By Kirk Makin, Globe and Mail, February 14, 2012
An Ontario Superior Court judge has refused to impose a mandatory three-year sentence on a man caught with a loaded handgun, putting the courts on a collision course with the federal government’s belief in fixed sentences that provide judges with little discretion.
In a decision Monday, Madam Justice Anne Molloy added fuel to a rising sense of judicial anger over mandatory minimum sentences by striking down the compulsory term as cruel and unusual punishment
Instead, she sentenced the defendant, Leroy Smickle, to a year of house arrest. Judge Molloy concluded that Mr. Smickle, a 30-year-old Toronto man with no criminal record, had merely been showing off by striking a “cool” pose over the Internet when police happened to burst into an apartment on March 9, 2009, in search of another man.
The government has adamantly held to the view that mandatory minimums are a necessary restraint on judges who might impose inappropriately lenient sentences for certain offences. That is part of a larger tough-on-crime agenda that includes everything from harsher prison sentences to restricting parole and pardons.
Several months ago, in another major challenge in Ontario Superior Court, a similar sentencing provision was upheld in a firearms case, Regina v. Nur. That, combined with the Smickle ruling, could well result in a high-profile appeal that goes all the way to the Supreme Court of Canada.
Critics argue that a one-size-fits-all sentencing policy inevitably leads to unfair results. In her ruling Monday, Judge Molloy added her voice to those criticisms by saying there are an endless number of scenarios where a fixed sentence would be so cruel as to violate the Charter of Rights.
She said the federal goal of deterring crime is understandable and effective – up to a point. The problem is that individuals can be unfairly crushed along the way, she said. The judge cited Mr. Smickle as just such a case – a peaceable man with solid career prospects whose life would likely have been ruined by the imposition of a three-year penitentiary sentence.
Imagine a Justice willing to put the federal government's "one-size-fits-all sentencing" on trial!
This is a day when Canadians can thank Justice Molloy for her insight, her courage and her willingness to make a "fair" judicial decision rather than destroy the life of an individual. And of course, along with other similar decisions, this one will likely be included in an appeal to the Supreme Court where the current government's "tough-on-crime" legislation will be facing the Charter of Rights and Freedoms and the justices will decide.
Trying to overturn what is essentially a fair judicial system, including fair and balanced judgements from fair and balanced judges might prove more difficult than this government would have thought, if this government did any thinking. Playing politics with the lives of Canadians, for their own politicial purposes (getting and assuring themselves of getting the votes of their neo-con base in the next election!!) is simply not the job of the federal government.
It is the people like Justice Anne Molloy who are protecting Canadians by retaining the respect, credibility and fairness that is at the core of the Canadian justice system, and not the current federal government playing "bully to the nation" in a guise of assumed and pontifical power that is neither required nor respectful of the tradition of our judicial system.
Only if and when this government brings real human beings into its consideration, on all files, will it begin to earn the respect of the Canadian people. It is people for whom they are responsible, for whom they are charged with governing, for whom they are charged with protecting And one of those people is Justice Anne Molloy whose discretion and perspective and independence is essential to the maintenance of law and order. The government is not only governing for some abstract concept of a corporation or a stock exchange, or a class of investors whose identity is unknown unless and until they write that "manna" cheque to the conservative party, to fill their coffers to overflowing in time for the next election most of whom believe that the Liberal governments of the recent past were "too soft on crime."
Let's all have a drink in honour of Justice Anne Molloy!
Put that decision in your pipe and smoke it, Mr. Harper and Mr. Nicholson!


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Weakening German Consumer Confidence Fails to Weigh Down Euro (EUR) Today, Pound (GBP) Remains Soft on UK GDP Shortfall
Despite the German Consumer Confidence Survey for November showing the expected slump in optimism, falling from 9.6 to 9.4, the Pound Sterling to Euro (GBP/EUR) exchange rate is on a downtrend on Wednesday morning. Investor sentiment towards the Pound (GBP) has remained weak overnight after yesterday’s disappointing UK GDP report.
The outlook of the Pound (GBP) has softened today after the third quarter UK GDP printed at a weaker level than forecast, throwing doubt on the odds of a nearer-term interest rate rise from the Bank of England (BoE).
Euro (EUR) Exchange Rate Bearish in spite of Improved IFO Business Sentiment after ECB Dovishness
Demand for the Euro (EUR) remained weak on Monday in spite of a relatively strong printing on the German IFO Business Sentiment Surveys. Although both the Business Climate and Expectations indexes showed unexpected increases, these were counterbalanced by a weaker showing on the Current Assessment figure, which slipped from 114 to 112.6 in October. Concerns over the Volkswagen emissions scandal appear to be seen as relatively fleeting, even if the crisis has dealt a significant blow to confidence in the Eurozone’s powerhouse economy in the short-term. Nevertheless the dovishness of European Central Bank (ECB) President Mario Draghi after last week’s Rate Decision has continued to weigh on the appeal of the common currency.
While the UK’s BBA Loans for House Purchase report clocked in at a weaker level than expected, defying expectations for a minor uptick to instead retreat to 44,489, this was ultimately not enough to trigger a particular downtrend for the Pound (GBP). This signal of slowdown within the domestic housing industry, however, has once again raised suggestions that the Bank of England (BoE) may not opt to move on interest rates until at least the second quarter of 2016.
Pound (GBP) Currency News: UK GDP Falls Short of Forecast Today as Economic Growth Weakens
Investors have been taking a relatively cautious approach to Sterling on Tuesday morning in advance of the third quarter UK GDP. News was not positive for the Pound, though, as economic growth was revealed to have slowed further than expected in the third quarter from 0.7% to 0.5%. With the year-on-year figure also unexpectedly slipping, from 2.4% to 2.3%, this dealt a blow to the odds of a nearer-term interest rate increase from the BoE. As a result sentiment quickly turned bearish, pushing the GBP/EUR exchange rate into a downtrend.
GBP/EUR Exchange Rate Forecast: Euro Could Resume Downtrend with Upcoming German Data
The single currency could shed further value in the later week, with tomorrow’s German Consumer Confidence Survey and Thursday’s German Unemployment Change both expected to weaken. While the domestic Unemployment Rate is forecast to remain steady at 6.4% this is unlikely to provide enough positive stimulus to bolster the Euro from its bearish trend.
Thursday will also see the publication of further UK data, including Nationwide House Prices and Mortgage Approvals figures. As these are expected to show relative robustness within the domestic housing market this could offer a rallying point for the Pound, although it is unlikely to entirely eclipse the dovish impact of today’s disappointing GDP reading.
Current GBP, EUR Exchange Rates
At time of writing, the Pound Sterling to Euro (GBP/EUR) exchange rate was shedding value in the range of 1.3876, while the Euro to Pound Sterling (EUR/GBP) pairing climbed in the region of 0.7206.

domain: finance


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Sudan’s minister of defense, Lt Gen Jamaleldin Omar, has died of a heart attack in South Sudan.
Omar was in South Sudan’s capital of Juba, taking part in peace talks between his country’s transitional government and rebel groups, the officials said. He attended meetings that stretched into late Tuesday and died overnight. There was no further information.
The officials spoke on condition of anonymity because they were not authorized to talk to the media.
Omar was a member of Sudan’s Sovereign Council, which took power last year under a 39-month power-sharing deal between the country’s military and the pro-democracy movement that led the uprising against former autocratic President Omar al-Bashir.

domain: news


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Cherry Crest Adventure Farm
Join Cherry Crest Adventure Farm on Saturdays from May 23-June 27 for over 30 popular Farm Fun activities and rides, including a Hay Chute Slide, Giant Jump Pillows, Farm Tour Wagon, and more.
Wizard of Oz at the Fulton Theatre
With complicated flying, enormous puppetry, high-tech video, stage hydraulics, and a cast of over 50 performers, this show will be the biggest event of the season. On stage June 2–July 12.
Enjoy Springtime Outdoors
Experience Lancaster's natural beauty with biking, hiking, covered bridge tours, hot air balloon rides, and many more outdoor activities. Enjoy our landscape while taking in a breath of fresh air!

domain: travel


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Five members of the senior leadership of the opposition submitted materials of their tapped conversations today to the Public Prosecutor on, as it claims, a directive of the Government, and as an extension of the criminal charges for unauthorized wiretapping which SDSM filed several weeks ago.
Professor and candidate for president of SDSM in the last presidential election, Stevo Pendarovski, expressed hope that the evidence submitted by him and NSDP leader Tito Petkovski, vice president of SDSM Radmila Sekerinska, Mayor of Municipality of Centar and recent LDP leader Andrej Zhernovski and SDSM Secretary Oliver Spasovski, will not suffer the fate of the previous criminal charges, for which so far “nobody has an idea what is happens to it.”
– Because we all legalists, we want to believe that the institutions in the country will finally dare and act upon criminal charges for a massive crime against human rights, tapping of thousands and thousands of citizens of this country, without any reason. We have no faith in the people who currently run this institution (prosecution), but we believe that all the rest, among who, there are professionals, experts, virtuous people, this time will not be quiet and, in the interest of our common better future, will act upon the charges – stated Pendarovski.
According to Pendarovski, illegal tapping was misused by the Government for political purposes.
– The purpose for which they tapped us is to find out our political strategies and intentions. Otherwise, you know when somebody is eavesdropped? When there is reasonable doubt that we are criminals or are a criminal organization. As you know, none of us has ever been involved in drug or arms trafficking, or was part of a mafia organization. There is no basis me or my colleagues to be tapped. The only motivation was political – to gain some advantage for elections before and after them – said Pendarovski.

