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A pyrrhic victory is a term for “a victory won at too high a cost”. As a leader, it is important to avoid pyrrhic victories. What really is a pyrrhic victory? A pyrrhic victory is a victory that comes with a devastating cost that ultimately nullifies the victory that has been achieved. Someone who wins a pyrrhic victory has been victorious, but the price of the victory can make him wish he had never won that fight.
The phrase “pyrrhic victory” came from a war between the Greeks and the Romans. King Pyrrhus of Epirus (north-western Greece) fought and defeated the Roman army. King Pyrrhus defeated the Romans at Heraclea in 280 BC and in Asculum in 279BC. Originally, Pyrrhus, king of Epirus in Greece, believed in the “win at any cost” battle strategy. However, by the end of his life, he had learnt that 'win at any cost' is not the best strategy.
“If we are victorious in one more battle with the Romans we shall be utterly ruined.” King Pyrrhus
Even though he had won two famous battles against the Romans, he knew that these victories were actually ruining him. A pyrrhic victory is often not worth having!
Then Judas, which had betrayed him, when he saw that he was condemned, repented himself, and brought again the thirty pieces of silver to the chief priests and elders, Saying, I have sinned in that I have betrayed the innocent blood. And they said, what is that to us? See thou to that. And he cast down the pieces of silver in the temple, and departed, and went and hanged himself.
Judas Iscariot got his thirty pieces of silver all right. You could say that Judas was a successful businessman who had landed himself a very good deal. But at what price did he get this money? It cost him his position among the twelve apostles. It cost him his ministry and it cost him eternity.
Napoleon's Pyrrhic Victory
Napoleon's destruction began with a pyrrhic victory that he won in Russia. Technically speaking, Napoleon defeated the Russians and entered Moscow. But by the time he got back to France, his army was virtually destroyed, leaving him severely weakened and unable to maintain his power base.
When Napoleon invaded Russia, the Russians recognized his strength and began to retreat into Russia so that they could avoid a confrontation. As Napoleon's army was forced deeper into Russia, he became entrenched in a long war that he had not really prepared for. Persistent hunger and long distances from the supply lines caused Napoleon's army to be severely weakened.
The Russians eventually decided to take on Napoleon on the 7th of September 1812, in a town called Borodino near Moscow. The Battle of Borodino would decide whether Napoleon would be able to enter Moscow and claim it!
Over 250,000 men went to war in what was the largest and bloodiest single day of Napoleon's wars. It seemed as though all hell had been set loose. At a point the Russian field marshal, Kutuzov, refused to weaken his army any further by continuing to fight. He retreated from the battle, leaving Napoleon free to take Moscow. Over 70,000 men were killed in the horrific Battle of Borodino.
Napoleon, with a severely weakened army marched into Moscow and found it empty. Everyone had fled. The Tsar of Russia and all the citizenry had fled Moscow leaving an empty city for Napoleon to rule over. Before the Tsar and others left, they released all prisoners of Moscow to burn down the city. Napoleon spent a month in Moscow waiting for the Tsar to return so that he would kneel down before Napoleon and declare him victorious but this never happened.
After a month with no one to confront, Napoleon was forced to retreat from Moscow and march through the harsh and dangerous winter to France. On the long march back, his army was attacked by the Russians who had been in hiding. The hungry, cold and severely weakened French men were thoroughly harassed, attacked and destroyed on their long march back to France. Napoleon himself came under attack during the journey back to France and had to escape for his very life.
Yes indeed Napoleon won the battle of Borodino. Yes Napoleon entered Moscow. But at what cost? Out of 286,000 soldiers who marched confidently into Russia, only 23,000 remained alive and crossed back into France. From then on, Napoleon's Grand Army was only a weakened version of what it had been. That was the beginning of the demise of Napoleon. Napoleon's victory was a pyrrhic one. During his exile many years later, Napoleon wrote that of the 50 battles of his life, Borodino was where “the greatest valour was displayed and the least success gained”. If you are a leader learn this lesson – avoid a pyrrhic victory!
By Dag Heward-Mills

domain: history


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The holiday season will soon be upon us, as will the frigid weather in some locales. It’s the time of year when patrons will enter your bar, some decked out in winter coats and red cheeks looking for a quick warm-me-up, while others come in simply looking for something seasonally inspired to warm their spirits. Turn up the heat with winterized variations on their favorite cocktails.
Winter Holiday Greenhouse Sangria
- 1 apple
- 1 Asian pear
- 1 nectarine
- 1 cinnamon stick
- 1 bushel mint (chocolate, apple, spearmint and peppermint)
- 1 bushel lavender
- 1 bushel pineapple sage
- ¼ cup simple syrup
- ¼ cup Grand Marnier
- ¼ cup Champagne
- 1 bottle red wine (recommended: Carchelo Tinto)
- ½ cup apple cider
Thinly slice all fruit. Heat lavender, mint, pineapple sage and cinnamon with wine in a saucepan for 20 minutes over a low simmer. Combine all ingredients together in a pitcher and steep for 24 hours. Double the recipe with every bottle of wine added.

domain: food


Cedar Rapids Police Investigating Another Homicide
Following Thursday's arrest of a juvenile in the shooting death of a Cedar Rapids teenager over the weekend, Cedar Rapids police are now investigating another death in the city last night.
Cedar Rapids police report being called to a disturbance and possible shots fired last evening in the 1000 block of G Avenue Northwest just after 8 pm. When they arrived, officers found a 32-year old man had been shot. He was taken by ambulance to a local hospital and died during surgery. His death is now being investigated as a homicide.
The Cedar Rapids Police Department doesn't believe last night's shooting was a random act or that there is a risk to the public. Cedar Rapids Police Chief Wayne Jerman made the following statement: "We appreciate the many people who continue to express their support for the police department and have provided information to help us solve these crimes. Last night's homicide was not a random act. In many violent incidents, there is a pattern of risky behavior, including association with convicted criminals and participating in criminal activity, which jeopardizes personal safety. The Police Department will continue to be diligent in promoting safe neighborhoods by assigning additional police officers to the streets, increasing officer visibility, enhancing outreach efforts, and utilizing other non-conventional methods."


A Medical Device Daily
Hospitals in Louisiana and Mississippi still working to recover from the Hurricane Katrina disaster will receive $19.1 million in additional assistance from the Department of Health and Human Services (HHS).
"HHS continues to work with those in need to resolve the healthcare problems created by Hurricane Katrina," HHS secretary Mike Leavitt said. "This grant is another step we are taking to make sure the citizens of these states have continued access to medical services."
Three years after the two hurricanes devastated the Gulf Coast, many state healthcare delivery systems still are attempting to rebuild. To date, HHS has provided the region with more than $2.5 billion to assist in funding for social services, healthcare, and efforts to rebuild the healthcare system in the states hardest hit by the storms.
This grant is targeted specifically to Louisiana and Mississippi to support their hospitals and inpatient psychiatric facilities (IPFs) that are facing serious and ongoing financial pressure to compete for workers in highly competitive post-storm labor markets.
After the storm destroyed housing and other critical infrastructure in cities such as New Orleans, thousands of residents fled to other states and many have not returned. This has created stiff competition among employers to attract and retain workers. HHS said rebuilding healthcare delivery systems in these communities is vital to the renewal of these devastated communities.
HHS said this grant will help support provider operations until the Medicare prospective payment system can adjust for changes in local wage scales.
States will have discretion to determine which hospitals and IPFs and/or regions are still experiencing the most post-Katrina difficulties and will receive grant funds. Facilities, however, must be located in counties or regions which continue to be designated by the Federal Emergency Management Agency as eligible to receive individual and public assistance.


