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This was the most intense moment of my breathing life, enjoy
Normally when I consume shrooms it's by myself in the dark of night. This is to avoid distractions and confrontation, the two things that royally screwed me. I was camping with a friend and his hippy-esque family with whom I've grown the mushies with for years. It was a beach, so we decided to eat about 4 grams each of dried Cubensis an hour or so before sundown. Unfortunately, my buddy got paranoid as hell sitting on an open beach with everyone walking by, so we went back to the sight and chilled out in the tent, now basically immobile. It was a bit hot so I just lay still and listened to the people talking outside of the tent. Here's where it gets good.
For a while they just sat around and joked with each other, which I found hilarious. Observing the way humans get along happily just made me feel glad and cheerful. Then they started to cook dinner and it all went to hell. They talked about chopping up hamburger, and my tripping insane mind translated that into "chopping each other up". So I lay in the tent in utter horror as I heard the two oldest laugh and the others scream, then came the chopping. Of course it was firewood, but the context in which it came was horrible. I'd hear whacks and screams over and over again. At this point I ought to mention that I'm STILL not a hundred percent sure they weren't fucking with me, but that possibility is microscopic, as my buddy didn't hear a thing, and he's a bad liar so I would have known. The events outside then resembled cooking a young girl alive, with her shrieking in agony. I snapped.
I did a sort of commando dive out of the tent door, fearing one of them would be standing there with the hatchet waiting to decapitate poor me. With eyes wide and terrified, and adrenaline pounding hard through my entire being, I made one glance to decide if it was possible to save the girl or just to run like a jackal. Nothing. There they sat, all of them, calmly eating hamburgers in lawn chairs around the fire. I had been SO sure of what I had thought I was hearing that this sight basically stunned me. I awkwardly turned and sort of speed walked away towards the bathroom to try and figure out what the hell was going on. One of them followed, which sure as hell didn't comfort me(thought I was being pursued). The woman who had come was a nice lady who lived through the 60's and knew what to do. She stayed completely calm and offered to take me back to talk. Unfortunately, I'm not exactly a normal person.
By this point my loaded brain was working double time to make sense of this troubling and mind blowing situation. It had decided that I was being tested. Didn't know who by or for what, but I decided that the point of the test was to resist this woman(who I thought had been planting the fake voices into my mind). I told her I'd follow, so she started back, but instead of heeling I turned head tail and jogged(honestly) over to a campsite with a bunch of rednecks, stammering and stuttering that "them folks over yonder be crazy!" The head honcho came up to me and said something like "lookey what we got here!" and something in my broke. All the pain and confusion went away and I think I lost my will. The reason was that my mind had decided that EVERYONE in the campsite was in on this whole charade. Luckily the woman had caught up and she led my back to the sight, telling the rubberneckers I was drunk. On the walk by my mind made another leap: that everyone in my ENTIRE life was in on it. Sort of a Truman show scenario. Anyways I believed then that my whole life had built up and prepared me for this moment, which is where this story gets out of hand. I doubt any words I say could truley convey how this went down or what it was like, but here goes:
"It is pitch black. These angels or demons that have captured me now make me sit in a chair before a dead fire. However it is not dead, there are embers. Embers glowing and bright as the hottest of fires. Could it be hell that sits before me now? Yes. That must be it. This is my final judgement, right here and now. All of life has been a lure, all of it fake and artificial. The devil has tempted me with all earthly pleasure, and now I must renounce it all or face the eternity of hellfire before me! What is this? the woman is talking to me... of course! Woman! The creature of the devil is a female, she is like a cat and will try and trick me into the fires! I must be wary and resist her at all cost! For the choice I make right now is the purpose of all life. CHOICE is the meaning behind all things! When we die the choice we go with will transform us either into pure energy of love or energy of hate! I shall not fail! Not now! NEVER!"
With the aforementioned mentality in mind, and my mind once again blazing, I forgot to notice something. It had gotten incredibly cold, and apparently I was shivering and had a crazy heart beat. Of course I didn't feel the cold, I couldn't feel anything physical at that point, having declared unto mine self that the body is a cage and I must let go of it. It was then that "my captors" thought it best to DRAG me into a tent before I freeze to death. There was no way I was gonna let them do that. I struggled like a man with nothing left to lose. The fight seemed to last forever, as 2 teenage boys and an adult woman dragged me inch by inch towards my doom. I felt stronger than I had in my life. The endurance of my will would NOT be bested. So powerful was my desire for life that at one point I hooked my bare foot on the hot fireplace to get a grip. The feeling of being burned did nothing but enrage my passion to defeat this devil, this serpent of death. Eventually they got me into the tent, though I then thought that it wasn't the actual physical fight that need be won, it was just a matter of will. I would not lose this fight.
In the tent was an air mattress with several blankets on it. When I touched it I felt the most comfortable sensation imaginable, It was soft and warm and seemed to beacon for me. Of course I knew then that it was the final effort of satan to deceive me. For, you see, the woman had stayed near to keep me from running off, and she actually tried to get me to lay down by hugging me. Finally losing footing and dragged down by her I sank into the mesh. More horror. Lying still on the bed my surrounding morphed into the sands of Egypt, endless waves of earth. I looked at my hand and nearly screamed as I saw it becoming part of the sand. Melting into the ground and becoming one with the endless lands. By now I was weeping, remembering all in life I had loved and hated, the memories came a million a second. I mustn't surrender. To keep from losing myself to slumber or soft comfort I keep both legs sticking out in the cold.
Hours later I awoke after having passed out. It was still dark but early morning. I was freezing like ice, but still believed that what had happened the night before would go on. I snuck out of the tent and went down to the beach, which was abandoned. I sat there freezing for nearly 45 minutes until the sun started to rise. It was more confusing than anything. Had I won? Was my soul free? Finally I got up and went back to the site, where a few people were up. We said nothing and I sat like a stone where I had last night and drank some coffee. Once everyone was up we sat around the fire awkwardly, as I didn't know whether to trust them or steal a car and get the hell out of their torture chamber. Eventually I got fed up with the confusion and went ahead to ask what had gone down the day before. Then came their story, which I have woven into my own account to make sense of it, as at the time I had NO idea what was really happening.
We had a few more days of camping left, and after evaluating everyone to be "normal" I came to two conclusions about the whole experience, which I hold true today. 1) It was the shrooms, and a couple wacked out coincidences. They made me hallucinate the voices, and things just went from there. However, the seeming perfection of how it all happened still confuses me. If this was the case, then I thought it was well worth it. No one had been hurt(except for my burned and blistering big toe), and I gained an immense appreciation for life, after having fought fiercely for it. 2) The people of the campsite had been possessed by some force and really had been testing me, under the guise of mushrooms, and simply planted memories into the people involved excluding me. It doesn't really matter either way as I gained the same thing no matter which way you view it: gratefulness. I had been feeling pretty glum at the time, basically thinking like a nihilist constantly, not caring about anything. I feel as if this trip happened for a reason, to teach. So it did, and so I learned.


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text: Mantua has a reputation for being a great destination of art lovers. The dialect of the citizens of Mantua is considered harsh by other Italians. The mood is considered somber befitting a place that is muggy in the summer, and foggy in the winter that made it appropriate for the setting of the Verdi's opera Rigoletto. Not just a museum piece, and a vibrant city, Mantua hosts, since 1996, an international festival of literature every year in September. There is also a jazz festival each July.

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Another one bites the dust, after 5 years of marriage actor Tom Cruise and actress Katie Holmes have decided to divorce. Katie’s attorney released a statement:
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domain: psychology


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text:
Dr. Jason R. Jolley is an associate professor of Spanish at Missouri State University in Springfield. He teaches courses on all aspects of the Spanish language, as well as in the areas of literature and translation. His research interests include the use of genealogical rhetoric in Latin American literature and the application of technologies to language learning.
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domain: literature


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When I learned that the From Left to Write Book Club was reading Cleopatra: A Life, I realized that I could picture Cleopatra in my mind. She looks exactly like Elizabeth Taylor. Apparently, I’m not the only one. The first page of Cleopatra by Stacy Schiff mentions that, among other things, Cleopatra is “a synonym for Elizabeth Taylor.” Liz makes an appearance again on page 2:
The Ptolemies were in fact Macedonian Greek, which makes Cleopatra approximately as Egyptian as Elizabeth Taylor.
We watched several Elizabeth Taylor movies after her death in March. My favorite was a sentimental choice from a memory of watching National Velvet with my family when it was shown on television sometime in the 70s. I also recommend The Sandpiper with some reservation. The storyline is unconvincing, but the cinematography and Taylor’s presence in that setting are stunning. The Sandpiper also has a haunting score that includes the 1965 Academy Award winner for Best Original Song, “The Shadow Of Your Smile.”
We did not watch Cleopatra this spring, so I requested that movie. Since the run on Elizabeth Taylor movies is over, I received it in time to watch it over the weekend, at the same time I was reading the book. I also requested another movie version of Cleopatra, the 1934 film that was directed by Cecil B. DeMille and stars Claudette Colbert. It was a Cleopatra weekend!
We watched the older movie first. The best parts were the scantily-clad women and suggestive dances from a time before the Production Code was rigidly enforced. We also got a kick out of laughing at the obviousness of the dialogue and plot in certain places, although it’s hard to judge old movies on that. Maybe what seems obvious now was cutting edge when Cecil B. DeMille did it.
We preferred the 1963 film. There were still scantily-clad women, the dialogue was more believable, and the story more cohesive. It probably helped that it was a four hour movie (we watched it over two nights). I liked the soundtrack in the older movie — it was more evocative. The ’63 soundtrack sounded like a sixties movie soundtrack. I was surprised how often this Cleopatra pulled me out of the ancient world and into sixties Hollywood with an anachronistic fabric, a jarring philosophical speech, or modern choreography. Still, over all it worked as the epic film it was meant to be.
I haven’t finished the book Cleopatra by Stacy Schiff, yet, but I’m very much looking forward to finding out what the films got right and wrong in the story of this powerful woman.
In Cleopatra: A Life, Stacy Schiff digs into the history books to share with us who the true Cleopatra was. As a member of From Left to Write book club, I received a copy of this book for review. You can read other members posts inspired by Cleopatra: A Life on book club day, September 27 at From Left to Write.


