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Almonds contain a lot of healthy fats, fiber, protein, magnesium, and vitamin a, which is the health of almonds include a blood glucose reduction, lower blood pressure and lower cholesterol levels. They can also reduce hunger and promote weight loss.
Studies show that foods rich in vitamin E increase the production of sex hormones. Almonds have a lot of vitamin E, including all of the nuts, and seeds. Dark chocolate promotes the release of serotonin and endorphins. These are chemicals that are used to improve the condition of their skin, the mood, the feeling, which increase men’s sexual pleasure.
Benefits of Almonds for Men
Almonds can help with testosterone
One of the advantages of almonds, for men, it can be a nut is a high zinc content. (Nuts are also a rich source for normal and combination skin.) Zinc, an essential nutrient for the production of testosterone. And even though testosterone is the most important thing follicular hormone on the part of men’s and women’s, and now we know that the effects of low testosterone levels in a man can be sharp and erectile dysfunction (ed).
So, I probably didn’t think that the zinc contained in almonds and other nuts can help to promote the production of testosterone naturally.
However, nutrition experts say, is that the development reflects the point of view. Since the nuts are a source of polyunsaturated fatty acids, there is a fear that the frequent use of some tree nuts, including almonds lower testosterone levels. This is because some of the studies show that polyunsaturated fatty acids can lower the levels of testosterone.
However, the consensus among nutrition experts seems to be that ” more research is needed to determine if the almonds, can lead to low testosterone levels in men.
The Extra nutrients in almonds, maintain the sexual health
Almonds and nuts are better sources of selenium food that is good for men’s sexual health. Selenium is important for the sperm’s activity. However, there is evidence that selenium deficiency may adversely affect the level of sexual desire. Since the harness is best obtained from a natural source and supplements, and almonds, are an excellent choice to provide your body with essential nutrients.
And, as I have already noted, in the context of the application, the almond is a great source of plant protein. With each quarter of a cup containing up to 10% of the recommended daily intake of protein. (However, keep in mind that physical activity, among other things, the passion of the nights, requires extra protein.) However, 10% is not a bad thing to have a delicious and portable snack!
Of course, if you’re really not a fan of nuts, but would still like to get the benefits of almonds for men you can try out the nuts. As I noted above, nuts have the same properties as almonds.
The other way to get the nutritional benefits of almonds for men’s health
If raw or roasted almonds are not your cup of tea, think the almond butter. You can also try almond milk, but the benefits of almond milk aren’t as impressive as what you can get directly on the almonds.
The benefits of almonds for men can also be enjoyed by using almond flour. Its made by blanching the almonds to remove their skins then grinding them to the texture of fine flour. Almond flour has almost all the nutritional benefits of whole almonds, only without the crunch.


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David Chaum Announces xx coin
It was reported on PRNewsWire that David Chaum, a cryptography pioneer, announced that the xx coin (digital currency) will be supporting decentralized messaging, payments and DApps across the xx network.
“The xx coin and xx network will serve smartphone users and dApp developers by harnessing both the metadata-shredding anonymity and privacy of Elixxir and the security, speed and scalability of Praxxis,” said Chaum. “By successfully bringing the projects together, the xx network resolves the tension between speed/scale and privacy/security.”
Early supporters of the xx collective will be eligible for certain benefits on the xx network. The network was developed to answer people’s demand for privacy. It currently supports the following: the xx messenger and an Elixxir dApp.
“For all of us to feel comfortable online with the more important and sometimes sensitive parts of our lives, we need money with financial privacy and security to conduct our affairs,” said William Carter, COO of Praxxis. “And to support users worldwide we need low-latency, high-speed performance at scale. The xx coin provides a way for Praxxis and Elixxir software to achieve these goals running on the decentralized xx network. Next step is beta!”

domain: news


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It looks like everyone's favorite time-traveling misfits could be slated to meet up with yet another Hollywood icon. The third season of DC's Legends of Tomorrow is currently in production, and series creator Marc Guggenheim is keen to remind fans that the show is coming back sooner than later.
Guggenheim tweeted out a photo of a script from the season's fourth episode, titled "Phone Home," which is written by Matthew Maala and directed by Kevin Mock. Of course, film fans of all types will know the title references the classic 1982 Steven Spielberg film E.T.: The Extra Terrestrial.
Legends' second season saw the eponymous hero team travel back in time to ensure George Lucas creates the Star Wars and Indiana Jones franchises, making the episode a fan-favorite. The E.T. reference this time around has led some fans to theorize that viewers are in for another bout of nostalgia, this time of the Spielbergian variety.
The episode could just draw thematic elements from the film, like unlikely friendships or the sense of being lost in an alien place, but there's always hope that "Phone Home" will include flying bicycles or something about Indiana Jones.
Returning to the CW for its third season on October 10, DC's Legends of Tomorrow is a production of Berlanti Productions developed for television by Greg Berlanti, Marc Guggenheim, Andrew Kreisberg and Phil Klemmer and starring Victor Garber, Brandon Routh, Arthur Darvill, Caity Lotz, Franz Drameh, Ciara Renée, Falk Hentschel, Amy Pemberton, Dominic Purcell, Wentworth Miller, Matt Letscher, Maisie Richardson-Sellers and Nick Zano.

domain: entertainment


Yuba Kombi E5 Cargo eBike
The Kombi E5 is Yuba's most affordable electric cargo bike, but make no mistake, it's a high quality machine, designed to carry your passengers and assorted cargo for the long run.
The Kombi E5 is powered by a Shimano STEPS E5000 mid-drive system, amplifying your pedaling so you can cruise with assist up to 20 mph, and comes standard with 9-speed drivetrain and hydraulic disk brakes, providing solid reliability and easy maintenance. And at only 65 lbs, it's one of the lightest cargobikes in its class, handling as comfortably as much smaller bikes.
We have a range of cargo and passenger accesories from Yuba, too. Come down to the Hub for a test ride and demonstration today!


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Congratulations to Theresa Ditson for winning the recent Summer Storms Assignment with the image, Anticipation.
“‘Anticipation:’ Suspense master Alfred Hitchcock has said, ‘There is no terror in the bang; only in the anticipation of it,'” says Ditson. “I watched this weather system in Prescott, Arizona, start out quite small and suddenly progress to a swirling massive cloud dropping lightning bolts and approaching my direction. For a brief moment, the edge of the cloud took on a subtle fuchsia hue as the sun was setting opposite but was partially blocked by clouds in its own direction, creating a surreal effect to the ambient light that was atypical of any other sunset colors I had seen. For this brief moment of anticipation, the wind stood still and all seemed almost falsely calm, and I actually thought the storm was going to die out before it would escalate any further. But then I heard it— as if having taken one deep breath, held it for a moment, then finally exhaled with full force, the wind picked up in front of me, the leaves in the trees behind me trembled and quaked audibly, and suddenly all fury broke loose! I could not even pack my camera away; I just put the cap on and ran with the tripod at my side but still fully extended, the rain and wind blasting me sideways and into my ear. I finally made it back to my vehicle, thoroughly drenched, and remembered countless other similar experiences I had been through—all part of trying to capture the monsoons over the years. I hope you enjoy.”
Check out our current photography assignment here and enter your best shots!

