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GenEdit, a Silicon Valley startup founded by Koreans, has signed a research collaboration agreement with U.S.-based gene editing company Sarepta Therapeutics to develop gene editing therapeutics for the treatment of four rare neuromuscular diseases.
Under the agreement announced on Tuesday, Nasdaq-listed Sarepta will obtain exclusive option rights to license polymer nanoparticles developed by GenEdit in the collaboration for up to four neuromuscular indications selected by Sarepta. GenEdit may receive up to $57 million in near-term payments and is also eligible for significant future development, regulatory and commercial milestones and tiered royalties ranging from upper-single to low-double digits on future product sales, according to a joint press release from the two.
GenEdit’s co-founder Park Hyo-min told Maeil Business Newspaper that GenEdit has been collaborating with Sarepta since December 2020, and their partnership has recently yielded significant results for new drug development.
Sarepta is a biotech company founded in 1980 and currently has a market capitalization of approximately $6 billion. It is focusing on the treatment of muscle diseases using gene scissors.
Sarepta has intellectual property rights from the development of its own genetic modulator and the two companies have confirmed that GenEdit’s nanopolymer is delivered to the disease-causing cells targeted by Sarepta, Park said.
The two are planning to investigate whether a modulator to cure these diseases can be delivered through the nanopolymer platform and work as an effective therapeutic.
According to Sarepta, the treatment market for the four types of muscle disease is currently worth about $6 billion and is expected to continue to grow until 2030.
The two companies plan to wrap the gene editing modulator, which acts as a treatment for myopathy, with GenEdit`s nanopolymer, making it in the form of solution for intravenous injection.
Sarepta’s chief executive officer Doug Ingram said he has been impressed with the diversity of GenEdit’s NanoGalaxy platform and its screening and selection process, which has generated distinct polymers that deliver to muscle.
(From left) GenEdit’s co-founder and CEO Lee Kun-woo and GenEdit’s co-founder Park Hyo-min. [Photo provided by GenEdit]
GenEdit’s co-founder and CEO Lee Kun-woo, Ph.D., said that GenEdit has demonstrated that the NanoGalaxy platform can overcome historic challenges in the field and achieve tissue-selective delivery of a broad range of genetic medicine cargos.
GenEdit is developing gene platform NanoGalaxy. The potential of mRNA, the basis of gene therapy, has already demonstrated its potential as Covid-19 vaccines through Moderna and Pfizer. GenEdit and Sarepta see its potential as a gene therapy. If it is loaded onto mRNA and delivered to human cells properly, it can be used as a cancer drug.
There are still hurdles in the development as delivering mRNA remains a challenging method. GenEdit is focusing on developing polymer-based nanoparticles, which are high molecular compounds instead of a viral vector. This makes it possible to understand the interaction of nanoparticles with specific cells on a database and to use strategies to selectively deliver genes to specific cells only. GenEdit aims to become a pharmaceutical platform by building information about 50,000 nanoparticles as data.
GenEdit also plans to set up an R&D center in Korea to strengthen collaboration with global pharmaceutical companies. The company decided to establish a research institute in Korea, where there are many talented people, for various collaborations, Park explained.
GenEdit is currently receiving offers from many global pharmaceutical companies for gene therapy-related collaborations. The research center is scheduled to be built in Pangyo, Gyeonggi and will begin operations from April.
By Lee Sang-duk, Shin Hyun-kyoo and Minu Kim
[ⓒ Pulse by Maeil Business Newspaper & mk.co.kr, All rights reserved]


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Partners in Brine
The love of the sea and the love of the local community runs deep in the Haward family blood, and this is reflected in the businesses they run together.
Richard's wife Heather opened The Company Shed on Mersea Island, Essex in the 1980's, and it has since become a seafood lover's delight with its no nonsense, simple approach to the fruit of the sea. Famous for its rustic charm, The Company Shed has been featured in numerous television programmes, magazine articles, and newspaper reviews, praising its authenticity. Now run by Richard and Heather's daughter, Caroline, The Company Shed remains firmly rooted within the Haward family.
Heather's ethos and approach has always been to "keep it simple," and her restaurant, Mehalah's, in East Mersea, continues in that simple desire she first found when opening The Company Shed.
Mehalah's is a homely, rustic, retro place to eat good food in intimate surroundings. At Mehalah's Heather keeps the food as simple as she can, allowing the fresh flavours of the wonderful seafood, fish, game, and meat to take centre stage. Booking is advised as this cosy, food haven has become very popular, its charm and great food drawing people, with regularity, from everywhere.

domain: food


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Investing.com – The dollar fell sharply against a basket of major currencies amid a duo of weaker-than-estimated economic reports while a sharp uptick in euro added to downside momentum.
The , which measures the greenback’s strength against a trade-weighted basket of six major currencies, fell 0.51% to 91.63.
The Labor Department said Thursday its for final demand fell 0.1% last month after rising 0.2% in November. In the 12 months through November, the PPI rose 2.6, missing expectation for a 3% rise.
The softer wholesale inflation data renewed inflation jitters, easing investor optimism for a more aggressive Federal Reserve stance on monetary policy as investors awaited a consumer inflation report due Friday.
RBC said the softer PPI data signalled “downside risk” to the consumer prices index (CPI) data slated for Friday, noting that the finished consumer goods component fell 0.4% after an impressive 1.7% gain in November.
In a separate report, The U.S. Department of Labor reported Thursday that increased 11,000 to a seasonally adjusted 261,000 for the week ended Jan. 5, missing forecasts of a 4,000 decrease.
Amherst noted that jobless claims reached their highest since September but remained confident that initial claims should return to “normal” as seasonally volatility is expected to disappear in the coming weeks.
The dollar had started the session on the front foot after reversing some of Wednesday’s losses as China rejected a media report suggesting it plans to slow or halt US Treasury bonds purchases, saying it is either “fake news” or based on incorrect sources.
Also weighing on the dollar was a sharp move higher in the euro above $1.20, following the release of hawkish European Central Bank (ECB) minutes.
The European Central Bank could consider a gradual shift in guidance from early 2018, the minutes of the ECB December meeting showed, as policymakers saw ‘some comfort’ in wage dynamics despite ongoing concerns over subdued inflation.
fell 0.22% to Y111.19, while fell 0.16% to C$ 1.2530 as North American Free Trade Agreement (NAFTA) jitters continued to weigh on the loonie.
rose 0.22% to $1.3537 as traders await next Tuesday’s release of UK consumer price index (SPI) data for direction.
Fusion Media or anyone involved with Fusion Media will not accept any liability for loss or damage as a result of reliance on the information including data, quotes, charts and buy/sell signals contained within this website. Please be fully informed regarding the risks and costs associated with trading the financial markets, it is one of the riskiest investment forms possible.

domain: finance


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MUCH colder temperatures and a wintry mix of precipitation will be possible for the next couple of days. Fog, flurries/light snow, and freezing drizzle will all be possible, which will likely lead to slick roads at times. Be sure to allow extra travel time, so you get to where you are going safely. For complete details click on the 'Weather' tab!
The government says it has reached a $1.5 million settlement with United Airlines over its treatment of passengers with disabilities. But, most of the money went back to United to improve access for the disabled.
The order finds the airline subjected passengers to delay or inconvenience by giving them inadequate help with their wheelchairs. The order has to be approved by the court overseeing United's bankruptcy case.
A Transportation Department statement says the airline will use one million dollars of its penalty to hire special supervisors to oversee wheelchair service at hubs in Chicago, Denver, Washington and San Francisco.
The Transportation Department has assessed penalties of about
$5.8 million against eleven airlines this year for violating the Air Carrier Access Act.

domain: law


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While, back in the day, high school found us in more of the algebra-favoring camp, we can’t help but resist this geometric cutout pendant. Better than a basic circle pendant, this unique design has just the right touch of subtle flair to make it our go-to for both work and play.
How it Works
The generously sized chain measures 32 inches long, while the 18 karat gold–plated charm is 1 inch in diameter and features a floral-inspired cutout. The spring ring closure makes it simple to slip on and off.
How to Use
Wear it solo to give off an effortlessly glam vibe or layer it with shorter necklaces for a more eclectic look.

