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Self-care and mobility skills in children with cerebral palsy, related to their manual ability and gross motor function classifications.
ABSTRACT The aim of this study was to investigate the acquisition of self-care and mobility skills in children with cerebral palsy (CP) in relation to their manual ability and gross motor function.
Data from the Pediatric Evaluation of Disability Inventory (PEDI) self-care and mobility functional skill scales, the Manual Ability Classification System (MACS), and the Gross Motor Function Classification System (GMFCS) were collected from 195 children with CP (73 females, 122 males; mean age 8 y 1 mo; SD 3 y 11 mo; range 3-15 y); 51% had spastic bilateral CP, 36% spastic unilateral CP, 8% dyskinetic CP, and 3% ataxic CP. The percentage of children classified as MACS levels I to V was 28%, 34%, 17%, 7%, and 14% respectively, and classified as GMFCS levels I to V was 46%, 16%, 15%, 11%, and 12% respectively.
Children classified as MACS and GMFCS levels I or II scored higher than children in MACS and GMFCS levels III to V on both the self-care and mobility domains of the PEDI, with significant differences between all classification levels (p<0.001). The stepwise multiple regression analysis verified that MACS was the strongest predictor of self-care skills (66%) and that GMFCS was the strongest predictor of mobility skills (76%). A strong correlation between age and self-care ability was found among children classified as MACS level I or II and between age and mobility among children classified as GMFCS level I. Many of these children achieved independence, but at a later age than typically developing children. Children at other MACS and GMFCS levels demonstrated minimal progress with age.
Knowledge of a child's MACS and GMFCS level can be useful when discussing expectations of, and goals for, the development of functional skills.
[show abstract] [hide abstract]
ABSTRACT: Walking deterioration occurs frequently in adults with spastic bilateral cerebral palsy (CP), but their gait characteristics are largely unknown. The study aims were (1) to compare selected gait analysis variables between those reporting and those not reporting walking deterioration, and (2) to characterise the overall gait deviations and classify the gait patterns. Participants (N=16) were recruited from a follow-up study, had spastic bilateral CP, <40 years in 2006, GMFCS levels I-III, and could walk at least 10m without support. Eight reported walking deterioration (cases) and eight did not (controls). A theoretical framework linking work of walking, fatigue and deterioration in walking was developed. It was hypothesised that higher energy requirements during gait and larger gait deviations would be associated with deterioration in walking. Three-dimensional gait analysis was used to obtain centre of mass work, mechanical joint work, lower limb kinematics, movement analysis profile (MAP), and gait profile scores (GPS). There were no differences between the cases and controls in centre of mass work, joint work, or in the GPS. The largest MAP deviations were seen in sagittal pelvis, hip, and knee angles and foot progression. Crouch and asymmetric gait were common patterns. Walking deterioration could not be explained by these work and kinematic variables. An individual's perception of deterioration in walking is subjective, and may be experienced and interpreted differently across people. Larger, longitudinal studies on the natural history of walking in spastic CP are needed. Qualitative studies on the subjective experiences of walking deterioration are also warranted.Gait & posture 07/2012; · 2.58 Impact Factor


Billionaire businessmen Elon Musk and Jeff Bezos are in a battle for commercial dominance over the final frontier: space.
Musk’s company SpaceX plans to send a pair of humans to orbit the moon by 2018, while Bezos’ Blue Origin intends to deliver satellites, science experiments and eventually astronauts to the moon in the 2020s.
The two billionaires are both developing new rockets to go to the moon. Blue Origin unveiled animation of its new rocket design earlier this month.
SpaceX plans to have its 230-foot-tall Falcon Heavy rocket fly around the moon as earlier as next year. It’s shorter than Bezos’ rocket but capable of lifting 60 tons into orbit.
Blue Origin’s two-stage New Glenn rocket is 270 feet tall, 23 feet in diameter and capable of lifting 50 tons into orbit. Both rockets are much larger than NASA’s 212-foot-tall Space Launch System rocket, the first version of which should be capable of lifting 70 tons to orbit.
New Glenn’s engines will burn liquefied natural gas and oxygen, and will have more than 150 percent of the thrust of the Saturn V rockets that carried humans to the moon in the 1960s. New Glenn is expected to make its initial test launch prior to 2020.
SpaceX is modifying its current Dragon capsules to carry astronauts into orbit. The capsule has already successfully flown uncrewed resupply missions to the International Space Station (ISS) for NASA. The company will send the first crewed trip to the ISS in mid-2018, according to Musk. Blue Origin plans to launch its first crewed test flight this year and start commercial crewed missions to suborbital space in 2018.
Despite SpaceX’s more short-term timeline in the moon race, Blue Origin beat Musk’s company in the race to successfully land the first reusable rocket after officially going to space in November 2015. The race was marked by both billionaires aggressively tweeting at one another to explain why their rocket design was better.
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Abstract: This infographic contains the principle and characteristics of the most representative and widely used long-read sequencing platforms offered by Pacific Biosciences (PacBio) and Oxford Nanopore Technologies (ONT). It will give you the basic idea on how to choose the most suitable long-read sequencing method for your projects.Summary: Long-read sequencing technologies, also known as the third-generation sequencing, have developed rapidly over the past decade. The new generation sequencing overcomes the limitations of the second-generation sequencing technologies, which generally generate short reads of 100-700 bp in length. With much longer reads and the ability to detect epigenetic markers directly, this huge technological leap in sequencing offers better solutions for genomic, transcriptomic, and epigenetic studies.References: https://www.cd-genomics.com/wp-content/themes/v1/pdf/main/Long-Read-Sequencing-PacBio-SMRT-vs-Oxford-Nanopore.pdf
Ask the author a question about this poster.
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The National COVID-19 Chest Imaging Database (NCCID): what is it and how you can participate
Thomas Payne, Mark Halling-Brown, NCCID Collaborative
Chromatin Accessibility Assays: ATAC-Seq, DNase-Seq, MNase-Seq and FAIRE-Seq
NGS Panel: Hybridization Capture or Amplicon Sequencing?
Long-Read Sequencing: PacBio SMRT vs. Oxford Nanopore
Whole Genome Sequence for Cancer


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The service will offer the benefits of a cost-effective retirement plan with 3(38) investment fiduciary services, 3(21) named non-investment fiduciary services and administrative outsourcing, the company said. The Retirement Plan Exchange is designed so small-market retirement plan sponsors can enjoy the protections and convenience of fiduciary support along with total retirement outsourcing in a cost-efficient retirement plan.
The advantages of participating in it include:
- Cost-efficiency. Participating employers enjoy advantages through asset pooling, fee reductions as plan assets increase, and reduced audit fees for participating employers with over 100 eligible employees.
- Comprehensive professional fiduciary platform. Employers who participate in the Retirement Plan Exchange can enjoy the benefits, guidance and protections offered by the professional services of the 3(38) investment fiduciary, and the 3(21) named non-investment fiduciary.
- Administrative ease. Small businesses will now be able to take advantage of a retirement plan solution that allows retirement outsourcing by delegating duties and certain responsibilities to the 3(16) plan administrator, and the third party administrator. Every participating employer in the Retirement Plan Exchange will have access to a retirement specialist, financial adviser and investment analytics provided by Pensionmark.
- Plan design flexibility. Plan sponsors can choose from many plan design provisions that meet their unique needs, while outsourcing tasks such as managing the plan document, preparing or signing the plan’s Form 5500, and ensuring that legal notices are disseminated to employees.
- Automatic enrollment and deferral increase. To help plan participants save for retirement, the Retirement Plan Exchange offers default automatic enrollment at a 6% initial contribution rate with a 2% automatic increase in each of the next two years. Additionally, a Roth 401(k) provision will be automatically available to all participants who desire to save in an after-tax environment.
“This innovative retirement plan allows employers a strategy that has virtually the same employer involvement as a simple payroll-deducted IRA program, but with the benefits of a comprehensive 401k plan,” said Troy Hammond, president and CEO of Pensionmark.
More information is at www.pensionmark.com.

domain: finance


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Maintain lean muscle and curb cravings by munching on these high-protein, low-sugar bars.
Here's how to find the healthiest granola bars.
Brain foods protect from chronic illnesses like Alzheimer's and other dementias.
Experts say these are the protein bars that can help you in your weight loss journey.
A registered dietitian shares her top picks.
Take a look at the ingredients (and the science) before you unwrap one.
If the current plethora of protein bars overwhelms you, a NYC trainer shares two go-to picks.
Out of the hundreds (maybe even thousands) of protein bars out there, these are the ones you should buy.
Don't let this junk food in disguise sabotage your healthy eating.
From your weight to your overall wellbeing, here's how ditching these snacks may affect your health.
Now, you'll have the best and latest food and healthy eating news right in your inbox—every

domain: health


The man accused of killing an Orlando police officer and his pregnant ex-girlfriend will be back in court Monday – with a new person prosecuting the case.
Last week, State Attorney Aramis Ayala said she would not seek the death penalty for Markeith Loyd, charged in the January death of Sergeant Debra Clayton, who was attempting to stop Loyd after he allegedly killed Sade Dixon.
Governor Rick Scott took the case away from Ayala after she refused to step down from it, handing the case over to Brad King – who serves as the state attorney for a neighboring area.
Ayala made the assertion Monday in a legal motion that asks a judge to allow her to present that argument in court, saying Florida Gov. Rick Scott overstepped his authority when he pulled her off a case The motion claims that allowing the governor to interfere could undermine Florida's judicial system.
A spokeswoman for the governor didn't immediately respond to an email seeking comment Monday. King told NBC affiliate WESH-TV that he hasn’t decided whether or not he would pursue the death penalty.
Loyd is schedule to go to trial on May 1st in the death of Dixon and June 19th for the death of Clayton.


