text:
They co-starred in nine films and had a love affair that spanned decades, many calling it the worst-kept secret in Hollywood, but Spencer Tracy and Katharine Hepburn didn't even like each other when they first met.
Introduced while filming Woman of the Year in 1942, a then-34-year-old Hepburn remarked to her leading man: "I fear I may be too tall for you, Mr. Tracy."
Someone else on set assured the actress 41-year-old Tracy would "cut her down to size".
A divorcee with a liberal background and no-nonsense attitude, Hepburn didn't much impress the more conservative and religious Tracy when they first met, but as soon as they got in front of a camera their chemistry was palpable.
Their witty banter and lingering looks were Hollywood gold, and the pair would go on to star in eight more films together, much to the delight of studio executives and fans.
"On screen, Spencer and I are the perfect American couple," Hepburn once said. It was a different story off-screen.
The pair were drawn to one another, but Tracy was already married and his Catholic upbringing meant divorce was never an option.
Hepburn, who had already been married once herself, didn't seem to mind and never pushed for Tracy to leave his wife for her, content to take second place in Tracy's life.
Hepburn later wrote of Tracy in her autobiography Me: Stories of My Life: "It was a unique feeling I had for him… I would have done anything for him."
They began an affair that would carry on for almost 30 years, hidden from the press and public by careful planning and studio interference.
Dubbed one of the worst-kept secrets in Hollywood history, the couple never publicly acknowledged their romance and went to great lengths to keep it hidden.
Tracy quietly separated from his wife, then reconciled, but spent decades living apart from her, both to protect her from his affair and to keep it hidden from the public.
But the rest of Hollywood – and certainly anyone who ever worked with Hepburn or Tracy – knew what was really going on.
"Everybody left them alone in their little private world."
Lauren Bacall, who along with husband Humphrey Bogart was close with both Hepburn and Tracy, once wrote that her fellow actress was "blindingly" in love with Tracy.
Having lived a Hollywood romance of her own – albeit, a very different one – Bacall recognised how deeply Hepburn had fallen for Tracy, and how deeply she would remain in love with him until his death.
Meanwhile, Hollywood icon Gene Kelly recalled: "At lunchtime they'd just meet and sit on a bench on the lot. They'd hold hands and talk—and everybody left them alone in their little private world."
But Hepburn and Tracy's affair wasn't without challenges, both from the nature of the relationship and the stars' own personal demons.
Tracy reportedly struggled with alcohol and infidelity, periodically checking out of his relationship with Hepburn to grapple with his own issues.
Other times, those issues bled into the affair, Berg recounting an incident he claims Hepburn told him about.
"While Kate was trying to put Tracy to bed, he smacked the back of his hand across her face," the biographer said in his book Kate Remembered.
"She said he was so drunk she believed he neither knew that he'd done it, nor that he'd remember."
When asked if she ever considered ending the affair – either because of Tracy's struggles or because she knew he would never leave his wife - Hepburn was candid.
"What would be the point? I mean, I loved him. And I wanted to be with him. If I had left, we would both have been miserable," she reportedly told biographer A. Scott Berg.
So she stayed, and the pair carried on their affair for decades, often spending long stretches of time apart while one or both of them were filming.
It's possible they would have continued on that way for the rest of their lives, if they'd had the chance, but in 1967 their affair was cut short by Tracy's death from a heart attack.
"I wanted to be with him. If I had left, we would both have been miserable."
He had almost died in 1965 from heart disease and only survived by a "miracle" but suffered poor health in the years that followed.
The actor spent his final two years living a quiet life with Hepburn, who looked after him until he woke in the early morning on 10 June 1967 and went to make himself a cup of tea.
"Just as I was about to give [the door] a push, there was a sound of a cup smashing to the floor—then clump—a loud clump," Hepburn recalled in her autobiography.
Tracy had suffered a heart attack and died aged 67.
Hepburn wrote of his death: "He looked so happy to be done with living, which for all his accomplishments had been a frightful burden for him."
After his passing in 1967, Hepburn decided to reach out to his widow Louise Tracy, the woman who Tracy had refused to divorce despite his ongoing affair.
According to Berg, Hepburn wanted to see if she could be of some help to Louise and Tracy's children and said to her over the phone: "You know, Louise, you and I can be friends. You knew Spencer at the beginning, I knew him at the end. Or, we can just go on pretending."
Louise's reply stopped Hepburn in her tracks: "Oh, yes. But you see, I thought you were only a rumour."
A scandalised Hepburn later told Berg of the exchange: "A rumour! Can you imagine? Thirty years her husband isn't there, and she thinks I'm a rumour."
But until Tracy's death, Hepburn really had been just a rumour – or more specifically, a badly kept Hollywood secret.
Neither she nor Tracy had spoken openly about their romance, and she remained tight-lipped for years following his passing out of respect for the Tracy family.
But when Louise died in 1983, Hepburn finally began to open up about what she and Tracy had shared for almost three decades, though she kept many details vague.
"We just passed 27 years together in what was to me absolute bliss," she once said of their relationship.
While their romance wasn't the shining, rose-coloured Hollywood fairy tale that many stars would have preferred, Hepburn had no regrets about her affair with Tracy when she died.
Shortly before her death in 2003, following years of health problems, the 'golden age' star made her feelings known to Berg.
"We just loved each other," she said. "Nothing more to say."


