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- Comfortable ride
- Longer wear
- Improved handling
- Affordable price
- Weak performance in snowy roads
The Hankook Kinergy ST H735 is primed and ready for 2019! This tire was revealed in 2018 and replaces the Hankook Optimo H727 in the touring category. In some markets, you can still get the Hankook Optimo H727. But if you have a newer car, why place your bets on an older variant when you can get a new and better tire for almost the same price!
The Hankook Kinergy ST H735 is a standard touring all-season tire. It is designed and engineered to offer good year-round traction in changing weather conditions. The primary attributes of this tire are superb comfort, longer wear, and better fuel economy. The secondary attributes are better grip and handling, lower road noise, and stronger braking.
From that alone, it is easy to discern the Hankook Kinergy ST H735 is ideal for compacts, small sedans, and sports coupes. However, it is not designed to offer advanced levels of traction and grip for sporty driving.
Is the Hankook Kinergy ST better than the Optimo H727?
New models will always be better than the old ones. The Hankook Kinergy ST tackled the shortcomings of the Optimo H727 head-on. And while the Optimo H727 offered good grip in the dry, it’s not as good in the wet. And even though it grips dry tarmac fairly well, it fell short in terms of high-speed handling and stability.
In this regard, the Hankook Kinergy ST benefits from several innovations to enhance traction and grip in all-season driving. The Kinergy ST is constructed using an advanced silica-enhanced compound. This not only improves performance in varying temperatures and weather conditions, but it also lowers the rolling resistance to offer better fuel economy and lesser road noise.
Is it good for light snow or ice?
Yes, the Hankook Kinergy ST is a better performer in cold weather or snowy roads. However, particular emphasis should be focused on the word ‘light.’ Anything with more than an inch or two of snow will cause the tire to hunt for grip. It also struggles in the braking department over slippery, icy roads. If you live in places with harsh winters and heavy snowfalls, you are better off with a proper set of winter tires.
What are the features of the Hankook Kinergy ST H735?
Everything about the Hankook Kinergy ST H735 is optimized to be better than the previous Optimo H727. The tire benefits from a strong jointless bead wire and parallel carcass line for a stiffer sidewall. The silica-enhanced compound offers improved abrasion resistance without compromising the all-season traction and grip of the tire.
The Hankook Kinergy ST H735 is equipped with four circumferential grooves. The optimized block stiffness of the tire helps to improve handling and stability. The treads feature optimized traction grooves with wider lateral grooves. This feature enables the tire to bite or grip the surface while enhancing wet braking.
The treads are also equipped with variable-angle sipes with extended kerf lengths to further enhance traction and stability on wet and snowy roads. The tire also comes with blocks on the tie bars to offer better handling, stronger braking, and better high-speed stability.
Does it feel like a sporty tire in the dry?
In some ways, the Hankook Kinergy ST H735 feels like a sporty tire on dry roads. This is due to better handling and more accurate steering. But it is hard to reach the limits of adhesion unless you really coax the tires to lose traction. However, if you have a fast sports car or sports sedan, this tire can get easily overwhelmed by abrupt steering inputs and heavy throttle pressure as you exit the corner.
Suffice to say the Hankook Kinergy ST H735 is far from being a high-performance tire. But as long as you stay below the speed limit, this tire will offer relentless traction on dry tarmac.
How does it perform in wet pavement?
It’s the same story in the wet. The Hankook Kinergy GT will serve dollops of grip on wet highways, but only if you’re gentle with the steering and throttle inputs. But if we’re talking about accurate and stable handling at silly speeds, you’re better off with a set of high-performance rubber.
Is it comfortable and quiet?
The Hankook Kinergy ST is a smooth and silent performer. It excels in straight-line highway driving and stop-and-go traffic. The tire is not easily upset by rough roads or harsh pavement. It even handles potholes like a champ!
However, tire roar is still evident at the upper reaches of the speed limit, but not by much. For all intents and purposes, the Kinergy ST is quieter at speed than the old Optimo H727.
How about tire wear?
This is the biggest advantage of the Hankook Kinergy ST. Touring tires are known for comfort and longer wear, and the same holds true for this tire. In fact, Hankook is confident enough to offer the Kinergy ST H735 with an impressive 70,000-mile treadwear warranty. This is saying a lot about the brilliant wear characteristics of the Kinergy ST.
Should I buy the Hankook Kinergy ST H735?
I can see no reason why you shouldn’t. Besides offering higher levels of comfort and longer wear, the Hankook Kinergy ST H735 is also one of the most affordable tires in Hankook’s lineup. And even though the previous Hankook Optimo H727 may have a lower price tag, you get more features and benefits from the Kinergy ST.
But if you want higher levels of grip and a sportier style, you should focus your sights on the Hankook Optimo H426 or the Ventus V2 Concept 2. Both tires offer more aggressive styling and a sportier driving feel than the Kinergy ST.


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Fishing License and Regulations
Remember to bring your statutory fishing license when fishing with rod and line.
Always remember your fishing license
If you are between 18 and 65 years of age you must be in possession of a statutory fishing licence before going sports fishing in Denmark.
The money raised by sales of fishing licenses goes to releasing fish, rivers and stream restoration projects and research. You can purchase your fishing license at: www.fisketegn.dk.
Minimum size limits
It is well worth being familiar with the minimum size limits for fish, for example 40cm for sea trout, 25cm for plaice and 35cm for cod. If you catch a fish below the minimum size limit you must immediately release it as carefully as possible. Make sure your hands are wet before touching a fish, this helps protect the fish’s protective layer of mucus. It is a good idea to always have a pair of forceps close at hand, so you can unhook the fish as quickly as possible. You can find a table showing minimum size limits on the Danish Farming and Fishing Ministry’s website (In Danish).
In Denmark a number of species of sea-fish are subject to closed-seasons, during which you must release any of these fish you catch. You can find can find details of the closed-season here.
Access to the coast
- Park your car in one of the parking places shown, never park of private land.
- You can walk along the coast at all times of day, but please respect private property by keeping a distance of min. 50m from beach houses etc.
- Wading in shallow water is allowed at all times - also off privately owned beaches.
- Camping in a tent on the beach is not allowed, however if you have a sleeping bag you may sleep under the open sky.
- Camping is only allowed on privately owned land (including privately owned woods) if you have obtained permission from the landowner.
- On public land you can sleep-out overnight with a thermal mat and sleeping bag or in a hammock . You can use a waterproof tarpaulin , as long as it does not come to resemble the character of a tent.
- Ou can find a map showing the location of primitive campsites on www.udinaturen.dk (In Danish) or here on this website.
- Alway take you refuse home with you - or use one of the local rubbish bins.

domain: hobby


text:
Shares of Skyworks Solutions Inc. (SWKS) have been declining since the open of trade Thursday. The stock is now down 2.77 at $20.85 on above average volume.
Skyworks Solutions has dropped to a 1-month low and has fallen below its 50-day moving average.
by RTT Staff Writer
For comments and feedback: email@example.com

domain: news


text:
David O. McKay School of Education. Department of Teacher Education
- Existence: 1997
The Department of Teacher Education was established in 1997 within the David O. McKay School of Education. The department oversees graduate and undergraduate work within the fields of Early Childhood Education, Elementary Education, and Secondary Education. Its goal is to prepare teachers for the workplace.
The department operates under a chairman who reports to the dean of the school. Chairmen have included: M. Winston Egan (1997-2010) and Nancy Wentworth (2010- ).
Citation:BYU organizational history, via WWW, Feb. 26, 2013 (Department of Teacher Education; est. 1997; part of David O. McKay School of Education; chair: M. Winston Egan (1997-20100) and Nancy Wentworth (2010- ); oversees undergraduate and graduate coursework in Early Childhood Education, Elementary Education, and Secondary Education)
Brigham Young University, via WWW, Feb. 26, 2013 (Brigham Young University; Teacher Education faculty and staff)
Found in 6 Collections and/or Records:
Department of Teacher Education administrative meeting minutes, 2006-2007
Contains the materials related to meetings between chair M. Winston Egan and the school dean, K. Richard Young. Includes minutes, agendas, and discussion points. Materials date from 2006-2007.
Department of Teacher Education awards, 2007 February 7
Contains a scholarship recommendation for the Young Scholar Award to Kendra Hall-Kenyon and contains her vita. Materials are from 2007.
Department of Teacher Education course materials, 2004
Contains course level documentation (syllabi), elementary education, course identification, and instructor information, and other materials for teachers at college and elementary level. Materials are from 2004.
Department of Teacher Education executive committee minutes, 2005-2006
Contains materials related to the Department of Teacher Education executive committee including agendas, calendars, faculty lists, correspondence, elementary and secondary materials, and other materials. Materials date from 2005-2006.
Department of Teacher Education records
Contains minutes, awards, course documents, and other materials from the Department of Teacher Education. Records includes documentation of department administration, the Cluff lecture, and the curriculum. Materials date from between 2004 and 2007.
Department of Teacher Education records on Benjamin Cluff Jr. Lecture, 2005 September 15
Contains a program, How People Learn booklets, a biographical sketch of the keynote speaker, John Bransford, a booklet on How Students Learn, and other material related to the department's Cluff Lecture. Materials date from 2005.
- Archival Object 5
- Collection 1
- Education -- Study and teaching -- Utah -- Provo 5
- Colleges and Universities 4
- Education 4
- Minutes (Records) 3
- Letters 2
- Outlines 2
- Agendas 1
- Awards 1
- Benjamin Cluff Jr. lecture 1
- Calendars 1
- Clippings (Books, newspapers, etc.) 1
- Learning -- Social aspects 1
- Learning, Psychology of 1
- Pamphlets 1
- Programs 1
- Résumés (Employment) 1 ∧ less

