text:
- William Makepeace Thackeray
William Makepeace Thackeray
William Makepeace Thackeray
Born William Makepeace Thackeray
18 July 1811
Died 24 December 1863 (age 52)
Occupation Novelist Nationality English Period 1829–1864 (published posthumously) Genres Historical Fiction Notable work(s) Vanity Fair Spouse(s) Isabella Gethin Shawe
William Makepeace Thackeray ( //; 18 July 1811 – 24 December 1863) was an English novelist of the 19th century. He was famous for his satirical works, particularly Vanity Fair, a panoramic portrait of English society.
Thackeray, an only child, was born in Calcutta (the capital of the British Indian Empire at the time, in the grounds of what is now the Armenian College & Philanthropic Academy – on the old Freeschool Street, now called Mirza Ghalib Street), India, where his father, Richmond Thackeray (1 September 1781 – 13 September 1815), held the high rank of secretary to the board of revenue in the British East India Company. His mother, Anne Becher (1792–1864) was the second daughter of Harriet and John Harman Becher who was also a secretary (writer) for the East India Company.
William's father died in 1815, which caused his mother to decide to return William to England in 1816 (she remained in India). The ship on which he travelled made a short stopover at St. Helena where the imprisoned Napoleon was pointed out to him. Once in England he was educated at schools in Southampton and Chiswick and then at Charterhouse School, where he was a close friend of John Leech. He disliked Charterhouse, parodying it in his later fiction as "Slaughterhouse." (Nevertheless Thackeray was honoured in the Charterhouse Chapel with a monument after his death.) Illness in his last year there (during which he reportedly grew to his full height of 6' 3") postponed his matriculation at Trinity College, Cambridge, until February 1829. Never too keen on academic studies, he left the University in 1830, though some of his earliest writing appeared in university publications The Snob and The Gownsman.
He travelled for some time on the continent, visiting Paris and Weimar, where he met Goethe. He returned to England and began to study law at the Middle Temple, but soon gave that up. On reaching the age of 21 he came into his inheritance but he squandered much of it on gambling and by funding two unsuccessful newspapers, The National Standard and The Constitutional for which he had hoped to write. He also lost a good part of his fortune in the collapse of two Indian banks. Forced to consider a profession to support himself, he turned first to art, which he studied in Paris, but did not pursue it except in later years as the illustrator of some of his own novels and other writings.
Thackeray's years of semi-idleness ended after he met and, on 20 August 1836, married Isabella Gethin Shawe (1816–1893), second daughter of Matthew Shawe, a colonel, who had died after extraordinary service, primarily in India, and his wife, Isabella Creagh. Their three daughters were Anne Isabella (1837–1919), Jane (died at 8 months) and Harriet Marian (1840–1875). He now began "writing for his life," as he put it, turning to journalism in an effort to support his young family.
He primarily worked for Fraser's Magazine, a sharp-witted and sharp-tongued conservative publication, for which he produced art criticism, short fictional sketches, and two longer fictional works, Catherine and The Luck of Barry Lyndon. From 1837 to 1840 he also reviewed books for The Times. Later, through his connection to the illustrator John Leech, he began writing for the newly created Punch magazine, where he published The Snob Papers, later collected as The Book of Snobs. This work popularised the modern meaning of the word "snob."
Tragedy struck in his personal life as his wife succumbed to depression after the birth of their third child in 1840. Finding he could get no work done at home, he spent more and more time away, until September of that year, when he noticed how grave her condition was. Struck by guilt, he took his ailing wife to Ireland. During the crossing she threw herself from a water-closet into the sea, from which she was rescued. They fled back home after a four-week domestic battle with her mother. From November 1840 to February 1842 she was in and out of professional care, her condition waxing and waning.
In the long run, she deteriorated into a permanent state of detachment from reality, unaware of the world around her. Thackeray desperately sought cures for her, but nothing worked, and she ended up confined in a home near Paris. She remained there until 1893, outliving her husband by thirty years. After his wife's illness, Thackeray became a de facto widower, never establishing another permanent relationship. He did pursue other women, in particular Mrs. Jane Brookfield and Sally Baxter. In 1851 Mr. Brookfield barred Thackeray from further visits to or correspondence with Jane. Baxter, an American twenty years his junior whom he met during a lecture tour in New York City in 1852, married another man in 1855.
In the early 1840s, Thackeray had some success with two travel books, The Paris Sketch Book and The Irish Sketch Book. Later in the decade, he achieved some notoriety with his Snob Papers, but the work that really established his fame was the novel Vanity Fair, which first appeared in serialised instalments beginning in January 1847. Even before Vanity Fair completed its serial run, Thackeray had become a celebrity, sought after by the very lords and ladies he satirised; they hailed him as the equal of Dickens.
He remained "at the top of the tree," as he put it, for the remaining decade and a half of his life, producing several large novels, notably Pendennis, The Newcomes, and The History of Henry Esmond, despite various illnesses, including a near fatal one that struck him in 1849 in the middle of writing Pendennis. He twice visited the United States on lecture tours during this period.
Thackeray also gave lectures in London on the English humourists of the eighteenth century, and on the first four Hanoverian monarchs. The latter series was published in book form as The Four Georges. In Oxford, he stood unsuccessfully as an independent for Parliament. He was narrowly beaten by Cardwell (1070 votes, against 1005 for Thackeray).
In 1860, Thackeray became editor of the newly established Cornhill Magazine, but was never comfortable as an editor, preferring to contribute to the magazine as a columnist, producing his Roundabout Papers for it.
His health worsened during the 1850s and he was plagued by the recurring stricture of the urethra that laid him up for days at a time. He also felt he had lost much of his creative impetus. He worsened matters by over-eating and drinking and avoiding exercise, though he enjoyed horseback riding and kept a horse. He could not break his addiction to spicy peppers, further ruining his digestion. On 23 December 1863, after returning from dining out and before dressing for bed, Thackeray suffered a stroke and was found dead on his bed in the morning. His death at the age of fifty-two was entirely unexpected, and shocked his family, friends, and reading public. An estimated 7000 people attended his funeral at Kensington Gardens. He was buried on 29 December at Kensal Green Cemetery, and a memorial bust sculpted by Marochetti can be found in Westminster Abbey.
Thackeray began as a satirist and parodist, writing papers with a sneaking fondness for roguish upstarts like Becky Sharp in Vanity Fair and the title characters of The Luck of Barry Lyndon and Catherine. In his earliest works, writing under such pseudonyms as Charles James Yellowplush, Michael Angelo Titmarsh and George Savage Fitz-Boodle, he tended towards the savage in his attacks on high society, military prowess, the institution of marriage and hypocrisy.
One of his very earliest works, "Timbuctoo" (1829), contained his burlesque upon the subject set for the Cambridge Chancellor's medal for English verse, (the contest was won by Tennyson with "Timbuctoo"). His writing career really began with a series of satirical sketches now usually known as The Yellowplush Papers, which appeared in Fraser's Magazine beginning in 1837. These were adapted for BBC Radio 4 in 2009, with Adam Buxton playing Charles Yellowplush.
Between May 1839 and February 1840, Fraser's published the work sometimes considered Thackeray's first novel, Catherine, originally intended as a satire of the Newgate school of crime fiction but ending up more as a rollicking picaresque tale in its own right.
In The Luck of Barry Lyndon, a novel serialised in Fraser's in 1844, Thackeray explored the situation of an outsider trying to achieve status in high society, a theme he developed much more successfully in Vanity Fair with the character of Becky Sharp, the artist's daughter who rises nearly to the heights by manipulating the other characters.
He is best known now for Vanity Fair, with its deft skewerings of human foibles and its roguishly attractive heroine. His large novels from the period after this, once described unflatteringly by Henry James as examples of "loose baggy monsters," have faded from view, perhaps because they reflect a mellowing in the author, who became so successful with his satires on society that he seemed to lose his zest for attacking it.
The later works include Pendennis, a sort of bildungsroman depicting the coming of age of Arthur Pendennis, a kind of alter ego of Thackeray's who also features as the narrator of two later novels: The Newcomes and The Adventures of Philip. The Newcomes is noteworthy for its critical portrayal of the "marriage market," while Philip is noteworthy for its semi-autobiographical look back at Thackeray's early life, in which the author partially regains some of his early satirical zest.
Also notable among the later novels is The History of Henry Esmond, in which Thackeray tried to write a novel in the style of the eighteenth century. In fact, the eighteenth century held a great appeal for Thackeray. Not only Esmond but also Barry Lyndon and Catherine are set then, as is the sequel to Esmond, The Virginians, which takes place in America and includes George Washington as a character who nearly kills one of the protagonists in a duel.
Family life and background
Thackeray's father, Richmond, was born at South Mimms and went to India in 1798 at the age of sixteen to assume his duties as writer (secretary) with the East India Company. Richmond fathered a daughter, Sarah Redfield, born in 1804, by Charlotte Sophia Rudd, his native and possibly Eurasian mistress, the mother and daughter being named in his will. Such liaisons were common among gentlemen of the East India Company, and it formed no bar to his later courting and marrying William's mother.
Anne Becher, born 1792, was "one of the reigning beauties of the day," a daughter of John Harmon Becher (Collector of the South 24 Parganas district d. Calcutta, 1800), of an old Bengal civilian family "noted for the tenderness of its women." Anne Becher, her sister Harriet, and widowed mother Harriet had been sent back to India by her authoritarian guardian grandmother, widow Ann Becher, in 1809 on the Earl Howe. Anne's grandmother had told her that the man she loved, Henry Carmichael-Smyth, an ensign of the Bengal Engineers whom she met at an Assembly Ball in Bath, Somerset during 1807, had died, and Henry was told that Anne was no longer interested in him. This was not true. Though Carmichael-Smyth was from a distinguished Scottish military family, Anne's grandmother went to extreme lengths to thwart their marriage; surviving family letters state that she wanted a better match for her granddaughter.
Anne Becher and Richmond Thackeray were married in Calcutta on 13 October 1810. Their only child, William, was subsequently born on 18 July 1811.
Her family's deception was unexpectedly revealed in 1812, when Richmond Thackeray unwittingly invited to dinner the supposedly dead Carmichael-Smyth. After Richmond's death of a fever on 13 September 1815, Anne married Henry Carmichael-Smyth on 13 March 1817, but they did not return to England until 1820, though they had sent William off to school there more than three years before. The separation from his mother had a traumatic effect on the young Thackeray which he discusses in his essay "On Letts's Diary" in The Roundabout Papers.
Reputation and legacy
During the Victorian era, Thackeray was ranked second only to Charles Dickens, but he is now much less read and is known almost exclusively for Vanity Fair. In that novel he was able to satirise whole swaths of humanity while retaining a light touch. It also features his most memorable character, the engagingly roguish Becky Sharp. As a result, unlike Thackeray's other novels, it remains popular with the general reading public; it is a standard fixture in university courses and has been repeatedly adapted for movies and television.
In Thackeray's own day, some commentators, such as Anthony Trollope, ranked his History of Henry Esmond as his greatest work, perhaps because it expressed Victorian values of duty and earnestness, as did some of his other later novels. It is perhaps for this reason that they have not survived as well as Vanity Fair, which satirises those values.
Thackeray saw himself as writing in the realistic tradition and distinguished himself from the exaggerations and sentimentality of Dickens. Some later commentators have accepted this self-evaluation and seen him as a realist, but others note his inclination to use eighteenth-century narrative techniques, such as digressions and talking to the reader, and argue that through them he frequently disrupts the illusion of reality. The school of Henry James, with its emphasis on maintaining that illusion, marked a break with Thackeray's techniques.
His former home in Tunbridge Wells, Kent is now a fine dining restaurant named after the author
List of works
- The Yellowplush Papers (1837) – ISBN 0-8095-9676-8
- Catherine (1839–40) – ISBN 1-4065-0055-0
- A Shabby Genteel Story (1840) – ISBN 1-4101-0509-1
- The Irish Sketchbook (1843) – ISBN 0-86299-754-2
- The Luck of Barry Lyndon (1844), filmed as Barry Lyndon by Stanley Kubrick – ISBN 0-19-283628-5
- Notes of a Journey from Cornhill to Grand Cairo (1846), under the name Mr M.A. Titmarsh.
- The Book of Snobs (1848), which popularised that term- ISBN 0-8095-9672-5
- Vanity Fair (1848) – ISBN 0-14-062085-0
- Pendennis (1848–1850) – ISBN 1-4043-8659-9
- Rebecca and Rowena (1850), a parody sequel of Ivanhoe – ISBN 1-84391-018-7
- The Paris Sketchbook (1840), featuring Roger Bontemps
- Men's Wives (1852) – ISBN 0-14-062085-1
- The History of Henry Esmond (1852) – ISBN 0-14-143916-5
- The Newcomes (1855) – ISBN 0-460-87495-0
- The Rose and the Ring (1855) – ISBN 1-4043-2741-X
- The Virginians (1857–1859) – ISBN 1-4142-3952-1
- The Adventures of Philip (1862) – ISBN 1-4101-0510-5
- Roundabout Papers (1863)
- Denis Duval (1864) – ISBN 1-4191-1561-8
- Sketches and Travels in London
- Stray Papers: Being Stories, Reviews, Verses, and Sketches (1821-1847)
- Literary Essays
- English Humourists
- Four Georges
- Lovel the Widower
- Christmas Books
- Samuel Titmarsh
- The Memoirs of Barry Lyndon Esq
- Irish Sketchbook volume 2
- Character Sketches
- Critical Reviews
- Second Funeral of Napoleon
- Aplin, John. The Inheritance of Genius, A Thackeray Family Biography 1798–1875, The Lutterworth Press (2010), ISBN 978-0-7188-9224-1
- Catalan, Zelma. The Politics of Irony in Thackeray’s Mature Fiction: Vanity Fair, Henry Esmond, The Newcomes. Sofia (Bulgaria), 2010, 250 pр.
- Sheldon Goldfarb Catherine: A Story (The Thackeray Edition). University of Michigan Press, 1999.
- Ferris, Ina. William Makepeace Thackeray. Boston: Twayne, 1983.
- Monsarrat, Ann. An Uneasy Victorian: Thackeray the Man, 1811–1863. London: Cassell, 1980.
- Peters, Catherine. Thackeray’s Universe: Shifting Worlds of Imagination and Reality. New York: Oxford University Press, 1987.
- Prawer, Siegbert S.: Breeches and Metaphysics: Thackeray's German Discourse. Oxford : Legenda, 1997.
- Prawer, Siegbert S.: Israel at Vanity Fair: Jews and Judaism in the Writings of W. M. Thackeray. Leiden : Brill, 1992.
- Prawer, Siegbert S.: W. M. Thackeray's European sketch books : a study of literary and graphic portraiture. P. Lang, 2000.
- Ray, Gordon N. Thackeray: The Uses of Adversity, 1811–1846. New York: McGraw-Hill, 1955.
- Ray, Gordon N. Thackeray: The Age of Wisdom, 1847–1863. New York: McGraw-Hill, 1957.
- Ritchie, H.T. Thackeray and His Daughter. Harper and Brothers, 1924.
- Rodríguez Espinosa, Marcos (1998) Traducción y recepción como procesos de mediación cultural: 'Vanity Fair' en España. Málaga: Servicio de Publicaciones de la Universidad de Málaga.
- Shillingsburg, Peter. William Makepeace Thackeray: A Literary Life. Basingstoke: Palgrave, 2001.
- Williams, Ioan M. Thackeray. London: Evans, 1968.
- ^ Dunton, Larkin (1896). The World and Its People. Silver, Burdett. p. 25.
- ^ Thackeray, William Makepeace in Venn, J. & J. A., Alumni Cantabrigienses, Cambridge University Press, 10 vols, 1922–1958.
- ^ Gary Simons, 'Thackeray's Contributions to the Times, Victorian Periodicals Review, 40:4 (2007, pp. 332–354
- ^ "The Yellowplush Papers". British Comedy Guide. http://www.comedy.org.uk/guide/radio/the_yellowplush_papers/. Retrieved 9 February 2009.
- ^ Menon, Anil (29 March 2006). "William Makepeace Thackeray: The Indian In The Closet". Round Dice. Anil Menon. http://yet.typepad.com/round_dice/2006/03/william_makepea.html. Retrieved 10 February 2009.
- ^ Alexander, Eric (2007). "Ancestry of William Thackeray". Henry Cort Father of the Iron Trade. henrycort.net. http://www.henrycort.net/hrthack.htm. Retrieved 10 February 2009.
- ^ Gilder, Jeannette Leonard; Joseph Benson Gilder (15 May 1897). The Critic: An Illustrated Monthly Review of Literature, Art, and Life (Original from Princeton University, Digitized 18 April 2008 ed.). Good Literature Pub. Co.. pp. 335. http://books.google.com/books?id=MTMZAAAAYAAJ&pg=PT346&lpg=PT346&dq=%22Richmond+Thackeray%22+died.
- ^ Ooty Well Preserved & Flourishing
- ^ Cavendish, Dominic (3 March 2007). "Prime time gentlemen, please". The Daily Telegraph (London). http://www.telegraph.co.uk/culture/theatre/comedy/3663518/Prime-time-gentlemen-please.html.
- The Thackerays in India and Some Calcutta Graves By William Wilson Hunter
- Works available at eBooks @ Adelaide
- Works by William Makepeace Thackeray at Project Gutenberg
- On Charity and Humor, discourse on behalf of a charitable organisation
- Pegasus in Harness: Victorian Publishing and W. M. Thackeray by Peter L. Shillingsburg
- "Bluebeard's Ghost" by W. M. Thackeray (1843)
- PSU's Electronic Classics Series William Makepeace Thackeray site
- "The Adventures of Thackeray on his way through the World: An online exhibition at the Houghton Library
Works by William Makepeace Thackeray
Catherine (1839-40) · A Shabby Genteel Story (1840) · The Luck of Barry Lyndon (1844) · Vanity Fair (1848) · The Book of Snobs (1848) · Pendennis (1848-50) · Men's Wives (1852) · The History of Henry Esmond (1852) · The Newcomes (1855) · The Rose and the Ring (1855) · The Virginians (1857-59) · The Adventures of Philip (1862)
Royal Tunbridge Wells Locations within
Buildings Businesses PeopleList of people from Royal Tunbridge Wells · Disgusted of Tunbridge Wells Political Schools and colleges Sport, leisure and the artsAssembly Hall Theatre · BBC Radio Kent · Dunorlan Park · High Rocks · Ice Melters Curling Club · KMFM West Kent · Linden Park Cricket Club · Nevill Ground · South East Today · Spa Valley Railway · Trinity Theatre · Tunbridge ware · Tunbridge Wells Cricket Week · Tunbridge Wells Football club · Tunbridge Wells Forum · Tunbridge Wells Half Marathon · Tunbridge Wells Rugby club Twin townsItalics denotes places in East Sussex included as they are generally considered part of Tunbridge Wells.
Wikimedia Foundation. 2010.