The number of moles of hydrogen will be determined indirectly. Hydrogen gas is flammable the boiling step is to be completed by all students before continuing with the reaction.
Guidelines for Laboratory Reports Purpose: If spilled, rinse the area immediately with copious amounts of water. Convert this value to atm for your calculation of R. You will make an experimental determination of the number of moles of hydrogen molecules produced and the volume occupied by these molecules.
Measure the length in millimeters. The number of moles of gas can be obtained from the stoichiometry of the reaction. Wrap the piece of magnesium around the copper loop so that it will fit easily into the gas-measuring tube.
Try to avoid mixing the acid and water as much as possible. Heat mL of tap water to boiling to remove dissolved air. The collected data number of moles and volume at STP will be used to calculate the molar volume of the hydrogen gas. Add about mL of water to a mL beaker.
Handle this acid with care. Weigh a sample of metal ribbon accurately on the analytical balance. To account for the solution pushing on the gas, the height of the water in the collection tube must be measured and converted to mmHg. The volume of gas is calculated by water displacement in a graduated tube.
Insert the one-hole rubber stopper firmly into the tube as shown in Figure See the discussion of water vapor in chapter 5 of the lecture text. R is the "gas constant. Remove the rubber stopper with copper metal loop from the tube. Substitution of these quantities into the Ideal Gas Law allows calculation of the gas law constant, R.
The basis of this experiment is the following reaction in which you will react a known mass of Magnesium with excess hydrochloric acid to produce the substances shown: Do NOT place the hot beaker directly on the cold bench top. A typical reaction is given below: The pressure must be corrected for the presence of water in the collected gas.
Trim the ribbon until the mass falls within the ranges below: Tilt the gas-measuring tube slightly. There are to be no open flames while hydrogen is being generated. When the water boils, cover the beaker with a watch glass, remove from the heat and allow it to cool to room temperature.
Place your finger over the hole in the rubber stopper and invert the gas-measuring tube. If the volume, temperature and pressure of the gas sample are then measured, the gas constant can be obtained by appropriate rearrangement of the Ideal Gas Law.
The volume of hydrogen gas produced will be measured directly on the scale of a gas-measuring tube. The gas laws of Boyle and Charles will be used to correct this volume, measured under laboratory conditions, to the volume the sample of gas would occupy at STP.
Concentrated hydrochloric acid can burn skin and damage clothing. Be sure to ware your safety goggles at all times during this experiment. Divide the density of mercury Let the apparatus stand about five minutes after the magnesium has completely reacted.
Using beaker, Slowlyfill the gas-measuring tube with water. The number of moles of gas is determined from the stoichiometry of the chemical reaction of the metal with hydrochloric acid. Then divide the length of the water column remaining in the tube by the relative density to obtain the pressure on mmHg.
Lower the stoppered end of the tube into the beaker of water. The gas law constant, R, will be evaluated using a reaction between hydrochloric acid and a metal to produce hydrogen gas.
This experiment should aid in the understanding of the mole concept and the concept of molar volume of a gas. The ideal gas law states:The ideal gas law states: pV = nRT, where p is the pressure, V is the volume, n is the number of moles of gas present and T is the absolute temperature of the gas.
R is the "gas constant.". In this experiment, we will use the reaction of a metal with hydrochloric acid to produce a known number of moles of hydrogen gas.
EXPERIMENT 9C DETERMINATION OF THE IDEAL GAS CONSTANT, R I. Problem: M~sure. The ideal gas constant R can be found experimentally by determining the number of moles of a questions based on the following data.
A midshipman running this experiment found that. 6—Evaluation of the Gas Law Constant. Name: _____ Date: _____ The accepted value for the gas constant R is L·atm/mol·K.
In this experiment, hydrogen gas will be collected in a calibrated tube called a eudiometer. By measuring the.
Determining the Gas Constant “R” PRE-LAB DISCUSSION The basis of this experiment is the following reaction in which you will react a known mass of Magnesium with excess hydrochloric acid to produce the substances shown: Mg + 2 HCl!
MgCl2!+ H2. Show transcribed image text Pre-lab Evaluation of the Gas Name 4 Law Constant 1. What gas will be generated in this experiment? What gas will be generated in this experiment. Page 1 of 4 Experimental Determination of the Gas Constant Objectives The objectives of this lab are to experimentally determine the value of the Gas Constant, R, and to practice using the Gas Laws to solve a variety of problems.Download


When there’s no story, there’s no news. In fact, journalists were getting bored through the evening and some even packed up their gear and left West Florissant. Other than a fight between a couple of young men in front of The Burger Bar, it was a rather uneventful evening. It was really a nice change of pace compared to the chaos that has been going on for the last week and a half. There were reports on the police scanner of shots being fired throughout the evening, however none of them seemed to be related to the current situation. Protesters seemed to be in sync with local law enforcement.
Although the protests show no sign of stopping any time soon, throughout the evening, there were protesters peacefully assembling on W. Florissant in Ferguson, Missouri. Volunteers handed out water to the protesters and the journalists on the scene. There were even some activists who set up a voter registration table so protesters could make their voices heard in elections as well as on the street. Captain Johnson of the Ferguson Police was seen throughout the evening trying to bridge the gap with protesters.
One protester interviewed said, “We’re out here because we’re hurt…and no one has said we’re sorry for your loss.”
Another protester overheard talking to someone is quoted as saying “We tore it up together, let’s clean it up together.”
Other protesters were marching with signs chanting things like “Hands up, don’t shoot. We will protest, cause we don’t loot!” and “One Voice! Mike Brown! What do we want? Justice! When do we want it? Now!”. There was also a new chant we hadn’t heard before: “No justice, no peace. No racist police.”
A large group of about 100 protesters arrived early in the evening at the Ferguson Police Department, but there was no incident.
Some of the protesters even stopped marching long enough to take photos with one another, continuing on chanting “We young, we strong, we marching all night long.”
Then along comes the “Peace Train”. The police did not allow the owner to drive it around the streets because it was not street legal, however, he would drive it through the local parking lots playing Marvin Gaye, helping to keep protesters calm during the evening.
By 11:00PM (CST) things were still quiet and people were still peacefully marching and cooperating with local police. Some people were even going home without incident.
Police seemed to be as laid back as the protesters were this evening as much improved police tactics were used tonight in Ferguson. That is until, out of nowhere, the police formed a line and started randomly clearing parking lots and telling protesters to return to the sidewalks and pushing people INTO the streets. Protesters did fall back, with one saying “It’s a trap! They are trying to get us to retaliate.”
A member of Peace Keepers told protesters, “Let’s not give the press entertainment tonight.”
Needless to say, tensions started getting high when police took action without warning or reason, but things quickly got calm again as a man walked down the police line shaking their hands.
Trying to end the protest in prayer, protesters started gathering in the parking lot of Sam’s Meat Market, led by ministers of The Church of God and The Church of Christ.
At 11:30PM (CST) the march officially ended and a call made for protestors to be at the Justice Center in Clayton at Bob McCollough’s office tomorrow at 9:00AM (CST).
The police stood and didn’t move while people circulated in the crowds saying, “It’s time to go.”
Protesters were clearing out for about 20 minutes. Then, a water bottle was thrown…
Police ran into the crowd as people scattered, ordering everyone to the sidewalks. Another water bottle was thrown…police restrained themselves, but it was nearing chaos.
Someone in the crowd yelled, “They just stole my phone!” and protesters and police took off after the thief.
Due to the incident prior to that, SWAT arrived on the scene and yet another water bottle was thrown. This time, SWAT got involved, “If you are in the middle of the street, you are unlawfully assembled and may be subject to arrest.”
Two police officers chasing a protester, were able to stop him in the street and arrest him. While arresting him, once again, a water bottle was thrown (next up on the Government’s Agenda: Ban Assault Water Bottles) and a live shot was heard being fired at officers.
Media was immediately commanded by SWAT to return to the designated media staging area. Some of the protesters formed a line – hand in hand – between the police and the crowd attempting to ease tensions, all the while telling the protesters “Don’t feed the media”. Flared tensions were eased a bit, but police still formed a 3 block long line in the middle of W. Florissant.
The police then told media to evacuate the area and return to the media staging area at the Command Post for their own safety, when they had to pull people from the press area that were not credentialed press.
Sharon Warren of Ferguson, said about the incident, “I wish this whole thing had never happened.”
Peaceful protesters were screaming at the media to go home, thinking that the agitators were doing this for the cameras.
10 people were arrested, including one member of the National Lawyers Guild of Legal Observers, while protesters chanted “Who do you serve? Who do you protect?”
Despite lots of commotion, officers did not deployed gas tonight.
The entire protest area was cleared. People were being told they could sit in a designated parking lot all night, there was a floodlight lighting up the parking lot for their safety.
W. Florissant is open for local vehicle traffic again. Police are checking ID’s for a Ferguson home address at Lucas & Hunt, and at Ferguson Ave.


