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Just north of Fairfield in Butler County, on the southern edge of Hamilton, you’ll find the historic district of Lindenwald. WVXU’s Tana Weingartner takes us to this re-emerging gem in our latest episode of the Community Storytelling InitiativeAround the corner.
It’s a beautiful spring day as Dick Scheid and I get into his car for a road trip. The retired science teacher and de facto historian of Lindenwald has lived here for decades, although he grew up in the western part of Hamilton.
“To get to Lindenwald for a date or with your buddies, you had to take a bus from the west side to the city center; you had to make a connection, which was a small ticket that allowed you to take another bus that would take you to Lindenwald,” he explains. “It felt like the end of the world here, that’s what I was talking about when I said they were allowed to develop on their own because they weren’t close to the city center.”
Lindenwald’s first pioneer settlers date back to the late 1700s, providing resources to nearby soldiers Fort Hamilton. In the 1850s newspapers referred to the “Village of Lindenwald”, although it was never incorporated.
The community was eventually annexed to Hamilton in 1908. The name comes from the German word meaning “linden forest”, although you would be hard pressed to find any today.
It was a railroad town, bordered on the east by the railroad tracks and the Ohio 4, and on the west by the Great Miami River. Stretching from the border with Fairfield north to Knightsbridge Drive, Lindenwald is the most populous of Hamilton’s 17 wards.
Lindenwald ‘an embarrassment of riches’
Have you heard of one of Lindenwald’s biggest companies? University of Miami Hamilton.
A working town, locals worked in the mills and factories – Shuler & Benninghofen, Hamilton Caster, Mosler Safe and many more were all within walking distance.
Largely of German and Appalachian descent, many families have been here for generations.
“Born and raised in Lindenwald, I’m a multi-generational Hamiltonian on both sides of the family,” jokes Brandon Saurber. “Lindenwald is the home of my wife and myself. We both grew up there.
Saurber is Director of Neighborhoods for the City of Hamilton.
“When we talk about third places – those places that are neither at work nor at home – Lindenwald is embarrassed to be rich, in this regard. They have more parks than any other area of the city, churches and the local bars. . It’s the parks and the churches and the local bars,” he laughs. “It’s funny, my dad’s dad always told him ‘Never leave your bar off’. angle spoil.’ “
Like his grandfather, Saurber believes these gathering places are important to the community.
Dick Scheid adds that people make the place.
“They’re fiery, and they’re unique. They’re pretty proud. I have a friend who says ‘God’s Country’ on his return address – Lindenwald. He’s Brandon Saurber’s dad, by the way.”
There may not be lime trees, but there is a lot of “porching”
Although not lime trees, many streets are lined with trees. People are always on the move. Accommodations range from stately homes along Pleasant Ave—it’s Hamilton Ave once you’re out of Butler County—to four American squares, Craftsman bungalows, and even several cottages—oh, and a castle.
“It’s a French chateau-like castle, actually,” Scheid clarifies.
What is the backstory?
“He was a typesetter for the Times-Star newspaper in Cincinnati and he just wanted to build a French chateau. And he did,” Scheid said.
One thing many homes have in common here are porches. On a nice evening, people don’t hide inside. They’re chatting with the neighbors – they call it swine. If you’re on your porch, it’s an open invitation.
“People will pass on the street and they’ll stop and visit for a while, which you don’t see too often. We have a lot of good times on the veranda – solving the world’s problems, one beer at a time,” Scheid laughs.
We’ll continue to explore Lindenwald in the weeks to come – how the community is changing, the businesses and people that make it special – and hopefully a treat or two.

domain: geography


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Ubisoft has made a series of blunders lately with Wii U gamers, garnering much rage and hatred toward the company. It seems they’re trying to turn that image around though, as games that were previously thought to not be headed to Wii U actually are. The first of these is Watch Dogs, which many gamers have been excited for and if a recent LinkedIn profile is to be believed, we can add Splinter Cell: Blacklist to the.. list.
Of course a LinkedIn profile is certainly not an official confirmation, but we had rumored confirmation that Watch Dogs would be headed to Wii U before Ubisoft officially announced the title. Given how reliant Sam Fisher is on gadgets, the Wii U GamePad could make an awesome addition to his toolbelt if this turns out to be true. What do you think? Will you be getting Blacklist if this rumor turns out to be true?
- Mario 30th anniversary Hot Wheels on the way
- Check out this crazy Splatoon domino set up
- New music coming to Splatoon on August 6
- Dragon Quest is skipping the Wii U entirely
TAGS: splinter cell blacklist, ubisoft

domain: game


I wrote! Reader NotesGo to section
On January 8, a sculpture was inaugurated in homage to Diego Maradona in Famaillá, Tucumán , and to the pride of those who live in the National Capital of Empanada said that the statue is the first in the world.
The play emulated the mythical goal of the best player of all time against England in the 86 World Cup and was placed on the Paseo de los Entrepreneurs, in front of Parque Tem& aacute; Historic tico of Famaillá. For his part, the mayor José Orellana had the initiative of the tribute arguing that he wanted a work that is unique and innovative and represents in a single image everything that Maradona was and meant for all Argentines.
If we consider that Famaillá is one of the localities that has more sculptures in the north, about 300 works that adorn the city, for the Tucumans perhaps it was not a surprise the initiative to immortalize Diego, but what did surprise the Maradonians from the rest of the country was that the work generates astonishment for being the only one in the world, as they argue in that place, and that is why hundreds of fans traveled to this city that dressed as a gala in an exciting act.
“The twin Orellana” as they call the mayor of Famaillá, described the event as very important, since this place has become one of the first municipalities to have a sculpture of Maradona with” La Mano de Dios ”, in turn commented that when Diego scored the goal to the English, he hit the slap and there he became The Hand of God, and that sculpture in life in image travels the world, but in sculpture was not done, Orellana told the local press.
This is the name of the sculpture in homage to Maradona who, increasingly, fans approach her to take a picture with the image of the athlete who made you cry with emotion when he gambeteed like no other in his golden times. Diego's life-size statue was inaugurated under a radiant sun and trees that decorate the Famaillá Historic Theme Park, where football stars fans were present in an act that thrilled everyone.
For his part, David Acevedo , director of tourism in the city, explained that before inaugurating the work they requested authorization from the daughters of Maradona, Dalma and Giannina since the initiative was always from respect and a way to give back to everything that Diego gave to the Argentines.
On the other hand, the official thanked the artists who made the work and stressed that he did it in just 20 days. He also stressed that it is Maradona's first post-mortem sculpture and the first to be made in the world remembering La Mano de Dios. In addition, he commented that the work is part of the 300 replicas that were made in the city, including the Cabildo, as well as statues of great personalities, which are part of Famaillá's tourist attractions.
It should be noted that during the ceremony a video was projected remembering unforgettable moments of Diego Maradona and the massive farewell they did to him at the funeral at Casa Rosada. Undoubtedly, it was the most emotional moment that Tucumans lived during the tribute.
In this way, The National Capital of Empanada received hundreds of fans to pay tribute to football star Diego Maradona, where his figure was immortalized thanks to the artists Tucumanos Bruno Salica and Angel Moreno .
Publication Date: 14/01/2021
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HSBC in talks to sell US credit card arm
Nikhil Kumar is The Independent's New York correspondent. He was formerly assistant editor on the foreign desk and has also done a variety of jobs on the city desk, where he wrote about markets, commodities and other business and economics topics.
Wednesday 10 August 2011
HSBC is in talks to sell its US credit card arm, with Capital One Financial seen as the leading buyer for the $30bn (£18.5bn)-plus business.
The bank confirmed the talks yesterday, but declined to name the possible bidders. However, speculation soon focused on Capital One, theVirginia-based company which earlier this year expanded its business by acquiring ING's online bank in the US in a $9bn deal.
The sale is part of HSBC's efforts to cut costs and refocus its sprawling international business under new chief executive Stuart Gulliver, who recently said the bank was making progress with the planned sale. "These discussions are ongoing and no decision has yet been made to proceed with any transaction," the bank said yesterday.
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Scottish independence TV debate: Pumped-up Alex Salmond bounces back in bruising second round against Alistair Darling
Do you realise just how foolish the UK looks?
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domain: economics


Last week, Kim Kardashian announced that Kanye West would be bringing back his popular music series "G.O.O.D. Fridays." Unfortunately, One Friday in the supposedly return of the series, and no music was to be found. Fortunately, the reality star takes to Twitter to update fans on Kanye's new music and also managing to drop a big collaboration in the process.
OVO Sound Radio Premieres New ASAP Rocky Songs">
There you have it, Kanye West has finished "No More Parties In LA," the song at the end of his recent released single "Real Friends."


Eligible applicants must be an elderly person and/or an individual with a disability. The primary goal for inclusion of any
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repaired most be income eligible and must agree to the terms of assistance. Application must be completed by owner of home.
If you need assistance completing the
application, call (815)936-3567
You must return all of the above listed documents for your application to be processed.