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The wife of the Osun State Governor, Mrs. Kafayat Oyetola, has said the state is working towards the total eradication of Female Genital Mutilation by 2023. Mrs. Oyetola spoke in her office while receiving the management of HACEY Health Initiative, who paid her an advocacy visit.
Oyetola, who highlighted the harmful effects of the practice on girl-child, said the prevalence rate of FGM was on the decline in the state. “The state is doing well in the area of advocacy against FGM, but we won’t rest; I have been going round to talk about it. Five communities in Irepodun promised not to engage in FGM again recently. Before 2023, the state must have gone far in eradicating this practice,” Oyetola said.
The Executive Director, HACEY Health Initiative, Rhoda Robinson, said the group conducted research in six Local Government Areas of Osun and discovered that FGM was on the decline. Robinson said the advent of COVID-19 in the country affected the progress made in advocacy against FGM in Osun last year.
She said, “More than 60 per cent of the victims of FGM in the area of our research are children under five years. The Stop project is another initiative of our group meant to stop FGM. We want the First Lady to join the campaign against FGM.”

domain: news


Hongdu Aviation Industry Group (HAIG) JL-8 / K-8
The JL-8 uses the WS-11, a Chinese copy of the Ukranian AI-25TL engine. The JL-8 avionics are inferior to the export K-8 version, which is equipped with advanced Western avionics and multi-function display systems.
Nanchang partnered Pakistan Aeronautical Complex in development of the K-8 Karakorum jet trainer (first flown November 1990). The JL-8 became the standard trainer of the PLAAF.


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This is one of those finds that is so special, so unique, so outstanding that we had to incorporate it into our business model. Each horse is hand-carved and painted with 5 coats of lacquer. They are finished with an attached leather saddle and bridal, real horse fair for the mane and tail, and brass stirrups. The hardware and base are extra strong, easily supporting an adult. They are beautiful to look at, but are made to be used. This is a most special gift for your horse-loving child.
Horses come in small, medium and large, though we do not recommend the small as we feel they are too small for your growing children. Medium and large designs can be seen at the gallery. Colors are white, red, black, natural and zebra stripes.

domain: artistic


Crop Images With CSS
Here's a simple trick that will let you "crop" an image using CSS and HTML without actually having to edit the image. We'll be the first to admit that this is a bit of a hack – if you have the time, you should really edit the images themselves instead. But, if you're looking for a shortcut, this can come in pretty handy.
We're going to be taking this penguin – he's 111 x 193 pixels now – and cropping him down to 51 x 133, cutting equal parts off the top and bottom, left and right. That's 30 pixels off of each dimension.
First, create a container
 with your new height and width specified. Make sure that overflow is hidden. Next, place your image in the middle with the full dimensions specified, but also with a negative margin-left and margin-top. If you're wanting to center the cropping, both of those should be exactly half the number of pixels you're wanting to reduce the height or width by.
That sounded more complicated than it actually is. Here, take a look at this example instead:
1.
 2.  3.

And here's the resulting penguin, or at least the parts of him that we've left:
Don't worry, no real penguins were harmed in the making of this post.
This post was published on September 20th, 2014 by Robert James Reese in the following categories: CSS, HTML, and Images. Before using any of the code or other content in this post, you must read and agree to our Terms & Conditions.


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Melody Maker Harmonicas Peaceful Dave's Stuff
The keyboard link function enables you to use an audio cable to send melody and chord data along with the audio playback. Use the keyboard's light-up function and …... This is the third part in the series of posts about ear training skills. Today I’ll talk about melody playback – the ability to play a melody after hearing it.
Play A Simple Melody — Irving Berlin Last.fm
Melody player is a free program for playing music files created with Harmony or Melody Assistant : Mus, Myr, Mu3, Mya as well as MID, ABC, MOD, S3M, XML, MXL files.... Recent Videos. Gospel Piano by Ear Tutorial: Learn to Play I Will Trust by Fred Hammond The Easy Way 🗣💨NEW Ceramic Coils – The SMOK Nord
How can you improve your melody playback skills in Grade
Now I can play a melody within seconds of having heard it. It takes time. Here’s a good procedure: Relax. Listen to the melody you want to play without your guitar in your hands. Still without your guitar, sing the melody. If you can’t sing it, you’re going to have a really tough time trying to play it. It doesn’t matter whether you have a singing voice or not, what you’re doing here how to make doberman ears stand up without cropping How To Play Your Favorite Melody with Arduino My Freeduino board playing a melody! In this tutorial, I will discuss how make Arduino play your favorite melody. There is a nice tutorial which illustrate the basic process here. But to play your favourite melody you will have to get the combination of notes, durations of individual notes and pauses as precise as possible. In this tutorial, I will
Ukulele Basics How to Play a Simple Melody dummies
Teaching how to play a melody by ear is extremely difficult. Part of the problem is that I’ve never struggled with it – I’ve always had excellent pitch, and I can pick out melodies and translate them to piano quite easily. Because this is a natural skill for me, I’ve never had to learn how to do it – I could just do it. how to play tiny king Piano, how to play a succession of notes using all the fingers. Leave a reply. How to play a melody. Imagine sitting at your piano and wanting to play a melody using all of your five fingers. Can you do that? Do you know the correct technique that allows you to play, for example, a succession of notes with multiple fingers? Today we will be approaching this issue, but we will take it through
How long can it take?
Download Piano Melody Free apk for Android (reviewed
- Chord Melody Guitar Noise Learn How to Play Guitar with
- Melody Playback Ear Training Piano Exam Test
- Melody Player Myriad
- Download Piano Melody Free apk for Android (reviewed
How To Play A Melody Playback
Stop • Play . Click Stop to halt playback and reset the Measure text box to its original value (or, rather, to the value indicated by the Play From controls; see below). Click Play, or press SPACEBAR, to begin playback. While the music is playing, the Measure text box shows you the measure being played. If you press SPACEBAR again playback will stop and the Measure text box will show the
- Recent Videos. Gospel Piano by Ear Tutorial: Learn to Play I Will Trust by Fred Hammond The Easy Way 🗣💨NEW Ceramic Coils – The SMOK Nord
- Piano Melody lets you play back top 80’s or 90’s songs or music from different genres and gives you a digital piano keyboard so you can play along. Each key is marked for rookie piano player like myself to keep track. If you’re on a tablet or a smartphone with a large screen, you can increase the keyboard size. Piano Melody also lets you change the piano volume or song playback speed
- Now I can play a melody within seconds of having heard it. It takes time. Here’s a good procedure: Relax. Listen to the melody you want to play without your guitar in your hands. Still without your guitar, sing the melody. If you can’t sing it, you’re going to have a really tough time trying to play it. It doesn’t matter whether you have a singing voice or not, what you’re doing here
- 16/02/2010 · Autoplay When autoplay is enabled, a suggested video will automatically play next. Up next How To Develop The World's Greatest Ear Part 1 - Duration: 14:07.

domain: hobby


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Complete the Look
A Dainty Diamond by The Yard Bracelet
The Hana is the ultimate everyday accessory! This Diamond by The Yard style bracelet features a dainty chain adorned with four equidistant shimmering stones, this bracelet is simple and stylish! Made with the highest quality 925 sterling silver, simulated diamonds, and plated in rhodium, this bracelet will keep its radiance for years to come!
This is a perfect addition to a proposal, can be used as a gift for a special occasion, or just to say, “I Love You.”
This bracelet comes in three sizes to fit different wrist types: Small (17cm), Medium (18cm) and Large (19cm).
- Modern Gents
Just wish the Large was a true large
I’m used to large bracelets being 8”, for us plus size gals, my fault for not reading the description and assuming it was 8”. Still love it will just be adding an extender.
I like it. I don't love it
The bracelet is pretty. It's just very light. Weight wise. It looks a little more heavy and detailed in the picture. It's still pretty and I wear it everyday
I wear it every day all day. I never take it off!
I have not taken the hanna off my arm since i have gotten it. I used to hate wearing bracelets because they were all too big and bulky. But this one id dainty with just enough sparkle. I have alot from modern gends and was only disappointed once but i have yet to call customer service and they are terrific. So im sure that they will help me out. If uou are on the fence i say go for it !!
Perfect size and dainty
Perfect size for someone with a small wrist. It’s very dainty but seems durable. I like the fact that this company has a great warranty (although I hope to never need to use it).
The bracelet reminds me of the "diamonds by the yard" bracelets of years ago. This bracelet is dainty with 4 stones. Simple but elegant. A perfect just because gift to yourself!

domain: design


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Sciatica is a form of neuropathy which causes pain and/or numbness in the back or leg(s); a condition that is caused by compression of the sciatic nerve as it emits from the lower spine, usually due to disc bulges, disc herniations, mechanical misalignment of the vertebra, or because of disc degeneration; also known as spinal arthritis (another mechanical joint problem of the spine).
The nerve transmissions become disrupted in the spine, much like what happens to water flowing through a hose if you “put a kink in it” – the normal flow of the water ceases.
In the nerve, this disruption of nerve impulses results in numbness, pain and most all the other symptoms associated with neuropathy.
Restless Leg Syndrome and Periodic Limb Movement Disorders are other such conditions also frequently caused by compressive joint problems. While not always, these conditions frequently contain many of the same neuropathic symptoms described in this report such as pain, tingling, burning, tightness and so on – as well as an uncontrollable urge to move the legs and feet to find relief. In fact, any nerve that becomes compressed due to mechanical joint problems, whether it be in the back, neck or otherwise, and causes a disruption of the tissue function that it serves, is scientifically known as mechanical neuropathy.
Traditionally, chiropractic has had wonderful success in helping most people with these mechanical kinds of neuropathy challenges.
Genetic & Hereditary
Moving from the most to the least common, the final category of neuropathies are those caused by a genetic or hereditary factor. They include neurological challenges such as Friedriech’s Ataxia and Charcot Marie Tooth Disease. These are fairly rare and while very significant to those afflicted, make up less than 1% of neuropathies. Multiple Sclerosis, while not necessarily known to always be hereditary, is also a form of neuropathy.