text:
However, it was the last thing he did before keeling over dead – not from a furious response from the frightened Staffordshire bull terrier, but of a suspected heart attack.
The unnamed man, in his 40s, clashed with the dog's owner at a shop in Cambridge.
The attacker – wearing no shoes and believed to be high on drugs – was restrained by four men after biting the dog.
Moments later, he stumbled into the shop doorway and died.
Police were called and all four men including the dog's owner, aged 40 to 69, all from Cambridge, were arrested on suspicion of manslaughter but have since been released on bail.
The dog's owner, 45, was arrested on suspicion of causing grievous bodily harm but released without further action.
Police confirmed: "There was an altercation outside the shop. We know this involved the man who died and a 45-year-old man.
"The man who died bit the dog belonging to the 45-year-old man, who was arrested on suspicion of grievous bodily harm and has now been released with no further action.
"The deceased then entered the shop. He was restrained because he was behaving destructively.
"The post mortem came back inconclusive so it is still an ongoing investigation."
The dog is reported to be fine after the incident.

domain: law


text:
Discern Report is the fastest growing America First news aggregator in the nation.
- An international survey of 2,002 people found that people who had previously had COVID-19 experienced “significantly increased incidence and severity” of side effects after the COVID-19 vaccine
- Dr. Hooman Noorchashm has repeatedly warned the FDA that “clear and present danger” exists for those who have had COVID-19 and subsequently get vaccinated
- At issue are viral antigens that remain in the body after a person is naturally infected; the immune response reactivated by the COVID-19 vaccine may trigger inflammation in tissues where the viral antigens exist
- The inner lining of blood vessels, the lungs and the brain may be particularly at risk of such inflammation and damage, which could lead to major thromboembolic complications
- Noorchashm believes that people should be screened for SARS-CoV-2 viral proteins prior to COVID-19 vaccination, while vaccination should be delayed for people with symptomatic or asymptomatic COVID-19 infections, as well as those who have recently recovered from the virus
In their race to vaccinate the entire U.S. adult population, health officials are urging everyone to get a COVID shot, regardless of whether or not they’ve already been infected with SARS-CoV-2, the virus that causes COVID-19, and spending billions of dollars in taxpayer funded propaganda to convince people to get the vaccine.
This is an important distinction, however, with at least one scientist warning the U.S. Food and Drug Administration that “clear and present danger” exists for those who have had COVID-19 and subsequently get vaccinated.
That scientist — Dr. Hooman Noorchashm, a cardiac surgeon and patient advocate — warned the FDA that prescreening for SARS-CoV-2 viral proteins may reduce the risk of injuries and deaths following vaccination, as the vaccine may trigger an adverse immune response in those who have already been infected with the virus.1
Unfortunately, health agencies continue to assert that everyone should get vaccinated, even if they’ve already acquired natural immunity via previous infection.
CDC: Get Vaccinated Even if You’ve Had COVID
The U.S. Centers for Disease Control and Prevention admits that it’s rare to get sick again if you’ve already had COVID-19. Despite this, they say those who have recovered from COVID-19 should still get vaccinated:2
“You should be vaccinated regardless of whether you already had COVID-19. That’s because experts do not yet know how long you are protected from getting sick again after recovering from COVID-19. Even if you have already recovered from COVID-19, it is possible — although rare — that you could be infected with the virus that causes COVID-19 again.”
Your immune system is designed to work in response to exposure to an infectious agent. Upon recovery, you’re typically immune to that infectious agent. This is why, for instance, proof of prior diagnosis with chickenpox, measles and mumps is allowed instead of vaccination to enter most U.S. public schools3 — once you’ve had the disease and recovered, you’re immune.
If you’ve had COVID-19, you have some level of immunity against the virus. It’s unknown how long it lasts, just as it’s unknown how long protection from the vaccine lasts. According to the Public Health Agency of Sweden:4
“If you have had COVID-19, you have some protection against reinfection. This means that you are less likely to become infected and seriously ill, and less likely to infect others if you are exposed to the virus again.
Over time, the protection that you get after an infection wanes and there is an increased risk of getting infected again. At present, we estimate that the protection after having had COVID-19 lasts at least six months from the time of infection.”
People With Prior COVID Have More Vaccination Side Effects
An international survey of 2,002 people who had received a first dose of COVID-19 vaccine found that people who had previously had COVID-19 experienced “significantly increased incidence and severity” of side effects after the COVID-19 vaccine.5 Those who had previously had COVID-19 had a greater risk of experiencing any side effect, along with the following, specifically:
The mRNA COVID-19 vaccines were linked to a higher incidence of side effects compared to the viral vector-based COVID-19 vaccines, but the mRNA side effects tended to be milder, local reactions. Systemic reactions, such as anaphylaxis, flu-like illness and breathlessness, were more likely to occur with the viral vector COVID-19 vaccines.
According to the researchers, the findings should prompt health officials to reevaluate their vaccination recommendations for people who’ve had COVID-19:6
Dr. Joseph Mercola said, “Synthetic meat is the epitome of ultraprocessed food, and it seems naïve to think it won’t have health effects similar to other ultraprocessed junk foods.” For All-American REAL beef raised in pastures, sous vide, then freeze-dried for long-term storage, visit Whole Cows and use promo code “no junk” at checkout.
“People with prior COVID-19 exposure were largely excluded from the vaccine trials and, as a result, the safety and reactogenicity of the vaccines in this population have not been previously fully evaluated. For the first time, this study demonstrates a significant association between prior COVID19 infection and a significantly higher incidence and severity of self-reported side effects after vaccination for COVID-19.
Consistently, compared to the first dose of the vaccine, we found an increased incidence and severity of self-reported side effects after the second dose, when recipients had been previously exposed to viral antigen.
In view of the rapidly accumulating data demonstrating that COVID-19 survivors generally have adequate natural immunity for at least 6 months, it may be appropriate to re-evaluate the recommendation for immediate vaccination of this group.”
Surgeon Warns of Immunological Dangers, Blood Clots
Noorchashm has written multiple letters to the FDA, warning them that people should be screened for SARS-CoV-2 viral proteins prior to COVID-19 vaccination. Without such screening, he wrote in one letter to the FDA, “this indiscriminate vaccination is a clear and present danger to a subset of the already infected.”7
He describes the case of 32-year-old Benjamin Goodman of New York, who died within one day of receiving the Johnson & Johnson COVID-19 vaccine. “There will be many more in the coming months as we carelessly and indiscriminately vaccinate the already infected, millions a day … It is a near certainty,” he continued.8 At issue are viral antigens that remain in the body after a person is naturally infected.
The immune response reactivated by the COVID-19 vaccine may trigger inflammation in tissues where the viral antigens are present. The inner lining of blood vessels, the lungs and the brain may be particularly at risk of such inflammation and damage.9 According to Noorchashm:10
“Most pertinently, when viral antigens are present in the vascular endothelium, and especially in elderly and frail with cardiovascular disease, the antigen specific immune response incited by the vaccine is almost certain to do damage to the vascular endothelium.
Such vaccine directed endothelial inflammation is certain to cause blood clot formation with the potential for major thromboembolic complications, at least in a subset of such patients. If a majority of younger more robust patients might tolerate such vascular injury from a vaccine immune response, many elderly and frail patients with cardiovascular disease will not.”
What’s more, Noorchashm quotes one of his previous medical school professors, who said, “the eyes do not see what the mind does not know.” In the case of a vaccine-induced antigen specific immune response, which may trigger thromboembolic complications 10 to 20 days after vaccination, including in those who may already be elderly and frail, the reaction isn’t likely to be registered as a vaccine-related adverse event.
Immediately Delay Vaccination for These Key Groups
In his repeated letters to the FDA, Noorchashm suggests that the FDA “immediately and at the very minimum” delay COVID-19 vaccination for people with symptomatic or asymptomatic COVID-19 infections, as well as those who have recently recovered from the virus.
Because so many cases are asymptomatic, he recommends clinicians “actively screen as many patients with high cardiovascular risk as is reasonably possible, in order to detect the presence of SARS-CoV-2, prior to vaccinating them.”11 As it stands, Noorchashm points out that by ignoring what he believes to be an imminent risk for a sizable minority of people, the FDA’s credibility, and that of the mass vaccination campaign in general, is at grave risk:12
“Can you imagine if the public, without having received any real warning from FDA, becomes aware of an increasing number of such vascular/thromboembolic complications? What do you suppose will happen to the level of ‘vaccine hesitancy’ then?
And, what kind of accountability do you think the public will demand from our experts and federal regulators — especially if they knew, or should have known, that this immunological danger might exist?
The aim of benefiting the majority of our public and saving the nation from this pandemic by quick and aggressive vaccination is an ethically sound one — but where we know of real or likely risks of harm and mortality, we ought to mitigate the risks to those in potential harm’s way.
So doing is the only reasonable, ethical, and likely legal option you can pursue as public health regulators — for in America, we no longer sacrifice the lives of minority subsets of people for the benefit of the majority.”
At least 62 cases of myocarditis, or heart inflammation, in people who received the Pfizer COVID-19 vaccine are being investigated by the Israel Health Ministry. Most of the cases occurred in men under the age of 30 who were in good health, and two deaths have been reported as a result.13,14
No Proof of Efficacy in People Who’ve Had COVID-19
In a high-profile report issued by the CDC’s Advisory Committee on Immunization Practices, 15 scientists stated that the Pfizer-BioNTech COVID-19 vaccine had “consistent high efficacy” of 92% or more among people with evidence of previous SARS-CoV-2 infection.15
