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June 2021 American Perspectives Survey
Interview Dates: June 11–June 27, 2021
The June 2021 American Perspectives Survey (APS) investigates American’s work preferences, unemployment experiences, and career aspirations as they navigate the new post-pandemic labor market. The national survey of 2,422 adults, which included an oversample of 406 unemployed respondents, was conducted using Ipsos’ probability-based online KnowledgePanel. The survey also includes questions to better understand the experiences of unemployed Americans, their career aspirations, personal values, and views about what it means to live a fulfilling life.
Survey Report: The great American jobs reshuffle
|APS June 2021 Topline Questionnaire.pdf

domain: sociology


text:
The Fed and How It Got That Way
Here is a quick history of the Federal Reserve and an overview of what it does.
Have A Question About This Topic?
Learn about the importance of having an estate strategy in this helpful and informative video.
There are benefits and limitations when you decide to donate stock.
The market is as unpredictable as the weather. We'd love to help you prepare.

domain: finance


On Jan. 9, 1984, Van Halen released their seminal album “1984,” an album that would go on to define the sound of the eighties. By the mid-80s, Van Halen was arguably the biggest rock band in the world. They had managed to combine the grimy club sounds of the Los Angeles metal scene with the commercial pop music that dominated the airwaves. Spearheaded by the banshee wailing of David Lee Roth and the innovative guitarwork of Eddie Van Halen, they crashed into 1984 with one of the greatest rock records to date, appropriately titled “1984.”
The album opens with the eponymous song “1984.” This instrumental track contains warbling synths that lend the impression of an alien arriving, perhaps trying to tell the audience that this album was something they had never heard before. Fittingly, the album immediately jumps into its biggest hit, the synth-driven “Jump” (pun intended). This stadium pop anthem seems out of place in the course of the album but contains all the hallmarks of a classic Van Halen song: David Lee Roth’s unique vocal stylings, Eddie Van Halen’s musical genius on both the keyboard and guitar, Michael Anthony’s backup vocals and Alex Van Halen’s solid drumming.
Any song following this massive hit may seem to pale in comparison, but “Panama” may surpass “Jump” as the most anthemic and traditional Van Halen song on the album. A hard rocker with lyrics that seem to refer to both a woman and a car, a common trope in 1980s rock music, “Panama” is certainly one of the standout moments from the album.
The next two songs, “Top Jimmy” and “Drop Dead Legs,” have the unfortunate place of standing between the powerhouses of “Panama” and “Hot For Teacher.” “Top Jimmy” is a fast-paced rocker that picks up the tempo of an otherwise slower-tempoed album. “Drop Dead Legs” is a slower-groove-paced song that contains some of Eddie Van Halen’s most underrated guitar work. Of the two, “Drop Dead Legs” is generally regarded as an overlooked Van Halen song that holds its own on an album full of chart-topping hits.
On the other hand, “Hot For Teacher” starts with one of the most iconic drum intros in rock music, with Alex Van Halen’s bass drums imitating the sound of a motorcycle. This track also features David Lee Roth doing his usual blend of singing and talking as he spends most of the track living out his grimy schoolboy fantasy, fawning over a new teacher. The solo reaches its peak with a crescendoing Eddie Van Halen solo with some of his most bluesy playing, emulating his hero, English guitarist Eric Clapton.
“I’ll Wait,” perhaps the most 80s of all the songs, follows up “Hot For Teacher.” With a power ballad with the accompanying garnishings of that type of song, including loud synths and a powerful guitar solo at the climax of the song, David Lee Roth’s vocals seem to be actively channeling Sting of The Police in a sort of lazy tropical flow.
The album concludes with two of the oddest Van Halen songs. “Girl Gone Bad” opens with an intro that would not be out of place on a progressive rock record — before David Lee Roth enters the song, the instrumental almost sounds like a song from the progressive Canadian powerhouse trio Rush. This intro displays the synergy between the two Van Halen brothers as well as the diverse musical environments in which they could thrive in. Roth brings his sleazy LA vocals to create something that would become the blueprint sound for the Hair Metal bands that would arise in the wake of the implosion of Van Halen. The concluding track, “House of Pain,” is one of the most explicit songs in Van Halen’s back catalogue — David Lee Roth sends off the album while singing about a breakup, packed with suggestive double entendres about his partner’s preference for pain.
It is fair to say that Van Halen opened the floodgates for rock bands to mesh heavy metal instrumentals with pop vocals. Some of the greatest arena rockers of all time capitalized on this trend, including Mötley Crüe, Bon Jovi and Guns N’ Rose. Though each group had their unique stylistic differences, all followed the Van Halen blueprint of an eccentric lead singer with the vocal ability to shatter glass at a moment’s notice paired with a gunslinging guitar player who could play at a dizzying rate that would leave listeners dazed and confused as to what they just had heard.
With the album cover iconically depicting an angel’s baby smoking a cigarette, “1984” is an important body of work for modern listeners as a timestamp in the evolution of rock music — the birth of hedonistic rock with pop appeal. This record shaped the rock music of the 80s and should be viewed as the progenitor of Glam Metal. Eddie Van Halen’s playing so radically changed the way that the guitar was played that it is almost impossible to be a modern guitar player and not be influenced by his work in some way. In the same way that Led Zeppelin’s fourth self-titled album is often hailed as definitive for an entire generation of rock fans, “1984” became the soundtrack for the generation of hard rock still glorified by rock dads and Urban Outfitters alike.


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Eye Associates of Monmouth
John Ghobrial, MD
Access Telehealth Services with Ease
When you don’t have the time or the ability to visit your doctor’s office for medical care, you can turn to telehealth. The exceptional team at Eye Associates of Monmouth, in Colts Neck, New Jersey offers telehealth to new and existing patients, giving you the ability to videoconference with your doctor, receive medical care, and be prescribed medication while staying in the comfort of your own home. Request a virtual appointment online, or if you’d like to learn more about how to register for telehealth, call the office. The friendly staff can provide the information you need to access virtual medical services.

domain: medical


text:
This week I made a video on Instagram on how I tie my turban. I was a bit surprised at how many likes and comments it got. The video on Instagram was a short one. I have made a much better vide on how to tie two different turbans. You can see the video right here.
Have a lovely day

domain: hobby


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SCR Men’s Nike Legend Long Sleeve
The SCR Nike® Men’s Long Sleeve Legend T-Shirt is an essential for every man. No matter what your style, this fabrication is designed to keep you focused and prepared the whole day through. Moisture-wicking properties are designed to keep this garment dry as you perspire, while the rib crewneck gives you comfortable mobility. The Legend Tees are best sellers for a reason!

domain: design


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A Clifford Chance team including lawyers from the firm’s Madrid office advised investment bank Natixis and the life insurance companies AIG, Pacific Life and Metropolitan Life on a refinancing for a transmission line project in Peru.
The Carhuaquero – Cajamarca Norte – Cáclic – Moyobamba Nueva transmission line project in northern Peru consists of four transmission lines and four substations spanning the Peruvian departments of Cajamarca, Amazonas and San Martín, and covering 371 kilometres.
The sponsor of the project, Madrid-based Bow Power, is a joint venture owned by the ACS Group and Global Infrastructure Partners.
The refinancing structure consisted of a $75.3 million fixed/floating-rate senior secured term loan facility and a $99.5 million aggregate principal amount of senior secured notes.
Both the notes and the loan facility have a 29-year maturity and are secured by a pledge or assignment of all of the concessionaire’s assets and rights to a collateral agent located in Peru.
It was the first private placement in Latin American for Natixis, which acted as sole bookrunner and placement agent.
The multijurisdictional Clifford Chance team included Madrid-based partner José Guardo (pictured), as well as associates Marta Ruiz Manrique de Lara and Eugenio Fernández-Rico Núñez.


