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(TheLastPatriotNews.com) – A remarkable admission that Donald Trump’s quest to reclaim the White House is likely to succeed has come from an unlikely source as a leftist propaganda pillar. CNN’s political director has stated new poll results contradict other 2024 GOP candidates claiming the former president can’t win.
CNN Political Director David Chalian recently cast doubt on the narrative promoted by some Republican nomination bidders that Trump is unelectable.
Chalian provided an analysis of a new CNN poll, conducted in partnership with the University of New Hampshire, which shows Trump leading his Republican competitors among New Hampshire voters.
Notably, former South Carolina Governor Nikki Haley is trailing Trump by 22%, securing 20% of the vote, while both Florida Governor Ron DeSantis and businessman Vivek Ramaswamy are registering in the single digits.
Chalian further dissected the poll results, revealing that 52% of respondents have firmly decided on their candidate, 35% are leaning toward a candidate, and only 12% remain undecided. He emphasized the strong commitment of Trump’s supporters.
“But if you add in Trump supporters here, just take a look. Those who say Donald Trump is their choice in this primary, 83%… say they are solidly locked in,” the CNN analyst said.
“That is the stickiness of his support. Eleven percent of Trump supporters are leaning to someone, they consider themselves sort of leaners, five percent still deciding. And as you know, one of the main arguments that we’re hearing from candidates not named Trump is that he can’t win and that argument is falling on deaf ears with this New Hampshire Republican primary electorate,” he elaborated.
Chalian also pointed out a noticeable shift in perceptions of Trump’s electability.
“Look at this movement. Donald Trump back in September, 51% of likely Republican primary voters said he had the best chance of winning a general election. That’s now up to 57%. So he’s up six points on electability. It’s not an argument that people are hearing that Donald Trump can’t win the general election,” he explained.
Meanwhile, Haley’s support has surged, as indicated by an Emerson College poll placing her in second place in New Hampshire with a 14-point jump. Trump leads with 49% in this poll.
Additionally, a new Quinnipiac poll demonstrates Trump’s competitive edge over President Joe Biden, showing him leading by two points, marking a first for this particular poll.


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News hotlines: 08111813019, 08025868561
Oil prices fell on Monday as increased drilling in the United States pointed to more output, raising concerns about a return of oversupply.
Analysts say if the rise by US drilling continues, glut will emerge, causing further drop in global oil price which will impact on Nigerian economy and the deepening foreign reserves now at over $46bn.
U.S. West Texas Intermediate (WTI) crude futures were at $62.02 a barrel at 0350 GMT, down 32 cents, or 0.5 percent, from their previous close. Brent crude futures were at $65.85 per barrel, down 36 cents, or 0.5 percent. Monday’s price falls in part reversed increases last Friday, which came on concerns over tensions in the Middle East. On a simple supply versus demand basis, however, oil markets are facing the possibility of a renewed glut after being in a slight deficit for much of last year. U.S. drillers added four oil rigs in the week to March 16, bringing the total count to 800, the weekly Baker Hughes drilling report said on Friday. “Surging U.S. production will hamper exponential growth in crude oil prices,” Singapore-based brokerage Phillip Futures said on Monday. The U.S. rig count, an early indicator of future output, is much higher than a year ago as energy companies have boosted spending. Thanks to the high drilling activity, U.S. crude oil production has risen by more than a fifth since mid-2016, to 10.38 million barrels per day (bpd), pushing it past top exporter Saudi Arabia.

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Mona Ghandi, assistant professor in the School of Design and Construction, and her team in the Morphogenesis Lab have received a World Architecture Award from World Architecture Community for a project that uses artificial intelligence and wearable technology to respond to people’s emotions.
The award highlights and recognizes projects that have the potential to inspire questions about contemporary architectural discourse, according to their website.
The award was for Ghandi’s lab work, “Wisteria: Architecture as an Embodiment of Human Emotion.” Wisteria is an adaptive installation that performs real-time responses to people’s emotions, based on biological and neurological data. In the project, people enter a space filled with a forest of cylindrical fabric shrouds that are made of a programmable material called a shape memory alloy that moves in a breathing rhythm. The project integrates artificial intelligence (AI), wearable technology, sensory environments, and adaptive architecture, allowing visitors to change the color and form of the installation using their brain and emotions.
“Wisteria is an extension of its visitors’ mind and body,” said Ghandi.
With its use of affective computing or “emotion AI,” the project could someday lead to therapies for people who have difficulty communicating their emotions, such as those with autism, PTSD, or mental disabilities.
“This is a very competitive award that architects from all around the world compete for annually,” said Ryan Smith, director of the School of Design and Construction. “Winning this award shows this project’s importance not only for its impact on the architectural community but also for its innovations in improving human wellbeing through the use of artificial intelligence and adaptive spaces.”
With WSU since 2016, Ghandi’s research focuses on intelligent architecture, examining the role of AI, machine learning, robotics, and adaptive architecture in improving well-being in buildings. Her research aims to create cyber-physical adaptive spaces that can respond to the user’s physiological and psychological needs based on biological and neurological data in real-time. Her focus is on smart systems that create adaptive and user-oriented spaces using affective computing. Through artificial intelligence, she seeks to create spaces that can learn from the user’s behavioral patterns in real-time, enhance environmental quality, reduce user’s anxiety and depression, and promote more flexible, human-centered designs. Ghandi has applied this approach in correlation with biofeedback data, aspiring to make buildings more attuned to the psychology of their occupants.
Video of the project:


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Discover the land of Israel with its history, religion, and outstanding scenery. Visit the ancient city of Jerusalem, float on the Dead Sea, or enjoy the nightlife of Tel Aviv. Cross over to Jordan to visit the amazing Petra, one of the Seven Wonders of the World. Amman, Jerash and mystical Mount Nebo are not to be missed!
- Return airport transfers
- English speaking local guides
- 10 night accommodation in double occupancy
- Meals: 10 breakfasts
- Visits and excursions as per itinerary in a shared vehicle or bus
Not included • International airfare & airport taxes • Gratuities to hotel personnel, guides and drivers • Beverages • Optional excursions • VISA for JORDAN • Border tax for Israel/Jordan (approx… USD60, paid at border crossings)

domain: geography


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Scuba Diver and the Hammerhead Pug Costume
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Scuba Diver and the Hammerhead Pug
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This homemade costume for boys entered our 2014 Halloween Costume Contest.
A word from Laura, the 'Scuba Diver and the Hammerhead Pug' costume creator:
The idea came from the Ocearch shark tracker app that my son, Bryson loves. He loves sharks so I decided to make him into a scuba diver. From there I decided I could turn my wagon into a shark tank. I used Spray painted Coke bottles and duck tape for the air tanks and hardware store tubing and plumbing pipes for the mouth piece. For the shark tank I used a dollar store table cloth and gift wrap.

