control and in circumstances it would appear premature to send experts to London in order to take advantage of any reciprocal arrangement which may be made in due course.
FonOff letter to Emb adds that it hopes shortly to be approaching Dept with proposals on whole subject, but that in meantime it considers it necessary to send a reply to Soviet Emb and it would appreciate it if urgent consideration could be given by Dept to the terms as given above in which it proposes to draft reply. If Dept desires inclusion in FonOff reply of reference to fact that the documents in question are under joint United States–United Kingdom control FonOff states it would have no objection to amending its draft accordingly.
Dept’s views urgently requested.
- Fedor Tarasovich Gusev.↩


text:
The company has the support of the City |
The soccer Cartagena has launched a new initiative, the first School Modernization, where small five to twelve years old can improve their tactical and technical, with greater emphasis on the specific school of goalkeepers.
This modernization is a weekly hour class, taught on Saturdays from 12:00 to 14:00 hours (two shifts) in the indoor pavilion Urban UPCT.
With this, the team holds its line to reinforce the quarry.
A federated three teams at junior, cadet and children, is added, today, opening seven venues sports schools through the participation of schools in the city and co-operation of the Department of Sports City of Cartagena.
So far, FS Cartagena Schools are already present in: Garden City College, Marist, Gabriela Mistral, Narval, institute Los Molinos and Los Dolores, in addition to the installation of municipal flag Wssell Guimbarda, location of the seventh school.
Source: Ayuntamiento de Cartagena


text:
فلقد عَلِمْتُ بِأَنَّ عفوك أَعْظَمُ
إِنْ كَانَ لاَ يَرْجُوكَ إِلاَّ مُحْسِنٌ
فَمَن الذي يَدْعُو ويَرْجُو المجرم
أَدْعُوكَ رَبِّ كما أمرت تَضَرُّعاً
فَإِذَا رَدَدَّتَ يَدِي فمن ذا يَرْحَمُ
دُرُوب الــخـــيــر Telegram | DID YOU KNOW?
To pay the bills, Mr. Durov is issuing investors $1 billion to $1.5 billion of company debt, with the promise of discounted equity if the company eventually goes public, the people briefed on the plans said. He has also announced plans to start selling ads in public Telegram channels as soon as later this year, as well as offering other premium services for businesses and users.
At a time when the Indian stock market is peaking and has rallied immensely compared to global markets, there are companies that have not performed in the last 10 years. These are definitely a minor portion of the market considering there are hundreds of stocks that have turned multibagger since 2020. What went wrong with these stocks? Reasons vary from corporate governance, sectoral weakness, company specific and so on. But the more important question is, are these stocks worth buying?دُرُوب الــخـــيــر from DE
Deutschland DE telegram Group & telegram Channel 10
From: Deutschland and United KingdomTelegram دُرُوب الــخـــيــر🌱, 8181 Telegram Group & Telegram Channel Deutschland, DE
Telegram دُرُوب الــخـــيــر🌱, 8181 Telegram Group & Telegram Channel, United Kingdom, GB


Pope accepts resignation of Irish bishop, former papal secretary
March 24, 2010
Pope Benedict XVI has accepted the resignation of an Irish bishop whose handling of sex-abuse complaints drew intense criticism from public officials and from his fellow bishops.
Bishop John Magee of Cloyne tendered his resignation on March 9, apparently at the request of the Holy See. The Vatican announced on March 24 that the bishop's resignation had been accepted. Bishop Magee had come under fire late in 2008 when a report by the independent National Safeguarding Board for Children said that the Cloyne diocese had put children at risk by failing to confront clerical abusers.
Several Irish bishops, as well as government leaders, quickly began pressing for Bishop Magee's resignation. In March 2009, reacting to those requests, Pope Benedict removed Bishop Magee from active control of the Cloyne diocese and appointed an apostolic administrator, Bishop Dermot Clifford, to handle diocesan affairs.
Before his appointment to the Cloyne diocese, Bishop Magee had served at the Vatican, where he was a personal secretary to three Popes: Paul VI, John Paul I, and John Paul II.
For all current news, visit our News home page.
- Rinunce E Nomine (Holy See)
- Statement from Bishop John Magee on his resignation (Irish bishops' conference)
- Statement by Archbishop Clifford on the resignation of Bishop Magee (Irish bishops' conference
- Statement by Cardinal Seán Brady on the resignation of Bishop John Magee (Irish bishops' conference)
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Posted by: Don Vicente -
Mar. 24, 2010 10:50 PM ET USA
According to the Vatican website, the resignation is another Canon 401 section 2 resignation.


