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It is particularly exciting that the silencing of endothelial gene markers following a single dose persisted for two months. Since the duration of silencing is critically dependent on the cell type, for example its proliferation rate, this bodes very well for all delivery technologies targeting the vascular endothelium.
Alnylam mentions that the new LNPs (liposomal nanoparticles) that work for endothelial siRNA delivery stem from their collaboration with the MIT which as we know has involved positively charged ‘lipidoids’. Seen in light of the data by Silence (cationic lipid-siRNA)/Intradigm (RGD-targeted PEI polymers), the picture that is emerging is that LNPs that comprise positively charged lipids have a natural propensity of being taken up by vascular endothelial cells. Although I haven’t seen the details yet, it is to be expected that a number of parameters beyond positive charge, such as the method of formulating the particles, e.g. SNALP-like siRNA encapsulation versus Atuplex-like lipoplex formation, determine the efficiency of the functional uptake of these particles.
Beyond Alnylam and Silence Therapeutics, which with Atu-027 already has an endothelial cell-targeting RNAi Therapeutics in the clinic, Tekmira should also have considerable expertise in this area. Similar to optimizing LNP delivery to the liver, leadership in endothelial RNAi will depend on first empirically determining the structure-function relationships of these particles and then the biological pathway by which the uptake occurs. To my knowledge, it is still unclear whether receptor-mediated uptake, non-specific macropinocytosis ('cell drinking'), or the limited capacity of endothelial cells for phagocytosis is involved. This will also be important to understand as more targeted technologies will be developed.
One trade-off that current technologies might suffer from is that their positive charge at physiological pH may cause them to be slightly more toxic compared to negatively or neutrally charged formulations. This may also tie in with Phil Haworth’s comments in my last interview with him that Silence Therapeutics will initially focus on acute indications with high unmet needs. But again, everything is toxic at sufficiently high concentrations and it is encouraging that Atu-027 is still in its dose-escalating phase according to the last clinical update by the company.
Progress also reported for systemic RNAi delivery to immune cells
Following up on their declared pursuit of vaccine opportunities, Alnylam also highlighted progress in the systemic delivery of siRNAs to immune cells. Previously, LNPs comprising lipids derived from the KC2 series of next-generation ionizable lipids had been described to silence the immune cell marker CD45 with an ED50 of approximately 1mg/kg following intravenous administration (see RNAi delivery roundtable). The new report suggests some improvement over those formulations, stating that a 95% knockdown of CD45 was achieved, with an ED50 of as little as 0.2mg/kg. It will be very interesting to see the scientific details and discussions on these experiments (note: this last paragraph was corrected from an earlier version that mistakenly stated that the 95% knockdown was achieved with 0.2mg/kg).
Uptake of RNAi triggers by immune cells per se is not entirely new. It is a case of turning lemons into lemonades, as the non-specific uptake of nanoparticles by phagocytic cells has been long lamented. However, these cells play a central role in at least as many important diseases as endothelial cells do- so why not harness the efficient uptake of particulates in those cells for therapeutic purposes? Sure, being taken up and being functionally released into the cytoplasm are 2 separate issues, but Tekmira’s Ebola work has shown already that LNPs can trigger gene silencing in macrophages. Again, it will be important to delineate the functional uptake pathways and to employ chemistry to increase the efficiency with which LNPs can harness them.
Once thought of as liver-only formulations, LNPs are showing more and more their considerable versatility. I remember well a talk given by Tekmira’s CSO Ian MacLachlan at Stanford two years ago when he demonstrated that by even only slightly changing the formulation parameters, strikingly different patterns of biodistribution can be achieved. Now it ‘only’ takes one of the LNP/SNALP programs in the clinic to show some efficacy, and the pharmaceutical industry to change its approach towards drug target selection, for the liposome to finally shed its image as the unloved, but necessary stepchild of the industry.

domain: medical


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International centre to explore medical use of cannabis opens in Prague
A center for research into the use of cannabis in medicine has been opened in Prague. The International Centre for Cannabis and Cannabinoids Institute has been created with the help of 500 million crown donations from the US and Canada. Health minister Svatopluk Němeček said the sum represents the biggest foreign investment in Czech medicine in recent years. The centre has been tasked to explore the use of cannabis and its components both with regard to existing medical knowledge and the experiences of patients. Although legal for some conditions, Czech doctors are said to be still cautious about prescribing medicinal cannabis.


There’s been a lot of talk about, and tremendous interest in, Genesis Robotics because of its new invention, the LiveDrive, an actuation system which could not only revolutionise industrial robotics and automation, but could also transform automotive vehicles as well as change many other machines, devices and whole sectors.
But for the people behind the technology, one especially interesting potential application for LiveDrive is exoskeletons and what the company calls “assistive robots”, which they see as being in virtually every home in the future.
Company claims its LiveDrive actuator system offers “unparalleled performance”, and will replace traditional gears – and change the global robotics market forever
A well-funded startup called Genesis Robotics claims it has developed “breakthrough” technology which is set to change the global robotics market.
The vast majority of robots today use gears in their actuators and other parts. Gears – as an invention – are thousands of years old and have served industry and humanity well and will continue to do so, but Genesis claims it has developed a better solution, which it calls LiveDrive.
Genesis says traditional gears are slow, expensive and the way their teeth work creates something called “backlash” – like a rebound or bounceback as the teeth from different gears interact or collide, as well as friction. This inevitably leads to waste of energy.


- Press Release
- Oct 31, 2023
Saft Powers Successful Return to Earth for Stardust Probe
Batteries provided power to activate parachutes to enable a flawless landing
With its safe return powered by Saft’s lithium sulfur dioxide batteries, NASA’s $212 million Stardust spacecraft and capsule has been orbiting in space for nearly seven years and is anxiously awaited back home. Last weekend the spacecraft released its sample return capsule, which re-entered the Earth’s atmosphere with a safe landing in Utah. The capsule carried particles collected by Stardust as it passed through the coma (the halo of particles around the head of the comet) of Comet Wild 2 in January 2004. Stardust has now delivered to Earth the first samples ever collected from a comet.
The successful landing of the Stardust sample return capsule is due in part to the powerful Saft lithium sulfur dioxide batteries, which provided power to activate the mechanism that released the parachutes for landing. Then Saft’s batteries powered the signal for beaconing in order for NASA to locate the probe out in the desert.
“It is an honor to contribute Saft battery technology to this successful mission and we are excited to see how this new data will further our understanding of how the solar system formed,” said Saft America President and CEO, Dr. Khushrow Press. “What a tremendous accomplishment for the NASA space program and for Saft.”
The Stardust mission was launched from Cape Canaveral in February 1999 atop a Delta 2 rocket. Since then the spacecraft has flown 2.88 billion miles, circling the solar system three times and venturing farther from the sun (253 million miles) than any other solar-powered spacecraft.
Additionally, in the late winter and spring of 2000, and again in the late summer and fall of 2002, Stardust opened its collector and scooped up particles of interstellar dust drifting through the solar system.
Saft’s batteries were chosen for their unique performance, with minimal voltage delay – providing instantaneous power. Only Saft batteries could meet the challenging performance requirements of the Stardust, not only in terms of voltage delay, but also in terms of the robustness of the battery mechanically to maintain power for nearly seven years and guarantee a safe landing for the probe and its invaluable data.
The Stardust probe had two Saft batteries comprised of four SO2 D cells to power the probe for the landing and then the communication phase of the project. The lithium sulfur dioxide technology in these cells is of the same high performance used in many portable applications, such as the BA-5590 battery used to power military communications equipment.
“The contribution to the Stardust mission is an appropriate tribute to the Saft professionals who supported these missions in Cockeysville, MD, and at our manufacturing facility in Valdese, NC,” said Press.
Saft (Euronext: Saft) is a world specialist in the design and manufacture of high-tech batteries for industry. Saft batteries are used in high performance applications such as industrial infrastructure and processes, transportation, space and defense. Saft is the world’s leading manufacturer of nickel cadmium batteries for industrial applications and of primary lithium batteries for a wide range of end markets. The group is also the European leader for specialized advanced technologies for the defense and space industries. With approximately 4,000 employees worldwide, Saft is present in 17 countries. Its 16 manufacturing sites and extensive sales network enable the group to serve its customers worldwide.
For more information, visit Saft at www.saftbatteries.com


