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By Annette Fuentes
New America Media
“Having been poor is no shame, but being ashamed of it, is.”
We’ve come a long way from Ben Franklin’s view of poverty as, if not a state of grace, then certainly no badge of dishonor. As the United States spirals toward a seeming second great depression, “the poor” are conspicuous by their virtual absence in the news media’s coverage or or politicians lip service to the increasingly hard times Americans face. Instead of “the poor,” we get “low-income” and “working families” and other more palatable terms for an economic state-of-being that most Americans would prefer not to acknowledge.
“As people do focus group testing, they don’t score well if they say they want to help poor people. It’s a word that most liberal and progressive groups shy away from. All their data show it’s not a popular term,” says Dean Baker, co-director of the Center for Economic and Policy Research in Washington, DC. “If you talk about helping working families and low-income people, that’s different. So if you talk about SCHIP [the State Child Health Insurance Program], you describe it as helping kids in families earning less than $20,000 a year. If you say, ‘We’re going to give a subsidy to poor families for health care,’ no one will support it.”
It wasn’t always so, notes U.C. Berkeley professor and labor expert Harley Shaiken. The 1960s featured a focus on the poor and poverty, with such landmarks as Michael Harrington’s 1962 book The Other America, which inspired the War on Poverty programs of Lyndon Johnson. The country’s poverty rate had reached an extraordinary 22 percent for individuals in the late 1950s, and the government made policies that slashed that rate almost in half by the mid-1970s. But there was a backlash against the poor and government programs to assist them that has reverberated for the last 40 years. “The poor became invisible. Politically not much has been done to address the core issues of people at the bottom,” Shaiken says.
Being poor is considered an individual failure in a successful society, he notes, but when failure becomes a collective experience, attitudes may begin to change. “This downturn is so severe that a huge chunk of the population now faces the credible prospect of becoming poorof losing a home, losing a job, not being able to afford college for your kids. The way I phrase, it’s not that it’s going to happen to everyone, but it credibly could. So many know a relative, a friend in this situation. Millions are facing being poor in an affluent society,” Shaiken says. “We can’t think of it as an individual failing when so many are in the situation. Now, the new reality is that to be poor is the consequence of poor policy.”
A corollary to the invisibility of the poor is the invisibility of the rich, a natural consequence of Americans aversion to acknowledge class distinctions. Especially as the gap between the super rich and the rest of us has grown into a Grand Canyon of income inequality over the last two decades. “We don’t talk about class. We don’t talk about the poor or the underclass. We don’t talk about the working class,” says Geoffrey Nunberg, professor of information science at UC Berkeley. “And we don’t have the ability to talk about the rich. We have this idea that we’re all middle class, so there’s a refusal to talk about a class that is so far from the rest of us. Even the rich don’t want to acknowledge that they’re rich.”
Who knows how deep the national and global economic downturn will go? For those at the top, the titans of Lehman Brothers and Citicorp, reduced circumstances mean something different than it does for the laid off auto worker. As more auto workers and Walmart clerks and Google technicians queue up at the unemployment line and at the food pantry doors, will disdain for “the poor” give way to class resentment at the hedge fund manipulators and government regulators who enabled their schemes?
“The recession was not sudden. We had it over a year. But the moment it burst onto wider consciousness, people began to wonder, ‘How are we going to make it? They don’t have time to be angry. But when this sinks in, there may be anger,” says Harley Shaiken. “If a ship is sinking and you’re in the water, you just worry about swimming. But then the anger comes when you think, ‘I wasn’t steering the ship.’”
Author Richard Rodriguez is less optimistic. “All the media coverage is on people losing ground, falling not on those who are already poor. When poverty was associated with racism as a reason for poverty, the idea of povertyor the poorwas acceptable. When it’s seen as a failure of the individual, our Protestant culture is not tolerant, even when the poor are children.”


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Posts with tag "Ludacris"
- Posted May 19th 2011 at 11:55 PM by Boombox Editors
Ludacris is not ready to tie the knot just yet, says a source close to the rapper. Amidst rumors that he and longtime girlfriend Eudoxie Agnan exchanged vows earlier this month, a source confirmed to XXL that the story was false. Stories of a possible marriage hit the media circuit after Agnan changed her Facebook status from "in a relationship" to "married," with no explanation. Celebrity...
- Posted Oct 6th 2009 at 10:53 AM by Denise Warner
Singer-songwriter and actor Jesse McCartney chatted about his new video 'Body Language,' which features T-Pain. McCartney tells PopEater that the video -- which features a lot of behind-the-scenes and tour footage -- "just accidentally happened." "It became this really fun intimate video," he adds. Jesse also talked about what it was like working with the hip-hop artist, who else he wants to...
Popeater Hot Topics
- Why Lady Gaga Looks for 'Clothes with a Soul'
- See Jimmy Fallon and Julia Roberts Peg Each Other in the Face with Balls (VIDEO)
- Review: The Goofy Genius of Guardians of the Galaxy
- Kelly Osbourne sued for allegedly trashing Los Angeles home
- Blake Shelton plays free concert in Atlantic City
- ?Big Bang Theory' cast will likely win wage dispute with CBS, insider says
- About that time Chris Pratt flashed Amy Poehler
- Entertainment Geekly: Or maybe ?Twilight' was the best thing to happen to Comic-Con
- ?Mindy Project' star Adam Pally reveals which celeb sex tape he owns
- Justin Bieber Moves Past Orlando Bloom Drama, Posts Flirty Selfie With Model Pal Shanina Shaik
- Don't Ever Change, Real Housewives of New Jersey! The Ladies Throw Down at a First-Responders Party—Watch Now
- Wait, What?! Cobie Smulders Was Almost Kate on Lost! Plus, Hear How HIMYM Made Her "F—king Weep"

domain: entertainment


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Descendant of the Crane
Author: Joan He
Genre: YA, Mystery, Historical Fantasy
Publisher: AW Teen
Release Date: 2019
Source: Netgalley/Publisher in exchange for an honest review
Synopsis: Tyrants cut out hearts. Rulers sacrifice their own. Princess Hesina of Yan has always been eager to shirk the responsibilities of the crown, but when her beloved father is murdered, she's thrust into power, suddenly the queen of an unstable kingdom. Determined to find her father's killer, Hesina does something desperate: she enlists the aid of a soothsayer―a treasonous act, punishable by death… because in Yan, magic was outlawed centuries ago.
Using the information illicitly provided by the sooth, and uncertain if she can trust even her family, Hesina turns to Akira―a brilliant investigator who's also a convicted criminal with secrets of his own. With the future of her kingdom at stake, can Hesina find justice for her father? Or will the cost be too high?
In this shimmering Chinese-inspired fantasy, debut author Joan He introduces a determined and vulnerable young heroine struggling to do right in a world brimming with deception.
My Review: Descendant of the Crane is a novel that is inspired by Chinese mythology and history. Hesina has always wanted to escape her duties as a princess. When her father is murdered, she becomes queen. Hesina has to manage her kingdom and find her father’s murderer through the help of Akira, a criminal. Can Hesina and Akira ever discover who the killer is?
As a huge fan of Chinese historical dramas, I was excited to read this book! I find that Descendant of the Crane did not disappoint! It had all the makings of a clever Chinese drama, political intrigue - betrayal, mystery, and deception! The heroine was strong and complex. Within the first few pages, I feel like I had come to know Hesina. She is a young girl that feels trapped inside the palace. She knows that somewhere within the palace is a murderer. I really admire Hesina’s quest for justice as she tries to solve the murder. Therefore, Hesina is a determined heroine that readers will love to root for.
Overall, this novel is about trust, justice, and responsibility. I liked all the characters. Akira was intelligent and mysterious. I also like her siblings, each of whom had different personalities. The world-building is lush and vivid in detail that is based on imperial China. The beginning started out slow but picked up pace halfway through the novel. I also did not like that it ended in a cliffhanger. Nevertheless, I’m excited to read the sequel! I recommend Descendant of the Crane for fans of A Forest of a Thousand Lanterns, Spin the Dawn, and The Magnolia Sword! This is not a novel to be missed!
Rating: 4 out of 5 stars