domain: medical


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Bill Willingham and Matthew Sturges are good writers. They do their best work outside of the superhero sphere, so many of you may never have heard of them, but they're both quite good, most famous for their work on Fables and Jack of Fables.
Recently - as in, this past Wednesday - the two of them together revived the House of Mystery, an old DC horror comic. The two of them have infused the now-Vertigo title with some bizarre Vertigo sensibilities. They tied it in with Sandman, Vertigo's biggest triumph, and set it up as a Worlds' End style storytelling device.
Within the House, a number of people are trapped. Occasionally, one gets to leave, though the residents don't know why. The rest...are trapped. They are bored. They have nothing to do, nothing to pay with, except stories. And so the residents tell stories, some biographical, some fantastical, many both.
The main story of #1 is mostly set-up, and it's interesting set-up, but where the book really shines is the short story told by Hungry Sally. It's one of the most visually horrific comics I've ever seen, but the art is still definitely compelling. If you don't mind being creeped out, definitely check this book out.
Oh, and as a bonus? Check out this absolutely stunning cover.

domain: literature


USB-C hubs are a hot commodity right now, with more new options to consider to power your devices. One of the latest entries — Sanho’s HyperDrive Power 9-in-1 USB-C hub — caught my attention first for its slimline design. The HyperDrive Power USB-C Hub is amping up the power for iPad Pros and MacBook Pro/Air devices.
Behind the Hub
Sanho Corporation is the Silicon Valley company behind this device. Sanho Corp started its HYPER product line nearly 15 years ago, offering a wide range of award-winning technology solutions. The portfolio includes IT and mobile accessories specifically for Apple devices as well as portable power, data storage, and connectivity products.
The 9-in-1 USB-C Hub
The HyperDrive 9-in-1 USB-C Hub has three USB-A ports, two memory card readers, HDMI, a headphone jack, and Ethernet. While some of the competitor hubs have at least one USB-A port, there are very few that give you three of these ports like HyperDrive Power does. Having this many USB-A ports allows you to plug in a keyboard, external drive, and mouse at the same time. Alternatively, it gives you the option to plug in multiple drives.
Each of the hub edges has ports or the cable connection, which means you can plug-in devices on all sides of this hub. The HDMI port enables s a Mac or iPad Pro to connect to most types of televisions and monitors for easy and fast streaming capability.
On the slender side of the hub, there are side-by-side SD and microSD memory card readers, making it a breeze to transfer photos. Finally, the gigabit Ethernet port uses the RJ45 standard, which is useful when there isn’t any available Wi-Fi or what is available is too slow or lacks security.
Just a word of caution, your iPad Pro must be using the iPadOS 13 in order to use all the ports on this hub.
What’s to Like?
Not that devices like a power hub have to look pretty, but this one sure has a good-looking presence. It’s sort of tear-shaped, providing a modern and sleek image that reflects the cutting-edge technology inside. The hub also complements the design of my Apple iPod Pro, which creates a seamless look. It’s like they were made to go together both in look and performance.
Another standout feature of this hub is the 3.5mm headset jack because this is not available on the latest iPad Pro. Having this adapter on the hub means I can plug in standard headphones to my iPad.
Also, even when all the ports are in use, my Mac or iPad could still get power because of the USB-C PD 60W port. Charging with this port is lightning fast. Then, there is the fact that HyperDrive Power’s USB-C port doesn’t have to be connected to a wall socket or even a battery to use its ports. Instead, the hub can get power from the computer it’s plugged into.
At $99, even the price seems fair for all that you get with this hub. The competition is priced at between $60 and $100 and has fewer ports or performance reliance.
Room For Improvement
There is more to love about this hub than not like about it. If there was anything I wish the company could fix with this hub, it would just be the built-in cable. The hubs current placement cable makes it awkward and near impossible to put in smaller travel cases. Other than that very small issue, this hub delivers on its promises.
Where to Buy
You can buy the hub in silver or space gray from the Sanho website or retail sites like Amazon and BestBuy.
This is the USB-C hub to get if you have Apple devices. It has the portability, reliability, design, and functionality that makes it the best value on the market today.
If you want a more streamlined USB-C hub for the iPad Pro, get the HyperDrive for iPad Pro, which is approximately $170 from the same company. However, the HyperDrive Power version works with the iPad Pro and any other USB-C devices.