text:
Double delight for Wisbech community manager
published on 23 Feb 2023
The Salvation Army community manager in Wisbech said she is delighted having won two prestigious community awards in the town.
Kristyna Mansfield was nominated for the Wisbech Community Hero and Judges’ Award at Wisbech Town Council’s Unsung Heroes Awards and took home both prizes. After she was supported by The Salvation Army back in 2016, she began volunteering and went on to lead the toddler group before taking up her current role.
The church and charity works across the town from providing hot meals to vulnerable people and running lunch clubs and baby groups. A section of the church and community centre at John Thompson Road has been recently adapted to provide washing facilities while washing machines are also available while Employment Plus, a service to help people become job-ready, is available regularly.
Kristyna and her team also cooked over 70 Christmas Day meals last year and handed out hampers to 178 families.
Kristyna, who took over the role six months ago, hailed the efforts of all at The Salvation Army.
She said: “It’s amazing considering the short amount of time I’ve been doing the job. It’s not been easy. We’ve excelled at the community side of our work, which is thriving. Our toddler group runs for two days a week, every seat is taken at our Over 60s luncheon club and we run an outreach service three nights a week offering rough sleepers and vulnerable people hot food and support.
“We also try to signpost people to other organisations for further support and also offer showers and washing facilities.”
Kristyna praised the partnership working in Wisbech and said the awards were testament to how effectively the different organisations worked together.
She explained: “We work with the local authorities and police and we are all trying to get to the same result – helping to support our community. We’re all passionate about helping people and what we have achieved shows anything is possible and anyone can do it. I wanted to thank everybody for their continued support. My job isn’t a job – it’s a blessing and a calling.”
For more information on The Salvation Army in Wisbech, search The Salvation Army Wisbech on Facebook or call 01945 461 416.

domain: news


text:
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Pure NV products are created by professional hairdressers and are used in the top hair and beauty salons across the country. This product is safe for all hair types, including hair that has been treated with relaxers and straighteners, perms and waves, and any hair color brand or Keratin Smoothing System. All of our salon quality products are enriched with the purest Keratin and/or Collagen and are free of harmful ingredients like Sodium Chloride, Sulfate and Parabens, ensuring that they are of the highest quality for hair care products on the market. They are color safe, and compatible with all texture management systems. Always Animal Cruelty Free, Made in the U.S.A and 100% recyclable. Your satisfaction is our guarantee!

domain: chemistry


text:
Stubbornly low US inflation and a shaky economic outlook justify an interest rate cut by the Federal Reserve, the head of the central bank's St Louis branch said Friday, explaining why he opposed the decision to hold rates steady.
Federal Reserve Board Chairman Jerome Powell speaks at a news conference after a Federal Open Market Committee meeting in Washington, DC, on June 19, 2019. (Photo: AFP)
The Fed opened the door to a rate cut Wednesday amid rising concerns about the economy due to trade frictions, but voted 9-1 to keep the main lending fee steady in a range of 2.25-2.5 percent.
The one dissenting voter, James Bullard -- the first in 18 months to oppose a Fed policy decision -- said "US economic growth is expected to slow" and "uncertainties about this outlook have recently increased."
He rejected the argument made consistently by the central bank's leadership that temporary factors are largely to blame for keeping inflation well below the Fed's two percent target for many months.
Lowering the benchmark rate "would provide insurance against further declines in expected inflation and a slowing economy subject to elevated downside risks," said Bullard, a voting member on the Fed's policy-setting Federal Open Market Committee.
Even if the world's largest economy does not slow, "a rate cut would help promote a more rapid return of inflation and inflation expectations to target."
The last time there were dissenting votes against a policy decision was in December 2017 when two officials objected to a rate increase, one of nine in the past five years.
Fed Chairman Jerome Powell and other central bankers have been saying since the start of this year that they expected the economy to pick up the pace and would be "patient" before making any moves.
However, President Donald Trump's aggressive trade attacks, especially on China, have sapped business confidence amid growing concerns about the health of the global economy.
The Fed vowed Wednesday to take appropriate action to maintain growth.


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–by Dr. Jeff Whitworth
Three cornered alfalfa hoppers (TCAH) (see adult, fig 1.)
Figure 1 Three Cornered Alfalfa Hopper Adult (Ed Beeson)
are causing concern in southeast Kansas soybean fields. TCAH’s have been reported from Kansas in prior years but not many and most often from alfalfa fields. As the name implies, they will feed from the phloem in alfalfa/sweet clover/peanuts/etc. and usually do not reach population levels that would cause economic losses-more just a novelty in Kansas, so far. However, in parts of the south and southeastern U.S. they can reach densities that may require treatment, especially in soybeans. Both nymphs (see nymph fig 2)
Figure 2 Three Cornered Alfalfa Hopper Nymph (Ed Beeson)
and adults may suck the juice from the plant’s phloem in such a pattern as to cause the stem to actually break (see fig 3.) at the point of this feeding and thus the plant my lodge. However, in Kansas, this remains a rare occurrence but one that should continue to be monitored.
Figure 3 Soybean stem (Ed Beeson)

domain: biology


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An overview of the first 5 years of the ENIGMA obsessive-compulsive disorder working group: The power of worldwide collaboration.
van den Heuvel OA., Boedhoe PSW., Bertolin S., Bruin WB., Francks C., Ivanov I., Jahanshad N., Kong X-Z., Kwon JS., O'Neill J., Paus T., Patel Y., Piras F., Schmaal L., Soriano-Mas C., Spalletta G., van Wingen GA., Yun J-Y., Vriend C., Simpson HB., van Rooij D., Hoexter MQ., Hoogman M., Buitelaar JK., Arnold P., Beucke JC., Benedetti F., Bollettini I., Bose A., Brennan BP., De Nadai AS., Fitzgerald K., Gruner P., Grünblatt E., Hirano Y., Huyser C., James A., Koch K., Kvale G., Lazaro L., Lochner C., Marsh R., Mataix-Cols D., Morgado P., Nakamae T., Nakao T., Narayanaswamy JC., Nurmi E., Pittenger C., Reddy YCJ., Sato JR., Soreni N., Stewart SE., Taylor SF., Tolin D., Thomopoulos SI., Veltman DJ., Venkatasubramanian G., Walitza S., Wang Z., Thompson PM., Stein DJ., ENIGMA-OCD working group None.
Neuroimaging has played an important part in advancing our understanding of the neurobiology of obsessive-compulsive disorder (OCD). At the same time, neuroimaging studies of OCD have had notable limitations, including reliance on relatively small samples. International collaborative efforts to increase statistical power by combining samples from across sites have been bolstered by the ENIGMA consortium; this provides specific technical expertise for conducting multi-site analyses, as well as access to a collaborative community of neuroimaging scientists. In this article, we outline the background to, development of, and initial findings from ENIGMA's OCD working group, which currently consists of 47 samples from 34 institutes in 15 countries on 5 continents, with a total sample of 2,323 OCD patients and 2,325 healthy controls. Initial work has focused on studies of cortical thickness and subcortical volumes, structural connectivity, and brain lateralization in children, adolescents and adults with OCD, also including the study on the commonalities and distinctions across different neurodevelopment disorders. Additional work is ongoing, employing machine learning techniques. Findings to date have contributed to the development of neurobiological models of OCD, have provided an important model of global scientific collaboration, and have had a number of clinical implications. Importantly, our work has shed new light on questions about whether structural and functional alterations found in OCD reflect neurodevelopmental changes, effects of the disease process, or medication impacts. We conclude with a summary of ongoing work by ENIGMA-OCD, and a consideration of future directions for neuroimaging research on OCD within and beyond ENIGMA.