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- As our seas endure unprecedented heatwaves and are subjected to rampant oil and gas developments, they suffer like never before.
- Forty per cent of the latest round of North Sea oil and gas licences overlap with marine protected areas, and if approved would devastate habitats and wildlife vital to ocean health.
- Leadership is lacking with currently just 0.4% of England’s seas protected, but there is still hope if government and industry act urgently.
The blue of the ocean is calming, instantly boosting your mood when you gaze at the waves. But in recent heat maps of the north Atlantic, those calming blues have been turning an angry red as an extreme marine heat sent shock waves through ocean ecosystems.
Global heating is now happening at what United Nations secretary general Antonio Guterres has described as a “terrifying” rate, with scientists warning of mass mortality of marine wildlife as these underwater heatwaves ravage our ocean in the same way as wildfires take out vast areas of forest.
Nature’s alarms are met with continued exploitation
It is against this backdrop that we have witnessed our leaders’ abject failure to act.
In the hottest June in the country since records began, the UK’s environment minister resigned, citing the government’s “apathy” and “disinterest” in environmental issues; the ‘Retained EU Law Bill’ was pushed through without safeguards to prevent weakening nature protection; and Rosebank – the largest undeveloped oilfield in the North Sea – was deemed ‘likely’ to be approved for exploitation.
In July, Prime Minister Rishi Sunak confirmed the government will be issuing 100 new licences for North Sea oil and gas in the autumn. Forty percent of these licences are within marine protected areas, our investigation in collaboration with our partners Uplift has revealed. These regions are vital havens for our extraordinary sea life – calling an area ‘protected’ and then licensing these highly destructive developments is disingenuous ‘blue wash’.
Not only would new developments cause vast amounts of CO2 emissions, hastening a climate breakdown that will decimate ocean wildlife and cost countless lives around the world, but it will also lock us into a dead-end industry that will leave workers stranded and the UK economy lagging. Despite this, Sunak defends the new licenses arguing they are “entirely consistent” with net zero commitments.
Ocean health is critical in our fight against the climate crisis. It must be restored. Yet offshore oil and gas developments directly harm our already struggling marine ecosystems. Damage from drilling and pipelines will destroy extraordinary deep-sea sponge communities, ancient cold-water corals and more. A toxic cocktail of pollutants including neurotoxins, microplastic and, of course, oil itself will blight our internationally important marine wildlife, from seabirds to seals.
The ‘Retained EU Law Bill’ could have enshrined nature protection laws that would have provided some safeguards against this kind of destruction, yet the government stubbornly refused to write this into law, pushing back against sensible environmental safeguards put forward by the House of Lords.
Reasons for hope
Leadership is lacking, but we can still turn the tide and move towards thriving seas, a liveable climate and stable jobs. And we have seen inklings of progress.
In July, Defra announced three new highly protected marine areas in England’s waters – great news. Strong scientific evidence shows that creating havens free from the pressures of exploitation boosts the whole ecosystem and helps create more secure livelihoods for coastal communities.
The only downside is that these add up to just 0.4% of England’s seas. When the goal is to protect 30% of land and sea for nature by 2030, this is a drop in the ocean.
On climate, the Labour Party’s policy to end new oil and gas developments in UK waters, if elected, was applauded by both climate and marine scientists and activists alike.
In the run-up to the general election, all parties should be looking to the future, creating long-term strategies that can safeguard the UK’s astounding natural ecosystems and create a flourishing green economy.
Our seas are central to this. If we put in place the right policies now, they can provide us with the home-grown, low-cost, sustainable energy we need, and thriving marine ecosystems that support coastal livelihoods from wildlife watching to fishing.
Safeguarding our majestic ocean life, our coastal communities and our energy security should be reasons enough, but if the UK’s political parties need more: 80% of UK voters believe our ocean protection laws must be strengthened.
It’s time to deliver action.
This piece was initially published by SG Voice and is reposted here with permission.


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If, like me, you have been patiently waiting to be able to watch Difficult People on free-to-air TV or by streaming in Australia, then I have some fantastic news for us. The comedy hit starring Julie Klausner (who also created the show) and Billy Eichner is now on SBS VICELAND and SBS On Demand. Finally!
Produced by Amy Poehler, this dark, irreverent comedy focuses on ride-or-die besties, Julie and Billy. They are 30-something aspiring comedians living in New York City, and to make ends meet while pursuing their comedy dreams, Billy works as a waiter and Julie writes scathing recaps for television shows.
Completely self-absorbed, self-serving and wondering when they will get the break they so truly deserve, Julie and Billy are hardened New Yorkers, who don’t have time for your crap. They love taking swipes at Kevin Spacey, and you can’t help but love them. Their rapid-fire banter and chemistry are fantastic, you will wish you could somehow be a part of this very insular friendship (even though you know it could never happen, there’s no room for a third party with these two (just ask Julie's boyfriend).
Rounding out the season 1 regulars are Julie’s very easy-going, slightly quirky boyfriend Arthur (James Urbaniak) who works for PBS and Julie’s therapist mother Marilyn (Andrea Martin) who seems more interested in her hourly rate than her patients’ problems. And Billy’s co-workers, Nate (Derrick Baskin) and Denise (Gabourey Sidibe) who are married and own the restaurant where he works, and Matthew (Cole Escola), a fellow waiter and aspiring actor who is a nemesis of sorts for Billy. Plus, there is a who’s who of New York guest stars throughout the series like Debbie Harry (yes Debbie. Harry!), Kate McKinnon, Tina Fey, Lin-Manuel Miranda, Stockard Channing, Martin Short and Ken Burns, to name but a few.
Here’s a bit of a taster…
Julie Klausner on Julie Kessler:
“Julie Kessler kind of exists as my id, in the sense that she gets to say and do things that I couldn’t do, or have the good judgement to not go through with.”
Billy and Julie heart NYC!
- "We're New Yorkers we hate waiting!"
- "Yeah we're impatient and unhappy."
Difficult People airs on SBS VICELAND Mondays from 9:20PM. Seasons 1–3 are now available at SBS On Demand:
This week, SBS Viceland Channel Manager John Beohm takes us to task with the launch of UK comedy hit 'Taskmaster', Paul Hogan gets meta in 'The Very Excellent Mr Dundee', Andy Samberg and Cristin Milioti follow the groundhog in 'Palm Springs', Alexander Hamilton has a cameo in 'John Adams', and we press play on our SBS On Demand picks.

domain: entertainment


text:
Listen To 'Wake Up The Nation' Now
Paul's new album 'Wake Up The Nation' isn't officially released until Monday (April 19) but today we can give you a sneak preview of it.
The Sun are hosting an exclusive listening party where you can stream the album in its entirety.
Head to the Sun website
now to hear for yourself what all the critics have been raving about!


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Chickenfoot Set Album Release Date, Name New Single
Chickenfoot have named the song "Bigfoot" as the first single from their upcoming sophomore album. The single is expected to hit airwaves sometime later this month.
The second album from Chickenfoot, Chickenfoot III, also has finally been given a release date and will hit shelves on Sept. 27.
Bassist Michael Anthony describes Chickenfoot III as "a lot heavier than the first record."
According to vocalist Sammy Hagar, the album cover and first video will be in 3D.
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domain: artistic


Earlier this summer, the transit system that serves Columbus, Ohio, made a big announcement: It wouldn’t be seeking voter approval for a half-cent sales tax for transit.Read more
Charlotte’s seen rapid growth over the past several decades, but many say that boom has come at the cost of inclusivity and, perhaps, even a bit of the city’s soul. With the loss of many historic buildings and without much of an identifiable design vernacular — aside, perhaps, from the profusion of five-story apartment buildings — Charlotte’s even been accused of looking and feeling bland....Read more
Nearly 60 years after the major legislative victories of the Civil Rights Movement, two troubling patterns persist–one economic, one geographic. First, Black Americans possess significantly lower levels of wealth than White Americans. Second, residential neighborhoods across the country remain highly segregated by race.
These patterns and their connections to each other are largely...Read more
The message seems to be getting out — monarchs need milkweed. The charismatic orange and black butterflies seek nectar on a wide variety of flowers, but their caterpillars feed on no other plant. And that appears to be where the clarity ends. Even after planting and managing for several of the 16 milkweed species native to North Carolina, I was still perplexed by the monarch’s preferences and...Read more
When it comes to the creative scene, Charlotte isn’t often mentioned in the same breath with peer cities like Austin or Nashville. After all, the city’s unofficial tagline is “Banktown,” not something like “Music City” or “Keep Austin Weird.”
But Charlotte has a thriving creative...Read more
Quick–wherever you are, look at the people around you, or remember the last time you were in a group. Now imagine the group tripling in size. That’s the America Matthew Yglesias desires. In his book One Billion Americans, Yglesias argues that the U.S., with its 330 million people, is “empty,” with depressing future consequences for the nation and the world. His thesis: the U.S. should...Read more
When it comes to economic mobility – low-income children’s ability to rise from poverty – we’ve known for a while that where you live influences your chances of success. Now, a new study suggests it’s not just where you live, but who you know that can tip the odds.
A vast new project...Read more
Here’s another paradox from the COVID-19 pandemic: People drove less, but the streets got more deadly.
That’s especially true for pedestrians, a new report from Smart Growth America shows. “Dangerous by Design,” the group’s annual report highlighting pedestrian fatalities, shows that over 6,500 people were hit and killed while walking in 2020 – a 4.5% increase over 2019.
Charlotte’s losing three football fields a day worth of trees – or, at least, we were from 2012 to 2018. But after four more years of a torrid building boom, no one can say with any certainty whether that loss has accelerated, slowed down or remains unchanged.
The city of Charlotte hopes to soon begin work on an updated tree canopy analysis, to figure out how tree coverage is changing...Read more


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Shane Jiraiya Cummings
Shane Jiraiya Cummings is an award-winning Australian horror and fantasy author and editor. He lives in Sydney and is best known as a short story writer. He has had more than 100 short stories published in Australia, New Zealand, North America, Europe, and Asia. As of 2015, he has written 12 books and edited 10 genre fiction magazines and anthologies, including the bestselling Rage Against the Night.
Awards, Honors and GoHships:
Also involved: - Altair Australia - Australian Horror Writers Association - Brimstone Press
|This is a biography page. Please extend it by adding more information about the person, such as fanzines and apazines published, awards, clubs, conventions worked on, GoHships, impact on fandom, external links, anecdotes, etc.|


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This book is awfully biased toward her views but it still explains a lot. I'd love to chat with her about this century and see if any of her staunch objectivism would change.Perry Kuipers
If you are a fan of Ayn Rand and have read most of her books, then this book is a must-read. This helps to answer some questions that you still had after reading her nonfiction.Dave
This is a collection of questions and answers drawn from post-lecture Q & A sessions. Reads like a magazine interview (well, a 200 page interview) where a short question is followed by a short answer. Rand's ideas do not come across all that well in this "soundbite" form. (I should note that this a criticism of the Q & A format, not of Rand's philosophy.) There are a few interesting bits, like when she dresses down audience members who ask smart-assed questions or talks smack about public figures (especially Ronald Reagan and Jane Fonda), but this is not essential Rand by any stretch. In the introduction, the author (well, compiler, I suppose) says that this book was never viewed or edited by Rand (possibly because she had been dead for more than 20 years at the time it was released, but that's only a guess...) and therefore he does not know if she would have approved of it. I have my thoughts. This book is a passable way to kill a couple hours if you are already familiar with Rand, however I would strongly advise against using it as an introduction to her philosophy.David Robins
It is what it is: Ayn Rand's opinions on various matters from politics to literature, eloquently spoken and organized by categories.