text:
Online Payment User Agreement
Please Read Carefully Before Continuing
THE CITY OF PALO ALTO REQUIRES THAT YOU READ, UNDERSTAND, AND AGREE TO THE FOLLOWING TERMS AND CONDITIONS FOR THE USE OF THIS WEB SITE BEFORE YOU MAY USE IT.
- By using this web site, you agree to pay the amount due toward Library fines and fees. This web site handles payments only for Palo Alto City Library fines and fees . The Palo Alto City Library is a department of the City of Palo Alto. If you have questions regarding your library fines and fees you may call the Library at 650-329-2436, email email@example.com, or visit one of the Palo Alto City Library locations:Children's
1276 Harriet St. Palo Alto, CA 94301
2300 Wellesley St. Palo Alto, CA 94306
270 Forest Ave. Palo Alto, CA 94301
3700 Middlefield Rd. Palo Alto, CA 94303
1213 Newell Rd. Palo Alto, CA 94303
- You understand and agree that the use of this web site to handle a library fine or fee payment does not alter or extend any statutory deadlines. Thus, your failure to make any payment on time or other failure to meet any deadline will not be excused even if related to malfunctions of this web site. Applicable penalties or fees may accrue as a result of failure to pay on time.
- Payment will be applied at the time of the transaction.
- In consideration of your use of this web site, you agree to provide true, accurate, and current information. If you provide any information that is untrue, inaccurate, or not current, or if the City of Palo Alto has reasonable grounds to believe or suspect that such information is untrue, inaccurate, or not current, the City of Palo Alto has the right to terminate your use of any services on this web site.
- You understand and agree that the City of Palo Alto reserves the right at any time and from time to time to modify or discontinue, temporarily or permanently, any services provided on this web site and any conditions of use with or without notice.
- You understand and agree that the City of Palo Alto may, under certain circumstances and without prior notice, immediately terminate your access to this web site. Cause for immediate termination will include, but not be limited to, (a) breaches or violations of this User Agreement or other incorporated agreements or guidelines, (b) requests by law enforcement or other government agencies, (c) discontinuance of services or content modifications to this web site, (d) technical problems or errors, and (e) extended periods of inactivity.
- The City of Palo Alto makes no guarantees, promises, or warranties regarding the accuracy of information and data provided by a section in this web site. You agree and understand that the information and data on this web site are being provided “as-is” without warranty of any kind and that the information and data may be subject to errors and omissions. To the extent permitted by law, the City of Palo Alto disclaims all warranties, including, without limitation, any implied warranties of merchantability, accuracy and fitness for a particular purpose and non –infringement. The user acknowledges and agrees that neither the City of Palo Alto nor any other governmental agency, entity or body nor any vendor or service relating in any way to our online efforts is or will be liable in any way whatsoever for the accuracy or validity of the information provided. There is no guarantee that this on-line payment application will show all of your unpaid fines and fees. Use of this service to submit payment constitutes acknowledgement that the City of Palo Alto and the processor of electronic payments assume no responsibility for data entered by services users. I hereby understand that payment is an admission of liability and I may not be afforded an opportunity to an administrative hearing.
- In no event will the City of Palo Alto, or any other governmental agency, entity or body or any vendor or service provider associated with any of our online efforts be liable for damages of any nature based on any theory of liability, including, but not limited to, contract, negligence or other torts (including intentional torts), which may include, but is not limited to, damages for loss of property, loss of profits, lost, compromised or impaired claims, lost savings, lost fees, or any other damages whatsoever, arising out of or relating to in any way to the use of this web site. Accordingly, you acknowledge and understand that you use this web site at your own risk and that your agreement to this Section 8 is a material inducement to the City of Palo Alto’s decision to make this web site available for your use.
- The on-line payment web site is committed to protecting your privacy. Security measures for this site have been taken to protect against loss, misuse or alteration of the information you provide; and industry standard encryption methods are used to assure security. This on-line payment site does not store any information related to your payment transaction such as name, account number, address or e-mail address and information could never be sold or rented to third parties. Nevertheless, it is crucial that, as a user, you protect against unauthorized access to your password and to your computer and that you always sign off when you are finished with using a shared computer. Further, you should be aware that no system is impenetrable. Thus, it is your responsibility to diligently monitor your credit card statements, bank statements and similar personal information so as to discover and address as quickly as possible any misuse of your personal information.
- Return Policy: In cases where the user believes a charge has appeared on his or her credit card statement by an act of fraud, the user should contact his or her credit card company and that card issuer will then contact the City of Palo Alto. Do not contact the City of Palo Alto directly in this instance. In cases where you believe a duplicated charge to your credit card has occurred, please contact the Palo Alto City Library at 650-329-2436.