domain: hobby


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Chronic allograft injury (CAI) is the leading cause of kidney transplant failure, manifesting as progressive tubulointerstitial fibrosis and atrophy (IFTA): inevitably increasing during the life of the allograft, adversely influencing graft function and survival (1, 2). It has been hypothesized that IFTA is the result of a natural equilibrium imbalance in collagen deposition and remodeling/removal, toward increased collagen deposition by activation of myofibroblasts in response to tissue injury. The cause of CAI is yet to be elucidated, but it is generally accepted to be a reflection of the nonspecific end pathway of tubular cell injury in response to various immune and nonimmune insults (2, 3). A postulated mechanism of CAI in the renal allograft is through epithelial-to-mesenchymal transition (EMT)—where the tubular epithelial cells transition into interstitial myofibroblasts. Because myofibroblasts are central to renal fibrosis, their origin and activation forms a crucial component of the axis of progressive IFTA.
In the kidney, the postulated events of EMT begins with the loss of epithelial markers (E-cadherin) and function, migration into the extracellular space and morphosis into a myofibroblast (α-smooth muscle actin [SMA] positive), ending with secretion of matrix proteins (collagens) and initiation of renal fibrosis (4–8). The role of EMT in renal fibrosis is contentious with a number of in vivo studies proposing it as a major mechanism of damage (8–10), whereas others as minor or unrelated to fibrosis (11–14). Most agree on the occurrence of EMT in the kidney, with in vitro studies proving the ability of a tubular epithelial cell to transition into a fibroblast under ideal conditions (6, 11, 15, 16), thus fueling the EMT-renal fibrosis association hypothesis, with key issues being mechanism driving EMT and its degree of overall fibrotic effect in vivo. Unfortunately, most studies into renal EMT have been performed in animal models, cells lines, or adult in vivo clinical investigations, thus neglecting pediatric transplantation. This study is the first of its kind, in attempt to shed light on the role of EMT in pediatric transplantation, specifically looking at the molecular responses during the adaptation of an adult-sized renal allograft in size discrepant, young pediatric recipients. This study combines focused microarray analysis and histology of 126 posttransplant renal biopsies at 3, 6, 12, and 24 months from 83 thoroughly clinically categorized pediatric renal transplant recipients.
Study recipients were 10.8±6.4 years old, of which 64% were men with a body surface area (BSA) of 1.1±0.5 m2 at implantation. The donor age was 32.8±10.7 years, of which 47% were men with 28% of allografts originating from deceased donors. The average human leukocyte antigen mismatch score was 4.1±1.4 with a cold ischemic time of 198±252 min. This was an immunologically pristine dataset that excluded patients with cases of delayed graft function and interval acute rejection. Immunosuppression consisted of induction with daclizumab, followed by maintenance on mycophenolate mofetil and tacrolimus in combination with steroids (n=16) or without (n=67). Finally, none of the allograft recipients developed recurrent primary renal disease, BK tubulointerstitial nephropathy, or infections.
Progressive IFTA in Pediatric Recipients of Adult Renal Allografts Is Driven by Allograft Size Mismatch, Ongoing Calcineurin Inhibitor Toxicity, and Immune Injury
This data set has minimal impact on donor-derived morbidity in the development of CAI because all allograft recipients had a Remuzzi score less than 1 on their implantation biopsy. As expected and as shown previously by our group (17), time posttransplantation was the greatest correlate (r=0.78, P<0.001) of increasing chronic allograft damage index (CADI) and calcineurin inhibitor toxicity (CNIT) scores over the 24-month period of study (mean: 24 months, CADI score: 4.4±2.7; mean: 24 months, CNIT score: 5.1±6.7). In addition, we observed a steady increase in the total i score over time, from 18% of biopsies at 3 months with a total i more than 1 to 37% at 6 months, 62% at 12 months, and 71% at 24 months, which correlated with increasing tubulointerstitial damage (TID; r=0.66, P<0.001). Stratifying patients by BSA, we found, similar to our previous publication (17), that children with the lowest BSA (<0.75 m2) had progressive and significant IFTA (r=0.52, P=0.001) and CADI (r=0.37, P=0.05) injury over the first 2 years. Using logistic regression (odds probability), we found that the total i score, CNIT score, and low BSA at implantation were the main risk factors (Fig. 1) for chronic and progressive no-immune graft injury.
Enrichment of EMT-Associated Genes
To assess the influence of EMT on CAI, we performed an intersection comparison of the differentially expressed genes (DEGs) in relation to CAI on biopsy; with the 243 EMT-associated gene set (Fig. 2; see Table, SDC 1,http://links.lww.com/TP/A483 ). From these CAI DEGs (details in Ref. 18), there was enrichment (P=0.05) of EMT-associated genes (n=13), such as TGFβR2, NOTCH2, MMP7, VIM, indicating that EMT may play a role in progressive IFTA (data shown in SDC 2,http://links.lww.com/TP/A484).
To further investigate the specific influence of EMT on CAI, we filtered the microarrays using the 243 EMT- associated gene set and compared CAI versus no-CAI on biopsy (Fig. 3, Table 1; see SDC 3,http://links.lww.com/TP/A485, SDC 4, http://links.lww.com/TP/A486, and SDC 5,http://links.lww.com/TP/A487) at the various time points. The first analysis at 3 months identified 48 DEGs (see Table, SDC 3,http://links.lww.com/TP/A485), with 36 upregulated and 12 downregulated genes. A number of these DEGs represent EMT regulators, such as SMURF1 and 2, NOTCH2, SMAD2 and 6, TGFβ3, BMP1 and 2, FGFR1 and 2, and SKI (Table 1). The EMT profile of gene expression seems to suggest a pro-EMT pattern, with the majority of above- mentioned genes upregulated in the absence of pro– mesenchymal-to-epithelial transition (MET). This EMT association with early CAI is further evident from its separation from no-CAI at 3 months (Fig. 3B). One of the differentially expressed EMT-related genes were validated (MMP2) by quantitative polymerase chain reaction (QPCR) in an independent cohort of 3-month protocol biopsies that had presence of CAI (n=6) or absence of CAI (n=6). We selected MMP2 as a DEG in CAI at 3 months because it has been recognized to play a role in EMT and has a q score in the microarray data set of 5.39 and a false discovery rate of less than 5%. MMP2 was observed to be similarly upregulated through QPCR with significant increase in transcription for CAI (P=0.03) (see SDC 2,http://links.lww.com/TP/A484).
The EMT pattern at 6 months differed, with 10 of the 47 DEGs (all upregulated) in CAI were common to 3 months (Fig. 3A, Table 1; see Table, SDC 4,http://links.lww.com/TP/A486). The EMT expression in CAI at 6 months continues to be pro-EMT with the upregulation of AKT1, SMURF1, BMP1 and 2, SMAD3, FGFR1, and TIMP1. Unlike at 3 months, hierarchical clustering was unable to distinctly separate CAI from no-CAI (Fig. 3C), indicating additional mechanisms influencing the development of CAI at 6 months posttransplant.
There seems to be a time course to EMT-related genes expression, with majority and strongest EMT molecular changes occurring early posttransplant time course (3 and 6 months) with the absence of any EMT-related DEGs at 12 months. There was late resurgence of EMT gene expression at 24 months with 24 DEGs EMT genes, 10 upregulated and 14 downregulated (Table 1; see Table, SDC 5,http://links.lww.com/TP/A487). In addition, a pro-MET pattern appeared with an upregulation of hepatocyte growth factor (HGF) and downregulation of epidermal growth factor and insulin-like growth factor 1 receptor. A number of the pro-EMT genes (TCF4, WNT5A, VCAN, and IL1RN) also play a role in B-cell signaling and differentiation, supporting our previous findings of a subtle immune injury in the absence of overt rejection episodes. Hierarchical clustering was unable to separate CAI from no-CAI (Fig. 3D).
CNIT and Overall Immune Burden Promotes Early EMT in CAI, Pro-MET Late to Combat Immune Injury
To elucidate the mechanisms and role of EMT-related genes at each defined posttransplant time point, Spearman's rank correlations were performed against the main histopathologic (total i and CNIT) and demographical (BSA and recipient age) drivers of CAI (Table 2; for DEGs, see SDC 3,http://links.lww.com/TP/A485, SDC 4,http://links.lww.com/TP/A486, and SDC 5,http://links.lww.com/TP/A487).
We observed that the majority (96%) of the EMT DEGs significantly correlated with the degree of interstitial fibrosis, as indicated by the Banff ci score, early posttransplant (3 months) with a pro-EMT pattern (Table 2; see Table, SDC 6,http://links.lww.com/TP/A488). In addition, it seems that both the total interstitial lymphocytic infiltrate (total i) and CNIT are contributing to the pro-EMT signal at 3 months with 23% and 19% of EMT DEGs significantly correlated, respectively (Table 2). Each pathologic entity seems to influence different EMT genes with the total i positively correlating with such pro-EMT genes as SMAD2, TGFβ3, MMP2, FGF18, and FGFR1. CNIT correlated positively with pro-EMT genes such as insulin-like growth factor 1 receptor, MITF, and SMAD9. Interestingly, it seems that small (BSA) young recipients are somewhat protected against the pro-EMT gene expression as seen by their significant correlations contrary to what one would expect. This is exhibited by the significant negative correlations against some major pro-EMT such as BMP1, JAG1, NOTCH3, and MITF and similar trends in SMAD2, SMAD9, SKI, RAC1, and MMP2 with young recipients and positive correlations of the same genes with larger recipients (see Table, SDC 6,http://links.lww.com/TP/A488).
Unlike at 3 months, there were no significantly correlated EMT genes at 6 and 24 months with Banff ci, BSA or recipient age, although the Banff total i score was the main group that correlated with EMT gene expression (17%), with positive correlations toward a number of mitogen-activated protein kinases (MAPKs), integrins, and TIMP1, which may represent local immune-related mechanisms in an injured graft (Table 2; see Table, SDC 6,http://links.lww.com/TP/A488).
EMT genes that were significantly correlated with the total infiltrate at 24 months were IL1B, IL1RN, VCAN, and ITGAX (Table 2; see Table, SDC 6,http://links.lww.com/TP/A488). In addition, the major pro-MET gene HGF was positively correlated with the total infiltrate, suggesting an active attempt to reverse or counteract the immune-directed injury. This is also evident from its significant correlation with increasing interstitial fibrosis, further suggesting an attempt of the allograft to respond to the injury burden.
Decreased E-Cadherin Staining (CDH1) in Patients With CAI
We performed IHC staining for E-cadherin (CDH1; see SDC 2, http://links.lww.com/TP/A484) to assess for loss of E-cadherin staining in CAI. We observed a significant decrease in the number of CDH1-positive-only cells (see Figure, SDC 2,http://links.lww.com/TP/A484) in the tubules of biopsies with CAI compared with no-CAI biopsies (P=0.04, 132.9±38.6 vs. 161.4±16.4 per high-power field, respectively). The decrease in CDH1 staining can be considered a reflection of tubular injury and tubular epithelial cell loss, which is the first stage of the EMT mechanism and a measure of EMT.
This is the first and largest study to date to investigate the role of EMT in the evolution of CAI in pediatric recipients of adult-sized, stable renal allografts, without the influence of acute renal allograft rejection, which in itself is a major player in the progression of CAI. Not unlike the adult kidney transplant population, CAI is one of the largest causes of allograft failure, manifesting itself as indiscriminate IFTA (1, 2). This study demonstrates that the EMT-MET equilibrium is a potential key mechanism used by the allograft in the development or response to the evolution of chronic injury. We observed an enrichment of EMT-associated genes in protocol transplant kidney biopsies exhibiting phenotypic signs of TID using whole transcriptome analysis with microarrays. To elucidate the role of EMT, we interrogated the performance of a selected panel of 243 EMT-related genes using whole genome biopsy transcriptome analysis, semiquantitative histopathologic analysis of Banff, CADI and CNIT biopsy scores, and patient clinical and demographic data. From this focused analysis, we observed a time-dependent expression of EMT-related genes in CAI, with a prominent early (3–6 months) stage and resurgent late (24 months) stage, relating to tissue remodeling in response to allograft injury. The major confounders associated with the early pro-EMT response in the allograft are molecular markers of immune injury and CNIT biopsy scores. A counter-EMT response is enriched in young recipients of an adult-sized kidney, with low BSA (<0.75 m2), suggesting a confounding effect of natural developmental biology in young recipients (<6 years). A counter-EMT pattern of expression was observed late posttransplant (24 months) as indicated by increased expression of HGF, a known inducer of MET (19, 20), which is associated with interstitial fibrosis and infiltrating immune cells. Our study using a combination of whole genome transcription analysis, histopathology, and clinical data was able to determine that EMT has a role in early allograft injury and fibrosis, with the allograft appearing to use the reciprocal pathway of MET to counteract and repair damage caused by chronic immune and CNIT injury.
As we have shown in previous studies, allograft size mismatch in the form of adult size allografts transplanted into small pediatric recipients is a major risk factor and driving force for accelerated CAI and allograft dysfunction (17, 21–24). The rationale behind this phenomenon is of chronic ischemic injury to the allograft as a result of reduced perfusion by the recipients smaller cardiac output compared with that of its healthy adult donor. This ischemic injury leads to the release of the full plethora of injury mechanisms resulting in TID, which combined with the other standard immune and nonimmune drivers of CAI results in an accelerated process and further reduced allograft survival (17). This study supports our previous findings where low BSA of the recipient presented as the major demographic risk factor (hazard odds ratio of 2.0) for the presence of CAI on biopsy. In addition to the ischemic injury, this study is consistent with our previously published work and others in the adult setting, where both the total immune burden and CNIT are also critical driving forces to CAI with an increased hazard ratio of 11.5 and 2.5, respectively (3, 25–28).
EMT is a critical process of embryogenesis during specific phases throughout metazoan development and formation of organs, limbs, and other specialized structures. The formation of these various structures is based on the creation of mesenchymal cells from an epithelia progenitor cell type, hence EMT. These de novo mesenchymal cells allow migration into and through the extracellular environment, settling in areas where organ development is to occur. This process is reversed once these mesenchymal cells have settled; forming epithelial-based organs through MET. Both EMT and MET are used to form the kidney during embryogenesis and development (29, 30) and are in equilibrium. For EMT to commence and be maintained to completion, a number of major and profound changes in the surrounding microenvironment and epithelial cell organization must occur. These changes occur in six rate-limiting steps, as outlined by Baum et al. (31), where malfunction at any stage leads to EMT unable to proceed.
We observed two distinct phases of EMT/MET-related expression following the pattern of allograft injury (17, 18), one early pro-EMT (0–6 months) and one late mixed pro-EMT/pro-MET (12–24 months). Early posttransplant (0–6 months), saw the upregulation of pro-EMT genes (Table 1), with the majority of these EMT-related genes correlated strongly with early IFTA, CNIT, and overall immune burden (Table 2), distinguishing CAI from no-CAI with supervised hierarchical clustering at 3 months, abet four miss classifiers (Fig. 3B). Contrary to expectation, pro-EMT gene expression did not associate with prolonged ischemic injury as represented by organ-recipient size mismatch disparity. One possible explanation is the general biology of the younger recipients may be causing a dampening or counteraction of EMT mechanisms because of normal renal development. This would require further investigation to elucidate the influence of recipient age on EMT mechanisms, including a young to young control group, which unfortunately was not possible in the current study.