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ORIGINAL RESEARCH article
Sec. Infectious Diseases: Pathogenesis and Therapy
Volume 5 - 2018 | https://doi.org/10.3389/fmed.2018.00225
Virulence Factors and Antibiotic Resistance of Klebsiella pneumoniae Strains Isolated From Neonates With Sepsis
- 1Department of Children Infectious Diseases, Kazan State Medical University, Kazan, Russia
- 2Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russia
- 3The Neonatal Intensive Care Unit, City Children's Clinical Hospital N1, Kazan, Russia
- 4Republican Clinical Infectious Diseases Hospital, Kazan, Russia
Introduction: Klebsiella pneumoniae is one of the most important infectious agents in neonates. There are “classic” and hypervirulent strains of K. pneumoniae. The “classic” non-virulent strain of K. pneumoniae, producing extended-spectrum beta-lactamases (ESBLs), is associated with nosocomial infections. Hypervirulent K. pneumoniae strains are associated with invasive infections in previously healthy adult people, and most of them exhibit antimicrobial susceptibility. The role of virulent strains of K. pneumoniae (including hv-KP) in neonatal infections is unknown. The aim of the study was the assessment of the impact of virulence factors and antibiotic resistance of K. pneumoniae strains on clinical features and outcomes of neonatal infection.
Materials and Methods: Two groups of infants were enrolled. The first group consisted of 10 neonates with sepsis caused by K. pneumoniae. The second group consisted of 10 neonates with urinary tract infection (UTI) caused by K. pneumoniae. We investigated the susceptibility of K. pneumoniae isolates to antibiotics, the ability of the microorganism to produce ESBL, and virulence factors, including the rmpA gene, aerobactin, and colibactin genes. In neonates with sepsis, we investigated K. pneumoniae isolates, which was taken from the blood, in neonates with UTI—from the urine.
Results: In neonates with sepsis testing of K. pneumoniae isolates for ESBL production was positive in 60% of cases, in neonates with UTI—in 40% of cases. All blood and urine ESBL producing K. pneumoniae isolates were resistant to ampicillins, including protected ones, and third-generation cephalosporins. At the same time, these isolates were sensitive to meropenem, amikacin, and ciprofloxacin. The rmpA gene was detected in four blood, and three urine K. pneumoniae isolates. In neonates with sepsis rmpA gene in two cases was detected in ESBL-producing K. pneumoniae isolates. They were infants with meningitis, and both cases were fatal. In the group of infants with UTI, the rmpA gene was detected only in K. pneumoniae isolates not producing ESBL. Aerobactin and colibactin genes were detected in two neonates with sepsis and in three neonates with UTI. In all cases, aerobactin and colibactin genes were detected only in rmpA-positive K. pneumoniae isolates. Out of three fatal outcomes, two cases were caused by hv-KP producing ESBL.
Conclusion: The prevalence of virulent strains of K. pneumoniae among neonates with sepsis and other neonatal infection is higher than we think. The most severe forms of neonatal sepsis with an unfavorable outcome in our study were due to virulent strains of K. pneumoniae.
Klebsiella pneumoniae is one of the leading causes of neonatal sepsis (NS) (1, 2). This microorganism accounts for NS in 4–9% of cases in developed countries, and 16–28% in developing countries (3–6). There are “classic” and hypervirulent strains of K. pneumoniae (7). “Classic” non-virulent K. pneumoniae (c-KP) strains are usually associated with pneumonia, urinary tract infection, nosocomial infections, and neonatal sepsis in immunocompromised patients (8). C-KP can cause NS outbreaks in hospitals and ICU (9, 10). C-KP strains have recently gained notoriety due to their propensity to acquire antimicrobial resistance. Within the last few decades, extended-spectrum β-lactamase (ESBL)-positive K. pneumoniae isolates have been recovered worldwide, especially in intensive care units (ICU) (11). The prevalence of ESBL-producing strains of K. pneumoniae is 23% in the USA, and up to 85–100% in some European countries (11). Hypervirulent strains of K. pneumoniae (hv-KP) were first recognized in Taiwan in the last twentieth century and caused liver abscesses, meningitis, and endophthalmitis in previously healthy adult patients (12–14). Currently, hv-KP strains are being spread in different parts of the world (15, 16). High virulence of hv-KP is associated mainly with enhanced capsule production, that can be triggered by a regulator of the mucoid phenotype (rmpA) gene and mucoviscosity-associated gene A (magA) (7, 17). In addition to c-KP and hv-KP, in recent years the third type of K. pneumoniae was detected, which characterized by a combination of antibiotic resistance and hypervirulence (16, 18, 19). The prevalence of antibiotic resistance in hv-KP isolates is rare compared with the high prevalence of antibiotic resistant c-KP isolates (20). A report in 2016 showed that in China 12.6% of hv-KP isolates from several invasive infections produced ESBL (21). The role of virulent strains of K. pneumoniae (including hv-KP) in neonatal infections is unknown. We hypothesized that virulent determinants of K. pneumoniae might affect clinical features and outcomes on neonatal infection. We assume that virulent strains of K. pneumoniae in neonates can lead to the development of the most severe forms of neonatal infection (purulent meningitis and sepsis with one or more foci of infection). C-KP in neonates is associated mainly with prematurity, the immaturity of the immune system, prolonged staying in the intensive care unit (ICU), mechanical ventilation, using intravenous or urinary catheters (1). Therefore, the main clinical manifestations of neonatal infection caused by c-KP can be pneumonia, urinary tract infection, and septicemia.
The aim of the study was the assessment of the impact of virulence factors and antibiotic resistance of K. pneumoniae strains on clinical features and outcomes of neonatal infection.
Materials and Methods
This study was conducted over a period of 18 months between May 2015 and October 2016. Two groups of neonates were enrolled. The first group consisted of 10 neonates with culture-proven sepsis, caused by K. pneumoniae. Neonates with sepsis were admitted to the Neonatal Intensive Care Unit (NICU) of the City Children's Clinical Hospital N1 in Kazan. During this period, the diagnosis of culture proven sepsis was established for 28 neonates admitted in NICU of this hospital. In 14 cases (50%), neonatal sepsis was caused by Staphylococcus spp., in 13 cases (46%)—by K. pneumoniae, and one case was due to Candida spp. Seven neonates have died. Most of them (six neonates, 86%) were neonates with sepsis caused by K. pneumoniae. In accordance with the Report of the Expert Meeting on Neonatal and Pediatric Sepsis (8 June 2010, EMA, London) (22), sepsis was defined as the presence of at least two clinical symptoms and at least two laboratory signs in presence of or as a result of a suspected or proven infection (positive blood culture). The clinical symptoms are (1) body temperature instability; (2) cardiovascular instability; (3) skin and subcutaneous lesions such as petechial rash or sclerema; (4) apnoea or increased oxygen requirement, or requirement for ventilation support; (5) feeding intolerance or abdominal distension; and (6) irritability, lethargy, or hypotonia. Its laboratory signs are (1) a white blood cell (WBC) count of <4 or >20 × 109 cells/L; (2) an immature to total neutrophil ratio (I/T) of >0.2; (3) a platelet count of <100 × 109/L; (4) C-reactive protein (CRP) levels of >15 mg/dL; (5) blood glucose values of >180 mg/dL or hypoglycemia (<40 mg/dL) confirmed at least twice; and (6) metabolic acidosis as characterized by a base excess (BE) of ≤10 mmol/L. Blood cultures of all 10 neonates included in the study were positive for K. pneumoniae. The second group (comparison group) consisted of 10 neonates with urinary tract infection (UTI). The criteria for inclusion of neonates in this group were leukocyturia (>10 leukocytes/mL) and bacteriuria (>105 colony-forming units/mL). Four out of ten infants had a fever and were admitted to the hospital, another six were outpatient infants and had no any clinical symptoms. From the urine of all infants was isolated K. pneumoniae.
We studied the antibiotic susceptibility of K. pneumoniae, its ability to produce ESBL, and its virulence factors including rmpA, aerobactin, and colibactin genes. A distinctive feature of hv-KP is its hypermucoviscous phenotype.
The Ethics Committee of the City children's hospital approved this study, the written informed consent obtained from the parents following the principles authorized under this protocol (the Federal Law N323-FL dated on 21.11. 2011 “On Protection of Health of the Citizens in the Russian Federation”).
Serum CRP levels were evaluated with the use of the Randox Full Range CRP immunoturbidimetry assay (Randox Laboratories, Crumlin, Northern Ireland, UK), according to the manufacturer's recommendations.
Blood samples: 1 ml of blood was collected with a sterile syringe and mixed with 20 ml of a Brain-Heart Infusion broth (Conda Pronadisa, Spain). The mixture was incubated at 37°C for 7 days, streaked onto the surface of blood agar and MacConkey agar (Oxoid, UK) and incubated at 37°C for 24 h (23). Urine samples were collected in sterile containers. A loopful of the urine samples were streaked onto the surface of blood agar and MacConkey agar (Oxoid, UK) and incubated at 37°C for 24 h. All isolates were identified according to morphological and biochemical tests (Gram stain, capsule stain, motility test, indole production test, urease production test, Methyl Red test, Voges-Proskauer test) (24) and confirmed by matrix-assisted laser desorption-ionization time-of-flight mass spectrometry (Microflex, Bruker Daltonics, Bremen, Germany).
Antibiotic Susceptibility Testing
The antibiotic susceptibility of K. pneumoniae isolates was determined by the Kirby–Bauer disk diffusion method according to Clinical and Laboratory Standards Institute guidelines (CLSI) (25). Suspension of each K. pneumoniae isolate was spread by sterile glass rods on the surface of Mueller Hinton agar (Oxoid, UK). Then antibiotic discs (BioRad, France) were placed onto the surface of the inoculated Mueller Hinton agar plate. The plate was then incubated at 35°C for 18 h. Antimicrobial susceptibility was determined by measuring the diameter of the inhibition zone according to CLSI (25).
Test for Extended-Spectrum β-Lactamase Production
The K. pneumoniae isolates were evaluated for ESBLs by using a double-disk method according to CLSI (25). Amoxicillin/clavulanate discs were placed in the center of Mueller Hinton agar plate (Oxoid, UK). The disc of ceftazidime and cefotaxime were placed at the distance of 20 mm from the amoxicillin/clavulanic acid disc. The plates were incubated aerobically at 35°C for 18 h before the zone size recorded. A positive result was indicated when the inhibition zones around any of the cephalosporin discs were augmented in the direction of the disc containing clavulanic acid.
Single colonies, cultured on blood agar and MacConkey agar plates (Oxoid, UK), were obtained and studied for their ability to form viscous strings. The hypermucoviscousity was determined by the formation of viscous strings of >5 mm length (14). Isolation of K. pneumoniae strains and microbiological studies of obtained isolates were performed in the bacteriological laboratory of the Republican Clinical Infectious Diseases Hospital.
Bacterial colonies were grown on the surface of blood agar and MacConkey agar, collected and suspended in 50–100 μl of sterile distilled water. Total DNA was extracted from suspended cells with the use of an extraction kit (“Litech,” Russia) according to the manufacturer's recommendations.
Polymerase Chain Reaction (PCR) Detection of Virulence-Associated Genes
DNA samples were analyzed by using polymerase chain reaction (PCR). Primer sequences used to amplify fragments of the target genes are listed in Table 1. The reaction mix composition and PCR programs for amplification can be provided upon request. The amplicones were separated in 1.5% agarose gel and purified with the use of the GeneJET Gel Extraction Kit (Thermo Scientific, USA) according to the manufacturer's recommendations. The PCR-products were sequenced on a 3730 DNA Analyzer (Life technologies, USA) and compared with K. pneumoniae str. Kp52.145 plasmid II and chromosomal genome sequences from GenBank (Accession numbers FO834905.1 and FO834906.1, respectively) to confirm the target genes.
