text:
It has now been 10 days since the Capitals' latest young breakthrough, Cody Eakin, made his NHL debut against the Anaheim Ducks. He has already impressed and made his mark on the scoresheet, with a goal and two assists through three games. He has played so well the Caps appear to be having second thoughts about returning him to the AHL's Hershey Bears.
Speaking of the Hershey Bears, they have made a strong start to the season. The team is deep with seemingly NHL-ready talent, and the question on the minds of most Caps fans and followers is: Who will be the next player make his debut with the Caps?
Patrick McNeill has been called up to the Caps in the past, but has yet to make his NHL debut.
With the emergence of some of the young Caps in recent seasons, his debut is unlikely to come this season. For now, McNeill will likely continue to be one of the key players with the Hershey Bears, but should see his chance come with the NHL club soon.
After next season, the 24-year-old is a free agent, and if he hasn't broken through with the big league club by then, it won't at all be surprising to see him leave, much like Andrew Gordon, and sign elsewhere in the pursuit of his NHL dream.
When the Capitals drafted Evgeny Kuznetsov with the 26th overall pick in the 2010 draft, they knew they were getting a highly skilled player who had top-line NHL potential. Since then, he has developed into one of the NHL's top prospects.
While 'Kuzya' has remained covert about his NHL plans, it would be shocking if the Russian forward didn't make the jump to North America after this season. The Capitals have big plans for his future. They want him to come over, and with a team featuring Alex Ovechkin, Alexander Semin, and Dmitry Orlov, general manager George McPhee has plenty of bargaining power on his side.
The midweek trade that sent Francois Bouchard to the New York Rangers for defenseman Tomas Kundratek could well turn out to be a steal for the Caps.
The Prerov-native, who was drafted in the back end of the third round of the 2008 NHL entry draft, is a physical defensive defenseman who brings a different dimension to the Caps prospect pool. He'll step in with the Hershey Bears for the rest of the year, but with a strong training camp, he could very well crack the Caps roster heading into the 2011-12 season.
There is a good chance he makes his NHL debut as an injury replacement later on this year.
The Capitals' capture of Swedish forward Mattias Sjögren could well turn out to be the most underrated signing of the summer. The 23-year-old forward has kicked off the season with the Hershey Bears, emerging quickly as one of their more important players. He is a physical forward who could well add that final piece of grit to the Caps' puzzle that they need so much.
Should one of their bottom line forwards go down with an injury this season, Sjögren could well win a call-up. Look for him to start the 2011-12 season with the big league.
Since being drafted in the second round of the 2009 NHL draft, Dmitry Orlov has emerged as a premier prospect for the Capitals. He stayed with the Caps out of training camp before becoming the last player to be cut—a testament to the Caps' high rating of him.
As soon as a hole opens up on the blue line, Orlov will be called up to fill it. Nobody knows how long that will be, but Orlov making his NHL debut this season seems inevitable. He'll have a battle on his hands in Camp next summer, but he is expected to come out of it with a spot on the full roster. Stardom is not far away for the young Russian.
Get all the latest news on all the Capitals prospects on Twitter at @CapsProspects


