text:
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Ligand Pharmaceuticals Incorporated (NASDAQ:LGND) announced that data from preclinical studies evaluating LG-7501 were featured in a poster presentation today at the 63
rd Annual Meeting of the American Association for the Study of Liver Diseases in Boston. Ligand is developing novel small molecule inhibitors of NS5B polymerase for the treatment of hepatitis C virus infection (HCV) using its HepDirect
™ liver-targeting technology platform. LG-7501 is a HepDirect prodrug designed for increased liver targeting, potentially improving clinical efficacy and safety.
In preclinical studies, Ligand evaluated the pharmacokinetics and liver targeting of LG-7501. LG-7501 is a HepDirect prodrug of 2’-C methylguanosine, a clinically validated NS5B polymerase inhibitor. HepDirect liver targeting of 2’-C methylguanosine and other active nucleosides may be an effective method to improve efficacy while reducing systemic side effects in HCV treatment. LG-7501 efficiently targeted the liver with reduced systemic distribution in preclinical models, providing proof-of-concept with a clinically validated HCV treatment.
The key findings include:
LG-7501 has good oral bioavailability in two species.
LG-7501 is rapidly metabolized to the active drug.
LG-7501 converts to the active drug in the liver, resulting in greatly increased liver concentrations of the active drug while greatly reducing systemic distribution.
“Our HepDirect liver-targeting technology platform is an exciting example of Ligand’s diverse portfolio of un-partnered assets and technologies, and has applicability in preferentially targeting drugs to the liver across a range of new classes of compounds for diseases such as HCV,” commented Matthew W. Foehr, Chief Operating Officer of Ligand Pharmaceuticals. “Additionally, we are extremely pleased with the positive data generated in preclinical evaluation of LG-7501. HCV represents a significant and growing health concern, with few therapeutic options currently available for the approximately 180 million patients infected with the disease worldwide
About Ligand’s HepDirect HCV Inhibitor Program
HepDirect is a pro-drug technology that targets delivery of certain drugs to the liver by using a proprietary chemical modification that renders a drug biologically inactive until cleaved by a liver-specific enzyme. Antiviral therapies for the treatment of HCV often have significant undesired side effects related to systemic exposure of the compounds. The HepDirect technology may improve the efficacy and/or safety of certain drugs and can be applied to marketed or new drug products.


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Xlife Sciences AG (XLS): Antiviral drug candidate
A portfolio project of Xlife Sciences AG (XLS) is developing a promising drug candidate against SARS-CoV-2 as well as other flu viruses. The active ingredient inhibits the viral replication and acts against infection related inflammatory processes. It is already in use in humans.
Research & Development is actively looking for Covid-19 therapies around the world. In this way, the aim is to focus on reducing viral replication in early stages and to treat inflammatory effects at a later stage.
The drug candidate developed by the portfolio project company of Xlife Sciences AG has shown that it can offer an alternative therapeutic approach in several phases of the disease, as it both reduces the viral load and inhibits inflammation in the body.
Oliver R. Baumann, CEO of Xlife is delighted about the latest results: "We are very confident that the medical drug can be used in various phases of Covid-19 due to its specific properties and are pleased to contribute to fighting the global pandemic". Baumann added that it can be assumed that the active principle can be transferred to other respiratory viruses as well. This is subject to further research.
According to Xlife, the drug candidate has efficiently reduced the viral load of lung cells infected with influenza in several cell experiments. Tests with SARS-CoV-2 pathogens have also shown a high level of effectiveness. In addition, various inflammatory processes in the body have been effectively combated. The active ingredient is already being used in humans.
About Xlife Sciences AG
Xlife Sciences AG is a Swiss company with focus on investing in promising technologies in the life science industry. Xlife Sciences AG is building the bridge from research and development to healthcare markets by supporting researchers and entrepreneurs in positioning, structuring, developing and implementing their concepts. Together with industrial partners or universities, Xlife Sciences AG leads projects through the proof-of-concept phase after an invention disclosure or start-up. Subsequently, the firm focuses on out-licensing or selling the company, often with a combination of a strategic partnership. Xlife Sciences AG offers its investors direct access to the further development of innovative and future-oriented technologies at a very early stage. For more information, please visit: www.xlifesciences.ch
Xlife Sciences AG
0041 44 385 84 60
Regulated Unofficial Market in Frankfurt, Munich
EQS News ID:
For media inquiries:
Oliver R. Baumann, CEO Xlife Sciences AG, Tel.+41 44 385 84 60
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domain: news


text:
Balinese Buddha Sculpture
I have him placed in the center of a lovely enameled tray surrounded with rose petals. He always brings a smile.
This is Precious! Love it very much. It is as stated. I will cherish it for years to come. I will purchase from this artist again. Thank you for sharing your talent with us.
Hand Made Wood Sculpture from Indonesia, "Buddha's Gesture"
Tropical Balinese Laughing Buddha Wood Sculpture, "Happy Buddha in a Hat"
Hand-Carved Crocodile Wood Buddha Statuette from Bali, "Buddha Relief"
Hand Carved Wood Buddha Statuette from Bali, "Samadhi Buddha"

domain: artistic


text:
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MOSCOW, December 27. /ITAR-TASS/. Russia's Prime Minister Dmitry Medvedev has signed a directive "On the Provision of Subsidies for the Development of Regional Air Transportation of Passengers and Formation of Regional Air Route Networks".
In 2014, provision is made for 4.2 billion rubles of resources for subsidizing regional air transport, with 3.58 billion rubles being earmarked for implementing the signed directive.
The text of the document has been place Friday on government’s website.
The mechanism for subsidizing an air transportation route has been adopted as a basis for the rules of providing subsidies from the Federal budget to air transport organizations for regional air transportation of passengers in Russia in 2014-2016, says a report of the Cabinet of Ministers.
The rules set out an extension of the list of hub airports up to 18.
"The parameters of a subsidized air route are kept intact: 1,800 km — if a hub airport is located in the territory of the Far Eastern District (FEFD) and 1,200 km in the territories of other Districts. Introduced additionally is a mechanism of co-financing together with the constituent entities of the Russian Federation. In the event of co-financing, the length of an air route is not limited," the government report said.
This approach ensures full coverage of Russia's territory by a network of air transportation routes with minimum requirement for budget appropriations for subsidizing, the report points out.
The annual passenger traffic on a subsidized air route should not be more than 8,000 passengers, and 10,000 passengers for the FEFD. The exception for FEFD is accounted for by the lack of alternatives to air transport there.


text: If you're searching for a lawn care Manchester, NH, company that puts its customers first, look no further than Highest Quality Lawn Care, Inc. of Manchester, NH. Highest Quality Lawn Care, Inc. of Manchester, NH, opened our doors in 2000. The owner is a degreed horticulturalist and has been in the industry of lawn care since 1986. He has a certificate from the University of Georgia as a certified turf grass manager. Our business has had a steady growth since the beginning and we still maintain some of our customers from 2000. If you want the best lawn care of Manchester, NH, come to us. The thing that sets us apart from our competition is the fact that our employees are top quality. Each of our employees is screened before hiring and are constantly being trained on the newest lawn care trends. We are unique because we are always keeping up with current trends in lawn care. We use the best products and equipment for the most effective lawn care treatment. Of our many great lawn services the popular is the lawn fertilization program. We use a mostly liquid fertilizer for the best benefits. We take a preventative approach with blanket applications when it comes to weed and grub control. We also provide insect control which includes flea and tick control as well as perimeter pest control. Highest Quality Lawn Care, Inc. also performs core aeration and core aeration with overseeding along with tree and shrub care. We will also do soil testing in order to see your lawn's pH. We also have an organic lawn care program. We do everything a traditional lawn care company does. You can put your lawn in our hands. We stand behind our work. We will guarantee that a licensed staff member will come out and perform their best professional work. If you want your lawn being the healthiest and best it can be give us a call to speak to one of our professional and trained lawn technicians to become another one of our happy customers. We can't wait to get started.