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The issue of same-sex marriage frequently sparked emotional and political clashes between supporters and opponents for tables on same-sex marriage around the world, in the united states, and in australia, see below. Same-sex marriage, also referred to as gay marriage, is marriage between two persons of the same sex the federal government of the united states does not recognize the marriages of same-sex couples and is prohibited from doing so by the defense of marriage act. Growing society, current social issues and family morals are constantly changing the dynamics and aspects of - recently, same sex marriage has become a major issue in the united states allow same-sex couples the right to domestic partnerships, civil unions, and marriages [tags legalizing same-sex marriage can bring economic benefits to the states and lastly legalizing gay marriage.
States that many same-sex couples want the right to legally marry [and] honor that arises and issue with me because although i don't judge them i definitely won't be apart of opinions and views same-sex marriage in today's society same-sex marriage, the marriage or union between two. Same-sex marriage advice: same-sex marriage boosts the economy this reason speaks that same-sex marriage should be legal there are numerous same sex couples raising children in loving homes the history of same-sex marriages laws in the us. To same-sex marriage would be linked to a politically conservative tendency to justify the societal to same-sex marriage would be serially mediated by the endorsement of conservative ideology and derisively on same-sex couples parenting abilities, no matter if the couple is two men or two women.
Same-sex couples have to be more proactive when it comes to financial and estate planning, especially if they plan to get married and live in a looks to state laws, so if a couple is legally married and lives in a state that recognizes the marriage, social security benefits (including survivor benefits. Same-sex marriage in the united states expanded from one state in 2004 to all fifty states in 2015 through various state court rulings, state legislation, direct popular votes, and federal court rulings.
Public opinion should society accept homosexuality united states ranks #13 out of 39 same-sex marriage in united states current status (since jun 26, 2015) states must now issue marriage licenses for same sex couples and recognize same-sex marriages performed in any state. Social security & retirement in united states v windsor, the supreme court struck down certain provisions of the federal defense of marriage act (doma) and ruled that the federal government must recognize same-sex couples who are legally married under state laws. Same sex couples to take place and recognize same sex marriages carried out in other states in 14th april 2010, an executive order issued by president barack obama was relayed to the us department of same sex couples in the adoption of children is illegal across the united states same sex married couples and lgbt individuals as a whole have faced serious hate crimes in the.
That prohibiting same-sex couples from marrying might violate the state's constitution rights to same-sex couples provides equal treatment under the law and unlocks a host of government getting same-sex couples to simply come out of the closet to friends and family to show the world that their. I want to begin by saying how delighted i am to be debating contradiction on this very important social issue of the united sates, has pointed out that since 1888 the united states supreme court has ruled that same-sex couples are similar to heterosexual couples in essential ways and that they are as to exist -- it is a pre-political concept, a fundamental cornerstone to the very existence of society. Married same-sex couple awaits ruling on federal benefits one side of issue has some momentum two separate appeals -- challenges to a state -- state referendums the california high court had earlier concluded same-sex marriage was legal, but the 2008 voter-approved proposition 8 abolished it.
In 1996, the us congress passed and president bill clinton signed the defense of marriage act, a law that prohibited federal recognition of same-sex marriages the gay airman who took on the us military 25 march 2013 us republican senator rob portman favours gay unions. Refusing to issue marriage licenses to same-sex couples professor jean twenge, a psychologist at san diego state university who worked on the study, said this has asked americans about their attitudes toward same-sex sexual behaviour since 1973 and about sexual partners since 1989. The legal system in the united states evolved out of the laws contained in the bible free balanced, non-partisan discussion of political & social issues for debate (pros and cons - decision making politics.
Same-sex couples in the united states in 2013 may have been much lower than the census growth in the number of same-sex married couples is fueling demand from government officials than sex - that is, opposite-sex couples were identifying themselves as same-sex couples on the. Support for same-sex marriage by the national association of the deaf (nad) until same-sex marriage became available everywhere in the us, married same-sex couples had to be very careful where they lived and to where they traveled.
Same sex marriage recently the discussion of same sex marriage has been a hot topic in both the political and religious arenas by 11 countries in the world, and there are also several countries that proposed legal recognition of same sex marriage and it was pending in the legislative house. Same-sex couples may wonder if an annuity with a guaranteed lifetime income will become void when a spouse dies in a state that doesn't recognize their marriage however, the retirement of widows and widowers will be much more financially stable than in the past. The issue with same-sex marriages same sex marriage in the philippines 2330 words | 10 pages.

domain: news


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From Murcia Airport we offer you your own tailor made private airport transfer to the
beautiful costal resort of La Zenia
La Zenia is a famous resort situated on the Costa Blanca, forming part of the coast of Orihuela.
It’s a well-situated resort, allowing you to fly into both Alicante or Murcia airports, which are both respectively 30 and 20 minutes drive from La Zenia.
La Zenia boasts a fine blue flag beach with great facilities for both families with children, and those looking for water sports. Within easy reach is the Orihuela Costa Resort Complex with its outstanding leisure facilities including an Olympic sized swimming pool, tennis, squash, a well equipped gym, bowling and a bar and restaurant.
Once you arrive in La Zenia by private airport transfer you will find that the surrounding countryside is abundant with beautiful orange and lemon groves and close by you will find two lakes where flamingos and other birds nest.
The local cuisine is typically that of the Costa Blanca, which combines delicacies from both land and the Mediterranean Sea. Many civilizations have lived in this area (Celts, Iberians, Greeks, Romans, Muslims), all of which have all left their mark on the gastronomy.
The diet is a healthy Mediterranean one; the Costa Blanca is rich in fish, vegetables, olive-oil, rice and fruit and the ingredients which are all used to prepare delicious, healthy dishes, such as Paella Valenciana, Arroz Negro (black rice), Arroz al horno (Oven baked rice), Arroz a banda (fish and rice stew), Arroz del Señoret (Princes rice).
At Murcia Airport for your private airport transfer you will be met in the arrivals hall , where your uniformed driver will take you to your chosen destination in La Zenia.
I have now used this Company on two separate occasions for journeys between Alicante Airport and Javea. On each occasion the service and in particular communications were excellent. Maybe I was lucky but I would certainly not hesitate to use them again.
With two teenage children, a silly o’clock in the morning flight and a bundle of luggage, we didn’t fancy buses, trains and more buses to get to our holiday flat in Denia from Alicante airport so I prebooked a taxi from Beniconnect. It wasn’t cheap, 125€, but we got a spacious air conditioned vehicle with a very courteous and friendly driver Enrique who took us quickly and safely to our destination.
Pickup is always on time and buses are always clean and comfortable. Drivers are always very patient and courteous. Would highly recommend Benniconnect for transfers to and from Alicante Airport.
Booked return private coach transfer from airport to Villa. New modern coach with AC, free WiFi and USB charging ports. Coach ready at airport, no waiting around and on return collected on time. Both drivers were very courteous and helpful. Took the stress out of the transfer. We use again, highly recommend.
We found the Beniconnect ideal way to be taken to your hotel without having to drive. The bus was there waiting for us at the airport and was early for the return journey. Would definitely use again.
All bookings that are made today will automatically have this discount applied!

domain: geography


- REFRIGERATION AMMONIA COMPRESSORS
- ICE MACHINE
- REFRIGERATION VESSELS
- REFRIGERATION SYSTEM ACCESSORIES
- REFRIGERATION PURGERS
- EVAPORATIVE CONDENSERS
- HB PRODUCTS
- WITT PRODUCTS
The high side control offers a simple mechanical maintenancefree solution to expanding liquid refrigerant from the high to the low pressure side of a refrigeration system, without gas passing. From technical and economical point of view this is the optimum and safest way of expanding refrigerant and handling condensate return.
HR1- HR4, HS50 and HR1BW:
Max. allowable pressure PS: 25 bar between +75/-10°C 18,75 bar between -10/-60 °C Test pressure PT: 37 bar oil pressure
Max. allowable pressure PS: 40 bar between +90/-10 °C 30 bar between -10/-60 °C Test pressure PT: 59 bar oil pressure
Max. allowable pressure PS: 65 bar between +100/-10 °C 48,75 bar between -10/-60 °C Test pressure PT: 100 bar oil pressure
HS30 - HS40
Max. allowable pressure PS: 40 bar between +75/-10 °C 30 bar between -10/-60 °C Test pressure PT: 59 bar oil pressure
Reduction of filling capacity:
With the WITT HR & HS condensate is continuously expanded to the low pressure side. That means during normal operation nearly the entire refrigerant charge is stored on the low pressure side, whereby a high pressure receiver is unnecessary.
Due to the mechanical design no wiring or additional controls are required. In the event of a power failure condensate is drained safely to the low pressure side, ensuring highest operational safety.
Since refrigerant is always drained by the float whenever condensate accumulates, lower condensing temperatures can be utilized without a need to consider other control criteria. Compared to a system operating with traditional expansion valves there is neither a need for sub-cooling liquid nor superheating the suction gas. (Remark: energy savings of up to 13% are quite possible, i.e. with 5 K lower condensation temperature).
Stable plant operation:
Pressure fluctuations are avoided by continuous condensate drainage, guaranteeing stable operation of the whole system.
Reduction in maintenance cost:
During downtimes of the refrigeration system there will be slow pressure equalization when using float regulators with low pressure nozzles. Systems with only one compressor can be started from an unloaded condition without need for additional controls
|Total height including valves [mm]||Diameter [mm]||Depth [mm]||Connections [DN]||Weight [kg]|
|HR 1 BW||40 *||310||200||365||25||10|
|HR 1||95 *||440||200||425||25||13|
|HR 2||390 *||480||250||445||32||23|
|HR 3||1,160 *||640||345||555||50||54|
|HR 4||3,345 *||910||406||765||80||135|
|HS 30||1,045 *||510||290||655||100/50||49|
|HS 40||2.815 *||685||400||775||150/80||107|
|HS 50||4.745 *||855||406||765||200/80||135|
|WP 2 HR||260 **||460||250||475||32||26|
|WP 3 HR-65||860 **||545||355||650||50||68|
* Refrigerant: NH3, T0 = -10 ° C, TC = + 35 ° C | ** Refrigerant: NH3, T0 = + 35 ° C, TC = + 75 °
Visitors Counter : 105665


