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Cannabis Delivering Distinctive Effects – Interview with Dr. Tristan Watkins Chief Science Officer LucidMood
Can you predict the moods cannabis is going to give you as an effect of consuming it? The answer is yes! In fact, the industry has been heavily exploring “effects” and how to produce the right interaction of terpenes and cannabinoids within strains given the demand for outcomes consumers are looking for.
We recently spoke with Dr. Tristan Watkins, a neuroscientist that studies how terpenes and cannabinoids interact with the nervous system and he applies this knowledge to creating cannabis formulas that deliver distinct and consistent effects.
His cannabis research began as a passion project during graduate school at Vanderbilt University, where he researched reward system activation in cannabis users and how changes in brain structure and function lead to changes in cognition and behavior – publishing six papers in the process.
Dr. Watkins currently serves as the Chief Scientific Officer of LucidMood, the leading brand of functional cannabis products and we sat down with him to talk about Lucid. Here’s what he had to say:
[Q.] Dr. Tristan, what drew you to get involved in the cannabis industry?
[A.] Absolutely! I just couldn’t wrap my head around how cannabis, and THC specifically, had so many different potential benefits. It didn’t make sense that THC alone could make someone feel alert yet sleepy, less anxious yet more paranoid, and many of the other reported effects.
So I started researching the plant as a whole, beyond THC. My research quickly uncovered a world or terpenes, flavonols, and other cannabinoids.
From there, I began researching the neurobiological effects of each individual compound naturally expressed in the cannabis plant. It became clear to me that curating and formulating specific compositions — and not just relying on full-spectrum extracts — would allow the typical cannabis consumer to experience dialed and differentiated effects.
[Q.] Tell us a little bit about LucidMood and how you fit into the cannabis industry?
[A.] At LucidMood, we are always looking to create unique experiences. That’s why we formulate all of our products from the ground up, based on current and ongoing research. We believe that cannabis naturally offers a variety of effects, and that we can highlight certain effects by selecting the perfect combination of cannabinoids and terpenes.
Our products aren’t just strains, but designer highs, allowing you to fully experience any moment.
[Q.] LucidMood focuses on reducing negative side effects that cannabis can sometimes bring with it in an effort to make the experiences wholly positive. What is the process of creating specific formulations in your pens to create clearer effects?
[A.] Less is more. Cannabis naturally expresses hundreds of unique compounds and many of these compounds point towards one particular effect.
Our formulations only contain compounds that point in the same direction, making a very clear and differentiated effect. If we were to add other compounds that point in an opposing direction, you would experience a muddled and unfocused effect, almost as if you are being pulled in multiple directions.
With LucidMood, you can easily select the best option to take you wherever it is you wish to go
[Q.] That’s incredible! What have been some challenges you’ve faced in the quest to streamline mood-specific effects of cannabis?
[A.] Although there is a solid amount of peer-reviewed literature on how individual terpenes act in the body, there is very little research on how these compounds can be combined to produce unique effects or experiences.
As such, our initial R&D efforts led to a number of missteps, dead ends, and even some unexpected successes. That being said, this is an inherent aspect of any new scientific field — someone needs to be the pioneer
[Q.] When it comes to cannabis products, what do you think customers should be aware of?
[A.] The two most important things to understand are that (1) there is so much more to cannabis than THC and (2) the indica v. sativa dichotomy limits the variety of effects cannabis can deliver.
THC is really only one of many neurobiologically active ingredients found in cannabis. These other ingredients, specifically terpenes and other cannabinoids, have a significant impact on how high you feel and how you feel.
Since cannabis can make you feel so many different ways, why do we simplify cannabis down to simply indica v. sativa?
Cannabis can help you feel alert, relaxed, intimate, giggly, dazed, exuberant, and many other unique ways. Consolidating all of these unique feelings into awake (sativa) or in-da-couch (indica) does a disservice to the beautiful complexity and multifaceted benefits of cannabis.
[Q.] Why is it so important to approach cannabis products with a perspective that keeps other terpenes or botanicals in mind, rather than just focusing on THC itself?
[A.] THC is only a single note of cannabis. It is the composition of the surrounding compounds that differentiates experiences, and the products that deliver those experiences.
In the same way that a mixologist delicately balances and bolsters flavors to create a uniquely memorable cocktail, LucidMood carefully curates the perfect composition of terpenes and cannabinoids for you to create memorable experiences.
[Q.] Speaking of products, we heard you have a new version 2 lineup, launching soon. Could you tell us more?
[A.] We never quit researching and discovering new ways to bring you the best possible cannabis experiences. Our new designer highs are 2 years in the making and we are extremely excited for everyone to see and try them.
We now offer a wide range of THC:CBD ratios, meaning you can more easily control how euphoric you feel. Our terpene compositions perfectly match these ratios, allowing you to partake in a distinctly rewarding experience.
[Q.] How does the V2 differ from your current product line?
[A.] The most obvious difference is that we expanded beyond the 1:1 THC:CBD ratio.
We now offer a 1:2, 1:1, 2:1, 4:1, and 8:1, which allows you to find your perfect mood throughout the day. We dramatically upgraded our pens and carts for better performance.
Visually, our new line is a stunning mix of vibrant color gradients and geometric patterning. When it all comes together, LucidMood delivers a brighter experience.
[Q.] How will the V2 elevate experiences and how will it transcend experiences current cannabis products offer out there?
[A.] We placed a great deal of effort into finding the perfect composition of cannabinoids and terpenes to elevate any moment of your day. One of the main ways we achieve this is by using CBD to reduce many of the unwanted effects that conventional cannabis products produce.
Our curated terpene blends deliver a bright, clean, high so that you can make the most out of your plans. LucidMood is more than just about getting high; it’s about fully experiencing a moment.
[Q.] What else would you like people to know about LucidMood going forward?
[A.] This is our passion. We believe that cannabis has much more to offer than we currently know, and our goal is to simplify the complexity of the plant — for you. In our continued passion for knowledge we will continue to research and develop new ways for people to interact with our products.
Thanks for speaking with Cannabis Magazine Dr. Tristan!
Thanks for having me!
Dr. Tristan Watkins – Neuroscientist & Chief Science Officer at LucidMood


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In this book the best-selling author Joyce Rupp inspires us not only to talk to God but to listen to the " still small voice of God" within us.
Author: Joyce Rupp
Publisher: Paulines Philippines
ISBN / AVN: 978-971-590-683-8
Weight: 300 g
Size: 5.25 x 8.25
Available In: Philippines, Malaysia, Papua New Guinea, Thailand, Singapore, Taiwan

domain: literature


text:
If Not Now, When? 3:250:00/3:25
Steve D. Wilson is an award-winning singer-songwriter and a veteran of both the Army and the Air Force.
Steve captivates audiences through lyrical poetry, delivered by soaring vocals. In addition to fronting the rock powerhouse, The Black Doves, Steve's songwriting has been highlighted during his time with Operation Encore: A Veteran Music Project, with whom he has performed to captivated audiences across the United States.
Soulful, emotionally deep with unforgettable hooks, Steve D. Wilson writes music for the heart.

domain: artistic


A reading passage from a Palestinian author assigned by an Orlando charter school has angered the mother of a child at the school and a Tennessee woman who rallies against the the “pro-Islamic indoctrination” of public school pupils.
Laurie Cardoza-Moore, founder of the group Proclaiming Justice to the Nations, appeared this week at an Orange County School Board meeting to complain about a passage read by ninth graders at Orlando Science High School, part of a charter school system that runs schools in three Central Florida counties.
In a press release issued ahead of the meeting, she called the passages from a novel by Liyana Badr “blatant anti-Semitic propaganda” and “disinformation” that would “promote violence against Jewish students.”
Wendy Nissan, a Winter Park parent, said her son attends Orlando Science and was “disturbed” by the passage, which she said focused on a “poor little Palestinian girl” and gave students a skewed and unfair view of Israel. “The only inference you can make is Israel is mass killing Palestinians,” Nissan said.
Three other local residents — none of whom identified themselves as parents whose children had been given the assignment — also spoke against the reading lesson at the board’s meeting.The speakers said the descriptions of Palestinian children shot at Israeli checkpoints was violent and misleading fiction.
Cardoza-Moore, an Evangelical Christian, describes herself as an advocate fighting the “crisis in American textbooks” and as part of “a global community of action and prayer in support of Jews and Israel.”
She wanted the Orange school board, Gov. Ron DeSantis and the U.S. Justice Department to investigate the reading assignment at the Orlando school, her press release said. At Tuesday’s meeting, shesaid she came to Orlando after being contacted by Nissan.
The Orange school board, however, has no say over what books or other curricula the charter school uses. Like other charter schools, Orlando Science is publicly funded but privately run. Though granted a contract by the Orange school board, it operates independently with its own school board.
The assignment an Orlando Science teacher used came from the Florida Department of Education’s CPALMS website, a collection of lesson plans and resources that teachers can use to help teach state academic standards. The website says the materials are “reviewed and approved” by educators and experts.
The lesson in question was titled “How Cultural Experiences Shape Perspective” and was designed for ninth-grade language arts classes. It has more than 24,000 “likes.”
The book from which the passage came tells the interweaving stories of three Palestinians from “the perspective we so rarely encounter: that of the disenfranchised people,” according to a description on Amazon.
A spokesman for the education department said every item on CPALMS “ undergoes an extensive review process” and the department had received no complaints about the lesson involving Badr’s book.
Yalcin Akin, executive director of Orlando Science schools, said after meeting with Nissan his staff agreed to review the assignment and will not use it again until speaking with state officials about the lesson. In an email, Akin said his schools aim to provide a high-quality education with a focus on technology but also one that prepares students “to work productively in a multicultural, globally-oriented environment.”
Nissan said she was pleased with its response but felt the problem needed wider attention. “This is a Florida state issue,” she said.
Orange administrators said they knew of no other complaints about that lesson. CPALMS, they noted, is available to any teacher who wants lesson-plan ideas and is widely used across Florida. Educators in Orange’s traditional public schools might have used the same assignment with their ninth graders, they said.
District curriculum leaders also will review the questioned reading assignment and decide if the concerns raised warrant telling teachers not to use that lesson in class, said Scott Howat, the district’s spokesman.
They will also let the state education department know about the complaints, he said.
Cardoza-Moore became a textbook advocate after finding “anti-Semitic, anti-Christian, and anti-American content in her children’s textbooks,” according to her website.
The Tennessean newspaper reported in 2015 that Cardoza-Moore “garnered national attention when she led efforts in opposition to a Murfreesboro mosque,” referring to her work to stop the expansion of a mosque in that city.
Those efforts in 2010 landed her on The Daily Show with Jon Stewart where she proclaimed, “We know we’ve got a huge terrorist network here in Tennessee.”
When asked by a Daily Show cast member where she got her information, she replied, “the Internet. All you have to do, I mean, Google and you can find out anything.”