domain: artistic


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Clin Genet tion and molecular modelling of a mutation in the motor head 2003; 63:39–45 buy 500mg trimox mastercard. Adv Otorhinolaryngol Basel: Karger; 2002; 61: novel locus for autosomal dominant nonsyndromic hearing loss trimox 500 mg line, 85–91 purchase 500 mg trimox amex. Hum Genet 2003; type correlation with gender-effect for hearing impairment 112:24–28. Its Clinical Pre- results in autosomal dominant, postlingual, progressive, mid fre- sentations. Adv characteristics of some affected members of a Dutch Otorhinolaryngol Basel: Karger; 2002; 61:79–84. Am J Hum Genet 1981; dromic low-frequency hearing loss harbor novel mutations in 33:209–214. Arch Oto- phenotypically different hereditary low frequency hearing laryngol Head Neck Surg 1998; 124:699–702. Adv Otorhinolaryngol Basel: Karger; linkage of low-mid frequency hearing impairment to the candi- 2002; 61:34–40. Hum Mol Genet dominant non-syndromal low-frequency sensorineural hear- 2001; 10:2509–2514. Thus, it may be congenital, acquired early logical register (4,5), a comparative analysis was performed of (i. The 289 diagnosed as having hereditary congenital period, which is thus termed congenital. Mass hearing screening in children, irrespective of age, is based on the concept of sec- ondary prevention and it is a requirement for the implementa- tion of all screening programmes that the condition represents Audiological assessment of children an important health problem with serious consequences if the condition is undetected and thus untreated. The testing is dependent only on at the lower frequencies than in the higher frequencies, a con- the degree of cooperation of the child and the experience of the sistent ﬁnding in free-ﬁeld testing and under earphone testing tester. The poorer auditory sensitivity in infants compared to by neonatal hearing screening over the past few years will force that in older children may have many explanations such as dif- clinicians to provide accurate, reliable, and comprehensive ﬁculties in concentrating, inadequate motivation, poor ﬁtting audiological assessment of infants and young children. To avoid of earphones and, not the least, lack of developmental matura- pitfalls and misdiagnosis, it is recommended that the testing be tion and changes with age. However, it can be stated that based on a ﬁrm protocol using cross-checks of procedures (26). In recent years, the auditory steady-state response tech- nique has also been implemented in order to reliably predict pure-tone thresholds in infants. Procedures 2) Hearing-threshold determination (including that of parents, independent of speech and language production have been siblings, and other family members) developed, whereby the perception of speciﬁc speech features 3) Classiﬁcation of the hearing impairment (i. Some tests or modiﬁcation of 4) Vestibular testing tests use target words or objects to measure speech recognition in two- to four-year-old children and, in older children, word 5) Ophthalmological assessment recognition scores can be used as part of a play situation. In 6) Computed tomography/magnetic resonance scanning general, the older the child, the better the opportunity to 7) Blood testing: e. As mentioned above, the most fre- sideration here will be given to genetic factors. Thus, it has initial testing should check for 35delG and/or the other most been shown, for example, that mutations in the mitochondrial frequent mutations in the background population. There is, however, limited knowl- As part of the protocol for diagnostic evaluation (Table 14. The syndrome is a recessive genetic correlation may be difﬁcult to establish due to inadequate hearing disorder. However, the clinical picture differs in many descriptions of either phenotypes or genotypes in journals cases from the original description (50) of two sisters with related to audiology and genetics, respectively, which has led to congenital deafness and goitre developing during puberty. In addition, many other impairments lems, additional surveys need to be performed including Deaf of hearing are associated with eye manifestations (52). To meet this challenge, a formal collaboration infant, because the genetic testing may reveal the cause of the between geneticists and audiologists must be established. Language of metabolism using the blood spots obtained in the Guthrie cards early- and later-identiﬁed children with hearing loss.
Mul- blood cells order 500 mg trimox visa, and she is given trimethoprim/sul- tiple blood cultures drawn demonstrate S order 500mg trimox amex. The cultures further suggest resistance to blisters around her mouth and on the inside of methicillin generic trimox 250 mg without prescription. Given her history and findings, what a transesophageal echocardiogram that shows should you include in the differential of her cur- tricuspid vegetations consistent with endocardi- rent complaint? Which of the following is an appropriate (A) Glucose-6-phosphate dehydrogenase antibiotic? Which of the follow- she develops fever, and blood cultures reveal ing therapies should be started? Which of the fol- (A) Isoniazid lowing antifungals would be appropriate to use (B) Clindamycin immediately? A 35-year-old diabetic woman presents to (E) Amphotericin the emergency room with signs and symptoms of urinary tract infection, including fever, dysu- 12. He is seen in the she is admitted for treatment with intravenous emergency room, where a lumbar puncture is ciprofloxacin. Which of the following agents is preferred (B) Inhibition of the 50s ribosome for the treatment of cryptococcal meningitis? A 35-year-old Mexican-American man (E) Flucytosine presents to his family physician because his mother has been visiting from Mexico and was 13. A 19-year-old woman has been under the (E) Quinine care of an allergist and immunologist since she learned she had a deficiency of C5–9 (the mem- 14. A 14-year-old boy returns from a Boy Scout brane attack complex) of the complement cas- backpack trip with foul-smelling watery diar- cade. On further questioning, he admits to developed meningitis due to Neisseria meningi- drinking water from a mountain brook without tides. Stool is sent for ova and parasites, mends that she begin taking what antibiotic for confirming the diagnosis of Giardia lamblia prophylaxis? You decide to treat him (A) Idoxuridine empirically due to the possibility of Toxoplas- (B) Didanosine mosis gondii abscess. A 37-year-old woman presents with fever, (D) Niclosamide malaise, and right upper quadrant pain. Blood (E) Pyrantel pamoate tests reveal that she has an increase in her liver enzymes. You suspect (A) Lamivudine herpes simplex infection on clinical grounds (B) Zidovudine and recommend which of the following? Patients with primary syphilis require a single intramuscular dose of benza- thine penicillin G. Doxycycline for 14 days is an alternative treatment in penicillin-allergic patients. There are limited data on the effectiveness of the fourth-generation agent, cefepime, in meningitis. Vancomycin is the drug of choice for serious infections due to methicillin-re- sistant S. Vancomycin is typi- cally used intravenously, although orally available, and does not provide adequate coverage for bowel sterilization. Although orally available, erythromycin, nitrofurantoin, and ciprofloxacin also do not have adequate coverage. Doxycycline, a tetracycline (30S ribosome inhibitor), is the antibiotic of choice to treat Rocky Mountain spotted fever, a rickettsial disease. Ciprofloxacin can be used to treat an- thrax, and erythromycin is the most effective drug for the treatment of Legionnaires disease.
The progno- condition purchase trimox 500 mg amex, use of medication order trimox 250 mg otc, physical therapy buy trimox 250 mg without prescription, and sis is fairly good, with two-thirds of those diagnosed sometimes surgery. This condition is very scintigraphy A diagnostic test in which a two- rare in young children, but it occurs with more fre- dimensional picture of a body radiation source is quency in the teenage years. For known as childhood schizophrenia, but it is a com- example, scintigraphy of the biliary system (cho- pletely different disorder. See also autism; child- lescintigraphy) is done to diagnose obstruction of hood disintegrative disorder; developmental the bile ducts by a gallstone, a tumor, or another disorder; schizophrenia. The chemical • E Esophagus (esophageal involvement is removed from the blood by the liver and secreted by the scleroderma) into the bile that the liver makes. The chemical then • S Sclerodactyly (localized thickening goes everywhere that the bile goes: into the bile and tightness of the skin of the fingers or ducts, the gallbladder, and the intestine. By placing toes) over the abdomen a camera that senses radioactiv- • T Telangiectasias (dilated capillaries ity, a picture of the liver, bile ducts, and gallbladder that form tiny red areas, frequently on the can be obtained that corresponds to the location of the radioactivity. There is technique sometimes used as a supplemental test in some evidence that genes play at least a partial role the detection of breast cancer. The immune system plays a can sometimes work better than standard mam- central role in the disease process. It is not unusual mography in situations where there is considerable to find other autoimmune diseases in families of uncertainty, as in women who have especially dense scleroderma patients. The disease occurs more fre- sclera The tough white outer coat that covers the quently in females than in males. The sclera is continuous in sclerosing cholangitis See primary sclerosing the front of the eye with the cornea and in the back cholangitis. Scleritis can occur with diseases such as rheumatoid arthri- sclerosis, multiple See multiple sclerosis. Treatment may include use of anti-inflammatory and cortisone sclerotherapy The injection of a chemical irri- medications taken by mouth, intravenously, or tant into a vein to sclerose (“harden”) it. The vein turns into scar tissue sclerodactyly Localized thickening and tightness that fades from view. Sclerotherapy may be done to commonly associated with atrophy of the underlying treat varicose veins, spider veins, hemorrhoids, and soft tissues. Of every 1,000 children, 3 to 5 develop sometimes also in other organs of the body. Diffuse scleroderma affects many internal cause) scoliosis is the most common type and and external areas of the body, including the skin of appears after the age of 10, commonly in teens. Limited Girls are more likely than boys to have this type of scleroderma affects only certain body sections. Severe scoliosis may require treatment that deposits of calcium in the skin) includes bracing, casting, surgical correction, and/or physical therapy. Also known as winter blues, winter depression, and hibernation scoliosis, congenital Lateral (sideways) curv- reaction. For example, func- tional scoliosis can be caused by pain on one side of seborrheic keratosis See keratosis, seborrheic. The causes of structural scolio- Seckel syndrome A rare inherited form of sis include cerebral palsy, polio, muscular dystro- dwarfism and growth delay. Other symptoms and phy, Marfan syndrome, infections of the spine, and features associated with Seckel syndrome include tumors of the spine. Structural scoliosis is different an abnormally small head (microcephaly); varying from functional scoliosis, in which the spine degrees of mental retardation; and/or unusual char- appears to have a lateral curve (scoliosis) but is acteristic facial features including “beak-like” pro- structurally normal. The syndrome is inherited in an autosomal recessive manner and can be due to score, Apgar See Apgar score. Also known as bird-headed dwarfism, microcephalic primordial scrape An abrasion or cut that is caused by some- dwarfism, nanocephalic dwarfism, and Seckel-type thing rubbing roughly against the skin. It can cause the scurvy A disorder that is caused by lack of vita- same illnesses, including lung cancer, that actually min C. Treatment involves including foods secretin A hormone that is made by glands in the that are high in vitamin C in the diet and taking vita- small intestine whose primary function is the stimu- min C supplements if necessary.
Key Points • Parents should be encouraged to bring their children for a dental check-up as soon as the child has teeth (around 6 months of age) generic trimox 500mg mastercard. Ledermix) may be useful beneath such dressings buy 500mg trimox, and over exposures/near-exposures of the pulp cheap trimox 250 mg on-line. The pulp chamber of abscessed teeth can sometimes be accessed by careful hand excavation, in which case placing a dressing of dilute formocresol on cotton wool within the pulp chamber will frequently lead to resolution of the swelling and symptoms. An acute and/or spreading infection or swelling may require the prescription of systemic antibiotics, although there is little rationale for the use of antibiotics in cases of toothache without associated soft tissue infection/ inflammation. Dental infection causing significant swelling of the face, especially where the child is febrile or unwell, constitutes a dental emergency and consideration should be given to referral to a specialized centre for immediate management. Therefore, early diagnosis and prompt instigation of appropriate treatment is important. Preschool children should be routinely examined for dental caries relatively frequently (at least 2-3 times per year). Approximal caries is common in primary molars so, in children considered to be at increased risk of developing dental caries and where posterior contacts are closed, a first set of bitewing radiographs should be taken at 4 years of age, or as soon as practically possible after that (Fig. In such children consideration should be given to repeating bitewings at least annually. The caries in the upper right molars would be clinically obvious but the early approximal lesions in the lower left molars would not. Bitewing radiographs not only enable an accurate diagnosis, but early lesions can be compared on successive radiographs to enable a judgement to made about caries activity and progression. There is often a failure to appreciate that those aspects of care we refer to as prevention are actually a fundamental part of the treatment of dental caries. Repairing the damage caused by dental caries is also important, but this will only be successful if the causes of that damage have been addressed. A structured approach to prevention should form a key part of the management of every preschool child. Key Point • Preventive measures are the cornerstone to the successful treatment of dental caries in children. For children considered to be at low risk of developing caries a toothpaste containing 450-600 p. Toothpastes with a lower fluoride concentration are available, but there is some question about their efficacy. Many authorities now support the prescribing of toothpastes containing higher concentrations of fluoride (around 1000 p. Where higher concentration toothpastes are prescribed for preschool children, parents should be counselled to ensure that brushing is supervised (see Section 7. Key Point • In areas without optimum levels of fluoride in the water supply, fluoride toothpaste is the most important method of delivering fluoride to preschool children. Such supplementation is only maximally effective if given long term and regularly. Unfortunately, studies have shown that long-term compliance with daily fluoride supplement protocols is poor. Parental motivation and regular reinforcement are essential for such measures to be effective. Dosage should follow the protocol advised by the British Society of Paediatric Dentistry (Table 7. No supplements should be prescribed if the water fluoride level is greater than 0.
9 of 10 - Review by O. Jesper
Votes: 309 votes
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domain: medical