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Zum Seitenende Übersicht Artikel Home & Impressum
First the link to this week’s complete list as HTML and as PDF.
To my knowledge Croft et al. is the first report about a female menopause and grandmothering in a non-hominid species and should provide a good test for its differing explanatory hypotheses.
Zum Anfang Übersicht Artikel Home & Impressum

domain: literature


text:
I am graphic designer, specialising in the fields of corporate identity design and designing promotional material such as brochures, leaflets, websites, letterheads, business cards, packaging, exhibition displays and more.
Member since: January 09, 2009
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"great in ideas and communication and understand what is the best for the business"
"Fantastic working with Petro - very responsive to requests and talented designer. "
"GraphicSupply delivered exactly what we were looking for in a logo design. Designer was very responsive to all the changes we requested and submitted the changes promptly. Would definitely work with designer again!"
"Took our brief and created a perfect logo for our technology company. Great job!"
"An amazing design and a great design experience! I could not be happier. Thank you!!"
"Update of business card was very simple. Contact information was changed, and a vector image was added. The job was done quickly and done well. "
"I can only say good things about GraphicSupply. He addressed all my requirements in a timely fashion and produced excellent designs, time after time. I'm looking forward to working with GraphicSupply on a 1:1 basis in the near future. Also, kudos t..."
"The job was simple but challenging...to create a logo to headline a professional website where hip, cool millennials could come for pre-med advice, resources, answers and purchases. GraphicSupply was the only designer who came in with one solid design, ..."
"Awesome. Very creative and professional. We love the simplicity and style of design.... a perfect representation of our company."
"Caosao had submitted a very simple, clear and timeless logo, exactly as I had requested. He was also very accomodating in making any changes I had asked for in a quick and precise manner. It was a pleasure to work with such a talented designer. Thank..."
"Very gifted designer. Responsive with rapid response time. Highly recommended."
"Excelente propuesta tanto en diseño como en colores. Quedé realmente satisfecha! Gracias!"
"Caosao delivered a simple, impactful and compelling design. Moreover, he was extremely quick in responding to requests and suggestions, yet never afraid to offer his own counsel and point of view. Very helpful, very imaginative, very quick. I would not ..."

domain: artistic


text:
Holy Week and Easter offerings in the city
Holy Week and Easter is upon us again, and for those who haven’t made out of town trips or holidays abroad, there is much to be done in the metro for quiet time, reflection and family bonding.
Easter bunny has been hopping around Marriott Café Bakery since March 15 with delightful goodies perfect to give away. Even from afar, the quirky animal chocolate sculptures—200 grams of Belgian chocolate shaped in Porky Pig, Marriott Bunny, Honey Bee and Bunny Racer—catch one’s attention instantly.
Taking into consideration that Holy Week is a period where families and friends get together, Marriott’s Easter room package is inclusive of overnight stay in a deluxe Room, buffet breakfast for two adults and two kids, and P500 worth of dining credits in the Marriott Café Bakery. This staycation is available from March 28 to April 2.
For Easter, the Sunday Brunch Buffet is made extra special for guests.
Kids get to play around at Marriott’s Candyland with huge installations of their favorite sweets. They also get to join the hunt for the “Golden Egg” that comes with awesome prizes of dining vouchers. More kiddie activities include magic show, balloon twister, face painting and mascot visits.
Kids get to explore the playful Mattel Easter Playground in the nine Easter Worlds. There are also kiddie games and activities for everyone’s enjoyment in each Easter world. Moreover, on-stage games, magic show, and a grand raffle will keep families and participants entertained throughout the program. Registration starts 10 a.m. at Eastwood Mall Open Park while Easter Worlds open at 11 a.m. Easter activities commence at 1 p.m.
Find your happy place at Diamond Hotel Philippines and join a colorful Easter celebration on April 1from 10 a.m. to 2 p.m. Head on to the Diamond Ballroom where there will be lots of dancing, singing and playing. Tickets are inclusive of a snack box filled with delicious goodies and a tons of fun activities! And just like your favorite, happiest creatures, keep that positive spirit because kids will get a chance to win an XK X252 Shuttle Quadcopter Drone in the Grand Raffle Draw. The Easter event includes face painting, glitter tattoo, fun games, a kid’s salon, and live musical entertainment. Plus, get ready to be amazed by the incredible tricks of Little Miss Magician Kyla Javier who was featured in the show “Little Big Shots.” More surprises await all guests and are sure to make your day brighter.
@Marco Polo Ortigas
Experience a staycation like no other at the Forbes Travel Guide twice-in-a-row Five-Star Award winner, Marco Polo Ortigas Manila this Easter. Enjoy a breakfast buffet for two adults and two kids under six years old, and complimentary wireless internet access. Have a splash through the hotel’s indoor infinity pool, or hit the gym for that scheduled work out. Finally, indulge in a culinary journey with five signature outlets and their specialties—freshly-baked pastries and wide variety of coffee and tea at Café Pronto; stylish delights for an afternoon tea at Connect Lounge; live action stations showcasing the world’s famous dishes at Cucina; authentic Cantonese dining at Lung Hin; and cocktails over the stunning views of the Metro at Vu’s Sky Bar and Lounge.
The Smurfs like Smurfette and her friends Brainy, Clumsy, and Hefty, guests are invited to join the exciting Easter eggs-pedition through the Smurfs Easter Village on April 1 from 2 p.m. to 5 p.m. Kids will surely fun-filled activities such as Smurfs meet and greet, Smurfs movie screening, egg hunt at the Smurfs Village, fun games and activities, photo booth, interactive show at the Crimson Grand Ballroom, costume contest, egg-decorating contest, special giveaways, free loot bags, and a meal box.
Also offered is Easter weekend room packages that will get the kids and young-at-hearts hopping for fun. The overnight stay in a deluxe room includes a choice between two tickets to the Smurfs Easter Village or Sunday Brunch Buffet at Café Eight for two persons. The package also includes a buffet breakfast for two persons at Cafe Eight and an Easter amenity and a complimentary late check-out at 5 p.m. valid on March 31 to April 1, 2018.
@Novotel Manila Araneta Center
Pororo and his adorable animal friends invade Novotel Manila Araneta Center and kids are enjoined to have their baskets ready to hunt sweet Easter surprises with the cutest penguin character. Head to the Monet Ballroom from Porong Porong Forest on April 1 for fun games, bubble show, surprises and delights followed by an Easter Egg Hunt at the Versailles Garden. Moreover, enjoy an overnight stay in a superior room with buffet breakfast at Food Exchange Manila
for two adults and two kids ages 15 and below and wake up to an exciting Easter getaway in the city with an egg-citing room offer from March 29 to April 2.
Package includes two tickets to the Easter Party with Pororo and Friends at the Monet Ballroom, plus two hours use of Kids Club for the two little ones.
@Makati Diamond Residences
Feel at home in the well-appointed rooms with special features that include a fully- equipped kitchenette, a complimentary mini bar, and complimentary Wi-Fi and local city calls. Access the health club amenities including our 24-hour gym, daily TRX classes at the TRX studio, and an indoor lap pool. Participate in a cooking demonstration, or visit the inflatable play area, arts and crafts station, and more. Enjoy the privilege of a 20 percent discount on the Easter Brunch Buffet. Book a room with breakfast for two at the 41-sqm Studio or the larger 64-sqm One Bedroom Suite. The Holy Week room package is available until April 1, exclusive to local residents and foreigners with ACR I-Card certification.
@New World Makati Hotel
Ready the capes and super suits for an exciting Easter adventure at New World Makati Hotel. The adventure begins by booking a Super Easter staycation package for stays on until April 1. Enjoy a stylish room, Easter treats, complimentary WiFi, and two tickets to Easter Heroes vs. Villains party. Meanwhile, an afternoon of egg hunts, games, bubble show, bouncy castle, game booths, and more await participants. Ticket holders get access to the kiddie buffet, mocktail, and an Easter lootbag too. Finally, put on your best costume to take home the top prize.
@City of Dreams Manila
Families and friends looking for a Holy Week getaway can choose to visit City of Dreams Manila and avail of the Nobu family staycation package with complimentary DreamPlay access and more, or the Easter “Eggs-perience” at DreamPlay packed with thrilling activities and goodies for the season.
The Easter Sunday egg hunt, inspired by DreamWorks Animation’s “How to Train Your Dragon,” is one of the highlights of DreamPlay’s “Dragon’s Ultimate Easter Eggs-perience” on April 1. Guests who avail of the DreamPlay Easter package get to also decorate their own plaster dragon egg, bake and design egg-shaped cookies, watch the limited-time run of the “Book of Dragons“ movie in 4D, enjoy 10 percent discount on all How To Train Your Dragon merchandise and enjoy an all-day pass at the DreamWorks-inspired play space for the rest of the day.
@Seda Vertis North
In Quezon City, Seda Vertis North offers room packages and activities for the family. Choose from Holy Week staycation packages made more enjoyable by Movie Time and Arts and Crafts; or Easter Sunday activities, including egg hunts for kids and an amazing race for teens. Barbecue Night at the poolside is a special dining treat on March 30 and 31. If one prefers to drive to the South, head to Seda Nuvali in Sta. Rosa, Laguna and bask in its green and serene environment. Simpler still, stay in Seda BGC in Bonifacio Global City where the nearby “Reflections on the Stations of the Cross” at Bonifacio High Street enables guests to observe Lenten traditions, as do seafood, soups, salads and other non-meat dishes in Misto restaurant.
@Shangri-La at the Fort
This Easter, dine and choose from the egg-citing seasonal menus specially prepared by the Shangri-La at the Fort, Manila hotel chefs. At High Street Cafe, guests may enjoy a seafood dinner buffet on March 30 and April 1 and an Easter Sunday brunch on April 1. Meanwhile, High Street Lounge offers two special menus for the season: Chef Anthony’s Easter Egg-stra Special Afternoon tea set for two—which includes seafood favorites and the Easter Red Velvet cake, from until March 29—and The Easterrific Afternoon Tea buffet, available son March 30 and April 1. Finally, Canton Road offers a limited edition dim sum set menu for three on March 30 and April 1. For bigger groups, set menus are available per table of 10 persons.
On Easter Sunday, cute baby dinos will take over the BHS Activity Center for ‘Easter Dinoland.’ Dress up your kids in their most adorable dino costume and let them go on an adventure by joining in an egg hunt to earn special treats.
Capping off the Easter celebration is a special concert of multi-awarded singer/songwriter Gary Valenciano who will bring a soulful rendition of inspirational Christian music. Hip-hop/R&B singer, Quest and young indie artist, Clara Benin are also set to join the show. Listen and be moved by these powerful performances at the Globe Iconic BHS Amphitheatre starting 6 p.m.

