UK tool and equipment hire company Speedy has opened a new regional service centre in Swindon and is planning to create a number of jobs, the business has announced.
The group, which provides construction supplies and equipment to contractors across the country, is scaling up its operations in the town by relocating to a new base on Kembrey Place, off Kembrey Street.
At 8,500 sq ft, the new depot is double the size of its previous one on Cheney Manor Industrial Estate. Upcoming construction projects could get a potential leg-up from Speedy’s range of hoisting and lifting equipment, which it’s making available from its Swindon centre for the first time.
The group is expecting to recruit for new customer service roles from the local area as a result of its expansion of its services.
The local construction market is poised for activity as plans have been lodged for 8,000 new homes, two high-rise apartment developments, office accommodation and new highway improvements across Swindon.
Dylan Owen, regional director for the South West at Speedy, said: “Our investment in Swindon comes as a number of major schemes edge closer to breaking ground and local contractors are gearing up to develop the local housing, infrastructure and commercial space as the area builds for the future.
“The move represents our commitment to the town and to ensuring businesses can access the right tools, equipment and advice they need to deliver projects safely, on time and on budget.”
Founded in Wigan in 1977, Speedy now operates from more than 200 fixed sites across the UK and Ireland.


text:
Regional Consultation - Africa, July 2016
OHCHR - National Institutions, Regional Mechanisms and Civil Society Section(NRC) ,and Regional Office for East Africa; together with the African Union Commission on Women, Gender and Development Directorate and the AU Department of Citizens and Diaspora Organizations organized a Regional Consultation on Cooperation between UN, African regional and Sub-Regional Mechanisms, civil society and NHRIs on the 8 July 2016,in Kigali , Rwanda.
This was a specific panel discussion held in the context of the African Union (AU) High Level panel on Gender , equality and women’s empowerment (9-10 July 2016), that was opened by Ms. Zuma, the Chairperson of the AU Commission. The HR Adviser in Rwanda, Mr. Chris Mburu, delivered OHCHR opening statement followed by presentations from UN Experts, including the SR on Slavery; regional and sub-regional African human rights mechanisms including: the AU Special Rapporteur on human rights defenders; the ECOWAS Court, The East African Court of Justice ; NHRIs. African Ministers, Members of Parliament; and civil society organizations, also participated in the discussions that focused on key human rights challenges in the region, the situation of human rights defenders in general and in particular women human rights defenders, and enhancing regional and international cooperation in the protection and promotion of human rights.
Women’s rights organizations and NHRIs were encouraged to use the UN and regional mechanisms for the protection of their rights, including by bringing cases and providing amicus briefs to regional courts and mechanisms. Cooperation between all mechanisms in follow up of recommendations addressed to state parties was also a key area of discussion.

domain: law


text:
Raymond Bohlin holds a doctorate in molecular biology. He received his master's degree in population genetics, the study of how adaptation and speciation is expressed by DNA. In other words, he possesses more than a passing knowledge about the theory of evolution. At the University of North Texas, he participated in research revealing that colonies of pocket gophers in Oklahoma and Texas, once indistinguishable, had diverged somewhere along the way into two identifiably... More >>>
Ray Bohlin educated himself about evolution so he could stop public schools from teaching it.

domain: biology


text:
Lat/Long: 23 04.285N/71 11.107W
Distance (24hrs): 103nm
Distance (total): 473nm
Our wind is slowly fading as we move farther north and get closer to the high pressure ridge that is dominating the area N and E of the Bahamas. We ended up motoring for about 7 hours yesterday and still only just made our 100nm minimum goal for the day (120nm is our target). The motion of the boat has become uncomfortable with slightly confused seas and not enough wind to keep our sails full. We're back to motor sailing again this morning and may need to keep this up for most of the day. At least we can set a more direct course now and have to worry less about where the wind is coming from.
The days are starting to blend together. I had to look back over our log to see how many days we had been out. The weather has been so constant and the ocean looks the same each morning and all day that if it weren't for our GPS position updates it would feel like we're not moving at all. Everyone is reading lots to pass the time. I'm now reading the Hobbit to the boys and they seem to be enjoying that.
I managed to get our fishing line tangled around our ruder while trying to clear it of sea weed last night. The lure was on it's last legs after having been attacked by diving birds earlier so I didn't feel to bad about cutting it away. And I didn't really want to have to go for a mid-ocean swim if I didn't really have to.

domain: geography


By Chris Sheppard
PROVIDENCE, R.I. - Several school districts in Rhode Island including Providence, Cranston, South Kingstown, and Coventry have announced closures in preparation for Hurricane Sandy.
The list, maintained by the Rhode Island Broadcasters Association, has grown by several districts since Sunday morning.
You can view the most recent school cancellations and closures here.
Stay with ABC6.com for the latest on Hurricane Sandy.


text:
The club organized an Australia Day 2022 BBQ at Balmoral Beach.
This event was a great success with the Club raising more than $2000 to support the Tonga Tsunami relief program. On the day we also sold another 6 jigsaws to happy customers. It was a successful event raising the image of Rotary and in particular our Club with people asking about who we are, where we meet and our projects.
As we were packing up at the end of the day a very kind gentleman came up and gave us 3 x $100 notes as a “donation” and said “ I’ve watched you guys all day and I know you do great charitable work.” For the team, that was the icing on the cake!. So thanks to the National Australia Day Council for sponsoring the event, to all our members who participated on the day and also to Tania Mace from Lane Cove club who was the organizer for all 5 Rotary clubs in our area taking part in this Australia Day activity.

domain: sociology


text:
Barbecue Sauce Design Tips to Target Your Markets
This entry was posted on April 02, 2014.
Grow Sales by Utilizing Barbecue Sauce Labeling Design Tips
Lightning Labels' barbecue sauce labeling design tips can help brands target the right markets. Barbecue is an American staple, beloved by food professionals, gourmets and backyard grillers alike. If you live in the U.S., chances are you've had barbecue and will again once the weather begins to warm up. This means the consumer base for barbecue sauce is incredibly varied, stretching across states even into international markets, which have their own styles of barbecue. By targeting your barbeque sauce labels to a more specific group, you could see an increase in sales.
Think About Targeted Markets for Barbecue Sauce
There are two main groups to think about for targeted markets for barbecue sauce: gourmet foodies and more casual consumers. Some people just want to purchase a cheap but delicious barbecue sauce to improve the taste of their neighborhood barbecue, a go-to condiment to slather on chicken or ribs. Others are more concerned about flavor profiles, recipes and food pairings. Depending on which group you aim to impress, your label strategy should be somewhat different. Make sure you include information that will appeal to your target market. For foodie types, you can emphasize ingredients, like specific peppers and spices, as well as the best ways to use the sauce.
Overall taste may serve you better for the more casual eaters. Is it tangy, spicy or sweet? Do you have testimonials to highlight? Promote how easy the product is to use in all situations and how it improves the dining experience.
Consider Geography for BBQ Sauce Label Marketing
BBQ sauce label marketing gets your products seen by the right shoppers. Another element to think about for barbecue and hot sauce labels is what style of cuisine your sauce works best with. According to Time Magazine, BBQ sauce differs by region in the U.S. Memphis, Tenn., North Carolina, Kansas City and others all claim to have unique styles. For instance, Memphis is famous for serving up pulled pork that has been soaked in a sweet tomato-based sauce, while western Texans prefer mesquite-smoked brisket. Of course, the U.S. doesn't hold a monopoly on barbecue, either. Many countries have unique styles of this preparation method. From Jamaica to Korea, the barbecue phenomenon is international. Be sure to promote the unique geographical origins of your product, if they exist. Some purists will want to know.
Request your FREE instant quote today.

domain: food


text:
Pfizer Inc. (PFE) Seeks to Cut $1 Billion in Costs; Cuts are in Addition to Those Previously Announced in the Company's R&D Ops
6/8/2011 8:01:14 AM
Pfizer, which has operations in St. Louis, is looking to cut $1 billion in costs, CEO Ian Read told The Wall Street Journal.
About $500 million in annual expenses will be cut this year and another $500 million will be cut next year, sources told the Journal.
"The newest cost-cutting initiative aims to reduce administrative work that is duplicated at Pfizer's headquarters in New York City and in offices around the world," the Journal reports. "Also under review, the people said, are spending for promotion, travel, entertainment and consultants, and sales representatives' spending on printed materials, supplies and electronic gear."
Pfizer's selling, informational and administrative expenses totaled nearly $20 billion last year.
This is the latest in cost cuts the pharmaceutical giant is making in response to its drugs losing their exclusivity. Its $3.8 billion antidepressent, Effexor, went off patent last year, and later this year, blockbuster cholesterol drug Lipitor, which had $10.7 billion in sales last year, will face generic competition.
Pfizer cut about 600 jobs from its once 1,000-member work force in Chesterfield, Mo., as part of the pharmaceutical firm’s larger plan to eliminate more than 19,000 jobs and reduce costs by $5 billion by the end of 2012, following its $68 billion Wyeth acquisition.