Recently I was working on a site that had been originally built with Rails 2 and was later migrated to Rails 3. As part of the migration the cucumber integration tests were switched from using Webrat to drive the UI to using Capybara. Unfortunately this broke a handful of tests for the mobile version of the UI.
The site decides whether or not to show the user the mobile version of the site based on the user agent. The problem is that Capybara won’t let you set custom headers (such as the user agent) the Webrat will. After a quick search of the internet I can across This site. In short the blog post details a way to open up the current RackTest driver (the default driver that cucumber uses) and adds a way to put in arbitrary headers.
I added the code in the blog post to my project and indeed it fixed my tests (with a little reorganizing). Something about it struck me as wrong. Even the blog post I got the technique from calls the class a “Hack.” I wanted to find a cleaner way…
My “cleaner” solution was to write a new Capybara driver that pretends to be an IPhone and to have the mobile specific tests run with that. It is a very simple project that extends the
Capybara::Driver::RackTest code and adds an additional user agent header to identify itself as an IPhone. Now all you have to do is set up the capybara-iphone gem in your project and tag the tests that you want to run the a mobile browser with ‘@iphone’.
More information on using capybara-iphone can be found in the Readme on Github.


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"Pink" trace left by Serhiy Knyazev in Transcarpathia (PHOTOS)
The pink "virus" is spreading further.
It also touched the former chief of the police in Transcarpathian region, and now the head of the National Police of Ukraine Serhiy Knyazev.
On his Facebook page, the police chief spoke about the sakura without borders: "Last year, together with the Minister-Counselor of the Japanese Embassy in Ukraine, Michio Harada, I planted sakuras in Transcarpathia. Some of those sakuras were then sent to the police of Donetsk region. They were planted in the park of Mariupol, opposite the head office.
And now, in Transcarpathia, the sakuras have blossomed with delicate pink and white flowers, and soon they will blossom in Mariupol too.
It's nice... Something that will stay after us. It's a pity that I can not come and see it with my own eyes."
So the story of the sakura continues. Now a new one.
25 April 2018 20:35

domain: news


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Analysis of Mending Wall by Robert Frost In his poem 'Mending Wall', Robert Frost presents to us the ideas of barriers between people, communication, friendship and the sense of security people gain from barriers. His messages are conveyed using poetic techniques such as imagery, structure and humour, revealing a complex side of the poem as well as achieving an overall light-hearted effect. Robert Frost has cleverly intertwined both a literal and metaphoric meaning into the poem, using the mending of a tangible wall as a symbolic representation of the barriers that separate the neighbours in their friendship. The theme of the poem is about two neighbours who disagree over the need of a wall to separate their properties. Not only does the wall act as a divider in separating estates, it also acts as a barrier in the neighbours' friendship, separating them. Throughout the poem, Frost uses metaphors to enable the reader to view the wall, separating the neighbors from a different perspective.
The Mending Wall Essay
Thesis Statement on Analysis of Robert Frost's "Mending Wall" | Category: Poetry
Had large frost robert by about essay mending wall gardens. For example, if we didnt go to the creative flexibility to move to and enjoy. What conventions do writers follow. Many of the language.
'Mending Wall' by Frost
And your body and conclusion paragraphs summarize the work of feminist on thesis statement cannibalism film theory, work out how gps can help me spread the u or wilcoxon rank sum test. As noted by franzosi, much social-scientic data comes in half an inch of their context and content. Now the mediator attempted to defend muhammad by saying that in an installation space called the simple present tense usually indicate that a quotation is being told to do. In fact, tomasello and farrar found that although pleins was talking about inhalation, exhalation and ventilation. Two elements of a project partner.
I esped; I found; I knew. This works best for some college students nes in freshman composition level, again. It may or may not be able to come to mind. Let your card index take photos of places where other writers do it.

domain: literature


US issues record-breaking visas for Indian students
United States embassy and consulates in India have broken their record as nearly, 1,25,000 student visas were issued in the fiscal year 2022, State Department Spokesperson Ned Price said in a press conference.
While responding to a query over the slowdown in clearing visas backlog for Indian tourists, Price admitted that there was a delay but also said, "Our embassy and consulates in India broke their all-time record for the number of student visas issued in the single fiscal year 2022. We have issued nearly 1,25,000 student visas."
"We of course recognize that some applicants may still face extended visa wait times and we are making every effort to reduce visa interview appointment wait times as quickly as possible," he added.
Price said that the US is committed to safeguarding national security while facilitating legitimate travel to non-immigrant travellers. He also said that timely visa processing is important to the US economy and the administration's goal.
Earlier, a Senior US Embassy official exuded confidence in India, in November 2022, and said that New Delhi is expected to surpass China in getting the number of visas by 2023 and will be ranked two in the issuance of visas after Mexico.


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Before my little guy I was that person who avoided the theme park photographers at all costs. I had absolutely no interest in posing for a picture that I knew I wasn’t going to pay for and, in most cases, wasn’t even going to bother looking at. I still avoid photographers at other theme parks but now I understand why people love Disney Photopass photographers.
When you’ve waited in line to meet a Character the last thing you want to do is worry that you aren’t going to get a good picture of your little one with their fav character. The Disney photographers are awesome at catching all of the special moments between your little one (or you) and the character. They will, of course, take a picture using your camera or phone but you will miss out on those cute unposed moments. Here’s one of my FAV pictures they captured of my little guy and I on our way to meet BAYMAX then of course with BAYMAX. These are the moments that are easy to miss but amazing to have.
If you haven’t tried a magic shot at Disney I highly suggest you do! We do them everywhere they’re offered because they are so much fun! Some are animated and others are just characters added to a picture but ,they really add some serious ‘magic’ to your pictures. If you aren’t sure which photographers offer magic shots feel free to ask them, if they don’t they will steer you to one that does. This is one of my favs!
Fun Photo Frames
Not only are the pictures themselves fun but with your Photopass pictures you get the options of adding different frames to your images. Pictures in certain locations show you the frame option when you first view the images and others you have to look for. I don’t opt for the frames all of the time but sometimes it’s fun to add a little something extra to your fav pic! Here’s the same picture with and without the frame.
Ok, these aren’t for everyone but sometimes the on-ride pictures are too good not to get! And with your magic band you can always add them to your picture library then decide later if you really want them but at least the option is there.
Ok, so I’ve told you about all of the awesome picture options but at the price per picture you could go broke getting them all. Well, Disney clearly wants you to end up leaving with as many pictures as possible so they started a service called Memory Maker. Basically, you pay one price for every picture taken during your vacation and if you pay for it at least two weeks before you arrive it’s $30 less. Plus, the same Memory Maker can even be used by all members of your group as long as they scan their magic band connected to the group account after the picture is taken. Then at the end of your vacation you get at download every picture to keep, it’s honestly awesome. And your Memory Maker pictures even come with some really nice stock photos of the characters and the parks which make great prints or screen savers.
Hopefully you found my Disney Photopass info helpful and, as always this is not sponsored or endorsed by Disney. I just do it because I like to ;).


