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Aerial view of Salerno coastline at sunset, view of the city port and the Amalfi coastline, Salerno, Italy.
- Michele Rinaldi / Amazing Aerial Agency
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Italy, Portugal, Salerno, above, abstract, aerial, amalfi coast, architecture, background, beautiful, bird's eye view, building, buildings, campania, city, culture, drone, european, exterior, forms, fort, heritage, high, historic, home, house, medieval, neighborhood, old, old town, over, overhead, pattern, perspective, residential, roof, rooftop, shapes, stone, suburb, sunset, tourism, town, travel, urban, view
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- "Our DNA functions as an archive. It contains not only genetic instructions passed down from previous generations, but memories as well. The memories of our ancestors."
- ―Warren Vidic, a leading figure in genetic memory, 2012.[src]
Genetic memory is the collection of memories of one's ancestors that are passed down into subsequent generations through DNA. It enables instinctive skills in animals, and acted as an archive of history in humans.
The corporation Abstergo Industries developed the Animus virtual machine explicitly to decode and render such memories in a three-dimensional feed, allowing the reliving of past events and the discovery of hidden information. After extraction, genetic memories could also be reviewed by people who did not hold them, through the use of another Abstergo creation, the Data Dump Scanner.
- Main article: Animus Project
This eventually led to the creation of the Animus Project, headed by Dr. Warren Vidic. The project involved acquiring several human subjects with historically relevant ancestors, particularly those of notable Assassins or Templars, and analyzing their genetic memories. Animus Subjects 1 through 17 were placed into the Animus for extensive review, where large sections of their genetic memories were analyzed.
Genetic memories could be obtained from both willing or unwilling subjects. Should one not co-operate in entering an Animus and reliving a memory, a coma could simply be induced on the subject and the memories extracted from their dormant mind.
However, in regards to this method, William Miles revealed that by being uncooperative and refusing to move, it would make reviewing memories hard enough so that it would take weeks to try and force such information out of an individual.
Even when done voluntarily, initially reliving genetic memories could prove difficult, as most participants subconsciously rejected the foreign memories. Traumatic genetic memories were also difficult to access, at least until the subject had greatly increased their synchronization with their ancestor.
Additionally, genetic memory of one individual stopped upon the conception of the next ancestor, from which the viewer was descended. On the occasion where Altaïr Ibn-La'Ahad and Maria Thorpe conceived their second son, Desmond's ancestral memories shifted from Altaïr to the child.
Memory within memory patterns could also be exhibited, given certain conditions. Subject 15, for example, relived genetic memories while she was pregnant. During this time, the memories decoded by the Animus competed for priority, as the machine attempted to read the memories of both the fetus' mother and father.
A similar case occurred when Desmond viewed the later memories of Ezio Auditore. At one point where he attempted to relive the Siege of Viana, at the time, Ezio himself was recalling the Siege of Monteriggioni, thus forcing Desmond back into that memory.
Synchronizing memories from the 20th century proved challenging for Abstergo Entertainment, as reliving someone driving for lengthy periods of time led to researchers experiencing the same semi-catatonic state people enter when driving in real life, rendering progression more difficult.
- Main article: Memory extraction
By the early 21st century, Abstergo had found a way to extract memories from the genetic memory of certain individuals and to let other subjects relive those memories using the Data Dump Scanner software.
Memory extraction served as the basis for Abstergo's Project Legacy, which focused on obtaining information on the Assassins and the Pieces of Eden though extracted memories, and the Animi Training Program, which used extracted memories as a means to train Abstergo's agents. Extracted memories were also later inserted into the privatized Animi sold by Abstergo Entertainment.

domain: psychology


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First, the purchase – it’s of a popular tourist attraction, arguably Hollywood’s most visible landmark people can legally set foot on (so you know we’re not referring to the “HOLLYWOOD” sign).
It’s Grauman’s Chinese Theater on Hollywood Boulevard, which celebrated its 80th birthday this past May. And “set foot on” was an intentional pun; the footprints, handprints, etc., in cement are the theater’s trademark (in addition to its distinctive architecture evoking the Far East).
The purchaser knows the area well. It’s CIM Group of Los Angeles, the area’s largest commercial landlord, which owns most of the real estate on the north side of Hollywood Boulevard between Highland and Sycamore avenues.
The theater will continue showing movies under a contract with Mann Theatres.
Sid Grauman, a Los Angeles movie theater impresario, had previously built two palaces, the Million Dollar Theater in downtown and the Egyptian Theater elsewhere in Hollywood, but he wanted the Chinese to be his crowning achievement. Many of the theater’s artifacts came directly from China, and it was appropriate that Chinese-American actress Anna May Wong drove the first rivet in the steel girders when construction began in January 1926. (Incidentally, Grauman never owned the theater outright, having at most a one-third share.)
Over the years, many stars have put their hands or feet into a block of cement in the theater’s courtyard, such as Judy Garland, shown below with Mickey Rooney at the October 1939 premiere of “Babes In Arms.”
Carole Lombard never got a similar opportunity, though the chances are good she would have had the chance had she lived longer.
Did any of Lombard’s films play at the Chinese? Carole Sampeck of The Lombard Archive, who’s forgotten more about Lombard than most of us would remember, “is pretty certain” – but not 100 percent – that “Twentieth Century” ran there in 1934, and that “My Man Godfrey” and “True Confession” might have done likewise. Unfortunately, there’s no place online listing all the films that have played at that historic theater.
In contrast to the Chinese, another landmark moviehouse – the Stanford Theatre in Palo Alto, Calif., whose schedule is exclusively classic fare – has a listing on its Web site of all the films that ran there from 1929 to 1961: http://www.stanfordtheatre.org/stf/aboutHistory.html. Below are the Stanford’s exterior and interior.
The schedules are fascinating; for example, we learn that “Show Folks,” a part-talkie with Lombard in a supporting role, ran there on Feb. 16, 1929…not to be confused with the Marion Davies classic “Show People,” which appeared there that Jan. 2. (The Stanford also periodically runs festivals; let us hope they schedule one for the centennial of Lombard’s birth in October 2008.)
The other real estate news in Hollywood concerns a site on Sunset Boulevard now better known for television than movies. It’s officially known as “Tribune Studios,” home of KTLA television, the first TV station in Los Angeles, going on the air in January 1947.
But for Hollywood history buffs, its claim to fame rests with Warner Brothers, which built the lot in 1919. Many of its pictures over its first decade were shot there, including the popular Rin-Tin-Tin films, “Don Juan,” the first film with a prerecorded orchestral soundtrack, and “The Jazz Singer,” the first feature film with talking sequences. However, Warners moved most of its feature film production to a larger lot in Burbank after its purchase of First National in 1928.
After ’28, the studio’s chief ties to Warners was its animation unit. This was the home of the famous “Termite Terrace,” where Porky Pig, Bugs Bunny, Daffy Duck and other classic cartoon characters came to life. Cartoon production was shut down in the early fifties for fear of rising costs if 3-D caught on; it didn’t, and when the animation division was revived in 1955, it did so at new offices at the main Warners complex in Burbank. (So the “Animaniacs” characters Wakko, Yakko and Dot -- left to right, below -- haven’t lived in the “WB” water tower all that long...unless there was also one in Hollywood.)
The Sunset lot – part of which was converted into a 52-lane bowling alley -- became a rental unit during the television age, hosting everything from a few seasons of “Gunsmoke” to the debut season of “WKRP in Cincinnati.”
So what ties does the lot have with Lombard? Not much, in all honesty. It’s possible she went to see John Barrymore, a Warners contract player, on the lot when she auditioned to play opposite him in “Tempest” (not the Shakespeare play) although it was a United Artists production. She won the part, but never got to play it because of her automobile accident. And after her recovery, she may well have visited Warners, looking for work.
As for the future of the lot, Mark Evanier, who has a splendid blog, “News From Me,” is a bit skeptical whether it will remain a full-fledged TV production facility, fearing it could be converted into something else: http://www.newsfromme.com/archives/2007_08_30.html. People had similar fears a few months ago when the old Columbia lot on Gower Street was sold. We’ll ultimately have to see how both cases turn out.

domain: entertainment


I remember really liking the 2000 TV series, Dark Angel. This show introduced Jessica Alba who has gone on to do many movie roles.
The complicated premise is that America is damaged by EMP, leading to a financial collapse. Children genetically altered to be supersoldiers escape a secret lab in Washington state. One of them survives to grow up in Seattle and teams up with an underground resistance movement to fight corruption and evil. She is being hunted by government actors who would like to get their supersoldiers back.
The show was fairly successful.
I tried to rewatch the pilot. The problem with many older shows, especially cheaply made ones, is that they are full of cliched and stereotyped characters. There are also a bunch of mediocre fight scenes and stunts. I might have thought that this was good 21 years ago, but it seems not very good now.
I might try more episodes, but I am not optimistic.