domain: finance


text:
Peter Obi, a former governor of Anambra State, Southeast Nigeria has asked the Judicial Panel of Inquiry (JPI) sitting in Awka, the state capital to dismiss a petition by Bonaventure Mokwe, owner of Upper-Class Hotel, Onitsha.
Obi who made the application through his lawyer, Alex Ejesieme (SAN) said the petition was an abuse of court process because there were two pending litigations relating to it before a Court of Appeal.
Ejesieme said the matters were in suit numbers 0/249/2014 and 0/200/2014 represented by Exhibit B2 and B1 respectively where he was claiming damages amounting to about N5 billion, noting that asking for another N120 million was an abuse of process.
He said while Peter Obi and James Nwafor, a Chief Superintendent of Police ( CSP) were defendants in B2, Anambra State Government, Attorney General and Commission for Justice were defendants in B1 both of which Mokwe was the Claimant.
The Senior Counsel who filed a response to Mokwe’s petitions prayed the panel to dismiss the Mokwe’s complaints on four grounds including being sub-judice, panel’s lack of jurisdiction to entertain the matter and being outside the terms of reference of the panel.
He said the panel was set up to investigate police brutality and recommend compensation, stressing that it cannot do much without considering the allegations against his principal who is a private citizen already in court with the petitioner.
According to him, only victims of police brutality who have not pressed for damage in any court should come to the panel.
He said other victims who may have had their cases determined or pending in a competent court of jurisdictions do not have to approach the panel.
Innocent Obi, the legal representative of the police aligned himself with the position of Obi’s counsel.
On his part, Prof. Meshach Umenweke, counsel to Mokwe said the application was misplaced and should not be granted as the applicant or Nwafor were not parties in the petition.
Umenweke said the petition was pressing for compensation from Police and not damages.
He said the panel should entertain it as the outcome would not have effect on Obi arguing that the panel had powers to hear the petition.
The counsel also filed an addendum which was admitted by the panel.
The panel expressed embarrassment over media reports on first hearing that it invited Peter Obi adding that it did not at any time do so.
Hon. Justice Veronica Umeh, Chairman of the panel adjourned to Dec. 10 for ruling on application of Obi.
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text:
Shows a tab for Presets of changes made to the whole picture, and a tab for adjusting sliders to change the whole picture.
The first set of sliders are for quickly tweaking the overall brightness and colors in the image.
Top (Style) Slider – The first slider allows you to apply an overall color, brightness and contrast style to the whole image. The drop down box on the left lets you choose from different color, brightness and contrast styles. For instance, Improver will detect what type of landscape you have and intelligently improve it. Other options let you apply the colors and shades of seasons or art styles, for example
Style Contrast – This slider lets you tweak how much change there is to the brightness and contrast from the style slider without affecting the colors. When it is at 0, only the hue and saturation of the pixels will be changed, when it is at 1 the brightness of the pixels will be changed to the maximum amount specified by the style slider.
Hi/Low Key – When set to 1, it will turn the image into a high key image, with generally bright colors and good contrast. When set to -1 it will turn the image into a low key image with generally dark colors and extreme contrast. At 0 it has no effect.
Auto White Balance – Automatically fix color cast in images.
Auto Levels – Automatically fix color cast and lack of contrast in image.
Flatten Histogram – Recover detail in image highlights, or blacked out shadows.
Exposure Recovery – Fixes over exposed areas.
Exposure – Adjusts the exposure of all the image.
Fill Light – Used to brighten the image, especially in underexposed areas.
Blacks – Darkens the blacks in the area to make the image more punchy.
Vibrance – Increases the intensity of colorful areas while grayer areas are changed less.
Saturation – Increases or decreases the intensity of all the colors in the image.
Colorfulness – Makes an image more colorful by increasing the intensity and range of colors.
Contrast – Adjusts the amount of difference between the light and dark area in the image.
Dehaze – Slide up to remove haze from the image and slider down to add haze. N.B. This slider works on the whole image at once as if the haze was all close up. If you have added labels to the image then there is another Dehaze slider in the Sky section that adds or removes haze from the sky and landscape dependent on depth from the camera to get more realistic results as if the haze were sitting in the landscape.
Manual White Balance
Temperature – Sliding to the right warms the image, making it more red, sliding to the left cools the image making it bluer.
Tint – Adjusts the tint of the image. Sliding to the right makes the image greener, to the left, more magenta.
Reset Section and Save Sliders
At the bottom of each section are the buttons for Reset Section, and Save Preset.
Save a preset for future use by clicking Save Preset. This opens a box to type a preset name. Click OK to save it as a Preset in that section. Click Cancel to exit the Save Preset box.
Click Reset Section to revert all slider values to 0, undoing all of your changes to that section.
Tip: Toggling the power symbol to the right of a section heading lets you turn your changes on and off without permanently undoing them. This is useful if you want to review your edits.
2 thoughts on “v3 Whole Picture”
Hello, Just started with Landscape Pro. Did all my selections. How do you tell it to “go”? I’m sitting here with a masked picture, but no button to see my results?
Hit the ‘Continue’ button.
Comments are closed.

domain: artistic


text:
After a fairly busy Fourth of July night, Fresno, Clovis and Fresno County fire officials on Saturday had one main piece of advice for the public: Be safe when using fireworks.
That also means not using illegal fireworks.
"Clearly, what makes illegal fireworks dangerous ... is their unpredictability," said Don MacAlpine, deputy fire marshal for the Fresno Fire Department. "Once they leave the ground, there's no control over where they're going to come down."
The fire officials said that illegal fireworks are the ones that leave the ground or make extremely loud noises. Fire agencies collected 64 pounds of illegal fireworks Friday night.
The three fire departments received 162 calls Fourth of July night.
"We managed fairly well, but were taxed at certain times," said Tim Henry, a Fresno Fire deputy chief.
At one point, 14 fire units were out on calls, leaving only 10 available units. Clovis Fire Department had fewer calls and backed up other agencies as needed, Henry said.
Of the Friday night fires, the one causing the most damage was to a wood roof that ignited from fireworks in the 6000 block of North Lodi Avenue. Estimated damage was about $75,000, Henry said. Firefighters confiscated both illegal and "safe and sane" fireworks from the residents.
Another firework-related blaze broke out near a rural neighborhood north of Easton where three acres of debris burned, Fresno County fire spokesman Ryan Michaels said. He estimated the damage was about $1,000.
A total of 25 firework citations were issued in fireworks-related incidents. Four were misdemeanor citations, and 11 were administrative. Firework citations typically cost about $1,000, and there is an added $200 fee for fire officials to dispose of fireworks, Henry said.
For fireworks deemed "safe and sane," fire officials said, it is important to use them as they are designed and to always supervise juveniles while the fireworks are lit.
The reporter can be reached at (559) 441-6679 or firstname.lastname@example.org.

domain: news


On Episode 47 of the Metal From The Podcast, we pay tribute to a rock legend, the late Randy Rhoads, as we celebrate his 2021 induction into the Rock And Roll Hall Of Fame. Sydney is joined by two very special guests for this important episode, the sister and brother of Randy, Kathy and Kelle Rhoads. In this conversation spanning over an hour, the pair opens up about growing up with Randy, his beginnings and development as a musician, his time on the road with Ozzy Osbourne, what Randy’s future may have looked like, the act of being the sole preservers of Randy’s long-lasting legacy, and much more.
ANNOUNCING KANE ROBERTS’ “BEGINNING OF THE END” VIDEO: DIRECTOR’S CUT ft. ALICE COOPER and ALISSA WHITE GLUZ!
ANNOUNCING KANE ROBERTS’ "BEGINNING OF THE END” VIDEO: DIRECTOR’S CUT ft. ALICE COOPER and ALISSA WHITE GLUZ! ARMED WITH NEW FOOTAGE, SPECIAL EFFECTS and EDITING TALENT they decided to carve out a new edit for this heavy metal number without time constraints or restrictions. Check out the original BOTE video to see the radical changes that occurred [...]
METAL FROM THE INSIDE PODCAST — EPISODE 28: JOE LYNN TURNER
https://www.facebook.com/joelynnturnerofficial/posts/10158511221808486 On Episode 28 of the Metal From The Inside Podcast, Sydney is joined by the "King Of Dreams" himself, renowned hard rock vocalist Joe Lynn Turner. Most known for his work with Rainbow, Deep Purple, Yngwie Malmsteen, and many others, Joe calls in to chat about everything he's been up to throughout the course [...]
METAL FROM THE INSIDE PODCAST — EPISODE 22: DAMON JOHNSON
https://twitter.com/DamonJOfficial/status/1311311429207764995 On Episode 22 of the Metal From The Inside podcast, Sydney shares her Top 20 Alice Cooper songs as well as some (honorable mentions) in honor of Eddie Trunk’s Top 20 segment on #TrunkNation! Sydney is also joined by legendary guitarist Damon Johnson, known for his time in Alice Cooper as well as Thin [...]
ELLEFSON, FEATURING MEGADETH BASSIST/CO-FOUNDER DAVID ELLEFSON REVEALS FULL TRACKLISTING FOR COVERS LP, ‘NO COVER’!
ELLEFSON the eponymous solo band of Grammy-Winning Megadeth bassist/co-founder David Ellefson has announced the tentative tracklisting for NO COVER, out 10/2 on Combat Records, featuring 17+ cover songs including classic tracks from Motorhead, WASP, Def Leppard, Cheap Trick, Queen, Judas Priest, Twisted Sister, Fastway, Fight, Dead Kennedys, and more, with cover art by Melody Myers (Ellefson, Altitudes and Attitude, Escape The Fate), an homage to [...]
METAL FROM THE INSIDE PODCAST — EPISODE 7: IT’S ALL HAPPENING
On Episode 7 of the Metal From The Inside podcast, Sydney speaks on her background and personal journey in the music industry including her introduction to the hard rock and heavy metal genre, her first meeting with Alice Cooper, the moment she realized she wanted to pursue a career in music, and how absolutely anything [...]
METAL FROM THE INSIDE PODCAST — EPISODE 5: PRIYA PANDA
https://twitter.com/priyapandaxo/status/1218951102479114240 On this week's episode of the podcast, Sydney chats rescheduled tour dates for the summer/fall and your favorite albums that were released on this day in rock history. Joining Sydney on the Metal From The Inside podcast on Episode 5 is Priya Panda, frontwoman of Diemonds (formerly of She Demons) and current solo artist. [...]
THE GUITAR COLLECTIVE / VOLTAGE LOUNGE / NOV 20TH, 2018
When you think of some of the most famous instrumental guitarists out there in the hard rock and heavy metal genre, you think of artists like Yngwie Malmsteen, Joe Satriani, Steve Vai, Jeff Beck, Jason Becker, Marty Friedman, and many more. But added to this list in the past decade are the incomparable players Angel [...]


