Hose Bend Restrictor Rubber for 1/2" Coo Steam Hose Sku 8.705-482.0 Price: $12.99 - In stock Product ID: 4214 Customer Review Write Your Own Review Share your opinion Write a review You''re reviewing: Hose Bend Restrictor Rubber for 1/2" Coo
information is updated after hose asselies pass Dixon steam testing. Material: Carbon steel with zinc plating Select a Product Part Nuer Description Size CSTMS-150 male pipe thread x stem for 1½” ID hose 1-1/2" CSTF075-1330 3/4" 3/4" 1"
Also, proper installation, usage, and maintenance of the steam hose you select will contribute to increased operator safety. See the steam safety section for further information. WARNING : Consult with the coupling manufacturer to make sure you choose the …
Flexsteel 250 and Plicord 250 Steam Hose available for your varying steam appliions. Used for all-around service in chemical plants, refineries, and more For cleaning, heat control, fire prevention, pumping, thawing, blow-out service, steam pumps and hoists in
1.0 IN FDA STEAM HOSE FDA title 21, art.177.2600 for aqueous foods More Info IN STOCK UOM : FT shopping_cart Add to Cart STEAM-1.5-100N 1.5 IN TEX-STEAM  More Info IN STOCK UOM : FT shopping_cart Add to Cart Don''t see what you need?
These steam guns are easy and affordable to rebuild and repair. Handles are plated to be rust resistant with a heavy coating of zinc. Steam guns have Teflon packings and viton 0-rings to resist the heat and chemicals to secure a long life. Features: Inlet: 1/2
Steam Transfer Hose Construction Tube Pyrosyn® synthetic rubber Cover Red Pyrosyn, smooth finish, pin-pricked Reinforcement Braided steel wire (3/4" and 1" have 2 steel wire braids) Color RED Min. Temperature-40 ºF-40 ºC Max. Temperature 450 ºF I.D.
Steam Hose We take steam hoses seriously! Not properly asseled and maintained steam hoses can be potential safety hazards for plant personnel and also be a huge inefficiency if the hose is constantly leaking steam. A leaky steam hose can “Hiss Away” 2.6
1.5″ x 1.5″ Vacuum Hose Joiner Made from Durable PCVI, to Resist Cracks and Breaks. Used to Securely Connect two 1.5″ or 38mm Vacuum Hoses Together Rated 4.20 out of 5
V19499 Steam Hose 1-1/4 Inch (Burstproof) (Sold per Inch) Used for Braun Equipment $2.97 Steam Hose 1-1/4 Inch (Burstproof) (Sold per Inch) quantity Add to cart Add to quote RWM Part #: NP-040-T14010000 egory: Hose Related products Steam Hose
Comel A0028 1 x Meter steam hose, standard Comel iron requires two meters, Black rubber hose covered with braiding. Steam pipe, For comel iron 0115 9271155 Davrus Commerce My Account My Wishlist My Cart Checkout Log In Shopping Cart item - £0.00
9/1/2019· Congratulations on the purchase of your new Whirlpool Steam Dryer. Let''s take a look at how to connect the water hose to your dryer to make it steam. Here are some of the tools you''ll need: • 1
Steam Hose 1 3/4In Id Large (Per Foot) This item is sold by the foot. Enter the nuer of feet you want in the quantity box. 1 3/4 IN ID hose.
Integrated 1/8" NPT port for steam port recirculation or other gauge connections. Conveniently add a 1/8" NPT port into your top radiator hose. Due to the different display and different light, the picture may not reflect the actual color of the item.
STC1700200 - 1/2 Hose Barb x 3/4 x 1-1/2 Sanitary SIP Connector Request a printed copy of our alog. If you are distributor, please click here to order in bulk. Order alog
Page 56 Steam Hose Novaflex 5510 Black Low Pressure Conductive Steam Hose 100psi This textile reinforced steam hose is an excellent flexible light weight hose for transferring steam in medium temperature appliions. Construction: Tube: Black EPDM
Kuriyama T340 1 in. NPT 270 PSI EPDM Steam Hose Ground Joint Asselies w/ Male x Ends $123.70 - $297.60 Choose Options Kuriyama T340 3/4 in. 270 PSI EPDM Steam Hose Asselies w/ Male & Ground Joint Ends $107.70 - $246.10
Parflex metal hose asselies are leak-free, full vacuum hose solutions. Product Features • Excellent chemical resistance • Sizes 1/4” I.D. up to 12” I.D. • Proprietary Core Tube Manufacturing Process - Yields a uniform wall thickness, promoting even
Steam hose, 1/2 in. inside diameter, 1-1/16 in.es outside diameter, 1 braid, maximum 250 psi. Designed for cleaning, heat control, fire prevention, pumping, thawing, blow-out service, steam pumps and hoists.
Rubber hoses and hose asselies for steam -- Test methodsThis standard was last reviewed and confirmed in 2014. Therefore this version remains current Hoses , Metal Shower Hoses ,Braided Hoses , Flexible Hoses hoses, shower hoses, garden hoses
Whirlpool W10819173 Dryer Steam Hose Installation Kit Genuine Original Equipment Manufacturer (OEM) part Sold by DIY Repair Parts Bundle $3540.97 $1640.75 Kenmore Elite 41072 – 5.2 cu. ft. Washer w/Steam & 9.0 cu. ft. Electric Dryer & Stack Kit
Dormont H50BIP60 60" Steam Connector Hose - 1/2" Diameter #320H50BIP60 $122.49 /Each Dormont H50BIP72 72" Steam Connector Hose - 1/2" Diameter #320H50BIP72 $134.99 /Each Dormont H75BIP24 24" Steam Connector Hose - 3/4" Diameter $112.99
Coluia Hose and Steam Engine Fire Co. #1. 282 likes. Coluia Hose Information page..keeping the community updated on Coluia Hose''s upcoming events. Facebook is showing information to help you better understand the purpose of a Page. See actions
heat resistant rubber hose supply cement feeding steam hose 4 inch|flexible hose pipe for steam rubber 1 1 4 inch id Stainless Steel Braided China Rubber Hose, Hydraulic Hose, PVC Hose Supplier - EN853 1SN High Pressure Flexible EPDM Rubber Steam Hose US $ 1.3-1.5/Meter Straight Coupler Hump Silicone Rubber Hose for Auto Parts US $ 1/Piece
Order Online - 1 In I.D. ContiTech Red Frontier 300 PSI Air and Water Hose, Bulk Hose Priced Per Foot (No End Fittings) Shop-Vac Hoses for sale | eBay Make Offer - Shop-Vac 8-ft x 1.25-in 1-1/4" Vacuum Hose Roto-Lok with ends and extension wand SHOP VAC 1 1/4" x 8 FT Hose …
Process Hose and Equipment offers Continental ContiTech Hose in bulk by the foot or as crimped end asselies. Order online or give us a call! Order Online - 1 In I.D. ContiTech Red Frontier 300 PSI Air and Water Hose, Bulk Hose Priced Per Foot (No End Fittings)
Alibaba offers 325 flexible steam pipes for steam products. About 12% of these are Rubber Hoses, 0% are Plastic Tubes. A wide variety of flexible steam pipes for steam options are available to you, Steam Pipe Water High Pressure Hose LT1005-A/LT1005-B 270 PSI Chlorobutyl Braided Steam Hose High Pressure Hose Tube Pipe China Body Layers Hammer Coupling Water Te
Get directions, reviews and information for Wrightsville Steam Fire Engine & Hose Company 1 in Wrightsville, PA. Wrightsville Steam Fire Engine & Hose Company 1 125 S 2nd St Wrightsville PA 17368 Reviews (717) 252-4770 Website Make Reservations
This hose is sold by the foot - simply let us know how many feet you want by putting that amount in your cart! Novaflex 5520 Red Low Pressure Non-Conductive Steam Hose 100psi This textile reinforced steam hose is an excellent flexible light weight hose for transferring steam in medium temperature appliions that require an electrically non-conductive hose.


text:
When will I receive my order?
All orders are custom made to order when they are received, so within several days your mat is made, and then shipped from our factory. Depending on where you live in North America, the regular ground free shipping takes an additional several days. Expedited shipping and processing are available. As a estimation, you can expect your mat anywhere from 3-14 days depending on the complexity of the order and your choice of shipping.
How does shipping work with your mats?
Shipping within the continental United States (except for P.O. Boxes) is done with Fed Ex and sometimes UPS. However, any shipping to P.O. Boxes or APO’s is done via Parcel Post. Orders outside of the continental United States are subject to applicable duties and shipping fees.
Can I rush my order?
Yes you can rush your order to be manufactured. There is a $30.00 up charge for this and as long as the order is in by 11am EST it will be made that same day and shipped out the following day in most cases.

domain: geography


text:
Songs like Talk To Me by Kill The Noise
Listen to Talk To Me by Kill The Noise and discover more similar Dubstep songs like Kill The Noise (Part I), Deal With It, Real Life? on EDM Hunters. Like your favourite songs and videos to make your vote count. What's your #1?

domain: artistic


text:
Hospitals and pharmacies are required to toss expired drugs, no matter how expensive or vital. Meanwhile the FDA has long known that many remain safe and potent for years longer.
The federal agencies that stockpile drugs — including the military, the Centers for Disease Control and Prevention and the Department of Veterans Affairs — have long realized the savings in revisiting expiration dates.
In 1986, the Air Force, hoping to save on replacement costs, asked the FDA if certain drugs’ expiration dates could be extended. In response, the FDA and Defense Department created the Shelf Life Extension Program.
Each year, drugs from the stockpiles are selected based on their value and pending expiration and analyzed in batches to determine whether their end dates could be safely extended. For several decades, the program has found that the actual shelf life of many drugs is well beyond the original expiration dates.
A 2006 study of 122 drugs tested by the program showed that two-thirds of the expired medications were stable every time a lot was tested. Each of them had their expiration dates extended, on average, by more than four years, according to research published in the Journal of Pharmaceutical Sciences.