ANDOVER BOROUGH, NJ (Sussex County) — Two people were flown to the hospital after a crash in Andover Borough Sunday morning, state police said.
It happened at 7:14 a.m. on Route 206 at mile marker 102.5, state police said.
According to state police, a preliminary investigation revealed a Volkswagen, driven by Enrico A. Stampone, 26, from Totowa, was traveling north on Route 206 when his vehicle crossed the yellow center line into the southbound lane and struck a Hyundai SUV, driven by Melissa J. Vanorden, 43, from Budd Lake.
Both suffered serious injuries and were airlifted to Morristown Medical Center, state police said.
No further information was available.


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Pedestrian accidents are devastating for the victims. It is imperative that you seek medical care if you are ever on foot and get struck by a vehicle. The issue here is that the human body isn’t made to withstand the impact of heavy steel slamming into it.
When you get hit by a vehicle, you might opt to seek compensation. This can help you cover the cost of your medical care and other expenses. You should think carefully about this soon after the accident. You have two years in California to file your legal claim. We are here to help you initiate your claim.
The impacts of a car crash involving a pedestrian can vary greatly depending on the circumstances. Victims of high-speed crashes might have more serious injuries than those who are involved in low-speed crashes. The location of impact may also affect the severity of the injuries.
We realize that you can face many unfamiliar challenges after being hit by a car. Your primary focus should be trying to heal from your injuries so that you are able to reclaim your life. This may not be easy if you suffered serious, life-changing injuries, but it can be be helpful to learn all that you can about the consequences of your injuries. Sometimes, catastrophic injuries to the spinal cord or brain can lead to a lifetime of challenges.
Seeking compensation won’t help you overcome these challenges but it will help you afford to cover the costs associated with your treatment, recovery and rehabilitation. Contact our firm to learn how we can best assist you.

domain: medical


From Gurdip Singh
Bogor (Indonesia), Dec 10 (PTI) The South China Sea (SCS) should not become a battlefield between big countries, Indonesian President Joko Widodo today said, as he expressed willingness to facilitate talks between the states involved in the dispute to resolve the issue peacefully.
"We do not want this region to become a battlefield between big countries. Economic costs will be too expensive if there is a conflict (in this region)," Widodo told PTI.
Underlining the importance of peace in the worlds busiest shipping routes, he said that "all disputes must be resolved peacefully... There must always be respect for diplomatic and legal processes."
China claims nearly all of the strategically vital SCS -- a vast tract of water through which a huge chunk of global shipping passes. It has bolstered its claim by building artificial islands including airstrips in the area, some of which are suitable for military use.
The Philippines, Taiwan, Brunei, Malaysia and Vietnam have competing claims to parts of the SCS, which is believed to harbour significant oil and gas deposits.
Tension often builds up between these claimant states to Spratlys, a group of 14 islands, islets and reefs in the SCS.
In July, an international tribunal struck down Chinas claims of "historical rights" in the SCS, prompting Chinese President Xi Jinping to reject its ruling.
President Widodo, who is widely known as Jokowi, said Indonesia is not a claimant state but the SCS issue is complicated.
"I believe the states that are involved in the dispute can solve this problem.
Indonesia is ready to facilitate," Widodo said ahead of his visit to India next week.
"Indonesia continues to actively prevent these problems from becoming a source of conflict as peace and stability must prevail (in the region)," he said.
Indonesia, he assured, continues to accelerate the preparation of the Code of Conduct between China and ASEAN.
China is Indonesias top import source and second biggest export destination for items such as minerals and palm oil.
Except for Brunei, the other five claimants have structures on some of the islands which ranges from hosting of flags to an airstrip by China and fuming over presence of naval ships to fishing boats.
The US, an allied partner with some of the claimant states, has called for peaceful resolutions to the disputed island issues in the SCS. PTI GS ZH


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Kenneth S. Reiss, DO
Kenneth S. Reiss, D.O., family medicine physician, received his Bachelor of Science in Microbiology at University of Florida in Gainesville, Florida. He went on to earn his Doctor of Osteopathic from Nova Southeastern University College of Osteopathic Medicine, in Davie, Florida.
Dr. Reiss completed his Family Medicine Internship and Family Medicine Residency at North Broward Hospital District in Fort Lauderdale, Florida.
Dr. Reiss is a member of American Osteopathic Association and a member of American College of Osteopathic Family Physicians. He welcomes you to his location.


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Lots of Compassion Grant
Deadline: June 2, 2023
Mrs. Meyer’s Clean Day and KidsGardening announce their new Lots of Compassion grant program, designed to support local leaders looking to transform vacant lots into gardens to help grow compassion in their community. In 2023, 10 grantees will receive $20,000 each to transform a vacant lot into a garden.
Danone Institute of North America Requests for Proposal for Sustainable Food Systems Initiatives
Deadline: June 14, 2023
Danone Institute North America (DINA), a nonprofit foundation managed by Danone North America announced a request for proposal for the third offering of its DINA Sustainable Food Systems Initiative. The biennial competitive grant is now accepting submissions from eligible applicants in the U.S. and Canada. The 2023-2025 initiative commits a total of $260,000 in funding, its largest contribution yet, for up to five transdisciplinary teams who demonstrate a commitment to actionable and achievable projects that sit at the intersection of community, health of people, and health of the planet. Selected grantees will be challenged to design, implement and evaluate actionable community-based projects for sustainable food systems that improve human health and nutrition over a two-year period. Each of the five finalists will receive $50,000 to support and expand their project. An additional $10,000 will be granted to the team with the strongest communications plan, awarded in the fall of 2023.