domain: law


Water "equivalent" solid
plastic slabs are sometimes used to substitute for water for the measurement
process. These slabs are manufactured to a high degree of precision to
accurately reflect the attenuation of water at all x-ray and electron energies.
A special slab has a cavity which will accept a specific ion chamber.


The Toyota Research Institute (TRI) has unveiled its newest autonomous test vehicle, Platform 2.1, featuring Luminar’s sensing technology. Since coming out of stealth last April, Luminar has scaled up its partnerships with a select few companies – TRI being the first to deeply integrate the new sensing platform.
Luminar’s LiDAR delivers greater resolution than current sensors and the ability to see dark objects, such as a tire (10% reflectivity) at over 200 meters, compared to less than 40 meters. The sensor is also the first to allow resolution to be concentrated where it’s needed most, in real time, enabling the car to clearly see and recognize cars, people, and objects, even at distance.
Luminar has a new approach, it has built all major components in its system from the ground up: lasers, receivers, scanning mechanisms and processing electronics. The architecture requires only a single laser, single receiver, and ultra-fast scanner to collect millions of points of information in the environment from just a fraction of the components used in today’s LiDAR systems


text:
Kopiaste- crust recipe using tahini and digestive cookies. Just a note of the digestive cookies, it's not what you think it is - they are glorified graham crackers also known as wholemeal "biscuits" popular in the UK, Ireland and Greece. I love these biscuits, and always buy them whenever I see them at Papacristos C+K or at ethnic markets in Little Armenia. They look like this:
1 cup pitted cherries
1 package cream cheese
1/3 cup sugar
1 tsp vanilla extract
1/2 package Digestive biscuits
2 tablespoons tahini
1-2 tablespoons melted butter
Preheat oven to 350 degrees. Whirl biscuits in food processor until fine, add tahini and mix again until everything is combined. Empty into a baking vessel. Add melted butter, mixing to combine then press into bottom of pan to form the crust.
Beat cream cheese, sugar, egg and vanilla until fluffy and pour into crust, layering with cherries.
Bake for 40 minutes or until golden brown on top. Chill for at least 2 hours before consuming.

domain: food


On May 19, 2022, a dozen people from across Springfield boarded the 93-year-old reconditioned Ford Tri-Motor 5-AT-B airplane at Springfield Abraham Lincoln Capital Airport. The 1200 horsepower plane first flew in 1928. Affectionately known as the “Tin Goose” the first luxury airliner, the Ford Tri-Motor redefined world travel and marked the beginning of commercial flight, it was the largest civilian passenger aircraft of its time. It was pretty exciting for me to get an up-close and personal look at the Ford Tri-Motor. Most planes at the time still relied on wood, Ford’s planes used metal exterior and wood on the interior trim. The airplane had 3 engines, each putting out over 400 supercharged horsepower.
With engines roaring and propellors spinning, the Ford Tri-Motor took flight, giving passengers a bird’s-eye view of downtown Springfield and Lake Springfield. I really enjoyed the 15 minutes ride over the sky in Springfield. The “City of Wichita” the aircraft’s official title, is one of fewer than 200 Ford Tri-Motors built from 1926-1933, making it the world’s first mass-produced airliner.
The Experimental Aircraft Association organized a series of flights in Springfield on the historic plane for interested people to experience a flight and see the state capitol and Lake Springfield from the sky.
Sangamon Watch Company is launching a new aviation watch collection “The First Flight” end of this year, make sure you bookmark this blog to receive future updates.
You must be logged in to post a comment.