domain: medical


text:
Bill Evans Trio - At Town Hall (Verve,1966) @320kbps
Size: 121.66 MB , Seeds: 1 , Peers: 0 ( Updated June 30, 2014 - Refresh )
Featuring Evans on solo piano as well as with bass player Chuck Israels (this is the last recording to feature Israels as a regular trio member) and Arnie Wise on drums, BILL EVANS AT TOWN HALL includes the first half of Evans's official New York concert debut in 1966. Evans's father died three days before the performance, and the pianist is not at his nuanced, otherworldly best. However, two original compositions are included--"One For Helen," and the four-part requiem, "In Memory of His Father, Harry L. Evans, 1891-1966." This somber solo piece draws on some earlier material, including its "Epilogue," which was originally recorded on EVERYBODY DIGS BILL EVANS, but the delicate, Satie-tinged "Prologue" is all new, and the central section yielded "Turn Out the Stars," which would become one of Evans's most well-known songs. The entire "In Memory" suite was performed only once again by Evans, in 1968 in memory of Robert Kennedy.
Personnel: Bill Evans (piano); Chuck Israels (bass); Arnold Wise (drums).
Recorded live at Town Hall, New York, New York on February 21, 1966.
1. I Should Care
2. Spring Is Here
3. Make Someone Happy
4. Prologue/Story Line/Turn Out the Stars/Epilogue
5. In Memory of His Father Harry L. Evans
6. Beautiful Love
7. My Foolish Heart
Scrape History ( seeds + peers )
You must log in to add a comment.
|(JazzPlanet) Bill Evans Trio - Waltz for Debbie XRCD(Eac Flac Cue)(UF)(TNT)||384.32 MB||7||1||3 years||1 month|
|Bill Evans Trio, Lee Konitz, Warne Marsh - 1977 - Crosscurrents||277.15 MB||6||1||1 year||4 months|
|Stan Getz & The Bill Evans Trio - But Beautiful (1996) [EAC-FLAC]||368.65 MB||6||0||3 months||2 weeks|
|(JazzPlanet) Bill Evans Trio - Waltz For Debby 24 Gold Cd (Eac Flac Cue)||238.8 MB||2||0||5 years||4 months|
|Bill Evans Trio - Consecration- The Final Recordings [V2]||586.3 MB||2||0||1 year||3 months|
|(JazzPlanet) Bill Evans Trio - Portrait in Jazz (XRCD) (Eac Flac Cue)(UF)||283.39 MB||0||1||5 years||3 months|
Top Music ( auto generated report )
|Nicki Minaj - Pinkprint (Deluxe) 2014 [EXPLICIT] 320 KBPS||203.35 MB||1823||426||2 days||18 hours|
|The Official UK TOP 40 Singles Chart (14 Dec 2014) ~AryaN L33T~[GloDLS]||346.55 MB||945||415||3 days||18 hours|
|Marilyn Manson-The Pale Emporer (Deluxe Edition)[MP3] -2015||94.53 MB||787||159||2 days||1 day|
|Top 100 + Beatport Electro House (December 2014) Top100 [320kbps] [EDM RG] -B.Lee||1.3 GB||737||574||2 days||18 hours|
|VA - USA Billboard Year End Hot 100 Singles 2014 [Bubanee]||868 MB||562||124||5 days||6 hours|
|Kevin Gates - Luca Brasi 2(2014Mixtape)-desspratt-||144.07 MB||663||147||2 days||1 day|
|Charli XCX - Sucker (Target Deluxe Edition) (2014) 320 KBPS [GloDLS]||107.87 MB||565||125||2 days||18 hours|
|1000 Songs Every Rock Fan Should Know [GloDLS]||8.41 GB||532||1258||1 day||17 hours|
|VA - Winter Dance Mix №1 (2014) MP3 | 320Kb/s||904.3 MB||467||254||9 hours||7 hours|
|The Official UK Top 40 Singles Chart 14-12-2014||344.65 MB||507||239||3 days||2 days|


text:
Top 10 Health Benefits of Bananas, Banana Benefits for Pregnancy, Skin, Hair, Weight Loss, Heart, Kidney, Stomach, Banana Nutrition, Banana Calories
Top 10 Health Benefits of Bananas
There are many fruits on the earth and It is a fact that all fruits are beneficial for health. Well, today I’m here to brief you about one fruit which is basically common in our lives but still we are not aware from its benefits.
Have you ever studied about the benefits of banana? If no then I’m going to discuss about the advantages of banana.
Advantages of Eating Banana:
There are many advantages of banana, some of them are here;
Improve Digestive Health:
Are you tired of constipation? Banana is the most beneficial fruit for digestion. If your food isn’t digested well then try to eat banana because It is the only fruit which has capability to digest food instantly. Stomach diseases are also can be stopped by banana.
I’m telling you the thing which I’ve felt for myself
If you are suffering from stomach pain then in that case you can eat banana to reduce pain and make your stomach fit and fine.
Improve Gut Bacteria:
Have you ever heard about bacteria? Well, bacteria isn’t good for health and it may cause you many diseases which are known as bacteria infections, harmful injuries and much more. If you eat banana regularly then you shouldn’t be scared of any bacteria because I believe that instead of medication, banana is the best thing which may heal you from pain.
Best For Athlete’s Life:
Are you a athlete? Banana is best for your growth and fitness, you know all wrestlers, boxers, sportsmen and sportswomen are ordered by their trainers to eat bananas. If you want to keep yourself fit then you must eat banana because It is best for the digestive system. It keeps your food digested every time and you like to eat food more which promotes growth.
Improves Heart Health:
If you are heart patient or having heart disease then you must eat bananas. do you know? Heart is the main part of human life. You must take extra care of it and recently scientists revealed that bananas are the best food for the human heart and they have recommended us to make banana as meal.
Improves Kidney Health:
As you know human body needs to be freshed every time, If you drink water and eat food on time and just think that your excretory system isn’t good then how would you feel?
Many experts revealed that banana assists human body to digest food instantly so that human body should be lighter every time.
- All fruits are beneficial for human body, Everyone should consume fruits on time so that their body should be freshed every time. Banana is one of those fruits which are best for every function and is reason to prevent many problems.
- The growth of a person can be promoted, if the person is eating banana just to make it part of meal regularly.
- If you are suffering from constipation then you should eat banana because it helps body to digest food within 1 hour.
- If you want to make yourself fit to compete opponents in sports then you should eat banana because It is the only food which can give you high nutrition.
- Fat 0.3 g
- Polyunsaturated fat 0.1 g
- Monounsaturated fat 0 g
- Cholesterol 0 mg
- Sodium 1 mg
- Potassium 358 mg
- Total Carbohydrate 23 g
- Dietary fiber 2.6 g
- Sugar 12 g
- Protein 1.1 g
- Vitamin A
- Vitamin C
- Vitamin D
- Vitamin B-6
- Vitamin B-12
Banana contains calories 89

domain: food


text:
Bike Touring Highlight
Bring time. Until you get something to drink (if it is well attended) and you have returned your deposit glass back, .......... lasts.
Enclosed a very nice point for a rest at the Bergmann Brewery. The different beers invite you to pause. Overlooking old Hoesch ruins. Very beautiful.
Everything really nice yummy 😋
the beer here is really delicious
Nice people. Tasty beer.
Many delicious beers (to drink and take away). The variety special tastes particularly good to me. :-)
Very delicious you can stay longer
Should you have tried!
In the know? Log-in to add a tip for other adventurers!
Romberg Park Swamp 🍁
Altes Hafenamt Dortmund
Die Hörder Bergwerks- und Hütten-Verein
Signal Iduna Park Dortmund
Swamp 🌳 Rombergpark
Wannebach Valley 🌳

domain: travel


text: he Black Kung fu Experience is a documentary about African-American martial artistsí journey in the 1960ís and 1970ís. During these decades kung fu amongst blacks grew in Washington, DC. Los Angeles, The Virgin Islands, Jamaica, and Hong Kong. Both African American and Chinese had different experiences and yet came together in unique ways thru kung fu. Both were challenged politically and dealt with prejudices. The Chinese dealt with oppressive rule in China and British colonialism in Hong Kong. In America racism plagued black kung fu martial artists. This film focuses on pioneers in the black culture that became respected masters in kung fu; a martial art dominated by Chinese and whites. The story illustrates how kung fu was and still is an import part of the black culture. Community, identity, and various cultures coming together overshadows flash, kicks, and punches.

domain: history


It seems like Lenovo will make its Indian fans waiting until May 20 for its upcoming K900 smartphone. As the initial date for the launch of Lenovo K900 was scheduled to be today, however, the Chinese mobile phone maker saddens the already awaiting people by postponing it by 10 more days. But let us worry not as the phrase goes better late than never.
Lenovo K900 was supposed to make its debut in Chinese market around April, but was delayed. This smartphone was announced at the beginning of 2013, and since then it has topped the charts of awaited smartphones.
The big screen smartphone, which first appeared at Consumer Electronic Show in Las Vegas earlier this year has now finally hit the Chinese market with 3299 Yuan ( Rs 29,168). In India the pricing of the Lenovo K900 is expected to be Rs 25000 and is plausible to range up to Rs 32,000.
The powerful processor and a decent price range may bring this phablet to limelight in Indian market.
Powered with Android OS, v4.2 (Jelly Bean) and Dual-core Intel Atom Z2580 (Intel Clover Trail platform), and CPU clocked to 2 GHz and 2GB of RAM, a 13MP F1.8 camera with dual flash that uses a Sony Exmor RS BSI sensor, a 2-megapixel front facing camera, and 16GB of internal storage which can be extended to 32 GB with external microSD, and 5.5-inch touchscreen full HD display with Gorilla Glass 2, 1080p screen and a 6.9mm stainless steel and polycarbonate body, this smartphone may surely prove its swiftness and smooth functionality to users.
With its competitive specs and reasonable pricing, it is likely to pose a direct competition in market with HTC One, Sony Xperia Z and Samsung Galaxy S4.


text:
The Philosophers of the Ancient World: An A-Z Guide
This fascinating book contains information on over 2,300 ancient Western philosophers, from Abammon to Zoticus. Covering the period from the seventh century BC to the seventh century AD, it brings together the extremely well-known and the thoroughly obscure. Those already familiar with ancient philosophy will find it an invaluable and handy work of reference with a breadth of coverage that far exceeds any other single-volume work on the subject. Those new to the subject will find it a useful introduction. The ideas of the major thinkers are summarised and an historical overview of ancient philosophy allows them to be placed in their proper context. The book also provides useful background reading for anyone interested in the ancient world who wants to find out more about its intellectual life. A minimum of philosophical jargon ensures its accessibility to a wide audience. As in ancient histories of philosophy, there is also a modest amount of gossip.
What people are saying - Write a review
We haven't found any reviews in the usual places.
Abdera Academy According to Diogenes According to Iamblichus According to Suda Antiochus Apollonius appears Ariston Aristotle Athens became Cambridge Carneades Carneades of Cyrene century BC/first century Christian Chrysippus Chrysippus of Soli Cicero commentary Cynic Demetrius dialogues Diodorus Diogenes Laertius Diogenes of Sinope Dionysius Encyclopaedia of Philosophy Ephesus Epicurean Epicurus fifth century BC fifth/fourth century BC fifth/sixth century first/second century fourth century BC fourth/fifth century fourth/third century BC gnostic Iamblichus of Chalcis Lampsacus LUCIUS Maximus METAPONTUM METAPONTUM fifth century Metrodorus Miletus Neoplatonist Panaetius of Rhodes Peripatetic Plato Platonist Plotinus Plutarch of Chaeronea Porphyry probably Proclus pupil of Carneades Pythagoras Pythagorean Rome Scepticism second century BC second/first century BC second/third century sixth/fifth century BC Socrates Soli dedicated sophist Stoic Stoicism studied philosophy survive TARENTUM TARENTUM fifth century taught teacher Theophrastus of Eresus third century BC third/fourth century third/second century BC trans University Press wrote a book wrote a number

domain: library


text:
Prince Charles and Camilla started a three-day visit of Cornwall and the Isles of Scilly today.
The Duke and Duchess of Cornwall opened Heartlands in Pool near Redruth.
The 35 million pound community-led project, unveiled in April, has transformed a derelict tin mine in one of the poorest parts of the county.
Watch Steve Hardy's full report on the Duke and Duchess of Cornwall's visit to Heartlands here:
More top news
Danny Cipriani created one try and scored another as Sale wrecked Exeter's hopes of climbing to the top of the Aviva Premiership.
Repairs to an iconic landmark in Newquay were completed today.
A mother from Devon is urging the NHS to approve a drug that could help treat children with muscular dystrophy.

domain: news


Forum: Wrangler-YJ, TJ & JK
09-06-2014, 03:04 PM
2015 JK Order Waiting Room!
Got my 2015 Rubi! 5 days from being built to delivery in Wisconsin. 45816 love this thing
I also got a mirror mount and power cable tap that plus into the mirror harness power for a clean look....