But according to Rep. Thomas Massie, R-Ky, “That sentence is wrong. There is no efficacy demonstrated in the Pfizer trial among participants with evidence of previous SARS-CoV-2 infections and actually there’s no proof in the Moderna trial either.”16 In France, the health body la Haute Autorité de Santé (HAS) does not recommend routinely vaccinating those who have already recovered from COVID-19, stating:17
“At this stage, there is no need to systematically vaccinate people who have already developed a symptomatic form of Covid-19 unless they wish to do so following a decision shared with the doctor and within a minimum period of time. 3 months from the onset of symptoms.”
When Massie realized that vaccination didn’t change the risk of infection among people who’ve had COVID-19, he was alarmed and contacted the CDC directly, recording his calls.
“It [the CDC report] says the exact opposite of what the data says. They’re giving people the impression that this vaccine will save your life, or save you from suffering, even if you’ve already had the virus and recovered, which has not been demonstrated in either the Pfizer or the Moderna trial,” Massey says in a “Full Measure” report.18
CDC Allows Misinformation to Continue
Massie spoke with multiple officials on numerous occasions, who acknowledged the misinformation and implied that it would be fixed.19,20 It wasn’t until Massie’s final call with the CDC, to deputy director Dr. Anne Schuchat, that it was acknowledged that a correction was necessary.
“As you note correctly, there is not sufficient analysis to show that in the subset of only the people with prior infection, there’s efficacy. So, you’re correct that that sentence is wrong and that we need to make a correction of it. I apologize for the delay,” Schuchat said. January 29, 2021, the CDC did finally issue a correction, which reads:21
“Consistent high efficacy (≥92%) was observed across age, sex, race, and ethnicity categories and among persons with underlying medical conditions. Efficacy was similarly high in a secondary analysis including participants both with or without evidence of previous SARS-CoV-2 infection.”
Instead of fixing the error, Massie believes the wording just phrases the mistake in a different way and still misleadingly suggests vaccination is effective for those previously infected.22 Meanwhile, increasing numbers of breakthrough COVID-19 cases among the fully vaccinated are being reported, which the CDC has been reporting.
As of April 26, 2021, there have been 9,245 reported cases of COVID-19 in fully vaccinated individuals, including 132 deaths.23 Note this is not total deaths from the vaccine, which is rapidly approaching 4,000.
However, May 14, 2021, the CDC announced it will no longer report breakthrough cases unless they involve hospitalization or death,24 which will obscure the actual number of breakthrough cases occurring, artificially driving down rates and making the vaccines appear to be more effective.
The CDC also changed recommendations on PCR tests for the fully vaccinated, which will further drive down the appearance of breakthrough cases by making them less likely to “test positive.”
PCR tests recommended by the WHO used to be set to 45 cycle thresholds (CTs),25 yet the scientific consensus has long been that anything over 35 CTs renders the test useless,26 as the accuracy will be extremely low, with false positives artificially driving up case numbers.
In April 2021, the CDC recommended the CT be lowered to 28, but only for people who are fully vaccinated.27 Under this guidance, someone with a CT of 30 would not be considered to have COVID-19 if they were fully vaccinated, but if they were not, then their test would be “positive.”
This is beyond obvious that they are rigging the system to create data that fit their fake narrative, which is pushing the entire population to get a vaccine they don’t need, will harm or kill them and which will generate tens of billions of dollars in annual recurring revenue for the drug companies.
In return, the drug companies have no legal risk for any complications, adverse effects or deaths and are given billions of dollars in free advertising from the U.S. taxpayers to get this dangerous gene therapy.
The Big Lie — Natural Infection Isn’t Adequate
Why is it that the media continue to promote the fake narrative that natural immunity — the type acquired by getting infected by and recovering from a virus — isn’t as powerful or long-lasting as vaccine-acquired immunity?28,29 Do you think it might be to support vaccine sales?
Did they forget that COVID-19 vaccines aren’t intended to be a long-term solution, and have NEVER been shown to provide immunity benefits? The original warp speed test only showed reduced symptoms.
Pfizer’s CEO Albert Bourla exacerbated this charade by stating that not only will people need a third booster dose of COVID-19 vaccine within 12 months of being fully vaccinated, but annual vaccination will probably be necessary.30
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Robust natural immunity has been demonstrated, however, for at least eight months after infection in more than 95% of people who have recovered from COVID-19.31,32 A Nature study also demonstrated robust natural immunity in people who recovered from SARS and SARS-CoV-2.33
There continue to be many unanswered questions surrounding COVID-19 vaccines, many of which most of the public has never heard of, such as imprinting and Th2 immunopathology. If you choose to get a COVID-19 vaccine, you’re participating in a giant experiment, acting as a guinea pig to see what will ultimately bear out.
That being said, if you or someone you love have received a COVID-19 vaccine and are experiencing side effects, be sure to report it. Children’s Health Defense (CHD) is calling on all who have suffered a side effect from a COVID-19 vaccine to do three things:34
- If you live in the U.S., file a report on VAERS
- Report the injury on VaxxTracker.com, which is a nongovernmental adverse event tracker (you can file anonymously if you like)
- Report the injury on the CHD website
- 1 Medium February 15, 2021
- 2 U.S. CDC, COVID-19 Vaccination FAQs April 30, 2021
- 3 IDPH, Minimum Immunization Requirements Entering a Child Care Facility or School in Illinois, Fall 2020
- 4 Public Health Agency of Sweden February 3, 2021
- 5 medRxiv March 8, 2021
- 6 PJ Media May 18, 2021
- 7, 8 The Defender March 24, 2021
- 9, 32 The Defender April 5, 2021
- 10, 11, 12 The Defender January 28, 2021
- 13 Health April 26, 2021
- 14 Newsweek April 26, 2021
- 15 MMWR December 18, 2020
- 16 WWMT January 29, 2021
- 17 Nitag Documentation 2021
- 18, 19, 20, 22 Full Measure January 31, 2021
- 21 CDC MMWR Erratum January 29, 2021 / 70(4);144
- 23, 24 CDC, Breakthrough Cases
- 25 WHO.int Diagnostic detection of Wuhan Coronavirus 2019 by real-time RT-PCR, January 13, 2020 (PDF)
- 26 The Vaccine Reaction September 29, 2020
- 27 The Defender May 7, 2021
- 28 MedPage Today May 5, 2021
- 29 Lansing State Journal May 6, 2021
- 30 CNBC April 15, 2021
- 31 Science. 2021 Feb 5;371(6529):eabf4063. doi: 10.1126/science.abf4063. Epub 2021 Jan 6
- 33 Nature July 15, 2020
- 34 The Defender January 25, 2021
‘The Purge’ by Big Tech targets conservatives, including us
Just when we thought the Covid-19 lockdowns were ending and our ability to stay afloat was improving, censorship reared its ugly head.
For the last few months, NOQ Report, Conservative Playbook, and the American Conservative Movement have appealed to our readers for assistance in staying afloat through Covid-19 lockdowns. The downturn in the economy has limited our ability to generate proper ad revenue just as our traffic was skyrocketing. We had our first sustained stretch of three months with over a million visitors in November, December, and January, but February saw a dip.
It wasn’t just the shortened month. We expected that. We also expected the continuation of dropping traffic from “woke” Big Tech companies like Google, Facebook, and Twitter, but it has actually been much worse than anticipated. Our Twitter account was banned. Both of our YouTube accounts were banned. Facebook “fact-checks” everything we post. Spotify canceled us. Medium canceled us. Apple canceled us. Why? Because we believe in the truth prevailing, and that means we will continue to discuss “taboo” topics.
The 2020 presidential election was stolen. You can’t say that on Big Tech platforms without risking cancellation, but we’d rather get cancelled for telling the truth rather than staying around to repeat mainstream media’s lies. They have been covering it up since before the election and they’ve convinced the vast majority of conservative news outlets that they will be harmed if they continue to discuss voter fraud. We refuse to back down. The truth is the truth.
The lies associated with Covid-19 are only slightly more prevalent than the suppression of valid scientific information that runs counter to the prescribed narrative. We should be allowed to ask questions about the vaccines, for example, as there is ample evidence for concern. One does not have to be an “anti-vaxxer” in order to want answers about vaccines that are still considered experimental and that have a track record in a short period of time of having side-effects, including death. One of our stories about the Johnson & Johnson “vaccine” causing blood clots was “fact-checked” and removed one day before the government hit the brakes on it. These questions and news items are not allowed on Big Tech which is just another reason we are getting canceled.
There are more topics that they refuse to allow. In turn, we refuse to stop discussing them. This is why we desperately need your help. The best way NOQ, CP, and ACM readers can help is to donate. Our Giving Fuel page makes it easy to donate one-time or monthly. Alternatively, you can donate through PayPal as well. We are pacing to be short by about $3700 per month in order to maintain operations.
The second way to help is to become a partner. We’ve strongly considered seeking angel investors in the past but because we were paying the bills, it didn’t seem necessary. Now, we’re struggling to pay the bills. We had 5,657,724 sessions on our website from November, 2020, through February, 2021. Our intention is to elevate that to higher levels this year by focusing on a strategy that relies on free speech rather than being beholden to progressive Big Tech companies.
During that four-month stretch, Twitter and Facebook accounted for about 20% of our traffic. We are actively working on operating as if that traffic is zero, replacing it with platforms that operate more freely such as Gab, Parler, and others. While we were never as dependent on Big Tech as most conservative sites, we’d like to be completely free from them. That doesn’t mean we will block them, but we refuse to be beholden to companies that absolutely despise us simply because of our political ideology.
We’re heading in the right direction and we believe we’re ready talk to patriotic investors who want to not only “get in on the action” but more importantly who want to help America hear the truth. Interested investors should contact me directly with the contact button above.
As the world spirals towards radical progressivism, the need for truthful journalism has never been greater. But in these times, we need as many conservative media voices as possible. Please help keep NOQ Report going.
Covid variant BA.5 is spreading. It appears milder but much more contagious and evades natural immunity. Best to boost your immune system with new Z-Dtox and Z-Stack nutraceuticals from our dear friend, the late Dr. Vladimir Zelenko.

