The conditioning filter a single of the of essentially the most important cooling parts inside of the air conditioning system. Without it, your air conditioning system is often dirty and the air you breathe is going to be filled with pollutants. All air conditioning parts, against the ductwork towards the air conditioning refrigerant, require the air conditioning filter to be clean and replaced to ensure you’re having the very finest in central air conditioning.
If an aura conditioning filter is left dirty, over time, may perhaps possibly lead to increase energy costs and short
equipment life due to all the air-con parts turning to each other useful. One can perform without the additional. Overall, your heating and cooling won’t be as effective additionally will reason to invest in many air conditioning repair and air conditioning maintenance.
An ac filter ought to changed each and every month or every two months for home heating and cooling systems and couple of weeks for several commercial or industrial air conditioner since it’s running almost 24 hours a day, 7 days a week. Doing this to be a routine in your monthly chores and not waiting till you see dust matted on the air conditioning filter be sure you along family the very best health as well as an even running air conditioning system also. Dust particles just can’t always be observed so whether or not you the little dust on the air filter , clean it as you normally would.
Since a few obvious methods a associated with air conditioning filters , how quickly one gets blocked versus another hinges on the brand – most air conditioning filters are sized 1 to two square feet for each ton of capacity to have home or commercial assets.
You can judge a filter’s capability to clean by way of MERV ratings – Minimum Efficiency Reporting Value – which is often a rating of how efficient an aura conditioning filter is from 1-12. Superior terms you get the rating, the far better it was a student in removing particles such as animal dander, pollen, dust, mold as well allergens, as well as the better the security for your air conditioning equipment . Most air conditioning filters screen out particles measuring from three to 10 microns in proportions.
When placing the appropriate air conditioning filter within the system, the filter should be placed in right direction as indicated by the arrow situated on the side or face of the filter. Air should flow in the correct direction and also in identical shoes direction when the arrows. Up-to-date the filter to work appropriately, becoming air exits the filter in probably the most reinforced a part of the sieve.
The air conditioner filter should fit properly. A perfect seal is forced to prevent unfiltered air from entering and damaging your air conditioning system. With perfect seal and appropriate sizing, the filter is useless. Additionally, the non-conventional filters may have a higher efficiency as well as not fit your system. Folks be checked with an air conditioning company, contractor, or air conditioning supply lender.
Lee Services AC and Heat LLC
8270 Woodland Center Blvd, Tampa, FL 33614


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Five nursing homes have been fined by the state Department of Public Health (DPH) for errors that endangered or injured residents.
Regency House Nursing and Rehabilitation Center of Wallingford was fined $10,000 for two violations.
On Sept. 14, 2018, a resident suffered a calf laceration that needed 10 sutures after a wheelchair rolled into a bed frame. A nurse aide wheeled the resident in front of a bathroom door and walked to a dresser to get a comb when the wheelchair continued to roll. According to DPH, the nurse aide was re-educated on the importance of wheelchair brakes.
On Aug. 7, 2018, a resident had swollen cheeks along with white patches on the left cheek and gum line, according to DPH. An investigation found that in the days leading up to then, the resident erroneously received 11 extra doses of methotrexate, which is used to treat rheumatoid arthritis. The resident should have received 10 milligrams per week of methotrexate, but a registered nurse mistakenly transcribed the order as 10 milligrams per day.
The resident was treated for methotrexate toxicity and transferred to a hospital Aug. 13, 2018, for a platelet transfusion. Following the incident, all methotrexate orders at the facility were to be flagged with an alert, according to the citation.
Ridge Crest at Meadow Ridge in Redding was fined $9,060 after a resident developed gangrene and needed an above-the-knee amputation.
The resident was admitted to the facility June 13, 2017, following an operation at a hospital for a right leg ulcer. Staff failed to conduct weekly wound assessments between June 13 and Sept. 4, 2017. Staff also failed to assess the resident’s circulation between June 13 and Sept. 26, 2017, according to DPH.
The resident was taken to a hospital Sept. 26, 2017, diagnosed with gangrene and had the amputation. In addition to other errors, staff failed to properly notify physicians of changes in the resident’s condition, according to DPH. Following the incident, the facility submitted a corrective action plan to DPH that includes skin assessments for all residents.
The violation was a “single and isolated” incident, said spokeswoman Jennifer Whittle.
“We continue to be dedicated to providing the highest standards of care at Ridge Crest at Meadow Ridge,” she said.
Apple Rehab Coccomo in Meriden was fined $6,120 after a resident fell while being transferred.
A nurse aide tried to move the resident from a wheelchair to a toilet without help, even though the resident’s care plan called for two-staff assistance with all transfers. The resident fell and was taken to a hospital, according to DPH.
The resident was diagnosed with fractures of the tibias, fibulas and left humerus. According to the citation, the nurse aide transferred the resident without help and didn’t use a gait belt. The nurse aide had moved the resident alone earlier in the day without a problem, and didn’t check the resident’s care card for transfer instructions. The nurse aide was terminated for twice failing to follow the plan of care, according to DPH.
Meridian Manor Corp. in Waterbury was fined $3,000 after a resident who was prohibited from leaving independently continued to do so repeatedly.
The resident previously had been allowed to take leaves of absence independently with a car, but on April 26, 2017, an advanced practice registered nurse determined the resident could no longer do so because the resident had low blood sugar, declining renal function, had become hostile, was returning late from leaves, and had missed medications and treatments, according to DPH.
A leave of absence sign-out book showed the resident left the facility independently, almost daily, from May 3 to May 21, 2017. On one trip, the resident obtained a prescription for Oxycodone at a walk-in clinic in the community. On June 1, 2017 the resident signed out for a leave, fell at a family member’s house and suffered facial bruises and skin tears.
The resident continued to leave the facility, according to the citation. On June 16, 2017 the resident was admitted to a hospital and diagnosed with congestive heart failure. Following the incident, the facility implemented a corrective action plan that included educating all licensed staff, according to DPH.
The Hebrew Center for Health and Rehabilitation in West Hartford was fined $1,320 after a resident was sent on a leave of absence with another resident’s medications. The resident was diagnosed with hypoglycemia and treated with intravenous fluids at a hospital on Dec. 24, 2018, according to DPH.
An investigation found that the resident had been sent home on a leave of absence three days earlier with the resident’s medications, as well as several medications intended for another resident. As a result, the resident received an extra dose of Losartan, which is used to lower the risk of strokes in patients with high blood pressure; aspirin; and diabetes medication Januvia, according to the citation.
Officials at the Regency House, Apple Rehab Coccomo, Meridian Manor and the Hebrew Center, did not return calls seeking comments.

domain: news


text: Since my first visit in Dessau I have been fascinated with ”Bauhaus“ architecture. Dessau is an industrial city in the German federal state of Saxony-Anhalt, famous for its UNESCO world heritage ”Bauhaus“ buildings. Here the ”Bauhaus“ school of arts has left behind its most famous buildings. The school was founded 1919 by Walter Gropius in Weimar. In 1925 they moved to Dessau and from there, for their last period from 1932-1933 to Berlin, where the school was finally shut down by the Nazis. Among all art trends and art periods of the last centuries, ”Bauhaus“ may be the one with the strongest impact on our contemporary urban environment. ”Bauhaus“ was based on modernism and proclaimed a radical stylistic change, which opposed against the aesthetics of historism with all its reproductions of earlier ornamentic styles. ”Bauhaus“ artists created architecture, furniture, kitchenware, paintings and photography. Besides Walter Gropius himself, famous ”Bauhaus“ masters living in Dessau were Lyonel Feininger, Lazlo Moholy-Nagy, Oskar Schlemmer, Georg Muche, Paul Klee and Wassily Kandinsky. During their few years in Dessau they resided in the four master’s houses created by Gropius and built in the typical ”Bauhaus“ style, in vicinity to the famous modern school building. Characteristic features are a functional style, an overall cubical form with flat roofs, plain-colored surfaces, and large windows. The latter often connect the interior with the outer balconies and terraces. Among the master’s houses the ones of Gropius and Moholy-Nagy were destroyed in WWII bombings. The surviving buildings were left in declining condition during the four GDR decades, and were restored only in 1990. In 2013 the two destroyed houses of Gropius and Moholy-Nagy were reconstructed in a modern way, but in agreement with the original style. They were opened to the public in May 2014 and the architects David Chipperfield and the bureau of Bruno-Fioretti-Marquez in Berlin had done a fabulous job. In my photo series I have tried to capture the austere functionality of the ”Bauhaus“ architectural style, both in the school building and the old and new master’s houses in clear, photographic compositions.