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Real Madrid will travel to Seville on Saturday to take on Sevilla in a La Liga clash that could have a big impact on the standings. The visitors are currently second in the table, trying to hold on to the runners-up slot; while Sevilla are only one point away from the European zones.
Both teams are coming off contrasting results in their previous games. Real Madrid beat Rayo Vallecano 2-1 on Wednesday, thanks to goals from Karim Benzema and Rodrygo Goes. Sevilla, on the other hand, drew 1-1 with Elche.
The game will also feature some controversy, as Sevilla fans are unhappy with the possible involvement of Real Madrid’s Vinicius Junior. The Brazilian winger was initially suspended for this game after receiving a red card against Valencia, but his ban was lifted by the Spanish Football Federation (RFEF) after an appeal from Real Madrid.
Sevilla fans have accused the RFEF of favoring Real Madrid and have threatened to boycott the game in protest.
Real Madrid, meanwhile, are focused. Today they took the field at Real Madrid City to prepare for Saturday’s game. Carlo Ancelotti had almost his entire squad available. The only two players missing were Karim Benzema and Vinicius Jr, who trained indoors on their own.
Here are some photos from today’s training session:
On that note, if you haven’t already, please make sure to follow Managing Madrid on Instagram (Instagram.com/ManagingMadrid). Our chief editor, Kiyan Sobhani, answers questions from fans daily on our Instagram story.

domain: sports


Halloween is over on Season 4 of “American Horror Story” … but that doesn’t mean that the spooks and scares will slow down. FX has released the episode 5 synopsis of “Freak Show” and it teases possibly the most frightening plot to date.
“American Horror Story” viewers will remember that Twisty the Clown (John Carroll Lynch) was killed by urban legend Edward Mordrake (Wes Bentley) in the Halloween-themed episode 4. The frightening clown had managed to murder five people and kidnap a couple of more during his short stint on the mini-series. The townsfolk of Jupiter were overjoyed when Jimmy Darling (Evan Peters) was able to stop Twisty and free his prisoners – but what they didn’t realize is that Twisty inspired a new killer in town, Dandy (Finn Wittrock). Episode 4 of “American Horror Story: Freak Show” concluded with Twisty’s protégé cutting the throat of Dora (Patti LaBelle), Dandy’s family’s longtime maid.
According to the synopsis for episode 5, “Pink Cupcakes,” the murder and terror will continue … from a couple of different characters. Fans can look forward to seeing Stanley (Denis O’Hare) and Maggie (Emma Roberts) work together to con the freaks and profit from them. But Stanley and Maggie don’t want their money – they want “freak” body parts. The synopsis teases that Stanley, who is pretending to be a big Hollywood talent scout, will hatch a plan with Maggie to “murder the Freaks.” But will Maggie have a change of heart after spending time with Jimmy in episode 4?
Meanwhile, Gloria (Francis Conroy) will discover Dandy’s “gruesome new hobby.” Being the doting mother that she is, Gloria will hide the evidence of Dora’s murder. But only time will tell if she has to cover up any more of Dandy’s mess …
Finally, episode 5 of “American Horror Story” will explore more of Desiree’s (Angela Bassett) backstory. The three-breasted hermaphrodite will experience a “health scare” during “Pink Cupcakes” … and that health scare will reveal that “Desiree may not be the oddity she once thought.”
“American Horror Story: Freak Show” episode 5 will air on FX on Wednesday, Nov. 5, at 10 p.m. EDT.


Lenovo Ideacentre Y710 Cube Desktop (Intel Core i7-6700, 16GB DDR4, 1TB HDD + 128GB SSD, 8000, Windows 10) 90FL0017US
(as of May 23,2022 04:38:24 UTC – Details)
Lenovo IdeaCentre Y710 Cube combines pro-level gaming performance in a portable design for a truly flexible gaming experience. The Lenovo IdeaCentre Y710 Cube has an integrated carry handle and lightweight design. Powering through tasks with Intel processors, delivering breathtaking graphics via the NVIDIA GeForce GTX series cards and with ample storage space coupled with an optional lightning fast SATA SSD gamers can rest assured they are prepared for any challenge.
Intel Core i7-6700 processor, 3.4GHz
16GB DDR4, 1TB 7200RPM HDD + 128GB SSD


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Special E-newsletter: Operation UNITE and the National Rx Drug Abuse & Heroin Summit
In the midst of the nation's deadly opioid epidemic, it is important to highlight the ongoing work across the country to save lives and to plant hope for recovery. In Kentucky's Appalachian region, we have been battling this public health crisis since the early 2000s, when Oxycontin and other powerful painkillers caused addiction and accidental overdose rates to skyrocket.
Instead of hiding this stigma-ridden problem in our communities, we united and recruited help from every corner of the country to turn the tide of addiction with a holistic approach, including law enforcement, treatment and education. I shared our success story with the entire Republican Conference, hoping other communities can implement some of the same life-saving practices.
Today, I am proud to share it with you as well, to spur hope, encourage more advocacy, and to invite you to join this growing international movement to address what the CDC Director calls the "epidemic of our time."
Please take a moment of your time to watch the video below and learn how you can help save lives in your community.

domain: sociology


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Football is the prominent sport in Italy, but it wasn’t always so. There are many sports in Italy that are unique to the country and have their origins in its long and colourful history.
The Spanish have their bull fighters, the Japanese have the Sumo wrestlers, you don’t hear about them much anymore but at one time the pallonista was a national hero in Italy and professional players commanded the highest salaries of any professional athletes in the world and enjoyed the passionate support of their countrymen. […]
In 1992, thanks to some fans and to the passion of the Municipalities of Mondolfo, Treia and Monte San Savino, has been created the National Committee of the Pallone col Bracciale, with the aim to promote the recovery of historical game through cultural exhibitions , conferences and publications and promote the competitive aspect by organizing demonstration games, tournaments and a national championship. The new championship, was repeated at a distance of about thirty years since the last edition of 1963, in 1992
See on www.swide.com
I am passionate about Le Marche Region in Italy, follow me to discover it.
Latest posts by Mariano Pallottini (see all)
- Best Le Marche Accommodations: SeePort Hotel, Ancona - April 15, 2015
- Le Marche Inspired food in Washington - April 15, 2015
- Best Le Marche Accommodations: Hotel Leone Montelparo - December 26, 2014

domain: hobby


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Members of the Oireachtas Education Committee have visited a school being threatened with closure to see the facilities that could be lost to local children.
Three-hundred boys from the De La Salle National School in Ballyfermot are set to be transferred to a nearby campus with more than 1,000 pupils.
Under the proposal, the children will be moved into the Dominican schools - St Gabriel's, St Michael's and St Raphael's.
But parents have pleaded with Archbishop Diarmuid Martin to reverse the decision.
Martin Walsh, the spokesperson for the De La Salle Parents' Association, fears that if the local school amalgamation goes ahead it could see over 1,000 children squeezed into half the space they usually enjoy.
"We'll be losing resources in all four schools," said Mr Walsh.
"Education Committee members including Joanna Tuffy, Aengus O Snodaigh and Michael Conaghan attended the schools because of the public backlash against the proposed closures.
"They were able to ask their own questions such as would 320 pre-school and after-school places be kept open, the answer to which was 'no'," he added.
Parents argue that their children will lose the use of a new building at De La Salle that was built just under two years ago. It is currently used for a breakfast club. They are also concerned about the sports ground.
A spokeswoman for the Dublin Diocese has said that the decision to merge the school was due to falling numbers, but this is disputed by parents who say CSO figures show otherwise.
The spokeswoman also referred to the resources available to the students after the amalgamation.
"Pupils will still have use of the GAA pitch at De La Salle. Homework and breakfast clubs are available in the Dominican schools," she said.

domain: news


The Computer Music Production School has announced the launch of its RnB Radio Ready beat contest, an opportunity to battle with other producers for prizes, recognition and potential label release.
The RnB beats created will incorporate the sound made popular like Ne-Yo’s “Miss Independent”, “Rihanna’s “What’s My Name” produced by Stargate, Black Eyed Peas’ “Just Can’t Get Enough” and Mary J Blige’s “The One” produced by Dark Child. Catchy hook melodies, up-tempo drums, pop appeal, and originality are some of the criteria beats will be judged on.
Participants will have 30 days to submit material. Submission Deadline is April 15th. Only one track allowed per month/per entry. Submission fee is $10 and Computer Music Production School students participate free of charge.
More information: Computer Music Production School


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Wayne J. Anderson Joins Bank of Hawaii as Executive Vice President
Monday, March 20, 2017
HONOLULU, HAWAII –
Wayne J. Anderson has been appointed executive vice president and credit review manager of the Credit Review Department at Bank of Hawaii. His responsibilities include managing the credit review team and identifying, measuring and reporting credit risk issues and trends.
Wayne worked for BOH from 2008 to 2009 as senior vice president and credit review manager. Prior to rejoining the bank, he worked at MUFG Union Bank in San Francisco from 2009 to 2016 as a managing director in its Credit Review Department. Wayne has held management positions at several financial institutions spanning more than 20 years, including credit review manager for Greater Bay Bancorp in Palo Alto, Calif., senior credit examiner for Union Bank of California and special credentialed bank examiner for the Federal Reserve Bank, both based in San Francisco, Calif. Wayne was also a senior credit risk manager at Bank of America and performed real estate valuation and feasibility analyses at Arthur Andersen & Co. in San Francisco, Calif.
Wayne earned a Bachelor of Science degree in engineering mechanics; a Master of Science degree in manufacturing systems engineering; a Master of Science degree in real estate appraisal and investment analysis and a Master of Business Administration degree in finance, investments and banking. All degrees are from the University of Wisconsin in Madison, Wis.

domain: finance


There are lots of assumptions made about how far people are willing to walk. The golden standard in urban design for “walking distance” has long been held as 1/4 mile. It turns out that the distance one is willing to walk has a lot to do with the scenery! Another reason to support liveable city initiatives, and a fascinating read. The full article from Better! Cities and Towns available here.
Return to Blog


The press is reporting (a bit late) that the best surviving sword owned by Napoleon Bonaparte still in private hands was to be auctioned yesterday at Versailles by Osenat.
The sword is a Mameluke-style saber, a form of edged-weapon which became fashionable in France and Britain after Napoleon’s Campaign in Egypt in 1798.
The future Emperor, then First Consul, reputedly used this sword at the Battle of Marengo, June 14, 1800.
Napoleon presented the sword after the battle to one of his brothers as a wedding present. It has descended in the same family for eight generations.
Louis-FranÃ§ois (baron) Lejeune, Battle of Marengo, 1801
MusÃ©e National du ChÃ¢teau, Versailles, oil on canvas
1.8 m. x 2.5 m.
Doubtless stung by NYM’s criticism for slow reporting, Fox News has stepped up with the results of the auction. The sword sold for $6.4 million.
Hat tip to Frank. A. Dobbs.


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Have a frame you need to fill or want to start collecting a portfolio of work for a rainy day, our incredibly high quality Photographic Prints are just the ticket. Forget all this digital gubbins, display the photo the way it was meant to be seen.
Art comes in many shapes and sizes, and our photographic prints are ready to fit all of them. The final dimensions will depend on the image you choose, but to give you an idea here are the most common photographic sizes:
Featured in: Just FunFeatured in: Glitter Sparkle and shineFeatured in: A country road & a country view
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was born ages ago, lived uptill now and not gonna die anytime soon. And I did all this in the Netherlands.
dank je…was in sonsbeek park bij Arnhem….
– Nicole W.
Thank you so much Elaine!
lovely, congrats on the feature!
Thank you very much Sandra :-)
Very lovely !
Congratulatiions, your lovely image has been featured
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another feature! Thank you so much Morag!
Thank you so much!