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domain: literature


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At CIS our mission is twofold, we are committed to providing world class consultation and support to our clients, as well as giving back to those less fortunate and their families. CIS has partnered with different charities over the years to help make a difference for those who need and deserve our assistance.
We Believe in Giving Back
At CIS we recognize the importance of caring and focus on organizations that are near and dear to our hearts, and truly help those in need. Throughout the year CIS collects donations, and in December CIS management matches the total staff raised donations for the chosen cause of the year!
We are proud to have partnered with:

domain: sociology


text:
Depression in teens is treated in the same way as depression in adults.
Often adolescents may also benefit from certain psychological therapies. These are effective in moderate to severe depressions when used complementary along with the medicines.
Research shows that it is possible to treat the depression in adolescents completely and effectively. However, parents and medical practitioners should take a note of the warning issued by FDA of USA regarding the increased risk of suicides from youths taking antidepressants like SSRIs.

domain: psychology


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Often mistaken as solely the "yoga of sex," Tantra Yoga is more accurately described as the "yoga of everything," in which the spiritual is united with every aspect of life. This book offers step-by-step instructions and illustrations to explain the practice and philosophy of Tantra Yoga — adapted to the specific physical, emotional, and spiritual concerns of women. The author explains differing methods of meditation and mantras, breathing and relaxation, yoga positions, visualization, and affirmations — demonstrating how a daily routine of meditation and yoga can bring focus and strength both physically and spiritually. More than a guide to fitness, A Woman's Guide to Tantra Yoga brilliantly adapts one of the most venerable Eastern practices to the demands of modern life.
About Vimala Schneider McClure
See more books from this Author
Published January 31, 2012
by New World Library.
Health, Fitness & Dieting.

domain: library


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With his second EP Romance Dawn II: One Piece set to drop August 3rd, Will Wildfire is giving the fans the opportunity to listen to the project exclusively. Come out to support and listen to the story behind each track. Most importantly socialize and network with other artists, designers and the people of Charlotte.
Information & Amenities
Age Range:Adults (18+)
Facility Amenities:Parking on site
General Information:Hours of Operation: 7pm
Type:Music & Concerts

domain: artistic


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Tuesday, April 17th, 2012
Even though the weather in Minnesota can’t seem to make up it’s mind if it should be a cool Spring or an early Summer, the itch to get outside is hard to resist this time of year.
Since the lilac trees are beginning to bloom (meaning the morel mushrooms will be popping up soon!), I’m going to start planning my summer outdoor decor now and remain optimistic that the warm weather will soon be here to stay.
So what items have caught my eye lately?
First I received this email from Crate and Barrel that heavily features this year’s accent color, Tangerine Tango.
Of course I’m digging the orange watering can and wishing for some orange cushions to liven up my standard stacking outdoor chairs we got at Target years ago. I also love the rustic style of the Driftwood Birdhouse as a foil for the modern boldness of the orange accents.
We already have 2 Emmet Lounge Chairs in green from Room and Board we got from a friend when he moved to San Francisco last summer. They’ve held up beautifully without any covers this winter, and they’ve been a great punch of color out the windows in the middle of the bleak winter. So how do I tie the orange and green together? Here are my inspiration boards showing the current state of the deck (it really doesn’t look like anything special in this photo) and my goal end results.
First off, what does this deck look like now? Well, the top left picture shows it in action the FIRST WEEKEND after we moved in. Our friend, Tom, was visiting for business so we had no time to wait before playing hosts. So what do you do? Send the guys off to golf, set up the patio furniture, grill a giant platter of veggies (foreground) and some steaks, open that giant bottle of Heineken beer you got as a gift, and enjoy the company of friends.
Now it’s a year later (almost) and our plans for the deck are pretty settled in our minds.
Step 1: Strip the red stain off the deck and flip/repair any damaged boards.
Step 2: Remove the existing railing.
Step 3: Remove the slanting and shallow depth steps to the yard. (They are tricky for kids and in the winter)
Step 4: Install longer, deeper steps in one location.
Step 5: Install new square posts along the perimeter.
Step 6: Stain the deck, posts and steps a warm gray color.
Step 7: Install a cable rail system around the deck for a more open and modern aesthetic.
Ok, you have that visual in mind now? Now here is how I’ll furnish the deck, utilizing the existing wood slat table and chairs (seen above).
First, I’ll use our existing umbrella that looks similar to the example above, though it’s in more of a narrow two tone gray stripe pattern.
Then pull the punch of orange I’m craving together with our green Emmet Lounge Chairs by mixing in throw pillows with large botanical prints in orange and green.
Though I’d love to buy the Layered Side Table in orange, it makes more sense in white when placed between the green chairs. I like that the width of this piece easily allows for both loungers to have a spot for their drink AND snacks.
The gray dining chairs will get a punch of orange with the striped throw pillows that pull together the gray colors of the house, deck and umbrella.
The deck, front entry, and garden will all get accessories of their own in the form of large gray planters, a new doormat (it’s a Fox!), stone lanterns along the paths for mood lighting, and sculptural pieces to tuck in amongst the plantings.
Finally, a deep orange watering can will inspire me to help with the gardening duties, which is key since my husband is planting a huge vegetable garden for the first time this year. I can’t wait for all that kale, tomatoes, cucumbers and fresh herbs to take over my kitchen!
Since the Fox doormat is sold out, I’ll be recreating this with the plain coir doormat I already have, a stencil and some paint. Easy peasy!
I can’t wait to get started on all these great projects (after I finish the nursery I’m working on now, of course.)
Ad from Crate & Barrel
Photo of my deck taken by me
13. Fox Doormat (no longer available)
Tags: cable railing, color palette, Crate & Barrel, deck, gray, orange, patio, pillows, planters, Room and Board, table, VivaTerra, West Elm
Posted in Design & Home Living Tips, Inspiration Boards | 2 Comments »
Thursday, July 29th, 2010
I found myself craving Oreo cookies the other day, which is unusual for me. It’s not my usual cookie of choice, but cravings must be satisfied or they take on a life of their own. While enjoying a couple of DoubleStuf Oreos and appreciating their simplicity, it struck me that they were a great inspiration for the quintessential color palette combination: black and white.
So here are some of my favorite black and white rooms. I tried to find spaces that only used those two colors. It’s interesting to see how often people choose these colors for their kitchens and bathrooms and how well these colors work in both traditional and contemporary rooms.
This palette works well in any room of the house, even outdoors.
Alexander Wang, a successful product designer/artist, who tragically lost his life earlier this year (in what some believe was the result of his sleep disorder), created playful spaces with a unique mix of textures and forms in his loft in NYC (upper right picture). I love the black trim around the windows in the upper right photo. It’s a trend that’s been emerging over the past couple of years and it can really change the feel of a space.
The white on black paneling on the lower right photo adds a great graphic element. Most people would be terrified to have black walls, so they have guts.
The desk at right is another Alexander Wang piece. What an office that would make! All the other rooms have dark walls, but all of the white trim, artwork, magazines and other design elements create balance to temper the darkness. The dining room at the bottom has classic bones and proportions, but mixing in the contemporary chairs and art hanging over the table keeps it young and fresh.
This final group showcases the power of wallpaper. The graphic nature of these wallcoverings adds instant personality to each room. The background in the dining room in the middle of the top row is actually a wall of patterned curtains with a valance above, but it creates the same type of effect with such a solid wall of pattern. Powder rooms is a great place to experiment with bold colors and patterns since we spend so little time in them and they are small enough that no pattern will seem to go on and on. My favorite room is the dining room with the wall covering of a forest in black and white. I love the juxtaposition of it with the traditional moldings and chair rail and the completely funky dripping chandelier off a natural branch style form. And the table settings in black are so minimal and modern. Brilliant mix.
I love color. But the restraint of a limited color palette can push you in new directions that can be a fun challenge. Remember to include a variety of textures and shiny and matte surfaces. The eye needs visual variety, and if it’s not through color, make sure it gets it through textures and different tones.
Could you live with even ONE black and white room? Which room would it be?