domain: library


text:
Polygenic prediction of breast cancer: comparison of genetic predictors and implications for risk stratification
BMC Cancer volume 19, Article number: 557 (2019)
Published genetic risk scores for breast cancer (BC) so far have been based on a relatively small number of markers and are not necessarily using the full potential of large-scale Genome-Wide Association Studies. This study aimed to identify an efficient polygenic predictor for BC based on best available evidence and to assess its potential for personalized risk prediction and screening strategies.
Four different genetic risk scores (two already published and two newly developed) and their combinations (metaGRS) were compared in the subsets of two population-based biobank cohorts: the UK Biobank (UKBB, 3157 BC cases, 43,827 controls) and Estonian Biobank (EstBB, 317 prevalent and 308 incident BC cases in 32,557 women). In addition, correlations between different genetic risk scores and their associations with BC risk factors were studied in both cohorts.
The metaGRS that combines two genetic risk scores (metaGRS2 - based on 75 and 898 Single Nucleotide Polymorphisms, respectively) had the strongest association with prevalent BC status in both cohorts. One standard deviation difference in the metaGRS2 corresponded to an Odds Ratio = 1.6 (95% CI 1.54 to 1.66, p = 9.7*10− 135) in the UK Biobank and accounting for family history marginally attenuated the effect (Odds Ratio = 1.58, 95% CI 1.53 to 1.64, p = 7.8*10− 129). In the EstBB cohort, the hazard ratio of incident BC for the women in the top 5% of the metaGRS2 compared to women in the lowest 50% was 4.2 (95% CI 2.8 to 6.2, p = 8.1*10− 13). The different GRSs were only moderately correlated with each other and were associated with different known predictors of BC. The classification of genetic risk for the same individual varied considerably depending on the chosen GRS.
We have shown that metaGRS2, that combined on the effects of more than 900 SNPs, provided best predictive ability for breast cancer in two different population-based cohorts. The strength of the effect of metaGRS2 indicates that the GRS could potentially be used to develop more efficient strategies for breast cancer screening for genotyped women.
Breast cancer (BC) is the most frequent cancer among women in the world, being also the second leading cause of cancer death in women in more developed regions after lung cancer . As early diagnosis for BC could lead to successful treatment and good prognosis for recovery, it is important to develop efficient risk prediction algorithms that aid to identify high-risk individuals. Although many countries have implemented mammography screening programs, they are mostly applied to all women in certain age categories without any additional stratification by other risk factors. However, the benefits of such screening programs are often debated. Existing tools to assess BC risk [2,3,4] are often not systematically used in screening due to insufficient up-to-date risk factor’s information. Also, they only capture the heritable component either in the form of family history or using the information on rare genetic variants (BRCA1/2).
It has been estimated in twin studies that the heritability of breast cancer ranges from 20 to 30% . However, only 5–10% of BC cases have a strong inherited component identified in a form of rare genetic variants , indicating that in addition there should be a considerable polygenic component in the disease liability. This is also supported by the results of large genome-wide association studies (GWAS) – more than 100 genomic loci have been identified as being associated with BC in Europeans .
Based on the GWAS results, several efficient polygenic risk scores (GRS) have been developed for common complex diseases that in many cases could be used to improve the existing risk prediction algorithms [8,9,10,11]. It is natural to expect that a similar GRS for BC may aid risk prediction in clinical practice.
So far, several studies have combined the SNPs with established genome-wide significance in a GRS for BC. Sieh et al  used 86 SNPs and Mavaddat et al  77 SNPs to calculate a GRS, both showing a strong effect of the score in predicting future BC cases. Few studies have also demonstrated the incremental value of adding GRS to proposed BC prediction algorithms [14, 15]. Although several different GRSs have been proposed for BC risk prediction, no head-to-head comparison of the scores has been found in the literature. It has also not been assessed, whether the number of SNPs in the GRS could be increased. The latter was also problematic due to unavailability of summary statistics from large-scale GWASs.
In 2017, the large scale GWAS by Michailidou et al  released summary statistics for around 11.8 million genetic variants. Almost at the same time, UK Biobank released their GWAS results for BC for ~ 10.8 million SNPs. As evidence from studies on other common complex diseases have indicated that predictive ability of a GRS can be improved by adding the effects of a large number of independent SNPs in addition to the ones with established genome-wide significance, we intended to explore this approach using both summary files.
In the present analysis, the data of 32,557 female participants of the Estonian Biobank (EstBB)  has been used, with 317 prevalent and 308 incident cases of BC. Incident disease data was obtained from linkages with the Estonian Health Insurance Fund, Estonian Causes of Death Registry and Estonian Cancer Registry (latest update in December 2015).
We have also analyzed the data of 46,984 women (incl 3157 BC cases) of European ancestry from the UK Biobank  who passed the main quality control and were not included in the UKBB breast cancer GWAS .
General concept of genetic risk scores (GRS)
The general definition of a GRS was based on the assumption that the polygenic component of the trait (e.g. disease risk) can be approximated by a linear combination of k independent SNPs:
where βj is the weight of each SNP and Xij represents the number of risk alleles for j − th SNP (j = 1, … , k) for the i − th individual, (i = 1, … , n.). Typically the estimated (logistic) regression coefficients from a large-scale GWAS meta-analysis are used as weights βj.
Published versions of GRS can be divided to two main categories. We called a GRS multigenic, if the number of SNPs (k) is relatively small, containing only the SNPs with established genome-wide significance from a GWAS. A polygenic GRS contained a large number of SNPs (often k > 1000) and was either based on all available independent SNPs (with pairwise correlation not exceeding a pre-defined threshold) or the ones that satisfy some p-value threshold (often ≥0.05).
In the present paper, we computed two multigenic and two polygenic GRSs, whereas the polygenic GRSs were developed using the PRSice software .
Computation of multigenic and polygenic GRSs and analysis of their association with prevalent breast cancer
First we calculated two previously published multigenic GRSs for the EstBB data – both scores contained only those SNPs from the originally published versions that were available with acceptable imputation accuracy in the EstBB.
The score denoted by GRS70, based on Sieh et al (70 SNPs out of 86 were available).
The score GRS75, based on the 75 SNPs of the 77-SNP score by Mavaddat et al .
Next, polygenic GRSs were developed based on summary statistics of two different GWAS meta-analyses. First, two sets of independent SNPs were obtained so that: a) the SNPs with available summary statistics were genotyped or imputed with acceptable quality in the EstBB; b) the pairwise correlations between SNPs did not exceed a pre-specified threshold of r2 > 0.1 (more details on SNP selection provided in the Additional file 2). Subsequently, the selected SNPs were further filtered based on their p-value in the meta-analysis (using one of the pre-specified p-value thresholds). The corresponding effect estimates of the filtered subset were then used as weights to compose the GRSs. Altogether, we used 22 different p-value thresholds to compose 44 different versions of GRSs – 22 based on first meta-analysis and 22 based on the second one. To select the best predicting GRSs out of 44, age-adjusted logistic regression model comparing 317 prevalent BC cases and 2000 randomly chosen controls in the EstBB cohort was used and the scores with the smallest p-value for the GRS-phenotype association were selected (calculations about power to detect GRS-phenotype associations provided in Additional file 2). The resulting polygenic scores were:
The score GRSONCO, based on the summary statistics of the Breast Cancer Association Consortium meta-analysis of BC with 122,977 cases and 105,974 controls .
The score GRSUK, based on the summary statistics of the GWAS conducted on the UK Biobank data (comparing 7480 BC cases and 329,679 controls including both men and women ). The reported linear regression coefficients were transformed into corresponding log odds ratios, following the rules described by Lloyd-Jones et al , before using them as weights in the GRS.
Thereafter, Pearson coefficients of correlation between all GRSs (GRS70, GRS75, GRSONCO, GRSUK) were calculated. Then GRSs were combined into three different versions of metaGRS, following the ideas by Inouye et al : metaGRS4 as the weighted average of all four GRSs, metaGRS3 as the weighted average of three GRSs with the strongest association with incident BC and finally metaGRS2 based on top two predicting GRSs. To construct metaGRS, log (odds ratios) of GRSs from training set from logistic regression model were used as weights.
Finally, the UK biobank data was used to further compare previously mentioned 7 GRSs and to address the attenuation of GRS’ effect while accounting for family history of BC and to study associations between BC risk factors and GRSs. While modelling in UK biobank, age at recruitment and 15 principal components were included in the model. The entire workflow was visualized in the Fig. 1.
Analysis of the GRS effects on incident BC
All 7 GRSs were evaluated in the analysis of incident BC in 30,240 women from the EstBB cohort who did not have an existing BC diagnosis at recruitment and were not included in the case-control set used to select the best polygenic GRSs. Cox proportional hazard models were used to estimate the crude and adjusted Hazard Ratios (HR) corresponding to one standard deviation (SD) of the GRS. To assess the incremental value of GRSs when added to other known risk factors, the models were additionally adjusted for the absolute risk estimates from the NCI Breast Cancer assessment tool [2, 22], based on age, race (for all participants, it was set to “White”, because only individuals with European decent were included), age at menarche and age at first live birth of the participant. Other possible risk factors such as number of biopsies were set as unknown. Harrell’s c-statistic to characterize the discriminative ability of each GRS and their incremental value compared to NCI’s Breast Cancer assessment tool absolute risk estimates alone were computed. Hazard ratios for GRS top quintile and top 5% percentile compared to average, median and low GRS categories were reported. Cumulative incidence estimates were computed with Aalen-Johansen estimator to account for competing risk. While comparing different GRS groups with each other, age was used as timescale to properly account for left-truncation in the data. While computing HR for continuous GRSs and comparing Harrell’s c-statistics alone and together with NCI estimates, follow-up time was used as timescale, as age is already included in NCI estimates.
Finally, associations between GRSs and variables related to female’s reproductive health and BC risk factors were explored using linear, logistic or Cox regression models depending on the type of dependent variable in both EstBB and UKBB cohorts (more details in the Additional file 2).
GRSs association with prevalent breast cancer
Both GRS70 and GRS75 were significantly associated with prevalent BC status in the case-control subset of the EstBB cohort, with corresponding Odds Ratio (OR) estimates per one SD of the GRS being 1.27 (95% CI 1.13 to 1.45, p = 1.4*10− 4) and 1.38 (95% CI 1.22 to 1.57, p = 5.3*10− 7), respectively. Of all polygenic GRSs, the strongest association was observed for GRSONCO with p-value threshold p < 5* 10− 4 for SNP inclusion (898 SNPs). This resulted in OR = 1.44 (95% CI 1.27 to 1.64, p = 1*10− 8) per one SD of the GRS. The best version of GRSUK included 137 SNPs that satisfied inclusion threshold p < 5*10− 5 and resulted in OR = 1.34 (95% CI 1.18 to 1.52, p = 5.5*10− 6). Similar effect sizes for all four GRSs were observed in the UKBB cohort (Additional file 1: Table S2). Detailed results on GRS-outcome associations in EstBB with different p-value thresholds for SNP inclusion can be seen in Additional file 2: Figure S1.
Association of incident breast cancer and GRSs
Out of four studied GRSs, GRSUK had the weakest and GRS75 the strongest association with incident BC (Table 1) in the EstBB, both in terms of the p-value as well as the Harrell’s c-statistic. All metaGRSs had stronger association with incident BC than original scores alone. However, when GRSONCO and GRS75 are already combined into metaGRS2, no additional gain was seen from adding GRSUK and/or GRS70 to the score. Therefore, we chose metaGRS2 for further assessment of its properties. While a predictive model capturing the effect of the NCI risk estimates resulted in the Harrell’s c-statistic of 0.677, it was increased to 0.715 (by 3.8%) when also metaGRS2 was added to the model.
The score metaGRS2 and its potential for personalized breast cancer risk prediction
Women in the highest quartile of metaGRS2 distribution had 3.40 (95% CI 2.36 to 4.89) times higher hazard of developing BC than women in the lowest quartile. When the top quartile is further split into smaller percentiles (as seen on Fig. 2), a strong risk gradient was seen also within this quartile. Namely, women in the top 5% of the metaGRS2 distribution had a Hazard Ratio (HR) of 4.79 (95% CI 3.02 to 7.58) for incident BC compared to women in the lowest quartile, whereas HR = 4.20 (95% CI 2.84 to 6.23) for women in the top 5% compared to all women with metaGRS2 below the median. When the highest 5% percentile was compared with the rest of the cohort (women below the 95th percentile of metaGRS2), about three times higher hazard (HR = 2.73, 95% CI 1.92 to 3.90) was found. Compared to the women with metaGRS2 close to the median (belonging to the 40th to 60th percentile), the hazard of women in the top 5% of metaGRS2 was 2.7 (95% CI 1.77 to 4.18) times higher and the hazard of those with metaGRS2 below 40th percentile was almost 2 times lower (HR = 0.54, 95% CI 0.37 to 0.79) to develop BC.