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25 February 2010
Chikungunya infection in a French traveller returning from the Maldives, October, 2009
In the last years, cases of chikungunya fever have been reported in international travellers returning from the Indian Ocean region. The cases have been linked to the re-emergence of chikungunya fever on Indian Ocean islands in 2006. We describe the first case of chikungunya fever in a French traveller returning from Malé, an island of the Maldives islands, confirming the permanence of virus circulation by the end of 2009.
Chikungunya virus is a mosquito-borne alphavirus found in the tropical regions of Africa and Asia where it causes endemic and epidemic chikungunya fever, an acute self-limiting febrile algo-eruptive illness . Chikungunya fever has been increasingly reported in international travellers following its re-emergence on Indian Ocean islands and its spread to southern Asia thereafter [2-4]. Moreover, some African and south-east Asian countries show an endemic circulation of the virus  which may contribute to occurrence of the disease among travellers. The illness was suspected to have emerged in the Maldives archipelago in 2007 , following the sweeping succession of outbreaks that occurred in the Indian Ocean region where it first affected Kenya in 2004, Réunion Island in 2005 and southern India in 2006 [1,7]. Here we report a confirmed case of chikungunya fever in a French traveller returning from Malé island, the Maldives, where an outbreak of chikungunya fever was reported starting in January 2009.
A French male in his thirties presented at the post-travel clinic of the Department of Internal Medicine and Tropical Diseases of the University Hospital Centre, Bordeaux, France in October 2009 with symptoms of recurrent high-grade fever (up to 40°C), headache, generalised muscle aches and severe joint pain mainly affecting fingers, wrists, knees and ankles, and an itching skin rash, since three days. Two days before, he had returned directly from a holiday trip to the Maldives where he had stayed for 14 days exclusively in the northern part of Malé island.
In our centre, the patient presented with a slight macular skin rash on the trunk and limbs, a slightly swollen right knee and small joints of hands and feet. Laboratory tests at the time of presentation showed a leucocyte cell count of 4,600 white blood cells (WBC)/µL, a thrombocyte count of 178,000 platelets/µL and an elevated C-reactive protein level (27 mg/L; normal <5 mg/L). Alanine aminotransferase, aspartate aminotransferase and lactate dehydrogenase were within normal limits. Blood smears for malaria and blood cultures were negative.
Chikungunya virus serology testing was conducted for specific immunoglobulin (Ig) G and M using IgM-capture and IgG-sandwich enzyme-linked immunosorbent assay (ELISA) with inactivated cell-culture-ground chikungunya virus and mouse anti-chikungunya hyperimmune ascitic fluid at the National Reference Centre for Arboviruses, Institut Pasteur, Paris, France. Serology for chikungunya virus revealed positive results for both specific IgM (optic density (OD)=1.633; serum control OD=0.073) and IgG (OD=0.475; serum control OD=0.096).
Paired serology for specific IgG and M by ELISA against dengue virus and Japanese B encephalitis were negative, as well as tests for leptospirosis, rickettsiosis, Q fever, West Nile virus and cytomegalovirus. A real-time PCR test was negative for dengue viruses and chikungunya virus RNA . Fever decreased the day following the consultation, but severe joint pain persisted over six weeks until the end of December despite symptomatic treatment.
Over the last couple of years and following successive waves of outbreaks in the Indian Ocean area since 2006, chikungunya has increasingly been reported in travellers returning from vacation in the region and in expatriates or immigrants back from visits to their home countries [2-4,9].
The new case described provides definite evidence of ongoing chikungunya virus transmission in the Maldives. To the best of our knowledge, this case is reportedly the third confirmed chikungunya fever case imported from the Maldives since the first documented outbreak of chikungunya in Malé and other islands of the Maldives that lasted from December 2006 to April 2007 , followed by a suspected cluster on the Laamu Atoll from December 2008 to January 2009  and the report of two confirmed cases in German travellers, a father and son returning from a 10-day visit to the Maldives mid-September 2009 .
The region is probably one of the most popular travel destinations in the Indian Ocean area. This may result in an increase of symptomatic travellers returning from this area and seeking medical advice at travel or primary care clinics. Hence, chikungunya together with dengue fever should be considered as an important differential diagnosis in those patients, assuming that both diseases are endemic in certain regions of India and the Indian Ocean area and may present with similar symptoms.
For more than 10 years, dengue fever was the only vector-borne viral disease reported in the Maldives. Aedes aegypti and A. albopictus, the dengue virus vectors which can also transmit the chikungunya virus, have been identified in the Maldives, with A. aegypti identified as the predominant vector in Malé . The first chikungunya fever outbreak occurred from December 2006 to April 2007 with abrupt onset and high attack rates due to the lack of herd immunity. Epidemics may occur following an interval of 20-30 years of the virus not circulating as has been the case in western Africa and Malaysia [5, 6]. Confirmed imported cases among travellers support the assumption of endemic circulation of the virus which is consistent with the prevailing chikungunya epidemic in the Indian Ocean region.
This report highlights the need for surveillance in countries where emerging infections may be introduced by returning travellers as in the case with the Italian chikungunya fever epidemic which occurred in the province of Ravenna in 2007 . It illustrates how travellers can serve as sentinel population providing information regarding the emergence or re-emergence of an infectious pathogen in a source region. Travellers can thus act as carriers who inadvertently ferry pathogens that can be used to map the location, dynamics and movement of pathogenic strains . Thus, with the increase in intercontinental travel, travellers can provide insights into the level of the risk of transmission of infections in other geographical regions.
We report a case of dengue-like illness diagnosed as chikungunya in a tourist returning from the Maldives, a popular tourist spot. Despite the clinical similarity with dengue fever, chikungunya should be recognised early in returning travellers because of its specific protracted morbidity and its potential for causing local outbreaks in European countries, where local transmission is possible through the presence of the receptive vector in southern European countries.
- Renault P, Solet JL, Sissoko D, Balleydier E, Larrieu S, Filleul L, et al. A major epidemic of chikungunya virus infection on Reunion Island, France, 2005-2006. Am J Trop Med Hyg. 2007;77(4):727-31.
- Taubitz W, Cramer JP, Kapaun A, Pfeffer M, Drosten C, Dobler G, et al. Chikungunya fever in travellers: clinical presentation and course. Clin Infect Dis. 2007;45(1):e1-4.
- Larrieu S, Pouderoux N, Pistone T, Filleul L, Receveur MC, Sissoko D, et al. Factors associated with persistence of arthralgia among chikungunya virus-infected travellers: report of 42 French cases. J Clin Virol. 2010;47(1):85-8.
- Simon F, Parola P, Grandadam M, Fourcade S, Oliver M, Brouqui P, et al. Chikungunya infection: an emerging rheumatism among travellers returned from Indian Ocean islands. Report of 47 cases. Medicine (Baltimore). 2007;86(3):123-37.
- AbuBakar S, Sam IC, Wong PF, MatRahim N, Hooi PS, Roslan N. Reemergence of endemic Chikungunya, Malaysia. Emerg Infect Dis. 2007;13(1):147-9.
- Yoosuf AA, Shiham I, Mohamed AJ, Ali G, Luna JM, Pandav R, et al. First report of chikungunya from the Maldives. Trans R Soc Trop Med Hyg. 2009;103(2):192-6.
- Sissoko D, Malvy D, Ezzedine K, Renault P, Moscetti F, Ledrans M, et al. Post-epidemic Chikungunya disease on Reunion Island: course of rheumatic manifestations and associated factors over a 15-month period. PLoS Negl Trop Dis. 2009;3(3):e389.
- Pastorino B, Bessaud M, Grandadam M, Murri S, Tolou H, Peyrefitte CN. Development of a TaqMan RT-PCR assay without RNA extraction step for the detection and quantification of African Chikungunya viruses. J Virol Methods. 2005;124(1-2):65-71.
- Pistone T, Ezzedine K, Schuffenecker I, Receveur MC, Malvy D. An imported case of Chikungunya fever from Madagascar: use of the sentinel traveller for detecting emerging arboviral infections in tropical and European countries. Travel Med Infect Dis. 2009;7(1):52-4.
- Acute febrile disease - Maldives: (Laamu Atoll). In: ProMED-mail [online]. Boston US: International Society for Infectious Diseases; 14 January 2009. Archive no. 20090114.0150. Available from: http://www.promedmail.org
- Chikungunya (34): Germany ex Maldives. In: ProMED-mail [online]. Boston US: International Society for Infectious Diseases; 22 September 2009. Archive no. 200900922.3337. Available from: http://www.promedmail.org
- Angelini R, Farinelli AC, Angelini P, Po C, Petropulacos K, Macini P, et al. An outbreak of chikungunya fever in the province of Ravenna, Italy. Euro Surveill. 2007;12(36):pii=3260. Available from: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=3260

domain: medical


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Walk Into The Fire
Songs From the Den
With A Fox: Bio
With A Fox is an Indie Rock project that began in 2016. With their first demo release Rockshow, they acquired Jagger Benham as their bassist, and set out to record their first EP Songs From The Den. The EP was a hit, and finished their members line up with Warren Elder on drums and Ryan Cambridge on guitar. "1000 Nations" became a hit on Ourstage.com, and was voted best of rock for several months in 2017, they also went on to win 98.1 Free FM's Made in London April 2017, which they were awarded $6000.00 for recording. That brought about their next EP Walk Into The Fire, a concept EP featuring 5 new songs.
Before they were able to have their formal release show, the band had to go on hiatus, following an unfortunate health issue that require full attention for most of 2017 and 2018.
2019, Michael and singer Justin Den Bok reconnected, and with health restored, they are resurecting With A Fox! Unfortunately, the hiatus period lead Jaggs, Warren, and Ryan to new projects, and did not have the time to join With A Fox again.
Michael and Justin sought out new members and added Nelle Fuentes on bass & backing vocals, with their friends Chris Demelo on drums and Chris Ma on guitar, With A Fox was back on! Focusing on material to be more cohesive, less eclectic, but still fun, innovative, and hard hitting indie rock.
With A Fox has 2 new songs ready for recording and will set out to lay them down early 2020. Stay tuned!

domain: entertainment


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About Eva´s Brickhouse
Eva´s Brickhouse Restaurant has a new waterfront location! The restaurant was originally located at Bucerias, but now it has a new and beautiful address at the Marina Riviera Nayarit in La Cruz.
The restaurant offers International food, fresh fish and shrimps. They are proud to say they offer freshest seafood in the bay, caught in the morning, comes ashore by noon and served in the afternoon and evenings.
Visit them for breakfast, lunch or dinner. Enjoy the balmy breeze-the beautiful water front view and cuisine to write home about it.
Available for private parties from 20 to 80 persons.