domain: hobby


MINNEAPOLIS — Community members came together in Minneapolis Saturday to support a push for more climate action in the city.
The circle was organized by Minneapolis locals. They’re hoping to see city leaders take-up a People’s Climate and Equity Plan.
It would expand existing climate goals — and oversee investments in clean energy.
It would also focus on the voices from communities of color.
The group says the goal is to make every building in the city more comfortable, affordable and carbon-free by 2030.
Source : https://www.cbsnews.com/minnesota/news/community-members-hold-climate-change-circle-to-push-for-more-city-action/


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Natural, beautiful and very abundant, are the wild Red Dogwood bushes. . . just over the hill from the RedBarn. Sure, we always need to use good sense when gathering designing materials from plants and trees. A little pruning done in a large growth area of the Red Dogwood really won’t hurt a thing. It’s a splendid way to add RED to your outdoor decor.
Anyone have good ideas for used twine? Although my “used twine bow” is a little understated among the Colorado Blue Spruce boughs swinging on the RedBarn, I’m happy about finding a use! Bet the twine would make a lovely basket or mat if I knew how to weave. Simple JOY in decorating the outdoors with simple goods on hand! Satisfying!
Sweet Hunter does double duty; he puts on his guard dog look while his real intent is to soak up the winter sun.


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EU The Spokesperson of Catherine Ashton, High Representative of the Union for Foreign Affairs and Security Policy and Vice-President of the Commission, issued the following statement on Friday:
“The High Representative deeply regrets the appointment of Admiral José Américo Bubu Na Tchuto as Navy Chief.
Mr Bubu Na Tchuto played a destabilizing role in the aftermath of the 01 April mutiny and is under sanctions by international partners for alleged links to illicit activities.
This decision constitutes a further setback to good governance in Guinea Bissau, shows a further militarization of politics in the country, and could entail negative consequences in the country’s relationship with the EU as it engages in a review of its overall engagement with Guinea Bissau. The EU reiterates the paramount importance of military respect for civilian institutions and the rule of law, and reiterates the incompatibility of anti-constitutional behaviour or involvement in illicit traffics with such positions of responsibility.”
Post your comments

domain: law


After being cancelled in 2020 due to the COVID-19 pandemic, the Splash Fen Music Festival is set to make a big and bold return in 2022.
One of the world’s most treasured groups, the Ndlovu Youth Choir are set to perform at the Miss SA pageant on Saturday 16 October.
As South Africans participate in Mandela Day and offer 67-minutes of service, the Ndlovu Youth Choir have provided a soundtrack.
The Ndlovu Youth Choir released a new video in which they sing for peace in South Africa amid ongoing riots and looting.
South Africans will love the Ndlovu Youth Choir’s version of Lady Gaga’s ‘Shallow’ from the film ‘A Star Is Born’.
Master KG and the Ndlovu Youth Choir’s Africa Rising performance on Robben Island clocked in one million views during its global live stream.
On Sunday 25 April, ‘Jerusalema’ hitmaker Master KG and the Ndlovu Youth Choir will be performing live on Robben Island for Africa Rising and the Live Love non-profit organisation
Master KG and the Ndlovu Youth Choir: Two of South Africa’s most famous acts are teaming for a special performance this coming April.
The Ndlovu Youth Choir recently released a song titled ‘Jaba Jaba’ to help encourage and motivate South Africans to get vaccinated against COVID-19.
South Africans will love the Ndlovu Youth Choir’s version of Mariah Carey’s ‘All I Want For Christmas is You’.
Pink and the Ndlovu Youth Choir performed ‘A Million Dreams’ at an exclusive virtual fundraiser for UNICEF.


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Is there any legal recourse for being dropped for nothing other than making a few legitimate claims over 12 years?
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Insurance Question from Springfield, MO
Asked on 07/01/2014
Is there any legal recourse for being dropped for nothing other than making a few legitimate claims over 12 years? The reason this matters is one, my agent says he's never seen anyone dropped for these types of claims at such low amounts, and two, now I'm looking at a deductible three times what I'm getting now. They refuse to talk to me. I was never made aware of these conditions when I signed up for the policy. I want to be compensated for this mess.
Answer given on July 30, 2014
Each insurance company has its own standards for maintaining insurance coverage for its clients.Even though you have been a client for 12 years with the same insurance company, it appears that you have had multiple claims. This alone can cause an insurance company to non renew your policy. You indicate the claims are of low amounts. This too raises a red flag with the insurance company and causes concern that you file a claim for small amounts. While insurance covers these claims, the insurance company looks upon them as nuisance claims. Your insurance company may withdraw the non renewal of the policy if you agree to a higher deductible. They will feel that there will not continue to be small claims filed with the higher deductible.Your insurance agent should have consulted with you over the years as you filed these smaller claims. They should have known that a history of claims like those would draw the attention of the insurance company. While your agent cannot tell you not to report a claim, they can advise you on the pros and cons of doing so.
IMPORTANT NOTICE: These answers are for general information purposes only and are provided by the person answering and FreeAdvice.com AS IS. It has not necessarily been reviewed by the management staff of FreeAdvice.com nor is it binding any insurance agent, broker, or other insurance professional or any attorney or insurance company. Insurance laws, regulations and practices vary from state to state and insurance policies and practices differ from company to company, by type of policy, by state and locality and by type of insurance. Tiny variations in the facts, policy language or a detail not set forth in a question often can change the outcome or a professional's conclusion. Although FreeAdvice.com has confirmed that the answer(s) was/were provided for the account of an experienced insurance professional, that professional may not be licensed in the state referred to in the question, and may not be experienced or up to date in the subject area. Unlike the answers provided here, upon which you should NOT rely, for personal advice you can rely upon we suggest you consult a licensed insurance professional in your area or retain a licensed attorney listed on AttorneyPages.com to represent you.

domain: finance


KBC Home→ Why KBC?
Whether comfortably transporting a broker from Washington D.C. to New York City’s Penn Station on Amtrak’s 135 mph, 100 ton Acela locomotive within three hours, or perhaps carrying a mother and child to Museum Station on Toronto, Ontario’s brand new 1,100 passenger “Rocket” subway train, one thing is certain: they must stop consistently, predictably, and comfortably, all at an astronomical frequency. At KBC, our employees ensure that our friction systems — both friction and magnetic — on locomotives, subways, and light rails come to a halt so efficiently and safely that they’re nearly transparent to the passenger. Try accomplishing that in a traffic jam-laden commute to your favorite metropolitan area — the ensuing headaches will be sure to make you consider rail transit for the next commute. Our automatic passenger doors through IFE and HVAC systems through MERAK provide the transit authority’s customers with the highest standard of comfort, transparency of use, and safety.
With the accruing residential and governmental support of future “green” high-speed and local rail transit projects, the need for individuals ready to help solve these engineering problems comes to face: your help is needed! In the past decade, Amtrak alone saw an increase of 37% in ridership with 28.7 million passengers (its highest level ever) in 2010 alone, and is forecasted to grow steadily. Continuing government appropriations to repair and improve infrastructure and railways in the US support the data.
KBC is part of a global network spanning 26 countries that helps provide congestion- and emission-reducing passenger rail transit solutions: these networks certainly aren’t going to build themselves. Knorr-Bremse commits five percent of its revenues to research and development of these new technologies, and KBC is a proud part of this change.