As seen from Fig. 2, the cumulative BC incidence by the age of 70 was estimated to be 12% (95% CI 7.7 to 16.3%) for women in the top 5% percentile of metaGRS2, 8.3% (95% CI 5.6 to 11.0%) for those between 85 and 95% percentiles and 7.4% (95% CI 4.85 to 10.0%) for the women in 75–85% percentiles. Cumulative BC incidence in the third, second and first quartile of the metaGRS2 distribution was estimated to be 5.8% (95% CI 4.4 to 7.3%), 3.6% (95% CI 2.4 to 4.8%) and 2.4% (95% CI 1.4 to 3.3%), respectively. No significant difference in BC hazard was seen between the two lowest quartiles (p = 0.26), with both of them having considerably lower incidence level than the cohort average (overall cumulative BC incidence estimated as 5.1% by the age of 70, 95% CI 4.5 to 5.8%).
Correlation of GRSs
The correlations between seven scores varied between 0.3 to 1 (see Additional file 2: Figure S2). After dividing individuals into 2 categories (“non-high” – GRS < 95th percent and “high” – GRS in top 5%) based on three GRSs (GRSUK, GRSONCO or GRS75), 87.7% (28547) of women were assigned to non-high category with all three scores. However, 12.4% (4010) of women belonged to high category with at least one GRS. 0.33% (109) of women belonged to top 5% with all three scores compared to ~ 10% (3240) of the women, who belonged into high category only with one score (Fig. 3).
Associations of GRSs and other genetic and non-genetic predictors of breast cancer
Both family history as well as GRSs were strongly associated with BC status in UKBB, while the effects of GRSs were attenuated by less than 1% while adjusting for family history (Additional file 1: Table S2). The effect of family history was attenuated by 2.9–8.4%, depending on which GRS the model was adjusted for. For instance, the OR corresponding to the family history changed from 1.87 to 1.82 (corresponding to 2.9% change) while adjusting for the GRSUK and to 1.71 (corresponding to 8.4% change) while adjusting for the metaGRS2. Known BC risk factors were only weakly associated with GRSs in both UKBB and EstBB cohorts (Additional file 1: Table S3-S4). BMI and waist circumference were negatively associated with GRSUK in both EstBB and UKBB, the association in EstBB was stronger for women under 50 years of age. Smoking status was positively associated with all GRSs except GRSUK only in EstBB data. Age at menopause was associated with some GRSs in both cohorts but the effects were in opposite direction. No GRS showed association with any other type of cancer or overall mortality.
We demonstrated that a metaGRS that combines a multigenic and a polygenic GRS for breast cancer - metaGRS2 - performed better than using either one of the previously published multigenic GRSs and also better than the best polygenic GRS alone. While in average about 5% of women in the EstBB cohort (as well as in the Estonian population) have been diagnosed with BC by the age of 70, women in the highest five percentiles of the metaGRS2 distribution reach the same cumulative risk level (5, 95% CI 2.1 to 7.8%) by the age of 49, thus more than 20 years earlier. It is also notable that women with metaGRS2 level below median reach such risk level (4.6, 95% CI 3.6 to 5.6%) only by age of 79, thus almost 10 years later. These findings suggest that the polygenic risk estimate based on metaGRS2 could be an efficient tool for risk stratification in clinical practice, for targeted screening and prevention purposes.
Given that the potential benefits of non-selective BC screening within certain age categories (compared to potential harm from over diagnosis) have been under serious discussion in the medical community , personalized approaches based on individual risk levels deserve further assessment. Ideally, those should integrate available information from clinical risk factors and also genetic information. The latter could include both moderate- and high-penetrance germline mutation testing, as well as polygenic risk scores. That approach is also supported by our findings, where considerable increase in c-statistics were observed while combining polygenic risk scores and NCI estimates together.
However, while incorporating a GRS in clinical BC prediction, one should keep in mind that a GRS represents a mixture of different pathways, but is still not likely to capture the heritable component completely. As our findings indicated that a GRS and family history have independent predictive effects on BC risk, accounting for individual’s genetic information and family history (indicating either the mother has suffered from breast cancer or not or the status is unknown) simultaneously seemed to result in the better risk estimation than using only one of these predictors alone. However, more research is needed to assess the usefulness of combining our proposed metaGRS2 with full pedigree-based family history data.
As depending on a GWAS that is used as a basis, different (and not necessarily highly correlated) GRSs can be produced, it can be expected that those GRSs might emphasize the effects of different biological pathways. This hypothesis seems plausible in the light of several associations found between different GRSs and BC risk factors. Expectedly, GRSs including only a small number of significant SNPs (like GRS75 and GRS70) were highly correlated and if we could have included all original 86 SNPs instead of 70, correlation between GRS86 and GRS75 would have likely remained similar or decreased a little, as excluded SNPs from the original 86 SNPs were rather rare.
The fact that a metaGRS performed better than alternatives, suggests that even though the multigenic GRS75 including only genome-wide significant SNPs was already a good predictor for BC, other SNPs included in the polygenic GRSONCO - but not in the GRS75 - have some additional predictive power. Most likely, not all SNPs included in the GRSONCO are truly associated with BC, however, as they have some predictive power, possibly also through being associated with some of the risk factors of BC, one should not completely ignore them while building an optimal GRS.
It remains an open question whether it is always the best practice to use metaGRS instead of several different genetic risk scores – if one can pinpoint biological mechanisms behind different scores, more optimal preventive strategies could be chosen. Still, until we are unable to convincingly link different GRSs with specific preventive measures, targeted prevention should be based on a GRS with the best possible overall predictive ability, such as the metaGRS2 proposed here.
One should also keep in mind that besides GRS there are genetic mutations such as BRCA1/2 known to be associated with very high familiar BC risk. Therefore, in practice, any genomic risk stratification procedure should also include search for high- and moderate-risk genetic variants, if possible. In the high-risk mutation carriers, the clinical management could be based on the specific genetic (mendelian) variants, or if deemed useful in the future, a combination of mendelian variants and GRS levels, but it definitely needs further studies.
In summary, our results showed that an efficient polygenic risk estimate enables to identify strata with more than four-fold differences in BC incidence. This definitely calls for the development of personalized screening and prevention strategies that incorporate the GRS information, having the potential to considerably increase the benefits of nation-wide screening programs and reduce the existing controversies on their efficacy. However, one should be aware of the fact that a GRS is still a proxy of a true genetic risk and it is not uniquely defined – as more research accumulates, more efficient polygenic predictors could be developed that may re-categorize some previously stratified individuals into high or low risk groups. In addition, a GRS should ideally be combined with information on other genetic and non-genetic risk factors for best possible accuracy in risk assessment.
Availability of data and materials
We do not have ethical approval to share individual level genotype and phenotype data for Estonian Biobank. The data from UK Biobank were used under license for the current study, and so are not publicly available. Researchers interested in Estonian Biobank can request the access here: https://www.geenivaramu.ee/en/access-biobank and access to UK Biobank can be requested here http://www.ukbiobank.ac.uk/resources/.
Genetic Risk Score
Genome-Wide Association Study
combination of several genetic risk scores number in subscript indicates the number of original GRSs included
National Cancer Institute Breast Cancer
Single Nucleotide Polymorphism
International Agency for Research on Cancer. GLOBOCAN 2012:Estimated Cancer Incidence, Mortality and Prevalence Worldwide in 2012. http://globocan.iarc.fr/Pages/fact_sheets_cancer.aspx. Accessed 9 May 2018.
National Cancer Institute. Breast Cancer Risk Assessment Tool. https://www.cancer.gov/bcrisktool/Default.aspx. Published 2011. Accessed 2 May 2018.
Hippisley-Cox J, Coupland C. Development and validation of risk prediction algorithms to estimate future risk of common cancers in men and women: prospective cohort study. BMJ Open. 2015;5(3):e007825. https://doi.org/10.1136/bmjopen-2015-007825.
Lee AJ, Cunningham AP, Kuchenbaecker KB, Mavaddat N, Easton DF, Antoniou AC. BOADICEA breast cancer risk prediction model: updates to cancer incidences, tumour pathology and web interface. Br J Cancer. 2014;110(2):535–45. https://doi.org/10.1038/bjc.2013.730.
Moller S, Mucci LA, Harris JR, et al. The heritability of breast Cancer among women in the Nordic twin study of Cancer. Cancer Epidemiol Biomark Prev. 2016;25(1):145–50. https://doi.org/10.1158/1055-9965.EPI-15-0913.
Apostolou P, Fostira F. Hereditary breast cancer: the era of new susceptibility genes. Biomed Res Int. 2013;2013:747318. https://doi.org/10.1155/2013/747318.
Michailidou K, Lindström S, Dennis J, et al. Association analysis identifies 65 new breast cancer risk loci. Nature. 2017;551(7678):92–4. https://doi.org/10.1038/nature24284.
Läll K, Mägi R, Morris A, Metspalu A, Fischer K. Personalized risk prediction for type 2 diabetes: the potential of genetic risk scores. Genet Med. 2017;19(3):322–9. https://doi.org/10.1038/gim.2016.103.
Abraham G, Havulinna AS, Bhalala OG, et al. Genomic prediction of coronary heart disease. Eur Heart J. 2016;37(43):3267–78. https://doi.org/10.1093/eurheartj/ehw450.
Power RA, Steinberg S, Bjornsdottir G, et al. Polygenic risk scores for schizophrenia and bipolar disorder predict creativity. Nat Neurosci. 2015;18(7):953–5. https://doi.org/10.1038/nn.4040.
Krapohl E, Patel H, Newhouse S, et al. Multi-polygenic score approach to trait prediction. Mol Psychiatry August 2017. doi:https://doi.org/10.1038/mp.2017.163.
Sieh W, Rothstein JH, McGuire V, Whittemore AS. The role of genome sequencing in personalized breast Cancer prevention. Cancer Epidemiol Biomark Prev. 2014;23(11):2322–7. https://doi.org/10.1158/1055-9965.EPI-14-0559.
Mavaddat N, Pharoah PDP, Michailidou K, et al. Prediction of breast cancer risk based on profiling with common genetic variants. J Natl Cancer Inst. 2015;107(5). https://doi.org/10.1093/jnci/djv036.
Maas P, Barrdahl M, Joshi AD, et al. Breast Cancer risk from modifiable and nonmodifiable risk factors among white women in the United States. JAMA Oncol. 2016;2(10):1295. https://doi.org/10.1001/jamaoncol.2016.1025.
Li H, Feng B, Miron A, et al. Breast cancer risk prediction using a polygenic risk score in the familial setting: a prospective study from the breast Cancer family registry and kConFab. Genet Med. 2017;19(1):30–5. https://doi.org/10.1038/gim.2016.43.
Leitsalu L, Haller T, Esko T, et al. Cohort profile: Estonian biobank of the Estonian genome center, University of Tartu. Int J Epidemiol February 2014:dyt268-. doi:https://doi.org/10.1093/ije/dyt268.
Sudlow C, Gallacher J, Allen N, et al. UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age. PLoS Med. 2015;12(3):e1001779. https://doi.org/10.1371/journal.pmed.1001779.
Ben Neale Lab. Rapid GWAS of thousands of phenotypes for 337,000 samples in the UK Biobank — Neale lab. http://www.nealelab.is/blog/2017/7/19/rapid-gwas-of-thousands-of-phenotypes-for-337000-samples-in-the-uk-biobank. Published 2017. Accessed 2 May 2018.
Euesden J, Lewis CM, O’Reilly PF. PRSice: polygenic risk score software. Bioinformatics. 2015;31(9):1466–8. https://doi.org/10.1093/bioinformatics/btu848.
Lloyd-Jones LR, Robinson MR, Yang J, Visscher PM. Transformation of summary statistics from linear mixed model association on all-or-none traits to odds ratio. Genetics. 2018;208(4):1397–408. https://doi.org/10.1534/genetics.117.300360.
Inouye M, Abraham G, Nelson CP, et al. Genomic risk prediction of coronary artery disease in nearly 500,000 adults: implications for early screening and primary prevention. bioRxiv. January 2018:250712. doi:https://doi.org/10.1101/250712.
Zhang F. BCRA: breast Cancer risk assessment. 2018. https://cran.r-project.org/package=BCRA.
Autier P, Boniol M, Koechlin A, Pizot C, Boniol M. Effectiveness of and overdiagnosis from mammography screening in the Netherlands: population based study. BMJ. 2017;359:j5224. https://doi.org/10.1136/BMJ.J5224.
This research has been conducted using the UK Biobank Resource under Application Number 17085.
EGCUT was supported by Estonian Research Council [IUT20–60, IUT24–6, PUT1660 to T. E and PUT1665 to K.F.; European Union Horizon 2020 ; European Union through the European Regional Development Fund [2014–2020.4.01.15–0012 GENTRANSMED] and National Programme for Addressing Socio-Economic Challenges through R&D (RITA). The funding bodies had no influence on the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.
Ethics approval and consent to participate
EstBB: All human research was approved by the Research Ethics Committee of the University of Tartu (approval 234/T-12), and conducted according to the Declaration of Helsinki. All participants provided written informed consent to participate in the Estonian Biobank.
UKBB: The UK Biobank study was approved by the North West Multi-Centre Research Ethics Committee (reference for UK Biobank is 16/NW/0274). All participants provided written informed consent to participate in the UK Biobank study.
Consent for publication
The authors declare that they have no competing interests.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Table S1. Cohort characteristics of UK Biobank and Estonian Biobank. Table S2. Associations of breast cancer and standardized GRSs in the UK Biobank (with and without adjustment of family history) and in Estonian Biobank without family history. Table S3. Associations between GRSs and risk factors of breast cancer in Estonian Biobank. Table S4. Associations between GRSs and risk factors of breast cancer in UK Biobank. (XLSX 30 kb)
Figure S1. Associations of GRSs with prevalent breast cancer in EstBB data. Figure S2. Correlations between different genetic risk scores (GRSs). Figure S3. Power to detect an association between GRS and breast cancer status given the sample size of the case-control and prevalence of the disease. (DOCX 128 kb)
About this article
Cite this article
Läll, K., Lepamets, M., Palover, M. et al. Polygenic prediction of breast cancer: comparison of genetic predictors and implications for risk stratification. BMC Cancer 19, 557 (2019). https://doi.org/10.1186/s12885-019-5783-1
- Polygenic risk score
- Genetic predisposition to disease
- Breast cancer
- Risk stratification
- Personalized medicine