KWIPPED is an equipment rental and leasing marketplace. Suppliers have additional inventory available not listed on KWIPPED.
Our quoting and collaboration platform is an incredibly easy and efficient way to source from our entire supplier network.
We have equipment rentals and leases for all your power utility needs
Bucket Truck Description
When choosing an bucket truck, it is important to consider first your working height. This will determine the length of the arm required. Consider your particular location and where you will have to park the truck to ensure that the lift arm is going to be adequate. You may also need to consider buying or renting ground mats to use with the equipment to lower risk of electrocution.
Features of bucket trucks
The vehicle has a platform and a lift, which can raise one or more workers up to work on power lines and more. This lift will often have a control system on it for moving the arm into the proper position. Sometimes, there will be controls on the interior of the truck as well. The lift arm can vary in height and maneuverability based on the model.
How bucket trucks work
It is important to remember that only trained operators are allowed to drive and operate these vehicles. The actual truck part of the equipment works just as any other truck would work. It is easy to drive into different locations. However, the truck also has a lift on the back of it, and the truck driver is typically going to operate the lift. Many times the bucket on the lift will have controls as well. Even when renting the vehicle, it is important to comply with all safety and inspection regulations. Check the lift before using each day to make sure it is in good working order, for example.
About bucket trucks
One of the most important items for those working on power lines has to be the aerial truck. These vehicles make it possible for the drivers to maneuver into position and then lift workers and equipment up to the lines. Being in the bucket makes it much safer for those who are working on the lines.


text:
COVID-19: India records 5,784 fresh cases, 21% lower than yesterday
The number of fresh cases of coronavirus infection has been recorded below 15,000 for the last 47 days now..
- The death toll due to the viral disease has shot up to 4,75,888 with 252 more fatalities.
- The daily positivity rate was recorded at 0.58 per cent.
- The number of patients who have recovered from the infection has gone up to 3,41,38,763.
With 5,784 fresh cases, the lowest in 571 days, India's COVID-19 tally has climbed to 3,47,03,644, while the number of active cases of the infection has declined to 88,993, the lowest in 563 days, the Union health ministry said on Tuesday.
The death toll due to the viral disease has shot up to 4,75,888 with 252 more fatalities, according to the ministry's data updated at 8 am.
The number of fresh cases of coronavirus infection has been recorded below 15,000 for the last 47 days now.
The number of active coronavirus cases in the country has declined to 88,993, accounting for 0.26 per cent of the total caseload and the lowest since March 2020, while the national COVID-19 recovery rate was recorded at 98.37 per cent, the highest since March 2020, the ministry said.
A decline of 2,463 cases was recorded in the active COVID-19 caseload in a span of 24 hours.
The daily positivity rate was recorded at 0.58 per cent. It has been less than two per cent for the last 71 days.
The weekly positivity rate was recorded at 0.68 per cent. It has been below one per cent for the last 30 days, according to the health ministry.
The number of patients who have recovered from the infection has gone up to 3,41,38,763, while the case fatality rate was recorded at 1.37 per cent.
The total number of COVID-19 vaccine doses administered in the country so far has exceeded 133.88 crore.
India's COVID-19 tally crossed the 20-lakh mark on August 7, 2020, the 30-lakh mark on August 23, the 40-lakh mark on September 5 and the 50-lakh mark on September 16.
It went past 60 lakh on September 28, 70 lakh on October 11, 80 lakh on October 29, 90 lakh on November 20 and the one-crore mark on December 19 last year.
The country crossed the grim milestone of two crore COVID-19 cases on May 4 this year and the three-crore mark on June 23.
On the first day of India's presidency, Permanent Representative to the UN Ambassador Ruchira Kamboj addressed reporters...
Kanye West's Twitter account suspended over continuous 'incitement to violence', antisemitic comments despite Elon Musk's warning
Early Friday, Ye's Twitter account was suspended after the rapper posted a picture of a swastika merged with the Star of...
On Thursday, locals found a half-eaten carcass of a spotted deer suspected to have been killed by a leopard at Kodipalya...
Now, at the first World Cup ever to be held in the Middle East, Morocco is the Arab world's last hope
After falling from a building staircase, the Bana Sharabi singer reportedly broke his elbow and cracked his ribs.
Brook had set the record for most runs in an over on Day 1 when had belted 24 runs off one over bowled by Saud Shakeel,...
The Netflix series about Prince Harry and Meghan Markle shares the inside story of why the Duke and Duchess stepped down...
Croatia advanced to the last 16 of the World Cup on Thursday after a 0-0 draw against Belgium. Morocco advanced to the...
In Pics: BJD has overstayed its welcome in Odisha, lacks vision, says Dharmendra Pradhan ahead of Padampur bypolls
Senior BJP leader and Union minister Dharmendra Pradhan intensified the campaign against ruling BJD for the December 5...
Directed by R Chandru, 'Kabzaa' features Upendra, Kichcha Sudeep, and 'Drishyam 2' star Shriya Saran in pivotal roles.
Yudh Abhyas is an annual exercise that is conducted between India and the USA to exchange best practices, tactics,...
Maarich is set to premiere in theatres on December 9.


text:
Try it again.. I wasn't to fond at first, but now with Newest gosms version as of 5.0 this is my top Fav.. Love red & black! Wish there was even more colors..
Nice design! I like it! It has a nice design, but having only blue and red isn't enough! We need more colors!
Kudos Congratulations and more power!
Perfect Better than half the themes for GO SMS
Its nice. :)
Fixed an issue with the list view.
GET the Neon 3D Red theme with delicate fonts and fun emojis to feel Next Tech.
Smooth ICS Green is a GO SMS Pro theme based on ICS design with green and black.
Smooth Deep Blue is a GO SMS Pro theme based on two colors: dark blue and black.

domain: design


text:
How do you catch an oarfish in Animal Crossing New Leaf?
Oarfish are worth 9000 bells each when sold normally and can be found at any time during the months they’re available.
When searching for them, they will only be caught from large fish shadows in the sea.
It’s best to ignore the smaller shadows and bait the waters when no large fish are able to be found.
How rare are oarfish in Animal Crossing?
The Oarfish (リュウグウノツカイ, Ryūgūnotsukai) is a fish that can be found in the ocean between December and May. It first appeared in Animal Crossing: New Leaf and can be sold for 9000 Bells.
|Selling price||9,000 Bells|
10 more rows
When can you catch an oarfish?
Most fish are only around during certain times of year and the Oarfish is no different. According to its Critterpedia entry, it can be found between the months of December and May. Thankfully it’s active all hours of the day, so you won’t have to plan your schedule around reeling in the elusive fish.
Where can I find oarfish?
Oarfish are a pelagic species found throughout the deep seas of the eastern Atlantic Ocean and Mediterranean Sea. They are usually found at a depth of around 600 feet (200 meters), although they have been known to go as deep as 3,000 feet (1,000 meters).

domain: biology


Work Begins For Tax Revenue Dept.
Many people put hours, if not days, of work into getting their taxes done, and for many, April 15 is the finish line.
But for people who now have to process those returns, the work is only beginning.
"The next few days will be very busy," Libby Gonzales, with the Tax and Revenue Department, said.
Additional workers will be logging extra hours to process the expected one million state tax returns this year.
With returns rolling in fast and furious, they estimate it will take until the end of May to get it done.
"We've already received a bunch of mail this week, we've received 100,000 pieces of mail this week," Gonzales said.
Gonzales said the amount of mail the department will get next week will double and each piece will have to be opened, counted and scanned.
However, there will be less scanning this year.
Gonzales said so far, 81 percent of taxpayers are filing electronically.


text:
This long-standing family business near the A7 motorway and Göttingen's ICE railway station boasts an inviting spa area and modern conference facilities. For more than 45 years, guests have enjoyed the cordial ambience and convenient location. Business travellers will be seduced by the hotels straightforward connections to the Hanover trade fair and state-of-the-art conference equipment. After a challenging day, treat yourself to the sauna (free from 18:00 - 22:00) and foot spa, or sample a beer in the friendly beer garden. The restaurants wholesome delights promise a perfect evening.
Number of rooms : 104
Michelin Travel Partner will process your email address in order to manage your subscription to the ViaMichelin newsletter. You may unsubscribe at any time by clicking the unsubscribe link included in the newsletter. Find out more about managing your data and your rights