domain: library


text:
CHAPTER XXV—HE IS GLAD THAT GOD DWELLS IN HIS MEMORY.
But where in my memory residest Thou, O Lord, where residest Thou there? what manner of lodging hast Thou framed for Thee? what manner of sanctuary hast Thou builded for Thee? Thou hast given this honour to my memory, to reside in it; but in what quarter of it Thou residest, that am I considering. For in thinking on Thee, I passed beyond such parts of it as the beasts also have, for I found Thee not there among the images of corporeal things: and I came to those parts to which I committed the affections of my mind, nor found Thee there. And I entered into the very seat of my mind (which it hath in my memory, inasmuch as the mind remembers itself also), neither wert Thou there: for as Thou art not a corporeal image, nor the affection of a living being (as when we rejoice, condole, desire, fear, remember, forget, or the like); so neither art Thou the mind itself; because Thou art the Lord God of the mind; and all these are changed, but Thou remainest unchangeable over all, and yet hast vouchsafed to dwell in my memory, since I learnt Thee. And why seek I now in what place thereof Thou dwellest, as if there were places therein? Sure I am, that in it Thou dwellest, since I have remembered Thee ever since I learnt Thee, and there I find Thee, when I call Thee to remembrance.
CHAPTER XXVI—GOD EVERYWHERE ANSWERS THOSE WHO TAKE COUNSEL OF HIM.
Where then did I find Thee, that I might learn Thee? For in my memory Thou wert not, before I learned Thee. Where then did I find Thee, that I might learn Thee, but in Thee above me? Place there is none; we go backward and forward, and there is no place. Everywhere, O Truth, dost Thou give audience to all who ask counsel of Thee, and at once answerest all, though on manifold matters they ask Thy counsel. Clearly dost Thou answer, though all do not clearly hear. All consult Thee on what they will, though they hear not always what they will. He is Thy best servant who looks not so much to hear that from Thee which himself willeth, as rather to will that, which from Thee he heareth.
CHAPTER XXVII—HE GRIEVES THAT HE WAS SO LONG WITHOUT GOD.
Too late loved I Thee, O Thou Beauty of ancient days, yet ever new! too late I loved Thee! And behold, Thou wert within, and I abroad, and there I searched for Thee; deformed I, plunging amid those fair forms which Thou hadst made. Thou wert with me, but I was not with Thee. Things held me far from Thee, which, unless they were in Thee, were not at all. Thou calledst, and shoutedst, and burstest my deafness. Thou flashedst, shonest, and scatteredst my blindness. Thou breathedst odours, and I drew in breath and panted for Thee. I tasted, and hunger and thirst. Thou touchedst me, and I burned for Thy peace.
Saint Augustine Bishop of Hippo, The Confessions of St. Augustine


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The Serrai di Sottoguda Canyon
The Gorge of “Serrai di Sottoguda”, unique, was created by a strong earthquake and, later on, by water erosion. Carved by the waters of Pettorina stream, stretches for about 2 km. from Sottoguda to Malga Ciapela, at the foot of the Marmolada mountain, the Queen of Dolomites. Today is a Nature Reserve and it is allowed to vsit it on foot only and, in summer, going by the little train. To visit Sottoguda, with its typical alleys and old barns.
“Serrai di Sottoguda”: suggestive gorge with peak walls hundreds of meters high wth a little space from each other. A wonder of the nature that fascinates and astonisches: the water of the stream gurgling among the rocks, crossing the road, flowing under 12 little bridges…the waterfalls that in spring, when ice thaws, impetuously fall from the rocks and in winter they are like ice-cathedrals. And then, some suggestive corners which tend to stop: the cave of the Holy Virgin, the crucifix, the small church of St. Antony. And yet…. the discrete whistle of the “little train of Serrai” which, at regular intervals, draws attention to accompany adults and children to the discovery of this wonderful place, in a sort of legendary parentheses.
First War Museum
The museum is located in the building of the cable car that is in the center of the “Memorial Zone” of the Italian and Austro-Hungarian combat positions. These positions that are carved into the rocky mass have recently been made accessible to visitors. The Museum can be visited during the period of operation of the cable car service, from the beginning of December until Easter and from June to September. The entry to the museum, in accordance with its commemorative purpose, is free.
The Serauta Memorial Zone commemorates and honors the men who fought on the Marmolada in the years 1915-1917, during the First World War.
The cave of Punta Serauta
From May 1916 to November 1917 the Italian soldiers had their positions here and lived in caves and walkways carved out the rocky masses of Punta Serauta. The Austrian soldiers themselves where positioned under the glacier and in the opposite rock formations of Forcella V – Sasso delle Undici. A part of these caves and walkways of Punta Serauta have recently been rendered accessible to visitors that can be visited in summer, following the itinerary suggested on the plan. Under the glacier and between the crevasses the Austrian army dug a complex system of caves and walkways, the famous glacier city. A model of this city is exposed in the museum.

domain: travel


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Heat the oil in a large frying pan over a medium heat. Add the bacon and fry until just crisp. Remove and set aside.
In the same pan, brown the chicken thighs on all sides (this will take about 5-10 mins) then transfer to a large casserole dish, sprinkle with the flour and set aside.
Add the shallot halves, the garlic and the mushrooms to the frying pan and brown for 5 minutes.
Spoon the mixture into the casserole dish then pour over the white wine. Add the thyme, season with salt and pepper, cover and cook on a low heat for 1 hour to 1 1/4 hours until the chicken is cooked and the sauce is thickened.
Just before serving, stir in the cream, warm through, without boiling then serve garnished with the chopped parsley leaves.

domain: food


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FiltersMain Ingredient Meal Type Prep Time
- Less than 15 minutes
- Less than 30 minutes
- Less than 45 minutes
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Dijon Tilapia with Sautéed Vegetable Medley
Treasures from the Tilapia fillets lightly breaded with Tone's Parsley Flakes, Bakers & Chefs™ Honey Mustard and Ritz crackers.
- Four 4 ounce Tilapia Fillets
- 1/2 tsp. Spice Islands® Mediterranean Salt Grinder
- 1 1/2 cup(s) Ritz® Crackers, crushed
- 1 egg
- 2 Tbsp. sugar
- 1/4 cup(s) all-purpose flour
- 1/2 tsp. Spice Islands® Black Peppercorn Grinder
- 2 Tbsp. Tone’s® Parsley Flakes
- 2 Tbsp. Dijon Mustard
- 2 Tbsp. Bertolli® Olive Oil
- 1 lb. vegetable Medley (Broccoli, Carrots and Cauliflower)
- 1 cup(s) Onion, yellow or white, diced
- 1/2 cup(s) Spice Islands® Black Peppercorn Grinder
- 2 1/2 tsp. Spice Islands® Roasted Garlic, Salt and Parsley Blend Grinder
- 1/4 cup(s) Hormel® Bacon Crumbles
- 1/2 cup(s) unsalted Butter (1 stick)
Directions for tilapia
- Place cracker crumbs into large bowl for dipping; set aside.
- Combine flour, salt and pepper in resealable plastic bag. Whisk egg, mustard and sugar in small shallow dish for dipping. Add parsley flakes to cracker crumbs. Line up bag and bowls in the following order: flour mixture, egg mixture and cracker crumbs.
- Add one tilapia fillet to flour mixture in the bag and shake to coat evenly.
- Dip the fillet into egg mixture, coating evenly, and immediately dip into cracker crumbs. Repeat steps 2 and 3 with remaining fillets.
- Heat olive oil in skillet over medium heat. Add fillets and cook approximately 3-4 minutes on each side.
- Serve immediately.
Directions for vegetable medley
- Heat unsalted butter in skillet over medium low heat.
- Add onions and sauté until tender, approximately 2 minutes.
- Add pepper, garlic salt parsley blend and vegetables. Stir to coat vegetables.
- Cover skillet and cook until vegetables are tender, approximately 6-8 minutes. Add bacon crumbles after 3 minutes and stir. Serve immediately.


text:
The idea of buying art online may seem like something that would never have been appealing to art lovers and collectors. One of the fundamental pleasures of art is the experience you feel when you look at a piece of art. But like most other products, buying art online has become more popular and appealing. In fact, buying art online is changing the way art is being bought, giving people far more opportunity and freedom in finding the art they like.
This being said, there are still some things to bear in mind which may help when buying art online.
The internet provides a means to view a variety of different artworks from a wide range of sources in very little time. There are only so many exhibitions and galleries you can visit in a day, however online, you can view hundreds of artworks in a relatively short time.
Searching on the internet can also be a good way of finding similar examples of something that you like but which is not available.
One of the drawbacks of buying art online is the lack of face to face interaction with fellow collectors, artists and gallery owners. Another, is not being able to get the “feel” of the artwork which you get when you view in person. So, when buying from an online gallery or website, it is always a good idea to use as many of the services they offer as possible. These include being able to contact site owner or the artist by email and using features they may have on their website such as zoom or View-to-Scale to view the piece. Another tip is to send the image to friends and ask their opinion.
It is always worth doing a bit of research about the online store. Have they been in business for a long time? Do they have a good reputation? Are the methods of purchase secure with recognized security certification? It is also worth checking the terms of their return policy and if artwork is provided with authentication. If buying on a site like eBay, make sure the seller has a very high reputation, which is shown on the auction page and their profile.
Buying art on the internet does have its drawbacks but it also provides a way to increase the range and variety of work that is available to you when you are considering a purchase. Overall buying online can be a way to increase your options rather than a replacement to other ways of collecting art.