domain: history


text:
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Page 1 of 2
Did you know that the lung cancer ribbon is a powerful symbol of hope, strength, and unity in the fight against one of the deadliest forms of cancer? In this blog post, we’ll explore the meaning behind the lung cancer ribbon, its significance in raising awareness, and how it helps break down the.
What is the Children's Cancer Symbol? The symbol used for Childhood cancer is the Gold Childhood Cancer ribbon. On occasion, childhood cancer may also be represented by a yellow-gold or yellow ribbon, though it currently shares that particular cancer ribbon color with general cancer awareness. The.
What Cancer Ribbon is Light Blue? Light Blue ribbons represent prostate cancer awareness. The use of Light Blue for the Prostate Cancer ribbon dates back to the early 1990s and has been used to raise awareness for prostate cancer ever since.
What color ribbon is for Bladder Cancer? Bladder Cancer is represented by the unique split blue, purple, and yellow ribbon.
What color is for brain tumor awareness? When it comes to raising awareness for brain cancer, the color gray is a symbol of hope and support. Brain tumors can be benign or malignant, and they can occur in many different parts of the brain, affecting the body's functions and causing a range of.
The Meaning of the Black Ribbon The black ribbon is a multifaceted symbol of mourning, respect, and remembrance, often worn to honor those we've lost. This article sheds light on its importance in the context of skin cancer, while acknowledging its broader symbolism in representing various causes.

domain: medical


text:
(1) In culture filtrates of Cl. chauvoei two antigens have been
demonstrated (a) a toxin, and (b) a heat stable antigen. The toxin
can best be demonstrated by injecting filtrate intradermically into
guinea-pigs, particularly if adrenalin is incorporated in the filtrate.
The presence of the heat stable antigen is proved if toxin-free
(heated) bacilli are injected into sheep; after a suitable interval
these are immune to the inoculation of living culture.
(2) The toxin, or its atoxic modification, stimulates the formation
of antitoxin when injected into animals, whereas the heat stable
antigen does not do so.
(3) The toxin is neutralizable by homologous antitoxin, by
Cl. septicum antitoxin and to a slight extent by the sera of some
normal bovines and rabbits.
(4) The toxins of four different strains of Cl. chauvoei have
been found to be indistinguishable serologically.
(5) There is no correlation between the amount of circulating
antitoxin in an animal and the power of the animal to resist the
inoculation of living culture.
(6) There is a correlation between the amount of circulating
antitoxin in an animal and its power of resisting toxin, injected
intravenously or intradermically.
(7) The evidence points to the heat stable antigen being the
important one in the production of immunity to Cl. chauvoei culture.

domain: biology


Bladed weapons are frequently encountered in violent crime offences including street based and armed robberies, murder, sexual assaults and terrorism.A study was conducted involving four frequently encountered clothing fabrics: t-shirt (knitted cotton), denim jeans (twill woven cotton), long sleeved top (knitted synthetic blend), and skirt (non-woven faux leather) and five knives to investigate any damage resulting from a downward stabbing motion, with 300 stabs in total. Any resultant penetrating severance damage was then photographed, measured and analysed. Statistical analysis revealed significant differences between the stab hole size and shape, as a consequence of the design of a bladed weapon (in particular, the tip shape) that caused it. There is a notable correlation between the Assure knife (rounded tip) and no resulting severance damage, as the fabric surfaces were not breached with this knife. This suggests a clear alternative to pointed tip knife blades. These findings will be of interest to investigators of knife crime offences, crime-reduction units, knife manufacturers and practitioners, who share the goal of identifying a safer alternative to conventional knife blade design.
|Number of pages||9|
|Journal||Science and Justice - Journal of the Forensic Science Society|
|Early online date||15 Aug 2020|
|Publication status||Published - 1 Nov 2020|


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It'll probably be sometime in 2011. I looked online when they started their Projeckt Revolution in 2008, according to Wiki they started in America in July. I'm not 100% sure that they will tour at the same time, but they might tour again sometime in the summer of 2011. Just a geuss, i could be wrong. I'm just going on when they started their tour in 2008.
1. In the end2. Numb3.What Ive Done4.New divide5.iridicent6. one step closer7. faint8. in pieces9. waiting for the end10. bleed it out11. The catalyst12. lying from you13. papercut14. crawling15.…Continue
I would like everyone to post their top 15 LP songs ( I know it's hard, but try hard (: ) so I can see how you think and make a list of LP top 15 by fans. I will mix your top 15 lists and make a…Continue

domain: hobby


February 27, 2023 — The University of the Philippines Manila College of Public Health (CPH) conducted an Operational Planning Workshop on November 21-22 2022 to review the proposed plan for the establishment of the Dr. Stephen Zuellig Program for Health Leadership and Governance (DSZPHLG) and the Program for Health Equity (PHE).
The establishment of the two programs is part of the generous donation of the Zuellig Family to the CPH.
The workshop's objectives were: (1) to explore how the two programs can contribute to the attainment of the CPH vision and mission as an institution of higher learning and as the SEAMEO TROPMED Regional Center for Public Health, Hospital Administration, Environmental, and Occupation Health; (2) to harmonize the activities of the two programs in order to support the achievement of each program’s objectives; (3) to explore strategies on how to institutionalize the two programs in the university (e.g., as part of academic offering; scaling up the programs into centers; and (4) to identify potential facilitators and barriers in the implementation of the operational plan.
The Operational Planning Workshop was designed as a two-day event consisting of group workshop activities and presentations. The highlights included revisiting the UPM-CPH vision and mission, exploring and understanding DSZPHLG and PHE and group activities that focused on identifying benefits, capacity building activities, policy directions, sustainability, possible risks, barriers, and action plans in the implementation of the two programs in the next three years.
The workshop was attended by various health leaders and key personalities from the Department of Health, Zuellig Family Foundation, Universal Health Care Study Group, and CPH. Dean Fernando B. Garcia, Jr. who led the CPH administrators and faculty members and staff, read the welcome remarks of UPM Chancellor Carmencita D. Padilla.
Dr. Ernesto O. Domingo, national scientist, university professor emeritus, and co-convenor of the UPM UHC Study Group, and Prof. Ernesto D. Garilao, former secretary of the Department of Agrarian Reform and president of Zuellig Family Foundation, gave messages.
Dr. Ernesto R. Gregorio, Jr. Dr. TJ Robinson T. Moncatar & Dean Fernando B. Garcia, Jr.
Published in UP Manila Healthscape No. 48 (February 2023)


text:
Last week I posted about the massive tax breaks enjoyed by hedge funds managers, among others. This morning David Weidner puts more numbers around this outrageous tax subsidy for some of the richest people on earth:
For example, the top 25 highest-paid fund managers made an average of $570 million in 2006. They received a $79.8 million benefit under the current tax law, mostly because they were able to declare a large percentage of income at the capital-gains rate.
The US Senate is close to raising the tax rates on these earnings from 15% (where they currently shelter under the guise of being “investments,” not what they really are–trading income) to 32.7%. (Heaven forbid that the tax rate should be 35%, which is what the rest of us would actually pay at those income levels!)
Defending their position under the farcical argument that they are entrepreneurs who deserve this social subsidy, the hedge fund industry will no doubt poor millions of dollars into preventing this change from becoming law, so don’t count on economic rationality or fairness returning any time soon.

domain: economics


text:
By Matthew Roscoe • 17 December 2020 • 18:39
CREDIT: Mszczuj/ Flickr
THREE Spanish soldiers have been punished after a video leak surfaced from a fascist party at a military base in Paracuellos del Jarama, Madrid.
The party was held on December 8, 2019, where the military men can be seen dancing with several others to the rhythm of a Blue Division song and making a fascist salute, which can be seen in a video broadcast this Wednesday, December 16, by the website La Marea.
Sources from the Spanish Army said that those punished were a non-commissioned officer, responsible for organising the party, and two soldiers who behaved “inappropriately” and who could be identified in the video.
The three were punished for a minor disciplinary offence after the video shows a group of people, in uniform and in civilian clothes, dancing to a rock version of the song Primavera (the anthem of the Blue Division, which fought against the Soviet Union during the Second World War under the Nazi regime), some of them holding beers and waving.
The video, which the army learned about in January when the disciplinary proceedings were opened, was broadcast in the midst of the controversy over the leaking of a chat room of retired soldiers in which there was talk of “shooting 26 million Spaniards” and over the sending of letters to the king by former army commanders charging the “social-communist government”.
This news has apparently set off the alarms within the Spanish military that the extreme right may have infiltrated the Armed Forces.
Thank you for taking the time to read this news article “Spanish soldiers punished after leak of fascist party video”. For more UK daily news, Spanish daily news and Global news stories, visit the Euro Weekly News home page.
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With eight seasons under its belt, “CSI: NY” is shaking things up in Season 9 with special episodes in November sweeps that take us home with team members on their days off, and in an episode, airing Friday night, featuring music from Green Day to narrate the dialogue-free action sequences.
Posts Tagged Eddie Cahill
When “CSI: NY” returns with all-new episodes on Friday, January 6, the series will pack a powerful emotional punch as it goes behind the scenes of the Mixed Martial Arts world to investigate the death of a fighter, whose body has been charred beyond recognition.
‘CSI: NY‘ had to rethink its plan for Season 7 when Melina Kanakaredes opted to vacate the role of Stella, setting the stage for Sela Ward (‘Sisters’) to join the… More
Wanna know what’s coming up on your favorite show? Tuesday is tease-day at Fancast, and MattMtvguy@gmail.com is the place to send you questions. Here now the scoop! Did you enjoy… More