domain: medical


text:
Flashback to today last year when we held our Gala Dinner Fundraiser! Due to COVID-19, this fundraiser, as well as many others, have been cancelled this year. We have many ways you can help that won't even cost you anything!
A story of a chronic illness warrior! Sydney, like many others struggles with chronic illness daily.
"My name is Sydney and I am 15 years old from Central New Jersey. I was diagnosed with Postural Orthostatic Tachycardia Syndrome (POTS) in January 2020. At the time, I wasn’t quite sure what that meant, but no one else around me felt the same way I did. I was passing out frequently and had severe head and stomach ache. Being a student athlete, it was difficult to get through most days. I was extremely fatigued most days and my teachers and peers didn’t really understand why, which was so frustrating for me. For the past couple months, I have found other teens who feel the same as me. The best advice I can give to someone who is struggling with POTS is know that you are not alone and your symptoms and pain are real and valid!"
Does volunteer work actually make you happy? "People who volunteer actually experience a boost in their mental health." Helping others is an easy way to help yourself too!
Vacations, parties, school, concerts... Just to name a few of the many engagements you may have had cancelled the past few months. Many have the hope that things will go back to normal soon, but this is what everyday looks like for a chronically ill child. Never take for granted the simple blessings in life!
Special package arrived! This loveable little girl has dreams to be the next Darci Lynne one day. She loves her new ventriloquist puppets and art supplies. River is such a strong girl with hopes and dreams for the future! She is a joy to be around and brings a smile to everyone's face. Stay strong and dream big River!

domain: psychology


text:
I read THE LION, THE WITCH, AND THE WARDROBE under the stairs at my county library when I was a kid, a quiet spot I considered all my own, and I remember turning the pages as fast as I could to get to the end. I read THE HERO AND THE CROWN in the school's library, laying on that hard, tightly woven carpet that might as well be made of stone. I started THE FOREST OF HANDS AND TEETH in the car ride home after attending Carrie Ryan's signing, and I remember walking up the steps of my back porch with my nose still stuck in the book.
There is something magical about the first time you experience a story. Something about discovering the world and its secrets all on your own, about being surprised right there along with the characters, about not knowing if everything ends happily ever after, but hoping it does.
Of all the bars, in all the world, she had to walk into mine.
Play it again, Sam.
This is the start of a beautiful friendship.
After I watched the movie--in my Humanities class in tenth grade--my teacher Ms. Washburn asked me what I thought of it. I said I liked it well enough, but it was full of cliches. "They weren't cliche when the movie was made," Mrs. Washburn said. "The movie did it first."
It made me wish I could have seen Casablanca before it became so popular.
And there's something about experiencing a story for the first time. Personally, I've always sort of wished I could have been there for the original live radio-show production of The Day the Earth Stood Still--I've heard that the reactions of the time--that people believed the Earth was truly under attack by aliens--have been exaggerated by history, but how cool would it be to experience this tale for the first time? To be one of the people sitting by the radio, on the edge of your seat, as you wonder what will happen next?
How about you? What story do you wish you could experience for the first time again?