Measuring the resilience of an urban rail transit network: A multi-dimensional evaluation model
place - asia, place - urban, mode - rail, mode - subway/metro, ridership - behaviour, planning - methods, planning - signage/information
Urban rail transit, Resilience evaluation, Multi-dimensional model, Multi-source data
Once an urban rail transit (URT) system breaks down or is deliberately damaged, it will cause tremendous pressure on the whole urban transportation system. Hence, its ability to deal with incidents has become an important research field. Existing studies seldom consider the entire cycle of an incident and ignore changes in passenger travel behavior during emergency events. In this paper, resilience is defined as the ability of absorbing, resisting and recovering when the URT network fails. We propose a multi-dimensional evaluation model for measuring the resilience by calculating multiple abilities with consideration of multi-source data including passenger flow, train diagram, passenger travel choice behavior, network topology, etc. Finally, we present a case study based on real-world data from the Beijing Subway network to illustrate the effectiveness and applicability of the proposed model. Through the resilience analysis, we recognize the critical stations, measure emergency recovery ability and provide necessary information support for reducing the risk of URT incidents.
Permission to publish the abstract has been given by Elsevier, copyright remains with them.
Ma, Z., Yang, X., Wu, J., Chen, A., Wei, Y., & Gao, Z. (2022). Measuring the resilience of an urban rail transit network: A multi-dimensional evaluation model. Transport Policy, Vol. 129, pp. 38-50.
Transport Policy Home Page:


text:
Top 50 List “Black and White Photos That Inspire”
Many people wake up everyday, not knowing it will be their last. Most live this life without a care in the world. Often times we don’t even think about what happens when we die. It’s not until someone else dies, that we ask ourselves “what will happen to me”,“does this life continue or end once our hearts stop beating”? I always knew deep inside myself there was a God, and I always thought I was “Good Enough” to get into Heaven. I asked Jesus to save me so I could go to heaven to benefit me, I didn’t make Jesus my Lord until 10 years later. “Don’t Wait” to get to know Jesus today. Make Him your Lord & Savior before it’s too late. I could have avoided many “Scars” in life, if I would have aligned myself to His Will for me. Hesitate no longer.
@jboggs222 on Twitter!
The Bible is real history!
What is the Visual Dare?
Every Tuesday midnight (EST) I post a photographic challenge (sometimes called a “VisDare”) that writers may use to help kickstart their work-in-progress, or use as an individual exercise to get the creative juices flowing again. The challenge is to craft a story based on that photo – in 150 words or less.
The photos are carefully selected black-and-white stills, with credit always given to original authorship. (If I can’t credit the author, I don’t use the photo.) I leave the dare up for a week to give ample opportunity for participation. (Posting time is from midnight Tuesday EST to the following Tuesday midnight).
Here are the VisDare rules:
150 words or less.
Post entry in the comments.
Entry is longer than 150 words? Post the link to your blog in the comments.
No erotica or graphic violence, please.
Please limit 2 entries per photo prompt, please.
Don’t forget to read and comment on others’ entries!
That’s it! No judges or rankings. PG rating is maintained in deference to younger or tender-at-heart writers for whom the VisDare is a first step into the wider online writing world. In short: The VisDare is for community, creating, and no-pressure sharing. Make your entries public or not. It’s all up to you.
If you post VisDare entries on your blog, feel free to add the badge at the top of the page (created by the fabulous Amanda McCrina). Link it back to this page (or the specific VisDare you joined), and claim your corner of the VisDare family!!! VisDare

domain: literature


text:
This was uber YUMMY!!! Ross said "this is a new fav of mine". It was a little running because I put more chicken broth then asked for, so stick to that measurement!!! YUMMY :)
2 tsp olive oil
1 pound thin sliced chicken breasts, cut into bite sized pieces
1/2 red onion, chopped
1 red bell pepper, chopped
1 green bell pepper, chopped
1 large zucchini, chopped
1/2 can black beans, drained and rinsed
1/2 cup instant brown rice (uncooked) OR 1/4 cup quinoa, rinsed (uncooked)
1 can fire roasted diced tomatoes, undrained
1/2 cup low sodium chicken broth
1 cup cheddar cheese, shredded
Fresh cilantro, for garnish
1 tsp Dill
1 tsp garlic powder
1 tsp onion powder
1 tsp dried minced onions
1 T parsley
1/4 tsp black pepper
1/2 tsp sea salt
In a 12" skillet, heat oil on medium high. Add chicken, onions and ranch seasoning blend. Saute and stir often for 2 minutes.
Stir in bell peppers, zucchini, beans, tomatoes, rice and chicken broth. Bring to a boil, then cover. Simmer on low for 5 minutes or until chicken is no longer pink in the center and rice is tender.
Sprinkle cheese evenly over skillet, cover and let stand for 5 minutes, until liquid is absorbed. Top with Cilantro and serve!


text:
Rep. Mo Brooks (R-Ala.) blasted CNN when fake news reporter Jim Acosta approached him to ask about January 6.
Walking up to Brooks as he attempted to unlock his bicycle, Acosta was dismissed repeatedly by the congressman, who commented that he did not hold CNN’s reputation in high regard.
“Is there any way we can get you talk about Jan. 6?” Acosta inquired.
“I do not do interviews with CNN because I do not trust CNN to be honorable or truthful,” Rep. Brooks responded.
Brooks continued to slam CNN and deny Acosta as he rode off on his bike.
Acosta recently speculated that political rallies being held by President Donald Trump for Republicans could inspire more Jan. 6-like riots.
“[Pro-Trump Republicans are] living in a different world. They’re in the Q-niverse, I guess you could call it. It’s important to note at the beginning of January 6, some of these same Republicans were blaming it on Antifa. Now they’re blaming it on members of the FBI. You have to wonder who’s next?”
Earlier this month, Rep. Brooks impressively dressed down a reporter who asked if Rep. Marjorie Taylor Greene (R-Ga.) was afraid her “Fire Fauci” Act might anger China.
Rep. Mo Brooks: Congress Was Briefed On ANTIFA Infiltration Of Jan. 6th Stop The Steal Protest


- News Home
- Other categories
Google sued for using the NHS data of 1.6 million Brits 'without their knowledge or consent'
Google is being sued over its use of confidential medical records belonging to 1.6 million individuals in the UK.
Scientists power miniature computer with algae for six months
Scientists have powered a miniature computer for six months using only the electrical current generated by algae.
The Great Translation Movement: 'Despicable' group accused of smearing China's image insists it's exposing online 'echo chamber'
They say they are just volunteers translating posts from the Chinese internet. State media call them "a despicable anti-China smear campaign" and "psychological warfare".
Ukraine war: Social media companies asked to archive evidence of war crimes
US politicians have written to the bosses of Meta, TikTok, Twitter and YouTube to request that the companies archive content that includes potential evidence of Russian war crimes in Ukraine.
Elon Musk says Twitter takeover deal 'temporarily on hold'
Billionaire Elon Musk has said his Twitter deal is "temporarily on hold" over the company's spam and fake user accounts.


Experts seek exemplary actions from govt against graft-wielding crony firms to spur a cultural shift from shady B2B & business-to-govt transactions.
Denmark retained its position as the least corrupt country in 2014 with a score of 92 while North Korea and Somalia shared the last place.
Bedi and Kumar released the book "Bhrashtachar Bharat Choro" (Corruption quit India) at a function in ongoing Patna Book fair at the historic Gandhi Maidan here.
EWS was founded by FIFA in 2005 with the aim to safeguard the integrity of football through prevention and early detection.
Subsidiary will work together with AIFF to tackle the threat to the integrity of football in the region by assisting the AIFF with EWS's services.
The CVC said some of the banks were not following the IAC mechanism and thereby not referring cases or matters to the Commission for its advice.
BJP delegation met Authority Chairman and Chief Executive Officer Rama Raman and demanded the 'Look Out' and CBCID closure report of Yadav Singh.
The march, championed by oppn supporters, is the 5th of its kind in the weeks following Rousseff's October 26 re-election to a second four-year term.
The commission has been obtaining services of DGM-level officers from public sector banks to handle vigilance matters relating to the banking sector.
The order to this effect issued by the Political (Vigilance Cell), Department, Government of Assam comes into force with immediate effect.