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The 2018-19 Common Book is "White Tiger"
Winona State University Common Book Project will feature "White Tiger" by Aravind Adiga as its 2018-19 common book.
About the Book
"White Tiger" tells the story of Balram Halwai and his unlikely journey from the Indian village of his birth to employment as driver and servant to a wealthy family in Bangalore. Narrated through a series of letters to the Chinese Premier, the novel offers a darkly comical, scathing portrayal of poverty and corruption of modern Indian society. More broadly, the novel explores questions of globalization, social and economic justice, democracy, and the legacy of colonization. "White Tiger" is at once an arresting story of individual ambition and a provocative inquiry into some of the most urgent questions faced by contemporary society.
Published in 2008, "White Tiger" was Adiga’s debut novel and the winner of the Man Booker Prize for Fiction. Adiga was born in Madras (now Chennai), India, and grew up in Mangalore; he was educated at Columbia and Oxford universities. His most recent novel, "Selection Day" (2017), tells the story of two brothers in Mumbai who are raised by their ambitious father to become cricket stars; it was an NPR Best Book of the Year. Before becoming a novelist, Adiga worked as a financial journalist, publishing articles in the "New Yorker," "Financial Times," "Times of India" and "Time." He lives in Bangalore.
If you choose to read "White Tiger," incorporate what you take away from the book into your life while at the university. The book will be adopted in numerous sections of ENG 111, College Reading and Writing, and may be adopted in other courses as well. Use this opportunity to learn more about the greater community and turn your knowledge into action.
Where to Buy
"White Tiger" is published by Free Press, an imprint of Simon & Schuster, and will be available from the WSU Bookstore and other booksellers. Additionally, a packet of teaching and contextual materials for prospective adopters will be available by midsummer. Faculty adopters should simply list the book (ISBN 978-1416562603) on their book request form through the WSU Bookstore.
Funding for the Common Book Project has generously been made available by the College of Liberal Arts and the WSU Bookstore. For more information about the project, please contact Prof. Ann-Marie Dunbar at ADunbar@winona.edu.

domain: artistic


text:
Disease-modifying properties of CGRP pathway mAbs: a debated matter
Data from clinical trials have demonstrated that calcitonin-gene related peptide (CGRP) pathway monoclonal antibodies (mAbs) are equally as effective and more tolerable than other classes of preventive migraine treatments.1 However, one question about this new class of treatments remains: can CGRP pathway mAbs be classified as disease-modifying treatments (DMTs)? As part of the scientific session on CGRP pathway mAbs at the International Headache Congress (IHC) 2021—being held as a joint congress of the International Headache Society (IHS) and the European Headache Federation (EHF)—Prof. Lars Edvinsson (Lund University, Lund, Sweden) and Prof. Elizabeth Leroux (Brunswick Medical Center, Montreal, Canada) debated whether CGRP pathway mAbs have disease-modifying properties. Prof. Edvinsson provided the “pro” argument supporting the disease-modifying effects of CGRP pathway mAbs, opposed by Prof. Leroux’s “con” argument.
Why CGRP pathway mAbs should be classified as DMTs
Prof. Edvinsson started by stating that CGRP pathway mAbs represent a revolution in the scenario of preventive migraine treatment. He then presented data on efficacy and a favorable safety profile that, in his opinion, supported the classification of CGRP pathway CGRP mAbs as DMTs. First, Prof. Edvinsson highlighted that CGRP pathway mAbs are specifically designed according to migraine pathophysiology and show high specificity for their target.2 Next, he presented data demonstrating the efficacy of CGRP pathway mAbs in reducing intensity and frequency of migraine attacks, thus decreasing the burden of disease on patients’ life.3-6 Additionally, Prof. Edvinsson argued that the use of CGRP pathway mAbs might also reduce the risk of medication overuse by decreasing the consumption of acute treatments.6
According to Prof. Edvinsson, the disease-modifying properties of CGRP pathway mAbs would also be supported by their efficacy in reverting chronic migraine (CM) to episodic migraine (EM), with this effect having been shown to persist for over a year.7 Prof. Edvinsson ended by pointing out that CGRP pathway mAbs are characterized by a good tolerability profile—similar to placebo—with the severity of most adverse events (AEs) being mild to moderate.4
Why CGRP pathway mAbs should not be classified as DMTs
Prof. Leroux started her argument by clarifying that, in her opinion, the questionable point is not whether CGRP pathway mAbs are effective or not, but whether they can be defined as DMTs. She explained that all DMTs should meet two main criteria: 1) alter the expected course of the disease beyond symptom control and 2) slow or revert the pathophysiological processes leading to disease progression. In Prof. Leroux’s opinion, the first reason why CGRP pathway mAbs are not DMTs is that migraine is not a progressive or degenerative disease.8 Indeed, the rate of progression of the disease over time is generally low,9 and the likelihood of remission is greater than that of progression.10 Additionally, she noted that migraine remission is possible even without the help of any treatments. In fact, as Prof. Leroux explained, certain changes in patients’ behavior might act as “disease-modifiers” and decrease the frequency and intensity of migraine attacks.11
Prof. Leroux also presented data showing that after discontinuation of CGRP pathway mAbs, the beneficial effects of the treatments only persisted for a limited time.12 In her opinion, these results suggest that CGRP pathway mAbs do not exert a long-term disease-modifying effect on migraine pathophysiology. Moreover, Prof. Leroux remarked that the current lack of reliable biomarkers precludes identification of any possible changes exerted by CGRP pathway mAbs on migraine pathophysiology.13
Prof. Leroux concluded that, in future, the definition of precise treatment goals and the identification of biomarkers for migraine progression might help to better assess the disease-modifying properties of CGRP pathway mAbs. However, in her opinion, defining these treatments as DMTs is currently “excessive and premature”.
There is no doubt that CGRP pathway mAbs are a scientific breakthrough in the field [of migraine care].
Drellia K, Kokoti L, Deligianni CI, Papadopoulos D, Mitsikostas DD. Anti-CGRP monoclonal antibodies for migraine prevention: A systematic review and likelihood to help or harm analysis. Cephalalgia 2021;41:851-64.
Edvinsson L, Haanes KA, Warfvinge K, Krause DN. CGRP as the target of new migraine therapies - successful translation from bench to clinic. Nat Rev Neurol 2018;14:338-50.
Huang IH, Wu PC, Lin EY, Chen CY, Kang YN. Effects of Anti-Calcitonin Gene-Related Peptide for Migraines: A Systematic Review with Meta-Analysis of Randomized Clinical Trials. Int J Mol Sci 2019;20.
Xu D, Chen D, Zhu LN, et al. Safety and tolerability of calcitonin-gene-related peptide binding monoclonal antibodies for the prevention of episodic migraine - a meta-analysis of randomized controlled trials. Cephalalgia 2019;39:1164-79.
Han L, Liu Y, Xiong H, Hong P. CGRP monoclonal antibody for preventive treatment of chronic migraine: An update of meta-analysis. Brain Behav 2019;9:e01215.
Zhu Y, Liu Y, Zhao J, Han Q, Liu L, Shen X. The efficacy and safety of calcitonin gene-related peptide monoclonal antibody for episodic migraine: a meta-analysis. Neurol Sci 2018;39:2097-106.
Lipton RB, Tepper SJ, Silberstein SD, et al. Reversion from chronic migraine to episodic migraine following treatment with erenumab: Results of a post-hoc analysis of a randomized, 12-week, double-blind study and a 52-week, open-label extension. Cephalalgia 2021;41:6-16.
Global, regional, and national burden of migraine and tension-type headache, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol 2018;17:954-76.
Buse DC, Greisman JD, Baigi K, Lipton RB. Migraine Progression: A Systematic Review. Headache 2019;59:306-38.
May A, Schulte LH. Chronic migraine: risk factors, mechanisms and treatment. Nat Rev Neurol 2016;12:455-64.
Schwedt TJ. Preventive Therapy of Migraine. Continuum (Minneap Minn) 2018;24:1052-65.
Kuruppu DK, North JM, Kovacik AJ, Dong Y, Pearlman EM, Hutchinson SL. Onset, Maintenance, and Cessation of Effect of Galcanezumab for Prevention of Migraine: A Narrative Review of Three Randomized Placebo-Controlled Trials. Adv Ther 2021;38:1614-26.
Durham P, Papapetropoulos S. Biomarkers associated with migraine and their potential role in migraine management. Headache 2013;53:1262-77.