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Congress on verge of extinction in India: Badal
Chandigarh: Shiromani Akali Dal president Sukhbir Singh Badal on Monday said the Congress was on the verge of extinction in the country and its leaders, especially in Punjab, were leaving the party.
Addressing rallies in Moga assembly constituency for the Feb 23 by-election, Badal said the Akali Dal "was flooded with requests from Congress leaders wanting to join the party".
"The Congress is on the verge of extinction in India and in Punjab, there is complete demoralisation within the party. Senior Congressmen are scared that their party will never come back to power," he said.
Forecasting the disappearance of the Congress from the political map of India after the 2014 Lok Sabha polls, Badal said the people of the country were tired of inflation and scams.
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- Ex-Army officers threaten to return JNU degrees against 'anti-national' activities in campus
- Really? Is this why Deepika Padukone not open about her alleged relationship with Ranveer Singh?
- JNU protest: Kejriwal hits out at PM Modi, says targetting innocents will prove costly to him

domain: news


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Title: The Effect of Urban Sprawls on Timber Harvesting
Author: Barlow, Stephen A.; Munn, Ian A; Cleaves, David A.; Evans, David L.;
Source: Journal of Forestry, December 1998, Vol. 96, No. 12, pgs. 10-14
Publication Series: Miscellaneous Publication
Description: In Mississippi and Alabama, urban population growth is pushing development into rural areas. To study the impact of urbanization on timber harvesting, census and forest inventory data were combined in a geographic information system, and a logistic regression model was used to estimate the relationship between several variables and harvest probabilities. Although proximity to good roads increases the likelihood of harvesting,almost all measures of urbanization--but particularly proximity to development and higher population density--lead to lower harvesting rates. Further, reductions in normal silvicultural harvests outweigh the increases in conversion harvests and lead to a short-run decrease in supply.
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Barlow, Stephen A.; Munn, Ian A; Cleaves, David A.; Evans, David L. 1998. The Effect of Urban Sprawls on Timber Harvesting. Journal of Forestry, December 1998, Vol. 96, No. 12, pgs. 10-14
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domain: geography


One of today’s most likeable and bankable action stars — Dwayne Johnson — aims to set the box office afire again with “Skyscraper.”
From the trailer, this looks like it might be the offspring of a “Die Hard” and “The Towering Inferno” union. Johnson latest finds the muscled one playing a war veteran tapped to be the security expert at a ginormous skyscraper called The Pearl. When a fire breaks out, the action heats up. Let’s hope it’s Rock solid.
For the younger set begging for more animated hijinks after seeing “The Incredibles 2,” there’s another sequel that might keep ‘em entertained. In “Hotel Transylvania 3: Summer Vacation,” Drac and his ghoulish chums are kickin’ it on a cruise, but that bit of much-need R&R slams into stormy weather due to the captain.
Tired of breezy summer entertainment? Three indies offer something different.
Filmmaker Bruce LaBruce continues to push buttons and boundaries with “The Misandrists,” a quirky, raunchy and wild creation about an injured guy who’s given shelter secretively in the home where the Female Liberation Army organizes. It’s not for all tastes and is not rated for a reason, but I couldn’t stop watching, until one bloody scene made me turn away.
My gotta-see picks of this rather meager week include two international releases festooned around circumstances that spiral out of control.
Picks of the week
“Under the Tree” is a full-bore satire that takes a jaundiced, stinging view of human nature. What begins as a feud between neighbors over a tree somersaults into more ugly situations as suspicions and retaliations pile up. Oh, and there’s also the volatile fallout when a wife finds her husband watching a sex tape of himself with another woman. Hafsteinn Gunnar Sigurdsson directs and writes with a fire in his belly. It was Iceland’s Oscar entry for best foreign language film and is the antithesis of a chipper summer movie. It’s one intense, well-made, well-acted film.
“Ava,” opening at the Roxie in San Francisco, is quite a find, fully immersing audiences into the stifyling, suffocating reality of a rebellious 17-year-old Iranian girl (an excellent Mahour Jabbari) who’s ostracized over a bet about a boy. Sadaf Foroughi has made a striking feature film debut, an uncomfortable drama set in Tehran that expertly uses evocative visuals and camera shots to further express the chokehold that Ava experiences due to the actions of family, friends and teachers. Worth a trip to S.F. to see on the big screen.
Randy Myers is a freelance correspondent covering film and is the president of the San Francisco Film Critics Circle.


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Sterile processing departments (SPD) play a vital role in preventing hospital acquired infections (HAI) and contributing to the overall clinical and operational performance of healthcare systems.
The Verrix Solution
Verrix is leveraging cutting edge innovation to develop a new sterilization monitoring platform designed to give SPD staff the highest level of confidence in their results.


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Kendall Jenner spoke with massive sister Kourtney Kardashian for her new venture, Poosh! Kendall opened up about falling in love.
Kendall Jenner, 23, had a dialogue with Kourtney Kardashian, 40, on Poosh, through which the younger mannequin talked about her passions in life. Kendall associated her love of horses and modeling – which she had a sense in her that was “simple” – to falling in love. “I’m very a lot somebody who, I fall in love with somebody – I’m like love-at-first-sight kind of individual,” Kendall stated. “I do know I’m gonna fall in love with you the second that I meet you.”
“I’ve this overwhelming feeling,” Kendall continued, whereas she and Kourt ate salads and tea from household fave Well being Nut. “And that doesn’t occur lots for me. I’m not the sort of one who can, like, progressively fall in love with somebody. I don’t understand how that’s alleged to go. I don’t perceive that.”
“So I feel it’s the identical factor for me, with like, sort of figuring out what I like need to do or what I like,” she added. “I’m a extremely simple individual in the case of that.” However Kendall additionally admitted there are occasions when she’s uncertain or there isn’t readability in sure conditions. “I might by no means say that I at all times have it collectively. Or I at all times know what’s happening.”
Kendall continued, “I’m going by means of moments of, like, not figuring out and being uncertain. And like what do I need to do subsequent? About life, about work typically. I feel everybody goes by means of these moments.” We expect you’re doing fairly nice Kendall – the younger star has walked the runway for big-name manufacturers like Alexander Wang, Donna Karan, Vera Wang, Michael Kors, Marc Jacobs, and extra. She can be on the household actuality tv present, Preserving Up with the Kardashians, and has a partnership with pimples model Proactiv, too. We’re rooting for you, Kendall!


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VC signals change of guard at directorate of physical education & sports
INDORE: Devi Ahilya Vishwavidyalaya (DAVV) vicechancellor Dr Narendra Dhakad on Tuesday signalled at withdrawing Ajay Kumar as director of Directorate of Physical Education and Sports after Kumar and School of Physical Education head Prof Deepak Mehta entered into a feud over use of playing grounds on UTD campus.
“I don’t want university staff to indulge in unnecessary fights. I have come across an issue between Kumar and Mehta. I talked to the duo and soon took a decision in the matter,” Dr Dhakad said. He signalled that, if need be, Kumar would be removed from directorship.
Sources said that the VC is contemplating replacing Kumar with Dr Sunil Dudhale. Kumar and Mehta came face to face after Kumar wrote a letter to the VC alleging that Mehta was trying to take control of playgrounds of the UTD campus.
In a letter to the VC, Mehta rubbished the allegations and lodged a counter complaint against Kumar. The VC held talks with the duo to resolve their dispute but to no avail, sources said. As truce could not be reached between the duo, according to the sources, the VC decided to remove Kumar from director’s post.
“Prof SK Yadav staked claim on the directorship but the VC rejected his claim,” sources said adding that the VC is not happy with Yadav as he had lodged a complaint with Raj Bhawan against School of Yoga head SS Sharma. He also denied giving directorship to any teacher of School of Physical Education, the sources went on to add.


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St Albans dog owner ordered to muzzle pet after attack on woman
- Credit: Archant
A man from St Albans, whose Alsatian mounted another dog and attacked the owner, has been ordered to muzzle his dog and pay compensation.
Luigi Spasiano, 46, of Nelson Avenue, St Albans, pleaded guilty to being the owner of a dog which was dangerously out of control and was ordered to pay a total of £380 after his three-year-old dog, Jack, escaped from a back garden near Cell Barnes Lane.
The court heard how Jack then tried to mount a bull terrier belonging to Anesta Edge.
Alan Bordis-Smith, prosecuting, said: “The dog tried to mount [Anesta’s] dog. She tried to get her dog away by lifting it - that didn’t work. Jack then bit her to the thigh.
“It broke the skin, requiring hospital treatment. She was quite panicked and felt quite a lot of pain in her leg.”
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The court heard how Spasiano, who required an Italian translator in court, arrived at the scene moments after Jack had attacked Ms Edge.
Mr Bordis-Smith said: “[Spasiano] approached and knew something bad had happened.”
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Jack had never attacked anyone or shown any sign of aggression up until that point, according to police interviews read out in court.
Elizabeth Rebello, defending, explained that Spasiano had pleaded guilty to the offence at the first available opportunity.
She said: “He accepts that the dog was out of control and accepts full responsibility for it.
“But he does describe the dog as a tranquil and placid dog, which has been part of the family for three years, since its birth.
“The dog lives with three children aged eight, 10 and 16 and has had no previous incidents like this.”
In closing, the magistrates said that it was likely a “one off incident” and did not think it was appropriate to have the dog put down.
They did, however, concede that Jack had been “out of control, albeit briefly” and told Spasiano that he must keep the dog muzzled and on a lead whenever it was in a public place.
Spasiano was ordered to pay £100 compensation to Ms Edge, a £180 court charge, a £20 surcharge and £80 in costs.