text:
Although we have reported on several mGlu4 in vitro and in vivo tool compounds, there still remains room for significant improvement in an acceptable probe for the mGlu4 receptor. To this end, we started from a functional high-throughput screening (HTS) initiated at Vanderbilt University, and discovered an interesting new lead compound, N-(4-(1,1,3,3-tetraoxidobenzo[d][1,3,2]dithiazol-2-yl)phenyl)furan-2-carboxamide, 8 (, Pubchem Compound ID (CID): 4066845; ChemDiv ID: K906-0087). Although compound 8 did not possess favorable calculated properties for a CNS probe compound (MW = 404.4, TPSA = 109.9), it represented a submicromolar starting point for our mGlu4 hit-to-lead program.
The 1,1,3,3-tetraoxidobenzo[d][1,3,2]dithiazol-2-yl)phenyl)carboxamide compounds were synthesized as outlined in . Commercially available mono-Boc protected 1,4-dianiline, 5, was reacted with 1,2-dibenzenedisulfonyl dichloride (Et3N, CH2Cl2) yielding 6. Next, the Boc group was removed under acidic conditions (4.0 M HCl/dioxane) and then the amides, 8a–l, were formed utilizing either the carboxylic acids (EDCI, HOBt, dioxane/DMF) or acid chlorides (DIEA, CH2Cl2).
Synthesis of 1,1,3,3-tetraoxidobenzo[d][1,3,2]dithiazol-2-yl)phenyl)carboxamides, 8a–l.
The structure-activity relationship (SAR) surrounding this set of compounds mirrored other series that we have reported previously ().18, 19, 24
Namely, the 2-pyridyl amide, 8d
, was the most potent heterocyclic substituent (hEC50
= 136 nM). Other aryl, cycloalkyl and 5-membered heterocycles also showed submicromolar potency at both the human and rat mGlu4
receptors. However, despite these modifications, the molecular weight (MW) and polar surface area (TPSA) remained suboptimal for the design of a CNS penetrant probe compound. To confirm this prediction, we profiled 8d
in both in vitro
and in vivo
rat pharmacokinetic (PK) experiments and assessed the extent of CNS penetration for this compound (). While the compound displayed selectivity against other mGlu subtypes (mGlu1–3,5,6–8
), the extent of brain penetration was poor (B/P = 0.085) following intraperitoneal (IP) administration to rats‥
Human mGlu4 potency and %GluMax response (as normalized to standard 1) for selected western amide analogs.
Characteristics of previously reported mGlu4 tool compounds from Vanderbilt University.
Next, we turned our attention to compounds that would have more favorable calculated properties for a CNS penetrant molecule (MW < 400, TPSA < 90) (). To this end we examined the effect of removing the carbonyl of the amide was evaluated. Subsequent replacement of the carbonyl with a methylene group (9b) or a cyclopropyl group (9c) effectively reduced the TPSA (113 to 96) of the scaffold, however with a cost of 10- to 40-fold reduction in mGlu4 potency. Likewise, the addition of a substituent ortho to the amide on the internal phenyl group (9a), or reversing the amide (9d), proved to alter the TPSA but, again, with a significant reduction in the potency for both compounds.
Human mGlu4 potency and efficacy (as normalized to standard 1) for bis-sulfonamide scaffold modifications.
One area of diversification where we have had success with other series is the 4-position of the internal phenyl group. Therefore, we evaluated the activity of a number of substitutions similar to the 1,1,3,3-tetraoxidobenzo[d][1,3,2]dithiazol-2-yl group, in an attempt to reduce TPSA and, ultimately, improve brain penetration. The inclusion of an imide group in lieu of the 1,1,3,3-tetraoxidobenzo[d][1,3,2]dithiazol-2-yl moiety represented a net lowering of the MW by 60 Da and the TPSA by approximately 30 Å2. The synthesis of the imide compounds is shown in .
Scheme 2 Synthesis of N-4-(2,5-dioxopyrrolidin-1-yl)-phenylpicolinamides.’a
Evaluation of the compound containing a sultam group revealed a complete loss of activity (16) (). This core phenyl group does not contain a halogen as do the other compounds; however, the compound containing an internal halogen was not attainable by synthesis. Next, a series of imide compounds were investigated. The initial five-membered imide compound was active (15a, hEC50 = 6200 nM), however the compound lost ~20-fold activity compared to 8d. Potency could be recovered by increasing the bulk of the right-hand side by utilizing phthalimide (and substituted phthalimides) (15b, hEC50 = 59.4 nM; 15c, hEC50 = 42 nM). However, an initial metabolic stability assessment revealed these compounds suffered from extensive oxidative metabolism (results not shown). Having demonstrated the phenyl moiety of the phthalimide as the predominant metabolic soft spot, we turned to saturated versions of the phthalimide (15d – 15l). The initial compound was the direct saturated comparator to 15b (15d, hEC50 = 370 nM). Although there was a ~10-fold loss of potency, 15d still showed <500 nM potency against hmGlu4. The trans-isomer was also evaluated with similar potency to the cis-15d (results not shown). Increasing the bulk of the saturated six-membered ring resulted in interesting compounds. The [2.2.1]-bridged oxo compound (15e, hEC50 = 1300 nM) exhibited a 4-fold loss in potency; however the unsaturated [2.2.1]-bridged carbon analog (15f, hEC50 = 291 nM) and unsaturated [2.2.2]-analog (15g, hEC50 = 287 nM) were more potent than 15d. Reducing the ring size from 6-membered to a substituted 3-membered ring resulted in an equipotent compound (15h, hEC50 = 435 nM). Substitution of the 5-membered imide led to a loss of activity (15i, hEC50 = 1400 nM), but remained comparable to the initial 5-membered imide (15a). However, when the size of the substituent was increased from the gem-dimethyl to cyclohexyl (15j, hEC50 = 158 nM) there was a 10-fold increase in activity. Other bulky substituents were evaluated (15k, hEC50 = 674 nM; 15l, hEC50 = 771 nM); however, these compounds lost activity when compared to 15f.
Human mGlu4 potency and efficacy (as normalized to standard 1) for selected bis-sulfonamide replacements.
With our best compounds evaluated for human potency, we evaluated the in vitro potency of the compounds on the rat mGlu4 receptor. Additionally, we compared compounds in terms of their relative efficacy which we evaluated by assessing the ability of a 30 µM concentration of each compound to shift a glutamate concentration-response curve to the left (represented as fold shift, FS) (). For examination of compound activity at the rat receptor, we employ an assay in which we measure the ability of the Gi/o
receptor to couple to G Protein Inwardly Rectifying Potassium (GIRK) channels.25
In contrast to the calcium mobilization assay, we generally do not observe large increases above the response elicited by saturating concentrations of glutamate alone when GIRK activation is used to assess activity; rather, compounds shift the glutamate concentration-response curve to the left only. Compounds from the 1,1,3,3-tetraoxidobenzo[d][1,3,2]dithiazol-2-yl)phenyl)carboxamide series (8d–8k
) all possessed GluMax values comparable to that of 1
and their efficacies in shifting the glutamate curve were modest, between 3.3 and 7.3. However, moving from the 1,1,3,3-tetraoxidobenzo[d][1,3,2]dithiazol-2-yl)phenyl)carboxamide series to the imide series produced significant divergence in compound efficacies. In particular, two phthalimide compounds (15b
) exhibited large differences in efficacy (leftward fold shift values of 23.6 and 83.0, respectively). Compound 15c
produced the largest leftward shift of the glutamate response curve reported to date. It is also noted that moving away from the phthalimide structures to the saturated imides led to a significant reduction in efficacy and the largest fold shift value for the saturated compounds was 16.7 (15l
), with most of the compounds tested exhibiting fold shifts of <10 (See Supplemental Figure 1
for graphs of human and rat potency and fold shift experiments). The exceptions were 15f
(12.1) and 15l
Rat mGlu4 receptor potency and efficacy (fold shift) data for selected compounds.
Having identified several key compounds based on human and rat potency as well as efficacy at the rat receptor, we evaluated these compounds in a battery of pharmacokinetic assays including an assessment of intrinsic clearance (CLint
) in hepatic microsomes. In addition to intrinsic clearance allowing for the prediction of pertinent rat and human PK parameters (CL and t1/2
), intrinsic clearance assessments allow for a rank ordering of compounds with respect to oxidative lability and a subsequent predicted stability in our in vivo
PK and efficacy models (). Although two compounds based on the phthalimide scaffold (15b
) showed excellent in vitro
potency on mGlu4
, these compounds have been previously reported by Merck and thus were not further evaluated.26
The three compounds based on the saturated imide scaffold (15f, 15j–k
) displayed elevated clearance in human liver microsomes, each exceeding hepatic blood flow in humans (QH
, 21 mL/min/kg). Conversely, an assessment in RLM indicated the compounds to possess moderate-to-high predicted hepatic clearance (CLHEP
), with compound 15k
predicting the best stability in rat (CLHEP
= 30 mL/min/kg). Assessment of the compound’s affinity for plasma proteins was also estimated (percent free, unbound; %fu) in vitro in cryopreserved plasma (). While compounds 15j
were highly protein bound in both human and rat plasma (%fu <1), 15f
displayed lower protein binding under the same conditions (%fu >3). In addition, 15f
was also investigated for nonspecific binding (NSB) in freshly prepared rat brain homogenate employing rapid equilibrium dialysis and found to display a decrease in NSB (%fu >7%) relative to binding to plasma proteins. As a first-tier screen for potential drug-drug interaction liability, the compounds were evaluated for their inhibition of the cytochrome P450 (CYP450 or CYP) enzymes utilizing a cocktail approach in human liver microsomes designed to inform on the inhibition of the five major drug-metabolizing and/or polymorphic CYPs (CYP2C9, 2D6, 3A4, 2C19, and 1A2). All compounds tested showed no significant activity against CYP2D6 and CYP3A4 (>30 µM); and only 15k
showed moderate inhibition of 2C9, 2C19 and 1A2 (8.7 µM, 17.6 µM, and 8.9 µM, respectively).
Predicted hepatic clearance, plasma protein binding, CYP450 inhibition, and mGlu selectivity values for selected compounds
Lastly, these compounds were evaluated for their selectivity against the other mGlu receptors. For initial studies, a 10 µM concentration of compound was applied prior to a complete agonist concentration-response curve (CRC) appropriate for each receptor. This technique allows for the detection of potentiator (leftward shift) or antagonist (rightward shift and/or decrease in the maximal response) activity within a single experiment. Using this assay, all compounds were selective versus the Group II mGlus (2 and 3) and only 15f showed weak PAM activity against a group I receptor (mGlu5, 2.1 FS). However, these compounds did show varying selectivity against the other Group III receptors. Whereas 15j only showed weak activity against mGlu6 (PAM, 2.1 leftward FS of the agonist CRC), 15f was weakly active against both mGlu6 (PAM, 3.1 FS) and mGlu7 (PAM, 2.9 FS), and 15k showed activity against all 3 receptors (mGlu6, PAM, 5.8 FS; mGlu7, mixed agonist/PAM (Ago-PAM) activity, 12.9 FS; mGlu8, PAM, 2.1 FS); the allosteric agonist activity against mGlu7 was equivalent to that observed for mGlu4 (12.9 FS vs. 12.1 FS).
The predicted in vitro ADME properties of these compounds were consistent with advancement for in vivo studies. Thus, the hydrochlorides of these compounds (15f, 15j, 15k) were synthesized and dosed intraveneously (1 mg/kg) and orally (10 mg/kg) to determine pertinent PK parameters such as clearance (CL), volume-of-distribution at steady state (Vss), half-life (t1/2) as well as bioavailability (%F) (). Although all three compounds displayed modest stability (CLHEP) when assessed in rat liver microsomes; 15k proved to be a lower clearance compound in vivo (5.4 mL/min/kg). Both 15f and 15j demonstrated moderate clearance values (37 mL/min/kg and 48 mL/min/kg, respectively), values that correlated well with their in vitro CLHEP values. Due to the exceptional stability of 15k following parenteral administration to the rat, we evaluated this compound in both beagle dog and rhesus monkey employing an IV cassette dosing paradigm. Compound 15k showed excellent stability in both dogs (CL, 7 mL/min/kg) and monkeys (3 mL/min/kg) with each species diplaying a t1/2 of ≥ 3 hrs. Although 15k showed superior stability comparatively, it unfortunately displayed an oral bioavailability less than 10%; Conversely, compound 15f demonstrated an excellent oral bioavailability of 97% whereas 15j displayed a modest bioavailability of 25%.
Rat in vivo pharmacokinetic values for selected compounds
The combination of enhanced bioavailability, oral PK, in addition to an exceptionally low protein binding value, indicated that compound 15f possessed the characteristics to be a potential tool compound which could be evaluated for brain exposure after oral dosing (). The hydrochloride salt of 15f was dosed orally in a microsuspension (10% Tween-80 in 0.5% methylcellulose) and plasma (systemic and hepatic portal) and brain samples were collected for bioanalysis of parent compound up to 6 hours following administration of the compound. The compound showed similar levels in the systemic and HPV plasma, indicating neglible hepatic first pass metabolism (AUCSYS/AUCHPV = 1.01). Compound 15f also displayed exceptional CNS penetration, with compound exposures reaching 800 nM*h (AUC0–6) and a corresponding brain:plasma ratio that reached unity (0.93).
PO pharmacokinetic parameters of 15f, (10 mg/kg, 10% Tween 80 in 0.5% methylcellulose).
Considering the promising PK results for 15f
, we evaluated the compound for selectivity against the other mGlu subtypes. In these studies, a 10 point concentration-response of 15f
was applied prior to an EC20
concentration of agonist appropriate for each receptor. As with our original fold shift-type studies, 15f
was shown to be inactive against mGlu 1, 2, 3, and 8 and was active against mGlu5
= 1.7±0.8 µM, 64.3±0.8% GluMax), mGlu6
>10 µM, 45.8±3.0% GluMax) and mGlu7
(PAM, 2.9±0.7 µM, 64.0±1.4% GluMax) (See Supplemental Table 1
). In addition, 15f
was tested in Ricerca’s Lead Profiling Screen (binding assay panel of 68 GPCRs, ion channels and transporters screened at 10 µM), and was found to not significantly with all the 68 assays conducted (no inhibition of radioligand binding > 50% at 10 µM).
Based on the previous PK studies, 15f
was chosen as a potential tool compound for an in vivo
proof-of-concept study and was examined in a rat model of neuroleptic-induced catalepsy. Here we evaluated the ability of 15f
to reverse haloperidol-induced catalepsy, a preclinical rodent model of motor impairments associated with Parkinson’s disease. The D2
receptor antagonist haloperidol induced robust catalepsy (). As shown in , 15f
(0.1 – 56.6 mg/kg, p.o.) produced a reversal of haloperidol-induced catalepsy (F(8,89)
= 5.8697, p<0.0001), significant at doses of 0.1 – 56.6 mg/kg, as compared with the vehicle control. The effects of 15f
were equally efficacious to those observed using an adenosine A2A
antagonist from Neurocrine Bioscience (compound 23
as a positive control, administered at a dose of 56.6 mg/kg, po.
Figure 10 Reversal of haloperidol-induced catalepsy in rats by compounds 15f after oral dosing. Catalepsy was measured in haloperidol treated (0.75 mg/kg) rats after oral administration of compound (0.1, 0.3, 1, 3, 10, 30 and 56.6 mg/kg) after 30 mins. An adenosine (more ...)