domain: literature


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Olive garden minestrone soup
Recipes / Olive garden minestrone soup (1000+)
Minestrone Soup, ingredients: 1 can minestrone soup, 1 can beef and noodle soup olive
Minestrone Soup, ingredients: 1 1/ virgin olive oil, 2 soup cans of beef broth, 2 soup
Minestrone Soup, ingredients: 1 pound hamburger meat, 1 lg. onion, cut up
Carrots (opt.), Parsley, basil, dill flakes, 1 can minestrone soup, Seasoned bread crumbs
Pasta Salad, Minestrone Soup, Ice Tea,, ingredients: 1 c. Cooked pasta, 1 c. Broccoli
of onion chopped 3 cans of Campbells Minestrone soup 1 can mild chili beans 1 can diced
to enjoy Olive Garden minestrone, so I, the resulting minestrone soup was pretty good
home to dinner ready and waiting!?! :) Minestrone Soup with Pesto Tortellini 1 onion 2
my favorite meals of all-time, my grandma's minestrone soup, and then changing it a bit to
Olive Garden” Minestrone Soup Who doesn’t love a bowl of hearty minestrone soup? It
Web Results with Olive garden minestrone soup
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Life: Ask your Neighbor: Olive Garden's Minestrone soup | recipe, minestrone soup, soup, soup with pasta
Groups / Olive garden minestrone soup (0)
make bread from scratch, soups, stews, cheap my freezer and herb gardens in my window
Gazpachos, Just about anytime is a good time for soup, whether it's served hot or cold
on its way and you all know what that means!! 'Soup's On' is a group I started for foodies
Baking with Olive Oil, Baking recipes that use Olive Oil in place of other oils/butter
Almonds and Goat Cheese, (2) Summer Vegetable Soup ith Mint Pesto, (3) Grilled Butterflied
Themes / Olive garden minestrone soup (0)
very best from scratch chicken noodle soup, main ingredient: Chicken, cook method: Boil
is a key component of good and long life, Use olive oil, it's healthier
Sopas (soups), Sopas. Simples assim. Adoramos sopas
Pressure Cooking, Pressure cooking is not just for soups! You can make all kinds of easy
microwave. They get soggy. Use a drop or two of olive oil in a hot skillet, and heat for a
Trusted Results with Olive garden minestrone soup
Saute onion, garlic and celery leaves in olive oil until onions are clear, 5 to 10 ... 1 HOUR MINESTRONE SOUP. brown the sausage meat in olive oil once the sausage is cooked, ...
Our most trusted Olive Garden Minestrone Soup recipes. Reviewed by millions of home cooks.
Our most trusted Minestrone Soup Olive Garden recipes. Reviewed by millions of home cooks.
1 HOUR MINESTRONE SOUP. brown the sausage meat in olive oil once the sausage is cooked, ... MINESTRONE SOUP WITH GROUND BEEF. In a 5 quart pan, cook beef, onion, ...
MINESTRONE SOUP. Slice sausage crosswise and ... and tomato sauce. ... MINESTRONE SOUP. Bring stock to boil, ... tender, stirring constantly. Add potato and ...
OLIVE GARDEN MINESTRONE SOUP. BAKING CHICKEN. CURRY CHICKEN BROCCLI. HAM BARLEY SOUP ... eggplant with 3 tablespoons olive oil, then sprinkle with ...
show results for food recipes drink recipes member recipes all ... Quick Minestrone Soup Gourmet, October 2006. search: go. Epicurious, for people who love to ...

domain: food


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Showing 1 - 20 of 28 results.
- Fairfax Video, June 2013 (4)
- A video of a car which is partially submerged in the Heathcote River. The river has burst its banks along Riverlaw Terrace.
- Caroline King, Daniel Tobin
- 9:59am 17th June 2013
- Riverlaw Terrace, Heathcote River, flooding, flood, car, Media, Communications and Journalism
- BeckerFraserPhotos February 2012 photograph 0951
- A photograph of flowers in a road cone. The photograph is captioned by BeckerFraserPhotos, "Ferry Road, Heathcote Bridge. Cones decorated for the February 22 anniversary".
- 11:39pm 22nd February 2012
- decorated road cones, Ferry Road, Heathcote River

domain: geography


This work in collaboration with Denis Chekhlov, Mark Pupilli and Andrew Calway, uses SIFT-like descriptors within a coherent top-down framework. The resulting system provides superior performance over previous methods in terms of robustness to erratic motion, camera shake, and the ability to recover from periods of measurement loss.
- Denis Chekhlov, Mark Pupilli, Walterio Mayol-Cuevas and Andrew Calway. Robust Real-Time Visual SLAM Using Scale Prediction and Exemplar Based Feature Description [PDF]. [VIDEO] In proceedings IEEE Computer Vision and Pattern Recognition CVPR, Minneapolis, Minnesota, USA. 2007.
- Denis Chekhlov, Mark Pupilli, Walterio Mayol-Cuevas and Andrew Calway. Real-Time and Robust Monocular SLAM Using Predictive Multi-resolution Descriptors [PDF]. To appear in LNCS proceedings of the 2nd International Symposium on Visual Computing, November 2006.


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Charne LouiseModel Female Gold Coast, Queensland, Australia
My Website: http://www.charnelouise.comMy MM URL: http://www.modelmayhem.com/charnelouise
Mayhem # 1464706
About MeLove being involved in creative ventures. I am currently situated on the Gold Coast, but am willing to travel for certain shoots. I have appeared in many newspaper editorials, magazines and so on. Currently I work as an cabaret performer and am involved in a very sort after cabaret burlesque troupe.
If you have any concepts or ideas please don't hesitate to contact me to discuss these as i am always looking to do something out of the ordinary, and love getting my hands dirty.
Music and the arts being are great loves of mine, I enjoy reading literature, swing dancing, old skool cars, watching documentaries and classic films, si-fi's, photography, 50's culture and roller derby .
Email me through here if you would like to work together.
Look forward to hearing from you soon.
Have you worked with Charne Louise? Add Credits for Charne Louise! >>
Credit NotesFemme Fatale magazine
Pinup America magazine 2 editions

domain: artistic


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We all wanted to experience how it is to ace a good win as we play on live online casino real money prices. But the question is, how?
We all know that making the turn to playing online poker from the usual can be a bit daunting and difficult. Even for those who are winners and high competitors in their local card game.
However, there are spoilt for choice still that’s why one should love playing on live casinos. There are different tools and techniques that will help you have an easy transition from live players to a newbie on playing online— eventually be masters and experts online. They even like the details too that are mentioned in the websites.
With that said, here are top online poker tips that you should take note off. Let’s check this blog post for more!
Online Poker Tips
An online poker game is not at all easy, but nobody said that it is no longer easy to learn. Here are a few tips that should guide as you made your way into becoming one of online poker’s experts.
With these tips, you should also be able to score a good win at live online casino real money jackpots and prices.
1 Begin with playing low stakes
You should know that starting with lower-stakes online is the best advice for beginners. The goal of these first sessions should be to familiarize yourself with the nuances of playing online. It should be your take to acknowledge the game and how you can better play along with it. Beginning with low stakes gives you more chance of being able to win at poker as you play for the long term.
2 Became familiar with the new aspects of online poker
You have to remember that this will be a lot more different than playing in an actual casino that is why you have to be familiar with the new aspects of online poker. Best to do your research prior to enrolling in an online game.
Also, easing into online poker instead of diving into the head-first will help you be acquainted with the novice with many of the unique aspects of online poker.
3 Start by playing with a single table
The best thing about online poker is that it allows you to play with multiple tables— but here’s the cue, you should always start by playing with a single table first. Don’t force everything quickly. Remember, a great understanding of the technical aspects of online poker will assist you in the coming weeks. Just learn your way to win online poker consistently with only one table then the rest should then go along smoothly.
4 create a distraction-free zone while playing
It is important that you should be free from distraction as you play online. Remember to off the television while playing, finish all your task prior to playing, keep the doors and windows shut to keep yourself free from outside’s distraction. Doing so will definitely take part in making sure your head is in the game as you play live online casino real money jackpots!

domain: hobby


text:
Being a pet owner isn’t always glamorous, and you’ll have to deal with things like pet cleanup and trips to the vet in return for your furry friend’s undying love and affection. Look at this video and find out how IBS is treated in cats.
In the cat world, IBS is really IBD, or inflammatory bowel disease. This disease can occur for several reasons, including food allergies and bacteria. The cause of the disease determines how treatment will go. Switching to hypoallergenic foods can help if the IBD is caused by a food allergy, antibiotics are used if the problem stems from bacteria, and antiparasitic medication may deal with parasites.
If you’re worried your cat has IBS or IBD, call EZ Petcare in Dallas at (888) 613-1320. Our animal experts specialize in pet food delivery and pet cleanup, so check out our website for details.

domain: medical


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This page contains Pump It Up: Exceed Unlockables for Xbox called "Unlock Survival Mode" and has been posted or updated on Oct 30, 2006 by sky44.
- Developer: Andamiro U.s.a. Corp.
- Publisher: Mastiff
- Genre: Rhythm / Music
- Release: Aug 29, 2005
- ESRB: Teen
Unlock Survival Mode
To unlock Survival Mode, play 20 different songs in Home Mode. Those 20 songs will then be available to play in Survival Mode. Playing more different songs in Home Mode will make them available for play in Survival Mode.
Please Submit a Problem for any incomplete, non-working or fake cheat listed above.
If you know other secrets, hints, glitches or level guides, then please Submit your Cheats and share your insights with other players.
Stuck in this game? Set a specific, clearly defined question and let other gamers answer your question or view answers to previously asked questions. If you think you are an expert then please try to help others with their questions.