domain: entertainment


text:
1/2 Photos of Biscuit Popper-Roll Bake
This is a great recipe I came across via my friend Sandy who's a fabulous cook. It's quick & simple and adds a little variety to the table. Kind of reminds me of monkey bread in how it's made. ** I used Pillsbury Homestyle or Big Grands **
My Private Note
Units: US | Metric
- 1Preheat oven to 350 degrees & spray 9x11 glass baking dish or pie dish with Pam.
- 2Open biscuit can & separate into 6 pieces. Cut pieces into halves or quarters for fuller effect. Roll biscuit pieces into ball shapes.
- 3Melt butter & roll biscuit balls in melted butter & place in baking dish. Sprinkle with spices.
- 4Bake at 350 degrees for 15-20 minutes until golden brown (if top browns too quickly before completely baked, you can use foil to cover top of dish for remainder of cooking time).
Browse Our Top Rolls/Biscuits Recipes
You Might Also Like...View All Rolls/Biscuits Recipes
Nutritional Facts for Biscuit Popper-Roll Bake
Serving Size: 1 (51 g)
Servings Per Recipe: 6
- Amount Per Serving
- % Daily Value
- Calories 244.7
- Calories from Fat 90
- Total Fat 10.0 g
- Saturated Fat 5.2 g
- Cholesterol 20.3 mg
- Sodium 741.2 mg
- Total Carbohydrate 34.2 g
- Dietary Fiber 1.2 g
- Sugars 4.7 g
- Protein 4.8 g

domain: food


text:
Plant Physiological Responses to Rising CO
Modify Simulated Daily Runoff Intensity With Implications for Global‐Scale Flood Risk Assessment
- Author(s): Kooperman, Gabriel J
- Fowler, Megan D
- Hoffman, Forrest M
- Koven, Charles D
- Lindsay, Keith
- Pritchard, Michael S
- Swann, Abigail LS
- Randerson, James T
- et al.
Published Web Locationhttps://doi.org/10.1029/2018gl079901
©2018. American Geophysical Union. All Rights Reserved. Climate change is expected to increase the frequency of flooding events and, thus, the risks of flood-related mortality and infrastructure damage. Global-scale assessments of future flooding from Earth system models based only on precipitation changes neglect important processes that occur within the land surface, particularly plant physiological responses to rising CO2. Higher CO2 can reduce stomatal conductance and transpiration, which may lead to increased soil moisture and runoff in some regions, promoting flooding even without changes in precipitation. Here we assess the relative impacts of plant physiological and radiative greenhouse effects on changes in daily runoff intensity over tropical continents using the Community Earth System Model. We find that extreme percentile rates increase significantly more than mean runoff in response to higher CO2. Plant physiological effects have a small impact on precipitation intensity but are a dominant driver of runoff intensification, contributing to one half of the 99th and one third of the 99.9th percentile runoff intensity changes.
Many UC-authored scholarly publications are freely available on this site because of the UC Academic Senate's Open Access Policy. Let us know how this access is important for you.


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The Boundless Land - Tom Gerou
Piano Solo, A set of original and fresh-sounding compositions for late intermediate level pianists. These descriptive pieces are musically satisfying and will appeal to teenage and adult pianists. While designed to be performed as a set, they can also be played individually. The compositions include "Northern Lights," "Prairie Winds" and "After the Harvest."
|Bow Brand Harp Snaren - speciale bestelbon||Noligraph Staff Writer||Pure Tone: Choir Folder / Choral Folder - Small||K3 Hits|


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These fab yarn dyed striped shorts made from our peached heavy jersey are super soft and comfy. With navy and cream yarn dyed stripe on one leg and red and cream yarn dyed stripe on the other, these stylish shorts are sure to be loved by your little one.
• Navy blue and cream yarn dyed stripe on one leg
• Red and cream yarn dyed stripe on the other
• Elasticated waistband
• Adjustable ties in navy
• Heavy peached jersey
• Navy blue and cream back pocket on red stripe side
• Coordinating items available
• 100% organic cotton
• Certified by Control Union to the Global Organic Textile Standard (GOTS)
• Made in India
• Machine washable at 40 degrees, or at 30 degrees to be kinder to the planet.
• Style number TB0520
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2017 Easton Hyperlite Fastpitch Softball Bat: FP17HL12
New from Easton for 2017! The Easton Hyperlite, similar to that of the newest Stealth, is a two-piece composite design that has a variety of different features. Made up of the HYPERLITE composite material, the barrel revamps the sweet spot for ultimate performance. The barrel connects to the ultra-thin 29/32 inch handle with the dependable CXN ZERO ConneXion technology that is engineered for absolutely no vibration and additional flex for more power. With an evenly balanced swing weight and Easton's HYPERSKIN grip, the Hyperlite fastpitch softball bat is ideal and recommended for younger players looking to take their game to the next level. Easton: Engineered for Glory!
This 2017 Easton Hyperlite Fastpitch Softball Bat: FP17HL12 features a -12 length to weight ratio, a 2 1/4 inch barrel diameter, and a number of different certifications. The Hyperlite is approved for play in ASA, USSSA, NSA, ISA, SSUSA, and ISF. Strengthen your game and order the Easton Hyperlite today with free shipping right here at JustBats.com. We're here for you from Click to Hit!
Easton FS400 -12 Fastpitch Softball Bat: FP16S400
In need of a softball bat for that younger player in your life? The Easton FS400 is a great youth option that is ready for play right out of the box. With a one-piece, aluminum alloy construction, this Easton softball bat requires absolutely zero break-in period and is hot out of the wrapper. Easton's 7050 aircraft alloy was used during the construction of this model to deliver a great sound, premium pop, and long lasting durability. Due to the construction, combined with the one-piece design, the FS400 offers a traditional feel with great feedback. Plus, an all sports bat grip comes pre-wrapped around the ultra-thin 29/32 inch handle diameter for an unmatched feel on contact. The best part is the fact that this softball bat is backed with a full twelve (12) month manufacturer's warranty. Easton: Engineered For Glory!
This Easton FS400 Fastpitch Softball Bat (FP16S400) features a standard 2 1/4 inch barrel diameter, a lightweight drop 12 length to weight ratio, and certifications for many different leagues. Whether you're in USSSA, ASA, NSA, ISA, ISF, or SSUSA, this Easton FS400 is approved for play! Pick up yours today with free shipping right here at JustBats.com. Remember, we'll be here for you from click to hit!