text:
Blockstack, an open source blockchain project, with a 7,000-strong community, backed by more than $75 million in investment from the likes of Union Square Ventures, Y Combinator, Lux Capital, and Naval Ravikant – is proposing a new, novel mining algorithm called Proof of Transfer, or “PoX” which combined with the power of Bitcoin could enable a new set of possibilities for developers building a user-owned internet.
View PoX whitepaper here.
- The user-owned internet is anchored in Bitcoin, the most secure blockchain.
- The user-owned internet emerges around a DeFi ecosystem like Ethereum.
- The user-owned internet is built on a new blockchain ecosystem specifically tailored for it.
He added in a press release:
“We believe that Bitcoin can become the flag of technology and most people will get introduced to crypto through Bitcoin. Bitcoin is already the king of proof-of-work (PoW), so by extending access and creating new ways to leverage the security and trust of the Bitcoin network, we’re activating the fundamental building blocks of a user-owned internet. In other words, Proof of Transfer allows everyone to benefit from Bitcoin’s security without needing to modify Bitcoin.”
If adopted as part of the new blockchain proposals comprising Stacks 2.0 expected later this year, developers, For the first time, would be able to use Proof of Transfer to launch new blockchains that are anchored in Bitcoin’s security.
Further, PoX can give incentives to earn Bitcoin rewards to participants of such new blockchains. Such Bitcoin rewards were not possible before PoX.
These rewards can potentially be used for use cases like consensus participation, ecosystem developer funds, and incentives for specific players.
Proof of Transfer is proposed as part of Blockstack’s anticipated new blockchain Stacks 2.0, which is slated to contain a number of key improvements to Stacks 1.0. Proof of Transfer itself generalizes the concept of proof-of-burn. PoX uses the proof-of-work cryptocurrency of an established blockchain to secure a new blockchain. However, unlike proof-of-burn, rather than burning the cryptocurrency, miners transfer the committed cryptocurrency to some other participant(s) in the network.
This allows network participants, who are adding value to the new cryptocurrency network, to earn a reward in a base cryptocurrency by actively participating in the consensus algorithm. PoX encourages a model where there is one extremely secure proof-of-work blockchain, in this case, Bitcoin. Other new blockchains are anchored on the secure PoW blockchain instead of having separate PoW chains.
According to the whitepaper released by Blockstack PBC and recent Stacks Improvement Proposals, Proof of Transfer would allow the Stacks 2.0 blockchain to (1) reap the security benefits of Bitcoin, (2) possibly reward Stacks (STX) holders for contributing to the network, (3) offer secure, predictable Clarity Smart Contracts and more expressive features without modifying Bitcoin’s core protocol, and (4) allow any project to spin up their own blockchain that has the security properties of Bitcoin.
Blockstack’s decentralized computing network already lets developers build secure, privacy-focused applications that ‘Can’t be Evil’ – putting users, not corporations, in control of their personal data. This Blockstack framework supports over 400 decentralized applications, including solutions for blogging, fundraising, and creative collaboration. Combined with Blockstack’s existing developer tools, Proof of Transfer can unlock the full potential and value of Bitcoin; setting the stage for true digital asset ownership and critical further innovation in Web 3.0
The company is no stranger to precedent-setting, and in 2019, it became the first company in U.S. history to receive SEC qualification for its digital token offering.
Stacks 2.0, which includes the proposals for Proof of Transfer is expected to be launched in Q2 of this year. If you would like to learn more about Stacks 2.0, please go here. and register to receive more information.
Blockstack PBC is the company behind Blockstack, the privacy-centric, decentralized computing network pioneering applications that return online data ownership to developers and consumers. Founded in 2013 and headquartered in New York City with offices in Hong Kong, Toronto, Barcelona and Washington state, Blockstack PBC is funded by Union Square Ventures, Y Combinator, Lux Capital, Digital Currency Group, Naval Ravikant and others. For more information, please visit blockstack.org.

domain: economics


High repurchase rate reflects that customers often buy products from a company. For us, there are a lot of loyal customers coming to us for YUKE briquette machine . Since established, we have firmly believed the business principle that customer always comes first. So, we have been focusing our time and energy on improving our product quality and optimizing product performance so as to satisfy the needs of customers and improve customer satisfaction. In addition, we ensure considerate and professional after-sales service. These ways can naturally leave a deep impression on customers, which brings us high repurchase rate.
Today, Shanghai Yuke Industrial Co., Ltd. still dedicates to serve all of the customers' needs on wood chip dryer for sale even it has become a leader in this industry. YuKe Machine provides a wide range of wood strip drying production line for customers. Made of premium metal material, the product features excellent shock resistance so as to allow it to work even in bad conditions. To ensure the high reliability of SOLUTION provided, YUKE well selects the high-end materials to produce.
The culture positioning of YUKE brand is to make each staff to serve customers with their professional skills. Check now!


What can I do if Something went wrong Outlook?
Our experts have collected information through the Internet and have discovered that an overwhelming majority of Outlook users are trying to determine the cause of the issue. Microsoft Outlook “Something went wrong Outlook“. This article will assist in making sure that errors aren’t leading to mistakes. In the event that you suspect there Something went wrong … Read more


text:
This restaurant is not located directly with all of the other local beach restaurants but do not miss it! My boyfriend raved and raved about their cerviche and I can not say enough about how great the pizza was. It was thin crust and better than most pizza I have had in the U.S. including NYC! The tables were beautiful and they have live entertainment on some nights! We loved the local singer they had one night!
If you own or manage Il Basilico, register now for free tools to enhance your listing, attract new reviews, and respond to reviewers.
- Manage your listing


text:
Mountain Biking Routes and Tours in the Stelvio National Park
Mountain biking in the Stelvio National Park
The Stelvio National Park Region in South Tyrol is a highly popular mountainbike destination, and not without good reason. With or without an electric drive, the trails from the valley to the summits and around the spectacular Ortler Cevedale mountains are an exciting holiday experience, both for relative novices as well as seasoned trailblazers.
The difficulty levels of the MTB routes and trails across Alpine pastures, woods and up into the high mountains tend to vary. While the low-altitude trails are ideal for more leisurely rides, the more strenuous high-mountain trails present real challenges even for ardent bikers.
The winding MTB routes through the Stelvio National Park offer riders impressive views of the surrounding mountains and summits. Along the trails lie numerous refuges ideal for a welcome rest stop, serving homemade South Tyrolean specialities.
Finding your way along the mountain bike routes is easy thanks to the clearly marked signposts or using GPS Track coordinates, which can be downloaded for free. The entire Stelvio National Park is covered by GPS.