The phenotypical transition from an epithelial cell to a mesenchymal cell through the process of EMT is a complex and dramatic cascade of events that requires a great deal of both transcriptomic and structural changes to occur successfully. With this being the case, there are a number of key pathways and genes that are top-end regulators of EMT: some of which are TGF-β, E-cadherin, Snail, and Twist as shown in studies of organ development, cancer, and fibrosis (4, 32–34). As with many of EMT-associated genes, they have many different roles such as TIMP1, MMPs, and collagen in breakdown and extracellular matrix remodeling. Others are involved in proliferation and dedifferentiation, such as SMAD2 and HGF, respectively, with some playing dual roles depending on the situation, such as TGFβ3. This is probably the main cause of contrasting opinions with the role of EMT fibrosis (8–14); however, most agree that EMT is present posttransplant. In a previous adult-based study (12), EMT may play a minor role in CAI, with this current study showing that EMT potentially playing a larger role in early pediatric transplantation. This discrepancy between age-confounded studies is not uncommon as we have seen previously in transcriptome analysis of acute rejection in renal allografts, with only 16% of the pediatric-derived DEGs common with adults (35), likely because of differences in immunobiology, population, array platform, and other demographic variables.
The second stage of EMT/MET was observed through the disappearance of EMT-related mechanisms between the 6- and 24-month posttransplant period and low resurgence at 24 months. This indicates a potential shift in the mechanisms influencing EMT or a transitional point in EMT signaling, thus suggesting a late phase of MET-related mechanisms. This absence of EMT-related expression was observed despite continuous increase in allograft injury, potentially reflecting the overall net effect of mRNA message in tissue samples in an attempt to maintain the EMT-MET equilibrium. This can be postulated as evidence of epithelial-mesenchymal-epithelial (EME) cycling of the allograft to counteract the rampant uncontrolled healing response to early injury.
EME cycling is a process where an injured epithelial cell transitions into a mesenchymal cell by means of EMT, then reverting back to an epithelial cell once the damage is repaired. This process is postulated to occur naturally in the kidney, with evidence deriving from various studies in vivo of acute tubular necrosis (36, 37) and the presence of EMT in healthy kidney donor biopsies (12). The process of EME allows epithelial cells to migrate to damaged tubules, where they back-differentiate, proliferate, and repopulate it (38–40). Many of the same markers implicated in EMT are associated with the dedifferentiation and migration of the epithelial cells, including TGF-β1, vascular endothelial growth factor, HGF, epidermal growth factor, and various others (41–43). Redifferentiation and back conversion of these cells to form a tubule requires the absence of the EMT-inducing markers and cell-cell contact to be re-established, one such maker being HGF (40) with MAPKs playing a major role (44, 45).
We observed a gene expression pattern which suggests EME cycling is ongoing in retaliation to chronic immune injury and initial ischemic insult of the allograft, as seen by the DEG and positive correlations of HGF in late biopsies with IFTA. This hypothesis is supported by the absence of the major pro-EMT genes that were observed earlier during the combination of injury mechanisms CNIT, ischemia, and immune-related processes. The late pro-MET–related gene expression may be an indication of the allografts response to this ongoing allograft injury. One may go further and postulate that the allograft uses some of the EMT observed at this late stage in the process of EME cycling to counteract the immune and ischemic injury, the two significant drivers of fibrosis (17) and EMT (6, 11), as supported by the correlation HGF and MAPKs and minor EMT-related genes late. With this said, a more comprehensive focused study into the role and mechanisms of EME cycling in renal transplantation is required to elucidate and validate this working hypothesis on the allografts response to chronic injury.
In conclusion, we observed an enrichment of EMT-related gene expression in our pediatric recipients of an adult allograft with consistent and gradual CAI. We were able to elucidate somewhat the role of EMT in relation to the progressive immune, CNIT, and ischemic-based injury as the allografts response to such, in an attempt to counteract and repair itself. We postulate that this is mediated through the natural EME cycling equilibrium, where the allograft attempts to shift this equilibrium in favor of healing, over fibrosis.
MATERIALS AND METHODS
Study Population and Patient Samples
The study consisted of longitudinal surveillance biopsies from pediatric recipients of an adult kidney transplant from 2004 to 2006 at Lucile Packard Children's Hospital at Stanford. All patients received induction with daclizumab and maintenance immunosuppression with tacrolimus, mycophenolate mofetil, with or without steroid avoidance (46, 47); all included patients in the study had excellent and immediate graft function, and there were no patients with delayed graft function in this study. All the samples were taken at immunologic quiescent phase with no Banff gradable acute rejection. With this study design, any confounding influence of DGF and interval acute rejection were controlled for, allowing for a clean analysis of EMT-related transcriptional changes in the development of CAI. The study was approved by the Ethics Committee of Stanford University Medical School, and all patients/guardians provided informed consent to participate in the research, in full adherence to the Declaration of Helsinki. As per Stanford institutional review board–approved protocol, biopsies were collected (see Methods, SDC 2,http://links.lww.com/TP/A484) at 3 (n=20), 6 (n=45), 12 (n=19), and 24 (n=42) months posttransplant. Full clinical details matched at the time of biopsy were collected on all participating patients.
Histopathology and CAI Definition
All biopsies collected were blindly scored by a single pathologist at Stanford (Neeraja Kambham) according to Banff criteria (48–50), with all biopsies given a CADI (51), CNIT (52), and IFTA/TID score additional to Banff diagnosis. Biopsies were scored semiquantitatively for both chronic and acute injury, as per standard Banff schema (48–50) and a CADI score of more than 5 defined a biopsy as exhibiting signs of significant CAI (previously CAN), as described in our previous publication (18). For comparative analysis, the non-CAI group was chosen to include subjects with biopsies not showing any significant chronic injury (CADI score <1) over the first 2 years posttransplant.
RNA Extraction and Microarrays
From each tissue biopsy, total RNA was extracted, quantitatively and qualitatively measured, and hybridized to Affymetrix GeneChip Human Genome U133 Plus 2.0 Arrays as previously described in Naesens et al. (18) and summarized in SDC 2, Methods and Results,http://links.lww.com/TP/A484.
EMT Gene Set Analysis
A selected group of EMT-associated genes were chosen on two criteria: (1) genes identified in the published literature to play a role in EMT and renal injury and EMT signaling cascades (see Table, SDC 1,http://links.lww.com/TP/A483); and (2) genes ascertained to play a role in EMT in chronic injury in adult kidney transplantation (12). This resulted in 247 individual discrete annotated genes (643 Affymetrix-designed probe sets), through AILUN (53).
Microarray and Pathway Analysis
The microarrays were normalized and analyzed using standard statistical and bioinformatic tools, such as R, Bioconductor, significance analysis of microarrays, ingenuity pathway analysis, and hierarchical clustering as described by Naesens et al. (18) and summarized in the Methods, SDC 2,http://links.lww.com/TP/A484.
QPCR was performed on an independent cohort of 12 patients on their 3-month protocol biopsy to validate MMP2 (important deferentially expressed EMT gene) using one house keeping gene (GAPD) as an endogenous control. Reverse transcription and cDNA synthesis was performed using the Superscript III following the manufactures protocol (Invitrogen, Carlsbad, CA). The quantitative real-time polymerase chain reaction was performed using SYBR Green chemistry as previously described (54), comparing the ratio of expression of CAI over no-CAI, as calculated in the microarrays (see Methods and Results, SDC 2,http://links.lww.com/TP/A484).
Immunohistochemistry Staining for E-cadherin (CDH1)
Staining for EMT-related tubular injury was performed using the standard epithelial marker CDH1 on an independent cohort of 12 patients on 3-month protocol biopsy. The immunohistochemistry was performed using standard techniques as previously described (12). In brief, 3-μm-thick sections from formalin-fixed paraffin-embedded tissue renal biopsies were dewaxed and treated for antigen retrieval, and endogenous peroxidases were blocked. CDH1 (clone ECH-6, Ventana, Tucson, AZ) was stained and visualized, all on an automated immunostainer (Ventana). Single stained CDH1-positive tubular cells were counted and averaged over three randomly chosen high-power fields (600×) per biopsy by a blinded observer to clinical phenotype.
Normalized gene expression values from biopsy microarrays were assessed for various statistical correlations and assessment with transplant variables, with a P value of less than 0.05 considered significant for all analyses (see Methods, SDC 2,http://links.lww.com/TP/A484).
The Sarwal Lab thanks all of the patients and families for their support in this research. The authors thank Neeraja Kambham for her pathologic assessment and scoring of the transplant biopsies for Banff criteria. Matthew Vitalone specifically thanks the Lucile Packard Foundation for Children's Health and the Stanford CTSA (UL1RR025744) for providing fellowship funds to complete this research and his wife Laurice for her love and support.
1.Nankivell BJ, Borrows RJ, Fung CL, et al. The natural history of chronic allograft nephropathy. N Engl J Med
2003; 349: 2326.
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2001; 71: 515.
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2001; 159: 1465.
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10.Djamali A, Reese S, Oberley T, et al. Heat shock protein 27 in chronic allograft nephropathy: A local stress response. Transplantation
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. J Am Soc Nephrol
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13.Duffield JS. Epithelial to mesenchymal transition in injury of solid organs: Fact or artifact? Gastroenterology
2010; 139: 1081, 1083 e1.
14.Callahan KL, Beck NK, Duffield EA, et al. Inactivation of methicillin-resistant Staphylococcus aureus
(MRSA) and vancomycin-resistant Enterococcus faecium
(VRE) on various environmental surfaces by mist application of a stabilized chlorine dioxide and quaternary ammonium compound-based disinfectant. J Occup Environ Hyg
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15.McMorrow T, Gaffney MM, Slattery C, et al. Cyclosporine A induced epithelial-mesenchymal transition in human renal proximal tubular epithelial cells. Nephrol Dial Transplant
2005; 20: 2215.
16.Slattery C, Campbell E, McMorrow T, et al. Cyclosporine A-induced renal fibrosis: A role for epithelial-mesenchymal transition. Am J Pathol
2005; 167: 395.
17.Naesens M, Kambham N, Concepcion W, et al. The evolution of nonimmune histological injury and its clinical relevance in adult-sized kidney grafts in pediatric recipients. Am J Transplant
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18.Naesens M, et al. Microarray expression profiling associates progressive histological damage of renal allografts with innate and adaptive immunity. Kidney Int
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19.Dai C, Liu Y. Hepatocyte growth factor antagonizes the profibrotic action of TGF-beta1 in mesangial cells by stabilizing Smad transcriptional corepressor TGIF. J Am Soc Nephrol
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20.Deuse T, Peter C, Fedak PW, et al. Hepatocyte growth factor or vascular endothelial growth factor gene transfer maximizes mesenchymal stem cell-based myocardial salvage after acute myocardial infarction. Circulation
2009; 120(11 suppl): S247.
21.Salvatierra O, Concepcion W, Sarwal M. A critical look at the immunologically favorable adult-sized kidney transplant in small children. Pediatr Transplant
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22.Salvatierra O Jr, Sarwal M. Renal perfusion in infant recipients of adult-sized kidneys is a critical risk factor. Transplantation
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23.Salvatierra O Jr, Singh T, Shifrin R, et al. Successful transplantation of adult-sized kidneys into infants requires maintenance of high aortic blood flow. Transplantation
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24.Salvatierra O Jr, Singh T, Shifrin R, et al. Transplantation of adult-sized kidneys into infants induces major blood flow changes. Transplant Proc
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25.Nankivell BJ, Borrows RJ, Fung CL, et al. Calcineurin inhibitor nephrotoxicity: Longitudinal assessment by protocol histology. Transplantation
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28.Mengel M, Reeve J, Bunnag S, et al. Scoring total inflammation is superior to the current Banff inflammation score in predicting outcome and the degree of molecular disturbance in renal allografts. Am J Transplant
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29.Barasch J, Yang J, Ware CB, et al. Mesenchymal to epithelial conversion in rat metanephros is induced by LIF. Cell
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31.Baum B, Settleman J, Quinlan MP. Transitions between epithelial and mesenchymal states in development and disease. Semin Cell Dev Biol
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34.Barrallo-Gimeno A, Nieto MA. The Snail genes as inducers of cell movement and survival: Implications in development and cancer. Development
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35.Chen R, Sigdel TK, Li L, et al. Differentially expressed RNA from public microarray data identifies serum protein biomarkers for cross-organ transplant rejection and other conditions. PLoS Comput Biol
2010; 6: pii: e1000940.
36.Bonventre JV. Dedifferentiation and proliferation of surviving epithelial cells in acute renal failure. J Am Soc Nephrol
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38.Ishibe S, Cantley LG. Epithelial-mesenchymal-epithelial cycling in kidney repair. Curr Opin Nephrol Hypertens
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39.Montesano R, Matsumoto K, Nakamura T, et al. Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor. Cell
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40.Ishibe S, Haydu JE, Togawa A, et al. Cell confluence regulates hepatocyte growth factor-stimulated cell morphogenesis in a beta-catenin-dependent manner. Mol Cell Biol
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41.Karihaloo A, O'Rourke DA, Nickel C, et al. Differential MAPK pathways utilized for HGF- and EGF-dependent renal epithelial morphogenesis. J Biol Chem
2001; 276: 9166.
42.Tilghman RW, Slack-Davis JK, Sergina N, et al. Focal adhesion kinase is required for the spatial organization of the leading edge in migrating cells. J Cell Sci
2005; 118(pt 12): 2613.
43.Zhuang S, Yan Y, Han J, et al. p38 kinase-mediated transactivation of the epidermal growth factor receptor is required for dedifferentiation of renal epithelial cells after oxidant injury. J Biol Chem
2005; 280: 21036.
44.O'Brien LE, Tang K, Kats ES, et al. ERK and MMPs sequentially regulate distinct stages of epithelial tubule development. Dev Cell
2004; 7: 21.
45.Hellman NE, Spector J, Robinson J, et al. Matrix metalloproteinase 13 (MMP13) and tissue inhibitor of matrix metalloproteinase 1 (TIMP1), regulated by the MAPK pathway, are both necessary for Madin-Darby canine kidney tubulogenesis. J Biol Chem
2008; 283: 4272.
46.Sarwal MM, Vidhun JR, Alexander SR, et al. Continued superior outcomes with modification and lengthened follow-up of a steroid-avoidance pilot with extended daclizumab induction in pediatric renal transplantation. Transplantation
2003; 76: 1331.
47.Li L, Chang A, Naesens M, et al. Steroid-free immunosuppression since 1999: 129 pediatric renal transplants with sustained graft and patient benefits. Am J Transplant
2009; 9: 1362.
48.Racusen LC, Halloran PF, Solez K. Banff 2003 meeting report: New diagnostic insights and standards. Am J Transplant
2004; 4: 1562.
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1999; 55: 713.
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2008; 8: 753.
51.Isoniemi H, Taskinen E, Hayry P. Histological chronic allograft damage index accurately predicts chronic renal allograft rejection. Transplantation
1994; 58: 1195.
52.Nagarajan S, Shah S, Troxell M, et al. A novel drug toxicity pathology score in protocol biopsies can predict clinical graft and patient outcomes in pediatric renal transplantation. Boston, MA, American Transplant Congress 2004.
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2010; 89: 537.