Front-end IC features zero offset
austriamicrosystems (SIX: AMS), a leading designer and manufacturer of high-performance analog ICs, today announced the AS8510, a high precision data acquisition front-end IC for automotive battery current, voltage, and temperature sense applications, and general sensor interface applications where precise measurement of small signals close to ground is required.
The new flexible sensor interface IC offers advantages over alternative solutions, including being the first to feature a 16-bit dual-channel ADC + PGA architecture with less than one LSB of offset and noise. Highly configurable, the AS8510 allows systems tailored to individual needs making it well suited for a wide range of present and future battery management applications The AS8510 in combination with austriamicrosystems System Basis Chip and a microcontroller provides an entire battery sensor semiconductor solution for both high-side and low-side at a price below $2.80 in volume.
The AS8510 data acquisition front-end IC features two independent analog input channels with 16-bit ADCs, each with individually programmable sampling rates. Each channel has a low-drift programmable gain amplifier for handling +/- 160 mV signals or 0 V to 1 V when by-passing the PGA, thus battery currents from the mA range to the kA range can be measured from a 100 ?? shunt. A highly linear sigma delta architecture and wide range of sampling rates allows the AS8510 to provide flexible support of electric vehicle applications. The offset auto-zero feature (both channels) allows high accuracy measurements with low value shunt resistance with negligible insertion loss. Also, various operating modes include low power standby with current monitoring for active wake-up.
“The need for increasingly more accurate and efficient power management is being driven by the exploding market for battery powered devices and, increasingly, electric vehicles,” stated Manfred Brandl, Product Manager Automotive Sensor Interface and SBC ASSPs. He continued, “With the AS8510, designers have the highest accuracy available and the flexibility required for a wide variety of applications. In addition, by adding an austriamicrosystems LIN companion IC and a low-cost microcontroller, automotive designers can realize reduced time to market in an evolving field at competitive price and improved performance.”
The AS8510 operates with a current shunt sensor in a 12 V system either at a battery’s ground terminal or at the plus terminal in conjunction with a dedicated level shift companion IC, or it can be used as a general purpose sensor interface for precise measurement of signals close to ground. Fully differential inputs allow the AS8510 to capture differential signals with 300 mV of common mode above ground and 160 mV below ground. The 2-channel architecture enables digital error correction techniques like “delta by sigma” division or capture of bridge currents / voltages with subsequent error correction in an external microcontroller. In addition, the AS8510 draws just 40 µA in standby mode.
The AS8510 high precision data acquisition device can be configured for differential simultaneous 2-channel operation, or for multiplexing 2 single-ended channels in addition to one of the differential channels for sequential measurements. In addition to measuring voltage and current, the AS8510 also allows accurate temperature measurement from either the internal sensor or from an external temperature sensor, which may be powered by an on-chip 250 µA current source. The AS8510 includes an internal precision reference, integrated digital low-pass filters, on-chip precision oscillators and a 4-wire SPI interface.
The AS8510 is available in a SSOP20 package, operates from 3.3 V, and has an ambient operating temperature range of -40 to +125°C.
Price & Availability
The AS8510 costs less than $1.40 in high volume. Samples are available on request.
An adapter board for quick start with the AS8510 is available. An evaluation system for voltage, temperature and battery current measurement at 12 V plus terminal is available. Contact austriamicrosystems for price. For further information on the AS8510 or to request samples, please visit www.austriamicrosystems.com/Battery_Mgmt/AS8510.


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CHICAGO -- You know him as the hot shot hollywood agent, Ari Gold, on "Entourage" that won him three straight Emmy Awards.
Or as Mr. Selfridge in the British drama.
But Jeremy insists that he is a normal guy with a humble upbringing.
Jeremy joined WGN Morning News Wednesday morning to talk about the start of his career and his passion for music.
The Evanston native got his acting start at the famous Piven Theatre Workshop, run by his parents. The anniversary gala he is planning will honor his legendary mother, Joyce Piven.
Along the way, Jeremy developed another passion for music and eventually became a drummer in his own band, Bad Decisions.
Piven Theatre celebrates 45 years with "Once Upon A Stage" Anniversary Gala Saturday, May 6. For tickets, visit piventheatre.org or call 847.866.8049.


A great video of the US Air Force F-35 Aircraft that has a reputation of making people jellous in the YouTube comments section. The F-35A fighter pilots, assigned to the 33rd Fighter Wing at Eglin Air Force Base, Florida, arrived to perform fourth and fifth generation integration fighter training with F-16 pilots assigned to the 169th Fighter Wing.
“Integration tactics for the F-16 and F-35 are still being developed, so regular joint training as well as access to our electronic ranges is mutually beneficial,” said Lt. Col. Michael Ferarrio, a 17-year fighter pilot and program manager for the 169th FW. “As leaders of the SEAD (Suppression of Enemy Air Defenses) community, the SCANG has a very high interest in helping develop tactics with our newest SEAD asset, the F-35.”
The term, generation, refers to an aircraft in relation to the design of its airframe. When the construction of the frame is changed on an aircraft, it signifies the beginning of a new generation. The Air Force’s fourth generation aircraft include the F-15 Eagle and Strike Eagle and F-16 Fighting Falcon fighter jets and fifth generation aircraft include the F-22 Raptor and the F-35A Lightning II.
In the future, the F-16 and F-35 will work together to provide SEAD and DEAD (Destruction of Enemy Air Defenses) for the Combat Air Forces. Joint training is critical to ensure that combatant commanders get assets and pilots that are ready to operate together at a moment’s notice.
“The benefit here at McEntire is that we have the greatest depth of experience in the SEAD/DEAD mission here between the pilots and the maintainers,” said Ferrario. “The biggest benefit to the Air Force as a whole is to be able to transfer that experience to the latest airframe.”
This wasn’t the first time working with the F-35A for one crew chief here. Tech. Sgt. Lee Kassay, assigned to the 169th Aircraft Maintenance Squadron, had the opportunity to work with this aircraft on a recent temporary deployment.
“Their pilots were very impressed that we knew something about the F-35,” said Kassay. “All of the crew chiefs here are very knowledgeable, so it is easy to teach them and they are willing to learn.”
McEntire JNGB is looking forward to the future and is posturing for the potential of receiving the F-35. Upgrades to facilities, along with runway and taxiway improvements have been accomplished that would make the transition from F-16s to F-35s a simple process. The 169 FW is poised to receive the latest in advanced fighter technology, the F-35 Lightning II.
Video Description Credit: Senior Airman Ashleigh Pavelek
Video Credit: Sgt. Travis Gershaneck and Pfc. George Melendez, Dane Wiedmann, Cpl. Travis Gershaneck, Lance Cpl. Courtney Kueker, Cpl. Isaac Lamberth, Lance Cpl. Maxwell Pennington and Master Sgt. Steven Williams
Thumbnail Credit: Samuel King Modified by ArmedForcesUpdate


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In their golden years, nearly all retirees have suffered from discomfort of some kind. In this case, medical marijuana can be of assistance. An intriguing aspect of medical marijuana’s applications is that it isn’t always necessary to eat the plant itself.
Using Medical Cannabis for Senior Health Care
To alleviate both acute and chronic pain, medical marijuana can be ingested, or used topically to target the body’s preexisting cannabinoid receptors. Pain from arthritis and other arthritic conditions, as well as nerve damage and chronic conditions including multiple sclerosis, Parkinson’s disease, and glaucoma, can be alleviated.
One of the fastest-growing demographics of cannabis consumers in Australia are those 65 and older. Medical marijuana is legal in Australia. Because of this, there is fear among some professionals that elderly people would attempt to address their own medical issues without proper direction.
Methods of Medical Marijuana’s Effectiveness
With medicinal marijuana, the objective is to determine the therapeutic amount that provides benefit without inducing a high, impairing response speed, or inducing sleepiness. Finding the optimal dosage requires a gradual increase from a modest starting point.
Cost of Medical Marijuana.
The high price of medicinal marijuana was the primary concern raised so far. The price of medicinal marijuana can range greatly from one product to another and from one dispensary to another. Customers may be forced to shoulder a greater share of the cost associated with cultivation and retail sales than originally anticipated due to the wide variety of taxation regulations in place across the country.
Advantages to Using Medical Cannabis Treatment in Australia?
Medical marijuana has been demonstrated to be effective in treating a wide range of illnesses that commonly affect the elderly.
- Medical marijuana is helpful for treating the symptoms of multiple sclerosis, including the pain, muscular spasms, and urinary issues associated with late-onset MS.
- The onset of Alzheimer’s. A small amount of Tetrahydrocannabinol (THC), a chemical found in cannabis, was found to slow the production of beta-amyloid proteins, thought to be a signature characteristic and major contributor to the progression of Alzheimer’s, in a preclinical study published in the Journal of Alzheimer’s Disease.
- Cancer. Research suggests that marijuana can help with the nausea and discomfort linked with chemotherapy and other cancer therapies.
- Constant suffering from discomfort. The effectiveness of prescription therapies for pain management might wane with time, but research shows that marijuana can help.
- Patients with glaucoma claim that cannabis helps lower intraocular pressure.
- Arthritis. Medical cannabis has been shown to be effective in the treatment and management of arthritic symptoms because to its immune-modulating and anti-inflammatory effects.
- Coronary illness. Cannabis’s anxiolytic and stress-relieving properties make it an ideal complement to a healthy lifestyle that includes regular exercise, plenty of restful sleep, and a nutritious diet. Patients with diseases like angina can benefit from marijuana’s pain management properties as well.
- Diabetes. Substantial evidence suggests that diabetes may be prevented or treated with medical marijuana due to its ability to reduce insulin resistance, alleviate pain, and fight oxidative stress and inflammation.
- Fibromyalgia. Undiagnosed and excruciating pain is the hallmark of Fibromyalgia, but the disease can also cause other symptoms such as exhaustion, poor sleep, depression, and irritable bowel syndrome (IBS). Cannabidiol (CBD) has been shown to provide a wide range of therapeutic benefits, including the enhancement of sleep quality, reduction in pain, elevation of mood, and the treatment of gastrointestinal disorders including irritable bowel syndrome.
- Osteoarthritis. cartilage between joints breaks away, causing bones to rub against one other, causing the most frequent form of arthritis afflicting the elderly. Pain, stiffness, discomfort, loss of flexibility, bone spurs, and edoema are just some of the negative effects this can have on the body.
Repercussions for the Elderly
- Impairment of memory, especially of recent and verbal memories. Memory loss linked with marijuana usage may be indistinguishable from that associated with the start of dementia in older adults, which might impede accurate diagnosis.
- Those who are experiencing the early stages of dementia may misinterpret hallucinations (often linked with some harsher strains of marijuana).
- Health of the mind. Some mental diseases, including psychosis and schizophrenia, have been linked to marijuana use. Depression and bipolar illness should be considered together.
- Another potentially fatal consequence of marijuana usage is an increased chance of falling.
- For elderly people who may be overweight to begin with, over eating can have serious consequences.
- Illnesses related to the respiratory system. Chronic marijuana use has been linked to persistent coughing and increased mucus production. Marijuana usage may worsen lung issues in people who already have them.
Dangers of Medical Marijuana for The Elderly
Medicinal cannabis can cause undesirable side effects, including:
- Paranoid delusions
- Difficulty focusing
- Feelings of euphoria
- Confusion dizziness and drowsiness
- Unsteadiness, fatigue, and sedation
- Vertigo, nausea, and vomiting
- Appetite (increase or decrease)
Method for Elderly People to Use Marijuana?
THC and CBD are the psychoactive and therapeutic components of marijuana, respectively. While cannabidiol (CBD) is responsible for marijuana’s anti-anxiety properties, tetrahydrocannabinol (THC) is responsible for the “high” associated with marijuana. Numerous elderly people are seeking symptom relief without seeking euphoria. Therefore, it is recommended that they begin with the lowest effective amount of THC since they do not want any effect on their ability to think.
Is There Evidence That Marijuana Use for Medical Purposes Endangers the Elderly?
Many medications, especially those designed to treat the elderly, come with potentially fatal adverse effects, even when used properly and not for recreational purposes. Opiates can weaken a person, leading to an increased risk of falls and mental disorientation.
Medical marijuana is highly safe. Many of the dangers of opiate usage are mitigated when they are used appropriately and under supervision. Furthermore, there is no longer any danger of overdosing to the point of death.
To know more about where to buy medical cannabis in Australia and other medical marijuana resources, you should book a consultation session with a professional from Chronic Therapy today.

