BenchmarksFour Businesses Making an Impact With Bold Eye Motifs Published 2 years agoon March 8, 2017By INVISION Staff Share Tweet Would you find it cliché if a restaurant incorporated a food motif into their logo or décor? Probably not. Yet many in the eyewear business resist doing the same with eyeglasses. If a cliché becomes a cliché by being true, it transcends by being unique.Eyewear design and décor can become so ubiquitous that they disappear. Stock art of beautiful people wearing luxurious eyewear fades into the background instead of grabbing attention. It’s as true of shop interiors as it is for signage and exteriors. Our readers who have had success incorporating eye motifs into their businesses have one thing in common: Individuality. It’s a quality often heralded in this business even though it’s difficult to achieve. Eyecare customers can see the standard art and ornamentation in a big box store or online. If you want them to spend their money at your place, give them a reason – a symbol – they can’t ignore.You are in the business of matching people who need eyeglasses with the products and services they can’t find on their own. Nothing is more fitting than eyeglasses as your dominant motif. It’s the symbol of the very thing you do better than anyone else. As evidenced by some of the most successful and engaging businesses in the industry, a thoughtful eyewear motif brings your shop’s vibe and products into focus for discerning customers.Reclaimed RenovationAmerican Vision at the Court, King of Prussia, PADr. Gary Kirshner and his wife, Cindi, moved their shop to a new location three years ago. They took the opportunity to revamp their look by hiring a sculptor to create a massive pair of unisex eyeglasses out of reclaimed wood and steel. Once they hung the sculpture on spokes, a blank wall became a highly visible statement about their shop and their vision.“I think it can be a cliché. You have to be very careful of becoming too cutesy, too overdone,” says Cindi, the store manager at American Vision at the Court. Advertisement The store is dominated by a 9-foot reclaimed wooden eyeglass sculpture. The Kirshners commissioned a sculptor to create the piece. After lots of communication and revisions, the finished piece was born. And it’s perfect.“It’s a piece of art. It actually speaks. It says exactly who we are. We are understated, high end, sophisticated … and we sell eyeglasses. That piece of art says all of those things,” she says.“When the light hits it creates an additional shadow. It’s amazing. Absolutely amazing. It has done everything we wanted it to do and then some.”Stay FrostyThe Eye Gallery, Ypsilanti, MI First you notice the frosted glass eyeglass logo on the front window. The store has your attention. Owner Dr. Arnold Bulos worked with a graphic designer to create the simple logo so it didn’t look like anything else. Advertisement “It’s not pulled off the internet,” Bulos says. “All of those are pretty lame. This is slightly different, and it’s our logo throughout the store.”Bulos uses it on every patient correspondence. He believes in branding, and in efficient design.“I had to work with what I had and all I had was a glass storefront.”Now he has a brand.Visual StimulationLaFollette Eye Clinic & The Eyewear Gallery Jacksboro, TNOwners Andy and Elizabeth Howard, both optometrists, had a golden opportunity when designing their clinic and gallery. They imagined their location as a blank canvas without limitations. Together with a builder, designer and architect the couple landed on a simple theme: A celebration of vision. Advertisement “That led to custom and varied lighting, unique handmade furniture, and large eyewear sculptures complete with acrylic lenses,” Andy says.“Patients are greeted by vibrant colors throughout the building from The Eyewear Gallery to the clinic spaces.”The finished product is a happy place — a quality on which Elizabeth insisted – with a visual surprise around every corner.Clear VisionUlla Eyewear, Madison, WIFrames are the focal point of this clean and classic store featuring pops of color like a turquoise wall and animal print rugs. “We elected to have our frame boards away from the windows so we could use them as another form of advertisement,” says Margot Lanham, sales manager.Mounted on pipes, the window boards are colorful, lit like artwork and project eye-catching eyewear images to passersby.“Our store owner, Brittany, has an incredible eye for design and her choices with the store are purposeful and unique.”This article originally appeared in the March 2017 edition of INVISION. Related Topics:BenchmarksINVISION March '17store design click to Comment(Comment)Up Next6 Businesses Putting Meaning Into Their Cause MarketingDon't MissSix Businesses With a Fresh Approach to Displaying Frames Advertisement SPONSORED VIDEOSPONSORED BY WALMAN OPTICALPeople Want to Buy Premium ProductsWalman Optical Presents—Industry Myths Busted! It’s up to every ECP to explain that “premium” doesn’t mean expensive—it means “customized to your needs.”You may like Maryland Optician Makes the Most of Its Expansive Front Window Space Ways ECPs Are Benefiting from Short Intro Videos for Their Practices 9 ECPs Share What Adding an In-House Lab Has Meant to ThemPromoted Headlines Safilo’s “American Eyes” Video Celebrates Elasta and Emozioni starringECPs Peter Tacia and Heidi