domain: agronomy


text:
UPDATED 1/17, 11:40 a.m. ET: Rabbi Charlie Cytron-Walker, one of the four hostages held at the Texas synagogue by an armed British national, said his captor became “increasingly belligerent and threatening” as the situation wore on.
As the Associated Press reports, Cytron-Walker said he was thankful for his security training provided by the congregation over the past few years. “In the last hour of our hostage crisis, the gunman became increasingly belligerent and threatening,” said Cytron-Walker in a statement. “Without the instruction we received, we would not have been prepared to act and flee when the situation presented itself.”
The captor has been identified as 44-year-old Malik Faisal Akram. He was killed after the hostages were able to escape the synagogue on Sunday, although authorities haven’t revealed who shot him as the investigation is still ongoing.
Authorities have since revealed Akram arrived in the United States on a tourist visa in recent months. Counter-terrorism police in the United Kingdom have confirmed they are in communication with those in the U.S. It’s not clear why Akram chose the synagogue, but audio from a Facebook livestream indicated he was demanding the release of Pakistani neuroscientist Aafia Siddiqui, who has been convicted for suspected ties to al-Qaeda.
UPDATED 1/16, 11:55 p.m. ET: On Twitter, Gov. Greg Abbott confirmed all the hostages were safe and released. They were held for 11 hours.
See original story below.
Authorities say they’re negotiating with a man who has taken multiple people hostage at a Texas synagogue.
According to CNN, the situation unfolded during Saturday services at the Congregation Beth Israel in Colleyville, located about 30 miles outside of Dallas. Officials say the incident was partially captured on a Facebook livestream, in which a man could be heard apologizing to the hostages and making several remarks about Islam. Sources say the synagogue began livestreaming its services in wake of the COVID-19 lockdowns. More than 8,000 people were reportedly watching the stream before it was pulled.
Though police have yet to determine a motive, the livestream audio suggests the man was calling for the release of Aafia Siddiqui, a convicted terrorist who is believed to be his sister.
In 2010, Siddiqui was convicted of trying to kill U.S. officers in Afghanistan. The Pakistani woman is now serving an 86-year prison sentence in a Texas facility. Siddiqui’s attorney, Marwa Elbially, told CNN her client “has absolutely no involvement with” the hostage situation.
“She does not want any violence perpetrated against any human being, especially in her name,” Elbially told the network. “It obviously has nothing to do with Dr. Siddiqui or her family.”
Authorities have not publicly identified any of the hostages, but believe a rabbi is among those being held. The hostage taker made the rabbi call another rabbi in New York. The call was meant to demand the release of Aafia Siddiqui.
At around 6 p.m. ET, one of the hostages was released. Colleyville Police Department Sgt. Dara Nelson told CNN the man was unharmed: “FBI Crisis Negotiators continue contact with the subject,” Nelson said.
As of press time, no injuries or shots have been reported, and investigators are still unclear whether the suspect is armed.
“We are currently conducting SWAT operations around the 6100 block of Pleasant Run Rd,” the Colleyville Police Department told CNN. “All residents in the immediate area are being evacuated. Please avoid the area. We ask that you continue to avoid the area. We will continue to provide updates via social media.”
A number of political figures have responded to the situation, including Dallas Mayor Eric Johnson, Texas Governor Greg Abbott, and White House Press Secretary Jen Psaki.
The FBI is also on the scene, assisting with the negotiations. A loud bang was heard according to people on the scene, followed by a short blast of rapid gunfire coming from the direction of the synagogue. Texas officials confirmed the hostage taker was armed and has died.

domain: law


text:
BARRICADE® is a revolutionary product,
developed to assist firefighters and property owners to control
and extinguish fires, and to protect exposures from burning.
Utilizing the latest in technology, BARRICADE has been
proven to dramatically improve and forever change the science of
firefighting and exposure protection.
During recent years, the problems encountered
during urban interface fires have made headlines around the world.
Devastating fires have cost lives and caused millions of dollars
worth of damage to homes, businesses, and other structures. The
development of BARRICADE will now enable our communities to
better control these destructive fires and to reduce the
tremendous loss of life and property.
BARRICADE is a liquid concentrate
composed of super absorbent polymers. These super absorbent
polymers can absorb hundreds of times their weight in water.
It is this characteristic that gives BARRICADE it's
tremendous ability in firefighting.
BARRICADE is intended to be used in
diluted form. When the BARRICADE concentrate is
added to water at a rate of 1 to 6%, a unique fire-blocking
gel is produced. The BARRICADE gel, when applied
to a combustible structure or material, provides an insulating
zone between the heat of the fire and the protected surface,
even at temperatures of 3500° Fahrenheit! The thermal
protective ability of BARRICADE is far superior to
anything previously available to suppress fires and to protect
To fully understand the revolutionary properties
of BARRICADE, it helps to examine the protective
gel coating on a microscopic basis. As BARRICADE
and water are sprayed onto an exposed surface, millions of
tiny bubblets© are stacked one on top of
behavior is similar to that of AFFF or Class A foams,
except that BARRICADE bubblets are water filled,
whereas foam bubbles are only air filled. These unique
water filled bubblets dramatically enhance the thermal
protective qualities of BARRICADE over that of
standard foam products. In order for the heat of the
fire to penetrate the protected surface, it must burn off
each layer of the BARRICADE bubblets coating.
Each layer holds the heat away from the next layer of
bubblets beneath. The polymer shell of each bubblets
and their stacking behavior significantly impede water
evaporation. As a result, BARRICADE can
provide thermal protection from fire for extended periods
even at 3500° Fahrenheit.
BARRICADE is specifically
formulated to adhere for long periods to most
horizontal and vertical surfaces, including walls,
roofs, ceilings, overhangs, glass windows,
compressed gas cylinders, railroad tank cars,
motor vehicles, watercraft, aircraft, trees, brush,
shrubs, plants, and grass. BARRICADE will
continue to adhere to protected surfaces even in
high wind conditions.
BARRICADE may be prepared in
the same manner as firefighting foams using standard
foam eductors. It can be applied using
standard hoses and nozzles or master stream devices.
There is no extensive training or special equipment
needed to start using BARRICADE today.
Using BARRICADE with water
represents a dramatic improvement over the use of plain
water alone. For every gallon of plain water that
leaves the nozzle, at least 90% runs off vertical
surfaces due to gravity and plain water's poor ability
to penetrate many fuels. In contrast, BARRICADE
treated water adheres for long periods to vertical
surfaces and greatly reduces water runoff.
When water alone is used to combat
large, hot fires, most of the water pumped through the
master stream device never reaches the seat of the fire.
The water evaporates and turns into steam in the
superheated air above the fire. When BARRICADE is
mixed with water, the evaporation process is
significantly slowed. As a result, more fire
quenching water is able to get through the superheated
air and reach the seat of the fire.
When plain water is used to cool and to
penetrate combustible surfaces, or to extinguish fire
inside a burning structure, latent heat inside the
structure often evaporates water, allowing the
combustible surface to ignite or to re-ignite after
initial extinguishment. It is the unique
characteristics of BARRICADE which reduce water
runoff, slow the evaporation process, and create a
thermal protective gel coating that adheres for long
time periods to vertical surfaces, and dramatically
reduces the chances of a fire rekindling. As a result,
the use of BARRICADE treated water to combat
fires will prove to be much more effective and safer
than using plain water.
BARRICADE® also represents a
significant technological improvement over traditional
foam products. Foaming agents are mixed with air
and water to produce air bubbles in a process known as
aeration. Tests have demonstrated that air bubbles
burst when exposed to temperatures in the range of 170°
In contrast, when BARRICADE is
mixed with water, a hydration, rather than aeration,
process takes place. BARRICADE is made up of tiny
polymers that are similar to dry sponges. During
the hydration process, these polymers soak up water
resulting in millions of tiny drops of water surrounded
by polymer shells. The result is not really a bubble,
because a bubble is air surrounded by liquid, nor
however, is the result a droplet, because a droplet is
simply a small drop of water. Consequently, we
have coined the word "bubblets©",
i.e., a drop of water surrounded by a polymer shell.
OF THE PRODUCT AND THE COMPANY
BARRICADE® FIRE BLOCKING GEL
BARRICADE INTERNATIONAL, INC.
12848 S.E. Suzanne Dr. Hobe Sound, FL 33455
Tel: (772) 546-5364 Fax: (772) 546-0465
ON INGREDIENTSIdentification of the preparation: Anionic
water soluble polymer
Hazardous characteristics (irritation) were observed
only in the product when tested as a whole, not in
IDENTIFICATIONIrritation to eyes and skin.
Spills produce extremely slippery surfaces.
MEASURESInhalation: Move to fresh air.
Skin Contact: Wash off immediately with soap and
plenty of water. In case of persistent skin
irritation, consult a physician.
Eye Contact: Rinse thoroughly with plenty of
water, also under the eyelids. In case of
persistent eye irritation, consult a physician.
Ingestion: The product is not considered toxic
based on studies on laboratory animals.
MEASURESSuitable extinguishing media: water,
water spray, foam, dry powder, carbon dioxide (CO2)
Special fire-fighting precaution: Spills
procedure extremely slippery surfaces.
Protective equipment for firefighters: No special
protective equipment required.
RELEASE MEASUREPersonal precautions: No special
protective equipment required
Environmental precaution: Do not contaminate
Method for cleaning up: Do not flush with
water. Dam up. Soak up with inert absorbent
material. If liquid has been spilled in large quantities
clean up promptly by scoop or vacuum. Keep in suitable
and closed containers for disposal. After cleaning,
flush away traces with water.
STORAGEHandling: Avoid contact with skin and
eyes. When preparing the working solution ensure there
is adequate ventilation. When using, do not smoke.
Storage: Keep in a dry, cool place (0-30°C).
When preparing the working solution ensure there is
adequate ventilation. Freezing will affect the physical
condition and may damage the material.
CONTROLS / PERSONAL PROTECTIONEngineering controls: Use local
exhaust if misting occurs. Natural ventilation is
adequate in absence of mists.
Personal protection equipment
- Respiratory protection: In case of insufficient
ventilation wear suitable respiratory equipment.
- Hand protection: Rubber gloves
- Eye protection: Safety glasses with side
shields. Do not wear contact lenses
- Skin protection: Chemical resistant apron or
protective suit if splashing or contact with solution is
- Hygiene measure: Wash hands before breaks and
immediately after handling the product. Handle in
accordance with good industrial hygiene and safety
Form: viscous liquid
pH: 6-8 @ 5g/l for product series.
Melting point (°C): Not applicable
Flash point (°C): > 100°
Autoignition temperature (°C): >200°C
Vapor pressure (mm Hg): 0.002 @ 20°C
Bulk density: 1500 cps maximum
UL Viscosity: 1-2 cps
Density (weight): 8.78 pounds per gallon
Specific Gravity: 1.054
Stability: Products stable, No hazardous
polymerization will occur.
Materials to avoid: Oxidizing agent may cause
Hazardous decomposition products: Thermal
decomposition may produce: carbon oxides, nitrogen
- Oral: LD50/oral/rat> 5000 mg/kg
- Dermal: The product is not expected to be toxic
in contact with the skin.
- Inhalation: The product is not expected to be
toxic by inhalation.
- Skin: Irritating to skin.
- Eyes: Irritating to eyes.
- Sensitization: The product is not expected to
- Chronic toxicity: Prolonged skin contact may
de-fat the skin and produce dermatitis.
INFORMATIONFish: LC50/Fathead minnows/96h >
Algae: EC50/72h/Phaeodactylum tricornumtum >
Daphnia: LC50/48h/Chaetogrammus marinus = 15 mg/l
Bioaccumulation: The product is not expected to
Persistence / degradability: Biodegradable in
sunlight (40% after 28 days)
BOD: 2700 mg/l
COD: 2265 mg/l
CONSIDERATIONSWaste from residues / unused products: In
accordance with federal, state and local regulations
Contaminated packaging: Rinse empty container
with water. Can be land filled or incinerated,
when in compliance with local regulations.
INFORMATIONNot regulated by DOT
INFORMATIONAll components of this product are on the
TSCA and DSL inventories.
RCRA Status- not a hazardous waste
Hazardous waste number- not applicable
Reportable Quantity (40 CFR 302)- not applicable
Threshold Planing Quantity (40 CFR 335)- not
HMIS and NFPA Ratings- Health (1), Flammability
(1), Reactivity (0)
INFORMATIONPerson to contact: Regulatory Affairs
The information provided in this Safety Data Sheet is
correct to the best of our knowledge, information and
belief at the date of its publication. The
information given is designed only as a guidance for
safe handling, use, processing, storage, transportation,
disposal and release, and is not to be considered a
warranty or quality specification. The information
relates only to the specific material designated and may
not be valid for such material used in combination with
any other materials or in any process unless specified
in the text.