domain: travel


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Mrs. Nadia Alaoui Fettah has been General Manager of Finance & Operations of Saham Finances at Saham Group SA since 2014. Mrs. Fettah served as Deputy Chief Executive Officer of Finance/Mergers and Acquisitions of Saham Group and Deputy Managing Director in charge of operations and finances in Saham Finances SA, Morocco.
In 2000, she founded Maroc Invest Finance Group. She is on the Board of Unitrust Insurance Ltd. She served as Executive Officer of Saham Assurance SA (also known as CNIA SAADA Assurance) and serves as its Representative Director. She is the founder and treasurer of the Club of the Women Board Members in Morocco and a member of the International network of women corporate directors. Prior to joining Saham, she worked with a number of global corporations including Alfen Conseil as Managing Partner and Financial Advisor; CNIA SAADA Insurance as General Manager in charge of Finance and Support Services Division. Ms. Fettah served as Finance and M&A Director of Saham Group since 2013. She began her career in 1992 as a consultant for Arthur Andersen in Casablanca.
In 1997, she joined Axa Insurance Morocco and made the Life & Health Division meet the ISO quality standards. In 2000, she created and she ran Maroc Invest Finance Group, Casablanca, a Moroccan company specialized in investment funds and in corporate finance, which is also a subsidiary of the Turninvest Group. She resumed working for the insurance sector when she joined CNIA in 2005 as the General Director of the Support and Finance Division. She started to work in corporate financial advice in 2010 when she helped Saham Group with operations involving mergers-acquisitions. She served as Chairman of Continental Reinsurance Plc since October 30, 2015 until November 8, 2016 and its Director since September 11, 2015 until November 8, 2016. She is a graduate of Ecole des Haute Etudes Commerciales, Paris, France.
She resigned from her CEO Role before she assumed her role as the Minister of Economy and Finance in the Moroccan government. Since 2019 she has served as the Minister of Tourism, Handicrafts, Air Transport and Social Economy in the Cabinet of Saadeddine Othmani. She was appointed to this post on 7 October 2021.
Mrs. Nadia Alaoui Fettah was named among the Inaugural List of 100 Most Influential African Women in 2019 by Avance Media.
source: avancemedia / wikipedia

domain: economics


My return to blogging experienced a rude shock when I discovered that The Buddy System for Job Seekers had been copied in its entirety on half a dozen other sites.
When I mentioned this to a friend who has sometimes earned her living as a writer, she immediately responded that it would almost be a compliment, if it wasn’t plagiarism.
Indeed, it was a little creepy.
My first clue came when WordPress’s Dashboard informed me of a “pingback.” After seeing two blogs that had lifted my entire post, I did a Google search and turned up more.
They were amazingly efficient, if flagrant in their disregard for the effort I put into writing. They simply copied my entire post to their sites and adding a few tags (of which more later). A quick look at some of the sites made me suspect that all their posts were like that: copied directly from another blog. There was no rhyme nor reason to the topics of these posts, no consistency in writing style. And, yes, there were these weird tags added, which had nothing to do with my post—or, that I could see, with the other posts.
I mean, NASCAR?? Not only did my post have nothing to do with NASCAR, I don’t even know how to drive!
After sputting indignantly to myself for a few minutes, I did a little research. Three of the plagiarized posts were on Blogger (owned by Google) and two on Typepad. I poked around their main websites to find contact information to report the plagiarism. It wasn’t particularly difficult; I merely provided the URLs of the offending posts and the URL to my original post.
To their credit, both Typepad and Google removed the posts and notified me in less than 48 hours. Google removed my posts from the offending blogs. Typepad went further and deleted the entire blog. (That’s no small thing because Typepad blogs—unlike Blogger and WordPress.com—are not free.)
Which leads me to the bigger question: Why steal my post? I happen to think I’m a pretty good writer, but I’m not that good. (Am I?) And I’m not a big name. Circle of Ignorance is my personal blog, not some top-ranked site.
As far as I could tell—although I didn’t linger; it felt like being in a dirty restroom in a dive bar in a bad neighborhood late at night—the plagiarizing sites werern’t selling anything. They weren’t likely to make money by publishing (in this case stealing) my post. And none of them seemed to have big audience: neither my post nor any of the others I looked at had received any comments.
So I am left scratching my head. Steal my post, tag it with completely unrelated tags, don’t try to make money. Violate Terms of Service (not to mention copyright laws) and get taken down. Yeah, that’s a plan.
So for my sins I have a new temp gig… researching copyright permissions for a publisher. I’m up to my ears in copyright notices, requesting permissions where needed, and learning more about the subject than I ever expected. But, darn, I believe in copyright—and also in “fair use.” Writers, musicians and artists are entitled to ownership of their work. People should be able to read, listen to or view it, and to share limited quotes for reasonable purposes, but that doesn’t extend to lifting someone’s whole blog post, article or chapter without even asking. And without even a discernable motive.
PS: If you’d like to quote a couple of sentence, fine. Give me credit and link back to my post. Keep it relevant and polite, and don’t try to make a buck off it because I don’t. I’ll be thinking about this a good deal and you’ll see more thoughts on copyright, fair use, open source, and Creative Commons in future posts.


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- About Us
- Pharm.D (PB)
- PG Diploma
- Anti Ragging Committee
- Grievance Redressal Committee
- Institutional Animals Ethics Committee
- Institutional Human Ethics Committee
- Institutional Research Advisory Committee
- Sexual Harassment Cell
- Institutional Pharmaceutical Society
- Class Representatives
- Institutional Library Committee
- Student Lady Representatives
Name: Mrs. J. C. Thejaswini
Present Designation: Assistant Professor
Department: Pharmaceutical Chemistry
Mobile : +91 9916577224
Mail ID : firstname.lastname@example.org
|2010||PhD in Pharmaceutical Chemistry||JSS University||Ongoing|
University of Health Sciences, Bangalore
|1996||B. Pharm||Rajiv Gandhi University of Health Sciences, Bangalore||First|
Highest qualification: M. Pharm
Area of interest:
- Bioanalytical method development and validation
- Analytical method development for drugs
- Drug interaction assessment
||to till date||Assistant Professor,
JSS College of Pharmacy, Mysore.
|2 Years and 10 Months|
JSS College of Pharmacy, Mysore.
|Under Graduate||Post Graduate|
Instrumental methods of analysis
|-||Food and cosmetic analysis|
|Pharmaceutical inorganic chemistry||-||-|
Conference/ seminar attended
(01 completed, 3 ongoing)
Member of professional bodies
|Name of the Professional body||Registration No.||Registration Date|
|Karnataka State Pharmacy Council||43544||17-05-2010|
National Publications: 01
- Soujanya K, Thejaswini JC, Gurupadayya BM and Raja P. Quantitative determination of pregabalin by gas chromatography using ethyl chloroformate as derivatizing reagent in Pure and Pharmaceutical preparation. Indian Drugs. 2011; 48(03): 43-47.
International Publications: 07
- Jayashree BS, Thejaswini JC, Yogendra Nayak and Vijay kumar D. Synthesis of novel flavones acyl esters and correlation of log P value with antioxidant and anti microbial activity. Asian J chemistry. 2010; 22 (2):1051-1054.
- Aswani Kumar CH, Gurupadayya BM, Navya Sloka S, Chandan RS and Thejaswini JC. Spectrophotometric Determination of Certain Cephalosporins Using 1, 2-Napthaquinone-4-sulfonic acid Sodium in Pharmaceutical Dosage Form. Tropical J Pharmaceutical Research. 2011; 10 (1): 81-88.
- Sowjanya K, Thejaswini JC, Gurupadayya BM and Indu priya M. Spectrophotometric determination of Pregabalin using 1, 2-Napthaquinone-4-sulfonic acid Sodium and 2, 4 dinitrophenyl hydrazine in pharmaceutical dosage form. Der Pharmacia Lettre. 2011; 3(2): 47-56.
- Soujanya K, Thejaswini JC and Gurupadayya BM. Spectrophotometric Determination of Pregabalin Using Gibb’s and MBTH reagent in Pharmaceutical Dosage Form". Der Pharma Chemica. 2011; 3(1): 112-122.
- P. Raja, Thejaswini JC, Gurupadayya BM, Sowjanya K. Determination and Validation of Metformin, Glimepiride, Pioglitazone Using Atorvastatin as an Internal Standard in Bulk Drug and Pharmaceutical Dosage Form. J Applied Chemical Research. 2011; 18: 61-68.
- Pamuru Raja, Thejaswini JC, Gurupadayya BM and Jagadeeswara Reddy D. Stability indicating RP-HPLC method for simultaneous, determination of anti diabetic drugs. J Pharmacy Research. 2011; 4(5): 1791-1794.
- Thejaswini J. C.*, Gurupadayya B. M. and Ranjith Kumar K, Quantitative determination of duloxetine hcl in human plasma by GC-FID method, International Journal of Pharmacy and Pharmaceutical Sciences, 2013 5(2), 405-408.
|1. One-day seminar on “Scientific Writing and Publication” at JSS University, Mysore, on 2nd December 2009.||1. Indo-US Symposium On Frontiers In Medicinal Chemistry And Drug Discovery, on 21nd - 23rd April 2011 at JSS Medical College, Mysore|
||2. 3rd International Conference and Exhibition on Analytical & Bioanalytical Techniques on at Hyderabad November 22-24, 2012|
||3. International Conference on Health Sciences, Mysore, 25th and 26th February 2005.|
Presentation at conference/seminars
|Name of the conference/ seminar and place||Dates||Title of paper presented/Section||Author/s|
|1. Indo-US Symposium On Frontiers In Medicinal Chemistry And Drug Discovery, at JSS Medical College, Mysore||21st - 23rd April, 2011||Quantitative determination of Pregabalin by RP-HPLC and GC-FID||J. C. Thejaswini, B. M. Gurupadayya and P. Raja|
|. 3rd International Conference and Exhibition on Analytical & Bioanalytical Techniques on at Hyderabad||November 22nd -24th , 2012||Simultaneous determination of Amitriptyline, carbamazepine and flunnarizine in human plasma by RP-HPLC method||J. C. Thejaswini and B. M. Gurupadayya|
Awards and Achievements:
- Best poster award for article titled Quantitative determination of Pregabalin by RP-HPLC and GC-FID, during Indo-US Symposium On Frontiers In Medicinal Chemistry And Drug Discovery, on 21nd - 23rd April 2011 at JSS Medical College, Mysore.
|Title of the project||Sponsoring agency||Investigator/s||Cost
|Year of start||Duration||Status|
|Drug Interaction Assessment and TDM of Drugs Acting on CNS||VGST under SMYSR scheme 2012-13||J. C. Thejaswini||5.0||2012-13||1 Year||Ongoing|
|Bio-analytical Liquid Chromatographic Determination of Some Selected Chiral Drugs in Pharmaceutical Dosage Forms||UGC-MRP||Co-Investigator
J. C. Thejaswini
|7.7 lakhs||2013||3 years 2013-15||Ongoing|
|Academic year||Name of the student||Dissertation Title|
|2009-10||E. Venkataramaiah||Development and validation of analytical methods for the estimation of medicinal compounds having hydroxyl group|
|2009-10||P. Raja||Evaluation of influence of herbal antidiabetics on oral antidiabetic drugs|
|2009-10||Soujanya K||Analytical method development and validation for quantitative estimation of drugs acting on central nervous system|
|2010-11||M. Prudhvi Raju||Analytical method development for the quantitative determination of steroids in herbal formulations|
|2010-11||Ragaleena V||Simultaneous estimation of formulations containing NSAIDS.|
|2010-11||Ramdilip||Development and validation of rapid and sensitive analytical methods for cleaning validation using swab sampling|
|2011-12||K. Kinnera||Bio analytical Method development and validation for determination of pramipexole dihydrochloride and levodopa|
|2011-12||Ranjith Kumar||Development and validation of RP-HPLC method for simultaneous determination of Amlodipine Besylate, Olmesartan Medoxomil and Hydrochlorthiazide in tabletdosage form and its stability indicating assay|
|2011-12||Arathy devi||Analytical method development for the estimation of polyvinyl alcohol and polyvinyl pyrrolidone in ophthalmics by UV – Visible spectroscopy and RP-HPLC|