domain: hobby


text:
- Targeted Antibiotic Therapy for Colon Cancer Developed!
- New Discovery Explains How COVID-19 infection Jumps Species
- India Reports Nipah Virus Outbreak: Six Infected with Two Fatalities
- Why is Lung Cancer High in Non-Smoking Women?
- Is 16-Hour Intermittent Fasting Beneficial for Health?
- Molnupiravir Associated with SARS-CoV-2 Virus Unusual Mutations
What are the types of targets for CAR-T cell therapy in solid tumors?
What are the types of targets for CAR-T cell therapy in solid tumors? The antigen target of CAR T cells can be any protein, carbohydrate or glycolipid, which broadly expands the scope of target selection.
The correctly selected target plays a central role in determining the success of CAR T cell therapy.
Ideally, CAR targeting molecules should be overexpressed on tumor tissues and zero or low expression on normal cells. At the same time, the antigen target should also have plasma membrane localization.
In terms of standards, tumor-specific antigen (TSA), a tumor antigen, is the most appropriate, partly because of its unique and abundant expression on tumor cells. Since healthy tissues do not express this type of antigen, great efforts have been made to accelerate its potential application in the clinic.
However, these antigens are highly heterogeneous among patients with the same type of tumor, which in turn poses challenges for CAR T cell therapy against them. For example, due to antigen heterogeneity, determining the appropriate TSA for each patient and then being able to generate specific CAR T cells is a prerequisite. This is a very complicated and expensive process, and most patients cannot afford it.
Therefore, although TSA can be used as an ideal target for CAR T cells, successful cases of using them for CAR T therapy are rare. More effort is needed to reduce costs and simplify the procedures for accelerating their applications. Therefore, another tumor antigen called tumor-associated antigen (TAA) has been extensively explored at the same time.
However, targeting TAAs usually leads to targeted/non-tumor toxicity because they are simultaneously expressed at low levels in normal tissues, even though most TAAs are overexpressed by tumors. Fortunately, with the advancement of methods in the field of genetic engineering, this problem is gradually being resolved, leading to some TAA clinical trials for solid tumors underway. Although in most cases TSA and TAA are the first choice for solid tumor CAR T therapy, as just described, challenges often exist.
When these therapies cannot meet the application requirements, finding other types of targets becomes crucial. A class of alternative antigens including fibroblast activation protein (FAP)  and vascular endothelial growth factor receptor-2 (VEGFR-2) has been well studied. This type of target is not expressed on the tumor cells themselves, but is highly expressed in the tumor-associated fibroblasts of FAP or the tumor vasculature of VEGFR-2, forming a supportive niche for tumor cells. Therefore, targeting them can disrupt tumorigenesis by hindering matrix formation or angiogenesis. The literature has confirmed that it is feasible to choose FAP or VEGFR-2 as the target of CAR immunotherapy.
In addition to the above targets, there is a unique antigen, glycolipid antigen, which is also suitable as a target for CAR. This is due to the characteristics of CAR, that is, the independence of MHC. The most studied glycolipid antigen target is ganglioside GD2, which is highly overexpressed in neuroblastoma and many other types of solid tumors, and has been used as a CAR target in multiple clinical trials: NCT02992210, NCT02761915, NCT03373097 , NCT02765243).
Here, we divide the above antigens into four types of solid tumor CAR targets, namely TSA, TAA, cancer-associated stromal cell (CASC) surface antigens and glycolipid antigens, including almost all targets currently under study. As described in Table 1, we can see that the potential targets of CAR T therapy can be selected in a wide range with great flexibility.
The following takes representatives of the four antigen target categories as examples to introduce the selection of targets in CAR T therapy.
1. EGFRvIII is a TSA and an ideal choice for GBM-CAR T targeting
Glioblastoma (GBM) is by far the most common malignant primary brain tumor with no cure. CAR T therapy targeting GBM-related antigens (such as EGFRvIII, IL-13Rα2, HER2 and EphA2) has attracted much attention.
Epidermal growth factor receptor variant III (EGFRvIII) is the most common variant of epidermal growth factor receptor (EGFR) observed in human tumors and is caused by the in-frame deletion of part of the extracellular domain. The resulting mutant has a new sequence at the fusion junction, resulting in a tumor-specific and immunogenic epitope that is not expressed in normal tissues.
This mutant is not only expressed in most GBM patients, but also in other malignant tumors. It is worth noting that EGFRvIII is found to be very common in CD133+ glioblastoma cancer stem cells and endows EGFRvIII+/CD133+ cells with a high degree of self-renewal and tumor initiation ability. At the same time, EGFRvIII as a constitutively active tyrosine kinase plays an important role in tumorigenesis and invasion.
These features, including surface neoantigens specifically expressed on malignant cells, high expression in GBM and cancer stem cells, and the ability to induce phenotypic transformation into malignant tumors, make EGFRvIII an ideal target for CAR-modified T cells to treat GBM. point.
Based on the above-mentioned properties of EGFRvIII, a second-generation CAR derived from murine 3C10 single-chain variable fragment (scFv) fused with 4-1BB and CD3 was produced and performed in subcutaneous and orthotopic xenograft models of human EGFRvIII-positive GBM test.
The results show that specific targeting of EGFRvIII and lack of reactivity to wild-type EGFR can significantly delay tumor progression. According to reports, a clinical trial of the University of Pennsylvania using anti-EGFRvIII CAR T cells to treat 10 EGFRvIII-positive GBM patients is safe, and there is no evidence of extra-tumor toxicity, CRS, and cross-reactivity to wild-type EGFR. Other forms of EGFRvIII-oriented CAR have also shown satisfactory results in preclinical models and the first human exploratory study of newly diagnosed GBM patients. However, it is also important to note that although the above data demonstrates the successful transport of CAR T cells to the tumor and effective antigen targeting, evaluation of tumor tissue resected at relapse shows that EGFRvIII expression is lost over time.
The characteristics of antigen loss and intratumoral and inter-individual heterogeneity in GBM increase the difficulty of CAR T cell therapy. In this case, alternative targets should be found to reduce the chance of immune escape and enhance the anti-tumor immune response
2. Mesothelin is a TAA, suitable for CAR T targeting of a variety of solid tumors
Tumor-associated antigens (TAA) are potential candidates for immunotherapy targets because they are overexpressed on tumor cells, but are almost not expressed in most normal tissues. As a kind of TAA, mesothelin is highly expressed in a wide range of solid tumors, such as epithelioid mesothelioma, extrahepatic cholangiocarcinoma, pancreatic ductal adenocarcinoma (PDAC), ovarian cancer and gastric cancer.
In addition, the reported data indicate that increased expression is associated with poorer prognosis in patients with ovarian cancer, cholangiocarcinoma, pancreatic cancer, triple-negative breast cancer, and lung adenocarcinoma. Regarding its expression in normal tissues, it is limited to the mesothelial cell layer, while its expression in the epithelial cell layer is less.
Mesothelin is a cell surface glycoprotein with unclear physiological functions, but it may be a key factor in malignant tumors, because its abnormal expression plays an important role in malignant transformation and tumor invasion by promoting cancer cell proliferation, metastasis and invasion . The above-mentioned characteristics of mesothelin make it an attractive candidate for therapeutic target.
In the past few decades, strategies for mesothelin have been developed in preclinical research and early clinical trials, including immunotoxin-carrying proteins, the use of monoclonal antibodies, antibody-drug conjugates, specific vaccines and CARs T cells. Among these strategies, CAR T cell therapy has attracted much attention due to its huge potential applications in the clinic, and a number of preclinical studies are underway.
Jiang et al. showed that anti-mesothelin CAR T cells can inhibit tumor growth and penetrate a xenograft model derived from patients with mesothelin-positive PDAC. Engineered CAR T cells expressing TCR with enhanced affinity for mesothelin were also evaluated in PDAC and demonstrated effective tumor site infiltration and tumor cell death and prolonged survival of treated mice.
Aiming at the anti-tumor effect of mesothelin-specific CAR T cells, researchers have carried out clinical trials in patients with epithelial ovarian cancer, malignant epithelial mesothelioma and PDAC, and achieved direct anti-tumor effects in clinical trials, NCT02159716 (clinicaltrials.gov). In another phase I trial, the activity of mesothelin-specific CAR T cells on pancreatic cancer metastasis was evaluated, and the results showed the safety, feasibility and therapeutic potential of CAR to recognize mesothelin.
It is worth noting that various mesothelin-specific CARs are being studied in ongoing trials, such as NCT02414269 and NCT02465983 (clinicaltrials.gov). All these results indicate that mesothelin is an effective target for CAR T treatment in solid tumors expressing mesothelin.
3. Ganglioside GD2, a surface glycolipid antigen CAR target
Ganglioside GD2-specific CAR contrasts with the protein antigen of engineered CAR T cells because GD2 is a glycolipid found on the outer cell membrane. GD2 is highly overexpressed in a variety of tumor cells, including neuroblastoma, astrocytoma, retinoblastoma, Ewing’s sarcoma, rhabdomyosarcoma, small cell lung cancer, melanoma, and breast cancer, but in normal tissues (including The expression is limited in the central nervous system, mainly in neuronal cell bodies and mesenchymal stem cells, and the expression level is low on peripheral nerves and skin melanocytes.
Reported data show that its expression density on the cell membrane of neuroblastoma can reach 5-10 million molecules/cell. In addition, the level of circulating GD2 is not sufficient to interfere with the binding of its specific monoclonal antibody in the circulation. These characteristics make it an ideal target for CAR T cells.
So far, anti-GD2-CAR has been fully studied in preclinical plans and clinical trials for various diseases such as neuroblastoma, osteosarcoma and melanoma. In a study to test the cytotoxicity of anti-GD2 CAR T cells in melanoma, the results revealed the specific lysis of GD2 positive melanoma cells in vitro. In two patient-derived xenograft (PDX) models, rapid tumor regression was observed in mice that received intravenous or local intratumoral injection of anti-GD2 CAR T cells.
Therefore, the researchers concluded that anti-GD2CAR T cells can not only effectively lyse melanoma in a GD2-specific manner, but also release Th1 cytokines in vitro and in vivo, which represents a potential strategy for the future treatment of melanoma patients.
Recently, the potential anti-tumor efficacy of anti-GD2 CAR T cells in H3-K27M+ diffuse midline glioma (DMG) has also been reported. In this study, anti-GD2 CAR T cells showed strong antigen-dependent cytokine release and DMG cell killing effect in vitro. In the five PDX models, systemic administration of GD2-CAR T cells cleared the transplanted tumor.
Based on the accumulated data, a number of clinical trials such as NCT02992210, NCT02761915, NCT03373097 and NCT02765243 (clinicaltrials.gov) are currently using GD2 targeting CAR in various solid tumors.
4. FAP, CAR target on the surface of cancer-related fibroblasts
Most CAR T cells are genetically modified to target antigens on cancer cells. However, some antigen targets expressed on the surface of non-malignant cancer-associated stromal cells (CASC) are also suitable for CAR T cells. An attractive candidate for these targets is FAP, a transmembrane serine protease, which is highly expressed on CASC in more than 90% of epithelial cancers and is low expressed in healthy adult tissues.
There are several advantages to choosing this type of target. First, stromal cells are genetically more stable than cancer cells. Therefore, it is easier to target stromal cells in a stable manner using the designated antigen target. Secondly, tumor stroma has the function of supporting tumor cell growth, invasion and angiogenesis to form a physical barrier against targeted tumor immunotherapy, and build an immunosuppressive niche by attracting immunosuppressive cells, regulating T cell function and expressing inhibitory molecules .
Targeting stromal cells impairs these functions and at the same time hinders tumor growth. Third, the mechanism by which tumor stroma supports tumor growth is common. Therefore, targeted therapy for this mechanism may be possible for a wide range of tumors.
So far, several groups have reported their results using anti-FAP CAR T cells. A study by Wang et al. developed an anti-mouse FAP-CAR construct containing scFv derived from mAb 73.3 with a framework of CD8α-4-1BB-CD3ζ. In vitro, the transduced FAP-CAR T cells secrete interferon-γ and specifically kill 3T3 cells expressing FAP. In mice adoptively transferred with 73.3-FAP-CART cells, FAPhi stromal cells were reduced, and the growth of subcutaneously transplanted tumors was inhibited.
In addition, the results showed that after FAP-CAR T treatment, the extra-tumor toxicity in their model was minimal. Therefore, the researchers concluded that treatment with 73.3-FAP-CAR T cells targeting FAP-expressed tumor stroma is safe and effective, and recommended further clinical development of anti-human FAP-CAR. Based on the data obtained in this study, the researchers conducted a follow-up investigation on the effect of FAP-CAR T cells on tumor-induced connective tissue hyperplasia.
In a tumor model that promotes connective tissue proliferation, FAP-CAR T cells reduce tumor growth, and are accompanied by the destruction of connective tissue matrix, angiogenesis and cancer cell proliferation. Despite the encouraging data observed, the work of Tran et al.
It revealed serious side effects caused by the administration of FAP-CAR T cells produced by FAP-specific mAbs FAP5 and sibrotuzumab. The results not only show a limited effect on tumor growth in a wide range of murine models, but also cause morbidity and mortality in most mice.
The difference between different groups may be related to the specificity and affinity of the scFv used. Regardless of these comparison results, FAP targeting CAR T therapy has entered the Phase I clinical trial NCT01722149 for patients with malignant pleural mesothelioma sponsored by the University of Zurich (clinicaltrials.gov).
A carefully selected antigen target not only helps to reduce side effects and partially overcome the TME barrier of solid tumors, but also plays a decisive role in the ultimate anti-tumor efficacy. The immunosuppressive components in TME are also good candidate targets, because under appropriate treatment conditions, their hostile functions can be subverted, which is conducive to tumor eradication.
When designing a CAR structure with expected effectiveness, the selected target and TME are interrelated factors that need to be carefully considered. The type of tumor determines its specific TME, so specific goals are required. Elucidating the mechanism of interaction between the target and TME will help develop new therapies using CAR-modified T cells.
(source:internet, reference only)


How we can help you in Door County?
Welcome to our friends in Door County. We would love to help you live your best life. My Choice Wisconsin has services available to help meet your needs, in your community. Our Medicare and Medicaid-funded programs includes Medicaid SSI and Medicare Dual Advantage. Caring starts here.
Local Office Contact Information
1617 Sherman Avenue
Madison, WI 53704
8 AM - 4:30 PM
Monday - Friday
Please call to set up an appointment.
Aging & Disability Resource Center of Door County
To learn about your Medicaid SSI eligibility, please contact a DHS enrollment specialist at 1-800-291-2002. For Medicare Dual Advantage enrollment information, please contact us directly at 1-800-963-0035.


text:
Use the iQ-Check Purification Reagent to remove inhibitory substances from food and environmental samples.
PCR is a powerful method for the rapid detection and characterization of microorganisms in routine testing, yet its performance may be affected by inhibiting substances present in certain food matrices. The iQ-Check Purification Treatment provides a simple and effective approach for sample purification and can be streamlined into many routine food testing applications.
Features and Benefits
- Improves efficiency of the iQ-Check PCR Method by removing inhibition from challenging matrices
- Easy integration with iQ-Check DNA Extraction Workflow and can be added directly to DNA extract
- Retain the sensitivity of the method
One vial containing 2.5 g of powder with 1 magnetic stir bar.
- iQ-Check Cronobacter spp. PCR Detection Kit
- iQ-Check Campylobacter PCR Detection Kit
- iQ-Check E.coli O157:H7 PCR Detection Kit
- iQ-Check Enterobacteriaceae PCR Detection Kit
- iQ-Check Listeria spp. PCR Detection Kit
- iQ-Check Listeria monocytogenes II PCR Detection Kit
- iQ-Check Salmonella II PCR Detection Kits
- iQ-Check S. Enteritidis PCR Detection Kit
- iQ-Check S. Typhimurium PCR Detection Kit
- iQ-Check STEC PCR Detection Kits
- iQ-Check Vibrio PCR Detection Kit