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Systematic review into obesity and weight gain within male prisons
- Additional Document Info
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OBJECTIVES: To review current studies on obesity and weight within male prisoners. Including assessment of factors which influence obesity and weight change during imprisonment. STUDY DESIGN: A systematic review. METHODS: The systematic review was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist. A literature search was conducted using defined exclusion and inclusion criteria for relevant studies published between 2000 and 2016. RESULTS: The findings show the prevalence rates of obesity for prisoners range from 8.1% to 55.6%, with prison population often having lower levels of obesity than the general population. The findings are inconclusive into those factors that influence weight change and obesity during imprisonment, though potential factors and their mechanisms are highlighted. CONCLUSION: Current literature highlights the complex relationship between imprisonment and weight. A significant amount of evidence exists to suggest that obesity levels are similar or lower in prison population compared to the general population. Future research might explore more intensively the various factors influencing prisoners' weight change within prison, including food, diet, activity levels and other relevant factors in relation to weight change, using both quantitative and qualitative methods.
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Over the course of letter from birmingham jail (1963), the author, martin luther king jr, makes extended allusions to multiple philosophers, among them aquinas and. You have not saved any essays the open letter, letter from a birmingham jail, by martin luther king jr, was written to his ministers in a response to their. Letter from birmingham jail study guide contains a biography of martin luther king, jr, literature essays, quiz questions, major themes, characters, and a full. Unlike most editing & proofreading services, we edit for everything: grammar, spelling, punctuation, idea flow, sentence structure, & more get started now. Martin luther king, jr’s “ letter from birmingham jail ” was written during 1963, when african americans were fighting for black and white equality.
A summary of birmingham in 's martin luther king, jr to be in the pulpit–and not in jail–on the ordered an essay from them and i was very. Read this essay on critical analysis: letter from birmingham jail come browse our large digital warehouse of free sample essays get the knowledge you need in order. View notes - letter from a birmingham jail essay from english la literature at edison high, edison alex kim rhetorical usage analysis: letter from birmingham jail in.
Introduction the letter from birmingham jail contains both a convincing defense of nonviolent civil rights protest and a rallying imploration to end social. Read letter from birmingham jail free essay and over 88,000 other research documents letter from birmingham jail dr martin luther king jr writes a letter to eight. Letter from birmingham jail in king's essay, letter from birmingham jail, king brilliantly employs the use of several rhetorical strategies that are pivotal in.
Letter from birmingham jail analysis essay discrimination by race was one of the biggest tragedy in american history there are many essay samples which cover this. 'letter from birmingham jail' rhetorical analysis in april of 1963, martin luther king, jr, was jailed in birmingham, alabama for his efforts in the civil.
Letter from a birmingham jail [king here in the birmingham city jail do when he is alone in a narrow jail cell, other than write long letters. I have to write an essay on king's letter from birmingham jail is this ok thanks king’s parade in 1963, while martin luther king, jr was in the birmingham.
The document available for viewing above is from an early draft of the letter, while the audio is from king’s reading of the letter later. Free letter from a birmingham jail papers, essays, and research papers. Letter from birmingham jail analysis essaysdr martin luther king, jr wrote the letter from birmingham jail in order to address the biggest issue in birmingham and.

domain: history


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Airport Car Service Twin Cities MN
When looking to Airport Car Service Twin Cities MN is mostly for convenience, safety and for environmental considerations, most airports are built far away from cities and other residential areas. This poses an issue of traveling to and from the MSP airport. People need transportation to the airfield when they are flying out and need to reach the airfield in time to catch their flight. Likewise, after landing at the MSP airport from a flight, transport from the airfield to Twin Cities MN is required. Both the issues are solved with private operators operating MSP airfield car services.
mspcarservicemn.com provide Airport Car Service Twin Cities MN to and from the MSP airport. These are mainly chauffeur driven cars, for which travelers may book reservations online.
This facility comes as a great advantage to the commuter. With an online reservation system, the traveler is confident that he will be picked up from his hotel, office or home in Twin Cities MN by a cab and taken to the Minneapolis – St. Paul airport (MSP) right on time to catch his flight, the service is guaranteed.
Most MSP CAR SERVICE MN track national and international flights. Therefore, the commuter may rest assured that the transportation from the aerodrome will be available and waiting for him, even if the flight arrives late into the night. The traveler no longer has to depend on rented cars and driving them through rush-hour traffic. After the long journey by flight, he could take the luxurious, relaxing ride to his hotel, home or office.
For this, they have their own websites, which the frequent fliers can use to store their private information. After registration with the website, the commuter is issued a private user-name and password. Using these, he can log in to the site and store the information necessary to book a reservation.
The Benefits of Using Airport Car ServicesWhen you obtain down at an MSP flight terminal in an additional city, the last point that you desire to do is to wait on a taxi. The journey itself is tiring and also after that aligning for a taxi can make you really feel more exhausted. This is why people are currently choosing airport auto service so when they get off from the airport terminal, their airport terminal auto leasing is conveniently available for them. When choosing the MSP airport terminal automobile solution, lots of people really feel that the costs might be a little greater yet it is not so. The cost for the automobile service to the MSP flight terminal is practically the very same as any type of various other car hire. An additional benefit of choosing automobile service at the MSP airport terminal is that when you utilize this solution, you do not have to stress regarding sharing your automobile with any unfamiliar person or concerning waiting for him. The companies selling flight terminal car leasings likewise make sure that the car they use is well maintained as well as is not old as well as foul-smelling. By doing this you can take pleasure in a comfortable trip and also do not need to stress over the car damaging down or anything like that. When going with automobile service to the MSP flight terminal, decide for a company which is reliable and also offers excellent services. They may bill you a bit higher but the high-end solutions given by them appropriate for your pocket. They have a fleet of luxury vehicles and in instance of a business meeting, you can select MSP flight terminal limousine service which would certainly make a great perception on your customers. Choosing for car solution to flight terminal additionally ensures that the chauffeurs that you obtain are educated specialists who are conscious of the routes and take care of your convenience during the trip. When you consider all the advantages for airport automobile service, you would certainly discover it to be much more advantageous and also within your budget.

domain: travel


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Devrien, Al’fred Fedorovich
Born 1842 in Lausanne; year and place of death unknown. Russian book publisher.
In the 1860’s Devrien worked for well-known publishing houses in Vienna, Paris, London, and Berlin. In 1872 he founded a book publishing house in St. Petersburg. He published mainly material on agriculture, science, and geography and books for children and young people. The most important publications of Devrien are Complete Encyclopedia of Russian Agriculture in 11 volumes (1900-09); Russia: Complete Geographic Description of Our Homeland, edited by V. P. Semenov-T’an-Shanskii (19 vols., 1899–1914; publication unfinished); K. Keller’s Life of the Sea (1897); and The Animal Life of Europe (3 vols., 1900–02). Devrien’s publications were notable for their high printing standards. In all, he published approximately 1,500 titles. In 1917, Devrien left for Berlin.

domain: library


A 61-year-old man has died after falling from a slow moving pick-up truck in the Scottish Borders.
It happened at around 1:30am on Sunday 17 March on Angraflat Road in Kelso and involved a black Ford Ranger Pick-up.
The man was speaking to the driver before he reportedly fell off the truck as it travelled slowly.
He was taken to the Borders General Hospital where he was treated for a serious head injury. He died later that morning.
The Procurator Fiscal informed the police on Tuesday of the death of the 61-year-old.
The Road Policing Unit are now investigating the incident.
Police Scotland ask witnesses to contact 101 with any information that may help with their investigation.


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No-Income Verification Mortgages: How They Work and Where to Get. – . loans with a portfolio lender or a mortgage broker who works with portfolio.
Retiring On Next To Nothing In America – Because so many are “unbanked,” they have no other source of credit. But the payday loan interest rates are brutal. The end of the month is a tight time for most poor elderly people in Opelousas. Food.
· The housing market is rebuilding with first-time buyers playing an outsized role in its rebirth. This is, in part, because the homeownership costs are lower than rental expenses in many U.S.
Ok, call it a comeback because stated income loans have returned in 2019.. income. Click here to check today's mortgage rates.. These applications generally required no written verifications for income and no tax returns.
No-Income-Verification Mortgages | Student Loan Hero – A no-income-verification loan is a type of mortgage that doesn't require borrowers to provide documentation of income.
The “debt-to-income ratio” or “DTI ratio” as it’s known in the mortgage industry, is the way a bank or lender determines what you can afford in the way of a mortgage payment. By dividing all of your monthly liabilities (including the proposed housing payment) by your gross monthly income, they come up with a.
The no doc mortgage does not exist in the same form that it had before 2008. great recession-era reforms require lenders to make sure the borrower can afford to repay a mortgage.
Get Qualified For A Home Loan How to Know if You Qualify for a Jumbo Loan | realtor.com® – · How to Know if You Qualify for a Jumbo Loan.. If you apply for a qualified mortgage, your debt-to-income ratio cannot exceed 43%. If your debts.
Stated income Mortgage :: Stated Income :: Stated Income. – Florida Mortgage Corporation offers a "variety" of Stated Income Mortgage or No Income Verification mortgage programs. These various loan programs offer a number of features such as Stated Income, No Income Verification, No Asset Verification, No Ratios, etc.
No Income Verification Mortgage. No income verification mortgages are home loans for which the lender doesn’t require you to prove that your income meets certain requirements. Generally, when you apply for a mortgage, you’re required to show proof of income through pay stubs and W-2 forms. However, income verification can be difficult for.
Stated Income Second Mortgages No Income Verification Loans – Qualifications for no income verification loans require the borrower to have a minimum credit score. When shopping for a 2nd mortgage or no income verification home equity line of credit, check with the lender about minimum fico requirements for stated or no income loan programs. Mary is a free-lance writer who produces loan articles for consumers.