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Background Differentiating between cardiac and obstructive causes for dyspnoea is essential for proper management, but is difficult in the prehospital setting.
Objective To assess if prehospital levels of end-tidal carbon dioxide (ETCO2) differed in obstructive compared to cardiac causes of dyspnoea, and could suggest one diagnosis over the other.
Methods We conducted a retrospective cohort study among patients transported by emergency medical services during a 29-month period who were diagnosed with either obstructive pulmonary disease or congestive heart failure (CHF) by ICD-9 codes. Initial prehospital vital signs, including ETCO2, were recorded. Records were linked by manual archiving of emergency medical services and hospital data.
Results There were 106 patients with a diagnosis of obstructive or cardiac causes of dyspnoea that had prehospital ETCO2 levels measured during the study period. ETCO2 was significantly lower in patients diagnosed with CHF (31 mm Hg 95% CI 27 to 35) versus obstructive pulmonary disease (39 mm Hg 95% CI 35 to 42; p<0.001). Lower ETCO2 levels predicted CHF, with an area under the Receiver Operating Characteristics Curve of 0.70 (95% CI 0.60 to 0.81). Using ETCO2 <40 mm Hg as a cut-off, the sensitivity for predicting heart failure was 93% (95% CI 88% to 98%), the specificity was 43% (95% CI 33% to 52%), the positive predictive value was 38% (95% CI 29% to 48%), and the negative predictive value was 94% (95% CI 89% to 99%).
Conclusions Lower levels of ETCO2 were associated with CHF, and may serve as an objective diagnostic adjunct to predict this cause of dyspnoea in the prehospital setting.
- Heart Failure
- Emergency Ambulance Systems
- Paramedics, Clinical Management
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What is already known on this subject
It is difficult for prehospital providers to determine between cardiac and obstructive pulmonary causes of dyspnoea. Evidence suggests that end-tidal carbon dioxide (ETCO2), which can be measured non-invasively, may be significantly lower in dyspneic patients suffering from congestive heart failure.
What this study adds
This study suggests that lower prehospital ETCO2 levels may predict a diagnosis of congestive heart failure upon hospital admission. This may provide an objective measure for field evaluation of patients with dyspnoea.
Differentiating between cardiac and obstructive causes is an important aspect of patient assessment in the setting of dyspnoea. However, many signs and symptoms overlap, making the proper diagnosis difficult.1 Diagnosis frequently depends on chest radiographs or serum N-terminal pro-brain natriuretic peptide (BNP) depending on the clinical setting.1 Prehospital providers are unlikely to have such diagnostic tests available to them, so a fast, non-invasive mechanism to objectively differentiate between these two common causes for dyspnoea could provide essential information.
Exhaled end-tidal carbon dioxide (ETCO2), a continuous variable that is determined by basal metabolic rate, cardiac output, and ventilation, can be measured non-invasively by capnography and may provide valuable information assessing acute dyspnoea.2 Obstructive pulmonary disease (COPD/asthma) is characterised in part by hypoventilation, retention of carbon dioxide and high PaCO2, while pulmonary oedema caused by congestive heart failure (CHF) is characterised by, in part, by poor alveolar oxygen exchange and increased ventilation.1 In a small prospective study, Brown et al3 demonstrated that ETCO2 levels were significantly lower in emergency department patients with CHF compared to those with obstructive pulmonary disease. Additionally, using an algorithm including ETCO2 levels in addition to serum BNP has been shown to improve appropriate diagnosis by physicians in the prehospital setting.4
The purpose of this study is to investigate the relative clinical value of prehospital ETCO2 and oxygen saturation (SPO2) measurements as mechanisms to differentiate between obstructive pulmonary and cardiac causes of dyspnoea. We hypothesise that lower prehospital ETCO2 levels may predict CHF versus obstructive pulmonary disease.
Design and setting
We conducted a retrospective cohort study among patients transported by a single emergency medical services (EMS) agency to a single hospital during a two-and-a-half-year period from January 2009 through July 2011 in Orange County, Florida. The institutional review board at the participating hospital approved the study protocol.
We evaluated the records of all adult patients (≥18 years) who had prehospital ETCO2 recorded who were transported to Orlando Regional Medical Center (ORMC), and were subsequently diagnosed with acute dyspnoea caused by obstructive pulmonary or cardiac disease. During the study period, the standard practice for the participating EMS agency was to record ETCO2 level as part of the initial set of vital signs in patients requiring ALS. Exclusion criteria included patient refusal to consent to standard therapy and interventions, paediatric patients (<18 years old), and patients without recorded prehospital ETCO2. Orange County, Florida is an urban/suburban region with a population of approximately one million individuals. ORMC is a Level One trauma centre with an ED volume of approximately 70 000 visits per year.
Initial out-of-hospital vital signs documented by first-arriving EMS personnel including RR, systolic BP (SBP), diastolic BP (DBP), pulse (P), oxygen saturation (SPO2), and ETCO2 were obtained using LIFEPAK 12 multiparameter defibrillator/monitors. Prehospital measurement of ETCO2 is a standard practice in Orange County, and is performed by paramedics following protocols. ETCO2 was measured via microstream capnography using LIFEPAK 12 devices (PhysioControl, Redmond, Washington, USA). Microstream capnography is an ETCO2 sampling method using molecular correlation spectroscopy applicable to intubated and non-intubated patients. ETCO2 was recorded when capnographic wave peaks were at a constant end-tidal for 3–5 respirations as directed by protocol.
Patient age, gender, ETCO2, RR, SBP, DBP, P and SPO2 were obtained from prehospital run reports. Principle diagnosis of obstructive pulmonary disease, including chronic obstructive pulmonary disease (COPD) or asthma, and cardiac disease, including CHF or pulmonary oedema, were obtained from the hospital chart and defined by International Classes of Disease, ninth edition (ICD-9) codes. The ICD-9 code for the patient's principle diagnosis from the specific admission was used, so patients with a history of both types of disease were placed only in the group whose exacerbation caused the admission. ICD-9 codes used included 491 and 493 for obstructive disease, and ICD-9 428 for CHF. Mortality and admission to hospital or intensive care unit (ICU) were also obtained from the hospital chart. Records were linked by manual archiving of EMS and hospital data.
Data were described using means and proportions with 95% CIs. Data were assessed for variance and distribution, and comparisons between CHF and obstructive pulmonary disease were performed using Fisher's Exact test, and independent sample t tests with pooled or separate variance, as appropriate. The accepted normal range of ETCO2 is 30–40 mm Hg, so for sensitivity, specificity, positive/negative predictive values, and likelihood ratios, data was analysed using an ETCO2 <40 mm Hg as a cut-off. Receiver Operating Characteristics curves (ROC curves) were constructed to assess the performance of ETCO2 and SPO2 for predicting CHF. As a statistical measure, the area under the ROC curve measures the accuracy of a test—an area of 1 or −1 represents a perfect test, an area of 0.50 represents a poor test. Significance was set at 0.05. Data were analysed using STATA (StataCorp, College Station, Texas, USA).
There were 106 patients with a diagnosis of asthma/COPD or CHF who had prehospital ETCO2 levels measured during the study period: 75 patients with a diagnosis of asthma/COPD and 31 with CHF. No patients were intubated prior to hospital arrival. The mean age was 59 years (SD20), 58 (55%) were women, 82 (77%) were admitted to the hospital, 5 (5%) were admitted to the ICU, and 1 (1%) died (see table 1). Patients with CHF were older (69 vs 56 years old, p=0.003), and more likely to be admitted to the hospital (68% vs 100%, p=0.002). Patients diagnosed with CHF also had higher RRs (31 vs 26 bpm, p=0.046) and DBP (98 vs 86 mm Hg, p=0.009) than those with COPD/asthma (see table 1). ETCO2 levels were significantly lower in patients with cardiac causes of dyspnoea. Mean levels of ETCO2 in patients with CHF were 31 mm Hg (95% CI 27 to 35 mm Hg) compared with 39 mm Hg (95% CI 35 to 42 mm Hg, p<0.001) for those diagnosed with COPD/asthma (see table 1). There was no significant difference in the mean SPO2 levels in each group; 93% (95% CI 92% to 95%) in COPD/asthma, and 93% (95% CI 90% to 96%, p=0.83) in CHF.
Using ETCO2 <40 mm Hg as a cut-off for hypoventilation (see figure 1), the sensitivity for predicting CHF was 93% (95% CI 88% to 98%), the specificity was 43% (95% CI 33% to 52%), the positive predictive value was 38% (95% CI 29% to 48%), and the negative predictive value was 94% (95% CI 89% to 99%). The positive Likelihood Ratio was 1.63 (95% CI 1.31 to 2.03), and the negative Likelihood Ratio was 0.15 (95% CI 0.04 to 0.60).
To evaluate the usefulness of non-invasive measures for oxygenation (SPO2) and ventilation (ETCO2) in the prehospital setting, ROC curves were constructed to determine the accuracy of ETCO2 and SPO2 in predicting CHF. The area under the ROC curve for predicting CHF was 0.70 (95% CI 0.60 to 0.81) for ETCO2 and 0.50 (95% CI 0.37 to 0.62) for SPO2 (see figure 2).
This study demonstrates that prehospital ETCO2 levels are lower in patients presenting with dyspnoea caused by heart failure, as compared with obstructive pulmonary disease, and that ETCO2 outperforms SPO2 at predicting CHF in this patient population. Prior reports have similarly found that ETCO2 is lower in patients with CHF versus those with obstructive pulmonary disease,3 and have described using ETCO2 in conjunction with serum BNP to improve diagnostic accuracy in the prehospital setting.4 ETCO2 has also been described as having prognostic value in CHF patients at rest5 and undergoing exercise testing.6 The use of capnography to measure ETCO2 may help differentiate obstructive versus pulmonary causes of dyspnoea in an environment where chest radiographs and serum BNP levels are not available.
ETCO2 is a continuous variable that is determined by basal metabolic rate, cardiac output and ventilation, and abnormal levels may reflect derangement in perfusion, metabolism or gas exchange. Capnography is used for monitoring ventilation of sedated patients,7 evaluation of proper endotracheal tube placement,8 and confirming return of spontaneous circulation during cardiopulmonary arrest.9 Recent studies have suggested low ETCO2 levels are associated with disease severity and mortality in shock,10 sepsis,11 metabolic disturbances12 and trauma.13 Therefore, the lower ETCO2 levels found in CHF may be caused by a number of different factors, including increased ventilation or decreased perfusion. In the current study, patients with CHF also had an increased RR, suggesting that the decrease in ETCO2 may have been secondary to hyperventilation. The relationship between ETOC2 and CHF may be multifactorial, since the combination of factors that produce ETCO2 (metabolic rate, cardiac output, and ventilation) all might be deranged in the setting of heart failure.
A primary physiologic cause of dyspnoea in obstructive pulmonary disease is hypoventilation and resulting hypercapnia.1 The relationship between ETCO2 and partial arterial carbon dioxide (PaCO2) in the setting of dyspnoea has not been completely elucidated. Prior studies have shown that ETCO2 may predict PaCO2 in patients with asthma,14 and ED patients with acute dyspnoea.15 However, the accuracy of ETCO2 to predict PaCO2 in acute dyspnoea has been questioned.16 In the current study, we did not assess PaCO2 since we were evaluating prehospital ETCO2 prior to hospital arrival, and few of the enrolled patients had ABG analysis performed in the ED.
Since elevated ETCO2 likely reflects hypercapnia, we examined the relationship of lower levels with CHF. A prior report suggested ED patients with ETCO2>37 mm Hg are unlikely to have CHF.3 Here, we found ETCO2 of less than 40 mm Hg had a high sensitivity, negative predictive value, and negative likelihood ratio, suggesting patients with dyspnoea and lower ETCO2 levels are more likely to have a cardiac aetiology. These findings demonstrate potential for prehospital providers to discriminate between causes of dyspnoea.
Using waveform capnography to assess patients with acute dyspnoea may provide information beyond the ETCO2. Krauss et al17 demonstrated significant difference in the shape of the capnogram in obstructive disease versus those with normal and restrictive lung disease. It is possible that a combination of measurements including the ETCO2, alveolar plateau elevation angle, or take-off angle of the ascending phase may further elucidate obstructive pulmonary disease from other causes of acute dyspnoea.
Non-invasive methods for distinguishing disease processes play an important role in prehospital medicine. Prior reports have found novel applications for sonography in prehospital patients with acute dyspnoea, demonstrating high sensitivity for pleural effusions in patients with CHF.18 In the future, combining sonography with capnography may provide a method for determining appropriate treatment in the field.
There are several limitations to this study. This study was performed retrospectively and, thus, is subject to selection bias. The relatively small sample size may have contributed to the inability to define an ETCO2 cut-off with higher specificity and positive predictive value. This study was conducted using the data from a single EMS agency transported to a single hospital, and may not be applicable to all settings. Per protocol, ETCO2 was collected by paramedics only in patients requiring ALS care, so patients deemed to require only basic life support in the prehospital setting were excluded.
Lower levels of prehospital ETCO2 were associated with having CHF, and ETCO2 was better than SPO2 in distinguishing between obstructive pulmonary and cardiac disease. This suggests that ETCO2 could be a valuable tool for EMS providers assessing respiratory distress.
Contributors CLH, SS, GR and LP planned the study. CLH and SS obtained the data and performed chart review. CLH and LP performed data analysis. CLH, SS, GR and LP created the manuscript. CLH submitted the manuscript, and is responsible for the overall content as the guarantor.
Competing interests None.
Ethics approval ORMC IRB.
Provenance and peer review Not commissioned; externally peer reviewed.


