The effect of feed water TDS on RO membrane rejection rates and performance
Du Toit, Philip Thomas
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Power generation is a major user of fresh water, which is becoming important for Eskom and South Africa due to the water-scarce status. Therefore, the water usage at a thermal power station is a key metric and reverse osmosis (RO) is a key technology that can be used to reduce water consumption. A double pass RO system at a thermal power station used to produce demineralised water for steam production is operating with a large variance in its brackish feed water with total dissolved salts (TDS) ranging between 80 and 1000 mg/L. The reference plant showed a significant decrease in observed salt rejection with lowering feed water concentration. The reason for this decrease in salt rejection was not clear to Eskom and required further investigation. An experimental test rig was used to study 4” spiral wound membrane modules to replicate the reference plant in a small-scale and controllable setup. The range of feed water concentration was replicated by treating NaCl solutions varying from 10 - 2500 mg/L. Polyamide RO Membranes from three different suppliers (Filmtec™, Toray and Hydranautics) were tested to compare the response in salt rejection to feed water concentration. The test rig was not temperature controlled, and therefore, more than one variable changed during the experimental data collection which requires the development of a model from literature and experimental data to enable the comparison between the membranes on an equal footing. The results produced by the standard salt diffusion equation significantly deviated from the experimental results below 100 mg/L NaCl feed concentrations. This deviation was attributed to the Donnan effect which showed a reduced effect at lower concentrations and subsequently lowers the salt rejection capability of the RO membrane in this region. Therefore, additional terms presented by Anisimov & Orlov (2018) were incorporated into the salt flux equation which then produced a model that predicts the membrane performance throughout the entire feed concentration range that was tested. The experimental input data is also replicated using the modelling software available from the three membrane suppliers. The results from the software correlated well with the experimental and developed model results. The recommended modifications from an optimisation exercise on the reference plant could allow the plant to be more flexible by achieving maximum recovery over the entire range of feed water qualities. The modifications proposed can potentially allow the reference plant, when operating on the lowest feed water concentration, to increase overall water recovery from 77% to 96%, reduce wastewater by 80% and increase the plant production by 23%.
- Engineering


Retired police superintendent Franklin Chu could finally face criminal investigation for assaulting a passerby during the Occupy protests in October 2014 in Mong Kok, Apple Daily reported Monday.
Osman Cheng, who was allegedly hit by Chu with a baton, was quoted as saying that the police invited him to give a statement just before the Lunar New Year holiday.
The move suggests that a criminal investigation is underway into Chu, more than 450 days after he is said to have assaulted Cheng.
Cheng was told that the statement taken from him earlier was mainly used for a petition he made against Chu at the Complaints Against Police Office (CAPO), whereas the new statement would be for a criminal investigation.
A Department of Justice (DOJ) spokesperson confirmed that the police sought legal advice on the Chu case, the report said.
The police, meanwhile, said that they are following up on DOJ’s reply and that they have no further comments to make at this stage.
The alleged assault took place on November 26, 2014 in Mong Kok, where Chu was accused of hitting several people, including Osman Cheng, with a baton.
One day ahead of Chu’s official retirement last July, the Independent Police Complaints Council (IPCC) established a complaint against Chu with a voting result of 12 for and six against. The CAPO sought advice from DOJ after disagreeing with the decision of IPCC.
Eric Cheung Tat-ming, an assistant professor at the University of Hong Kong’s Faculty of Law and a former IPCC member, said it is highly likely that a criminal investigation has begun, given that the police have sought statement from a witness.
Cheung said the police probably would pursue a common assault charge. A charge of assault causing bodily injury could be handed out if the injuries sustained were considered severe, he said.
As Chu was a superintendent, veteran police officers said his case would be handled by the Civil Service Bureau, and that it is more likely he would be given a written warning.
With Chu having already retired on July 23 last year, it is likely that he will be able to continue to receive his pensions, as the charges were not as serious as the likes of corruption, murder or rape.
- Contact us at [email protected]


KJT has exported conveyor belt safety switches to global market with high quality. KJT's main products include miniature inductive sensor series. The product features uniform quality of air circulation. The atmospheric temperature and relative humidity have been homogenized to keep it reasonably uniform. This product can exactly meet the requirements of location check, signal transmission, automatic counting, and velocimetry. KJT has engaged in miniature inductive sensor industry for many years and confident in its quality. Thanks to its stainless steel housings, this product features increased overload protection. .
In developing and expanding process of the enterprise, our teamDQ actively carries out the concept of Corrosion resistant proximity sensor. Get more info!


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Now Offered For Sale – Super Sweet
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If you’re looking for a really cute condo in the downtown area of
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Are you looking to buy a home or condo in the
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domain: geography


text:
A perfect summer entertaining recipe featuring fresh blueberries, cherry tomatoes, basil, and mozzarella. Check to see if balsamic is on your menu plan. If not us a nice olive oil and apple cider vinegar mix for dressing.
Incredible Baked Meatballs: 1 lb pound hamburger 2 eggs, beaten with cup milk cup grated Parmesan 1 cup panko or bread crumbs 1 small onion, minced or grated cloves garlic, minced tsp oregano 1 tsp salt freshly ground pepper cup minced
Honey Orange Grilled Chicken - Plain Chicken - only 4 ingredients! Orange juice, honey, Italian dressing mix and chicken. Marinate for an hour and grill. SO easy and super delicious! We doubled the recipe and ate leftovers the next day.

domain: food


WASHINGTON — The Senate Intelligence Committee is looking at the presidential campaign of the Green Party’s Jill Stein for potential collusion with Russians, a sign that the panel’s probe is far from over, even as allegations swirl that the House panel’s investigation is racing to a close.
Senator Richard Burr, Republican of North Carolina, said Monday the Senate committee has started looking into Stein’s campaign. Burr had indicated previously the committee is also looking into reports the Democratic National Committee paid for research that went into a dossier detailing allegations of Donald Trump’s exploits in Moscow.
Stein, a Lexington physician, was present at a 2015 dinner in Moscow that was also attended by Trump’s former national security adviser, Michael Flynn, whose contacts with Russian officials have been a chief focus of investigations. Flynn and Stein sat with Russian President Vladimir Putin.
The expansion of the investigation to include Stein suggests that the Senate intelligence probe it will continue well into next year. That stands in contrast to the House, where Democrats have been charging that Republicans are pushing the House Intelligence Committee to finish up its investigation by the end of this year — before, Democrats say, it can be responsibly completed.
The House Intelligence Committee this week has or is scheduled to interview a number of high-profile witnesses, including: Rob Goldstone, the music producer who helped set up a meeting with a Russian lawyer at Trump Tower in June 2016; Andrew McCabe, the deputy director of the FBI; Felix Sater, a Russian-born businessman who was a close associate of Trump’s; and Rhona Graff, Trump’s longtime aide and often referred to as the ‘‘gatekeeper’’ for Trump Tower. The interviews of Graff and Sater are expected to take place in New York — another sign, Democrats say, that House Republicans are rushing.
Burr pushed back Monday on reports that the House Intelligence Committee would soon shut down its probe.
‘‘I've heard the House guys actually say that’s not true,’’ Burr said.
Representative K. Michael Conaway of Texas, who is running the House’s investigation, would not answer questions Monday about the probe’s timing, even as he confirmed the Goldstone and McCabe interviews. Conaway said he would not be attending this week’s interviews in New York.


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After strenuous exercise, it results in better recovery
When you're new to some intense training sessions then muscle soreness is much likely to occur and then it becomes a lengthy process for recovering from strenuous exercise. Luckily, after strenuous workouts pants and shorts from compression pants suppliers can help in muscle recovery.
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domain: health


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Tanzania is a peaceful, politically stable country and certainly safe for tourists. However, visitors are advised to take general precautions for personal safety.
- If you want to sight see on your own in nearby cities, please check with your guide before you go. If you prefer to explore nature alone, please check with your guides or rangers as the animals at national parks are wild.
- If you choose to walk at night, some areas are more secure than others. Be cautious.
- It’s advisable to be practical with attire and jewelry as some of the items may attract things that are not expected. For instance, Tse Tse Flies are attracted to brighter colors.
- It’s advisable to carry replaceable items, so if they get lost, they can easily be replaced.
- As you travel, your instincts will guide you on where to go and how close you want to be with wildlife. Please listen and communicate to others about how you feel.

domain: travel


Allah Las announces new album LAHS and releases first single In The Air
23 July 2019
Allah Las have always been fascinated with both the carefree spirit and glitter-in-the-gutter lifestyle of their hometown LA. After three records mining its lore and lure (from the desert to the sea) and having taken their compact California on the road across the world, they couldn’t help but peek through the other end of the telescope. On their fourth LP, drummer Matt Correia, bassist Spencer Dunham, and guitarists Miles Michaud and Pedrum Siadatian turn their collective gaze outward and toward the horizon. 'We’ve been travelling a lot the past couple years and I think that played a role in influencing the broader variety of songs on this record', Correia explains. Simply titled LAHS (a reference to a common misspelling of the band’s name), their forthcoming release on Mexican Summer finds a band at the peak of their powers. LAHS will be released on October 11th through Mexican Summer.
Take the persistent shuffle of first single In The Air that drives the song, while Siadatian’s echo slapped voice bounces along on top, describing''images that can’t compare to the real thing in the air''. Electric guitar and mellotron trade licks, mirror each other's kinetic ascending and descending lines and call to mind the playful jubilance of Kevin Ayers in his prime.
Those familiar with the band’s work will recognize their skilful melding of melodies and moods, but through a wider lens we see them venturing into new, exciting territories on LAHS. Indeed, their growth not just as songwriters, but as performers, arrangers, and producers - is clearly audible - quite literally, with songs also sung in Portuguese and Spanish.