Out of 10 neonates with NS 5 were the term and 5 were preterm. Three preterm neonates were born earlier than 32 weeks of gestation, and another two ones—in the period from 32 to 36 weeks of gestation (Table 2). Two neonates were born with extremely low body weight (ELBW). Sepsis developed in five neonates on the first week of life, in three ones on the 2nd and 3rd weeks, respectively, and in two neonates on the 4th week. Sepsis was diagnosed in 5 neonates during their staying in a maternity ward, and in three ones (neonates with the ELBW)—in the NICU of the Children's Clinical Hospital. Two neonates fell ill at home.
NS clinically manifested in purulent meningitis (n = 3), enterocolitis (n = 3), and pneumonia plus enterocolitis (n = 2). In two cases the disease was associated with septicemia. Three mothers of neonates with sepsis had colpitis during pregnancy. The patients received a comprehensive treatment, including antibiotics, infusion therapy, mechanical ventilation, and intravenous immunoglobulins. Three cases of neonatal sepsis were fatal; two neonates had purulent meningitis and one necrotizing enterocolitis. Other seven neonates with sepsis successfully recovered.
Out of 10 neonates with UTI eight babies were born term and two—preterm. Both preterm neonates were born at 35 weeks of gestation. UTI developed in four neonates on the 3rd week of life, in six neonates on the 4th week. Only four out of ten infants had clinical manifestations, the main of which were fever and irritability. In the remaining six infants, UTI was asymptomatic. Two mothers of neonates with UTI had colpitis during pregnancy, in one case—pyelonephritis. All neonates received antibiotic therapy based on the findings of microbiological sensitivity tests.
In neonates with NS, all K. pneumoniae isolates were resistant to ampicillin, and six of them being resistant to all aminopenicillins (including protected ones), gentamycin and third-generation cephalosporins. At the same time, all K. pneumoniae isolates were sensitive to meropenem, amikacin, and ciprofloxacin (Table 3). Six isolates of K. pneumoniae produced ESBLs. In neonates with UTI, all K. pneumoniae isolates also were resistant to ampicillins. Six of them were resistant to gentamycin, four isolates—to protected aminopenicillins and third generation cephalosporins. All K. pneumoniae isolates were sensitive to meropenem, amikacin, and ciprofloxacin. Test for ESBL production was positive for 4 isolates of K. pneumoniae.
In the neonatal sepsis group, the rmpA gene (the main virulence factor of K. pneumoniae) was detected in 4 cases (40%). The presence of the rmpA gene in K. pneumoniae was associated with the development of purulent meningitis (3 cases) and enterocolitis (1 case). Only full-term infants had meningitis. Two of four children with the rmpA gene in K. pneumoniae isolates died. The “string test” was positive if the colony of K. pneumoniae showed the presence of the rmpA gene only. Aerobactin and colibactin genes were detected in two K. pneumoniae isolates. Both aerobactin-producing isolates were positive for iro D and iro N. One of two colibactin-producing isolates was positive for clb A and clb B, another was positive for clb B only. Aerobactin and colibactin genes were detected only in K. pneumoniae isolates, taken from the neonates with purulent meningitis who had an unfavorable outcome (Table 4). The production of aerobactin and colibactin directly correlated with the presence of the rmpA gene. The aerobactin and colibactin genes were not detected in two rmpA-positive K.pneumoniae isolates. In one case it was an infant with meningitis, who had a favorable outcome, in the other case—an infant with enterocolitis.
In neonates with UTI the rmpA gene, aerobactin, and colibactin genes were detected in 3 (30%) K. pneumoniae isolates. All aerobactin-producing isolates were positive for iro D and iro N. All colibactin-producing isolates were positive for clb A and clb B. The aerobactin and colibactin genes were not detected in rmpA-negaitive K. pneumoniae isolates.
The study of the impact of virulence factors of K. pneumoniae isolates on the clinical manifestations of neonatal infections revealed a high probability of the development of purulent meningitis (OR 9; CI 0.7–113) with an unfavorable outcome (OR 4.8; CI 0.3–65.7), but these differences were not statistically significant (Table 5).
Table 5. Comparison of clinical and laboratory data from neonates with and without virulent determinants.
Numerous studies have shown that antibiotic resistance and virulence of microorganisms are significant risk factors for NS (30, 31). Antibiotic resistance of bacteria is the main cause of non-effective therapy of nosocomial infections and sepsis. The antibiotic resistance of K. pneumoniae strains is associated mainly with the production of ESBL. In 2017 the World Health Organization included ESBL-producing K. pneumoniae in the list of the most dangerous superbugs along with Acinetobacter baumani and Pseudomonas aeruguinosa (32). Neonates are most vulnerable to infection. The predisposing factors to Gram-negative sepsis in newborns are associated with prematurity and low birth weight, as well as a prolonged stay in ICU (33, 34). In our study, in the neonatal sepsis group, five neonates were preterm, and two of them were born with extremely low body weight (ELBW). Six blood isolates of K. pneumoniae strains (60%) produced ESBLs. In neonates with UTI, K. pneumoniae isolates produced ESBL in 40% of cases. Contamination of neonates with ESBL producing K. pneumoniae strains could occur in a maternity ward, or during prolonged staying in ICU. Testing for antibiotic resistance showed that all ESBL producing K. pneumoniae isolates (from blood and urine) were resistant to all aminopicillins and third-generation cephalosporins. At the same time, all ESBL producing K. pneumoniae isolates were sensitive to meropenem, amikacin, and ciprofloxacin. Obviously, that meropenem should be considered as priority antibiotic therapy in cases of neonatal infections caused by ESBL-producing strains of K. pneumoniae. All blood and urine K. pneumoniae isolate, not producing ESBL, were sensitive to protected aminopenicillins, third-generation cephalosporins, meropenem, amikacin, and ciprofloxacin. Therefore, in cases of neonatal infections caused by ESBL-not producing strains of K. pneumoniae, protected aminopenicillins and cephalosporins III should be used as the first line of antibiotic therapy. The early onset of antibiotic therapy is known to play a crucial role in the efficacy of sepsis therapy since its delay increases the risk of death (35). However, clinical symptoms and laboratory signs of NS are not specific, and its early identification is a rather difficult task. The involvement of gastrointestinal tract may indirectly indicate the development of infection caused by Gram-negative bacteria, as the intestine is the main site of their colonization. Among laboratory signs of sepsis associated with gram-negative bacteria, a number of researchers designate common development of thrombocytopenia (36). In our study, all 10 neonates with sepsis had thrombocytopenia, which was severe (<50 × 109/L) in 8 ones. Five infants had enterocolitis. The most severe forms of sepsis in the infants studied, as well as its adverse outcomes, were associated with meningitis. It is worthy to note that neonatal meningitis occurred only in full-term infants, two of them were discharged home from maternity wards and fell ill on the second week of life. When analyzing this situation, we tend to associate the development of sepsis in neonates with their staying in maternity wards, because most K. pneumoniae isolates were ESBL-producers. This also can be supported by the fact that sepsis caused by K. pneumoniae occurred in six neonates who were in the same hospital during the same period. Unfortunately, neither medical staff of the maternity houses nor the mothers of these neonates were examined for K. pneumoniae carriage, so the above assumption cannot be confirmed. Despite the well-known role of ESBL-producing K. pneumoniae strains in the development of late onset of NS, it is also evident that the virulence factors of K. pneumoniae play an essential role in the development of the most severe forms of NS. The factors that are implicated in the virulence of K. pneumoniae strains include capsular polysaccharides, lipopolysaccharides, fimbrial adhesins, and siderophores (37, 38). The hypervirulent phenotype of K. pneumoniae is associated with the presence of the rmpA gene (14). Hv-KP causes the most severe, invasive forms of infection in previously healthy adults (liver abscesses, meningitis, and endophthalmitis) (12–14). Unlike cv-KP, hv-KP strains are more resistant to the complement and phagocytosis (38, 39). The mechanisms providing such stability are diverse and include protection against opsonization and phagocytosis by macrophages and neutrophils due to the presence of a thick capsule in K. pneumoniae and the blockade of TLR, in particular, TLR4, which inhibits the expression of interleukin-8 (38). Commonly, high virulence is typical for K. pneumoniae strains that cause community-acquired infections, and these microorganisms are usually sensitive to the majority of external antimicrobial factors. At the same time, recent studies demonstrate a new trend: hv-KP have acquired the main property of nosocomial microorganisms—antibacterial resistance. The impact of the hv-KP strain on the clinical features of neonatal infection is unknown. In our study, the rmpA gene was found in K. pneumoniae isolates in both groups of neonates, with NS and UTI. The detection of the rmpA gene in K. pneumoniae strains isolated from neonates with sepsis in three of four cases was associated with purulent meningitis. The detection of the rmpA gene in neonates with UTI was unexpected for us. Obviously, that other virulence factors, in particular, lipopolysaccharide (LPS) and siderophores, are necessary to ensure the virulence of K. pneumoniae. LPS protects against humoral defenses and activate immune system (20). Lipid A of LPS is a ligand for TLR4 (20). O-antigen of LPS protects against complement (20). Strains of K. pneumoniae that contain a full-length O-antigen (“smooth LPS”) are resistant to complement-mediating killing, while those with truncated or absent of O chains (“rough LPS”) are susceptible to complement-mediating killing, even in the presence of capsule (40). The lack of O-antigen K. pneumoniae less virulent. Detection of the rmpA gene in K. pneumoniae isolates in neonates with UTI indicates that the prevalence of virulent K. pneumoniae strains may be higher than we think. The prevalence of hv-KP in Russian Federation is unknown. The prevalence of hv-KP is very high in Asia (up to 90%) (41), in other regions of the world, it is less. In Spain and Canada, the prevalence of hv-KP was estimated at 5.4 and 8.2%, respectively (42, 43). In our study, two cases were caused by ESBL-producing K. pneumoniae isolates which were containing the rmpA gene. They were infants with meningitis, and both cases were fatal. In the group of infants with UTI, the rmpA gene was detected only in K. pneumoniae isolates not producing ESBL. Despite the small number of neonates included in this study, it is obvious that the acquisition of multidrug resistance by virulent strains of K. pneumoniae can worsen the course and prognosis of the disease. Siderophores—aerobactin, enterobactin, yersiniabactin, and colibactin are most important virulent factors that promote K. pneumoniae growth and survival in an infected host (7, 38). Enterobactin expression is ubiquitous among c-KP and hv-KP (44, 45). But aerobactin is expressed by 6% of c-KP and 93–100% of hv-KP isolates (44, 45). Siderophores are small, high-affinity iron chelating molecules secreted by a wide variety of microorganisms that are critical for virulence in many Gram-negative bacteria (7, 20). Iron is known to be essential for bacterial growth and replication (46). Access to iron molecules is an important factor that provides invasive properties of K. pneumoniae in an infection in immunocompetent people (46). Hv-KP strains produce siderophore molecules in a larger number and in their more active form than c-KP do (46). It has been shown that the development of invasive forms of the disease is associated with the production of several siderophores by K. pneumoniae strains (47). In our study, K. pneumoniae strains producing siderophores were detected in two neonates with sepsis and in three neonates with UTI. In all cases, aerobactin and colibactin genes were detected only in rmpA-positive K. pneumoniae isolates. However, fatal outcomes were noted only in cases caused by virulent strains of KP. In spite of the association between development of purulent meningitis and an unfavorable outcome in neonates infected mainly by virulent KP strains, we were not able to confirm this situation by statistical methods. Probably, this is due to a small number of newborns with purulent meningitis, which rarely occurs in this age group. We could not confirm the initial hypothesis that the development only the most severe forms of neonatal infection (purulent meningitis) is associated with virulent KP strains. UTI also can be caused by virulent strains of K. pneumoniae. Obviously, the role of virulent strains of K. pneumoniae will be increased in the future.