domain: chemistry


text:
We have this delicious one especially for Valentine’s Day low-carb cranberry bars made! These soft bars made of almond flour and filled with cranberries and nuts are fun to surprise your loved one, but also super tasty to enjoy yourself. The balanced combination of fresh, sour and sweet makes these bars so special and delicious.
Make cranberry ‘bars’
These cranberry bars are not hard bars, but soft bars with a cake structure. The base consists of almond flour, eggs, cream cheese, butter and the natural sweetener erythritol. We obviously have almond flour and erythritol our own brand for best results. The bars are filled with pecans and fresh cranberries. Finally, we covered the bars with a layer of melted white chocolate. However, you can also leave this out if you want to watch the calories a bit more. In short, a delicious low-carbohydrate delicacy for coffee or tea.
When using a white chocolate bar, you get a thin layer of white chocolate on the bars. We recommend using two bars for a thicker layer. Without the chocolate, a bar contains 213 kcal and 2.5 g carbohydrates. You can replace the pecans with walnuts. The cranberry bars will keep in the fridge for at least 3 to 4 days. You can also freeze them by the bar. I hope you like it! Check out our others for more inspiration snack recipes.
- Preheat the convection oven to 170 degrees. Add the cream cheese (soft), butter (soft), erythritol and vanilla extract to a bowl. Then beat this with an electric mixer until fluffy. Then add the eggs while beating and mix well.
- Now take another bowl and mix in the almond flour, baking powder and a pinch of salt. Now add the flour mixture to the bowl with the eggs and mix well. Then cut the pecans into small pieces and stir the nuts into the batter.
- Line a large square baking pan with baking parchment. Spoon half of the batter into the baking tin. Then add the cranberries and cover with the last bit of batter. Bake the cake in the preheated oven for about 40 to 45 minutes. Check with a skewer whether the cake is done.
- After baking, remove the cake from the oven and let it cool completely. Then melt the white chocolate au bain marie. Grab a saucepan and fill it with a layer of water. Bring to a boil and place in a heatproof bowl containing the chocolate. Melt and spread over the cake in the baking tin.
- Let the chocolate harden on the counter and then completely in the refrigerator. Cut the cake into 6 bars and cut each bar in half, so that you have 12 bars in total. Enjoy your meal!
- Portion size: 1 bar (1/12)
- Calories: 254
- Fats: 22.1
- Carbohydrates: 3.4
- Protein: 6.9

domain: food


text:
All Hallows' Eve
Of all of the Vivian Vande Velde books I picked up and read voraciously over the week of Christmas, All Hallows' Eve was by far my favorite. Tragic and gruesome (but not explicitly so), filled with horror and Vande Velde’s trademark surprises, it’s a collection of 13 wonderfully scary short stories—some of them so short you can read them in less than 10 minutes—that any thrill lover would be happy to read.
This was my first time experiencing real horror at Vande Velde’s hands. I’ve read some stories where she displayed elements of horror and crime, but never stories that were horror at their center. I think she needs to venture into this territory more often because she does it quite well.
One of my favorite stories in the book features a misleading title—don’t they all when it comes to Vande Velde?—and a building tension, a creeping dread, that makes me shiver and want to read it all over again at the same time. I love tension building in scary books and movies—any books and movies, really, as long as it’s done well; that’s why I’m such a fan of No Country for Old Men, Mystic River, and other films many people consider simply “slow.” Make no mistake: this story is far from slow. All of the stories in the book carry a quick pace that is sure to wow you and keep you up at night—not from reading, as it’s a fast read, but from staring into the dark, waiting, waiting…


Mizuno, the Japanese golf equipment manufacturer renowned for its performance products, has unveiled new and improved versions of its popular Nexlite and WAVE Cadence golf shoes for SS19 – the Nexlite Boa 006 and WAVE Cadence GTX – plus an extended apparel collection featuring three high-tech fabrics.
Mizuno’s new Spring Summer 2019 golf footwear and apparel collections boast improved versions of the popular Nexlite and WAVE Cadence shoes, plus a range of stylish yet simple apparel designs featuring elegant silhouettes in a selection of classic, plain colours, tailored from Solar Cut, Quick Dry and Move Tech high-performance fabrics.
The new SS19 WAVE Cadence GTX is the ultimate long-distance golf shoe, designed to go 36 holes and beyond. Based on Mizuno’s award-winning running platform, the WAVE Cadence GTX blends the comfort and support of a high-end running shoe, with the lateral stability and traction needed in golf. For SS19, the WAVE Cadence GTX will feature GORE-TEX® for the first time. This world-renowned membrane provides optimum footwear climate comfort thanks to its perfect marriage of durable waterproofness and optimised breathability that keeps feet both dry and comfortable.
The WAVE Cadence plate is engineered to handle uneven terrain with ease while providing a secure foundation for the golf swing. Added durability and traction come via Mizuno’s extremely hardwearing X10 carbon rubber that allows high-impact areas in the heel to last longer and perform better. WAVE Cadence GTX also features U41C, a unique, extremely light midsole compound engineered for high comfort and performance, plus the IG Multi Technology (Impact Grip System), engineered to deliveradded grip and stability throughout the swing in firm conditions, and specifically through impact, by spreading the force created in the golf swing more evenly across the foot. It also boosts comfort.
The WAVE Cadence GTX will be available in four colours: White, Grey, Navy/Grey and Black.
The Nexlite Boa 006 is a waterproof, spikeless golf shoe that shares the same WAVE platform technology as the WAVE Cadence GTX. This ultra-lightweight shoe features the Boa closure system instead of traditional laces, which makes it easier to put the shoes on and take them off, with the Boa dial tightening and releasing a durable Nylon-coated stainless steel wire lace that won’t stretch. For SS19 the new Nexlite Boa 006 will feature a fine-touch Kuraray upper that will be softer to the touch than in previous Nexlite models.
The Nexlite Boa 006 will be available in four colours for men: White, Black, White/Blue and White/Navy. There will also be two ladies’ options: White/Sky Blue and White/Turquoise.
One the apparel side, three different performance fabrics lead the way in Mizuno’s extended SS19 collection: Solar Cut, Quick Dry and Move Tech. Solar Cut Technology helps cool the body from the heat and ultraviolet light rays exerted by the sun by suppressing the transmission of not only infrared rays but also ultraviolet rays which are the cause of sunburn. It also suppresses the transmission of light, which improves cooling performance. Mizuno Quick Dry absorbs and diffuses moisture quickly, wicking moisture away from the skin while letting cool air in to keep the inside of the clothes more comfortable for the wearer. And Move Tech is Mizuno’s 4-way stretch fabric with specific material placement for ease of movement, incorporated into anatomical patterns.
Mizuno’s SS19 apparel collection features two Solar Cut polos and four Quick Dry polos. The Solar Cut Panel Polo is a lightweight summer shirt incorporating Solar Cut technology into a stylish yet simple design, while the Solar Cut Polo features a WAVE Cadence-inspired print. Both are available in four vibrant colours.
The Quick Dry collection comprises: a Quick Dry Textured Polo featuring a three-button deep placket, a button-down collar and a sophisticated subtle stripe design in four colours; a lightweight Quick Dry Stripe Polo with a twisted stripe design in a stretch fabric, also in four colours; and the Quick Dry and Quick Dry Plus polos with stretch properties, both available in six classic colours.
For those spring or summer days when a single layer is not enough, the Move Tech jacket and vest are the perfect companion, offering excellent showerproof and windproof protection in a fabric engineered to allow complete freedom to swing. Both stylish full-zip garments are perfect for those early morning starts or twilight rounds. They are woven from 100% polyester and are available in three striking colours: Light Grey, Black and Reflex Blue. The Move Tech Trouser and Short are also available in the same three colourways, woven from a polyester/polypropylene blend. Two caps complete the collection – the RB Cotton Twill, available in five colours, and the Print Mesh, with its WAVE Cadence-inspired peak design, available in four colours.
Mizuno’s SS19 footwear and apparel collections with be available at retail from March 2019.