domain: medical


text:
E-commerce firm Coupang reduced its profit loss thanks to record sales during the first quarter of this year. Photo courtesy of Coupang
SEOUL, May 13 (UPI) -- South Korean e-commerce giant Coupang announced it had narrowed a loss in the first quarter of this year, thanks to record sales.
The Seoul-based company, which went public in the United States last year, said Thursday its first-quarter revenue amounted to $5.1 billion, up 22% from a year ago, to net $209 million of a loss, down 29%.
In particular, Coupang saw fast growth in its new businesses, including Coupang Eats, a food delivery system, and Coupang Play, a video streaming service.
The company's global sales stood at $181 million during the January-March period, up 65% from a year before.
"Powered by our unmatched customer experience and services, we continued to grow in the overall e-commerce segment with 32% year-on- year constant currency revenue growth," Coupang CFO Gaurav Anand said in a statement.
"We also recorded the highest gross profit and gross profit margin in the company's history, which in turn helped our product commerce segment to achieve profitability in Q1," he said.
Observers say Coupang should be able to turn a profit in the near future. Founded in 2010 by Harvard MBA dropout Kim Bom-suk, the corporation has lost billions of dollars.
"Coupang has reduced its loss over the past few years. It is expected to turn to a profit later this year or early next year," HMC Investment & Securities analyst Kim Hyun-yong told UPI News Korea.
Coupang's stock price finished at $11.46 Thursday on the New York Stock Exchange. Its initial public offering price was $35.


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domain: design


text:
Activists walk out of rezoning meeting on Central PLA dock
Boycott of public discussions on planned facility in Central comes after Civic Party lawmaker is allowed only 10 minutes to speak
The first round of discussions on plans for a military dock on the Central waterfront ended in a walkout on Monday by activists complaining of "procedural violence" and "rape of public opinion".
The boycott of the Town Planning Board meeting came after Civic Party lawmaker Dr Kenneth Chan Ka-lok’s address ended abruptly when his microphone was turned off to enforce a 10-minute time limit for speakers.
The limit was set as the board faced the longest series of discussions in its history on whether the government should hand over rights for a 0.3 hectare strip of public land to the People’s Liberation Army for military use.
A dozen public meetings have been scheduled over the next two months for the hearings.
But Chan said: "These restrictions are utterly irresponsible and unreasonable.… They are an insult to the public’s intelligence and a rape of public opinion."
Describing the cutting off of his speech as “procedural violence” he said he might take legal action.
Winston Chu ka-sun, former chairman of the Society for Protection of the Harbour, said the board had no legal grounds for setting an arbitrary time-limit.
"Entitlement to a fair hearing is a constitutional right and as a quasi-judicial body [the board] must act reasonably and provide a fair hearing," Chu said.
Chu, a lawyer, former TPB member and long-time harbour-protection activist, said he had a stack of paperwork two metres high prepared for the hearings and it would be impossible to make his case in 10 minutes.
But board chairman Thomas Chow Tat-ming, who is also permanent secretary for development, said the board had received a record 19,000 written submissions since the public consultation began in February, and it had to use the “special arrangements” out of fairness to all.
Chow said he had informed all 2,000 scheduled speakers of the time limit a week ago.
Activists have been fighting the rezoning plan since it was quietly announced in February.
"Why should taxpayer money be used to build such a beautiful harbourfront only to have a military base in the middle of it?" Chan asked during the hearing.
"It’s not a question of ideology or whether or not we trust the PLA – anyway, we’ve all seen what happened on June 4, 1989 – this is an issue about our rights as citizens."
A 1994 Sino-British exchange of notes, registered with the United Nations a year later, promised that the 14 British military sites in Hong Kong would be handed over to the Chinese military after the 1997 handover.
The document vaguely stipulated that a 150-metre stretch of reclaimed harbour was to be left for construction of a naval dock. But it was not stated how far inland it would extend or whether it would be listed as a military site.
The PLA and the government have repeatedly stated that dock would be accessible to the public when not in military use.
But Chu said that under the Garrison Law, once the military had ownership of the land, there could be no legal public use and Hong Kong’s legal system could not protect anyone who knowingly or unknowingly trespassed.