domain: entertainment


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Boris Johnson has said he is “actively thinking” about a third term, amid criticism of his leadership.
The prime minister was asked if he would like to serve a full second term in office – to 2028 or 2029.
“At the moment I’m thinking actively about the third term and what could happen then, but I will review that when I get to it,” he told reporters.
One Tory MP has said he wants the rules changed so Johnson could face another confidence vote.
Speaking to reporters in Kigali, Rwanda, where he has been at the Commonwealth Heads of Government meeting, the prime minister was asked to elaborate on his comment, replying that he was thinking “about a third term – mid 2030s”.
No 10 later suggested he was joking, but it points to Boris Johnson’s bullish mood despite two bruising by-election defeats in the past week in Wakefield, and Tiverton and Honiton.
Following the results, party co-chairman Oliver Dowden resigned, saying “someone must take responsibility”.
The Lib Dems overturned a huge Tory majority in Tiverton and Honiton – their third by-election victory over Boris Johnson’s party in a year.
And Labour retook the seat of Wakefield, West Yorkshire, which it lost at the 2019 general election.
Former Conservative leader Michael Howard called on Johnson to resign following the by-elections, adding “members of the cabinet should very carefully consider their positions”.
Johnson insisted he would lead his party into the next election, and said he wanted to keep driving forward his plan to reduce inequality across the country – what his government calls “levelling-up”.
While acknowledging it would take time, he added that a “huge amount of progress” could be made in two parliaments.
He told reporters: “Forget about me, think about what this country, the UK could do and where it’s gone.
“We’ve embarked on a massive project to change the government, the constitution of the country and the way we run our legal system, the way we manage borders, our economy, all sorts of things we’re doing differently.
“Also at the same time we are embarked on a colossal project to unite and level up. I happen to believe in that incredibly strongly.
“Levelling-up is a great, great mission and it won’t be easily accomplished and people will say it hasn’t worked, it’s not working yet, people in this constituency aren’t feeling the benefits – it’s going to take time and I want to keep driving it forward.”
But Labour leader Sir Keir Starmer accused the prime minister of “taking voters for granted with impunity”, saying “those days are over”. (BBC)

domain: news


text:
Hepatocellular carcinoma (HCC) is 1 of the most common liver malignant tumor. It is reported to be the fifth most common cancer and the third most common cancer-related cause of death worldwide.[1,2] Due to difficulties in precise diagnosis at an early stage, only 20% of HCC patients could obtain curative treatment through liver transplantation, surgical resection, or ablation treatment. Although some progress has been made in diagnosis and treatment, the 5-year survival rate of HCC in all stages is still lower than 30% due to postoperative recurrence and other reasons. Comprehensive genomic research shows that the role of RNA has attracted widespread attention. Many potential valuable RNAs need to be identified to improve the clinical outcome of HCC patients. However, there are still few specific biomarkers that can be used to show therapeutic effects, and prognostic factors are essential for the treatment of HCC. Therefore, there is a pressing need for molecular screening of HCC biomarkers, to improve prognosis of HCC and reduce the mortality rate.
In humans, more than 85% of the genome is transcribed. Non-coding RNA (ncRNA), which refers to RNA that does not encode a protein, is a new type of transcript that is encoded by the genome. Although not translated, ncRNAs play important roles in various cellular and physiological functions. Non-coding RNAs are divided into 2 groups based on their size. One group is short RNAs with less than 200 nucleotides, such as miRNA, siRNA, snoRNA. The other group is long non-coding RNAs with more than 200 nucleotides. Long non-coding RNAs play a key role in regulating chromatin dynamics, gene expression, growth, differentiation, and development. It is now fully recognized that more than 75% of the human genome is functional and encodes a large number of ncRNAs. Increasing evidence also have indicated that lncRNAs are involved in transcriptional regulation, epigenetic gene regulation, and the pathogenesis of many diseases including cancer.[8,9] Imbalanced lncRNA has been reported to be associated with tumorigenesis and metastasis of HCC. Therefore, constructing a prognostic expression profile of lncRNA in hepatic carcinoma is extremely significant to clarify the mechanism of its development, and further to improve the diagnosis and prognosis.
In this study, RNA sequencing (RNA-seq) data from HCC in the cancer genome atlas (TCGA) was used to explore differences in lncRNA expression profiles between HCC and adjacent livers, and to identify potential genetic biomarkers. Based on the RNA-seq survival analysis, a 9- lncRNAs prognosis model, including TMCC1-AS1, AC008892.1, AL031985.3, L34079.2, U95743.1, KDM4A-AS1, SACS-AS1, AC005534.1, LINC01116 was established. Previous studies had reported that lncRNA TMCC1-AS1 was an independent prognostic factor for patients with HCC.[11,12] LINC01116 is closely related to the occurrence, development and prognosis of many types of cancers such as bladder cancer, ovarian cancer, and osteosarcoma.[5,13,14] Other key lncRNAs have been rarely studied in tumor related researches. The relationship between the lncRNA model and prognosis as well as clinical characteristics of patients with HCC was analyzed. Finally, a predictive nomogram in the TCGA cohort was established and verified internally. Overall, this prognostic model and nomogram might help to predict prognostic of HCC patients.
2.1 Downloading and preprocessing of transcriptome data
RNA-seq count files of liver cancer patients were downloaded from TCGA. The data set is called TCGA-LIHC. Non-cancer and non-cancerous tissue samples were excluded, and finally 412 samples were obtained for subsequent analysis, including 371 patient samples and 50 control samples.
2.2 Extraction and difference analysis of lncRNA
The gdcRNAtools toolkit has been widely used in the construction of ceRNA networks. The count files from TCGA include not only regular mRNA data, but also lncRNA expression data, so lncRNA was extracted by gdcRNAtools in R first, then difference analysis between lncRAN in patients and controls was performed, cutoff value was set as | logFC | > 1 & FDR < 0.05.
2.3 Screening of lncRNAs related to prognosis
Clinical information of corresponding patients were downloaded, samples without overall survival time were excluded, and finally 365 samples were included in this study. First, the samples were randomly divided into training set (N = 184) and test set (N = 181), according to 1:1. Then lncRNAs related to prognosis were identified by 3 criteria.
- (1) lncRNAs with p < 0.01 were screened out by univariate cox analysis.
- (2) Based on robust likelihood-based survival modeling, key lncRNAs were identified by the R language package rbsurv (A forward selection was employed to generate a series of lncRNA models and the optimal model was then selected by using the criterion of minimal AIC (Table 1)).
- (3) Multivariate cox analysis was performed on the screened lncRNAs.
2.4 Construction of lncRNA prognosis model
Finally 9 lncRNAs were identified, and a risk score calculation formula, as follows, was established.
where N is the number of genes, exp was the expression value of gene, and coef was the coefficient of lncRNA in the multi Cox regression analysis.
2.5 Evaluation and verification of model
Survival curve of the test set was calculated using the same formula to verify the robustness of this model, and to further evaluate its stability.
3.1 Differential expression analysis of lncRNA
14,388 lncRNAs were extracted by gdcRNAtools.R package, then difference analysis between lncRNAs in patients and controls was performed, cutoff value was set as | logFC | > 1 & FDR < 0.05. 3116 lncRNAs that differentially expressed were screened out. The volcanic map and heat map were shown in Figure 1.
3.2 Screening of lncRNAs related to prognosis
Clinical information from 371 patients were downloaded, samples without overall survival time were excluded, and 365 samples were included in this study. Then the samples were randomly divided into training set (N = 184) and test set (N = 181), according to 1:1. Firstly, univariate cox analysis was performed on 3116 different lncRNAs, and 290 lncRNAs with P < .01 were screened out (S_Table 1, http://links.lww.com/MD/E286), then the 290 lncRNAs were analyzed using R language package rbsurv based on robust likelihood-based survival modeling, to identify the key lncRNAs. A forward selection was employed to generate a series of lncRNA models and the optimal model was then selected by using the criterion of minimal AIC (Table 1). Finally, 9 lncRNAs (TMCC1-AS1, AC008892.1, AL031985.3, L34079.2, U95743.1, KDM4A-AS1, SACS-AS1, AC005534.1, LINC01116) were screened out as signature lncRNAs which could predict the overall survival rate of HCC.
3.3 Construction of the lncRNA prognosis model
Multivariate cox analysis was performed on the 9 lncRNAs screened out, and the risk model was as follows:
Risk score = (0.082 × expression value of TMCC1-AS1) + (0.20024 × expression value of AC008892.1) + (0.45842 × expression value of AL031985.3) + (0.70212 × expression value of L34079.2) + (0.07987 × expression value of U95743.1) + (0.12007 × expression value of KDM4A-AS1) + (0.08302 × expression value of SACS-AS1) + (0.19776 × expression value of AC005534.1) + (0.2085 × expression value of LINC01116)
We used the surv cutpoint function in the survmier package to determine the best cutoff value, according to the risk score. And patients were divided into 2 categories: the high risk group and the low risk group. The survival analysis based on risk score found that patients with high and low risks could be clearly separated. The ROC curve of 5-year survival rate of the patient was calculated, and the AUC was found to be as high as 0.7454, which proved that this model had strong predictive power. The survival curve and ROC curve were shown in Figure 2, and the specific information of patients in the training set was shown in Figure 3.
3.4 Evaluation of independent prognostic factors
Then gender, age, weight, pathological staging, tumor staging, inflammatory response, and risk score were included in the study. Univariate and multivariate Cox analysis were performed on the training set, and a forest plot was drawn. The results showed that risk score was an independent prognostic factor. At the same time, a nomogram model for the training data set was established, which also showed that risk score had the strongest correlation with survival time, indicating that this risk model based on 9 -lncRNAs signature had a strong predictive power in prognosis of patients with HCC (Fig. 4 A-B) (S_Table 2, Available at: http://links.lww.com/MD/E287).
3.5 Evaluation and validation of the model
Survival curve of the testing set was calculated using the same formula to verify the robustness of this model, and to further evaluate its stability. Results showed that they could be clearly distinguished the patient prognosis. The survival curve and specific information of patients in the testing set were shown in Figure 5. All these results indicated the reliability of our prognostic model, and it was supposed to provide new strategies for treatment.
3.6 Model comparison
The risk model in literature was selected and compared with our 9-lncRNA signature risk model. Based on the corresponding genes in this model, risk score of training set were re-calculated respectively using multivariate Cox analysis, to make the 2 models comparable. ROC of the 2 models were evaluated, and the samples were divided into high-risk group and low-risk group according to the optimal threshold. The prognostic difference in OS between the 2 groups were calculated. The ROC and KM curve of 6-lncRNA signature risk model were shown in Figure 6.
HCC is 1 of the most common malignancies worldwide, causing approximately 700,000 deaths each year. Multiple genetic changes are responsible for the progression of HCC, so exploring the molecular mechanisms of HCC is essential for the diagnosis, treatment, and prognosis of HCC. LncRNA is transcribed by RNA polymerase II/III, showing epigenetic characteristics common to protein-encoding genes, usually spliced by spliceosome and having a poly A tail. Physiologically, lncRNA is involved in many levels of gene expression regulation, from transcriptional and translational regulation to controlling mRNA stability and protein degradation, further affecting cell proliferation, differentiation, and related biological behaviors. In recent years, LncRNA has received increasing attention for its function in human diseases including cancer. Aberrantly expressed lncRNAs can indicate certain stages of cancer progression and can predict early cancer progression or effectively maintain tumor-related signaling pathways. Recent reports from lncRNA suggest that they can be used as novel biomarkers and therapeutic targets.[22,23] Therefore, this study established a prognostic model based on lncRNA in HCC to help improve the diagnosis and predict the prognosis of HCC.
In this study, 3116 differentially expressed lncRNAs in HCC were screened out, and 290 lncRNAs were identified related to the prognosis of HCC by univariate Cox analysis. Then 9 key lncRNAs were identified based on the robust likelihood survival model, and a risk model was established by multivariate Cox analysis. The survival analysis based on risk score showed that patients with high expression had a significantly worse prognosis than the low expression group. The 5-year survival ROC curve showed that the AUC was as high as 0.7454, which proved that this model had a strong predictive power.
Previous studies showed that HCC patients with higher levels of lncRNA TMCC1-AS1 had shorter overall survival (OS) time. Qiu-Jie Zhao et al constructed a 5-lncRNA model significant related to prognosis, based on the lncRNA expression profiles of 370 HCC patients from TCGA, of which TMCC1-AS1 played an important role.[11,12] Chu A found that U95743.1 was closely related to overall survival of gastric cancer patients infected with H. pylori.
Nai qiang Zhu et al constructed a lncRNA-miRNA-mRNA competitive endogenous RNA network through a bioinformatics method, and verified that SACS-AS1 was related to the survival of bladder cancer patients. These results provided a new perspective for researches on lncRNA-related ceRNA network in bladder cancer, thus shedding light on the development of diagnostic biomarkers and therapeutic targets.
Among the 9 lncRNAs screened out, LINC01116 is the most studied at present. Y.N. Fang et al. found that the expression of LINC01116 in epithelial ovarian cancer (EOC) tissues was higher than that in adjacent tissues, and EOC patients with high expression of LINC01116 had significantly worse DFS and OS than patients with low expression. In addition, overexpression of LINC01116 promotes the malignant progression of ovarian cancer by up-regulating Bcl-2 and down-regulating Caspase-3 and Caspase-9 in EOC cells.
B. Zhang et al identified an important lncRNA-miRNA-mRNA pathway involved in LINC01116 in osteosarcoma through bioinformatics analysis, and verified that LINC01116 promoted viability and migration of osteosarcoma cells through IL6R in vitro and in vivo tests.
HB. Hu et al screened the differentially expressed LINC01116 in the public database Gene Expression Omnibus. In vitro and in vivo experiments showed that LINC01116 was highly expressed in breast cancer and related to the overall survival, tumor size, and tumor metastasis (TNM) staging, suggesting that LINC01116 may be a new prognostic biomarker for breast cancer. These previous findings to some extent illustrate the significance of the key lncRNAs in this study in the development of some cancers.
Gender, age, weight, pathological staging, tumor staging, inflammatory response, and risk score were also included in the study. Univariate and multivariate Cox analysis were performed on the training set, and a forest plot was drawn. The results showed that risk score was an independent prognostic factor. A nomogram model for the training set was established, which also showed that risk score had the strongest correlation with survival time. Internal verification of the TCGA cohort showed the same results, indicating that this risk model based on 9 lncRNAs could perform a reliable and satisfactory prediction on prognosis of patients with HCC.
We chose a 6-lncRNA signature risk model developed by Gu JX to be compared with our 9-lncRNA signature, to evaluate the predictability of our model for HCC samples. Risk score of the training set were re-calculated based on the genes in the 6-lncRNA signature risk model, by multivariate Cox analysis. And the ROC of the 2 models were evaluated. Results showed that our 9-lncRNA signature model performed better, the accuracy of the diagnosis based on these 9 lncRNAs was qualified enough to be provided as a solution for molecular diagnosis in HCC.
As far as we know, the biomarkers of these 9 genes have not been studied before and they would provide new ideas for the diagnosis and prognosis of HCC. Pathological staging is a key prognostic determinant for oncologists and HCC patients. However, patient with the same stage of cancer may have different clinical outcomes, indicating that current clinical staging system is not reasonable enough to precisely distinguish the prognosis. The current pathological diagnosis is based entirely on the anatomy of the disease and the staging system, which cannot fully reflect the biological heterogeneity of patients with liver cancer. These problems may affect the prediction accuracy of traditional systems in patients with liver cancer. Our nomograms combine information from different genetic and HCC clinical data to better predict patient outcomes.
In summary, a 9-lncRNA prognostic risk model was innovatively established in HCC, based on data from TCGA in this study. Results showed that the 9-lncRNA prognosis model was a reliable tool for predicting prognosis of HCC, and the nomogram of this prognosis model could help clinicians to choose personalized treatment for HCC patients. However, large-scale prospective studies are still needed to further evaluate the robustness of this model before clinical application, and the underlying biological mechanisms related to this model should be studied in depth as well.
Thank numerous individuals participated in this study
Conceptualization: Benyuan Deng, Zhongwu Liu.
Data curation: Min Yang, Zhongwu Liu.
Formal analysis: Benyuan Deng.
Methodology: Min Yang, Ming Wang.
Project administration: Zhongwu Liu.
Software: Benyuan Deng.
Validation: Ming Wang.
Writing – original draft: Benyuan Deng.
Writing – review and editing: Benyuan Deng, Min Yang, Zhongwu Liu.
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. Gu JX, Zhang X, Miao RC, et al. Six-long non-coding RNA signature
predicts recurrence-free survival in hepatocellular carcinoma
. World J Gastroenterol 2019;25:220–32.
. Jemal A, Bray F, Center MM, et al. Global cancer statistics. CA Cancer J Clin 2011;61:69–90.
. Arzumanyan A, Reis HM, Feitelson MA. Pathogenic mechanisms in HBV- and HCV-associated hepatocellular carcinoma
. Nat Rev Cancer 2013;13:123–35.
. Ozsolak F. Third-generation sequencing techniques and applications to drug discovery. Expert Opin Drug Discov 2012;7:231–43.
. Silva A, Bullock M, Calin G. The clinical relevance of long non-coding RNAs in cancer. Cancers 2015;7:2169–82.
. Tian T, Gong Z, Wang M, et al. Identification of long non-coding RNA signatures in triple-negative breast cancer. Cancer Cell Int 2018;18:103.
. Prensner JR, Chinnaiyan AM. The emergence of lncRNAs in cancer biology. Cancer Discov 2011;1:391–407.
. Braconi C, Patel T. Non-coding RNAs as therapeutic targets in hepatocellular cancer. Curr Cancer Drug Targets 2012;12:1073–80.
. Xu D, Yang F, Yuan JH, et al. Long noncoding RNAs associated with liver regeneration 1 accelerates hepatocyte proliferation during liver regeneration by activating Wnt/beta-catenin signaling. Hepatology 2013;58:739–51.
. Chu A, Liu J, Yuan Y, et al. Comprehensive analysis of. aberrantly expressed ceRNA network in gastric cancer with and without H pylori
infection. J Cancer 2019;10:853–63.
. Zhu N, Hou J, Wu Y, et al. Integrated. analysis of a competing endogenous RNA network reveals key lncRNAs as potential prognostic biomarkers for human bladder cancer. Medicine (Baltimore) 2018;97:e11887.
. Hu HB, Chen Q, Ding SQ. LncRNA
LINC01116 competes with miR-145. for the regulation of ESR1 expression in breast cancer. Eur Rev Med Pharmacol Sci 2018;22:1987–93.