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Mechanical neck pain is a result of degenerative disc disease and arthritis of the facet joints of the cervical spine. Mechanical Neck Pain is a condition that can become chronic due to degenerative disc disease and arthritis in the neck, with the source of pain coming from the spine and its structure. This happens when one of the joints in the spinal area loses its normal resiliency and shock absorption. When a joint becomes dysfunctional, its normal range of movement may be affected and it can be rather painful.
Dysfunctional joints may turn into muscle pain, and even affect the nervous system. This may happen because of the high amount of nerve receptors in the joint. Any muscles related to the joint can become tense and underactive. The muscle imbalance can cause additional stress on the joint, aggravating the joint dysfunction that exists already. Nearly any joint in the spine, from the neck all the way down to the sacroiliac joints, can cause pain. When the joints aren’t being used on a regular basis, degenerative pain occurs.
What Causes Mechanical Neck Pain?
- Degenerative issues with the cervical spine, the mechanical parts that allow us to move our head up
and down and around
- Minor strains or sprains to muscles or ligaments in the neck
- Bad posture. For example, neck pain is more common in people who spend much of their working day at a desk, with a ‘bent-forward’ posture.
- Sometimes the exact cause is unknown.
Symptoms of Mechanical Neck Pain
- Mechanical Neck Pain will not only induce pain in the neck, but also in the shoulders, and upper back
- Neck pain tends to worsen with movement
Neck Pain due to Whiplash
Whiplash syndrome is a collection of symptoms that result when there is soft-tissue injury of the cervical spine. Whiplash is very common whenever the head is forcefully jerked forward, back, or both. It is a common injury with automobile accidents. In fact, many people have suffered whiplash even in low impact car collisions. It is also common for someone to have a delayed onset of whiplash, where the person does not realize that they have had a whiplash injury. When this occurs, usually at some future point in time, that patient will begin to present with some of the classic signs of a whiplash injury.
What Causes Neck Pain from Whiplash?
The rapid and forceful movement that jerks the head forward and back, causes major strain to the cervical spine. Though most often associated with a rear-end collision, whiplash can also occur from a sports injury, physical abuse or trauma.
The most common whiplash symptoms are:
- Neck pain and/or stiffness
- Blurred vision
- Difficulty swallowing
- Pain between the shoulder blades
- Pain in the arms or legs, feet and hands
- Low back pain and/or stiffness
- Shoulder pain
- Ringing in the ears
- Numbness and tingling
- Pain in the jaw or face
Cervical Herniated Disc
The back is composed of bones, joints, discs, ligaments and muscles. The bones that run from the neck down the spine are called vertebrae. In between each vertebra is a disc. These discs have three main functions:
- Act as a shock absorber between adjoining vertebrae.
- Act as joints that allow for mobility in the spine.
- Act as ligaments that hold the vertebrae of the spine together.
In order for a disc to function properly, it must have high water content because this makes the disc strong yet flexible. As long as the disc is well hydrated and undamaged, it has the ability to support heavy loads.
Injury, poor body mechanics and poor nutrition can cause the disc to become dehydrated. This causes the disc to lose its ability to support the spinal bones during everyday living. This can result in disc injury such as a bulge or herniation.
When a cervical (neck) disc becomes herniated, it can cause pain in the neck, shoulders, chest, arms or hands. Arm pain from a cervical herniated disc is one of the more common cervical spine conditions found in the 30 to 50year-old age group. Even though a herniated disc may happen due to some form of injury or trauma to the cervical spine, more often than not, the symptoms seem to appear rather spontaneously. Arm pain due to a cervical herniated disc occurs because the disc material presses or pinches on a cervical nerve, causing pain to radiate down the nerve pathway of the entire arm. In addition to pain, a person may experience weakness, numbness, and tingling in the arm.
What Causes a Cervical Herniated Disc?
As we age, ligaments surrounding the discs become less flexible and elastic, making them brittle and more easily torn. This can also prevent important nutrients and hydration to get to the disc to keep it healthy. When a disc herniates, it puts pressure on nearby spinal nerves or the spinal cord, and this is what causes all that pain.
Symptoms of a Cervical Herniated Disc
- Neck, shoulder and/or arm pain
- pain ranges from dull, aching and hard to locate to sharp, burning and easy to pinpoint
- radiating arm pain
- numbness, tingling, or weakness in the arm or hand in more severe cases
A specific cervical disc herniation has its own pain patterns and neurological problems. These are as follows:
- C5 (C5 nerve root): Can cause weakness in the deltoid muscle in the upper arm. Does not usually cause numbness or tingling. Can cause shoulder pain.
- C6 (C6 nerve root): Can cause weakness in the biceps (muscles in the front of the upper arms) and wrist extensor muscles. Numbness and tingling along with pain can radiate to the thumb side of the hand. This is one of the most common levels for a cervical disc herniation to occur.
- C7 (C7 nerve root): Can cause weakness in the triceps (muscles in the back of the upper arm and extending to the forearm) and the finger extensor muscles. Numbness and tingling along with pain can radiate down the triceps and into the middle finger. This is also one of the most common levels for a cervical disc herniation.
- T1 (C8 nerve root): Can cause weakness with handgrip. Numbness and tingling and pain can radiate down the arm to the pinky finger side of hand.


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20 cats who stick out their tongues to defy their humans
What do we think about humans? Pfffttttttttttt. Stoopy.
Now go on fellow cats, stick your tongues out and let your humans know how stoopy they iz!
(FYI - your cat sticking out its tongue iz nothing serious and cute, but - if your kitty does this very frequently - as in multiple times a day - you should take them to the vet. It could be a medical condition that needs to be addressed.)
images via reddit
Commentscomments powered by Disqus
Happy International Cat Day!
How I know there's a bug in the house
Still fits and sits
How to use a cat harness
How to safely use a cat harness
Being your cat's biggest supporter
Happy 4th of July!
Life is so unfair

domain: pet


text:
The first wave of modern Jewish migration to Ottoman-ruled Palestine, known as the First Aliyah, began in 1881, as Jews fled pogroms in Eastern Europe.
The Second Aliyah (1904–14), began after the Kishinev pogrom; some 40,000 Jews settled in Palestine, although nearly half of them left at a later point in time.
Both the first and second waves of migrants were mainly Orthodox Jews, although the Second Aliyah included socialist groups who established the kibbutz movement.
During World War I, British Foreign Secretary Arthur Balfour sent a letter that stated:
His Majesty’s government view with favour the establishment in Palestine of a national home for the Jewish people, and will use their best endeavours to facilitate the achievement of this object, it being clearly understood that nothing shall be done which may prejudice the civil and religious rights of existing non-Jewish communities in Palestine, or the rights and political status enjoyed by Jews in any other country.”
The Jewish Legion, a group primarily of Zionist volunteers, assisted in the British conquest of Palestine in 1917. Arab opposition to British rule and Jewish immigration led to the 1920 Palestine riots and the formation of a Jewish militia known as the Haganah (meaning “The Defense” in Hebrew), from which the Irgun and Lehi, or Stern Gang, paramilitary groups later split off.
In 1922, the League of Nations granted Britain a mandate over Palestine under terms similar to the Balfour Declaration.
The population of the area at this time was predominantly Arab and Muslim, with Jews accounting for about 11%.

domain: politics


PC with Zero moving parts
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March 30, 2009, 09:36 AM
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If you make the case one big heatsink , and thermally connect all the hot parts to it (heatpipes) convection can easily take care of the cooling.
It's something I've been considering fooling around with...copper milling aint cheap tho.
24+SB cores , 7x Asus Strix 1070's ,storage, memory n stuff.Dual 4k monitor video .
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Every Manual available online - found by our community and shared for FREE. Enjoy!
The Ford Motor Company (commonly referred to as simply Ford) is an American multinational automaker headquartered in Dearborn, Michigan, a suburb of Detroit. The Ford 53 Motorhome is an A Class stripped motorhome chassis from Ford Motor Company Since 1999. . It is offered with a powerful 6.8 L EFI Triton V10 engine with a 5-speed TorqShift® automatic transmission. This Transmission is designed for tough commercial-duty applications. The F-53 has a standard GVWR of 16 tons which can be upgraded to 26 tons. For safety purpose it is equipped with 4-wheel disc anti-lock braking system (ABS).
Get notified for new manuals?
We'll send you a quick email when a new Buick Verano manual is added.