domain: literature


DRT Billet Aluminum Barrel Adjustable Sway Bar Link Kit | Polaris RZR Turbo S
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The kit also includes adjustable links that allow you to fine-tune your sway bar assembly for improved performance. The adjustable links are made from high-strength billet aluminum for maximum durability and strength.
The DRT Motorsports Billet Aluminum Adjustable Barrel Sway Bar Link Kit (M12) is an excellent choice for those looking to upgrade their suspension system in style and performance. With its heavy-duty construction and adjustable links, it is sure to improve the handling of your vehicle while providing a stylish look.


text:
What a neat and historic building that is a must see when down around the Mallory Square Docks. This Community Center and restaurant provides a interesting view of cuban culture. The food is so yummy with a tropical focus which mixes so nicely with Key West. Very popular is the arroz con pollo chicken and yellow rice. Each day they have salsa bands playing in the outside bar patio area. Most of the Florida Keys restaurants have Cuban Food influences.
For sure get the Cuban Nachos to start and then the menu is wide open with goodies for the main course. A good drink choice to try some thing different is the banana bash. The banana bash recipe uses cruzan banana rum and creme de banana, then served frozen smoothie style. Frozen smoothie style drinks go so good with the spicy foods. Chicken wing lovers can get a nice alitas de pollo plate. Cuban style chicken wings are marinated for a great taste. Very good is the cubano classic sandwich, which is always hot pressed panini style with roast pork, baked ham, swiss cheese, mustard and thin sliced pickle.

domain: food


text:
First Lady Michelle Obama today brought a room filled with Chicago business and community leaders to tears as she challenged them to commit to the most important unfinished work of our lifetime — widening the circle of opportunity for every last one of our children.
Mrs. Obama was in Chicago to address the Public Safety Action Committee, a new private-sector effort launched by Mayor Rahm Emanuel to address the violent crime that is taking a terrible toll on the youth of the great city she and I both call home.
As the First Lady pointed out, thousands of Chicago children are now living in neighborhoods where a funeral for a teenager is considered unfortunate, but not unusual; where wandering onto the wrong block or even just standing on your own front porch can mean putting yourself at risk.
This needs to change. In Chicago and across the country, we need to create ladders of opportunity for our young people. We need to give our children mentors who push them and nurture them. We need to teach them the life-skills they need to succeed.
We need to give them alternatives to gangs and drugs – safe places where they can learn something and stay out of trouble. Every single child — in cities like Chicago and all across America — has boundless promise, no matter where he or she lives.
And as Mrs. Obama told the leaders in the room yesterday, giving our kids the chance to fulfill that promise and grow into productive adults who lead meaningful lives – that’s on us. “That’s our job,” she said.
You all are here today because you know that this is about more than just fulfilling a business obligation or a civic obligation…you know that this is a moral obligation. Because ultimately, this city and this community will be judged not just by the beauty of our parks and lakefront, or the vitality of our businesses, but by our commitment to our next generation.
I think my husband put it best when he spoke to the people of Newtown, Connecticut back in December, and he said – and this is his quote: “This is our first task, caring for our children. It’s our first job.
If we don’t get that right, we don’t get anything right. That’s how, as a society, we will be judged.
And by that measure, can we truly say, as a nation, that we’re meeting our obligations?
Click to the next page to watch her tearful plea!
First Lady Michelle Obama Makes Tearful Plea [WATCH] was originally published on elev8.com
Pastor Paula White Breaks Silence On Divorce, Stroke And Her Alleged Affair
What Does It Mean To Be "Equally Yoked?”
Bishop Carlton Pearson Says "God Is Not A Christian..."
Bebe Winan's ex wife Debra speaks..You decide for yourself.
Why do Members of a Baptist Church put their finger up when walking in church? Where did this orginate?
10 Exemplary Black Celebrity Fathers
Healing Scriptures: Bible Verses for Living in Divine Health
Key Lime Cake III

domain: sociology


Assuming both consoles are open on the bottom and the hose routing will remain the same:
Remove steering wheel.
Unscrew/bolt the helm mounting plate/bracket.
Drop helm down from console to deck.
Remove and replace console, reverse process to reinstall helm.
Caveat: that would work on mine. Suppose it depends on your exact setup.
If you do have to pull hoses, you'll need to bleed the system - not a big deal, but a bit of a pain and potentially messy.


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Edgy Demi is my ultimate inspiration!!..fashion wise, music wise, and just her overall is an inspiration!
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Girrlscout: I don't say this enough but thanks for following me, it means a lot. #followerappreciation
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@Shawnyne Garren Lives I'm gonna need you to do this for me!!!
Hoop Earcuff. <3 I actually could not love this more.


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UK – Nestlé UK and Ireland has announced that from October 2020, it will move to the Rainforest Alliance certification for cocoa sourced for the KitKat brand, marking the end of the company’s partnership with the Fairtrade Foundation.
The food and confectionery company said that migrating to the Rainforest Alliance certification will harmonise its cocoa sourcing accreditation as part of the world’s largest food and beverage company global commitment to sustainably source all its cocoa through the Nestlé Cocoa Plan by 2025.
As part of the new agreement, Nestlé said that it will provide financial assistance to cocoa farmers, in addition to investing US$1.25 million in an industry-first living income pilot and a further US$624,000 in community projects, as the partnership with Fairtrade Foundation ends.
Through its expanded Cocoa Plan programme and partnership with the Rainforest Alliance, the company added that it will continue working to improve livelihoods and productivity in cocoa-growing communities.
While the new partnership has drawn criticism particularly at a vulnerable time for the 16,000 small cocoa farmers in Ivory Coast that KitKat buys its cocoa from, Nestlé noted that it will provide financial support to enable Fairtrade farmers to certify their farms to the Rainforest Alliance Sustainable Agriculture Standard, if they wish.
The company also said that it will be maintaining the same level of cocoa spend for the 2020-21 season and investing in a series of initiatives to support farmers and cocoa growing communities over the next two years.
“We are aware that the move will have an impact on some farmers, and we are working hard to mitigate this,” said Simon Billington, Global Technical Manager for Nestlé Confectionery.
“We want to continue working with our Fairtrade farmers and we will pay for them to get to the level required by the UTZ standard, which since 2018 has been part of the Rainforest Alliance certification programme. If farmers are not able to do this in time for the next crop, we will also provide them with financial support for the coming year,” Billington explained.
Nestlé expects to buy 7,000 metric tons of cocoa in the 2019-20 season that ends September 30, and plans to spend the same for the following season, reports MarketWatch. For the 2020-21 cocoa season, Nestlé said it expects to pay US$420,000 for the Rainforest Alliance premium, and that it will spend about US$490,000 to help farmers transition to the certification.
“Our successful partnership with Fairtrade is ending as we harmonise our certification for sustainable sourcing internationally,” Billington commented.
“The Rainforest Alliance has significant experience working with cocoa farmers in understanding and implementing robust sustainability criteria that drives positive change, and we look forward to deepening our collaboration in the coming years.”
The move comes as the business is striving to invest more in sustainably sourced cocoa and harmonises certification for confectionery products within its global portfolio.
Over the past decade, Nestlé said that it has invested over US$224 million in the Nestlé Cocoa Plan, which currently delivers 200,000 tonnes of certified sustainable cocoa annually.
Through the plan, the Swiss food and beverage giant noted that it has expanded its efforts to include providing more disease-resistant trees to cocoa communities, working to reduce child labour and has trained 114,000 farmers on sustainable farming best practice since 2018.
The company plans to ensure that 100% of the cocoa it uses for confectionery worldwide is sourced from the Nestlé Cocoa Plan by 2025.
Nestlé noted that its UK and Ireland business has sourced 100% certified, sustainable cocoa for its entire chocolate and biscuit portfolio since 2015, and this latest step will ensure consistency and security across the business’s global supply chain.
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The city’s cultural ambitions are growing in the run-up to the 400th anniversary of the Mayflower voyage
Once, they provided the stones that built Paris. Now, the disused quarries of Saint-Maximin are being transformed into venues for art
Several of the city’s avant-garde spaces are suburban. Now it looks like a major central gallery will move out, too
On the southern coast of France, a new exhibition is exploring our troubled relationship with the world’s oceans
In Paris the art world and the book world frequently overlap. Here are some of the most interesting initiatives across the capital
The artist’s exhibition at the Centre Culturel Irlandais in Paris explores big themes of climate change, landscape and loss
Are there too many languages and can translation ever really bridge our gaps in understanding?
Both government and business need to realise how much the art scene here is worth celebrating, and sooner rather than later
The city is known for its heritage, but its contemporary cultural scene is struggling
Is the redevelopment of Finland’s open spaces changing how local artists work?
Jussi Kivi represented the country at the Venice Biennale in 2009, before retreating from the limelight. Now he’s back with a book from Helsinki’s edgelands
The Serlachius Museums in Mänttä are an admirable example of how art can flourish outside Helsinki
A recent court case involving Wikimedia in Sweden has taken the art world by surprise
Artists and museums in the Russian capital testify to the uneasy relationship between art and the state
The grey-green of oxidised bronze is common on public buildings throughout northern Europe
The Finnish arts organisation Checkpoint Helsinki has had its funding cut. Can it survive?
The Lorck Schive art prize has an important role to play in Trondheim’s growing art community
Can artists and the wider art world use social media for more than self-promotion? Some certainly think so…
Art, made of coffee, shown in a bookshop: Ian Bourgeot’s work at Helsinki’s Arkadia breaks conventions in more ways than one
Engagement, interaction, the co-creation of meaning: these are the museum buzzwords of today. But what do they actually mean?
‘Contemporary art is a very elitist sphere,’ admitted Frame’s head of programmes Taru Elfving, ‘and it could be so much more’
‘The days of museums hoarding information are over.’
Artists explore how society is shaped by the natural environment in the Baltic region
Moreau Kusunoki’s designs look nice, but the public shouldn’t have to pay