domain: literature


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As all garden beds are either fully planted or overrun by weeds and grass (the majority), I resorted to planting in this trough. The eggplants are still tiny seedlings, so let's hope they'll start growing soon and provide us with some fruit this season.
The varieties are Black Beauty, Listada di Gandia, Thai Green, Rosita and Bianca Oval.
The theory behind the trough is also that I might be able to protect the plants in there over winter (some kind of mobile greenhouse thingie). This way they'd come alive again in Spring and this would (theoretically) give them quite a head start.


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Think dogs don’t belong in hospitals? Think again. According to a growing body of anecdotal evidence collected by the Royal College of Nursing (RCN), animal visitors can play a vital role in promoting recovery, as reported by BBC.com. Here’s a closer look at the findings, along with a research project underway aimed at sharing best practices for “pet protocol” regarding animals and healthcare environments.
Therapy Animals and Beyond
“In a recent RCN survey of 750 nursing staff, 82% said animals could help patients be more physically active and 60% said they believed animals improved physical recovery,” reveals BBC.com. From therapy dogs helping to calm young cancer patients during life-saving procedures to a pet donkey which helped its owner recover balance and mobility following a brain injury, the potential of animals to help patients get better is profound, insist advocates.
And yet, despite the abundance of stories like these, pets are not allowed on most hospital wards, clinics, and hospices due to concerns about the spread of infections and other “myths” about the dangers of animals.
Collecting Evidence Toward Raised Awareness
In an effort to improve understanding of the benefits and challenges of dogs and other animals in hospitals, researchers at Southampton Children's Hospital are assembling a set of simple guidelines which could be adopted by healthcare facilities. These include booking specific appointments at specific times to prevent animals from roaming from patient to patient; ensuring that all vaccinations are current, and even cleaning paws with hospital grade wipes.
And while the conversation is largely focused on what pets can do for people, experts say people may also play an equally vital role for their pets. Explains dog handler Lyndsey Uglow, “To really find out the true value of therapy visits and to firmly establish it as beneficial in healthcare, we have to strengthen the evidence behind it….Our starting point is the impact of dogs with children but the same principles could, over time, be mirrored into other departments and into veterinary healthcare - for example, if animals recover better in a veterinary hospital or with their human family and if family visits aid animal recovery."
The UK’s medical schools must double the number of spaces available in order to stay ahead of a rising physician shortage and healthcare crisis, say...
Two University of Cape Town medical students developed an app to improve communication with the deaf community. Learn more about their exciting work.
A recent report from the UK’s Institute for Fiscal Studies (IFS) reveals new insights into which degrees offer the most significant financial return...