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Doubt if anyone remembers me, it's been absolutely ages since I last was here.
Used to make models for UT back in 99 and 2000 I think and was around here a lot, trying to absorb some knowledge and insight.
I wasn't any good at it but I had fun and learned a lot.
I stopped, and eventually faded from the Polycount boards.
A good while back I started on a hobby project that requires I model a bit.
That means I need to bush up, a lot.
Started that a few months ago and just now remembered good old Polycount.
I see a lot has changed, the board seems to have become more industry focused than it allready was.
As such I have no idea if there is still a place here for hobbyists like me, or even if placing introductory posts is still considered appropriate.
But if there is, I'm back and I'll be posting WIP's and begging for advice just like I used to do in no time flat
(found my old sig, will post it this once to hopefully jog some memories, images can do that


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Controlled by CITY COUNCIL
Transmitting a bill authorizing transfers in appropriations for Fiscal Year 2016 from the General Fund, the Department of Revenue, the Board of Trustees of the Free Library of Philadelphia, the Commission on Human Relations and the Grants Revenue Fund, the Director of Finance - Provision for Other Grants to the General Fund, the Mayor - Office of Community Empowerment and Opportunity, the Managing Director - Legal Services, the Department of Revenue, the Director of Commerce, the Law Department, the Board of Trustees of the Free Library of Philadelphia and the Commission on Human Relations.
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Status: PLACED ON FILE


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The Kitezh region is a picturesque and an area filled with legends. “There Russia is still pure, it’s preserved now the way it was in our grandparents’ time,” – this is what Russian writer Pavel Melnikov wrote about Zavolzhye (literary: “the Trans-Volga Region”). One of the pearls in the Northern Zavolzhye is the mysterious lake Svetloyar. Legends say that it is hiding the ancient town Kitezh under its waters. The lake is located at the edge of Vladimirskoye village, 130 km from Nizhny Novgorod.
Vladimirskoye village in the Voskresensky district has acquired the status of a historical settlement due to its great cultural and natural heritage.
Approaching the village center, one can have a beautiful view over a wooden architecture monument – Church of Our Lady of Vladimir that gave its name to the village.
The church was constructed in 1766, but its appearance, inner decoration and a very special atmosphere have preserved until now.
Having bowed to ancient holy places, let’s continue our way to Kitezh Museum of History and Arts. Here one can dive into the world of vivid legends and stories about the hidden town of Kitezh. The visitors here can also learn plenty of interesting facts about the history of the Svetloyar lake origins, the famous people that have visited the legendary lake and left numerous works of art devoted to Svetloyar and Kitezh.
Next to the museum there is a children ethno-cultural center “Kitezh” in a beautiful wooden mansion. A number of studios – floristics, ceramics, weaving and embroidery, wood carving – as well as exhibition halls are ready to show the creative work of talented young students that make the legends come back to life in their works.
The picturesque and mysterious Svetloyar lake is located at the edge of the Vladimirskoye village.
There are numerous poetic legends and stories related to the lake. It’s quite often called a “sublime miracle” because of its origin, supposedly connected to a meteorite fall. But the lake is a piece of historical and cultural heritage as well as a natural one. Svetloyar is a special place, it’s worshiped by the Orthodox including Old Believers. One of the most poetic and mystical legends describes its history: “When Batu Khan Mongol troops approached the town of Great Kitezh very closely, godly monks turned in their pray to Our Lady pleading her for help. All of a sudden the suffering people were lit with Divine light. Mother of God descended from the heaven holding a miraculous cover which hid the town of Kitezh”. The legend about Kitezh was the source of inspiration for the famous opera by N.A. Rimsky-Korsakov “The Legend of the Invisible City of Kitezh and the Maiden Fevroniya” and for many paintings (canvases by Glazunov, Vasnetsov, Roerich, Korovin). The writer P.I. Melnikov-Pechyorsky also paid his tribute to Kitezh: “The town is still safe but invisible… It was concealed miraculously by a divine order… On the surface of the Svetloyar lake on a calm Summer evening one can see walls, churches, monasteries, prince’s palaces reflected in the water… And at nighttime one can hear the Kitezh bells ringing…”
The museum-tourist complex “Grad Kitezh” has been opened in 2015, it consists of the following: the theatre, where it is planned to stage the performances as per the plot of the legend about grad Kitezh with a peculiar animation accompanying and where even now there are guest performances of Nizhni Novgorod theatres; exhibition areas to show works of painters, masters-craftsmen and etc. Moreover, the museum-tourist complex “Grad Kitezh” is the excellent area to carry out interactive programs of various topics, development of event and business tourism.

domain: geography


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DEARBORN (WKZO) -- Triple A of Michigan no sooner released their weekly survey of gas prices in the state, than suddenly those prices started rising again, for the second time in a week.
It prompted Nancy Cain at AAA to try to find out why they were suddenly on the rise. She says it appears to have been due to refinery issues.
Cain thinks it will be short lived for that reason.
She says its been tougher to gather information lately because a lot of it comes from the Energy Information Agency, which is run by the U.S. Government, and it's shut down.
She says it appears to be a refinery near Toledo area that is having issues.

domain: economics


text:
If you dream it, you can do it!
Justin Time: The Pancake Express
Adapted and illustrated by Brandon Scott
$15.95, hardcover, 36 Pages,
ISBN: 978-1-59702-035-0, 10 x 9.75
"Broadcasters currently airing the hit series include Discovery Kids (Latin America), Disney Junior (Australia, New Zealand, Germany, Italy and French-speaking Canada), YLE (Finland) and HOP! Channel (Israel)." - Kidscreen
This debut book series is based on episodes from the popular animated television show, which airs on PBS Sprout and NBC Kids on Saturday mornings in the USA, and on Disney's Family Channel in Canada.
All aboard! Justin and his pal Squidgy imagine themselves behind the wheel of a classic steam train, delivering important cargo for their friend Olive.
But they discover it's not easy getting through the Canadian wilderness. Will their barrel of maple syrup make it to Flap Jack Falls in time for the Pancake Festival? Never give up!
Justin Time is broadcast on Disney Junior channels in Australia, New Zealand, Germany, and Italy. Also it is seen on Discovery Kids (Latin America) and Discovery Familia (USA) and in United Kingdom, Finland, Israel, South Korea, Estonia, Belgium, and Germany.
Order your autographed copy
International readers - please note: non-USA addresses need additional postage. Click here to add the appropriate amount to your shopping cart before you check out. Thank you!
More praise for Justin Time
"4 stars [highest rating]: It is refreshing to see a new series for this age group featuring a male character and with a focus on imagination and education. [The Pancake Express] contains accurate scientific and geographic information, but it is presented as part of the adventure...Highly recommended."
- CM Magazine
"Remember as a kid when possibilities seemed endless and a cardboard box could transform into a fort, a tank, a mountain, or a Super Mario pipe?… Justin Time is a new animated program for pre-schoolers that brings that boundless creativity to the small screen. The show centers on Justin, a young boy who imagines himself traveling around the world at different points in history."
"Tired of preschool cartoons spending an inordinate amount of time on boring matching games, talking down its audience, or afraid of going out on a creative limb? If so, then meet Justin Time...The series is about trust and teamwork -whether nestled deep in the jungle or perched high on top of a snowcapped mountain - and the many other elements of friendship most conducive to having a great time (and learning a thing or two along the way). Justin Time encourages a kind of freewheeling imagination that hopes to leave the didactic and lazy storytelling of yester-animation in the dust."
- Animation Insider
Enjoy the YouTube preview!
"Justin Time features a young boy named Justin, who embarks on imaginary adventures with his make-believe friends Squidgy, a shape-shifting piece of yellow clay; and Olive, the group's trusty navigator and guide. Together, the intrepid, high-spirited trio takes off on bite-size historical adventures."
- Animation Magazine
"Justin Time is a fantastic new addition to Sprout's line-up of gold-standard programming expertly tailored for the preschool audience. Justin's exploration of the world through historical adventures encourages parents to talk with their preschoolers about the parts of history they learned during the episode while promoting an appreciation for the subject matter."
- Andrew Beecham, senior vice president of programming, Sprout
PBS Sprout News
Lexile Level: 570L
Lexile Code: AD "adult directed"
Fountas & Pinnel (F&P GRL): J
GLE (Grade Level): 1
Interest Level: Pre K-3
Reading Recovery Level (RRL): 17
Accelerated Reader: Lower Grades
- ATOS Book Level: 2.8
- AR Points: 0.5
- AR Quiz Types: RP