LEE CHIN says it does not matter whose motion tackles racism in the GAA — so long as the issue is addressed.
Wexford’s attempts to have a new rule introduced at Congress have been scuppered by red tape — with their motion ruled out of order.
A similar one by Cavan was also binned.
Motions to change playing rules are only permitted every five years — in years divisible by five — so the next time a county can propose to change a playing rule is 2015.
The GAA, at central level, do have special dispensation to introduce playing rules when they deem them necessary.
But Croke Park chiefs are actually formulating a new all-encompassing motion for the Official Guide that will strongly punish all forms of racist and sectarian abuse — on and off the pitch.
It will go before Congress in Derry in March.
Wexford dual star Chin told SunSport: “It does not matter who brings the motion forward or where it comes from. It just needs to be put forward.
“Everybody knows racism is wrong, no matter what way you look at it.”
Chin brought the matter to national attention last year as he was racially abused while playing for Sarsfields against Duffry Rovers.
Two Duffry Rovers players received suspensions and the same club seconded Sarsfield’s motion last December.
The motion, which was unanimously supported, called for the minimum penalty to rise from eight to 12 weeks.
Wexford spokesman Rory Murphy told SunSport: “We are disappointed it has been ruled out of order, it is especially disappointing for the clubs who put so much work into ensuring the motion was correct.”
The five-year rule is to prevent counties bringing motions annually trying to change playing rules.
Chin said: “I suppose people in Croke Park, they have their hands tied down with that rule.
“But I heard that there are ways around that. They can change rules of the game in cases of emergency and things like that.
“In my opinion something like this is an emergency.
“I don’t know what way they will look at it but for me, the rule they have in motion right now, I don’t think it is strong enough.
“This is why me and Jason Sherlock spoke about it and appeared on The Late Late Show to try and make a difference on that matter. If there is something to make an improvement on the subject, that’s what we are aiming for.
“A rule should be there to tackle it but hopefully it shouldn’t take a rule to make people realise and understand that racism is wrong.
“Even though they ruled out the motion from Wexford and Cavan, I still don’t look at the GAA and think they are putting their heads down and just avoiding it or anything.”
The current penalty for anyone deemed to have discredited the Association ranges from a minimum eight-week ban to expulsion.
The new rule is not going to be more lenient — so those found guilty could still face debarment from the Association while the minimum punishment is also likely to increase.
Chin insists racist abuse does have an impact on players.
He explained: “There are a lot of people out there that you need to have concern for.
“I’m maybe a different character to a lot of others. Jason Sherlock mentioned on The Late Late that he lost confidence in himself and was very embarrassed by it.
“In fairness I do get embarrassed by it but it’s just the character you are and the type of mentality you have that you can get over that.
“Some people out there you have to be curious for. It’s a form of bullying really.”
Chin will be focusing on a Walsh Cup semi-final this Sunday when Liam Dunne’s Wexford face Kilkenny.
The dual star will be playing with the hurlers and footballers this year, but will only be involved in the small-ball game this weekend.
WEXFORD (SH v Kilkenny): N Breen; B Kenny, C Kenny, E Moore; R Kehoe, A Shore, J Tonks; L Chin, E Doyle; H Kehoe, P Morris, G Moore; PJ Nolan, M O’Regan, P Doran.