domain: news


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Follow the white rabbit down the hole into our Wonderland. You won't find Alice or The Mad Hatter, but you will find new friends, pretty tags, & fun activities.
Based on Sword Art Online, the 'Tales of' Series, and Japanese RPGs. People are kidnapped and inserted into a virtual reality world, where they must fight to escape or die trying.
There is no more division between where you can and cannot travel. World blurs into world as you reach across galaxies, searching for something beyond...
Vylon Dueling Academy is here to help our members meet new duelists, have fun, and make them into the best duelists they can be!
Free forum : Journey with us and discover our family as we look more at mystical subjects including tapping into the intuition and unlocking our inner mystic.
Covering the newest iphone/ipod games with reviews, photos, and more. Get a look into todays hottest games and peek into the future games. Mingle with developers, get latest info, and conversate with fellow gamers.
Intimate forum for beginner, intermediate, and experienced writers whose goal is skillful, lucrative transition into freelance professional copywriting.
Cross Academy. A place where vampires and humans alike attend the same school seperated into two classes. The night class and the day class. The night class has a secret. A secret the day class must never find out. The night class is full of elite va
This is a role playing forum for those who love this fandom and wish to immerse themselves into the avatar universe.
This is the forum of our region, the Imperial Crimson Republic! This is where all of our internal affairs shall be conducted. This forum shall be divided into sects.
To help us discuss and dig deeper into the subject matter of "Finally Free".
Free forum : Jump into the world of F. A. T. E. A new text-based RP forum for you and your friends to challenge a wide array of monsters and beings in an epic Fantasy, anime RPG!
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Welcome to Sailor Moon Revelations! We are an AU Sailor Moon RPG looking for talented writers who are looking for a place where they can have fun as well as dive deeper into characters we all know and love. We are an advanced RPG and are looking for
This forum is designed to accommodate investigations into gang activity related to popular sport fish.
Free forum : Hello welcome to AninationGaming! this fourm will be used for the upcome AninationGaming Darkrp server. Alot of hard work will be put into this so sit back and enjoy
Garry's Mod Star Wars Serious RP community. Friendly, open community for anyone who's a fan of Star Wars, along with those just looking to get into it.
Accelerate with your own character into Brain Burst!
A unique, fun non-canon Naruto Roleplay that freely incorporates new ideas into the over-saturated Naruto forum market.
how to turn 6 dollars into thousands of dollars risk free
SAK clan is a stunters and deathmatchers clan, whose members mix those activities into one original and unique gameplay style.
Free forum : Evernight Academy is an academy with Vampires and humans together, it is rare that the vampire slayer is accepted into Evernight but with their sleek expertise, they can do anything. You
Once the light of the moon touches our skin, we transform into the monsters that keep the humans from entering our territory. That is what we are. We are the pack.
Ball and Chain is a 10 member, no-nonsense Dynasty Fantasy Football League with a small buy-in, entering into its second season of action.
A massive bard board game combining aspects of Risk, Settlers Of Katan, And Civilization to blend into a very strategic all-out war game for up to 20 players!
This is a site welcome to any person(s) looking for an adventure and dip into the medieval lifestyle. All members are welcome as long as the rules are followed.