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What is Hip ?! Is a urban & popular musical media
What is Hip ?! aims to visit different eras and musical styles sailing between jazz-rock-fusion-funk-soul-éléctro, with always the same want to groove and sound texture.
What is Hip ?! it is a question of introducing to the broad audience a music known most often by initiated in an energetic and popular mode. Away from the mainstream pop, ignoring the conventions,
What is Hip ?! is fun, real encounters, unpretentious and joyful discovering of good music.It is a cultural agenda of the week's concerts in Brussels as well ; and guests every week.
What is Hip ?! is played on the offbeat side of its presenters who have the art of handling surrealism while probing the un-agreed and the unsuitable. By waltzing the monotony of days, he transports us into a funny, second-degree and improbable universe.
Migou is a real jack-of-all-trades, curious about others. He’s also a songwriter who writes for himself as well as for other artists. As an anthropologist, he’s always been interested in human beings more than in pure profit. Talking about music, he’s looking for the groove before anything else. He also favours the warmth, sensual and swaying rhythms and has a soft spot for deep voices. His specialty finds its roots in hyperlinks between songs that he introduces and other “pieces of art” from the literature, cinema, even fine arts and natural science. Migou will always be an anthropologist who cares about creating bridges between cultures.
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Join our training course for 5 sessions in our radio and mix with professionals of this field.
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Hours: every Saturday from 1 to 3pm
Price: 25€/pers/session or 100€/pers for 5 sessions Inscriptions via mail: the number of participants is limited to 5 per session. Find more info on our Facebook Page


text:
SUPERIOR COURT: Three face charges for attempting to escape police
Sun | Local
Three men have been charged with felonies after they allegedly tried to escape police who were chasing them.
* Clifford J. Hankins, 23, of Washington Avenue in Bremerton was charged with felony eluding of police. He allegedly fled a traffic stop at Sixth and Hewitt in Bremerton on Jan. 10, doing up to 60 mph on several city streets where the speed limit is 25. The chase ended when he jumped out of his rolling car in the Burger King parking lot on Warren Avenue and ran, his case file said.
The car hit a fence. An officer caught him and arrested him, the charge says.
* Jonathan R. Brillante, 19, of Holland Road in Central Kitsap was charged with felony eluding of police.
He allegedly fled nearly the length of Pine Road on Jan. 12, before crashing into a yard at its intersection with Sheridan Road. He was doing 80 mph when he blew the stop sign at Sylvan Way, where two cars were waiting to cross, the pursuing officer said. The officer said he originally tried to stop Brillante for doing 72 mph in a 35 zone.
* Sean T. Carpenter-Woolard, 28, of Galyan Drive in Bremerton was charged with possessing a stolen Geo Tracker with license plates stolen from some other car Jan. 9. He ran from the car on Holly Road and eluded a canine trail, the charge said, but was arrested after turning up at a nearby home, saying he'd had car trouble and needed a ride.
Bessie L. Cooper, 20, of Fox Island, also ran from the Tracker when it stopped, but was quickly arrested. She had methamphetamine and was charged with drug possession.
Others charged with felonies in Kitsap County Superior Court recently include:
* Jonathan E. Lundeen, 30, of Auburn was charged with felony harassment and theft.
Prosecutors say he threatened his estranged wife with a large flashlight Jan. 7 and took her 1989 Ford Mustang during a confrontation on Riddell Road.
* Tony J. Tassin, 43, of E Street in Navy Yard City was charged with forgery. He was the latest of a number of people to present a phony insurance check to the Money Depot check cashing business in Port Orchard, the case file said. He allegedly did it Dec. 21, presenting as a $2,895 check one that actually had been written to a Port Orchard chiropractor for $9.
* Gregory A. Webster, 38, of Shamrock Drive in Bremerton, who also goes by Comstock, Colstock and Logan, was charged with third-degree assault.
He allegedly was with two others when they assaulted a man and a woman in the 1700 block of Rainier Avenue on Jan. 3. She went to Harborview Medical Center in Seattle and was released with a neck brace and her face black and blue, the case file said. He is accused of assaulting her. There was no mention of charges against the others.
* Norman R. Adams, 33, of Gunderson Road in North Kitsap was charged with possessing methamphetamine with intent to sell it. His Camaro was impounded in the 3400 block of Kitsap Way by Bremerton police for an unspecified reason, and was searched by a drug dog under terms of a warrant Dec. 27.
Officers said they found three bags of meth, a scale and calculator. The court file said there also was cocaine and heroin in the car, but he hasn't been charged in connection with those.
* James R. Meek, 30, of Chestnut Street in Bremerton was charged with first-degree child rape. He allegedly used his hands to molest a girl, now 10 years old, over 18 months ending this month.
* Marcelo B. Lamont, 29, of Hostmark Street in Poulsbo was charged with first-degree theft. He allegedly took $2,554 in a bag from Elmo's Book Store in Bremerton on Jan. 8. He made up a story about the money simply disappearing, but confessed to taking it when he failed a lie detector test, his case file said. He returned all of the money, it said.
* Brandon C. Van Eaton, 18, of South Summit Avenue in Bremerton was charged with car theft. He allegedly was found in an inoperative car that had been pushed out of a parking lot in Westpark without the owner's permission Jan. 12.
Reach reporter Travis Baker at (360)792-9217 or at email@example.com.

domain: law


text:
Dec 19, 2010, 10:48 PM EDT
The Colorado Avalanche have quietly put together an outstanding follow up campaign after their breakthrough 2009-10 season. While their Pacific Division lead over the Vancouver Canucks is unstable at best, their six-game winning streak, league-best 121 goals scored and impressive array of speedy young talent indicates that they’re going to be a factor in the Western Conference for quite some time.
That’s the good news. The bad news is that they will have to keep their locomotive offense going without Kyle Quincey, a defenseman who has prospered since he left the Detroit Red Wings organization to play with Colorado and Los Angeles.
Colorado reports that the defenseman will undergo season-ending surgery on his shoulder in the “near future.” While Quincey has regressed after underrated seasons (only one assist and a -5 rating in 21 games this season), losing the 25-year-old defenseman still a tough bit of news for the team.
“This is the best course of action for Kyle and his future,” said Avalanche team physician Dr. Andrew Parker. “After physical and diagnostic tests, the decision has been made to repair his shoulder at this time.”
- Leafs re-sign Reimer — two years, $4.6 million 18
- Gorges still can’t explain falling out of favor in Montreal 13
- Eller, Habs agree to four-year, $14 million contract 10
- Cory Sarich hospitalized following cycling accident, expects ‘full recovery’ 7
- Stamkos shrugs off talk of LeBron-like homecoming to Toronto in 2016 30
- Avs and O’Reilly agree on two-year deal, but questions remain 45
- Rangers and Kreider avoid arbitration, agree on two-year deal 39
- Zuccarello takes Rangers’ one year, $3.5M deal 42
- Advancement? Leafs sign Booth for one year, $1.1M 25
- Leafs hire 28-year-old stats advocate as assistant GM 32
- NBC Sports to air over 100 NHL regular-season games in 2014-15 (69)
- Vanek connected to federal gambling investigation (61)
- Lucic regrets handshake-line actions, but isn’t apologizing (58)
- Report: O’Reilly wants $6.7M deal, Avs counter at $5.5M (58)
- Red Wings unveil plans for new arena, look to open in 2017 (57)


Anna Faris Knew Exactly When Chris Pratt Was Going to Propose
Anna Faris may be completely impressed with her husband Chris Pratt's acting abilities, but it sounds like the Guardians of the Galaxy star isn't quite as skilled at keeping secrets. It turns out the actress and mom to the couple's son, Jack, knew months ahead of time that Pratt was going to pop the question-and totally managed to keep her cool!
"We had talked about getting married and we were living together," Faris explained on the latest episode of her podcast, Unqualified, according to ET. "One day I found a bag from a jeweler on the floor of his truck, so I knew something was coming. But it took months." How the actress managed to keep the surprise to herself, we'll never know. Because Pratt didn't end up proposing for seven whole months!
"My whole family took all of us to Italy and apparently he lugged [the ring] all around Italy and held on to it for a couple months," she said. "I think I knew for like, seven months, and so he finally asked me on my birthday." Let's just take a minute to image how stressed Pratt must have been trying to keep that ring safe (and hidden!).
In any case, Faris admits her reaction may have let on that she'd seen the proposal coming. "I confessed because he was like, 'You knew this was coming,'" she shared on the podcast. Oops! Fortunately, she said "yes," and the couple has been setting all of our relationship goals ever since.
- This Couple Traded Their Original Wedding Venue—Central Park's Boathouse—for the Bride's Childhood Home in Illinois
- These Are 20 of the Best Bridal Shower Favors Under $10
- What to Bring to Your First Wedding-Dress Shopping Appointment
- 3 Eco-Friendly Wedding Flower Ideas That Are Simple and Impactful


text:
We will find really many different types of payment methods for online casinos. From internet portfolios as PayPal or Neteller, after banking cards and prepaid cards, as well as bank transfers (in most cases are only available for payments). Most methods are really safe - some less, some more. What is the most important for players is the availability of these methods. To a large extent, the number of deposit methods that we can use are strictly dependent on our country of residence.
For example, the British also uses PayPala very often - in principle, this has never been possible when it comes to payments to online casinos. To a large extent because of for centuries, unclear rights regarding the legality of online casinos in our country. Currently, the situation in this area has already been explained - yet, however, for players - it is definitely not a satisfying solution.
The number of available deposit methods for people living in Australia is currently smaller than one day. The most painful is the loss of international giants - the Skrill portfolio and Neteller, which were actively used by casino players and bookmakers to make transfers to gambling platforms. Currently, however, due to new legal regulations clearly prohibiting games in "illegal" (ie foreign) bookmakers and online casinos, both methods are not available to us.
However, a lot of alternatives have quickly appeared on the market. Our choice is still very limited compared to other European countries as United Kingdom or Sweden, but easily everyone is able to find something for themselves. We can use, among others, from very good online portfolios as eCopayz, Trustly, or even cryptowalut, which in the case of online casinos become an increasingly common solution.