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- Former Marine steps down as July 4 parade grand marshal of Texas town after threats of violence
- Houston’s first medical marijuana dispensary is now open in the Heights. So how do you qualify?
- Generations of Houstonians grew up eating at the city's oldest Tex-Mex restaurant
- Texas man catches massive alligator snapping turtle, then releases it back into the wild
- Astros send Jose Siri to Class AAA Sugar Land, activate Jake Meyers
- Rockets' NBA draft picks: How the experts think Houston did
- Clarence Thomas wants Supreme Court to revisit Texas sodomy law


As the GOP and Democratic presidential candidates vie to grab the primary prize in Maryland next week, many eyes are on another race.
Soon, Baltimore will need a new mayor and activist DeRay McKesson wants the job of picking up the pieces of a fractured city that has been on fire since the death of Freddie Gray. The Baltimore native, who announced his campaign early February, insists he is not a politician. Instead, the black lives matter protester who pushed for change from the outside, is now aiming to be in position to push from the inside.
Above: McKesson speaks with voter Karen Olson as he canvasses in Charles Village in Baltimore, on March 26, 2016.


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THE European Union (EU) hopes that its free-trade deal with Singapore will enter into force this year, said its top trade official on Friday.
This signals the EU's desire to press on with open trade, said Trade Commissioner Cecilia Malmstrom, a day after US President...


The first sign that this wasn’t going to be a typical corporate earnings season came early on the morning of July 12, when PepsiCo Inc. unveiled an odd set of results. Growth in unit sales, it said, was essentially zero in North America. Revenue rose, though, driven by the double-digit price increases Pepsi slapped on its snacks.
Then, one after another, major consumer companies came out with earnings that mimicked the Pepsi numbers: Clorox, Conagra Brands, and Kraft Heinz. The details were different in each case—some reported sharp volume declines, and others came in unchanged—but the broad trend was crystal clear: Output growth is dead, prices have been jacked up, and revenue is, as a result, rising moderately.


Generators are essential because they act as backups for your business’ power sources. They convert different fuels, including diesel, gasoline, or propane, into usable electricity. The type of generator that will be efficient for your business is the industrial generator.
The primary purpose of these generators is to assure business owners of a continuous power supply in their grid systems despite any power failure. They are different from residential generators in that they can withstand excessive usage over a long time under challenging conditions.
Different manufacturers offer a wide range of quality industrial generators to choose from. You should choose one specifically suited for your type of business for maximum performance.
- Diesel generators
Diesel-run engines are known for their long life, lower maintenance, and durability. One operating at 1800 rpm can run for approximately 12000-30000 hours in between maintenance. A similar gasoline engine may need to be serviced after 6000-10000 hours.
The industrial diesel generator is as efficient because diesel burns at a cooler rate than gasoline. This reduces the heat and wear in the engine. This engine’s power production may also incur lower costs due to diesel’s high efficiency and energy density.
Diesel industrial generators’ technology has been improved to ensure that they produce minimum diesel emissions. Blends containing upward of 20% biodiesel can be safely used in diesel engines.
- Petroleum generators
These industrial generators are usually cheaper than most industrial generators. As much as gasoline generators can run for a long time, they need to be maintained more extensively. The gasoline may deteriorate the engine’s rubber components, causing it to wear faster.
The generator’s gas storage is also at a higher risk of explosions and fire. Additionally, gasoline also deteriorates with time, making long-term storage less ideal. Petroleum industrial generators require more care but are effective all the same.
- Natural gas generators
These industrial generators use liquefied petroleum gas or propane. When using them, you can store the fuel above or below ground. Natural gas also burns clean, therefore reducing emission issues. Although natural gas industrial generators may initially be expensive, they are very durable.
However, transportation may be expensive as it must be trucked to your business location. This generator is ideal for you if you need a lower output for a smaller business. If you desire more output, consider getting a bigger one.
These generators are a perfect backup if you run a technology provisions business.
- Portable industrial generators
Portable industrial generators cannot be ferried by hand but can be mounted on trailers. Massive portable generators are excellent if you run a construction business. That is because you can use it on various sites before they have any established power supply.
They are also ideal for emergency responses, where a large amount of electricity output is needed on-site.
- Marine generators
Marine generators are designed to withstand the rugged marine environment. There are specific companies that manufacture industrial generators that are specific to marine conditions. These generators are typically used near salty water and are suitable for oil rigs or large sea vessels.
While you can get marine generators with either gas or diesel, industrial ones utilize diesel exclusively.
- Heavy-fuel oil generators
Heavy-fuel oil generators save you high costs, even more than diesel. They are generally smaller, mainly because they use a smaller higher-speed engine. When you want to purchase this generator, you need to consider the fuel availability; because it is listed under category 5 or 6.
Why you need an industrial generator
An industrial generator will be a valuable investment for your business. It will save you from losses you might incur due to power outages. Here are five reasons why your business needs an industrial generator.
- Your business will be seamless
The first benefit of having an industrial generator is your business will run smoothly whether there is a primary power supply or not. From healthcare to retail, seamless operations will provide a sense of calm and stability for your business.
An industrial generator ensures ‘it’s business as usual’ thanks to minimal power interruptions. You can comfortably use your laptop to play online casino slots real money games as your manufacturing plants run seamlessly.
- Your workforce is assured of their shifts.
As a business owner, you already know how important your employees are for the success of your business. So, taking care of them should also be a priority. When the power is on, your employees will not have to lose shifts that help them support their families.
Additionally, regular shifts will produce adequate output to meet your clients’ needs.
- Keeps your inventory from being damaged
Depending on the nature of your business, you may have products that rely on heat or refrigeration to remain viable. Therefore with a temperature-sensitive inventory comes the pressure to ensure that power is up and running.
A backup industrial generator will save you from the financial losses and frustration of long-lasting electricity outages. Moreover, keeping the power going can help save many lives if you are in healthcare.
- You will have peace
Your business can be a source of frustration and stress when things are not going well. One such thing is a power outage. When you have an industrial generator, you will have peace as you will not constantly be worrying about any unexpected outage.
Whenever there are emergencies like storms, your generator will cover any event of electricity outages.
Investing in a generator will help improve your sales. With the above information, you can make an informed purchase.