Trey Flowers knows he has to be more focused on wrapping up. The senior defensive end was caught in…
Bielema Seeks Reward for Hard Work
When Arkansas hosts Nicholls this Saturday at Reynolds Razorback Stadium, it will be a match-up of two teams that have lost a combined 17 straight games. But head coach Bret Bielema – whose team has lost 10 straight since he won his first three at the helm of the Razorbacks – sure doesn't sound like a defeated guy on the SEC Teleconference on Wednesday as his program look for its first win since...
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INSIGHT MM: a large, global, prospective, non-interventional, real-world study of patients with multiple myeloma
Costello C, Davies FE, Cook G, et al. INSIGHT MM: a large, global, prospective, non-interventional, real-world study of patients with multiple myeloma. Future Oncol. 2019; 15(13):1411-1428. doi: 10.2217/fon-2019-0013.
With the introduction of new drugs with different mechanisms of action, multiple myeloma (MM) patients' outcomes have improved. However, the efficacy seen in clinical trials is often not seen in real-world settings and data on the effectiveness of MM therapies are needed. INSIGHT MM is a prospective, global, non-interventional, observational study that is enrolling approximately 4200 patients with newly diagnosed or relapsed/refractory MM, making it the largest study of its kind to date. The study aims to describe contemporary, real-world patterns of patient characteristics, clinical disease presentation, therapies chosen, clinical outcomes (response, treatment duration, time-to-next-therapy, progression-free and overall survival), safety, healthcare resource utilization and quality of life. One interim analysis has been conducted to date; current accrual is approximately 3094 patients. Trial registration number: NCT02761187.

domain: medical


text:
This Hollywood powerhouse, who lost their teenage son last month, is slowly coming to terms with the loss believing that life has to go on for the sake of their daughter, Ella.
According to People Magazine —
“(They are) regrouping and pushing through the grieving process. They are trying to grieve and return to some sort of normalcy for Ella. But life isn’t normal without Jett.”
The couple lost their teenage son on January 2nd.

domain: sociology


text:
Pastor Walther / Aug 27, 2017 / Unexpected / 1 Kings 19:9-18 / Pentecost 12
In what world does evil triumph over good? Everything seemed to be upside down. It was so unexpected. Bloodied by the carcass of a bull that he had just slaughtered; dusty from the stones of the altar that he had pieced together; his clothes, his beard and his hair smelling of charred flesh; his face sweaty because of the heat caused by the Lord’s fire; Elijah, the prophet of God had a showdown. Elijah wanted to demonstrate God’s power to 850 prophets of two false gods named Baal and Asherah. He went before the Israel people who had grown indifferent to the differences between these false gods and the true God. So, Elijah sets up the scenario where there were two altars, one for the true God and one for the false Baal. The first to get their God to burn up the offering on the altar wins. In short, God absolutely humiliates the enemy. The false prophets attempted to call out to their false god Baal but nothing happened. There was no response. God on the other hand, heard Elijah’s prayer and burned everything including the altar. If there was a scoreboard, it would say: God, a million; enemies of God, zero. The people fell on their faces and said, “The Lord, he is God!” With such an awesome display of power, how couldn’t people be amazed by God and his power? You would think that such a display of power would have to change hearts and minds. At least, that was Elijah’s expectations, and that would probably be our expectation. We look at the creation around us and see the beauty that God has created, or the miracle of someone surviving a lethal car crash without a scratch and think, how can people not believe that there is a God, right?
But what he expected, what you and I would have expected, was so far off. Instead of a great religious revival, the king and queen threatened to kill Elijah by the next day. With the stench and sweat still in his clothes and in his hair, Elijah fled for his life and fled for a mountain which was very familiar to the history buffs of Israel. He flees to the exact mountain that Moses had been on 600 years before. On this mountain, the Lord had appeared in the burning bush to Moses and later where the Lord gave the ten commandments.
Now, after such an unexpected turn of events, Elijah holes himself up at this famous mountain, doing something also so unexpected. Growing up you kind of think of prophets or even pastors or teachers or even parents as being robots, unable to express any emotion. God shows in our text here for today though how emotionally exhausting it was for prophets to see their people not listening. Elijah breaks down crying because he feels as if he has failed his people, failed his job, and failed God. You can see the pain that pastors have for their people when the people stop coming to church and when bible classes are empty. You can see the pain of our Christian teachers when their students take the gospel home that they learned at school to a family that couldn't care less about the gospel. I’m sure you have felt that same pain when you have invited someone to church or shared the hope that you have with someone, and they laughed in your face or threw your invite into the trash. Elijah was not some emotionless robot but he was like you and me. This failure weighed heavily on him as failure often does and in his depression, he honestly believed that he was the only godly prophet left in Israel. Everything that he had done, the famous showdown against the prophets of Baal before our section, felt like a waste of time and effort.
My situation felt like a waste of time and effort to me. Maybe it was something I said. Maybe I didn’t use the right bible passage. Maybe I didn’t say something well enough. It seemed like all my attempts to share the gospel with an acquaintance of mine failed. I think about all the different avenues of ministry that we have tried at St. Paul to reach out to the community that sort of just didn’t work out, or all the missions that our synod started but we had to close. Was it all just a waste of time and effort to share the gospel? Was it all just a waste of time and effort for Elijah to preach to his people? You and I, and Elijah alike, do something so expected in this world: we begin to make our expectations based on our work, based on our toil and effort, based on our time, based on the correct wording that we put to persuade someone to become Christian, rather than trusting in God and his plans.
At a certain point, you kind of just wish every unbeliever would have a Martin Luther experience being caught in a lightning storm to scare them into becoming Christians. God doesn’t necessarily work that way, though. Interestingly, when God had given the 10 commandments on this mountain 600 years before, he DID demonstrate his powerful, terrifying presence with fire, smoke, and an earthquake. He created fear and awe, and the people saw that the threats of God’s law were not empty. Occasionally, God does use hurricanes, tornadoes, earthquakes, etc. as his tools. He uses them to put fear and awe in the hearts of his people and to test them, and at times he uses them also to judge the ungodly. Maybe Elijah expected to meet this same threatening God, who could demonstrate his power.
But God was not in the destructive blast of the wind, the shaking earth, or the intense heat of the fire. He didn’t announce his presence with thunder. More often than not, God comes to us in the means of his own choosing: at the manger, at the cross, at the empty tomb, in the gentle whisper of his word, and all of it wrapped in the beautiful gospel. Our God is a God who can demonstrate his power, but our God is also a “compassionate and gracious God, slow to anger, abounding in love and faithfulness.” This whisper that Elijah heard was God’s patience with his people, as opposed to violent destruction. This is the God who wins his people over with the amazing words that our salvation is through the innocent blood of Jesus on the cross.
In his word, God asks us to do something unexpected. He asks us to trust him. The salvation of souls is not dependent on us and how well we can be persuasive or how well we can touch the emotions of someone, but that it is dependent on him and his word. That is a truth that we have to learn time and time again as sometimes we can become impatient with the slow growth of a church, as we become impatient with sharing the gospel with a family member or a friend who doesn’t want to hear about Jesus. When we fail to see growth, we may feel tempted to change the message, or choose not to share certain parts because we don’t want to offend people. Maybe we are tempted to make Jesus into a show, an experience, something that you have to feel with fire, and wind, and earthquakes of production and yet forget about the whisper of the gospel, the whisper of God’s word. Thankfully, faith in our heart doesn’t come about by our doing or choosing, and the faith that I want in someone else’s heart doesn't come about by my hard work, but it comes through hearing the word and hearing the law and gospel.
It is inevitable that some people will choose to reject God’s Word. As painful as it may be Jesus promised that people would reject his word. Yet, God also promised us that his word changes hearts and minds. The whisper of God’s word is always working and is always effective. We see the beautiful and unexpected patience that God has for his people, even when we are too stubborn to trust in him, even when it may seem like we have failed. What was unexpected to Elijah was that there were at least 7,000 people who believed in the true God! That’s like the size of my hometown that Elijah just skimmed over and didn’t realize had hear that whisper of the gospel. Was all the time and effort that Elijah put in worth it? Was all the rejection that he had dealt with worth it? Yes! We look back at the different avenues of ministry at St. Paul that outwardly looked like they failed, but maybe one person heard and believed in the gospel. Was all the time and effort sharing the gospel worth it! Yes! Faith will never grow if the whisper of God’s word isn’t preached.
We have to trust that it is by God’s power and his word that people come to faith, which is why we need to continue as well to be fed and nourished by this amazing and unexpected whisper. If we want to share with other people the life giving gospel, we need to be well fed too! At this point, Elijah was spiritually starving from the lack of the gospel. Yet again, we see God acting so unexpectedly. He didn’t strike Elijah down with power and the law, but he restored Elijah with the gospel, the reminder that we have been forgiven for all our failures, all the time we relied on ourselves rather than trusting in God and his power. Our God always restores us with his gospel, but he also doesn’t let us wallow in our failures.
People’s rejection of us or of God’s word does not mean we have failed God and it surely doesn’t mean that our task is over. God gives us purpose to continue to share God’s word. During his time, much like many other prophets, Elijah was hated and wanted dead. He felt that impact. Yet, through God’s word he continued his purpose of sharing God’s message, even when people didn’t want to hear it. Elijah wasn’t supposed to stay in that cave forever. When we face “failure” with our sharing of God’s word, God encourages us with the same gospel and reminds us to keep sharing the gospel. God does not relieve us of our responsibilities and maybe encourages us to try different avenues of ministry, but always preaching God's word.
30 years. It took 30 years for a man that I knew, a husband of a family, to start coming to church and become a member. 30 years of denying the whisper of the gospel. 30 years of sitting at home alone while the rest of the family was at church. 30 years for his life to change. One day as a secret to his family, he began taking Bible information class with the pastor to learn more about Jesus and on his wedding anniversary, announced to his family that he had become a member at the church. It was so unexpected.
I can’t help but be amazed that the Lord graciously comes to sinful people, people who fail in so many different ways, like you and me, and Elijah, but equips us again and again by that whisper of the gospel to serve him and to be preachers of his Word! When you leave today, do not by saddened by our failed attempts to share God’s word, or maybe the hypocrisy you might feel thinking why would people want to listen to me when I’ve messed up so much in my personal life!? But be renewed by his gospel and his wonderful encouragement like this bible account so that we are reminded that we are forgiven and that we continue to share that message again and again to as many people as we can. The world around us expects us to fail as Christians. But God’s love is so unexpected. Amen.