domain: law


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About the Author
I was an independent bookseller and buyer for 11 years before deciding to take a chance on myself as a novelist. While trying to sell my books, I worked variously as a Publishers Weekly reviewer, a freelance editor, a sort-of librarian, and a window washer. My first novel, The Thin Pink Line, about a woman who fakes an entire pregnancy, was published by Red Dress Ink in 2003 as their own first-ever hardcover. It was published in 11 countries and was the first book from any Harlequin imprint ever to receive a starred Kirkus review. I’ve since had over 20 books published for adults (Vertigo), teens (The Twin’s Daughter) and children (The Sisters 8 series, created with my husband and daughter). Recently, I’ve published a few ebooks as well, including a comedic romance for adults, The Bro-Magnet. I live in Danbury, CT, with my wonderful husband Greg and my equally wonderful daughter Jackie.
ABSOLUTELY LOVED IT
Mercury, named after a football player and the fact that her father loved the color silver, is a successful author. For some reason, her witty, comedic books have struck a chord with chick lit fans. That may be that her books are published by Pink Pet, a known source of all things chick lit. She rants to her agent and high school BFF, Angel, that the New York Time Book Review will have nothing to do with her books, even though they are best sellers and her readers adore them. I immediately thought of Jennifer Weiner and her issue (rightly) that the Times didn’t really cover women authors. Angel also reps Nick, this year’s National Book Award winner. His best friend is Frank, editor in chief of the vaunted NYTBR. Even before Mercury knows who he is , she lays into him with a drunken rant. When she figure out who Frank is, she would like to turn invisible.
In the meantime, her brother, Ralph, has been thrown out by his wife and moves in with Mercury and Nick tags along. Oh and Nick and Frank were college buddies with Ralph. Mercury was never one to shy away from arguing her point, so she sends Frank an offhanded apology, never expecting to her back from the guy. And thus begins an almost stalky type of relationship. She gets it into her head that she must get Frank to read her book and follows him to Florida where he is playing golf with Nick. Ah, and here comes the hot part: a seriously hilarious and hot romance that hits the sheets with strawberries and whip cream. Parts of it were extremely sweet but I couldn’t help but laugh out loud at certain points in this comedy of errors.
Fans of Jane Austen will easily pick up on the wit and and dynamics of these characters and their relationships that are much like Pride and Prejudice. I loathed the fact that all of the men in Mercury’s life had very strong opinions about her books, yet not one had bothered to read one. Mercury definitely has a way with words, even if they are the wrong ones at times. The fact that Baratz-Logsted pointed this out filled me with glee! I adore my chick lit and this one is at the top of my favorites to recommend right now. The dialogue is warm and witty, full of snark and sarcasm and that is really what makes a book stand out for me. If you enjoy Jennifer Weiner or Sophie Kinsella, you are going to really enjoy this one.
This looks great! I remember read The Thin Pink Line quite a while back!