DancerSafilo Hoya: The Right Lenses for Sun ProtectionHoya Nano Vista—The Quintessential Line for KidsAlternative and Plan B EyewearBenchmarksWhen Their Tech Lets them Down, These ECPs Have Things Covered And their patients appreciate the human touch. Published 2 months agoon March 26, 2019By Heath Burslem TECHNOLOGY: IN OPTOMETRIC terms it means unparalleled accuracy, speed and convenience. But real life has a way of throwing up cases that just won’t cooperate with the latest equipment. And blackouts can strike anywhere. This is an industry whose gear continually evolves, but it’s also one of accumulated knowledge and, occasionally, improvised solutions. We asked around to see what kinds of tricks opticians and ODs have up their sleeves. If the lights go out while you’re in the chair or at the dispensing table of any of these eight ECPs, you’ll be in good hands.Carissa Dunphy, Lake Stevens Vision Clinic Lake Stevens, WAOptician Carissa Dunphy believes it’s important to take both digital and manual measurements from every free-form progressive wearer because she sees differences in patients’ body language towards a camera/iPad versus a person doing a manual measurement. Tech doesn’t always accommodate for specifics noted by the optician, such as someone who is really tall or short, she says. “A fitter of free-form progressives should know how to measure for each position of wear (POW) value manually and should measure both ways, comparing the values and critically thinking about the right solution for that particular patient.”Bridgett Fredrickson, Whelan Eye Care Bemidji, MNLow-tech solutions have a special place in the heart of a veteran administrator like Bridgett Fredrickson at Whelan Eye Care. She and her doc are probably the only ones in her office who know how to handle an exam on paper. “About once a year we have to pull out a form … while our computer software is down.” She knows of older ODs who never came to grips with electronic records, and younger docs who would stare blankly at a paper form. “Those of us [from] that bridge era have a unique perspective and appreciate the old way and the new.”Adam Ramsey, OD,Iconic Eye Care Palm Beach Gardens, FLAn old-fashioned technique Dr. Adam Ramsey uses regularly is trial frame refraction, which he finds spares him headaches with patients that are particular. Ramsey says it’s a “great way to move the phoropter out of the way and deal directly with the patient.” If he finds prism in the patient’s previous glasses, he will “usually skip the fancy toys and go straight to the trial frame to refract that patient. Using fixed PD trial frames gives … the best comfort.” Most patients appreciate the extra care, he says, especially when they can visualize the improvement right away.Mike Davis, OD, Opti-Care Eldersburg, MDDr. Mike Davis is nothing if not prepared. We’re confident his patients could enter his practice in a blizzard-induced blackout and come out seeing perfectly. He keeps a paper acuity chart around, along with a hand-held retinoscope and ophthalmoscope, and trial frame and lens sets. His iCare tonometer is battery powered, and with a PD stick at hand he’s “ready to roll.” The hand-held equipment Davis uses was primarily brought in to save space, but “by happy coincidence” it’s mostly battery-driven, so he’s confident he could get by for a day or so without power. “The art of hand neutralization, figuring out the prescription … with a lensometer, is helpful on house calls and nursing home visits, but mostly a good party trick.”Marc Ullman, OD, Academy Vision Pine Beach, NJ“I … have inserted punctal plugs outside in the sunlight with a jeweler’s headset when the power is out,” proclaims Dr. Marc Ullman with justifiable pride. Magnification is weaker with the headset than behind the slit lamp, Ullman says, but he feels most doctors should be able to insert punctal plugs with a headset if necessary. He has most brands and sizes of collagen and silicon plugs on hand and has lately been using the six-month extended plugs more often. “Punctal occlusion generates a lot of referrals and happy patients at my office,” he says.Advertisement Jen Heller, Pend Oreille Vision Care Sandpoint, ID“It may be silly,” says Jen Heller — a champion of the humble PD stick — “but I can prep a pair of glasses anywhere, anytime, with all the lights out and just a dinky little flashlight, and so can all our staff.” Some facilities might sniff at the idea as “backwards,” but Pend Oreille Vision Care still does hand-measured PDs on all orders, because they found that it was easy for rookie staff to lose track of where they’re placing a traditional pupilometer on squirmy kids, or adults with broken noses. “With a hand ruler, everyone can see exactly where that crook in the nose is — or, better yet, take a relaxed PD over the top of a patient’s previous prescription to rule out that plunging eye turn in high hyperopes.” Rulers are cheap and plentiful, and all staff are trained to take manual PDs. This way, Heller says, “patients never have to wait around because someone else is using a piece of equipment or because all dispensing tables are full. Get the needed measurement, and go!”Pablo E. Mercado, LensCrafters Alpharetta, GAAlpharetta, GA-based optician Pablo Mercado told us that outside of screwdrivers and pliers, the PD stick is the one tool he cannot work without. “With it, I can