domain: literature


Grover robot does the heavy lifting in high-tech greenhouses
With large high-tech sustainable farming facilities located in Northern California and Texas, Silicon Valley-based startup Iron Ox relies heavily on robots to help shoulder the workload. The company's latest bot, named Grover, can lift over 1,000 lb (454 kg).
Not to be confused with NASA's polar exploration robot of the same name, Grover was designed in-house by Iron Ox's team of engineers.
The squat-bodied wheeled device features a unique type of rocker suspension, plus a differential drive system in which steering is managed by selectively actuating individual wheels. It autonomously makes its way around the greenhouse facilities via multiple LiDAR scanners, along with both upward- and forward-facing cameras.
The cameras also allow Grover to identify the 1,000-lb, 6 by 6-foot (1.8 m) hydroponically irrigated modules in which the various fruits and vegetables are grown. When the robot locates a target module – which sits propped up on four legs – it proceeds to precisely position itself underneath, then utilizes a motorized lift system to raise the module completely off the floor.
Grover then transports the module to a robotic scanning booth for automated inspection. If needed, the robot may subsequently carry it to other stations for additional watering, nutrient supplementation, or harvesting.
According to Iron Ox, implementation of the highly-efficient robot should allow the company to use less water, energy and land. The technology should also let the company promptly respond to market demand, as different crops can quickly be harvested – day or night – as needed.
Source: Iron Ox
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text:
Three new Sri Lanka records by Chinthana Vidanage
Commonwealth Games gold medallist Chinthana
Vidanage set three new Sri Lanka records to finish on top of Group C
in the men's 69kg category of the weightlifting competition of the
XX1Xth Olympic Games at the Beijing University of Aeronautics &
Astronautics Gymnasium here on Monday.
Sri Lanka win final Test to take Series 2 -1
Sri Lanka waltzed to a richly deserved eight
wicket victory over India in the final Test and also a series
clinching 2-1 victory at the P.Sara Oval yesterday, 65 minutes after
tea on the fourth day.
The changes brought good results - Mahela
Sri Lankan captain Mahela Jayawardena said that
the appearance of a couple of new players helped them win the
deciding third and final test match and the series 2-1 against the
touring Indian team concluded at the P. Saravanamuttu Stadium

domain: sports


WASHINGTON (AP) — The Senate has scheduled vote for Friday on a temporary spending bill required to prevent a government shutdown.
The chamber will also vote on a tea party-backed provision to defund Obamacare, but only if it defeats a filibuster by Sen. Ted Cruz and others. They're filibustering the bill because a vote to end debate gives Democrats controlling the chamber a big procedural edge.
But many Republicans are poised to break with Cruz since the alternative is to kill the bill altogether and force a partial government shutdown at midnight on Monday.
Top GOP leaders say the House will not simply approve the Senate measure and ship it to the White House, but they haven't said for sure what they may return to the Senate.
Copyright 2013 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
Newport News Police are still looking for a killer more than four years after a 17-year-old was shot dead.
An Amtrak train carrying more than 40 passengers was involved in an accident with a car Thursday morning in Waverly.
A boil water advisory has been issued in Corolla after a water line break.


text:
Nearly half of adults reported problems with care coordination, notification of test results, and communications between primary care providers and specialists, and one-third said the health care system was poorly organized Stremikis et al.
One of the significant points of the book is that planning is paramount. Without trust, risk tolerance will be low, as will combat effectiveness.
These duties may include drug management, wound care, rehabilitation, and lifestyle changes CFAH, There are a number of ongoing efforts to improve shared decision making. Public and private payers should incorporate population health improvement into their health care payment and contracting policies and accountability measures.
However, there are three additional levels of public morality equally important. Learning from Others Calling a group of assembled people a team does not make them one.
As noted in this chapter, there are differences between patient involvement in care and measures such as patient satisfaction. All these questions figure into deciding the appropriate level of care. Clinicians should fully communicate gaps in the evidence base to their patients during the medical decision-making process.
It is a fast read, too, useful if time is short. Ensuring that patients have the tools they need to manage health information is critical, as lower levels of health literacy have been associated with increased hospitalizations, greater use of emergency rooms, lower use of preventive services, and limited ability to manage complex treatment regimens Berkman et al.
Coordinating Patient Care Throughout the Health Care System and Community Opportunities exist for bridging the gaps between patients, their care, and the broader community. Therefore, it is essential that every team member is clear about his or her own role as well as the role of every other team member.
Promoting patient self-management can facilitate shared decision making and improve cancer care. Self-care has become increasingly crucial as patients today are discharged from health care organizations more quickly and in poorer health. They are more than words-they are the moral, ethical, and professional attributes of character.
According to a study, however, only 6. Their efforts aid patients in becoming more educated and informed consumers, and aid clinicians in staying abreast of clinical advances by disseminating clinical guidelines and decision support tools.
Improving Shared Decision Making Using Decision Aids One of the important functions of communication in cancer care is ensuring that patients make decisions that are consistent with their needs, preferences, and values. Essential regulation includes the licensure of health care providers at the state level and the testing and approval of pharmaceuticals and medical devices by the U.
Communities of integrated health services, spanning organizations and clinicians, are an example of the evolving definition of communities—in this case focused on care coordination.
Knowing they would need to invest in developing team skills and attitudes, these companies turned team development into a part of their corporate strategy, making them enterprise-wide initiatives.
Communicating Information and Preparing Cancer Care Plans To achieve high-quality cancer care, the cancer care team needs to effectively communicate and engage in shared decision making with patients to ensure that patients understand their disease, know their care options, and develop a plan for care.
If a team gets these things right, it will raise the probability of success and therefore achieve its desired outcomes. One reason is the complexity of the issues leaders deal with, and the difficulty in many instances of determining which is the most ethical alternative.
For public officials, there is an additional reason why it is important to adhere to these basic moral codes and laws: One is groupthink, which can occur in a homogeneous group with a strong leader. Additional research is necessary to assess the duration of effectiveness of this training Moore et al.EARLY CHILDHOOD ENVIRONMENTAL EDUCATION PROGRAMS: GUIDELINES FOR EXCELLENCE Guideline —Play and the role of adults ing ones.
The overall goal of these guidelines is to chart an appropriate and positive process whereby. MISSION. The mission of the Department of Defense is to provide a lethal Joint Force to defend the security of our country and sustain American influence abroad.
Assessment is an integral part of instruction, as it determines whether or not the goals of education are being met. Assessment affects decisions about grades, placement, advancement, instructional needs, curriculum, and, in some cases, funding.
Sepucha and colleagues (, p) argued that the “quality of a clinical decision, or its patient-centeredness, is the extent to which it reflects the considered needs, values, and expressed preferences of a well-informed patient and is thus implemented.”. A high level of cooperation is a product of choices — choices made one person at a time for reasons that are often unique to the team member.
results. It’s a short list. In fact, it contains only six characteristics, but each one plays a specific and vital role in making the team effective.
If any one of them is missing or inadequate. The author of Being Mortal: Medicine and What Matters in the End is Atul Gawande. He is an eminent American surgeon and author, who conducts research into public h I read this book a fortnight ago, by my brother's bedside, at a time when both he and I knew he was dying/5.Download


text:
Microgaming is a big software provider for the online gambling business. In the past three years, Microgaming has launched many new slot machine games and also the classic three reel slot machines.
Every of the three slots have their own features and themes. They range from oceanic fishing to witchcraft to adventure. The classic three reel slots are best casino games for the beginner players as they have a straight format.
The coin range is from 20 cents to 1 dollar. There are 27 winning combinations of symbols and the bar black sheep symbol is very important one. The bar bar black sheep symbols on the pay line make the winning mixtures.
There is the bulls eye which is a three feet single pay line slot machine based on the darts game. The only coin size accessible is a one dollar coin. There are usually 24 winning blends of symbols and the dart symbol and it is very important for all.