domain: economics


Fulton Custom Boat Roller Pair Guide-Ons
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The rollers are held by a stainless steel pin that ensures proper hull contact in all load conditions. They come with mounting hardware and instructions for convenience. The universal mounting system mounts allows the guide-ons to be installed on a range of trailers. Plus, their adjustable angle ensures optimum fit.
Features of Fulton Custom Boat Roller Pair Guide-Ons
Manf. Part # BGR20 0101
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text: ShareTweetPin itShareEmailMore Bread Basket by Stephen MeehanOctober 4, 2020 0 Bread Basket Why has Kent County been known as the "Bread Basket"?A. Kent County is the home of the largest independently owned feed mill on the Eastern Shore.B. Kent County grain makes the best bread.C. Successful grain production and concentration of millers during the Revolution.D. Vita Foods was a major regional baker in the 1960s. Time is Up!

domain: agronomy


DePauw Jazz Festival Closing Concert
DePauw Jazz Ensemble with Pharez Whitted '82
Saturday, March 12, 2016
5-7 p.m. Awards Presentation & Closing Concert
Green Center, Moore Theatre
Love jazz? Steve Snyder, director of the first DePauw Jazz Festival, has lined up a full day of nothing but: performances from high school and middle school jazz ensembles across Indiana, valuable clinics and master classes with professional jazz musicians--topped off with a closing concert by the DePauw Jazz Ensemble and guest trumpeter Pharez Whitted. A 1982 graduate of DePauw, Whitted leads the acclaimed Pharez Whitted Sextet. He's worked with such musical giants as Wynton and Branford Marsalis, George Duke, Kirk Whalum, The Temptations, Lou Rawls and Ramsey Lewis. Sure to be a sensational show.
General admission: $5
Tickets for seniors, youth and all students are free.
Green Center for the Performing Arts, Moore Theatre (View)
605 S. College Ave.
Greencastle, IN 46135
|Kid Friendly: Yes!|
|Dog Friendly: No|
|Wheelchair Accessible: Yes!|


text:
Plan by a 37-year-old Ibadan-based woman and her children to be located to the United States by her husband has been foiled.
Mrs Bukola Ogun, who confessed how she planned her own kidnap in order to scare her husband while being paraded, alongside others by the Oyo State Commissioner of Police, Abiodun Odude, said that her husband, who has dual citizenship of Nigeria and the US, worked for the stock exchange and that the whole thing started like a joke.
She added that she lodged herself in a hotel at Imalefalafia area of Ibadan, explaining that “I just woke up one day and thought of a way to make my husband see reason why he should use his American citizen status to take me out of the country. It all started like a child’s play. I told my supposed abductors to tell my husband that the ransom was N10m although I knew he would not be able to pay such money. He is just a salary earner. I lodged myself in a hotel and I was there for two days. I went back home on the third day and no ransom was paid.”
She was said to have conspired with three other persons, including her cousin, to arrange the crime. The suspects arrested are Kayode Adepoju and Olalekan Anafi.
Speaking on how the suspects were arrested, the police boss said: “The Special Anti-Robbery Squad of the command arrested a business woman who conspired with a three-man gang to orchestrate her own kidnap in order to fraudulently obtain money from her husband, Kayode Ogun, who lives with her in Ibadan.
“The incident happened on July 4, 2017 at around 7.45pm when three armed hoodlums stormed the residence of the supposed victim and kidnapped her. Barely four hours later, the suspects contacted the husband and demanded a N10m for her release.
“The husband, who did not know that it was all arranged by his wife, contacted the police and a manhunt was launched for the hoodlums. Two male suspects were later arrested.”
It was learnt that the husband, who resided in the US for many years before returning home a few years ago, had already begun the process of relocating the family to the US but the wife thought the process was too slow. They have been married for six years and blessed with two children.
The cousin, Adepoju, said, “She called me and said she wanted to stage her kidnap. She said she wanted to scare her husband with it so that he would see reason why it was necessary for him to take her abroad. We did not collect any money from the husband and we did not use any weapon in the operation. I was arrested a day after we kidnapped her.”

domain: sociology


text:
Michael Phelps gave Extra the down low on his perfect, broad swimmer body life. He is not dating fellow swimmer Amanda Beard. "No, I'm not dating Amanda Beard. I'll say that. I think she has a boyfriend." As far as being single, "Part of my life is kept to myself. I'm able to relax and be with my friends. Those pretty much are the only people who really know the answer to that question."
He thinks it's neato that Carrie Underwood has a crush on him. "That's the first I've heard of that. That's pretty cool." If he could pick an actress to play his leading lady in a movie about his life, who would it be? "Cameron Diaz seems pretty cool. She seems like she has a cool personality."
Phelps will bring in around $40-100 million in endorsements. He says, "It's not about the money. I love what I do. The one thing I'm really looking forward to doing is raising the bar in the sport of swimming and promoting it- to get new faces involved in the sport."
Watch Extra tonight for the full interview!
Image: Flawed Hollywood
Tuesday, August 19, 2008
Posted by Gabs at 12:49 PM

domain: celebrity


text:
Dr Sid Ogra
Specialist in eyelid and tear duct disorders (Oculoplastics)
Specialist in Cataract surgery including refractive lens surgery
Oculoplastic Fellowship, Hereford, UK 2019
Observerships in Stanford (USA), and Seoul (South Korea)
About Sid's career
Sid is excited to be a member of the Auckland Eye team, and to provide specialist Oculoplastic care to the population of Auckland.
After graduating medical school (with distinction) in Auckland, Sid knew that Ophthalmology was the right fit for him. He completed his Ophthalmology training in Auckland, Rotorua, and Wellington, and was able to travel to the UK to further refine his skills in Oculoplastic surgery. Further experience followed at the prestigious Byers Eye Institute in Stanford, USA, as well as Samsung Medical Centre in Seoul, South Korea.
Sid is a very active Ophthalmologist, working across the Auckland region in public as well as private practice. He currently consults in our Takapuna, Remuera and Ormiston practices. He is also working across all three Auckland district health boards (Auckland, Counties-Manukau, and Waitemata).
He has a strong belief that doctors and patients must work together as a team to achieve the best results. This means empowering his patients with all of the relevant knowledge, discussing the options, and coming to a decision together regarding the best fit for them.
Please see Sid to discuss options for:
- Droopy eyelids
- Heavy upper eyelids (Blepharoplasty)
- Double eyelid surgery (Asian eyelids)
- Cosmetic eye surgery
- Blocked tear ducts
- Watery eyes
- Skin cancer removal and reconstruction
- Any other eyelid cysts/lumps/bumps
- Eyebrow lifts
- Cataracts and blurred vision
Sid enjoys learning about new things in his spare time, whether it be related to mechanical things or food science. He is into all types of sports, and enjoys the outdoors with his young family when possible.


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text:
WNS series gas / oil fired hot water boiler adopts advanced structure, the boiler structure is compact, occupies a small area, installs quickly. The boiler adopts advanced mechatronics automatic control technology, high quality silicic acid encryption and insulation, reduce heat loss. Horizontal industrial boiler composes furnace body, access door hole, front and rear smoke chamber, insulation layer cover, burner interface, pipes, valves and instruments, platform and stairs, instruments and safety devices, supporting accessories, electrical control cabinet.
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domain: pet


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Register to Vote
You can register to vote in Fitchburg if you are:
- A U.S. Citizen
- A resident of Massachusetts who lives in Fitchburg
- 18 years or older
- Not currently incarcerated by reason of a felony conviction.
Fitchburg residents who are 16 or 17 years old may pre-register to vote by following the same process as someone 18 years or older. You will receive a confirmation of your pre-registration by mail and when you turn 18 you will be added to the voter list.
How to Register to Vote
There are several ways you can submit your voter registration form. For additional information about registering to vote you may visit the Secretary of the Commonwealth Registering to Vote page.
Register to Vote Online
You may submit your application online via the Secretary of the Commonwealth's online registration software. You may also pre-register, update your address, update your name, and change your political party designation on the software.
When you register online your forms must be submitted by 11:59 PM on the voter registration deadline for the upcoming election.
Register By Mail
You can register or pre-register to vote with a mail-in voter registration form. You may print, fill out and sign the voter registration form. Mail the form the the Fitchburg City Clerk, 718 Main Street, Fitchburg, MA 01420. Your voter registration form must be postmarked by the voter registration deadline.
If this is your first time registering in Massachusetts, please include a copy of your identification which shows your name and address.
You can register or pre-register to vote in Fitchburg by visiting the Fitchburg City Clerk's Office, the office of the Secretary of the Commonwealth Elections Division or any of the Secretary of the Commonwealth's regional offices.
If this is your first time registering to vote in Massachusetts please bring an ID which shows your name and mailing address. Voter registration forms completed in-person are valid on the day which they were signed. To enroll for an upcoming election please register prior the the registration deadline for that election to be eligible to vote.
Political Parties and Designations
When you register to vote you may choose to enroll in a political party or political designation or you may choose to remain unenrolled, which is commonly referred to as independent.
If you choose not to enroll in a party you may still vote in state and federal primaries by choosing a party ballot and will remain unenrolled.
If you choose to enroll in a party you may only vote in that party's primary. The choice to enroll in a party does not affect your right to vote in a general election. All ballots are the same in a general election regardless of party enrollment.
For a list of Current Party's and designations please visit the Secretary of the Commonwealth's Directory of Political Parties and Designations.
Once you make an enrollment decision, you may change your enrollment status by notifying the Fitchburg City Clerk in writing at least 10 day before an election.
Voter Registration Deadlines
The deadline to register to vote, update your registration or change your party is 10 days before any election.
If you became a U.S. Citizen after the voter registration deadline, you can register to vote in person at the Fitchburg City Clerk's Office until 4 pm on the day of the election. Make sure you bring proof that your naturalization ceremony took place after the voter registration deadline.