text:
District Attorney Candidate Debate — A Voter Game Plan Event
This race has attracted national attention, because it's the latest—and largest—battleground in a national push to get reformists elected as district attorneys.
Incumbent Jackie Lacey is L.A.'s first African-American D.A., but she is being challenged by former San Francisco D.A. and Police Chief George Gascón. (He's also a former LAPD assistant chief.) Lacey is under attack from Black Lives Matter activists for not prosecuting more cops, but was Gascón's record any better in San Francisco?
Watch the archive video above to find out more about the candidates and their plans to enact meaningful reform in the criminal justice system. KPCC/LAist Public Safety Correspondent Frank Stoltze and L.A. Times Criminal Justice Reporter James Queally moderated the debate.
This event is presented in partnership with L.A. Times.

domain: news


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Pacific Tool & Gauge 375 Cheytac finish chamber reamer and chamber gauge. Used once, immaculate condition. No burrs or chips. $197 for reamer and $67 for gauge, new. Sell for $200 shipped. PayPal ff or split seller cost or US money order.
My Smith says it's the STD Cheytac reamer. No modifications were made to the chamber off of original. PTG can email a print off my order# if needed. I can say my rifle shoots .5 moa with Cutting Edge 350gr. Stiller, Bartlein, Manners.


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Leger McInnes, the west of Scotland's finest feline sleuth and amateur sculptor, is back and the crimes he solves are becoming more and more disturbing.
This compilation edition comprises the novelettes Leger's Sidekick, where he sets out to find an arsonist, the murder mystery Leger's Island and Leger's Secret where he must unmask a cat hating vandal.
Released after Leger's Secret, I considered holding this back until Leger's City came out but decided to keep the books in chunks of three. It was after the release of this one that I decided to remove that beautiful image of the cat from the Volume 1-5 compilation and use another. For a while, this was only available in paperback.
Release Date: 8th July 2014

domain: library


Canada: Massive Alberta wildfire expected to burn for months
- The images are ones of devastation - scorched homes, virtually whole neighborhoods burned to the ground. It began to rain a little Sunday morning just south of Fort McMurray, but Canadian officials say they expect to fight the massive wildfire that has destroyed large parts of Alberta's oil sands town for months.
There's fear the growing wildfire could double in size and reach a major oil sands mine and even the neighboring province of Saskatchewan.READ MORE: Canada: Alberta declares state of emergency in Fort McMurray; Much of city could be 'destroyed' by wildfire
Morrison said the fire was burning away from communities this weekend. He expected cooler temperatures and expected some rainfall Sunday, but significant rainfall is needed.(Excerpt) Read more at: hosted.ap.org ...
- Photo credit(s): hosted.ap.org


Metal Cleaning Systems
Multiple combinations of magnetic and electronic separators can be used to meet your specific requirements. Cleaning Systems are designed for maximum protection against ferrous and nonferrous debris by combining magnetic and electronic separators. They are the perfect solution for purifying regrind and recycled goods in a plastics plant.
Metal Cleaning Systems provide an all-metal removal solution utilising both magnetic separation and metal detection in one combined unit. The combination reduces product loss, especially when metal contamination levels are high. The primary stage magnetic separator (FF Drawer Filter Magnet) captures magnetic metals (commonly making up the largest proportion of metal contamination) leaving the quickTRON 03R or 05A metal detector to focus on identifying and removing non-ferrous metallics.
Key Features include:
- Adjustable sensitivity and rejection cycling on the metal detector reduces the loss of good material
- Automatic Product-Effect Compensation on the metal detector increases metal reject accuracy
- Open frame construction provides easy access to all components
- The metal detector electronics are sealed against dust
In operation, the product (e.g. plastic beads, regrind, free-flowing resins, etc) flows under gravity into the feed hopper and through the high-strength neodymium tube magnets of the FF Drawer Filter Magnet. Ferrous metal contamination, as well as weakly magnetic abraded stainless steel, is attracted to and held on the surface of the tube magnets.
The remaining product falls down and into the infeed pipe of the quickTRON 03R or 05A metal detector housing the detection coil. When detecting a small and fine particle of either entrapped or free tramp metal, the control sends a signal to move the high-speed stainless-steel reject flap. The metal contamination, along with a small proportion of product, is rejected from the main product stream. The reject flap then returns to holding position to allow the flow of metal-free material. The reject time is adjusted to suit the installation.
The metal detector is supplied with an anti-static sensing tube. This prevents static build-up in and near the search coil avoiding false rejects due to static discharge.
The control allows product effect compensation to guarantee continuous detection sensitivity and trouble-free operation even with ‘difficult’ products.
Typical tramp metal captured by the magnetic separator and removed by the metal detector includes:
- Nuts and bolts
- Broken screens
- Metal from shredder and granulator blades
- Abraded stainless-steel
The Metal Cleaning System comprises of:
Metal Cleaning Systems are primarily designed for the plastics sector, but are also used in other applications where the product is dry and falling under gravity:
- Plastic manufacturing and recycling operations;
- General powder and bulk handling;
- Dry food processing plants;