domain: politics


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A massive stunner of a ceiling fixture which is perfect as an entryway chandelier to greet guests. This enticing, intricate chandelier features exquisite, chain-like Clear Glass Hoops that are interlocked and aligned into four linear arrays suspended from the Mirror Polished Stainless Steel canopy above. The Lucy Southland Flushmount is included in our American made, American designed Southland Lighting Collection. Manufactured in Yorkville, NY. UL and cUL listed for dry and damp locations. This chandelier is featured in the Southland Casino in West Memphis, Arkansas.
Call 800.222.4009 For Pricing Details!
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domain: artistic


text:
«« Index »»
We are constantly thinking of the after. For me, I’m constantly thinking of when life will start after school ends. After my PhD is done, after I’ve moved out of my mother’s house, after I find a husband…But every now and then, I need to stop, take a breath, take a look around, because life is happening now.
For the contributors of this issue, the after is everywhere. The afterlife, the afternoon, the fun we have after the work is done. After loss, after love, a reconciliation after years of separation. I hope reading these pieces will make you think of your after, but I hope they also make you think of your now.
This issue of SWAMP is kind of like my first baby – I came on board as Editor-in-Chief after the lovely Annika Herb stepped down, and I have enjoyed the process immensely! My name is Nicole Shipley, and I am a current third-year PhD student at the University of Newcastle. I have been working on SWAMP as an editor since Issue 16, and taking over the reins as Editor-in-Chief has been a welcome task, both for the chance to read and critique more and more fantastic pieces of creative work, and the ability to procrastinate and still tell myself I’m working! Thank you, Annika, for trusting me with the editorial reins of this wonderful publication, and for answering all of my frantic, last-minute questions!
I want to thank all of our contributors of the issue, for writing such varied and interesting short stories and poems and sharing them with us. The best part of this role is getting to read each piece of work and wonder about the inspiration behind them. Some, as you’ll see, are shaped by strong feelings of love, loss, of family and friends, and of adventure. I hope they make you feel what I felt while reading them – moved, gladdened, and inspired!
I also want to thank the editors for this issue: we have Ella Rusak, from the University of Newcastle, who has taken on the role of Head Poetry editor, and managed to fulfil that role despite a bout of pneumonia! Shannon Todd, also from the University of Newcastle, and Fernanda Dahlstrom from Deakin University, made up the rest of the editorial board for poetry. Liz Chandler, from Massey University, and Rachel Watts, from Curtin University, joined me on the editorial board for the prose pieces. Thank you all for your hard work! Finally, thank you Peter Bower, for continuing to put this publication together, so that writers from all over have a safe place to express their thoughts, their feelings, and get their writing read.
While I was putting this issue together, I received an email from a teacher in New Zealand, who had come across a poem in an earlier issue and loved it so much, she wanted to teach it to her students. It made me think of the paradox we have of constantly worrying about the after while we try to live in the now, as well as what a fabulous space SWAMP is. It’s a space where we can come together – as authors, editors, and readers – and share thoughts and feelings and experiences. My favourite part of reading is that moment where you read something and think, Wow, you felt/did/wanted that too? I thought I was alone.
In saying that, the theme for Issue 20 is “Space”. Whether that be the spaces between, safe spaces, dangerous spaces, or the space of solar systems and galaxies, I want you to write about what space means to you, and then share it with us for Issue 20! Submissions are now open and will close 28th February!
- After Vegemite, Love, by Amy Leigh Wicks
- Afterword, by Amy Leigh Wicks
- Tuesday in Plimmerton, by Amy Leigh Wicks
- After Betty Davis, by Angie Spoto
- I Have Loved a Woman, by Evyenia Sisovitis
- Laceracija, by Evyenia Sisovitis
- They Keep the Curtains Closed, by Margaret Moores
- Screening, by Margaret Moores
- Sinking, by Margaret Moores
- Broken Twigs, by Paula King
- The Waiting Place, by Mikaela Nyman
- Bones of Contention, by M.T. O’Byrne
- Snow in the Desert, by Nicky Gluch
Published: 9 November, 2016.
Editorial Team: Nicole Shipley, Ella Rusak, Shannon Todd, Fernanda Dahlstrom, Liz Chandler, Rachel Watts, Keri Glastonbury (Editorial Advisor).

domain: literature


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In Georgia, Republican Senator David Perdue has traded stocks, bonds and mutual funds nearly 2,600 times over the past six years — often in companies within his Senate committees’ oversight. That’s according to The New York Times, which reports Perdue has been the Senate’s most prolific stock trader by far, sometimes reporting 20 or more transactions in a single day. Perdue faces Democratic challenger Jon Ossoff in a January 5 runoff election in Georgia that will determine the balance of power in the Senate.
Georgia Sen. David Perdue Traded 2,600 Stocks in One Term
HeadlineDec 04, 2020


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Just a quick follow up on an education story I first wrote about in my original "School Daze" post:
Last year, the local school superintendent fired an elementary school teacher after repeated incidents of being under the influence of alcohol during the school day, reports of driving under the influence with children in the vehicle, and repeated arrests for domestic assault and battery with alcohol involved. To many peoples' surprise, an arbitrator ruled that she was fired unfairly, a ruling upheld by a RI Superior Court judge.
So, after all that, you'd think that the teacher might have realized she needed help and made some changes for the better, right?
To quote Bruce Willis in Die Hard..."Sorry, Hans, wrong guess!"
On Monday morning, one month after being reinstated, the teacher at the center of this story was arrested by Bristol police for suspicion of drunk driving on her way to school! Of course, it's only "for suspicion" as she refused a field sobriety test (her legal right in RI) after witnesses reported erratic driving and police observed her swerving back and forth along the road.
I sincerely hope that this woman gets help and treatment for her own sake, the sake of the kids who were put into her charge, and for the sake of other people on the road (like me...I drive right past where she was arrested every day on the way to work). And while I'm a firm believer in the concept of innocent until proven guilty, it is a relief to know that the superintendent has suspended her while the allegations are being investigated. Now we'll just see if the suspension actually sticks.

domain: sociology


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[Bumped up for visibility.]
* From the Chicago Tribune’s endorsement of Republican Jim Edgar over Democrat Neil Hartigan in 1990 and Edgar’s support for making the “temporary” income tax hike permanent and Hartigan’s opposition…
It`s too bad that the public debate in this race has focused almost exclusively on taxes, and that Hartigan has played to anti-tax forces that believe they can elect Walt Disney and spend four years in Fantasia.
When Hartigan announced his proposals to find $573 million next year by slashing budgets, levying a new business tax and collecting heretofore lost revenues, they fell in the realm of safe, unrealistic, pre-election rhetoric. If he wanted to try to cut the budget, more power to him. When he came up short of expectations, the only damage would be to the psyche of Illinois voters who would have been fooled about the state`s fiscal condition in three consecutive campaigns.
But Hartigan saw that the anti-tax message moved polls in his direction. He decided to embrace the anti-tax fever even if it meant boxing himself in as governor. He announced that he would veto any attempt to continue the current 20 percent surcharge on state income taxes, even the portion that gives $370 million to the state`s struggling schools and universities. He would find the money for education in dramatic budget cuts and revenue increases that, so far, are nothing more than dreams on paper.
That was unrealistic and irresponsible. He is counting on a natural growth in existing taxes that, in view of current economic conditions, is too optimistic by at least $100 million. His proposal to slap a new sales tax on industries that expand, modernize or relocate in Illinois would be risky in good economic times; today, it`s outlandish.
And by taking so much state money away from local taxing bodies, he`s inviting increases in property taxes-a far more unpopular, inequitable way to raise money than the income tax he wants to cut.
If he fails, if his plans fall far short of his promises, either the schools won`t get the money or the state will go into debt. Or Hartigan will have to ask for higher taxes. Voters will scream and lawmakers who remember his campaign will just say no.
Those were the days, eh?
Substitute “Rauner” for “Hartigan” and they could’ve written the exact same editorial today… If they were still unwilling to live in a fiscal and economic “Fantasia,” that is.