Luxembourg exceeded European Union targets for international development assistance last year, a new analysis shows, bucking an austerity trend that could see Europe fail to meet its long-standing commitments to the world’s poorest nations.
The tiny country spent the least of the EU’s major donor nations, $413.4 million (€316.2 million) and just 0.48% of overall EU development aid in 2011.
But at 0.97% of gross national income, Luxembourg was well ahead of the EU’s overall 0.7% target and second only to Sweden in aid as a percentage of GNI, Organisation for Economic Co-operation and Development (OECD) data show.
The EU is collectively the largest aid donor, providing $86 billion (€66 billion) from national governments and EU institutions – or 55% of the world total in 2011, according to OECD figures.
European leaders have traditionally seen overseas aid as an extension of their “soft power,” agreeing to provide annual development aid equivalent to 0.7% of gross national income by 2015.
Criticism of austerity
But austerity measures could cost the EU’s aid budget nearly €10 billion for the seven-year period running from 2014 to 2020 under the latest proposals being discussed by EU leaders at their November summit in Brussels.
This has drawn criticism from anti-poverty groups that fought for years for heftier aid budgets. Several countries, including debt-plagued Spain, Portugal, Greece and Ireland, have backslided on their aid spending, OECD data show.
“Cutting aid to the world’s poorest countries by almost 10% is a damaging attempt to balance the EU’s budget on the backs of the world’s poor,” Natalia Alonso, who heads Oxfam International's EU office, said in a recent statement.
After an inconclusive meeting, national leaders postponed the tough budgetary decisions until early 2013. Concord, the European confederation of relief and development organisations, has urged EU leaders to use the delay to rethink looming cuts to overseas aid.
And in its new AidWatch report, Concord calls for better coordination to improve financial efficiency.
“The 27 EU states and the European Commission each have their own aid programmes, a situation which this report shows is creating expensive bureaucracy and unnecessary duplication increasing the costs of administration for recipient countries,” Luca De Fraia, member of AidWatch and ActionAid Italy, said in a statement. “Better coordination between the Commission and member states could greatly improve aid quality.”
Luxembourg spent €603 for each of its 517,000 residents in 2011. The country’s aid spending rose from $402.7 million (€308 million) in 2010 to $413.4 million (€316.2 million) in 2011, but as a percentage of national income, it actually declined from the 1.05% to 0.97%.
Sub-Saharan African nations were the biggest beneficiary of Luxembourg’s aid though Vietnam, Nicaragua and El Salvador were also recipients. Overall, Sub-Saharan Africa received nearly $120 million (€92 million), or 29% of aid, followed by Asia and Oceania at 10% or $42 million (€32.1 million), and Latin America and the Caribbean, 8% or $35 million (€26.8 million).
The OECD analysis of Luxembourg, released on Monday (3 December), praised the country’s commitment to aid, but also recommended that it improve its concentration in specific areas and countries to get more impact for its money. The recommendations are in line with proposals made by the European Commission’s Agenda for Change development programme that would reduce aid to middle-income countries while strengthening funds for the most impoverished nations.
EU’s main donors
The EU’s main donor nations have committed to providing 0.7% of gross national income to development assistance by 2015. Four have exceeded the target, OECD figures show. Here is a rundown of where they stand in 2011, ranked by total contribution:
% of GNI
|Germany||$14.5 billion||€11 billion||0.40%|
|United Kingdom||$13.7 billion||€10.5 billion||0.56%|
|France||$12.9 billion||€9.9 billion||0.46%|
|Netherlands||$6.3 billion||€4.8 billion||0.75%|
|Sweden||$5.6 billion||€4.3 billion||1.02%|
|Spain||$4.2 billion||€3.2 billion||0.29%|
|Italy||$4.2 billion||€3.2 billion||0.19%|
|Denmark||$2.9 billion||€2.22 billion||0.86%|
|Belgium||$2.8 billion||€2.1 billion||0.53|
|Finland||$1.4 billion||€1.1 billion||0.52%|
|Austria||$1.1 billion||€842 million||0.27%|
|Ireland||$904 million||€692 million||0.52%|
|Portugal||$707.8 million||€541.5 million||0.29%|
|Greece||$424.8 million||€328 million||0.11%|
|Luxembourg||$413.4 million||€316.2 million||0.97%|


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When it comes to barbecue, no one is does it like how the Texans do. However, despite Dallas being in a great location of being the center of great Texan barbecue, finding a great place to have awesome barbecue in Dallas is actually pretty hard. So, instead of getting disappointed especially when heading to Dallas with high expectations, rental bus visitors should take note on these few places where you can get the best barbecue in Dallas.
Best Barbecue in Dallas (and surrounding areas)
- Off the Bone BBQ, Forest Hill
- Randy’s Bar-B-Que, Red Oak
- Longoria’s BBQ, Fort Worth
Read more here...


text: Looking for some cooking classes in OC, especially North OC. Hands on would be even better (many are hands off). I've been to Zov's and it really isn't my thing. Yves' has some but they are hands way off. Not looking for basic stuff, but rather, something at a higher skill set. Any suggestions?

domain: hobby


Yellen says US economy well on the way to post-COVID recovery
Treasury Secretary Janet Yellen said the U.S. is “well on the way” to a strong recovery from the COVID-19 pandemic, and urged lawmakers to turn to addressing long-run problems ailing the economy.
Yellen said in testimony before the Senate Finance Committee Wednesday that she came into her job in January hoping to help Americans “make it to the other side of the crisis.”
“Thanks to this Congress — and its passage of the American Rescue Plan — I believe we are well on our way towards that goal,” she said, referring to the $1.9 trillion pandemic-relief bill enacted in March.
Still, the country faces challenges in wage inequality, declining labor force participation, racial gaps and climate change, she said. Facing those issues requires substantial public investment, she said, urging lawmakers to back President Joe Biden’s proposals for a multi-year $4 trillion spending plan on child care, infrastructure and green investments.
The hearing came amid an effort by a bipartisan group of senators to hash out a compromise infrastructure plan that would deliver on a portion of Biden’s proposals. Democratic lawmakers in the meantime are also preparing for a fast-track bill that would forgo the need for Republican support by wrapping in spending and revenue proposals that cannot win cross-party backing.
The Biden administration has proposed a series of tax increases on companies and wealthy Americans to pay for the proposals. Republicans have rejected raising levies, however.