text:
- Research article
- Open Access
Three monthly doses of 60 mg/kg praziquantel for Schistosoma haematobium infection is a safe and effective treatment regimen
BMC Infectious Diseases volume 20, Article number: 323 (2020)
Praziquantel (PZQ) is the standard treatment for Schistosomiasis in sub-Saharan Africa. However, there is evidence suggesting praziquantel treatment failure in Schistosome infections with associated potential renal impairment. The objective of this study was to determine the effect of three monthly doses of 60 mg/kg/day PZQ on schistosome egg count, liver and renal function during the treatment of urinary schistosomiasis in Ghana.
A nested case-control study was designed from a cohort screened for schistosomiasis; 28 schistosomiasis positive cases by microscopy matched with 53 healthy controls by age and gender. The study population was urban dwellers from the Asokwa sub-metropolitan area, Kumasi in Ghana. Participants were within the age range of 6 to 30 years. We assessed Schistosoma haematobium egg counts in urine and its associated impact on liver and renal function at baseline, treatment and post-treatment phases using serum.
Of the 28 cases and 53 controls, 78.6% and 81.1% were males respectively. Globulin levels before treatment was higher in cases [36.7 (32.8, 40.1) vrs 30.5 (22.4, 33.8), p = 0.005] at pre-treatment but not at post-treatment [35.8 (31.2, 39.1) vrs 37.4 (29.7, 43.0), p = 0.767]. Estimated cure rate was 42.9, 46.4 and 96.4% after first, second and third dose respectively. Schistosome egg counts dropped significantly (p = 0.001) from before second dose to post-treatment. Similarly, levels of alanine aminotransferase (p = 0.001), aspartate aminotransferase (p = 0.028) and gamma glutamyl transferase (p = 0.001) significantly declined towards post-treatment. Estimated glomerular filtration rate significantly improved from before second dose to post-treatment using both the Chronic Kidney Disease Epidemiology Program (p = 0.001) and 4-variable Modification of Diet in Renal Disease (p = 0.002) equations.
Treatment of urinary Schistosoma hematobium infections with a repeated high monthly dose of 60 mg/kg of praziquantel for 3 months is safe and effective.
Praziquantel (PZQ) is virtually the sole treatment regimen for Schistosomiasis in sub-Saharan Africa . This oral schistosomicidal agent is constituted of a racemate mixture, with activity both in vivo and in vitro [2, 3]. Evidence from studies conducted on Schistosoma (S.) mansoni and S. japonicum although not very clear, indicate the mode of action of PZQ is the targeting of calcium channels and antigen exposure rendering the worm susceptible to elimination by antibodies [1, 4].
After oral administration, PZQ is rapidly absorbed, metabolized and excreted by the kidney. Metabolism of PZQ is primarily via the cytochrome P450 system leading to the production of toxic metabolic intermediates, which are potentially harmful to hepatocytes . Plasma levels of PZQ are also reported to be reduced by inducers but elevated by inhibitors of cytochrome P450 activity [6, 7].
Several studies, predominantly in Asian populations, where S. japonicum infections are endemic, state conflicting findings on hepatotoxicity associated with PZQ treatment against the helminth [8, 9]. PZQ treatment is reported to be associated with elevated serum concentrations of liver aminotransferase . However, in a large retrospective study from China, there was insignificant (less than 1%) incidence of hepatotoxicity among populations treated for S. japonicum with PZQ .
Therapy for Schistosomiasis in sub-Saharan Africa has mainly been documented based on intestinal S. mansoni infections . As a result, there is paucity of data on urinary S. haematobium and its associated drug metabolism effects on organs involved in metabolizing and excretion of PZQ. This leaves a gap in knowledge about the protective or destructive effect of metabolizing the drug in S. haematobium infection. It has further been shown that varied degrees of reduction in incidence and infection rates of S. haematobium are reported with mostly single PZQ dosage of 40 mg/kg/day in both children and adults . There are also indications of drug resistance to single doses of PZQ for treating schistosomiasis . This heightens the need to probe the outcome of repeated PZQ treatment on urinary schistosome counts against its implication on liver and renal function.
The aim of this study was to assess the effect of PZQ on schistosome egg count, liver and renal function after 3 doses of 60 mg/kg/day (PZQ60) in three months for treating urinary S. haematobium infection.
This was a nested-Case Control study conducted among children and adults of ages 6–30 years from the urban Asokwa District in Kumasi, Ghana (see plate 1). This was part of a larger study to assess plasmodium transmission in persons infected with Schistosomiasis (NCT02769013). Ethical approval was obtained from the Committee for Human Research Publication and Ethics, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Ghana. All participants were required to sign an informed consent. For minors below 16 years, a signed assent form from the participant and an informed consent from a parent or guardian were obtained. Cases were respondents diagnosed to have S. haematobium by routine microscopic examination of urine samples. Controls from the same communities, without laboratory or clinical detection of urinary schistosomiasis infection were age and sex matched with cases.
Apromase, Deduako, Emena and Kokoben were the study communities in the urban Asokwa District with a population of 140,161 inhabitants in 36, 183 households (Fig. 1) . These communities are located between latitude 6°30′ and 7°00′ North and longitude 1°30′ and 2°00 West of Kumasi, the capital city of the Ashanti Region of Ghana. The four communities have Saman (Kokoben and Apromase), Oda (Deduako) and Subin (Emena) as names of three rivers running through it.
Climatic conditions are tropical with temperatures varying from 20.2 °C to 37.1 °C. Rainfall pattern is seasonally bimodal with major rains extending from late April to August with a minor one from September to October . The average annual rainfall for the area is 6.25 mm with peaks of 214.3 mm and 16.2 mm in June and September respectively. The dry season (harmattan) is from November to March with humidity ranging between 53 and 93%.
Screening and enrolment
A census of the selected communities was conducted with the ages and number of inhabitants per building collected along with corresponding GPS coordinates using Personal Digital Assistants (PDAs). Households within the buildings were selected and their members asked for written informed consent to be screened in the study. Twenty millilitres (20 ml) of urine samples were collected once, from consenting participant into well-labelled 30 ml urine containers. The urine samples were collected within the hours of 6:00 am and 12 noon. Subsequently, the samples were kept in cold boxes at temperature of 4–6 °C until transported to the laboratory at Kumasi Centre for Collaborative Research in Tropical Medicine (KCCR) about 15–20 min drive from the study sites.
Asymptomatic schistosomiasis positive (SP) cases and schistosomiasis-negative (SN) controls based on screening results were invited to participate in the study.
A total of 1258 participants were screened for schistosomiasis out of which 104 were positive. All 104 schistosome positive participants (Fig. 2) were placed on PZQ60 treatment. Controls were selected from the same communities and matched in a 2: 1 ratio with cases by sex and age. Out of the 104 positive cases, 32 started the treatment phase with 28 successfully completing the course with samples analyzed. On the other hand, 53 controls had all samples analyzed.
Design of Experiment
Biochemical parameters and schistosome counts were analysed before and after treatment for both cases and controls (Fig. 3). In between pre- and post-treatment, the biochemical and schistosome counts were monitored before the 2nd and 3rd dosages of PZQ60 for cases.
Processing of urine and S. haematobium quantification
Freshly voided urine was collected between 6:00 am and 12:00 pm in a sterile wide-mouthed screw-top plastic container (30 ml) and transported to the laboratory on ice at 4 °C to 8 °C. Urine processing and quantification were done as described by Cheesebrough . Briefly, blunt-ended forceps were utilized to place a polycarbonate membrane filter of pore size of 12.0 μm (Whatmann Nuclepore) on the filter-support of a filter-holder (Swinnex 25 mm support chamber). The filter holder was re-assembled and attached to a 10 ml syringe filled with well-mixed urine which was filtered with the aid of the plunger. The filter was carefully removed and transferred with the face upwards to a clean glass-slide. A drop of physiological saline was added, covered with a cover-slip, and examined by two independent expert microscopists using the 10X objective (Carl Zeiss Microscope) with the condenser iris closed sufficiently to give good contrast. The entire filter was examined systematically for the presence of S. haematobium eggs. The number of the eggs counted per 10 ml of urine was recorded and the average of the two counts was calculated. A slide was declared negative when no parasites were detected.
Blood sampling and processing
Blood samples were collected from the antecubital vein with the aid of a tourniquet and the puncture site cleaned with 70% alcohol prep. Blood drawn into separator gel tubes (5 ml) were centrifuged at 1780 x g for 10 min at 4 °C to obtain the sera which were subsequently stored at -80 °C.
Assays for the liver function; albumin, globulin, aspartate aminotransferase (AST), alanine aminotransferase (ALT) and gamma glutamyl transferase (GGT) and renal function (urea and creatinine), were conducted using a chemistry analyzer (HumaStar 200, Human, Germany). Elevated levels of AST, ALT and GGT are known indications of liver damage which may be caused by drug metabolism, infections and alcohol consumption. Increase in the levels of globulin is also found to correlate with infection or an inflammatory state. Aliquots of the serum were dispensed into cuvettes after thawing and placed at pre-programmed positions in the auto-analyzer and analysis done in batches. Due to the limited strength of serum urea and creatinine as markers of renal function, renal insufficiency based on estimated glomerular filtration was used as a more robust indicator. Renal insufficiency was assessed based on the 4-variable Modification of Diet in Renal Disease (4v-MDRD) and the Chronic Kidney Disease Epidemiology Program (CKDEPI) equations . The 4v-MDRD estimates the glomerular filtration rate based on serum creatinine concentration, age, sex and race whiles the CKDEPI uses variations of an equation based on cut-offs for serum creatinine concentrations and sex.
Data were entered into excel and analyzed with Stata V.12 (StataCorp, USA). Continuous variables were reported as median with interquartile ranges and categorical variables as proportions. The Wilcoxon signed rank test was used to assess differences in continuous variables between groups with statistical significance set at p < 0.05.
Characteristics of study population before treatment
Majority of the study population were males [78.6 (62.4, 94.8) for schistosome positives and 81.1 (70.2, 92.0) for controls] with no significant statistical difference in age for the two groups (p = 0.547). Serum albumin levels were higher (p = 0.003) in controls [55.9 (52.1, 61.5)] compared with schistosome cases [51.9 (48.5, 53.0)]. On the contrary, serum globulin levels were elevated (p = 0.005) in cases 36.7 (32.8, 40.1) compared with controls 30.5 (22.4, 33.8). No significant difference was reported between schistosome cases and controls for liver (ALT, AST and GGT) and kidney (serum creatinine and urea) markers. Similarly, no significant difference (p = 0.600) was reported for estimated glomerular filtration rate (eGFR) between schistosome positive [96.0 (80.0, 116.0)] and negative [101.0 (88.0, 127.0)] groups using the CKDEPI equation before treatment (Table 1). Furthermore, the 4v-MDRD renal equation also showed no difference in levels between schistosome positive and negative groups at pre-treatment (p = 0.776).
Effect of treatment of cases with 3 doses of PZQ60 on liver, renal function and S. haematobium egg count
After the first dose, ALT levels increased significantly (p = 0.001) and gradually declined after the second dose and then significantly (p = 0.001) towards post-treatment stage (Fig. 4). AST levels were elevated (p = 0.006) after the first dose and significantly (p = 0.001) declined before the third dose. However, there was no statistically significant difference (p = 0.577) in AST levels from before the third dose to post-treatment. GGT levels increased sharply (p = 0.001) after the first dose and declined significantly (p = 0.001) after the second dose. Schistosome egg count decreased significantly (p = 0.001) after the third dose towards post-treatment.
Estimated glomerular filtration rates (Fig. 5) decreased significantly after the first dose using both CKDEPI (p = 0.003) and 4v-MDRD (p = 0.004). On the contrary, eGFR increased significantly from before second dose towards post-treatment for both CKDEPI (p = 0.001) and 4v-MDRD (p = 0.002).
Effect of treatment with 3 doses of PZQ60 on cure rate
Estimated cure rate was 42.9% a month after administering the first dose of PZQ60 (Table 2). This increased to 46.4% before administering the third dose and finally to 96.4% post-treatment.
Comparing Schistosome count and biochemical parameters between cases and controls after treatment
At post-treatment, there was no significant difference in mean levels for albumin (p = 0.441) between cases [48.8 (45.4, 52.5)] and controls [52.9 (49.6, 55.4)]. Similarly, mean levels of ALT, AST and GGT did not vary statistically between cases and controls post-treatment (Table 3). Moreover, creatinine and urea levels did not statistically vary between cases and controls. No significant difference (p = 0.753) was recorded using CKDEPI equation at post-treatment (Table 3) between the two groups. Likewise, 4v-MDRD reported no significant difference post-treatment (p = 0.866), between cases and controls.
Schistosome egg numbers declined after administration of the second dose of 60 mg/kg praziquantel and almost completely eliminated post-treatment with 96.4% cure rate. The estimated glomerular filtration rate dropped significantly after the first dose of praziquantel but resolved after the third dose. Moreover, levels of liver enzymes increased after the first dose and returned to pre-treatment levels in schistosome positive cases post-treatment.
Several studies assessing the efficacy of praziquantel treatment on S. haematobium has been based on single doses of 40 mg/kg with cure rates ranging from 39.8 to 88.9% in mainly children below 17 years [15,16,17]. In addition, multiple dose regimens have been reported to clear S. haematobium with 53.1 to 100.0% cure rates [18, 19]. We report a final cure rate of 96.4% after a monthly dose of PZQ60 for three months. Contrary to case reports [20, 21] where multiple courses of 40 mg/kg failed in clearing persistent S. haematobium infection, this study finding provides evidence of an efficacious treatment regimen with repeated and higher doses of PZQ60 which can clear Schistosome eggs and eliminate the worm stage of the parasite. This assertion is further supported by an initial increase in schistosome egg count before the second dose which could be attributed to a single dose of PZQ60 having little effect on juvenile worms as concluded in a previous study that persist and perpetuate more eggs . It is worthy of note that although praziquantel is the standard treatment for schistosome infections due to reported efficacy and minimal side effects , there are studies that have found cases of drug failure [20, 21]. However, these investigations are not definite on the causes of these treatment failures. It is also plausible that the low cure rates after the first and second dose could be attributed to some level of resistance to PZQ previously reported in S. haematobium infections  in some endemic regions and could be now present in Ghana.
With respect to organ damage, many studies have tried to analyze the efficacy of varying concentrations of PZQ on organ injury [25, 26]. However, little is known of its effect to the liver and kidney as a result of repeated and higher doses for treating S. haematobium among sub-Saharan subjects. It is well established that metabolizing of PZQ analogs by cytochrome P450 can lead to highly oxidative intermediates  which overwhelm the body’s defense resulting in varied levels of organ damage. This study found a significant increase in liver enzymes after the first dose, which steadily dropped to pre-treatment levels. The initial upsurge in liver enzymes could be explained as due to highly oxidative intermediates of PZQ than can be quenched by the antioxidant activity of superoxide dismutase, glutathione and glutathione S-transferase. Consequently, hepatic cells are disrupted leading to the release of compartmentalized liver enzymes. However, the steady return after two more doses of PZQ to pre-treatment levels could be proof of the body system’s response of mopping up toxic metabolites by inducing higher expression of cells that synthesize these proteins involved in the body’s redox systems.
Similarly, the significant drop in estimated glomerular filtration rate for both the CKDEPI and 4v-MDRD equation after the first 60 mg/kg dose shows the body’s initial intolerance to oxidative species from the metabolism of the drug which improved even after monthly repeated doses. It is plausible that sustained higher thresholds of these induced protective antioxidants persist after its initial deficit compared with the highly oxidative drug intermediates associated with organ damage. This suggests possible protective effect of monthly repeated doses of PZQ on the renal filtration with a corresponding decline in schistosome egg count.
It is possible that taking other medications with this treatment regimen may further increase secretion of liver enzymes into blood. However, data backing this assertion is lacking from this study. Moreover, the reported levels of liver enzymes and estimated glomerular filtration rates could have been influenced by viral infections and wasting of muscles respectively. Even though the study finding gives a strong indication that PZQ60 given over 3 months is safe and effective, the willingness of only 32/104 (31%) of egg positive cases to participate in the repeated treatment (Fig. 2) suggests this regimen may have low compliance. It is recommended that further research is done on improving compliance to increase treatment coverage if multiple dosing is to be employed.
This study suggests that treatment of urinary S. hematobium infections with a repeated high monthly dose of 60 mg/kg of praziquantel for 3 months is effective and safe. It provides an option to consider for S. haematobium infection cases with drug resistance.
Availability of data and materials
The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.
Chronic Kidney Disease Epidemiology Program
Estimated glomerular filtration rate
4-variable Modification of Diet in Renal Disease
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Authors are grateful to the study communities and participants for making this research a success. We also thank Dr. Oumou Maiga-Ascofare for her efforts and hard work in coordinating this study. We are further grateful to Tony Sarfo-Acquah and Patrick Obuam for their assistance in data collection.
This study was funded by the EOD group, Kumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana.
Ethics approval and consent to participate
Ethical approval was obtained from the Committee for Human Research Publication and Ethics, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Ghana (CHRPE/AP/227/17). All participants were required to sign an informed consent. For minors below 16 years, a signed assent form from the participant and an informed consent from a parent or guardian were requirements for participation.
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Darko, S.N., Hanson, H., Twumasi-Ankrah, S. et al. Three monthly doses of 60 mg/kg praziquantel for Schistosoma haematobium infection is a safe and effective treatment regimen. BMC Infect Dis 20, 323 (2020). https://doi.org/10.1186/s12879-020-05053-z