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by Don Arthuro
Imperial Domination is a Turn Based Strategy game. The goal of the game is to colonise Africa. Do this by training units, constructing buildings, conquering natives and eliminate the competition. A good strategy and smart diplomacy is required to accomplish this.
Tags: strategy, turn, based, tbs, imperial, domination, simulationDownload
|Rating||3.6 (by 187 users)|

domain: game


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The Election Commission on Saturday issued notice to Congress candidate from Madhya Pradesh's Khandwa, which goes to polls on May 19, for allegedly violating the model code of conduct by distributing and filling-up enrolment forms of the party's proposed "Nyay" scheme.
Arun Subhashchandra Yadav has been asked to furnish an explanation within 24 hours.
An EC statement said: "Prima facie, it shows that the aforesaid act (distribution and filling up of Nyay enrolment forms) has been done by or on behalf of and within knowledge of the contesting candidate of the Congress, Arun Subhashchandra Yadav, from Khandwa."
A Bhartiya Janta Party member had lodged a complaint on May 3, alleging that the Congress is illegally distributing and filling up Nyay scheme enrolment forms, bearing Congress President Rahul Gandhi and Yadav's pictures along with party's symbol, in three districts in Madhya Pradesh.
The state's Chief Electoral Officer, after investigation, concluded that a case is made out against Yadav, as his associate Sudhansingh Thakur distributed the forms in Khandwa district. An FIR was filed against Thakur on May 5.
After examining the documentary evidence against Yadav, the poll panel told him to submit an explanation in the matter within a day, "failing, which the Election Commission shall take a decision without further reference to him".
Under the Nyay scheme, the Congress has promised Rs 72,000 will be deposited yearly in the accounts of poor people, if the party is voted to power.


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I didn’t really know too much about this historic city until I read Elizabeth Kostova’s “The Historian” (highly recommend that book, by the way). Istanbul is a place frequented by the characters and a place I found myself researching after completing the novel. I’ve heard so many fabulous stories about this city from Chloe and other traveling friends and want to check it out for myself.
Ahh, Paris. While Paris may seem a bit overrated, it’s been somewhere I’ve wanted to go since my french-speaking days in high school. I almost took a trip with my french teacher my senior year, but wasn’t able to gather up the funds. Thankfully, I have two friends living near the city so visiting them also gives me the excuse to visit the city of lights and couch surfing makes traveling so much more affordable!
Prague is another city frequently mentions in “The Historian” and filled to the brim with gorgeous architecture and history. The city of a hundred spires offers a breathtaking view and many, many gardens.
The hills are alive with the sound of music! Besides being the filming site of “The Sound of Music,” it’s also Mozart’s ol’ stomping grounds. Salzburg is filled to the brim with art and culture. It would also be great to add the Old City off but my UNESCO list and see the fortress in real life!
Budapest is a bit off the radar for tourism, but it is starting to grow. I have to be honest and say I don’t know too much about this Hungarian city, but I’m interested in learning more of it’s history and culture. So many of my travel friends are recommending it and it just looks stunning in their photographs!
Other options I’m Considering: Zurich & Bern, Switzerland, Warsaw, Poland, Luxembourg City (again), Luxembourg
Ok, so I tried to make the why to visit each of these different, but they all have a similar reason for my I want to visit them – the history. Being in Europe is like walking through a real life museum that somehow captures the past and allows itself to continue to grow and flourish, building new history and culture along the way.
Where are you planning to travel to this year?


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AARP believes family caregivers aren’t celebrated nearly enough. Older parents, spouses and other loved ones can remain in their homes because their caregivers are dedicated to keeping them safe. AARP is fighting for more support, help at home, workplace protections, training, and more.
When you're caring for a family member or another loved one, it is too easy to put your own health on hold. There is relief on the horizon. If you are a family caregiver, the health care law can benefit you and your dependents.
Search AARP States
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This 1957 Chevrolet 150 has undergone a complete professional
frame-off rotisserie restoration. Power comes from a 502ci
big-block V8 engine topped with a Dyers blower tuned for the
street. Power is put to the pavement via a Moser 3.37 rear end, and
the custom Chevy features a box molded frame, coilovers tubular
A-frames and rack & pinion steering. Additional features include
new floors, quarters and glass, as well as remote doors and trunk.
The car rides on Billet Specialties wheels and the interior
includes bucket seats.


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Cheney’s Obama-one-term-presidency delusion
Earl Ofari Hutchinson | 1/25/2011, 8:49 a.m.
Cheney’s war on Obama is about the GOP regaining power, control, political dominance, protecting its corporate and financial interests, its strict construction definition and enforcement of the laws, and more broadly the imposing of its philosophical view of how government should be run. The presidency is the grand prize that pulls the political, economic and philosophical threads on how government and power will be exercised together for the GOP.
It’s not enough for the GOP to win big in the House and gain valuable ground in the Senate as the party did during the November mid-terms. Senate Democrats will still largely march to the president’s tune and will stymie any of the wilder, way out initiatives and pieces of legislation that the Tea Party influenced House will pass to thumb its nose at, embarrass and weaken the Obama administration.
President Obama also has two more big weapons to bolster his administration and re-election chances. That’s the power of the veto which presidents use strategically and effectively against the other party. The other big weapon is the power of the bully pulpit to shape and mold public opinion, and even turn a crisis into a triumph. Obama’s deft use of that to drive home the message of tolerance, unity and civility was on full display in his Tucson speech and appearance.
As other presidents before him, Obama will continue to hear the politically charged three words, “one-term president” said about him by the GOP attack machine in the run-up to the 2012 presidential elections. It comes with the political turf. Cheney knows that, but that doesn’t make it happening any less of a delusion.
Earl Ofari Hutchinson is an author and political analyst.


I finally built my first PC. I was incredibly excited until the first boot - no video signal, my monitor stayed in sleep mode. I hit the reset button - video comes up. I figured it was a fluke.
I shut the PC down at the end of the day. The next morning, I started it up....No video signal...I hit the reset button again - video comes up. This problem occurs on every cold boot.
I have already tried the following:
Disabled onboard video (MB - BIOSTAR TA780G M2+)
Reseated RAM (2GB 6400 G-SKILL)
Reseated Video Card (PCIe - ATI HD3870)
Different RAM (1GB 4200 Kingston)
Reseated Sound Card (PCI - SB AUDIGY 4 Pro)
Checked all power connections (PSU - Rosewill 600W)
Reseated CPU (AMD 5000+ Black Edition)
Checked Casse Power and Reset button Connections
Removed Battery & Cleared CMOS
Tried different cables for video (DVI and VGA)
Seagate 250GB SATA HDD
USB Card Reader
2 Case Fans (120mm)
After going through all that without a fix - I removed the video card, and booted with onboard video - VIDEO! I bought a new video card thinking the video card was busted, but when I installed the new card, the problem has come back!
Any one have any ideas? I don't have access to a ton of parts, or money to buy new parts...
Is this possible: The motherboard doesn't have enough power on the cold boot to start the video card, but it does on a reset, or boot after everything has already run? I read that in a couple of places, but haven't considered the PSU because it was 600w...
I have similar - and I think problem is video card. We are facing a lot of "could-be's", so testing component in known working system seems to be the best approach.
In my case, the video card in another working system produced One Long Beep and Two Short Beeps on cold start. According to the motherboard manufacturer for that system, it meant "bad display".
Since it could be a signal interface problem between the video card and the monitor, I also changed the monitor - and since I got the same result, I have narrowed it down to a problem with the video card.
As the "boot" is the problem, it doesn't involve drivers or utilities which do not load until after initial boot is performed - this is BIOS/system hardware level issue.
My guess is there is a sloppy clock on the video card which needs a jolt to get going in the morning.
I have the same problem with the same MB and CPU. My problem started after adding 2 GB ram and upgrading CPU from 3600. It is strictly a cold boot problem and PC works great rest of the time. Guess I wont change anything until it refuses to start. It appears that the MB doesn't have enough juice to kick in the video. Changed PSU - no change. Good luck.


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NHTSA Investigates Grand Cherokee
July 16, 2001
Filed under Trailer News
The National Highway Traffic Safety Administration (NHTSA) has reportedly received at least
48 complaints of inadvertent rollaway in reverse involving 1995 to 1999 Grand Cherokees.
These incidents led to 32 crashes and 14 injuries, but no deaths have been reported. As a
result, NHTSA is opening an investigation that could lead to a recall. About 1.3 million of
the Grand Cherokees are affected.