domain: game


text:
Mental Health Awareness
Mental Health has been gaining attention recently. There are movies, art, books which are bringing out the gravity of this subject. Till some years back, it was a topic which wasn’t broached for it was considered futile. People suffering from mental health issues didn’t discuss it because they were afraid of those who wouldn’t understand it. It is a pathetic thing to note that we do not assign any value to our mental health which has a big role in our wholesome well-being.
Mental health relates to emotional, psychological and social well-being. It directly affects our way of thinking and acting upon it. This book, What Mina Did, discusses and explores the subject methodically. The protagonist Mina is haunted by her gruesome past resulting in hallucinations, severe anxiety, and nightmares. But then she has her husband who understands her condition and lends a supporting hand. He wraps her with unconditional love and comfort which accounts for the immense healing of a mental health patient. This is what they need to cure themselves – understanding and affection. We shouldn’t be condemning it and casting it aside as a taboo. We shouldn’t be calling out names to people who are grappling with it. We shouldn’t outright throw it in the lurches saying that it doesn’t matter much! It does. It does matter because once you grasp its enormity, you’d know how grave a challenge it is. It needs careful treatment and yes, it does need a treatment like all other diseases. It needs to be tended to for the scars really don’t disappear with time.
Don’t form illogical and baseless opinions on mental health. We need to prick the bubble of our stereotypes to help our loved ones. Being trapped in the clutches of depression is a valid point in the highly stressful times we are living in, social anxiety is a ‘real’ thing, and we being humans should help the ones facing challenges rather than giving their problems a cold shoulder. Be humane!
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domain: sociology


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This pristine 3 bed/2ba home is located in sought-after Morningside. Flooded with natural light, vaulted ceilings & juxtaposed elements of yesterday and today, this home offers comfort and charm with a touch of luxury throughout. Updated and modern design yet exuding classic charm. Unit features a fully updated kitchen with Viking stove and designer fixtures, separate living room, dining room and beautiful screened porch.
Enjoy the scent of flowers everyday Garden
Parking space is available for your convenience Parking Spot
Enjoy warmth and glow from wood or gas burning fireplace Fireplace
Stay comfortable during warmer season with installed air conditioning Air Conditioning
This duplex has a dishwasher Dishwasher
This duplex features hardwood floors Hardwood Floors
Property Also Includes
You can negotiate the price for this duplex on N Highland Ave NE, Atlanta.

domain: design


Pants with deco zipper / 5205-10
a very nice pant with a ligth baggy fit. The pants has chiffon at the front and a jersey at the back. At the front the pants has two deco zippers and two side pockets. The waistband has a wide elastic with chiffon. Style your pants with sneakers. Availible in color black and white.
Style no. 5205-10
Quality: 50% viscose, 50% polyester