The prevalence of virulent strains of K. pneumoniae among neonates with sepsis and other neonatal infection is higher than we think. The risk of development of severe forms of neonatal infection can be associated with virulence factors. The most severe forms of neonatal sepsis with an unfavorable outcome in our study were due to virulent strains of K. pneumoniae.
KK, VA, and AR: design of the study, writing the manuscript. YD: DNA extraction of K. pneumoniae strains with subsequent genotyping by PCR method to determine virulence factors. DS: collection of clinical data. SL: collection and interpretation of clinical data. NS: isolation of K. pneumoniae colonies, determination of their antibiotic resistance and ability to produce of extended spectrum β-lactamase.
This study was supported by the Russian Government Program of Competitive Growth of Kazan Federal University. AR was supported by state assignment 20.5175.2017/6.7 of the Ministry of Education and Science of Russian Federation.
Conflict of Interest Statement
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
This study was supported by the Russian Government Program of Competitive Growth of Kazan Federal University. AR was supported by state assignment 20.5175.2017/6.7 of the Ministry of Education and Science of Russian Federation.
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2. Verma P, Berwal PK, Nagaraj N, Swami S, Jivaji P, Narayan S. Neonatal sepsis: epidemiology, clinical spectrum, recent antimicrobial agents and their antibiotic susceptibility pattern. Int J Contemp Pediatr. (2015) 2:176–80. doi: 10.18203/2349-3291.ijcp20150523
3. Stoll BJ, Hansen N, Fanaroff AA, Wright LL, Carlo WA, Ehrenkranz RA, et al. Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network. Pediatrics (2002) 110:285–91. doi: 10.1542/peds.110.2.285
4. Zaidi AK, Thaver D, Ali SA, Khan TA. Pathogens associated with sepsis in newborns and young infants in developing countries. Pediatr Infect Dis J. (2009) 28(Suppl. 1):S10–8. doi: 10.1097/INF.0b013e3181958769
5. Vergnano S, Menson E, Kennea N, Embleton N, Russell AB, Watts T, et al. Neonatal infections in England: the NeonIN surveillance network. Arch Dis Child Fetal Neonatal Ed. (2011) 96:F9–14. doi: 10.1136/adc.2009.178798
6. Zea-Vera A, Ochoa TJ. Challenges in the diagnosis and management of neonatal sepsis. J Trop Pediatr. (2015) 61:1–13. doi: 10.1093/tropej/fmu079
7. Shon AS, Bajwa RP, Russo TA. Hypervirulent (hypermucoviscous) Klebsiella pneumoniae: a new and dangerous breed. Virulence (2013) 4:107–18. doi: 10.4161/viru.22718
8. Podschun R, Ullmann U. Klebsiella spp. as nosocomial pathogens: epidemiology, taxonomy, typing methods, and pathogenicity factors. Clin Microbiol Rev. (1998) 4:589–603.
9. Haller S, Eller C, Hermes J, Kaase M, Steglich M, Radonic A, et al. What caused the outbreak of ESBL-producing Klebsiella pneumoniae in a neonatal intensive care unit, Germany 2009 to 2012? Reconstucting transmission with epidemiological analysis and whole-genome sequencing. BMJ (2015) 5:e007397. doi: 10.1136/bmjopen-2014-007397
10. Khaertynov KhS, Anohin VA, Nikolaeva IV, Semenova DR, Lyubin SA, Agapova IV. Neonatal sepsis caused by Klebsiella. Med News North Caucasus (2016) 11:82–6. doi: 10.14300/mnnc.2016.11004
11. Gelband H, Miller-Petrie M, Pant S, Gandra S, Levinson J, Barter D, et al. The State of the World's Antibiotics. Washington, DC: Center for Disease Dynamics, Economics, Policy (2015).
12. Liu YC, Cheng DL, Lin CL. Klebsiella pneumoniae liver abscess associated with septic endophthalmitis. Arch Intern Med. (1986) 146:1913–6.
13. Cheng DL, Liu YC, Yen MY, Liu CY, Wang RS. Septic metastatic lesions of the pyogenic liver abscess. Their association with Klebsiella pneumoniae bacteremia in diabetic patients. Arch Intern Med. (1991) 151:1557–9. doi: 10.1001/archinte.1991.00400080059010
14. Wang JH, Liu YC, Lee SS, Yen MY, Chen YS, Wang JH, et al. Primary liver abscess due to Klebsiella pneumoniae in Taiwan. Clin Infect Dis. (1998) 26:1434–8.
15. Decré D, Verdet C, Emirian A, Le Gourrierec T, Petit JC, Offenstadt G, et al. Emerging severe and fatal infections due to Klebsiella pneumoniae in two university hospitals in France. J Clin Microbiol. (2011) 49:3012–304. doi: 10.1128/JCM.00676-11
16. Bialek-Davenet S, Criscuolo A, Ailloud F, Passet V, Jones L, Delannoy-Vieillard AS, et al. Genomic definition of hypervirulent and multidrug-resistant Klebsiella pneumoniae clonal groups. Emerg Infect Dis. (2014) 20:1812–20. doi: 10.3201/eid2011.14020622
17. Yu WL, Ko WC, Cheng KC, Lee HC, Ke DS, Lee CC, et al. Association between rmpA and magA genes and clinical syndromes caused by Klebsiella pneumoniae in Taiwan. Clin Inect Dis. (2006) 42:1351–8. doi: 10.1086/503420
18. Zhang R, Lin D, Chan EW, Gu D, Chen GX, Chen S. Emergence of carbapenem-resistant serotype K1 hypervirulent Klebsiella pneumoniae strains in China. Antimicrob Agents Chemother. (2015) 60:709–11. doi: 10.1128/AAC.02173-15
19. Surgers L, Boyd A, Girard PM, Arlet G, Decré D. ESBL-producing strain of hypervirulent Klebsiella pneumoniae K2, France. Emerg Infect Dis. (2016) 22:1687–8. doi: 10.3201/eid2209.160681
20. Paczosa MK, Mecsas J. Klebsiella pneumoniae: going on the offense with a strong defense. Microbiol Mol Biol Rev. (2016) 80:629–61. doi: 10.1128/MMBR.00078-15
21. Zhang Y, Zhao C, Wang Q, Wang X, Chen H, Li H, et al. High prevalence of hypervirulent Klebsiella pneumoniae infection in china: geographic distribution, clinical characteristics, and antimicrobial resistance. Antimicrob Agents Chemother. (2016) 60:6115–20. doi: 10.1128/AAC.01127-16
22. Rossi P, Botgros R, Shane Tibby (UK), Nadel S, Manzoni P, Arenas-Lopez S. Report on the Expert Meeting on Neonatal and Paediatric Sepsis. London: European Medicines Agency (2010). Available online at: http://www.ema.europa.eu/docs/en_GB/document_library/Report/2010/12/WC500100199.pdf
23. Collee JG, Mackie TJ, McCartney JE. Practical Medical Microbiology. New York, NY: Churchill Livingstone (1996).
24. MacFaddin JF. Biochemical Tests for Identification of Medical Bacteria. 3rd Edn. Baltimore, MD: The Williams and Wilkins (2000).
25. Patel JB, Cockerill FR, Bradford PA, Eliopoulos GM, Hindler JA, Jenkins SG, et al. Performance Standards for Antimicrobial Susceptibility Testing. Wayne: Clinical and Laboratory Standards Institute (2015).
26. Luo Y, Wang Y, Ye L, Yang J. Molecular epidemiology and virulence factors of pyogenic liver abscess causing Klebsiella pneumoniae in China. Clin Microbiol Infect. (2014) 20:818–24. doi: 10.1111/1469-0691.12664
27. Compain F, Babosan A, Brisse S, Genel N, Audo J, Ailloud F, et al. Multiplex PCR for the detection of seven virulence factors and K1/K2 capsular serotypes of Klebsiella pneumoniae. J Clin Microbiol. (2014) 52:4377–80. doi: 10.1128/JCM.02316-14
28. Yu WL, Ko WC, Cheng KC, Lee CC, Lai CC, Chuang YC. Comparison of prevalence of virulence factors for Klebsiella pneumoniae liver abscesses between isolates with capsular K1/K2 and non-K1/K2 serotypes. Diagn Microbiol Infect Dis. (2008) 62:1–6. doi: 10.1016/j.diagmicrobio.2008.04.007
29. Lai YC, Lin AC, Chiang MK, Dai YH, Hsu CC, Lu MC, et al. Genotoxic Klebsiella pneumoniae in Taiwan. PLoS ONE. (2014) 9:e96292. doi: 10.1371/journal.pone.0096292
30. Centers for Disease Control and Prevention. Vital signs: carbapenem resistant Enterobacteriaceae. Morb Mortal Wkly Rep. (2013) 62:165–70.
31. Al-Hasan MN, Huskins WC, Lahr BD, Eckel-Passow JE, Baddour LM. Epidemiology and outcome of Gram-negative bloodstream infection in children: a population-based study. Epidemiol Infect. (2011) 139:791–6. doi: 10.1017/S0950268810001640
33. Samuelsson A, Isaksson B, Hanberger H, Olhager E. Late-onset neonatal sepsis, risk factors, and interventions: an analysis of recurrent outbreaks of Serratia marcescens, 2006-2011. J Hosp Infect. (2014) 86:57–63. doi: 10.1016/j.jhin.2013.09.017
34. Cortese F, Scicchitano P, Gesualdo M, Filaninno A, De Giorgi E, Schettini F, et al. Early and late infections in newborns: where do we stand? A review. Pediatr Neonatol. (2016) 57:265–73. doi: 10.1016/j.pedneo.2015.09.007
35. Rhodes A, Evans LE, Alhazzani W, Levy MM, Antonelli M, Ferrer R, et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016. Intens Care Med. (2017) 43:304–77. doi: 10.1007/s00134-017-4683-6
36. Arif SH, Ahmad I, Ali SM, Khan HM. Thrombocytopenia and bacterial sepsis in neonates. Indian J Hematol Blood Transfus. (2012) 28:147–51. doi: 10.1007/s12288-011-0118-7
37. Broberg CA, Palacios M, Miller VL. Klebsiella: a long way to go towards understanding this enigmatic jet-setter. F1000Prime Rep. (2014) 6:64: doi: 10.12703/P6–64
38. Li B, Zhao Y, Liu C, Zhou D. Molecular pathogenesis of Klebsiella pneumonia. Future Microbiol. (2014) 9:1071–81. doi: 10.2217/fmb.14.48
39. Doorduijn DJ, Rooijakkers SH, van Schaik W, Bardoel BW. Complement resistance mechanisms of Klebsiella pneumoniae. Immunobiology. (2016) 221:1102–9. doi: 10.1016/j.imbio.2016.06.014
40. Merino S, Camprubi S, Alberti S, Benedi VJ, Thomas JM. Mechanisms of Klebsiella pneumoniae resistance to complement-mediating killing. Infect Immunol. (1992) 60:2529–35.
41. Ye M, Tu J, Jiang J, Bi Y, You W, Zhang Y, et al. Clinical and genomic analysis of liver abscess-causing Klebsiella pneumoniae identifies new liver abscess-associated virulence genes. Front Cell Infect Microbiol. (2016) 6:165. doi: 10.3389/fcimb.2016.00165
42. Cubero M, Grau I, Tubau F, Pallarés R, Dominguez MA, Linares J, et al. Hypervirulent Klebsiella pneumoniae clones causing bacteraemia in adults in a teaching hospital in Barcelona, Spain (2007-2013). Clin Microbiol Infect. (2016) 22:154–60. doi: 10.1016/j.cmi.2015.09.025
43. Peirano G, Pitout JD, Laupland KB, Meatherall B, Gregson DB. Population-based surveillance for hypermucoviscosity Klebsiella pneumoniae causing community-acquired bacteremia in Calgary, Alberta. Can J Infect Dis Med Microbiol. (2013) 24:e61–4. doi: 10.1155/2013/828741
44. Podschun R, Sievers D, Fischer A, Ullmann U. Serotypes, hemagglutinins, siderophore synthesis, and serum resistance of Klebsiella isolates causing human urinary tract infections. J Infect Dis. (1993) 168:1415–21. doi: 10.1093/infdis/168.6.1415
45. El Fertas-Aissani R, Messai Y, Alouache S, Bakour R. Virulence profiles and antibiotic susceptibility patterns of Klebsiella pneumoniae strains isolated from different clinical specimens. Pathol Biol. (2013) 61:209–16. doi: 10.1016/j.patbio.2012.10.004
46. Holden VI, Breen P, Houle S, Dozois CM, Bachman MA. Klebsiella pneumoniae siderophores induce inflammation, bacterial dissemination, and HIF-1 stabilization during pneumonia. mBio (2016) 7:1397–16. doi: 10.1128/mBio.01397-16
47. Holt KE, Wertheim H, Zadoks RN, Baker S, Whitehouse CA, Dance D, et al. Genomic analysis of diversity, population structure, virulence, and antimicrobial resistance in Klebsiella pneumoniae, an urgent threat to public health. Proc Natl Acad Sci USA. (2015) E3574–81. doi: 10.1073/pnas.1501049112
Keywords: neonatal sepsis, Klebsiella pneumoniae, virulence, antibiotic resistance, extended-spectrum beta-lactamases
Citation: Khaertynov KS, Anokhin VA, Rizvanov AA, Davidyuk YN, Semyenova DR, Lubin SA and Skvortsova NN (2018) Virulence Factors and Antibiotic Resistance of Klebsiella pneumoniae Strains Isolated From Neonates With Sepsis. Front. Med. 5:225. doi: 10.3389/fmed.2018.00225
Received: 31 January 2018; Accepted: 24 July 2018;
Published: 14 August 2018.
Edited by:Olivier Vandenberg, Free University of Brussels, Belgium
Reviewed by:Pedro Xavier-Elsas, Universidade Federal do Rio de Janeiro, Brazil
Sergey Eremin, World Health Organization (Switzerland), Switzerland
Copyright © 2018 Khaertynov, Anokhin, Rizvanov, Davidyuk, Semyenova, Lubin and Skvortsova. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Khalit S. Khaertynov, email@example.com