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Jeeves & Wooster By Jake Phipps
Jeeves & Wooster Overview
Jeeves & Wooster are a blend of Great British tradition and modern technology, hand-made wool felt hats are lined with an aluminium inner shell to create quirky pendant lights. They are named after P.G. Wodehouse’s two iconic characters. Wooster, the jovial but empty-headed young gentleman, and Jeeves, his improbably well-informed and talented valet. Wooster is therefore the top hat, symbol of aristocracy and well to do society and Jeeves the practical well rounded bowler. They are a pair of fittings a that work well on their own, as a duo or mix well into bigger groups.
Specification + Downloads
Material: Wool felt bowler or top hat with anodised aluminium lining
Dimensions and Product Codes:
JEEVES: 13cm H x 25cm W x 30cm L
Colour: Black with gold anodized interior
UK/EU: PJ029102 US: PJ029302
WOOSTER: 14cm H x 27cm W x 32cm L
Colour: Black with silver anodized interior
UK/EU: PW029102 US: PW029302
Light source: UK/EU G9 Max 25W, USA G9 Max 5W(not included)
Recommended Bulb: Any G9 LED Bulb up to 500 lumen output, dimmable. Temperature 2200 – 2700K.
Ceiling Rose: Black Hemisphere
Cable: 2.4m, Black braided cable

domain: artistic


ASB Bank and advertising agency Saatchi & Saatchi from New Zealand have released this hilarious video spot recently. The commercial is rather bizarre, we have to admit. However, the weird things are often the most exciting.
Domestos and Droga5 – the Sydney’s creative agency – launched a new really crazy toilet cleaner commercial. The creatives took a totally different approach to Domestos. The advertisement begins as a documentary, telling about the bodybuilder. His wife is talking about his eating habits and we can see him getting up early, training and eating.


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The Christmas beetle is hand drawn and printed by hand in gold ink onto off-white linen.
size: 45cm x 45cm (approx 17.5" x 17.5")
fabric: 100% linen
Care: Cold machine wash. Line dry in shade. Hot, dry iron over a cloth to prevent scorching.
Do NOT bleach, soak, tumble dry or dryclean

domain: design


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We are a little conservative in our mind sets when it comes to healthy eating. We automatically assume that if its good for your body, its gonna taste bad. However, that does not necessarily have to be the case and Calorize is all set to prove that point. They have a good variety of options on their menu but are mostly popular for their subs. If you are turning to a healthy chapter in your life, it’ll be a great place for you to get a tasty fix at the amount of calories that suits your need.
Calorize is located on the first floor of the Good Earth City Centre toward the front section. I made my way to this outlet with my sister for a healthy meal option. As we entered, we were welcomed by a quirky colourful cafe with a wooden theme. The use of elements is just perfect and I love the little pop of colours against the earth tone background. They have a large wooden wall piece with fun health quotes on it. It is spacious with comfortable seating and the play list keeps your foot tapping.
The concept behind the outlet is to get you delicious food that satisfies cravings yet helps you keep a check on your calories. They bake their breads in house, make their own dressings and do not believe in using preservatives and go for fresh selection of vegetables. It certainly puts my mind at rest when I get to get fresh food rather than day old preparations. So the good thing here is that they count the calorie of every ingredient that goes into making the dish from the veggies, meat to oil or herbs added and give you your total count.
Get Set Gobble:
~ Drinks – We started off with our HEALTH MODE ON so I went for the Grape and Pineapple health booster which was a blend of fresh pineapple and grape juice with chunks of the fruit as well. It tasted so good! My sister went for one of the Fantastic 5 drinks on the menu and choose Iron. This had a combination of watermelon, pineapple, orange, spinach and cayenne. It had a tangy taste with a very slight undertone of chilli. Loved it too! This came in a small glass bottle with a label on it. I found the presentation really nice. MUST TRY one of the 5 drinks from the menu.
Well we sipped on these and went on with our meal. But at the end we kind of gave into temptation a little and went in for shakes. So yes, we kind of saved up on calories from our meal and spent them on these rich shakes that I would like to say were like desserts. I had the Chocolate fudge brownie from the Spoiler Shake section…what an apt name 😉 I loved this more than my sister’s for the simple reason that it had little chunks of brownie in the shake that added a little bite to it. My sister had the Dark and White choco blast. Both the shakes were super rich and thick and had a good blend of chocolate. HIGHLY RECOMMENDED if you are willing to give your calorie counting a little skip.
~ Chicken keema masala sub – They have an android tablet hanging on the table. You can go ahead and place your order though it or choose to do it via pen and paper. All options of fillings of meat and veggies, sauces, dressings, etc. is mentioned for you to choose from. The paper bag serves not only as your order form, but as a take away bag or as surface to a feedback on. If it’s too much effort for you to figure out the nitty gritties of your sub, go ahead and simply order some ready made combinations off the menu. I found the android version quite convenient. It’s super quick and easy to make your choices and an added advantage is that the app gives you suggestions along the way to create the best combination.
They have something called the Shaved bread sub. So if you are someone like my mom who doesn’t like eating breads in general, this is a good option for you. What they do is they remove the center part of the bread and just give you the crunchy outer layer with more stuffing, hence the name shaved. You can also go in for an even healthier option and choose to convert it into a lettuce wrap that eliminates the bread all together. I personally looooooove all things doughy so no way was I skipping out on the bread in my sub. 😛
Here’s the selections we made: What would you like to have today? Sub sandwich (6 inch) >> Choose your genre – Non veg – Chicken keema masala >> Please select your bread – Herb>> How do you want your bread – Toasted >> Select your toppings – Cheese – Bocconcini (lowest calorie) – Spreads/Sauces – Masala chutney (as the app suggested) – Dressings – Thousand Island (again app suggestion) – Veggies – Lettuce, caramelized onions, bell peppers – Oil + spices – Garlic powder, salt, pepper >> Special instruction – less spicy please! >> Order summary – Pay >> Thank you for ordering with us – 451kcal. It was actually interesting going through all the options and discussing what would make the best sub for us and can I tell you, we were elated with the outcome..it was simply brilliant! The balance of the creamy dressing and spicy meat was spot on. MUST ORDER
~ NCYC pizza – A very attractive item on the menu is their No Cheese Yet Cheesy pizza…doesn’t the name make you curious as to what it is?? So basically it is a whole wheat base with toppings of veggies and BBQ chicken (they have vegetarian variations as well) along with a topping that this very similar to cheese in terms of look and taste but is not really cheese. I found it quite intriguing and poked them a bit more to figure out what this really is. Well, they didn’t give away too much and said it has a milk and yoghurt base and a secret binder that gives it it’s perfect texture. Go try it for yourself! I am from the school of thought that I want to enjoy things in life but don’t want too much burden of them having a fattening effect on my body, ergo, I think like all girls. 😛 I’m glad I have found and option that does just that. This is perfect for those days when you have pizza cravings but only now you have a healthy option to satisfy yourself.
Also, did you know that this entire pizza has the same amount of calories as one slice of pepperoni pizza. Doesn’t mathematics in food make you feel good! 😀
~ Honey mustard chicken meal – Their meals come with a portion of brown rice (or 4 pieces of brown bread), choice of sides like grilled veggies/ baked french fries/ mashed potatoes and choice of dips like hot pepper/ marinara/ white sauce/ butter garlic. The chicken breast had a honey mustard marinade and came with an orange mustard dip. The dip was the most exciting part of the meal. If you have eaten brown rice you know that it isn’t the tastiest option but a much healthier alternative to white rice. I poured oodles of the dip on the rice and ate it with the chicken. Quite liked it! DO TRY
~ Cookies – We ended the meal with the chocolate shakes I mentioned above and cookies. I ordered the oatmeal raisin and orange fiber cookie. I think the orange one was our favourite. Simply loved the cute little packing it came in and also the flavours. DO TRY
Calorie conscious healthy meals. Healthy = tasty food. Fun music. Add your feedback on their wall called ‘Sub ka review’…clever naming :-). Freshly baked breads and in-house sauces. They are working on adding new dishes on their menu and also a delivery system for it.

domain: food


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A conventional lottery company in Ho Chi Minh City has reported a healthy performance in 2017, despite aggressive competition from an American-style computerized rival that offers significantly bigger prizes.
The Ho Chi Minh City Lottery Company saw its pre-tax profit surpass the VND1 trillion (US$43.65 million) mark for the first time last year, according to the company’s audited finance report.
The company, Vietnam’s largest traditional lottery firm, raked in VND6,600 billion ($290.4 million) from sales and services in 2017, a five-percent rise from 2016 and exceeding the full-year target by ten percent.
The firm’s pre-tax profit topped VND1,040 billion ($45.76 million), overshooting its target by 35 percent, whereas its post-tax profit stood at VND832 billion ($36.6 million).
General director Do Quang Vinh attributed the healthy business results to the company’s successful efforts to increase revenue and cut costs.
“This result is no surprise to [us] as it was well anticipated in our business plan,” Vinh said.
Traditional lottery companies in other provinces have also experienced a good year with high growth in revenue, Vinh added.
“This proves that traditional lottery still hasn’t lost its appeal to customers,” he concluded.
But it was also Vinh who admitted in December 2016 that the introduction of computerized lottery ‘Mega 6/45’ in July that year by the state-run Vietnam Computerized Lottery (Vietlott) would threaten traditional lottery companies in the country.
According to Mega 6/45 rules, players can make a combination of six numbers from 01 to 45, then wait for the random selection of a jackpot combination which is made every Wednesday, Friday, and Sunday.
The jackpot, starting at VND12 billion ($528,000), rolls over each week until there is a winner.
Players who have the ticket matching the draw will receive a Mega 6/45 jackpot prize and those with three, four, and five numbers matching the jackpot combination will be awarded far lower prizes.
This is much more attractive than the conventional lottery, where people can only buy tickets with preset numbers and the biggest cash prize is only VND2 billion ($87,300), excluding a ten-percent tax.
Despite this, Vietlott only reported a net profit of VND217 billion ($9.55 million) in 2017, too small in comparison with the business results of some traditional lottery companies in southern cities and provinces, including Ho Chi Minh City, Tien Giang, Tay Ninh and Vinh Long.
Vietlott managed to sell a whopping 1.6 billion tickets, raking in VND1,600 billion ($70.4 million), from its launch to the end of 2016.