text:
Background:Since 1990 it was proposed that distal and proximal location of colon cancer might follow different biological, epidemiology, pathology and prognosis, probably due to embryologic different development of the two segments of the colon, which may represent two separate disease entities. These differences might have consequences for the treatment of patients with colorectal cancer. Aim:To compare the characteristics between patients with right and left colon cancer, with severity and tumor characteristic that influence in the survival of these patients. Method:Were evaluated the outcomes of surgical treatment of patients with colon cancer with data collected retrospectively from prospectively collected database. Results:The tumor’s side did not influence survival time of patients with colon cancer (p=0.112) in the regression model. Only the diseases stage leads to influence on survival time; patients with right colon cancer have more advanced staging (III or IV) and present a risk of death greater in 3.23 times. Conclusion:This analysis provides evidence that the prognosis of localized left-sided colon cancer is better compared to right-sided colon cancer. Also, the patients with right colon cancer have more advanced stage, mucinous tumor and are older.
Multiple previously described advantages associated with internal pudendal artery perforator flap were also observed here, reinforcing the idea that it is reliable, versatile, and a useful option for perineal reconstruction after abdominoperineal excision of the rectum. Therefore, we propose that this flap could be considered as the first choice for perineal reconstruction in selected patients with moderate and some large defects after abdominoperineal excision of the rectum. See Video Abstract at http://links.lww.com/DCR/A367.
Background: Indications for colostomy in colorectal diseases are obstruction of the large bowel, such as in cancer, diverticular disease in the acute phase, post-radiotherapy enteritis, complex perirectal fistulas, anorectal trauma and severe anal incontinence. Some critically ill patients cannot tolerate an exploratory laparotomy, and laparoscopic assisted colostomy also requires general anesthesia.Objective: To evaluate the feasibility, safety and efficacy of performing colostomy assisted by colonoscopy and percutaneous colopexy.Materials and methods: Five pigs underwent endoscopic assisted colostomy with percutaneous colopexy. Animals were evaluated in post-operative days 1, 2, 5 and 7 for feeding acceptance and colostomy characteristics. On day 7 full colonoscopy was performed on animals followed by exploratory laparotomy.Results: Average procedure time was 27 minutes (21-54 min). Postoperative mobility and feeding of animals were immediate after anesthesia recovery. Position of the colostomy, edges color, appearance of periostomal area, as well as its function was satisfactory in four animals. Retraction of colostomy was present in one pig. The colonoscopy and laparotomy control on the seventh day were considered as normal. A bladder perforation that was successfully repaired through the colostomy incision occurred in one pig. The main limitation of this study is its experimental nature.Conclusion: Endoscopic assisted colostomy with percutaneous colopexy proves to be a safe and effective method with low morbidity for performing colostomy in experimental animals, with possible clinical application in humans.
Three-dimensional endorectal ultrasound was effective for determining rectal wall invasion and lesion extension in tumors <5 cm and with <50% of rectal wall invasion but was limited for detecting lymph node involvement in early rectal lesions.
scite is a Brooklyn-based startup that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

domain: literature


text:
At PhysioMotion Cairns, we provide numerous services for babies, children and adolescents. Our Physiotherapist Shannon has special interest in Paediatric Physiotherapy. We work closely with local Paediatricians, Doctors, Child Development Service (CDS), Disability Services Queensland (DSQ), Queensland Paediatric Rehabilitation Service (QPRS), Cerebral Palsy League and ARC Disabilities in order to achieve the best outcome for your child. Our team of experienced Physiotherapists can assess and treat various conditions or concerns including the following:
- Developmental Assessments for Babies and Children.
- Head Shape monitoring for babies.
- Severs Disease, Oshgood Schlatters and other growing pains.
- Toe Walking.
- Musculoskeletal injury.
- Sport injury management.
- Neck and back pain.
- Cerebral Palsy.
- Down’s Syndrome.
- Prader Willi Syndrome.
- Low Tone (Hypotonia) and Increase Tone (Hypertonia).
If you have any concerns regarding your baby or child whether it is related to their gross motor development or an injury, please contact our office and one of our friendly Physiotherapists can help you with any enquires.
Our Physiotherapy team are trained in assessment, treatment and long term management of numerous neurological conditions. We pride ourselves on our holistic approach to management by working closely with Doctors, Specialists, other Allied Health Professionals, Families and Carers to achieve the best outcome for each individual. Our Physiotherapists can help with the following neurological conditions:
- Acquired Brain Injuries (ABI) and Traumatic Brain Injuries (TBI).
- Parkinson’s Disease.
- Multiple Sclerosis (MS).
- Cerebral Palsy.
- Guillain-Barre Syndrome.
If you have any queries about other conditions we may be able to assist with, please don’t hesitate to contact our office for further information.