text:
|Year : 2020 | Volume
| Issue : 4 | Page : 535-542
Validation of superiority of p40 over p63 in differentiating squamous cell carcinoma and adenocarcinoma lung
Vamshi Krishna Thamtam1, Shantveer G Uppin1, Monalisa Hui1, N Narendra Kumar2, K Bhaskar2, Stalin Chowdary Bala3, G Sadashivudu3, GK Paramjyothi2
1 Department of Pathology, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India
2 Department of Pulmonology, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India
3 Department of Medical oncology, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India
|Date of Submission||26-Feb-2019|
|Date of Decision||25-Jun-2020|
|Date of Acceptance||29-Jun-2020|
|Date of Web Publication||29-Aug-2020|
Dr. Shantveer G Uppin
Department of Pathology, Nizam's Institute of Medical Sciences, Punjagutta, Hyderabad - 500 082, Telangana
Source of Support: None, Conflict of Interest: None
Context: In this era of targeted therapy, it is important to distinguish the various subtypes of nonsmall cell lung carcinoma (NSCC). Diagnosis based on morphology alone is challenging in poorly differentiated carcinomas and core biopsies. Immunohistochemistry (IHC) helps in specifying the lineage for the subtype of NSCC. Till date, p63 is the most frequently used and sensitive marker for squamous cell carcinoma (SQCC). However, it is not specific and stains a subset of adenocarcinoma (ADC). Thus, a more reliable and specific marker is required for the diagnosis of SQCC. Objective: The objective of the study was to validate the diagnostic utility of p40 over p63 in differentiating pulmonary SQCC from ADC and NSCC-not otherwise specified (NOS). Materials and Methods: A total of 123 cases of NSCC were initially reviewed and subtyped blinded to the results of IHC. This was followed by a review of IHC slides which included p63, p40, thyroid transcription factor 1, Napsin-A, cytokeratin (CK) 5/6, and CK7. Results: There were 64 ADC, 19 SQCC, and 40 NSCC-NOS. IHC helped to confirm the morphological diagnosis in 62/64 ADCs and19/19 SQCCs. IHC classified the cases of NSCC-NOS into NSCC favoring ADC – 12 cases, NSCC favoring SQCC – 10 cases, and NSCC favoring AD-SQCC – 4 cases. Both p63 and p40 showed near equal sensitivity for SQCC (100% and 97%, respectively), whereas p63 showed far lower specificity when compared to p40 (51.3% vs. 100%). Conclusion: The present study confirms and validates that p40 is equally sensitive but highly specific than p63 in detecting SQCC. Hence, we recommend the routine use of p40 instead of p63 for the definite categorization of NSCC of the lung.
Keywords: Immunohistochemistry, lung, nonsmall cell carcinoma, p40, p63
|How to cite this article:|
Thamtam VK, Uppin SG, Hui M, Kumar N N, Bhaskar K, Bala SC, Sadashivudu G, Paramjyothi G K. Validation of superiority of p40 over p63 in differentiating squamous cell carcinoma and adenocarcinoma lung. Indian J Med Paediatr Oncol 2020;41:535-42
|How to cite this URL:|
Thamtam VK, Uppin SG, Hui M, Kumar N N, Bhaskar K, Bala SC, Sadashivudu G, Paramjyothi G K. Validation of superiority of p40 over p63 in differentiating squamous cell carcinoma and adenocarcinoma lung. Indian J Med Paediatr Oncol [serial online] 2020 [cited 2020 Oct 23];41:535-42. Available from: https://www.ijmpo.org/text.asp?2020/41/4/535/293838
| Introduction|| |
In the past, the only important distinction necessary was between small cell lung carcinoma (SCLC) and non-SCLC (NSCC). As targeted therapies have evolved for various subtypes of NSCC, there is an ever-increasing need for differentiating these subtypes. Distinguishing adenocarcinoma (ADC) and squamous cell carcinoma (SQCC) is important as the treatment protocols differ.
To a large extent, the hematoxylin and eosin (H and E)-stained sections are enough to study the morphology for a definite diagnosis. However, in poorly differentiated carcinomas, and more importantly for small/core biopsies, difficulty arises in subtyping NSCC accurately. It is mandatory for the small/core biopsies to be preserved for detecting the driver mutations making the tissue available for any required ancillary tests, especially immunohistochemistry (IHC) even less.
There are various IHC markers available to subtype NSCC. For ADC, the more important ones are the nuclear marker TTF-1 and the cytoplasmic marker, Napsin-A. SQCC has sensitive antibody markers like the nuclear marker, p63, and the cytoplasmic and membrane staining cytokeratin 5/6 (CK 5/6) antibody, among others. Novel antibodies always take antibody detection to new levels by being more specific and/or sensitive.
Till date for SQCC, anti-p63 antibody is the most frequently used nuclear marker. Although it has good sensitivity, it is not highly specific as it also stains other NSCCs. It is not useful, especially in cases of poorly differentiated NSCC-not otherwise specified (NOS) as it stains 15%–65% of ADC. Hence, there is a need for a reliable, easy to assess, and a more specific marker in diagnosing SQCC.
The anti-p40 antibody is highly specific for squamous/basal cells. Studies have shown this marker to have similar sensitivity as p63 and markedly high specificity for SQCC, as it stains a lesser number of ADC. The potential pitfall of diagnosing a p63-positive ADC as SQCC can be averted to a large extent if p40 is used. In this study, we have validated the utility of p40 over p63 in differentiating pulmonary SQCC from ADC and NSCC-NOS in a large cohort of biopsies and resected specimens (RSs).
| Materials and Methods|| |
A total number of 123 consecutive cases of NSCC diagnosed on core-needle biopsies (CNBs), endobronchial biopsies (EBBs), and RSs of the lung sent for histopathological evaluation to the department of pathology between December 2014 and May 2016 were analyzed prospectively. This study was approved by the Institutional Ethics Committee. The demographic data, clinical details, radiological features, and laboratory investigations were retrieved from the medical records. The SCLCs, carcinoids, lymphomas, mesenchymal neoplasms, metastatic carcinomas, and mesotheliomas were excluded from the study.
Initially, all the cases of NSCC were morphologically categorized based on the review of H and E slides blinded to the results of special stains and IHC results. Subsequently, special stains with Alcian–periodic acid–Schiff for mucin were reviewed wherever performed.
In all cases where IHC was done, the slides were reviewed to subtype the NSCC. In those cases where IHC was not done, the initial morphological diagnosis was considered as a final diagnosis. The primary panel of SQCC and ADC markers included p40, p63, CK5/6, TTF1, Napsin-A, and CK7. All IHCs were performed on fully automated immunostainer (Xmatrx Elite; BioGenex) by Poly horse raddish peroxide (Poly HRP) technique. Of the primary antibodies used, Napsin-A was supplied by Biocare, p40 by Pathinsitu, and the rest by BioGenex. All were monoclonal antibodies except p40.
All cases of NSCC were categorized as per the proposed International Association for the Study of Lung Cancer American Thoracic Society European Respiratory Society classification for small biopsies., For all the markers, the intensity of staining was taken into consideration and was compared to positive controls. For the SQCC markers, p40 and p63, nuclear staining was accepted, and cytoplasmic staining was ignored. For p40 and p63 antibody, the intensity of staining was scored semi-quantitatively using a 3-tier system: weakly positive (Grade 1), moderate positivity (Grade 2), and strongly positive (Grade 3). The staining proportion pattern was scored on a 4-tier system: <5%; 6%–25%; 26%–50%; and >50%. Cases showing positivity of 5% or less were considered negative. However, H-score was not determined.
The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of both the ADC and SQCC markers were analyzed.
| Results|| |
Of the 123 patients, nearly three-fourth, 92/123 (74.8%) were male with a male-to-female ratio of 3:1. The age of the patients ranged from 18 years to 84 years, with a mean age of 57.8 years among males and 51.8 among females. Nearly 94.3% of the samples received were small biopsies, with only a small fraction of 7 (5.6%) cases being surgical resection specimen. Of the biopsies, majority were computed tomography-guided CNB [95/123 (77.2%)], followed by EBB [20/123 (16.2%)]. There was only one biopsy which was done under ultrasound guidance.
ADC was the most common histological subtype accounting for more than 60% (74/123) of NSCC cases. Of these, more than 80% (62/74) were diagnosed on H and E slides alone with the remaining 12 cases (16.2%) requiring IHC for subcategorization. Of the total 64 ADC cases diagnosed on H and E morphology, majority (46 [71.9%]), were acinar type, followed by lepidic type (10 [15.6%]), mucinous (4 [6.3%]), papillary (3 [4.7%]), and fetal subtype 1 (1.5%). Most of the acinar-type ADCs showed pure acinar morphology (38 cases) with remaining showing predominantly acinar morphology in combination with other morphologies like solid pattern (4 cases) and 1 case each of papillary, cribriform, and focal micropapillary pattern. There was one case which had an additional combination of lepidic as well as micropapillary pattern. Two of the four cases which showed predominant acinar morphology in combination with solid areas were categorized as adenosquamous carcinoma (AD-SQCC) after IHC. These two cases showed expression of SQCC markers in solid areas and ADC markers in acinar areas. Of the 10 cases of lepidic subtype, 8 cases had a pure lepidic pattern and 2 cases had additional micropapillary and acinar patterns.