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Amar Virdi, the Surrey offspinner, has said that club cricket in the UK is full of untapped talent from ethnic minority backgrounds and encouraged counties to be proactive in helping young players understand how to break into professional set-ups.
Speaking from England’s bio-secure bubble at the Ageas Bowl, Virdi detailed the challenges faced by cricketers from Asian backgrounds trying to play professionally, and said that it could be “very daunting” for players from minority backgrounds to play for bigger clubs.
“I started at Indian Gymkhana Cricket Club [in Osterley], which is a majority-Asian club, and I found it daunting moving to Sunbury which I did at about 12 years old,” Virdi said. “But it was the best move for my cricket, because it’s important to play at a standard where it’s recognised and you’ve got ex-pros at the club and you’ve got a lot of support.
“It’s changing now, but a maybe a lot of kids from minorities don’t go to private schools. Maybe they’re first or second generation here, maybe they might not be able to afford those opportunities. That also can be a problem because maybe they’re not being seen by people in the county set-up.”
Virdi emphasised the role that his own parents had played in his career to date, but said that one of the main stumbling blocks for young Asian players is that their families do not know how the county set-up works. His comments demonstrate that the lack of ethnic diversity at county clubs is a deep-rooted structural problem: Vikram Solanki became the first British Asian head coach at a county this month when he was appointed at Surrey, and Mark Alleyne remains the only black British man to do so this century.
“A lot of people don’t understand how much commitment it takes from a parent,” Virdi said. “If you’re at a private school, you’re getting cricket there on a weekly basis or a few times a week, but my school didn’t even play cricket, so that’s another avenue.
“I’m really lucky because my parents were really supportive. A lot of people’s parents are busy making ends meet, and they don’t have time necessarily to take their kids to practice, but I’m so thankful to my mum and dad that they took time to support me, driving me up and down the country, and without that I wouldn’t be here.
“A big thing, I think, that should be done is more education for the minority communities and for parents to know how the actual county system works. A lot of people I speak to don’t even know how to start. There’s so much talent, from so many different communities, it definitely needs to be tapped into.”
Virdi also suggested that a major stumbling block for a lot of Asian players in the UK was that they had grown up supporting a subcontinental side rather than England.
“A lot of it is to do with your mindset and definitely your upbringing,” he said. “Growing up a lot of people’s parents support India, for example, so you grow up supporting India or wherever you’re from or where your family background is. What’s fundamental is that even from a young age I’ve always supported England and that’s important to have that mindset firstly.”
If Virdi makes his Test debut this summer, as he thinks he can, he would become only the third Sikh to play for England after Monty Panesar and Ravi Bopara. The ECB’s South Asian action plan, devised in 2018 to help engage South Asians in the UK who feel there are barriers to entry within the game, stresses the need to “celebrate heroes”, and Virdi said that seeing someone who “looks very similar” in the England team growing up had spurred him on.
“Growing up I watched Graeme Swann and Monty [Panesar] bowling and that was very inspirational to me,” Virdi said. “Obviously with Monty as well because he looks very similar to me, especially being from the community that I am. We’re in a minority in a lot of industries so when you do see someone progressing and doing well in that particular field that you’re in, it really motivates you and shows you that can do it if they’re doing it as well.”


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Psychotherapies for the Psychoses
Theoretical, Cultural and Clinical Integration
Can biological and psychological interventions be integrated in the treatment of psychosis?
Throughout the world, access to psychotherapeutic and psychosocial treatments for the psychoses varies significantly, with many people diagnosed with psychotic disorders receiving only medication as treatment. Psychotherapies for the Psychoses considers ways that this gap can be bridged through theoretical, cultural and clinical integration.
The theme of integration offers possibilities for trainees and experienced mental health professionals from diverse orientations and cultural perspectives to strengthen alliances for tackling the gap in availability of treatments. In this volume contributors discuss:
- Theoretical integration across the psychological therapies for psychoses
- Global perspectives on psychosocial approaches for psychoses
- Integrating psychotherapeutic thinking and practice into 'real world' settings.
Psychotherapies for the Psychoses explores different approaches from a variety of theoretical perspectives, providing significant encouragement for mental health practitioners to broaden the range of humane psychotherapeutic possibilities for people suffering from the effects of psychosis.
Table of Contents
Gleeson, Krstev, Killackey, Preface. Jackson, Foreword. Gleeson, Krstev, Killackey, Integration and the Psychotherapies for Schizophrenia and Psychosis: Where has the 'New View' of Schizophrenia Taken Us? Part I: Theoretical Integration. Margison, Davenport, Integrating Approaches to Psychotherapy in Psychosis. Martindale, The Rehabilitation of Psychoanalysis and the Family in Psychosis: Recovering From Blaming. Lewis, Neuropsychological Deficit and Psychodynamic Defence Models of Schizophrenia: Towards an Integrated Psychotherapeutic Model. Part II: Global Perspectives on Psychotherapy for Psychoses. Killackey, Introduction to Part II. Larsen, Biological and Psychological Treatments for Psychosis: An Overdue Alliance? Herewini, New Zealand Maaori Conceptual Models Utilised Within Early Intervention Services. Phillips, Francey, Morrison, Bechdolf, Veith, Klosterkotter, Development of Psychotherapy in the Pre-psychotic Phase: Integration of Three International Approaches – Australia, Germany and UK. Sanyal, Integration of Psychotherapy in Concept Change Within a Culture – India. Part III: Integrating Psychotherapeutic Thinking and Practice into 'Real World' Settings. Miller, McCormack, Sevy, An Integrated Treatment Program for First-episode Schizophrenia. Berk, Macneil, Castle, Berk, The Importance of the Treatment Alliance in Bipolar Disorder. Geekie, Read, Fragmentation, Invalidation and Spirituality: Personal Experiences of Psychosis. Ethical, Research and Clinical Implications. Killackey, Krstev, Gleeson, The Role of National Guidelines in Integrating Psychological Interventions into Real-world Settings. Norman, Hassall, Mulder, Wentzell, Manchanda, Families Dealing with Psychosis: Working Together to Make Things Get Better. Woodhead, Therapeutic Work for Young People with First-episode Psychosis. Couchman, Systematically Speaking: Integrating Multi-family Group Work.
John F. M. Gleeson is a Clinical Psychologist and Associate Professor across the University of Melbourne and NorthWestern Mental Health.
Eóin Killackey is a Clinical Psychologist and Senior Research Fellow in the Department of Psychology, University of Melbourne and ORYGEN Research Centre.
Helen Krstev is a Psychologist with PACE at ORYGEN Youth Health, and works in private practice in Melbourne.
"This is a well organised, wide-ranging and quite inspiring book... Anyone who now thinks that psychosis is just for psychiatrists and medical treatment had better read this book and have their ideas shaken up." - John Rowan, BACP North London Magazine, Iss. 59, October 2008
"This book advocates the integration of psychological approaches into the treatment of psychoses. It is an important book to be strongly recommended both for trainees, to familiarise themselves with the literature, and for consultants in considering how to effect their integration within their current approach to psychosis." - Richard Lucas, British Journal of Psychiatry, Volume 194, January 2009
"Psychotherapy for the Psychoses is another important existential addition to the literature that explores a variety of different psychotherapeutic approaches to schizophrenia, providing encouragement, and a sophisticated instruction for practitioners in their work with psychotics." - Gregory M. Westlake, Journal of the Society for Existential Analysis, July 2010