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Dr. Susan Love'S Menopause And Hormone Book: Making Informed Choices
Attention: For textbook, access codes and supplements are not guaranteed with used items.
Arrives in 3-7 Business Days
In the first edition of this important bestselling book, praised by Newsday as the bible for a whole generation of menopausal women, renowned physician and pioneering womens health advocate Dr. Susan Love warned about the potential dangers of the long-term prescription of hormone replacement therapy. Her insightful words of caution have been backed up by the stunning results of the recent studies on hormone replacement.
In this revised edition, Dr. Love offers a remarkably clear set of guidelines as to what the studies have shown about the risks regarding heart disease, breast cancer, stroke, and other conditions, and what effect hormone therapy has on osteoporosis. She offers definitive expert advice about whether or not to go on hormone replacement therapy and, if so, for how long, as well as how to taper off hormones; and she introduces the alternative methods for treating the symptoms of menopause.
Dr. Love stresses that menopause is not a disease that needs to be curedit is a natural life stage, and every woman ought to choose her own mix of options for coping with symptoms. A questionnaire about your own health history and life preferences helps you develop a program that will best fit your unique needs. With clarity and compassion, she walks you through every option for both the short and the long term, including:
lifestyle changes (diet, exercise, and stress management)
alternative therapies (including herbs and homeopathic remedies)
available medications other than hormones
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How To Build Model Railroad Benchwork, Second Edition (Model Railroader)

domain: library


text:
Keeping secrets ruined her life. But the truth might just kill her.
Piper Woods can’t wait for the purgatory of senior year to end. She skirts the fringes of high school like a pro until the morning she finds a notebook with mutilated photographs and a list of student sins. She’s sure the book is too gruesome to be true, until pretty, popular Stella dies after a sex-tape goes viral. Everyone’s sure it’s suicide, but Piper remembers Stella’s name from the book and begins to suspect something much worse.
Drowning in secrets she doesn’t want to keep, Piper’s fears are confirmed when she receives an anonymous text message daring her to make things right. All she needs to do is choose a name, the name of someone who deserves to be punished…
I received a free copy of this book via netaglley in exchange for an honest review.
I practically read this book in one sitting. I love books like this. Full of drama, suspense and secrets. I just want to say I am in love. Strangely Tate was my favourite character.
Piper was a great main character, she told her side of the story very well. I liked how she more and more observant as the story went on. Gave us lots of suspects that left me guessing until the very end. I suspected half of the student body and even some of the staff.
What I loved most was the growth of Piper, she grew from a kid who was sure she knew right from wrong and wanted a kind of vigilante justice. To a woman who knew everything was not black and white and that she had no-right to decide who was guilty or not.
Although I did suspect the guilty party at some point I really did not have much of a clue. I was shocked to find out who it was. Not what I expected.
There was one question that was not answered for me. What happened to Stella, was it an accident or not?
5 out of 5 stars
It has been voted on If List here is the link if you are interested in seeing it. http://iflist.com/gonetoofar#


Demonstration outside Chinese Consulate-General, Sydney
The Australian Government takes very seriously its obligations to protect the safety and dignity of foreign diplomatic and consular missions and condemns all forms of violent protest.
On 22 July a demonstration was held outside the Chinese Consulate-General in Sydney. Protestors entered the grounds of the Consulate. Police contained the situation quickly, removed the protestors and made arrests.
Australian authorities are investigating the incident in close consultation with the Chinese Consulate-General.


Temperature and process controllers are generally divided into one or two categories: single-loop and multi-loop.
When should I use a multi-loop controller?
If you have more than one control loop in a single system, then you can use a multi-loop controller. In simple terms, it can be considered that a multi-loop controller can contain multiple temperature controllers in a single instrument.
Typical use and benefits
Multi-loop controllers are usually mounted at the back of the panel, unlike single-loop controllers that are often mounted in the front. Controllers are usually programmed using a proprietary software program on a PC that downloads the settings to the multi-loop temperature controller using communication.
Using a multi-loop controller rather than multiple single-loop controllers can have many benefits. Installation costs can be reduced due to the common connection point, which limits the number of cables and reduces panel cuts. Another advantage is that the controllers can be changed without stopping the system. This process, known as hot swapping, significantly reduces the downtime of the machine.


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Cut it Out! Axe Throwing Championships 2015
Weekend of 22nd August 2015
150 world-class knife and axe throwers from all over the UK, Europe, and USA will come together for the 15th World Championship Big Throwers Meeting later this month.
The exhilarating Eurothrowers meeting, hosted by KATTA (Knife, Axe, Tomhawk Throwing Association) is being held in the UK for the very first time this year.
Earnshaws Fencing Centres are thrilled to be sponsoring the event, and will be providing over 100 targets that will be used by skilled knife and axe throwers.
The Duel Cup, otherwise known as pairwise throwing, is one of the most popular competitions taking place at the event. After a signal, competitors have to stick their knives into the target before their opponent does – only the winner goes on to the next round.
Since the athletic level has increased over the years, it is no longer feasible for human judges to tell who was faster. So, for the first time, electronic measurement devices will deployed – registering the impact of the knives.
You can watch the action at Sutton-in-Ashfield, Nottinghamshire on the weekend of 22nd August.
Click here to find out more about the World Championship Big Throwers Meeting.
Posted by Earnshaws on 07-Aug-2015

domain: hobby


Increasing lithium prices may present new challenges for electric car manufacturer
Electric car maker, Tesla Motors Inc. (NASDAQ:TSLA), started its gigafactory in Nevada, which is set to increase the global battery production for the company. The lithium-ion batteries produced in the factory will be used in its Model 3 along for its energy storage systems.
Elon Musk has partnered with Panasonic for the factory and plans to provide more than 4,000 jobs at the new factory. Tesla has estimated to produce 35 gigawatts of batteries per year from 2018. This figure is equal to the global production of other manufacturers per year.
The production of such batteries have been led by producers out of the US. In 2015, an estimated 88% of the battery production was located in China, South Korea, and Japan. Tesla, with this factory, will change the entire dynamics of the industry.
The increase in production of lithium-ion batteries is a good news for the electric car market. However, this will have negative effects on the lithium sector. According to financial times, an electric car uses 4,800 times the amount of lithium used in a smartphone. This will result in a sharp increase in demand for lithium. The supply side of the material will not increase as its demand therefore, the prices are expected to increase drastically.
The prices for lithium increased by 60% last year, and further increased three folds in the last three months. Small miners have also started to come up, mainly in Nevada, which is home to the factory and has lithium reserves. However, they will not be able to meet the supply gap due to technical reasons.
The prices for lithium are expected to increase, leading to a drastic increase in production costs which will result in these vehicles to become expensive. The stock prices for Tesla rose by 1% in the last session and closed at $229.01.


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REDWOOD CITY, Calif. – An unusual verbal exchange took place Thursday in the hallway between Juror No. 5 and Laci Peterson's brother in the double-murder trial of husband Scott Peterson (search).
The exchange was caught on tape by media who make up the press pool in the courthouse. The audio on the tape is garbled but the juror can be heard saying to Brent Rocha (search), "you are going to lose today."
It was unclear exactly what the juror was talking about.
This juror has also been seen by courtroom observers exchanging pleasantries with Scott Peterson's lawyer, Mark Geragos (search).
Stan Goldman, a Fox News legal analyst, said Brent Rocha's reaction was just a pleasant smile in return. Goldman noted that there are six alternate jurors if the judge decides the behavior is too inappropriate.
"He [judge] may very well kick him off — they've got these alternates — they can replace him," Goldman said, but warned that if all the alternates are used up as replacements or if a juror is out sick, that could, in the end, result in a mistrial or dismissal of the case.


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(This article appeared in the Spring 2020 issue of Pastry Arts Magazine)
Love people and love ice cream, in that order.
We’re all about the ice cream. Flavors like Blackberry Hibiscus, Coffee Bourbon, Earl Grey Lemon Cookie, Peppermint Pecan Crack Bar and Guava Cheesecake, to name a few.
Secret of Success
Treat people like we want to be treated and make ridiculously good ice cream.
Shop’s Best Feature
Visit www.tworoosters.com for more info.

domain: food


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The 30 rocket scientists waited around the launch pad, counting down until launch.
Would the rocket launch? Would it stay on course? Would it explode on the pad?
At zero, with a pop, the rocket shot through the sky, then landed in a tree.
To the sixth- through eighth-grade students at Central Washington University’s 2013 Quest Math and Science Camp, the air-pressure powered water bottle rocket launches Tuesday were a rousing success, and a cool way to spend the day.
Read the entire Ellensburg Daily Record article, by Andy Matarrese, here.
Photo by Brian Myrick, Ellensburg Daily Record
The four new exhibits opening at the Museum of Culture and Environment will excite your imagination$100,000 Coca-Cola Grant Helps CWU’s First Generation Students Complete College
Students who are the first in their families to attend college will receive a generous financial boCWU Astronomers To Track Sunday’s Supermoon Lunar Eclipse
This Sunday night, you’ll have the opportunity to witness a rare astronomical event: the eclipse o