domain: literature


text:
Secrets to Staying Healthy & Happy
Invigorating grassy tones were designed for fun in the sun!
An Ottawa teen received a double-lung transplant Friday after being diagnosed with a degenerative lung disease last July. Twenty-year-old Hélène Campbell used Twitter (#BeAnOrganDonor) to raise awareness about the importance of organ donation and even caught the attention of U.S. talk show host Ellen DeGeneres. According to a recent report by the Canadian Institute for […]
One in every three Americans is obese — and one in four Canadians. American doctor David A. Kessler shares his perspective on the lifestyle differences between our two countries and what Canada can do to halt the spread of obesity.
It’s never too late to learn something new! Here’s how learning to swim gave Nancy Angus a new outlook on life
We Also Think You’ll Like:
- Why This Woman is Committed to Cycling 200km Every June
- Sip Away Stress with this Soothing Turmeric Latte
- Meghan Markle Could Break This Tradition During Her Wedding to Prince Harry
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- Serve Up This Mediterranean Edamame Salad For a Protein-Packed Meal


text:
Original "Luna" (cat from sailor moon) painting done by artist Austin Parry. Done with metallic acrylic paints on 8.5x11in poster board. Metallic paint shimmers in the light. Comes already framed in black frame shown in picture. Original artwork comes without watermark shown. Original artwork is signed and dated on the back. Please allow 5-10 buisness days to ship. Ships within U.S. only. Refunds and returns are not accepted.
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domain: artistic