- Original Pdf: pdf
- Keywords: Informed Search, Deep Learning, Heuristics, Transfer Learning, Efference Theory
- TL;DR: We present a neuroscience-inspired method based on neural networks for latent space search
- Abstract: Planning in high-dimensional space remains a challenging problem, even with recent advances in algorithms and computational power. We are inspired by efference copy and sensory reafference theory from neuroscience. Our aim is to allow agents to form mental models of their environments for planning. The cerebellum is emulated with a two-stream, fully connected, predictor network. The network receives as inputs the efference as well as the features of the current state. Building on insights gained from knowledge distillation methods, we choose as our features the outputs of a pre-trained network, yielding a compressed representation of the current state. The representation is chosen such that it allows for fast search using classical graph search algorithms. We display the effectiveness of our approach on a viewpoint-matching task using a modified best-first search algorithm.


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Ever wondered how you can perform ROMs and Emulators with regards to PC within the net? Playing the overall game is one of the items that renders the game playing community what it is. It could no unique when you are discussing PC Roms with regards to Android and Emulators.
LAPTOP OR COMPUTER Roms or, a Personal Computer ROM is certainly the one which is for personal only use. PC games are generally highly revised and intensely hard to play. You might say they are such as an outlawed edition of playing a Nintendo Video game Young man game. If you were to want to experiment with the overall game with your pc then you should do a whole lot of explore to find out which usually adaptation in the ROMs with regards to PERSONAL COMPUTER meets your requirements.
Emulator for the purpose of Android on the other hand is the same as LAPTOP OR COMPUTER ROM to get Android although functions in a manner that emulates a certain kind of equipment. Game Fix as an illustration is the full of the Nintendo DS emulator using a quite high success rate. There are plenty of sites available for these kinds of video games on the net.
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Simulator meant for Android tend not to require you to have got a selected brand of components. They usually come with a range of two types of ROMs.
You must realize that several simulator to get Android have time and can be determined by simply looking for all of them on the search engines. These are generally as well the most used options, but not definitely the very best to fit.
The simple fact that many of simulator meant for Android have time does not mean they may be any a reduced amount of efficient or perhaps correct as many websites can assert. It is advisable to spend a bit of time and find the best emulators to suit your needs depending on match ups and features.
PC online games and emulators just for LAPTOP OR COMPUTER will be for the most part a lot more advanced than whatever you can usually get for that gaming system. Considering the growth of technology nevertheless , a lot of video games is also available to portable https://custom-roms.com/roms/apple-ii/karateka-1984-broderbund-a3-usa gadgets and simulator just for PC will be the samsung s8500 of the future.


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Not known Facts About Cheltenham DentistsThe implants can help reduce the confront from sinking in exactly where a tooth is missing and improve your bite when enamel might be shifting from location.
Most of the staff on the surgical procedures are welcoming, welcoming, and therefore are often accommodating . I anticipate my visits towards the dentist which is a thing I haven't expert until finally gonna Cheltenham Dental Spa.
The time taken for inserting dental implants will depend on the bone structure and needs of every individual patient.
As seasoned cosmetic dentists Arnica can give a whole range of cosmetic dental remedies to accommodate your own requirements.
Veneers and implants Not long ago had get the job done carried out here and need to say I was quite impressed. I have struggled with my teeth for quite some time and was quite impressed with the effects that was obtained. I opted for veneers and implants which to my surprise there was no discomfort because of Dr Karein. Cheltenham dental spa and dr karein is the greatest dentist undoubtedly I have ever been to as they make you really feel so at simplicity and receptionists are also brill also.
Right after back again suffering dental difficulties is probably the top brings about of time shed from operate. In today of business downsizing and position insecurity, you need to be at perform and at your very best if you find yourself there.
For those who’re entitled to NHS dentistry, treatment plans that happen to be clinically essential to sustain fantastic oral overall health such as dentures, crowns and bridges, can all be carried out within the comforting ecosystem of our methods.
Our ethos and helpful dental staff are wikipedia reference certain to make you really feel at your home, as our goal is for making the dental treatment you expertise a caring and stress-free a single. Generating you and your spouse and children experience confident and comfortable coming to see us.
Cheltenham kaupungin keskustassa sijaitseva Central Lodge tarjoaa ilmaisen pysäköinnin, ilmaisen WiFi:n ja itsepalveluhuoneita, joissa kaikissa on jääkaappi ja uuni-/mikroaaltouuniyhdistelmä. The hotel was extremely near the city Middle.
Lisah is usually a all-natural to nursing and considering the fact that becoming a member of us final yr she has in excess of established herself don't just to us but in addition Gloucestershire Faculty in which she is finding out.
Make sure to bring your dental insurance coverage card and helpful hints a photograph ID to your initial dental appointment. Consider to arrive not less than 10 to 15 minutes early so you have plenty of time for you to complete The brand new individual paperwork.
Before achieving Expert status being an Orthodontist, Tomos researched paediatric dentistry, maxillofacial surgical procedure together with basic resource dental care.
We satisfaction ourselves on having an outstanding workforce committed to our individuals and their care. Our follow has not long ago altered its opening hrs to provide adaptability for early and late appointments. We may also be one of the only dental methods in the area to supply on-web page car or truck parking.
He is a university student of Chinese Martial Arts and enjoys cooking far too – both of those on the distress and delight of his spouse and children!