domain: medical


text:
An infamous 'inflammasome'—a rogue protein complex—appears to underlie a rare and disabling autoimmune disorder
Autoimmune diseases are among the most puzzling because turncoat constituents of the body wage a constant state of war. Sometimes the underlying cause of an autoimmune condition is so obscure—hidden within chemical miscues of the body—that a long investigatory search must be mounted to sleuth out a cause.
And so it has been with in-depth research to understand an extremely rare autoimmune disorder. The condition is known as CAPS—cryopyrin-associated periodic syndrome. It afflicts patients with an array of disparate symptoms, ranging from skin rashes to permanent hearing loss.
To understand the disorder, scientists have had to explore the influences of cellular biomechanics and the roles of chemical miscues linked to an infamous inflammasome, a protein complex that triggers extreme inflammatory activity. CAPS, scientists now say, occurs because of an inflammasome that's gone rogue.
Inflammasomes are multi-protein complexes found in the cytosol of cells that rapidly assemble and activate proinflammatory signaling in response to a diverse number of stimuli.
Normally, inflammasomes guard us against infection and cancer by triggering the domino effect of a powerful immune response. But inflammasome activity can also go awry and cause uncontrolled inflammation. Indeed, conditions known as autoinflammatory disorders, like CAPS, can occur when the body creates an immune response without an easily discernable cue, leading to a host of debilitating lifelong symptoms.
Like CAPS, there are other rare autoinflammatory conditions that cause a range of symptoms, from skin rashes to devastating inflammatory responses leading to fever, blindness, deafness, and cognitive decline.
Writing in the journal Science Immunology a collaborative team of researchers at multiple institutions in France sought to find out why—and how—a key inflammasome can careen out of control and produce rare, disabling symptoms.
CAPS, the French team says, is related to the overactivation of a notorious inflammasome—NLRP3—which can be influenced by miscues in mechanical signaling. Mechanical signaling occurs when cells in close contact with each other send errant signals that move through the cytoskeletons of affected cells.
The new research describes how mechanical signaling involving immune cells' membrane proteins can lead to autoimmunity affecting patients with CAPS. The rare disorder, which usually begins in infancy, is marked by waxing and waning lifelong symptoms. It's characterized by rashes, joint pain, red eyes and severe headaches with vomiting. Hearing loss usually occurs during the teen years and is often permanent.
Yet, it has taken until now to figure out the underlying molecular and cellular signaling miscues that lead to full-blown CAPS. Key immune system cells—those of the myeloid family—are also involved in the autoinflammatory condition, scientists have found.
"Immune cells sense the microenvironment to fine-tune their inflammatory responses. Patients with cryopyrin-associated periodic syndrome—CAPS—caused by mutations in the NLRP3 gene, develop autoinflammation," writes Dr. Li Ran, lead author of the new inflammasome research.
Ran is an immunologist at the Institut de Génétique et de Biologie Moléculaire et Cellulaire of Université de Strasbourg in Illkirch, France. The NLRP3 complex, whose gene Ran referred to, is the notorious cell-death inflammasome, which can trigger proinflammatory activity via multiple types of stimuli.
NLRP3 apparently becomes dangerous when its proinflammatory activity can't be switched off. When this happens, it's like having an "on switch" permanently flipped to the "on" position. In addition to CAPS, a mutated NLRP3 inflammasome complex also underlies certain neurogenerative disorders, such as Alzheimer's disease, arthritis, some forms of cancer, and gout.
Ran and colleagues explored some of the many ways a process called mechanotransduction, mediated by the protein PIEZO1, might contribute to the disease-generating activity of NLRP3, allowing CAPS to flourish. Inflammasomes, including the NLRP3 complex, trigger proinflammatory activity through multiple types of chemical stimuli, the scientists found.
In the lab, the team zeroed in on a triggering protein called PIEZO1 and studied its impact on the NLRP3 inflammasome in human macrophages and, additionally, in a mouse model. In the lab studies, the French collaborators discovered that PIEZO1 not only affected NLRP3 but a calcium-activated channel called KCNN4 in myeloid cells, ultimately culminating in an uptick in potassium efflux. This, in turn, propelled NLRP3 inflammasome activation.
But most notable in the lab research was that the team found a way to circumvent the problematic out-of-control proinflammatory activity. Inhibiting the KCNN4 channel in both the human cell lines and the mouse model circumvented inflammasome-triggered autoimmunity.
"Targeting the PIEZO/KCNN4 pathway may provide new therapeutic strategies for the treatment of CAPS patients and potentially other NLRP3-related inflammatory diseases," Ran concludes, noting that these findings might also offer new insights into the control of gouty arthritis, another inflammasome-mediated disease.
More information: Li Ran et al, KCNN4 links PIEZO-dependent mechanotransduction to NLRP3 inflammasome activation, Science Immunology (2023). DOI: 10.1126/sciimmunol.adf4699
© 2024 Science X Network