Although NSCC-NOS formed the second major subtype, 40/123 (32.5%) on H and E morphology, 24 (60%) of these were further subtyped on IHC. These included 12 cases as NSCC favoring ADC, 10 cases favoring SQCC, and the remaining 2 cases as favoring AD-SQCC. Still, 16/123 (13%) cases could not be further subcategorized and were retained as NSCC-NOS. Of these 16 cases, IHC slides were not available in 6 cases and the rest 10 remained uncategorized even after an appropriate panel of IHC.
SQCCs accounted for 23.6% (29/123) of the cases of NSCC in the present study. Of these, 19 (65.5%) were diagnosed on H and E morphology alone, while the remaining (10 [34.5%]) required IHC to favor a diagnosis of SQCC. The distribution of the cases based on histological subtype before and after IHC is provided in [Table 1].
|Table 1: Distribution of the cases of nonsmall cell lung carcinoma based on histological subtype before and after immunohistochemistry|
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IHC was done in 110/123 (89.4%) cases, of which both p40 and p63 was performed in 107 (86.9%) cases. The most common IHC markers performed included lung ADC markers, TTF-1 and Napsin A, and SQCC markers, p63 and p40. The other ADC marker, CK7 and the SQCC marker, CK5/6, were performed in a smaller number of cases. The results of ADC and SQCC markers done in the NSCC cases are provided in [Table 2] and [Table 3], respectively. The morphological and immunohistochemical features of SQCC and ADC are depicted in [Figure 1], [Figure 2], [Figure 3].
|Figure 1: (a and b) Squamous cell carcinoma (H and E; a, ×40; b, ×100). (c) p63 and (d) p40 showing diffuse strong nuclear staining in the tumor cells (c and d, ×100). (e) TTF-1, negative in tumor cells. Few cells showing nuclear staining at the periphery of tumor nests are normal alveolar epithelial cells which serve as internal positive control (e, ×100). (f) Napsin A, negative in tumor cells. Few cells showing granular cytoplasmic staining at the periphery of tumor nests are normal alveolar epithelial cells which serve as internal positive control (f, ×100)|
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|Figure 2: (a and b) Adenocarcinoma showing predominantly lepidic pattern with focal acinar pattern (H and E; a, ×40; b, ×100). Both (c) p63 and (d) p40 being negative in the tumor cells. Please note nonspecific cytoplasmic staining with p40 (c and d, ×100). (e) TTF-1 showing diffuse strong nuclear staining in tumor cells (e, ×40). (f) Napsin A showing diffuse strong granular cytoplasmic staining in tumor cells (f, ×40)|
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|Figure 3: (a and b) Adenocarcinoma showing lepidic, acinar, and focal micropapillary patterns (H and E; a, ×40; B, ×100). (c and d) p63 showing nuclear positivity in the tumor cells. Staining of nuclei of the basal cells of bronchiolar epithelium serves as internal positive control (c, ×40; d, ×100). (e and f) p40 being negative in tumor cells. Staining of nuclei of the basal cells of bronchiolar epithelium serves as internal positive control (e, ×40; f, ×100)|
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Squamous cell carcinoma markers
As stated earlier, SQCC markers, p63 and p40, which were the main subjects of the present study, were performed in 107/123 (86.9%) NSCC cases, which included both morphologically differentiated and undifferentiated NSCC cases. Both p63 and p40 showed near equal sensitivity for SQCC (100% and 97%, respectively), whereas p63 showed far lower specificity when compared to p40 (51.3% vs. 100%). Only one case in which p40 was negative but p63 was positive was a case of NSCC-NOS on initial morphology which was later categorized as NSCC favoring SQCC after IHC. This case showed additional positivity for CK5/6 and was negative for both TTF-1 and Napsin-A. None of the ADC cases were positive for p40, whereas p63 was positive in half of the cases of ADC including majority of the morphologically well-differentiated ones. Majority of ADC showed Grade 1 to Grade 2 positivity in 5%–50% of cells. However, there were also cases showing Grade 3 staining, as well as staining in more than 50% cells. There were five cases where p63 showed weak staining in 5%–25% which were not categorized as NSCC favoring SQCC and retained as NSCC-NOS. These five cases were negative for p40 and two of these where CK5/6 was also done showed negative staining. In one of these cases, ADC markers were negative, while in one case, they were not performed.
Of the total 4 cases finally categorized as NSCC favoring AD-SQCC, two were morphologically ADC (predominantly acinar with focal solid areas) and the remaining two were morphologically undifferentiated (NSCC-NOS). In all these cases, there were distinct areas of staining for ADC markers (TTF-1 and Napsin-A) and SQCC markers p40 and CK5/6 (done in 1 case), but the marker p63 showed overlapping positivity both in squamous as well as in glandular areas.
This study also documented high sensitivities of the markers TTF-1 and Napsin-A for ADC. The sensitivity of TTF-1 and Napsin-A was 92.42% and 89.23%, respectively. Although TTF-1 showed slightly higher sensitivity compared to Napsin-A, both were 100% specific. One case of invasive mucinous ADC showed negativity for both TTF-1 and Napsin-A, while for another double-negative case, no primary was found in any other part of the body even after extensive investigations; hence, it was categorized as primary lung ADC. This case was a morphologically well-differentiated ADC of acinar type and was positive for CK7.
There were four cases of ADC which showed discordant staining for Napsin-A and TTF-1. Two of cases were Napsin-A postive and TTF-1 negative, with other two showing the reverse pattern of staining. None of the ADC markers were positive in SQCC. As stated earlier, both TTF-1 and Napsin-A distinctly highlighted the ADC areas, while the remaining negative in SQCC areas of all four cases of NSCC favor AD-SQCC. [Figure 4] and [Figure 5] show cases categorized as NSCC favoring ADC and SQCCC after IHC, respectively. [Figure 6] depicts adenosquamous carcinoma which was initially categorized as ADC with solid and acinar patterns on morphology.
|Figure 4: (a and b) Nonsmall cell lung carcinoma-not otherwise specified on morphology showing nests and cords of tumor cells infiltrating the fibrous stroma (H and E; a, ×40; b, ×100). (c) p63 showing positivity within the tumor cells (×100). (d) p40 being negative in tumor cells. (e) TTF-1 showing diffuse strong nuclear staining in tumor cells (e × 100). (f) Napsin-A showing moderate granular cytoplasmic staining in tumor cells. This case was later categorized as nonsmall cell lung carcinoma favour adenocarcinoma after immunohistochemistry|
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|Figure 5: (a and b) Nonsmall cell lung carcinoma-not otherwise specified on morphology showing nests and cords of tumor cells infiltrating the fibrous stroma (H and E; a, ×40; b, ×100). (c) p63 and (d) p40 showing positivity within the tumor cells (c, ×100; d, ×100). (d) TTF-1 and (e) Napsin-A being negative in tumor cells (e, ×100; f, ×100). This case was later categorized as nonsmall cell lung carcinoma favoring SQCCC after immunohistochemistry|
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|Figure 6: (a and b) Adenosquamous carcinoma which was initially categorized as adenocarcinoma with solid and acinar pattern on morphology (H and E; a, ×40; b, ×100). (c) p63 Showing diffuse nuclear staining in solid areas. Few nuclei in the glandular areas also show positive staining. (c, ×100). (d) p40 also showed diffuse nuclear staining in solid areas but negative in glandular areas (d, ×100). (e) TTF-1 showing positive nuclear staining in glandular areas but negative in (f) solid areas (e, ×100; f, ×100). (g) Napsin-A showing moderate granular cytoplasmic staining in tumor cells but is negative in (h) solid areas (g, ×100; h, ×100)|
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The sensitivity, specificity, PPV, and NPV of ADC and SQCC markers are provided in [Table 4] and [Table 5], respectively.
|Table 4: The sensitivity, specificity, positive predictive value, and negative predictive value of adenocarcinom markers|
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|Table 5: The sensitivity, specificity, positive predictive value, and negative predictive value of squamous cell carcinoma markers|
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| Discussion|| |
Approximately 85%–90% of all lung carcinomas are NSCC. ADC is the largest group among NSCC, followed by SQCC, NSCC-NOS, large cell carcinoma, AD-SQCC, and sarcomatoid carcinoma. Prior to 2004, the precise subtyping of NSCC was not necessary. Treatment options for NSCC included primarily surgery, radiation, and platinum-based chemotherapy. Major therapeutic advances have had a profound impact on pathological diagnosis and molecular testing, and it is now imperative to subtype NSCC. Epidermal growth factor receptor mutations or anaplastic lymphoma kinase translocation in ADC have different specific targeted treatments, and so the small biopsy material needs to be conserved for molecular testing. In this context, ancillary testing, especially IHC, becomes very important in the correct diagnosis of small biopsies/cytology material and poorly differentiated lung cancers (NSCC-NOS).