forgo most of the technology at the office and still feel confident I can deliver quality eyewear.” While his workplace has a sophisticated digital system, “for some cases it is a complete dud” and Mercado reaches for the stick. It comes in especially handy when taking measurements from children. But he also uses it to measure the thickness of a frame when edging — and he’s just getting started: “I use my PD stick to show patients how a couple of millimeters can make the difference between being able to wear a particular frame or not,” and to train coworkers. He also finds it indispensable when inspecting eyewear for quality control.Sarah Bureau, sbspecs St. Catharines, ON, CanadaNow here’s a really old-fashioned idea: Repair, don’t replace. According to sbspecs owner Sarah Bureau, a modern mobile business based in St. Catharines, ON, Canada. “The general consensus when we, as an industry, are presented with a broken or wear-worn frame is to recommend it be replaced.” But Bureau insists that an acetate frame that has been well loved and has now turned white can be brought back to its original lustre by sanding and polishing the acetate by hand. Using a clavulus or hot fingers to replace a hinge, whether riveted or hidden, can save your client from having to replace a temple or frame front, she says, while cracked acetate rims or broken bridges can be repaired by fusing the material back together and filing and polishing by hand. These are especially valuable options for frames that are no longer in production. The approach does more than just demonstrate Bureau’s concern for the environment; giving your client the option of a repair, she says, is a great way to build a strong and long-lasting relationship with them. “Offering these services results in their confidence in you as a professional and the retention of them as a loyal client.” Continue ReadingBenchmarksWays ECPs Are Benefiting from Short Intro Videos for Their Practices Practice introduction videos have multiple benefits, and these days they’re a cinch to produce. Published 3 months agoon February 18, 2019By Heath Burslem Introducing yourself to potential patients and customers, eliminating the element of surprise for first-timers, and boosting your SEO and Google rankings: Producing a professional-looking intro video for your practice has multiple benefits and doesn’t have to bust your marketing budget. Check out this handful of practices that have embraced multimedia.Precision VisionEdmund, OKPrecision Vision in Edmund, OK, designed their video to help patients get to know the practice before coming in. “The video was structured to try and eliminate surprises,” says owner Dr. Selina McGee. It plays on the website and her Facebook page, boosting SEO across channels and driving traffic to the practice. McGee hired a videographer to shoot and edit the video for about $800. “I wanted it to look completely professional.” McGee’s main goal was boosting SEO, but now that she’s got the video up and running she concedes she could probably do an even better job of getting patients to see it. She’s also come to realize it has other potential benefits. “Customers always want to see the real you, so create something authentic that shows your personality,” she advises. “Have fun with it. Remember, your patients and customers can’t buy YOU down the street.”Advertisement Spanish Oaks EyecareCedar Park, TXSpanish Oaks Eyecare’s video involved some luck. It was professionally done. “However,” says owner Dr. Dina Miller, “we were approached by [a crew] wanting to use our waiting area for a film. So in exchange they offered to do it at no charge.” The video walks the audience through Spanish Oaks’ office, with both exterior and interior shots, before showing Miller examining a patient and reviewing their optomap results. It ends with the patient in the optical working with her optician Bob. “During that part, we let people know how we’re different than most opticals and why — we carry only independent frame lines.” The video, whose main goal Miller says is to introduce Spanish Oaks to potential patients and customers, is posted on Facebook. “It’s a great way to … make yourself ‘real’ and familiar.” She advises other ECPs to make sure the video features actual staff. “That’s one of the most important parts; making it personable. I was tempted to have someone else sit in for me but at the end of the day, I knew that would really take away from the video and its purpose.” And don’t be afraid to edit: Miller opted for voice overs, as they had felt uncomfortable speaking to camera, and added captions for things she wanted the audience to know (for example, the fact that her optician is one of just two people with an active American Board of Opticianry Advanced certification in her part of Texas). “Also,” she advises, “consider having parts where you and possibly your main staff talk to the camera about what’s important to you, what sets you apart from others — not the generic ‘We have the best customer service/patient care,’ etc.”Ziegler Leffingwell EyecareNew Berlin, WIAccording to Dr. Dave Ziegler, Ziegler Leffingwell Eyecare hit on the idea of making an intro video as a way of giving “strong visual exposure of what it is like to be in our office.” And they found a striking way to do just that, hiring a real estate photographer to use a drone, which opens the video