domain: entertainment


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2020 - 2021 Student Fellows
I am very excited to be writing my first-full length play under the mentorship of Professor Willenbrink. The play, taking place in a small town, is about two brothers wrestling with a betrayal from the past, and questioning each other's intentions and identity.
My Humanities Fellowship project will make students more aware of the significance of the art found on The University of Scranton campus – and throughout Jesuit spaces worldwide - in an effort to develop a friendship with the arts that incorporates the Ignatius Examen outside the walls of the Theology 121 classroom.
This project will investigate the role of spirituality in a cura personalis approach to medicine. I will engage philosophical, psychological, and theological principles, and will investigate historical and current trends in medicine.
I will analyze the impact of personal experience on the portrayal of schizophrenia among Latinx authors. I will also study the literary history of schizophrenia within the Latin-American realm, and I will posit plausible causes for the lack of literary frameworks on mental disorders.
My project will study the complex relationship between the medical field and Christian theology. I will study the philosophy of medicine in the ancient world, before the dawn of Christianity. Second, I will consider these topics and evaluate how Christian ethics and Ignatian spirituality have a place in modern medicine. All of this will help to develop a philosophy of medicine that is genuinely humanistic in its approach and thoroughly dedicated to caring for the sick.
My project will recognize the forgotten voices of three important female philosophers of the 17th century: Anne Conway, Margaret Cavendish, and Princess Elizabeth. I will deal with vitalism, panpsychist, aesthetics, materialism, and Cartesian dualism. I will also draw on the work of of their male counterparts: Hobbes, Leibniz, and Descartes.
This project is a narrative essay of my personal experience with and perspective of the Shipsky family, a farming family from Clifford, Pennsylvania, that is grounded in love, their Byzantine Catholic faith, and honest, hard work. It will document how my experience with them had a profound impact on my life.
This project is a poetry collection developed around gender and sexuality. The primary goal of this project is to explore themes of gender through a dialogue between the poet and a character invented for the project, named Blair.
My project explores the relationship between the American Civil War and the evolution of the American Catholic identity. Through analysis of different Catholic orders and communities, I have synthesized a thesis on the birth of the modern American Catholic identity forged not only along the Potomac but in the halls of Congress. My research points to a unique identity for Catholic Americans and the beginning of a greater church movement that will eventually be realized as Catholic Democracy.
For this project I will be researching the letterforms found in ancient manuscripts and coins up to 1600 CE. Each of the manuscripts and coins will be digitized in order to more closely observe the lettering. There will be a physical exhibition of the manuscripts and coins, on loan from a private collection, on the fifth floor of the Weinberg Memorial library come Spring 2021 along with an online exhibition through the University’s website.


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There’s much to celebrate this year. To help celebrate, Oklahoma State University's Symphonic Orchestra is kicking off their concert series “Season of Celebrations” with their concert “Looking Back, Moving Forward” Thursday at 7:30pm in the Seretean Center.
Thomas Dickey, the conductor, plans to have each concert this season celebrate historic milestones while also highlighting important and underrepresented composers.
“I want the audience to know that the OSU Symphony Orchestra is committed to lifting up and celebrating all types of composers and performers, ranging from familiar names like Haydn and Beethoven, to the Native American and African American communities who inspired Dvora,” Dickey said. “We are also quite excited about our upcoming concerts that will celebrate female composers and composers of color.”
Thursday night’s concert highlights include “The World on the Moon” by Fraz Joseph to honor the 50th anniversary of the landing on the moon and Heather Lanner performing Beethoven’s 3rd Piano Concerto for an early celebration of Beethoven’s 250 birthday. It will also include the centennial of the 19th amendment and Dvorak’s “New World” Symphony inspired by Native American melodies and African American spirituals.
Tickets are $7 for students and $10 for general admission.


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Half a century ago, construction workers began transforming a bare patch of Encinitas earth into this region’s first hospital. Today, a yearlong celebration kicks off to mark the 50th anniversary of Scripps Memorial Hospital Encinitas.
Caregivers, former patients and community leaders gathered at the hospital May 3 to share memories, give thanks and unveil a historical photo display of the facility. Scripps also announced it will collect hospital-related mementos from the public during the next year for a time capsule, which will be deposited at the medical campus next spring.
The historical photo display will be available for public viewing inside the hospital. For the time capsule, the hospital is seeking small items from the public related to the hospital’s first 50 years, such as photos, letters and other remembrances. Details for submitting items to the time capsule will be announced soon.
“In 1963, our founding physicians broke ground on this hospital to meet the health care needs of North County, because they had the vision to see this region as a vibrant, growing area,” said Chris Van Gorder, president and CEO of Scripps Health. “This hospital is rooted in the spirit of providing superior care to our patients, which is a legacy that continues to this day.”
What began as a convalescent care facility and has grown over the years to become a full-service hospital that offers a wide range of clinical and surgical services.
The earliest days of Scripps Encinitas can be traced to 1960, when Dwight Cook, MD, and the late Charles Clark, MD, bought property on Santa Fe Drive and Devonshire Road to build a small medical-dental building for their practice. They soon realized the community needed to expand its health care infrastructure, so they turned to patient and friend Herman “Pop” Wiegand, who put up his Bank of America stock as collateral for a loan to build a hospital on the same property. Groundbreaking for the hospital took place in 1963.
In spring 1964, the doors opened to the 60-bed Encinitas Convalescent Hospital, which was licensed to provide long-term care for patients recovering from illness or surgery but unable to remain at home. Later that year, the hospital’s third founding physician, Ronald Summers, joined the practice of Drs. Cook and Clark. They obtained a medical specialty license and converted some of the long-term care beds to acute care beds, enabling them to start taking care of medical illnesses. By 1966, the hospital was upgraded to a specialized hospital for internal medicine and was renamed Encinitas Hospital.
Bigger plans for the hospital lay ahead. In 1967, the founding doctors bought an adjoining parcel of land to the north for future development. Eight years later, they entered into a partnership on a major hospital expansion, which added full medical-surgical capabilities, an intensive care unit, a comprehensive emergency department and raised its capacity to 94 beds. The newly named San Dieguito Hospital opened in 1975.
As the business of health care underwent major changes, the founding physicians realized they needed more support to sustain and grow the hospital. They approached Scripps Health about purchasing the facility, based on their familiarity with Scripps’ high standards of care and commitment to serving the community. The sale to Scripps was completed in 1978, and the facility was renamed Scripps Memorial Hospital Encinitas.
“I’m pleasantly surprised and quite grateful to see how the hospital has developed over the years to provide a wider range of services,” said Dr. Summers. “Our main goal in the first place was to serve the health care needs of the community, and Scripps has done a tremendous job of taking what we started and helping it grow.”
Medical facilities at the hospital were again expanded in 1992, including the addition of a birth pavilion, second-floor rehabilitation, an enlarged emergency department, a new main lobby and more than 60 new acute-care beds.
Today, Scripps Encinitas receives more than 80,000 patient visits per year and offers a broad spectrum of services. These include complex neurological and vascular procedures, 24-hour emergency care and heart, cancer, orthopedic and rehabilitation services.
Scripps Encinitas is North County’s first Joint Commission-certified primary stroke center and offers the first brain injury rehabilitation program in San Diego, Imperial and Riverside counties accredited by the Commission of Accreditation of Rehabilitation Facilities. It is also certified as a STEMI (ST-Segment Elevation Myocardial Infarction) receiving center for patients having a heart attack, which helps ensure patients receive the fastest and most effective care possible.
To meet the region’s steadily increasing demand for health care services, Scripps Encinitas is currently expanding with the construction of a Critical Care Building. The new structure will more than double the size of the hospital’s emergency department with 27 emergency room beds and will add another 36 medical-surgical beds on its second floor. Work on the 61,643-square-foot building is expected to be complete in 2014.
Learn more about Scripps Health.


Jackson City Council members voted 5-1 to repeal the ordinance Tuesday night, following a campaign by opponents to put the ordinance to a public vote. City Council member Kim Jaquish, 2nd Ward, was absent.
Council members originally approved the ordinance March 12, which called for all Jackson residents to use a trash hauler that contracts with the city. Currently, residents are free to choose any number of garbage haulers to pick up their refuse, or dispose of it themselves.
Last month, opponents of the ordinance turned in a petition in an attempt to repeal the ordinance by way of a public vote.
Recently verified by Jackson City Clerk Andrew Wrozek, the petition required City Council members to either repeal the ordinance or put the issue to a public vote on the Aug. 6 primary ballot.
Jackson Mayor Martin Griffin tallied the only "no" vote.
"I think it should have gone to a public vote," Griffin said. "I'm confident it would have passed."
After seven trash haulers attended a mandatory pre-bid meeting April 22, Granger and Republic Services were the only two haulers to bid on the job.
Both Griffin and City Council members Michelle Woods, 1st Ward, said the bids that came in would have had residents pay about $57 per quarter, and included trash pickup and recycling.
"I thought that the bids that came in were extremely high," Woods said, echoing the sentiments of most City Council members at the meeting.
The majority of council members said they voted to repeal the ordinance because the bids were too high, but made it clear that while the original ordinance is now repealed, the possibility of another single hauler ordinance remains.
"I think there is community support for the single hauler system," City Council member Derek Dobies, 6th Ward, said. "I see this as a first attempt – a start to a conversation."
Woods voted against the ordinance when it initially passed in March but said possibly voting "yes" on a single hauler ordinance in the future is not out of the question.
"If we're able to come forward with something that's plausible and beneficial for everyone, I would vote in favor of it," she said.
Greer said the single hauler system is still something that city officials will pursue.
"The idea isn't dead," he said. "There's a lot of support out there for it."
Contact Will Forgrave at firstname.lastname@example.org or 517-262-7554. Follow him on Twitter at @WillForgrave.