According to Travis et al., there is no well-established grading system for ADC, but grading according to the predominant histologic architecture is a simple and reproducible method and seems to be of prognostic importance. In the present study, we classified ADC based on this approach. Similar to Travis et al., we also found an acinar pattern to be the most common histological pattern (48.4% vs. 71.9%). However, unlike the present study, they found solid pattern as the second most important histologic pattern (37.7%). There was no solid pattern in this study. The solid areas in our study were seen in combination with predominant acinar pattern in four cases. This combination of pattern probably is the reason which might have reflected a higher incidence of an acinar pattern as the predominant histologic pattern in this study.
IHC was performed in 110 of the total 123 cases in the present study, while 107 cases had both p63 and p40 performed. In the present study, it was possible to diagnose more than 80% of ADC and more than 65% of SQCC on morphology alone without the need for special stains or IHC. Among the poorly differentiated/undifferentiated cases (40/123), IHC was able to favor a definite diagnosis in 24 cases.
The antibody, anti-p63, recognizes two isoforms of the p63 gene product, the TAp63 isoform, which contains the N-terminal transactivation domain and acts as a tumor suppressor, and a truncated isoform known as p40 (ΔNp63), which lacks the N-terminal domain and acts as an oncogene. The new anti-p40 antibody recognizes only the ΔNp63 isoform and not the TAp63 isoform.,
Many studies have established the lack of specificity of p63 for SQCC.,, Quest for a more specific antibody has brought about the novel antibody, p40, which is both sensitive and specific for lung SQCC. In the present study, the antibody p40 was nearly as sensitive as p63 for detecting SQCC but was far more specific than p63 for SQCC. According to several studies, apart from staining squamous cells, p63 also stains 15%–65% of ADCs. This lack of specificity is more important in the context of limited tissue availability for categorization as well as for further molecular testing to administer the targeted therapies. In our study, p63 stained 50% of ADC, while p40 did not stain even a single case of ADC. The comparison of IHC results for p40 and p63 in NSCC in different studies including the present series is provided in [Table 6].,,,,,
|Table 6: The comparison of immunohistochemistry results for p40 and p63 of the present study with others|
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The reported sensitivity for p40 has ranged 75%–100% among various studies. The present study showed a very high sensitivity of 96.97% which is comparable to the results of Bishop et al., Righi et al., and Dvorak et al.,, All the studies, including the present one, have shown p40 to be highly specific for SQCC with reported specificity ranging from 90% to 100%. Our results are consistent with that reported by Collins et al. who also documented 100% specificity with p40. In the present study, we used a polyclonal antibody of p40, which has shown nonspecific cytoplasmic staining and also staining of macrophages. However, being a nuclear marker, the cytoplasmic staining was not a hindrance to the definite categorization of lung NSCC. The nuclear staining was distinctive enough to make a definite diagnosis. Bishop et al. and Tacha et al. also used polyclonal antibody for p40 similar to the present study and noticed similar nonspecific cytoplasmic staining., Tacha et al. compared monoclonal with polyclonal antibody for p40 and found no statistically significant difference in terms of sensitivity, specificity, and predictive values between the two antibodies, except for nonspecific cytoplasmic staining observed with a polyclonal antibody. Dvorak et al. compared the results of two monoclonal antibodies for p40 (BC28 and VP Echelon 40) and noticed a slightly higher sensitivity for BC28 compared to the other clone.
Most of the published studies have reported p63 to be a highly sensitive antibody for SQCC with reported sensitivity ranging from 85% to 100%. The present study demonstrated p63 to be 100% sensitive for SQCC, similar to that reported by Bishop et al. However, the reported specificity of p63 has varied from 64% to 97%. Our study showed the lowest specificity of 51.3% when compared other studies. In regard to our study, the results are closer to the lower specificity of 64% reported by Bishop et al. We are unable to explain such variable specificity reported in different studies as most of the other studies used similar cutoffs as applied in the present study. In the present study, tumors positive for p63 but negative for p40 and CK5/6 were diagnosed as SQCC only if they were diffusely and strongly positive for p63 and negative for TTF-1 and Napsin-A.
The present study also showed TTF-1 and Napsin-A to be highly sensitive and specific markers for lung ADC. Both showed comparable sensitivities of 92.42% and 89.23%, respectively, with 100% specificity. However, Tacha et al. noted slightly lower sensitivity and specificity for TTF-1 (69% and 94.7%) as compared to the present study. However, the sensitivity and specificity of Napsin-A were similar in both the studies.
In the present study, it was possible to accurately subtype 26/40 cases of NSCC-NOS on IHC. Twelve cases favored ADC, ten cases favored SQCC, and 4 cases favored AD-SQCC after IHC. Based on our results, we recommend a panel of three markers including TTF-1, Napsin-A and p40 to subclassify most of the poorly differentiated NSCC.
| Conclusion|| |
The present study compared two lung SQCC markers – the routinely used monoclonal antibody, p63, and the novel polyclonal antibody, p40, and confirmed as well as validated that p40 is equally sensitive but highly specific than p63 in detecting SQCC. Despite being a very sensitive marker for SQCC, p63 lacks specificity and stains 50% ADCs as reported in other studies. The results of the present study confirm and expand upon the previous studies that p40 is a more specific marker for lung SQCC than the already established marker in routine use, p63 antibody. Hence, we recommend the routine use of p40 instead of p63 for the definite categorization of NSCC of the lung. Our results also confirm that TTF-1and Napsin-A are equally sensitive and specific markers for ADC of the lung.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
| References|| |
Bishop JA, Teruya-Feldstein J, Westra WH, Pelosi G, Travis WD, Rekhtman N. p40 (ΔNp63) is superior to p63 for the diagnosis of pulmonary squamous cell carcinoma. Mod Pathol 2012;25:405-15.
Thunnissen E, Kerr KM, Herth F. The challenge of NSCC diagnosis and predictive analysis on small samples. Practical approach of a working group. LungCancer 2012;76:1-188.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, et al
. International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma. J Thorac Oncol 2011;6:244-85.
Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA Cancer J Clin 2012;62:10-29.
Pikor LA, Ramnarine VR, Lam S, Lam WL. Genetic alterations defining NSCC subtypes and their therapeutic implications. Lung Cancer 2013;82:179-89.
MitsudomiT, Morita S, Yatabe Y. Gefitinib versus cisplatin plus docetaxel in patients with nonsmall cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): An open label, randomised phase 3 trial. Lancet Oncol 2010;11:121-28.
Travis WD, Rekhtman N, Riley GJ, Geisinger KR, Asamura H, Brambilla E, et al
. Pathologic diagnosis of advanced lung cancer based on small biopsies and cytology: A paradigm shift. J Thorac Oncol 2010;5:411-4.
AO MH, Zhang H, Sakowski L, Sharma R, Illei PB, Gabrielson E, et al
. The utility of a novel triple marker (combination of TTF1, napsin A, and p40) in the subclassification of non-small cell lung cancer Hum Pathol 2014;45:926-34.
Weinstein IB, Joe AK. Mechanisms of disease: Oncogene addiction-a rationale for molecular targeting in cancer therapy. Nat Clin Pract Oncol 2006;3:448-57.
Nonaka D. A study of ΔNp63 expression in lung non-small cell carcinomas. Am J Surg Pathol 2012;36:895-9.
Righi L, Graziano P, Fornari A, Rossi G, Barbareschi M, Cavazza A, et al
. Immunohistochemical subtyping of nonsmall cell lung cancer not otherwise specified in fine-needle aspiration cytology a retrospective study of 103 cases with surgical correlation. Cancer 2011;117:3416-23.
Tacha D, Bremer R, Haas T, Qi W. An immunohistochemical analysis of a newly developed, mouse monoclonal p40 (BC28) antibody in lung, bladder, skin, breast, prostate, and head and neck cancers. Arch Pathol Lab Med 2014;138:1358-64.
Collins BT, Wang JF, Bernadt CT. Utilization of p40 (ΔNp63) with p63 and cytokeratin5/6 immunohistochemistry in non-small cell lung carcinoma fine-needle aspiration biopsy. Acta Cytologica 2013;57:619-24.
Dvorak K, Yambert J, Palting J, Reinhardt K, Roessler C, Moh A, et al
. Improved lung cancer classification using new optimized immunohistochemical assay with anti-p40 (BC28) mouse monoclonal antibody. Int J Clin Exp Pathol 2016;9:2693-701.
[Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5], [Figure 6]
[Table 1], [Table 2], [Table 3], [Table 4], [Table 5], [Table 6]