domain: medical


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Global rows over what technology farmers can use may come to a head, as the glyphosate spotlight falls in Brazil.
In August, a Brazilian judge ordered the sale and use of glyphosate to be suspended until the Brazilian Health Regulatory Agency concludes a toxicity re-evaluation.
In news terms, this was probably overshadowed by a California jury in the same month finding Monsanto liable in a lawsuit, and ordering it to pay $289 million in damages to a man who alleged the company’s glyphosate-based weed-killers, including Roundup, caused him cancer.
In any case, the injunction in Brazil was overturned earlier this month, but proponents of the ban on glyphosate may still appeal the overturning decision.
If the ban returns, and remains in place, there could be difficulties in controlling weed infestations in Brazil’s next crop season, due to the country’s high dependency on the product.
So say global agri-trade analysts at Rabobank, who go on to explain the huge significance of the potential setback for Brazil’s soy crop.
Rabobank expects the recent temporary suspension of glyphosate to have only a small impact on Brazil’s soybean expansion, even though glyphosate has become the most important herbicide used in Brazil, because of the widespread use by Brazilian soybean farmers of crops genetically modified to be glyphosate-tolerant. Using this GMO technology, farmers were able to do more no-till farming, and simplified weed control, thus saving time and money. From about 50% of the Brazilian soybean crop in 2005, GMO soybean (glyphosate-resistant) has increased to 97%.
This enabled soybean to become the main crop in Brazil, both in scale and in value.
The country is the world’s second biggest grower, producing nearly one third of the global crop, and on course to pass out the United States as the No 1 grower in the coming decade.
Technological efficiency for production in tropical lands, availability of arable lands, and entrepreneurial farmers, have helped Brazil become the largest soybean supplier to China, delivering 57% of the imported soybean China needs for its vast livestock operations, to feed its increasingly prosperous 1.4 billion citizens
Therefore, a lot of people around the world were depending on the recent legal battle after a Brazilian judge determined at the beginning of August that Anvisa (the Brazilian Health Regulatory Agency) had to suspend registry of all products containing glyphosate before September 3, and finalise a re-evaluation of toxicity by December 31.
The injunction was overturned earlier this month, because of the importance of glyphosate in Brazil’s agriculture, and the timing of the injunction just before Brazilian farmers start planting the 2018/19 crop. If a follow-up court appeal rules out glyphosate again, farmers will have to find substitute herbicides, likely to increase their expenditure on herbicides by at least 80%, or the equivalent of €26 plus per hectare.
Most of the soybean acreage expansion expected this year would take place on underused pasturelands, but higher costs without glyphosate may make this unfeasible. And Rabobank analysts say the scenario of farmers being unable to use glyphosate, and unable to find enough substitute products, cannot be ignored. As glyphosate replaced the substitutes in recent decades, their production and stocks level were rundown.
This means that the glyphosate ban could cause unpredictable losses in soybean yields and in the Brazilian crop size, with reverberations across the world — such as the possibility of China going hungry. That’s why any measure to limit use of crop protection has to consider the ability of farmers to find substitute products, said Rabobank experts.
Brazil recently banned the paraquat herbicide, banned in the EU since 2007. But the Brazil ban won’t enter into force until 2020, following a three-year transition period. An even longer transition period would be needed to allow Brazilian — and global — transition to a glyphosate herbicide ban.

domain: agronomy


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The Kochi-Muziris Biennale: India'S First Biennale Of Contemporary Art In Kerala
"The Kochi-Muziris Biennale could be one of the greatest things to happen to contemporary art in India". - Atul Dodiya - an Indian artist. The city of Kochi is in Kerala, south west India. Situated on the coast, the sight and sound of the sea is never far away. Kerala and the city of Kochi have a long history: nearby Tripunithura has a prehistoric menhir and the Muziris excavation reveals a port dated 1AD.
Kerala in south west India, the home of coconut groves and matriarchy, is also the home of Raja Ravi Verma, once scorned and now adored with equal passion. The general public have always loved his colorful, mythological prints for their homes.
Two internationally established artists, Bose Krishnamachari and Riyas Komu, have now organised India's first contemporary art biennale: the Kochi Muziris Biennale (KMB) at Kochi, in Kerala. KMB began officially on 12 December 2012 and will continue until 13 January 2013. Bose said his three-month long biennale is possibly “the country's largest exhibition of contemporary art”. Komu added that while ‘KMB is not exclusive’, they had to choose to whom to allocate sites.
In 2010, KMB received approximately $US1 million from the Marxist government then in power in Kerala. The Congress Party, now in power, apparently with-held funds but fortunately institutions supported the controversy-ridden KMB. Many artists promptly and painstakingly raised money to travel and present their art. Ninety contemporary artists, some renowned, some with local promise, are exhibiting works in a range of mediums including: paintings, sculpture, installations, and video, It is a really a wonderful, slightly whimsical festival of contemporary art displayed in six historical venues.
Josef Semah’s (Baghdad) wood and copper creation, 72 Privileges, describes the support given to Jews and Christians by Kochi’s Hindu Raja in the 8th century. Subodh Gupta’s huge Kerala rice boat lies in one hall. It somehow feels tragic, laden as it is with the flotsam of human lives and seems to evoke reports of flight, of families hastily carrying belongings: events the rest of us would rather forget. Gupta’s work often involves ordinary everyday goods, what we all depend on daily: bowls, spoons, a chair or a fan.
Next to Gupta’s boat, lies Sundaram’s Black Gold. Here Sundaram evokes Kochi and its twin, Muziris, smothered by mud and myths after a massive flood or earthquake in the 14th century. He was inspired after meeting Dr. P. J. Cherian, who is investigating the excavation. When the historian said ‘millions’ (of tiny pottery shards), Sundaram stopped him: he had found his inspiration, he had discovered one city and could create another. He borrowed the shards and reflected on how the sea might have kneaded sand and shifted a city’s stones into shapes. He stirred in 15 kilos of black gold, (pepper) to create ‘a strange, mysterious landscape like maybe the Moon’. Black gold, the reason Europe sought India.
The Gujarat girls, Zeal Parikh, Harshika Ameen and Pooja, chose Kerala umbrellas (muthukuda), hung coconut shells and drew colorful pictures of sights around Fort Kochi. L Zhang Enli’s watercolours are inspired by the ‘unforgettable songs and dances’ of Bollywood films.
Bengaluru’s famous Sheela Gowda often uses quotidian things like a dangling red rope or human hair in odd, unusual ways, which make you stop still. Concerned about home and gender, she brought 170 pieces of granite kitchenware. These huge and heavy stones are traditionally used for grinding pulses and spices for daily meals. The notes to the work state they were once ‘thought to be unmovable parts of homes and lives’, and so she moved them to Kerala. Why 170 pieces? She does not say.
South African artist Clifford Charles bases his work on objects from the streets and painted an Enfield motorcycle rather cheerfully. The Gujarat girls, Zeal Parikh, Harshika Ameen and Pooja, chose Kerala umbrellas (muthukuda), hung coconut shells and drew colorful pictures of sights around Fort Kochi. L Zhang Enli’s watercolours are inspired by the ‘unforgettable songs and dances’ of Bollywood films. The US-Afghan artist Amanulla Mojadidi said his Sufi ancestors had travelled from Kabul to India and back in the 17th century and so he dreamed and built a home they might have lived in. He wonders, “What was their journey like, did they feel safe, were they nourished by their travel?”
Australian artist Daniel Connell works with charcoal to sketch Achu, the tea vendor and a few fishermen: Benjamin, Anees, Peter, Joseph, Saifu, Verghese and Felix, all now local heroes. A passerby reiterated someone’s words, “He is etching unknown faces from the tropical coast: first in his heart, then on his canvas”. Humanity so often loves the ordinary, the homely and the comforting.
Amar Kanwar’s amazing use of technology shows videos on handmade pages where words describe Odisha’s farmers and the sad, immensely dangerous loss of biodiversity. This situation presents a huge threat as humanity loses grains with traits like great resistance to difficult conditions like drought or certain pests. In one devastating book, each page simply carries the name of a farmer who committed suicide thanks to the terminator seeds. He said if peasants’ land is stolen, their centuries old knowledge of farming will disappear. His work blurs books and film as he debates resistance and ‘clarity, even temporary clarity’. All clarity, he adds, is temporary, all comprehension has contradictory elements.
Mihaela Brebenel’s film, Auditions for a Revolution, addresses the fall of communism in Romania in 1989 when the world witnessed the first televised revolution. The film shows besieged, occupied TV studios in Bucharest followed by a trial and an execution, telling us tales of the preciousness of freedom and survival.
Vasco da Gama landed at Kerala in 1498 and so the Portuguese artist, Rigo 23 examines Kappiri, (African slaves), brought by Portuguese colonisers to Kochi. Hindu kings have historically welcomed every religion and he realized that the Kappiris, like all visitors, were encouraged to build their own temples. He brought 10-metres of bamboo reeds and coconut coir to an old, disused Kochi shipyard and paired his Kochi Tower with Lisbon’s 16th century Belem Tower. He speaks of Kappiri, the black slaves killed by the Portuguese before they left and his Echo Armada, tells ‘untold stories’. Through his cylindrical work, we see a container terminal. A figure represents Talappana Namboodhri, the Hindu priest murdered by Vasco da Gama who cut off his ears and stitched on dog ears. Rigo 23 uses temple lights to honour those who welcomed the Portuguese and were subsequently murdered.
Kochi’s officials declared, “The Kochi-Muziris Biennale could lead to a surge in the number of people wanting to take up art professionally”. The Biennale was hailed as the “real emerging Kerala, a novel aesthetic experience”. Kochi is brimming with creativity and inspires all who visit. — [O]
Swapna Vora has written on Indian art for years. She was VP at Asia TV Network, GM at UTV, and editor at the Taj magazine and the Indian Express, North America. She has lived and worked in Hong Kong, Kenya, Lebanon and Britain and misses them all. She now works in America and India.