BEASTO BLANCO RELEASES SECOND VIDEO FROM THEIR UPCOMING SELF-TITLED RECORD SLATED FOR RELEASE ON NOVEMBER 25th VIA RAT PAK RECORDS
Video For The Song “Grind” Can Be Seen Here:
Now Available For Pre-Order At http://smarturl.it/
More Worldwide Tour Dates Added
(November 11, 2016 – New York, NY) Beasto Blanco, the band fronted by long time Alice Cooper bassist Chuck Garric, have released another video from their upcoming self-titled, sophomore release.
“Grind” is an adrenaline-fueled rocker that is the mantra for Beasto Blanco and the video can be seen here: https://youtu.be/HirAZpji-S4.
“‘Grind' is SO authentic to the character of Beasto and the Beasto Blanco lifestyle. The credo of working hard no matter what you were born into or what cards life deals you. Rise and GRIND no matter what and be the KING or QUEEN of your world,” explains vocalist Chuck Garric
Beasto Blanco is the follow up to the bands critically acclaimed 2013 release Live Fast, Die Loud and is available on November 25, 2016 via Rat Pak Records. Influenced by bands such as White Zombie and Motörhead, Beasto Blanco’s all new 12-song, sophomore release is a potent mix of heavy riffs, driving bass and melodic choruses. The album is currently available for pre-order via Rat Pak Records website at: http://smarturl.it/
BeastoBlanco16. It is also available at all digital retailers including iTunes (http://smarturl.it/ BeastoBlancoiTunes), Amazon (http://smarturl.it/BB16Amazon ) and Google Play (https://play.google.com/ store/music/album/Beasto_ Blanco_Beasto_Blanco?id= Bdm5cwr5hebufslvuyppibuvj4i).
The band also released the debut single “Feed My Frankenstein,” a cover of the Alice Cooper classic that features Cooper’s daughter on vocals. The video was released last month and can be seen here: https://youtu.be/XMLRw8OaUmE. The single can be heard on the “Nights With Alice Cooper” radio show, which is syndicated on over 100 stations worldwide. The song can also be heard at 15,000 AMC, Regal, Cinemark and NCM movie theaters in the United States throughout the month of November.
Beasto Blanco will embark on a 2016/17 Fall/Winter tour starting in November, that includes a string of U.S headline dates, as well as a recently announced arena tour of Europe with BÖHSE ONKELZ. They return home to the U.S for another run of headline dates that will conclude with performances on the 2017 Monsters of Rock Cruise in February.


CHARLESTON, S.C., Feb. 3.--Last week a gentleman about 70 years old and calling himself Dr. Mitchell, of Washington, D.C., arrived in Spartanburg, this State, and inquired the way to the Gowensville neighborhood, in that county. View Full Article in Timesmachine »
Full text is unavailable for this digitized archive article. Subscribers may view the full text of this article in its original form through TimesMachine.


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Everyone is welcome to participate!
Starting this Saturday, 5/22 and continuing through Saturday 5/29, FOM is asking Murphy students to go for walks and show their school spirit!
How to Walkabout
- Stop by the school to pick up a bag of fun supplies (if you did not already receive one).
- Color and post these pages in your street-facing window, or draw your own Murphy sign to put up. Use markers to color! (included in bag)
- Use the chalk (included in bag) to chalk the walk! Write encouraging messages or draw a picture to cheer yourself and Murphy on – DRAW BIG!
- Go outside and take a walk. As many as you want. They can be long or short! Wear a past walkathon shirt or any other Murphy spirit-wear if you might have to represent your school while you walk.
- Take pictures/selfies/short video clips/screenshots from your walk (or draw a picture about it if that feels more appropriate) and send them to email@example.com
- Share on social media with #MurphyWalkabout and #GoOutAndWalkabout if you’d like!
- To participate and enter to win raffle prizes, send your pictures to firstname.lastname@example.org
- Each day we get a pic from you will count as a new raffle entry!
- Entries will be chosen randomly so YOU have a chance to win!
- Check out the list of prizes here, with the grand prize being your very own Fit Bit!
- Take a picture of your chalk art and email it to us with your NAME and ROOM #.
- The top 3 entries will be posted on friendsofmurphy.org where voting will take place between June 4 – June 10. Anyone can vote!
- Art Contest prize is a free pass for you + up to 6 friends/family to visit the Museum of Contemporary Art, a gift card to Blick Art Supply, and more!
Raffle Prize Winners & Art Contest Winner will be announced Friday 6/11.
Good luck and have fun!


First it was reel to reel, to 8 track right? Then the cassette to the CD. The turntable has been the most essential instrument for Djs since Hip Hop’s birth. The record, the tone arm and the needle…. but how bout mixing and stratching without a needle?! Enters “PHASE“… its a electronic devise that sends the signal from the record to the computer….Please watch the video and wait for it….


Vevo is the world's leading music video network, connecting an ever-growing global audience to high quality music video Vevo is best known for providing music videos to YouTube. The service is also available as an app on selected smart TVs, digital video recorders, digital media players and streaming television services.
How Vevo and Revelator work together
- Revelator Pro
- Revelator API
Other Similar Integrations
and manage your catalog today


The highly-anticipated Mass Effect 3 demo is scheduled to launch on Valentine’s Day (and may cause a few emotional break-ups, depending on how much content is included). But if you can’t wait that long, then maybe you should check out this YouTube video. A lucky Xbox 360 player somehow gained early access to the demo, and recorded his playthrough of the single-player campaign for all to see. Of course, this is a total spoiler… so if you’re not into the whole ruining your gaming experience thing, then, whatever you do, don’t read on.
Oh… so you are interested? OK then. Here are the videos, generously made available by YouTube user ‘NinjaDancer’:


text:
You are Here: Home > FinXTech
With industries converging, partnerships take on a whole new meaning. Know what questions to ask and how to prepare for digital change.
MVB Financial Corp. is gaining deposits and more by banking fintech firms like BillGO.
Seacoast National Bank expects to be a top-100 SBA lender by the end of 2018.
U.S. Bank teamed up with the fintech company SpringFour to connect distressed borrowers with agencies and organizations that can help.
Most banks still manage their construction loans on cumbersome spreadsheets, but that wasn’t acceptable to a high-growth bank like Pinnacle.
Autobooks is helping ChoiceOne make life easier for small businesses, resulting in a loyalty boost for the bank.
The new technology ushered in a new experience for customers, and a cultural shift for the bank.
USAA and Clinc have partnered to build a smarter digital assistant.
Startup Innovation award winner puts Radius Bank in driver’s seat of souped-up decision engine.
A small bank and its closely tied fintech are offering a single marketplace of APIs to make firms across multiple industries more efficient.
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domain: finance


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Lecture on perception
Finkelstein, Louis, 1923-2000
1971 September 29
Place of publication, production, or execution:
No place, unknown, or undetermined
1 sound tape reel : analog ; 7 in. ; 1 hr., 28 min., 42 sec.
Lecture given at Yale University.
Lecture on perception, 1971 September 29. Louis Finkelstein papers, [ca. 1944-2000]. Archives of American Art, Smithsonian Institution.
This item has been digitally reformatted. It is available by requesting an appointment in the Archives of American Art's reading rooms, or in certain situations as a Reproduction Request.
Current copyright status is undetermined
Archives of American Art, Smithsonian Institution Washington, D.C. 20560
Art and science
See more items in:
Louis Finkelstein papers, [ca. 1944-2000]
Archives of American Art