domain: library


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G. Klein1, P. Delmar1, G.A. Kerchner1, C. Hofmann1, D. Abi-Saab1, A. Davis2, N. Voyle2, M. Baudler1,3, P. Fontoura1, R. Doody1,3
1. F. Hoffmann-La Roche Ltd, Basel, Switzerland; 2. Roche Products Ltd, Welwyn Garden City, UK; 3. Genentech Inc., South San Francisco, CA, USA.
Corresponding Authors: Gregory Klein, Biomarkers and Translational Technology, Neuroscience and Rare Diseases, Basel, Switzerland. Email: email@example.com, Phone: (+41) 616820759
J Prev Alz Dis 2021;1(8):3-6
Published online December 3, 2020, http://dx.doi.org/10.14283/jpad.2020.68
Previous findings from the positron emission tomography (PET) substudy of the SCarlet RoAD and Marguerite RoAD open-label extension (OLE) showed gantenerumab doses up to 1200 mg every 4 weeks administered subcutaneously resulted in robust beta-amyloid (Aβ) plaque removal over 24 months in people with prodromal-to-moderate Alzheimer’s disease (AD). In this 36-month update, we demonstrate continued reduction, with mean (standard error) centiloid values at 36 months of -4.3 (7.5), 0.8 (6.7), and 4.7 (8.0) in the SCarlet RoAD (double-blind pooled placebo and active groups), Marguerite RoAD double-blind placebo, and Marguerite RoAD double-blind active groups respectively, representing a change of -57.0 (10.3), -90.3 (9.0), and -74.9 (10.5) centiloids respectively. These results demonstrate that prolonged gantenerumab treatment, at doses up to 1200 mg, reduces amyloid plaque levels below the amyloid positivity threshold. The ongoing GRADUATE Phase III trials will evaluate potential clinical benefits associated with gantenerumab-induced amyloid-lowering in people with early (prodromal-to-mild) AD.
Key words: Gantenerumab, Alzheimer’s disease, positron emission tomography, amyloid.
Alzheimer’s disease (AD) accounts for 60–80% of all cases of dementia globally (1). Currently, the available treatments for AD offer only limited benefits and there is an urgent need for disease-modifying therapies that reverse neuropathologic changes, or slow or stop neurodegeneration (1, 2).
AD pathogenesis is driven by the gradual accumulation of beta-amyloid (Aβ) plaques and neurofibrillary tangles (NFTs) in the brain (1, 3). In vitro and in vivo evidence suggests that soluble Aβ oligomers and insoluble Aβ plaques contribute to cognitive failure by causing neuronal loss, synaptic dysfunction and disconnection syndromes (4, 5). The recognition of Aβ accumulation as the earliest identifiable marker of AD has led to the development of amyloid positron emission tomography (PET), a neuroimaging technique that can be utilized to visualize Aβ accumulation that helps improve diagnostic accuracy and may also facilitate appropriate participant selection in clinical trials (6).
Gantenerumab is a fully humanized, anti-Aβ immunoglobulin (Ig) G1 that binds to Aβ species with high affinity for aggregated forms, including oligomers and plaques, and is thought to remove Aβ via microglia-mediated phagocytosis (7, 8). The long-term, pharmacodynamic effect of gantenerumab-induced Aβ plaque removal in participants with prodromal-to-mild and mild-to-moderate AD is currently being investigated in the PET substudies of the Phase III SCarlet RoAD (SR; NCT01224106) and Marguerite RoAD (MR; NCT02051608) open-label extension (OLE) studies, respectively (7). Interim results showed robust Aβ plaque removal with gantenerumab doses up to
1200 mg administered subcutaneously, with mean amyloid reductions of 59 centiloids and 51% of participants below the Aβ positivity threshold after 24 months (7). Here, we tested whether amyloid signal plateaus or continues to decline with continued therapy in the 36-month results of the ongoing OLE PET substudy.
Participants and study design
Complete details of the study designs and methodologies of SR and MR, the associated OLE studies, and the OLE PET substudies have been previously reported (7-9). Briefly, participants in the SR trial who received double-blind treatment and had ≥1 follow-up visit and those who were currently enrolled in the MR trial were eligible for participation in the OLE. Various titration schemes were used to allow OLE participants to gradually reach the target dose of gantenerumab 1200 mg per month while decreasing the risk of amyloid-related imaging abnormality (ARIA)-related adverse events. The target gantenerumab dose was reached within 6 to 10 months for SR OLE participants, and 2 to 6 months in MR OLE participants.
Participants of the OLE substudy were divided into three cohorts based on their prior exposure to gantenerumab and their stage of AD. The SR cohort included SR participants with all SR treatment arms pooled together (received gantenerumab 105 mg or 225 mg or placebo every 4 weeks during the double-blind phase), all participants in the SR cohort were off treatment for 16 to 19 months prior to OLE higher dosing. The MR double-blind placebo cohort (MR-DBP) included participants in the MR trial who received placebo during the double-blind phase and the MR double-blind active cohort (MR-DBA) included participants of the MR trial who received either 105 or 225 mg gantenerumab during the double-blind phase.
Amyloid-β plaque PET imaging and quantification
Amyloid PET scans were obtained at baseline and at 12, 24, and 36 months after baseline using intravenous
370 MBq 18F-florbetapir, with each 15-minute scan obtained 50 minutes after 18F-florbetapir injection. Participants who received a PET scan during the double-blind phase, within 9 to 12 months of OLE dosing, were not scanned at OLE baseline to minimize participant burden.
Volume-weighted, gray matter-masked standard uptake value ratios (SUVR) were calculated for six bilateral cortical regions using the Automated Anatomical Labeling (AAL) template, normalized by a cerebellar cortex reference region (10, 11). SUVR values were then converted to centiloid values as previously described, using the following linear transformation: Centiloid = SUVR*184.12 – 233.72 (7, 12). The threshold for amyloid positivity has been previously established as 24 centiloids, which corresponds to 1.40 SUVR units. The amyloid positivity threshold represents the quantitative threshold that best discriminates pathologically verified absence of plaques or sparse plaques from moderate-to-frequent plaques (13).
This analysis included all study participants who had a PET scan at OLE baseline (or 9–12 months prior to OLE dosing) and received ≥1 follow-up scan. PET centiloid values were analyzed using a mixed model for repeated measures (MMRM), with treatment visit, treatment group, and the interaction for treatment group by visit as independent variables. An unstructured covariance matrix was used to capture within-participant correlation.
A total of 67 participants with at least 1 post-baseline scan were enrolled in the OLE PET substudy (SR, n = 19; MR-DBP, n = 27; MR-DBA, n = 21). A total of 30 participants completed the 36-month scan (SR, n = 10; MR-DBP, n = 12; MR-DBA, n = 8). The baseline characteristics for both the overall population and the 36-month completers are shown in Table 1. More than half of the participants in each cohort were Apolipoprotein E (APOE) ε4 carriers (SR, 89%; MR-DBP, 67%; MR-DBA, 52%). Across all three cohorts, the mean [SE] baseline amyloid burden in centiloids was above the positivity threshold (SR, 49.6 [12.1]; MR-DBP, 91.1 [9.6]; MR-DBA, 79.6 [10.9]).
APOEε4, Apolipoprotein E; IQR, Interquartile range; MMSE, Mini-Mental State Examination; MR-DBA, Marguerite RoAD double-blind active; MR-DBP, Marguerite RoAD double-blind placebo; OLE, open-label extension; SE, standard error; SD, standard deviation; SR, SCarlet RoAD.
Amyloid PET results
Consistent with our previous report, reductions in mean amyloid burden were observed across cohorts after 12 and 24 months of open-label therapy, with 37% and 52% of participants, respectively, reaching levels below the amyloid positivity threshold (Figure 1) (7). Continued reductions beyond 24 months were observed after 36 months, with mean amyloid levels approaching zero centiloids across all cohorts. The absolute mean (SE) amyloid burden after 36 months were -4.3 (7.5), 0.8 (6.7), and 4.7 (8.0) centiloids for the SR, MR-DBP and MR-DBA cohorts, respectively, representing a change of -57.0 (10.3), -90.3 (9.0), -74.9 (10.5) centiloids respectively. Furthermore, the proportion of participants below the amyloid positivity threshold was 24 of 30 participants (80%) at 36 months (Figure 1).
*LS mean (SE); †Analyzed using an MMRM; LS, least-squares; MMRM, mixed model for repeated measures; MR-DBA, Marguerite RoAD double-blind active; MR-DBP, Marguerite RoAD double-blind placebo; SE, standard error; SR, SCarlet RoAD; SUVR, standard uptake value ratio.
This 36-month OLE PET substudy investigated the effect of gantenerumab on Aβ plaque removal on participants with prodromal-to-moderate AD. Prior results have shown that while the three cohorts began with considerably different mean baseline centiloid values, all three cohorts demonstrated a mean centiloid value just below the amyloid positivity threshold after
24 months of treatment with gantenerumab 1200 mg every 4 weeks. The latest results showed continued Aβ reduction with gantenerumab treatment below the amyloid positivity threshold, without plateau, with 80% of completers below the amyloid positivity threshold after 36 months of open-label therapy. Mean centiloid values of all three cohorts at this time are near a value of zero, which represents the mean amyloid burden expected in a healthy control group (12). Given that the SR and MR-DBA groups may have experienced some amyloid reduction due to low-dose gantenerumab treatment during the double-blind period of the SR and MR studies, the 90-centiloid reduction seen in the MR-DBP group represents the amyloid reduction that could be expected in a treatment-naïve population. The consistent reduction in Aβ suggests that gantenerumab is able to remove Aβ species successfully.
These findings may translate to clinical benefit in people with prodromal-to-mild AD as other studies with aducanumab and lecanemab (BAN2401) have observed amyloid PET reduction as well as clinical efficacy (7, 14, 15). Specifically, in a Phase Ib placebo-controlled study, aducanumab demonstrated reduced brain amyloid plaque levels after 24 months with a reduction in clinical decline as measured by the Clinical Dementia Rating–Sum of Boxes (CDR-SB) and Mini-Mental State Examination (MMSE) (14). In a Phase II placebo-controlled study, lecanemab produced a dose-dependent reduction in amyloid plaque levels after
18 months and a reduction in clinical decline as measured by AD Composite Score (15). In light of these studies, the current PET results suggest that the process of Aβ reduction at the gantenerumab dose of 1200 mg every
4 weeks has the potential to produce clinical benefits. The precise relation between amyloid reduction and clinical benefit is still an open question, including the question of whether a reduction to below amyloid positivity or to centiloid zero makes a difference in the clinical outcome and management of patients with early AD. The ongoing GRADUATE Phase III program evaluates the safety and efficacy of gantenerumab, subcutaneously administered, in participants with early AD. This program includes two global, double-blind, placebo-controlled trials in people with early AD, designed to maximize exposure to gantenerumab and to prospectively examine the correlation between amyloid-lowering and clinical outcomes.
Funding: This study was sponsored by F. Hoffmann-La Roche Ltd, Basel, Switzerland.
Acknowledgments: We would like to thank all the participants and their families, the investigators and site staff, and the entire study team for their time and commitment to the SCarlet RoAD and Marguerite RoAD OLE studies. Medical writing support was provided by Joshua Quartey, BSc, of Health Interactions and was funded by F. Hoffmann-La Roche Ltd.
Conflict of interest disclosures: GK, PD, GAK, CH, DA-S and PF were full-time employees of F. Hoffmann-La Roche Ltd during the conduct of the study. GK, PD, GAK, CH, DA-S, NV and PF are shareholders in F. Hoffmann-La Roche Ltd. AD and NV were full-time employees of Roche Products Ltd during the conduct of the study. AD is currently employed at the MRC Clinical Trials Unit at UCL. MB and RD are full-time employees and shareholders in F. Hoffmann-La Roche Ltd and Genentech Inc. CH has an Alzheimer’s disease-related patent planned which is relevant to this study.
Ethical standards: Institutional Review Boards (IRBs) approved the SCarlet RoAD and Marguertie RoAD studies, and all participants gave informed consent before participating.
Data sharing statement: Qualified researchers may request access to individual patient-level data through the clinical study data request platform: https://vivli. org. Further details on Roche’s criteria for eligible studies are available here: https://vivli.org/members/ourmembers. For further details on Roche’s Global Policy on the Sharing of Clinical Information and how to request access to related clinical study documents, see here: https://www.roche.com/research_and_ development/who_we_are_how_we_work/clinical_trials/our_commitment_to_ data_sharing.htm
Open Access: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits use, duplication, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.
1. Alzheimer’s Association. 2019 Alzheimer’s disease facts and figures. Alzheimers Dement 2019; 15:321-387.
2. Wang S, Mims PN, Roman RJ, et al. Is beta-amyloid accumulation a cause or consequence of Alzheimer’s disease? J Alzheimers Parkinsonism Dement 2016; 1:007.
3. Lee JC, Kim SJ, Hong S, et al. Diagnosis of Alzheimer’s disease utilizing amyloid and tau as fluid biomarkers. Exp Mol Med 2019; 51:1-10.
4. Mucke L & Selkoe D. Neurotoxicity of amyloid β-protein: Synaptic and network dysfunction. Cold Spring Harb Perspect Med 2012; 2:a006338.
5. Delbeuck X, Van der Linden M, Collette F. Alzheimer’s disease as a disconnection syndrome? Neuropsychol Rev 2003; 13:79-92.
6. Ishii K. Amyloid positron emission tomography in the therapeutic strategies for Alzheimer’s disease. Brain Nerve 2017; 69:809-818.
7. Klein G, Delmar P, Voyle N, et al. Gantenerumab reduces amyloid-β plaques in patients with prodromal to moderate Alzheimer’s disease: A PET substudy interim analysis. Alzheimers Res Ther 2019; 11:101.
8. Ostrowitzki S, Lasser RA, Dorflinger E, et al. A phase III randomized trial of gantenerumab in prodromal Alzheimer’s disease. Alzheimers Res Ther 2017; 9:95.
9. Abi-Saab D, Andjelkovic M, Pross N, et al. MRI findings in the open label extension of the Marguerite RoAD study in patients with mild Alzheimer’s disease. J Prev Alz Dis 2017; 4:339 (P336).
10. Fleisher AS, Chen K, Liu X, et al. Using positron emission tomography and florbetapir F18 to image cortical amyloid in patients with mild cognitive impairment or dementia due to Alzheimer disease. Arch Neurol 2011; 68:1404-1411.
11. Barthel H, Gertz HJ, Dresel S, et al. Cerebral amyloid-β PET with florbetaben (18F) in patients with Alzheimer’s disease and healthy controls: A multicentre phase 2 diagnostic study. Lancet Neurol 2011; 10:424-435.
12. Klunk WE, Koeppe RA, Price JC, et al. The Centiloid Project: Standardizing quantitative amyloid plaque estimation by PET. Alzheimers Dement 2015; 11:1-15.e11-14.
13. Navitsky M, Joshi AD, Kennedy I, et al. Standardization of amyloid quantitation with florbetapir standardized uptake value ratios to the Centiloid scale. Alzheimers Dement 2018; 14:1565-1571.
14. von Rosenstiel P, Gheuens S, Chen T, et al. Aducanumab titration dosing regimen: 24-month analysis from PRIME, a randomized, double-blind, placebo-controlled Phase 1b study in patients with prodromal or mild Alzheimer’s disease. Neurology 2018; 90:Abstract S2.003.
15. Swanson C, Zhang Y, Dhadda S, et al. Treatment of early AD subjects with BAN2401, an anti-Aβ protofibril monoclonal antibody, significantly clears amyloid plaque and reduces clinical decline. Alzheimers Dement 2018; 14 (Suppl):P1668. DT-1601-1607.

domain: medical


text:
KeyCorp KEY, +0.55% reported second-quarter earnings, versus a loss in the same period a year ago, that matched consensus analyst expectations, helped by expense controls, decreasing non-performing loans and an increase in revenue. For the quarter ending June, net income was $246 million, or 57 cents a share. A year ago, the banking company lost $160 million, or 38 cents a share, including charges related to discontinued businesses and increased loan-loss reserves. The stock closed Monday down 20 cents at $24.80.
KeyCorp reports Q2 earns that match ests.