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Four New Adaptations from Kirkus Reviews’ Book to Screen
This week at Kirkus, the legendary book review site, their Book to Screen column ran a feature on four very different upcoming book adaptations for the small screen, literary miniseries that range from mystery to YA to historical, all of which will air in July. Kirkus also reviewed each of these titles when they were first published, so be sure to check out the links included in the Book to Screen roundups.
The AMC+ series,The Beast Must Die, premieres July 5, and is based on the 1938 crime novel by the English poet Cecil Day-Lewis (father of Daniel), who wrote the series of detective novels under the pseudonym Nicholas Blake to generate the income his poetry did not. There were nineteen Nigel Strangeways novels, as they were called, and the success of the series enabled Day-Lewis to continue writing poetry. The six-part series stars Billy Howle ((Star Wars: The Rise of Skywalker) as detective Strangeways, and re-envisions the original character of Frank Cairnes as Frances, played by the English actress Cush Jumbo (The Good Wife and spinoff The Good Fight). In episode one, Frances’ son is killed in a hit-and-run, and when she discovers the man she believes was behind the wheel, played by Mad Men’s Jared Harris, she plots his murder. The series is directed by Tolkien’s Dome Karukoski.
Cecil Day-Lewis published a dozen poetry collections, three collections of essays, and numerous translations, novels, and children’s books. A professor of poetry at Cambridge and Oxford, he received the CBE from George V in 1950, and was named Poet Laureate of Britain in 1968. He died in 1992, and is buried in the cemetery at Stinsford in Dorset, near the resting place of his literary hero, Thomas Hardy.
Coming July 8 from HBO Max, Gossip Girl, a series based on the 2002 YA novel by Cecily Von Ziegesar. Gossip Girl has previously taken form as a televised series, in 2007 on CW TV, and the latest incarnation picks up where the previous series left off, following the privileged Upper East Side adolescents at the exclusive Constance Billard private school. The HBO Max series updates the storyline with an anonymous Instagram account (@GossipGirl) that spies on the students and sows discord in the pecking order of influential adolescents. There’s also a new cast, including Doctor Sleep’s Emily Alyn Lind, along with a member of the original cast. The Good Place’s Kristen Bell lends a familiar voiceover as the titular narrator.
Cecily von Ziegesar was born into an aristocratic German family and grew up in New York. Like her Gossip Girl characters, she attended an exclusive Upper East Side prep academy, The Nightingale-Bamford School, and was a serious student of ballet before studying creative writing. The Gossip Girl series was among The New York Times bestsellers list in 2002. A follow-up series, The It Girl, was a bestseller in 2005.
This July 9, Netflix will air the Season 3 premier of Virgin River, based on Robyn Carr’s bestselling 21-novel series of the same name. Searching for a fresh start, the widowed nurse practitioner Melinda Monroe moves from LA to a remote northern California town looking to start over. Depictions of small towns typically feature a cast of quirky characters, and Virgin River’s include Annette O’Toole (Nash Bridges, Smallville) as the town’s mayor, Tim Matheson as the local doctor, and a romantic interest in a military veteran played by Jack Sheridan (Grey’s Anatomy). Catch up with the previous two seasons, both of which are available on Netflix.
Robyn Carr began writing as a young mother in 1970, and has since published almost fifty novels. The Virgin River series was her first, and eleven of her novels New York Times bestsellers.
Nancy Mitford fans will have to wait until July 30 for Amazon Prime’s newest series, The Pursuit of Love. The series is based on Mitford’s enduringly popular novel, The Pursuit of Love, published in 1946, which follows the Radletts. Set in the inter-war period in England, the novel is based on Mitford’s own eccentric and privileged family. Told from the point of view of a cousin, Fanny (Cruella’s Emily Beecham) who’s come to stay at Alconleigh, the Gloucestershire estate, we’re introduced to the bored, pleasure-seeking sister, Linda (played by The Dig’s Lily James). Linda’s series of exhilarating and tragic romances include an engagement to a Scottish aristocrat, marriages to Tory politician and a Communist, and a French duke named Fabrice. Andrew Scott, the hot priest of Fleabag fame, plays the glamorous and racy Lord Merlin.
Mitford was the eldest of six sisters—Jessica, Diana, Unity, Pamela, Deborah, and Nancy—who together were known as bright young things of the nineteen twenties and whose influence was far-reaching in the social sets of inter-war Europe and the US. An aristocratic autodidact, Mitford was the author of novels, biographies, and translations, and especially her fiction contained a trademark wit and satiric tone that ran against the grain of her upper-crust upbringing. Her writing began as a means to supplement the limited allowance from her family, and in time she gravitated to politics, and while her leanings were considered moderately socialist, her body of work held close to the upper-class values she grew up with. At the end of World War 2, Mitford moved to Paris, and spent her final years in Versailles, writing, receiving a CBE from Queen Elizabeth, and publishing her final book, a biography of Frederick the Great, in 1970. Mitford died in London in 1973.
The Pursuit of Love is written and directed by British character actress Emily Mortimer (The Newsroom and The Perfect Girl in Notting Hill, among others), and marks her directorial debut. In this series, Mortimer also plays the juicy role of “Bolter,” Fanny’s flighty mother, named for her preferred method of ending love affairs. Read Mortimer’s thoughts on her character, and her project, here.

domain: library


Our mission is to train scientists. This blog is a platform for us to share updates on our annual programme, tips and tricks for scientists, new e-learning opportunities, and sometimes just something to make you smile.
Current capabilities and applications of AI in the field of structural biology and biophysics
Written by event reporter Ahmed Adel Ezat
The past decade has witnessed several trials to apply artificial intelligence (AI) techniques such as deep learning (DL), to solve grand challenges in the field of structural biology and biophysics of biomolecules. One of these challenges is the protein folding problem. These efforts have culminated in a new breakthrough in the field of structural bioinformatics called AlphaFold, developed by Google DeepMind, and published in 2021 for the scientific community.
AlphaFold solves half of the protein folding problem which is predicting the native 3D structure of proteins with a nearly experimental accuracy. It leverages the co-evolutionary information encoded in multiple sequence alignment (MSA) to predict the native structure of monomeric proteins.
The AlphaFold breakthrough drove forward computational and experimental structural biologists and biophysicists to organize workshops and conferences to discuss the potential pros and cons of AI applications in structural biology and bioinformatics and how they can harness its power to accelerate the structure determination of proteins and their complexes.
Two EMBO workshops have been organised in 2021 and 2022 to meet such aim. The 2023 edition ‘Computational structural biology’ just took place at the beginning of December in Heidelberg.
I am Ahmed Adel Ezat, Lecturer at Biophysics Department, Faculty of Science, Cairo University and I was so lucky and proud to attend all these workshops and be updated with the different applications and new advancements of AI in structural biology and biophysics. I was very keen to take part in such a meeting to be acquainted with the current capabilities and applications of AI in the field of structural biology and biophysics and what are its new frontiers and perspectives and how do other experts in the field think of it in the future?
The recent workshop discusses the AI revolution in the field of structural biology from the structure determination of proteins and nucleic acids and their complexes, structure- based function annotation, the prediction of mutations effect on of protein structure and function to the integrative modeling of large supercomplexes of the cell and even whole cell dynamical modeling.
I am very thankful to EMBL to give me the opportunity to attend as an event reporter. It was a very nice experience for me.
Briefly, I will highlight the key five takeaway messages from the meeting.
AI still revolutionises the structure determination of proteins, RNA and their complexes:
The correct cellular functioning depends on the binding of different biomolecules, such as proteins, peptides and nucleic acids, with other proteins. Most of these interactions are transient and the experimental modeling of such complexes is challenging.
The current advancements of AI assisted modeling of proteins (AlphaFold and RoseTTAFold) helped to predict the protein – protein and protein – peptide interactions (PPI) and start to build the human cellular proteome and their interaction networks.
As an acknowledgement of their contributions to the AI revolution of protein structure determination, John Jumper, AlphaFold developer, and Minkyung Baek, RoseTTAFold developer, presented the state of the art of their software and their new capabilities and potential improvements in the future.
John Jumper presented the evolution of AlphaFold versions and what has been built on it till now from the modeling of protein monomers to the accurate prediction of larger multimeric proteins (AlphaFold Multimer) and prediction of sequence variation impact on protein structure (AlphaMissense).
Baek highlighted the current state and improvements of RoseTTAFold and its performance with respect to AlphaFold2 and other AI assisted protein modeling software. She showed the current power of AI in predicting protein – nucleic acids complexes through RoseTTAFoldNA.
Several groups showed their contributions to improve AI assisted modeling of proteins through building neural network energy models based on co-evolution information and biophysics laws for accurate modeling and design of proteins.
The accurate modeling of RNA 3D structure is a challenging problem in the computational structural biology field due to its high flexibility and dynamics.
Two groups presented their current advances in RNA 3D modeling through integration of experimental data such as solid-state mass spectroscopy at Cryo temperatures, electron microscopy and chemical probing with molecular modeling and simulations.
Others shed the light on the power of machine learning and protein language models to improve the modeling accuracy of protein – protein interactions and applied them to antigen – antibody complex prediction and T- cells’ receptors (TCR) recognition of diverse antigenic proteins.
Computational microscope with adjusted temporal and spatial resolutions:
Computational microscopy, a term coined by Klaus Schulten several years ago, to demonstrate the power of molecular dynamics simulations to describe the biomolecular structural dynamics at different temporal and spatial resolutions.
The adjustment of the spatial (Atomistic, Coarse Grained, ML/MM and QM/MM) and temporal (from femtoseconds to milliseconds) resolutions of biomolecules allowed different researchers to study complex cellular processes thanks to the current developments in both hardware and software.
Several research groups showcased different applications such as SARS – CoV2 spike interaction with cellular receptors, mitochondrial membrane bending by large supercomplexes “electron transport chains (ETC)”, specific binding of Cas9 from different species to CRISPR, antibiotic and drug resistance through non-equilibrium molecular simulations, the investigation of association and dissociation mechanisms of protein – protein interaction and the integrative modeling of monomeric proteins by combining molecular dynamic simulations with other experimental techniques.
AI is a new pillar in the accurate structure – based function annotation and analysis:
The correct prediction of proteins’ function requires the accurate modeling of protein structure and dynamics. Thanks to the AI revolution of structure modeling, we can solve the structure of monomeric and multimeric proteins within a few minutes.
AI models (machine learning and protein language) can be trained based on sequence and structure features to predict proteins’ function.
Several research groups presented their different methods to extract features and build models to solve specific problems such as building a catalogue of enzymes to study and predict enzyme evolution and mechanism, selectivity and specificity of G – protein coupled receptors (GPCRs), functional annotation of microbial proteins to understand their microbiome – phenotype relationships.
The future is structural systems biology and spatiotemporal mapping of the entire cell:
The combination of diverse information from multiple experimental and computational techniques aids in the modeling of large supercomplexes of the cell such as proteasomes and nuclear pore complexes containing thousands of proteins. AlphaFold predicted monomers and multimers accelerate such modeling processes. Thus, Integrative modeling is revolutionizing cellular biology and biophysics and mapping the entire cell at different spatial and temporal scales. It adds new molecular, kinetic and dynamical details to our description of cellular processes.
Several groups showed that combination of experiments, such as cryo-EM, cryo-ET, and mass spectrometry (MS) with AI predictions (AlphaFold) increases the confidence of modeled complexes and larger assemblies can be built based on them.
Two groups integrated AlphaFold models with low resolution data inferred from cryo-EM and mass spectrometry (MS) to give molecular details of eIF2 dephosphorylation macromolecular complex and the native architecture of motile cilia.
Another two research groups harnessed the power of deep learning models to predict binding sites and localize intrinsically disordered regions (IDR) in large assemblies and visualize protein-protein interactions and interfaces inside cells at near atomic resolution.
Two more research groups presented their work on modeling the conformational dynamics of proteins and their complexes in solution from Hydrogen-Deuterium Exchange mass-spectrometry (HDX-MS) and the automatic and precise modeling of water molecules in multiconformer protein – ligand models solved from high resolution x-ray maps.
To address the problems of integrative modeling, Andrej Sali presented an approach to deal with them. This approach combines several input models, built from different data, to get a more accurate output model of the structure of interest. This process is called metamodeling.
Zaida Luthey-Schulten constructed a dynamical 3D whole – cell model via integrating structural details with kinetic measurements and other experimental data to simulate a growing minimal cell and visualize cellular processes in action.
AI diversely contributes to structural biology:
AI can aid not only in modeling structure of proteins and their complexes but also in learning complex physical rules of protein – ligand binding, predicting protein – membrane interfaces, predicting effects of mutations and designing new functional proteins and ligands.
One group presented their attempts to design deep learning-based scoring function trained to learn the protein – ligand interactions and showed its performance in identifying important binding interactions.
Another groups presented the capabilities of deep learning based models to predict protein – membrane interfaces and effects of mutations on protein structure and function and their relations to various diseases.
Others presented their efforts to design new protein functionalities using deep learning methods and how these methods are developed to design new sequences that are predicted to fold to specific structures and perform functions of interest.
Finally, I wish to say that the field is rapidly growing and that “Cambrian explosion” of AI applications in every aspects of structural biology requires the organization of frequent discussion meetings to present the current state and future trends in this field.
The scientific organisers are planning to organise workshops with this topic frequently and the next version will likely be in 2025.