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The Charlatans at Brixton Academy
During the Covid-19 pandemic, Tim Burgess became something of a patron saint of indie bands and fans – with his Twitter listening parties providing a much-needed distraction from lockdown. He also found time to work on solo projects but is now back with the band that made his name, The Charlatans, who were truly on form when they played the Brixton Academy on Friday.
The term ageless is most often used for plasticised Hollywood stars but is perhaps best applied to Burgess, with his mop of blonde hair that bounces on stage to the psychedelia of Forever. From there, it’s a hit-heavy opening act to the show – and it is an opening act, as he and bandmates Mark Collins, bassist Martin Blunt and keyboardist Tony Rogers will get through more than 20 songs in total.
There’s an early focus on their 90s heyday; lesser (but no less fun) hits like Weirdo are blended with classics like You’re So Pretty…We’re So Pretty, Just When You’re Thinking Over and One to Another. For an audience who has perhaps aged less gracefully than the group’s frontman, each provides a thrilling window into lost youth.
Ordinarily, a turn towards newer material during a classic band’s greatest hits gig – as The Charlatans make in the middle section – would be a disappointment, or a cue to head to the bar. But here it kind of works: songs like Different Days and Plastic Machinery may not have the same cachet in the group’s songbook as their earlier hits, but they mix in well with them and provide something of an interlude that means the occasion is not just about looking back, but a band still interested in making music – and telling stories, so to speak.
To finish, though, it’s of course back to the 90s, as a Charlatans gig wouldn’t be complete without their first hit, The Only One I Know from way back in 1990, a song that has always acted as something of a calling card. It’s accompanied by the anthemic North Country Boy and raucous How High, before an encore that closes another early classic – the Madchester-influenced Sproston Green.
Burgess and The Charlatans are some of 90s-indie’s great survivors. Unlike many of their contemporaries who called it a day only to reemerge in recent years on the nostalgia circuit, they and Burgess have kept making and loving music – and the result is a varied set that feels fresh even though it’s anchored around hits older than the youngest fans in attendance. The band prove a gig is more fun than even the best listening party.
For further information and future events visit The Charlatans’s website here.
Watch the video for the single Sproston Green here:


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Once you realise and accept(if you can) that what is depicted in Valentino is far from what really happened then you will find a lot of enjoyment here. Ken Russell has done better with Women in Love, The Devils and The Music Lovers(also his even better composer documentaries, apart from the Richard Strauss one), it is though certainly more watchable than Lisztomania. The storytelling, told in flashback structure, is jumpy in places which makes it not always easy to follow and I agree that the characters are written flatly, they're very well played but you wish that you learnt more about them. Plus Rudolph Nureyev is a very mixed bag in the title role, he is an incredible dancer(in ballet one of the greats, his chemistry with Margot Fonteyn perhaps unparallelled) and it shows in the beautifully choreographed dance routines, the tango especially, he was also a very handsome man, his chemistry with his colleagues credible and does show some expressive acting in the dances. His dialogue delivery is another story, often very awkward-sounding and at times incomprehensible, and while charismatic and athletic his acting outside the dance routines was at times too subtle and not matching with the acting style of films from the first twenty years of the 20th century.
Leslie Caron however looks as though she was having a whale of a time and is gleefully enjoyable, while Michelle Phillips is more restrained and is touching and delightful. Felicity Kendall is also very involved and Carol Kane and Seymour Cassell delight. Ken Russell writes himself in and is thankfully nowhere near as embarrassingly bad as he was in Salome's Last Dance. The music is fitting, it captures the period beautifully and is used in a way that enhances the atmosphere yet accommodates the more dramatic elements. Visually Valentino is a gorgeous film to look at, one of Russell's most visually pleasing films. The sets and colours are lavish and the costumes, hair-styles and make-up are unmistakably 20s. The dance scenes show off Nureyev's talents really well and are intoxicating, while the sexual moments are mostly sexual but sometimes gratuitous. The script is appropriately dark-humoured and sharply biting, you cannot resist how Valentino's conflicts with different people(mainly moguls hungry for power and actresses) are depicted, even if it doesn't say a lot about the characters. Russell like his actors seems to be really enjoying himself, the film is full of his style which goes to go how much the direction shines. And thankfully his stylistic touches while not exactly restrained are not overly-excessive or distasteful, Caron's entrance at the funeral is eye-poppingly operatic, while Valentino's jail encounter, the fight sequence and the staging of the funeral are every bit as entertaining and grandly staged, managing to do so in a way that is not too overblown. In conclusion, not for people expecting a history lesson(and that is not meant to sound derogatory if it does come across that way, more as a forewarning as to what to expect) but for a well-made film that does spark at least an ounce of interest Valentino is worth a viewing. 7/10 Bethany Cox
Action / Biography / Drama
Action / Biography / Drama
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In 1926, the tragic, untimely death of a silent-screen actor caused female movie-goers to riot in the streets and in some cases to commit suicide. That actor was Rudolph Valentino. Ballroom dancer Valentino manipulated his good looks and bestial grace into a Hollywood career. His smoldering lovemaking, tinged with masterful cruelty, expressed a shocking sexuality.
Uploaded by: FREEMAN
March 03, 2016 at 09:31 AM


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Mesilau Nature Resort
Imagine being surrounded by 600 million years old of rainforest and pampered by attentive staff and luxurious accommodation. The feeling can be described as just ‘awesome’. Mesilau is a brand new nature destination at its best.
Located in the Kinabalu area, Mesilau stands in between the Kinabalu Park and the Poring Hot Springs. Its elevation is at approximately 2,000 metres above sea level. One will feel a strong sense of nature as Mesilau is on the Pinousuk Plateau which is richly endowed with flora and fauna. The cool climatic condition in the highlands combines with the mist and evergreen environment creates an exotic and mysterious atmosphere.


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WINNER: The News-Press Athlete of the Week April 10-15
Canterbury tennis player Emily Javedan carried 60 percent of the vote to earn The News-Press Athlete of the Week honors for April 10-15.
Nominees are derived from scores and stats called and emailed in by Lee County’s coaches during the week. Voting begins each Monday at 2 p.m.
Coaches can email scores to firstname.lastname@example.org. The deadline for each night’s results is 10 p.m.
Javedan earned an automatic berth into the Class A state tournament with a three-set victory at No. 1 singles and teamed with Anna Sofia Diaz to win at No. 1 doubles to help the Cougars take the District A-10 team championship on April 12.
Canterbury lacrosse player Xander Peden finished second with 29 percent of the vote. Peden made eight first-half saves to hold Sarasota Riverview to only one goal in the first half of the Cougars’ first round play-in game, but it wasn’t enough as Canterbury was outscored 7-5 in the second half, ending their season with an 8-6 defeat.
Other nominees were ECS tennis player Joseph Manibo, Canterbury lacrosse player Peyton Hornung and Estero track and field athletes Evan Williams and Megan Giovanniello.