domain: library


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Hungry Harry's Climb
Hungry Harry's Climb is a fun retro pixel platform adventure of poor Harry! He was taking a nap when the ice broke from under him! Harry is too hungry and he need to grab some food. Help him climb out of the caves, and make sure he gets enough mushrooms to eat before he starves! Enjoy playing Hungry Harry's Climb adventure game here at Y8.com!
The greedy cat pharaoh Pawhamon steals the crystal containing the power of a dark cat deity, cursing his kingdom in the process. Nyahotep (the aforementioned dark deity) sets out to reclaim the crystal, plus interest.
Run Imposter Run
Run Imposter Run - Welcome to interesting Impostor adventure game, beware of flying creatures they are very dangerous and try to collect all coins on the platforms. Complete 20 different levels and every difficulty level of hazards and different. Start your Impostor adventure right now.
A Lone Wizard
A puzzle/metroidvnia/platformer about a wizard that has to cooperate with himself to win the game.
Barvest: The Iconic Bug Harvest of 2005
Barvest: The Iconic Bug Harvest of 2005 is a super adventure game with a spider and an unknown world. You play as a ravenous spider on a mission to gather as many insects as possible in this 3D platformer game. You have to collect points, and flies on platforms. Play this journey game at Y8 and have fun.
Astronaut Us - Cool adventure game with many various levels, you need to survive and find the white star. Control the red astronaut and use the rope to avoid traps and move to another platform. Hold the jump to make a long jump and be careful, don't fall down while jumping.
Tiny dungeons an adventurous game with unexpected traps and obstacles. Our cute little among us guy has trapped in the little dungeons which have a lot of traps and obstacles where he has to get rid of all of them to escape from the dangerous dungeons. Help him by moving him strategically and calculate the trap's intensity and escape without getting killed. If you go killed do not worry, it will start again, and use the previous dead hero as the step to climb on,. So plan your strategy and complete all levels. Play a lot more adventure games only on y8.com
A 2D puzzle game where you can manipulate time! Use Rewind ability to go back in time!
Santa Claus Rushed!
You play with Santa who is late to deliver his presents. Race against time and deliver all the presents before Christmas is over! Carry the gift to the point of delivery. Deliver the gift before time runs out.
Panda Love is an adventure platformer with more than 20 levels in which you need to guide the panda back to his girl. Tap with your finger or jump with the mouse to grab all yellow blocks and open the gates for the next levels.
Zoomies is a short simulation game where you play as a Cat on a mission to create chaos in your owner’s absence. Choose from room, house or apartment. Then play as a cat and collect all the needed items before time runs out. You can unlock new cats by toppling their frames to the ground. Enjoy playing this game here at Y8.com!
Mini Tooth is a platform game with the mini tooth as hero who has a unique ability to teleport, allowing him to traverse the game world effortlessly with incredible speed and flexibility. The teleport ability grants the player the power to instantly move from one location to another, bypassing obstacles, enemies, and other dangers in their path. Collect the keys and open the gate complete each level. Enjoy playing this game here at Y8.com!
Jump in the Line
Jump in the Line is a 3D adventure game in which only one block is alive. You need to roll on platforms and jump over obstacles to overcome them. Explore these endless locations and jump on other blocks to keep rolling. Play now at Y8 and have fun.
Ride your slime, avoiding the spikes and reach for the door for the next level. Very simple, but, there is always one, but, you need to be careful with the platforms. It will be necessary to remove some platforms. To remove the platforms, you need to turn off the color switch on the platform you want to remove. Just click again on the switch to return the platform on its place. Enjoy this puzzle platform here at Y8.com!
Platformation is a hardcore platformer game with slime and spike challenges. You can use platforms or make new ones to overcome obstacles. Control the magic slime and try to complete all the game levels. Play this platformer game now at Y8 and have fun.
Kogama: Lava Tube
Kogama: Lava Tube is a fun racing game in a lava tunnel. You need to collect enough energy for your car and reach the flag with precise movement for 40 seconds. Drive the car on platforms and jump over obstacles. Play the Kogama: Lava Tube game at Y8 now and have fun.
Jump Changer is a free physics game. Leap into action and brace for impact as you dash from one colorful platform to the next. In Jump Changer, you're a cube suspended in mid-air, with a path of colorful platforms below you. Your mission is to click or tap the correct colored square on the bottom of the screen to make your cube leap to the correspondingly colored platform. But beware, dear gamer-friends, and hesitation is your most formidable foe. If you pause to ponder, the platform beneath you will vanish into thin air, and your quest shall come to a swift and unforgiving end. Are you prepared to leap into action? Enjoy playing this game here at Y8.com!
Particle Pandemonium is a puzzle-platformer game where you use knowledge of chemistry by controlling a proton and their electron sidekick as they travel through element-themed levels. Switch between proton and electron when the skill is unlocked and help each other overcome various obstacles to pass the level. Enjoy playing this amazing platform game here at Y8.com!
Delia The Traveling Witch
Delia The Traveling Witch is a action platformer about a traveling Witch and her pet Pig named Bao. Delia and her Glowing Pig Bao are now in Glutinous Kingdom. After receiving a request to cure a sick child, they are wrapped in an adventure that spans the whole magical land! Can you help Delia overcome all the challenges ahead? Enjoy playing this adventure game here at Y8.com!
Ninja Spike Avoider
Ninja Spike Avoider is a simple platform adventure game and your goal is to help the ninja to jump and double jump on platforms to avoid deadly spikes while collecting as many coins as possible. Reach the exit to pass the level. Enjoy playing this game here at Y8.com!
Kogama: Football Adventure
Kogama: Football Adventure is a crazy 3D game where you need to roll the ball and overcome all the challenges. Collect fuel for the ball and jump over lava obstacles. Play this 3D multiplayer game with online players and become a champion. Have fun.
Slope is the ultimate running game that will put your skills to the test. Speed down on a randomized slope. The farther you go, the faster your ball travels. This game might look simple but playing this will give you extreme adrenaline rush. Just remember to avoid obstacles and those red blocks. Always be on track to get a high score and you might have your name on the leaderboard!
In Superfighters you control a little man and it is up to you to learn all the controls in this wonderful arcade fighting game. Pickup weapons, grenade launchers, and team up with friend locally in two player mode! Yes, you can even punch. Choose the arena and the number of CPU controlled players.
Parkour Block 3D
Parkour Block 3D is a fun skill game, classic mode from your favorite games right in the browser on your computer and phone! Enjoy 35 unique levels with varied mechanics and real hardcore parkour jumping game experience. Have fun playing Parkour Block 3d game here at Y8.com!
Sent on a mission to underground galleries, you will have to explore them while fighting sticky monsters. These creatures could wipe you out if you come into contact with them. You will therefore have to stay away from them at all costs and shoot them to eradicate them all. Jump from one platform to another, fire on your enemies, and much more. The dialogues will mark save points. Good luck !
Mermaid My Valentine Crush
Mermaid My Valentine Crush - Arcade 2D game with simple controls and love story. Play this interesting platformer puzzle game. with 30 levels. You need to help the mermaid couple to celebrate valentine's. Jump over traps and obstacles to keep running and help the mermaid. Play now at Y8 and have fun.
Kogama: Parkour 60 Levels
Kogama: Parkour 60 Levels is a fun 3D parkour game with new platforms and obstacles in 60 different stages. Play the Kogama: Parkour 60 Levels game now and start your own parkour adventure to compete with other online players. Have fun.
Down the Hill
Down the Hill is an exhilarating endless runner game where players guide a character downhill through challenging terrain. Avoid traps as you move as quick as possible. With dynamic landscapes and quick reflexes, players experience a thrilling downhill adventure. Enjoy playing this game here at Y8.com!


text:
New Ukip leader Henry Bolton kicked off his stint by attacking multiculturalism and immigration. Last week the former cop and soldier was elected Ukip’s fourth leader in just over a year.
Bolton took nearly 30 percent of the vote while Anne Marie Waters, a vicious Islamophobe, came second with 21.3 percent.
In his first speech as Ukip leader Bolton declared, “Multiculturalism is swamping or displacing our own British culture.” He added that immigration is “overwhelming” public services.
At a press conference Bolton said LGBT+ rights had gone “too far”. He said he rejected the idea that “we are at war with Islam”. Yet during his election campaign he said he was proud of “fighting Islam”.
Some 18 of Ukip’s 20 MEPs had threatened to resign had Waters won. And former leader Nigel Farage had floated the idea of setting up a new party.
The election of Bolton staves off an immediate split in the party. But it hasn’t lessened its vile racism.

domain: sociology


text:
Eat Green, Be Healthy
Potato and Chickpea Salad RecipeMakes: 6 servings
1 1/2 pounds baby or new potatoes
1/2 cup dry white wine
1 tablespoon olive oil
3 tablespoons whole-grain mustard
1 teaspoon salt
1 tablespoon fresh thyme, minced
15-ounce can chickpeas, rinsed and drained
2 scallions, minced
1 small red pepper, diced
Cut potatoes into quarters and cook in salted, boiling water until softened. Drain and set aside. In a small bowl, whisk together wine, olive oil, mustard, salt, and thyme. Transfer cooked potatoes to a large bowl. Add chickpeas and pour dressing over the top. Toss to coat. Stir in scallions and red pepper.
Nutrition facts per serving: 190 calories, 5g protein, 31g carbohydrate, 4g fat (<1g saturated), 5g fiber.
What do you think of this story? Leave a Comment.

domain: food


The Cornerstore Cooperative, a new store in Bellport, Long Island, was born when three stylish and civic-minded locals — Johnny Knapp, Tyler Healy and Quinn Sherman — tricked out the empty, forlorn windows of a recently vacated storefront at a prime corner in town. What started as blight-busting quickly stirred up interest and led to requests for an actual boutique to match the clever displays they had conceived. Read more…
Aspiring male models in New York City may want to consider relocating to Long Island’s South Shore. The faces for the Matthew Brookes photo essay, “Locals Only,” in the Style pages of this Sunday’s New York Times Magazine, were found in Long Island’s Suffolk County. It all started when the magazine’s men’s fashion director, Bruce Pask, saw the beachy, West Coast themes of the Spring fashion shows. He immediately thought of the young locals who live near his summer home. Pask tapped Tyler Healy, an art student and photographer, to scout potential subjects — in other words, rope in friends and family to be models. Below, the photogenic yokels.
(clockwise from left)
NAME: CONNOR BROGAN
WEIGHT: 175 lbs.
OCCUPATION: “I work for my family business building luxury sport fishing boats. I’m a rigger: an electrical acquatic engineer.”
MODELING EXPERIENCE: “I’m a model citizen.”
PERSONAL STYLE: “Hipster-type.”
DID YOU LIKE YOUR CLOTHES? “A lot. I tried to steal them. Can you get me that Versace jacket I had on?” Read more…