domain: entertainment


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To investigate whether pigmentation genes involved in the melanogenic pathway (melanogenesis) contributed to melanoma predisposition, we compared pigmentary genetics with quantitative skin pigmentation measurements, the number of atypical nevi, the total nevus count, and the familial atypical multiple mole and melanoma (FAMMM) syndrome. We typed 32 pigmentary SNP markers and sequenced MC1R in 246 healthy individuals and 116 individuals attending periodic control for malignant melanoma development, 50 of which were diagnosed with FAMMM. It was observed that individuals with any two grouped MC1R variants (missense, NM_002386:c. 456C > A (p.TYR152*), or NM_002386:c.83_84insA (p.Asn29Glnfs*14) had significantly (p<0.001) lighter skin pigmentation of the upper-inner arm than those with none or one MC1R variant. We did not observe any significant association of the MC1R variants with constitutive pigmentation measured on the buttock area. We hypothesize that the effect of MC1R variants on arm pigmentation is primarily reflecting the inability to tan when subjected to UVR. A gender specific effect on skin pigmentation was also observed, and it was found that the skin pigmentation of females on average were darker than that of males (p<0.01). We conclude that MC1R variants are associated with quantitative skin colour in a lightly pigmented Danish population. We did not observe any association between any pigmentary marker and the FAMMM syndrome. We suggest that the genetics of FAMMM is not related to the genetics of the pigmentary pathway.
Citation: Johansen P, Andersen JD, Madsen LN, Ullum H, Glud M, Børsting C, et al. (2016) Pigmentary Markers in Danes – Associations with Quantitative Skin Colour, Nevi Count, Familial Atypical Multiple-Mole, and Melanoma Syndrome. PLoS ONE 11(3): e0150381. https://doi.org/10.1371/journal.pone.0150381
Editor: Amanda Ewart Toland, Ohio State University Medical Center, UNITED STATES
Received: September 25, 2015; Accepted: February 12, 2016; Published: March 3, 2016
Copyright: © 2016 Johansen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Data Availability: Data may compromise the privacy of study participants and may not be shared publicly. Data are available upon request to the authors.
Funding: The authors received no specific funding for this work.
Competing interests: The authors have declared that no competing interests exist.
Human skin colour is greatly influenced by environmental factors, including ultraviolet radiation (UVR). UVR is high in equatorial regions of the world, where darker skinned populations are found, and lower in regions distant to equator, where lighter skinned populations are found . Excessive UVR of the skin induces DNA damage and is considered one of the main risk factors of developing various skin cancers. Dark skin, with high levels of the pigment eumelanin, protects against UVR, because eumelanin block the effects of UVR. On the other hand, vitamin D synthesis requires UVR and human skin colour diversity reflects the balance of letting enough UVR through the skin to produce vitamin D and preventing DNA-damage caused by UVR .
Melanin is produced in melanosomes, which are lysosome-related organelles present in melanocytes. Two types of melanin are produced, pheomelanin (yellow/red) and eumelanin (brown/black). Pheomelanin levels are rather constant among people with different skin colours whereas eumelanin levels vary . Eumelanin is more efficient than pheomelanin in blocking UVR and in scavenging the reactive oxygen species produced from UVR of the skin (reviewed in ). Pheomelanin confers a carcinogenic risk in mice independently of UVR . Melanocytes are found in the basal layer of the skin together with keratinocytes and the two cell types form the epidermal melanocyte unit . Keratinocyte cells function as the primary barrier against environmental damage, including UVR. DNA damage in the keratinocyte induces expression of tumour protein p53 (P53), which induces melanin synthesis by increasing the level of α-melanocyte stimulating hormone (αMSH) that binds to the melanocyte-membrane-bound melanocortin 1 receptor (MC1R) and increases the cAMP level in the melanocytes. This results in increased transcription of several pigmentation genes via microphtalmia associated transcription factor (MITF) (reviewed in ).
Many of the key genes involved in the melanogenic pathway are associated with skin colour and skin cancer risk including agouti signalling protein (ASIP), oculocutaneous albinism 2 (OCA2), solute carrier family 45 member 2 (SLC45A2), tyrosinase (TYR), tyrosinase-related protein 1 (TYRP1), and melanocortin 1 receptor MC1R [8–17]. Variants in the MC1R have been studied extensively in relation to the risk of developing various skin cancers [18–21], and certain MC1R variants are associated with increased survival of melanoma patients . Mutations in MC1R cause the red hair colour phenotype that is characterized by red hair, fair skin, and inability to tan [23–27]. Mutations in MC1R may result in either diminished α-MSH binding or decreased cAMP signalling resulting in decreased production of eumelanin.
UVR exposure is a major health risk factor, especially in light skinned populations [28,29]. Lightly pigmented skin and a large number of atypical nevi is associated with increased risk of developing malignant melanoma [11,30–33]. Atypical nevi are more prevalent in melanoma patients from light than from dark skinned populations . The grade of cytological atypia of the nevi is an important risk factor for the development of malignant melanoma [35,36]. The familial atypical multiple-mole and melanoma (FAMMM) syndrome is defined by (1) occurrence of melanoma in one or more first or second degree relatives, (2) large numbers of moles (often greater than 50) some of which are atypical and often variable in size, and (3) moles that demonstrate certain distinct histologic features [37,38]. Genetic mutations have been identified in melanoma prone families including mutations in cyclin kinase 2A (CDKN2A) and cyclin kinase 4 (CDK4) genes, both of which encode proteins involved in the retinoblastoma pathway [39,40]. Genetic variants of CDKN2A are associated with the number and distribution of atypical nevi .
MC1R variants can modify the penetrance of CDKN2A mutations, as carriers of mutations in both genes are at increased risk of developing malignant melanoma compared to individuals carrying a mutation in only one gene [31,39,42–47].
Many nevi, including common nevi, harbour the V600E mutation in the v-raf murine sarcoma viral oncogene homolog, B1 (BRAF) . V600E was observed in 60% of all melanomas . BRAF can regulate melanoma proliferation through MITF  that is a transcription factor and regulator of pigmentation.
Even though high melanoma risk alleles clearly exist in e.g. CDKN2A, it is speculated if the melanoma risk might be attributable to combinations of low to moderate risk alleles in e.g. MC1R, TYR, and ASIP .
In this study, we investigated the associations between SNPs in pigmentary genes and (1) quantitative skin colour measurements in 246 healthy, light skinned Danish individuals, (2) total nevi, (3) total atypical nevi count, and (4) the FAMMM syndrome in 116 Danish individuals at increased risk of developing malignant melanoma.
Associations between quantitative skin colour and genetic markers
The Pearson correlation coefficient between logarithmic transformed arm and buttock PPF measurements was 0.51 (r2 = 0.26, data not shown). Buttock PPF measurements were statistically significantly lower than those of arm measurements for both genders in the cohort group (p<2.3x10-16). The skin was signifcantly darker in females than in males among the cohorts at both measurement sites (p<0.001, Figs 1A and 2B). Furthermore, female cases had statistically significantly higher arm PPF measurements than male cases (Fig 1C). However, we did not detect any statistically significant difference between the buttock PPF measurements of males and females in the case group (Fig 1D). Female cases had significantly lighter skin on the buttock than female cohorts (p = 0.0004). However, this tendency was not observed in males (p = 0.7), and there was no significant difference in the pigmentation levels on the arms between cases and cohorts in either sex (p = 0.8 and p = 0.9 in females and males, respectively).
Arm (A) and buttock (B) measurements in females and males of the cohort. Arm (C) and buttock (D) measurements of female and male cases. P-values were calculated using Welch’s two sample t-test.
Influence of genetic variations, gender, age, and month of measurement on PPF
Individuals from the cohort group with two or more MC1R variants (missense, p.TYR152*, or p.Asn29Glnfs*14, S2 Table) had statistically significantly lower PPF measurements of the arm (Fig 2) than those having one or no MC1R variant. We did not observe this relationship for buttock measurements (data not shown). We performed multi linear regression model analysis of the cohorts (n = 246) with log10(PPF) as response and gender, age, month of measurement, 22 SNPs with sufficient observations, and MC1R variants as explanatory variables (Pane 1 S3 Table and Pane 2 S3 Table). For arm measurements, we only observed grouped MC1R variants to deviate statistically significantly (p<0.01). The MC1R association was not observed when investigating a similar multi linear regression model with buttock PPF as response. Among the tested variables, only gender was statistically significantly associated (p<0.01) with the buttock PPF.
Associations with nevi and FAMMM
We evaluated the logistic regression model including age, gender, 22 SNPs, and MC1R for association with nevi count (Pane 3 S3 Table). A statistically significant association with total nevi count prior to correction for multiple testing was observed for the G and AG genotypes of rs6475555 on chromosome 9 (non-corrected p = 0.004 (corrected 0.18) and p = 0.005 (corrected 0.24), respectively). None of the parameters were statistically significantly associated with the total nevi count after correcting for multiple testing.
When evaluating a logistic regression model with atypical nevi count as response (Pane 4 S3 Table), we observed statistically significant association with age (p<0.05). Healthy cohorts had a mean age of 45.1, years and cases with atypical nevi had a mean age of 38.4 years, which may explain the statistically significant results of the model. The G and GA genotypes of rs1015362 in ASIP were statistically significantly associated with the atypical nevi count prior to correction for multiple testing (non-corrected p = 0.008 (0.36 corrected) and p = 0.003 (0.13 corrected), respectively).
When performing the logistic regression model including FAMMM (Pane 5 S3 Table), we observed a statistically significant association with age. This was most likely caused by the fact that patients with FAMMM had a mean age of 36.9 years, whereas the healthy cohorts had a mean age of 45.1 years. We did not observe any statistically significant association between the 22 SNPs or MC1R with the FAMMM syndrome, allthough that we prior to Bonferoni correction observed statistically significant associations with the vitamin D receptor (VDR) SNP rs1544410 G and the agouti signalling protein (ASIP) SNP rs1015362 G (non-corrected p = 0.007 (0.33 corrected) and p = 0.009 (0.43 corrected), respectively).
The measurements of pigmentation levels demonstrated that the buttock area was statistically significantly less pigmented than the upper-inner arm area. This implies that the buttock is a better site for measuring constitutive pigmentation levels than the upper-inner arm, and that the upper-inner arm measurements often reflect the tanning response of the individuals. We observed a statistically significant difference of the logarithmic transformed PPF values between males and females of the cohort group on both arm and buttock. This observation supports previous observations in eye colour studies indicating that there may exist a yet unknown biological, sex-determined mechanism controlling pigmentation levels [52,53]. On the other hand, the darker skin pigmentation levels observed in females could also be an environmental effect due to e.g. different sun or clothing habits (Fig 1A and 1B). The individuals in the case group are expected to avoid extensive UV-exposure. In this group, females and males did not have statistically significantly different PPF values of the buttock (Fig 1D), and the effect of gender on the arm pigmentation was less pronounced (Fig 1C). This seemed to indicate that the observed gender effect on pigmentation wass caused by an environmental effect.