text:
SIRT3 is attenuated in systemic sclerosis skin and lungs, and its pharmacologic activation mitigates organ fibrosis.
ABSTRACT: Constitutive fibroblast activation is responsible for organ fibrosis in fibrotic disorders including systemic sclerosis (SSc), but the underlying mechanisms are not fully understood, and effective therapies are lacking. We investigated the expression of the mitochondrial deacetylase sirtuin 3 (SIRT3) and its modulation by hexafluoro, a novel fluorinated synthetic honokiol analogue, in the context of fibrosis. We find that augmenting cellular SIRT3 by forced expression in normal lung and skin fibroblasts, or by hexafluoro treatment, blocked intracellular TGF-ß signaling and fibrotic responses, and mitigated the activated phenotype of SSc fibroblasts. Moreover, hexafluoro attenuated mitochondrial and cytosolic reactive oxygen species (ROS) accumulation in TGF-?-treated fibroblasts. Remarkably, we found that the expression of SIRT3 was significantly reduced in SSc skin biopsies and explanted fibroblasts, and was suppressed by TGF-? treatment in normal fibroblasts. Moreover, tissue levels of acetylated MnSOD, a sensitive marker of reduced SIRT3 activity, were dramatically enhanced in lesional skin and lung biopsies from SSc patients. Mice treated with hexafluoro showed substantial attenuation of bleomycin-induced fibrosis in the lung and skin. Our findings reveal a cell-autonomous function for SIRT3 in modulating fibrotic responses, and demonstrate the ability of a novel pharmacological SIRT3 agonist to attenuate fibrosis in vitro and in vivo. In light of the impaired expression and activity of SIRT3 associated with organ fibrosis in SSc, pharmacological approaches for augmenting SIRT3 might have therapeutic potential.
Project description:Systemic Sclerosis (SSc) is a rare fibrotic autoimmune disorder for which no curative treatments currently exist. Metabolic remodelling has recently been implicated in other autoimmune diseases; however, its potential role in SSc has received little attention. Here, we aimed to determine whether changes to glycolysis and glutaminolysis are important features of skin fibrosis. TGF-?1, the quintessential pro-fibrotic stimulus, was used to activate fibrotic pathways in NHDFs in vitro. Dermal fibroblasts derived from lesions of SSc patients were also used for in vitro experiments. Parameters of glycolytic function were assessed using by measuring extracellular acidification in response to glycolytic activators/inhibitors, whilst markers of fibrosis were measured by Western blotting following the use of the glycolysis inhibitors 2-dg and 3PO and the glutaminolysis inhibitor G968. Succinate was also measured after TGF-?1 stimulation. Itaconate was added to SSc fibroblasts and collagen examined. TGF-?1 up-regulates glycolysis in dermal fibroblasts, and inhibition of glycolysis attenuates its pro-fibrotic effects. Furthermore, inhibition of glutamine metabolism also reverses TGF-?1-induced fibrosis, whilst glutaminase expression is up-regulated in dermal fibroblasts derived from SSc patient skin lesions, suggesting that enhanced glutamine metabolism is another aspect of the pro-fibrotic metabolic phenotype in skin fibrosis. TGF-?1 was also able to enhance succinate production, with increased succinate shown to be associated with increased collagen expression. Incubation of SSc cells with itaconate, an important metabolite, reduced collagen expression. TGF-?1 activation of glycolysis is a key feature of the fibrotic phenotype induced by TGF-B1 in skin cells, whilst increased glutaminolysis is also evident in SSc fibroblasts.
Project description:The Insulin-like growth factor (IGF) system plays an important role in variety cellular biological functions; we previously reported levels of IGF binding proteins (IGFBP) -3 and -5 are increased in dermal and pulmonary fibrosis associated with the prototypic fibrosing disease systemic sclerosis (SSc), induce extracellular matrix (ECM) production, and promote fibrosis. We sought to examine the effects of another member of the family, IGFBP-4, on ECM production and fibrosis using cell-based, ex vivo organ culture and in vivo mouse lung fibrosis models. IGFBP-4 mRNA levels were significantly decreased in pulmonary fibroblasts of patients with SSc. ECM components were significantly reduced by endogenous and exogenous IGFBP-4. IGFBP-4 also blocked TGF?-induced ECM production, and inhibited ECM production ex vivo in human lung and skin in organ culture. In vivo, IGFBP-4 reduced bleomycin-induced collagen production and histologic evidence of fibrosis. Silencing IGFBP-4 expression to mimic levels observed in SSc lung fibroblasts resulted in increased ECM production. IGFBP-4 reduced mRNA and protein levels of the chemokine receptor CXCR4 and the pro-fibrotic factor CTGF. Further, CTGF silencing potentiated the anti-fibrotic effects of IGFBP-4. Reduced IGFBP-4 levels in SSc lung fibroblasts may contribute to the fibrotic phenotype via loss of IGFBP-4 anti-fibrotic activity.
Project description:Extracellular matrix deposition and tissue scarring characterize the process of fibrosis. Transforming growth factor beta (TGF?) and Insulin-like growth factor binding protein-3 (IGFBP-3) have been implicated in the pathogenesis of fibrosis in various tissues by inducing mesenchymal cell proliferation and extracellular matrix deposition. We identified Syndecan-2 (SDC2) as a gene induced by TGF? in an IGFBP-3-dependent manner. TGF? induction of SDC2 mRNA and protein required IGFBP-3. IGFBP-3 independently induced production of SDC2 in primary fibroblasts. Using an ex-vivo model of human skin in organ culture expressing IGFBP-3, we demonstrate that IGFBP-3 induces SDC2 ex vivo in human tissue. We also identified Mitogen-activated protein kinase-interacting kinase (Mknk2) as a gene induced by IGFBP-3. IGFBP-3 triggered Mknk2 phosphorylation resulting in its activation. Mknk2 independently induced SDC2 in human skin. Since IGFBP-3 is over-expressed in fibrotic tissues, we examined SDC2 levels in skin and lung tissues of patients with systemic sclerosis (SSc) and lung tissues of patients with idiopathic pulmonary fibrosis (IPF). SDC2 levels were increased in fibrotic dermal and lung tissues of patients with SSc and in lung tissues of patients with IPF. This is the first report describing elevated levels of SDC2 in fibrosis. Increased SDC2 expression is due, at least in part, to the activity of two pro-fibrotic factors, TGF? and IGFBP-3.
Project description:Objective:SSc is an autoimmune disease characterized by progressive fibrosis of the skin and internal organs. IL-6 and related cytokines that signal through STAT3 have been implicated in the pathogenesis of SSc and mouse models of fibrosis. The aim of this study was to investigate the efficacy of inhibiting STAT3 in the development of fibrosis in two mouse models of skin fibrosis. Methods:Biopsy samples of skin from SSc patients and healthy control subjects were used to determine the expression pattern of phosphotyrosyl (pY705)-STAT3. C188-9, a small molecule inhibitor of STAT3, was used to treat fibrosis in the bleomycin-induced fibrosis model and Tsk-1 mice. In vitro studies were performed to determine the extent to which STAT3 regulates the fibrotic phenotype of dermal fibroblasts. Results:Increased STAT3 and pY705-STAT3 was observed in SSc skin biopsies and in both mouse models of SSc. STAT3 inhibition with C188-9 resulted in attenuated skin fibrosis, myofibroblast accumulation, pro-fibrotic gene expression and collagen deposition in both mouse models of skin fibrosis. C188-9 decreased in vitro dermal fibroblast production of fibrotic genes induced by IL-6 trans-signalling and TGF-β. Finally, TGF-β induced phosphotyrosylation of STAT3 in a SMAD3-dependent manner. Conclusion:STAT3 inhibition decreases dermal fibrosis in two models of SSc. STAT3 regulates dermal fibroblasts function in vitro and can be activated by TGF-β. These data suggest that STAT3 is a potential therapeutic target for dermal fibrosis in diseases such as SSc.
Project description:Systemic sclerosis (SSc; scleroderma) is a multisystem fibrotic disease. The mammalian cleavage factor I 25-kD subunit (CFIm25; encoded by NUDT21) is a key regulator of alternative polyadenylation, and its depletion causes predominantly 3'UTR shortening through loss of stimulation of distal polyadenylation sites. A shortened 3'UTR will often lack microRNA target sites, resulting in increased mRNA translation due to evasion of microRNA-mediated repression. Herein, we report that CFlm25 is downregulated in SSc skin, primary dermal fibroblasts, and two murine models of dermal fibrosis. Knockdown of CFIm25 in normal skin fibroblasts is sufficient to promote the 3'UTR shortening of key TGF?-regulated fibrotic genes and enhance their protein expression. Moreover, several of these fibrotic transcripts show 3'UTR shortening in SSc skin. Finally, mice with CFIm25 deletion in fibroblasts show exaggerated skin fibrosis upon bleomycin treatment, and CFIm25 restoration attenuates bleomycin-induced skin fibrosis. Overall, our data link this novel RNA-processing mechanism to dermal fibrosis and SSc pathogenesis.
Project description:The mechanisms underlying persistent fibroblast activation and myofibroblast phenoconversion in underlying multi-organ fibrosis in systemic sclerosis (SSc) remain incompletely understood, hindering effective therapies to slow or reverse the process. Cyclin-dependent kinase 5 (CDK5) is a pleiotropic member of the CDK family originally identified in neuronal cells. In contrast to other CDKs, CDK5 activity depends on its CDK5R1 subunit p35. Here we demonstrate that expression of p35 and CDK5 activity are induced by TGF-ß in fibroblasts and adipocytic cell types. Levels of p35 are markedly elevated in both SSc skin biopsies and explanted SSc fibroblasts, as well as in fibrotic skin in mice. Ectopic p35 and CDK5 suppressed adipogenic markers while stimulating collagen production and myofibroblast markers, whereas RNAi-mediated CDK5 knockdown abrogated TGF-? fibrotic responses in a Smad-independent manner. Pharmacological inhibitors of CDK5 likewise prevented and reversed TGF-? responses in fibroblast monolayers and in ex vivo human skin organ cultures, ameliorated collagen overproduction in SSc fibroblasts, and prevented and reversed skin fibrosis in two distinct mouse models of SSc. Together, these results reveal a previously unrecognized key function for p35/CDK5 as a mediator of mesenchymal cell fibrotic responses. The results suggest a potential pathogenic role for elevated p35 expression and CDK5 activity in SSc, and raise the possibility that their selective pharmacological targeting might represent a novel treatment approach in fibrosis.
Project description:This data article contains complementary figures related to the research article entitled, "Transforming growth factor-?-induced CUX1 isoforms are associated with fibrosis in systemic sclerosis lung fibroblasts" (Ikeda et al. (2016) , http://dx.doi.org/10.1016/j.bbrep.2016.06.022), which presents that TGF-? increased CUX1 binding in the proximal promoter and enhancer of the COL1A2 and regulated COL1. Further, in the scleroderma (SSc) lung and diffuse alveolar damage lung sections, CUX1 localized within the ?- smooth muscle actin (?-SMA) positive cells (Fragiadaki et al., 2011) , "High doses of TGF-beta potently suppress type I collagen via the transcription factor CUX1" (Ikeda et al., 2016) . Here we show that CUX1 isoforms are localized within ?-smooth muscle actin-positive cells in SSc skin and idiopathic pulmonary fibrosis (IPF) lung tissue sections. In particular, at the granular and prickle cell layers in the SSc skin sections, CUX1 and ?-SMA are co-localized. In addition, at the fibrotic loci in the IPF lung tissue sections, CUX1 localized within the ?-smooth muscle actin (?-SMA) positive cells.
Project description:Type 2 insulin-like growth factor (IGF-II) levels are increased in fibrosing lung diseases such as idiopathic pulmonary fibrosis (IPF) and scleroderma/systemic sclerosis-associated pulmonary fibrosis (SSc). Our goal was to investigate the contribution of IGF receptors to IGF-II-mediated fibrosis in these diseases and identify other potential mechanisms key to the fibrotic process. Cognate receptor gene and protein expression were analyzed with qRT-PCR and immunoblot in primary fibroblasts derived from lung tissues of normal donors (NL) and patients with IPF or SSc. Compared to NL, steady-state receptor gene expression was decreased in SSc but not in IPF. IGF-II stimulation differentially decreased receptor mRNA and protein levels in NL, IPF, and SSc fibroblasts. Neutralizing antibody, siRNA, and receptor inhibition targeting endogenous IGF-II and its primary receptors, type 1 IGF receptor (IGF1R), IGF2R, and insulin receptor (IR) resulted in loss of the IGF-II response. IGF-II tipped the TIMP:MMP balance, promoting a fibrotic environment both intracellularly and extracellularly. Differentiation of fibroblasts into myofibroblasts by IGF-II was blocked with a TGF?1 receptor inhibitor. IGF-II also increased TGF?2 and TGF?3 expression, with subsequent activation of canonical SMAD2/3 signaling. Therefore, IGF-II promoted fibrosis through IGF1R, IR, and IGF1R/IR, differentiated fibroblasts into myofibroblasts, decreased protease production and extracellular matrix degradation, and stimulated expression of two TGF? isoforms, suggesting that IGF-II exerts pro-fibrotic effects via multiple mechanisms.
Project description:Objectives:SSc is a devastating disease that results in fibrosis of the skin and other organs. Fibroblasts are a key driver of the fibrotic process through deposition of extracellular matrix. The mechanisms by which fibroblasts are induced to become pro-fibrotic remain unclear. Thus, we examined the ability of SSc keratinocytes to promote fibroblast activation and the source of this effect. Methods:Keratinocytes were isolated from skin biopsies of 9 lcSSc, 10 dcSSc and 13 control patients. Conditioned media was saved from the cultures. Normal fresh primary fibroblasts were exposed to healthy control and SSc keratinocyte conditioned media in the presence or absence of neutralizing antibodies for TGF-?. Gene expression was assessed by microarrays and real-time PCR. Immunocytochemistry was performed for ?-smooth muscle actin (?-SMA), collagen type 1 (COL1A1) and CCL5 expression. Results:SSc keratinocyte conditioned media promoted fibroblast activation, characterized by increased ?-SMA and COL1A1 mRNA and protein expression. This effect was independent of TGF-?. Microarray analysis identified upregulation of nuclear factor ?B (NF-?B) and downregulation of peroxisome proliferator-activated receptor ? (PPAR-?) pathways in both SSc subtypes. Scleroderma keratinocytes exhibited increased expression of NF-?B-regulated cytokines and chemokines and lesional skin staining confirmed upregulation of CCL5 in basal keratinocytes. Conclusion:Scleroderma keratinocytes promote the activation of fibroblasts in a TGF-?-independent manner and demonstrate an imbalance in NF-?B1 and PPAR-? expression leading to increased cytokine and CCL5 production. Further study of keratinocyte mediators of fibrosis, including CCL5, may provide novel targets for skin fibrosis therapy.
Project description:Fibroblasts are the effector cells of fibrosis characteristic of systemic sclerosis (SSc, scleroderma) and other fibrosing conditions. The excess production of extracellular matrix (ECM) proteins is the hallmark of fibrosis in different organs, such as skin and lung. Experiments designed to assess the pro-fibrotic capacity of factors, their signaling pathways, and potential inhibitors of their effects that are conducted in fibroblasts have paved the way for planning clinical trials in SSc. As such, fibroblasts have proven to be valuable tools in the search for effective anti-fibrotic therapies for fibrosis. Herein we highlight the characteristics of fibroblasts, their role in the etiology of fibrosis, utility in experimental assays, and contribution to drug development and clinical trials in SSc.