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I’ve always wondered what it must have been like for those ancient Romans as their world began to collapse around them. Here they were, the only superpower, a first class military, abundant wealth and status and yet, just outside their walls stood a rag-tag army of immigrants. Yes, these barbarians, this tribe of Goths, were immigrants. They came across the boundaries of the Empire, they were part of a great migration that would eventually swallow up the once powerful Roman Empire and plunge Europe into what we call today, the Dark Ages.
I’m not going to go into the history of what happened but I am curious as to what those Romans felt as they watched their way of life crumble before their eyes. What warnings did they have? What propaganda did the Emperor and Senate use to insure them that all would be just fine? It is hard for me to imagine their feelings, then again, as I watch the daily drama unfold on Twitter and the various media sites, I’m beginning to understand what may have been going through their minds. Of course, that is all assuming that they, the Romans, were aware that something big was happening, that their world was experiencing a cataclysmic shock that would be felt for generations to come. Back then, there was no Social Media sites, there was no instantaneous news feeds running 24/7, and once the roads were cutoff, even getting messages into the city would have been greatly curtailed. I can only imagine a city rife with rumors, each one more shocking that the next. Unscrupulous businessmen taking advantage of the fear, selling security in the form of freed gladiators, who would protect your home and family from the impending hoard. Of course, being human the citizens would have done anything for security, just like today, we will do anything for security even if it means giving up our precious freedoms. Only later, when it’s already too late, do we find these securities to be nothing more than phantoms, there one moment gone like a wisp of smoke the next.
We Americans are not immune from the changes we see all around us. Nations, like North Korea, Iran and others, want to have nuclear capabilities. They see the larger nations as a threat, bullies who can punish them economically and so like the little kid being bullied in school they seek to even out the playing field, and that means having “the bomb.” The big kids cry foul, claim that they’re not playing by the rules but then again, neither did those Germanic tribes who sacked Rome play by the rules. So, what do we do? I have no answer for the greater questions, in fact no one does. There are no easy answers, no one size fits all solutions that will make everyone happy. After all we are dealing with human beings, a species that for centuries has never been able to see the consequences of their actions.
Then the question becomes, are we doomed? No, at least I hope not. Sure there are those days when it looks pretty dismal then we have those moments of light. People reaching out to help one another, some even crossing boundaries that once were impassable to pull each other along. The recent hurricanes in Texas and Florida have shown our better nature as people reached out across, social, racial and cultural divides to help one another. Heroic efforts of first responders and ordinary citizens, risking life and limb to help, again shows that deep connection we have. Somewhere, in each of us there is that spark of the Divine that despite our best efforts to keep it hidden from view refuses to be closeted.
Yesterday was the 16th anniversary of the terrorist attacks on September 11. I looked up into a bright blue September sky, as a plane flew overhead preparing to land at Logan. That plane is not a villain, it is not inherently evil, it is just a machine designed to carry people across great distances in a matter of hours and not days. It is one of humanity’s crowning achievements, the very idea of flight, of escaping the bonds of earth and flying into the heavens. Yet, on that day 16 years ago, this marvel of engineering was turned into a weapon of mass destruction. Yes, humanity is capable of doing great things, wonderful things and, humanity is also capable of so much destruction.
In Matthews Gospel Jesus is quoted as saying, “fear him who can destroy both soul and body in hell,” I have to wonder, as I read the latest social media postings and watch the news, if the one we need to fear is not the other but the one in the mirror.

domain: politics


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There may be situations where you suspect that some of the foods you store in the refrigerator have deteriorated to the point where it may adversely affect your health. It is important to know the shelf life of each food in the refrigerator. These are important because if these steps are not done correctly, the growth of bacteria in food can accelerate. Other factors that influence the waiting time of food in the refrigerator are:
Cooking techniques are also important for the shelf life of the food in the refrigerator. For example, frying and cooking do not stay healthy at the same time. The time between cooking and cooling is also important.
In general, it is not good to reheat food more than once. Leftover food should not be reheated more than once. Doing this several times will cause the bacteria to multiply, as the ideal temperature for growth is between 5-65ºC. Overheating also reduces the quality and nutritional value of food.
The advice of experts is to subtract the amount consumed at that moment so that you do not have to reheat the food in the refrigerator. Before eating, it should be heated to a temperature of about 75 ºC, without boiling, but just enough to eliminate microorganisms.
The only way to be sure food is in good condition is to know exactly what the expiration date is, when you open a can or prepare a recipe and how many days it will keep.
Not all food is kept in the refrigerator. Many foods have natural protection that prevents the growth of pathogens that cause them to spoil. Highly acidic foods such as pickles or pickled foods, foods with a low water content, foods with a high salt content, and foods protected with a skin, such as many fruits and vegetables, have natural protection.
There are also foods such as milk, which, while usually perishable, are pasteurized and can be kept much longer unless the packaging they come in is opened.
In addition, there are foods that should be kept in the refrigerator. Foods that need to be kept cool are generally raw meat, processed meat products, raw fish, smoked and marinated fish, milk-based sauces and creams, soft cheeses, yogurt and fermented dairy products, dairy desserts, butter, eggs, cooked foods, raw and cooked Meals prepared with a mixture of foods, peeled, sliced or cooked fruits and vegetables and prepared foods.
The shelf life of various foodstuffs in the refrigerator until consumption is as follows:
Vegetable puree or vegetable soup: 3-4 days
Lentil soup: 3-4 days
Roast chicken: 2 days
Grilled red meat: 1 day
Grilled fish: 1 day
Boiled egg: keeps for up to 7 days in its own shell
Natural tomato sauce, cooked or raw: 3 days
Homemade sauces: 1 day


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One of the things that I hope to accomplish in writing about my experience as both a gay man and as an ex-Christian is to give hope and courage to those who are struggling with their sexuality or over their doubts about their faith. Regarding faith, there’s definitely a place for doubt and for questioning, but there comes a point where you have to ask yourself if there’s genuine belief within you or if your doubts are your intellect trying desperately to tell you something about yourself.
Regarding sexuality, there is no such thing as questioning. There may be confusion within a person over the kinds of sexual desire he or she is experiencing, whether those feelings be heterosexual, homosexual, or bisexual; or an even more frightening reality of an individual coming to the realize that he or she is transsexual—that is, that he or she was born one sex but knows at his or her core, in the same way that you and I know that we are the sex we are, that he or she is the opposite. From conversations with transsexual friends, I know now how incredibly difficult and lonely a road this can be—but it shouldn’t be.
Yet still, there should be no questioning, or at least there shouldn’t be a culture that forces an individual to question what they know in their heart to be true.
This is especially true of conservative, anti-gay blogger Jonathan Merrit, who was came out recently as gay but has unfortunately taken the sad route of self-loathing Christian gays who make their mea culpas and then go into “therapy” (i.e., “reparative”, ex-gay therapy). They come out as a way of encouraging other closeted gays to do the same—to throw themselves on the “unconditional love” of their hateful communities and to seek “help” from monstrous so-called therapists who promise to be able to “fix” them (i.e., make them “normal”, i.e., heterosexual).
What Jonathan Merrit needs is help to accept himself as a beautiful human being who happened to be born homosexual. Although I never sought therapy (thankfully), having been there myself as a once-Christian gay man I know how terrifying and lonely it is to come out of the closet, especially when your entire community is made up almost exclusively of conservative Christians who believe that homosexuality is a sin and an abomination.
There is no brokenness about homosexuality. If there was, fundamentalists wouldn’t be fighting so hard against it and lying so much about it. If there was, all homosexuals would be leading disastrous lives and dying at age 42 (or whatever age they’ve worked out we die at). If there was, the president of Exodus International wouldn’t say that he’s never met a gay person who’s successfully changed their orientation, and Robert Spitzer wouldn’t have renounced his research finding that ex-gay therapy worked.
Regardless of whether you belief in God (or god(s)) or not, it’s such a waste of an already short existence on this wonderful planet to strait-jacket yourself into a life of loneliness and misery in order to satisfy the demands of a community that refuses to acknowledge any perspectives other than their bigoted, narrow, judgmental and puritanical one.
So my call to action for today is for anyone who reads this and agrees with the sentiment to write to Jonathan Merrit and plead with him to not go down the road of self-loathing and unhappiness and to embrace and love himself and the way that he was born. Plead with him to accept the potential happiness that’s there if he’ll just venture outside and look for it. I did, and my only regret is not having met my wonderful boyfriend Jay sooner.
I saw the article this morning on The Advocate about your coming out as gay, and have to say that while I admire the courage it took to admit that publicly, even under pressure to do so, I’ve been where you are. I was born into a Christian family and was raised in the fundamentalist tradition, but came out as gay in 2008 at age 26 after over a decade of struggling with feelings that conflicted with the teaching of my faith. I did so after an extensive amount of research into the clinical and scientific origins of homosexuality, as well as researching the truth about what history and the Bible truly says about it. What I found is that there is nothing in the Bible to suggest that it condemns committed relationships between same-sex couples, and that there is no evidence in the scientific community to indicate homosexuality is anything but natural. What’s unnatural and harmful is attempting to alter your sexual orientation when there’s nothing wrong with the one you have.
It’s impossible to express to you the regrets I have over all of the wasted years that came with fighting with my innate nature and with not coming out sooner. But there was also an indescribable relief at finally embracing who I am. I had to ask myself whether it was more natural to try to fight what had come without bidding (I had no exposure to the “gay lifestyle” growing up) or to accept the evidence within myself. I have no regrets about that decision today. It took some time and looking, but I’m with the man I plan on spending my life with, and here’s nothing different about our love from that of my parents or any of my heterosexual friends who are married.
What I want to say by all of that is don’t throw away the chance to find that for yourself by throwing in your lot with the ex-gay community. Your “indiscretion” showed where your heart truly lies, and what it truly desires, and that’s not wrong. I know from experience that it may seem like giving up to “give in” to what the Church calls temptation, but it’s not giving up to truly embrace who you are. Listen to your heart.
David Philip Norris