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domain: food


text:
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
- Squamous Cell Carcinoma
- Good Clinical Outcome
- Neck Squamous Cell Carcinoma
- Tumor Infiltrate Lymphocyte
- Optimal Tumor
Prognosis varies dramatically in head and neck squamous cell carcinoma (HNSCC) based on HPV status. In HPV+ patients, programmed death (PD)-1 expression has been linked to a better clinical outcome. We hypothesized that extent of PD-1 expression may differentially impact T cell phenotype, patient prognosis and response to anti-PD-1 immunotherapy in a murine HPV+ cancer model.
Material and methods
Freshly isolated tumor infiltrating lymphocytes (TIL) from HNSCC patients were stained by flow cytometry for expression level of PD-1 expression (PD-1high vs. PD-1low), granzyme B, or IFN-y secretion by ELISPOT. The prognostic impact of PD-1high vs. PD-1low T cells was determined in a cohort of HNSCC patients (n=56, median follow up=19 mo). In a murine HNSCC model, PD-1high and PD-1low fractions were compared from CD3+ CD8+ PD-1+ cells and analyzed according to different treatment groups (untreated, anti-PD-1 mAb, radiotherapy and 3 different anti-PD-1/radiotherapy combinations).
CTLA-4 and PD-1 were significantly upregulated on both HPV+ and HPV- HNSCC patients' TIL, whereas PD-1+ CD8+ cells were significantly enriched in TIL from HPV+ patients (p=0.006). Interestingly, PD-1high cells represented a more dysfunctional phenotype, with severely compromised IFN-γ secretion (phigh CD8+ TIL were more likely to be HPV- and had a worse disease free survival (HR = 2.25; 95% CI = 1.46 – 3.15; p < .0001), while high fractions of PD-1low T cells were associated with better clinical outcome (HR= 0.19, 95% CI = .07 - .49, p = .0006), and were seen preferentially in HPV+ HNSCC patients. In the murine HNSCC model, anti-PD-1 mAb plus radiotherapy resulted in optimal tumor elimination, which was associated with an elimination of PD-1high CD8+ T cells and – most importantly – increase in PD-1low/intermed T cell frequencies (p < 0.5).
Consideration of different PD-1 expression levels on TIL segregates PD-1 expression as a marker of activated, competent tumor reactive T cells on the one hand (low/intermed expression), and as a marker of exhausted, dysfunctional cells in the tumor microenvironment on the other hand (high expression). These results emphasize the crucial role of differential PD-1 expression levels on HNSCC patients' effector T cells for prognosis and as a potential novel biomarker for anti-PD-1/PD-L1 based immunotherapy.

domain: biology


As you might expect the most common subjects on airgun forums are the features and foibles involving the dozens and dozens involving different models, yet following closely at the rear of the model discussions is the chatter about airgun ammunition or pellets. You may not expect that a. 177 caliber pellet coming from Manufacturer A would likely perform wildly various from a. 177 caliber pellet through Manufacturer B throughout the same airgun, but they carry out. To be able to even even more complicated Manufacturer B’s ammo may overcome Manufacturer A’s throughout a different air rifle or pistol.
We will discuss a few of the different characteristics of airgun pellets and just how you may use this info to your advantage when selecting a pellet regarding your air firearm or pistol.
The lighter pellet will certainly leave the gun barrel of an airgun faster than a new heavier pellet in addition to it will furthermore accelerate faster downrange. That means less moment to target plus a flatter trajectory because there is less time regarding gravity to function its magic. A heavier pellet will tend to have got a less level trajectory not due to the fact of its weight but because it spends more moment to target offering gravity with extra the perfect time to pull it on the earth.
The particular second factor that will most affects the flight of a good airgun pellet is definitely air resistance. Air resistance increases with the cube involving speed. Once you multiply the speed of your pellet moving downrange you increase it is air resistance by eight times. Genuinely light. 177 quality pellets lose power due to air resistance so rapidly any time a thirty-five yd. or therefore it will be moving slower compared with how a heavier pellet fired from your same gun. Air resistance is probably less relevant for target taking pictures out to 10 m but it would play a big role within a hunting photo beyond that collection. This is one of the reasons that you would like to hunt with the heaviest pellet your airgun will manage effectively.
In add-on to the pounds of the pellet air resistance will certainly vary in line with the condition of the pellet. Wadcutters are toned nose pellets employed for paper target firing. At the 10 michael range the raise in air weight is almost negligible but the same as with all the effect of weight beyond 35 yd. the flat nose begins working like an air brake.
Method weight round nasal area pellets offer the best compromise with regard to both weight in addition to shape for medium powered air rifles. For small quality and reliability air rifles (. 177 and. 20) the best camping ammo is some sort of round nose hollowpoint. This pellet steps from the air simply because well as some sort of regular round nasal area and mushrooms on impact significantly growing the force regarding the shot.
The particular best advice concerning air rifle rounds is to consider a number of different brands, a number of different shapes, plus several different weight load. What you study inside the airgun message boards could possibly be true usually but may not really work for the air rifle. Should 45 acp bulk ammo be only an occasional shooter and nevertheless want the best precision and range next choose a premium pellet from the particular same manufacturer of which made your weapon. Lady best in order to avoid no-name offers because there could possibly be significant variability among pellets in the same package.