domain: politics


Coyote Creek Proposed Development Layout
Coyote Creek Development Context Map
Coyote Creek Challenges
Key Community Benefits of Coyote Creek
- 5 acres of new public parkland (20% of site) replaces private pay golf course land
- Network of dedicated public trails promotes healthy lifestyles & sustainable transportation
- 325 homes (townhomes, duplexes, apartments) provide housing diversity & addresses missing middle
- Rental apartment provides housing options for Surrey residents & includes affordable housing (5% of apartment units to be rented at 20% below market)
- Onsite daycare supports Surrey’s families
- Daycare, retail, rejuvenated golf course & clubhouse, and project construction create jobs
- Upgrades to Green Infrastructure Network and local creeks improve ecosystem
- New 77th Ave extension helps relieve local traffic patterns; traffic signal improves road safety
- Community consultation driven redesign includes reduction of density by 61 units, expanded park land, increased green buffer for neighbours, reduced apartment height (5 storeys to 4)
Overcapacity at local schools: help is on the way with $13 million earmarked to add 365 seats in Fleetwood schools
Traffic: 77th Ave extension reroutes 30% of Fleetwood Enclave traffic from passing Sequoia Ridge Community. Development adds estimated 184 trips/hr (AM Peak); 237 trips/hr (PM Peak).
Key Coyote Creek Proposal Information:
Anthem is proposing a diverse range of Coyote Creek housing options including duplexes, townhomes, and apartments. With a floor area ratio (FAR) of approximately 0.59, the proposed density aligns with many of the current single family neighborhoods in the area. For example, the Sequoia Ridge development has a current FAR of 0.50. Furthermore, the SurreyCares Community Foundation’s Vital Signs report (click here to access the reports) indicates that a lack of housing choices has caused a huge challenge for the city, severely impacting a wide swath of the community.
The proposal for Coyote Creek includes:
Two-storey, four-bedroom homes offering park front living. Coyote Creek Duplex Homes are approximately 1,650 – 1,700 sq.ft. with an attached 2 car garage and private backyard.
The three-level Coyote Creek townhomes come in a mix of 2, 3, and 4-bedroom varieties, ranging from approx. 1,200 sq.ft. – 1,700 sq.ft. with attached one and two-car garages.
60 Rental Apartments
A four-storey mixed-use rental apartment building will be the gateway to Coyote Creek. 5% of the rental units will be affordable units to be rented at 20% below market rates. 1 and 2-bedroom homes will range from approximately 550 sq.ft. to 950 sq.ft., with generous private balconies and patios and secure underground parking.
Anthem is working with independent professional consultants Diamond Head Consulting, Phoenix Environmental, and Envirowest to conduct environmental assessments and produce a biophysical analysis of the Coyote Creek site.
Subsequently, the proposal by Anthem includes the following environmental designs:
- 30 m setbacks on both banks of Bear and Sequoia Creeks (City of Surrey policy: 15 m), measured from Top of Bank;
- 25 m setback on Lower Coyote Creek, and 7 m on Upper Coyote Creek;
- Enhancing Lower Coyote Creek to a Class A(O) waterway, allowing it to be a fish-bearing creek for most of the year;
- Removing industrial chemical application from 24 acres of golf lands;
- Dedicating 20% (5 acres) of lands to the City as public park land in perpetuity;
- Cataloguing and identifying existing trees on site to ensure healthy and high value trees are retained, and providing significant new mature planting.
- Calculating critical root zones for retained trees to prevent damage during construction;
- Expanding Sequoia Ridge Parkway to a variable width of between 59 ft to 108 ft.
- Expanding and improving the safe movement of wildlife through the Green Infrastructure Network (GIN).
Supporting Local Business
Through the redevelopment, Anthem will be adding 4,000 sq.ft. of new, neighbourhood serving retail and services in the area. 50% (2,000 sq.ft.) of the retail space has been earmarked for a daycare with its own private outdoor space. It is projected that some 10-15 new jobs would be created as a result of the new daycare and other retail uses.
The proceeds from the land sale will allow Eaglequest Golf to reinvest $2.5 million in their golf course and facilities. This reinvestment will also allow the golf course to retain their current staff and add up to an additional 25 new employees to help better serve the redesigned course and clubhouse. During the proposed development’s 3-year construction phase, further job creation is anticipated with 100-150 new full-time construction jobs onsite.
Accessibility and Permeability
The site at present is a privately-owned golf course which requires users to pay for access to the greens. If approved, the proposal by Anthem will add 5 acres of public park space and greenways to the community, and will connect Fleetwood Enclave with 152 St via a light controlled intersection with the proposed 77 Ave connector.
Other ways Anthem is seeking to improve accessibility and permeability include:
- Improving the Sequoia Ridge Pathway to allow better pedestrian and cyclist experience;
- Adding a right in, right out entryway at 77 Ave instead of 80 Ave which extends through to Fleetwood Enclave;
- Aligning sightlines for better view corridors and community safety as per Crime Prevention Through Environmental Design (CPTED) principles;
- Promoting alternative modes of transportation through multi-use pathways along 152 St and 77 Ave;
- Preparing the neighbourhood for connection with the upcoming LRT station through a sheltered bus stop close to the intersection of 152 St and 77 Ave;
Frequently Asked Questions
While the southern portion of Eaglequest golf course falls within the ALR, the portion which Anthem is proposing to redevelop does not.
This site is neither public nor parkland, it is a private golf course. The City of Surrey does not include private green space as park land, and as such, the City has zoned this 24-acre parcel for suburban development. This zoning would restrict Anthem to building large lot single-family homes. Anthem is seeking to change the zoning to allow for a variety of housing options, and to support increased park land dedication, and the proposal will be subject to the City’s development approval process.
This proposal has been developed with the intention of providing a positive contribution to the City’s 5 Planning Challenges as identified by the City of Surrey’s 2013 Official Community Plan (OCP). The below lists the 5 Planning Challenges found in the City of Surrey’s 2013 OCP (click here to access the OCP in full; the 5 Planning Challenges are from pages 20-25) and how the proposed development intends to address these challenges:
- Accommodate continued population growth by proposing a compact, pedestrian-friendly neighbourhood that “maximizes the efficient use of urban land in order to accommodate the approximately 2% [growth in population] per year over the next three decades” (OCP,2013).
- Match population growth with business development and employment opportunities by reinvesting into the golf course, providing a redesigned course and upgraded facilities which may see up to 25% increase in employment at Eaglequest Surrey.
- Reduce reliance on the private automobile with a new network of trails and multi-use pathways, including the greenways along the 77 Ave Extension and 152 St. The overall layout of the proposed redevelopment emphasizes walking and cycling, connecting residents to Fleetwood’s park lands.
- Ensure a resilient city in response to rising energy costs and changing climate with a “compact urban form which reduces the required extension of infrastructure” (OCP, 2013) and its sensitivity to existing creeks and high-value trees, the proposed plan seeks to create a more complete, sustainable neighbourhood.
- Serve the increasingly diverse needs of Surrey’s population by proposing a variety of housing types including duplexes, townhomes, and apartments, creating opportunities for young families and seniors who “require new forms of housing…in order to allow them to remain in their neighbourhoods” (OCP,2013).
Anthem is working with the Planning and Engineering Departments at the City of Surrey and, through City staff, with Translink, to determine the best way to manage any potential traffic concerns. Their input and recommendations guide the design of roadways within the development, and as a result, Anthem is proposing:
- A new connection between 154 St and 152 St, as envisioned in the Fleetwood Enclave Infill Plan, through an extension of 77 Ave. The intersection between 152 St and 77 Ave will include a new traffic light to regulate local traffic patterns;
- A sheltered bus stop at 152 St and 77 Ave will provide easy transit access and connectivity for the neighbourhood;
- Approximately 4,916 feet of new pathways and connections, designed with cyclists and pedestrian connectivity in mind, with the intention of creating an environment promoting alternative transportation modes.
Anthem has also retained the services of Bunt & Associates, a professional transportation engineering company, and consulted with a cycling advocacy group to ensure the adoption of appropriate cyclist friendly design in the proposal.
As a part of redevelopment, Anthem will contribute a School Site Acquisition Charge which directly contributes to the future purchase of land for schools in the City of Surrey. Anthem has also met informally with the Surrey Board of Education to identify and better understand the circumstances of the local schools in the catchment area. Surrey is a fast-growing municipality, and as a result, the vast majority of its schools could benefit from expansion and additional seats. As part of the 2018-2019 5-year capital plan, two schools in the Fleetwood area, including William Watson Elementary in the immediate catchments area, have been earmarked to receive significant upgrades totaling a shared $13 million towards the creation of 365 new seats. As the Provincial Governments works towards its commitment to providing hundreds of millions of dollars to school upgrades, the School District can use additional tools, such as the adjustment of school catchment boundaries, to mitigate capacity issues and help better distribute school populations during periods of growth.
We also would note that it would be several years before any new residents would be moving into our proposed development, allowing the School Board further time to continue with their ambitious capital program.
Yes, Anthem has met with many local community stakeholders, including the strata councils of the Sequoia Ridge gated community to the east, two private meetings with its residents, users of the golf course, as well as several local non-profits. Anthem also held a Public Information Meeting open to the general public on May 24th, 2017. Anthem has since made the following changes in response to community input:
- Removed 61 units (16%) to reduce density of development;
- Reduced the height of apartment building from 5 to 4 storeys;
- Converted the apartment building to rental housing;
- Replaced second apartment building with townhomes and amenity building;
- Added more retail;
- Included 2,000 sq.ft. of daycare space with a dedicated outdoor play space;
- Improved road alignments to maximize views through the site;
- Included feedback for cyclist friendly design guidelines throughout the site;
- Enhanced privacy with a new fence between the Sequoia Ridge Parkway and neighbours with gated access between the new park and strata homes;
- Increased park dedication to 21%;
- Retained and enhanced existing golf pond;
- Created a new landscaped strata park with retained views to the west; and
- Doubled the Sequoia Creek setbacks to 30m.
We are currently awaiting the final stages of the municipal review process, and are hopeful that we will be at a Public Hearing in early 2018.
We are expecting an approximate 36-month buildout following final municipal approval.
The golf course at Coyote Creek is wholly owned and operated by Eagle Quest Golf. Should Anthem’s redevelopment proposal receive Council approval, Eagle Quest Golf has committed themselves to reinvesting the funds from the land sale into redesigning the golf course, as well as the club house and its associated amenities.
On January 22, the City of Surrey Council forwarded Anthem’s application for 7778, 7858, and 7902 152 Street for a Public Hearing on February 5. Please see https://surrey.ca/city-government/3059.aspx for up-to-date information on the Public Hearing.
Stay Informed About Coyote Creek
Anthem has submitted an application to the City of Surrey to amend the Official Community Plan and rezone/redevelop 7778, 7858 and 7902 152 Street. The proposed development site encompasses the portion of Eaglequest Golf Course that is located outside the boundaries of the Agricultural Land Reserve. The proposal includes a mixture of duplexes, townhomes, market rental apartments, neighbourhood serving retail and green space.
The proposed development site surrounds the Fortis Gas Works facility and is framed by 152 Street to the west, Sequoia Ridge Park to the north, existing Sequoia Ridge homes to the east, and the Eaglequest Golf Course to the south.