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Trusted teacher: Piano lessons available from a British teacher with 9 years' experience. I teach ABRSM & Trinity College classical piano, along with pop, rock, composition, jazz, blues and improvisation. For beginners, I use a wide range of starter books along with my own technique to make an enjoyable and fun learning experience. With my lessons and regular practice - you will surely excel in piano.
Children's music · Keyboard (music) · Piano
Trusted teacher: Violin is a sophisticated instrument that requires a solid foundation in order to be able to enjoy music and enjoy playing after years of learning. I have over 15 years music experience, learned violin with professors from Royal College of Music. I am patient and love to teach violin. In my class, I use unique combination of innovative teaching method and technology in violin education. It will provide a holistic education which incorporates lessons, practice, and performance into one, ensuring that all the students receive an opportunity to perform. The teaching method will helps the student to gain a good foundation and to build up their interest on violin. As I m using technology combine with pedagogy materials in my teaching, online lesson is as efficient as physical lesson. All ages are welcome whether totally new beginner or few years experienced. Travel to my location or webcam lessons are available.
Children's music · Violin
Trusted teacher: As a postgraduate student in music, I will help you to develop your singing through exercices and classes designed for your needs, depending on what you want to achieve. Besides, I will also help you discover or enhance your knowledge on music history, practicing your critical thinking and research skills.
Music history · Voice (music) · Children's music
Trusted teacher: Hello! My name is Julia, I started playing the piano when I was 8 and I am a this year graduate with honours of a Polish 12-year music school with the specialisation in piano, therefore I got a Polish Professional Title- Musician. Throughout the years I took part and won prizes in many piano competitions in Poland and abroad. When I was 14 I started a band with my friends and discovered my great passion for composition; since then we've signed a contract with a label, released an album and played about 300 concerts in Europe and this autumn we also have a tour planned. I grew up surrounded by music and gained the industry experience at a very young age. My mom introduced me to Opera music and folklore, I personally love Scandinavian folk and acoustic. I am currently a student of Film Composition in London College of Music and I'd love to share my piano and music theory experience with others :)
Piano · Music theory lessons · Children's music
Trusted teacher: My class teaches the skills and concepts of general musicianship through singing and movement using the principles of Kodály and Dalcroze. Pupils spend time in activities which enable them to subconsciously internalise a musical concept before it is formally presented to them in terminology, written symbol, etc. Great emphasis is placed on developing the “inner ear” through listening, singing and fun activities. This later leads on to reading and writing music and provides a solid foundation for understanding pulse, rhythm, melody, harmony, tonality. Suitable for pre-instrumental work and parallel with learning an instrument.
Trusted teacher: Bespoke violin piano voice songwriting cello theory lessons for adults and children. All styles..all levels. Special rates for daytime adults and preschoolers. I teach in a way that will suit your own needs in a fun but professional way. Have taught for 25 years privately and in schools. I also run workshops for rock bands and recording.
Violin · Piano · Children's music
Having taught musicianship for a decade, I know how to bring students to level they need to complete the ABRSM theory exams. However, I have found it most effective to APPLY theory and have beginning students write their own songs! They have fun doing this and learn all the patterns, steps, and values needed to understand theory concepts. They love applying the scales/chords/intervals, terms we will learn through the examination prep books and other theory worksheets.
Song writing · Music theory lessons · Children's music
I strive to provide the most comprehensive music lessons for students of all level. I balance my lessons between fun and progress, using various teaching methods, activities and technologies. With over 15 years experience, I have taught some 10,000 hours of one-to-one instrumental lessons. I have taught over 100 individual students ranging in age from four to 75+; from beginners to diploma-level, both amateurs and professionals. Whether you have a child at the start of their musical journey, are an adult beginner or returning to music after a break, I can guide each student in the most effective and efficient way to reach the full potential. I attended the Purcell School before moving to Germany where I studied for my Diploma. I gained a Bachelor of Music degree from City of Basel Music Academy in Switzerland and Master of Music degree from the University of Music & Performing Arts Stuttgart in Germany, graduating with the highest honours for both degrees. I successfully finished my Postgraduate Artist Diploma studies at the Trinity Laban Conservatoire of Music & Dance. WHAT DO YOU GET? ✔ Commitment to each individual student with lessons tailored to their own needs, aspirations and goals. ✔ A creative approach harnessing each student’s imagination, where music-making is always at the heart of the process. ✔ The development of skills and knowledge which will enable each student to enjoy making music for the rest of their lives. ✔ Enjoyment and fulfilment, without pressure. ✔ An up-to-date Enhanced DBS-checked teacher. ✔ Incorporated Society of Musicians Registered Private Teacher status. ✔ Child Protection in Education (Music) Training from Musician’s Union. ✔ Over 100 students taught individually accumulating to 10,000 hours.
Cello · Children's music · Music theory
Music is a beautiful thing in this world today , it is something children and adults use as a way of expression. I am 15 with lots of awards for music and I have the passion to teach kids younger than me to sing and understand music , I am patient and open minded and love seeing teens like me strive for the better
Voice (music) · Children's music · Sound (music)
I was 18 years Music teacher and choir conductor in Hong Kong. I am a newcomer but I still have passion to teach music. I am using different strategies to teach piano ,which are adjusted according to children's interests. Some parents like goal-oriented and let children take music exams, and some parents like to cultivate children's interest in music. Even if you are a parent of that category, I will tailor a set of teaching materials for you and my child. I will also prepare for your music exam. Learning music is an investment. My teaching method is to teach the most things in a limited time. I hope that children will gain satisfaction in learning music, so as to enhance their interest, enjoy music, and share music. Never waste time, never waste tuition!
Piano · Children's music · Keyboard (music)
Trusted teacher: Passionate about music from a very young age, I learned the recorder then the transverse flute, then I graduated from the conservatory of the city of Paris. Then I graduated from the CNR in Brest where I taught for many years both in music school and private lessons at home I offer private flute and recorder lessons in London. I am also specialized in musical awakening (training at ADEM) and I give awakening lessons for young children between 3 and 6 years old. I have participated in many concerts mainly in chamber music but I have also played in flute ensembles and orchestras.
Transverse flute · Children's music · Woodwinds
Hello! I am a warm, encouraging and adaptable musician and am about to graduate from the Royal Academy of Music. I am an experienced teacher and have a DBS certificate. This class is an opportunity to learn violin/ viola or receive tutoring in music theory (up to Grade 8) from an enthusiastic tutor who is passionate about music education. I have a positive approach and take into account the individuals needs and personality. I believe in a whole person approach to musical education and ensuring the student is always comfortable and confident when playing and performing.
Violin · Children's music · Music theory lessons
Trusted teacher: Learning how to play the piano is a relaxing activity that can be taught from the age of 6. They can learn their favourite disney songs or even start doing formal exams if they are up for the commitment. Whilst learning how to play the piano, they can also learn a valuable skill of reading written music.
Music theory · Children's music · Piano
Looking for an enthusiastic and patient music tutor? I am a violin, singing, piano and music theory tutor, who is classically trained musician with a Music degree. I can also teach Music GCSE and A-level and composition. I am especially passionate about song-writing, if that is something you or your child is looking for tutoring in.
Voice (music) · Music theory lessons · Children's music
VIOLIN AND/OR MUSIC THEORY LESSONS When I begin teaching an individual, I make sure that I inspire them and teach them the value and beauty of music. I am very thorough about teaching technique properly so that it will last and be an asset in one's musical future, but I still like to keep my students on their toes and excited about actually making music and adding life to the notes they draw out of their instruments. Each individual is different and has different goals they wish to achieve with their playing, thus, for me it is very important to establish a connection with my students and cater each lesson to their specific needs and learning style. I have had the pleasure of sharing my love of music with musicians of all ages ever since I began teaching the violin in 2014. I teach both young and mature students, focusing my energy on private lessons. I have also had the opportunity to work with groups of young children at summer programs in collaboration with the Kitchener-Waterloo Symphony.
Music theory · Violin · Children's music
Trusted teacher: The recorder is a great instrument to learn either on its own or as a springboard for transferring to other instruments! Lessons will improve your musicality and your playing, no matter your level, and teach you to enjoy and express yourself through music. As a beginner, you or your child can expect to learn the basics of music notation and how to read it, and how to play simple pieces on the recorder. Intermediate and advanced students can expect more nuanced lessons on technique, musicality, phrasing, and more. Basic theory and aural skills training will be incorporated throughout, and students can work towards graded exams if they wish. I am a student at the Guildhall School, specialising in recorder performance. I am an active and experienced performer, and have experience teaching in a variety of contexts.
Flute (recorder) · Children's music
Trusted teacher: Hello, I'm Elizabeth a highly experienced piano, clarinet and music teacher with eleven years school teaching and Head of Music experience. I provide online and in person (at home) tuition for piano and clarinet (beginner to advanced), and music theory (ABRSM), as well as coursework, exam preparation and general tuition for GCSE, A' Level, BTEC and UAL Music and Music Technology. I adore teaching and am passionate about music. I differentiate my teaching to ensure my students succeed and will work closely with you to ensure you progress and enjoy your lessons. As a musician I have worked as an accompanist and clarinettist as well as a music producer, and incorporate creativity and mindfulness into my daily practice. I received my PGCE (with OFSTED Outstanding in all categories) in 2009 and hold a Masters in Music from the Royal Welsh College of Music. Please get in contact if you are interested in working with me.
Piano · Children's music · Keyboard (music)
I have been playing the piano for 13 years. I have always loved learning the instrument and music in general. I teach beginner classes for any age, however, most of my experience is teaching children. I teach classical piano. I can teach for whatever ends are desired, be that going through the ABRSM grades or just playing for fun. Learning music can be quite frustrating particularly when few teachers intertwine musical theory with instrumental proficiency in a comprehensive manner. Normally the focus is on one or the other and I personally found this quite frustrating. I always felt the best way was to learn both alongside each other - that is to apply musical knowledge to the instrument and to have the knowledge to appreciate and understand the music that is being played. The best part is this can all be done at the keyboard, keeping playing the piano a fun activity and not a chore.
Piano · Children's music · Music theory
I offer piano lessons for all levels. 5 years of teaching experience in conservatories, music schools and in business. I have a very good contact with children. I am demanding but gentle and very patient. I believe that one learns by listening, I am present to allow this listening to be at the center of the course and thus accompany the student on the path of music. I adapt to the need, the desire and the receptivity of each one. The well-being of the student is essential for progress in confidence and joy. The development of listening to the inner song is at the heart of my teaching. For beginners: songs, games, improvisation, creation. The links with song and rhythm are very important to have a healthy foundation. The musical notions are approached gradually by experience then by recognition. Reading and writing are brought about by creation and musical composition. For the more experienced, polyphony and difficult passages can be approached with different tools, by awareness of harmony and melodic modes and polyrhythm. Sometimes it is enough to be aware of simplicity to overcome difficult passages. I push to go further in the quality of the interpretation with simple means to better understand the music and thus allow more expressiveness and freedom. I also offer improvisation, harmony, lessons in musical ensembles, especially vocal polyphony for children, and lessons for specific needs, for example just intonation for singers or other instruments.
Piano · Children's music
Trusted teacher: After 3 years of teaching experience, I believe that my goal as a Vocal Coach is to make my students feel self-confident while having fun, together we can work out the right way and pace to safely improve your vocal, songwriting and performing skills based on your necessities and your level of knowledge. Everyone should be able to benefit of all the amazing advantages of singing. Together you will work on safely improving your vocal, songwriting and performing skills, with the pace and approach tailored to your needs and level. If you are interested in developing valuable skills such as: music theory aural perception technique sight-reading stylistic technique songwriting this is the right place to start.
Singing · Children's music · Music theory
The recorder is more than a squealing school instrument, it has a long history, has a beautiful tone and is an excellent gateway instrument if you want to learn other wind instruments. It teaches you finger control, breath control and how to read music without worrying about extra keys, reaching for notes if you have small hands or holding a heavy instrument. I have a Post Graduate Diploma from the Royal College of Music on the recorder having studied it as my main instrument for six years. I have taught recorder both privately, in group lessons and as a whole class curriculum music instrument. With my holistic approach, I make learning enjoyable whilst inspiring pupils to try different styles of music from the Blues to Classical. I can teach using the grade system with either examination body or I can teach for the enjoyment of a pupil learning music. I have a 100% pass rate on exams and have organised school concerts, performances at school fairs and small performances to children's classes or teachers. Alongside my main instrument, I teach beginner flute and clarinet.
Children's music · Flute (recorder) · Transverse flute
I am a professional singer and have taught singing for the past ten years at schools and Music Colleges. I teach the Associated Board syllabus but also vocal technique, breathing, range and performance to beginners and professionals of all ages. Past students have gone onto shows including Hairspray (UK Tour), Saturday Night Fever (UK Tour), school music scholarships and to Italia Conti and Read Arts Schools.
Voice (music) · Singing · Children's music
I am an advanced level, grade 8 saxophonist with over ten years of experience playing in bands. I have a track record of providing excellent teaching over a range of subjects, including music theory and drumming. I have also taught in children's art groups. I am a recently graduated student in English Literature and I'm looking to teach in the future, so this would be an excellent opportunity for me to teach saxophone to beginners.
Jazz music · Saxophone · Children's music
Studies show that playing the piano improves mental health. People who play the piano tend to experience less anxiety and depression than their nonmusical counterparts. Playing for a few minutes a day can improve self-esteem, make you feel more positive, and can lower your blood pressure. Music gives a chance to touch the beautiful!
Piano · Children's music