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Robos Prevent Fee Compression (And Don’t Cause It)Advisor Perspectives
Advisor Perspectives welcomes guest contributions. The views presented here do not necessarily represent those of Advisor Perspectives.
Roboadvisors don’t cause fee compression; when used correctly by advisors, they are the solution.
This really was disruption
The word “disruption” is on my list for my next cliché rant. Most companies that claim to be so-called “disruptors” are in fact just early stage adopters of a technology that somebody else thought up.
Betterment (shout out to Jon Stein) broke through with a direct-to-consumer model which was quickly replicated by the Fintech community (most of those firms have been gobbled up by larger financial institutions by now), to which the Schwabs and TD Ameritades of the world said, “not by the hair of my chinny chin chin” and responded by building their own versions.
So where are we in the technology lifecycle of roboadvisors? I’d say we’re still in the early adoption stage. The average person, or even the average private wealth financial institution, hasn’t adopted roboadvisors.
But doesn’t mean they don’t have utility for advisors who want to scale their businesses.
Until recession do us part
Before I go on, let me acknowledge as I’ve said before that roboadvisors haven’t really been tested yet. Those of us who went through 2008 appreciate this view. When the recession hits and robo clients find their portfolios crashing down by 30% and nobody to advise them to resist the urge to sell at the worst possible time, they’ll appreciate the value of human investment advice over staring at red numbers on a computer screen.
By the way, some robos aren’t straight robos anymore. We should start calling them “The Artist Formerly Known as Roboadvisor.” For a higher price, you get access to a team of CFPs available to speak once a quarter or something like that.
I have to wonder if this sounds better than it truly is. You’re telling me someone who doesn’t really have a clue who I am as an emotional being is going to render advice in 20 minutes over the phone that is going to save me and my kids from eating Alpo?
There no way to know until we go through another systematic failure of the banking system. Who’s game?
Tweet me if you’re up for going through that one more time.
Robos have yet to be tested and when the recession does come I envision consolidation. There aren’t going to be dozens of these things that survive in perpetuity –just one or two. For now, no recession in site, robos are still alive, and the industry is scapegoating them for fee compression.
Read the full article here by Sara Grillo, Advisor Perspectives