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| Composer:|| Foster, Stephen Collins 1826-1864|
|Lyrics:||Oh! Lilly dear, it grieves me (first line of text)|
Farewell forever to old Tennessee (first line of chorus)
|Description:||Farewell my Lilly dear : a plantation melody / as sung by Christy's Minstrels ; written & composed by S.C.F.|
For voice and piano, with duet refrain.
Copyright statement is repeated on p. 3.
Verses 2-4 printed as text on p. 5.
First line of text: Oh! Lilly dear, it grieves me.
First line of chorus: Farewell forever to old Tennessee.
Foster Hall Collection cutter no.: 141.2
|Format:||1 score (, 3-5,  p.) ; 35 cm.|
|Subjects:||Popular music--United States--To 1901|
African Americans--Songs and music
Love songs--United States
Slavery--United States--Songs and music
Vocal duets with piano
|Copyright:||Permissions/Copyright Statement for Sheet Music|
|OCLC Record ID:||23291600|


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Considering that a there are actually a bunch of people along with a typical rose tattoo design, there are actually likewise an improving volume of folks that desire rose tattoo designs however additionally wish to show from their individuality and acquire a various layout to what everybody else has.
Find affordable high end tattoo designs.
Sparrows are likewise a popular tattoo layout, especially amongst ladies as well as you will on a regular basis see them functioned in to the very same tattoo design as blooms or roses.
Heart designs can represent an individual's affection for somebody else, a person's affection permanently as well as humanity, or maybe a person's expect locating passion.
Tattoo design develops derived on this concept may reveal the rose in total bloom or even as a weed that will blossom, and even as a bunch of roses.
Helped along through the recognition from the Nautical Star, this is a tattoo style that is considerably well-known among popular as well as young body craft aficionados which take pleasure in listening back to the origins from tattooing.
While traditionally individuals would certainly link all the tattoo designs on their arms in to even more from a sleeve design, that is actually becoming progressively popular in order to get bunches of smaller sized concepts up your upper arms that are not always connected through anything.
The picked flowers should have emblematic interpretations and also if you truly desire one thing like that can select a lotus, rose, sunflower or a proverb tattoo style.
When a person close to them has actually perished, that is actually certainly not rare for males to pick an Angel tattoo layout.
You could additionally tattoo the heart beat of a relatived to present all of them that your lives will certainly always be actually connected and your passion will last for good.
This is actually much better to pick a initial and also distinct design in comparison to a mass market style - "flash" is actually made by superb musicians then sold to design musicians around the nation and around the world.
Get the best tattoo ideas.
Tattoos may seem truly amazing, offered a bunch of thought has actually entered choosing your layout, and also based precisely on the understanding that this is a long-lasting marking on your body system.
Angel Tattoos for Girls as well as Angel Tattoos for Females are a well-known selection for the fairer sex as Angels might be spokened to characterize elegance as well as grace.
Support tattoo designs are actually often associated along with the sturdy arms of sailors; however, not all individuals featuring these tattoos reside a quality of life mixed-up.
Whether you select your tattoo design motivation coming from a best 10 checklist or even go for a custom made piece, you can make your design a lot more relevant through conveying your distinct individualism within the physical body from the tattoo.
Occasionally much less is more along with designs, and also you just require to possess a design similar to this to have that different as well as lovely look that a bunch of individuals as well as girls are going with in today times.
Standard designs are actually typically detailed in black and afterwards filled out along with black shading or various other shades combineded with black ink.
Diamonds are actually one more well-liked tattoo layout and also our company adore exactly how comprehensive this is.
And our company're influenced by them too, making use of design font styles and also or browsing through other uplifting design styles.
Angel designs that act as remembrances are actually a number of the best popular concepts opted for by males particularly because they represent a personal they adored as opposed to some sort of mythical being actually or even tip.
Think me, there are actually great deals from design styles within this planet, as well as you should find quickly one perfect tattoo design for you.
Helping you get your hands on high quality tat designs in the following areas: 06255


Rugged Marine Panel PC for Rapidly Changing Climate and Extreme Weather Conditions of the Ocean.
For maritime industry, safety and reliability are always the upmost concern. Therefore, rugged, durable and long-term operation ability are required for marine facilities to overcome the extreme environment.
On the ocean, vessels will be facing horrible climate, environment and situations such as humidity, water drops, extreme temperature changes and intense shock & vibration. APLEX ViKING series is the fanless, true flat bezel designed marine panel PC with marine certificate and various features. It can endure harsh environment while protecting equipment from damage and can highly prevent malfunction situation.
In the middle of the ocean, lighting conditions may change massively during daytime and nighttime, therefore lighting control is essential for facilities on vessel. ViKING supports brightness from 0% to 100%, AR coating, optical bonding and three lighting modes for day, dusk and night to provide the best experience of reading information.
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Along with all the features that a marine facility requires, ViKING supports a stable and secure operation for verified functions, including navigation, surveillance, monitoring, data collection, data transmission and ship automation. Equipped with IEC 60945 maritime standard, makes it i perfect for marine applications, like control room and engine room.
High performance and reliable marine panel PC


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Reviewed by Christopher T. (age 12)
Many people would probably not like the idea of skipping Christmas. I, on the other hand would like to try it. Think about it this way???? you wouldn?t have to spend money on gifts, or you wouldn?t have to go to crowded malls. I would also like to take a cruise (who doesn?t?). One of the characters changed in the first few chapters. It was Nora, at first she did not like the idea of ?skipping Christmas? but later on she finally decided that it would be ok to just do it once.
I would recommend this because it is very enjoyable and fun to read (even if it isn?t Christmas time). I think you have to be a little bit advanced in reading if you want to read this book. I was attracted to this book because of its title maybe you will too. The characters are also very interesting such as Luther, he is usually grumpy but can be happy at times. Luther reminds me of an old man who is always complaining about things that aren?t a big deal. So I would pretty much recommend this book to anyone who can read!


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Artist and pattern maker Camille Walala has collaborated with fashion brand Armani on a campaign for its New Pop accessories collection.
Camille’s recognisable vivid gridded patterns are built as 3D sets for a series of still product shots and animated for a short film, featuring Armani accessories amidst mind-bending op art visuals. Using primary colours and crisp blocks of colour, the sets have a hyperreal aesthetic that could be mistaken for computerised renders, but the IRL objects give the game away.
The sets were designed by Camille for Armani’s AW16 season with direction by Paul Plowman, 3D work by Gary Smith, music by Malcolm Goldie and production by Big Active.
- Mikey Please takes us behind the scenes, and the backlash, of the Bake Off trailer
- From New York to Springfield, it's Best of the Web
- Taschen releases two volumes of National Geographic’s best photographs from the past 125 years
- Simon Landrein takes Dan Croll down the rabbit hole in his animated video for Tokyo
- Thomas Duffield on photographing his dad’s hidden heroin addiction
- Parker Day's lurid colours and grotesque characters elevate identity and fantasy (NSFW)
- Hate the iPhone X notch? There’s an app for that
- Lisa Simpson’s bookshelf: from the curator of Instagram’s Simpsons Library
- Biplab Hazra’s photo of elephants being attacked by mob wins Sanctuary prize
- Michael Bierut: 13 ways of looking at a typeface
- Uncle Ginger uses hypnotic shapes to animate the facts and feelings of bipolar disorder
- Michel Gondry’s John Lewis Christmas advert – Moz the Monster – is unveiled


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Publications in our database are reports and resource materials produced within the Department of Child and Family Studies, as well as recent journal articles authored by CFS faculty. To view a more thorough listing of recent books, book chapters and articles written or edited by CFS faculty, view our Impact Reports or individual faculty vitas. You may also view the publications by topic on the right of this page.
Viewing 211 to 220 of 314
- Community-based Theories of Change: Overview of Findings (2006)
- Discusses results to date of the Community-based Theories of Change study. Four characteristics from this cross-site cross-phase study are also discussed: identity, integration, initiative, and innovation. The study examines organizational structures and processes that human service organizations believe allow them to carry out their mission and goals and to sustain this effort over time.
- Educating Students with Emotional Disturbances: A National Perspective on Programs and Services (2006)
- This article presents results of a study of students with emotional disturbances (ED) and their experiences at the elementary, middle, and high school grade levels.
- School-Based Mental Health: An Empirical Guide for Decision-Makers (2006)
- The "Yellow Book" provides a discussion of barriers to school-based services with the intention of improving service effectiveness and capacity.
- Financing Structures and Strategies to Support Effective Systems of Care: RTC Study 3 Products (2006)
- This study was the first to thoroughly investigate cross-agency financing structures and strategies, and provides important information about finance policies that can assist communities across the country.
- Recommended Practices: Being an Evidence-Based Practitioner (2006)
- This fact sheet describes what evidence-based practitioners do, notes some of the challenges that affect the implementation of evidence-based practices, and offers advice for addressing those challenges.
- Examining the Impact of Policy on Collaboration in Systems of Care. (2006)
- This paper reports on the methods and outcomes of a two-phase study designed to determine the relationship between the mechanisms that have been used to establish systems of care and their resulting levels of collaboration.
- Findings: Examining the Impact of Policy on Collaboration in Systems of Care (2006)
- This article discusses how policy implementation affects collaboration at the state and community levels. Collaboration, in turn, contributes to effective systems of care.
- Building the Workforce Plan for Children's Mental Health (2006)
- Discussion centers around the formation of the National Strategic Plan on Workforce Development in Behavioral Health. Includes a discussion of the Annapolis Coalition and its efforts related to workforce recruitment and retention. Ten strategic workforce goals are presented.
- Structures and Processes Supporting the Mission and Goals of a Family-run Organization: King County Blended Funding Project (2006)
- Using the King County Blended Funding Project as an example of a family-driven system that establishes collaborative partnerships with professionals and parents. The county was found to have a widely held theory of change, concept mapping was used to arrive at this finding.
- Community-based Theories of Change: Study Background and Design (2006)
- This article discusses the background and design of the Community-based Theories of Change Study.


text:
Wow, so only a little over six months ago, I wrote that the government was looking for developers for a hotel at FESA House in East Perth. And now they’ve actually completed the process – seems the government might be keen to get a few projects on the go before we all head off to the polls this year.
BGC have been selected to develop the site, which is now not just a hotel but also a ‘mixed-use development’. The briefing process looks set to take place over the next three months.
Apparently there were a number of tenders, with each submission including architects drawings and costing. Wonder how we can get a look at these?? (I’m not entirely convinced by BGC’s design shown above…) I would be interested in seeing what designers believed could be achieved on the site, its such a great location. I’d also like to see how many believed the existing building/s could be retained – according to BGC Director Julian Ambrose ” key heritage assets of the site would be kept and upgraded but the FESA office building would be demolished”, despite the Heritage Council of WA looking to list the Brutalist office building last year.