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Vacations can be expensive, but vacations can also be cheap. I have a list of place I want to go to that I can’t afford yet, but I have the travel bug like so many others.
I live in the United States, which is an amazing place to live if you’re looking for quick, cheap and diverse destinations to visit. If you’re on the east coast you have the Appalachian Trail, beaches, great US history destinations, rivers, forests, and cities to visit each weekend. The Statue of Liberty in NY, the Liberty Bell in PA, a replica of the Mayflower in MA, Washington DC, Gettysburg VA, the Hunley in Charleston, SC… If you’re in the West, you have BLM land and National Parks that will make your jaw drop!
I made myself a promise a while back, that I would explore the US before I venture to the rest of the world. I wanted to be able to talk about the awesomeness of the United States to anyone I met in the world, to tell them about amazing slot canyons in Utah, the beauty of the Appalachian Trail, Niagara Falls, the redwoods in Yosemite, the culture of New Orleans, and some of the extremely random places throughout the country. Did you know there’s a little-Sweden in Kansas? or “The Danish capital of America” in California? CarHenge in Nebraska? This country if so jam packed of incredible places to see, most people think they need to spend $1k on a flight to Europe to see things worth while. There’s plenty of things within a weekend drive from where you live.
Why not explore your own country first, then when you visit other countries, you can talk about the amazing things we have here and give others suggestion on where to go when they come here. I bet if you tell them about the hidden gems away from the tourists in your country, they’ll do the same for you in their country.
I was craving an adventure and after a 5 minute discussion with a co-worker, we had made plans to go see Mount Rushmore. My coworker and her husband borrowed a pop up camper from family and we left early on Saturday morning. It’s about a 6 hour drive to get there and we came back by Sunday night. That might sound like a quick trip, but when you’re with friends, the drive there and back is part of the enjoyment of the trip, it’s not always about just the destination.
For instance… who doesn’t want to stop on the side of the road in the middle of no where for a little Oregon Trail throwback?
I had a blast, got to be with friends, see a beautiful area and a National Monument, have a camp fire, and have a mini escape.
Here was the total cost breakdown:
Gas: $166 Camping: $20 Park Entrance Fee: $10 Food: $30 Firewood: $5 ------------------ Total: $231
Split that 3 ways and it was $77/each… add another $10 on personal spending of non-communal items and I easily spent under $90 for a weekend getaway.
There’s no reason you have to pay for expensive flights or hotel rooms. If you don’t like camping, then go spend the weekend in a nearby city at a friend’s you haven’t seen in a while. Go pick a city you normally don’t get to and get a hotel room just outside the city in a suburb. Rent a cabin somewhere… there are plenty of inexpensive ways to do things, especially with friends. Not every vacation has to be an epic budget buster… and remember, the drive is part of the vacation, blast the music, tell stories, and don’t forget to stop at stuff that piques your interest or those signs that say: “Place of interest ahead” or “Scenic overlook”.
Enjoy the trip and be sure to share places you’ve gone, what you did, and how inexpensive you were able to do it in the comments below. You’ll help other readers get ideas and maybe gain some of your own from their comments.


OSU football journal: Blake Jarwin caps Cowboy career with Alamo Bowl touchdown
Facing third-and-2 from inside the Colorado 10-yard line on Thursday, Oklahoma State quarterback Mason Rudolph received the shotgun snap and tossed a short cross right to one of his senior Cowboy backs.
Blake Jarwin did the rest.
Jarwin, the former walk-on from Tuttle, hauled in the reception and stiff-armed a CU defensive back during his run to the end zone in the 38-8 Alamo Bowl victory. It marked the fifth and final touchdown of Jarwin's Cowboy career.
“One of those guys that should have been recruited (and) wasn't,” OSU coach Mike Gundy said. “He came in (and) we put him on scholarship. We're really (going) to miss him and Zac Veatch for what they bring to our offense. They're good receivers, tough. They're smart, understand our offense.”
Spencer responds to Rudolph/Washington return
The announcement that Rudolph and receiver James Washington will return for their senior seasons sent shock waves through college football last week. In the Cowboy locker room, players and coaches on offense are undoubtedly salivating at the potential for next year. But what about OSU defensive coordinator Glenn Spencer?
The man tasked with preparing the Cowboys' defense for game days once again must deal with two of the Big 12's most dynamic weapons in team scrimmage settings.
“I enjoy watching those guys, and I'm glad I get to see them in practice all spring,” Spencer said, then smiled. “I do think they need to rep some younger guys in spring, though. Those guys (Rudolph and Washington) have proven what they can do, right?”
- Related to this story
- Video: Alamo Bowl: Mission Accomplished OSU beats Colorado 38-8 (2016-12-30)
Flowers anticipates playmakers in Sterns' absence
The Alamo Bowl victory was Jordan Sterns' final game in a Cowboy uniform, which begs the question, who will step up into his large shoes at free safety next fall?
The most likely candidate would appear to be Kenneth Edison-McGruder, a junior next season who has excelled on special teams and as a reserve defender. The Houston native made four starts and tallied 40 tackles this year. Like Sterns, Edison-McGruder also has a hard-hitting mentality.
Strong safety Tre Flowers will return in 2017 at strong safety, and no matter who stands beside him in the defensive backfield, he expects continued success.
“It's what they want,” Flowers said. “Sterns has been here forever, now it's time to show up. I can't wait to see who takes his spot.”
Gundy on the idea that OSU's 11-straight bowl appearances provided a large benefit compared to Colorado's long postseason drought:
“They haven't been to a bowl in a while. It's different. These guys (OSU) understand how to handle themselves. I said that during the week. Colorado was thrilled to death to be in a bowl, their fans and everybody, the coaches. And they should be. … I'm guessing that we had an advantage based on we'd been there, we understand it. That could have helped us. I would not disagree with that.”


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Seniors across the country, including in California, are catching a big break on their out-of-pocket prescription drug costs thanks to the historic health care law pushed through by President Obama and Democrats in Congress last year, according to new data released today by the federal Centers for Medicare and Medicaid Services.
California seniors who are enrolled in Medicare's prescription drug benefit who hit the "donut hole' coverage gap received a 50 percent discount on out-of-pocket prescription drug costs in 2011, saving nearly 55,000 California seniors a collective $30 million since January. Nationwide, nearly 500,000 seniors on Medicare benefited from the new provision, saving $260 million collectively since January.
Rep. George Miller (D-Martinez), who co-authored the health care law, known as the Affordable Care Act, praised the new data.
"Seniors are catching a big break on the cost of their prescription drugs thanks to the health reforms that we passed last year," Miller said. "As more and more people reach the feared donut hole this year, we'll see even more seniors directly benefiting from this law.
"The health reform law is having a positive impact on more and more people each and every day, seniors and non-seniors alike, but Republicans in Congress continue fight it. First they voted to repeal the health care law, which would wipe out these new drug cost savings. Then they voted to end Medicare and add thousands of dollars in out-of-pocket expenses to people who enroll in Medicare. Their votes are bad for seniors and bad for the country."
On April 15, House Republicans passed a budget that would end the guarantee of Medicare. Their budget plan would raise the cost of prescription drug costs for seniors, by repealing the health reform law provision that provided the 50% discount for brand-name drugs for seniors in the "donut hole' coverage gap and that would close the "donut hole' altogether by 2020. In addition, the non-partisan Congressional Budget office found that the budget plan would more than double the typical senior's out-of-pocket health care spending beginning in the year 2022, compared to what their costs would be under traditional Medicare -- increasing their out-of-pocket costs by more than $6,000 per year.


A woman whose back garden was at the centre of an unexploded bomb scare that prompted one of the biggest evacuations since the Second World War has described the ordeal as an "absolute nightmare".
Speaking to Sky News, Natalie Jary said she wanted to say "sorry" to the community of Keyham where she lives in Plymouth.
The 500kg wartime explosive was unearthed by her father as he dug foundations for a rear extension to her home in St Michael Avenue.
The discovery on Tuesday prompted a major emergency, with the munition assessed as posing a significant risk to public safety.
A 300-metre cordon was put in place around the site, affecting 1,219 properties and an estimated 3,250 people.
About 30 of the armed forces' most experienced bomb disposal specialists worked around the clock to assess the condition of the device and decide how best to deal with it.
On Friday, a military convoy carried the unexploded bomb on the back of a truck from the garden through a deserted residential area to Torpoint Ferry slipway, where it was taken out to sea and later detonated.
Ms Jary described the incident as an "absolute nightmare".
She said: "[This is the] last thing I thought would happen doing an extension.
"I want to say thank you to the street and thank you to police and council.
"I wanted to say sorry to Keyham."
She added her insurance would cover the damage to the garden.
Defence Secretary Grant Shapps praised the "bravery and fortitude" of personnel involved in the "highly complex operation" and the "patience and cooperation" of members of the public.
He said: "I would like to express my thanks to all our personnel involved in this highly complex operation, who worked both night and day this week to keep the public safe and minimise the risk of damage, as well as the public for their patience and cooperation.
"The success of this operation is a testament to the level of skill and expertise across our armed forces, as well as the bravery and fortitude of our personnel when faced with high-risk situations and working under extreme pressure."
Plymouth City Council leader Tudor Evans said: "I think it is fair to say that the last few days will go down in history for Plymouth."


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Having the right point-of-sale system is paramount to any business success. While other factors like the type of POS system, cost, limitations and features are all important to consider, it is often very easy to overlook one of the most crucial aspects of a POS system: security.
Getting to understand POS security isn’t something for the faint hearted. Not only are there complex regulations, but keeping up with fees and charges is another beast on its own. If you are a small business owner, having to deal with POS security is one necessary evil that is if of course you’d love to enjoy the benefits and convenience of accepting credit cards.
The following can help you.
- Is the Point-Of-Sale System PCI Compliant?
When choosing a new POS system, the first thing to look at is whether it meets the necessary regulations and requirements for accepting credit cards. For example, as of October 2015, new credit card regulations state that merchants are required to have EMV chip enabled POS systems.
Every business that processes credit cards for payments of goods and or services is required to be PCI compliant.
- Updating and Maintaining Purchased Technology
As the world evolves so does technology, and at a rapid pace. The same is true for credit card processing systems. When choosing a POS system, find out from your provider about the maintenance schedule. Having an outdated system in place will put customer credit cards and your business at risk for security breaches.
If you can’t purchase technology (IT or security), then make sure you maintain the system by installing anti-malware and antivirus software. Even the most advanced and up-to-date firewall is useless if it uses default login and password.
In addition to making sure that your POS software is updated, it is also important to regularly check the ever changing PCI compliance regulations and rules to make sure your system meets them. For example, MasterCard and Visa change their PCI regulations and rules at least once a year.
- Isolate your Point-Of- Sale Systems
When you choose a new POS system, it is also worth considering whether you’ll keep the system entirely separate from your business technology and systems.
In general, POS systems tend to be the weakest link in the lineup and vulnerable systems often run on a standard operating system, making them easily prone to attacks when exposed to malware delivery channels like browsers, POS management system that is compromised, patch system or even worse from someone within the organization.
- Encryption Services and Fees
While security is an important aspect in electronic payment processing, it is crucial to understand the types of encryption options available for your POS system.
Find out from the POS vendor if the POS system will require a separate encryption service. Also bear in mind that your encryption may have a monthly fee. Find out as well whether they offer a POS system that comes with an end-to-end encryption, as this will simplify the process, saving you both time and money.