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Inconveniently located in neither Wilson’s Creek, Mo., nor Battlefield, Mo., this national park is still more than worthy of a visit. About 15 miles southwest of Springfield, the park is a natural and historical breath of fresh air on a visit to one of the stalest, ugliest cities in the nation, perhaps the world.
Fought on August 10, 1861, Wilson’s Creek was the second major skirmish of the Civil War and the first major battle fought west of the Mississippi River. A bloody mess, the battle was considered a Southern victory, in large part because of the death on the field of Nathaniel Lyon, the first Union general killed in action.
You can easily spend a morning or afternoon here, strolling through the museum with more than 5,000 artifacts and a nice visual recreation, then driving the eight-stop self-guided auto tour.
Other than the Gateway Arch, Wilson’s Creek is the closest destination for St. Louisans who want to celebrate the centennial of the National Park System.


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Most F-1 and J-1 students can travel to Canada, Mexico, and the adjacent Caribbean Islands and re-enter the United States on an expired visa, but only if their stay is less than 30 days.
Can international students now enter Canada?
Effective September 7, foreign nationals who qualify for the fully vaccinated traveller exemption can enter Canada for discretionary travel.
Can I travel to Canada with I 20?
Applications are accepted online or by mail. Citizens of many countries might also be required to provide biometrics (fingerprints and photograph) when applying for a visitor visa to Canada. You must have a valid travel signature on your current I-20 or DS-2019 before you apply for a Canadian visa.
Can F-1 students enter?
In order to activate your F-1 status, students must enter the U.S. The one exception to this one academic year of full-time study in F-1 status is for graduate students whose programs REQUIRE CPT in their first year of study. However, students studying outside the U.S.
Who is exempt from quarantine in Canada?
You may be exempt from the mandatory quarantine requirements under certain conditions, including if you: provide essential services. maintain the flow of essential goods or people. are receiving medical care within 36 hours of entering Canada (non-related to COVID-19)
What happens if you stay longer than 6 months in Canada?
Canada eTA: exceeding your six month limit
If you stay longer than 6 months under the eTA program and your stay has not been extended by Citizenship and Immigration Canada (emergency situations only), you will lose your travel authorization and not be able to use the eTA for future trips.
Can F-1 student go to Canada without visa?
If you plan to visit Canada while you are an international student or scholar at Lewis & Clark, you will need the following: A passport valid for at least six months into the future. … Your US F-1 visa (or J-1 visa for scholars) to permit your return to the US. A Canadian entry visa (where required).
What is proof of ties to Canada?
Proof of your ties to Canada: Your end date on your I-20 (or DS-2019) serve as your proof that you will return to Canada.
Can I visit USA with Canadian PR?
Permanent residents (landed immigrants) of Canada must have a nonimmigrant visa unless the permanent resident is a national of a country that participates in the Visa Waiver Program (VWP), meets the VWP requirements, and is seeking to enter the United States for 90 days or less under that program.
Can you work on an F1 visa?
F-1 students may not work off-campus during the first academic year, but may accept on-campus employment subject to certain conditions and restrictions. After the first academic year, F-1 students may engage in three types of off-campus employment: Curricular Practical Training (CPT)
Do F-1 students need visa to Mexico?
If you are an F-1 or J-1 student traveling to Canada or Mexico, or the Caribbean it’s possible that you do NOT need to obtain a new visa stamp to reenter the U.S. This is referred to as automatic visa re-validation.
Can F-1 students enter U.S. from India?
Travel to the United States from India with a F-1 or M-1 visa may begin no more than 30 days prior to the resumption date of a student’s classes or CPT/OPT program.
Is there a travel ban for Canada?
Vaccinated international travelers may also be allowed to enter Canada beginning September 7, provided the “Covid-19 epidemiology remains favorable,” the Canadian government said in a statement. Entry to Canada remains prohibited for all foreign travelers who are not fully vaccinated.

domain: travel


text: C.M. Rivers grew up reading to the sound of rain on the roof, in the Willamette valley and Cascade mountains of northwest Oregon. He is the author of the poetry collection How To Carry Soup (Homebound Publications), and his poetry has appeared in literary magazines and journals across the United States. He’s spent most of his life wrestling with phobias, and occasionally borrows confidence from his future self. If you’ve nothing better to do (and surely you must have) you can follow C.M. on Goodreads, Amazon, Facebook, or Instagram @dreadpiratebooks.

domain: artistic


text:
Modder UFR has just raised the bar for Starfield mods with a new modification that transforms characters’ eyes to a surprising degree of realism. Apparently he decided that since players would have to spend a lot of time talking to NPCs, their gaze should be as convincing as possible in the virtual world.
Thanks to this mod, the look of Starfield characters now boasts highly detailed textures and reflections that previously often seemed dull or artificial. The mod not only adds life to NPCs’ eyes, but also gives them additional depth, improving the overall experience of interacting with them. UFR appears to have put a lot of effort and skill into creating these textures, working on them by hand.
However, it’s worth noting that even with this level of detail, eyes still can’t fully convey human emotion or make characters’ gazes look completely “alive” – but it’s a big step forward for improving the immersiveness of the game.

domain: design


text:
Time: November 17, 2016 to February 21, 2017
Location: Celeste Network Shop
Event Type: buy, art
Organized By: Celeste Network
Latest Activity: Nov 17, 2016
Export to Outlook or iCal (.ics)
Celeste Network presents its new online Shop, an international gallery with thousands of unique works of art by emerging and mid-career artists.
Since 2007, Celeste Network has promoted the artwork of creative talent worldwide through its international web community. Over the years, the network has given visibility and credibility to hundreds of artworks selected in its prizes and open calls. Juries with renowned international art curators and critics have carefully screened and reviewed works.
Chief-jurors of the caliber of Ellen Blumenstein, Koyo Kouoh, Lorenzo Benedetti, Elena Sorokina, Ami Barak, Katya Garcia-Anton, Eugene Tan, Julia Draganovic, Mark Gisbourne, Adrienne Goehler and Victoria Lu have added recognition to those artworks selected in Celeste.
Artworks by prize finalists and winners as well as many other artworks by emerging artists are now available for purchase in the new Shop, dedicated to all art collectors and art lovers.
Browse Celeste Network’s Shop >> http://www.celesteprize.com/shop/
More info Celeste Network’s Shop,
+39 0577 1521988
Add a Comment
RSVP for Sell and buy with confidence to add comments!


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Smorgasbord Recipes: Smoked Mackerel
- 1 large slice rye bread
- 1/4 oz (7g) soft butter
- 2—3 lettuce leaves
- 2 oz (50 g) curd cheese
- 1 tablespoon single cream
- Pinch each salt, sugar and white pepper
- 1/2 small pear
- 1/2 small banana
- Few drops lemon juice
- 4 oz (100g) smoked mackerel fillet
- Coarsely ground black pepper
- Dill sprig (optional)
- Spread the bread with the butter and top with the lettuce.
- Mix together the curd cheese, cream, salt, sugar and white pepper.
- Wash and core the pear and coarsely grate into the mixture.
- Peel and dice the banana, add to the mixture and sprinkle with lemon juice.
- Stir well and spoon onto the lettuce. Cut the fish fillet into thick slices and arrange in a fan-shape on top.
- Sprinkle with coarsely ground black pepper, and garnish with dill, if used. #COOK’S TIP# You can replace the mackerel fillet with cold roast pork, rolls of smoked tongue or diced smoked ham.

domain: food


A White House under siege. A signature policy initiative turning into an embarrassing public spectacle. Dissent within the president’s own party that threatens to turn into a full-blown revolt.
For Republicans, such a moment came in 2005, as the party faced a daunting midterm election under the shadow of the disastrous Iraq War and a presidency in the dumps. For Democrats, the fear now is that the Affordable Care Act’s clumsy rollout — complete with a botched enrollment website and a debunked presidential pledge that Americans could keep their existing insurance plans — could produce a similar rout at the ballot box, with candidates dragged down by President Barack Obama’s dropping job approval and dimming public perceptions of the law known as Obamacare.
Story Continued Below
On Wednesday, the administration announced that only 106,185 people had selected new health insurance policies through the Obamacare exchanges as of Nov. 2, falling below early White House hopes. And only a quarter of that figure stemmed from the HealthCare.gov website.
It’s utterly premature, Democrats insist, to assume that the ACA will be a millstone around the party’s neck in 2014. But going by the behavior of Democratic lawmakers, it’s plainly not too soon for the party to tackle this dilemma: how to create distance between a set of candidates and a president of the same party whose agenda is on the rocks.
The paradox for any party is this: Standing in lock step with an unpopular leader can only taint candidates in competitive races by association. But if too many candidates flee the president, it serves to amplify his unpopularity, with potentially deeper ramifications for the whole party.
So far, the Democratic approach to all the ACA bungling is to let a thousand Obamacare critics bloom. It’s not that Democratic candidates and officials are openly breaking ranks and calling for the law’s repeal — there’s still solid Democratic consensus that the ACA is mostly a good thing — but politicians across the party have claimed wide maneuvering room for themselves to wander away from the White House line and even directly rebuke the administration.
The political calculus is straightforward, Democrats say. Voters are uncomfortable with the ACA, but private polling shows they are receptive to a “mend it, don’t end it” message. If Democratic House, Senate and gubernatorial candidates can show they want to fix the law proactively, the party believes voters will forgive some bungling by the administration. And if some Democrats are inching away from the president in an awfully public fashion, lawmakers say they have felt little pressure from the White House and other party leaders to make the existing text of the ACA a political hill to fight and die on.
“This is not about loyalty to the White House. It’s about getting the health care law right for the American people,” said Vermont Rep. Peter Welch. “This is a situation where good implementation is good politics.”
Virginia Sen. Tim Kaine, the former Democratic Party chairman, said there’s been “no pushback” on criticism of the HealthCare.gov website or components of the law not viewed as fundamental to health care reform.
“I know many of my colleagues, from the very beginning, feel like if it’s in the reform and improvement discussion, we’re all about it. If all you want to do is talk ‘replace or defund,’ that’s a very easy vote for us,” Kaine said.
Kaine’s fellow Virginian, Rep. Gerry Connolly, said he once drew “fairly mild” pushback from higher-ups on the Hill for some of his ACA criticism, but “that was the end of it.” “We’ve put a lot on the line, politically, and that we have so much at stake over technical glitches is extremely frustrating. Having said that, I think most Democrats don’t want to lose sight of the incredible corpus of reforms the law represents,” Connolly said.
The party’s frustration with the law’s rocky rollout has grown more intense and more public with each passing day: North Carolina Sen. Kay Hagan demanded an investigation this week into the bungled HealthCare.gov website. Democratic Rep. Allyson Schwartz, a candidate for governor of Pennsylvania, has called the ACA’s rocky launch “inexcusable.” Lawmakers have proposed alterations ranging from the modest — repealing the medical device tax — to the more invasive, like Louisiana Sen. Mary Landrieu’s push to let Americans roll over all existing insurance plans into 2013.