The SRM-T8000 is an exclusive driver unit (power amplifier) with 4-input selector developed in order to ideally drive STAX electrostatic earspeakers
The unit incorporates a high-quality double-axis 4-gang volume controller along with XLR connectors that can connect to all kinds of analogue line-level output terminals.
The hybrid amplifier configuration with strictly selected low-noise 6922 dual triode tube for the first stage and high-current emitter-follower at output stage brings out the maximum performance of earspeakers. Its natural un-coloured sound has been realized by eliminating the coupling capacitor that affects sound.
The balanced amplifier configuration with low-noise dual triode tube eliminated transformer or inverting amplifier after the XLR balanced input terminal.
Non-magnetic chassis construction is employed, and only the carefully selected electronic components free from aged deterioration are used taking both their sonic quality and performance into consideration.
The SRM-T8000 is equipped with “direct mode” function, enabling it to connect to preamplifier output terminal or to use your favourite Also, two RCA inputs and XLR balanced input can bypass the incorporated volume controller (Line 4 input does not have this function).
Optional extension slot (LINE4) is provided for future use. Refer to the instruction manual of this optional card.
The foot rubber of the SRM-T8000 features fire-resistant ultra-hard high- grip type and vibration-proof properties. So the unit hardly slides when placed on a table etc. Please lift it up when you move it.
Please note that this device can only drive STAX’s electrostatic earspeakers
1～115kHz per channel
<0.01% @1kHz per channel
Rated input level
Maximum output voltage
Unbalanced 50kΩ/ Balanced: 50kΩx2
RCA x2、XLR x1
Stax PRO bias output x2
Volume control bypass
Allows the use of an external preamp
95W（58W when idle)
320(W)×103(H)×395(D)mm / 12.6″ x 4″ x 15.6″
7.3kg / 16.1 lbs


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The Washington State Department of Health provided the following information today regarding COVID-19 and caring for your loved ones.
*COVID-19 Update, March 27, 2020*
Good evening! The state Department of Health wants to keep you as informed as
possible about continuing developments surrounding COVID-19, as well as to provide
guidance and resources you can share with employees, clients, or customers.
*Caring for loved ones*
Many of us are worried about or trying to take care of loved ones who are at higher
risk for getting very sick from COVID-19. Today we released guidance for taking care
of someone who is at high risk or is already sick with respiratory illness. If you
are caring for someone who is well now, but at higher risk of getting very sick from
COVID-19, there are some steps you can take now.
Contact their healthcare provider to ask about getting extra necessary medications to have on hand in case you and your loved one need to stay home for a prolonged period of time. If you cannot get extra medications, consider using mail-order for medications. Ensure you have enough medical supplies (oxygen, incontinence, dialysis, wound care) and create a back-up plan for getting more.
Make sure your loved one has non-perishable food items on hand.
Determine who can care for your loved one if you become sick. Stay in touch with others by phone or email. You may need to ask for help from friends, family, neighbors, community health workers, etc. Create an emergency contact list.
We have also included in this guidance practical strategies to reduce your risk of
getting sick while caring for someone even if you don't have access to standard
personal protective equipment (masks, gloves, gown). These strategies are not as good
as using the standard equipment, but they may help to reduce your risk of getting
sick, and are better than nothing. This guidance is available on the WA Department
of Health website
https://www.doh.wa.gov/Emergencies/NovelCoronavirusOutbreak2020/HealthEducation in 26 languages (under Information for families caregiving for loved ones).
We've had so many tests reported lately, it slowed down our reporting!
Keep checking our website for updates. Our most recent numbers show that 52,738
people in Washington have been tested for COVID-19. Of those, 3,723 people or about
7% have tested positive for COVID-19, and 175 have died of the disease.
Check in on someone you know who is balancing care of an
inter-generational household. How could you help?
Stay home and stay healthy!

domain: medical


text:
Keira Knightley was a floral confection for the Los Angeles premiere of her latest film, Seeking a Friend for the End of the World, which also stars Steve Carell and Adam Brody. The stunning British actress let her hair and makeup take inspiration from the delicate Valentino gown she wore to the premiere, which was embroidered with flowers front and back, as well as a metallic silver floral design on the skirt.
The 27-year-old actress had her short brown hair twisted loosely into a whimsical updo with lots of soft flyaways and a deep maroon headband of tiny flowers and leaves. The star, known for her bold brows, let these strong features frame her eyes, which were highlighted with delicate pink and muted brown shadows, mimicking the colors in her sheer gown. A touch of dark eyeliner and mascara helped her eyes to stand out, without creating too much drama. Her flawless complexion was highlighted with a warm pink blush, the same color used on her lips in a satin finish.
Knightley embraced her fairer skin tone for the premiere, showing off her back in the beautifully embroidered dress, which was thankfully free of the patchy fake tan faux pas the actress sported at the Dangerous Method London premiere in February.
Daily Mailpictures from the Seeking a Friend for the End of the World premiere show that Keira Knightley kept her accessories to a bare minimum, with no earrings, necklace, or bracelet and only her new engagement ring for decoration on her hands. She sported a nude manicure and low-key nude heels.

domain: entertainment


Filmmaker & Entrepreneur, Nollywood Actress, Multi — Brand Ambassador and human rights advocate Stephanie Linus has once again demonstrated an unrelenting fight against fistula and child marriage with her recent fistula awareness campaign in Maiduguri, Borno State.
Using her award-winning movie — DRY as a tool to educate young girls and women, the actress pushed forward her message for fistula prevention and child rights protection.
Obstetric fistula is a severe condition that has devastating consequences for women and young girls.
It is prevalent in poor countries, communities with high number of child brides and among women who give birth without access to medical help.
If a woman’s labor becomes obstructed, she could remain in excruciating pain for days before her baby is finally dislodged…


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Pagani is one of the most known cars made in Italy. It has a huge fanbase that loves it, and that’s why we created this page to share their story with you. In this post, we will tell you everything you want to know about the car, from its history to its technical specs.
In this blog we will cover the Pagani Cryo T Shock machine specs with pictures. The specs includes features, dimensions, weight, price and other important information about the product.
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text:
The Atlantic Celts: Ancient People or Modern Invention? (1999) by Simon James
The theory presented by Simon James in The Atlantic Celts: Ancient People or Modern Invention? is that the pre-Roman inhabitants of the British Isles were not a single people united by language and culture, that had invaded, destroyed or assimilated earlier unrelated peoples, nor indeed were they ethnically related to the Celts in mainland Europe. Discoveries in Britain of ‘La Tene’ style artifacts prove only the existence of trading links or raids to and from Europe.
The term ‘Celt’ was used by the Greeks and Romans as a designation for some of their barbarian neighbours to the north. ‘Celt’ as applied to the Scots, Welsh and Irish was not used before the eighteenth century, and appears to be an explanation entirely dependent on similarities in language. The term was quickly developed by other scholars to describe cultural or national identities.
In his 1707 work Archaeologia Britannica , Oxford scholar Edward Lhuyd proposed that similarities in the Welsh, Breton, Cornish, Irish, and Scots Gaelic languages were attributable to a common European origin. In that same year, the Treaty of Union between England and Scotland created a new political identity: ‘British’. The same political pressures sought the assimilation of Ireland through the Act of 1800. The confusion, however, may have originated with Julius Caesar. He identified three major tribes within Gaul (France) prior to the attempted invasion of Britain, “Gaul comprises three areas, inhabited respectively by the Belgae, the Aquitaini, and a people who call themselves Celts, though we call them Gauls. All of these have different languages, customs and laws.” The idea that people living out on the islands of the Atlantic fringe might call themselves ‘Celts’ came much later – and in effect involved the adoption of an imaginary ancestry and heritage. The Britons, who according to the Welsh triads, called themselves Khymry, were not Gauls, never called themselves ‘Celts’ but may have been closer related to the Belgae or Aquitani..
Archaeologists and historians have discovered that the ancient European Celts rose to the height of their culture in two main periods, the Hallstatt era, about 600 B.C., and the La Tene era, around 500 B.C. The names of these eras come from the places in Europe where the major cultural artifacts were found, Hallstatt in Austria and La Tene in Switzerland.
The author also raises some very interesting points about pre-historic society and how archaeologists and historians often seek to explain any changes in that society by reference to invasion from overseas, perhaps due to an instinctive belief that such societies are primitive and unchanging. The archaeological evidence from Iron Age Britain does not for the most part match that from the Celtic areas of central Europe. Refreshingly, he does more than critique the prevailing view. He argues that the ancient peoples of the British Isles should not be called ‘Celts’ because they were viewed by the classical writers as unrelated, culturally diverse and a sense of common identity that owed more to maritime contacts within Britain. The author also makes the same anti-invasion argument with respect to the Saxon invasions of the 5th century onwards. Again, perhaps for the same reasons, Oxford scholars introduced this idea as the Germanic Hanoverian monarchy consolidated power in Britain.
Simon James vividly and expertly sketches the clash between on the one hand the sense of Celtic-ness perceived by many people who live in Scotland, Wales, Ireland, Cornwall and Brittany – and which is to an extent the basis of a reawakening nationalism – and on the other the growing perception of archaeologists and anthropologists that the Celts as a race never existed at all and that the idea of an ancient Celtic culture is a modern construct. For example, if Celtic languages had been spread through the isles by mass population replacement, how do we explain the new DNA evidence for overwhelming continuity? There is striking and convincing evidence to support his case.
The Atlantic Celts is not just another book about the past. It gives a concise, readable account of the current controversies over British origins, and some insight as to how and why the myth of a Celtic past took hold.
Postscript: Dr. Barry Fell of Harvard University ( America BC: Ancient Settlers in the New World) discovered in New England many ancient constructions he identified as Celtic, including huts made exclusively of flat rocks and huge carved phallic symbols. Signs or characters etched on the surfaces of these constructions, along with linguistic remnants in the Algonkian language, seem to indicate that the Celts somehow got to the New World long before either Columbus or Leif Erikson. Could a Celtic iron sceptre have been buried in one of these huts and then found centuries later? Celtic swords and helmets with designs, distinct from those of the contemporary Greeks or other peoples, that feature stylized, fantastic figures with flowing tendrils, intertwined filigrees, and imaginary animals are an exciting link between Europe and America.