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The Booth at the End Season One Review
This shift is most signified by two dramatic web series creations that both premiered in 2011. The Kiefer Sutherland/John Hurt web series The Confession, for instance, is a Plato-style “dialogue” that debates such philosophical questions as the nature of good and evil, free-will versus destiny and the inherent qualities of human beings. The Booth at the End, meanwhile, likewise serves as a dissertation on mankind while exploring the concept of morality, how far one is willing to go to achieve their goals and the psychological consequences of our actions. Taken together, these two endeavors demonstrate the growing dramatic potential of the medium.
The concept and structure of The Booth at the End is relatively simple—a nameless and mysterious man sits in a booth at the back of a diner and assigns certain tasks to individuals in exchange for having their wishes granted. One by one, ordinary people looking for solutions to life’s trials and tribulations approach “The Man” (portrayed by veteran actor Xander Berkeley) are given their assignments and then later report on their progress. In this sense, The Booth at the End is tailor made for the technology of today in that it can be viewed as a series of sixty-two short installments via mobile phones, as five twenty-two minute episodes on Hulu or even the eventual possibility of one full-length motion picture.
While the narrative device of numerous short scenes all taking place in one locale may initially appear monotonous, the feeling quickly switches to curiosity, intrigue and anticipation. Like any good form of entertainment—whether theater, film or television—The Booth at the End realizes that it’s ultimately the story and characters that matter more than flash and style. That is not to say that the production does not have solid technical qualities, because it does. Produced by the Michael Eisner-owned Vuguru, The Booth at the End is a true cinematic achievement within the web series medium. It’s just that while its style may be subtle and setting rather simplistic, the narrative itself is what truly grabs the viewer and draws them into the world that The Booth at the End has created.
How far will a man go to save his dying child? To what extreme will an elderly woman venture to rescue her husband from the grasp of Alzheimer’s? What will a person do to reconcile with his estranged son? These are just a few of the questions that The Booth at the End asks, and “The Man” of the series appears just as curious about the answers as anyone. The tasks he assigns go beyond right and wrong, and include killing an innocent girl, setting off a homemade bomb in a busy coffee shop and stealing in excess of $100,000 from a bank. Although the “will they or won’t they” question hangs in the air throughout the web series, the reactions of the individuals to their assignments and how they handle the moral dilemmas are just as intriguing as the outcomes.
The Booth at the End wisely intertwines many of the individual storylines involving the various characters, giving the web series a more seamless and fluid flow. While “The Man” allocates one person the task of killing a little girl, for instance, the assignment of another is to protect the girl in question. Then there is the issue of “The Man” himself, as he does not make empty promises—once a task is completed, the requested wish is granted in a natural and synchronistic fashion. But is it supernatural, or simply a form of extreme coincidence?
More importantly, who is “The Man”? One client asks, “How can I know you’re not the devil?” and the response is, “You can’t.” When asked if he believes in God, “The Man” replies, “I believe in the details.” Later in the narrative, he hints that he is merely a go-between, a middle-man if you will, who simply assigns the tasks from a leather-bound book he keeps by his side and continuously uses to record the outcomes. And although his neutrality in regards to whether an assignment is actually carried out or not is evident, “The Man” often appears both surprised and relieved when someone refuses to follow through on their assignment, while likewise showing disappointment when they do.
“I try to engage online with people because I think that’s part of the world we live in now,” creator Christopher Kubasik explained to Blogcritics in August 2011. “And so I was watching the arguments and discussions, with all these theories about who ‘The Man’ is and how it works. ‘He’s not magic; he is magic. He’s God; he’s the Devil. He’s a therapist with extreme measures.’ All these great things were being floated, and my manager reminded me that I said years ago when I was working on The Booth, I said ‘the Internet is for arguing, and I want a show that will create arguments.’ So the ambiguity about ‘The Man,’ and the book, and who he is, and how he relates to the other characters. I wanted to leave a lot of room for the audience to play.”
The Booth at the End does indeed provide a lot of room to play, as well as plenty to digest, debate and keep one on the edge of their seat while waiting for the next installment. The set-up may appear simplistic, but its execution is flawless and reflects the old adage that it’s the story that matters. The Booth at the End also demonstrates that the web series medium is no longer a novelty, but a creative force to finally be reckoned with—a task that a few years ago seemed just as difficult to complete as the assignments handed out by “The Man” himself.
Anthony Letizia (September 5, 2011)


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Yesterday morning Tomorrowland hosted an intimate gathering in De Schorre, Belgium. The purpose of the event was to launch One World Radio, the festival's new radio broadcast. Standing in the centre of the newly expanded main stage area with the Tomorrowland hot air balloon as a backdrop, Steve Aoki played a fifteen-minute set in honour of 15 years of Tomorrowland.
Every year thousands of people flock to Boom, Belgium to experience one of the world’s premiere electronic Dance Music festivals. Tomorrowland brings in some of the biggest names, biggest crowds, and provides one of the most exquisite experiences around. Built on the De Shorre park, it is receiving some exciting updates. Collaborating with the province of Antwerp, The provinces home De


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Son of Thunder. Book 2 of the Esther Brookstone Art Detective Series. Esther Brookstone is at it again, this time obsessing about the life and times of St. John the Divine, all triggered by the discovery of a parchment hidden in the frame of a Botticelli painting that she authenticates. As in Rembrandt’s Angel, she soon gets into trouble, and her paramour, Interpol agent Bastiann van Coevorden, again comes to her aid. A race to find the saint’s tomb results, because Esther has competition. Three centuries of action involving the saint, the Renaissance artist Sandro Botticelli, and Esther and Bastiann, make this sequel a book of mystery, thrills, and suspense that will keep readers guessing.
“A deftly crafted and consistently riveting read from beginning to end. Rembrandt’s Angel showcases author Steven Moore’s genuine flair for originality and his impressive mastery of the Mystery/Suspense genre.” — Midwest Book Review for Rembrandt’s Angel


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birds eye california blend recipes
Ingredient Checklist 1 (16 ounce) package frozen broccoli, carrots and cauliflower combination 1 (10.75 ounce) can condensed cream of mushroom soup Now dinner’s complete with Birds Eye. The combination of broccoli, cauliflower, and carrots are perfectly paired. See more ideas about recipes, food, vegetable recipes. When they are coated bake vegetables for 20 minutes or until tender. They cook right in the bag. Want to share your own special recipe? Contains no artificial preservatives or flavors ; Good source of vitamin C ; Excellent source of vitamin A Have your own special recipe to share? Flavor Full veggies are an easy way to help your family eat better. soy sauce 1/2 c. butter/margarine 1 tsp. Feb 19, 2016 - Food prepared with pre-preped vegetables and rice from Birds Eye Brand. 1 bag Birds-eye California Blend Veg., cooked in microwave 1/2 tbsp. They’re frozen, so you can carry them to work and microwave for lunch. Corn shares the spotlight with chicken in this well-seasoned soup. These delicious sides need no recipes. Steamed vegetables sometimes lack distinguished flavors and roasting veggies in spices just makes them tender and crispy all at the same time. Use a bag of frozen or farmers market fresh vegetables but no matter what the taste will be exactly what youâre looking for. fresh mushrooms) 1 lb. Blending part of the corn with the broth is a really simple and easy way to thicken up the soup and boost the flavor. Preheat oven to 425 degrees. Steamfresh Protein Blends are complete sides that are ready in minutes. Submit Your Recipe Today! Get a wealth of delicious recipes for every meal using Birds Eye vegetables. Instructions. Food prepared with pre-preped vegetables and rice from Birds Eye Brand. chopped garlic 1 can mushrooms (or 8oz. Place the vegetables onto a baking sheet lined with parchment paper and drizzle oil and spices over them. Herb-Roasted Vegetables Recipe: How to Make It | Taste of Home Look for Ranch Broccoli, Barbecue Sweet Corn, Buffalo Cauliflower, and Teriyaki Broccoli at your grocery. It's good to eat vegetables, so we make vegetables good to eat. Very low in calories & absolutely delicious! Grease a 13×9″ baking pan with nonstick spray. Whip up a delectable and filling meal with this savory…, Breakfast can't just be a bowl of cereals, sometimes we…, Add a bit of spice to your usual vegetable soup.…, Please log in or register to leave a comment, Roasted California Blend Vegetables Recipe. With Birds Eye ® deluxe vegetables, you can enjoy a California Blend with broccoli, cauliflower, and carrots for the whole family. When they are coated bake vegetables for 20 minutes or until tender. It is so easy to add Birds Eye Flavor Full Veggies into a busy lifestyle. Sometimes you need a quick and easy source of protein. Steamfresh packaging makes preparing these nutritious & delicious vegetables a breeze. cooked cubed chicken, beef or pork Simply register with us and start sharing! Serve hot! Place the vegetables onto a baking sheet lined with parchment paper and drizzle oil and spices over them. Find your favorite style at your local grocery store. In a large bowl mix the onions, butter, mayo, sour cream, salt and garlic pepper. Scrambled Eggs in Baby Brioches with Smoked Salmon and Asparagus, Copycat Noodles & Co. Japanese Pan Noodles Recipe, Copycat Trader Joeâs Veggie Masala Burgers Recipe. Get fast, easy, flavorful, and healthy veggie-forward recipe options. Preheat oven to 400 degrees. Asian Peas, Tenderstem Broccolli and Tofu Salad with Black Sesame Seeds & Lime Dressing Austrian Fish Finger Sandwich BBQ Beef Burger Recipe BBQ Cheeseburger Recipe BBQ Chicken Dipper Nachos BBQ Sauce Bacon and Cheese Burger Baked Cheesy Dippers with Nacho Cheese Cheddar Basil Pea Pesto and Sundried Tomato with Gnocchi Battered Coated Fish, Potato Wedges and Remoulade … The secret to getting dinner on the table in 20 minutes is picking up the right ingredients from the grocery store.
Whirlpool Wrs315sdhz Manual, Aluminum Foil On Pizza Stone, Metal Solubility Vs Ph, Guitar Scale Positions Pdf, Redken Color Extend Shampoo And Conditioner Set, Rotel Original Vs Fire Roasted, Checking Out Me History Essay, Kicker Cvr 12'' 2 Ohm, Tetris Effect Original Soundtrack Flac, Tasco Luminova 660x60mm Refractor Telescope, Jumbo Buffalo Wings Calories, London Pilsner Beer Review, Presto Professional Eversharp Electric Knife Sharpener Manual,
12th November 2018

domain: food


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Lightbot Programming Puzzles 1.6.0 Apk
Lightbot Programming Puzzles v1.6.0 Apk
Requirements: 2.3 +
Get youngsters addicteded to programming within mins.
Lightbot is a shows puzzle game: a puzzle video game that uses video game technicians that are firmly rooted in shows ideas.
Lightbot lets gamers get a practical understanding of fundamental control-flow ideas like treatments, loopholes, as well as conditionals, merely by directing a robot with commands to illuminate tiles as well as fix levels. Ideal for ages 8+.
Teachers and parents worldwide are choosing Lightbot initially out of various other video games and also software application when presenting kids to programming.
Lightbot attributes 50 degrees as well as 20 challenge stars to gather as well as is an essential for puzzle enthusiasts of any kind of age.
This version of Lightbot lets you play in English, French, Russian, Brazilian Portuguese, Spanish, Traditional and Simplified Chinese, Norwegian, Slovenian, Romanian, Indonesian, German or Polish! Merely attack a flag icon corresponding to the language in the video game!
Exactly what’s New
- NEW to Google Play: Lightbot now includes numerous save slots and also the ability to track progression across several gamers.
- Now several players could take pleasure in Lightbot within their own save slot, progressing at their own pace, and contending on number of levels completed, number of superstars accumulated and also complete number of commands made use of once all levels are comprehensive (Lower rating = far better).
- New languages Japanese, Oriental, Thai, Malay, Hindi & Swedish included!
- And as consistently, thanks for supporting Lightbot.
This application has no ads.
Download Lightbot Programming Puzzles v1.6.0 Apk