domain: entertainment


text:
Drifters Apartel And British Bar
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... one reef in and that makes their boat roughly the same speed as ours. This works well for us to stay in company in transit, which would become even more important as we worked our way north towards Davao, as events were about to take a sinister turn in the Southern Philippines.
We made two more stops at the intervening islands before arriving at a beautiful atoll called Siau. Our intermediate stops were lovely but the winds and currents and generally poor holding prevented us ...
Friday Ed and Daniel Macareag took me to see Jed Sy and her brother Jong Pilapil. The two prisons are located about an hour out of Davao. The prison guards and inmates all know the two prisoners, who being model inmates in their respective institutions have risen to status that can only be categorized as Joseph like. Still trapped in the compound, they both none the less have been given accommodations and work in the prisons.
The guards have ...
From here we drove back through heavier Friday afternoon traffic to the hotel. Jeepnies, the public transportation of the Philipines are in abundance on the roads. After World War II, Americans left behind thousands of jeeps that became used as public transportation. They became modified as litle buses. The appearnace stuck and now the power train ironically is produced in Japan while Filipino firms ...
... along side the horse carrying Chell, enjoying the scenery around us and breathing the smell of volcanic ash, nauseating but still addictive.
Our 2 day combo package ended, with Don dropping us off in Microtel after beating the heavy evening traffic in Manila city.
We had planned to keep the day simple, and hired Jon-Jon for our cab, who to our surprise, turned out to be father of 19yr and 16 yr girls, while he himself looked only 19.. very young ...
... located at Sitio Bato in Santa Cruz, this man-made paradise was used before as a base for the coast guard and can be accessed by a 500-meter long wooden footbridge. This once secret hide away has crystal clear turquoise water and pristine white beaches; a barefoot walk on the soft sand will you the best relaxation experience you have ever had. The place is a pleasing hang-out for local beach goers and tourists and is considered to be one of the top tourist spots in ...

domain: travel


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Several area home improvement contractors received Contractor of the Year awards presented by the National Association of the Remodeling Industry (NARI) Washington, D.C. Chapter.
Contractors from the region vie for the awards on an annual basis. Judging is based on problem solving, functionality, aesthetics, craftsmanship, innovation, degree of difficulty and entry presentation.
For more information on the region’s NARI contractors, go to: www.narimetrodc.org.
Here are a few of the award-winning projects.


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Living room, Captivating Sofa Design For Contemporary Living Room Grey Sofa In Cream Living Room With Black Arch Lamp Modern Living Room Furniture Sets For Sale Modern Living Room Furniture Italian: Perfect modern living room sets
Published at February 06th, 2017 04:23:10 AM by Kristopher B. Schiff
Tagged as modern table lamp area of interest and The Best Modern Living Room Sets area of interest along with modern living room sets houston stores object, design living room furniture uk object or modern leather sectional sofa object, Impressive Modern Living Room Furniture Set topic along with Living room, So don't forget to check out the main article in Perfect modern living room sets
© 2018 Living Room Design. Reproduction without explicit permission is prohibited. All Rights Reserved.

domain: design


text:
By Michael Stewart, Assistant Sports Editor (Courtesy Photo/Bison Athletics)
The Oklahoma Baptist men’s basketball team has endured a difficult start to the new year.
After ending 2017 on a three-game winning streak, the Bison have hit a bit of a rough patch. Since returning from winter break, the Bison have a record of 4-8 pushing them to 9-13 overall on the season.
“We have definitely let some games go that we should’ve won,” freshman Laef Payne said. “We have a lot of talent on this team that can help get our season back on the right track.”
Despite the recent skid, the Bison are still well in position to earn a spot in the Great American Conference post-season tournament and have a shot at a title.
“I feel like we still have a chance to grab the eighth seed,” senior Travon Moore said. “We need to take it a game at a time and try our best to win the last six games of our regular season.”
The Bison currently sit at tenth place in the conference standings and are two games out of the eighth seed.
One thing that will play a key role in the Bison’s playoff push is protecting the rim and paint.
“Something that has continued to improve for us is our defense,” Moore said.
“Recently, we have been doing a better job of grinding out plays and getting stops.”
The Bison currently have the second most blocks in the GAC with a total of 105 so far this season. Senior Chandler Rickey has been responsible for 62 of those blocks.
Another key to the Bison’s success is their protection of the ball.
The Bison are ranked 3rd in the league in their assists per turnover ratio at 1.3. Lastly, the Bison must continue to shoot the ball efficiently from three.
OBU is ranked third in the GAC in three-point field goals made with 212 on the season.
“This team has high expectations,” Payne said. “We are expecting nothing less than to make into the top eight for the regional tournament, and to go all the way to win the national title.”
The Bison believe they have all the pieces to do so as well as the confidence to do so.
The Bison continue their chase for the post-season this Thursday, February 15 as they welcome Northwestern Oklahoma State University to the Noble Complex and again on Saturday at Southeastern.
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domain: news


The Securities and Exchange Commission (SEC) has written to gold-trading firm, Menzgold Ghana Company, to stop forthwith, all investment trading in gold without licence.
In the 3 September 2018 letter signed by Deputy Director General, Paul Ababio, the SEC said: “In September 2017, the SEC issued a public notice indicating that it does not regulate Menzgold. The SEC began further investigations into the activities of Menzgold in July 2018. In August 2018, the Commission called for an inter-sectoral meeting that involved the Minerals Commission, Bank of Ghana and the Securities and Exchange Commission. The Meeting concluded that it is evident Menzgold’s activities appear to go beyond the mandate authorised in its licence”.
The SEC said: “It is our expectation that being your licencee, MINCOM, would call Menzgold to order and direct it to conduct its business in accordance with the licence issued to it by MINCOM”.
It follows several warnings from the Bank of Ghana to the local gold firm, to stop trading in gold without licence.
The central bank, on 7 August 2018, issued a public notice, the fourth of many, that it was in discussions with relevant regulatory authorities to sanction Menzgold for engaging in “solicitation, receipt of money or investment and the payment of dividends or returns to its clients” without a licence to do so.


out for a ride ......made it about 8 miles and noticed a thumping or some thing strange under me.
I stopped and couldnt sort it out. I decided to turn around and head back. It thumped all the way home. Upon closer inspection the entire rim cracked in half
I remember hitting a pot hole but didnt think it was that hard. Wholey crap...they have been great riims too. Not a single issue....now i need a new back rim. THere is a flat spot and right where the flat spot is you can see a stress fracture in the aluminum and the spoke right in front of that area is super loose.
I ordered them about a year ago for BWW and have been 100% fully satisfied on the quality of the wheels. They are fantasitc. Ive contacted them to see if they will tear the down and slap a new rim on them for me.
well the good news is the folks at BWW are going to replace the rim for the cost of shipping. Thats good service right there. Ive bought 2 sets of wheels from them in the past and when i need more im doing business with them again for sure!