domain: finance


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At 1,600 meters above sea level, on a sunny plateau between Tyrol and Salzburg, is the alpine village of Königsleiten. Framed by the Kitzbühel Alps to the north and the Hohe Tauern to the south, Königsleiten is located on the southern slope and thus has plenty of sun throughout the winter.
Skiing is done in the romantic village right up to the hotel door, the extensive ski area Zillertal Arena lies at the feet of the piste lovers. But also the family skiing area Wildkogel, the skiing area Kitzbühel or the region Mayrhofen are only 30 minutes away.
Staying in the ski village Königsleiten means guaranteed snow and skiing right in front of the door.
To the slopes of the Zillertal Arena it is only 150 m.
Ski village Königsleiten
For beginners, the so-called "Bürgermeisterlift", a ski meadow with a T-bar lift and the "Märchenwiese", a slope with two T-bar lifts, are close to our hotel. Also the beginner slopes of the ski schools can be reached in 2-5 minutes on foot. The free ski bus takes you to all lifts.
Ski area Zillertal Arena
The 150 km of best prepared slopes and 51 lifts of the "Zillertalarena" provide skiing pleasure for beginners as well as for experienced skiers and snowboarders. Two ski schools, five rental and sports stores complete the offer.
Experience the magic of a cozy dinner on top of the mountain and a subsequent descent over mysterious glittering slopes in the shimmering moonlight.
Good Morning Skiing
The Zillertal Arena makes it possible again this winter. In March, you can take your turn on the pristine slopes in Zell, Gerlos and Königsleiten as early as 6:55 a.m - every Thursday and Sunday!
The downhill run for everyone. Start at the Königsleitenspitze down to the village of Königsleiten.
Off the slopes
Variety is provided. Winterfun while tobogganing, cross- country skiing, winter walking, snowtubing or watching the wildlife.
Cross country skiing
3 trails around Königsleiten
The healthiest way to ski. Whether classic or skating - there are many possibilities in Königsleiten.
in the Hohe Tauern National Park
Snowshoe hikes or on cleared winter hiking trails. A winter wonderland awaits you off the slopes...
at the Hainzenberg
At the Gerlosstein in Hainzenberg, 200 meters of tubing are waiting
Hohe Tauern and Zillertal Alps
Ski touring is popular and always a special experience

domain: geography


Andy Carroll has returned to the West Ham starting line-up for their clash with Chelsea.
The striker has been out of action with a groin problem but comes straight back in for Slaven Bilic's men.
Carroll comes in for Michail Antonio, who is suspended, in the only change from the draw with Watford.
Andre Ayew, who scored off the bench at Vicarage Road, remains on the bench.
Carroll can get his 50th Premier League goal by scoring against the Premier League leaders.
Chelsea meanwhile have stuck with the side that beat Swansea.
That means Cesc Fabregas keeps his place after scoring in that win, with Nemanja Matic on the bench.
He's joined by skipper John Terry and Willian.
West Ham: Randolph, Kouyate, Fonte, Reid, Cresswell, Noble (c), Obiang, Feghouli, Snodgrass, Lanzini, Carroll.
Subs: Adrian, Collins, Masuaku, Byram, Fernandes, Calleri, Ayew
Chelsea: Courtois; Azpilicueta, David Luiz, Cahill (c); Moses, Fabregas, Kante, Alonso; Pedro, Diego Costa, Hazard
Subs: Begovic, Terry, Zouma, Matic, Loftus-Cheek, Willian, Batshuayi


From Home Furnishing Business
High Point Market to Get Funding Boost
The High Point Market stands to get additional funding from the state of North Carolina.
The $21.75 billion budget bill includes an additional $544,528 in marketing funds for High Point Market.
The bill, which has cleared the Senate and House budget committee, is expected to be voted on later this week.
The original budgets from N.C. Gov. Pat McCrory and the State House of Representatives did not include additional marketing dollars for Market. However, Sen. Trudy Wade (R-Guilford) pushed to include it in the budget.
“We are grateful for the dedicated work of Senator Trudy Wade and Representative John Faircloth during these budget talks,” said Doug Bassett, High Point Market Authority chairman and president of Vaughan-Bassett Furniture. “As the largest economic event in the state, High Point Market is committed to positively influencing North Carolina’s economy. This additional funding will be a great resource to help us maintain our status as the largest home furnishings trade show in the world.”
A 2013 Duke University study found that High Point Market generates more than $5.39 billion in economic impact to the overall regional economy. The State House and Senate are expected to vote on the budget bill later this week.
“The additional funds will come from the Commerce Department,” said Tom Conley, president of the High Point Market Authority. “We look forward to using the funds to expand our marketing efforts, with the goal of attracting more attendees to Market.”


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An online community for systems innovation in healthcare
So What’s the Plan?
Health Circle is a platform to support individuals and organizations in learning about systems thinking in healthcare and to use those ideas to collaboratively change health systems towards a more integrated paradigm
Why are we doing it?
It is well known that the way we do healthcare is based upon a reductionist approach, this approach has had many great achievements over the modern era, from curing diseases to the development of the national health systems of today. However this approach has inherent limitations that are becoming ever more apparent as our health systems become more complex and face new challenges. Today, we no longer need a new procedure, drug or policy we need to change the paradigm; the basic set of principles underlying how we understand healthcare and how we organize health systems, what we call systems innovation.
Health systems innovation?
The health systems of today have become hugely complicated, fractured and compartmentalized. We do not have "health systems" we have "health parts" they are integrated within a very narrow spectrum of the full set of factors that are required to develop overall health. What could a holistic approach to health systems design look like ‣ Include all relevant factors ‣ Open and decentralized ‣ Based on value delivered ‣ Networked and user-centered ‣ Process-oriented
Connecting people and building a community through different kinds of events
Learning about Systems Thinking and systems change
Working on real world
projects; design, innovation or consulting
Creating collaborations for systems-level change
We are an open network, here's what the membership role looks like
1-2 people who lead the group and organize activities
Supports the group's
in various ways
Join for events, are listed on the site and kept up to date via newsletter.

domain: design


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Another super fun booth with fun embellishments today! I will be honest, I have seen these Candi products before but just the product in the package did nothing to inspire me! Seeing the Candi booth, by Craftwork Cards (UK) at CHA really has me excited about this product. It was a pure pleasure to speak with Andrew the business development manager, and Julie one of their designers. Both Andrew and Julie were very excited about their product and that is always a joy to watch.
BE SURE TO READ THE ENTIRE POST BECAUSE I HAVE BLOG CANDY AGAIN TODAY
Candi- if you are unfamiliar with it, is a paper product that looks much like a brad, and can be used as an embellishment in much the same way brads can be used. They add that special something to a project, and are really a lot of fun! The great thing is that the price point for customers is much lower than brad and they take up much less storage space. Add that to the fact that the are available in a great variety of colors and you just have to try this product. I'm sharing some photos of their booth so you can see what I mean.
In speaking with the team I learned that they brought all of the contents of this booth over from the UK in just three checked bags! Can you imagine! I love how many uses they had for the Candi product and can't wait to start playing with it more! Now for some closeups of the goodies!!!!
The Craftworks Team was kind enough to give me a few product samples and I thought it would be fun to give one sample 4 oz pack away today. So, here is what you need to do, leave a comment here on my blog telling what creative way you would like to use this product. Then head over to the Craftwork Cards Facebook page! Like their page and leave a message saying that Missie sent you! So simple- not a FB user, send me an email at firstname.lastname@example.org saying you saw it here and I will pass on the message to them!
OH, and don't forget to check out my other CHA posts for more blog candy from Connie Crystal and Jinger Adams!

domain: hobby


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The underrated, unloved liver performs more than 300 vital functions. No wonder the ancients believed it to be the home of the human soul - Natalie Angier
image by: American Liver Foundation
Facing a Silent Liver Disease Epidemic
For most people, the acronym NASH won’t ring any bells. But NASH, or nonalcoholic steatohepatitis, is stealthily showing up in the livers of millions of Americans. Marked by the accumulation of an unhealthy amount of fat and scar tissue in the liver, NASH is quietly reaching epidemic proportions across the globe.
By 2020, NASH is projected to overtake hepatitis C as the leading cause of liver transplants in the U.S. The disease is poised to win that dubious honor because an alarming rise in obesity and type-2 diabetes—key risk factors for NASH—is coinciding with far better treatments for hepatitis C.
Despite NASH’s prevalence, its obscurity isn’t surprising: It doesn’t…
A Big, Fatty Opportunity for Big Pharma
The next big opportunity for pharmaceutical companies is in a disease many people don’t know about. Investors and industry observers should expect to hear a lot about nonalcoholic steatohepatitis, or NASH, in the coming year. Treating this severe form of fatty liver disease is a massive business opportunity, but investors will need patience for promise to develop into profits.
Fatty liver disease: What it is and what to do about it
There are lots of medical terms related to fatty liver disease, and it can get confusing. The main medical umbrella term NAFLD refers to a fatty liver that is not related to alcohol use. NAFLD is further divided into two groups: Non-alcoholic fatty liver (NAFL), otherwise known as simple fatty liver, or Non-alcoholic steatohepatitis (NASH)
Is Fatty Liver Disease the New Diabetes?
Horton says those who are prediabetic or are overweight or obese should especially take notice of this study, given that fatty liver disease is so closely associated with the two.
The Effects of Physical Exercise on Fatty Liver Disease
The increasing prevalence of obesity has made nonalcoholic fatty liver disease (NAFLD) the most common chronic liver disease. As a consequence, NAFLD and especially its inflammatory form nonalcoholic steatohepatitis (NASH) are the fastest increasing etiology of end-stage liver disease and hepatocellular carcinoma.
To Fight Fatty Liver, Avoid Sugary Foods and Drinks
Children with fatty liver disease sharply reduced the amount of fat and inflammation in their livers by cutting soft drinks, fruit juices and foods with added sugars.
Treatment for obesity and fatty liver disease may be in reach
Researchers have discovered 27 new molecules. These molecules all activate a special protein called PPAR-delta and have the potential to treat fatty liver disease, obesity, diabetic nephrotoxicity, and to heal wounds.
Nonalcoholic Fatty Liver Disease & NASH
Usually, nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) cause few or no symptoms. Certain health conditions—including obesity, metabolic syndrome, and type 2 diabetes—make you more likely to develop NAFLD and NASH.
Looming Epidemics: Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steatohepatitis (NASH)
“It is imperative to understand that NAFLD and NASH are conditions that cannot be taken lightly. The damage to the liver is a real medical problem that in many cases can be life threatening. What is even more alarming is that victims of this disease typically do not even know they have it—in fact, it can go undetected for years. Therefore, bringing awareness to the condition within the community is of utmost importance.”
Does My Liver Look Fat in This?
“Non-alcoholic fatty liver disease is currently the most common liver disease in most of the Western world, affecting 30 percent of adults and 10 percent of children — and this number is growing,” warns Tamar Taddei, M.D., associate professor of medicine, section of digestive diseases at the Yale School of Medicine and a member of the American Liver Foundation’s medical advisory committee.
Unchecked, the disease can lead to liver transplant and possible fatality. The good news is that in the vast majority of cases, fatty liver can be managed, or even reversed, through a few simple action steps.
Fatty Liver Disease: More Prevalent in Children
The disease's prevalence is alarming doctors who worry about its progression to nonalcoholic steatohepatitis, or NASH, when the fatty liver becomes inflamed and cells are damaged. That leads to the end stage of cirrhosis, when the liver forms scar tissue and ultimately stops working.
Fatty Liver Is More Dangerous Than You Might Realize. Here’s How to Heal It
What’s so bad about having a fatty liver? Well, among its numerous repercussions include inflammation, which triggers insulin resistance and pre-diabetes, meaning your body deposits fat in your liver and organs including your belly (called visceral fat).
The Invention of an Illness
Fatty liver disease has gone from unknown to pandemic, but does it mean anything?
Threat Grows From Liver Illness Tied to Obesity
Despite major gains in fighting hepatitis C and other chronic liver conditions, public health officials are now faced with a growing epidemic of liver disease that is tightly linked to the obesity crisis.
What's the Big Deal About a Fatty Liver?
For those patients who have been diagnosed with non-alcoholic fatty liver disease, it is the leading cause of chronic liver disease in the United States and other Western countries.
Why fatty liver disease is on the rise
Fatty liver disease was once seen mostly in heavy drinkers. Now, at least a third of adults in Canada have it—and it’s hard to diagnose
Facing a Silent Liver Disease Epidemic
As nonalcoholic steatohepatitis, or NASH, stealthily becomes a leading cause of transplants, drug companies race to develop treatments.
Fatty Liver Diary
Everything about fatty liver, from somebody who managed to reverse NAFLD
The NASH Education Program
The NASH Education Program aims to increase awareness about Non-Alcoholic SteatoHepatitis (NASH). Our mission is to address unmet needs in the field of awareness, via educational initiatives targeting physicians from all relevant medical specialties, as well as patients diagnosed and individuals at risk of developing the disease.
NAFLD is a non-specific title describing several variations of the disease with differing levels of severity. In simple NAFLD, there are no symptoms, only steatosis, which is an excess of triglycerides in the liver.
As research into this spectrum of conditions remains inconclusive, there are no UK guidelines yet developed and uncertainty shrouds many important issues, including prevalence, diagnosis and treatment. Therefore, at this time the priority in management is lifestyle modification and addressing cardiovascular and metabolic risk factors.
©2019 | HealthWorldNet, Inc. | 112162
Last Updated : Tuesday, June 11, 2019