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This addon modifies the Mission Journal to have two new entries in the dropdown: Available Missions and Tracked Missions.
Available Missions: As you roam through the world, nearby missions that you have not yet completed will automatically be added to this section so that you will not forget to complete them. They will be removed once they are completed. Please be aware that this will include hidden missions such as seasonal or faction missions that are currently unavailable. However, these hidden missions will not be expandable, so you will not be able to peek at the details.
Tracked Missions: Simply click the new "eye" icon on any completed, repeatable mission to add it to the Tracked Missions list. Now you can more easily track important mission cooldowns in one place.
New official developer site: http://games.jupath.me/tsw/available-missions
Source code is available via git from curseforge.
If possible, please try to use the official forum for discussion in order to consolidate potentially useful information in one place.
* Updated to the 1.8 source code.
* The font now matches the game's font more closely.
* (fix) Packaged the wrong files in 1.3
* Added region filtering dropdown to Tracked Missions (still no good way to do it for Available Missions).
* XP reward line is now shown for all repeatable missions.
* Tightened up the spacing between missions in the list.
* Fixed clipping issue on the rightmost buttons.
* Fixed the scroll-to-top issue for good this time.
* Tweaked visibility of buttons so that valid actions should appear regardless of which journal section is active.
* Fixed Tracked Missions not updating when a quest is updated while the Journal is open.
* Added a Tracked Missions list. Just click the "eye" icon on any repeatable, completed mission to add it to the list.
* Something went wrong with the font embedding in the previous version. Fixed.
* Updated for patch 1.4.
* Yes, I know the scroll issue when expanding/collapsing still exists - I've tried everything I can to fix it, and nothing seems to work.
* Fixed font (now contains all characters so words like "Drăculeşti" appear correctly.
* No longer scrolls to the top when expanding/collapsing entries. Well, ok, actually it does, but then it scrolls back down. This can be a bit jumpy sometimes, but it's better than having to scroll the window constantly.
|File Name||Release Type||Game Version||Downloads||Date|
|AvailableMissions_1.5.zip||Release||9,170||May 10, 2015|
|AvailableMissions_1.4.zip||Release||16,214||Oct 26, 2013|
|AvailableMissions_1.3-fix.zip||Release||10,480||Dec 8, 2012|
|AvailableMissions_1.2.1.zip||Release||219||Nov 26, 2012|
|AvailableMissions_1.2.zip||Release||150||Nov 22, 2012|
|AvailableMissions_1.1.2.zip||Release||195||Nov 17, 2012|
|AvailableMissions_1.1.1.zip||Release||60||Nov 17, 2012|
|AvailableMissions_1.1.zip||Release||619||Oct 21, 2012|
|AvailableMissions_1.0||Release||81||Oct 16, 2012|

domain: game


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FOXBORO - Antwaun Molden was a project when he came out of Eastern Kentucky in 2008. The Texans took him in the third round. The sentiment then was that he was probably taken too high.
FOXBORO It remains to be seen if New England's BenJarvus Green-Ellis can have a repeat of his career-day in last Sunday's win over the New York Jets.
The Patriots were without six players at Wednesday's practice, including Albert Haynesworth who did not play because of a back injury.
The Patriots were without five players at Wednesday's practice. Seven others were limited participants.


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Presented by Old Forester
Bite off some local flavor with Sonablast! Records as we kick off a weekend of killer parties in true Ketchum fashion. Musical guest The Pass, Louisville’s hottest psychedelic pop group, graces the stage with opening band the Kennan Moving Company. Entrance included in Festival and Party Passes.
Address: 251 N Main St, Ketchum, ID 83340 Phone: (208) 726-5297


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1 edition of Catalogue of a selection of old engravings illustrating the social and historical life in the British Navy found in the catalog.
Catalogue of a selection of old engravings illustrating the social and historical life in the British Navy
|Contributions||T.H. Parker Bros., Royal Institution of Great Britain.|
|LC Classifications||NE957.3.G7 C37 1914 Rosenwald Coll|
|The Physical Object|
|Pagination||19 p. ;|
|Number of Pages||19|
|LC Control Number||81211975|
Kidnapped by River Rats
Easy Beans/More Easy Beans
New England and Virginia
Matter & gravity in Newtons physical philosophy
Pro Arts 1991 annual.
Shipping Safety (IUP library of fundamental source books)
New directions in Soviet literature
Death and dying in the poetry of Emily Dickinson
Effective risk and insurance management in municipal government
story of Beatrix Potter
Scottish literature and postcolonial literature
Northamptonshire Yeomanry Association Annual Report and Magazine 1973.
From the heart
international symposium on aldosterone

domain: library


What is the Diabetes Vaccine? Does It Actually Work?
Rumors of a proposed diabetes vaccine have been circling the web since 2016, when the site Time for You shared an article claiming that one had been discovered. This article was notoriously false and was quickly shut down by health authorities as containing fraudulent and potentially dangerous information.
However, while the most popular reference for a diabetes vaccine was false, vaccinating against diabetes (Type 1) is becoming increasingly more likely through immunotherapy, to the point where there are actually several legitimate programs running clinical trials and tests towards reaching a diabetes vaccine.
The most famous of these is happening at the Finnish University of Tamprere, but there are also initiatives in the UK and at the University of Maryland, and any or all of them could pay off.
University of Tampere Diabetes Vaccine
The University of Tampere is home to a team headed by Heikki Hyöty, Olli H. Laitinen, and Hanna Honkanen that has spent the last 2 decades researching the link between viral infections and Type 1 diabetes. The team now believes that coxsackievirus B1 plays a strong part in creating the immune system response that destroys insulin cells in the pancreas. Because the link between Type 1 diabetes and viral infection is well documented to the point that researchers understand that viral infections most likely push malfunctioning immune systems over the brink into diabetes. However, every current study into a diabetes vaccine is looking into the overproduction of T cells, which then go on to target insulin beta cells.
While we still don’t understand why the body chooses to identify these beta cells as foreign, researchers hypothesize that the body’s HLA complex is malfunctioning, causing it to be unable to differentiate, possibly after exposure to coxsakievirus B1. While this explanation is highly simplified, it enabled researchers at the University of Tampere to identify Diabetes Type 1 patients significantly before their diagnosis. Cosackievirus is responsible for about a quarter of all entovirus infections in children, and researchers estimate that about 5% of CB1 infections manifest into Type 1 diabetes.
So, what about a vaccine? Researchers are moving towards a vaccine for CB1, with the intent of stopping one of the infections that is likely behind Diabetes Type 1. While this treatment option is moving into clinical trials in 2018, we won’t know if it’s successful for 8 more years.
What About Other Vaccines
There are several other vaccine initiatives, and all of them are taking a slightly different approach. For example, Denise Faustman at the University of Maryland is working to create a treatment option for people who have had a diagnosis for 5 years or more. Her research led her to notice that Diabetes Type 1 patients have an excess of T cells, with very low levels of a hormone known as TNF (Tumor Necrosis Factor). She is currently using Bacillus Calmette-Guerin, BCG, commonly known as the tuberculosis vaccine, to stimulate production of TNF in possible patients. And, while her trials are in the early stages, they are showing success, slowing the onset of diabetes, boosting the body’s production of insulin beta cells, and even restoring some insulin function.
In Germany, Ezio Boficacio and Annette Ziegler are also working on a vaccine, although their method takes a more unconventional approach. With decades of experience in establishing early identification for Diabetes in children based on the immune system and autoantibodies, the pair are now working on a possible oral insulin introduction to train the immune system to it, in much the same way that introducing peanuts early on can help to prevent peanut allergies. However, similar trials have been attempted in the past, with very little in the way of results.
And, in London, Mark Peakman, PhD, is focusing on treating the inflammation following immune system responses. He uses fragmented beta cells to attempt to stop T cell attacks on other beta cells, which would potentially cause them to identify insulin as harmless.
There are several other diabetes vaccines and studies in the works, many of which show promising results, and most of which are focusing on T cell reactions.
So, Are Diabetes Vaccines a Cure?
No. Like any vaccine, the diabetes vaccine would theoretically have to be administered before the onset of diabetes. Doctor Faustman’s approach is the only current ‘vaccine’ that could be relevant for people who already have a diagnosis, while every other option is aimed at preventing rather than curing the disease.
Unfortunately, if a diabetes vaccine were to result from existing market research, we likely won’t see it for more than 20 years. However, with multiple advancements, we are getting closer to preventing and treating type 1 diabetes, without insulin.


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Published: July 4, 2021
BELCARRA (NEWS 1130) — Fraser Health has issued a warning to those who were at White Pine Beach in Belcarra Saturday, as a group of people were seen handling a wild bat.
The health authority says nine people were spotted on the floating dock touching and handling an injured bat.
It’s now asking for those people to head to a hospital immediately so they can be tested for rabies.
Were you in direct contact with a bat last night at 7:45 p.m. at White Pine Beach in #Belcarra? If so, seek medical assistance immediately. Go to the nearest emergency department to be assessed for possible #rabies exposure: https://t.co/c6C8vokqPy pic.twitter.com/JpN3jZ1bzt
— Fraser Health (@Fraserhealth) July 4, 2021
Although the chance of contracting rabies from a bat is very low, if someone is infected with the deadly virus, they need to receive treatment immediately.
“While the prevalence of rabies among bats is low (less than one per cent of all bats), the health risks of rabies are severe,” a statement from the authority reads.
Fraser health is also reminding the public that it’s never a good idea to touch or feed a wild animal — for this exact reason.
Adding, if you come across an injured animal, you should contact the BC SPCA Provincial Call Centre on 1-855-622-7722


Clayton Classic Barrel Heater
The Clayton heater was used in 1960's Jaguar saloons as well as cars from Daimler, Alvis, Lea Francis, Armstrong Siddeley, Rover and the Land-Rover S1.
It is also very similar to the Smiths unit fitted to Morris, TR3, Austin-Healey and Jaguar XK.
This is a single speed 12V motor. The unit can be specified with a 6V motor for an additional charge as a special order item.