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A few days ago, Troye Sivan revealed that his new album, Wild, will be released before the end of 2015. And he made that announcement, of course, via YouTube at VidCon -- essentially the Comic-Con of vloggers and web video personalities.
It's a fitting way to drop the news since Sivan, whose last EP shot up to number two on the Billboard 200 chart last year, has built up a fan base almost exclusively through his YouTube channel since 2007. That kind of success arc used to be a novelty, a quirky trend reported on by The New York Times. But now, it's a reality.
And because YouTube has been around for over a decade now, we have a plethora of examples to prove it. Here are our favorite YouTubers who leapt from our computer screens into the throes of real success.
Adore Delano began in earnest, belting out Jason Derulo covers in what was probably a bathroom. But those impressive pipes led to appearances on "American Idol" and "RuPaul's Drag Race" -- and a debut album, Till Death Do Us Party, hitting 59 on the Billboard 200 in 2014.
Before the "Dirty Work" singer was breaking hearts on VEVO and charting on the Hot 100, he was singing happy birthday to girls at their quinceañeras and goofing around with his vlogging pals just five years ago. They grow up so fast.
Once known on YouTube as zeldaxlove64, Christina Grimmie is now known for her show-stopping performances on "The Voice," where she landed a record deal that helped her 2013 album, With Love, crack 101 on the Billboard 200.
While not a pavement-hitting YouTuber -- he also had performed with California's 42nd Street Moon since the late 1990s -- Darren Criss did indeed post a few acoustic covers from his bedroom long before landing on "Glee" or, most recently, in "Hedwig And The Angry Inch."
Five years ago, Greyson Chance took Lady Gaga's "Paparazzi" to new heights with this bellowing piano cover (he was in sixth grade, FYI). Shortly after, his major-label debut, Hold On 'Til The Night, debuted at 29. Because, like, LISTEN.
It all started with a simple take on Chris Brown's "Look At Me Now," which racked up tens of millions of views for its inventive style and high production quality. Karmin parlayed that success into a slot on "SNL" and two singles that climbed to No. 1 on the U.S. dance charts.
Whether or not it's actually a "bad" song is irrelevant. "Friday" took Rebecca Black to No. 1 on the Billboard Heatseekers Songs (and 53 on the regular 100). So take THAT, haters!
Straight No Chaser
In one of the weirder tales of the digital age, a member of a cappella group Straight No Chaser uploaded this video in 2006 (though it was filmed in 1998), and it promptly blew up. Instead of fizzling out after a few weeks, though, Atlantic Records signed the group to a five-album deal -- and the first four released have all charted.
In addition to being the most 2007 thing ever, Soulja Boy's "Crank That" took the pop world by storm -- a cyclone that kept the song at No. 1 for a staggering seven consecutive weeks, you guys. And it all started, as things tend to do, with this goofy, quirky, low-quality YouTube vid.
Tori Kelly's golden teenage pipes carried her from the web to "American Idol" tryouts and, in 2013, to Capitol Records. Her debut, Unbreakable Smile, debuted at No. 2 on the Billboard 200 in June. You go, Tori.
WE. WILL. NEVER. EVER. FORGET.


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Financial recovery isn’t the only game in town; the emotions of future asset owners will require a rebuild too
By Henry Adefope, Associate Partner
A fund manager friend, who has never seen such unpredictability in the markets, says he is focusing on his on convictions as he can’t control how financial market participants, business leaders or consumers, will behave.
We have no idea either.
Many headlines are rightly focusing on the eventual recovery, and what will determine whether this recovery is ‘u’, ‘v’ or ‘s’ shaped. A feature that has often been missed out is the impact on the economy has more to do with human psychology than immunology, absent a vaccine or a very effective cure, and certain economic dynamics.
Unprecedented change is imminent. As unsettling as that sounds, it’s a peculiar dynamic that may just change how those between their teens and thirties view risk.
Emotion-led recoveries require an understanding of group behaviour, so audience insight and behaviour-led data will be crucial for mitigating business disruption. Applying understanding will be the second step; the tone adopted will be important, therefore understanding exactly how and when they communicate to them post Covid-19... should pay dividends.
We know that events which threaten populations have a lasting impact on attitudes to risk too. In the 2013 paper by Yi Kim - The Long-Run Impact of Traumatic Experience on Risk Aversion - she examined the long-run impact of exposure to a traumatic event in early childhood on risk attitudes by studying the Korean War. Her team found that those who spent their early childhood during the peak of the war remain more risk averse five decades later, even after controlling for age.
Generational transfer has been a prevalent theme within the investment world for good reason; some have cited as much $68 trillion moving between generations within 25 years. There is a lot to play for, for those who understand the emotional drivers of the incoming generation of asset owners.
Risk is going to mean something completely different to the Gen-X’s, Ys and Z’s, to whom medical facemasks, social distancing and proactive hygiene will now be commonplace. Audience insight must rightly become the priority; those focused on this will make the recovery a more positive and collaborative one for their stakeholders.


From multinational battery developers to commercial-vehicle components manufacturers merging new-age motors with established power-transfer technologies, Battery & Electrification Technology's Fast 40 presents some of the most important names in electrification. Entities from the automotive, commercial-vehicle, and aerospace sectors are represented, as their work developing electrification strategies for their respective industries touches economies on nearly every continent – and their parallel engineering paths converge to accelerate transportation's transition to electrification.
Established in 2007 as a joint venture between Nissan Motor Co., NEC Corp., and NEC Tokin Corp, AESC (Automotive Energy Supply Corporation) develops and produces high-performance lithium-ion batteries for light vehicles. To date, its batteries manufactured in Japan, the U.S., and Europe have all been installed in over 600,000 EVs with a zero rate of critical malfunction.
Airbus developed the first all-electric, four-engine aerobatic aircraft in 2010. Since then, the company has developed several successful electric/hybrid aircraft, including the E-Fan 1.1, a 60 kW all-electric aircraft that flew across the English Channel in 2015.
Founded in 2019 by five former Airbus Vahana team members, Airflow's M200 aircraft, scheduled to make its debut in 2025, will be able to carry 2,000 pounds of cargo, nine passengers, and be 100-percent carbon neutral. It will require just 400 feet of takeoff and landing distance and have a reputed 500-mile range.
Recently acquired by BorgWarner, German brand Akasol supplies a third-generation battery system for commercial vehicles that reportedly has the highest energy density available on the market. A service life of up to 4,000 charging cycles also is achieved.
Allison's eGen Power series of fully integrated electric axles is designed to fit between the wheels of medium- and heavy-duty trucks and buses, replacing the vehicle's traditional powertrain. It also integrates a two-speed gearbox in the central housing, enabling the high starting gradeability and increased top speed and efficiency.
American Battery Solutions produces custom and off-the-shelf battery packs for buses and medium- and heavy-duty trucks. These battery systems include integrated liquid cooling and battery-management systems with ASIL-C functional safety.
With decades of experience designing integrated flight controls and propulsion systems, BAE Systems now is investing heavily in flight and safety critical systems to enable the future of hybrid and all-electric aircraft. Three primary focus areas are energy-management systems, integrated control systems, and power conversion systems.
One of the oldest names in automotive power transmission, BorgWarner offers a full line of EV, hybrid, and ICE products including battery systems, EV transmissions, electric machines and drive modules, e-axles, power electronics, battery charging and thermal management solutions.
From e-bikes to electric heavy trucks and railcars, Bosch has systems solutions for every electrified vehicle including battery-electric drive systems, e-axles, fuel-cell electric drives, hybrid-electric technologies including 48-V solutions, and thermal management.
BrightVolt develops solid-state lithium battery chemistry and has sold over 15 million primary/nonrechargeable solid-state batteries worldwide. The company's new “platform” solid-state polymer electrolyte is aimed at secondary/rechargeable Li-ion batteries used in consumer electronics and e-mobility applications. The company's proprietary technology is polymer matrix electrolyte (PME).
BYD currently is ranked as the world's 4th largest battery manufacturer, specializing in safe LFP (lithium-iron phosphate) cell chemistry, as well as electric motor design and engineering. Based in China, BYD has North American headquarters in Los Angeles, CA, and a 550,000-ft2 electric-bus manufacturing facility in Lancaster, CA.
For the past five years, China-based CATL has been ranked as the world's largest EV battery supplier and a major developer of lithium-based cell chemistries. CATL has among its OEM customers Tesla, NIO, and Volkswagen and Fisker's upcoming Ocean SUV. Additionally, CATL has developed other battery technologies such as sodium-ion cells as well as its own recently announced EV battery-swap brand.
High-voltage current sensing for 400-800-V EVs, battery impact detection systems, and intelligent battery sensing for the vehicle's conventional 12-V battery – essential for micro-hybrid stop-start operation – are technologies engineered for electrified vehicles by Continental Automotive.
Cummins’ New Power business works with multiple OEMs to integrate its battery packs and modules for application in trucks, buses, and off-highway machines. Cummins also released its new PowerDrive 8000 system for terminal tractors, which will be powered with up to 182 kWh of fast-charging Cummins batteries and equipped with DC-fast charge technology.
Global Tier 1 supplier of e-mobility products for light, commercial and off-highway vehicles, including in-house expertise in gearboxes, low- to high-voltage motors, inverters, controls, and thermal and battery management.
Denso's decades of experience as an automotive electronics leader is being harnessed for electrified vehicles. The company is a volume producer of electric-powertrain system control and lithium-battery control systems, battery monitoring and battery current sensors, DC-DC converters, electric machines and drive modules, thermal management, and hydrogen control technologies for fuel-cell vehicles.
Eaton formed a new ePowertrain business unit to focus on products from its electrified-vehicle (EV) transmission, reduction gearing, and differential portfolios for commercial and light-duty EVs. Its portfolio of multispeed transmissions includes 2-, 4- and 6-speed electrified commercial-vehicle transmissions based on architecture typical of automated manual transmissions and with shifting synchronized without a clutch.
EVE is a leader in developing and manufacturing lithium battery cell chemistries, including lithium thionyl chloride (Li/SOCl2) and lithium manganese dioxide (Li/MnO2), as well as developing lithium rechargeable cells and customized portable power source solutions.
One of the world's top engineering consultancies, FEV serves its OEM partners by developing technical solutions and work on new standards for innovative energy storage systems, focusing on battery energy density, safety, packaging, production strategies, and testing.
GaN Systems aims to obsolete silicon as the mainstay of computer chips with gallium nitride (GaN), a hard and mechanically stable wide-bandgap semiconductor that offers higher breakdown strength, faster switching speed, higher thermal conductivity, and lower on-resistance. These attributes lead to EV power systems that are smaller, lighter, less expensive and have up to 25 percent less power loss.
Swedish-based Heart Aerospace is in the process of developing a 19-passenger electric aircraft called the Heart ES-19 that can travel 250 miles and has a backup generator for energy reserve and range extension. United Airlines and commercial aviation holding company Mesa Air Group have already placed orders for approximately 200 electric aircraft, the first of which should be ready for delivery in 2026.
Hyliion produces electrified powertrain systems that can augment or fully replace diesel- or natural gas-fueled commercial-vehicle powertrains. Its Hybrid eX solution designed for Class 8 trucks bolts onto existing or new OEM truck chassis.
Global researcher, developer, and builder of lithium-ion batteries for automotive EV, IT, and ESS applications. Worldwide production sites and supplier to several major automakers.
The Loveland, CO-based company claims to be the first commercial EV manufacturer to offer electrification of both legacy OEM platforms and purpose-built vehicles. Its eChassis platform accommodates various battery sizes and configurations, as well as different powertrain integrations and wheelbases.
Multinational Tier I supplier of electrified powertrain components and systems for passenger and commercial vehicles. eDrive portfolio includes components for EV, HEV, and PHEV applications.
Develops and manufactures energy storage and power-delivery solutions. Focus on ultracapacitor applications for consumer and industrial electronics, renewable energy, automotive, transportation and information technology.
Meritor, which recently entered into an agreement to be acquired by Cummins, has begun production of its 14Xe ePowertrain, a fully integrated, all-electric drive system for Class 8 trucks. The modular design enables the interchangeability of key components, including electric motors, transmissions, gearing, and brakes.
Sweden-based battery cell manufacturer Northvolt offers high-performance “green” lithium-ion cells based on proprietary Lingonberry NMC chemistry. Available in cylindrical and prismatic formats, the cells reportedly offer a minimum 1000+ charging cycles, are 95 percent recyclable and will utilize 50 percent recycled raw materials by 2030.
Developer of advanced EV Battery & Electrification Technology. Focus on hybrid battery-chemistry applications that incorporate lithium-ion phosphate chemistry.
Designs, engineers, and manufactures lithium-ion battery systems for EV, HEV, and PHEV applications. Worldwide production facilities supply major automotive OEMs.
Researcher and developer of anode-less lithium-metal solid-state batteries for EVs. More than 10 years of R&D efforts and 200 patents and patent applications.
Rolls-Royce currently envisions four key markets where hybrid-electric technology will play a key role: small propeller aircraft, urban air mobility, commuter aircraft, and regional aircraft. Among current projects is the Magnus eFusion, a two-seat training aircraft that serves as a flying testbed for the sub-100 kW propulsion systems developed by Rolls-Royce Hungary.
Developer of prismatic-format lithium-ion batteries for EVs, PHEVs, and HEVs. Also manufactures low-voltage system that combines super-capacitor technology with conventional battery storage.
Global Tier I developer and supplier of electrified-vehicle driveline components. Portfolio includes traction motors, electric-drive modules, and wheel-hub motors.
Global research, engineering and manufacture of electric drive systems for consumer and commercial vehicles. Manufacturer of consumer EV chargers.
Developer and producer of lithium-ion battery systems for EVs PHEVs and HEVs. Global footprint of manufacturing facilities supplies variety of automotive OEMs.
Developer of patent-pending LiSTR direct lithium extraction process claimed to drastically reduce the recovery time of extracting lithium from brine. Flagship development site located in the southern U.S.
Research and development of nanosilicon EV battery anode as well as solid-state Battery & Electrification Technology. Development focus is to speed recharging times and enhance safety.
Wright Electric, a New York-based company funded by NASA, the U.S. Department of Energy, and the U.S. Air Force among others, specializes in developing technology for large commercial airplanes. The company is designing the all-electric Wright Spirit, a 100-passenger airplane designed for one-hour flights.
Multinational Tier I supplier of EV drive-system components and electrical-system software for consumer and commercial vehicles, as well as other modes of mobility. Passenger-vehicle portfolio includes modular electrified axles and all-wheel-drive solutions.