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African tick bite fever
|African tick bite fever|
Leg lesion after Rickettsia africae infection
|Classification and external resources|
African tick bite fever (ATBF) is a tick-borne disease caused by Rickettsia africae in sub-Saharan Africa and the West Indies. The bacterium is transmitted to humans by ticks in the Amblyomma genus. African tick bite fever is a type of spotted fever. Symptoms, when present, typically occur within 4–10 days of transmission and can include a fever, headache, rash and inoculation eschars at bite sites. The clinical symptoms are typically mild and resolve within 3 weeks. Complications are exceedingly rare.
The diagnosis of African tick bite fever is often based on clinical signs and symptoms. Definitive diagnosis is made by culture, PCR, or immunofluorescence. Data about the appropriate treatment of ATBF is limited. Symptoms tend to be mild and resolve on their own. However, when people seek medical treatment, physicians may treat the infection similarly to other rickettsial infections, such as Rocky Mountain spotted fever.
Signs and symptoms
African tick bite fever is often asymptomatic or mild in clinical presentation and complications are rare. The onset of illness is typically 5–7 days after a tick bite though the range of symptom onset is 4–10 days. Symptoms can persist for several days to up to three weeks. Common presenting symptoms include:
- Muscle aches
- Inoculation eschar(s)
- Swollen lymph nodes near the site of the bite
- Maculopapular and/or vesicular rash
- Prolonged fever > 3 weeks in duration
- Reactive arthritis
Rickettsia africae is a gram-negative, obligate intracellular, pleomorphic bacterium.
In Sub-Saharan Africa, the most common vectors of R. africae are two species of hard ticks, Amblyomma variegatum and Amblyomma hebraeum. Other species of Amblyomma in sub-Saharan Africa can also transmit R. africae and it may be that up to 100% of Amblyomma ticks in sub-Saharan Africa carry R. africae. Amblyomma ticks are most active from November to April. These tick species frequently feed on cattle and other livestock, but can also be found feeding on wild animals in areas where farm animals are not found. Unlike other hard tick species, which passively seek hosts, the Amblyomma hard ticks actively seek out hosts. These ticks are known to be more aggressive, and several ticks may attack at once, leading to clusters of African tick bite fever cases within groups of persons traveling or working together.
Up until 1998, it was thought that only ticks in sub-Saharan Africa carried R. africae. However, a case of locally transmitted African tick bite fever in the French West Indies led to the discovery of R. africae within Amblyomma variegatum ticks on Guadelupe Island. Now, R. africae has been isolated from ticks on several Caribbean islands, though the only cases in humans in the Caribbean have occurred in the French West Indies. Recently, R. africae has also been found in Amblyomma loculosum ticks in Oceania.
After the rickettsia bacteria infects humans through a tick bite, it invades endothelial cells in the circulatory system (veins, arteries, capillaries). The body then releases chemicals that cause inflammation, resulting in the characteristic symptoms. The hallmark of all rickettsial diseases is a histology (cellular) finding called lymphohistiocytic vasculitis that involves immune cell deposition into the cells that make up vessels. This occurs secondary to the chemicals mentioned above, and damage from the infection, and involves signals to immune cells (T cells and macrophages) to come to the site of the infection.
Rickettsia bacteria species like R. africae replicate around the area of the initial tick bite, causing necrosis (cell death) and lymph node inflammation. This is the cause of the characteristic eschar.
Many patients with ATBF who live in areas with a high number of infections (Africa and the West Indies) do not visit a doctor, as most patients only have mild symptoms. This disease can, however, cause more serious symptoms in travelers who have never been exposed to the Rickettsia africae bacterium before and are not immune. Travelers who present to a doctor after a trip to affected areas can be hard to diagnose, as many tropical diseases cause a fevers similar to that of ATBF. Other diseases that may look similar are malaria, dengue fever, tuberculosis, acute HIV and respiratory infections. In addition to questions about symptoms, doctors will ask patients for an accurate travel history and whether he/she was near animals or ticks. Microbiological tests are available for doctors, but are expensive and often must be done by special laboratories.
The antibiotic treatment available for rickettsiae infections has very few side affects, so if a doctor has a high suspicion of the disease, he or she may simply treat without doing more laboratory tests.
Diagnosis of ATBF is mostly through clinical signs and symptoms, as many laboratory tests are not specific to ATBF. Common laboratory test signs of ATBF are a low white blood cell count (lymphopenia) and low platelet count (thrombocytopenia), a high C-reactive protein, and mildly high liver function tests.
Biopsies or cultures of a patient's tick wound (eschar) are used to diagnose ATFB. However, this requires special culture media and can only be done by a laboratory with biohazard protection. There are more specialized laboratory tests available that use quantitative polymerase chain reactions (qPCR), but can only be done by laboratories with special equipment. Immunoflorescence assays can also be used, but are hard to interpret because of cross-reactions with other rickettsiae bacteria.
Treatment and prevention
African tick bite fever is usually mild, and most patients do not need more than at-home treatment with antibiotics for their illness. However, because so few patients with this infection visit a doctor, the best antibiotic choice, dose and length of treatment are not well known. Typically doctors treat this disease with antibiotics that have been used effectively for the treatment of other diseases caused by bacteria of similar species, such as Rocky Mountain Spotted Fever.
For mild cases, patients are usually treated with one of the following:
If patients have more severe symptoms, like a high fever or bad headache, the infection can be treated with doxycycline for a longer amount of time (100 mg orally 2 times daily for 7 days).Pregnant women should not use doxycycline or ciprofloxacin as both antibiotics can cause problems in fetuses. Josamycin has been used effectively for treatment of pregnant women with other rickettsial diseases, but it is unclear if it has a role in the treatment of ATBF.
Cases of African tick bite fever have been more frequently reported in the literature among international travelers. Data examining rates in local populations are limited. Among locals who live in endemic areas, exposure at a young age and mild symptoms or lack of symptoms, as well as decreased access to diagnostic tools, may lead to decreased diagnosis. In Zimbabwe, where R. africae is endemic, one study reported an estimated yearly incidence of 60-80 cases per 10,000 patients.
Looking at published data over the past 35 years, close to 200 confirmed cases of African tick bite fever in international travelers have been reported. The majority (~80%) of these cases occurred in travelers returning from South Africa.
- Boutonneuse fever
- Rocky Mountain spotted fever
- Flea-borne spotted fever
- List of cutaneous conditions
- "Chapter 174. Rickettsial Diseases | Harrison's Principles of Internal Medicine, 18e | AccessMedicine | McGraw-Hill Medical". accessmedicine.mhmedical.com. Retrieved 2016-12-01.
- Parola, Philippe; Paddock, Christopher D.; Socolovschi, Cristina; Labruna, Marcelo B.; Mediannikov, Oleg; Kernif, Tahar; Abdad, Mohammad Yazid; Stenos, John; Bitam, Idir (2013-10-01). "Update on Tick-Borne Rickettsioses around the World: a Geographic Approach". Clinical Microbiology Reviews. 26 (4): 657–702. doi:10.1128/CMR.00032-13. ISSN 0893-8512. PMC . PMID 24092850.
- Jeremy Farrar, Peter Hotez, Thomas Junghanss, Gagandeep Kang, David Lalloo, Nicholas J. White (2013). Manson's Tropical Diseases. Elsevier Health Sciences. p. 279. ISBN 9780702051029.
- Binder, William (2015). "African Tick-Bite Fever in a Returning Traveler". The Journal of Emergency Medicine. 48: 562–565 – via Science Direct.
- Jensenius M, Fournier PE, Kelly P, Myrvang B, Raoult D (September 2003). "African tick bite fever". Lancet Infect Dis. 3 (9): 557–64. doi:10.1016/S1473-3099(03)00739-4. PMID 12954562.
- "African Tick-Bite Fever | Disease Directory | Travelers' Health | CDC". wwwnc.cdc.gov. Retrieved 2016-12-07.
- Fournier PE, Roux V, Caumes E, Donzel M, Raoult D. (1998). "Outbreak of Rickettsia africae infections in participants of an adventure race in South Africa". Clin Infect Dis. 27(2): 316–23.
- Caruso, G.; Zasio, C.; Guzzo, F.; Granata, C.; Mondardini, V.; Guerra, E.; Macrì, E.; Benedetti, P. (2002-02-01). "Outbreak of African tick-bite fever in six Italian tourists returning from South Africa". European Journal of Clinical Microbiology & Infectious Diseases: Official Publication of the European Society of Clinical Microbiology. 21 (2): 133–136. ISSN 0934-9723. PMID 11939395.
- Valbuena, Gustavo; Walker, David H. (2016-12-05). "Infection of the endothelium by members of the order Rickettsiales". Thrombosis and haemostasis. 102 (6): 1071–1079. doi:10.1160/TH09-03-0186. ISSN 0340-6245. PMC . PMID 19967137.
- Procop, Gary W.; Pritt, Bobbi. Pathology of Infectious Diseases: A Volume in the Series: Foundations in Diagnostic Pathology. Elsevier Health Sciences. ISBN 9781455753840. Retrieved 7 December 2016.
- Toutous-Trellu, Laurence (2003). "African tick bite fever: Not a spotless rickettsiosis!". Journal of the American Academy of Dermatology. 48: S18–S19.
- Brouqui, P.; Harle, J. R.; Delmont, J.; Frances, C.; Weiller, P. J.; Raoult, D. (1997-01-13). "African tick-bite fever. An imported spotless rickettsiosis". Archives of Internal Medicine. 157 (1): 119–124. ISSN 0003-9926. PMID 8996049.
- Humar, A.; Keystone, J. (1996-04-13). "Evaluating fever in travellers returning from tropical countries". BMJ (Clinical research ed.). 312 (7036): 953–956. ISSN 0959-8138. PMC . PMID 8616312.
- "Tips From Other Journals - American Family Physician". www.aafp.org. Retrieved 2016-12-02.
- Frean, J.; Blumberg, L. (2007-11-01). "Tick bite fever and Q fever - a South African perspective". South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde. 97 (11 Pt 3): 1198–1202. ISSN 0256-9574. PMID 18250937.