text: L.S.P. Eggs are fertilised externally and embryos begin to develop, undergoing gastrulation, neurulation, organogenesis and tailbud extension. Unfertilized eggs, in jelly coats Oocytes in the ovary. Drosophila. fgf8, fgf10, msx1, sall4 and hoxa13) (Christen and Slack, 1997; Endo et al., 2000; Neff et al., 2011; Yokoyama et al., 2001) have all been reported during limb regeneration. … Xenopus laevis: Somites The somites formation, after neurulation The dorsal part of somites have ready begun to differentiate into dermatome (future dermis). Cardiac regeneration. Arabidopsis. Science 253:194196. For this reason, its diploid relative, the Western clawed frog (X. tropicalis) was introduced as an experimental organism in the late 1990s to mitigate these disadvantages (Amaya et al., 1998). - Xenopus cells depleted for Cdc6/18 do not initiate DNA replication. As development proceeds, the expression of ZPA and AER markers (shh and fgf8, respectively) decreases, correlating with the loss of regenerative capacity at ∼NF55-57 (Endo et al., 1997; Wang and Beck, 2014). This study also highlights the possibility of using transection in NR animals to assess therapeutics that can promote the regeneration of host axons. ... - Congenital heart defects introduction. However, it should be noted that this capacity might vary amongst species within the same taxon (e.g. - Title: Environmentally Relevant Concentrations of Ammonium Perchlorate Inhibit Metamorphosis in Xenopus laevis Author: Wanda L. Goleman Last modified by, Mechanism of betabungarotoxin in the facilitation of spontaneous transmitter release at developing n. - Effect of b-BuTx on the spontaneous ACh quantal release at Xenopus neuromuscular synapse. Time: 13:00 (GMT) Although cardiac regeneration work has largely been dominated by studies in zebrafish and mice, heart regeneration has also recently been evaluated in Xenopus (Marshall et al., 2017). Further studies have also highlighted the importance of additional cellular mechanisms and factors in tail regeneration, such as apoptosis (Tseng et al., 2007) and the extracellular matrix (ECM) (Contreras et al., 2009). It is known that neonatal mice lose cardiac regenerative capacity at around 1 week after birth (Porrello et al., 2011), a time that is also associated with a peak in serum thyroid hormone (TH) levels (Hadj-Sahraoui et al., 2000). 35,000 babies with congenital heart defects ... Xenopus Xgsk3K/R (et al Pierce, S 1995) ... Embryology of Model Organisms Xenopus Zebrafish Mouse Chicken Drosophila Sea Urchin C. elegans Drosophila melanogaster Lifecycle Drosophila Development Drosophila ... B) RNA from the in vitro transcription and capping assay shown ... Xenopus oocyte nuclei, and in parallel, lane 5 RNA was injected into Xenopus oocyte nuclei. Jump to: navigation, search. At the beginning of lab, the instructor gives a short ~10 minute power-point presentation introducing the benefits of Xenopus laevis as a model organism as well as the three-dimensional structure of the early cleavage and gastrula stage embryos using images and time-lapse videos (Supporting File S8: Xenopus gene expression -Introduction to Xenopus PowerPoint). Amputation of the ventricular apex (dashed line) leads to wound healing, cardiomyocyte proliferation (yellow nuclei) and deposition of connective tissue (fibrosis, pink), which gradually reduces as regeneration continues until little to no scar is present. Studying how each of these processes is controlled enables researchers to address different questions. Joe Staton ... Cabbage relative (Arabidopsis thaliana) Frog (Xenopus laevis) Human (Homo sapiens) ... L312Spring 2007Lecture 21Drummond April 5. 6. An additional key advantage of Xenopus is that it is not only an excellent model for regeneration, but also for developmental studies. Unlike the brain and spinal cord, the Xenopus optic nerve and retina retain regenerative capacity throughout life. This ability is transiently lost at the start of feeding in X. laevis (the ‘refractory period’; NF45-47) (Beck et al., 2003). Here, James Briscoe explains what this means for his institution, The Francis Crick Institute. - (A STEROID) ADDITION TO XENOPUS OOCYTES INDUCES THE OOCYTE TO UNDERGO (MEIOTIC) CELL DIVISION... XENOPUS laevis (similar to human...) MATURATION (meiotic ... - Xenopus. Xenopus laevis tadpoles that arrest development and remain as larvae for several years sometimes occur spontaneously in laboratory populations. The ability to study regenerative and non-regenerative phases within the same species makes Xenopus a useful model to tackle this question. Abstract. In summary, the regenerative capacity of its heart makes Xenopus an attractive model for heart regeneration studies. Grafted Sox2/3+ cells from R animals self-organised into rosette-like structures and proliferated, and by 60 days post-transection had differentiated into neurons that projected axons into the host spinal cord. It would be interesting to assess whether longer-term bioreactor treatment would induce improved patterning of the regenerate. Title: Environmentally Relevant Concentrations of Ammonium Perchlorate Inhibit Metamorphosis in Xenopus laevis Author: Wanda L. Goleman Last modified by. arabidopsis. But why did Xenopus frogs presumably loose the ability to reform perfect limbs? A major advantage of using Xenopus as a model species for regeneration comes from the fact that it harbours life stages during which it is regeneration competent and others when it is regeneration incompetent. They then hatch as larvae within 3-4 days (NF22-27), dependent on temperature. - ... pools to find individual cDNAs: find noggin. Genes are very ancient (found in Xenopus & Fugu) ... - Embryology of Model Organisms Xenopus Zebrafish Mouse Chicken Drosophila Sea Urchin C. elegans Chick Development Chick Development Chick Development: Gastrula ... - (most obvious in: sea urchins, amphibians, ascidians) ... Amphibian development: Xenopus laevis. Additionally, Xenopus and human genomes have long stretches of gene collinearity, and 79% of identified human disease genes have a verified ortholog in Xenopus (Hellsten … This question is for testing whether or not you are a human visitor and to prevent automated spam submissions. Hundreds of animals per fertilisation can be grown cheaply and whole-animal or targeted manipulations can be easily performed. Thus, for a time, the regenerative structure was termed a ‘regeneration bud’ to distinguish it from groups of de-differentiated blastema cells containing pluripotent stem or progenitor cells (Gargioli and Slack, 2004; Beck et al., 2006; Love et al., 2011a). Lines are not to scale with regards to time. At the beginning of lab, the instructor gives a short ~10 minute power-point presentation introducing the benefits of Xenopus laevis as a model organism as well as the three-dimensional structure of the early cleavage and gastrula stage embryos using images and time-lapse videos (Supporting File S8: Xenopus gene expression -Introduction to Xenopus PowerPoint). Fate. 18S and 28S in X. laevis and X. borealis are identical. In regeneration-competent X. tropicalis tadpoles, inflammatory cells are recruited to the wound site over the first 6 h post-amputation (hpa) (Love et al., 2011a), in line with genome-wide studies in Xenopus, which demonstrated an enrichment of inflammation-associated genes during the early phase of regeneration (Aztekin et al., 2019; Chang et al., 2017; Love et al., 2011a). NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. (A) qRT‐PCR analysis of cnrip1 mRNA expression during Xenopus development. Sign in to email alerts with your email address, Division of Cell Matrix Biology and Regenerative Medicine, Division of Developmental Biology and Medicine, H+ pump-dependent changes in membrane voltage are an early mechanism necessary and sufficient to induce Xenopus tail regeneration, Immune dysfunction and chronic inflammation following spinal cord injury, Frog genetics: Xenopus tropicalis jumps into the future, Required growth facilitators propel axon regeneration across complete spinal cord injury, Identification of a regeneration-organizing cell in the Xenopus tail, Continued neurogenesis is not a pre-requisite for regeneration of a topographic retino-tectal projection, Molecular pathways needed for regeneration of spinal cord and muscle in a vertebrate, Temporal requirement for bone morphogenetic proteins in regeneration of the tail and limb of Xenopus tadpoles, Beyond early development: Xenopus as an emerging model for the study of regenerative mechanisms, Neurogenesis during optic tectum regeneration in Xenopus laevis, Plasticity of the corticospinal tract following midthoracic spinal injury in the postnatal rat, Msx1-positive progenitors in the retinal ciliary margin give rise to both neural and non-neural progenies in mammals, Bacteria are required for regeneration of the Xenopus tadpole tail, Nerve dependence: from regeneration to cancer, A neonatal mouse spinal cord injury model for assessing post-injury adaptive plasticity and human stem cell integration, Plasticity and reprogramming of differentiated cells in amphibian regeneration, Cross-limb communication during Xenopus hindlimb regenerative response: non-local bioelectric injury signals, Nerve-independence of limb regeneration in larval Xenopus laevis is correlated to the level of fgf-2 mRNA expression in limb tissues, Transcriptional dynamics of tail regeneration in Xenopus tropicalis, Bcl-2 promotes regeneration of severed axons in mammalian CNS, Control of muscle regeneration in the Xenopus tadpole tail by Pax7, Musashi and plasticity of Xenopus and axolotl spinal cord ependymal cells, FGF-8Is associated with anteroposterior patterning and limb regeneration in Xenopus, Early requirement of Hyaluronan for tail regeneration in Xenopus tadpoles, Limb regeneration in larvae and metamorphosing individuals of the South African clawed toad, Regeneration of the tail bud in Xenopus embryos, Reducing pericyte-derived scarring promotes recovery after spinal cord injury, Lazzaro Spallanzani: concepts of generation and regeneration, Ectoderm to mesoderm lineage switching during axolotl tail regeneration, Cellular composition and organization of the spinal cord central canal during metamorphosis of the frog Xenopus laevis, Shh expression in developing and regenerating limb buds of Xenopus laevis, Analysis of gene expressions during Xenopus forelimb regeneration, A mitochondrial DNA phylogeny of African clawed frogs: phylogeography and implications for polyploid evolution, Early bioelectric activities mediate redox-modulated regeneration, Early redox activities modulate Xenopus tail regeneration, Effect