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Treport 2 Drawer Nightstand By One Allium Way by One Allium Way #1
- Color: Antique White
- Frame Material: Solid + Manufactured Wood
- Assembly Required: No
- Number of Drawers: 2
- Overall: 28 H x 28 W x 17 D
Rugs give cowl to your floors and comfort to your feet. They can be used to complement, contrast or cheer up your d?cor, and will help to zone, tie along, or divide rooms. In this wayfair rugs buying guide we help you opt what will work best in your house. Therefore, if you would like help differentiating between what is available, what each can bring to your space, and where to lay it, simply walk this manner...
At wayfair we tend to favour natural fibres, and our biggest, heaviest creations are wool rugs, that are created in wool pile on a cotton backing. Continuously with an eye fixed on the craft component, we tend to categorise our rugs consistent with the technique with which they're made.
The pile of those rugs is formed by tufts of thread being pushed through a pre-formed cotton backing. These are then mounted into place with a further backing of latex.
Durability is the watchword of the hand-tufted rug and each is incredibly exhausting carrying over time. Statement designs are typically realised in hand-tufted Andice Platform Bed by Latitude Run rugs. For instance, bold, geometric drawings translate well on them, as do detailed, little-scale patterns.
The pile of Stewartville Upholstered Bench by Corrigan Studio these rugs is created from individual threads being hand twisted around the warp.
Highly sturdy and stunning rugs, these are sometimes textured, dense and luxuriously soft underfoot. As the foremost labour-intensive of all varieties, hand knotted rugs tend to be real investment items.
These rugs will be shaped of a mix of materials, typically cotton, wool or a blend of both. They're created via a a lot of ancient loom-weaving technique.
Larger scale, regular patterns such as stripes or geometrics are a flat-woven rug's reason for being. Being lighter in weight, they can be taken faraway from our stores rather than delivered. They're additionally lighter on your pocket, creating them an straightforward, affordable update to make.
The newest addition Treport 2 Drawer Nightstand By One Allium Way by One Allium Way #1 to our rug vary is our handwoven pile rugs. They're woven, instead of tufted and lead to a thick, additional relaxed pile.
The hand-weaving method suggests that our rugs are longer-lasting and additional reasonable. The neat alignment of threads and a decent weave thread allows for a greater level of detail in the design, both in terms or pattern and colour.
There are lots of things to consider after you?re selecting which rug is best, from colour to how a lot of of the area you want to fill.The first question is where are you going to place it? Wool
Highly sturdy and the hardest wearing fabric for a rug, creating it excellent for heavy traffic areas.Cotton
Lightweight and straightforward to clean at an inexpensive worth, cotton rugs are nice for those that like to change up their interior. All our cotton rugs are woven or screen printed with wayfair exclusive styles. Recycled cotton is additionally a key trend for us (chindi cloth) in our rag-rug designs that are ideal for environmentally acutely aware customers. And what makes them even better, every one can be a very little completely different from the next.Viscose
Half of an up and returning fabric trend, Viscose is extraordinarily soft underfoot and includes a refined sheen end, creating it excellent for luxe interiors. Every design is often in bright, daring colours as the fibre can take on saturated colors and designs. However, this kind of rug isn?t a sensible choice for messy, clumsy homes.Jute
Jute is a great means to feature a minimal, rustic look to your home.Space kind
A rug for a playroom, as an example, will differ from one for a kitchen. Each need to be hard carrying, but in material and format they?ll contrast.
Hand-tufted rugs are nice for living rooms, because they?re heat and sturdy. Kitchens favour a flat woven rug for lacking pile and being easy to clean. This is often the rationale flat-woven also work for home offices ? wheeled chairs will easily move over their smoother surfaces.Size
Do you want to fill the floor or outline a zone inside it? For instance, a hallway can look smaller if the rug among it pushes right out to the skirting boards. Meanwhile, an open-plan living room/ dining room / playroom setup can be subtly subdivided with 3 completely different styles or textures of rug. These ought to tone in with or complement one another thus they don?t battle for attention.Design
The design of the Treport 2 Drawer Nightstand By One Allium Way by One Allium Way #1 rug you decide on is after all entirely up to you.
However as a general rule of thumb, it?s worth considering alternative pattern and colour within the area?s decor before you make your selection. If your footage or textiles are busy, a neutrally-patterned or block coloured rug will sit better among them. Hand knotted and flat-woven styles are each ideal for this.
For rooms that are minimalistic in look, or plainer and additional pared back in their design Brian Wingback Chair by Gracie Oaks details, texture, pattern and a mixed palette will add interest. Suppose hand-tufted or flat-woven in these cases.Colour Theme
Whether starting your area with a rug and letting its palette inform other accessories, or adding the rug to an existing scheme, keep in mind that a bold pattern or print can likely become a focal purpose, while textured and plain rugs will blend in superbly.Cleaning your rug
We forever recommend that our rugs are cleaned by a skilled carpet cleaner however check the individual care label because some flat-woven styles can be spot-cleaned. Sensible carpet cleaners will already apprehend the below points, but to arm you with some information, we tend to?re listing them during this buying guide.
Our Treport 2 Drawer Nightstand By One Allium Way by One Allium Way #1 rugs ought to be cleaned when flat, employing a water-based mostly shampoo.Bleach, optical brightening agents and biological powders are a no-no, as are harsh chemicals and pesticides. These will all cause fading and will damage the latex binding of the rug.We tend to caution against dry cleaning Beames Upholstered Panel Headboard by Canora Grey and tumble drying.Rugs must be dried completely once cleaning to avoid color transfer on to carpets.What you can do to take care of your rug
Often brush or vacuum to softly maintain its fibre lustre (within the case of hand-tufted and handwoven items).Carefully cut loose threads to remove them ? never pull.Store your rug flat where potential, or if rolled, with the backing on the surface. Don?t fold it.Dry, well-ventilated areas are the simplest spot for a stored rug. An airtight bag is not.Some shedding could occur, however this is normal. It can cut back over time and with regular vacuuming.Colour variation may occur between lined and exposed areas of flooring over time.Effects of sunlight
Some natural fibres will discolour slightly when exposed to natural light over long periods of time. If solely some elements of your rug are exposed to the sun throughout the day, regularly turning it will help to ensure it doesn?t become patchy. Where you have a rug, you will conjointly notice a difference in colour between lined and non-covered areas of flooring over time.

domain: design