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Bosnian author who kept a diary of her childhood observations of the horrors of the Siege of Sarajevo. Her work, Zlata's Diary, was published in 1993.
She wrote her now-famous diary from 1991-1993, when she was between the ages of ten and thirteen.
After graduating from the University of Oxford, she worked in Dublin as a documentary filmmaker.
During the Bosnian War, she and her family escaped Sarajevo and settled temporarily in Paris, France.
She has been called a Bosnian version of World War II-era Jewish diarist Anne Frank.

domain: history


Here in New England we're thankful for expanding open terrain at ski resorts across Vermont, New Hampshire, and Maine this weekend. Many resorts are sharing social media posts of acreage increasing to 100+ acres, 5-10+ trails, and new snow at their summits from yesterday's storm. Expect sunny skies across much of New England through Saturday with temperatures in the upper 30s and low 40s. Two storms moving through Canada will bring a shot of snow showers to the mountains on Saturday night and again on Sunday night with 1-3" (combined) expected.
Short Term Forecast
Sunshine prevails across New England today on Thanksgiving with many resorts taking advantage of temperatures in the 20s and 30s to expand their terrain with the snow guns. Mother nature turns up the thermostat into the upper 30s and 40s on Friday and Saturday under partly cloudy skies which should make for great (albeit limited) skiing and boarding. Enjoy carving the trails after carving the turkey. Here's a look at Bretton Woods (NH) from this morning from their twitter feed:
We're tracking a couple of clipper-type storms that will bring snow showers to New England on Saturday afternoon into Sunday and again on Monday. Each of these storms will be capable of bringing 0-1" of snow to lower elevations across mountain areas and 1-2" at the summit. The period from Saturday into Monday will come with an increase in wind gusts (20-40 mph; some resorts could have some limited upper-mountain operations if the chairs start swinging) and a drop back in temperatures into 10s and 20s at night and 20s and 30s during the day as we head into the work week -- perfect for maintaining (and artificially expanding) terrain. Both major weather modeling systems (the GFS and ECMWF) suggest a larger (wet) storm tracking up over New York toward the end of next week. Look for this storm to bring warmer weather to the region and a shot at some rain. More on this storm in Saturday and Monday's forecasts.
We're going to take the day off from forecasting tomorrow (Friday) and come back with a fresh forecast on Saturday. Enjoy your Thanksgiving carving turkey or carving some snow.
Did you know that you can get more from OpenSnow?
If you’re looking for a way to support OpenSnow and get access to more data, consider signing up for the All-Access Pass.
- 10-day forecasts
- Custom alerts to know about upcoming powder days
- Time-lapse webcams for tracking exactly when fresh snow has fallen
- Email delivery of the New England Daily Snow as soon as it’s published
All of this costs just $19 for one full year (365 days) and helps to support OpenSnow so that we can spend money and time to further improve our website and mobile apps.
I’d love to count you as an All-Access member!


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Sat, Dec 02|
Depot Holiday Makers Market 2023
Time & Location
Dec 02, 2023, 11:00 AM – 4:00 PM
Cambridge, 6 Broad St, Cambridge, NY 12816, USA
About the event
Holiday Makers Market at the Depot!
Need a last Minuet gift? Not sure what to get for your Mother-in-Law? Company Secret Santa?
Shop local this holiday and find uniquely berautiful crafted gifts from local artisans in the area. From handmade soy candles to home decor to art, there will be something there for every one. Music and Beer will be provided along with a specaltiy Cocktail to enjoy as you shop.
So join us December 2nd from 11am-4pm.

domain: artistic


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If you’ve ever envisioned a world with flying automobiles, your dream may be edging closer to becoming a reality.
According to Chinese state news agency Xinhua, Chinese researchers at Southwest Jiaotong University in Chengdu, Sichuan province, conducted road testing last week for modified passenger cars that use magnets to float 35 millimetres above a conductor rail.
The sedans were modified with strong magnets on the vehicle floors by the researchers, enabling them to float over a conductor rail that was approximately five miles long. According to the report, a total of eight cars were tested, with one test reaching speeds of about 143 miles per hour.
Xinhua reports that government transportation agencies conducted the experiments to research high-speed driving safety precautions. However, according to Deng Zigang, one of the university professors involved in the development of the vehicles, employing magnetic levitation for passenger cars might result in lower energy consumption and greater range.
That would be helpful for the electric vehicle industry’s problems with “range anxiety,” which occur when customers worry they won’t be able to finish a trip in an electric vehicle without running out of juice.
Since the 1980s, some commercial trains have employed magnetic levitation, or “maglev,” which uses an electrified magnetic field to propel or pull objects at high speeds. Today, maglev trains are used in South Korea, China, and Japan. In Qingdao, Shandong province, last year, China unveiled a maglev bullet train with a top speed of 373 miles per hour.
The lack of friction in maglev technology should enable high-speed transport without using as much energy as conventional engine power. Both Richard Branson’s Virgin Hyperloop One and Elon Musk’s The Boring Company have put out the technology for their respective hyperloop ventures. For more than a decade, researchers have been studying the possibility of maglev automobiles, and in 2003, Volkswagen created a concept for a hovering vehicle 2012.
But there are still possible safety hazards that need to be resolved. What would happen, for instance, if a fast car veered off its magnetic track or was struck by a non-magnetic vehicle? There is also the extremely challenging issue of infrastructure: The AutomoBlog points out that in any nation, constructing a statewide system of electromagnetic roadways will probably take years and require a substantial public investment.
It might be worthwhile to overcome the obstacles: According to a 2018 LinkedIn post by George Sassine, a vice president at New York’s State Energy Research and Development Authority, a “era of magnetism” might revolutionise the energy sector and aid in the fight against climate change.
While it may sound like science fiction, he wrote that it “may very well be our regular life in 50 years.”


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Local pastor and activist Danny Givens Jr. has been promoted to serve as the first director of Ramsey County’s Transforming Systems Together initiative. He starts Jan. 25.
Givens had been serving as the director of the county’s Healing Streets Project, a community-centered violence prevention unit within the St. Paul/Ramsey County Public Health Department since February 2019.
“As a Rondo native, I am humbled by the opportunity to work at the intersection of community, systems and innovation in Ramsey County,” Givens said, referring to the historically Black neighborhood in St. Paul largely lost to the construction of Interstate 94. “I am deeply invested in identifying and advancing ideas that will lead to transformational change.”
As the director of TST, he will lead a team of nine that will work to improve county services and programs to ensure that all residents have access and are being served equally. The program has a $5 million budget that creates a formal process through which minority community members meet with county organizational leaders and share in the decision-making process.
Givens, 43, will also lead a team guiding other systems transformation efforts, including the Juvenile Detention Alternatives Initiative (JDAI), adult justice systems reform, and an integrated approach to mental health and justice.
“I’m excited to welcome Danny into this key role that puts systems transformation, power sharing with community and equitable outcomes for every resident at the forefront of our work in Ramsey County,” said County Manager Ryan O’Connor. “Danny’s experience and expertise is ideal for this position. He knows our systems as an employee, but more so has spent years in community working successfully to affect change.”
Givens uses his own personal story to show others a better way to live. When he was 19, he attempted to rob a VFW Post in St. Paul and ended up in a gunfight with Art Blakey, a Ramsey County sheriff’s deputy. Both survived. Givens went to jail and Blakey forgave him and encouraged him to do something good with his life. Givens took the advice to heart.
Prior to coming to Ramsey County, Givens served as clergy liaison at the Affiliation of Black Organizers and the statewide organizer for the Minnesota Unitarian Universalist Social Justice Alliance. Prior to that he was a racial justice fellow at the Kaleo Center for Faith Justice and Social Transformation and a Re-entry Coordinator at Northpoint Health & Wellness Center.
Givens earned a master’s degree from Adler Graduate School and has a bachelor’s degree from Bethel University in Christian ministry.
He has been recognized with a number of awards from organizations including TakeAction Minnesota, OutFront Minnesota and InterFaith in Action of Greater St. Paul. He lives in Minneapolis with his wife and four children.