domain: medical


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Netflix says “The Christmas Chronicles” is Kurt Russell’s biggest movie ever
Netflix doesn’t release viewership numbers, but claimed “The Christmas Chronicles” is the biggest movie of Kurt Russell’s career.
Netflix’s Chief Content Officer Ted Sarandos discuss the movie. Which debut last month, at the UBS Global Media and Communications Conference on Monday. It stars Russell as a “savvy, straight-talking” Santa Claus. Who teams up with young siblings to save Christmas after the pair crash his sleigh.
Sarandos said that, according to Russell, “The Christmas Chronicles” had the “most impact”. That of any of the actor’s movies after its release.
“It’s because, even in his successful career. He’s never had that many people see one of his movies in the first week ever,” Sarandos said. “That’s a testimony to what we can bring to the market for storytellers today. That we couldn’t have ten years ago.”
According to Sarandos, “The Christmas Chronicles” had 20 million views in its first week.
“If every one of those was a movie ticket purchase, that’s a $200 million opening week,” he said. “Even movies that go on to $1 billion don’t typically do that in the first week.”
But since Netflix doesn’t release concrete viewing data. We don’t know how many of those views are repeat viewings. Or how many people watch the entire movie.
For comparison’s sake, according to Box Office Mojo. Russell’s biggest theatrical release in the US before inflation is Marvel’s “Guardians of the Galaxy Vol. 2” last year. The movie score $146.5 million in its opening weekend and $183 million in its first week. It went on to gross almost $390 million domestically and $863 million globally. His biggest movie worldwide is “Furious 7” in 2015, which grosse over $1.5 billion total.
Director Clay Kaytis’ “The Christmas Chronicles” isn’t going to make audiences believe in the power of Christmas. Let alone stoke the spirit of the holiday season. But boy does it exhaust itself trying. The family-friendly adventure, about two kids whose Christmas Eve mission to capture Santa Claus (Kurt Russell). That leads to helping him save the holiday, plays like a love letter to producer Chris Columbus’ previous. That works without ever distinguishing itself. With its saccharine score, saturate cinematography, and trite platitudes. The film is formulaic and forgettable except for Russell’s performance as the lovable legend.
Christmastime used to be a season filled with warmth, laughter and love in the cozy Pierce home.
But since dad Doug (Oliver Hudson) died in a tragic firefighting accident, single mom Claire (Kimberly Williams-Paisley). She has been scrambling to restore some normalcy to her fracture family. One member who is absolutely excite for Santa’s return is precocious 10-year-old Kate (Darby Camp).
She gets hype for the holidays by reminiscing over home movies and recording her “Dear Santa” letter on the family’s old camcorder. Her older rebellious teen brother Teddy (Judah Lewis), on the other hand, is not nearly as thrill. Not only is he still grieving the loss of his father and hanging out with the wrong crowd. He’s also lost the belief that Santa exists.
The siblings’ world turns upside down once Kate unearths old video footage of an arm — possibly belonging to Saint Nick — tossing presents under their tree. She hatches a plan to get Santa on camera for online acclaim. In order to do this, she ropes Teddy into her scheme, blackmailing her brother with footage of him and his friends boosting a car. Instead of waiting for Santa to come to them, Kate and Teddy stow away on his high-tech sleigh.
Their ride-along of a lifetime quickly descends into calamity when they cause Santa to lose his concentration. His never-ending red velvet sack of presents, and the magic hat that allows him to spring from rooftop to rooftop.
With his sleigh damaged, those lost items strewn about Chicago, and a ticking clock on the night’s deliveries. Santa and the kids team up to save the world from losing their Christmas spirit. Only it’s the audience who loses their spirit as the hijinks unfold.
Kaytis and screenwriter Matt Lieberman rip a page from Columbus’ playbook by setting the majority of the film in Chicago. But also by rehashing similar scenarios from “Adventures in Babysitting” and “Home Alone.” There’s even a blues-theme musical number, “Santa Claus Is Back in Town,” sung by Russell with backup band Little Steven & the Disciples of Soul. Which is almost as lively as “Babysitter’s Blues,” courtesy of Russell’s magnetism, charisma, and innate likeability. The star makes the unfolding shenanigans tolerable, playing Santa as a kind of jovial emcee with sincerity, pathos, and gravitas.
The narrative follows a predictable path and fails to mine the “fish out of water” scenarios it sets up. That like the irony of stealing a car from a car thief, or the hilarity of the kidnapping that’s misunderstood by the police. This situational absurdity may have look good on paper, but isn’t execute with any zest or zing. Plus, we could also live without the groan-worthy and worn-out line about Santa’s fame “Ho, ho, ho” being “fake news.”
Genre: Animation, Comedy, Kids & Family
Directed By: Clay Kaytis
Stars: Kurt Russell, Darby Camp, Judah Lewis
On Disc/Streaming: Nov 22, 2018
CRITIC REVIEWS FOR THE CHRISTMAS CHRONICLES
The film’s no great shakes, but Russell’s star power in “The Christmas Chronicles” is a gift anyone should be happy to claim.
This festive family adventure for Netflix leaves you with a hyperglycaemic glow, and that’s mainly down to Kurt Russell as the most likeable Santa Claus in years.
The protagonists are not interesting characters, and the situations in which they are involved lack dramatic tension.
A modern take on a classic tale that serves as an enjoyable saturday morning flick. A lovely movie.