text:
Question of the Day: What is the difference between red and green bell peppers?
Quick Answer: Green and red bell peppers are the same fruit, but they differ in taste and nutritional value.
Obviously, red and green bell peppers are not the same color, but that is just the tip of the iceberg. Green bell peppers are the juvenile fruit of the capsicum annuum plant, and red bell peppers are the same fruit fully matured.
Two things beyond changing colors occur when bell peppers ripen. The first is that their taste becomes sweeter, and they lose their bitter edge. This is much like the difference between green apples and ripe apples.
The second and possibly more significant change is that they pack a more potent nutritional punch. Staying on the vine longer, red bell peppers have more time to store vitamins and minerals and develop the naturally occurring compounds that make them so healthy.
While green and red bell peppers contain similar nutrient profiles, the concentrations will be much higher in red bell peppers.
Hey, I’m Joey. I’ve been cooking since I was a little kid and love everything about it. You can find my writing about food, kitchen appliances (such as blenders) and much more. Thanks for stopping by!

domain: agronomy


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text:
Ready your warp engines! The two most recent "Star Trek" films are about to be released on 4K ultra HD, just in time for the arrival of the series' new installment in theaters this summer.
"Star Trek" (2009) and "Star Trek Into Darkness" (2013) will be released in 4K ultra HD on June 14 to help celebrate the 50th anniversary of the "Star Trek" franchise, which first aired on network TV in 1966. The new releases will arrive five weeks before the newest movie, "Star Trek Beyond," hits theaters, on July 22.
"4K UHD represents the next evolution in home entertainment, offering four times the resolution and more than double the number of colors available with full HD," Paramount representatives wrote in a press release. "In addition, these spectacular 4K UHD releases deliver exceptional vibrancy and contrast through high dynamic range technology, which reveals hidden details and shades of color that more closely mimic real life."
The two films will each be released as three-disc UHD/Blu-ray/digital-HD combo packs. "Star Trek" has an extra Blu-ray disc with 3 hours of additional content, while "Star Trek Into Darkness" includes 2 extra hours, Paramount representatives said.
Among the bonus features in the two films is a tribute to Leonard Nimoy, the late actor who was best known for playing Mr. Spock in many "Star Trek" TV episodes and movies. Nimoy made appearances in both the 2009 and 2013 films and, in the bonus feature, talks about his lengthy history in the franchise, Paramount representatives said.
Other bonus features discuss matters such as casting and the series' starships, aliens and stunts. The usual theatrical trailers, gag reels, deleted scenes and extra copies of each film are also available.
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Breaking space news, the latest updates on rocket launches, skywatching events and more!
Elizabeth Howell (she/her), Ph.D., is a staff writer in the spaceflight channel since 2022 covering diversity, education and gaming as well. She was contributing writer for Space.com for 10 years before joining full-time. Elizabeth's reporting includes multiple exclusives with the White House and Office of the Vice-President of the United States, an exclusive conversation with aspiring space tourist (and NSYNC bassist) Lance Bass, speaking several times with the International Space Station, witnessing five human spaceflight launches on two continents, flying parabolic, working inside a spacesuit, and participating in a simulated Mars mission. Her latest book, "Why Am I Taller?", is co-written with astronaut Dave Williams. Elizabeth holds a Ph.D. and M.Sc. in Space Studies from the University of North Dakota, a Bachelor of Journalism from Canada's Carleton University and a Bachelor of History from Canada's Athabasca University. Elizabeth is also a post-secondary instructor in communications and science at several institutions since 2015; her experience includes developing and teaching an astronomy course at Canada's Algonquin College (with Indigenous content as well) to more than 1,000 students since 2020. Elizabeth first got interested in space after watching the movie Apollo 13 in 1996, and still wants to be an astronaut someday. Mastodon: https://qoto.org/@howellspace


The UK government has signed a deal with Becton Dickinson & Co. to obtain 65 million injection devices to prepare for a COVID-19 vaccination program. The first shipments of the injection devices have already arrived in the UK, with the full order expected to be delivered by September 2020.
Due to the need to deploy future COVID-19 vaccinations quickly, they are expected to be made available initially in single or multidose vials. This requires the use of separate needles and syringes to draw the vaccine from the vial and administer it to patients.
"BD’s dose-sparing injection devices are engineered to increase the available amount of vaccine by minimizing vaccine waste. These devices can also play an essential role in expanding available vaccine doses during a pandemic. The savings associated with lower vaccine waste are greater than the total cost of dose-sparing injection devices," BD UK&I general manager, Mike Fairbourn told Medtech Insight.
BD is the largest manufacturer of injection devices in the world. In June, the company secured its first deal with the Canadian government to supply 37 million injection devices for COVID-19 vaccines. According to Fairbourn, the company is in discussions with the US and multiple other governments around the world to supply more of the devices.
"The UK selected a device that was able to be produced and delivered in a very rapid timeframe to ensure they are prepared for whenever a vaccine is prepared," said Fairbourn. "We aren’t vaccine manufacturers, so we won’t speculate on timing, but widely published reports show a vaccine is expected late in 2020 or early in 2021."
Fairbourn said the deal is not material to BD from a financial perspective.


WASHINGTON -- A poll by a Democratic firm reveals the precarious situation facing incumbents of both parties heading into the 2012 election.
The poll, conducted by Democracy Corps, sampled 60 battleground U.S. House districts represented by Republicans and found the President is losing to Rick Perry by 4 points and Mitt Romney by 6 points.
However, by a 51-40 margin, the more that voters in those districts learn about their incumbent Republican Congressman, the less they like him or her, which is down from a 44-42 margin in March.
Dissatisfaction with the current political climate is setting up an unpredictable electoral dynamic heading into the 2012 elections.
With a divided government and some polls showing that between 70 percent and 80 percent of voters believe the country is on the wrong track, it is possible that the elections could turn the political landscape in Washington upside-down.
While President Obama faces sagging poll numbers, Congress faces approval ratings near historic lows. At this early juncture, it is plausible that the nation could end up with a Republican President and a Democratic House in 2013.
This could signal that voter discontent will be directed at their incumbent representatives, even those who were previously popular.
A poll conducted by Public Policy Polling, another Democratic group, found that Senator Scott Brown's (R-Mass.) job approval rating had dropped from a 48-36 to 44-45.
Additionally, while voters tend to give poor ratings to Congress as a whole and rate their own representatives highly, this may no longer be the case. The percentage of voters who strongly disapprove of their incumbent congressman has gone up 7 points, from 25 percent to 32 percent, since March.
The Democracy Corps poll was unusual in that it surveyed respondents from House districts carried by President Obama in 2008 but that have incumbent Republican representatives; voters were asked whether they would vote to reelect their current congressman, by name. Seventy-five percent of Democrats, 54 percent of Independents and 20 percent of Republicans said they "can't vote to reelect [the House incumbent]."


The College Democrats of Monmouth University Hope to get Campus Talking about Politics
University students are joining together to bring a College Democrats club to campus. The College Democrats of Monmouth University is an organization that will focus on spreading and promoting the beliefs of the Democratic Party and getting students more involved in the political process.
The College Democrats of America (CDOA) was founded in 1932 when President Franklin D. Roosevelt was running for office. President Roosevelt’s campaign recognized the importance of the youth vote and used that to their advantage by getting college students involved in the campaign.
It was not until 1980 that the organization became an official branch of the Democratic National Committee. Ever since then, the College Democrats of America have worked extensively on campaigns, making a huge difference in the youth vote turnout, most notably President Barack Obama’s.
Elizabeth Anderson, an upper classman at the University and one of the founders of CDMU stated, “The goals of our club are to further the Democratic cause and political activism among students who are apathetic to politics. We want to get involved in local campaigns, and are excited for the upcoming Governor’s Race.”
According to the College Democrats website, College Democrats support the views of the Democratic Party which spread from social issues to economic ones as well.
The Democratic Party has mainly advocated this year for civil rights, the environment, health insurance reform, and energy independence. Their belief is to have equal rights and opportunities under civil rights for everyone, regardless of race, gender, sexual orientation, religion, or disability.
They advocate for the LGBT communities right for Civil Unions, and having equal benefits. They also support women’s rights in health care and equal pay.
They believe in energy resources that can help not only the economy but the environment as well. By using green energy, the party believes not only will the United States become energy independent, but it will create green energy jobs that will boost the economy and protect the environment, which will act as a stepping stone to fighting climate change.
They support the President’s Health Care Reform, and that it is important to make sure we take responsibility for one another through securing Social Security and Medicare.
Until this year, there has only been a College Republicans of Monmouth University, and with the forming of the College Democrats on campus, there hopes to be more involvement from students.
Dr. Joseph Patten, Chair of the Political Science Department, believes having both groups on campus is essential. “It’s important to have thriving young Democrats and Republicans to help spread political awareness. It is really nice to have a culture here on campus with very conservative and very liberal students that can disagree on issues but still be friends.”
Anderson agrees with Patten on the importance of having both groups on campus. “You can only find the College Republicans doing all these things on campus so far, so we are so unequally represented. By starting this group, we want to have the opportunity to equally represent the views of students and the different sides of the political field.”
He continues, “The differences between the two parties can get confusing, especially if you are not too involved. We hope that by mobilizing students and getting them actively involved and engaged in politics they get a better understanding and will become more informed.”
Susan Pagano, a sophomore political science major, plans on joining the club. “I am very excited for it to get started up and running. I hope that it will spread awareness and the ideas behind the Democratic Party. It will be a fun place for people with common interest and beliefs to connect with one another and voice their opinions.”
The advisor for the club is Dr. Michael Phillips-Anderson, a professor of political communications at the University.
Phillips-Anderson is proud that the students are getting politically involved. “At a time when students are accused of apathy surrounding politics,. I’m glad that Monmouth University students are choosing to put their time and energies into forming a College Democrats Club of Monmouth University,” said Phillips-Anderson.
Phillips-Anderson continunes, “While students are often viewed as being politically conservative, and many of them indeed are, this organization should give more liberal students a chance to work together to advance their political agenda. It would be great if it led to constructive dialogue among students with different political views.”
The club has not held their first official meeting yet, but is going to soon.
If you are interested in joining the College Democrats of Monmouth University contact Elizabeth Anderson at s email@example.com for more details.