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The interplay of tonal resonance and energetic vibrations within the realm of melodic vessels for therapeutic purposes encompasses a fascinating domain of inquiry. Profound sonic synergy intertwines with the intricate dance of restorative frequencies, encompassing a harmonious symphony of curative potential. Delving into the rich tapestry of these resonant containers unveils a vibrant amalgamation of auditory phenomena that beckons exploration.
Embarking upon the Sonic Sojourn
The juxtaposition of melodious frequencies with the intricate terrain of healing pursuits beckons a voyage into the therapeutic possibilities of melodic vessels. These intricate instruments, often referred to as singing bowls, weave a tapestry of acoustic allure, enticing the senses into a symphonic embrace that transcends the mundane.
Reverberations of Holistic Restoration
Singing bowls orchestrate reverberations that resonate deeply within the very fabric of one's being, fostering a sense of interconnectedness with the cosmic cadence. Their tonal emanations create a resonant sanctuary wherein the mind finds solace and the soul discovers renewal. This auditory embrace enkindles a dance of harmonious vibrations that permeate physical, emotional, and spiritual realms.
A Quandary of Harmony and Contrast
Intricate rhythms interplay with ephemeral crescendos, birthing a tapestry of auditory resonance that treads the fine line between harmony and contrast. The unpredictable cadence, akin to nature's own symphony, captivates the senses with a harmonious dance of perplexity and burstiness. Akin to the ebb and flow of life's myriad experiences, these melodies invite the listener to surrender to the enigma of ever-shifting tones.
Sonic Alchemy: Crafting Vibrational Elixirs
Within the delicate choreography of melodic vessels, echoes the art of sonic alchemy. The interweaving of harmonious frequencies and dissonant undertones creates an elixir of sound that resonates with the body's energy centers, or chakras. Each singing bowl becomes a conduit for vibrational medicine, offering a symphonic tonic that nourishes the soul and harmonizes the chakral tapestry.
Enigmatic Echoes of Ancestral Wisdom
Steeped in the lineage of ancient cultures, the legacy of singing bowls reverberates through the corridors of time, preserving echoes of ancestral wisdom. These vessels of sound were revered not merely as musical instruments, but as conduits to the ethereal realm. The resonance they summon is an homage to the echoes of epochs past, a testament to the profound connection between sound and spirit.
The Orchestrated Dance of Frequencies
As the gentle arc of a mallet sets the singing bowl into motion, an orchestrated dance of frequencies unfurls. The sonic canvas painted by these reverberations is a work of artistry, bearing the brushstrokes of both intention and serendipity. The complexities of each vibrational composition are akin to the multifaceted nuances of life itself, a symphony of harmonies and discords that resonate with the very essence of existence.
Transcending Sonic Dimensions
The journey through the auditory landscape of singing bowls transcends the confines of mere sound; it delves into the realms of energetic dimensions. The paradox of uniformity and diversity within each note mirrors the enigma of existence—a tapestry of paradoxes that form the very fabric of reality. As one engages with these resonant vessels, a portal to alternate perceptions and altered states of consciousness opens, inviting exploration beyond the familiar.
The Healing Odyssey Unveiled
In unraveling the narrative of singing bowls as instruments of healing, a profound odyssey of restoration is unveiled. Their resonance merges the mystical and the scientific, the intangible and the palpable, offering a holistic embrace that transcends the limitations of conventional modalities. This journey of healing and transformation is a melodic pilgrimage, where the convergence of sonic symphony and sacred vibrations guides one toward a harmonious state of being.
A Sonic Resonance Beyond
In the heart of the singing bowl's song lies a testament to the interconnectedness of all existence. Their melodies resonate as a reminder that we, too, are part of the cosmic symphony—a symphony that harmonizes and contrasts, perplexes and bursts forth, weaving the intricate tapestry of life. As we listen to the enchanting resonance of these vessels, we journey through the labyrinthine corridors of the soul, encountering the ethereal and the earthly in harmonious embrace.
Singing bowls, those melodic vessels that bridge the realms of sound and spirit, beckon us to embark on a journey of resonance and renewal. In their enigmatic harmonies, we find a source of solace and transformation—an invitation to attune our beings to the symphony of existence. With each reverberating note, we delve deeper into the intricacies of life's cadence, embracing the dance of perplexity and the artistry of burstiness that defines our very essence.