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Can PTSD Be Cured?
What is PTSD? Post-traumatic stress disorder (PTSD) is a mental health condition that can develop after a person experiences or witnesses a traumatic event, such as a natural disaster, combat, sexual assault, or a severe accident. The symptoms of PTSD can be debilitating, and they can include intrusive thoughts, flashbacks, avoidance behavior, and heightened anxiety. […]
Chronic Pain and PTSD
Chronic pain and PTSD can be two very debilitating conditions. They can often intersect, making life even more difficult for the person suffering from them.
The Struggles of Executive Functioning When OCD Is Present
People with OCD have various impaired cognitive functions that may include executive functioning. OCD and executive functioning issues often appear with the presence of one or both avoidance or anxious behaviors. In examining neuroimaging data, there seems to be a correlation between OCD and the areas of the brain that handle executive function.
Is OCD Common?
Skipping a family birthday party to clean your kitchen for the second time that day or being preoccupied with how canned food is stocked in the pantry could be signs of a mental health condition known as obsessive-compulsive disorder. It’s a serious condition if ignored, but the symptoms are treatable.
Is Anxiety Related to Insomnia?
You’re tense, agitated, have low energy, suffer from rampant moodiness, and have trouble getting restful sleep. What’s going on? Any number of conditions could be affecting your quality of life, but a logical explanation could be the nexus of anxiety and insomnia – two illnesses that can lead to the other.
What is PTSD?
If you’re a military veteran who survived a combat situation, it may be normal to experience flashbacks or nightmares afterward. But if you’re an average person – teacher, office worker, truck driver – you, too, can experience a PTSD attack. The symptoms may differ for everyone but can often be treated following a medical diagnosis.
Anxiety and Breathing
You had a spirited disagreement with a co-worker and noticed your heartbeat was racing afterward. The following day, you woke up exhausted because you couldn’t sleep. These can be chalked up to everyday anxiety, or they could be symptomatic of something worse – an anxiety disorder slowly taking over your life.
How To Stop Anxiety
Momentary anxiety is not just normal – it is an important evolutionary tool. It is our body’s way of letting us know that we may be in danger. Some people have feelings of anxiety and stress that go far above normal levels – these are anxiety disorders.
Can OCD Be Cured?
Like all other mental health conditions, OCD does not have a known cure at this time. That said, there are treatments and forms of therapy that help alleviate the symptoms and bring you to a place of mindfulness and acceptance.
CRPS Types 1 And 2 and How You Can Find Treatment
Complex Regional Pain Syndrome Complex Regional Pain Syndrome (CRPS) is a chronic neuro-inflammatory disorder that typically affects one specific limb after an injury, believed to be caused by damage to the nervous system. The pain is usually out of proportion when compared to the initial injury. Often, the initial energy is a musculoskeletal or nerve […]


August 21, 2016
Coco Peila is one of Hip Hop musicians in the new class that is creating the new Bay Area sound. After being affiliated with Sandman of the Oakland-based Attik crew back in the day, Coco Peila is standing on her own two feet and spreading her wings. Her summer and fall is filled with an album, a mixtape, a video and multiple collaborations. Check her out in this exclusive interview.


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More 5-Day Spain Tour Seville Cordoba Toledo Ronda Costa del Sol and Granada from Madrid Info
Take your time with five days to explore some of Spain's most famous cities. With Moorish Kingdoms in Granada, thriving resorts of the Costa del Sol, and the many UNESCO World Heritage sites in Cordoba, Seville and Toledo, this is a tour deep into the heart of Andalucia.
Next Tour - Flamenco and Spanish Dance at Florida Park - Ole, ole! Feel the fiery heat of the flamenco in historic Florida Park on a night out in Madrid to remember. Before the professionals take to the stage you can get up and dance with the orchestra before the show begins. You also have the option of enjoying a traditional tapas meal, a three-course dinner or simply ordering a drink to enjoy while watching the show.
Previous Tour - 4-Day Spain Tour Cordoba Seville and Granada from Madrid Tours List
Grand Hotel & Lucky
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White Bean Zucchini Enchiladas
These white bean enchiladas are packed with fresh garden vegetables then smothered in delicious salsa verde!
Servings8 large enchiladas
- 1 small onion
- 2 medium zucchini
- 2 tomatoes
- 2 fire-roasted red bell peppers (or 1 fresh bell pepper)
- 1 cup sweet corn, cooked (frozen, canned, fire-roasted, etc.)
- 15 oz. can white beans (I use cannellini)
- 2 cups fresh spinach
- 2 tsp. ground cumin
- 1 1/2 tsp. garlic powder
- 8 large tortillas*
- 16 oz. salsa verde/tomatillo salsa (I use mild)
- Optional: vegan shredded cheese, nutritional yeast
- Fresh cilantro, green onion, avocado, tomato, corn, etc.
Preheat oven to 350°F (176°C).
Dice onion, zucchini, tomatoes (excess juice removed), and roasted bell peppers.
In a large skillet over med-high heat, sauté onion for 5-6 minutes. (I use 3 Tbsp. water/broth for no-oil sauté method, adding more liquid as needed.)
Add cumin and garlic powder. Sauté 1 minute.
Add zucchini, tomato, pepper, and corn. Stir and sauté 6 minutes, or until zucchini is tender.
Rinse and drain white beans. Add to skillet.
Roughly chop spinach and add to skillet. Stir and cook for 2 minutes. Salt/pepper mixture to taste if desired. Turn off stove.
Distribute the bean mixture evenly down the center of each tortilla. Top with a sprinkle of vegan shredded cheese or nutritional yeast (optional). Then roll up tightly, tucking in both ends.
Place enchiladas seam side down in a 9×13" pan. Evenly coat the top with salsa verde.
Place in oven and bake for 25 minutes.
*I use large burrito-sized tortillas. Made gluten-free with your favorite GF tortillas.
Corn tortillas are also a delicious GF/oil-free option. You’ll need about 12-16 tortillas. However, you may want to turn it into an enchilada casserole and layer/stack the filling & tortillas for easier assembly.
Calories: 317 kcalCarbohydrates: 55 gProtein: 11 gFat: 6 gSaturated Fat: 1 gPotassium: 799 mgFiber: 6 gSugar: 10 gVitamin A: 1526 IUVitamin C: 24 mgCalcium: 139 mgIron: 5 mg