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After the success of the Stellina and Vespera smart telescopes, Vaonis introduces its latest innovation: Hestia
Hestia, a smartphone-turned-smart-telescope, has surpassed its funding goal in just two days. With over $500,000 pledged, Hestia is already a hit with astronomy enthusiasts. Hestia allows users to unlock the universe by capturing stunning images of the Sun, the Moon, and deep sky objects. Guided by the Gravity app, users can point out celestial objects using an interactive sky map.
With Hestia, you can:
- Capture the Sun safely
- Observe the upcoming 2024 solar eclipse
- See the Moon in incredible detail
- View deep sky objects like the Orion nebula, the Andromeda galaxy, and the Pleiades.
Reminiscent of the shape and weight of a book, the new Vaonis telescope is based on an optical system consisting of a 30 mm (1.18 in) lens and prisms to collect and focus the light directly into the camera sensor of a smartphone.
Users position their smartphone on the device and align the phone’s camera with Hestia’s eyepiece. The instrument is designed to accommodate all sizes of smartphone thanks to a system of removable magnets. Guided by the Gravity by Vaonis companion app, future astronomers can then point out celestial objects using an interactive sky map and observe the Sun, the Moon and deep sky objects phone screen, including the Orion nebula, the Andromeda galaxy, the Pleiades , and much more.
With Kickstarter prices starting at just $149, Hestia is making smart telescopes even more accessible to people curious about discovering and understanding the sky around them. On 8 April 2024, the eagerly anticipated total solar eclipse will cross the United States from coast to coast. Hestia will be the ideal instrument for a closer and safe look at the eclipse, immortalizing the rarest and most fascinating celestial phenomenon humanity has ever witnessed.
. The Hestia telescope will be available for pre-order on Kickstarter as of July 18, starting $149.
Hopefully we get one in for a full review.


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hidden gem, a bright, energetic cozy space for small-medium size group
classes, team building events, meetings, workshops and production
Fit Toronto specializes in group fitness classes offering a beautiful
space to rent for individuals and instructors wanting to introduce their
own specialized programs and share their passion of art, dance, fitness
and so much more with others. We strive to provide an outlet and
guidance for you to excel and achieve your dreams.


text:
Green Team! (Step into Reading, Step 4) by Christy Webster
Teenage Mutant Ninja Turtles 2012 theme song lyrics
Green with Jealousy
Lifted from the pages of the popular comic series, a wildly successful Saturday morning cartoon, and a massive hit-line of toy action figures, the motion picture adaptation of the beloved crime fighting turtles brought the franchise to the next level. Sourced from the original masters, the complete film music by DuPrez has been re-stored and re-mastered for a deluxe double LP album release. This special release marks the very first time the score has been released in any format. The complete album art was created by Kevin Eastman exclusively for Waxwork Records , and it features his classic comic-book style presented as a sequential storyline of the film! Packaging includes double LP gram colored vinyl, a poster illustrated by Kevin Eastman , old style tip-on gatefold jackets with satin coating, and a TMNT film poster postcard. Sign up to our mailing list to get first dibs on new releases, sales, exclusive content, and more!
Sign in. When the turtles get word of the Kraang's return, they realize there is an even bigger threat coming to Earth. With the demise of their beloved father and Karai incapacitated, the turtles, April, and Casey infiltrate Super Shredder's new lair to put an end to Oroku Saki once and for all, no matter what it Leo and Donnie disagree about their plan to stop the Kraang invasion. When Leo makes a critical mistake, he is separated from the team and Donnie must step up as a leader. Breakout star Erin Moriarty of " The Boys " shouts out her real-life super squad of actors. Watch now.
It was animated overseas in Japan by Toei Animation. The series featured the Teenage Mutant Ninja Turtles characters created in comic book form by Kevin Eastman and Peter Laird , the property was changed considerably from the darker-toned comic in order to make it more suitable for children.
young hearts run free rod stewart
Sign in. Stars on the purple carpet at the Emmys decide which TV show characters would make great superheroes or supervillains , and more. Watch now. Title: Green with Jealousy 23 Oct Shredder and Krang engineer a love potion that makes Leonardo, Michelangelo, and Raphael all fall in love with Irma. Donatello races for an antidote before Shredder drains a naval submarine of all its power.
They were trained by their anthropomorphic rat sensei in the art of ninjutsu. From their home in the sewers of New York City , they battle petty criminals, evil overlords, mutated creatures, and alien invaders while attempting to remain hidden from society. They were created by Kevin Eastman and Peter Laird. The characters originated in comic books published by Mirage Studios and expanded into cartoon series, films, video games, toys, and other merchandise. The concept arose from a humorous drawing sketched out by Eastman during a casual evening of brainstorming and bad television with Laird.

domain: hobby


Up to 2pcs per person for each model
(This product has a built-in lithium-ion battery, we can only ship up to two pcs per shipment.If you need more than two totally, please split the checkout into multiple shipments and pay separately.)
Tamagotchi Smart, the first wearable Tamagotchi in the Tamagotchi series, is now available!
The more you take care of your Tamagotchi, the more it will love you.
With the touch LCD and microphone, you can even stroke his head and talk to him!
This is the first wearable Tamagotchi, making it even more accessible.
With the optional TamaSma Card, you can add data on the Tamagotchi you can raise and various other items.
Tamagotchi Smart x 1
Charging cable x 1
The contents of the game are the same for all colors.


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More and more people across Connecticut are going solar when it comes to powering their homes.
According to state records, solar panels are going up on homes in Connecticut at a rate of 1,000 per year, a rate that is double what is was just a few years ago.
“It’s worry free. And the system is hassle free in that I don’t even worry about it," said T.J Benoit, who put solar panels on his home last fall. "It’s either on or off and it takes care of itself.”
Benoit has a 20 year lease. He put $13,000 down up front, has no payments, and expects to make that amount up in savings in five years. His $200-per-month electric bill is now cut in half.
"Any time a bright sunny day like today is usually probably a third of it is going back to the grid at least. And that appears as credits at the end of the month on my electric bill,” he said.
Some who have converted to solar, like Gary Williams, of Glastonbury, take advantage of state and federal subsidies. Williams bought his solar panels in April.
“With the state and federal programs that are helping fund this, it’s 50-percent off,” Williams said.
Williams benefited from a program called Solarize Connecticut, where towns get a group discount on solar, and contractors are already screened for homeowners.
So, why is the cost of solar energy for homes suddenly more affordable? The state Clean Energy Finance and Investment Authority, or CEFIA, says besides buying a system outright, there are now lease arrangements with little or no money down.
“Where it was maybe a little bit affordable for folks to go solar before, now it’s making a ton of sense," Kerrie O’Neill, a spokesperson for CEFIA.
The price of an average solar array in Connecticut is $30,000, down from an average cost of $54,000 five years ago.
There are some pros and cons when it comes to fitting a house with solar panels, and it won't work for everyone. If the roof doesn't get enough sun, or if the roof is a few years away from being replaced, solar power won't make for a good choice.
For homeowners who buy the panels, they are responsible for maintaining them and storage of solar power isn't affordable, so the power not used is kicked back to the grid. Homeowners are paid for that excess power at the wholesale rate.
When the house is sold, the panels come with it, unless the homeowner pays to have them removed.
In the case of the Curran family in Waterbury, they believe the solar panels they bought will make their home, which is all electric, even more appealing to a buyer.
“I think it actually modernizes the look of the house actually. We’ve gotten so many complements," Katie Curran said. "All the neighbors have asked us about it and it has generated this little buzz in the neighborhood, and it’s saved us a lot of money already.”
While a solar panel installation takes just a few days, the project must be signed off by town inspectors, and the local utility. To learn more about the different grants, credits and financing available for solar, click here or here.