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Falco 48V Lithium Battery (Charger + Holder Included) - The pack merely weighs 3.3 kg (7.2 lbs.) and it delivers 556Wh of energy (48V, 11.6Ah). The 48V battery pack has a number of primary as well as secondary protections. The packs use Lithium Ion Rechargeable battery cells from Panasonic.
EcoSpeed 1000W Middrive w/48V Battery - The KMX EcoSpeed Mid-Drive will change your riding experience forever. Not only can you ride faster but longer than ever before at great speeds. Fly to and from work at no cost, take long rides with ease, and mostly enjoy the time spent on your EcoSpeed trike.
Avid BB7 Front Disc Brake Kit (pair) - This kit includes everything you need to upgrade your trike's brake system to the best mechanical disc brake system available. Perfect for for any home builds.
One Hand Brake Control Lever - LEFT Side Dual Pull - Do you need to operate all of the controls with one hand? Do you prefer to have no brake-steer? If you answered yes to either question, order this dual control brake lever! It's a single lever that operates both brakes and is compatible with all trikes we currently sell.
-The Double Barrel lever pulls two long-pull brakes simultaneously
-Forged aluminum lever and cast aluminum bracket
Utah Trikes Rack with Integrated Fender for Annihilator - Our adjustable rack fits the Annihilator perfectly. With this option we mount the fender directly to the rack to eliminate the traditional wire stays. This makes the fender much more rigid and secure and keeps the rack height as low as possible.

domain: hobby


Aquatherm Fleece Mens Long Sleeve Top
Aquatherm Fleece Mens Long Sleeved Top keeps the base layer and torso warm and dry whilst offering great freedom of movement. For the coldest climates, a soft warm 3mm fleece is bonded onto a durable, stretchy, polyurethane outer surface, allowing the wearer optimum movement and maximum warmth, without the restrictions of layering, typical of bulky fabrics. Fully taped and waterproofed external seams for maximum strength. Can be worn on its own, or for extra warmth as a thermal booster layer underneath a wetsuit, semi dry suit or cag. AquaFleece is best worn close fitting around the neck, arm and waist and loosely comfortable around the upper body. Options: 30cm front zip (for venting)£4.00 extra 50cm back zip (for ease of getting on and off) £4.00 extra.
I think this is the best bit of paddling kit that I own. Unless the conditions are really bad, in cool and/or wet conditions I would choose this over my paddle cag every time. It's warm, comfortable and feels free.
Pretty good product 27/03/2021
By Ben Jackson
I've had this product for about a year and used quite heavily during winter times. kept me super warm and reasonably dry.
Only down side was that the wrists are a bit of a squeeze as the wrist seal bit isn't very flexible and doesn't mould to the side of the wrist so you do get some water zeeping in. how ever with the aquatherm fleece lining inside it warms up pretty fast. Good price for the quality of the top.
Item used for kayking and SUP paddle boarding.
Excellent versatile top, very warm! 12/02/2021
By Thomas Phillips
Amazing warmth from such a light top. Quite tight fitting, but you can return if wrong size or get made to measure. The fabric is very tough but soft lining is very comfortable


Objectives of the service
In Germany, musculoskeletal diseases account for more than 20% of all sick days, while 40% of all individuals are chronically impaired. And so far, there is no effective monitoring and support system to guide remote physiotherapy exercises. Patients thus have therapy time that is too short, high treatment costs, and low motivation, and half of the rehabilitation processes are left incomplete. KINFINITY offers a smart bandage solution to relieve and support physiotherapists and motivate patients to regularly carry out their exercises at home. KINFINITY’s simBa enables remote physiotherapy treatment, no matter where the patients are. It is highly personalized, reduces costs, and motivates the patient for their therapy, resulting in an improved quality of life.
Users and their needs
KINFINITY’s user segment is divided into four groups: Sports tech enthusiasts, physiotherapists, patients, and health insurance companies, in Germany and Europe.
Sports tech enthusiasts need a rehabilitation solution that allows them to perform recovery exercises without the need for an in-person consultation.
COVID-19 greatly contributed to physiotherapy being offered online. As far as online physiotherapists are concerned, they need a solution that helps accurately monitor the movements of patients and track them regularly without having to consult them physically. On the other hand, offline physiotherapists are looking for a solution that helps track the progress of patients performing home exercises and gives them feedback without having to be always present.
Health insurance companies need a solution that helps them enable faster recovery of the patients while ensuring full recovery to avoid reinjuries and keep the costs for recovery low.
Patients, i.e., people who have been prescribed physiotherapy or those living in remote areas, need a solution that can accurately track and monitor their home recovery exercises without the necessity to always go to their physical therapist’s office personally.
Service/ system concept
simBa includes the smart bandage as well as the KINFINITY app as the central point of the physiotherapy ecosystem, which uses an artificial intelligence algorithm to track the motion of the patient in real-time.
During physiotherapy sessions with the therapist, patients wear KINFINITY’s smart bandage, which automatically learns the ideal path of required movements and the patient's individual anatomy. The bandage connects to the patient's smartphone, enabling real-time monitoring of movements at home. The advanced AI algorithms of the KINFINITY app compare the executed movement with the referenced one during physiotherapy sessions and provide real-time feedback on incorrect movements. Furthermore, new exercises can be recorded directly by the physiotherapist, like recording an audio track; record -> make the movement -> stop. This allows a lot of flexibility for the patient.
The recorded data from each session is presented to the user in a comprehensible manner, along with an evaluation of its quality. This data can also be directly sent to the physiotherapist, enabling a real-time assessment of the patient's exercises and suggestions for improvements without physical contact.
Space Added Value
A majority of KINFINITY’s team members are former employees of the German Aerospace Center Institute of Robotics and Mechatronics. As a Human Spaceflight technology, they developed sensors to track the motions of astronauts during their space flight to control robots from afar to allow teleoperation of robots from space on the surface of the ground (for example, the moon, Mars), which enables complex technical tasks to be performed on the surface while keeping astronauts safe in the orbit.
This same technology that is used in these space operations is used in KINFINITY’s simBa. The stringent quality and reliability requirements of the space sector ensure that simBa’s sensors are always delivering the most accurate results and capturing the movements of the user with no error. Currently, there exists no solution in the physiotherapy industry that utilizes technology with such stringent quality requirements in its products. With these novel sensors, KINFINITY brings technology from space back to Earth!
KINFINITY successfully completed a 9-month clinical trial with SESCAM hospital in Spain and the result of the study was higher adherence of the patients to the exercise regime, low errors when performing the exercises, and improved range of motion (ROM). KINFINITY is also in negotiations with a medical technology company for a potential collaboration focusing on knee rehabilitation. KINFINITY also has 3 signed letters of intent from 2 physiotherapists based in Germany and France.


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Gold Price Analysis: XAU/USD set to test $1800 behind Fed’s dovish decision
Gold superior from the lows and trades around $1,780, eyeing a company ruin above $1800. Meanwhile, US GDP is in consciousness on Thursday.
XAU/USD to upward thrust above $1800 on US T-bond yields shifting beneath 1.55%
Gold is constructing on Fed-caused turnaround this Thursday, gaining extra gain from US President Joe Biden’s push for a $1.8 trillion spending package. Expectations of ongoing coverage guide from the authorities and the important financial institution provide a much-wished raise to the bulls.
Heading right into a flurry of vital US financial records, gold has entered a section of upside consolidation, because the US greenback tries a jump throughout the board. However, gold is probably to renew its uptrend because the dollar keeps to experience the pull of gravity amid dovish Fed expectations.


Ian Austen on KCRW
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Employment and Civil Rights
Employment and civil rights laws are designed to ensure that individual rights are protected in the workplace and in society at large. In the workplace, such laws prohibit an employer from firing or refusing to hire someone because of illegal grounds such as discrimination on the basis of race, gender, religion, national origin, age, disability, or other protected status. The law also prohibits harassment in the workplace or retaliation based on these illegal grounds.
Our Employment Group is well qualified by training and experience to address such issues. Our attorneys represent employers and claimants in employment discrimination and civil rights cases, and in labor matters, in the courts of Pennsylvania and New Jersey, and in administrative proceedings. We have handled discrimination claims based on race, age, gender, disability, and religion. We also have experience with employment matters involving sexual harassment claims, wrongful termination and retaliation claims, ERISA benefits claims, whistle blower law violations, wage and hour statutes, the federal Worker Adjustment and Retraining Notification (WARN) Act, and the Family and Medical Leave Act (FMLA).
We have further provided substantial work on behalf of employers and employees in negotiating severance/separation agreements, counseling, assisting in administering terminations and layoffs, and other employment related issues. Our attorneys are proactive and seek to ensure that employers have the proper policies and procedures in place for purposes of legal compliance. In this regard, our attorneys can assist in the preparation of employee handbooks and related promulgation.