text:
Through the photographer's lens, through the director's lens
Loves: The Criterion Collection, photography
Likes: Michelangelo Antonioni, surrealism
Dislikes: Extreme vagueness, modeling, fashion
Hates: Disappointing endings
Thomas, a fashion photographer (David Hemmings), is introduced through two studio shoots--one a seductively intimate session with the slinky Verushka, the other with an aggressively controlled group of models he berates as he photographs. Who Thomas is when interacting with others is suggested at through these moments, but the real man emerges over the course of the rest of the film as he finds himself wound into a peculiar situation, as he casually photographs a couple enjoying time together in the park, and ends up as the possible witness to murder, with Jane (Vanessa Redgrave), the woman in the park, trying to get the pictures from him, for reasons that are unclear.
On the whole, the film is most likely about reality and how it can be manipulated, with Thomas' attempts to understand what he thinks he saw through the process of enlarging his photos again and again, serving as a key metaphor: the closer he looks, the less clear the picture is. That sense of a reality shifting and changing is evoked repeatedly throughout the film, in small, subtle ways that are easy to miss (rewarding multiple viewings) and in far more obvious moments, like the fillm's famous (or, depending on your opinion, infamous) final scene, which offers no answers to the film's mystery, in a scene that's the epitome of a 1960s art film.
Blow-Up leaves its cast without much to say for large portions of the film. Truly, the majority of the most memorable moments, including the photography process that lends the film its name and a romp between the lead and two young women that gave the movie its infamy, thanks to envelope-busting nudity, were dialogue-free. That doesn't mean there aren't some solid performances, as Hemmings is quite good at portraying Thomas' shifting moods, not to mention his spiral as the film moves forward, while Redgrave is believably inscrutable as the woman of questionable motives at the center of it all.
To enjoy or even just appreciate Blow-Up doesn't require a deep understanding of the concept of mediality or the mental feat of piecing together of story elements that aren't there (but which may have been at an early point in production), but rather just an acceptance of the film as an exercise in the power of aesthetics in filmmaking. Everything looks and sounds a very precise way, but lives in the mind of the beholder, not unlike the effect of a beloved painting which hangs on the wall, but does much more in the brain. Antonioni manipulated the medium and put his beautiful creation before us to enjoy, taking from it whatever we may see in the brushstrokes.
There are three key elements to Blow-Up in regards to the LPCM 1.0 track on this disc, and that the music, the environmentals and the sound effects, and all three sound terrific, along with the dialogue, which is clear and strong. The music, featuring jazzy instrumentals by Herbie Hancock and rock from The Yardbirds, is well separated from the other elements and crisp, while the environmentals and sound effects, which play a large role in the plot, are appropriately weighted in the mix. This disc captures the feel of the audio as it should be.
Blow Up of Blow-Up (53:53) is a new short documentary by Valentina Agostinis about the film, featuring interviews with a number of experts and people who were a part of the production. Covering a variety of topics connected to the film, the piece puts Blow-Up in the context of its time and visits some of the locations used for shooting, while sharing plenty of on-set tales, including Antonioni's role in the formation of Led Zeppelin. Well-made and loaded with good info, it's an enjoyable watch for fans of the film or its maker.
Two interviews with Hemmings--one short and one long--offer a peek into who he was as an actor and a person. The first (5:23), from 1968 and shot on the set of a film he was making, hears him talk about London and his preference for New York City, while sharing some thoughts on his Blow-Up character, while the the other (20:18), from a 1977 show called City Lights, gets more in-depth into the experience of a newly-successful actor in Hollywood. Combined, the two clips reveal the candid, intriguing man behind the role of Thomas.
Another interview, this time with Redgrave (44:44), was part of a series called "In Conversation", and took place in 2016 with historian Philippe Garner. Presented in black and white, it covers what it was like for the actress to work with Antonioni, her thoughts on film nudity and some of her humanitarian interests as well. At times, there are some issues of over-talking between the host and guest, as they aren't always in sync, but overall it's an interesting chat.
A final interview (8:53)--an excerpt from a 1989 sit-down with Jane Birkin, who played one of the two girls in the studio--is possibly the most interesting of the bunch, as she talks about auditioning, Antonioni and the controversy surrounding her nudity in the film. The most memorable moment of this clip however is when she talks about her life as a housewife, which is just a brutally miserable story.
A critical perspective on the film--"Antonioni's Hypnotic Vision"--is made up of two parts, "Modernism" (16:06) and "Photography" (29:49). In "Modernism", David Alan Mellor, curator and art historian at the University of Sussex looks at the influence of modernism in art on Antonioni's film (including the presence of modernist art in Blow-Up), while in the other, historian Philippe Garner and Walter Moser, head of the photographic collection at the Albertina museum in Vienna talk about his exploration of photography. Between the three, you're granted a better understanding of the importance of these topics in the movie and their presence and influence on the themes of Blow-Up, with a number of subtle references laid out plainly.
Wrapping up the on-disc extras are the film's trailer (2:14), which sells the movie on prurient interest and Antonioni's reputation, while the teaser (1:01) offers a cut-down version of the trailer, made entirely of still photos (recalling a scene in the film.)
As is the norm for Criterion, there's a printed pack-in, but unlike the usual brochure, this time you get a hefty 68-page, perfect-bound book that's gorgeously designed in red, white and black, and illustrated with images from the film. The length allows it to hold an informative essay by author and NYU Contemporary Italian Studies professor David Forgacs, a chapter from Stig Bjorkman's upcoming Antonioni book (with details from his time on the Blow-Up, the questionnaires Antonioni used to get to know photographers and artists in preparation for the film and the short story by Julio Cortazar, so you can see where the film got its start (and how different it ended up. This wealth of insight makes for a terrific package.
The Bottom Line


Volume 1 & Volume 2 (3LP)
A fantastic, hypnotic and funky compilation from the Dur-Dur Band of Somalia! This triple LP reissue of the band’s first two albums -the first installment in a three-part series dedicated to Dur-Dur Band- represents the first fruit of Analog Africa’s long labours to bring this extraordinary music to the wider world. Remastered from the best available audio sources, these songs have never sounded better. Some thirty years after they first made such a splash in the Mogadishu scene, they have been freed from the wobble and tape-hiss of second and third generation cassette dubs, to reveal a glorious mix of polychromatic organs, nightclub-ready rhythms and hauntingly soulful vocals. In addition to two previously unreleased tracks, the music is accompanied by extensive liner notes, featuring interviews with original band members, documenting a forgotten chapter of Somalia’s cultural history. Before the upheaval in the 1990s that turned Somalia into a warzone, Mogadishu, the white pearl of the Indian Ocean, had been one of the jewels of eastern Africa, a modern paradise of culture and commerce. In the music of the Dur-Dur band -now widely available outside of Somalia- we can still catch a fleeting glimpse of that golden age.


This decision is not final until disposition of timely filed motion for rehearing .
Appeal from the Circuit Court for the Seventeenth Judicial Circuit, Broward County; Martin Bidwill, Judge; L.T. Case No. 09-574CF10A.
Carey Haughwout, Public Defender, and John Pauly, Assistant Public Defender, West Palm Beach, for appellant.
Pamela Jo Bondi, Attorney General, Tallahassee, and Mitchell A. Egber, Assistant Attorney General, West Palm Beach, for appellee.
GROSS, CIKLIN and LEVINE, JJ., ...