We are being told by our security team that the firewall of all things is reporting that a sharepoint file is infected with a virus. The file name is just Workbook.xml, and that's all that they have. We've searched the SP system for that file name and can't find anything, so we are assuming that it's embedded somewhere in a spreadsheet.
Does anyone know of a way to search for an embedded XML file within a spreadsheet? I was trying to find a powershell command that would do that, but am coming up short.


Product DescriptionAir Conditioning Suction Line for 1996-1998 4.6L Mustangs.
This line runs from the air conditioning accumulator to the compressor. Replace your worn out or damaged original Mustang air conditioning suction line with this OE stock replacement reproduction line. Quality craftsmanship.
Similar Mustang PartsMore Mustang A/C Components
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text:
Hello folks , our most recent coloringpicture which you couldwork with is Rubber Ducky Laughing Coloring Page, listed on Rubber Duckycategory. This particullar coloring picture height & width is about 600 pixel x 774 pixel with approximate file size for around 34.81 Kilobytes.
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Escort MPA-A 12g Semi-Auto 349.99;escort slug auto divdiv.
Escort Slug Auto, escort Slug Auto.
Glossy finish receiver barrel.
Checkered ventilated anti-glare raised rib with Hiviz Spark front sight fitted.Hatsan Escort Slug Combo.Escort Aimguard.Escort MPA-Camo.Hatsan has become one of the leading firearm manufacturers in North America for its well reputable durability, value, and products.It can safely fire all 2 - 70mm, 3- 76mm 3 - 89mm shot shells from 24 gr (7/8 oz) light loads to 66 gr (2 3/8 oz) heavy load double magnum shells.The new Hatsan XtremeMax offers Flawless performance on all 12 gauge shot shells.Other features of the hatsan Escort Raider semi-automatic shotgun.Hatsan Shotguns strada prostitute bolzano are a staple in every hunters.Oxidation Proof - Chrome plated barrels made of Chromium, Nickel, Molybdenum steel.22 slug barrel with welded cantilever for 22 mm scope mounts and 26 raised rib barrel with.Such slug shooting security/law enforcement shotguns are usually.Shotgun Barrels, Replacement OEM Shotgun Barrels - Great Prices, Great SelectionFeb 28, 2013 Looking at a new Escort semi-auto youth gun for my 14 year old, priced at 319 at a local gun store.Hatsan Escort Lady Series Pump this installment, we take a look at Legacy Sports rugged and affordable Escort line of shotguns.Escort Slug Auto Combo.Distributed by the Edgar Brothers, the incredible design and high quality manufacturing of Hatsan shotguns, rifles, and airguns has garnered the attention of hunters and sportsmen from around the world.Gray, right, edgar-XM410435mobulh, escort XtremeMax 12/30".5" Synthetic mobu LH 12 30 mOBU Left edgar-XM410335mobui Escort XtremeMax 12/28".5" Synthetic mobu Infinity 12 Gauge 28" mobu Right edgar-XM410335mobu Escort XtremeMax 12/28".5" Synthetic mobu 12 Gauge 28" mobu Right edgar-XM410335mobulh Escort XtremeMax 12/28".5" Synthetic.Semi-Auto; 12G Slug or Shot;.Escort, sEMI autos, escort, pUMP actions, escort Xtreme.Ni-Cr-Mo steel Slug barrels.Accessory magazine extension tube increasing capacity.All barrels are Proof Tested.
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Daily Record photo by Toy Mendez
San Marcos sees decrease in sales tax allocation
San Marcos saw a nearly 40% sales tax allocation decrease in June compared to last year.
State Comptroller Glenn Hegar distributed $907.6 million in local sales tax allocations for June to cities, counties, transit systems and special purpose tax districts. The comptroller’s office stated that this was a 31.5% statewide increase compared to June 2020.
San Marcos received a sales tax payment of $2,730,852.89 this period — a 36.48% decrease compared to last June when it received a payment of $4,299,578.95.
While San Marcos saw a decrease compared to last year, most municipalities in Hays County saw an increase in their respective allocations.
Kyle received a payment of $1,041,879.82, which was up slightly over 35% from 2020, when it received $769,765.52 from the state. Buda saw an allocation of $852,153.73 — a 30.4% increase from last June.
Dripping Springs was paid $322,931.85, which was up 21.56% from last year.
Uhland saw the largest allocation increase with a 104.9% jump from this time last year. Uhland received an allocation of $56,006.21 compared to last June’s $27,332.71.
Wimberley received a payment of $103,888.15 — a 34.76% increase from last year.
Niederwald was paid $6,624.22 — an increase of 20.89% compared to the prior year.
Woodcreek saw an increase of 4.76% after it was allocated $6,987.08 this June.
The City of Hays received a payment of $1,518.23, which was a decrease of 40.66% from June 2020. Mountain City was allocated $2,214.94 — a 41.88% decrease compared to last June.
June's allocations are based on sales made in April by businesses that report tax monthly, Hegar's office said.


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Mining is at the heart of Mount Isa – this is one of the top 10 producers of copper, silver, lead and zinc. Their caravan park accommodation at Discovery Parks – Argylla, (formerly known as Big4 Discovery Parks – Argylla), is just over one hour’s drive from Cloncurry and a great place to relax after your day of adventures.
Take the Underground Mining Experience for a guided tour 15 metres underground. Spend a day (or two) at Outback Mount Isa, including the fascinating Riversleigh Fossil Centre. Spectacular Lake Moondarra offers swimming, boating, sailing, canoeing and excellent barramundi fishing. Held every August, the Mount Isa Rodeo is the biggest event of its kind in the Southern Hemisphere and an absolute must-see.
The park is perfect for the stop over, take a dip in the pool or just relax poolside reading a book. The park has great wi-fi offered complimentary which you can use to update socials with your trip in the outback.
ActivitiesBirdwatching Camping Swimming Walks
Disabled AssistanceDisabled access available
MembershipCaravan Industry Association of Australia G’day Rewards
AccreditationAustralian Tourism Accreditation Caravan Holiday Parks Accreditation Program COVID Clean Practicing Business COVID Safe
Sites from as little as AUD35 to Standard Cabins starting at AUD99.
Check In: 2:00 pm
Check Out: 10:00 am


text: "The Lover's Quarrel" by Raksasa Master Carver Dewa K, is the legendary tale of Barong & Rangda. In Bali, Barong is the most powerful warrior of white magic, often seen in a wood Carving above the entry of a Balinese home serving as a guardian of sacred spaces. Rangda is the queen of darkness, using her powerful black magic to serve justice to the evil and corrupt. As a couple, they represent the fundamental unity of black and white forces. The famous Barong Dance of Bali tells the tale of Barong clashing with Rangda, where good conquers bad with Barong as the hero. However, further study of this tale one can find deeper wisdom in the infinite loop of tension as a source of growth and evolution of the soul on the path to enlightenment. Each challenge with face is a test of our ability to grow stronger in our Sakti powers. While the classic story of battle between opposing Gods highlights the infinite potential of self and communal growth towards higher consciousness, Barong & Rangda become lovers again soon after their quarrel. Their love for each becomes stronger with every conflict. No matter how crazy or angry we become in a quarrel, we hold just as much strength in love & forgiveness. Ignite your spirit with Raksasa Mods.