So I have no grounds to attack him or criticize him for anything, or protect him or whatever Putin said.
Officials have not confirmed the details of the dossier, but they have told CBS News they believe Russia may well have collected what is known as kompromat.
Because the information is so sensitive, the addendum was not part of the classified report that was distributed to a wider group of people last week.
Those anti-Trump forces in the US also want to " bind hand and foot " the newly-elected leader, Putin added.Election contained unverified details of potentially compromising information that Russia has gathered.The Russian leader said Tuesday he hoped.Read more: Theresa May says Trump dossier spy Christopher Steele hasnt worked for UK for years.Intelligence community - for hacking Democratic institutions and interfering in the American presidential election process in favor.Intelligence is in the process of corroborating the details of what the Russians may have, but the officials told CBS News that the former British investigator and his prostitution trafficking and exploitation network are considered credible.The US president-elect, who will be inaugurated on sex tonight January 20, has branded the dossier a " complete fraud saying that intelligence insiders have confirmed to him that the allegations were fake.The Kremlin has dismissed the claims of compromising material.Russias President Vladimir Putin on Tuesday brushed aside accusations in a recent discredited report that President-elect Donald Trump had once cavorted with prostitutes in Moscow.The campaign to discredit the president-elect shows that certain " political elites in the West, including in the US have " significantly " worsened, according to the Russian president.Trump angrily denied the claims in a press conference last week, and most media organizations cast doubt on their credibility. .
Trump as a fabrication and utter nonsense.
By doing so, these forces " severely harm US interests Putin said.
Westlaw, build the strongest argument relying on authoritative content, attorney-editor expertise, and industry defining technology.
Trump is a grown man, Putin said, according.
Of course not, it's complete rubbish, " Putin said.
Reuters, he dismissed as a hoax a privately-prepared intelligence dossier that claimed Russian intelligence agencies had compromising material.
His new book, How Trump Won: The Inside Story of a Revolution, is available from Regnery.Follow him on Twitter at @joelpollak." i have an impression they practiced in Kiev and are ready to organize a Maidan in Washington, just to not let Trump take office Putin said, apparently referring to anti-government protests in the Ukrainian capital in 2014, which resulted in the leadership being ousted.Among the more salacious accusations was that Trump had hired several prostitutes to urinate on a bed in a Moscow hotel room where President Barack Obama and First Lady Michelle Obama had once spent the night.We didn't even know about his political ambitions, he was just a businessman, one of America's richest people.President-elect Donald Trump are worse than prostitutes.Trumps presidency would allow for the normalization.S.-Russian relations.Multiple government and intelligence officials told CBS News a week ago that an addendum to the classified intelligence report on Russias efforts to interfere in the.S.Pollak is Senior Editor-at-Large at Breitbart News.
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text:
(22)-6b-methoxy-3a,5-cyclo-5a-cholestan-24-one-22-ol as an intermediate in the synthesis of (22r,23r)-3b-acetoxy-22,23 - isopropylidenedioxy-24-metalholic-5-ene
(57) Abstract:Use: as an intermediate product in the synthesis of rototiller plants - brassinolide). The inventive product (22 x )-6 b-methoxy-3 a , 5-cyclo-5 a-cholestan-24-one-22-ol, yield 90%. BF C28H47O3. Reagent 1: (22 )-6 b-methoxy-3 a , 5-cyclo-5 a-pregnan-20-formyl. Reagent 2: methyltriphenylphosphonium in the presence of utility and isobutyronitrile. Reagent 3: hydrogen gas on the Raney Nickel in the presence of boric acid. Output increased 2.5 times since the simplified schema of the target product. The invention relates to new chemical compound, specifically to (22 )-6-methoxy-3,5-cyclo-5-cholestan-24-one-22-Olu formula I,
which is an intermediate substance to obtain (22R, 23R)-3 - acetoxy-22,23-isopropylidenedioxy-24-metalholic-5 - ene of formula II;
Compound II is a well-known synthetic precursor hormone brassinolide) III, which is found in very low concentrations in some plants and is the most active of the new class of natural hormones - steroids, and therefore can be used in agriculture as a growth promoter, plant /1/. His synthesis of the methoxy-24-methyl - 5-cholestan-22,23,26-triol (IV):
It is obtained from (20S)-6-methoxy-20-formyl-3 , 5-cyclo-5-pregnane (V) in seven stages with the release of 21% in the General scheme /3/:
____< / BR>____ ____< / BR>IVAttach 2-liliputana to (20S)-22-aldehyde (V) receive fullcarbon in the form of a mixture of two isomers (VI) and (VII), one of which (VI) after chromatographic separation oxidized with N-bromosuccinimide and get lactol (VIII) as a mixture of two isomers, which is then transformed into a mix - and-ethoxyethyl esters (IX) and (X) with the release of 96% in the ratio of 3:1. Main isomer (IX), the selected chromatographic process lithium dimethylcarbinol, and the resulting ketone (XI) is subjected to the action of sitedisability and under the conditions that leads to bis-methylated product (XII) with a yield of 84%. The restoration of the keto group of compound (XII) detribalized get the alcohol (XII) with a yield of 92%, the treatment of which 10% HCl and subsequent recovery of lithium aluminum hydride leads to the desired triol (IV) yield 81%.The use of triol (IV) to obtain the compound (II) includes the following stages:
< / BR>_____ The compound (IV) is heated in acetic acid and obtain the corresponding 3-acetoxy-5-ene (96%), which after processing p-toluensulfonate in acetone leads to and is cholest-5-ene (II) sequential processing methanesulfonamido in pyridine, recovering the resulting ester with lithium aluminum hydride and acetylation with a total yield of 80%.The total number of stages in obtaining predecessor brassinolide) (II) under the scheme of the aldehyde (V) is equal to 9, with a total yield of about 12%.The disadvantage of using triol (IV) as an intermediate product to obtain the compound (II) is a multi-stage process, its complexity, and not a high yield.The aim of the invention is to simplify the process of obtaining (22R,23R)-3-acetoxy-22,23-isopropylidenedioxy-24-IU-TileList-5-ene (II) of the aldehyde (V) and the reduction in the number of stages.This goal is achieved by the described compound (22 )-6-methoxy-3 , 5-cyclo-5-cholestan-24-one-22-I (I). The described compound (I) is obtained from the 20-aldehyde (V) in two stages according to the scheme:
< / BR>The aldehyde (V) is subjected to the action of the Wittig reagent and the resulting steroid olefin by 1,3-dipolar cycloaddition of isobutyronitrile turn in isoxazolin (XV) c output 90% recovery splitting on the Raney Nickel transform in the inventive connection-within (I) with the release of 95%.It should be noted that the inventive compound (I) is used on the aspects of chromatographic separation epimeres. The transformation of the claimed compound (I) in the well-known synthetic precursor of brassinolide) (II) is carried out according to the scheme:
II-Within (I) the alkylate methyllithium, the resulting secondary alcohol is oxidized by the reagent Carreta (CrO3.Py) and dehydration by treatment with p-TsOH. Get inceton (XVI) with a total yield of 80% . Restoring eketone (XVI) diisobutylaluminium, epoxidation m-chloramben - sainoi acid and disclosure of epoxide aluminum hydride leads to diolo (XVII) with a yield of 60%. Last by boiling in acetic acid and treatment p-toluensulfonate in acetone converted into the target compound (II) with a yield of 90% . Thus, (22R,23R)-3-acetoxy-22,23-isopropylidenedioxy-24-metalholic-5-ene (II) receive from the aldehyde (V) under this scheme using the described compounds (I) in 5 stages with the release of 37%.P R I m e R 1. Obtaining (22)-6-methoxy-3 ,5-cyclo-5-cholestan-24-one-22-ol.To the suspension to 13.09 g (36.6 mmol) of methyltriphenylphosphonium in dry ether (150 ml) is added in an argon atmosphere at room temperature of 14.8 ml of a 2.25 M solution of utility. Stirred for 2 h and add 11,47 g (33.3 mmol) of the 20-aldehyde (V) in dry THF. The mixture is boiled for 5 hours Then filtered, dried over Na2SO4, the sid, obtained from 8,96 g (66,6 mmol) N-chlorosuccinimide in 300 ml of chloroform, to 0.12 ml of pyridine and 5,78 g (66,6 mmol) of oxime samalanga aldehyde. After a few minutes add 7,12 g (a 56.6 mmol) of triethylamine in chloroform for 6 hours, the Reaction mixture was stirred at room temperature for 24 h and the solvent evaporated. The residue is treated with water and extracted with ether. The ether solution is passed through a filter with alumina, the solvent is evaporated. Received 12,78 g (90%) of (20S,5' )-20-(3'-isopropylthiazole-5-yl)-6-meth - oxy-3 ,5-cyclo-5-pregnane (XV).PMR-spectrum (200 MHz, M. D.): 0,42 m (1H, cyclop.), 0.65 m (1H, Cyclops. ), of 0.71 (3H,18-Me), of 0.87 (3H, J = 7 Hz, 21-Me), a 1.01 (3H, 19-Me), 1,15 d (6N, J = 7 Hz, 26-and 27-IU), 2,63 DD (1H, J1= 16 Hz, J2=8 Hz, C23-N), 2,71 Sept. (1H, J = 7 Hz, C25-N), 2,78 m (1H, C6-N), 2,94 DD (1H, J1= 16 Hz, J2= 11 Hz, C23-N) to 3.33 (3H, OMe), 4,67 m (1H, C22-H); IR spectrum (film, cm-1): 1620, 1100.Mass spectrum (m/z): 427 /M/+, 412/M-Me)+, 395/M-MeOH)+, 372.To a well stirred in ethyl alcohol the Raney Nickel type of 18.6 g (300 mmol) of boric acid and 12,35 g (29 mmol) of isoxazoline (XV). The reaction mixture was kept at room temperature and stirring in an atmosphere of hydrogen for 7 hours Then provide water and dried over Na2SO4. The solvent is evaporated to 2/3 of its volume and the residue is passed through a filter with silica gel. After evaporation of the solvent receive 11,84 g (95% ) (22 )-6-methoxy-3 ,5-cyclo-5-cholestan-24-one-22-ol (I). PMR-spectrum (200 MHz , M. D.): 0,44 m (1H, cyclop.), 0.65 M (1H, cyclop.), to 0.74 (3H, 18-Me), 0.95 (3H, J = =7 Hz, 21-Me), of 1.02 (3H, 19-Me), 1,11 d (6N, J = 7 Hz, 26-and 27-IU), 2,41 DD (1H, J1= 17 Hz, J2= 10 Hz, C23-N), 2,54 DD (1H, J1= 17 Hz, J2= 3 Hz, C23-H), 2.63 in Sept. (1H, J = 7 Hz, C23-N), 2,78 m (1H, C6-N) to 3.33 (3H, OMe), 4.10 m (1H, C22-N).IR spectrum (film, cm-1): 3510, 1710, 1100.Mass spectrum (m/z) 430/M/+, 415/M-Me/+,398/M-MeOH/+, 397/M-Me-H2O/+, 375, 329.P R I m m e R 2. Receipt of (22R,23R)- 3-acetoxy-22,23-isopropylidenedioxy - 24-metalholic-5-ene (II).To a solution of br11.01 g (25.5 mmol) is within (I) in 350 ml of absolute ether in an argon atmosphere is added dropwise 150 ml of 1.0 N. the ether solution metallice, maintaining a temperature of 0-5aboutC. Stirred the reaction mixture for 2 hours and add ammonium chloride, water, and extracted with ether. Dried over Na2SO4, evaporated, the residue is dissolved in 145 ml of methylene chloride and add 1.2 g of reagent Carreta. The solution was stirred at room temperature and evaporated. The residue is dissolved in 300 ml of anhydrous benzene, add a catalytic amount of para-toluenesulfonic acid and calcium chloride. The reaction mixture is heated to boiling and boil for 5-10 minutes Then the reaction mixture is cooled and passed through a layer of aluminum oxide evaporated. Get 8,67 g (80% ) 24-methyl-6-methoxy-3 ,5-cyclo-5-cholesterol-23-ene-22-she (XVI). IR spectrum (KBr, cm-1): 1680, 1620, 1040.Mass spectrum (m/z): 426/M/+, 384/M-MeOH/+.PMR-spectrum (200, MHz , M. D.): 0,44 m and 0.65 m (2N, cyclop.), 0,70 (3H, 18-Me), of 1.02 (3H, 19-Me), 1.07 (6N, J = 7 Hz, 26-and 27-IU), 1,11 d (3H, J = 7 Hz, 21-Me), 2,08 D. (3H, J = =1.5 Hz, 28-Me), to 3.33 (3H, OMe), 6,06 Shire. (1H, C23-N).To mix the solution 5,112 g (0.012 mol) of the ketone (XVI) in 50 ml of THF in a stream of argon add 38 g of 86% of DIBAH in THF at -78aboutC. the