domain: health


KIT INCLUDES THE FOLLOWING:
BWOODY SWAYBAR LINKS
BWOODY REAR ADJUSTABLE PANHARD BAR
BWOODY REAR ADJUSTABLE UPPER CONTROL ARMS
BWOODY REAR ADJUSTABLE LOWER CONTROL ARMS
Compatible with: 2006-2010 Jeep GC SRT8
SWAY BAR LINKS: factory sway bar links are a weak 5/16 in diameter and the way the factory mounts the passenger link bids the rear sway bar with a 1" offset. We corrected the offset by moving our passenger link inside the oem bracket, and ours are a whopping 7/8 in diameter and custom energy suspension bushings we used to improve handling even more. Our sway bar links are nearly triple the size of the oem links!! The weakest link of the srt-8's suspension is the sway bar links due to the lack of diameter and lack of strength, significant improvements in handling were felt on the test vehicle (mrfreeze). Adding these to your vehicle will make your srt-8 jeep handle like it should!! Note: Requires the use of a non-washable synthetic grease (such as a marine grade or a never seize lubrication on the faces of the bushings for increased life of the bushings) Order below in the drop down box if you wish to upgrade the links with grease fittings installed.
NOTE: (EROPEAN AND AUSTRALIAN CUSTOMERS ONLY) Some European Spec models may not have the required "triangle" Plates required to make the Rear Sway bar links fit (please verify before ordering). You may have to purchase the following part numbers (Left side: 05290769AC, Right side: 05290768AC) from the dealership to convert your Jeep SRT-8 to the U.S. spec to make these fit.
ADJUSTABLE PANHARD BAR: BWoody Performance Has designed the first Double adjustable polyurethane bushing Panhard bar for the SRT-8 Jeep and now their ready to release the next improvement to your Jeep SRT-8 suspension our Rear panhard bar it's constructed of 1.312" chromoly .125 wall tube (.100" larger than OEM) it's also round not square like the OEM bar, which everyone in the racing industry knows round is always stronger than square. Its also adjustable +3 / -3". To finish up we then included polyurethane bushings and grease fittings for long bushing life.
Also the OEM Panhard bar weighs in at 7.9lbs ours weighs 7.1 lbs. making it over 3/4 lb. lighter than stock!!!!
ADJUSTABLE UPPER & LOWER CONTROL ARMS: BWoody Performance 2006-2010 Jeep SRT-8 Upgraded Rear Fully Two way Adjustable Lower Control Arms, Manufactured from .133" wall a36 steel, Chromoly Threaded inserts, Chromoly Adjuster and upgraded delrin bushings these come in at 1.8 LBS lbs. lighter per side then OEM, so not only stronger but lighter too!!! Simply designed for one purpose in mind whether your tearing up laps at summit point or ripping up asphalt at your local drag strip too keep the rear tires planted. OEM lower control arms are weak rubber and we've been seeing many come in dry rotted and falling apart. Our test results have shown a consistent .07-.09 drop in 60 ft. times spraying a 100 shot of nitrous out of the hole. Grease fittings included.
Color shown is Gloss Red, standard color is Wrinkle black, you can upgrade to a different color by selecting from the drop down box below.
Note: Custom colors are non-returnable.
Want a smoother ride? Select BWoody bump stops in the drop down box below with this purchase and you'll receive our exclusive bump stops along with the necessary hardware to install them.
Disclaimer: Intended for off road use only.
*note: Due to the age of the vehicle, this package is special order and cannot be cancelled. Additional Lead time to be added for adjustable packages as noted below*
Note: Polyurethane bushings are no longer available for the control arms, Price increase includes Full Delrin upgrade.


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For Sale is this 20,000 book collection. This collection was accumulated over the years and is not old store stock. This collection is 90% individual copies, it is not 25 or 50 copies of some cover from a shop that ordered to many, there are some titles with multiples mostly Image and Valiant, but this is a Collection. It consists of Marvel, DC and Independents from 1960s to about 1994 , there are some newer books up to 1999, but only a few hundred. This collection is from Action to X-Men, and is perfect for a new store or Collector to add 20,000+ comics to keep, sell or trade.About 9000 are freshly bagged and boarded, the others mostly bagged. Tons of great books, no, Spidey 129 or Hulk 181 etc, but lots of fantastic books. Pictures are example of a few titles.
Also included are Comic cards Lexan sealed, un-opened comic card boxes, hard cover and soft cover graphic novels etc. Also included are the custom comic bins pictured. Condition ranges from G to NM with majority F+ to VF and thousands of copies NM. Drive or Fly down, rent a large U-Haul and drive home. The item "Comic Lot 20000 Book Collection Spider Man X Men Not Old Store Stock 1960s -94" is in sale since Sunday, January 20, 2019.This item is in the category "Collectibles\Comics\Bronze Age (1970-83)\Superhero\Mixed Items". The seller is "rebreathe" and is located in Bradenton, Florida. This item can't be shipped, the buyer must pick up the item.


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American Dairy, Inc. Announces Participation In The 22nd Annual Roth OC Growth Stock Conference
BEIJING and LOS ANGELES, March 15 /PRNewswire-FirstCall/ -- American Dairy, Inc. (NYSE: ADY; "American Dairy" or the "Company"), one of the leading producers and distributors of premium infant formula, milk powder and soybean, rice and walnut products in China, today announced its participation in the 22nd Annual Roth OC Growth Stock Conference, to be held March 15-17, 2010 at the Ritz Carlton in Dana Point, CA. Management is currently scheduled to present at 11:30 am local time on Tuesday, March 16, and to hold one-on-one meetings with investors following the presentation.
A webcast of the presentation will be available through the Company's IR website at www.americandairyinc.com. For additional information about the conference, please contact your Roth institutional sales representative.
About American Dairy, Inc.
American Dairy, Inc. (NYSE: ADY) is one of the leading producers and distributors of premium infant formula, milk powder, and soybean, rice and walnut products in the People's Republic of China. American Dairy conducts operations in China through its wholly owned subsidiary, Feihe Dairy, and other subsidiaries. Founded in 1962, Feihe Dairy is headquartered in Beijing, China, and has processing and distribution facilities in Kedong, Qiqihaer, Baiquan, Gannan, Longjiang, Shanxi, and Langfang. Using proprietary processing techniques, American Dairy makes products that are specially formulated for particular ages, dietary needs and health concerns. American Dairy has over 200 company-owned milk collection stations, two dairy farms, six production facilities with an aggregate milk powder production capacity of approximately 1,220 tons per day and an extensive distribution network that reaches over 90,000 retail outlets throughout China. For more information about American Dairy, please visit http://www.americandairyinc.com.SOURCE American Dairy, Inc.
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domain: economics


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Thursday, July 19, 2012
| 8:07:06 PM IST (+05:30 GMT)
4 Comments | 11752 Views | Copyright: IANS
Late superstar Rajesh Khanna's bungalow will reportedly be converted into a museum as per his daughters' wish.
"Yes, there are plans to convert Aashirwad into a museum, but nothing has been finalised yet. The family members will take the decision after Rajesh Khanna's 'chautha'. It's his daughters Twinkle and Rinke's wish to do so," a source close to Rajesh Khanna's family told IANS on condition of anonymity.
"It will be called Rajesh Khanna Museum and his precious things will be kept in the museum," added the source.
Rajesh Khanna died Wednesday after suffering liver infection. He was 69.
He is survived by his estranged wife Dimple Kapadia and two daughters.
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My upcoming Bollywood movie, Love Shagun has kept me on my toes!
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KLH Massivholz profitiert von Luftbefeuchtung
The Alpha high-pressure humidification system from Merlin provides top class air conditioning with added value for the well-known cross-laminated timber manufacturer.
Constant climate conditions
KLH Massivholz GmbH has been in existence for 20 years and is successful around the world. As a specialist in the production and cutting of cross-laminated timber elements, the trendsetter from Styria is well aware of the absolute necessity for humidification. "We need constant climatic conditions in our production facilities at all times of the year," explained Gernot Knapp, Technical Manager at the Katsch site, frankly. The Alpha high-pressure humidification system from Merlin Technology provides the first-class climate throughout the entire production premises. "The best price/performance ratio was the deciding factor," said the technical manager.
Healthy balance sheet
For KLH Massivholz, the investment in a modern humidification system with 11 zones has long paid for itself. "The reliable system is perfectly tailored to our needs and runs fully automatically," confirmed Knapp. KLH Massivholz is already looking to the future. The company location in Katsch will continue to grow. "Every expansion is accompanied by an expansion of the tried-and-tested humidification system," said Knapp, attaching great importance to continuity. Ultra-fine atomisation and uniform distribution is the heart of the Alpha system from Merlin Technology. The zones can be individually humidified if required.