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|200-year-old Bowhead whales! (World's longest-living animals)|
Author: Atlantic, Leonard
An introduction to bowhead whales, including where they live, what they eat, their unique features, and more.
|Accelerated Reader Information:|
Interest Level: LG
Reading Level: 3.50
Points: .5 Quiz: 188697
School Library Journal (04/01/17)
Full Text Reviews:
School Library Journal - 04/01/2017 Gr 3–5—The animals featured in this set share the common quality of longevity, though more general information, including physical characteristics, life cycles, and behavior, make up the majority of the content. Three or four sentences per page provide basic facts, with easy-to-follow sentences opposite attractive full-page photographs. Descriptions of how scientists determine ages aren't always included (in Red Sea Urchins readers are informed about when scientists learned the maximum age, but not how), though the facts about the unusually long life spans are generally intriguing. For instance, students will discover that elephants typically live longer in zoos than in the wild, and that a harpoon tip can pinpoint a whale's age. The four titles about land dwellers feature examples of specific creatures, such as a movie star parrot, lending extra appeal. Each book ends with a brief note about threats to survival. VERDICT Solid species treatments with an eye-catching hook that is sure to attract browsers. - Copyright 2017 Publishers Weekly, Library Journal and/or School Library Journal used with permission.

domain: biology


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Harvey Weinstein was moved to New York City’s Rikers Island prison after having heart surgery for putting a heart stent. The ex-movie mogul was arrested on February 24 for third-degree rape and criminal sexual assault, and has since been in Bellevue Hospital.
After the trial, the 67-year-old complained of chest pains and was taken to hospital where he had a stent implant to remove a blockage, a spokesperson said.
A source close to him confirmed to DailyMail.com on Thursday that he underwent a four-hour surgery on Wednesday night to have the stent put in before departing for North Infirmary Command, which is for high profile inmates and inmates with health issues.
An ambulance believed to be carrying Weinstein was later pictured pulling up at the prison with its emergency lights on.
Mr.Weinstein was cleared of the most serious counts of predatory sexual assault and first-degree rape but was found guilty of raping actress Jessica Mann in 2013 and forcibly performing oral sex on production assistant Mimi Haleyi in 2006.
He now faces up to 25 years in prison for the convictions relating to two women.
More than 80 women have accused Weinstein of sexual misconduct, but only two have had their claims prosecuted. The ex-movie mogul is also still awaiting a case in Los Angeles.


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The International Finance Corporation (IFC), part of the World Bank, is considering participating in a $180 million financing for the Vietnamese animal and aqua feed producer Greenfeed Vietnam Corporation.
The project will be funded by 1 trillion ($43 million) worth of IFC bonds, with a maturity of up to seven years, $75 million in bank borrowings, and $62 million equity and/or internal cash generation, IFC said in an investment proposal.
Founded in 2003, GreenFeed has integrated operations across the pork value chain, from feed production, pig breeding, and commercial pig farming to pig slaughtering, and pork processing.
IFC said its proposed financing will support the expansion of GreenFeed’s commercial pig farming capacity and some maintenance of GreenFeed’s feed mills in Vietnam.
While being mainly operated in Vietnam, the company also has feed production operations in Cambodia, Laos, and Myanmar. IFC said GreenFeed is currently the fifth-largest feed producer in Vietnam and among the largest locally built integrated players.
GreenFeed’s major shareholders are Oriental Ford Holding and Quang Dung Trading Co Ltd, according to IFC. Oriental Ford is a Hong Kong-domiciled business, and Quang Dung is also an animal feed company, which are both linked to GreenFeed’s chairman Ly Anh Dung, according to DealStreetAsia’s research.
Prior to the financing proposal for GreenFeed, IFC has backed millions of US dollars in the Vietnamese livestock industry, including investments in poultry firm Bel Ga and veterinary medicine business Anova Corp.
IFC’s other investments in the sector include Guangxi Yangxiang, Shenzen Alpha Feed, and Muyuan Foods in China, and India’s Suguna Group.

domain: food


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Simplicity meets vintage industrial in this clean design. A tribute to the heritage and history of both Fayettechill (est. 2009) & the Ozark Mountain Family (est. 1946), this typographic centric design was created by artist, Taylor Morgan.
- Short Sleeve Unisex Tee
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- Made in the U.S.A.
- Smokehouse Blend - Preshrunk 50% Organic Cotton / 50% Recycled Polyester, Weight 4.2 oz
- Nature USA
- Taylor Morgan - Fayetteville, Arkansas
Shipping & Returns
Does your Fayettechill gear not fit? Need a different size or color?
We will be glad to exchange or refund your items within 30 days of delivery.
Items must be in unworn, unwashed condition with original tags attached.


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A Phase 1 study has started dosing patients who have newly diagnosed high-grade gliomas with a combination of Candel Therapeutics‘ gene-mediated cytotoxic immunotherapy (GMCI) plus Opdivo (nivolumab) and standard of care therapy.
GMCI (aglatimagene besadenovec plus prodrug) is an “off-the-shelf” adenovirus-based medicine meant to increase the amount of immune cells entering a tumor, improving immune cell responses and making patients more likely to respond to immunotherapies. This is particularly important for brain tumors such as gliomas, which have a very immunosuppressive environment.
The treatment delivers a gene of the herpex simplex virus into cancer cells, which can be used to create toxic compounds that cause localized cancer cell death. Cancer cells then shed small protein fragments able to stimulate an immune response and to trigger immune cell migration into tumors.
Combining GCMI with standard of care therapies, including surgery, radiation therapy, and chemotherapy, has shown a good safety profile in multiple tumor types, with promising signs of efficacy.
In glioblastoma — the most aggressive kind of brain cancer — a combination of GCMI and standard of care was well-tolerated and extended patients’ survival from a median of 16.3 months to 25.1 months in a Phase 2a study (NCT00589875). In another trial (NCT00634231), the treatment was also deemed safe in children and adolescents with brain cancers.
“The data generated with GMCI in the upfront high-grade glioma setting is some of the more compelling clinical data in the field in the last few years. The scientific rationale for the combination of GMCI and nivolumab is sound and is supported by pre-clinical data,” said Patrick Wen, director of the Center for Neuro-Oncology at Dana-Farber Cancer Institute, Harvard Medical School.
The trial, in collaboration with the Adult Brain Tumor Consortium and Bristol-Myers, is led by Wen. The researchers expect to include 36 patients across the U.S., all of whom with newly diagnosed high-grade gliomas eligible for surgery.
Participants will receive the CGMI adenoviral vector at the time of surgery — the therapy is delivered into the tumor site — followed by Opdivo and standard radiation therapy plus the chemotherapy temozolomide.
The study’s main objective is to determine the safety and maximum tolerated dose of the combo therapy. Additional objectives include overall survival and the length of time during and after treatment that a patient lives without disease worsening.
“The application of our GMCI platform in combination with nivolumab further expands Candel’s glioma franchise beyond single use application and is an important milestone for the company,” Estuardo Aguilar-Cordova, chairman and CEO of Candel Therapeutics, said in a press release.
“We are excited for the opportunity to work on a potential new treatment for patients with this devastating disease and we are grateful to our collaborators, the patients participating in this study, and their families,” Aguilar-Cordova said.
Added Wen: “When one further considers GMCI’s compelling clinical data in various other indications, there is a strong rationale for moving forward with this combination study.”