domain: economics


THE government should reconsider the proposal to improve the welfare of Fire and Rescue Department personnel, including approving the critical allowance.
It was recently reported that the critical allowance, which will benefit more than 14,000 firefighters throughout the country, may not be given out this year.
Housing and Local Government Minister Zuraida Kamaruddin was quoted as saying that apart from approval from Prime Minister Tun Dr Mahathir Mohamad, there are other matters that have to be looked at, including the country’s finances before looking into this issue.
The proposal to introduce better perks for firemen should be supported by all because their task is currently as challenging and demanding as other important agencies.
As a report by national news agency Bernama indicated, Yang di-Pertuan Agong Al-Sultan Abdullah Ri’ayatuddin Al-Mustafa Billah Shah himself has expressed concern for the needs and welfare of firemen, including the critical allowance (online at /bit.ly/ bernama_firemen).
It was also reported that if the critical allowance is implemented this year, an estimated RM18mil is needed to be distributed to firemen at a rate of RM200 a month.
Many of us are still unaware or do not understand how challenging the task and workload of Fire and Rescue Department members are, especially those who are involved in fire-fighting and rescue operations.
The department is also responsible for enforcing laws relating to safety and fire prevention as well as providing efficient and effective humanitarian services.
Firemen’s close relationships with the public and various reports on their selfless acts have made them the first choice to contact when the public needs help in various situations, including accidents and natural disasters such as floods and landslides.
Firefighters are frequently involved in search and rescue operations when people get lost in jungles and in drowning cases.
The ability of the department’s members in such operations cannot be disputed, as they have the skills and appropriate equipment, such as hydraulic cutting tools, for example, which are used to extricate accident victims in badly mangled vehicles.
The department also has skilled personnel who regularly help save pets, capture dangerous wild animals and destroy hornet and bee nests located where they could harm people.
The government should also provide sufficient allocation for human resource development so that they can maintain high technical and effective skills to handle any emergency case.
Sufficient allocation should also be given to the department for the purchase of advanced machinery and equipment while the latest personal protective equipment must be provided.
I also hope that continuous efforts can be made to improve the workplace and housing of the personnel and their families so that they can focus on work while their families are able to live in a conducive environment.
The time has come for us to reward Fire and Rescue Department personnel who are willing to sacrifice their lives to ensure the safety of others, especially during fires and natural disasters.
This would be in line with the theme for the International Firefighters’ Day 2019 celebrations that were held yesterday, “Fire Brigade, the Pillar of National Rescue”.
TAN SRI LEE LAM THYE
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What happened Prince Sihanouk?
Sihanouk died in Beijing in 2012.
Why was Sihanouk exiled?
Sihanouk was released in January 1979 because the Khmer Rouge regime was falling to Vietnamese military forces and needed an advocate in the United Nations. After denouncing the Vietnamese invasion, he dissociated himself from the Khmer Rouge.
How did Sihanouk come to power?
In September 1993, following UN-sponsored elections the previous May, Cambodia’s National Assembly voted to restore the monarchy, and Sihanouk once again became king.
Who ruled Cambodia before the Khmer Rouge?
Cambodia Year Zero. 1975 – Lon Nol is overthrown as the Khmer Rouge led by Pol Pot occupy Phnom Penh.
Who is the Queen of Cambodia?
|Norodom Monineath Sihanouk នរោត្ដម មុនីនាថ សីហនុ|
|Queen Mother of Cambodia|
|Monineath in 2013|
|Queen consort of Cambodia|
|Tenure||24 September 1993 – 7 October 2004|
Are there still princesses in the world?
From Princess Charlotte to Swedish Crown Princess Victoria, meet all the royal princesses of the world. Princess Beatrice of York, from Britain, attended the University of London. She was set to wed fiancé Edoardo Mapelli Mozzi on May 29, but they were forced to postpone their ceremony due to the coronavirus pandemic.
Does Cambodia have a royal family?
The House of Norodom (Khmer: រាជវង្សនរោត្តម) is the ruling royal house of Cambodia. Its members are direct descendants of King Norodom of Cambodia (1860–1904), a son of the “Great-King”, Ang Duong. The current head of the House of Norodom is the current king of Cambodia, Norodom Sihamoni.
Where did Cambodia originate from?
Recent archaeological finds (since 2012) indicate that parts of the region now called Cambodia were inhabited during the second and first millennia BC by a Neolithic hunter and gatherer culture that may have migrated from southeastern China to the Indochinese Peninsula, responsible for the construction of circular …
Is there a Cambodian royal family?
Who is King Sihanouk’s wife?
In April 1952 Sihanouk married Paule Monique Izzi, the daughter of Pomme Peang – a Cambodian, and Jean-François Izzi, a French banker of Italian ancestry. Monique became Sihanouk’s lifelong partner; in the 1990s she changed her name to Monineath.
What was the relationship between Sihanouk and the US like?
Sihanouk had a problematic relationship with the United States. Washington had given only lukewarm support to Cambodian independence. Between 1955 and 1963 Cambodia received almost $US500 million in US economic and military aid, while the CIA actively supported Sihanouk’s rivals.
Who was Prince Sihanouk?
Sihanouk was an intelligent and charismatic figure given to egotism, high living and womanising. He was fond of Western culture, particularly film and music, and occasionally sang Elvis Presley ballads at state dinners.
Where did King Sihanouk go on his holiday?
In January 1970, Sihanouk left Cambodia for a two-month holiday in France, spending his time at a luxury resort in the French Riviera.

domain: history


Scott Walker: I'm tested enough for the world stage
Washington (CNN) Scott Walker will offer his foreign policy vision in a speech Friday mostly by contrasting it with what he terms a \"retreat\" from the world stage by the Obama White House.
\"With all of the challenges we face around the globe today, now is not the time for untested leadership. I have been tested like no other candidate in this race,\" the Wisconsin governor will say, according to excerpts released early Friday morning. \"As President, I will send the following message: the retreat is over.\"
The speech at The Citadel in Charleston, South Carolina, gives Walker, who has fairly limited foreign policy experience and has raised some eyebrows with prior comments, a chance to shore up any nagging doubts. Walker will chastise President Barack Obama for misunderstanding Iran's relationship with ISIS and, more broadly, displaying a passivity and false hope that the world will order itself without American leadership.
\"We've had enough of a President who proclaims that the greatest threat to future generations is climate change,\" Walker will say. \"We are at war with radical Islamic terrorism. It will not go away overnight. This is a generational struggle. And these radical groups will continue to grow if we do not destroy them.\"
Walker will speak on foreign policy about a 15-minute drive away from Marco Rubio, who will be sharing his own vision at nearly the exact same time, also in Charleston.


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Top Mexican in Arlington, VA - Tortas Y Tacos La Chiquita, El Chilango, El Paso
Cafe, El Charrito Caminante, Don Tito, Pedro & Vinny's, Jarochita #2, La Union ...
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NASHUA, N.H. — Senate Republican Leader Bob Dole said Friday he knew nothing of allegations in a Kansas City Star report that his 1986 Senate campaign received what may have been illegal contributions.
"We can't keep track of every contribution, so we've asked the FEC to take a look at it," Dole said.
The Star quoted former executives of a now bankrupt company, Birdview Satellite Communications Inc., as saying they were encouraged or ordered to contribute to his campaign and then were reimbursed by the company.
Dole campaign officials have said they had no knowledge of improper contributions.
Federal Election Commission spokeswoman Karen Finucan said in Washington the agency had received no request for a review from Dole as of Friday. However, she said that if the senator made such a request in writing the FEC staff would look into his records.
Dole, a candidate for the Republican presidential nomination, made his comments in answer to reporters' questions while campaigning.
In a speech in Nashua, the Kansas senator called for a tough federal fiscal policy that could include a one-year freeze on spending as a way to cut the budget deficit by billions of dollars.


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Lifestyle Artist Retreat - October 2022
LifeStyle Artist Retreat – Cancun, Mexico
*Limited Spots Available
We are excited to announce we are launching the Human Garage LifeStyle Artist Retreat Centre this fall in Cancun, Mexico at Akasha Urban Sanctuary!
We are offering 6 members of the Human Garage community an incredible opportunity to be a part of the initial launch in October! This is a unique, all-inclusive learning experience that embodies the work and lifestyle of Human Garage.
You will experience learning, growing, conscious movement, authentic discussions, local jungle adventures and exploration, and a fun, interactive environment.


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Trey Kuyper is an undergraduate senior studying Industrial Design at Arizona State University. He is passionate about both industrial and graphic design, and has completed a Graphic Design Internship at Christ’s Church of the Valley in the fall of 2021. There he was tasked in creating graphics for print and digital purposes for multiple clients in the Valley. Trey also enjoys using his skills in graphic design to collaborate with local artists and hopes to continue to do so in the future. His other interests in design include apparel, footwear, and houseware design.
Trey will be graduating in May of 2022 with a Bachelors in Science in Design and is optimistic about his future in design. He is looking forward to continuing his career in graphic design at Simplicity Group, a financial group in Scottsdale, Arizona.
Outside of design, Trey has many interests. You can find him staying active while playing volleyball, riding his bike, or hiking the local trails in the Valley. In his down time, he enjoys listening to music while sketching or grabbing coffee at a local shop.