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Ron Pagano, a flight-test engineer for 34 years with the Hamilton Standard Division of the United Aircraft Corporation (now United Technologies Corporation) shares his lifelong love of aviation in his debut book, The Adventures of an Airplane Nut.
While many books on aviation tell the stories of flight heroes and aces, Ron tells his story as an average guy who caught a chronic case of flight fever.
Ron had the opportunity to fly in more than 100 different types of airplanes over the course of his career.
The experiences that Ron describes in The Adventures of an Airplane Nut range from flying in Piper Cubs and World War II airplanes to viewing the largest flying boat ever built, involvement in the flight of a car/plane hybrid, and witnessing the aftermath of a bizarre airplane murder/suicide.
Both during and after his tenure as a flight-test engineer testing aircraft components built by Hamilton Standard, Pagano was an active member in the Experimental Aircraft Association and Warbirds of America, as well as the Airdale Flight-Line Operations crew at several air shows.


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The firm’s clientele also includes commercial real estate developers and construction contractors in planned unit developments, subdivisions, and condominium conversions.
William C. Brewer & Associates drafts or reviews agreements, contracts, and leases in precautionary anticipation of conflicts and with a focus on protective client solutions. Should disputes arise from a business transaction, the firm has a sound reputation as effective commercial litigation and contracts attorneys.
William Brewer has owned and operated several companies, including a 75-employee food-processing and distribution firm. With his business owner experience, in addition to practicing law for more than 35 years, he can impart insightful legal advice that protects clients and their investments. As a business owner, he understands what it takes to meet payroll and deal with the major regulations and day-to-day issues that confront a business daily.
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Contact William C. Brewer & Associates today at (304) 291-5800 to speak directly with an attorney, or email the law firm to make an appointment. William C. Brewer & Associates, PLLC strives for cost-effective and responsive representation, and the firm offers client-friendly options for the payment of legal services.

domain: law


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If you’ve done some research into the Chaga mushroom, you will have no doubt heard of the term ‘adaptogenic’: it’s been a bit of a buzz word for a while now, but in case you are still unsure, we thought we’d put it in a nutshell.
Adaptogens are harmless, natural substances which help our bodies deal with stress through their rebalancing and restorative effects. They support and adapt to the body by responding to many influences and stressors, and help set your body back into its normal rhythm.
Adaptogens specifically target the adrenal glands, recharging them as needed. Adrenal glands, AKA the suprarenal glands, are small glands sitting on top of both kidneys. They are highly important as they secrete more than fifty hormones that help regulate your metabolism, blood pressure, response to stress and other essential functions.
Chaga may take its adaptogenic properties from the high levels of manganese it contains. Manganese helps make and activate some of the enzymes that help the body carry out chemical reactions.
As a bonus, adaptogens also modulate the immune system.
So, if you needed another great reason to have that daily cup of Ötzibrew Chaga, here it is.


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Satellite-derived 2003 wildfires in southern Siberia and their potential influence on carbon sequestration
Huang, S., Siegert, F., Goldammer, J.G. and Sukhinin, A.I.
International Journal of Remote Sensing, Vol. 30 Issue 6 pp. 1479-1492
The burned area, fuel type, crown fire percentage, and carbon release of the southern Siberia 2003 wildfire were analysed using AVHRR, MODIS, MERIS, ASTER images and a carbon release model. More than 200 000 km2 were burned from 14 March to 8 August 2003, of which 71.4% was forest, 9.5% humid grassland, and 2.15% bogs or marshes. During 1996 to 2003, 32.2% of the forested area and 23.36% of the total area was burned, and 13.9% of the total area was affected by fire at least twice. Direct carbon emission from this 2003 fire was around 400640 Tg. The 2003 Siberian fires could well have contributed to the high increase of the atmospheric CO2 and CO concentration in 2003. The increasing human pressure coupled with intensive fire severity, recurrent fire frequency, and increasing occurrence of summer droughts will reduce the carbon sequestration potential of this important carbon pool.


[It] would’ve been nice if a studio that’s known for creative and original storytelling had decided to do something more interesting with their first female protagonist (in SIXTEEN YEARS) than make her…a princess. Who’s cool because she’s good at “boy” stuff. How fresh and exciting! Ugh. Granted, Tangled was one of my favorite movies from last year, but it was also an adaptation of a classic fairytale. Pixar had the opportunity to do anything with this, and they’re just rehashing the same old, same old.
Sadly, “girl struggles against restrictive society” is still a very relevant theme, but it would be awfully nice to see a story about a regular person who has adventures and, oh yeah, also happens to be female. And who maybe likes to read or do needlepoint instead of or in addition to kicking ass, because there is nothing wrong with those kinds of things. I’ve always found the tomboy ideal so prevalent in fantasy fiction and film particularly irritating, sometimes more so than the passive damsel ideal, because it’s still presenting traditionally masculine pursuits as superior.
I had the same reaction as Couchman. I love most of the Pixar movies (well, all of the Pixar movies that don’t feature anthropomorphic vehicles) and found myself shrugging at this trailer, hoping it doesn’t represent the actual movie. While the Highland setting looks compelling, the heroine’s setup feels disappointingly stock.
Sure, gender roles can be restrictive — but so can these rebellious-princess tropes. “A lady pursues elegant pursuits,” her mother chastens. “Show a little decorum!” her father grouses. We don’t see her getting squeezed into a corset, but we get all of the other requisite beats: bored by ceremony, shooting a bow, escaping on horseback.
Studios grumble that boys won’t go to see movies featuring female protagonists, and I think this is why: the trailer shows a frustrated daughter rather than an adventurer.
Link via Faruk Ateş.


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Experiment with totally different foods and timings during your training and see what works best in your physique. OUR IMAGINATIVE AND PRESCIENT: A day when all folks impacted by disabilities dwell nicely. Eating a diet wealthy in health foods is essential to our well being. Consuming the correct amount of meals may also assist you handle your blood glucose level and your weight.
Because in terms of reaching a healthy weight, what you do not eat is way, rather more necessary. You’ll be able to trigger a coronary heart fee reading on demand by opening the Heart Charge app on the watch, but the Apple Watch is also taking measurements all through the day to get your common resting and strolling heart charges. An effective calorie counter, it could actually take you lower than 5 minutes a day to track your diet and exercise, that means it’s a fast behavior to get into.
Supreme snacks comprise lean protein, wholesome fats, and sophisticated carbohydrates—for example, yogurt with granola, an apple with low-fat cheese, or peanut butter on crackers with a banana. Between lengthy nights finding out (or partying), consuming junk food and being in shut quarters with people, staying healthy can be a problem in school. Fasting is usually a safe technique to shed pounds as many studies have proven that intermittent fasting – fasting that is controlled within a set variety of hours – allows the physique to burn fat cells extra effectively than simply regular dieting.
Try to eat five parts of fruit and greens a day. Water Exercise classes match a variety of age teams and skill units. MENTOR Grownup Day Well being helps elders and other adults from a variety of cultures dwell full, more active lives in the neighborhood. Individuals can get vitamin D from the sun and a few foods. I hope you may take advantage of this Ramadan firstly to enhance yourselves spiritually, after which to kick-begin your fitness journey and get in form by way of the numerous well being and weight loss benefits of fasting.