Which way do car batteries go in?
Place the new battery in the battery hold-down tray and secure the battery with the hold-down clamp. Spray both terminal ends with anti-corrosion solution. Attach and tighten the positive battery cable (Red). Attach and tighten the negative battery cable (Black).
Can a car battery go upside down?
the battery will fail over time if not immediately. Remember that most batteries are sealed so replacing the missing electrolyte is impossible. If it is a sealed battery nothing. If it has removable caps that are vented for filling it will slowly loose acid the longer it is upside down the more it will loose.
Are all car batteries positive and negative on the same side?
Fortunately, most batteries also have a plus (+) and minus (-) sign stamped into the case. As you might guess, the plus sign indicates the positive battery terminal, while the minus sign indicates the negative battery terminal. Most batteries also have a positive and negative sign stamped into the case.
Are all car batteries positive on left?
Each battery has two metal terminals. One is marked positive (+), the other negative (-). There are also positive and negative cables in the jumper cable set. The red one is positive (+), the black one is negative (-).
Which side of the battery goes on the spring?
Assuming you’re talking about round-type (cylindrical) batteries, such as D, AA and AAA, it’s to ensure maximum contact with the flat end of the battery, which is the “negative” terminal as described in the ANSI standard. You’ll commonly see leaf-spring contacts as well as coils.
Which side of the battery symbol is positive?
The two lines are on the far top and far bottom of the battery symbol, or on the far left and the far right. One line is longer and the other line is the shortest of them all. The longest top or end line is the positive (+) terminal of the battery and the shortest line is the negative (-) terminal of the battery.
Is it OK to tilt a car battery?
Electrons need to stand up straight. Tipping them over tends to make them sleepy and lose their charge. Never do this. Just remember the old Duracell batteries: the copper top.
What happens if a car battery is on its side?
As very few cars of that age used gel batteries and yours is most likely a lead / acid battery putting it on its side or upside down will cause acid to leak out. Not a good idea as it corrodes or damages most things.
What happens if a car battery falls on its side?
Batteries that have been dropped may not show damage to the steel case, but if a corner or side of the case is pushed in, cell damage is likely since there is usually little or no clearance between the steel case and the cells themselves. … Sparks from any of these operations can cause a battery explosion.
Is positive terminal on left or right?
Some batteries sizes are available with terminals in many different configurations, but two main configurations are: positive on left and negative on the right corner. negative on the left and positive on the right corner.
How do you hook up a battery to a car?
“Positive first, then negative. When disconnecting the cables from the old battery, disconnect the negative first, then the positive. Connect the new battery in the reverse order, positive then negative.”
How do you know which side is positive and negative on a car battery?
Car battery terminals will be marked and color-coded. The color red and the plus sign for the positive terminal and the color black and the minus sign for the negative terminal. The negative terminal connects to the vehicle’s metal chassis.


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Learn how to create a messy, Boho style ponytail with plenty of volume. Using a simple back-combing technique with a Mason Pearson brush, an elastic band, and Kirby Grips, Tina Farey will show you exactly how to create this simple, stylish updo.
With "My Queue" you can quickly save videos to watch later.
To add an item to your queue just click the sign next to the video.
Once you've added a video visit "My Queue" to start watching!


text:
Big second inning powers Abilene High softball; Wylie walks off against Randall
It was a long trip to Abilene for nothing.
Not that we are inhospitable out west. It's just that the Lady Eagles have Kaylen Washington in the circle, and some big bats at the plate.
After losing 23-0 in Game 1 of a best-of-three bi-district series Thursday, Arlington High made the 166-mile trip west hoping to put the scoreboard to better use. That didn't happen, as Abilene High swept with an 18-0 win on a windy, warm afternoon at the AHS field.
The victory moves the No. 3 Lady Eagles, 25-1-2, to the second round of the Class 6A playoffs. They'll play the winner of the Odessa-El Paso Franklin series. Odessa won Game 1, also Thursday.
AHS took a 1-0 lead after an inning, then poured it on in the second, scoring 15 runs. Coach Jim Reese, who got a bucket-drenching courtesy of Washington and Aubrianna Salazar after the game, said his team will be ready for tougher competition.
"This is a good team. They're good at raising their level of play," he said. "They'll be ready."
The first nine batters in the second reached base, with third baseman Salazar poking a three-run homer to left, leadoff hitter K.K. Roberson driving in three with an inside-the-park home run, and Alyssa Washington making it 16-0 with a two-run shot. Abilene High took advantage of the wind blowing out to left.
Roberson popped her pitch to center, but as the ball headed toward the fence, Arlington center-fielder Nia Newcome ran in. The ball sailed over her head and rolled to the fence. But the time she got to it, Roberson was rounding second.
"I always run fast," she said. "Run fast and turn left."
Roberson said her team was intent on dispatching the the Colts as quickly as possible.
"We don't let up, she said. "We are very confident and working very hard."
Pitcher Kaylen Washington almost had the day off, though she threw a lot of pitches to the first batter, Newsome. But it was 1-2-3 in the first, and the same in the second, with four strikeouts.
Salazar pitched two innings, followed by Mattie Perez. Brooke Kolanek's rolling single past first baseman against Salazar was Arlington's only hit.
"It's great to know we've got three pitchers for a long series," Reese said.
Other big hits for Abilene in the second were a two-run double by Hannah Lopez and a two-RBI single by Breana Berajas. Total, the Eagles had 15 runs on 13 hits in the inning.
Arlington (9-18 and the fourth place team in 4-6A) again went with Kylea Smith in the circle. She surrendered all 41 runs to Abilene High in two games.
Wylie cashes in on Buck's 3-run blast
At Woodrow, after outscoring Canyon Randal 17-11 on Friday, the Wylie bats had a harder time in the second game of their Class 5A bi-district series.
But they came alive in the bottom of the seventh inning. Big time.
Down 4-3, Kaylee Philipp singled, Halle Arbilera doubled and Bailey Buck slammed her second home run in two games to walked it off for Wylie.
"We knew it as soon as she hit it," Wylie coach Heather Collier said, adding her team had a walk-off win in district for a run-rule win.
"This was bigger," she said. "She nailed it."
Wylie (15-14) now plays El Paso Eastwood in the second round. Eastwood topped El Burges 6-3 in a one-game playoff.
In Game 1, Wylie led big before Randall scored eight runs in the fourth inning to tie the game at 11. Wylie then scored six times the final two innings to pull away.
"This was a hard-fought game," Collier said. "The first game had lots of hitting — we hit three home runs — but today both teams fought hard."
Philipp pitched the first 5⅓ innings, with Buck finishing. Combined, they allowed six hits and struck out 10.
Randall led four times but each one-run lead was answered by Wylie. Randall scored in the top of the first, fourth, sixth and seventh innings to take the lead but each time, Wylie answered with a run of its own in the bottom of the inning.
Molly Mason had two hits, as did Philipp and Buck for Wylie.
Randall finished its season at 19-16.
Monterey closes out Cooper
At Snyder, the Abilene Cooper softball team bowed out of the Class 5A playoffs with an 11-4 Game 2 loss Saturday to Lubbock Monterey.
The Lady Cougars (13-18-3) dropped a tough 7-6 decision in Game 1 of the bi-district series on Friday. CHS ends its season.
Kamryn Cottrell went all seven innings for Monterey (27-7).
Monterey led 6-1 after scoring a run in the top of the fifth but Cooper tallied three in the bottom of the inning to cut its deficit to 6-4.
Monterey got a run back in the sixth and secured the win with four in the seventh.
Tish Williams knocked in seven runs for Monterey.
Jada Willis had two RBIs for Cooper.
Kaleigha Kemp and Summer Simmons were in the circle for Cooper.