When performing multi linear regression analysis among the cohorts, we observed that individuals with two or more MC1R variants had statistically significantly lower PPF values of the arm than those with none or one MC1R variants. MC1R variants were not statistically significantly associated with PPF measurements on the buttock. This shows, in concordance with established genetic theories concerning MC1R (reviewed in ), that MC1R variants are involved in human pigmentation. Since MC1R variants are not statistically significantly associated with pigmentation measurements of the buttock, we hypothesize that the effect of MC1R variants on arm pigmentation is primarily reflecting an inability to tan when subjected to UVR. Two of the genotypes of rs6475555 on chromosome 9 were, prior to correction for multiple testing, statistically significantly associated with the total nevi count. This SNP was previously found to be associated with the total nevus count in a study comprised of twins from the UK and twins of European ancestry in Australia . Falchi and colleagues hypothesized that the gene methythoiadenosine phosphorylase (MTAP) or the adjacent CDKN2A gene are involved in the nevus formation . A SNP in MTAP was reported to be associated with an increased number of nevi  indicating the importance of the MTAP region in nevus formation.
Two of the genotypes of ASIP rs1015362 were, prior to correction for multiple testing, found to be statistically significantly associated with the atypical nevi count. ASIP was described as being associated with skin colour and melanoma risk .
Neither the tested SNPs nor MC1R was statistically significantly associated with FAMMM after correction for multiple comparisons. This most likely reflects that FAMMM is caused by defects in non-pigmentary systems, e.g. the retinoblastoma or P53 pathways [39,40]. It is possible that the atypical nevi observed in these individuals are by-products of signalling through MITF rather than being caused by a specific function of the pigmentary system.
Material and Methods
Samples and DNA purification
Blood samples from 362 unrelated Danish individuals were collected. A sample of 246 healthy individuals (cohorts) was collected at the Section of Forensic Genetics, Department of Forensic Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, and at the Blood Bank, Glostrup Hospital. Blood samples from 116 individuals (cases) were collected at the Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark. The case group contained individuals attending regular inspection at the Department of Dermatology at Bispebjerg Hospital due to an increased risk of developing malignant melanoma. Not all case group individuals had a definite diagnosis. All individuals in the case group were evaluated by a trained dermatologist. Nevi count (> 50 or<50) and atypical nevi count (> 5 or < 5) were evaluated by the Dermatologist. Atypical nevi are large nevi (>5mm in diameter) with irregular borders and colour variations. Cases were heterogeneous and presented multiple indications; 71 cases had more than 5 atypical nevi and 59 cases had more than 50 nevi. Fifty cases were diagnosed with FAMMM using the following criteria; 1) 100 or more melanocytic nevi, 2) one or more melanocytic nevi greater than or equal to 8mm in its largest diameter, and 3) one or more clinically atypical melanocytic nevi (clinically defined entities, >5 mm in diameter, with irregular pigmentation and an irregular or diffuse edge), according to the description defined in .
The individuals in the cohort group were asked to fill in a questionnaire and answer if they had more than five large nevi (>5mm) on their skin. Individuals in the cohort group that reported more than five large nevi were excluded from the study of atypical nevi and FAMMM, as these individuals may represent undiagnosed case individuals. Individuals in the cohort group that reported less than five large nevi were classified as belonging to the non-FAMMM and the low nevi count category groups. This left 159 cohort individuals (87 provided no nevi information) and 116 case group individuals for analysis of nevi and FAMMM and a total of 246 cohort individuals and 116 cases for analysis of quantitative skin colour (Table 1).
F: females. M: males. Sd; Standard deviation.
DNA was purified from 200μL whole blood using the DNA Blood Mini Kit (Qiagen) as recommended by the manufacturer. DNA was eluted in 50μL AE Buffer (Qiagen). Blood samples were collected between March 2010 and January 2012. Samples were grouped by the month of collection, regardless of year, in order to analyse the possible seasonal variation in quantitative skin reflectance measurements.
The study was approved by the Ethical Committee of the Capital region of Denmark, H-4-2009-125 and M-20090237. All participants provided written informed consent. All individuals included in the study reported Scandinavian parental origin. Individuals did not report regular use of tanning beds.
Skin reflectance measurements
The quantitative skin reflectance measurements were performed using a UV-Optimize Scientific 555 (Chromo Light APS, Espergærde, Denmark). The instrument is a non-invasive spectrophotometer that calculates the reflectance of skin redness and pigmentation from the measured area in percentage . The instrument was calibrated with a white standard (ISO 2469).
The reflectance of a wavelength at 555nm measures the haemoglobin content and is scaled as 0%-100% skin redness. Null percent skin redness corresponds to skin without blood, and 100 percent corresponds to highly vascular skin lesions. The reflectance of 660 nm indicates the melanin content termed skin pigmentation when the skin redness is eliminated. A null percentage skin pigmentation measurement corresponds to the reflection of no pigmentation (pale), and a 100 percentage skin pigmentation measurement corresponds to the reflection of black skin . The pigment protection factor (PPF) is a value for the protection against UVR provided by skin pigmentation and the top layer of epidermis (stratum corneum). The PPF can be used in parallel with the Fitzpatrick skin types . Measurements were performed on the upper, inner arm and on the buttock in triplicates for each participant. The medians of each PPF triplicates were used for statistical analyses. All measured skin areas were free from nevi, freckles, tattoos, and hair.
All 362 samples were typed for 32 SNPs, which were chosen based on their associations to various skin malignancies and skin colours (S1 Table), using the iPLEX® Gold kit (Sequenom) (S1 Table). The PCR contained 2μL DNA, 0.5μL 10x Buffer, 0.8μL 25mM MgCl2, 0.1μL 25mM dNTP mix, 1.3μL 0.5μM primer mix (DNA Technology), 0.2μL 5U/μl HotStarTaq, and 1.1μL H2O. The PCR was performed in a GeneAmp® PCR system 9700 thermal cycler (Applied Biosystems) with the following conditions: denaturation at 94°C for 2 min followed by 45 cycles of 94°C for 20 s, 62°C for 30 s, 72°C for 1 min, followed by 72°C for 3 min. The PCR products were treated with Shrimp Alkaline Phosphatase (SAP) (Sequenom) in a GeneAmp® PCR system 9700 thermal cycler at 37°C for 40 min and 85°C for 5 min. The SBE reaction contained 8μl SAP treated PCR products and 2μl iPLEX® mix (Sequenom). The iPLEX® mix contained 0.2μL 10x iPLEX® buffer, 0.2μL iPLEX®-Termination mix, 0.94μL primer mix (DNA Technology), 0.04μL iPLEX® enzyme, and 0.62μL H2O.
The SBE reaction was performed in a GeneAmp® PCR system 9700 thermal cycler with the following conditions: denaturation at 94°C for 30 s followed by 40 cycles of 94°C for 5 s, 52°C for 5 s and 80°C 5 s, 52°C for 5 s and 80°C for 5 s, 52°C for 5 s and 80°C for 5 s, 52°C for 5 s and 80°C for 5 s, 52°C for 5 s, 80°C 5 s, and 72°C for 3 min.
A total of 40μL of molecular grade water and ion exchange resin (Sequenom) was added to each sample. Samples were rotated for approximately 4 h and kept in the refrigerator for up to 4 days before spotting. The samples were spotted in duplicates using the RS1000 Nanospotter (Sequenom) and visualized on the MassARRAY® analyzer 4 system (Sequenom) using the autorun settings.
Samples were analysed with Typer Analyzer 4 (Sequenom) and were autoclustered using a signal to noise ratio of 7. Clusterplots were visually inspected, and outliers were further investigated.
All samples were run in duplicates. Genotypes were compared between spots and duplicate typings as described in  and implemented with the statistic software R (R core team, version 2.11.0, URL http://www.R-project.org). The SNPs rs26722, rs28777, rs1426654, rs1800407, rs7495174, rs8059973, rs12203592, rs12913032, rs16891982 and rs36118030 all had minor allele frequencies (MAF)<0.01 and ≤4 observations, and were removed from the analysis.
Sequencing of MC1R
The MC1R gene of all 362 individuals was sequenced. A region encompassing the MC1R exon and the promoter region was amplified in a single PCR amplicon of 1,963bp. Prior to library preparation, we employed a multiplexing approach using endonuclease digestion of the PCR product as previously described . Libraries were prepared for sequencing with the TruSeq® DNA Sample Preparation kit (Illumina) and paired-end sequenced (2x250 cycles) on the Illumina Miseq platform using the Illumina MiSeq Reagent Nano kit v2 (500 cycles).
Illumina adaptors were trimmed using Flexbar . The FASTQ files were aligned to the MC1R reference sequence assembly Feb.2009 GRCh37/hg19 (UCSC Genome Browser) with the Burrows-Wheeler Aligner (BWA) MEM algorithm  to generate BAM files. Variant calling was carried out using GATK ver. 2.6.5 . Variants were accepted if they had a minimum coverage of 50. Variants, where two different alleles were observed, were accepted as heterozygote variant calls if the frequency of the minor variant allele was >0.15. Variants were analysed using Alamut Batch (Interactive Biosoftware, France). MC1R variants were grouped according to potential significance. All missense, non-sense, and frameshift mutations (S2 Table) were assigned to the MC1R variant group and analysed together (Table 2). Due to a low number of participants and a number of unclassified variants detected, the R/r system of MC1R mutation classification  was disregarded.
All statistic calculations were performed using R (R core team, version 3.1.1, URL http://www.R-project.org). The PPF data was log transformed as this gave the best approximation to the normal distribution. All PPF data groups passed the Anderson-Darling test for normality (Fig 3). Correlations between logaritmically transformed PPF measurements of arm and buttock areas were investigated using the Pearson correlation coefficient. Multi linear models were performed using the lm command of R. Models were performed with log10(PPF) as response and gender, age, month of measurement, 22 SNPs with sufficient observations (MAF>0.01), and grouped MC1R variants as explanatory variables (25 variables, 53 comparisons). Logistic regression models were performed using the glm command of R. Models were constructed for age, gender, 22 SNPs and as MC1R to test for association with grouped nevi count or FAMMM (24 variables, 48 comparisons). Welch’s two sample t-test was used due to differences in sample sizes. P-values were corrected for multiple comparisons using Bonferroni correction.
Distributions of arm (A) and buttock (B) measurements in the cohort. Distribution of arm (C) and buttock (D) measurements in the cases. The black line represents a simulated normal distribution with 10,000 observations with the same mean and standard deviation as that of the underlying data.
S1 Table. SNPs, PCR and SBE primers for the iPLEX Gold reactions.
We thank scientific director Thomas F. Hansen, PhD, Institute of Biological Psychiatry, MHC Sct. Hans, Copenhagen Mental Health Services; Department of Clinical Medicine, University of Copenhagen. for initiating contacts and collecting samples.
Conceived and designed the experiments: PJ JDA HU MG CB RG NM. Performed the experiments: PJ JDA LNM MG. Analyzed the data: PJ JDA. Contributed reagents/materials/analysis tools: HU MG RG. Wrote the paper: PJ JDA LNM HU MG CB RG NM.
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domain: literature