New Years Eve Announced!
I am writing to you from the road. It’s 100+ degrees on the pavement today, but we are headed for the cool mountains of Virginia. Tonight we are playing at the Front Porch Festival, tomorrow we are at the Route 23 Music Festival, and on Sunday we return to Charleston to celebrate the Charleston Pour House’s 12th birthday! What a fun weekend! Our summer tour continues after Labor Day with shows in DC, Nantucket, Raleigh, and Charlotte. We wrap the tour up at the ever-epic Bristol Rhythm and Roots Festival before heading home for our drummer, Wes Powers’ wedding.
The new touring lineup is feeling good, on and off stage. We have working on some new songs, and tweaking the arrangements to freshen some of our older material. Matty is doing a great job on the bass, and Ross is killing the keyboards and adding some nice vocal harmonies. An acoustic set is in the works, where we will bust out the ukuleles and banjo in a campfire style jamboree. We plan on trying out a few songs this weekend in this new “unplugged” configuration.
We are still working on the new album, Dance!, despite not reaching our kickstarter goal. Thanks to all of you who pledged and pre-ordered the cd. Since we didn’t reach our goal, we didn’t get any of the funds. Like “Casey at the Bat,” we swung for the fences…….and struck out. It’s back to the dugout to regroup and sharpen our skills for the next at bat. We are planning another pre-order campaign for Dance! that will go straight through our website, rather than a 3rd party crowd funding site. Stay tuned for an upcoming announcement about this campaign next month. We are really excited about these tunes, and can’t wait for y’all to hear them.
Joel, Ward, Russ, Wes, Ross, and MattyOL DRIVEN TRAIN :: NEWS


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Jamiroquai Are The Second Act Announced For The 2019 Emirates Airline Dubai Jazz Festival
Yesterday we annouced that Snow Patrol will be headlining the 2019 Emirates Airline Dubai Jazz Festival Presented By Mastercard, and today we can reveal that the second act to appear at the festival will be Jamiroquai.
Performing on the 21 February, 2019, the jazz-funk band will return to Dubai for the first time since 2013. Jamiroquai – fronted by Jay Kay – have three UK #1 albums, over seven in the UK Top 10 charts and have sold over 26 million worldwide albums.
Done Events are expected to announce the final headliner tomorrow, on Wednesday 28 November.
The 2019 Dubai International Jazz Festival will run from, 20-22 February, 2019 at Dubai Media City Amphitheatre.
Tickets start at Dhs350 for regular, Dhs550 for golden circle, Dhs750 for lounge access, Dhs1,250 VIP access.
INFO: Tickets available now from 800tickets.com


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Goodreads helps you keep track of books you want to read.
Start by marking “The Case of the Volcano Mystery (The Adventures of Mary-Kate and Ashley, #8)” as Want to Read:
The Case of the Volcano Mystery (The Adventures of Mary-Kate and Ashley #8)
When Mary-Kate & Ashley set out to explore the Mexican jungle, they meet three miners who are being chased by a monster. Mary-Kate & Ashley prove to the miners that it's not a monster, but they're not so sure what it is -- or why its footprints are covered with gray snow! It doesn't snow in the jungle, does it?
Paperback, 64 pages
Published August 1st 1997 by Scholastic
To see what your friends thought of this book, please sign up.
I hated this movie growing up, for the same reason I didn't like the book: Most of the adults are bumbling imbeciles. I don't like anything that portrays adults as incompetent, because I feel it gives children a bad impression. I know not all adults are of equal intelligence, but the adults in here are so ignorant it's not even funny. I'm sure it's meant to be, but it's not. My daughter (who's eight) loved it.
Other Books in the Series
The Adventures of Mary-Kate and Ashley (10 books)


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PARIS (Reuters) – The French financial system is on class to bounce back this quarter as a lot as it most likely slumped in the earlier a few months, the central financial institution believed on Monday, stating it may possibly need to have to revise up its 2020 forecast.
The euro zone’s 2nd-biggest economy could develop by an unparalleled 14% in the third quarter if exercise remains at minimum at recent stages, the Lender of France explained.
It approximated that the overall economy had shrunk an equally unprecedented 14% in the second quarter as France began emerging from a nationwide coronavirus lockdown, a little bit significantly less than its prior projection for a 15% contraction.
The governing administration imposed 1 of the strictest lockdowns in Europe in mid-March, plunging the financial system into a 5.3% slump in the initially quarter by itself. Lockdown limitations began to be lifted on May well 11.
The central bank estimated that the overall economy was functioning down 7% from standard levels, an enhancement from 9% previous thirty day period and 32% at the start out of the lockdown in March.
If the restoration keeps on observe and the outbreak continues to be under command, the Bank of France said it could revise up its forecast for a contraction of 10% this year, which is presently far more optimistic than the 11% slump predicted by the federal government.
Fusion Media or anybody associated with Fusion Media will not acknowledge any liability for loss or problems as a outcome of reliance on the information including information, quotations, charts and invest in/sell signals contained inside of this internet site. Make sure you be totally informed concerning the dangers and expenditures linked with trading the economic marketplaces, it is a single of the riskiest expenditure types doable.


text: Injuries are the single leading cause of death for American Indian and Alaskan Natives between the ages of 1 and 44 years. Unintentional Elder fall related injuries are a leading cause of hospitalizations in American Indians and Alaskan Native communities. Among older adults, falls are the leading cause of both fatal and nonfatal injuries. Implementation of prevention and modification strategies, some new and some currently in place with current programming will be a focus of this project. Strategies for the project will include home safety assessments with modifications, exercise programs for elders, elder fall community outreach and education including medication management, and fall/injury related questionnaires. It is important to maintain and improve the elder’s quality of life and prevent possible debilitating injuries. The intended beneficiaries of this project are elder’s age 55+.

domain: health


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Author has written 4 stories for Fifty Shades Trilogy.
Hi, I'm Ada.
I love books.
I've been writing since I was ten and my love for it grows every single day.
I write Fifty shades of Grey, The vampire diaries, and Crossfire, and Beautiful Disaster
And I even have four original stories of my own.
If you'd like to find me on Facebook my name is "Adamarie Fanfiction" I'd love to accept your request, the more the merrier
Thank you for reading. I love you All!!!
Also if you love my writing and want to continue to support me with my dream Give a like to my author's page
And you can find my First book on goodreads


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Ethical Issues in Phase I Cancer Clinical Trials
- Jeffrey PeppercornAffiliated withDivision of Hematology and Oncology, University of North Carolina at Chapel Hill Email author
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Phase I clinical trials in oncology are designed to study the toxicity of novel drugs and regimens in a small cohort of subjects and to establish a dose that can be used in future studies. Due to the toxicity of many antineoplastic therapies, these trials are typically conducted in subjects with advanced cancer and limited therapeutic options. Patients primarily enrol in phase I cancer trials with high expectations of personal medical benefit; however, the risks and benefits of these regimens are unknown and the benefit from enrolment in phase I cancer trials to date has been modest.
The use of a vulnerable population with high expectations of benefit in a scientific experiment creates challenges for the protection of human research subjects. To ethically use one human being for the benefit of others in a phase I oncology trial requires that the research subject never be viewed merely as a means to an end, but that their interests as a person are always respected and safeguarded. This process begins with trial conception and continues even after completion of the trial.
In trial design, particular attention should be given to the nature of the experimental agent or regimen and the most appropriate dose selection and escalation strategy and study endpoint. Older paradigms of inter-patient dose escalation and the establishment of maximally tolerated dose may not be appropriate for all studies. Once a well designed study has been established, the primary challenge is to ensure the voluntary informed consent of research participants. This process involves an explanation of the rationale for the study and details of what study participation actually involves in terms of schedules, drug administration, tests and procedures, and predicted toxicities. It also involves an explanation of the nature of phase I clinical trials with a focus on the nature of uncertainty in terms of risks and benefits, differences between trial care and prior care outside a trial, and the disclosure of any potential conflicts of interest and how these will be mediated.
Phase I oncology trials are critically important in the advance of the care of future cancer patients, but such advances must be achieved on a foundation of respect for today’s patients. Trial design and enrolment must be conducted in a way that lets those who choose to participate do so in a way that also maximises their chance of medical benefit, minimises their risk of harm, and maintains the principle of respect for persons at all times.
- Ethical Issues in Phase I Cancer Clinical Trials
International Journal of Pharmaceutical Medicine
Volume 20, Issue 4 , pp 233-242
- Cover Date
- Print ISSN
- Online ISSN
- Springer International Publishing
- Additional Links
- Industry Sectors
- Author Affiliations
- 1. Division of Hematology and Oncology, University of North Carolina at Chapel Hill, CB# 7305, 3009 Old Clinic, Chapel Hill, NC, 27514, USA


Source: Carib Flame
June 28 2015
It has now become absolutely clear that United States-based anti-Venezuela forces are currently using their agents in the Caribbean to try to subvert the growing friendship between the socialist Government of Venezuela and the nation-states of the Caribbean Community (CARICOM) by deliberately misconstruing the Venezuelan government’s policy and intentions in relation to that country’s one hundred year old border dispute with our sister Caribbean territory of Guyana!
This nefarious conspiracy must not be allowed to succeed, and it is therefore crucial that the Caribbean heads of Government who are meeting in Barbados this week for CARICOM’s 36th Heads of Government Summit examine the facts very carefully and issue a strong statement that exposes as a lie the fraudulent and mischievous assertion that is currently being peddled in the Caribbean news media that President Maduro of Venezuela has issued a decree in which he purports to appropriate a portion of Guyana’s territorial space.
Read more at: CARICOM Summit must dispel confusion over Guyana / Venezuela border issue Carib Flame