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A team from Canada and the USA determined whether 6-mercaptopurine (6-MP) metabolite profiles provide a biochemical explanation for 6-MP resistance in patients with inflammatory bowel disease (IBD).
Approximately 40% of IBD patients fail to benefit from 6-MP/azathioprine (AZA).
Recent reports suggest 6-thioguanine nucleotide (6-TGN) levels independently correlate with remission.
An inverse correlation between 6-TGN and thiopurine methyltransferase (TPMT) has been described.
The researchers determine whether dose escalation optimizes both 6-TGN levels and efficacy in patients failing therapy because of subtherapeutic 6-TGN levels and its effect on TPMT.
A total of 51 IBD patients were included in the study.
|IBD patients resistant to 6-MP/AZA therapy:|
- Suboptimal 6-TGN levels
- Preferential 6-MMPR production
| Gastroenterology |
Therapeutic efficacy and adverse events were recorded at baseline and upon re-evaluation after dose escalation.
6-MP metabolite levels and TPMT activity were recorded blinded to clinical information.
Some 14 of 51 failing 6-MP/AZA at baseline achieved remission upon dose escalation. This coincided with significant rises in 6-TGN levels.
Despite increased 6-MP/AZA doses, the authors found that 37 patients continued to fail therapy at follow-up.
Dose escalation resulted in minor changes in 6-TGN, yet a significant increase in 6-methylmercaptopurine ribonucleotides (6-MMPR) and 6-MMPR:6-TGN ratio.
6-MMPR rises were associated with dose-dependent hepatotoxicity in 12 patients (24%).
The team researchers found that TPMT was not influenced by dose escalation.
Dr Marla C. Dubinsky, of the Cedars-Sinai Medical Center, University of California in Los Angeles, USA, concluded on behalf of fellow colleagues, "Serial metabolite monitoring identifies a novel phenotype of IBD patients resistant to 6-MP/AZA therapy.
"These individuals are biochemically characterized by suboptimal 6-TGN and preferential 6-MMPR production upon dose escalation."


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22 Jump Street star Jonah Hill has apologised after using homophobic language towards a photographer who was following him in California.
Celebrity news website TMZ obtained a video showing the actor lashing out at the man at the weekend after he made a comment about his floral shorts.
The 30-year-old can be heard telling the paparazzo to: "Suck my ****, you ******."
On Tuesday Hill told the Howard Stern radio show: "What I said in that moment was a disgusting and hurtful term. I shouldn't have said that."
He said he should have just not responded or instead said "**** you".
Hill said the man had been following him for hours and said hurtful things about his family.
He added: "I played into exactly what he wanted and lost my cool and in that moment, I said a disgusting word that does not at all reflect how I feel about any group of people."
The actor has been an outspoken supporter of gay rights in the past. In November he tweeted about his opposition to Russia's anti-gay laws.
He also posted a photo of himself wearing a T-shirt saying "Love Conquers Hate" in Russian.
The Wolf Of Wall Street star has also spoken about having "tons of gay friends, gay family members".
Hill is currently busy promoting the sequel to 21 Jump Street which he stars in with Channing Tatum.

domain: celebrity


Ottawa is set to ban a number of assault-style firearms and weapons involved in mass shootings in Canada and abroad, including the Ruger Mini-14 that was used during the 1989 École Polytechnique massacre, federal officials say.
The formal announcement of the gun ban is expected by the end of the week, but the key measures have already been approved by cabinet, the officials said.
In addition to the gun ban, according to officials, the government will be putting forward further gun control measures in a coming legislative package.
Along with the Ruger Mini-14, the government will ban the AR-15 and similar types of firearms that have been used in a number of mass shootings in the United States, officials said.
The Globe and Mail is not disclosing the names of the officials because they were not authorized to speak publicly on the matter.
Public Safety Minister Bill Blair said earlier this year that the buyback program could come later than the ban.
The AR-15 family of firearms is often in the headlines for tragic reasons; It's commonly used by mass shooters in the United States. »


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Matt Chausee, the CEO and co-founder of Be More Colorful, has a whole world of immersive, 360-degree job experiences at his fingertips, all in the name of helping students identify careers in which they may be interested. Inside the company’s office in the NDSU Research and Technology Park, Chaussee opts to cue up footage from the construction of the RDO Building in downtown Fargo, immediately transporting the viewer into the active construction site.
The sky-high view is thanks to CareerViewXR, the platform Chaussee and the Be More Colorful team have developed over a two-and-a-half-year period.
Chaussee, working alongside wife and co-owner Katie and four other employees, said the platform has a simple goal in mind. “Just like a home virtual tour where you can navigate through the home, we’re creating virtual tours of job shadows and field trips so that you can get an immersive experience,” he explained. “What we’re really working to do is use immersive media to help create authentic experiences that align the right people with the right careers.”
The journey started when Chaussee bumped into Michelle Kommer, then North Dakota’s Commissioner of Commerce, at a tourism convention in June of 2019. Chaussee pitched his idea for CareerViewXR to Kommer, which spawned a meeting with the state’s Workforce Development Council.
That meeting was a roaring success, Chaussee said, giving CareerViewXR a boost. “I had 15 minutes to talk and everyone was buzzing,” he recalled. “We ended up with two clients straight out of that meeting.”
Those two early clients were the North Dakota Building Trades Union and Fargo-based General Equipment and Supplies. Don Shilling, the chairman of General Equipment and Supplies, took an immediate liking to the platform’s potential for showcasing careers in diesel. “He immediately said, ‘This is something we absolutely need.’,” Chaussee said.
Next came interest from Williston and Devils Lake, two cities which applied for Perkins V grants to fund more of CareerViewXR’s experiences. The dominos have been falling since, and now Chaussee estimates 70 to 80% of Be More Colorful’s business is focused on CareerViewXR.
CareerViewXR features three different experiences.
The fastest is a work environment tour, which offers a quick peek inside an active worksite. One such option is elevator construction, which features three scenes inside one of the RDO Building’s elevator shafts.
The next option is a field trip, which is a more “storyboarded” tour of a facility. These offer an inside look at places many people have never seen before, like a wind turbine near Langdon. “These scenes are really impactful because you’re looking at this and the first thing you’re thinking is, ‘Oh my gosh, that’s a big ladder.’,” to the top of the turbine, Chaussee said while walking through the field trip.
For a full day in the life view of a specific job, CareerViewXR also features job shadows. The job shadows are the longest tours and allow viewers an in-depth look at a realistic work day for a given profession. At the end, viewers can watch quick question-and-answer videos from the professionals themselves.
All three experiences are loaded with what Chaussee called “hotspots”, buttons on which viewers can click for more information. The experiences can be viewed on a desktop computer, tablet or mobile device. “All of the devices that students are already using are now in play to be able to use these experiences,” he remarked.
Those with access to …….


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Posts Tagged ‘Zoe Beaulac’
1849 – Charles Abare married Zoé Beaulac 165 years ago in Coopersville, New York. (4th great-granduncle)
1872 – John Ross (19) married Agnes Anderson (18) in Bay City, Michigan 142 years ago. (2nd great-granduncle)
1916 – Josephine Cleckey Lapan died 98 years ago in Bay City, Michigan at 42 years old. (wife of Alfred Lapan, 2nd great-granduncle)
1916 – Arthur Mondoux was born in New York 98 years ago to Antoine Mondoux & Adeline Benson. (1st cousin 3x removed)
1920 – Audry Gee Wertman died 94 years ago in Alpena, Michigan. She was 10 years old and her parents are listed as William Gee & Clara Doughty. (great-grandaunt)
If you have information about any of these people or if you would like more information, please contact me!

domain: history