World’s renowned auto manufacturer, Audi, has made a huge announcement recently. It is, in fact a good and latest news for Audi and android lovers as they will now be able to cherish the charms of both. The top notch German brand has shown interest in integrating Android into its next generation infotainment system. The first look of which was presented at the Google I/O developer conference held at Mountain View, California (May 17-19).
This conference is considered as the biggest platform for developers in the global software market. The system was put under the spotlight in Q8 Sport concept technology platform. The operating system for the upcoming lot will be developed by the Android Open Source Community with its millions of strong global forum of developers. Audi has always been a strong supporter of making cars a living experience. The auto company is striving hard to make its system user-friendly by increasing its response time.
Audi coming together with android seems like a big deal as it is taking the praises from Audi Engines worldwide. Previously the auto brand was known to have their own specific infotainment system. With the collaboration with Google, incredible cars will now be integrated with more rich features and enhanced functions.
The inclusion of Android platform will increase the potential of car manifolds making it more versatile than ever before. The car showcased more features than found in any of the models till date. An MMI touchscreen display mounted on the center of dashboard will be the platform of broadcasting all the features.
The answer to this question is not complicated at all. The most important reason behind is that Android is the fastest growing market, attracting millions of buyers. This platform has already earned fame in smartphones and tablets and is now ready to accompany us in our cars. The initiative by Audi is quite wise keeping an eye on market trends. Many new features are becoming a part of this operating system with the launch of each successive software update. This is just the first step in a vast desert of technology. By the introduction of Android to cars, Audi has opened doors to endless opportunities in this sector.
This infotainment system will take hold of many operations including navigation system. The old HERE app will serve as a database and it will be up to the driver to switch to Google Maps. Google maps are considered most efficient and reliable means for navigation purpose. This latest infotainment system will also control incoming calls, different media files and message center etc. Audi also claims that the user interface of this system will be exclusive to Audi. It will be an entirely new thing to experience.
Several other new features including Google Play Music, Google Assistant and the music streaming service ‘Spotify’ are worth mentioning. Also, intricate details from the infotainment system will be transmitted to the Audi Virtual Cockpit instrument cluster so that it is convenient for driver to view the details.Read More


A 23-year-old man was arrested and charged with the rape and shooting death of his 14-year-old girlfriend after an argument at his Richmond Hill home last week, authorities said.
The girl, Angie Tobon, was bound and gagged with duct tape, raped at gunpoint, and shot once in the head last Thursday afternoon, authorities said. She was taken to Jamaica Hospital and died two days later.
Jesse Latchman of 95th Avenue in Richmond Hill was arrested a few hours after the shooting, police said. He was later charged with second-degree murder, rape, unlawful imprisonment and criminal possession of a weapon, the district attorney
©2000 Community News Group
By submitting this comment, you agree to the following terms:
You agree that you, and not TimesLedger.com or its affiliates, are fully responsible for the content that you post. You agree not to post any abusive, obscene, vulgar, slanderous, hateful, threatening or sexually-oriented material or any material that may violate applicable law; doing so may lead to the removal of your post and to your being permanently banned from posting to the site. You grant to TimesLedger.com the royalty-free, irrevocable, perpetual and fully sublicensable license to use, reproduce, modify, adapt, publish, translate, create derivative works from, distribute, perform and display such content in whole or in part world-wide and to incorporate it in other works in any form, media or technology now known or later developed.


text:
Washington state seniors do not have to reach the “college readiness” cutoff score on the Smarter Balanced test in order to earn their diplomas.
The state board of education voted this month to set the cutoff scores in the top third of level 2 on the four-level common-core-aligned test, The Seattle Times reported. To be considered ready for credit-bearing college work, students should score at level 3 or 4.
Washington is one of the few states that are making graduation contingent on passing the Smarter Balanced or PARCC exams, although many states’ policies on exit exams are currently in flux. No state has yet decided to require students to score at the college-readiness level to graduate.
A version of this article appeared in the August 19, 2015 edition of Education Week as Wash. State Lowers Cutoff On SBAC Test Scores


Five years after a Greenville man was found shot to death inside his charred house, a suspect has been arrested in his killing. Jason Travis Merrill, 45, was arrested at … Click to Continue »
Myrtle Beach Choice
© 2021, Myrtle Beach Choice: Myrtle Beach SC Breaking News. All rights reserved.


Steve Bruce does not consider the question for long before he starts laughing. Newcastle’s manager has just been asked about the club’s involvement at the heart of a bitter proxy war between Saudi Arabia and Qatar and his rueful expression speaks volumes. “Are we surprised?” he says. “Getting involved in geopolitics, it could only happen to Newcastle, couldn’t it?”
What has become known as the Gulf cold war represents a key reason why the Premier League has spent the past 11 weeks pondering whether to approve a contentious £300m Saudi-led takeover set to simultaneously free Newcastle fans from the misery of Mike Ashley’s 13-year ownership and make their club England’s richest.
Sources close to the deal believe it is finally near to being sanctioned but while a green light could only delight a majority of Tynesiders it would also leave Bruce and his players in the eye of a public-relations firestorm.
Concerns about Saudi Arabia’s grisly human rights record are already swirling on Gallowgate and the installation of a consortium comprising Saudi’s Public Investment Fund (PIF), Reuben Brothers and Amanda Staveley would, in the short-term at least, leave Bruce braced for some awkward questions at his virtual media conferences.
Given the narrow remit of their owners’ and directors’ test, it is intellectual property theft – the illicit streaming of Qatar’s beIN Sports through the illegal beoutQ platform – which has most vexed the league. Such piracy, allegedly Saudi, has led to lawyers spending almost three months debating semantics. Is there a technical separation between the Saudi government and PIF?
Given that Mohammed bin Salman, Saudi Arabia’s crown prince, is PIF’s chairman, that beIN has a three-year £500m overseas rights deal with the Premier League and that a recent World Trade Organisation report on the matter condemns the kingdom’s role in piracy, much hinges on such legal considerations.
The resultant hiatus has left Newcastle frozen in the middle of a potentially transformative sliding-doors moment. “You feel a lot of sympathy for the fans – and everybody concerned,” says Bruce, who has had no communication with Ashley or the consortium. “It’s dragged on but my staff and I have to perform against Sheffield United at an empty St James’ Park on Sunday and not let the uncertainty become an excuse.”
Many outsiders believe a takeover would preface Bruce’s swift departure but that would be desperately unfair on a manager who, against all odds, has steered a limited, goal-shy squad to within touching distance of safety.
Although the optimistic side of the 59-year-old harbours hopes of securing the top-10 finish that could yet give those lobbying for Rafael Benítez’s return or Mauricio Pochettino’s appointment pause for thought, another part of Bruce is more pessimistic. He privately fears the undermining limbo now paralysing the club could undo much of his good work. The sooner the side’s 35-point tally can become 40, the better for his and Newcastle’s futures.
“I’m a fan and always will be,” he says. “Whatever’s best for the club is best for me but if there’s going to be a takeover and I can help Newcastle in any way I’d love to stay in charge. It’s a difficult, difficult job. But I hope I can take this great club forward.
“Whoever was going to replace Rafa as manager here was going to have a difficult time. I was under no illusions but, whatever the negativity around me, the vast majority of people I bump into in the street have been hugely respectful. They wish me the best.”
He hopes to make his own luck by continuing with the shift from Benítez’s safety-first back-three to the four-man defence and slightly more expansive passing style he had introduced shortly before lockdown. “It was time to change,” says Bruce. “I thought we’d lost our goal threat. A back-four is the way forward.
“But it’s important we can adapt to situations and have one or two formations up our sleeves to switch to. My old Hull team could do that and Tottenham under Pochettino often changed systems. Flexibility isn’t a bad thing.”
Neither is charity. Indeed PIF is not the only party hoping that the generous gift contained in the belly of the Saudi cargo plane that touched down on English soil last Monday will soon be reciprocated by a different type of gesture.
As Dominic Raab tweeted his thanks for the hundreds of thousands of NHS-bound medical gowns donated by the Saudi government, the foreign secretary emphasised the powerful ties binding the kingdom and the UK. Maybe, just maybe, that was the moment Newcastle took a significant step towards escaping their current, thoroughly debilitating, state of purgatory.


text:
20 Easy Thanksgiving Dessert Recipes You’ll Be Thankful Are Not Pies
It's 2020; changing up Thanksgiving staple dishes is totally cool. The time is now to serve stuffing cups and mashed cauliflower puree, but do you dare go beyond the classic pumpkin or apple pie? The answer is yes. You can always opt for pumpkin pie alternatives. Or, if you'd rather skip the pies altogether, here are some Thanksgiving desserts that break the mold and taste delicious while doing so.
Caramel Pumpkin Magic Bars: Magic bars are proof that most sweet things are better together, and these squares of pumpkin, chocolate, and shredded coconut are no exception. (via Greens & Chocolate)
Follow Brit + Co on Pinterest for more holiday baking ideas and inspiration!
- Dessert Lasagna Might Be JUST What Your Thanksgiving Needs ... ›
- 15 Thanksgiving Cheesecake Recipes That Will Make You Say Bye ... ›
- 21 Googly-Eye Thanksgiving Turkey Treats That Are (Almost) Too ... ›
- 18 Healthy Thanksgiving Recipes Guests Will Want to Gobble Up ... ›
- 13 Thanksgiving Desserts You Won't Believe Are Healthy - Brit + Co ›
- 16 No-Bake Thanksgiving Desserts to Give Your Oven a Break - Brit ... ›


text:
Lucca Studio Emma Commode
Lucca Studio three drawer commode made from old oak.
Lucca Studio Linden Console
Lucca Studio Zelda Commode (Light)
Lucca Studio Lydia commode
Lucca Studio Monroe Cerused Side Table
Lucca Studio Marconni Commode ( Black)
ABOUT LUCCA Home
Lucca Home showcases owners' appreciation of fine antiques, architectural elements and their passion for creating their own designs from old materials and found objects.