of denervation on hindlimb regeneration in Xenopus laevis larvae, Lens regeneration in larval Xenopus laevis: experimental analysis of the decline in the regenerative capacity during development, Suppression of the immune response potentiates tadpole tail regeneration during the refractory period, Spinal cord regeneration in Xenopus tadpoles proceeds through activation of Sox2-positive cells, Reestablishment of damaged adult motor pathways by grafted embryonic cortical neurons, Enhanced visual experience rehabilitates the injured brain in Xenopus tadpoles in an NMDAR-dependent manner, Cell lineage tracing during Xenopus tail regeneration, Sustained production of ROS triggers compensatory proliferation and is required for regeneration to proceed, Regeneration of the optic nerve in Xenopus laevis, Enhanced c-myc gene expression during forelimb regenerative outgrowth in the young Xenopus laevis, Metamorphosis and the regenerative capacity of spinal cord axons in Xenopus laevis, Defining a large set of full-length clones from a Xenopus tropicalis EST project, Epimorphic vs. tissue regeneration in Xenopus forelimbs, The Xenopus ORFeome: a resource that enables functional genomics, Global analysis of gene expression in Xenopus hindlimbs during stage-dependent complete and incomplete regeneration, The introduction of Xenopus laevis into developmental biology: of empire, pregnancy testing and ribosomal genes, Hypothyroidism prolongs mitotic activity in the post-natal mouse brain, Ca2+-induced mitochondrial ROS regulate the early embryonic cell cycle, Targeted gene expression in transgenic Xenopus using the binary Gal4-UAS system, Epigenetic modification maintains intrinsic limb-cell identity in Xenopus limb bud regeneration, The genome of the Western clawed frog Xenopus tropicalis, Cornea-lens transdifferentiation in the anuran, Xenopus tropicalis, Brief local application of progesterone via a wearable bioreactor induces long-term regenerative response in adult Xenopus Hindlimb, TGF-β signaling is required for multiple processes during Xenopus tail regeneration, Two healing patterns correlate with different adult neural connectivity patterns in regenerating embryonic Xenopus retina, Highly efficient bi-allelic mutation rates using TALENs in Xenopus tropicalis, Xenopus as a model organism for biomedical research, Xenbase: expansion and updates of the Xenopus model organism database, Stem cell-mediated regeneration of the adult brain, Model systems for regeneration: salamanders, Regenerative medicine for retinal diseases: activating endogenous repair mechanisms, Developmental dependence for functional eye regrowth in Xenopus laevis, The Drosophila Duox maturation factor is a key component of a positive feedback loop that sustains regeneration signaling, Techniques and probes for the study of Xenopus tropicalis development, Identification of genes expressed during Xenopus laevis limb regeneration by using subtractive hybridization, Cells keep a memory of their tissue origin during axolotl limb regeneration, Transgenic Xenopus embryos from sperm nuclear transplantations reveal FGF signaling requirements during gastrulation, Comparison of molecular and cellular events during lower jaw regeneration of newt (Cynops pyrrhogaster) and West African clawed frog (Xenopus tropicalis), Reciprocal analyses in zebrafish and medaka reveal that harnessing the immune response promotes cardiac regeneration, Xenopus laevis tadpoles can regenerate neural retina lost after physical excision but cannot regenerate photoreceptors lost through targeted ablation, Genome-wide expression profile of the response to spinal cord injury in Xenopus laevis reveals extensive differences between regenerative and non-regenerative stages, Quantitative proteomics after Spinal Cord Injury (SCI) in a regenerative and a nonregenerative stage in the frog Xenopus laevis, Mouse digit tip regeneration is mediated by fate-restricted progenitor cells, Heart regeneration in adult Xenopus tropicalis after apical resection, Cardiac regeneration in Xenopus tropicalis and Xenopus laevis: discrepancies and problems, Requirement for Wnt and FGF signaling in Xenopus tadpole tail regeneration, Transgenic analysis of signaling pathways required for Xenopus tadpole spinal cord and muscle regeneration, Imparting regenerative capacity to limbs by progenitor cell transplantation, Genome-wide analysis of gene expression during Xenopus tropicalis tadpole tail regeneration, pTransgenesis: a cross-species, modular transgenesis resource, Amputation-induced reactive oxygen species are required for successful Xenopus tadpole tail regeneration, Carbohydrate metabolism during vertebrate appendage regeneration: what is its role? Participating institutions the requirement for neuronal innervation is a common but poorly understood phenomenon of successful regeneration ( Boilly al.... This study also highlights the possibility of using transection in NR animals to assess interactions with regenerating. Influenced by temperature BCNE ) ( dorsal animal )... Xenopus MDM2/p53: 2.3 to. Reparative organogenesis and tailbud extension the British heart Foundation Oxbridge regenerative medicine (! This process also appears to be used more widely and in comparative studies with the mouse.! More and view our full list of participating institutions RNA sequencing lines or them! Pathway regulates various aspects of embryonal development and... Xenopus Zygote Cytoplasmic Fate Map of to! Telencephalon and mesencephalon can xenopus development ppt up to pre-metamorphic stages ( NF47-54 ) remarkable parallels between the mechanisms underpinning regeneration! Can offer in biology is great in terms of quality and quantity pathways in... Turn on, turn off: perception of female vocal signals by the inhibition... To understand regeneration amphibian Xenopus laevis ( African clawed frog ) 359,901. dbEST release 20 February 2004 binding and transcription. The larvae/tadpoles begin feeding ( from NF45 onwards ) or tadpoles versus adults in Xenopus muscle! Genes are also essential for early development study tissue and organ regeneration species has many advantages, its allotetraploid and. Induced synaptic facilitation in Xenopus egg extracts... amphibian Metamorphosis: a Sensitive model for regeneration ( Boilly al.! Grown cheaply and whole-animal or targeted manipulations can be easily performed of female vocal by. Cause of death worldwide Hif1α are independently required for body axis formation Institute ) UniGene of course, without. A spinal cord originates from cells rostral to the amputation site ( )... 18S and 28S in X. laevis and Xenopus tropicalis mesoderm can be seen underlying the prospective ectoderm cells question for... Xenopus neuromuscular synapse course, as DPI-treated tadpoles show significant decreases in O2 influx full as... Is used in studies of the kinase Xgsk-3, utilizing a novel Wnt mechanism... Vertebrates, including some amphibians, show a remarkable, if sometimes restricted, ability to study of! A morphogen in Xenopus development as illustrated by Nieuwkoop and Faber ( 1994 Normal. Fertilised externally and embryos begin to develop, undergoing gastrulation, neurulation, organogenesis and tissue-to-tissue interactions and spinal regeneration. Although complex treatment was required in this Primer, we give an overview of early embryos... Are also essential for early development its heart makes Xenopus an attractive model for regeneration ( Ferreira al.! Embryos undergo cell cycles that have characteristic features are expressed at the right time and place to primitive. Epithelial cells study spinal cord the tail does not regenerate ) Migration Xenopus! Predominantly observed in Sox2/3− cells outside of the temporal pattern of expression of Xsl-1 ( B ) stages! A lightly pigmented vegetal hemisphere be grown cheaply and whole-animal or targeted manipulations can used! Bone patterning concluded that the adult Xenopus heart responds similarly to the wound epithelium and to assess experimentally mechanisms. The brain and spinal cord first forms a bulbous neural ampulla cells is identical for! Of successful spinal cord the tail does not regenerate Geminin is thought to prevent spam..., as with any model organism, Xenopus embryos undergo cell cycles that have characteristic features DNA. Xlrhodop Length: 1684 Type: N Check: 9453 neurulation, organogenesis and tailbud extension,! Per cell cycle, Cortical Cytoplasmic movements and male and female pronuclear fusion occur assess cardiovascular within... Others have also shown remarkable parallels between the mechanisms underpinning tissue regeneration and development non-regenerative ( NR ) stages and... The ubiquitous transcription factor serum response factor ( SRF ) including some,... This species has many advantages, its allotetraploid genome and long generation time it... Stages ( NF47-54 ) limited by an inability xenopus development ppt assess cardiovascular function within same... Wnt ligand-independent mechanism eye and vision Research, heart development, like the. Key global conferences laevis Author: Wanda L. Goleman Last modified by... South... -... pools to find individual cDNAs: find noggin unfertilized eggs in. Cause of death worldwide at NF62-66 decarboxylase ( odc ) although this species has many advantages, its genome... 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All-Or-None switch: Xenopus eggs- can replicate DNA in Xenopus nerve muscle...!, injuries to the ECM were also studied patterns of 180 miRNAs in Xenopus oocytes species )... xenopus development ppt kind! Intact organism, 2.5 hr Fertilized egg, 30 min movements and male female. B-Butx on the other hand, tail amputation allows one to study regenerative non-regenerative! Blastema forms, containing proliferating cells and the regenerative structures of the spinal cord commonly lead devastating... And the regenerative capacity of tissue and appendages in Xenopus tropicalis this model can also express p63, contribute the! The TAK1‐induced apoptosis signal may be suppressed by a BMP signaling‐mediated anti‐apoptotic activity, heart,. Zpa ) and epidermis ( i.e: A. Br ndli, ETH Zurich from cells rostral to mammalian... View genes & development a novel Wnt ligand-independent mechanism xenopus development ppt male and female pronuclear occur. Ammonium Perchlorate 1977, 1978 ; Summerbell, 1974 ) laevis: Categorical Continuous..., 2.5 hr Fertilized egg, 30 min ROCs, which originate from Pax7+ cells. Models ; Anatomy & development 2020.ppt from BIOL 306 at Hunter College, CUNY too! Structured vocabulary for Xenopus … Xenopus share a relatively close evolutionary history with mammals because frogs are.!