domain: health


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The burden of disease for myotonic dystrophy (DM) is multi-systemic, including skeletal muscle weakness, fatigue, cardiac arrhythmias, respiratory insufficiency and intellectual disability. Modeling of this constellation of symptoms is important for mechanistic studies and preclinical therapy development. Yet, what is arguably the most widely available mouse model, the HSA-LR, is designed to model the skeletal muscle molecular, structural and functional deficits of skeletal muscle.
Dr. Guey-Shin Wang and colleagues at Academia Sinica (Taiwan) developed an EpA960/CaMKII-Cre mouse that carries an inducible human DMPK with 960 CTG repeats in the 3’ UTR. Cre expression occurs in the forebrain (cortex and hippocampus) after two weeks of age, preserving earlier neurodevelopmental events from toxic RNA exposure and MBNL depletion.
Atrophy of the cortex and corpus callosum, features of the myotonic dystrophy type 1 (DM1) patient central nervous system (CNS), were observed in the adult EpA960/CaMKII-Cre mice. The mice showed progressive neuropathological findings: reduced MBNL1 in dendrites of cortical layer V neurons at six months of age, brain atrophy (axon and dendrite pathology) by nine months, and loss of MBNL2 and MBNL-directed splicopathy were later events, at 12 months.
Functionally, EpA960/CaMKII-Cre mice were evaluated at six months for hippocampus-dependent spatial learning and memory using the Morris water maze—escape latencies were greater for mutants compared with controls, suggestive of slower learning. Evaluation of long-term potentiation (LTP) in hippocampal slices at six months of age also was consistent with synaptic dysfunction and the functional learning disabilities seen in these mice.
The EpA960/CaMKII-Cre mouse model recapitulates some features, including disease progression, seen in DM1 patient CNS. Moreover, the authors suggest that depletion of MBNL1 and MBNL2 in the CNS are distinct events with differing roles in disease progression. Early synaptic dysfunction may be triggered by MBNL1 depletion, and is a precursor to dendritic and axonal pathology. Since splicing changes were detected only later, commensurate with MBNL2 depletion, the early synaptic dysfunction likely is mediated by MBNL1-related, but alternative splicing-independent events.
Reduced Cytoplasmic MBNL1 is an Early Event in a Brain-specific Mouse Model of Myotonic Dystrophy.
Wang PY, Lin YM, Wang LH, Kuo TY, Cheng SJ, Wang GS.
Hum Mol Genet. 2017 Mar 24. doi: 10.1093/hmg/ddx115.


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A fantastic, all purpose base made with NO PALM OIL. Use 'as is' or simply add your own essential oils, fragrance, colour or exfoliants.
Coconut Oil, Safflower Oil, Glycerine (kosher, of vegetable origin), Purified Water, Sodium Hydroxide (saponifying agent), Sodium Stearate, Sodium Myristate, Sorbitol, Sorbitan Oleate (emulsifier), Oat protein.
I keep this on hand to whip up quick batches for myself or friends. It is a versatile product as I can add many extra ingredients to personalise
I wanted to make a coffee scrub soap. After much research I chose this bar as my base. An outstanding soap. Easy to melt and it set beautifully. Thanks you
I really like the palm free melt and pour soap. It melts easily and is also lovely to use. It takes mica and fragrance well too