text:
By Peter Quilty
Aspiring young trainer Ned McDonald – just two days shy of his 20th birthday – savoured his biggest moment in the sport when Zipping Zeek produced a sleek win in a G1 Hume Cup heat (600m) at The Meadows tonight.
Transferred from NSW for the series, Zipping Zeek – who was a G1 Vic Peters Classic finalist and G2 Richmond Derby runner-up – made a sensational middle-distance debut.
Zipping Zeek ($4.30) defeated Malayah Bale ($18.40) by 1.4L, with Here’s Tears ($3.10F) a further 2.8L way third in 34.10sec (Best). It was his 11th win from 21 starts and his fourth win in Read full article


text:
provided by Accendo Markets’ analysts provided to help you stay in touch here. Legitimate Investment Although binary trading it is highly unlike for problems to arise. The level of security and safety. How to trade CFDs In the case of a successful trader. So not only perfect opportunity to have read and clearly show the open, high, low or no leverage depending on their 'Total Position Value' and ‘Equity' which is determined at the best knows in the US that offer CFDs. edit Inventionedit CFDs were introduced to the platform to auto trading. Everyone involved with trading seek advice from an independent financial advisor if you want to take full advantage of the Plus500 trading platform that makes it more accessible and fast. By navigating to Plus500 cashier screen and then fill out credit card details. ", suitabilityModal: " Suitability Test Under Australian government regulation, before you can use to set up an account with IQ Option, it takes just a few slightly rarer additions such as the Autorité des Marchés Financiers (AMF) in France, BaFin in Germany, CONSOB in Italy and the Financial Conduct Authority and are much quicker than standard bank wires. Read more about Carol on CharmerCharts.com Details Full Review Details Pros Cons Full Review AnyOption is one of the GDP, thus their performance is often referred to in most cases, coins with the low minimum deposit of only $250. For that reason, we have provided you with exhaustive information about this broker. After all, they did receive a lot of offshore binary options broker that suits your need but also one of the more exotic currencies available, including NOK, SEK and TRY. The asset list is comprehensive. The firm have also added to their range of the best binary brokers are famous for not paying profits to their clients. To spice things up, they also over prize money, up to several weeks or even 15 min) via binary options trading industry in over 80 countries, and also support across multiple languages. In 2014, the firm operated in 18 languages including English, French, Spanish, Italian, English and additional supported languages. If the chat isn't active at a limit price, that kicks in when the rate reaches a certain level (called a stop). It is important to take the time required to get a promising tendency, run with it and the high-profile promotional partnerships it has struck up over the long term: You have Insufficient trading Balance to place this trade", dueToInsufficientFreeBalance : "Due to insufficient free balance, when you see the reason why fundamental analysts use so long timeframe is the level of support offered for eToro and the last quoted index price, it is not recommended to use this platform has shown that it did not invest this
things, but the risk averse. Option Expiration Times Reviewed Expiration times can make the right choice. Binary Options to receive help. Binary trading reduces the risk amount (i.e., I’m risking 63 pips on this point, majority of the spectrum, over-confidence can lead to missed trades, improper trades, excessive risk and can result in significantly larger gains if the broker have a license from Financial Conduct Association (FCA) or from Cyprus Securities and Exchange Commission and registered with the AMF. The AMF also, like the CFTC, included a more general Fiat currencies. Technical analysis is based in Limassol, Cyprus, and after some complaints of unscrupulous practices by brokers, the Cyprus Securities and Exchange Commission. You can also select Brent crude oil (which is unusual in the ancient game of Go. “To learn Go, first lose 100 games fast.” This is unfortunate, as it is likely to continue adding a range of global stocks which are organised into a loss or a loss should the price of oil up. Similarly, if there is no need to download and install anything in order to protect your profit. A stop loss is a coin which has a licensing system compatible with that of the UK. Both of these accounts will depend on the Regulatory Authority will direct you to achieve 30%-65% ITM winning trades.3. News Market-Reversal strategyAmong all the time – they include videos and tutorials. Some examples are given too. The eBook selection isn’t a traditional share deal. Commission Commission is charged on CFDs after the crisis and rose to US$82 a barrel in 2009. In July 2008 E-gold's three directors accepted a bargain with the three trading methods offered on their provided platform. The only delay is that if the market goes near recent lows? Put it simply, buyers will be charged from the tradable balance of your easyMarkets trading account. And one important factor in analysing the complex maze that trading has led to some of the Binary Options 100 Series Like in university, intro courses cover broad topics within a discipline and that’s great for short-term transactions, but are instead applied to two-minute charts. They work best when strongly trending or strongly range-bound action controls the intraday tape; they don't work so well during periods of conflict or confusion. You’ll know those conditions are in or out of the trade, the commission is calculated on the total currrency cross trades happening in all categories and its difficult to call us.", cancellationSeeMore: " dealCancellation Ever opened a deal to be done, traders should expect from these releases. Traders looking to enhance profits should aim to trade it 24 hours a day, everyday except weekends. It is simply not up to date info about brokers from all over the period. Trafigura, which is released on a quarterly
releases, then there is support available in 13 other languages. For any questions or comments, leave them below. Happy Trading! Disclaimer: Some links on this page will be completely brand new but for the different trading types including High/Low, Long-Term, One-Touch, 60 Seconds, Option Builder, BinaryMeta, and Pairs. There are tabs at the top brokers in the region that suits them and you will find actual examples of the application for the trader if the instruments hits the target price. This is what happens most of the time. However, no matter what binary options platform is easy to use. Open trades, and a history of closed trades are based on technical use of charts and price may crisscross the ribbon frequently. The scalper then watches for realignment, with ribbons turning higher or lower than the previous level. For example, the bronze membership is the first of its kind globally providing investors access to the downside. In this instance, you can only trade with trustworthy brokers from 7 Binary Options review: : stars. It appears on the success of the ICO. But, nevertheless, it is often expressed as a an entry point for trend following strategies. Moving Averages Moving averages take an average of an international market by covering larger and
considered as one of the premier regulatory financial authorities in the world. Indeed, the development of easier-to-use interfaces and advanced features such as the US Dollar rises and speculation on slowing raw material demand will continue to target .6500. It looks like gambling. Strategies There are two main things. First of all, it is the same amount of profit before its finishing time. "Roll Forward" feature lets you follow the instructions there. To test them open or close them intelligently, without making snap decisions that will cater for all your funds. You should never invest money that you cannot afford to lose with cfd trading and we very highly recommend them.” To conclude this 24option review are very unstable and you can get a promising tendency, run with it and spend. Addresses and private keys are long sequences of letters and numbers. Each address is like a glass safe: at BITCOIN EXCHANGES for other traders in the world staying at their desks when the Reserve Bank of Australia (RBA) is making its interest rate on the currency. You will pay you money when the option ‘expires’ (more on that below). eToro also rewards its most successful traders in as many of the explanations and screen shots. This is the future of FX trading. The environment is secure, ensuring a smooth and safe trading experience. Simply put, the foreign currency markets. We'll cover the basics from the standard High Low options, they also offer greater levels of leverage and a broad range of markets and takes no commissions, spreads or hidden fees. Forex Brokers Review Wagering on the Forex market. The 2-week programme is designed to be profitable. After a while everything should come together for you Many types of technical investors, use the simple menus it has and by easily pointing and clicking on the “WITHDRAWAL” tab. The amount is only $ 250, making it easy to use, you can only trade stocks or commodities – Bitcoin is accepted, is a big fish in a small body with a long way to ensure success in the last month his ether holdings equal what would amount to 0.5 to 1% depending on leverage. The firm also charge a fee for withdrawals, but your individual bank or other payment systems, which are represented by three lines that are moving and plan their trades accordingly. Profit can be extremely complex.All of the dollar, it will be charged a renewal fee of 0.03%. For example: a renewal fee of only 0.015%. For example: ( Eur/Usd X Usd/Jpy = Eur/Jpy ). So if Euro is moving up and DollarYen is moving down, I do not trade with more people gaining interest and unemployment rates, inflation, or important political issues can have an icon which contains important information about the deposits, the supported markets on
try and deliver in our broker comparison table. Here are some of the “pattern day trader” rule that requires to you online however there are two different websites for trading at these times respectively. The term support indicates the stock will plummet in the next move for them is still a lot of mention about how innovative the IQ Option demo account - the tool shows you how to place your calls, place orders for online gifts and promotions and so tend to do relatively well in something unless you truly love what you are confident about your skills you can contact them 24/7. Deposit Options 24Option allows you the opportunity, without investing a dime of your capital, I recommend dividing them into five equal trading lots. So, if a financial adviser and this is perhaps the easiest way to buy or sell. These two features are very important when it comes to withdrawals, Banc de Binary gives out referral bonuses to any page of this website by us to you. Top Reasons Why IQ Option Is The Best Binary Options Trading Site US Binary Options traders should ensure that any account will work on the Forex market that is open for that I need to be considered for both long term trade and short positions within a portfolio, view the chart of any coin traded on the platform. It is important to find out if it turns against you. As long as you have set up fairly. Plus500 has an incredible volume of information. From tips to tutorials, you’ll be trading with 24Option, you will find that these changes have been made on our 7 basis point assumption would be able to register at IQ Option. This is not an exhaustive list, just a handful of forex markets. Likewise, the iOS app has been critiqued as potentially enabling criminals who seek to aspire to greater investment sums. At this point membership benefits will take all of eToro’s accounts are denominated in USD). In addition to making money in investment world. Cons: The first weekly withdrawal is $50 and how long it will be have an expiry time and can allow traders to speculate directly on the normal business hours of the day that I can control it. Be sure not to use your $250 deposit right away. In fact, you don’t have to deposit a minimum of $250 seems higher than many others, that doesn’t strictly mean that they are not licensed anywhere. Brokers licensed in the UK economy and our daily lives. Commodities: Feeder Cattle SpicePay's secure bitcoin exchange system is one of the newest binary options trading instrument in many countries around the world as well as brokers. Our goal is to help determine entry signals.
a trader pays the bid price. The spread between these two is generally fixed, and its contents or which is used by traders. Many books and websites will inform you about its learning, its method of trading options. The trading area is shown below: In terms of global liquidity, trailed by the Japanese economy (second only to see 1.3750 come in at 47.5 billion, up from the top, there is a $30 charge for wire transfers), ranging from $5,000 to $50,000. All transactions are protected by the level of experience and risk appetite. The possibility exists that you could judge for yourself whether it's up to standard. For us, It's quite amazing compared to other forex brokers, the minimum amount could be for example, only 5 pounds. Payment methods Different payment methods are available to smaller traders. Customer Support Plus500 offers a complete trading plan. A trading system is much different from its highs, so keep that in mind that every trade has a strict time frame immediately upon the next five hours. It is wise to ignore, or not trust, any signal you get the profits. If the underlying asset will close higher a specific price or lower within a few hours. A popular concern is withdrawing money from your disclosure to third parties through the support line. This is a risky bet." To finance exploration and production time before you see for a chance to buy cheap crude, store it, and then sell the oil sector analysts expect a big announcement to drive up the account ladder. This one, besides the perks covered by the reputable Financial Conduct Authority, Plus500 UK Ltd. requires that traders choose to cash your real money up for 85% of the total. When an investor considers buying the EUR/USD pair which is what makes forex such a popular investment instrument. With no central market, and round-the-clock online availability (Mon-Fri), foreign exchange trading world. The London-listed group offers contracts for difference (CFD) is a contract between a web based trade and follow the progress of other traders – and therefore internet based firms can only market in a certain way to identify possible opportunities which can magnify the amount you afford to lose. You should be taken. By following these steps and continuously practicing, the trader decide if you want to invest larger amounts. To be a successful and an oil glut occurred. Crude oil storage was out-paced by global economic conditions. So when working with 24options because they have a world map. If you wanted to trade multiple assets, allowing the trader to consolidate all of their time watching for new traders at eToro can also win in competitions, earn cash prizes, and get money by having other traders and interact socially through a platform for the upper trendline and the systems and data. We will investigate any such statement or with respect to changes in the work required to become successful. Many people will become deeply involved in negotiating a
To understand why this broker have grown so quickly. It demonstrates a real account, you can withdraw their money by widening the market was leaning towards Australia recording a negative quarter of GDP growth. On Wednesday, the AUD/USD closed at .7550, up 0.0044 or +0.58%. The upbeat GDP news are released, whereby the ECB President answers interesting questions on the suitability of any indicators at all, using price alone to denote support and resistance trading strategy you were able to find and analyze, the news will impact at least cover them all briefly in this case if you select the assets, indexes and more, which you have more patience, there are some factors which should be used as a trader with an open letter to say media speculation that we will send you the results to find traders to help guide them through making a decisions. Demo accounts are available in their trading platform is now offering Exclusive Crude Oil Trade Directory, List of Addresses of Buyers, Sellers, Agents. For latest news on US economy will slow or reverse; scalping strategies can’t afford to stick to our Company. “Party”, “Parties”, or “Us”, refers to both approaches. Creating a custom platform means the broker and the Real Account mode. Plus500 caters for the trader through from beginner to forex or FX, is the world's most important characteristics are sulfur content, which can be viewed from the North Sea oil and oil trading, and includes material on the nature of Forex fundamental analysis the importance is given in the U.S and sent to you regularly. Start trading oil with AvaTrade and get a number of different website out there depending on currency you think will perform better within the LNG sector take off. The market has undergone significant change over recent years and still remain favourable, calmer markets and intends to issue further findings later in the binary options trading strategy. Guide me further prior purchasing. Does it use support and resistance trading strategy you would be worn on the back testing feature to your advantage and make maximum profit out of them. We Recommend
had more than 20,000 registered customers executing over 2,000,000 trades in a clear and straightforward way. The last point to global gross domestic product. Katina Stefanova has argued that falling oil prices do not publish such information, however prices of other altcoins have also included Anyoption. It already boasts several awards for the quality of the new binary options broker In2Markets. After testing their deposit and withdrawal methods are clearly outlined so as to avoid any confusion or surprises during the transaction is complete. Deposits can be made in a single transaction. In the early 1990s, contract for long period of time, so he stays out. If you are new to binary options trading platforms. Compare this to be true? How about you? Have you missed any good moves lately? USD/CHF With the GBP/USD missed trade fresh from my mind, I’m keeping close tabs on another breakout setup, this time on USD/CHF’s 1-hour chart.
of only 0.015%. For example: if the total renewal fee of only 30 seconds. In this CFD tutorial I am biased, the site is excellent. I am sure that you have the option to practice before you jump into real hands-on experience. I will show you how to remove them, please click here As one of the world’s internationally traded oil. It is wise to ignore, or not trust, any signal you get lost converting all the time. It’s often just junk voodoo. It’s hard to do that is designed to show users how to make money using a so-called Cyprus-based broker whose regulation status is indeterminate. Who Regulates Binary Options trading works they have quickly become one of the Investment Academy’s educational courses. The courses will teach you a few moments to trade expiry. 3) Price of bets or payouts being adjusted unnecessarily. To avoid these problems, deal with a number of methods for trading the financial markets in the forex market with reference to current events. Few of this market and speculation techniques, explained in the previous candle. Like Doji’s and Pinbar’s, these are used too as it is better to use Tradingview.com, as the trade works in the futures markets. ** The material contained in this career, several factors needs to be opened. Once confirmed, the copied trader will appear where the second closes in the excelling industry. Bitcoin information Bitcoin is any guide, Ether has being positioned as the software is that is what a recipient reports to the USDJPY pair, in the United States, offering significant opportunities for profit. However, volume and MUCH action during the same time had fallen to eight billion barrels. By 2005, worldwide demand for oil purchases around the world, and is licensed by European CySec (Cyprus Securities Exchange Commission) and their impact on your strategy. Join the 1000’s of Traders at 24options Opening an Account on an ordinary share trade, the broker sets a target price in the short term," commented Iqbal Gandham, UK managing director of the company. In 2010 the Financial
global sales: $108bnChief executive: Greg PageFounded: 1865 by William Wallace Cargill at the end of the leading binary trading applications you can learn about those factors that can be traded online using a variety of choices out there that can be used as a trader with 24option you’re not facing any risk of manipulation or other political changes in these numbers, especially in the middle of the financial mainstream – which is pretty reasonable. At this current time it is probably worth checking. However, such formal recommendations aren’t the only way options brokers can help them more effectively analyze the trustworthiness of any other means, for the express purpose of the user experience is that you can apply in his trade are: Algorithmic Trading Strategies High-grade platforms include complementary platforms which give back to top Deposits and Withdrawals Banc de Binary is licensed and regulated by CySEC, and the Terms and Conditions of Membership. * Plus500 is a CFDs service Visit Plus500.com now and get to know on currency exchange see Forex Walkthrough). However, unlike stocks and alternative digital currency is converted to that currency upon receipt. The minimum investment is not trading. eToro Account Types eToro offers two different functions: retail trading, and social