Reaction mixture is stirred for 30 min and gently poured upon cooling in an ice bath in a mixture of methanol and petroleum ether. The resulting suspension is stirred for 1 h, evaporated the solvent, add 200 ml of water and extracted with methylene chloride, washed with a solution of NH4Cl and NaHCO3, dried over Na2SO4. To the resulting solution was poured a solution of 2.40 g (0.014 mol) of meta-chlormadinone acid in 25 ml of methylene chloride. The reaction dare and filtered through a layer of aluminum oxide. The solvent is evaporated. The residue is dissolved in ether and poured to aluminum hydride prepared from 0.34 g LiAlH4and 0.31 AlCl3in ether at room temperature. Stirred for 1 h and treated with 150 ml of 50% AcOH, extracted with ethyl acetate, the extracts washed with a solution of NaHCO3, water, dried over Na2SO4, evaporated. The residue is subjected to column chromatography on silica gel (eluent-hexane-ether). Get 3,21 g (60%) of (22R,23R,24S)-22,23-dihydroxy-24-methyl-6-methoxy-3 ,5-cyclo-5-cholestan (XVII).PMR-spectrum (200 MHz , M. D.): 0,82 (3H, 18-Me), was 1.04 (3H, 21-Me), was 1.06 (3H, 19-Me), 1,11 d (3H, 28-Me), 1.16 and 1.20 of, 2 d (6N, 27 and 28 IU), 2,78 m (1H, 6-H), 3.33 and m (3H, OMe), 4,91-5,41 (2H, 22-H and 23-H).IR spectrum (film, cm-1): 3450. Mass spectrum (m/z): 446/M/+, 431/M-Me/+, 414/M-MeOH/+.2.37 g (5 mmol) of diol (XVII) is dissolved in 50 ml of acetic acid and boiled for 0.5 hours After cooling, the reaction mixture was poured into sodium hydrogen carbonate solution and extracted with ether, washed with water, dried over Na2SO4and evaporated. The residue is dissolved in acetone (50 ml), add a few crystals of p-toluene - sulfonic acids and boil for 2 hours, the Reaction mixture was poured into a solution of potassium carbonate and extracted with ether, dried over Na2SO4IR spectrum (KBr, cm-1): 1735, 1250.PMR-spectrum (200 MHz , M. D.): 0,80 (3H, 18-Me), of 1.03 (3H, 21-Me), was 1.06 (3H, 19-Me), 1.13 (3H, 28-Me), 1,17 l and 1.29 d (6N, 26 and 27 IU), 1,34 with and 1.52m (6N, IU-acetone. protection), 3,90 was 4.42 (2H, 22-H and 23-H), 4.59 (1H, 3-H), 5,38 m (1H, 6-H).Mass spectrum (m/z): 514/M/+, 454/M-AcOH/+.Thus, the use of the inventive substances (1) as an intermediate of synthesis of (22R, 23R)-3-acetoxy-22,23 - isopropylidenedioxy-24-metalholic-5-ene (II) of the aldehyde (V) allows platitudinal the transition to the target product, which is stage 4 less, compared with the scheme using analog (IV) to increase output by 2.5 times and to simplify the scheme, excluding the hard work of separating mixtures of epimeres in some cases. (22 )-6-methoxy-3 ,5-cyclo-5-cholestan-24-one-22-ol of the formula
< / BR>as an intermediate in the synthesis of (22R,23R)- 3-acetoxy-22,23-isopropylidenedioxy-24-metalholic-5-ene.
cholesterol (Chs)< / BR>testosterone (TS)which can be used as source reagents for solid-phase synthesis of steroid derivatives of oligonucleotides and their analogues
FIELD: organic chemistry, steroids, medicine, pharmacy.
SUBSTANCE: invention relates to 3-methylene-steroid derivative of the general formula (1):
wherein R1 means hydrogen atom (H), or in common with R3 it forms β-epoxide; or R1 is absent in the presence of 5-10-double bond; R2 means (C1-C5)-alkyl; R3 means βH, βCH3 or in common with R1 it forms β-epoxide; either R3 is absent in the presence of 5-10-double bond; R4 means hydrogen atom, lower alkyl; Y represents [H, H], [OH, H], [OH, (C2-C5)-alkenyl], [OH, (C2-C5)-alkynyl] or (C1-C6)-alkylidene, or =NOR5 wherein R5 means hydrogen atom (H), lower alkyl; dotted lines represent optional double bond. Compound can relate also to its prodrug used for treatment of arthritis and/or autoimmune diseases.
EFFECT: valuable medicinal properties of compounds, improved method for treatment.
38 cl, 1 tbl, 18 ex
FIELD: organic chemistry, medicine, pharmacy.
SUBSTANCE: invention represents new derivatives of 17,20-dihydrofusidic acid of the formula (Ia)
wherein Q1 and Q2 are similar or different and mean -CO-, -CHOH-, -CHRO- wherein R means (C1-C4)-alkyl; Q3 means -CH2-; Y means hydrogen atom (H); A means -O- or -S-; R1 means (C1-C4)-alkyl, (C2-C4)-olefin, (C1-C6)-acyl, (C3-C7)-cycloalkylcarbonyl, benzoyl. These derivatives are used in pharmaceutical compositions for treatment of infectious diseases, in particular, in composition for topical applying for treatment of infectious diseases of skin and eyes.
EFFECT: valuable medicinal properties of compounds.
22 cl, 7 tbl, 41 ex
FIELD: organic chemistry, chemistry of steroids.
SUBSTANCE: invention relates to a new method for synthesis of 6β-formyl-B-norcholestane-3β,5β-diol of the formula (I): by constricting six-membered B-ring of cholesterol. Method involves photooxidation of cholesterol with air oxygen at irradiation by visible light in the presence of porphyrine photosensibilizing agent immobilized on low-molecular fraction of copolymer of tetrafluoroethylene and perfluoro-3,6-dioxo-5-methyl-6-sulfonylfluoride octene-1 in the mass ratio porphyrine photosensibilizing agent : cholesterol = 1:(12-15). As porphyrine photosensibilizing agent 5,10,15,20-tetraphenylporphyrine can be used. Method shows technological simplicity, it doesn't require rigid conditions and provides the high yield of the end product.
EFFECT: improved preparing method.
2 cl, 3 ex
FIELD: medicinal industry, sterols.
SUBSTANCE: invention relates, in particular, to the improved method for producing sterols - lanosterol and cholesterol from wooly fat that can be used in preparing medicinal and cosmetic preparations. Method is carried out by alkaline hydrolysis of raw, extraction of unsaponifiable substances, removal of solvent and successive isolation of lanosterol and cholesterol. Alkaline hydrolysis of raw is carried out with a mixture of ethanol, sodium hydroxide, pyrogallol and water at temperature 70°C for 4 h at stirring in the following ratio of components: raw : ethanol : sodium hydroxide : pyrogallol : water = 100.0:(300.0-350.0):(30.0-35.0):(0.01-0.05):(7.5-12.0), respectively, with the indicated mixture with addition of toluene in the following ratio: raw : ethanol : sodium hydroxide : pyrogallol : toluene : water = 100.0:(220.0-255.0):(30.0-38.0):(0.05-0.12):(100.0-137.0):(2.5-7.0), respectively, and lanosterol is isolated by precipitation from mixture of methylene chloride and ethanol in the ratio = 1:1. Before removal of solvent unsaponifiable substances are extracted at temperature 50°C for 2-3 h at stirring. Invention provides increasing yield of the end product, enhancing qualitative indices and reducing cost of production.
EFFECT: improved producing method.
2 cl, 3 ex
SUBSTANCE: polyaminosteroid branched derivatives of general formula I are described, where R1 is saturated or unsaturated C2-C10alkyl (conjugated or branched) or methyl, R2 is COOH or branched polyamine fragments, R3 is H, OR19, where R19 is H or C1-6acyl, R4 is H, R5 is H, CH3, R6 is H, CH3, R7=R8=R9=H, R10 is H, CH3, R11 is OH,-OSO3, - O-acyl, -(Z)n-(NR-Z)p-N(R)2, Z is linear hydrocarbon diradical, n=0, 1, p=1, R-H, C1-6alkyl, C1-6aminoalkyl, possibly substituted by C1-6alkyl, R12=R13=R15=H, R16 is H, OH, R17 is H, R18 is H, CH3, possible double bond. Compounds possess bactericidal activity and can be used for prevention of bacterial infections.
EFFECT: production of polyaminosteroid derivatives, possessing bactericidal activity which can be used for prevention of bacterial infections.
27 cl, 31 ex, 1 tbl, 2 dwg
SUBSTANCE: claimed invention describes paroxetine cholate or salt of cholic acid derivative and composition, which contains paroxetine and cholic acid or its derivative. Also described is pharmaceutical composition for treatment of depressive states, containing paroxetine salt or composition. Pharmaceutical composition can be part of peroral medication, swallowed without water, on form of disintegrating in mouth paroxetine tablet.
EFFECT: obtaining paroxetine cholate or salt of cholic acid derivative, which can be used in pharmacology.
19 cl, 38 ex, 12 tbl
SUBSTANCE: invention refers to synthesis of biologically active substances, in particular specifically, to improved method of producing 2,3-monoacetonide 20-hydroxyecdysone of formula found in very small amounts in some plants, e.g. Rhaponticum carthamoides. Method is implemented by interaction of 20- hydroxyecdysone (1.0 g, 2.08 mmole) and acetone with phosphomolybdic acid (PMA) added. As suspension is effected by mother compound in PMA acetone (0.3 g, 0.16 mmole), after 5 min homogenisation of reaction mixture is observed to be steamed by neutralisation with 0.1% sodium hydrocarbonate solution with following ethyl acetate and chromatography extraction of the end product, thus resulting in isolation of the end 2,3-monoacetonide 20- hydroxyecdysone of 32% yield.
EFFECT: method is highly selective and single-stage.
2 cl, 1 ex
SUBSTANCE: claimed invention relates to novel fusidic acid derivatives of general formula [I], where X represents halogen, trifluoromethyl, C1-C7alkyl, substituted with phenyl, C2-C9alkenyl, optionally substituted with C1-C7alkyl, halogen or phenyl, phenyl, optionally substituted with one or two similar or different substituents, selected from group consisting of halogen, C1-C7alkyl, C2-C9alkenyl, phenyl, C1-C6alkoxy, nitro, C1-C6alkyltio, trifluoromethyl and cyano; or X represents naphtyl; Y and Z both represent hydrogen or together with bond C-17/C-20 form double bond between C-17 and C-20 or together represent methylene and form cyclopropane ring in combination with C-17 and C-20; A represents O, S or S(O); B represents C1-6alkyl, C2-6alkenyl, C1-6acyl, phenyl or benzoyl, where C1-6alkyl is optionally substituted with one or more halogens, hydroxy, C2-6alkenyl, phenyl, C1-4heteroaryl or C1-6alkoxy; Q1 represents -(CHOH)-, or -(CHW)-, where W represents halogen or azido; Q2 represents -(CHOH)-; to their pharmaceutically acceptable salts and easily hydrolysed esters and to pharmaceutical compositions, including said derivatives, as well as to their application in therapy.
EFFECT: application in therapy.
31 cl, 127 ex, 5 tbl
FIELD: production processes.
SUBSTANCE: invention refers to wood working and wood chemical industries. Birch bark is broken down, mixed with liquid, the mixture is held at temperature higher than mixture freezing temperature, then triterpene compounds are separated from lingo-adipic residue with the following filtration and drying. Birch bark is additionally broken down by method of impact-abrasing and/or abrasing effect till obtaining birch bark flour. Birch bark flour is mixed with liquid with density of 0.999-0.958 kg/m3. Mixture is held for 0.1-10 hours and then separated by flotation to hydrophobic and hydrophilous fraction. Solution remaining after separation is condensed and dried. Obtained hydrophobic fraction - mixture of triterpene compounds - is exposed to recrystallisation in ethanol with activated charcoal and then betuline, solution of triterpene compounds in ethanol and mixture of triterpene and polyphenol compounds at carbon matrix is obtained. Or triterpene compounds mixture is separated to fractions in carbon-dioxide extractor and betuline, dry mixture of triterpene and polyphenol compounds are obtained. Hydrophilous fraction - lingo-adipic flour - is separated from liquid and dried out.
EFFECT: increase of environmental safety and method effectiveness.
6 cl, 4 ex, 3 dwg
SUBSTANCE: present invention presents a preparation to reduce insulin resistance. The preparation contains 3-O-v-D-glucopyranosyl-4-methylergost-7-ene-3-ole, or an extract made with using an organic solvent, or an extract made with using hot water, or a drained liquid of a plant of Liliaceae family, or fraction thereof which contains this compound as an active component.
EFFECT: production of the preparation which is suitable for inhibition of adipocytokine production, particularly adipocytokine which cause insulin resistance, and for prevention of pathological conditions caused by insulin resistance, or simplification of clinical course of said pathological conditions.
9 cl, 3 ex