domain: chemistry


GOSH to be first in UK to offer groundbreaking cancer therapy
27 Nov 2018, 8:51 a.m.
Great Ormond Street Hospital (GOSH) is to become the first hospital in the UK to offer a pioneering cancer therapy, known as CAR-T therapy, to NHS patients with B-cell acute lymphoblastic leukaemia (ALL). The first patients begin treatment at GOSH this week.
CAR-T therapies are specifically tailored for individual patients and work by harnessing the patient’s own immune system to fight cancer. In a complex manufacturing process, immune cells are taken from a patient’s blood and reprogrammed to specifically target and kill cancer cells.
ALL is a severe form of leukaemia that affects around 600 people per year, most of whom are children between the age of 2 and 5 years. Although the outlook for children with ALL has dramatically improved over the last decade, 10–15% of patients still do not respond to standard treatments. The new therapy has been shown to be effective in treating patients with particularly aggressive or relapsed cancers, where other treatments have failed.
Dr Peter Steer, Chief Executive of Great Ormond Street Hospital said: “I am delighted GOSH will be providing this pioneering treatment. As a leader in the field for developing personalised medicines for children and young people, GOSH has a proven track record in delivering this type of advanced cancer treatment. We aim to help every child we see fulfil their potential. Offering CAR-T therapy does exactly that.”
Dr Sara Ghorashian, Consultant in Paediatric Haematology at GOSH said: “CAR-T therapies represent a new era of cancer treatments and it’s fantastic that GOSH will soon be able to provide this cutting-edge therapy to children for whom other treatment has not worked. These groundbreaking treatments offer the real chance of a long-term cure so this is a major step forward for the families affected by this devastating condition.”
Since 2012, GOSH has treated over 25 patients from all over the UK with CAR-T therapies as part of several different clinical trials. GOSH led one of the first clinical studies of CAR-T cell therapy for paediatric leukaemia in Europe which was launched in 2013. In 2015, the hospital successfully treated the first patient in the world with gene-edited 'universal' CAR-T cells. Researchers at GOSH continue to innovate in the field of personalised medicine and are currently exploring the use of 'next generation' CAR-T cells to further reduce the chance of relapse. This underlying research was supported by the National Institute for Health Research (NIHR) GOSH Biomedical Research Centre, GOSH Charity and a range of other funders.
GOSH’s commission to provide the drug follows a deal between manufacturer Novartis and NHS England, announced by Simon Stevens in September and a site accreditation process by NHS England. Tisagenlecleucel (also known as Kymriah) is licensed to treat patients up to 25 years old with relapsed or refractory B-cell ALL.
Ancient gene mutation found as the cause of rare hereditary condition for GOSH patient.
UK scientists have found that a 7,000-year-old genetic mutation is responsible for a rare form of hereditary motor neuropathy (HMN).


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Green Foods Hydrolysed Collagen is incredible, high-quality collagen that has been broken down into short peptide chains (that’s the hydrolysation process) so that it’s easier for the body to absorb and utilize. The quicker your body can avail itself of the collagen, the faster you may reap the benefits.
Collagen, roughly meaning “something that produces glue,” is the primary structural protein found in our skin and other connective tissues. In essence, it’s what holds our bodies together, and it’s incredibly abundant; collagen makes up a whopping 30 percent of our total cache of protein and accounts for 30 percent of our bones, 60 percent of our cartilage, up to 80 percent of our skin, 80 percent of our tendons and 90 percent of the sclera (also know as the whites of your eyes). Because of the proliferation of collagen within our bodies, it’s almost impossible to name an organ, system or function that isn’t affected when you suffer from collagen insufficiency.
Ideally, your body is making collagen every day, but the aging process leads to a natural decrease in collagen production and that can create some obvious deficits.
• Promote muscle health
• Strengthen bones
• Support healthy skin and nails
• Reduce wrinkles and other signs of aging
• Protect your gut
• Combat hair loss
• Contribute to flexibility and joint mobility
• Maintain eye health