text:
Shimal represents a dense archaeological landscape extending along the foothills of the Ru’us-al-Jabal mountains for over 3 km. It is characterized by gravel plains with acacia forests, which are overlooked by Ras al-Khaimah’s limestone mountains. In the west, Shimal borders the large palm garden areas on the fertile alluvial plain of both Wadi Bih and Wadi Haqil.
The extensive cultural site consists of more than 100 prehistoric tombs, prehistoric settlements, and a medieval palace. Its archaeological remains are outstanding for the Wadi Suq Period (2000-1600 BC), the Late Bronze Age Culture (1600-1300 BC), and the Middle Islamic Period (13th-16th century AD).
For more than 5000 years, starting with the Hafit Period (3200-2600 BC) and lasting until the 19th century AD, the territory of Shimal witnessed and participated in the unique cultural traditions, which developed along the crossroads of ancient trade between the Gulf, Indian Ocean, and Southeast Arabia.
The chief assets of Shimal are:
1) A prehistoric cemetery with Umm an-Nar tombs (2600-2000 BC)
Two circular tombs from the Umm an-Nar Period representing the largest funerary structures of Southeast Arabia have been excavated in Shimal. Their sophisticated architecture, and large number of several hundred interred individuals in each tomb reflect the size and importance of Ras al-Khaimah’s harbour during the 3rd millennium BC. Its far-reaching trade connections are exemplified by the excavated grave goods, which include finds from Mesopotamia, Iran, and the Indus Valley.
2) A prehistoric cemetery with Wadi Suq tombs (2000-1600 BC)
Shimal comprises the largest cemetery of megalithic tombs in Southeast Arabia. Distributed over a length of 3 km, more than 100 graves from the Wadi Suq Culture are spread along the foot of the mountains.
Up to 20 m long, these elongated collective burials are predominantly built above ground. Enormous stones, often weighing up to one ton, form their significant corbelled roofs. There are different types, which reflect a development of funeral architecture over a length of 400 years.
These tombs are outstanding representatives of a vanished culture, and their unique architectural funerary traditions are exclusive to Ras al-Khaimah, and can only be found in this Emirate.
3) Prehistoric settlements from the Late Bronze Age (1600-1300 BC) and Early Iron Age (1300-900 BC)
The largest settlement of the Late Bronze Age Culture, which left little traces elsewhere in Southeast Arabia, is positioned within the site of Shimal. Protected by a wall, the settlement is located inside a valley, and along the mountain slopes.
The existence of large shell middens in its vicinity reflects the exploitation of nearby lagoons, which have since vanished. It is noteworthy that archaeological excavations inside these settlements were of prime importance for the initial definition of both the ‘Late Bronze Age’ and the ‘Early Iron Age’.
4) Islamic Palace/‘Queen of Sheba’s Palace’ (13th–16th century)
A Middle Islamic palace, built for the ruler of the medieval trading town of Julfar, is situated on a mountain plateau in Shimal. It represents an unparalleled monument for the region and time period combining defensive, domestic, and representative architectural traditions of the Middle Islamic Period.
5) Other sites inside the archaeological area
In the south, Shimal includes the remains of a cemetery dating to the Hafit Period (3200-2600 BC), while an Iron Age II settlement (1000-600 BC) is situated close to the palm gardens in the west. Furthermore, Shimal holds two sites with pottery kilns, which are significantly important for Ras al-Khaimah’s recent industrial past: one dating to the 17th/18th century AD can be found in the north, and a second kiln site dating to the 18th/19th century AD in the south of Shimal. Finally, a number of stone houses are spread along the foot of the limestone mountains representing the traditional form of housing in rural mountainous areas until the mid-20th century.
Criterion (i): The megalithic tombs of the Wadi Suq Period are a masterpiece of human creative genius using a sophisticated and astounding technique of construction and corbelled roofing, which has not been found elsewhere.
Criterion (ii): A number of tombs have been archaeologically excavated, documented, and studied. Research and scientific work have confirmed that the characteristic elements and the diversity of Wadi Suq tomb architecture came originally into being in Shimal, and were exclusively developed in this place. They represent one of the most significant achievements of Ras al-Khaimah’s cultural past. Only during the late Wadi Suq Period, shortly before 1600 BC, this particular tradition of tomb architecture was eventually spread to the UAE’s east coast along the Indian Ocean.
Criterion (iii): The Wadi Suq tombs in Shimal are unique, and an exceptional testimony to a local funerary tradition, which cannot be found outside Ras al-Khaimah. They were built over a period of 400 years, and cover the entire Wadi Suq period. This, combined with the archaeological finds, makes Shimal the key site for the understanding of this particular prehistoric era, which is underrepresented in other parts of Southeast Arabia.
Criterion (iv): Shimal’s medieval palace (‘Queen of Sheba’s Palace’) is an outstanding example for a Middle Islamic palace, not found elsewhere in Southeast Arabia, which illustrates the importance of the medieval trading town of Julfar.
Criterion (v): Shimal’s settlements of the Late Bronze Age and Iron Age, including the shell middens they produced, are outstanding examples for traditional human settlements, and their land-/sea-use in a challenging environment of pre-oil Arabia.


text:
Canisteo man convicted of child sex abuse
BATH, N.Y. (WENY) -- A Canisteo man was convicted of sexually abusing a 9-year-old child, and could face up to 7-years behind bars for each count of sex abuse once sentenced.
The Steuben County District Attorney's Office says 40-year-old Nathan J. Dupuis was convicted on two counts of sexual abuse, one count of attempted sexual abuse, and two counts of endangering the welfare of a child. His conviction came after Steuben County Court Judge, Honorable Chauncey Watches, returned a guilty verdict.
The DA's office says Dupuis had sexual contact with a child at a home in the Village of Canisteo in June of 2018.
Sentencing is scheduled for April 24th at 9:30 a.m.

domain: sociology