text:
From walking to hiking, horseback riding, and even canoeing, kayaking and boating and a wildflower walk…Jessamine County’s trails have something for everyone to do! Check out the list below for a few highlights:
Hiking: Although Camp Nelson Civil War Heritage Park is known more for its museum, Civil War library, and living history events than its walking and hiking trails, it is also an excellent place to get out doors and truly turn history into adventure.
Over five miles of trails with interpretive markers offer beautiful views of the beautiful central Kentucky landscape while learning about the significant role Camp Nelson played in the Civil War. Camp Nelson Heritage, located at 6614 Danville Road (just a few miles south of Nicholasville) is open Tuesday-Saturday from 9 AM-5 PM. Click here to view a trail map. Other hiking trails include: US68 Biking and Walking Trail, Asbury Equine Center trails, Jessamine Creek Gorge, and more.
Riding: Trail Rides at the Equine Center of Palisades Farm offers riders “a relaxing scenic horseback ride through the luscious forested trails overlooking the Kentucky River” on dependable horses. Each trail ride is guided by experienced members of the Equine Center staff.
Enjoy a relaxing scenic horseback ride through luscious forested trails overlooking the Kentucky River. Each trail ride is guided by our experienced staff and steady, dependable horses. Advanced registration is necessary for all rides.
Canoeing/kayaking/boating: Whether you’re in a runabout, a canoe or kayak, you’ll find incredibly beautiful sights, as well as excellent fishing, bird watching, fascinating historical sites, and more along the Kentucky River Blueway Trail–a 42 mile stretch of river that makes up Jessamine County’s southern border running from Valley View to Brooklyn.
There is no actual footpath or trailhead — but a River Guide, Access Points List, and more are available on the Kentucky River Blueway Trail website.
*A handy tip: For facilities such as Camp Nelson Civil War Heritage Park and Asbury Equine Center, check websites and/or call ahead for info regarding holiday/weekend hours.