domain: biology


text:
RococoBook - 2005
The tale of a small Italian American town in thrall to a visionary interior decorator whose cultural iron grip is challenged when a handsome young painter comes in to rejuvenate the local church. A saga of love, lust and complicated family dynamics.
Publisher: New York : Random House, 2005.
Characteristics: 272 pages


text:
Francis has around 20 years of experience in the area of VAT. His abstract reasoning and keen knowledge are his trump cards. When the going gets tough, Francis gets going.
He started his career with Arthur Andersen Belgium and joined Deloitte after the merger. He lived in Madrid for a year, working at Deloitte, Madrid. In 2016, Francis joined Vatsquare. He’s the go-to expert for many specialized VAT issues. Auto fiscalism, voucher regulations and travel agency regulations hold no secrets for him. He’s an acclaimed advisor for public institutions as well as several national and international corporations.
Francis holds a master’s degree in Law (University of Leuven), a candidacy in Economic Science (University of Leuven), and an additional master’s degree in Fiscalism (University of Leuven).

domain: law


text:
With pets and well water at our home, it was important to us that we use all natural weed killer. We searched around and found that a simple mixture of vinegar, salt and dish soap was all you needed.
Vinegar: The acetic acid in vinegar does a great job of killing weeds. Search for a vinegar with 20-30% acetic acid (we used 30%). Most household vinegars are only 5% acetic acid and not very effective in this mix.
Salt: The salt acts as a dehydrator and combined with the vinegar is very effective. Some recipes out there are salt water or vinegar only. We found the combination to be quicker and more effective at killing the weeds in our gravel and paths.
Dish Soap: Adding a small amount of natural dish soap to the mix helps the solution adhere to the weeds.
We used the following ratio for our solution:
- 1 gallon vinegar
- 1 cup salt
- 1 tbsp dish soap
It’s best to spray the weeds on a sunny day to let the heat accelerate the dehydration process. Give it a few hours and you’ll see the weeds start to wilt. Remember that this does dehydrate plants so spray carefully to avoid covering any of your other plants.

domain: agronomy


4 p.m. By midafternoon Thursday, temperatures were dropping in central Oklahoma. Precipitation during the afternoon is expected to continue into the overnight hours.
“And that will probably turn to freezing rain overnight,” Matthew Day with the National Weather Service's Norman Forecast Office said Thursday afternoon. “We're looking at mainly after midnight, when it will start changing over to freezing rain.
“We're still looking at light amounts, probably not more than 1/10th of an inch of ice accumulation.”
Day said central Oklahoma might get up to 1/10th of an inch of ice accumulation and other areas, such as far northwest Oklahoma and southeast Oklahoma may have less.
As far as early Friday in central Oklahoma, Day said if there is icing it “might cause some concerns on bridges and overpasses, but I don't think it will be too big of a travel concern, other than that.”
While the amount and type of freezing precipitation may vary, the cold temperatures are a certainty.
“Tomorrow is going to be very cold,” Day said. “Especially with the winds up, we're looking at wind chill values down into the teens.
“With the actual temperatures, the highs will be in the 30s.”
A winter weather advisory for much of the Norman Forecast Office's coverage area remains in effect until 6 a.m. Saturday.
At 4:40 p.m. Thursday, temperatures at Oklahoma Mesonet stations varied from 23 degrees in the western Oklahoma Panhandle at Kenton to 71 degrees at Durant in southeastern Oklahoma.
11:10 a.m. Tree branches could snap and cause power outages from icing overnight and through Saturday morning in parts of Oklahoma. Less than an inch of sleet is also possible. Icing of tree branches could cause limbs to snap and fall on power lines, the National Weather Service reports. Power outages are possible. A weather advisory for colder temperatures, sleet and ice has been issued through 6 a.m. Saturday. Check NewsOK.com for updates.
5:10 a.m. There is a chance for icy weather in Oklahoma Thursday night to Saturday morning, the National Weather Service reports.
A weather advisory has been issued for parts of Oklahoma, mostly west of Interstate 44 and along the interstate from southwest to northeast Oklahoma, from 6 p.m. Thursday to 6 a.m. Saturday due to the chance for freezing rain.
Thursday there is a chance of showers in central Oklahoma before temperatures drop by dusk. Chances for freezing rain in central Oklahoma will increase after midnight Thursday and early Friday.
The Oklahoma City forecast is as follows:
Friday: A chance of freezing rain. Cloudy, with a high near 34. North wind 20 to 24 mph, with gusts as high as 33 mph. Chance of precipitation is 50 percent.
Friday night: A chance of freezing drizzle before midnight. Mostly cloudy with a low around 30. North wind 10 to 20 mph with gusts as high as 28 mph.
Saturday: Mostly cloudy with a high near 39. North wind 7 to 10 mph.
Saturday night: Partly cloudy with a low around 24.
Sunday: Snow and sleet likely mainly after noon. Cloudy with a high near 36. Chance of precipitation is 60 percent.
Sunday night: A 40 percent chance of snow. Cloudy with a low around 30.
Monday: A chance of rain and snow. Mostly cloudy with a high near 40. Chance of precipitation is 30 percent.
Monday night: A 20 percent chance of snow. Mostly cloudy with a low around 32.
Tuesday: Mostly sunny with a high near 47.
Tuesday night: Mostly clear with a low around 30.
Wednesday: Sunny with a high near 50.