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If you or someone you know has a Medtronic implantable medicine pump, it is important to know about a recent Complaint Filed by the U.S. Attorney’s Office in regards to manufacturing problems. This injunction filed April 27, 2015 against Medtronic and its CEO, seeks to prevent them from selling SynchroMeds that have been adulterated and to force them to improve the quality of their manufacturing methods. It describes numerous violations of the quality system regulations at Medtronic Neuro and states that many of the violations related directly to the manufacture of the SynchroMed II implantable infusion pump. The complaint references four inspections where the FDA observed and documented violations.
If your SynchroMed pump is not functioning correctly or if you had your implant removed due to problems, please call or email our office to see if you can recover damages.
The Meyerson Law Firm, P.C. (512) 330-9001
The Meyerson Law Firm has filed suit against St. Jude Medical in regards to claims of manufacturing and warranty defects with its Eon Mini stimulator. Not to be confused with St. Jude Children’s Hospital, St. Jude Medical is a for profit company that sells various medical devices throughout the world. There have been recalls and numerous complaints regarding its Eon Mini stimulator, including that it causes burning sensations while charging, it delivers painful jolts, and its battery depletes too quickly. Removing the devices can be medically risky and permanent scar tissue can build up near the spine where the leads were implanted.
Last year a one year old in Austin, Texas accessed a coin shaped “button” battery from a Vizio stereo bar remote control and ingested it. The battery lodged in his esophagus and the electric current created a caustic agent that burned his throat tissue. This serious condition put him in the hospital for what is now months of operations, treatment and observation. The Meyerson Law Firm has filed suit in San Diego Federal Court alleging a dangerous design defect in the remote.
The Meyerson Law Firm urges everyone to look through their remotes and ensure that any which use button or coin shaped batteries are secured with child safe mechanisms. If you know of anyone whose child has been injured by a similar occurrence, please have them call The Meyerson Law Firm for a free consultation.
On February 28, 2012, our client Edith went in for surgery where the doctor used the NVM5 neuromonitor manufactured by Nuvasive, Inc. In the middle of the surgery, the orthopedic doctor aborted the procedure. Nuvasive admitted in emails to the doctor that their product did not work properly during the procedure and explained what they would do to prevent problems in the future. The patient incurred damage to her lumbar plexus which affected her ability to walk. Nuvasive now blames the doctor for the injury to the patient. The case is set for trial in the U.S. District Court, Western District of Texas in October of 2014.
FDA Alert – Specialty Compounding Products
Friday, August 9th the US Food and Drug Administration (FDA) sent out an alert informing health care professionals not to use any sterile products supplied by Specialty Compounding, Cedar Park, TX. Bacterial infections had been potentially associated with contaminated calcium gluconate infusions produced by the company. FDA had received reports of 15 adverse events experienced by patients in two hospitals; the patients had developed bacterial bloodstream infections caused by Rhodococcus equi, an organism commonly found in dry soil. Cultures from an intact sample of calcium gluconate compounded by Specialty Compounding show growth of bacteria that are consistent withRhodococcus species.
As of Monday, August 11th the FDA announced nationwide voluntary recall of all products for sterile use from Specialty Compounding. The recall applies to all unexpired sterile compounded products dispensed since May 9, 2013, including all strengths and dosage forms.
According to information provided by the firm, the recalled products were distributed directly to patients nationwide, with the exception of North Carolina. Recalled products were also distributed directly to hospitals and physicians’ offices in Texas.
Please call The Meyerson Law Firm today to discuss any case. 512-330-9001
I would like to express my sincere gratitude and thanks for everything your firm and especially Mr. Daniel Orocu have done in assisting with my case. Let it be known that Daniel has gone above and beyond to resolve an issue I thought would never end and exceeded my expectations with respect to the settlement received. These efforts are recognized and greatly appreciated and I felt the need to express that I have been totally impressed by the level of dedication, commitment and professionalism in dealing with Daniel and your staff.
Again, thank you for your time and assistance in this matter. I will highly recommend your firm and seek your assistance in any future legal matters.
Blas A. de la Garza
CEO, Southwestern Logistics Services LLC
St. Jude Medical has recalled certain models of Eon and Eon Mini implantable pulse generators (IPGs). IPGs are battery powered devices that are implanted into a patient’s spinal area and provide stimulation in order to reduce chronic pain.
IPGs require the implanted internal battery to be recharged. However, these devices suffer from significant problems. In certain models, the battery fails which then prevents the device from providing pain relief. In other cases, IPGs have severely burned patients while recharging the battery. Once a problem is detected, the devices must be surgically removed from the spinal area, subjecting the patient to a host of other risks and problems such as infection, pain and scarring.
St. Jude Medical (which is sometimes confused with St. Jude’s Children’s Hospital) has announced that the battery failure problems stem from weld failures within the internal batteries of the units, sometimes allowing fluid to spill out. The battery is fully contained in the titanium shell of the unit, however, and is not at risk of leaking into the body.
If you are having problems with your St. Jude Stimulator, please contact us to discuss how our firm can help you.
The Meyerson Law Firm, P.C. is currently investigating victims of a counterfeit version of the chemotherapy drug Avastin. A fly-by-the-night distributor going by the names Quality Specialty Products and Montana Health Care Solutions sold and distributed the counterfeit drug—which was nothing more than saline solution—to cancer patients across Texas. Our client subsequently died after his lung cancer returned following the administration of the counterfeit drug at South Texas Comprehensive Cancer Center in Corpus Christi. The drug company was not licensed as required by the Texas Department of State Health Services. Although the company has shut down and it appears its owners have fled to the Caribbean, there are potential claims against the facilities who purchased and administered the drug. Our firm has already retained experts to discuss how the Center breached its duties to its patients by purchasing and administering drugs from this unlicensed company. If you or a loved one is a victim of this counterfeit chemotherapy drug, call us for a free consultation.