domain: biology


text:
FREE CONSULTATION PUSH 'LET'S TALK"
FEEL HEARD FEEL BETTER- NO NON-SENSE
How will a Functional Health , Certified Health and Wellness Nurse Practitioner help optimize your life and well-being? Sign up to be informed, get specials, sales, and events, only I get this email!
Move That Mountain Functional Health
Copyright © 2018 Move That Mountain Wellness Coaching - All Rights Reserved.
Powered by GoDaddy

domain: health


text:
Bank Financial Management
Lowest online price: 520.00 442 (15% off)
|Contributor(s)||IIBF (Indian Institute of Banking and Finance)|
0.0 out of 5 stars
Bank Financial Management Price from 1 Online Seller
|Seller||Seller Rating||Est. Delivery||Price||Buying Options|
2 – 4 days
442.00 FREE Shipping
See a problem with these offers?
Let us know
Buy the Bank Financial Management from Amazon.in Marketplace.
The lowest price on Junglee by Amazon for the Bank Financial Management is 442.00 from Amazon.in Marketplace.

domain: economics


text:
Norwood Promotional Products Launches New Line of Stick-To-Notes
Indianapolis-based Norwood Promotional Products announced the company launched Stick-To-Notes, a new line of self-adhesive note pads and cubes. The line includes a variety of sizes and sheet counts, from 25-sheet adhesive pads to 3x3x3" adhesive cubes. The new line of Stick-To-Notes will allow for optional four-color imprint and Norwood is offering free setups and flood coats for custom background colors.
Further, Norwood is offering distributors reduced introductory pricing through the end of the year.
Norwood Promotional Products is an industry leading supplier of imprinted promotional products. The company offers nearly 5,000 products and is a market leader in several of the industry’s major product categories.
For more information on Norwood Promotional Products, visit www.norwood.com.

domain: news


text:
Application Note: Transcriptome Sequencing Using the Ion Proton™ System
19 August 2013
Understanding the structure, function, and organization of information within genomes is central to basic and translational research. With the advent of deep-sequencing technologies, it has become increasingly evident that transcription is an intricate and dynamic process involving a variety of RNA species, including short RNAs, polyadenylated RNA, and nonadenylated transcripts. Transcriptome sequencing is the most complete yet most cost-efficient method for identifying and quantifying RNA from multiple types of starting material. In contrast to microarray analyses that require a priori knowledge of transcripts in a cell for targets to be present on the microarray, transcriptome sequencing provides a hypothesisneutral approach to interrogating all the transcriptional content of a genome. This application note presents a method for transcriptome sequencing on the Ion Proton System from Life Technologies and compares the results to those obtained from microarrays and qPCR.


text:
In a report issued on May 5, Derek Johnston from Deutsche Bank maintained a Buy rating on Federal Realty (FRT – Research Report), with a price target of $143.00. The company’s shares closed last Friday at $115.14.
According to TipRanks.com, Johnston is a 4-star analyst with an average return of 14.0% and a 51.6% success rate. Johnston covers the Financial sector, focusing on stocks such as Independence Realty, Equity Residential, and Medical Properties.
Currently, the analyst consensus on Federal Realty is a Moderate Buy with an average price target of $135.64, which is a 16.1% upside from current levels. In a report issued on May 5, BMO Capital also maintained a Buy rating on the stock with a $145.00 price target.
The company has a one-year high of $140.51 and a one-year low of $109.89. Currently, Federal Realty has an average volume of 480.1K.
TipRanks has tracked 36,000 company insiders and found that a few of them are better than others when it comes to timing their transactions. See which 3 stocks are most likely to make moves following their insider activities.
Federal Realty Investment Trust is an equity real estate investment trust, which engages in the ownership, management and redevelopment of high quality retail focus properties. The company was founded by Samuel J. Gorlitz in 1962 and is headquartered in Rockville, MD.
Read More on FRT:
- Performance Food Group (PFGC) Receives a Buy from Wells Fargo
- Robert W. Baird Sticks to Its Hold Rating for Bank of America (BAC)
- American Express (AXP) Receives a Hold from Robert W. Baird
- Berenberg Bank Thinks Lam Research’s Stock is Going to Recover
- Simmons 1st Nat’l (SFNC) Receives a Hold from Robert W. Baird