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And now it's time for BS Report Mad Libs! On (fill in the date: OCTOBER 17), a crestfallen Cousin Sal came onto the BS Report one day after his beloved Cowboys suffered a tough loss to (fill in the team: NEW ENGLAND). After rehashing the (fill in the...Blog | October 17, 2011


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Wellington enjoys flood of listings, Auckland you’re next
At Level 2, Wellington buyers were delighted to see a surge of listings late September.1 October 2021
194 Breaker Bay Road, Wellington
The whole country is rooting for you, Auckland. We can’t wait to see you regain some normality and activity when it’s safe. And just to give you a little glimpse of what life at Level 2 will be like if you’re planning to buy or sell a home, vendors outside of Auckland who have primped and prepped their homes during lockdown, are bringing their homes to the market in promising numbers.
Trade Me figures show by late September the tight Wellington regional market had taken on 428 new listings from 15 September to 29 September, seeing a jump of 10% of listings between the two weeks, the total, a remarkable leap for the capital even though it is now the spring selling season.
“Two things are going on,” says Craig Lowe, Managing Director of Lowe & Co in Wellington. “They’re people who weren’t able to get on the market at level 4 and 3 and were backed up a bit, so now we’re playing catch up. The other thing is we’re coming into the spring market.”
“People like to wait till the weather is nice, everyone does the same thing at the same time,” he says. And Wellington did have a particularly quiet winter before lockdown, he adds.
I think Auckland will see a big influx of stock at Level 2, says Craig. But people should be readying their homes now at level 3.
“At level 4 and 3, we weren’t resting on our laurels, we were making sure homes were going to be ready,” he explains.
The best time to put a house on the market is when nobody else is, he adds.
14 Hiropi Street, Newtown, Wellington,
There was an indication before lockdown that there was a huge increase in properties coming on, says Tommy’s Real Estate senior agent, Nicki Cruickshank.
Who’s selling? People are concerned that the market is changing and want to benefit from the strong interest, says Nicki. At the same time, quite a few investment property owners are quitting rental properties because they don’t want to spend the money on bringing them up to new Healthy Homes standards.
Other vendors in Wellington are selling up to go to homes in the Wairarapa and don’t want to have another lockdown in the capital, says the senior Tommy’s agent.
And there are more listings to come, she promises. Though there will be a slowdown around the school holidays starting 7 October.
Ray White Group Leaders Wellington agent Ben Stevens says the big jump of listings has had an interesting effect on buyers.
“If you’re in the market and looking, everyone believes the perfect home is just around the corner,” says Ben.
He says prices are balancing out, in line with what people are expecting rather than the extraordinary results which were happening.
Wellington needs mobile Aucklanders
The Ray White agent adds the Wellington property market is affected by Auckland’s Level 3 lockdown. As a transient city, it benefits from Aucklanders coming to live and buy homes in the capital.
“Auckland is the driver and if nothing is going on there, it does have a flow on effect,” he says.
“How Auckland comes out, how that looks and the confidence in the market will have a direct effect on us,” he explains.
Christchurch market back up and running well
Bayleys Christchurch agent Adam Heazlewood meanwhile confirmed that there was excellent activity in the garden city at the end of September.
“I’ve got a good amount of campaigns booked and a promising amount of appraisals. People are getting into the spring market vibe,” says Adam.
Christchurch saw a flood of listings last week and people are confident, he says.
132 Bristol Street, Merivale, Christchurch
“The timing is about right, we’ve warmed up, and there are only so many weeks before Christmas,” he says.
A lot of people are selling because they’re upgrading but staying local, says the Bayleys agent.
A tale of two levels
The surge of listings being seen in Wellington and Christchurch at Level 2 is playing out right around New Zealand, says Harcourts Managing Director, Bryan Thomson.
“And it shouldn't be any surprise. This is the peak selling season going into spring. There were six weeks when you couldn’t easily list, so five or six weeks of pent up listings are coming forward with Christmas crushing up at the other end, he says.
32 Buller Street, Wellington
And selling will go right up to Christmas this year, says Bryan. Christmas falls on a Saturday in 2021 so you’ll get a full week’s trading running up to that. If Christmas falls early in the week, people tend to stop buying and selling on the Friday the week before.
“With Christmas falling on a Saturday this year, we’ll get the best part of an extra week,” says Bryan.
The Harcourts MD doesn’t expect prices to change much in the coming weeks.
“Demand and supply is still out of balance. If anything, the market pricewise, has strengthened with more demand than supply so there’s no reason to expect prices to weaken with the market conditions,” he says.
Both Wellington and Christchurch markets have been very tight for some time and it will take a wee while for the volume of listings to catch up, he adds.
The Harcourts MD notes that the last time New Zealand came out of Level 4 lockdown the country was going into winter and a quieter period for the real estate business. After this lockdown, the property market has gone straight into the busy spring summer selling season.
“Teams in the field are very busy with listings coming on and there’s still a supply demand imbalance,” he says.
Hold tight, Auckland, much more to come
So take heart, frustrated buyers and sellers in Auckland. There’s much to look forward to.
And for those of you who’re keeping an eye out to see if there’s something out there to tempt you, now would be a good time to choose your agent, get your house ready to go in case something comes up that you love, and you have to move fast.


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when i was nine i noticed a stray dog roaming the neighborhood. it looked just like my neighbor's, but no one was home. i took the dog by the collar and opened their front door and let the dog inside.
as i walked away i heard their dog bark from the fenced-in backyard. i was too scared to go back. my neighbors came home to a mystery dog hanging out in their house.