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Region's best food showcased
TWELVE of the region’s best gourmet and boutique food businesses were represented under the ‘Northern Rivers Food’ banner at the Sydney Good Food and Wine Show at Darling Harbour Exhibition Centre 10 days ago.
“The Sydney Good food and Wine Show is Australia’s largest consumer food, drink and cookware exhibition, attracting over 40,000 consumers and buyers,” Northern Rivers Food Coordinator Lois Kelly said.
“This gives our gourmet producers an outstanding opportunity to promote their produce to consumers, to professional buyers, and to the food media.
“Following on from the success of last year’s show, Northern Rivers Food was able to secure the best position in the show which enabled member product to really stand out and shine.
“It’s a stunning marketing opportunity,” Northern Rivers chair and Brookfarm co-owner Pam Brook said.
“We were in a high impact area right near the front door, and our logo and colours really stood out. We had thousands of people milling around our stand, attracted by our professional set up and great range of products.”
Ms Kelly and Ms Brook said, over the three days of the show, Northern Rivers producers were visited by consumers, buyers and distributors.
Good contacts were made, business deals initiated, and thousands of consumers were able to sample – and be impressed by – Northern Rivers-grown foods.
Over the next few months, Northern Rivers Food would work with exhibitors to track outcomes from the event and to follow up opportunities to further promote member products.
“We have booked the same space for next year,” Ms Kelly said.


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domain: entertainment


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Onmyoji Arena has some really fabulous skins, and recently there was the “Heian-Kyo School” series. # OnmyojiArena See More AFK Arena Tier List for Mid Game (Lvl.
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Over the past year, the AMA brought together specialty societies and other health care professional organizations to partner with CMS on the first overhaul of E/M office visit codes in more than 25 years. Explore the AMA’s resources for combating administrative burden and stay informed on critical updates like E/M office visit code changes.
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James L. Madara, MD, on AMA's continuing commitment to doctors 175 years later
AMA's Moving Medicine series features physician voices and achievements. Learn more in this discussion with James Madara, MD, on AMA's continuing commitment to doctors 175 years later.
The American Medical Association's 175th Anniversary
Celebrate the American Medical Association's 175th anniversary. Learn more about when medicine meets the moment.
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Fast and complete removal of the 5-fluorouracil drug from water by electro-Fenton oxidation
- 196 Downloads
Cytostatic drugs are a troublesome class of emerging pollutants in water owing to their potential effects on DNA. Here we studied the removal of 5-fluorouracil from water using the electro-Fenton process. Galvanostatic electrolyses were performed with an undivided laboratory-scale cell equipped with a boron-doped diamond anode and a carbon felt cathode. Results show that the fastest degradation and almost complete mineralization was obtained at a Fe2+ catalyst concentration of 0.2 mM. The absolute rate constant for oxidation of 5-fluorouracil by hydroxyl radicals was 1.52 × 109 M−1 s−1. Oxalic and acetic acids were initially formed as main short-chain aliphatic by-products, then were completely degraded. After 6 h the final solution mainly contained inorganic ions (NH4 +, NO3 − and F−) and less than 10% of residual organic carbon. Hence, electro-Fenton constitutes an interesting alternative to degrade biorefractory drugs.
Keywords5-Fluorouracil Antineoplastic BDD Cytostatic Electro-Fenton Water decontamination
Pharmaceuticals are non-regulated trace organic emerging contaminants that are ubiquitous in the aquatic environment due to discharge of effluents from pharmaceutical industry, hospitals and municipal wastewater treatment facilities (Feng et al. 2015; Petrie et al. 2015). In most cases, these pollutants are also present in the digested sludge, potentially entailing a high ecotoxicological risk (Martín et al. 2012). In order to avoid the propagation and subsequent accumulation of pharmaceutically active compounds in water bodies, specific prevention systems should be devised at major point sources of pollution. In the case of pharmaceuticals, such locations are hospitals and production sites. Unfortunately, removal efficacy data are scarce since the vast majority of the studies only focus on their impact on pharmaceutical loads.
The most hazardous representatives among these pollutants are those with a very powerful pharmacological action. Among them, the class of cytostatic (antineoplastic) drugs, used to prevent or inhibit the growth of malignant cells or tumors, can display severe negative effects on nontarget organisms including humans, like carcinogenicity, cytotoxicity, genotoxicity, mutagenicity and teratogenicity (Kosjek et al. 2013). 5-Fluorouracil (Fig. 1) belongs to the subclass of antimetabolites, and its consumption reaches the range of tonnes in Europe. Several studies have reported its presence in natural water at concentrations ranging from ng L−1 to μg L−1 (Lutterbeck et al. 2016).
The fundamentals and reactivity of electro-Fenton process are well described elsewhere (Brillas et al. 2009). Electro-Fenton has been successfully employed for the treatment of acidic aqueous solutions containing antibiotics, antidepressants or β-blockers, among others, using undivided electrolytic cells with different anodes (Sirés et al. 2010; Dirany et al. 2012; Estrada et al. 2012; Panizza et al. 2014; Salazar et al. 2017). However, there have been no studies dealing with the application of electro-Fenton to the degradation of cytostatic agents. Regarding 5-fluorouracil, only a few publications have reported its treatment by AOP, including photocatalysis with TiO2 (Lin and Lin 2014), UV/H2O2 (Lutterbeck et al. 2015), as well as Fenton and photo-Fenton processes (Governo et al. 2017; Koltsakidou et al. 2017). In this context, the aim of the present work is to optimize the key operation parameters for a fast drug decay and large mineralization of aqueous solutions of the emerging pollutant 5-fluorouracil by electro-Fenton using a BDD/carbon felt cell, trying to confirm the great oxidation power of this method to treat highly biorecalcitrant molecules.
The cytostatic drug 5-fluorouracil was of analytical grade (purity higher than 99%) from Sigma-Aldrich, and it was used as received. Solutions were prepared with ultra-pure water obtained from a Millipore Simplicity 185 water purification system with resistivity higher than 18 MΩ cm. Iron(II) sulfate heptahydrate used as source of Fe2+ ions (catalyst) and sodium sulfate added as supporting electrolyte were of analytical grade from Acros Organics and Sigma-Aldrich, respectively. Sulfuric acid from Merck was added to adjust initial pH of all solutions. Salts used as standard in ion chromatography were of ACS grade (purity higher than 99.5%) from Sigma-Aldrich. Methanol used as organic solvent for high-performance liquid chromatography (HPLC) was purchased from VWR.
A bench-scale, open, undivided glass cell was used in batch operation mode at room temperature to carry out galvanostatic electrolyses using an HM8040-3 Hameg power supply. The cell was filled with 200 mL of a 0.1 mM drug solution containing 0.05 M Na2SO4 and a given amount of FeSO4, at pH 3.0 since it is the optimal value for performing electro-Fenton treatments (Brillas et al. 2009). A carbon felt cathode (18.5 cm × 4.5 cm) from Carbone-Lorraine was placed covering the inner wall of the cell, and a PTFE mesh was used to keep it apart from the anode, a thin film BDD on niobium substrate (6.0 cm × 4.0 cm) centered in the cell. The solution was saturated with O2 by sparging compressed air at 1 L min−1, starting 15 min before electrolysis, and continuous stirring (450 rpm) was maintained during the trials. The experiments were run in triplicate.
Drug decays were monitored by reversed-phase HPLC using a Merck Lachrom chromatograph fitted with a Purospher Star RP-18, 5 µm, 25 cm × 4.6 mm (i.d.), column at 40 °C and coupled with an Elite Lachrom L-2400 UV detector selected at λ = 277 nm. Analyses were carried out isocratically by using a 5:95 (v/v) methanol/water mixture, both with 0.1% acetic acid, at 0.4 mL min−1, employing the EZChrom Elite 3.1 software. In competition kinetics experiments (see Panizza et al. 2014), the HPLC analysis was made with a 30:70 (v/v) methanol/water solution (0.1% acetic acid in each) as mobile phase at 0.3 mL min−1. Short-chain carboxylic acids were determined by ion-exclusion chromatography using the same equipment, with a Supelcogel H, 9 µm, [25 cm × 4.6 mm (i.d.)] column at room temperature, the detector set at λ = 210 nm and using 1% H2SO4 as mobile phase at 0.2 mL min−1. Inorganic ions were analyzed on a Dionex ICS-1000 chromatograph that included self-regenerating suppressors. The system was equipped with a DS6 conductivity detector containing a cell heated at 35 °C. An anion-exchange column (IonPac AS4ASC, 25 cm × 4 mm) fitted with an IonPac AG4A-SC column guard was used to analyze the anions. For cations (NH4 +), a cation-exchange column (IonPac CS12A, 25 cm × 4 mm) fitted with an IonPac CG12A column guard was used. A mixture of 1.8 mM Na2CO3 and 1.7 mM NaHCO3 at 2.0 mL min−1 and a 9.0 mM H2SO4 solution at 1.0 mL min−1 were eluted as mobile phases. The mineralization of each solution was monitored from the total organic carbon (TOC) abatement, using the non-purgeable organic carbon method with ± 2% accuracy, determined on a Shimadzu VCSH analyzer. The average values with an error below 2% are reported in all figures.
Results and discussion
Optimization of electro-Fenton parameters for 5-fluorouracil removal
Mineralization of 5-fluorouracil solutions and by-products generated
The fastest destruction of cytotoxic drug 5-fluorouracil by electro-Fenton process (6 min at 300 mA) was reached at an optimum Fe2+ concentration of 0.2 mM. Regarding the mineralization of 5-fluorouracil solutions, the application of 1500 mA ensured the abatement of more than 94% TOC. The second-order rate constant (k abs) for oxidizing this drug with hydroxyl radical was determined for the first time. Electro-Fenton process is shown as highly effective for destroying cytostatic pharmaceutical residues in water.
O. Ganzenko thanks financial support from European Commission (EPA No. 2010-0009) through the Erasmus Mundus Joint Doctorate Programme (ETeCoS3).
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- Koltsakidou A, Antonopoulou M, Sykiotou M, Evgenidou E, Konstantinou I, Lambropoulou DA (2017) Photo-Fenton and Fenton-like processes for the treatment of the antineoplastic drug 5-fluorouracil under simulated solar irradiation. Environ Sci Pollut Res 24:4791–4800. doi: 10.1007/s11356-016-8138-3 CrossRefGoogle Scholar
- Lutterbeck CA, Wilde ML, Baginska E, Leder C, Machado EL, Kümmerer K (2015) Degradation of 5-FU by means of advanced (photo) oxidation processes: UV/H2O2, UV/Fe2+/H2O2 and UV/TiO2—comparison of transformation products, ready biodegradability and toxicity. Sci Total Environ 527–528:232–245. doi: 10.1016/j.scitotenv.2015.04.111 CrossRefGoogle Scholar
- Lutterbeck CA, Wilde ML, Baginska E, Leder C, Machado EL, Kümmerer K (2016) Degradation of cyclophosphamide and 5-fluorouracil by UV and simulated sunlight treatments: assessment of the enhancement of the biodegradability and toxicity. Environ Pollut 208:467–476. doi: 10.1016/j.envpol.2015.10.016 CrossRefGoogle Scholar
- Martín J, Camacho-Muñoz D, Santos JL, Aparicio I, Alonso E (2012) Occurrence of pharmaceutical compounds in wastewater and sludge from wastewater treatment plants: removal and ecotoxicological impact of wastewater discharges and sludge disposal. J Hazard Mater 239–240:40–47. doi: 10.1016/j.jhazmat.2012.04.068 CrossRefGoogle Scholar