hovering outside the front of the office, then enters through the front door and flies throughout the office. “This flight path through the office is the way our patients experience our office during a typical eye exam,” he says. The video boasts a script written by Ziegler himself; he hired a professional to do the voice over for maximum impact. He felt it was important that the video should be less than a minute long; it’s now posted to the practice’s website, one among many features that he says win their website routine praise. Asked whether the time and expense that went into making the video were worth it, he replies that more than that, “it is necessary” for any practice, in his view.Advertisement Dr. Bladh ODDiamond Bar, CAThe folks at Dr. Bladh OD, a Diamond Bar, CA practice, understand the power of videos to increase a business’s Google ranking by boosting the amount of content that links back to its website. They signed up with a company called Promo! that allows them to make multiple 15-second videos. “The [Promo!] site has a ton of content with professional videos to use.” Once you edit it, the video is yours to keep. So the video is professionally done, but everything added to it is DIY. “Video marketing gets so much more traction than pictures or boring blog posts,” reports Josh Bladh. The videos are similar, but each has its own emphasis. Most feature music and a few lines of text to get people’s attention. “Search engines are putting more emphasis on video content so this seemed like the best option to get our foothold with video before paying for anything professional,” he says. The videos are posted to Facebook and Instagram. “We will add videos to blog posts on our website where relevant.” In the practice’s experience, consumers typically need six to eight touch points before they’ll call and commit to an exam. So, using videos to boost these contact points for the service’s relatively low monthly fee makes sense. Bladh warns ECPs to do their homework before signing up for such a service, however, as some companies will give you a hard time if you attempt to use any unused video credits after letting your subscription lapse.Anthony Aiden OpticiansNew York, NYAnthony Aiden Opticians went for a more adult approach in their video, a 30-second short about … a misunderstanding. It may seem like male fantasy, but optician Anthony Gaggi swears it’s based on reality. “My sister’s friend was a stylist; she was working alone one night and…” Well, we don’t want to spoil it; suffice it to say whether you find it hilarious, titillating or offensive, there’s no denying it conveys the store’s edgy, fashion-conscious style. “My goal,” Gaggi says, “was to bring a high-quality fashion video to my website.” The video is also displayed in the store’s windows. A friend who works in TV offered his services for free; Gaggi says clients love it. Continue ReadingBenchmarks5 Eyecare Businesses That Prove That the Way to Clients’ Hearts is Through Their Stomachs For these businesses, delicious tastes and smells are a selling point. Published 4 months agoon January 30, 2019By Heath Burslem IT SHOULD BE SELF-EVIDENT, but “experts” can dash off a list of reasons why offering delicious baked goods to your customers can be good for business. Sure, it sounds a little …well, sexist frankly … but the Journal of Consumer Research once reported that women were more likely to make impulsive decisions when exposed to “appetitive stimulants” such as the smell of chocolate chip cookies.Less scientifically, perhaps, a California jewelry store owner once told our sister publication, INSTORE, that “nine out of 10” people who stopped by for the express purpose of sampling his wife’s legendary lemon pie ended up buying something. Then there’s the argument that free food and drink makes customers feel obligated to buy something because, after all, you’ve just improved their day. And if you’re hosting an event, freebies can at least give participants a reason to stick it out to the bitter (or bittersweet?) end.But all this doesn’t even touch on the staff-bonding boost to be had from getting employees to whip up — and show off — goodies of their own. It’s clearly a way to add the personal touch and further differentiate yourself from your local big box. But truth be told, bringing in baked goods doesn’t have to be part of an elaborate strategy or cross-promotion; it can simply be an honest, generous, down-home way to connect with staff and customers as human beings, no strings attached … and regardless of gender. Eye Candy Delafield and Mequon, WIThe name is Eye Candy, and they don’t disappoint. Owner/optician Paula Hornbeck makes a priority of organizing baked goods and sweets for trunk shows and other special events. “It’s always a hit,” she says. “Who doesn’t like cake!” Melissa, one of Eye Candy’s opticians, loves to bake cupcakes and will often whip up a fun flavor for a trunk show. For the store’s birthday party each year, Hornbeck orders up a custom cake from a local baker. Staff are allowed to tuck in, “Just not when they’re busy with customers.” Eye Candy’s offerings tend to be event-driven; for that reason, flavors and styles are usually seasonal. And they’re always free. Health warnings and lawsuit fears are not really Hornbeck’s style: “Big eye roll,” she yawns. “No. I believe in personal responsibility. If you have a diet