domain: travel


text:
Hellen Li is helping fuel apple fever in China, and it isn't of the iPhone variety.
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domain: economics


text:
And once again, the loudest reaction is the BAN ALL GUNS NOW OR YOU’RE A MURDERING PSYCHO chant from the left. Sadly, they’re believed, and not by a small percentage of the population. They say that gun control works by saying the states with the strictest gun laws have the lowest violence, which is a bald faced lie. One need only look at Chicago or Detroit to see this, as MI and IL have some of the most restrictive laws in the US regarding owning a firearm, and are in the top (if not AT THE TOP) of the numbers for gun violence.
To put this in context, as UCC was a “gun free zone,” meaning signage to that effect was posted, likely everywhere, would you leave a sign on your door that said “I’m not home and it’s unlocked” and then not expect to be robbed? Of course not. You don’t advertise your weak points, you hide them.
Sadly, when someone who is legally carrying a weapon stops a crime, they are demonized and dragged through the mud in the press as a “gun nut who puts people in danger” or some such idiocy. THIS MUST STOP! We need to stop pandering to the lowest common denominator, to stop letting the idiots be the loudest, and start demanding that the truth be reported.
Yes, it is a tragedy that people died at UCC, and I honestly hope this idiot enjoys his time in hell. Unlike many, I want those who do this and survive their rampage to be put to death in a painful manner. Gilbert and Sullivan said it best, let the punishment fit the crime. You stab someone 87 times, you get stabbed 87 times. You shoot someone, you get shot! I realize that’s not popular, but why are we concerned with the rights of someone who murdered innocent people? Simply put, we’ve been told for decades that “it’s not civilized to sink to their level.” While true, it’s not civilized to sink to their level, it’s not sinking to their level to put to death someone who murdered others. I realize we won’t return to hangings or embrace Gilbert and Sullivan’s suggestion, but we need to remove people like this idiot not only from society, but from the planet’s breathing population.
Finally, what angers me outside of the fact that someone who should have been locked up long ago based on what leads people to do this, is that others are perfectly happy verbally attacking those who would “dare” suggest that, had their been someone who could fight back with force equal to this idiot, lives could have been saved. These are the people who firmly believe a “no guns allowed sign” is the equivalent of Dumbledore casting a spell to prevent any gun from crossing that line, and also the same group seen on the news, utterly confused about “how such a thing could happen here” after a criminal ignores their magical boundary marker. In a country where criminals sue those who they victimize, I wonder what would happen were the families of the victims at UCC to sue the college for ensuring they were as vulnerable as possible?
Well, I’ll tell you this, I won’t stand for it or take it any more. Yes, you’re free to speak your mind, and I’m free to do the same. You spout idiocy at me, I’ll tear down your “logical argument” in a civil manner and leave you crying. You throw insults at me, I’ll ensure those around you know that your parents were either horrible at raising kids, or not there. And above all, you actually dare to attack me physically, I’ll have you on the ground, your right hand scratching the back of your left ear, and my knee on your back in seconds, so make the only shot/punch/kick/whatever count, as I’ll make sure mine all count.
Tweets from Steven Crowder

domain: sociology


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This past Friday (June 19, 2015) marked the one hundred fifty years of celebrating Juneteenth.
On June 19, 1865 the proclamation reached Texas and effectively emancipated the slaves.
Tell me how you celebrate Juneteenth in your hamlet, village, town, city or state.
Tell me if this was your first time celebrating the emancipation of slavery in America.
Tell me, how many people do you know who celebrate Juneteenth that are not African-Americans?


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A Grand Colonial Revival Building
In the heart of downtown Santa Barbara nestled between old mission style homes and colonial office buildings sits what many consider to be the grandest colonial revival structure ever built. The Santa Barbara Courthouse was designed by William Mooser III and completed in 1929 replacing the one damaged by the 1925 earthquake.
The interiors house murals by Sayre Groesbeck and the work of painter John B. Smeraldi who also painted the ceilings inside the Biltmore Hotel in Los Angeles and the iconic Breakers Hotel in Florida.
- The courthouse consists of four buildings occupying 150,000 square feet (14,000 m2).
- The clock tower is 85 feet (26 meters) tall.
- The property is surrounded by palms and trees from 25 countries.
The beautiful red tile roof and white stucco structure was designated a National Historical Landmark for its architecture in 2005. Upon entering the courthouse via its grand archway entrance or its lush gardens, visitors find themselves in the ground floor comprised of; courtrooms, offices and large halls decorated with historical artifacts hanging on its walls and beautiful murals painted within.
Continuing to explore the courthouse will eventually lead to a staircase used to reach the clock tower portion of the property. Before reaching the top, visitors can view a room with murals painted by artists Ed Lister illustrating mankind’s landmarks in ancient timekeeping. Above it sits the bell chamber with the tower housing a weight driven Seth Thomas clock.
Within the courthouse’s sunken gardens and mission style interiors, visitors are free to explore the property and enjoy all it has to offer including; guided tours, picnics and special events. Even thou the courthouse is closed for business on the weekends, the property remains open to the public whereby a brief visit to the information desk can provide suggestions on how to explore the property and enjoy the visit.
The clock tower is called “El Mirador” which mean the lookout in Spanish.
The observation deck located at the top of the tower provides 360 degree panoramic views of the Santa Barbara mountains, city and the Pacific ocean. The Santa Barbara Courthouse with is serene grounds, remarkable architecture and beautiful interiors is an extraordinary attraction definitely worth the visit.
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domain: design


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The allegations against Tim Yeo come just a week after another Conservative MP, the backbencher Patrick Mercer (pictured), was forced to resign the party whip after being caught up in a another set of lobbying claims.
As a result of those claims, the Speaker, John Bercow, reportedly suspended more than 80 House of Commons passes and the government promised to bring forward a bill to introduce a statutory register of political lobbyists.
More top news
More than 50 firefighters were called in the early hours of this morning after a car ploughed through a shop window and burst into flames.
The six-time Olympic gold medallist has been forced to pull out of the Jamaican National Championships after suffering a hamstring tear.
The character's death will send shockwaves through Weatherfield.

domain: politics


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A photo story about The World In Faces and its author Alexander Khimsuhin was published by Enterate.mx of Mexico.
The World In Faces author, Alexander Khimushin, talks about the project in the news of RUSSIA ONE, the second largest TV Network in the country, while visiting Ulan Ude, Buryatia.
A story about The World In Faces photo project and its Author Alexander Khimushin is covered by The Tribune from Pakistan. It gets interests from media all over the world now. Click on the photo to read.

domain: geography


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THANE: The Thane police busted a flesh trade racket being allegedly run at a lodge in the district and arrested six men and rescued four women from there.
Based on a tip-off, the anti-human trafficking cell of the Thane police's crime branch raided the lodge in Kalyan township on Tuesday evening, a police official said in a release issued late last night.
The six nabbed persons included the contractor who used run the lodge, its two managers, cashier, waiter and an agent who was part of the prostitution racket, senior police inspector Ravindra Daundkar said.
The police team also rescued four women, including a Bangladeshi national, from the place, he said. The arrested men were booked under IPC sections 370(2)(3) (trafficking of persons) and 34 (acts done by several persons in furtherance of common intention) and relevant provisions of the Immoral Traffic (Prevention) Act, Daundkar said.
They were produced in a local court which remanded them in police custody till August 19, he said.
The rescued women were sent to a rehabilitation centre in Thane, the police official added.