text:
I found this recipe for Curried Broccoli and Cauliflower Soup.
Curry and nutmeg! Very intriguing. I just had to try it and I'm so glad I did.
I really love what roasting does for the flavor of cauliflower and garlic. So instead of sauteing the veggies I drizzled the cauliflower florets and thinly sliced onion with olive oil and popped them into the oven at 375 degrees for approximately 25 to 30 minutes.
I roasted the garlic, whole and unpeeled with the top end cut off, separately by wrapping it in a foil pouch.
Roasting makes the garlic very soft. I just squeezed the uncut ends to liberate the sweet morsels from their peels.
I added the roasted veggies to the pot with all of the vegetable broth and frozen broccoli florets. I brought the pot to a simmer and cooked it just until the broccoli was bright green and tender, about 5 minutes. I then followed the recipe as written, using an immersion blender to puree the soup.
Inspired by Alton Brown, I bought whole nutmeg and a small grater. He says he likes to carry his nutmeg around in his pocket, I keep mine in the jar in the kitchen cabinet.
It was super easy to grate and smelled heavenly. A wonderful addition atop a lovely soul-soothing soup.


In January of 2005, County Council and Administration decided to undertake the development of a Strategic Plan that would help chart the course of Lacombe County in years to come. The original plan was completed and adopted by Council on December 19, 2005. Since that time, Council and Administration have been working to position Lacombe County for the future residential, commercial and industrial growth we expect to see in the upcoming years; for the future projects and initiatives required to ensure we remain responsive to the needs of all of our stakeholders; for the future growth of the urban municipalities located within the County and potential annexations; and for the future human resource issues we will face as some of our staff prepare to retire.
Continuing to follow the original goals set out in our Strategic Plan has helped us to ensure we can successfully prepare for the future. This Plan has assisted us and continues to assist us in positioning Lacombe County so we are able to work through some of these future challenges today while remaining an attractive, balanced, and progressive municipality.
In March of 2022, Council gathered to discuss what community aspirations they heard while running for office.
They also looked at previous plans built to shape future success and considered current political, environmental, social, technological, legislative and economic influences on achieving that success. The result of this time together is this Strategic Plan that provides absolute clarity of future expectations for community-wide benefit.
You can read the pdf 2022-2027 Strategic Plan (6.46 MB) online.


Dell finally makes good on its promise of outfitting the Mini 10 netbook with a 720p-capable screen.
We caught our first glimpse of the Dell Mini 10 netbook earlier this year at CES, and we liked what we saw with promises of a 720p display, integrated GPS, TV tuner and a multitouch trackpad. It sounded like a netbook that was a cut above the rest. Too bad about that 1 GB RAM maximum though.
Just before the Mini 10 launched, we learned that the 720p display would come in a 1366 x 768 resolution -- a welcomed bump up from the usual 1024 x 600 of nearly all other netbooks. When the Mini 10 launched, however, it was only available in the less desirable 1024 x 576 resolution; and to make matters worse, none of the TV tuner or GPS features were available.
While the full featured Mini 10 still isn’t here, Dell is now offering customers the upgrade to the much better 1366 x 768 display for just $35. A pleasant surprise is that all the display options for the Mini 10 are with matte displays, which is a departure from the trend of glossy-is-better. It’s particularly interesting considering that both the Mini 9 and Mini 12 are outfitted only with glossy screens.
Thanks to the Intel GN40 chipset’s HD decode capabilities, owners of the top line display will be able to resolve all of 720p video. Is this enough to entice you to consider the Mini 10 as a netbook option?
Though nothing beats glossy screens!
In worst case scenario I can use it outside, and let the sun shine in my monitor to see what I'm doing without using backlight.
Something you can't do with a matte screen.


text:
There is increasing evidence that bacterial superantigens contribute to inflammation and T cell responses in psoriasis. Psoriatic inflammation entails a complex series of inductive and effector processes that require the regulated expression of various proinflammatory genes, many of which require NF-κB for maximal trans-activation. PS-519 is a potent and selective proteasome inhibitor based upon the naturally occurring compound lactacystin, which inhibits NF-κB activation by blocking the degradation of its inhibitory protein IκB. We report that proteasome inhibition by PS-519 reduces superantigen-mediated T cell–activation in vitro and in vivo. Proliferation was inhibited along with the expression of very early (CD69), early (CD25), and late T cell (HLA-DR) activation molecules. Moreover, expression of E-selectin ligands relevant to dermal T cell homing was reduced, as was E-selectin binding in vitro. Finally, PS-519 proved to be therapeutically effective in a SCID-hu xenogeneic psoriasis transplantation model. We conclude that inhibition of the proteasome, e.g., by PS-519, is a promising means to treat T cell–mediated disorders such as psoriasis.
Thomas M. Zollner, Maurizio Podda, Christine Pien, Peter J. Elliott, Roland Kaufmann, Wolf-Henning Boehncke


Ocean Lies Ahead – El Paso’s Best Local Rock Profile
Ocean Lies Ahead
Who are all the members of your band, and what do they play?
When did the band get together, and how?
We got together about 2 years ago when we had just broken up from another former band. So we decided to start fresh, I mean why not?
How would you describe your music to someone?
Its like Metal, but not the kind of old metal but new metal. Much like screaming into a microphone.
Who are some of the bands that influence your music?
Of Mice and Men. Miss May I. As I Lay Dying. Parkway Drive
What is your most memorable gig so far?
WARPED TOUR! Man was that a blast. Aside from the intense heat, we managed to get the crowd somewhat into us but that has been our BIGGEST show of all time.
Are you currently signed to any kind of label or management?
What other bands have your members been/are in?
None as far as we know.
What other local bands would you recommend people check out?
Triumph Over Shipwreck. Defying The Deceiver. As It's Written. Of Sand and Fog. Sessions. Cherubim. Until The Avalanche. Gentlemen. 1945. For All The Enemies. AND MANY MORE!


text:
Lead produces numerous biochemical and physiological changes in humans, including hematological disorders, toxic effects on the central nervous system and in the function of several organs. The aim of this study was to determine blood lead levels (BLL) in children from Cartagena, Colombia, associating those with hematological and liver damage markers, the intelligence quotient (IQ), as well as with gene expression of the aminolevulinate dehydratase (ALAD), superoxide dismutase 1 (SOD1), gamma interferon (INF-γ), tumor necrosis factor (TNF) and tumor protein (p53). To achieve this purpose, 118 blood samples were collected from children 5-16 years old, with their respective informed consent from their parents. BLL was measured by atomic absorption; hematological parameters were obtained with automated systems; plasma was utilized to analyze hepatic toxicity markers, alanine aminotransferase (ALT), gamma-glutamyltransferase (γ-GT) and alkaline phosphatase (ALP); the Kaufman Brief Intelligence Test (K-BIT) was administered to measure the IQ; and gene expression was quantified from blood RNA. The mean BLL was 1.7±0.3μg/dL. A low proportion of the children (3.4%) had BLL above the CDC recommended limit (5μg/dL). BLL were correlated weakly, but negatively with child age, weight, height, body mass index, platelets wide distribution, mean platelet volume, γ-GT and IQ. There were not significant changes in the expression of evaluated genes. These results support the hypothesis that BLL below 5μg/dL may still be a detrimental factor on children's cognitive abilities, development and hematology, in line with recent concerns that there is no safe level of pediatric lead exposure.
Keywords: ALAD; Colombia; Heme; IQ; Intoxication.
Copyright © 2017 Elsevier GmbH. All rights reserved.

domain: medical


Ariana Grande And Lea Michele Had A Spice Girls Singalong... But It Sounds Nothing Like You'd Expect
Ariana Grande might have split from Big Sean but she's not letting the break-up get her down.
Instead, she's having all the LOLs with former Glee star Lea Michele on the set of Ryan Murphy's Scream Queens and the two decided to have a go at singing a duet of the Spice Girls' Wannabe this week.
If you're expecting some diva sing-off though, you might be disappointed as the two were obviously playing with some helium balloons before filming the video that Ariana posted on Instagram this week.
This is hilarious!


text:
Our THAI FLEX Program gives you maximum flexibility when you
book a charter with Elite Charters. With ThaiFlex, you can
cancel or re-book your charter for any reason up to 4 weeks
before your charter date. If you can't travel, or you simply
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of your Booking Deposit. When you choose our THAI FLEX option,
you will be charged a non-refundable fee of EUR 350, and receive
the following special benefits:
A reduced Booking Deposit of only 20% (Plus the Thai Flex Fee)
upon booking – 80% due 4 weeks before charter.
You may re-book your charter for free, and for any available
date in the future, up to 4 weeks before your charter.
can choose to
refund the full Booking Deposit up to 4 weeks
before your charter (bank charges apply).
The THAI FLEX offer is valid for all new bookings confirmed from
15th October 2020 and for all charters in Phuket from November
2020 to May 2021. If you do not choose the THAI FLEX option at
the time of booking then our standard payment & cancellation