domain: literature


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Though summer officially starts on Tuesday, our summer crew has a week of work under their belts. Sergio (rising 10th grader at SciTech), TyQyan (rising 9th graders at Bishop McDevitt) and Cameron (rising junior at McDevitt)
started last Thursday and have already been a great asset to the farm. They are working about 25 hours a week, helping with all aspects of the farm–planting, weeding, harvesting, and assisting customers at our farm stands. They join an amazing group of volunteers and interns:
- Josh (full time volunteer at Joshua Group, assisting with after school tutoring, GED tutoring, Hope in Handball, food bank, and many other things; getting married in July to his lovely fiance Micalagh, fond of flowers, protector of the lettuce, and not yet allergic to poison ivy)
- Roanna (full time summer intern at the farm, recent graduate of Messiah College where she studied dietetics, farm girl from Mt. Joy, off to Bolivia for two weeks again this summer, then on to West Virginia for graduate school, the cheerful face you’ll see at the farm stand, competent Spanish speaker, and chef extraordinaire)
- Tom (Americorps intern at Joshua Group for the summer, native of Carlisle, music maker, off to Eastern College in the fall, would rather be barefoot)
- Beth (faithful volunteer, 2009 graduate of the University of Pittsburgh with majors in urban studies and sociology, builder of Joshua Farm’s chicken tractor, foster parent to seeing eye puppies, lover of great music, queen of quirky tan lines)
- Masako (faithful volunteer, rising senior at Wheaton College, native of Dillsburg, weed warrior, passionate about food access issues)
Roanna will be working with the students each Friday to prepare lunch for the farm crew. Today’s menu was Three Pea Stir Fry over Rice and Bok Choy Quiche. Nothing warms my heart like hearing teenagers ask for seconds of vegetables!


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Yes ours is the one on the right of the newly painted yellow one.... It looks like a prison with all the security bars. Previous owner was worried about burglary. Single lady staying on her own so I can understand to some extent. Anyway we bought it. Had to spend a day in the land office to do transfers. You need to turn up in person and not just go through a lawyer. Still it gone done. Transfer tax was sorted out at same time. So one minute we were sitting the land office with a bankers cheque and next minute we had no bankers cheque but were holding onto the original deeds tot he property.
Its 5 meters wide and about 17 meters long/deep from the road. Opposite side of the road is the beach. Lots of little fishing huts and small shops. I understand these are all due for relocation in next year or so to open up the beach to the general public. Essentially they are squatters but they have made a live for them selves and in a way it is a pity to see them get moved on. But there has been a lot of local public complaint about the mess and the rubbish they let and discharge into the sea.
Need less to say we will watch this development with interest. Things in Thailand have a way of happening or not as the case maybe depending on who really wants to get what done. TIT as we say. This is Thailand. So they might move on or they might stay for next 20 years. No one can say for sure....!!!!
A few doors down two town houses have been converted into a guest house. Link here. Gives you a bit of an idea about the place. Link takes you to google maps page.
I'll be doing some follow up pages as we progress. For now waiting on electricity and water connections.
CLICK THE LINK BELOW FOR GOOGLE MAP LOCATION


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ST. EUSTATIUS–On Sunday, June 25, around 1:00am the Caribbean Netherlands Police Force (KPCN) on St. Eustatius received a call that two injured persons were found in a dwelling at Blijden Road in Concordia, St. Eustatius.
On the scene, Police discovered a deceased woman and a man who was wounded. The injured man was transported to Queen Beatrix Medical Centre.
The Police have started an extensive investigation into the incident. The Police did not reveal any more details about the incident, or about the identity of the victims. The Police said no further information could be provided at that time. KPCN and the Prosecutor’s Office will provide updates as the investigation progresses, according to a statement provided by KPCN on Sunday afternoon.
The Prosecutor’s Office said Sunday evening that the injured man was arrested. He is suspected of involvement in the woman’s death.
A big crowd was near the scene of the crime during the early morning hours. The Police had the area cordoned off with tape.
Both victims are Colombian nationals. The man works on St. Eustatius with a local company. The couple were on a cruise earlier on Saturday evening and were later seen at a local establishment.
Unconfirmed reports stated that another resident who lived in the same house returned home and found the couple lying unresponsive on the floor. The person then returned to the bar near F.D. Roosevelt Airport in Concordia and informed the proprietor that there was an incident that required Police intervention.
The island was in a state of shock after the incident, as many commented that “things like these do not happen on Statia.” The last murder to occur on the island concerned Leora “Lee” May Bauer-Whitaker (75), who was murdered at her home in Fair Play on August 29, 2005.
Detectives arrived from Bonaire to investigate. They arrived on a chartered aircraft after 1:00pm.
Bron: Daily Herald

domain: law


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3 Reels (ca. 1,650 items (on three microfilm reels))
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Poems; BOOK OF WISDOM, edited by Dixon; biographical material and biography by Grant Wallace for W.P.A., 1936; catalogues, printed material, news clippings; Manifesto of California Society of Artists; letters from prominent individuals such as James D. Hart, Ansel Adams, Jacob Zeitlin, suggesting Dixon as subject for a commemorative stamp; and correspondence with "Drygulch Dick," Robert Macbeth, his father, and others.
Biographical / Historical:
Mural painter (San Francisco, Calif.)
Lent for microfilming 1974 by Edith Hamlin, wife of Maynard Dixon.
The Archives of American art does not own the original papers. Use is limited to the microfilm copy.


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Nepal is currently fighting the second war of the Corona Destruction and many Nepalis have returned home after recovering and some are in the process of recovering. Today we are presenting the experiences of two nurses who have been working in the old Baneshwor Ratnarajya School for about 45 days.
Sangina Simkhada said that she was very proud to be able to serve the patient when she came to the hospital 45 days ago. Today, she is even happier to be able to return home after this period. We have to work with high vigilance when we are all infected.
Sometimes Baba Mami would force her to tell her daughter not to leave the house even though she knew it, but since her profession is to serve the sick people , we used to come back to serve the sick by reminding them who would take care of the sick. Nurse Simran Khatiwada said that her mother used to encourage her to be blessed as much as she served.
“Sometimes when we are giving injections, patient cough at their face, but we don”t think this as a bad situation , we are doing their job,” said Simran. She said that she is still working and will continue to serve them.
The current outbreak of the coronavirus disease (COVID-19) has become a pandemic. All COVID-19-affected countries in the world are implementing containment interventions and trying their best to fight against the disease to halt the further spread of the infection and to reduce mortality.
The public health workforce and healthcare staff in clinical settings are playing a crucial role in the early detection of cases, contact tracing and treatment of patients.
The availability of personal protective equipment (PPE) and their consistent, proper use by healthcare providers and public health professionals is a crucial factor in combating any infectious disease in a crisis. The requirement of PPE has exponentially increased, as more and more countries are experiencing the COVID-19 pandemic.


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Unravel - This Way Down download mp3 album
Long Way Down is the debut studio album by British singer-songwriter Tom Odell. It was released on 24 June 2013 and serves as the follow-up to his 2012 extended play, Songs from Another Love. It serves as his first release with a major record label, and was released with Columbia. In early 2012, Odell announced that he had signed to Columbia and began recording his debut album later on in 2012.
Album · 2014 · 1 Song. The Wings That Will Never Burn Down (Charlotte ED 1) - Single. See All. Unravel (From "Tokyo Ghoul") - Single. New Anime Revolution. Unravel (SARE Remix) - Single. Tokyo Ghoul Collection - Instrumental Covers. Glassy Sky (from "Tokyo Ghoul") - Single. Don't Lose Your Way (Kill la Kill) - Single.
Unravel This - It Never Gets Easier, Already Here, I Can't Take It Anymore and 9 more tracks from this album here for free. More albums by this artist. Count: 9. Views: 0. Unravel This tracks. It Never Gets Easier.
Unravel (Tokyo Ghoul Opening Song) Vocals by TK from Ling Tosite Sigure.
Oh, can you tell me, can you tell me the way the story ends? A monster in my heart A ghost inside my chest I'm broken down, the world around us Surround my suffering You smile and laugh at me But you don't see a thing. Damaged and broken as I am I'm trying not to breathe Unraveled, I'm not unraveled by The truth I finally see, freeze
Unravel (Tokyo Ghoul OP1) digital guitar tab. Contains printable guitar tab plus an interactive, downloadable digital guitar tab file. Does not contain lyrics. Title: Unravel (Tokyo Ghoul OP1). By: Eddie van der Meer. The Arrangement Details Tab gives you detailed information about this particular arrangement of Unravel (Tokyo Ghoul OP1) - not necessarily the song. Not the arrangement you were looking for? View All Arrangements.