domain: medical


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(UNDATED) - According to the Mega Millions lottery website, the jackpot has reached $500 million on Wednesday.
The Mega Millions jackpot continues to grow by millions of dollars, making it the largest total in U.S. history.
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Unifi switch solid white light
Use the command info to view the current firmware from the USG command line. Power: Solid green LED that indicates the router is powered up. Outlet & Switch Covers. I have everything plugged in properly and the device has a solid white light but the web interface setup page doesnt detect the device and Im not sure why. Main Port. Since the original release Ubiquiti has put out the Unifi Cloud Key Gen2 which largely solves this problem by including a backup battery that allows it to safely shut down when the power As of the v1. a Switch which connects to your Access Point. (3,734) $5. I'm really confused by this because a solid white light should theoretically indicate that all is well. UniFi : Device Physical Reset Print. Lutron DVCL-253P-WH Diva 250-watt Single Pole/3-Way CFL/LED Dimmer This is Lutrons high watt dimmer switch. It will flash when there is wireless data transfer. For a device like a Unifi switch or AP it is not so direct/obvious. Secondary Switch: UniFi Switch US-8-150W Will host upto 4 x G3 Cameras and Upto 3 x UniFi AP-AC Lite Access Points. if htere is not a solid network LED i don’t think this is the issue here. Blinking Amber (Slow) Your Wi-Fi Gateway is receiving an update. Second-Generation UniFi Switching We’ve redesigned our UniFi Switches from the ground up. One of the LAN ports I connected to the Unifi switch Learn how to fix a blinking white LED status light on a Ubiquiti cloud key. Starting in late November when running firmware and controller software all the Cloud Keys became unresponsive after the update the one in my office went into the adopt setting (solid white light) but could not be adopted. xx:8443. Wait for the status LED to turn solid white on all 3 devices to start the configuration via the UniFi Controller. This is a classic case of UNIFI router hardware bottleneck. Once the username and password has been entered, you can input the reset command line syswrapper. Only 2 Left. $75 for AP-AC-LR: This is a few years old, always been solid. 11-12-2020 05:13 PM. Flashing White / Off every 1/2s The device is initializing and booting up I've upgrade a UniFI Cloud Key Firmware to the current version of UCK. The system will spit out information about the install and then reboot itself. Message 15 of 23. Email to friends Share on Facebook - opens in a new window or tab Share on Twitter - opens in a new window or tab Share on Pinterest - opens in a new window or tab TP-Link 5 Port Gigabit PoE Switch, 4 PoE Ports @56W, Desktop, Plug-and-Play, Sturdy Metal with Shielded Ports, Fanless, Limited Lifetime Protection, Traffic Optimization, Unmanaged (TL-SG1005P) 4. Acrylic Flat Mirrored Vent Grill Covers. 3af switch for PoE power and data. possiably a system only restore but i doubt if it will • Plain white walls often look best with metallic switch plates. x 2 ft. HDMI Port. Near Silent Cooling Our new airflow design reduces the need for fan usage. No blue Q1: Why my PD fails to work when connected to the PoE switch and the LED light on the switch isn’t on? A: Troubleshooting steps: Make sure the PD is a standard device based on IEEE802. Mesh: Flash green LED indicates that the router is pairing with another router. Push in wire terminals accept #14 AWG solid wire. Electricity is one of the most important details in the home. Glass Switch Plates in Mirror, Clear, Frosted and Acrylic. Under Wi-Fi, find Ubiquiti UniFi. Next steps: Best Solution. try a new network cable. The UniFi AC Pro AP is a gigabit, 802. xx. tar. Sale Ends in: 98 days 0 hours 28 mins 17 sec. Punched Star Switch Covers in Pewter, Soft Black, & Bronze. White Porcelain Victorian Style Switch & Outlet Plug Cover Plate Cover (ZP-6) Price: $14. Toggle Switches. White LED ENERGY STAR Flat Ceiling Fixture with Selectable Color Temperature. Ready for configuration. The LED did turned solid red at "Test Internet Connection" step. This HDMI port connects to a TV or monitor with an HDMI cable. Their initializing images, showed a pulsing white\amber light while turning on, mine were green (not standard). Decorative Wall Plate Collections Shop from our thousands of decorative switch plate designs. Click “Install” and then “Configure”. Note that for modern APs like the Unifi 6 LR, it has a Bluetooth transmitter, so if you have a cell phone near you, it will actually ask about setup. Re: E3200 Extender Blinking Yellow Light and No White Light. Product Name: UniFi 16-Port PoE Switch. This is an easy way to get a complete network in one shot. 3 af/ t Mec h an ic al Har d war e LE D s The light patterns are unintuitive but when you power up, it flashes every 0. 7 out of 5 stars. Once the factory reset is complete, the light will 2. Our solution was to allow it to fail and disconnect, then to do that reboot thing it does to the point where it holds the white light solid for a few seconds, and then shove the reset button until the blue light comes on, then release and let it reboot. As for routers, Ive a UniFI UAP AC Pro (test date 12/24/16) Until last night it was rocksteady and we found it was in a slow blue/white flash this morning - decided to reset it and now its on the plain solid white colour This can be found on the settings page on the controller as shown below. The UL-listed switch is compatible with Decora wall plates and is recommended for replacing most standard single-pole switches. As a homeowner, you will likely need to replace a light switch many times and paying an electrician is not optimal when you can do it in just a few minutes. I followed all great tutorials in this forum, in Im trying to set up my Ubiquiti AC-Lite access point. $ 799. Ceramic switch plates can take on a number of different textures and colors, which is what makes this collection so diverse. cheers Update - Yoga 510-14 Decorative Switchplates from Switchplate Gallery. 00 FREE shipping. The UniFi Switch 8 150W offers the flexibility of (8) Gigabit RJ45 ports with auto-sensing PoE+ or 24V Passive PoE to power your UniFi access points and other PoE devices. ) is perfect for any low ceiling area and the no glare, edge-lit LEDs are integrated so GL-B1300. How many ports do you need? You might be better off just getting a US-24-250W (rather than two separate switches). Hand made in USA from durable steel. Last week, after using WD My Cloud for seven months without any problems, I tried to access the device (blue led, at this particular time) and nothing … Then I just did the reboot, pulling it from the outlet and putting it back - same with network cable. power it up. Its plug-and-play Mesh technology provides simple network-sharing configuration, and its 600-foot coverage is suitable for indoor and outdoor applications. I got a solid white light on it and nothing else. Here are some simple steps to follow when you want to physically factory reset a UniFi access point: I'll try both together with a standalone switch. 99. While the LED patterns below are shown for Access Points, the rest of the UniFi device LED patterns have the same meaning. The table below does not apply to the following EdgeSwitch XP (ES-XP) models: Hold reset button When you visit any website, it may store or retrieve information on your browser, mostly in the form of cookies. Example URL: https://136. Get the right light for any situation or Get the right light for any situation or task with the Commercial Electric 2 ft. The reset button is usually located right next to the ethernet port of your UniFi hardware, and requires a needle-sized tool to press and hold until it lights up again. 24 from 5. step 3: wait for solid white on both. . Please wait until the light turns back to solid white. Achieving full Internet speed is possible when you are using the The mixture of red, green, and blue photons emerging from the device produces white light. Manufacturer Part Number: USW-16-POE. 30 AUD. White Porcelain Victorian Style Triple Light Switch Plate Cover (ZP-10) Price: $19. 818cc5f. After turning the lights on, we want to set the lights to a solid color and call the preset to our dim red preset. I wanted this to replace an older non-managed 8 port switch. CORSAIR RIPPER: AMD 3970X - 2080TI - 64GB Ram - 2. I've plugged the controller into the PS4 and tried starting the system like that to get it to re-sync. But there is more to it: Description. This British General 1-Gang 2-Way 10AX Architrave Narrow Light Switch White has dimensions of roughly 87. Brand Name: Ubiquiti. Alternating Blue/White. 22 of 25 found this answer helpful. If you are looking for Unifi Shows Disconnected, simply check out our info below : Looking to move some UniFi equipment I'm not using anymore. Have noticed the power button is shorted to ground even not when pushed. I had the device running and configured within 15 minutes of opening the box. SouthTexasHomeDecor. Buyer to pay estimated shipping. You will need to hold in the button until the LED light goes off. This Cisco SG112-24 switch provides Twenty-Four (24) 10/100/1000 Gigabit Ethernet ports and all of the features, expandability, and investment protection you expect from Cisco, with no installation software and nothing to configure. The UniFi Switch models are available with 8 PoE Gigabit Ethernet ports of auto-sensing IEEE 802. With that approach, the light’s color temperature could be tuned by varying the structure of the DBR stack. 168. You may not be able to login process hangs on the Unifi controller or be otherwis Your Unifi cloud key's LED light should now be back to blue from white, responsive, and working with your old configuration again. 52. Hi have acquired a laptop to repair and it has shown some signs of life with a solid white light and reading the battery voltage and the voltage coming into the board it seems fine but will not power on. I placed the AP in a central location in my house where Wi-Fi is commonly used and this device work phenomenally throughout my entire home and yard. Unifi AP AC PRO UAP-AC-PRO-US 802. The light in the access point will blink white and then move to a steady white light Download & install the unifi controller software on to a laptop (it'll need java) Start the controller software, it will list the access point, click to adopt it It'll lead you through a setup (pretty much just configuring a wifi SSID. Solid green: The gateway is getting power and ready for use: No action: Blinking green: The gateway is booting up: Wait for boot up to finish: Solid red: The gateway found a problem while self-testing: Reboot gateway; if this doesn't solve the problem, contact your Authorized fusion Internet dealer: Blinking red The gateway is upgrading unique design UniFi Switch 48 Non-PoE: Computers & Accessories professional integrated online shopping mall Managed Gigabit Non-PoE Switch 48x Gigabit Ethernet ports Unifi Shows Disconnected. If your Wifi point is already set up and the light is off, check your light brightness settings in the app. Whitelist Envoy’s static IPs to allow a connection to your UniFi controller. 1. 5 x 33 x 21. Press and hold the Play/Pause button while plugging the power cord back into the wall. Step 2 Launch your Unifi controller, and the usw-flex-mini should show up in “Pending Adoption” status as show below: Step 3 Fla s hing White : B ootup in P r og r e s s Fla s hing B lue : Fir mw a r e U p g r a ding S te a dy White : Fa ctor y D e fa ults , Aw a iting Adop tion S te a dy B lue : D e v ice is Adop te d Ethe r ne t G ren : 1, Am b0/ M p s P oE Ambe r : I E 802. 20 does not respond, and I do not see any new DHCP leases on my router. Ive a UniFI UAP AC Pro (test date 12/24/16) Until last night it was rocksteady and we found it was in a slow blue/white flash this morning - decided to reset it and now its on the plain solid white colour At the command line type: sudo syswrapper. LED Below you will find the correct way to reset an Unifi Switch and also a couple of tips for when the adoption won’t succeed. step 4: unplug bring extended to your room location spot. The Kasa Smart Wi-Fi Light Switch connects to your home's secure Wi-Fi network. Below you will find the correct way to reset an Unifi Switch and also a couple of tips for when the adoption won’t succeed. adapter DEFINITELY has power and battery is only a month old. The white light will blink for a few seconds while the switch boots up. Product Line: UniFi. Supply reliable Wi-Fi connection for your enterprise with this Ubiquiti Networks UniFi Mesh access point. Here is the setup: Internet from ISP router goes to my ASUS wireless router (WAN port) , also DHCP server. Posted August 20, 2017. 200430. This will factory reset the device so that it can be re-provisioned. This information might be about you, your preferences or your device and is mostly used to make the site work as you expect it to. Check that the power cable is properly connected to your Wifi point and a working wall outlet. Firstly, you know you’ve just plugged in a UniFi managed switch into you network, so let’s click on the Switches icon; What you’ll notice when you click into that page is that the UniFi managed switch is now showing, but it is showing at the Pending Adoption stage; So, I rearranged my network setup back to Router mode (Unifi Huawei Modem > Deco). 11ac PRO Wireless Access Point - Enterprise Wi-Fi System The UniFi AC Pro AP supports simultaneous dual-band, 3x3 MIMO technology in the 5 and 2. ) you can easily create a DHCP reservation on the controller so a MAC address always gets the same IP. Assigning a DHCP reservation to a Unifi device (such as a switch or router) is unobvious. Connect your usw-flex-mini to a LAN port on your local network, and power it up. Hold the button until the light flashes amber and white. x at any rate). I selected "Skip this step", returned to the Advanced setting in Deco app, and enabled IPTV/VLAN option. 0950 and when it came back up after restarting it has a solid white light indicating its reset to factory defaults for some reason? Switch is stuck on solid white light (waiting provisioning). 2mm. You can load up it with 250W of LEDs, for example, if every bulb on your circuit is a 10 watt LED bulb, then you can have up to 25 on the circuit since the max LED wattage load is 250 watts. $192$293. The UniFi Network Controller and mobile app allow admins to configure and monitor virtually all of the switch features in a graphical user interface from anywhere. 