text: BALLSTON SPA — Following a water main break, village residents are advised to boil water under further notice. Village DPW crews worked from 11:30 p.m. Saturday until dawn Sunday morning repairing the break, which occurred in one of the older sections of the water line from Old Ballston Avenue across Route 50 to Saratoga Avenue. The transmission pipe was installed around 1950, according to village Mayor John Romano. The ruptured line was not weather-related, Romano said. “The crews worked all night repairing the pipe, and although water service was shut down for residents in that general area, since it was overnight, it didn’t affect many water users,” Romano said. Restarting the system stirred up sediment, mostly sand and soil, and the water is not contaminated by sewage. The boil-water recommendation is an advisory rather than a mandate. Water should be boiled both for drinking and cooking purposes, as well as for use in automatic dishwashers and washing machines. DPW crews typically begin hydrant flushing to rid the system of sediment in late April, but the twice-annual process was started last night, and is expected to be completed by week’s end. Romano said he anticipates water samples to be cleared by the health department for public consumption later today. “We expect the report to come back with no contamination Tuesday,” Romano said.

domain: news


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A large variety of top-quality foods, beverages, and sweets prepared by renowned chefs will be offered during the month. The extensive and rich daily buffet will include Saudi, Lebanese, Indian, and Italian food stations, in addition to an international buffet that satisfies every taste. Mövenpick's premium ice cream, live crepe station, and an extensive variation of Arabic sweets will also be available to satisfy guests' sweet tooth.
Bait Al Qamar: Iftar SAR 295 17:30 – 20:30 …Kids from 6-12 50% off
Horizon: Iftar SAR 225 17:30 – 20:30… Kids from 6-12 50% off
Horizon Suhoor: SAR 215 23:00 – 03:00…. Kids from 6-12 50% off
|Iftar||Serving from 5:30 to 8:30 pm|
|Iftar Price||SAR 295 per person. Kids from 6-12 50% off.|


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Thousands of co-operative retail stores across the country will be celebrating this year’s Co-operatives Fortnight.
Through retail co-operatives that are members of the Co-operative Retail Trading Group, which has a reach of over 5,000 food stores, the Co-operatives Fortnight theme of local, loved and trusted will be highlighted.
Over 20 shelf-talkers, pictured above, will be on display with popular products produced under The Co-operative brand in stores. Shoppers will read why its products are loved by highlighting some big award wins; they will also see why products should be trusted, which will highlight welfare or ethical standards; and visitors in stores will also view messages about how initiatives have improved local communities.
As well as a focus on running in-store promotions to help customers choose co-operative, retail societies will be running events for members and the general public and helping raise awareness of Co-operatives Fortnight among colleagues.
The Co-operative Group will be hosting a family fun day following the Fortnight on July 7th at Chester Racecourse. The community event will host cooking demonstrations, a sports zone, music performances and attractions for children. (See more online: www.co-operativememberevents.coop)
Midcounties is hosting a community fun day in Warwick on June 23rd, which will feature actor Alan Halsall, known as Coronation Street’s Tyrone Dobbs. To mark the start of the Fortnight, St Nicholas Park will host the event with games, entertainment and circus acts. (See midcounties.coop for more details)
Hundreds of Midlands Co-operative members will be joining Fortnight celebrations at Co-operative Congress in Cardiff. Nine coach points across the region will take people to learn more about co-operatives and enjoy family-friendly activities at the SWALEC Stadium.
Chelmsford Star Co-operative will be hosting a shopping evening, which will introduce customers and members to local Essex products available in the society’s stores. Tastings from beer and wine to ice cream and bacon will take place on July 4th from 6pm at the Quadrant department store on Moulsham Street.
In the run-up to the Fortnight, Lincolnshire Co-operative has been engaging staff so they can help spread the word to members and customers. Chief Executive Ursula Lidbetter says: “We’ve already been out and about to different locations with our co-op hearts, and we’ll be calling at more over the next few weeks including our local producers, schools we work with and other co-ops in the area.”
In this article
- Brand management
- Chelmsford Star Co-operative Society
- Co-operative Retail Trading Group
- Co-operatives Fortnight 2013
- Consumer cooperative
- Contact Details
- Lincolnshire Co-operative
- Midcounties Co-operative
- Midlands Co-operative Society
- Person Career
- Retail Trading Group
- Social Issues
- The Co-operative brand
- The Co-operative Food
- The Co-operative Group
- United Kingdom
Join the Conversation


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Two weeks ago, Florida Governor Ron DeSantis made the controversial decision to re-open the Sunshine State’s beaches, despite the ongoing coronavirus pandemic. Fed up with being forced to remain indoors for over a month, Floridians cast social distancing aside and made a mad dash for their nearest beach.
Beachcombers took a special interest in discovering what kinds of debris may have washed up on the beach over the past month of isolation, but one Floridian found much more than they bargained for. Last Thursday, an anonymous beachgoer discovered a mysterious blue plastic barrel stuffed with cannabis flower floating just off shore in Marathon, a city in the Florida Keys.
Rather than taking advantage of this sudden windfall to celebrate a belated 4/20 on the beach, the upright citizen notified the Monroe County Sheriff’s Office. When arriving on the scene, cops discovered that the barrel contained five separate bales of weed, also known as square groupers, which contained around 90 pounds of dried bud. The police then notified US Border Patrol agents, who seized the contraband.
Discovering the massive stash of weed was quite a surprise for the anonymous tipster, but Florida cops are used to seeing pot and other drugs wash up onshore. Florida is often the first point of entry for drug smugglers coming from South America, and some smugglers end up being forced to dump their contraband in an attempt to evade American law enforcement.
Although police do not know exactly where this weed was supposed to be shipped to, some of it may have been destined for the local black market. Florida currently has a robust medical marijuana program, despite the interference of conservative lawmakers, but recreational use remains illegal. Activists have been working to place an adult-use legalization measure on this year’s general election ballot, but politicians managed to interrupt this process with a new law that makes it nearly impossible for ballot initiatives to succeed.
Hurricane season is the most common time for Florida cops to discover mysterious drug bundles washing up on family-friendly beaches. Last September, in the wake of Hurricane Dorian, beachgoers discovered over a dozen bricks of pure cocaine randomly washing up all along Florida’s Atlantic coast. And one year before that, cops seized over a hundred pounds of black market weed washed up on the beach after Hurricane Florence ravaged the state.
The Sunshine State is not the only coastal state where illicit drugs wash up on shore, though. Last year, sunbathers at a San Diego beach found an abandoned motor boat packed full of weed, and the Southern California Coast Guard found 43 bales containing 1,300 pounds of weed floating in the Pacific Ocean. And last spring, Alabama cops seized over 100 pounds of weed and coke, with a street value of over $1 million, that washed up on Orange Beach.


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Dutch begin new coalition negotiations
Dutch politicians began fresh negotiations Monday with a view to establish a four-way coalition government between the Liberal, Labour, Green parties and centrists, an official source said.
Queen Beatrix had asked advisors Uri Rosenthal and Jacques Wallage to look into the "rapid establishment" of a four-way coalition government, the royal press service said in a statement.
The formation of such a coalition had been shelved on June 22, but new discussions have taken place since, overseen by politician and royal advisor Tjeenk Willink.
In his report to the queen Monday, Willink said the four-way coalition government "has the greatest legitimacy according to the elections".
The coalition would not include the far-right, anti-Muslim Party for Freedom, which came third in the parliamentary elections on June 9.
The Liberal Party took 31 seats in the vote, followed closely by Labour with 30 seats, the Party for Freedom took 24 seats and the Christian Democratic Party were pushed to fourth place with 21.
The Socialist Party came fifth with 15 seats, and the centrist and green GroenLinks both took 10 seats.
A tie-up between Mark Rutte's Liberal party with Wilders' Party for Freedom, had been floated but scrapped on June 12.
Coalition negotiations, which analysts expect to be long and complex, could take weeks even months.
© 2010 AFP


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Hurricane Ike battered Texas, causing untold damage for millions of home-owners in Houston and Galveston. But some people in Chicago had a pretty bad weekend, too.
After raining all day on September 13 and 14, the Windy City became the flooded city. The far-reaching tendrils of the hurricane dumped 9 inches of rain in less than 24 hours. Roads and basements became water logged. The Chicago River overflowed in some parts, leading to the evacuation of about 300 homes. Flooding in Northwest Indiana led to the closure of Interstate 90.
Can we blame global warming for hurricane-related damage this far north and east? I think so….
At Progress Illinois, a blog post on flooding that occured this summer examines global warming and Midwest floods. Experts seem to think that global warming is certainly leading to more flooding. According to Gene Tackle, an Iowa State University professor quoted in this post, the Midwest will be experiencing more flooding: “There has been in the last 30 years a tendency toward more heavy rainfall events in the central U.S. We have a past trend and our models, based on increased greenhouse gases produced by humans, indicate that the trend will continue.”
So Chicago may be more than 1,000 miles from Texas, but it is still in harms way.
Photo courtesy of Jerry Poluzny at Flickr.