domain: artistic


Open the garage, unlock the door, turn on the lights, start the car, find your keys, call for help, & more, all with one handy gadget!
With OmniFob you can create your own personalized EDC solution that merges together smart tech shortcuts and your essential everyday items.
Create your own modular system to suits your everyday needs
Create your own simple IoT tasks or perform complex routines via the Keyport app to control your smart locks, garage doors, home security, smart lights, outlets, plugs and connected car – all with just one gadget in your hand!
OmniFob provides quick access to a range of frequently used smart functions - on/off, open/close, lock/unlock, arm/disarm. In addition to smart home applications, it integrates remote start and keyless entry for compatible connected vehicles. You can even control multiple vehicles with a single OmniFob (compatible with any vehicle with an aftermarket system installed).
In addition to attaching it to a traditional keychain or carrying it independently, OmniFob is compatible with a range of Keyport's modular devices - the Slide 3.0, the Pivot, and the Anywhere Pocket Clip. You can transform this finger-sized key fob from a standard keychain into your own personal life remote.
Bluetooth Locator Powered by Chipolo
A premium built-in Bluetooth locator, powered by Chipolo technology is included for an extra layer of security.
The integrated locator helps you track down your OmniFob with the Chipolo app on your phone, or you can use the smart fob to find your missing phone. The locator can also be voice-controlled through Alexa, Google Assistant, and Siri.
A Panic Button
In case of an emergency, where the OmniFob owner is unable to reach their smartphone, they can send a pre-set message and their GPS coordinates to the designated recipients with a panic quick control, as long as the fob is within the phone’s Bluetooth signal range.


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Managing reservations in a luxury hotel is like conducting a symphony. The harmony of seamless guest experiences, efficient operations, and maximized revenue all relies on a well-optimized automated reservation system. In this article, we will delve into the importance of such a system and explore strategies for optimizing its performance. So grab your baton and let’s begin!
Understanding the Importance of an Automated Reservation System
Imagine a bustling hotel lobby without a receptionist. Chaos! An automated reservation system is like your trusty concierge, streamlining the booking process for guests and ensuring a smooth operation behind the scenes.
But let’s dive deeper into the world of automated reservation systems and explore why they are so crucial for the success of any hotel.
Streamlining the Booking Process for Guests
Guests are the heart and soul of any hotel, and their journey should be a delight from the moment they decide to make a reservation. A well-optimized automated system enables them to effortlessly browse room availability, select their preferences, and book at their convenience.
Imagine a guest, sitting comfortably on their couch, browsing through the hotel’s website. With just a few clicks, they can explore different room types, view detailed descriptions, and even check out high-resolution images of the rooms. The automated reservation system provides them with real-time information on availability, allowing them to make an informed decision.
Once the guest selects their desired room, the system takes them through a seamless booking process. It prompts them to enter their personal details, such as name, contact information, and any special requests they may have. The system then securely processes their payment, providing a sense of security and convenience.
Enhancing Efficiency and Accuracy in Reservation Management
Just as a conductor keeps each musician in sync, an optimized reservation system orchestrates the coordination of room assignments, availability updates, and payment processing. By reducing manual errors and ensuring accuracy, it empowers your staff to focus on providing exceptional service.
Behind the scenes, the automated reservation system acts as a central hub, seamlessly integrating with other hotel systems. It communicates with the property management system, updating room availability in real-time. This ensures that guests can only book rooms that are actually available, preventing any disappointments or overbookings.
Moreover, the system assigns rooms to guests based on their preferences and any special requests they may have made during the booking process. This level of personalization enhances the guest experience and leaves a lasting impression.
Maximizing Revenue through Effective Reservation System Optimization
Picture a hotel filled to the brim, with every room singing a sweet melody of profitability. An optimized reservation system not only increases occupancy rates but also optimizes pricing strategies, implements special offers, and manages room inventory effectively.
By analyzing historical data and market trends, the automated reservation system can suggest dynamic pricing strategies. It can adjust room rates based on demand, ensuring that the hotel maximizes revenue during peak periods and attracts guests during slower seasons.
Additionally, the system can implement special offers and promotions, enticing potential guests to book directly through the hotel’s website. This reduces reliance on third-party booking platforms and increases direct bookings, resulting in higher profit margins.
Furthermore, the reservation system effectively manages room inventory. It provides detailed reports and analytics, allowing hotel managers to make informed decisions about room allocations, renovations, and future expansion plans.
In conclusion, an automated reservation system is not just a tool for streamlining the booking process. It is a powerful asset that enhances the guest experience, improves operational efficiency, and maximizes revenue for hotels. Embracing this technology is essential for staying competitive in today’s fast-paced hospitality industry.
Assessing the Current Reservation System in Your Luxury Hotel
Now that we understand the importance of an automated reservation system, let’s take a critical look at your hotel’s current system. Identifying its strengths and weaknesses is the first step towards optimization.
When assessing the current reservation system in your luxury hotel, it is essential to consider various factors that contribute to its overall performance. One crucial aspect to evaluate is the system’s reliability. A reliable reservation system ensures that bookings are accurately recorded and maintained, minimizing the risk of double bookings or errors in guest information. Additionally, a dependable system guarantees that reservations are seamlessly communicated to the relevant departments within the hotel, streamlining the overall operations.
Another key factor to consider is the ease of use of the reservation system. A user-friendly interface allows hotel staff to efficiently navigate through the system, making bookings and managing guest information effortlessly. A well-designed system should have intuitive features and clear instructions, reducing the learning curve for new employees and ensuring a smooth workflow.
Reporting capabilities are also crucial when assessing the current reservation system. A robust reporting system provides valuable insights into occupancy rates, revenue trends, and guest preferences. By analyzing these reports, hotel management can make informed decisions regarding pricing strategies, marketing campaigns, and resource allocation.
Furthermore, evaluating the integration of the reservation system with other hotel operations is essential. A seamless integration with front desk management allows for efficient check-in and check-out processes, ensuring a positive first and last impression for guests. Integration with housekeeping facilitates effective room assignment and maintenance, ensuring that rooms are ready for guests upon arrival. Additionally, integration with customer relationship management (CRM) systems enables personalized guest interactions and targeted marketing efforts, enhancing the overall guest experience.
Identifying Strengths and Weaknesses of the Existing System
Like a skilled critic, evaluate how well your current system performs in terms of reliability, ease of use, reporting capabilities, and integration with other hotel operations. Analyze user feedback and reviews, both positive and negative, to gain valuable insights for improvement.
By conducting a thorough evaluation of the existing reservation system, you can identify its strengths and weaknesses. Recognizing the system’s strengths allows you to leverage and build upon them, enhancing the overall guest experience. On the other hand, identifying weaknesses provides an opportunity for improvement, ensuring that the reservation system aligns with the high standards of your luxury hotel.
Analyzing Guest Feedback and Reviews for Improvement Opportunities
Famous hospitality expert, Laura Buusmann, once said, “Guests are the ultimate judges of your hotel’s performance.” Don’t just listen to the applause, but rather analyze guest feedback and online reviews to understand pain points, bottlenecks, and areas needing improvement within your reservation system.
Guest feedback and online reviews offer valuable insights into the guest experience and can highlight areas for improvement within the reservation system. By analyzing this feedback, you can identify common issues faced by guests, such as difficulties in making reservations, delays in confirmation, or inaccuracies in booking details. Addressing these pain points can significantly enhance the overall guest satisfaction and loyalty.
Moreover, guest feedback can provide valuable suggestions for system enhancements. Guests may offer ideas for additional features or improvements that can streamline the reservation process and elevate the overall user experience. By actively listening to guest feedback and incorporating their suggestions, you demonstrate a commitment to continuous improvement and guest-centricity.
Evaluating the System’s Integration with Other Hotel Operations
In today’s interconnected world, seamless integration is the key to success. Evaluate how well your reservation system integrates with other hotel operations like front desk management, housekeeping, and customer relationship management. This alignment ensures a harmonious guest experience throughout their stay.
The integration of the reservation system with other hotel operations is crucial for delivering a seamless guest experience. A well-integrated system enables real-time communication between departments, ensuring that information is shared accurately and efficiently. For example, when a guest checks in, the reservation system should automatically update the front desk, housekeeping, and CRM systems, allowing for a coordinated and personalized guest experience.
Furthermore, integration with the front desk management system enables efficient handling of guest requests and preferences. For instance, if a guest requests a specific room type or amenities, the reservation system should seamlessly communicate this information to the front desk, ensuring that the guest’s expectations are met upon arrival.
Overall, a well-integrated reservation system enhances operational efficiency, minimizes errors, and improves guest satisfaction. By evaluating the current system’s integration with other hotel operations, you can identify any gaps or areas for improvement, ensuring a seamless and exceptional guest experience from reservation to check-out.
Implementing Best Practices for Optimizing the Reservation System
With a thorough assessment complete, it’s time to fine-tune your reservation system using tried-and-true strategies. Follow these practices to achieve a symphony of efficiency and guest satisfaction.
Implementing best practices for optimizing the reservation system is crucial for any hotel looking to stay ahead in the highly competitive hospitality industry. By embracing innovative technology, customizing the system to meet the unique needs of your hotel, and ensuring seamless integration with online booking platforms, you can elevate your hotel’s performance to new heights.
Utilizing Advanced Technology and Software Solutions
Renowned management guru, Peter Drucker, emphasized the power of technology in increasing productivity. Embrace cutting-edge reservation management software and tools to automate tasks, improve reporting accuracy, and generate actionable insights. Think of it as a sophisticated instrument that elevates your hotel’s performance.
By utilizing advanced technology and software solutions, you can streamline your reservation system and enhance the overall guest experience. These tools offer features such as real-time availability updates, automated confirmation emails, and integrated payment gateways, making the booking process seamless and efficient for both guests and hotel staff.
Additionally, advanced technology can help you gather valuable data and analytics, allowing you to make data-driven decisions to optimize your reservation system further. By analyzing booking patterns, guest preferences, and market trends, you can identify opportunities for improvement and implement strategies to maximize revenue and guest satisfaction.
Customizing the System to Meet the Unique Needs of Your Hotel
Just as a maestro tweaks a composition to suit the acoustics of a concert hall, customize your reservation system to fit the unique needs of your luxury hotel. Tailor the user interface, pricing configurations, and booking rules to match your brand identity and service offerings.
Customization plays a vital role in creating a seamless and personalized booking experience for your guests. By incorporating your hotel’s branding elements into the reservation system, such as logos, color schemes, and fonts, you can create a cohesive and immersive online presence that aligns with your overall brand image.
Furthermore, customizing the pricing configurations and booking rules allows you to implement revenue management strategies effectively. You can set dynamic pricing based on demand, seasonality, and other factors, ensuring optimal revenue generation while still providing value to your guests.
Ensuring Seamless Integration with Online Booking Platforms
In the digital era, online presence is paramount. Ensure your reservation system seamlessly integrates with popular online booking platforms to maximize exposure, reach potential guests, and capture direct bookings. It’s like having a front-row seat to increased revenue!
Integrating your reservation system with online booking platforms such as Expedia, Booking.com, and Airbnb opens up a world of opportunities for your hotel. These platforms have a vast user base actively searching for accommodations, and by being present on them, you can expand your reach and attract a wider audience.
Seamless integration allows for real-time synchronization of availability and rates, ensuring that your inventory is up to date across all platforms. This eliminates the risk of overbooking and provides a hassle-free booking experience for guests.
Moreover, integrating with online booking platforms enables you to leverage their marketing and promotional capabilities. By optimizing your listings, utilizing featured placements, and offering exclusive deals, you can increase your visibility and stand out from the competition.
Implementing best practices for optimizing the reservation system is an ongoing process. Continuously monitor and evaluate the performance of your system, gather feedback from guests, and stay updated with the latest industry trends to stay ahead of the curve. By doing so, you can ensure that your reservation system remains efficient, guest-centric, and contributes to the overall success of your hotel.
Enhancing User Experience and Guest Satisfaction
Every hotel aspires to strike a chord with its guests, leaving them with a memorable symphony of excellence. Let’s explore ways to enhance user experience and create a harmonious atmosphere of guest satisfaction.
Simplifying the Reservation Process for Guests
Legendary hotelier, Bill Marriott once said, “Take good care of your employees, and they’ll take good care of your guests.” Simplify the reservation process by offering user-friendly interfaces, intuitive navigation, and clear instructions. By doing so, you empower your guests to make bookings effortlessly, ensuring a virtuoso performance of guest satisfaction.
Offering Personalization and Customization Options
Today’s guests expect hotels to compose personalized experiences tailored to their preferences. Implement a reservation system that allows guests to select room types, amenities, and special requests, transforming their stay into a unique concerto of comfort and delight.
Providing Real-Time Availability and Instant Confirmation
As the tempo of life accelerates, guests crave instant gratification. Equip your reservation system with real-time availability updates and provide instant confirmation of reservations. Let your guests hear the sweet melody of assurance as they secure their stay hassle-free.
Like a finely tuned orchestra, an optimized automated reservation system sets the stage for a symphony of success in a luxury hotel. By understanding its significance, assessing the current system, implementing best practices, and enhancing the guest experience, you can create an unforgettable masterpiece that harmonizes efficiency, revenue, and satisfaction. So, maestro, let the optimization begin!