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Free UK Mainland Delivery available on orders over £50
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Delivery within 4-5 working days.
Delivery of bespoke products may take longer.
£209.99 (£251.99 inc vat)
The Let’s Go Indoor Rollator is specially designed to be used indoors with its narrow profile to help you manoeuvre through doorways. The rollator stands out from other rollators due to its attractive design. This rollator comes fitted with a full-length padded handlebar, making it easy to use with one hand._
The front castors swivel a full 360 degrees allowing you to turn wherever you need to go. All 4 castors are made from rubber giving you the reassurance that they can perform on any surface without the need to worry that you might get a puncture._


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2012 SAG Awards Fashion: A Skinny Angelina, Lots Of Black Gowns & More
Many stars attended last night's Screen Actors Guild Awards, and black was one of the most popular colors on the red carpet.
Angelina Jolie showed off her particularly thin figure in a draped black gown. Other stars in black included Stacy Keibler, Jayma Mays, Amber Heard, Ashlee Simpson, Emma Stone, Glenn Close, Heather Morris, Tina Fey and Melissa McCarthy.
Check out all the looks on the following pages:


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Mayor Barrett and County Executive Walker Will
Nov. 2, 2004
Marquette University will host the first ever sySTEM Now!
symposium devoted to shaping the future of science and technology.
Key industry, educational, and public sector leaders from across
the state will gather Tuesday, November 9, 2004 on the Marquette
campus to discuss strategies for increasing interest in the fields
of s cience, t echnology, e
ngineering, and m ath ( STEM )
among youth in Wisconsin. By fostering interest in students at
an early age, educators hope to cultivate the industry leaders
that will be needed in the future.
"The drivers of our economic growth are clearly going to
come from the science and technology sectors,” said conference
co-chair Dr. Stan Jaskolski, Dean of the Marquette College of
Engineering. “If the American workforce cannot compete for these
jobs, our national economic growth will be put in great peril.
We've simply got to start earlier, train more students in math
and science, and get them into engineering programs like ours
here at Marquette.”
"There is a declining trend among students choosing science,
technology, engineering and math careers, especially among women
and students of color,” said conference co-chair Van Walling.
“The conference marks the beginning of an aggressive ‘do something!'
campaign to motivate our professionals and our youth.”
The ability to attract and retain skilled workers in high technology
fields will be key to economic growth in the region. Notable speakers
for sySTEM Now! include Milwaukee Mayor Tom Barrett,
Milwaukee County Executive Scott Walker, Milwaukee Public School
Superintendent William Andrekopoulos, Deputy Secretary of Transportation
Ruben Anthony, and Private Industry Council President Gerard Randall.
Panelists will explore ways to motivate the next generation of
scientists, engineers, and technology leaders by discussing the
role of education, as well as public and private employer perspectives.
They will also examine local success stories.
The conference is free and open to the public. However, reservations
are required for all who wish to attend. The event will be held
at the Raynor Memorial Library Conference Center, 1355 W. Wisconsin
Ave. Parking is available in Structure 2, located on 1240 W. Wells
Interested media should contact Anne Broeker in the Office of
Public Affairs at Marquette University.


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A normal phase high performance liquid chromatography method with evaporative light scattering detection was developed for the simultaneous quantification of the lipid constituents of a non-ionic surfactant vesicle (NIV) delivery system consisting of tetra-ethylene glycol mono n-hexadecyl ether, cholesterol and dicetyl phosphate. An accelerated stability study performed at 25°C/60% relative humidity (RH) and 40°C/75% RH indicated that the NIV were chemically stable. Similar results were observed when stored at 4°C for 469 days. This chromatographic method developed is a sensitive, robust and high throughput analytical technique that offers the potential for rapid quantification of lipids in liposomal and vesicular systems. The results of the chromatographic studies were supported by parallel size and zeta potential measurements.
- chromatography, high pressure liquid
- drug delivery systems
- scattering, radiation
- non-ionic surfactant
- lipid analysis
- normal phase HPLC
- evaporative light scattering detection


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They called “Titanique” the show of dreams. fever dreams. And it was, it Yes, really was.
Easily the funniest musical in town right now, Off-Broadway Cuckoo Camp Fest at the Asylum in Chelsea is based on an unsinkable idea: it tells the story of the 1997 film Titanic to the songs of French-Canadian chanteuse Celine Dion.
One hour, 40 minutes without a break. At the Asylum NYC, 307 West 26th St.
It is scandaleux that no one has ever thought of this mashup.
After all, no singer is more closely associated with a (non-musical) film of this magnitude than Celine with James Cameron’s Titanic – the two feed off each other – and the rest of her popular catalog carries the same emotional weight and theatrical narratives as the signature song of the Oscar-winning film My Heart Will Go On.
And co-writers Marla Mindelle, Constantine Rousouli, and Tye Blue deftly throw a boatload of it in wherever they can.
When Jack and Rose first meet on deck while Rose contemplates throwing herself overboard, they sing a duet of “Taking Chances.”
“What do you say about taking risks? How do you feel about jumping off the edge?” They leave. Perfection.
As the captain, oddly known only as Victor Garber, an Irish-tinged Frankie Grande hops through “I Drove All Night” while driving the doomed ship to speed up.
The unsinkable Molly Brown, played by Kathy Deitch, after surviving the tragedy, belts out “All By Myself”: “Those days are goooone!”
When Jaye Alexander, wearing a neon blue flapper wig, yells “River Deep, Mountain High” at the iceberg and forces the other characters to “Lip Sync For Your Lifeboats,” things really get out of hand.
But the most inspiring choice is to make Celine – as weird as she is talented – the protagonist of a story that is in no way about her.
Outrageously funny, Mindelle plays Celine as the omniscient narrator who, as we learn on an opening Titanic museum tour, is actually 150 years old and was on board the ship with our favorite characters. Secure!
She appears from time to time to glorify other characters.
Mindelle’s performance is a sensational, hilarious and deranged twist that rises above a 2 o’clock Las Vegas impression. Yes, if you’re a big Celine fan, eh Hm, a certain tabloid critic, will have you howling over the actress’ borrowed Celine-isms from old viral YouTube videos and quips from the album A New Day Live. But the performance — talkative, occasionally improvised, and quite affectionate — is more than a taunt.
Most impressively, the actress somehow recreates Dion’s superstar energy in a low-budget show, staged in a basement full of columns that smell of Ajax. Whenever she comes on stage, the audience is dizzy to see her.
Stage film parodies have been around for years, but what makes “Titanique” work so well is the multi-million dollar elevator pitch – “Titanic” narrated through Celine songs! — and the talent of the cast, all of whom are as strong singers as they are comedians.
Each role gets a new twist. Rousouli plays Jack as a goofy prat who goes well with Alex Ellis’ Jan Brady-esque tormented Rose. John Riddle’s Cal is Billy Zane if Billy Zane went to Fire Island, and Ryan Duncan turns Ruth, Rose’s uptight mother, into a Joan Crawford who just discovered a wire hanger.
Everyone made me smile until the end, which didn’t happen during the movie Titanic. Director Tye Blue’s staging, cheesy as it must be, is also substantial and oddly grand for a place that was hosting a comedy night minutes after Titanique ended.
What the show could use is a crippling, humorless musical moment that blows our minds. It comes awfully close with a great full cast rendition of “The Prayer,” which Dion often duets with Andrea Bocelli – I’ve even seen one spectator take heart at the same time – but then abruptly cuts off. A moment of serenity here and there would make the laugh even bigger.
But as it is, Titanique is the ideal off-Broadway commercial show. It knows who its audience is — the kind of people who listen to the eight-minute version of “It’s All Coming Back To Me Now” and then click replay — and works hard to unabashedly entertain them.
At the moment the musical is playing until September 25th. But does it have to go down so soon?
https://nypost.com/2022/08/05/titanique-the-musical-review-titanic-parody-hits-the-mark/ The Titanic parody hits the mark


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Actionwood, laminated, coloured wood, 60 mm thickness
Available in the dimensions:
900 x 300 x 60 mm
Our Actionwood is a robust and perfect base material of very high quality for the production of different types of shafts such as: B. rifle or knife stocks as well as for the production of sports bows and other turned products.
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Emission class EN 717-1 (formaldehyde).
And what do you make of it? Maybe another new idea?


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AD|ARC: Linking Government data to support Farming in Scotland
22 July 2021
Alastair McAlpine, Senior Statistician in the Scottish Government’s Rural and Environmental Sciences and Analytical Services division, discusses how the AD|ARC project supports the Scottish Government’s future policies.
ADR UK projects continue to inform UK’s Covid-19 response
19 July 2021
Administrative data research facilitated by ADR UK partners has been crucial in informing UK and devolved government responses to the ongoing Covid-19 pandemic.
Using local-level data to investigate Covid-19 inequalities in England
7 May 2021
CDRC researchers from UCL, the University of Leeds and the University of Liverpool discuss their work investigating local inequalities in England in relation to the impact of Covid-19 as part of the Local Data Spaces pilot project.
Covid-19 impact analysis reports for all local authorities in England are now available online
7 May 2021
A series of reports using local data to analyse the impacts of Covid-19 are now accessible for all local authorities in England as a result of the Local Data Spaces pilot project.
ADR UK-sponsored event explores the importance of data in responding to Covid-19 both locally and nationally
6 May 2021
Yesterday (5 May 2021), ADR UK sponsored the nineteenth instalment of the Institute for Government’s Data Bites series, which explores the theme of ‘getting things done with data in government’.