domain: pet


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- How can I watch NFL in Australia 2020?
- How can I watch NFL games without cable?
- How can I watch NFL on Roku?
- What channel is the 49er game on today?
- What channel are the NFL playoffs on today?
- Can you watch NFL in Australia?
- What time and channel is the NFL on today?
- How can I watch NFL RedZone in Australia?
- What channel can I watch NFL on?
- Can I watch NFL on Smart TV?
- What time is Super Bowl in Australia?
- Can you stream NFL for free?
- Where can I watch NFL online for free?
- How can I watch every NFL game?
- Who plays in the NFL tonight?
- What channel is SuperBowl on in Australia?
- How much is NFL Game Pass in Australia?
How can I watch NFL in Australia 2020?
Watch the NFL on Free to Air Channel Seven, the free-to-air home of the NFL in Australia, has confirmed that they will broadcast live games here in 2020/21, starting from Monday the 9th of September (Sydney time)..
How can I watch NFL games without cable?
Best options to watch NFL 2020-2021 without cableNFL Game Pass: Best option (Use ExpressVPN to watch every game live without blackouts)YouTube TV (US)Sling TV (US)fuboTV (US)Hulu with Live TV (US)AT&T TV Now(US)Vidgo (US)Sky TV (UK)More items…•
How can I watch NFL on Roku?
Watch NFL Games on Roku Using fuboTVSign up for the free 7-day trial and create your login credentials.Search channels on your Roku and add fuboTV.Log in using the credentials you created.Start watching NFL games on Roku live!
What channel is the 49er game on today?
FOXWatch 49ers games live on FOX.
What channel are the NFL playoffs on today?
Beginning with the wild-card round, NFL playoff games each week were shown nationally on NBC, CBS, Fox and ESPN. The four networks each got one game during the first round of the postseason….Conference championships.Matchup49ers vs. PackersStart time6:40 p.m. ETTV channelFoxLive streamYahoo/DAZN (CA)1 more column•Jan 20, 2020
Can you watch NFL in Australia?
SUMMARY: The best way to watch the NFL in Australia is with Kayo Sports. … Along with dedicated coverage on Foxtel and the Kayo Sports streaming service, Australians can get access to every single game of the NFL season live and on demand via the official NFL Game Pass subscription service.
What time and channel is the NFL on today?
Sunday, Sept. 13TimeGameTV channel4:05 p.m. ETChargers at BengalsCBS4:25 p.m. ETCardinals at 49ersFox4:25 p.m. ETBuccaneers at SaintsFox8:20 p.m. ETCowboys at RamsNBC9 more rows•Sep 10, 2020
How can I watch NFL RedZone in Australia?
Fans can visit nflpickem.com.au to participate in the game. Further, Tabcorp and Sky Channel will bring the NFL Network and six hours of NFL RedZone programming (Monday mornings Australian time) to Australian fans across its commercial network of more than 4,400 pubs, clubs and TAB agencies.
What channel can I watch NFL on?
CBS All Access is available for your smartphone (iOS and Android), streaming devices (Android TV, Amazon Fire TV, Apple TV, Chromecast, and Roku), and game consoles (PS4 and Xbox One). Subscribers can stream from up to two devices simultaneously.
Can I watch NFL on Smart TV?
If you like watching NFL games on CBS, the company’s $6-a-month CBS All Access streaming service is really the way to go. … CBS All Access is available on streaming players, including Amazon Fire TV, Apple TV, Chromecast, and Roku; smart TVs; and game consoles, such as Xbox One and PlayStation.
What time is Super Bowl in Australia?
Where and when is it? The game will start at 10.30am on February 3 AEST (and will be broadcast on ESPN Australia and 7mate) at Hard Rock Stadium in Miami.
Can you stream NFL for free?
Just Use the NFL Mobile App The app is free on by iOS and Android and you don’t have to pay to watch to stream the games. However, the free streaming is limited to games featuring teams in your local market and the national/primetime games on Thursday, Sunday, and Monday nights on your mobile devices.
Where can I watch NFL online for free?
How to watch NFL games for free without cable. Streaming NFL games for free is easy for those using mobile devices. Free of charge, the Yahoo! Sports App presents all Sunday games being shown in your local market as well as national TV games (Thursday, Sunday and Monday nights).
How can I watch every NFL game?
NFL SUNDAY TICKET on DIRECTV is the only way to watch and stream every live out-of-market game, every Sunday afternoon. (Select int’l games excluded.) Watch live out-of-market preseason games and replay every game of the season. Stream NFL on CBS with CBS All Access!
Who plays in the NFL tonight?
NFL Week 2 scheduleGameKickoff timeTV channelWashington Redskins at Arizona Cardinals4:05 p.m. ETFOXBaltimore Ravens at Houston Texans4:25 p.m. ETCBSKansas City Chiefs at Los Angeles Chargers4:25 p.m. ETCBSNew England Patriots at Seattle Seahawks8:20 p.m. ETNBC10 more rows•Sep 17, 2020
What channel is SuperBowl on in Australia?
In Australia, the game will be broadcast on ESPN and Channel Seven, and streamed on Kayo Sports.
How much is NFL Game Pass in Australia?
You can get an Essential subscription to NFL Game Pass, priced at $148.99/year. This one includes access to live streams of NFL RedZone, as well as live game highlights and even more NFL original programming. To get the most of the service, you’ll want a PRO subscription, which costs $28.99/week.

domain: entertainment


The fuelfilter/water separator housing is located on the left side of the vehicle in front of the fueltank. See attached PDF file. EDIT: PDF file has been updated to add corrected and expanded information. Where is the fuel filter? | Jeep Garage - Jeep Forum Was this helpful?People also askWhere is the cabin air filter located on a Chevy Equinox?Where is the cabin air filter located on a Chevy Equinox?Cabin air filter is located outside of the car,under the plastic panel from passenger side of cowl. To locate and replace Chevrolet Equinox cabin air filter follow the next procedures: Remove windshield wipers or put them in upright position and then open the hood.Chevrolet Equinox cabin air filter locationSee all results for this questionWhere is in-cabin air filter located?Where is in-cabin air filter located?The cabin air filter is located on the passenger side of all Pontiac vehicles. It is either under the dashboard,in the glove compartment or under the hood,just beneath the cowl.Where Is the Cabin Air Filter Located in Vehicles | ItSee all results for this questionHow to replace cabin air filter Ford Edge?How to replace cabin air filter Ford Edge?How to Replace a Ford Edge Cabin Filter Open the passenger's side door then the glove compartment.Remove the contents from the glove compartment.Disconnect the string-hold from the right side of the glove compartment by unhooking..Reach up to the top rear sides of the glove compartment and gently push in on its sides..How to Replace a Ford Edge Cabin Filter | It Still RunsSee all results for this question Where is the fuel filter located? - 2012 Jeep Compass Oct 25, 20162012 Jeep Compass / Where is the fuel filter.. Where is the fuel filter located? (2012 Jeep Compass) When you step on the gas pedal it hesitates during acceleration. Does it sound like fuel filter needs changes or spark plugs? Teamlcwl in Russell, KS on .4.1/5(1) 2014 Jeep Compass Fuel Filter - Mopar Parts Giant MoparPartsGiant offers the lowest prices for genuine 2014 Jeep Compass parts. Parts like Fuel Filter are shipped directly from authorized Mopar dealers and backed by the manufacturer's warranty. Parts fit for the following vehicle options. Engine: 4 Cyl 2, 4 Cyl 2.


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Children’s book of the week: Hansel & Gretel by Bethan Woolvin
Hansel & Gretel by Bethan Woollvin
Two Hoots £11.99, Age 4+
Woollvin’s distinctive debut picturebook, Little Red, won the Macmillan prize for Illustration and was shortlisted for the Klaus Flugge prize and the Little Rebels award. Woollvin has specialised in alternative versions of fairy tales. She has now reworked Hansel & Gretel using her signature succinct graphic design style, with images whittled down to bold black lines and simplified shapes, plus one additional colour: this time, orange.
Despite the matching minimalism of the text, this picturebook is not for newcomers to the story. It plays with the original, making the witch kind and the children selfish and annoying. It alludes to objects in the tale we know (breadcrumbs, a chicken bone) but puts them to


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El Salvador has been on the radar of main monetary and financial establishments because it made Bitcoin a authorized tender. It has primarily change into a spectacle as cryptocurrency supporters and non-supporters alike watch on to see how this performs out. El Salvador which had made good on its bitcoin promise had made a number of BTC purchases at near the peak of the market final yr and a few this yr.
The nation now holds at the least 2,300 BTC because it made its first buy in September of 2021. Now that the worth of Bitcoin is down considerably because the nation had begun shopping for, how is that this taking part in out for the North American nation?
El Salvador And Its Bitcoin
El Salvador had purchased one other 500 BTC in May after the market had declined to $1.68 trillion. These bitcoins which had been bought at a mean value of $30,774 had introduced the nation’s holdings to 2,301 BTC up to now. It can be the bottom value that the nation had been in a position to buy the digital asset and on condition that this buy was solely a small a part of its bigger holdings, the nation nonetheless stays in loss from its a number of purchases.
Related Reading | Funding Rates Fall To Yearly Lows Following Bitcoin’s Fall Below $29,000
The first time El Salvador had purchased some BTC in September, it had been buying and selling above $44,000. What this implies is that the digital asset is down about 45% since then. Its complete stash is now price about $70 million at current costs. So even with the greenback price averaging methodology that has seen the nation purchase BTC at totally different costs, it’s nonetheless down 28% from its complete buy worth.
BTC falls to $28,000 | Source: BTCUSD on TradingView.com
The transfer to just accept BTC has not solely proved controversial on simply the bitcoin price aspect, nevertheless it has additionally affected the nation’s skill to obtain worldwide support within the type of loans.
Last yr, it was made public that the nation had been seeking to safe $1.3 billion from the IMF. However, this doesn’t appear prone to occur on condition that the IMF has expressed its disdain for the adoption of bitcoin as a authorized tender.
It has suggested the nation to take away the digital asset as an official nationwide forex, citing that this might trigger issues for the financial system within the long-term, revealing that the present account deficit for El Salvador’s remittance and the exterior financing-reliant financial system is estimated to float round $2 billion for the following three years. But President Nayib Bukele has turned a deaf ear to this.
Related Reading | Crypto Carnage Causes Flight To Bitcoin Safe Haven, Dominance Demonstrates
El Salvador is a rustic that’s closely reliant on remittances from residents overseas who ship cash house to family members. For this motive, the president has mentioned that BTC will enormously assist make these remittances simpler and cheaper for its residents.
On the worth aspect, the president just isn’t a lot bothered by the current decline both. He has mentioned up to now that he expects the worth of the digital asset to succeed in $100,000 someday in 2022. If this occurs, then the nation might be in important revenue from its BTC holdings.
Featured picture from Coingape, chart from TradingView.com
Follow Best Owie on Twitter for market insights, updates, and the occasional humorous tweet…


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About the Story"Detritus is a Twine game & formal experiment by Mary Hamilton. It is a work of fiction inspired by real-life experiences. Originally it was just meant to be five short elements, each one using a different mechanic, as a way of teaching the author the medium. It got kinda out of hand."
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Number of Reviews: 2
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A variety of mechanics involving possessions, August 20, 2019
Each part deals with your possessions, which are similar through the five parts. The people you play as seem quite different, though, unless your character is interested in both men and women and has numerous relationships, swinging back and forth between pessimism and optimism. It's possible, of course, but unlikely.
I enjoyed the game, but it felt a bit bloodless. All of the characters seemed kind of distant emotionally. But all of the scenarios are ones in which characters themselves are removed emotionally from their immediate surroundings, whether through shock or relief.
Finally, some of the background images made the text hard to read. But there is certainly something appealing about the game.
a moving story about moving, June 12, 2017
A surprisingly moving little story, it's a reflection about what objects have meaning to you, what they say about you as a person, and what it means to let go of your belongings, your current life, and your identity.
If you enjoyed Detritus...
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Hypertext stories that make heavy use of text transformations by Bruno Dias
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