ICYMI: “Trump Remains the Key to Republican Election Victories” - 06/01/21
Tronic last edited by Tronic
ICYMI: “Trump Remains the Key to Republican Election Victories”
Read the full article by Christian Whiton for the National Interest here.
Trump Remains the Key to Republican Election Victories
Forget the naysayers. The GOP is on the march to success.
by Christian Whiton
Forget the naysayers in the media, the NeverTrumpers, and the RINOs. Despite the best efforts of some of its once-leading figures to unlearn the lessons taught by former President Donald Trump, the Republican Party is in great shape going into midterm elections next year and in setting the stage for the 2024 presidential election. Staying the course will propel it to victory.
It is customary self-indulgence after a change in power in Washington to predict that the other party is not only defeated, but likely to go extinct. This past election was no exception. In March, President Joe Biden said he had no idea if there would even be a Republican Party in 2024. Former President George W. Bush said Republicans “want to be extinct.” The facts say otherwise. Setting aside the furiously contested presidential election result, Republicans gained seats in the House in 2020 and will likely build on that performance next year, taking control of one or both houses of Congress.


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Joshua Coffman missing in Chattanooga, needs medication
CHATTANOOGA, Tenn. —
Chattanooga Police and his family need your help locating 25-year-old Joshua Coffman.
Police say Coffman was last heard from on June 1st, 2017. He had been staying at the Chattanooga Rescue Mission.
Police say it is very unusual that he has not been in contact with family members.
He has health issues that may cause him to be a danger to himself, if he doesn't take his medication, which he reportedly doesn't currently have.
If you have seen Coffman, please contact Chattanooga Police at 423-698-2525.


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Comic-Con: Cast and Executive Producers Bring the First Trailer for The Shannara Chronicles
" look at this show and I think everything about it is right."
It goes without saying that MTV is not the network many of us remember from our childhoods. They've branched out with their programming, and The Shannara Chronicles is taking the network in a new direction. The adaptation of Terry Brooks's The Elfstones of Shannara means diving into a world of fantasy – one with elves, magic, etc. The series follows a group of three elves who have to fight against demons as a magical tree that kept the demons away starts to die. Cast members Poppy Drayton (Amberle), Ivana Baquero (Eretria), Austin Butler (Wil), Manu Bennett (Allanon), and John Rhys-Davies (Eventine) and executive producers Al Gough, Miles Millar, and Brooks brought the first trailer for the upcoming drama to Comic-Con and shared a little information about the characters and development process.
Brooks said he's been approached about adapting The Shannara Chronicles before, but it's always been talked about for the big screen. The books are so sweeping though that it would be tricky to capture them in just a few hours. They've been working seriously on the TV series for a couple of years. Brooks said, "I've been fairly picky about the people I work with. The combination [here] is right -- all the parts of the organization seemed like a really good fit." He continued, "A TV series seems very much the right choice." Gough agreed, explaining the books are too broad and expansive, "For us, it was the perfect way to tell this story, to have this 10-episode series."
If you're a fan of the books and worried about how hands-on Brooks is in the process, don't be concerned. He's very much involved because as he said, he has a trust established with the readers and wants them to know the show is in good hands. Gough is right there with him and said, "It's crucial to have the author involved in this." Millar did add that the show still manages to be it's own thing while remaining faithful to the spirit of the book and the characters.
As you watch the first trailer, you'll probably note similarities between the sweeping locales and those of Lord of the Rings. Like those movies and series such as Xena, The Shannara Chronicles is filmed in New Zealand. Gough joked that, "One of the great things about being in New Zealand is knowing what works and what doesn't work" when it comes to getting elf ears right. Bennett mentioned New Zealand is a place where fantasy series are done like nowhere else in the world because of the long history practitioners have there in working in the genre. The location looks to be as much as character as the cast and will play into the journey and traveling aspect of the series, and the trailer conveys a sense of adventure, intensity, danger, and fun.
The cast all seem quite excited to be part of the world and discussed their three weeks of intensive training involve sword fighting and horseback riding -- Drayton said, "It was intense but fun." Rhys-Davies and Bennett were especially complimentary towards Butler, and actually, Rhys-Davis was enthusiastic in general. He had high praise for the series and said, "You get the smell of the great ones... there's something about this on that's going to make it into an astonishingly important series... I look at this show and I think everything about it is right."
Before the panel ended, Gough and Brooks teased at the possibility of an anthology to tell future stories within The Shannara Chronicles. In response to an audience question on the subject, Gough said, "That's an excellent question, but we're not going to reveal that yet."
The Shannara Chronicles will premiere on MTV in January 2016.
Amy Ratcliffe is a writer for IGN TV. You can follow her on on Twitter at @Amy_Geek and IGN at alratcliffe.

domain: entertainment