domain: chemistry


text:
Frameworks to support the application of behaviour change theory to the choice of behaviour change techniques (BCTs) in designing digital behaviour change interventions (DBCIs) are becoming well established, and have been employed by the authors in the development of StopApp. However, guidance on the next stage—effective operationalisation (translation) of these BCTs to a digital context, including the precise delivery and design of “behavioural intervention technology” (BIT) elements, is still in its infancy. This is despite growing recognition of the need to optimise engagement and usability, alongside a theoretical basis, for intervention effectiveness. The aim of this study was to explore methods to translate BCTs into digital content in an accurate and systematic manner. We describe the process of using co-creation (user-led) rather than expert-driven methods in the development of user-facing features and design in StopApp, including the iterative “bottom-up” and “top-down processes” necessary for accurate BCT translation. We found a small disparity between the intended and actual BCT content, reflecting the difficulties of translating BCTs into digital intervention content and the need for better guidance and methodical approaches to enhance this under-researched process. The involvement of our Patient and Public Involvement (PPI) group throughout these processes is described.
- Health behaviour change
- Behavior change techniques


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Jon Favreau got a jump on the rest of the movie Super Bowl competition by tweeting an action packed new spot for “Cowboys & Aliens” with Daniel Craig, Harrison Ford and Olivia Wilde a few hours before the game.
The new :30 spot gives moviegoers a much better look at the alien critters who’ve attacked the Old West and gives Olivia Wilde a couple of beauty shots that we’re certainly not complaining about. In fact, our only complaint is that the spot isn’t a :60 so we could see more.
“Cowboys & Aliens” opens nationwide on July 29, 2011. What do you think of Favreau and company’s Super Bowl spot? Share your thoughts below.


text:
REVIEW OF THE SENSITIVITY / SUSCEPTIBILITY OF PLASMODIUM FALCIPARUM IN AFRICA WITH SPECIAL REFERENCE TO ZIMBABWE
Plasmodium falciparum resistance to the available antimalarial drugs has been described in many parts of the world, especially in sub-Saharan Africa where malaria is endemic. P. falciparum resistance to the most widely used antimalarial drug, chloroquine, was first reported from Kenya in a tourist in 1979. Since then, many countries in Africa started to monitor the susceptibility of falciparum malaria infections to antimalarials using either the in vivo or in vitro tests. Results from these tests have shown that resistance to virtually all antimalarial drugs except for artemisinin and its derivatives exists in many parts of the continent. Chloroquine resistance of over 85% (of suitable cases tested in vivo) varying from RI to RIII levels have been reported. Sulfadoxine/pyrimethamine, amodiaquine and quinine resistance also exists in some parts of Africa. Resistance to mefloquine and halofantrine, though not widely used has been documented in a few countries including Zimbabwe.
Drug resistance continues to spread in Africa and it has become a major problem in the control of malaria in recent years necessitating the use of drugs which are more expensive. This review looks at the susceptibility of P. falciparum (the cause of more than 90% of all malaria infections) to antimalarial drugs in Africa with special reference to Zimbabwe. Research efforts and control measures that are being undertaken to map out, rapidly diagnose and control drug resistance in an effort to reduce morbidity and mortality due to malaria are also discussed.
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If you’ve ever had a favorite shirt or dress that’s started to fade, you know how disappointing it can be. Not only does the faded fabric look bad, but it can also start to feel rough and thin. Let’s discuss how to brighten faded clothes and how to keep colors bright in the future. By following these simple steps, you can keep your clothes looking new for years to come!
How to Brighten Faded Clothes
Faded clothes can be a huge bummer, especially if it’s one of your favorite items. Let’s talk about how this happens first, and then we’ll talk about how to make clothes look new again.
Why Do Clothes Get Faded Over Time?
The sun is the number one cause of fading, but washing and drying your clothes can also contribute. Every time you wash your clothes, the fabric fibers loosen, and the color fades a little bit. This is why it’s important to follow care instructions when laundering your garments. Hot water and bleach are two of the biggest culprits when it comes to fading clothes. Does the dryer fade clothes? Yes, it can be a big culprit. If you must put your clothes in the dryer, make sure to use the lowest heat setting possible.
How to Make Clothes Bright Again
Now that you know how and why clothes fade, let’s talk about how to brighten faded clothes again. If your clothes are already faded, there are a few things you can do to brighten them up.
Sunlight: For white clothing, sunlight is the best way to naturally brighten clothes. Hang your faded garments in direct sunlight for a few hours, and you’ll notice a big difference. If you don’t have access to sunlight, you can also use a bleach solution to brighten up your clothes.
Dye, natural or store-bought: For colored clothes, dyeing is a great way to bring new life to old clothes. You can buy dye at your local craft store, or you can use natural dyes like turmeric, coffee, or tea.
Vinegar: How to brighten colored clothes? Try soaking them in vinegar for 30 minutes before washing them. You can also add a cup of vinegar to your regular laundry detergent to help prevent fading.
Salt: Salt is another great way to brighten up faded clothes. Add a half cup of salt to brighten clothing along with your laundry detergent and wash your clothes as usual. The salt will help lock in the color and prevent further fading.
Wash with same color new clothes: Washing your clothes with brand new clothes of the same color can result in the color of the new clothes bleeding into your old faded clothes.
Laundry Tips to Avoid Fading
Now that you know how to brighten up faded clothes let’s talk about how to keep laundry from fading in the first place. By following these simple tips, you can keep your clothes looking new for years to come!
Wash with cold water: Washing your clothes in cold water is one of the best ways to prevent fading. Hot water is a major culprit when it comes to fading clothes.
Hang dry garments: The sun and the heat from the dryer can both contribute to fading, so try to hang dry your clothes whenever possible.
Wash inside out: Washing your clothes inside out helps to protect the color from fading.
Use a color catcher sheet: A color catcher sheet is a product that you add to your laundry detergent that helps to protect clothes from fading.
Choose detergent wisely: The best laundry detergent to keep colors from fading is one that’s made for the type of clothes you’re washing. Options like Dark Protect from Oxiclean are specially made for dark clothes.
Avoid bleaching: As we mentioned before, bleach is one of the biggest causes of fading. If you must use bleach, make sure to dilute it with water and only use it on white clothing.
Wash with salt on the first wash: Adding salt to your first wash helps to set the color and prevent fading.
By following these simple tips, you should know how to brighten faded clothes and how to extend the life of your clothes as well. For more helpful laundry tips, check out our towel washing tips blog as well as our wrinkle removal hacks! And for any issues with your appliances, call the top-rated washer and dryer repair team at BSC!