Looks like Mavrix Photo is cashing in on their recent peep show with Britney Spears on her topless yachting adventure in Miami recently. The site is selling a package featuring 100 pictures of the event for $9.99. Throw in another $6 and you can get a 5 minute video to boot. Careful though, the site warns, “You CANNOT post these images on websites, chat rooms, message boards, clubs, forums newsgroups, webrings, communities. NO WEB USAGE ALLOWED!”
You can adjust all of your cookie settings by navigating the tabs on the left hand side.


text:
this is purely money over conservation, we have provided proof beyond doubt.
Even before the press have released there findings Bob Lawrence has been selling animals to circuses and private collectors like Amazing Animals. The staff within the park have provided statements of Bob Lawrences, horrors such as "canned" hunting of lions, skins been sold, Misuse of Immobilion, Attacks on staff by animals including snakes and lions and pending court cases against him. Now the press have finally lifted the lid on the "True" goings on of the very famous head warden...
Statements can be presented if needed
c h started this petition with a single signature, and now has 714 supporters. Start a petition today to change something you care about.

domain: law


text:
Grim tally: The faces of Utahns who died at the hands of others in 2012
James Mitchell »47 of 47 «
HELPER, Carbon County, Dec. 23 — James Mitchell, 31, was shot and killed after police say Jeromie Bunch, 30, of Helper, walked from his residence to the home of his estranged wife a few blocks away at 118 Bryner St. Once there, investigators said he confronted Mitchell on the back porch and shot him with a handgun. Bunch then fled into a garage on the property and killed himself. Five children were in the home at the time — Mitchell's three young daughters and the Bunches' two sons. Bunch's wife protected them by gathering them into a room to keep them safe, police said.
»47 of 47 «
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domain: news


text:
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Nestled in the serene neighbourhood of Chambord, La Montagne, this exceptional 3-bedroom flat on the first floor offers a harmonious blend of comfort, style, and investment potential. As you step into this north-facing residence, you're greeted by an atmosphere of tranquillity.
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In a limited market, this property stands out as an invitation to secure your place in a sought-after community. Don't miss your chance to own a slice of modern elegance, panoramic views, and investment success in Chambord. Enquire now to embark on a new chapter of refined living and sound investment.

domain: design


BINDER climate chambers stand out when testing material behaviors under constant temperature and humidity conditions. They are fully compliant with ICH guidelines and offer the best solution for stability testing of active pharmaceutical ingredients at 40 °C and 75% humidity as well as for numerous other applications.
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The radioactive sinkhole in Louisiana’s Assumption Parish continues to grow. It is now 640 feet wide and there is speculation it could grow to at least 1400 feet. It is not on top of the salt dome but beside it which is raising some questions. It swallowed a rescue boat but all crew members were saved.
It seems there are always surprises in store when dealing with the area around the Gulf of Mexico. Thousands of dead fish just washed up around Galveston and a lake in Texas turned blood red as also happened in France for some reason.
The New Madrid fault zone reaching into the Gulf of Mexico and it’s many salt domes is something touched on before. In fact deep water horizon was the result of drilling into salt dome. In fact we can see in the pictorial, the New Madrid is aligned with the Baton Rouge, Assumption Parish sinkhole area. The Jack Reed theory dealt with the Gulf being seismically active with fault movement and earthquakes occurring. He also felt the area was the bottom end of what is known as the New Madrid fault, a fault zone which harbors 12 nuclear reactors along the Mississippi area.
In fact Dr. Gagliano of LSU testified before a senate committee that breaks in recent dikes along the New Orleans area were connected to the seismic fault lines.
Previously a Louisiana blogger indicated that when she first heard of this, she knew somehow that Texas would be mixed up in it. This is an update and the previous post is below.