domain: chemistry


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All Gods Angels Dog Collar
Leather dog collar with lead free pewter dog angel stamped with "All Dog's Angels Come to us Disguised".
Leather Colors: Black, Black Studded, Brown, Brown Studded
Sizes: Measure your dog’s exact neck size. For medium and large dogs, please add 4” for correct collar size.
This item is custom made to order and is not eligible for return/exchange. Please allow 7-10 days for fabrication.

domain: pet


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Have a Tax Question? Ask a Tax Expert
Thanks for your question. Sorry to hear about your situation. Passive losses wipe out passive activity income -- except when you dispose of an activity you can take the suspended loss the year of the disposal. The COD income would not be able to use passive loss against it if the COD income
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Lake Merritt / Jack London Homes for Sale and Real Estate
Not too far from Oakland’s vibrant downtown core, a diverse community of city dwellers takes refuge from the bustle of the surrounding neighborhoods to find sanctuary near the beautifully restored area of Lake Merritt.
Lake Merritt’s residents include trendy San Francisco transplants, young families, and long-time ‘Merritters.’
With a number of diverse and lively neighborhoods surrounding Lake Merritt, there is ample opportunity to find an area that speaks to you and your lifestyle.
The large number of cafés and restaurants popping up at every corner; the surprising affordability; and the incredible lake access. Finding a home near Lake Merritt and the surrounding neighborhoods is a growing trend for those looking to trade in high San Francisco rents for owning a home.
Search the AreaSearch for homes in Jack London
Around the Area
Around the Lake Merritt Area:
The obvious thing to do while touring the area’s surrounding neighborhoods is, of course, the lake itself. Bike or take a calming stroll around the lake, or, if you’re so inclined, grab a friend or two and hit the water with a rented paddle boat. Don’t miss a visit to the Grand Lake Theatre. locals and tourists interested in taking in the theatre’s breathtaking architecture. Portal is a local hotspot serving up contemporary sake cocktails and locally sourced foods. Did we mention their open-air beer garden, bottomless mimosas and hefty craft beer selection? If you’re near Lake Merritt on a Saturday, be sure to check out the Grand Lake Farmers’ Market and taste fresh local produce, meats, cheeses, and take your pick from the bevy of food trucks that convene there.
Around the Jack London Area:
At the heart of one of the most well-known commercial districts in Oakland, the waterfront neighborhood of Jack London draws in a mixed crowd of tourists and residents as they tour the sights and sounds of the harbor’s waterfront district. The name originally comes from Jack London Square, the main commercial district of this Oakland neighborhood. It’s here where you can find an array of 1950s warehouses converted into hip storefronts, coffee shops and quality dining spots.
The coffee…The people of Jack London know their way around a pour-over. Grab a coffee at notable cafés Blue Bottle Coffee, Bicycle Coffee (they have free pour-overs every Friday!), and Café Santana. The main commercial hub, Jack London Square, is filled with dining spots, local shops, and outdoor activities. Rent a kayak or canoe and tour around the harbor, or walk along the pier and check out some of the amazing boats and yachts docked out on the water.


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Microsoft to bring “good” copy-and-paste implementation to Windows Phone 7
We’ve heard official confirmation that Windows Phone 7 (notice the “Series” is gone) will lack copy-and-paste and that it was an “intentional design decision” because no one actually uses the feature. According to Tweakers.net, however, Microsoft’s Charlie Kindel said that the company’s working on it and will build a “good” implementation for WP7. Here’s what he apparently said during his DevDays Keynote in The Hague:
“We look at this case and we will do the right thing. … We’ve heard your feedback loud and clear.”
It’s still not clear whether copy-and-paste is slated for the initial release of Windows Phone 7, but at least it now seems like Microsoft’s working on it.


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After hosting Black Girls Rock last year alongside Regina King, our favorite girlfriend Tracee Ellis Ross is making a fabulous return to Black Girls Rock as this year’s host.
The BET Networks and Beverly Bond-powered annual show is what #BlackGirlMagic is about — “representing a revolutionary landmark in media as it delivers edifying, entertaining and inspiring content honoring the nexus of achievements made by powerful Black women and girls.”
This year, ShondaLand producer and writer Shonda Rhimes (Shot Caller Award), R&B legend Gladys Knight (Living Legend Award), The Walking Dead actress and Eclipsed playwright Danai Gurira (Star Power Award), award-winning actress and activist Amandla Stenberg (Young Gifted and Black Award), and Black Lives Matter founders Patrisse Cullors, Alicia Garza, and Opal Tometi will all to be honored at this year’s exciting event. And of course, there will be some special musical performances, too.
“I am so proud to once again host “w!™”,! Ross said in a press release.
“What an incredible night celebrating Black women in a show dedicated to Black Girl Magic. Powerhouses Debra Lee, CEO and Chairman of BET Networks and Beverly Bond, CEO of ‘Black Girls Rock! ™’ are true examples of Black Girls who Rock. I’ve proudly hosted this show since before it was televised, and it’s been an honor to be connected to this show for so long. In its 10th year, this show is of utmost importance in today’s times as it highlights positive reinforcement and representation for young black women. I am looking forward to once again being a part of such a wonderful night celebrating the beauty, talents, and accomplishments of black women – it will be a show to remember!”
Black Girls Rock will be taped on Friday, April 1, 2016 at the New Jersey Performing Arts Center in Newark, NJ and will air on Tuesday, April 5, 2016 at 8:00 P.M. ET/PT.

domain: celebrity


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