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CEDAR RAPIDS — Thirty-seven seconds into their United States Hockey League game Saturday night, it was apparent the Cedar Rapids RoughRiders still have a Dubuque problem.
That was when Dubuque center Chayse Primeau scored his ninth goal of the season as the RoughRiders lost to the Fighting Saints for the 12th time in 14 games, 3-0, before 3,573 fans at the Cedar Rapids Ice Arena.
“Dubuque is a real strong club,” Cedar Rapids Coach Mark Carlson said. “We didn’t come out ready to play in the first period. I thought that was a major factor, so we’ve got some work to do.”
Only twice in the last 12 losses to Dubuque have the RoughRiders scored more than two goals, both this season. Cedar Rapids’ current ills stretch further than Dubuque. The RoughRiders (12-13-6) have lost five in a row overall, including a pair of overtime tilts.
Dubuque center Jan Kern posted his sixth goal of the season with 7:01 left in the second period.
The Fighting Saints’ defense not only notched their second shutout in two nights and third with three different goalkeepers this season, they bottled up red-hot Cedar Rapids center Marc McLaughlin. McLaughlin tallied two goals and three assists Friday against Team USA and has recorded six goals and eight assists in his last eight games before Saturday night.
“They play strong defense,” Carlson said. “It was more of a team effort on their part.”
Cedar Rapids was 0-for-4 in power-play opportunities.
Dubuque (16-11-4) added an empty-net goal from left wing Scott Corbett — his third this season — with 22 seconds left in the game.
ARTICLE CONTINUES BELOW ADVERTISEMENT
Right defenseman Josh Maniscalco distributed two assists, while left defensemen Jacob Semik and Brendan Bushy, plus right wing Quinn Preston were all credited with one for the Fighting Saints.
The RoughRiders visit Des Moines Sunday at 5:05 for the first of three road games before returning to the Cedar Rapids Ice Arena against Dubuque on Feb. 2.
“We take things day by day,” Carlson said. “So we’ll focus tomorrow on Des Moines and get ready to go.”
AT CEDAR RAPIDS ICE ARENA
Dubuque Fighting Saints 3, Cedar Rapids RoughRiders 0
Dubuque 1 1 1—3
Cedar Rapids 0 0 0—0
Scoring — Dubuque: Chayse Primeau (Quinn Preston, Brendan Bushy), 0:37.
Scoring — Dubuque: Jan Kern (Josh Maniscalco, Jacob Semik), 12:59.
Scoring — Dubuque: Scott Corbett (Josh Maniscalco), 19:38.
Shots on goal — Dubuque 36, Cedar Rapids 32.
Power-play opportunities — Dubuque 0 for 4, Cedar Rapids 0 for 4.
Goalkeepers — Dubuque: James Durham (32 saves); Cedar Rapids: Blake Pietila (33 saves).
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If you’re planning a trip to Morocco soon, chances are you’ve Googled something like “traveling to Morocco” or “travel tips Morocco” recently. And chances are you’ve come across articles about safety concerns in Morocco, detailing how to navigate this Muslim country as a non-Muslim or warning you about bargaining too much in this developing country.
Well we’re here to set the record straight. Below, we take a look at some of the most common myths about Morocco and give you the hard facts.
“Morocco, though it is visited by thousands of tourists every year, remains an unknown country – the greater part of it as uncharted to the European or American visitor as was Tibet a hundred years ago.” Gavin Maxwell, Lords of the Atlas, 2000.
The Ancient Granaries of Taliouine from Journey Beyond Travel on Vimeo.
Maxwell may have been writing almost two decades ago, early in the rise of google maps, satellite technology and the age of snap-happy travellers capturing selfies across the globe, but the quotation above still rings true. With so much of Morocco’s tourism being directed towards the Imperial cities and luxury riads of Fez and Marrakesh, many of the Maghreb’s treasures remain undiscovered by most or simply forgotten by all. (more…)
The people are what make the core of any culture. Today we’d like to introduce you to some of the faces of Morocco. The people behind these images are our friends and neighbors. The portraits come from all corners of Morocco and are a small sampling of who you might encounter when you come to visit. We hope you enjoy this glimpse of Morocco!
In the 1960’s and 70’s Morocco was part of the infamous “hippie trail.” Backpackers and travelers of all nationalities and types crisscrossed the cities, mountains, and coastal hideaways. More than a handful set out alone. Today, as people make travel an integral part of their life, Morocco has grown as a popular destination – certainly thanks to the tales of earlier travelers. If you are considering giving solo travel in Morocco a try, we’ve put together some tidbits and advice to help you plan and stay safe.
Halal tourism is a relatively new term and style of travel. It refers to meeting the needs and desires of Muslim tourists by providing services and amenities that Muslim travelers desire. There is no standard definition of defines an experience as falling into the category of halal travel, but several components stand out. In a 2014 poll by Crescentranking, one of the first companies to provide rankings of Muslim-friendly destinations, listed Morocco as the number six most “halal friendly” travel destination.
Thinking of traveling to Morocco but don’t know how to start planning everything? We’ve got you covered. From full-fledged travel guides to insightful documentaries, covering language books and helpful tips for you trip, we’ve compiled a list of the top 15 travel resources for your 2015 Moroccan adventure.


NOTICE OF VACANCY
Niles Community Schools is posting for the following
position to be employed (paid)
by the W-A-Y Alternative Education Program
May 29, 2013
W-A-Y Online Mentor
Required: Must hold a current Michigan Teacher
Pay Rate: $15.00 per hour (no benefits)
Applicants will need to commit to the equivalent of
7 hours of work per week,
spread over a 7-day period.
applicants must apply online at www.nilesschools.org. Applications will be accepted until interviews
employees will receive consideration without discrimination because of
religion, race, color, national origin, age, sex, height, weight, marital
status, or handicap. The Niles Community
Schools Board of Education complies with all federal and state laws and
regulations prohibiting discrimination.
Inquiries regarding compliance with Title VI of the Civil Rights Act of
1964 (race, color, or national origin) or Title IX of the Education Amendments
of 1972 (sex) may be directed to John Tanke, Director of Personnel,
269.683.6662; compliance with Section 504 of the Rehabilitation Act of 1973
(disability) may be directed to Diane Curry, Director of Special Education,
269.683.0757; all at the above address.
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Abbreviation for the set of rules "International Featured Standards" with a series of food, product and service standards. It was developed in 2003 by representatives of the European food retail trade as the "International Food Standard" and served as a uniform check of food safety and the quality level of producers. After several updates and the development of further standards, the brand was renamed to its current name.
After an expansion of the subject area, the name was changed. The IFS standards are intended to ensure that certified companies produce a compliant product or provide a service in accordance with the specifications agreed with the customers and work continuously on improvement through a continuous process. The standards and their requirements (checklists) are aimed at various participants in the supply chain.
For me, Lexicon from wein.plus is the most comprehensive and best source of information about wine currently available.Egon Mark
Diplom-Sommelier, Weinakademiker und Weinberater, Volders (Österreich)

domain: food


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"Today's Supreme Court decision marks a significant regression of our country," said NAACP General Counsel Janette McCarthy Wallace. "As a legal professional, I am horrified by this decision. As a Black woman, I am outraged to my core. The deciding Justices have ignored fundamental civil rights guaranteed by our Constitution and years of judicial precedent to advance a politically partisan agenda. There is no denying the fact that this is a direct attack on all women, and Black women stand to be disproportionately impacted by the court's egregious assault on basic human rights. We must all stand up to have our voices heard in order to protect our nation from the further degradation of civil rights protections we have worked so hard to secure."
"It is evidently clear at this time that the future of our democracy hangs in the balance. This Supreme Court is turning back the clock to a dangerous era where basic constitutional rights only exist for a select few. They've stripped away our right to vote, and now women have lost their right to their own body. What's next?" said Portia White, Vice President of Policy and Legislative Affairs. "We cannot allow our future to rest in the hands of those determined to crush every bit of it. We need to fight back. Just this week, the NAACP and Vote.org formed an alliance to register and mobilize voters in what will be the most critical midterm election America has ever faced. If you're not registered to vote, or know someone who isn't, now is the moment. This is no time for anyone to sit on the sidelines."

domain: sociology


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This morning, Trust Wallet announced that there is good news for users of the platform on Apple devices.
Hi Trust Wallet Family, We just wanted to give you a quick update on the Trust Wallet iOS App Store issue.
— Trust – Crypto Wallet (@TrustWallet) March 23, 2022
Several hours later, Trust Wallet made a statement announcing the return of its official app on the Apple Store.
And trust wallet posted a tweet on their official Twitter account, announcing the official return of their trust wallet IOS app on the Apple store.
Hi Trust Wallet family – great news! 🎉
Our iOS app is back on the App Store! Apple told us that some regions can take up to 72 hours to update the App Store.
Thank you for your patience! We will now go back to BUIDL mode to release great features and updates for you.
— Trust – Crypto Wallet (@TrustWallet) March 24, 2022
The announcement of the return of the application to the official store came after it was announced that it had been temporarily removed 48 hours ago, after the platform announced its attempts to find a solution to this problem in a short time.
The platform made it clear that the app will officially return to the store within the next 72 hours worldwide, as it has only returned in limited areas so far, and Apple is still working on bringing it back to all regions as it was before. .
The platform thanked all its users and Apple phone holders for their patience and promised to restore normal conditions as soon as possible and that it will add many new currencies to trade on its app.


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Bachelor of Film and Digital Media
Kobie has loved cinema since she was six years old; she remembers her sixth birthday present was a movie ticket from her older bother! She grew up watching films and animation, especially the cartoons on television every evening after school, and dreamt of one day producing and releasing her own independent film.
This childhood ambition was realised with Dark Dream, a two-minute surrealistic short film about ‘a person who wakes from a nightmare and finds themselves in a creepy, dark, surreal environment.’ The film’s visual effects were inspired by elements of Abstract Expressionism such as movement, line, and contrast. Kobie helped to compose the soundtrack, especially the ambient environmental sounds (the loud breathing, machinery, raining, door opening and closing, footsteps, murmuring voice, etc.). This involved modifying the timbre and pitch of the sound and music in post-production.
Kobie has also undertaken an internship with Roll Play Production of Monash Youth and Family Services, as well as an animation internship with Channel 31. She’s also been working as a Freelance Motion Graphic Designer in her spare time.
She will be completing her Bachelor of Film and Digital Media at Deakin in 2009. Deakin offered her a place after she finished the Advanced Diploma of Screen at Holmesglen Institute of TAFE. Kobie says she’s been able to ‘further enhance the skills and knowledge’ that she’d developed at Holmesglen. She adds that the teaching staff at Deakin ‘provided ample opportunity’ for her to realise her goals and ambitions. And with collaboration being such a vital aspect of film production, she’s also grateful that her course has allowed her to collaborate with other students on assignments and projects.