domain: history


text:
Why Lark Voorhies Wasn't at the Epic 'Saved by the Bell' Reunion
By Antoinette Bueno
Though Jimmy Fallon's amazing Saved by the Bell reunion on The Tonight Show featured fan favorites Mark-Paul Gosselaar, Mario Lopez, Tiffani Thiessen, Elizabeth Berkley, and even Dennis Haskins (Principal Belding), plenty of people were left wondering, "Where's Lisa Turtle?"
"Lark would have loved to be part of the Jimmy Fallon skit (as she is a big fan of the show), however due to an intense work schedule she was not available," her publicist told E! Newsabout her absence.
Voorhies made headlines in 2012, when she looked nearly unrecognizable in a Yahoo! video that went viral.
Her mother later told People that her daughter had been diagnosed with bipolar disorder, though she denied the claim when ET spoke with her in August 2012.
"I have no worries myself, nor do I exude, exhibit or possess within my living stratus any reason why someone should worry [on] my behalf," she said. "It's completely fictional."
As for Dustin Diamond, his absence from Wednesday night's reunion is perhaps more explainable. The 38-year-old actor pleaded not guilty to stabbing a man in December, and his tell-all book about his time on the beloved series -- 2009's Behind the Bell -- wasn't exactly positive.
"It is negative -- that I must say," Gosselaar said about his former co-star's book in a HuffPost Live interview last August. "Everything I've heard about his book is that it is negative, and I don't remember those things because my experience on the show was very positive."
The Franklin & Bash star has since taken to Twitter to thank fans for the explosive response to Fallon’s reunion.
"Thank you for all the love and support," he wrote on Wednesday. "I'm so happy you enjoyed tonight. Let's do it again sometime. Good night."
Thank you for all the love and support. I'm so happy you enjoyed tonight. Let's do it again sometime. Good night.

domain: celebrity


text:
extraordinary modern patio sliding door set suited for your home hrdwood stbility.
In here we portray of Elegant lively room interior afterward luxury furniture inside. This elegant flourishing room was meant when two color as the main themes. when two color they can designed it totally capably and great upshot i think. once red and white accent at the floor, or white couch and red items at the wall, they ornamented the buzzing room very perfected and precised. Check out this luxury animated expected like two color as main theme below. nHope after seeing this living considering red and white accent you got some challenging idea.


|Operating System||iOS 10|
|Color||Jet Black, Black, Silver, Gold, Rose Gold|
|Frequency Band||850 / 900 / 1700 / 1900 / 2100 / 2300 / 2500 / 2600|
|Screen Resolution||750 x 1334 pixels|
|Rear Camera Pixel||12 Mega Pixel|
|Front Camera||7 Mega Pixel|
|Internal Memory||32 Gb|
|RAM||2 GB RAM|
|Talk Time||Up to 14 h (3G)|
|Battery||Non-removable Li-Ion 1960 mAh battery (7.45 Wh)|
|Stand-by||Up to 10 days|
iPhone 7 dramatically improves the most important aspects of the iPhone experience. It introduces advanced new camera systems. The best performance and battery life ever in an iPhone. Immersive stereo speakers. The brightest, most colorful iPhone display. Splash and water resistance.1 And it looks every bit as powerful as it is. This is iPhone 7.
iPhone 7 Camera
An entirely new camera enters the picture.
Retina HD Display
The brightest, most colorful iPhone display yet.
iPhone. Now in stereo.
So smooth and responsive you won’t even notice it. And that’s the point.
Because iOS is engineered specifically for iPhone and iPad, everything looks and feels incredibly fluid. iOS uses a framework called Metal to maximize graphics performance. Whether you’re surfing the web, moving from app to app, or playing the most complex 3D video game, the graphics and responsiveness are amazingly smooth. No other mobile operating system is so effortless and natural.


text:
Base Shoe Style : Bliss (Mid)
**Full Customisation is available on this product at an additional cost**
• Handmade Satin Bridal Pump with cushioned insoles.
• Heel Height: 8cm
• Ivory, White, Black, Purple, Blue, Red, Pink, Yellow, Silver, Gold, Green, Grey, Orange - other colours available
• Full Customisation is available on this design
• Lace Overlay Finish
• Heel Height
• Closed toe or Peep Toe
• Sole Personalisation
• Shoes can be handmade to your own measurements
• Handmade shoes with cushioned soles for extra comfort
• Packaged in my own eco-friendly luxury shoe boxes and double boxed for delivery
• Gel heel protectors and toe inserts
• All designs take a minimum of 4 weeks from the date of ordering; processing times vary depending on style, and time of year.
If you have any questions regarding the design, sizing, customization or personalisation please message me, I will aim to work with you to create your dream shoes, Please check prior to ordering if you require your shoes for a certain date.


text:
MUSIC IN MOTION WITH ONE MORE NIGHT FT. JOSH HENDERSON
SATURDAY, APRIL 20, 2024
In Advance: $20
At the Door: $25
Josh Henderson brings together other contemporary Jazz titans – Rick Martinez, composer/guitarist Brendon Randall-Myers, Saxophonist Caroline Davis, and vocalist Sylver Wallace, to weave the soundtrack for his original performance project, One More Night. One More Night puts music in motion by weaving Jazz, Classical, and Rock styles with modern dance and theatrical elements, all based on an important bit of Mid-West History, “The Day the Music Died”.


text:
Anti-Islamic filmmaker questioned by LA police
Washington: A California filmmaker linked to a provocative anti-Islam movie that has sparked widespread violence across the Muslim nations was taken to a Los Angeles police station for questioning.
Nakoula Basseley Nakoula, 55, was interviewed at the Los Cerritos station near his home, the local Sheriff`s Deputy told the NBC news.
"He went to the Cerritos station to talk with probation officers. He`s not under any arrest," Deputy Sherif Don Walker said.
Nakoula, a self-described Coptic Christian, has been identified by US Federal authorities as the key figure behind "Innocence of Muslims," a film denigrating Islam that ignited mob violence against US embassies across the Middle East.
The questioning of Nakoula by police comes as Federal officials have said they were investigating the activities of Nakoula, who has been convicted of financial crimes.
The probation department is reviewing the case of Nakoula, who was previously convicted on bank fraud charges and was banned from using computers or the Internet as part of his sentence. The review is aimed at learning whether Nakoula violated the terms of his five-year probation.
Karen Redmond, a spokeswoman for the administrative office of the US courts, has confirmed he review is under way. If the probation department determines Nakoula violated terms of his release, a judge could send him back to prison.
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domain: law


text:
2 cans coconut milk
1 tsp curry powder
3/4 tsp salt
1/2 tbsp pepper
1/2 tbsp espelette pepper powder
Chocolate ShardsIn a medium bowl, melt Valrhona Dark Chocoalte over a bain marie (water bath), being careful not to allow any steam or water to mix with the chocolate. Once complete melted remove chocolate from over bain marie. Place a sheet of waxed paper and pour the chocolate over. Quickly spread the chocolate over the paper in a thin layer using the spatula. Place another sheet of waxed paper on top, pressing to release the air bubbles. Roll paper up tightly into 3/4-inch-wide roll and chill until set.


text:
Salinity is a common problem in irrigated agriculture, especially in areas of low rainfall and high evaporative demand (arid and semi-arid regions). Saline soils are however, not confined to the arid and semi-arid regions. They are also found extensively in sub-humid and humid climates, particularly in the coastal regions where the ingress of sea water through estuaries and rivers and through groundwater causes large-scale salinization. Since saline soils contain a major salt accumulation in the upper 30cm layer, seedlings are badly affected if planted at the surface. Sub-surface planting in holes of 15 cm diameter and 45 cm deep are dug and saplings are planted at a depth of 15 cm to minimize the adverse effects of high salinity. Another method is to plant on ridges of about 40 cm height and seedlings are planted on top of them. This method facilitates good aeration and salt leaching in waterlogged saline soils. Field observations, however, have indicated that ridges are generally unstable in the presence of excess salts, and it is difficult to irrigate saplings by a flood method to simultaneously affect salt leaching. A list of trees suitable for saline and waterlogged soils is as given.
The following is a list of species that can grow in various levels of saline and waterlogged soils.
|Scientific Name||Local Name||Native/Exotic||Salinity Tolerance|
|Albizzia lebbek||Black Siris||Native||Low|
|Millettia pinnata||Sukh Chain||Native||Medium|
|Salix tetrasperma||Indian willow||Native||Low|
|Leucaena leucocephala||Ipil Ipil||Exotic||Low|

domain: agronomy