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Jeanie's Bargain Alerts
A Wine and Grill Bargain Alert from Jeanie - 20/04/2011
Until tomorrow (Thursday) you can get a £35 wine voucher for just £15. You can spend the voucher on a good selection of wines from 3pm on Friday. Many of the wines are already reduced and you can see the selection on www.winedeal.co.uk (you do have to pay for delivery but it is still good value)
Click here to see this Voucher Offer
You can get a George Foreman Grill reduced from £29.99 to just £11.49 and delivery is FREE!
Click Here to see this Offer.
There are also lots more new offers with massive discounts (some 90% off) from Reader Digest and we have listed them on Top Tips - Click Here
Share on Facebook

domain: hobby


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Oct. 23 – Nov. 6, 2020
** New digital restoration! **
An unsentimental elegy to the American West, Sweetgrass follows the last modern-day cowboys to lead their flocks of sheep up into Montana’s breathtaking and often dangerous Absaroka-Beartooth mountains for summer pasture. This astonishingly beautiful yet unsparing film reveals a world in which nature and culture, animals and humans, vulnerability and violence are all intimately meshed.
“A tenaciously observed and a quietly absorbing ethnography about a pair of shepherds leading some 3,000 sheep on a 150-mile journey up into Montana’s Absaroka-Beartooth Mountains for summer pasture.” – Sukhdev Sandhu, Daily Telegraph
“The images, including sheep on the move up near vertical hills, are remarkable, the landscape spectacular, the unsentimental account of back-breaking, backside-aching work impressive.” – Philip French, Guardian
“This beautiful and hypnotic documentary shows the agony and the ecstasy of herding sheep up into Montana’s Beartooth mountains for the summer pasture.” – Peter Bradshaw, Guardian
“Strange to relate that one of the year’s most striking cinematic experiences so far is a documentary starring 3,000 sheep.” – Kieron Corless, Sight and Sound
“It would be foolish not to experience this film.” – Dominic Radcliffe, Little White Lies
Description courtesy of Grasshopper Film.


Intorno Alla Mia Cattiva Educazione Mellow 2006. Intorno Alla Mia Cattiva Educazione Imports 2016. Sort: Recent best-seller Results cached. Intorno Alla Mia Cattiva Educazione" born as Opera, as a screenplay, inspired to a character/puppet (that was scrambled in yhe concert during the busiest pieces) which has suffered a puritan education, unable to live and think freely. Another Concept album with complex texts and sophisticated arrangements.
Album · 1973 · 13 Songs. Intorno Alla Mia Cattiva Educazione Alusa Fallax. Listen on Apple Music.
ALUSA FALLAX are amongst the ranks of Italian prog bands who only released one album in their career, perhaps surprising when you realise the band existed for around ten years. They then started playing live shows but it wasn't until 1974 that the album "Intorno Alla Mia Cattiva Educazione" was released. Musically the album is largely in a symphonic style with classical and occasional jazz influences, with intelligent utilization of acoustic and electric instrumentation. Although comprising of thirteen tracks they are divided into two long suites with strong musicianship throughout. The album received very little promotion and was only pressed in a quantity of 5000.
Artist: Alusa Fallax Title: Intorno Alla Mia Cattiva Educazione Year Of Release: 1974/1992 Label: Crime Genre: Art Rock, Prog Rock Quality: Mp3 320, Flac (image,. The band kept playing and released their one and only album in 1974 on Fonit; a great little-known gem, in the best Italian prog tradition, led by keyboards with classical influences, it reminds the best things Banco del Mutuo Soccorso ever made. No less than 13 tracks are listed on the label, but these are connected to form two long suites very well played and sung, and with interesting lyrics.
Intorno Alla Mia Cattiva Educazione. This song is by Alusa Fallax and appears on the album Intorno alla mia cattiva educazione (1974).
You're viewing YouTube in Russian. You can change this preference below. Provided to YouTube by Fonit Cetra WMI. Intorno alla mia cattiva educazione · Alusa Fallax. Intorno alla mia cattiva educazione. 1974 Fonit Cetra Spa - A Division of Warner Music Group Company. Percussion, Vocals: Dutj Cirla Producer: Giovanni Fonio Bass, Vocals: Guido Cirla Guitar, Vocals: Guido Gabel Saxophone, Vocals: Mario "Giondo" Cirla Piano: Massimo Parretti Arranger: Alusa Fallax Composer: Massimo Parretti.


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FAQFrequently Asked Questions
Where do I meet you in Merzouga ?
in front of Morocco National 4×4 auto museum
How long to reach the camp when I arrive in Merzouga ?
- 15 to 20 mn by 4×4
- 40 mn by camel
Do I need a 4WD car to reach the camp ?
YES, only 4×4 can take the sand tracks to get to the camp,
What is the best time to arrive ?
It depends on the season, best is to plan your arrival before sunset :
SEPT-OCT :4h30 PM NOV-FEB :3h00 PM
APRIL :4h30 PM MAY-JUN :6 PM
- JULY-AUG : 7 PM
At what time is sunrise / sunset ?
How long is the trip from Marrakech or Fes ? How many kilometers ?
- 470 km from Fes – 8 hours drive
- 368 km from Ouarzazate – 5 hours drive
- 127 km from Errachidia – 2 hours
- 53 km from Erfoud – 50 mn
Do you have any recommendation or advise for our stay in the desert?
Always have sun cream with you (any season), sun glasses, cap or hat, long sleeves
Do you have WIFI in your camp?
Yes, we do offer Wi-fi in the camp to ley you enjoy and share all your moments with the world!
Do you have electricity, can we plug in our phone on the spot?
Do you have special menu for vegetarian or in case of dietary restrictions?
Get in touch
+212 700 534 537
Mohammed Taghlaoui, Khamlia Ohasso,

domain: travel


A presidential election is not an exercise in democracy; it is an abdication of democracy. Every four years, those who care to, enter a voting booth and sign off on both their right to influence policy and their very awareness of it. It is this abdication that has enabled you to make such a creative use of the Offal Office.
Even though we are a one-party system, I must admit that the Democratic faction has a tougher row to hoe. Democrats have to pay lip service to public participation, Republicans don’t. The trouble is that every once in a while a Democratic candidate surfaces who actually takes this nonsense seriously. This is why we have to contend with bamaobama this time around.
The good news is that for all of its natter about democracy and “the people”, the Democratic Party is still run by party hacks. The smoke-filled room has been replaced by the super delegate’s Blackberry. And therein is the salvation of the country.
Okay, so during the touchy-feely Sixties the big talk was about “power to the people” and all of that bullshit. The trouble with the people is that they don’t understand the proper use of power. Only those who occupy the corridors of power truly understand and appreciate it. Give the people power and the result is self-indulgence and licentiousness.
Thank God HillBill has all but been anointed by the Democratic Leadership Council (DLC), and thank God for the council and their heroic efforts to purge the party of its populist contagion. It’s dedications to centerism and triangulation has given us Iraq, Afghanistan, outsourcing and the economic meltdown that will prove a boon for the council’s corporate masters.
Between HillBill and the DLC you may be sure that when the convention rolls around it will make little difference how many delegates bamaobama has won in free and open elections. The party’s Super Delegates will obediently fall into line and make sure that America’s dynastic domination by corporate interests continues unabated.
Let HillBill prevail with her "solutions, solutions, solutions", the same sterile solutions that have brought America to the precipice of a new age of chronic disaster management.
With HillBill’s appointment, the GOP will snap to attention in a frenzy of rabid unity and John “Mad Dog” McCain will be swept into office and the beat will go on and on and on.
I think it’s time for the DLC to lean on the Senate to get S 1959, the “Violent Radicalization and Homegrown Terrorism Act” passed. This is the chemo that will shrink the populist tumor once and for all. America can’t afford another bamaobama.


On 18 September 2008, Jacinta Allan, the Victorian Minister for Regional Development opened Stage 1 of the Wangaratta High School project. Of particular interest was the Geoexchange system that has been installed to provide heating and cooling for the new building.
Rex Price, the Acting Principal of Wangaratta High School, believes the Geoexchange solution is the major piece in their energy efficiency strategy, which also includes passive design features such as appropriate building orientation, double glazing and insulation.
The Geoexchange system is expected to provide the required air conditioning for the school at 25 % to 50 % of the cost of a conventional air conditioning system.
The Geoexchange installation at Wangaratta High School was funded through the ‘Four Seasons Project’ administered by Regional Development Victoria.