text: Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Fibro and plaquenil Chloroquine class of drug Ok to stop taking hydroxychloroquine Con que puedo tomar el plaquenil para no engodar The usual starting dose of Plaquenil is 200 mg twice a day or 400 mg once a day, administered orally, in people weighing 80 kg or more. The usual dosage works for most people who take Plaquenil, but it is possible to increase or decrease the dose based on individual needs. It's important to watch for possible side effects and toxicity. Sep 01, 2019 800 mg 620 mg base followed by 6.5 mg/kg 5 mg/kg base, not to exceed 400 mg 310 mg base, at 6 hours, 24 hours and 48 hours after the initial dose. Hydroxychloroquine sulfate filmcoated tablets cannot be divided, therefore they should not be used to treat patients who weigh less than 31 kg. Adults—At first, 400 to 600 milligrams mg taken as a single dose or in two divided doses once a day. Then, 200 to 400 mg taken as a single dose or in two divided doses once a day. Your doctor may adjust your dose if needed. However, dose is usually not more than 600 mg or 6.5 mg per kilogram kg of body weight per day, whichever is lower. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. 400 mg plaquenil at night Plaquenil Oral Uses, Side Effects, Interactions., Hydroxychloroquine Tablets - FDA prescribing information. Chloroquine phosphate dosage Please check your prescription with your doctor. 800 mg seems like an unusually high dose. Never hurts to check and be sure. I take 400 mg in am with breakfast 200 mg X 2. I have no problems, but I also take a probiotic each day. All the best. Can I take Plaquenil at night? - Sarcoidosis - Inspire. Hydroxychloroquine Oral Route Proper Use - Mayo Clinic. When best time of day to take plaquenil? - LUPUS UK. Going from 400 to 200 in plaquenil? My rheumy today suggested I try to go down to 200 mg of plaquenil a day, instead of 400. He said they’ve seen the results to be about the same. Hi all- I've been on Plaquenil 400 mg daily for just about two months now. Shortly after starting I noticed a marked increase in the number of hot flashes/night sweats and anything at any time can irritate the heck out of me. The irritation is more then my normal PMS irritation that only lasted a day or two each month. Apr 12, 2011 I was put on Plaquenil three weeks ago, 400 mg once a day. About a week into it, I started feeling nauseated, lightheaded, dizzy, extremely gassy blush shaky, and had a burning pain in the pit of my stomach. I called my rheumy and she said to stop it for now, wait a bit and then start it again to see what happens.


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Domain registrar and net infrastructure operator VeriSign announced today that it will raise the fees for registering
.net domains by $0.40 beginning October 1, 2008. The fee increases are allowed under Verisign’s agreement with ICANN; under that agreement, Verisign can raise fees for
.com domain registration in four of the six years between 2006 and 2012.
The new fees for registering a .com domain will be $6.86; a .net domain will run $4.23. These fees are components of th overall cost to register a domain; various registrars have different fee structures, but will likely pass along the fee increases directly to domain buyers.
VeriSign says continued increased in Internet traffic, the proliferation of consumer-driven Internet services, and the need to further fortify the TLD’s infrastructure against “increasingly sophisticated cyber attacks” are behind the fee increases. The company says it plans to increase the capacity of its overall Internet infrastructure tenfold by 2010, pushing bandwidth at key operation centers around the world to over 200 Gbps and expanding its DNS capacity from being able to handle 400 billion queries a day to over 4 trillion queries a day.
- The best VPN services for 2021
- The internet’s ‘phonebook’ is flawed and outdated. It’s time for an upgrade
- How to run a free background check
- What is a DNS server? Here’s how the Internet serves up your favorites
- Where to download free stock photos and public domain images


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Support us | Visit us | Contact us
28 January 2011
The Royal Society Enterprise Fund announced this week that it has participated in a £1.6m funding round for Novacem, a company developing carbon negative cement. Novacem’s two other existing investors – Imperial Innovations and the London Technology Fund – also participated in the round. A new investor – Laing O’Rourke – has also joined the group.
The Royal Society Enterprise Fund first invested in Novacem as part of a funding round in August 2009.Novacem is developing a new generation of carbon negative cement systems based on magnesium oxide and offers the cement industry a scalable alternative to current carbon intensive production. The annual production of over 2.5 billion tonnes of Portland cement is already responsible for 5% of man-made global CO2 emissions, and cement volumes are expected to double by 2050.
No carbon emissions are released from the magnesium silicate raw material used, and overall more CO2 is absorbed than emitted during production. Novacem is currently working with a world-class eco-system of partners to accelerate deployment of its technology to market. Novacem videos with more information can be seen at at http://novacem.com/news/videos/ .
Novacem will use the £1.6m raised to continue the development of its carbon negative cement and manufacturing process, and to expand its commercial activities in the run up to a Series-A financing in mid-2011.
Sir Peter Williams FRS, Treasurer of the Royal Society, said:
“Novacem is exactly the type of company the Enterprise Fund was created to support: It is based on outstanding science, has enormous potential commercial opportunities but is nevertheless high-risk. Over the last year we’ve seen it grow in strength and we are very pleased to be able to participate in this next stage of it’s development.”
Novacem Chairman, Stuart Evans, commented:
“Cement is a truly vital strategic commodity but faces enormous challenges in a low carbon world. The addition of Laing O’Rourke to our investor group is exciting as we continue to build the eco-system of industrial partners to deploy our technology across the world. We are also delighted that our original investors have chosen to make follow-on investments. These both endorse the huge potential in the Novacem technology. This new investment makes us very excited about 2011.”
Learn about our mission to expand the frontiers of knowledge.
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Research published in Open Biology today identifies, for the first time, nearly all the genes required for reproduction of a cell in a living organism.
The Government’s spending decisions for the financial year 2015-16 provide an important opportunity to strengthen the role of research and innovation as drivers of UK growth and competitiveness, according to the UK’s four national academies, including the Royal Society.
A paper published in Biology Letters today reveals a new species of ichthyosaur (a dolphin-like marine reptile from the age of dinosaurs) which revolutionises our understanding of their evolution and extinction.
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Even as recently as a couple of years ago, fans considered fantasy sports to be just a hobby while those associated within each real-life version of the sport thought it was a distraction.
But it has since bloomed into an estimated $3.38 billion dollar industry that encompasses products, services, and entry fees, and is embraced by many fans, the NFL, and other sports leagues alike. There are radio stations, TV shows and soon a 24/7 news network dedicated to fantasy news and advice. So the fantasy world is on fire and there’s money to be made, but how?
The fantasy sports gold rush is no different than any other business rush in the past. People see dollar signs and all of a sudden they are in a congested race for the same market share. When I decided to start my own business, JockBrokers.com, a legal alternative to sports gambling, I had to ask myself, “Where do I find my edge?” Instead of attempting to compete for a tiny sliver of the same pie I decided on a unique approach.
Justin Baggott is the founder and chief executive officer of Jockbrokers.com, a fantasy sports startup based out of Carbondale, Illinois, that offers fans a legal alternative to sports gambling. Read the rest of his post at Upstart Business Journal.


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By Suman Thakur
This story is about the life of dog and his sensitivities. His life is full of happiness and enthusiasm. He has emotions like us. The book offers insights into how dog feel about their surroundings. It is about the love and bonding between dog and human being. The story is about an adventurous dream of a very sweet dog named ‘Mogli’.

domain: artistic


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We are a family-owned business, committed to giving you the best service, and selection available. Our customers are our shareholders and we strive to make them happy! Memories are precious and time is important in getting the best overall quality so call us today for an appointment to discuss your keepsake needs.
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Flower Petal Jewelry
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