restriction then ask what’s in the treats or don’t have any.” Her advice to ECPs sitting on the gingerbread fence: Take the plunge… and “Have fun with it!”Advertisement EyeShop Optical Columbus, OHEvery Friday is Dessert Friday at EyeShop Optical. Patients like it so much many of them schedule their appointments on the day. Owner Dr. Cynthia Sayers started the tradition because at her daughter’s preschool every Friday was Cookie Friday. She found that parents — who on other days just picked up their kids and took off were hanging out around the cookies on Friday, and more willing to engage with other parents. “If it could work at a daycare, surely it could work at an optometry office.” Sayers does the baking herself. “It’s one of my hobbies, so it’s enjoyable for me. I typically bake cupcakes, but it can be cookies or other treats depending on the occasion or mood. I will take requests from patients and yes, the employees often partake.” The biggest request she gets are for her s’more cups (chocolate chip cookie cup with a ROLO inside, and toasted marshmallows and chocolate on top). No strings attached here; the cupcakes are put out for any and all to eat (though kids are told to ask permission from a parent). “Baking is relaxing for me and … a way to bring the homey feeling I try to create into my business,” says Sayers. Discerning Eye Iowa City, IARaising the bar on free, home-cooked treats is Joni Schrup, owner of Discerning Eye in Iowa City, IA, who personally bakes something for her patients every single day, ranging from cookies, bars and shortbread to ginger snaps and candied bacon. “Customers are always asking for my recipes and we keep copies handy at our front desk.” Located in the heart of a college town, Discerning Eye has 20,000 starving University of Iowa students and workers traipsing hungrily past her doors daily. So she got cooking. “We offer cookies or bars or homemade snacks every day.” When she spoke with us there was a plate of chocolate shortbread cookies and ginger snaps on the counter. “The all-time favorite is candied bacon, which I only make in December.”Advertisement Edina Eye Edina, MNOnce, Edina Eye in Edina, MN, had a greeter in the office, one of whose tasks was to pour coffee and hand out cookies. Times change, greeters move on. But when Edina’s treat-dispenser left, staff noticed that while the snacks hadn’t generated a lot of comment when plentiful, once they were no more, employees heard about it. “Patients missed it,” recalls retail operations manager Bob McBeath. “Now we do it once a month or so sometimes around an event,” McBeath says. “Usually one of the managers picks them up. We do not take requests.” The munchies are free: “No strings attached, although we ask that parents help the kids.” To ECPs worried about litigation or other forms of blowback in an era of fat shaming, gluten-free diets and anti-junk food ordinances, McBeath says simply: “Buy it, put up an ingredient poster.” Something weird he’s noticed about offering free goodies, though: “Patients act like they’re stealing them.” Urban Optics San Luis Obispo, CAIf you happen to find yourself in California’s Central Coast region, check the sea breeze for a whiff of cinnamon and follow your nose into San Luis Obispo’s Urban Optics for an eye exam and a treat; the practice buys them from a favorite bakery and hands them out to customers and patients. “We stock the office with baked goods most commonly on Saturdays, our most leisurely day,” as owner Dr. Dave Schultz puts it. “We use Black Horse Espresso and Bakery; our favorite caffeine stop. Our go-to items are Bear Claws; they fill the office with the smell of cinnamon.” Obligingly — and rather sensibly —these are cut into individual claws for ease of scoffing. Over the years, Schultz and his team have discerned various eating patterns among their grateful — if rather particular — patrons. Schultz breaks it down thus: “There’s the guy who mauls and devours every claw in sight; the mom who’s trying to control her child’s sugar intake; the vegetarian who won’t eat bear; the old lady who secretly wraps several in a napkin to take home for dinner…. oh yeah, and the PETA members who wants us to serve Pear Claws!” Continue ReadingAdvertisementLatestTrendingVideos Press Releases3 days agoABB OPTICAL GROUP and Paragon Vision Sciences Announce Fifth Annual Optometry Student Challenge Headlines3 days agoShopko Optical Acquisition Completed; 80 Stores to Become Freestanding Locations Sanity Files3 days agoFor This Miami OD, It’s the Simple Things That Get Him Back On Track Press Releases3 days agoSafilo and David Beckham Announce 10-Year Eyewear License Agreement Headlines4 days agoFDA Approves Drug for Diabetic Eye Disease Headlines4 weeks agoEyewear Executive Dies Unexpectedly Headlines3 weeks agoOnline Eyewear Seller Gets More Prison Time Headlines2 weeks agoWalmart and Optometrists Agree On New State Bill Headlines3 weeks ago2 Accused of Selling Counterfeit Ray-Bans in $2M Fraud Case Headlines4 weeks agoEyewear Chain Launches Drive-Through Pickup Service INVISION Podcast3 weeks agoPodcast: What the Heck is Marketing? 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“The Alleys,” “The Legend of Zeineb and Noah” and “I Can Hear Your Voice… Still” were the big winners of the Cairo Film Connection, the co-production platform of the Cairo International Film Festival.