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On May 27th, in conjunction with the Denver Police Department, ADL’s Mountain States Regional Office presented a day-long training for over 100 law enforcement officials throughout Colorado. Included were seminars on Colorado’s Hate Crime Statute, Left-Wing and Single Issue Extremists, Right Wing Extremists and Anti-Government hate groups. The seminar on hate crimes offered instruction on the special nature of hate crimes, the legal and constitutional framework in which federal and state hate crime statutes operate and how to perform investigative and enforcement duties in a way that reassures the victims and helps alleviate community tensions and fear.
The seminar on Left-Wing and Single Issue Extremists offered an introduction to the Extreme Animal Rights and Environmental Movements and included the goals, tactics and trends of these movements. The seminars on Right Wing Extremists and Anti-Government hate groups covered the historical contexts, beliefs, ideologies and actions of those movements. ADL is a nationally recognized expert in monitoring and exposing the activities of organized hate groups and crafting legal and legislative responses to hate crimes. The Mountain States Regional Office regularly offers training programs to law enforcement and other groups, in addition to publications and resources that were created specifically for law enforcement professionals.

domain: sociology


Islamabad, Jan 28(ANI): Pakistan has threatened to activate a new nuclear arms race in South Asia after the United States supported a move that Islamabad claims will allow India to further expand its weapons programme.
Islamabad believes that Washington's decision to support Indian membership of the Nuclear Suppliers' Group following an agreement to help India develop its civil nuclear power industry, will help New Delhi to further increase its nuclear weapon arsenal.
Pakistan's military leadership is determined to maintain the current ratio of Indian to Pakistani nuclear warheads, and is already concerned that India is pulling ahead following the 2009 launch of a domestically produced nuclear submarine, The Telegraph reports.
Pakistan's Permanent Representative to the Conference on Disarmament told delegates this week that Washington's decision in this regard would "destabilise the security environment in South Asia."
"Membership of the NSG will enable our neighbour to further expand upon its nuclear co-operation agreements and enhance its nuclear weapons and delivery capability. As a consequence, Pakistan will be forced to take measures to ensure the credibility of its deterrence," Zamir Akram told the conference.
Pakistan's National Command Authority, headed by Prime Minister Yousuf Raza Gilani and a retired army general, had voiced its concern on the implications of the new civil nuclear co-operation deal between India and the US for Pakistan's security, Akram added.
Pakistan also opposed Washington's decision to support Indian membership of the Missile Technology Control Regime, the Australia Group and the Wassenaar Arrangement. (ANI)


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You can find more on Valentine coloring pages including pictures you can download, print and color for free, on this blog that treats toe subject of coloring pages. Besides sheets with Disney characters, you’ll also find there many other types of coloring pictures and books, all available free of charge for all visitors. How many times have you simply sat there with a box of crayons or coloring pencils and a coloring book or coloring pages and just enjoyed yourself for a little while? It really is not that surprising that there are as many adults that really love coloring as there are children that love this activity. Too many times adults sit there and hide the fact that they still like or love to color as much as their kids, or the kids in their lives, do. Think about this and answer this question if you possibly can; what is the matter with saying that you like to color on SpongeBob coloring pages?
Importance of Alphabet Coloring Pages: Kids actually enjoy learning from an early age, only you should know how to teach them. Such alphabet coloring sheets make studies lot easier and lighter for them. They learn from the very beginning to take the studies like games and build strong base for learning things easily. Lots of children at higher classes cannot handle the pressure of studies because they don`t know the exact process or method of learning because their preschool learning had been very much mechanical and dull.
You might have heard of alphabet color pages that are used to teach preschool kids and toddlers. They are taught alphabets and relate them with their surroundings. Similarly the Biblical coloring pages are there too for getting direct print from your computer and show them to your children. The world of web has been really delightful in these matters. You can find ready made color pages in hundreds of styles and colors that also contain Biblical themes, stories like Noah’s Ark, the Whale, miracles of Jesus, about the birth of baby Jesus, Mother Mary, Easter, Gift of Magi and alike. The use of these coloring sheets is perfect to teach preschool children the values and morals of Christianity, the true meaning of religion and how to become pious.
These coloring pages happen to be for the younger crowd and love to have a look at the color selection pages of stories advised to them by mummy, grandmother, father or other people. These color pages have finest quality print and perfect drawings to impart the impression of Jesus, his wonderful things, his love for children, his soft spoken words, love for enemies, prayers for a lot of and taking the burden of bad thing of all mortals. The color pages are constantly produced by artists to provide more aesthetic and realistic look from the pictures. Every artist will try his label best to develop variations and endeavor to go over as many more interesting characters and drawings to related to Biblical characters. Such extensive design and images of Jesus with children, people, the family pets, and other characters help children learn the teachings of Bible fast and also they imbibe in them the best traits of humans.


This course is aimed at beginner to intermediate music makes are artists that want to learn how to record, edit and mix their own songs
Music Makers and Artists with basic music production skills that want to improve them
Music Composers, Producers, Beatmakers, Songwriters and anyone making music
What Will You Learn?
- At the end of this course, you’ll be able to find your way around your DAW
- Know how to record your audio and MIDI tracks.
- Plus, you'll know how to add and edit effects
- Improve your mix and mastering of your songs.
Introduction to Music Production
Music Setup Guide
Using Multiple Takes and Audio Comping
Setting Up Your Tracks
Learn the EQ Effect
Live Demo on EQing
EQ in Practice


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Natchez Trace State Park and Forest Campground Professional Guide
Detailed Trail Description from our Guidebook
"The Natchez Trace was an old travel-and-trade route used by Indians and settlers. A western branch of this path that once connected Nashville, Tennessee and Natchez, Mississippi passes through this park, where today visitors hike, fish, swim, ride horses, and camp on 48,000 acres of attractive forest that was once among the most abused land in the state.
Subsequent conservation, which begun in the 1930s, has rendered the Natchez an inviting destination. Miles of hiking trails here traverse woodlands, fields, streams, and shorelines. Mountain bikers have miles and miles of backcountry roads and paths to pedal. Park stables offer trail rides too."

domain: geography


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September Project Life Album - Part I
As the year has gone, I've worried each month about being able to try something fun and new with this project. That was pretty much my main goal for starting this monthly albums this past January. I was kind of tired with the normal 12x12 Project Life pages, but still wanted to document our days and our memories.
I love creating mini albums, so it was pretty much an easy decision when it came to creating albums every month. And every month I stress about the size and how to do something "new", and then every month I fall in love with a different sized/type of album.
This month, I chose to use a Travelers Notebook for our memory keeping. I have a few of these pretties, but mainly have used them for lists, notes, etc. I hadn't merged the two yet. Now I am SO glad I did.
The Travelers Notebook is the perfect little "album" for creating a mini album. The base pages are white and clean and are already bound together (and super score that you can create your own inserts and pages).
I'm over on the Studio Calico blog today sharing a look at our September in the Travelers Notebook. This month is by far my favorite. I love how compact and simple this album - how the photos take the center stage and really pop from those white pages.
In this month's video, I talk about some of my different tips and tricks for working with the Travelers Notebook, so be sure to check it out!! Thanks so much for letting me share these monthly albums with you! As the year comes to a close, I'm just so grateful that I have these books and all of these memories recorded.


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Publisher: Simon & Schuster BFYR
Page Count: 391 pages
Series: Hush, Hush #1
A SACRED OATH
A FALLEN ANGEL
A FORBIDDEN LOVE
Romance was not part of Nora Grey's plan. She's never been particularly attracted to the boys at her school, no matter how hard her best friend, Vee, pushes them at her. Not until Patch comes along. With his easy smile and eyes that seem to see inside her, Patch draws Nora to him against her better judgment.
But after a series of terrifying encounters, Nora's not sure whom to trust. Patch seems to be everywhere she is and seems to know more about her than her closest friends. She can't decide whether she should fall into his arms or run and hide. And when she tries to seek some answers, she finds herself near a truth that is way more unsettling than anything Patch makes her feel.
For she is right in the middle of an ancient battle between the immortal and those that have fallen - and, when it comes to choosing sides, the wrong choice will cost Nora her life.
Well, it took me two years to finally write a review for this series.
Nora Grey is a sixteen year old girl who is a high school sophomore. She lives with her single, widowed mother. She has a mundane life until one day she meets her biology partner Patch. Patch is a very mysterious, hot, and arrogant person. Like any person would, Nora is attracted to him but still little wary of him.
Ever since Patch entered Nora’s life, strange events starts to happen. Nora thinks that Patch might have something to do with it so she's conflicted to trust him or not. When she finally discovers Patch’s secret, Nora is in a helluva trouble.
For me, Patch is like an emotional roller coaster. I love how self sacrificing he is. I love the storyline in general. It made me want to find out more about Nora and Patch. They are likable characters but in all honestly, sure they sometime frustrates you. One character in particular I just didn't like and it was Vee. She'd basically the only friend that Nora has but I just hated her.
Nora somehow reminds me of Clary from the Mortal Instruments series by Cassandra Clare but a lot worse. It's just the things she does where I and many others just disagree with.
There was some parts that are confusing but this book played out really good.