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Can you measure something that’s hot and cool in equal measure?
The much awaited 'Akula' is all set to make its debut at the MMRT, Chennai
Datsun currently has three cars in it's Indian portfolio
Royal Enfield is designing new engines and new bikes, and the UK Tech Centre is the hub of all this innovation. Here's...
This is the sixth edition of the winter series featuring Formula 3 spec cars
Go gear up like Valentino Rossi, for Tusker PAM has inaugurated Chennai’s first official D Store
The Swedish car maker opens its first dealership in Jaipur, the sixteenth in the country
A new Kwid in town
BMW begins assembly of the new X1 at their Chennai facility, priced at 29.9 lakh
TVS have launched an updated version of the the 110cc motorcycle, the Victor at Rs 49,490.


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domain: biology


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(via Urban Browser)
....another Hermes Sea Shell bicycle
(via reader submission and Brooke/love, brooklyn cruz)
The first photo is Hermes Bond Street, London and the second photo is Hermes Hamburg, Germany. A LOT of sea shells I'd say! I'm a pushover for beautifully embellished, art bicycles.


WASHINGTON ― Nearly two dozen Republican lawmakers are calling on President Joe Biden to engage with allies on emerging technologies like 5G networking and artificial intelligence in the face of China’s advancements.
House Armed Services Committee ranking member Mike Rogers, House Foreign Affairs Committee ranking member Mike McCaul, and House Science, Space and Technology Committee ranking member Frank Lucas signed a letter to Biden urging him to maximize alliances to counter “China’s vision for tech authoritarianism and protect our own economic and national security interests.”
Rep. Elise Stefanik, R-N.Y., led the Jan. 27 letter, signed by 23 House Republicans.
The message to Biden signals an avenue for bipartisan cooperation, just days after Secretary of State Antony Blinken appeared supportive of U.K. Prime Minister Boris Johnson’s efforts to forge a D-10 group of democracies ― South Korea, India and Australia, plus the G-7 nations ― to cooperate on 5G and vulnerable supply chains.
In his confirmation hearing last week, Blinken said: “Bringing concerned countries together, the digital democracies together in an appropriate forum, is the place to start.”
“I don’t want to minimize the challenge. We obviously have disagreements among democracies about a lot of profound questions about how technology is used, so we’ve got some work to do just to get our own collective house in order,” he said.
Western allies, under pressure from President Donald Trump, agreed to exclude Chinese tech giant Huawei from their 5G networks, claiming an espionage risk, something the company has denied. Since then, the European Union signed a long-promised investment deal with China last month despite the public concerns from the incoming Biden administration.
The Republican lawmakers, referencing Johnson in their letter, recommended raising the issue of China’s tech authoritarianism through the G-7 and NATO ― but also expanding engagements with allied democracies, and creating and hosting new international groups dedicated to democratic cooperation on technology.
They also called for the development of an allied network to encourage cooperation among companies in allied states to scale emerging technologies, and for the U.S. to help allies establish governmental bodies like the Committee on Foreign Investment in the United States to review foreign investments and prevent the transfer of allied technologies.
McCaul, who chaired the House’s Republican-only China Task Force, called on Biden to prioritize investments in domestic manufacturing of next-generation semiconductor chips in his expected infrastructure plan. McCaul has sponsored legislation to boost funding for basic research.
“We must work with our allies to ensure that our supply chain is secure and the future of technology is safely out of the hands of the [Chinese Communist Party],” McCaul said in a statement.
Democratic lawmakers have also raised alarms over China’s development of emerging technologies. After a report last month that Huawei tested AI software that could recognize Uighur minorities and alert police, Democratic Sen. Bob Menendez, the incoming Senate Foreign Relations Committee chairman, tweeted the following:
“A shocking reminder that #China continues to flout the ethical development of emerging technologies. The US must lead an effort with our allies to ensure the proper use of the digital domain predicated on the values of openness, stability, security, & protection of human rights.”
Joe Gould was the senior Pentagon reporter for Defense News, covering the intersection of national security policy, politics and the defense industry. He had previously served as Congress reporter.


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This is a replacement TSA Model Locking Collar, and is intended for use with the TSA Model Infusion 700N and 700E Pro helicopters. This package includes a set screw.
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Living with pain is never easy. Especially when the pain is in your back or in your neck, it seems to constantly affect the activities of your day to day life. Pain isn’t the only symptom that can put a damper on your life, but also, experiencing the correlating back and neck stiffness can make it even more difficult to live with. Typically, neck stiffness is accompanied by difficulty with turning of one’s head, soreness, headaches, and even shoulder or arm pain. If you are enduring neck stiffness, you may be wondering why, and what you can do about it… We’re going to talk about a few of the common reasons behind a stiff neck, and what you can do to alleviate the discomfort.
Sprain or injury
One of the most common reasons for a stiff neck is because of a tissue sprain or muscle strain. Usually, the levator scapulae muscle is most susceptible to these types of injuries. Various activities can be the culprit of this type of injury, including:
- Sleeping or sitting with your neck in an unnatural position for a long amount of time
- Sleeping with too many pillows, or too flat of a pillow
- Sudden or abrupt impact that forces the head to the side
- Turning the head to abruptly from side to side
- Sport’s injuries
Stress or anxiety
Excessive levels of stress or anxiety can also lead to stiffness in the neck. Unfortunately, lowering your stress and anxiety levels is easier said than done. You can try to manage your stress by researching and trying out a few various techniques. Try to consistently practice proper breathing exercises and stretching exercises to try and relax the muscles in your neck throughout the day. Depending on the severity of your pain and stiffness you may need to find a Plano physical therapist.
Poor posture or even looking down for a long amount of time, for example, on your smart phone or tablet can lead to neck stiffness as well. Try to avoid poor posture and prolonged awkward positions of the neck. If you are in a position where you are required to look at computer or tablet for too long, remember to practice relaxation exercises throughout the time you are doing so.
NeuroSpine Surgical Consultants has everything you need under one roof, from diagnosticians, surgeons, to recovery experts and rehabilitation therapists, we can assist you from start to finish. Contact us today, and we’ll help you get started on the journey back to better.


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Quesadillas are a quick but super satisfying meal option on a busy weeknight.
Advertisement - Continue Reading Below
- 1 lb. pork cutlets
- 1 tsp. ground ancho chili powder
- 1 red bell pepper
- 1 yellow bell pepper
- 8 flour tortillas
- 1½ c. shredded Monterey Pepper Jack cheese
- Store-bought guacamole (optional)
- Pico de gallo (optional)
- Sour cream (optional)
- Sprinkle pork cutlet strips with chili powder, 1/2 teaspoon salt, and 1/4 teaspoon pepper. Heat a nonstick skillet over medium-high heat. Add pork and brown all over, 3 minutes; remove from skillet. Add bell peppers and cook 3 minutes. Remove from skillet; toss with pork.
- Heat another skillet over medium heat. Place 1 tortilla in skillet. Spoon in 1/4 of the pork mixture, then top with 1/4 of the cheese. Place another tortilla on top, pressing them together.
- Cook quesadillas until browned on bottom, 3 to 4 minutes. Flip; cook second side 2 minutes. Remove from skillet; cut into wedges. Repeat with remaining ingredients. Serve with your favorite garnishes.
Starbucks Releases 3 New Valentine's Day Drinks You Can Only Get This Week
A whole lotta molten chocolate love.
Stop Everything And Try This Guacamole Onion Ring Recipe The Internet Is Freaking Over
A #worthit last-minute addition to your Super Bowl menu.


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New Venture Partners and Unilever Ventures Invest in Unilever Spinout Company, MiLife
1/15/2009 9:56:30 AM
LONDON--(BUSINESS WIRE)--New Venture Partners LLC, the global venture capital firm dedicated to corporate technology spinouts, and Unilever Ventures, the early stage venture arm of Unilever, today announced a joint investment in MiLife, a company focused on providing technology solutions for personalised weight management. MiLife will use the proceeds from the investment to assist with market expansion into the UK and entry into the US. In conjunction with the funding, Anton Arts of New Venture Partners joined the MiLife Board of Directors.
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domain: finance


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In Hearth's 2017 State of the American Dream Report, the research confirmed that "all generations - including millennials - agree home ownership is very important to achieving the American Dream.
When weighing the pros and cons of starting down the path to home ownership, there are several benefits to consider.
Equity. Every month that you pay your mortgage, a portion of that payment goes to the principal balance on the loan. You don't really notice it while its happening, but this builds the equity in your home. Home equity is the difference between the home's fair market value and the outstanding balance of all liens on the property. Put another way, the equity in your home is the portion that you truly "own."
Appreciation. This is the increase in the value of something over time. Home values have a well-documented history of going up over time. How much a home's value goes up depends on the local real estate market and any improvements made to the home. This increase becomes equity you can benefit from when you refinance or sell.
Tax Savings. The government rewards homeowners by providing excellent tax benefits. The interest paid on your mortgage and other home-related expenses can generally be deducted from your income.
Roots. People who own rather than rent stay in their home four times longer. This provides an opportunity to get to know your neighbors and connect with your local community.
Education. Research shows children of homeowners earn higher test scores and graduate at a higher percentage than those of renters.
Happiness. The feeling of owning your own home is unmatched. You can fix it up, redecorate, get a dog, or plant a garden if you want. The possibilities are exciting, right?
There are many benefits to home ownership, and despite some claims that home ownership's importance to the American Dream is in decline, Hearth's report found the dream of home ownership remains strong.
So strong, in fact, that in Hearth's report, Americans ranked "owning a home I love" higher than any other options, (including "starting a family" and "finding a fulfilling career") as an important part of the American Dream.


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And here’s the next page:
The full text reads: it’s not easy for anyone. it starts with putting one foot in front of another. go for it.
More coming next week.
I am creating art journaling pages each week for now. You can read more about this project here. This set uses the Fabriano Roma papers.