6. This 10/100/1000 RJ45 port connects to an 802. The Romani Blue table lamp features a gorgeous white ceramic body adorned with strokes of blue artfully painted throughout. com. (3,382 Views) Step 1: plug the yellow Ethernet cables together. The hot wire in a 120-volt residential AC circuit usually is coated with black insulation, while the return, or neutral, wire is white. ) is perfect for any low ceiling area and the no glare, edge-lit LEDs are integrated so Hi, thank you for your product enquiry. This way you can install it, reset it and see what happens more easily than walking upstairs to check the light all time 😉 Step 2 – Manage your Unifi AC There are multiple options to configure your Access Point, you can use a Controller (a small piece of software), cloud controller (requires Cloud Key) and a mobile app. 3af-powered access point suitable for indoor or outdoor use. After working with support and doing a much of SSH crap which did not work. Away Mode. Product Model: USW-16-POE. Solid white The Leviton Decora 15 Amp Illuminated Switch is a designer-style device with a locator light that illuminates while in the off position to help you find the switch in dark rooms. Enter your UniFi Controller URL (on-prem IP and port, or Cloud URL). Enter your Controller username and How to Wire a Light Switch Learning how to wire a light switch is one of the basic skills that every homeowner should do. This weather-resistant Ubiquiti Networks UniFi Mesh access point Perhaps the most common way of resetting UniFi access points is by physically pressing (with a light touch) the reset button on the back of the unit. Once the reset has finished, the device will show a solid white/orange light (LED light colour will depend on the model). Led Indicator. With a small paperclip, you will need to press to the button for 5 seconds to factory reset the switch. Resetting an Unifi Switch. MFB (Mining/Folding/Boinc): AMD 3600 - 1080Ti & 1070Ti - 16GB Ram - 240GB NVMeSSD. Thats about it. c. About Unifi Shows Disconnected. 5 years. Each of these switch plates is hand made and features colors that are eye-catching, yet not overwhelming, so they don't necessarily need to be the centerpiece of your dÃ©cor. Solid White. Step 1: Reset the AP with the Reset Button. UniFi Security Gateway which Is a wired router and FireWall, and it is older and slower than UDM, UniFi Cloud Key – this is a controller allows you to manage all of your network equipment, Also a 4-ports switch – The closest one is the 5 port switch or 8-port switch, No light: Wifi point has no power or the light was turned off in the app. For clients (computers, phones, etc. Please wait while it starts up until the light turns solid white. Go to your motherboard manual and it will tell you what the solid orange light means. same time. Q1: Why my PD fails to work when connected to the PoE switch and the LED light on the switch isn’t on? A: Troubleshooting steps: Make sure the PD is a standard device based on IEEE802. The Sengled Smart Light Switch enables you to control your Sengled Smart LEDs with a click of the button. What this means is that your device is not yet adopted by your network. 12 Custom Designs Switch Plates in 38 custom finishes. 3af/at or configurable 24V passive PoE to simplify your infrastructure. Mount it to your wall - no wiring required - or keep the remote close by for easy control. the white light comes on solid and then it usually connects after a few seconds. I purchased a UniFi AC Lite in hope that it would boost my home Wi-Fi signal throughout my entire home. Adopt UniFi Managed Switch to Your Network. Blinking Yellow (Fast) Phone Registration has failed; one of your VoIP lines is having a problem. Great condition. A single-pole, single-throw switch — such as a light Go to Integrations > All integrations. I had it hooked up to the charger all night, woke up the next morning, saw that the battery The AP boots up and goes solid white, so I think I'm ready to go, but the controller (installed on my server) does not see it. 50. Shop eaton 15-amp 4-way rocker light switch, white in the light switches section of Lowes. Once you’ve got the device plugged in, you’ll notice that the physical device has a solid white light on, then turns to a flashing white light for a minute or so, then turns back to a solid white light. step 2: power up the extender. Perhaps the most common way of resetting UniFi access points is by physically pressing (with a light touch) the reset button on the back of the unit. C. 23. To produce white light, different color LEDs are combined or covered with a phosphor material that converts the color of the light to a familiar “white” light used in homes. The device has been adopted by the UniFi Protect Controller. Bought a Unifi Switch 8 60W, 8- port (4 POE) Ubiquiti switch. Lastly, power the USG and then the PoE switch and give it a couple of minutes for all 3 devices to start. Punched Border Switch Plates in Pewter-Black-Bronze-White. 1. Browse our wide selection of decorative wall plates to discover which style is best for your room. No lights or sounds Anywhere EXCEPT the little light beside the a. 3,099. Remember the moment where UNIFI users are complaining that they aren’t getting full Internet speed, even after UNIFI Turbo – which literally provides you 10 times faster speed. Each Unifi Switch will have a reset button on the back. Followed by a solid green (online). 8. When the system comes back up (solid white or blue light) you can connect to the USG again to verify that the firmware took. We recommend using a paperclip or other thin metal object to lightly press the reset button. Its ultra slim, low profile design (less than 1 in. Ubiquiti Networks networks Unifi switch 8-port 150 watts. Solid Amber Your Wi-Fi Gateway is powered on. Main Switch : UniFi US-24 (non POE switch) Will Run the bulk of the equipment in the house, PC, TV, Consoles etc 2. But there is more to it: Ubiquiti Networks networks Unifi switch 8-port 150 watts. Condition is "Used". The parts definitely work - I've tested them before and after the attempt to fix - and _should_ be compatible, although it won't hurt me to research for edge cases. The upgrade went smoothly with no apparent errors. They will come factory reset and ready to install. WAS $ 955. Charming light switch covers with popular images from America's favorite artists! Dozens of categories. No issues with the devices, just went a different way with my home network. Tried the manual reset on the back of the AP as well and tried another switch port. 4. 5 seconds white when booting, and is you did the reset properly should go to a steady white. 5TB NVME SSD's - 35" G-Sync 120hz 1440P. The Cisco SG112-24 unmanaged desktop switch delivers basic network connectivity and reliability for small businesses, without complexity. Once the AP has started and you have a solid light green/blue, try pressing the reset button on the back of the unit with a paperclip for 5–10 seconds. I've tried holding down the power button & Beats button together for 16. Redundant Power System UniFi SmartPower RPS, USP-RPS, is our PSU failover system. Once done, open up your UniFi controller and head over to “Devices”. Qty. When doing this, the PS button will turn the console on but then just be a solid white color after that. 39 (I believe that it was what it was on, it was 5. Our switches work perfectly in both residential and commercial settings. The UniFi Switch 8 150W is a fully managed PoE+ Gigabit switch, delivering robust performance and intelligent switching for enterprise networks. UAP-Pro stopped working (solid white light, no IP address?) I have 5 UAP-Pros set up in an office environment that have been working fine for the past 1. Outlet and light switch covers may not seem glamorous on their own, but with the right finish and style, electrical covers can tie any room together. sh restore-default and press enter on your keyboard. • Choose switch plates with a glossy finish if you're mounting them against flat paint so they stand out. reboot the router/switch etc that the mycloud is connected to. See the tables below for the description and meaning of the different system and port LED patterns. Ensure that you have chosen the right and qualified Cat. The B+P switches are made from solid metal and are available in five different finishes which match with our hardware & lighting ranges. Once the white light is steady, it is now in adoption mode. Hi all, I was playing a game earlier when randomly my controller decided to unsync and start flashing white. Custom light switch covers, or wall plates, outlet covers, decora switchplates, and all sorts of odd sized switch plates and receptacles in lots of different configurations. 3af/at protocol. Romani Blue, 40" Painted and Glazed Ceramic Body Table Lamp, 3-Way by StyleCraft Home Collection (1) SALE. v1. Wireless: Solid green LED that indicates the router is broadcasting Wi-Fi. Switch Hits' staff has criss-crossed the country many dozens of times to find you the world's largest selection of decorative wallplates in configuration you need! and the majority of them are in stock and can be shipped immediately. I think around 3-4 minutes. 0 EdgeSwitch (ES) firmware release, the device status LEDs have been improved to provide a more clearly defined state of the device. Here are some simple steps to follow when you want to physically factory reset a UniFi access point: Shop Legrand CO/ALR 15-Amp Single-Pole Framed Toggle Light Switch, White in the Light Switches department at Lowe's. Yesterday I upgraded the controller to 5. sh upgrade upgrade. Our instructions on how to wire a light switch for a standard light switch, a three-way light switch and a four-way Problem 1: Galaxy S6 edge won’t turn on, shows white solid LED light I have a Samsung Galaxy S6 edge. It took some time for the LED to turn from solid red to solid white. No Hub Required. Blue. 00 AUD. 5 out of 5 stars. You can factory reset an access point, switch or USG by depressing the small reset button with a paperclip on the back of the device. 13. Since then, I can not reboot or access the device (stuck in the white light LED). mtk7623. We tried on a Windows 10 computer and an iMac with no luck either way. If there's still no light, contact Wifi customer support. Once the reset has completed, the LED light will show as solid white/orange (depending on your model). • Don't be afraid to mix plain white switch plates for outlets with colorful or metallic switch plates for light switches. A. They usually light up white when booting up, then change to blue. Power Supply Failure In the event of a UniFi switch power supply failure, the USP-RPS automatically supplies redundant power to the failed device Ubiquiti UniFi 48 port Managed Gigabit Layer2 & Layer3 Switch - 48x Gigabit Ethernet Ports, 4x SFP+ Ports - Touch Display - GEN2. 4 GHz radio bands. Lee Hutchinson - Apr 13, 2016 11:30 Below you will find the correct way to reset an Unifi Switch and also a couple of tips for when the adoption won’t succeed. Unifi Enterprise Switches This can be found on the settings page on the controller as shown below. Light Switch Cover, Light Switch Plate, Cast Iron Switch Cover, Farmhouse Kitchen Decor, Cast Iron Light Covers, Fleur De Lis Rustic Decor. Victorian Decorative Triple Gang Switch & Electrical Outlet Plug Combo Switchplate Cover (L-W24) Price: $29. The computer and server will be connected hardwired so, they’ll be on ports 3 and 4. 192. 26 offers from $54. Punched Heart Design Switch Plates in Pewter, White, Brass. The device is booting up. Ubiquiti Unifi Security Enterprise Gateway Router with Gigabit Ethernet. Switchplate Gallery Common LED colors include amber, red, green, and blue. Set your smart light switch to turn connected fixtures on and off at random intervals to give the appearance you're home even while you're away. Please upgrade your browser to improve your experience. Manufacturer: Ubiquiti Networks, Inc. 5 or above Ethernet cable and plug into the right port on the PD. ) is perfect for any low ceiling area and the no glare, edge-lit LEDs are integrated so It may seem a bit strange that we’re turning on the light as the action here when we already know its on, but it was the most straight forward way I could find to set the brightness on the light strip. And here’s what that looks like in your UniFi Controller Software. Pass & Seymour TradeMaster® toggle switches combines a traditional look with reliable, time-tested operation for any residential application. No need for a hub or extra equipment. I manage 33 sites with Unifi Cloud Key Controllers. It will turn solid green when the Mesh network has been created. how long has it been setting with a white light? after a crash (power failure etc) it could take a very long time to come back. Phosphor is a yellowish material that covers some LEDs. But there is more to it: Lorthremar 1 year ago #1. Filters. It supports 1080p and 4K UniFi Security Gateway which Is a wired router and FireWall, and it is older and slower than UDM, UniFi Cloud Key – this is a controller allows you to manage all of your network equipment, Also a 4-ports switch – The closest one is the 5 port switch or 8-port switch, Ubiquiti’s 8-port POE switch is a solid complement for a home Unifi setup Fanless $199 managed device drives Unifi Wi-Fi gear—if you can find it in stock. You are using an outdated browser. Unifi Turbo – Replace Your Router. The AP boots up and goes solid white, so I think I'm ready to go, but the controller (installed on my server) does not see it. plug stays solid white at all times even when not plugged in. seconds and power/more buttons for 15 seconds, both plugged in and unplugged.


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ATHENS – Athens’ municipal council approved the capital’s budget for 2023 on Monday.
The plan foresees revenues of over 1 billion euros (from 917.6 in 2022), an increase of investments by 153% compared to 2019 (to 174.93 million euros), and funded projects worth 510 million euros (funded by European and national resources). Nearly 106 million euros are allocated to technical improvements, including roadworks and rain drainage projects, including at the Eleonas neighborhood, as well as biomaterials sorting at source.
Athens Mayor Kostas Bakoyiannis also reiterated an earlier announcement, that the city is reducing cleaning and lighting fees by 5%.
He explained that the increase in revenues foreseen comes from already using digital services, improving automated programs, and putting into operation e-payment programs. “These actions have allowed us to guarantee the operationability of revenue collection for everyone without exception. They led us to ensure (we get) something from the many, not to ask much from the few.”
Revenues are rising at 22.4% and liquidity remains high (45-50 million euros). “These are fully confirmed by the last report of Moody’s on October 20, 2022, which stresses our city’s excellent economic state, its prudent management, and the low debt rate compared to other local governments in Europe,” the mayor said.


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domain: hobby