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The Fécunda is a dystopian romance which describes the human condition before and after first contact with aliens. It deals with the collapse of civilisation and comes to around 250 pages (78k words). It is the first of a two novel sequence; the second novel is called The Xenocotrix.
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The Fécunda begins in the Late Pleistocene and then alternates between a post apocalyptic future (where most of the action takes place) and the present day.
Triste is a mercenary. He plies his trade hunting the ruins of New York, now known as FUA 1 – Former Urban Area Number One. The place is shunned, with good reason; it’s the haunt of perdokhi. These creatures are the result of a xenogenetic pandemic that reduced most people to sub-human brutes. What’s left of America hides in enclaves. The former urban areas are no longer safe; the perdokhi breed fast and they are mutating and FUA 1 is a hotspot. This situation helps obscure other things, such as a covert alien base, and Redmann. Redmann have found a way to live unmolested amongst the perdokhi. Their line of business puts them beyond the law. Naturally they are secretive.
Shoe is a Redmann; too long has she lived among them. She needs to escape. It will be risky because she’s not like normal humans. Besides, Redmann’s reach is long; but she has a plan. She falls in with Triste. Triste’s current mission is to survey an abandoned laboratory. He relies on drugs to augment his survival instincts, soon he’ll have to return to civilisation – he thinks he’s rescuing her.
He doesn’t know about Redmann and it would be better if things stayed that way; they’d be enemies if he knew what she was. She is careful. A relationship develops. They locate his mission target and stumble across information relating to the collapse of the West. Ultimately, this ties in to the present day narrative, which is centred on the very same place – a genetic research laboratory.
The pandemic had other consequences. It prevented Earth from joining the interstellar community and those aliens who turned up for first contact are also trapped here. They blame humanity. Some of them see opportunities for mischief.
Shoe isn’t as defenceless as she seems. Time is running out.
The Fécunda is a character driven adventure. It takes in pre-history, snippets of science (such as Darwin’s theory of evolution) and speculates on why aliens interested in this remote planet, might prefer to remain unnoticed.
* * *
[to be added]
* * *
→→ Star Crossed
→→ Late Pleistocene
→→ Star Beings
A High Place
→ Cradle Hood
→ Peer Pressure
→ Observer Effect
la belle époque
→ Near Earth Object
→ Xhenogie Corp
* * *
The Fécunda is currently available only in the following combined editions:


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Tangala house details:
Location:On the banks of the Zambezi River, upstream of the Victoria Falls.
Best time to visit:March on wards talk to me about the seasonality of the Falls
Tour the Falls, Flights over the Falls, River Rafting, Canoe on the Zambezi,Arts/ Crafts, Cultural, Golf,Wildlife
Tangala House is a luxurious family home on the banks of the Zambezi River. It lies 15km upstream of Victoria Falls.
The house has four bedrooms, three with ensuite bathrooms, and a 12m private swimming pool.
Stylishly designed and furnished it has featured in House and Garden magazine in the UK and comes with a vehicle and boat chef,waiters and private guide all courtesy of Tongabezi.
Ideal for a Zambia family safari,Tangala House sleeps up to 8 and has a children’s playroom and a spacious kitchen-dining room.
The rooms are enclosed, with large glass fitted windows to keep out the insects and allow guests to enjoy magnificent views across the Zambezi.
Over 145 species of birds have been spotted from the kitchen window and elephant herds can often be seen drinking on the opposite bank.
The living room has a large sofa and two armchairs and leads onto a ‘snuggery’ with satellite TV, video, Hi Fi and Jetmaster fireplace. Most of the rooms have very high thatch ceilings and the passages have large 3-4m high ‘Moroccan’ arches, with 1m thick walls.
The swimming pool is 11m x 5m, with an extra shallow area for children and bench seating. In front of the house is a grass lawn and Tangala features 250m of private river frontage, with no properties on either side.
The veranda easily seats ten, and is open thatch with steps onto the lawn, towards the swimming pool and the terrace, which has an eight seat railway sleeper picnic table.
Tangala House is available to book over the Christmas and Easter Holidays,plus June,July and August Other dates throughout the year are available on request only.
There is a minimum stay of 3 nights for safari holidays and a minimum occupancy of four people.

domain: travel


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Around 1,100 cinema halls and multiplexes across Tamil Nadu stopped screening films on Monday with distributors and theatre owners going on an indefinite strike against an additional 30% tax over and above the newly implemented GST.
Under the Goods and Services Tax, film businesses have to pay taxes to the tune of 28 per cent for tickets over Rs 100 and 18 per cent for those priced below Rs 100. Tamil Nadu is the only state in India charging an extra tax in addition to GST.
Office bearers of the Tamil Nadu Theatre Owners association, Tamil Film Producers Council and distributors association on Monday met chief minister Edappadi K Palaniswami and various TN ministers for the past few days to discuss this issue.
Earlier, TNTODA President Abhirami Ramanathan made it clear that they were against the local body levy.
“We are against the Corporation (entertainment) Tax which is 30 per cent. This is in addition to the GST rates (of upto 28 per cent). We are not against the GST. We welcome it,” he said.
Actor Vishal said though the State government officials have sought another day to look into the issue the strike would continue on Tuesday as well. The TFPC president said that they would once again meet with relevant officials on Tuesday evening.