domain: finance


text:
Saturday, July 30, 2011
I love it when I have an actual occasion to bake for. I find most of the time I am baking for a baking group assignment or just because I have a compulsion to bake every few days or so. So when I saw my friend Sharon's birthday was coming up on the calendar my mind kicked into to gear to decide what to make for the occasion.
Cupcakes! Everyone loves cupcakes right?
Sharon's favorite cake is vanilla cake with vanilla frosting. I rarely make white cake (since I'm a chocolate girl through and through), so I went in search of recipe. I added Martha Stewart's Cupcakes cookbook to my collection a few months back but had not had the opportunity to break it in. If you can call making one recipe breaking it in...we are now broken. I made her white cupcake recipe. I cheated a bit on the frosting and used Trader Joe's white frosting box mix. And to spruce it up I filled the cupcakes with raspberry jam.
The cake was light and tender. The frosting was super sweet...think buttercream. And the tartness from the raspberry jam brought it all together. Next time I would try a lighter frosting...like this whipped cream frosting. When we ate them I think we all had a major spike in our blood sugar, but they were still tasty!
from Martha Stewart's Cupcakes
3 1/4 cup of sifted cake flour (not self-rising)
1 1/2 tablespoons baking powder
1/4 teaspoon salt
1 tablespoon vanilla extract
1 cup plus 2 tablespoons milk
1 3/4 sticks unsalted butter at room temperature
1 3/4 cups sugar
5 large egg whites at room temperature
Preheat oven to 350 and line muffin tins with paper liners. In a medium bowl, sift cake flour, baking powder and salt and set aside. Stir vanilla into milk and set aside.
Cream butter with an electric mixer on high until smooth. Slowly add in sugar and beat until the mixture is pale fluffy. Reduce speed to low and add flour mixture in thirds alternating with the milk mixture until everything is just combined.
In separate bowl beat eggs whites on medium speed with an electric mixer until stiff peaks form. Fold a third of the egg whites into the batter to lighten the batter. Gently fold in the remaining egg whites in two batches until just incorporated.
Use an ice cream scoop or spoon to fill cupcake liners 3/4 full. Tap muffin tins on the counter top to release any air bubbles. Bake for 18 - 20 minutes, rotating the pans halfway through baking. A toothpick should come out clean. Cool on a wire rack.
To fill cupcakes with raspberry jam, cut a cone shaped hole out of the top center of the cupcake and set it aside. Fill with a teaspoon or so of jam and then replace the cut out piece of cake to fill the hole. To see an example of filling a cupcake, click here.
Top cupcakes with a frosting of your choice.


Quarterly Raffle Flute
Anonymous graciously donated this quarter’s raffle flute. The maker of this Native American-style flute is Dr. Richard Payne. The flute was crafted most likely in the mid-1970s, about 45 years ago. It is made of white oak and has six finger holes. It is a diatonic flute in F, meaning it plays the major scale. According to Dr. Payne, who gave this flute to Anonymous, “Doc” Tate Nevaquaya was going to replace his dining room table. Dr. Payne asked “Doc” Tate if he (Dr. Payne) could have one of the legs from the old table, and “Doc” Tate obliged.” Dr. Payne used the table leg to craft a flute. It is a relatively large flute, 24-inches long, with a 7/8-inch internal diameter and 1.5-inch external diameter, tapering a bit toward the distal end (distal to the mouthpiece). The rim at the distal end has “TOUBAT” burned into the wood. The flute has new leather ties and has been refinished. Also, the copper spacer under the saddle was tarnished but was cleaned, so it looks brand new. The flute has a soft sound.
Tickets are $5 each. You may purchase as many as you desire. The raffle lasts until February 24, 2021. The winner will be announced on February 28, 2021.
Please send funds made payable to:
World Flute Society
20735 Morning Star Road
Lead, SD 57754 USA
Thank you for your support of the World Flute Society!
Last Quarter's Donation Flute
Jim Harris graciously donated last quarter’s raffle flute. The maker of this Native American-style flute is Brad Young of 4 Winds Flutes. It has six finger holes. The flute is in the key of A. It is 19 inches long. The flute plays beautifully.
Thank you, Jim Harris, for your kindness and generous support of the World Flute Society.
Winner: Jessica Auman