So everyone has accepted as common knowledge the following statement:
"A .22 makes for a poor choice as a self-defense weapon. This round is good for nothing but plinking and small varmint hunting."
Has anyone ever challenged that statement?
I will do that right here, right now.
I will not compare the .22LR round to any other caliber, because that is not my goal, and doing so would be counter-productive to learning. I want to share a few findings and thoughts with you, and you can make your own decision as to whether or not I have any validity to my statements, or if I'm just talking just for the sake of talking.
I will concentrate on the typical .22LR round, which is the 36 grain hollowpoint that travels at around 1280 FPS. This round is common in bulk, and is the most popular out there (at least in my area). If you want a step higher, you can go with the CCI Mini Mag, which is a 40 grain, solid projectile (better penetration, slightly heavier bullet).
Now the typical .22LR round (36 grain) has a pretty flat trajectory in typical self defense ranges (7-15 yards). This is a plus, because no matter the caliber, you want something that will fly where you want it to. You are responsible for 100% of the rounds you fire 100% of the time, and you don't want something that will fly off into neverland during a crucial moment.
The biggest argument is the stopping power of the .22LR round. There isn't much "punch" to the round at all, and a bad guy/gal may not know when he/she is shot, or will they? How does training figure into the effectiveness of such a small round such as the .22LR? Is it possible to drop someone before they maime/kill you with a .22LR firearm? Think about these questions carefully before you respond with an automatic answer, and while you are pondering these questions, resist the urge to compare the .22LR with a bigger SD round. Pretend for a second that the only round available is the .22LR round. What can you do to be effective with that round? We all know that the .22LR doesn't transmit energy like a 9x19mm or a .45 ACP would. The thing we always forget is the energy from a .22LR is sufficent to penetrate into the human center of mass, even when clothed. That means the .22LR does, in fact, have the ability to stop threats. There is sufficent evidence that the .22LR round will penetrate the chest cavity / skull with enough force to destroy live giving organs, rendering life impossible for the threat.
Another thing that many have overlooked is the lack of muzzle blast and mizzle rise from a typical .22LR firearm. Imagine being able to put all rounds into a tight center of mass grouping at 10 yards with minimal training. This, I believe, is the greatest advantage of the .22LR round. You can put follow up shots right behind the inital shot with very minimal effort on your part. No one will argue that 3 or more well placed shots into the breastbone of an attacker will have a negative impact on him, and a positive impact on you. If you are well trained, the use of the tried and true "2 to the chest, 1 to the head" can be performed with great ease, due to the lack of recoil.
Another positive factor is the availiability and low cost of the rounds. This is the greatest factor in the lack of firearms practice today. The more you practice, the better you are. Unfortunately, your disposable income determines how much you practice, not your willingness to be better.
I can go more in depth if any of you wish. I will state for the record that I am NOT claiming this round is any better than something like a 9x19mm, .45 ACP, etc.... I try to mirror the philosophy of Clint Smith, which is to train with what you have, not with what you wish you have. If all you can afford is a cheap .22LR handgun and some .22LR ammo, then you should be adopting a mindset of how you are going to use that combination to it's fullest potential. The person behind the weapon is the most deadly weapon system out there.
Here's a little setup I purchased for the total price of $75.00 out the door. It is a simple Jennings J22 (6 round capacity) with no frills. This weapon is known as a saturday night special, and has a horrible reputation, but it has preformed reasonably well for me (I fluffed and buffed it a little, so it runs near perfect with bulk ammo now - It runs 100% perfect with 40 grain loads).
Group at 10 yards from off-hand:
Size of the pistol in hand (it's almost funny to shoot because of it's size...lol):


You can change the number of pieces here (5-1200).
The Rio-Antirrio Bridge is the longest cable-stayed cable bridge with multiple spans in the world at 2,880 meters and lies over the Gulf of Corinth near the Greek city of Patras. The bridge is seen as a technical masterpiece because it is built on very difficult terrain with deep water, high risk of earthquakes, tsunamis and the widening of the Gulf due to plate tectonics.
When you don't see the puzzle, it is possible that we haven't uploaded it to our new puzzlehost yet.
Read here why the puzzles look different and which problems there can be


THE NEED FOR CLEAN INDOOR AIR
Critical Importance of Indoor Air Quality (IAQ)
In commercial office buildings, Indoor Air Quality (IAQ) is a primary concern. IAQ refers to the quality of indoor air breathed in by a building’s occupants. The pollution levels in this indoor air can be up to five times higher than outdoor levels, and poor IAQ ranks as one of the top five environmental risks to public health. Now more then ever, making sure that the circulated air is clean, and that occupants are protected, is vital.
The Air Inside Your Building Man Contain:
Higher-efficiency air filters help protect against airborne contaminants as well as pathogens, such as bacteria and viruses. ASHRAE and the CDC both suggest upgrading the particle efficiency of air filters and cycling more outdoor air into commercial buildings as a means of protecting building occupants. Specifically, air filters rated at least MERV 13 are recommended to reduce the presence of these disease- and infection-causing contaminants in occupied spaces.
Besides particulate filters, gas-phase filtration must be used to control the harmful effects of gaseous contaminants in commercial facilities. Common sources of these contaminants are located both outside and inside commercial facilities, ranging from automotive exhaust, weather-related conditions, and wildfires outside buildings to paint, carpet, and furniture inside facilities.
Optimize Your Environment
Air filtration systems in commercial facilities must handle relatively large volumes of air. Approximately 50% of a building’s energy consumption goes to the heating, cooling, and moving of air. Proper filter selection and maintenance is essential to keeping HVAC systems operating effectively and efficiently. There are multiple facets of the filter and the system in which it is installed that must be taken into consideration. These considerations include system airspeed, fan efficiency, filter resistance, service life, efficiency and cost. In considering the Total Cost of Ownership (TCO), it is important to keep in mind that planning maintenance is an important step in maintaining energy efficiency, minimizing costly downtime, and extending the lifespan of your equipment, thereby ensuring a cost-effective building.
Proper Air Filtration Strategies Improve Sustainability and Contribute to Four of Six LEED Credit Categories:


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Ten critical firefighting aircrafts have arrived in north-east Victoria and will be stationed at bases across the region, ready to respond to fires in preparation for the peak bushfire season.
The aircraft will be used by Forest Fire Management Victoria and the CFA to respond to bushfires in the region and across the state.
FFMVic assistant chief fire officer Aaron Kennedy said the aircrafts were an essential tool in supporting ground crews to contain fires before they spread and impact communities.
‘‘As soon as a fire is reported, an aircraft will be deployed at the same time as the fire trucks, giving firefighters a greater chance of limiting the size and spread in the early stages,’’ he said.
‘‘Immediate response is one of the most effective ways to help stop the spread of fires and helps keep communities safe this bushfire season.
‘‘There are 49 aircrafts in the state’s base fleet, consisting of fixed wing planes, helicopters, air tankers and large air cranes that will be ready to respond to fires.’’
Mr Kennedy said north-east Victoria had never been better equipped to handle what was looming as a dangerous fire danger period due to dry conditions.
‘‘This summer we are facing an increased risk of bushfires due to the underlying dryness on both public and private land,’’ he said.
‘‘However, our region is well resourced and prepared to respond to bushfires.
‘‘For the first time Victoria will have two night vision enabled aircraft joining the fleet and one of them will be based in our region at Mangalore, near Avenel.
‘‘Night firebombing will be used as an extension of day operations, meaning aircraft will be able to assist ground crews on fires for longer when conditions are suitable.’’
The aircrafts are based at Benalla, Mansfield, Shepparton, Mangalore, Ovens and Albury, but can move to other locations depending on weather and bushfire risk.


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Blue Sapphire Films is set to release ‘Forever’, a film by Vinay Ram Tiwari.
The film stars Rakesh Bapat, Nisha Aaliya, Michael Roy Andrew and Ashwini Chopra. ‘Forever’ encapsulates the enthralling and magical love story of Sanam and Shinara. The world is non – existential for Sanam and Shinara as they are each other’s world. They are spellbindingly beguiled by each other until reality hits them hard. Unabashedly and blindly in love they are unable to foresee forthcoming events that shatter their lives forever. They were breathing for each other until Shinara is forced to stop breathing.
Devastated Sanam wanders about lifelessly with a bleeding heart and a broken soul. He searches for her even within his memory lanes but she is lost ‘Forever’. He is unable to come to terms with the bitter truth, until one day he astonishingly discovers that Shinara is still breathing somewhere. Sanam is resurrected to encounter the truth but he needs to unearth the dark mystery that awaits him. He is shocked to find out the presence of a third person in Shinara’s life. Watch “FOREVER” to know what happens next. Is Sanam able to live with Shinara in their enchanted world or is he compelled to make peace with his current reality?
‘Forever’ releases this March in the UK.