“The Alleys,” the directorial debut from the Oscar-nominated “Theeb” producer Bassel Ghandour, was awarded the primary $50,000 OSN Network prize for purchasing the film’s screening rights, as well as the $10,000 Badyã Award and $10,000 New Century Productions Prize.
Currently in post-production, “The Alleys” is a Jordan, Egyptian, French and Saudi co-production about a charming hustler who pretends to be a white-collar career man in a gossip-ridden, violent neighborhood.
The jury, comprising Jordanian actor and producer Saba Mubarak, Moroccan producer Lamia Chraibi, and Egyptian filmmaker Abubakr Shawky, was slated to give out 21 awards from 18 different companies, but they added three more to the list during the ceremony.
“The Legend of Zeineb and Noah” by acclaimed Egyptian director Yousry Nasrallah, whose 2012 film “After the Battle” competed for the Palme d’Or, took home five of those awards (Mad Solutions and Ergo; Media Ventures Award; Lagoonie Film Production; Sparkle Media Group; The Cell for color grading; and Clakett) for a cash value in excess of $50,000.
Produced by Ali El Arabi, Nasrallah’s “The Legend of Zeineb and Noah” is about a 13-year-old girl, Zeineb, living in a small town in Upper Egypt in the run-up to Easter. Her best friend and cohort is her 16-year-old Christian neighbor Noah, who legend has it lives in a haunted house. The duo discovers that the demon haunting the house is not from the Underworld. The film is in development.
Sameh Alaa’s fiction “I Can Hear Your Voice… Still) also won five awards (Arab Cinema Center; Film Independent; Red Star for Production and Distribution; The Cell for a promotional package, and Sparkle Media Group). Produced by Mark Lotfy, it’s the story of a sheltered teenager girl, Rim, who takes matters into her own hands to raise money to pay her father’s hospital costs. Venturing into the night, Rim challenges social norms and faces prejudices and harassments all the while struggling against internalized misogyny.
Of the documentary projects in post-production, “The Last Projectionist” produced by Thomas Kaske and May Odeh, recently the recipient of the Variety MENA Award, won The Cell for prize for a DCP package. Directed by Alex Bakri, the film follows Hussein Darby’s attempts to be recognized as a cinema projectionist by a German NGO. The Egyptian doc “Before the Final Picture,” the story of acid attack victims helmed by Aya Yusuf, won two prizes (New Black for offline edit, and IEFTA Award).
The in-development documentary project, Olfa’s Daughters, by Kaouther Ben Hania, whose recent narrative, The Man Who Sold His Skin, played in Competition at the Venice Film Festival, won the Rotana Group cash prize of $10,000. Featuring acclaimed Arabic actress Hind Sabri it details the trauma of a Tunisian mother whose two daughters have been radicalised by fundamentalists.
Merieme Deghedi, Cairo Film Connection Manager said, “With three of our sponsors deciding to double their awards it showed the support for cinema even in times of the coronavirus. This meant we had a record $260,000 to distribute tonight.”
The industry event ran as a hybrid event this year. In the Arab region, Deghedi says, “People don’t like online, they want to meet face to face, so the challenge was making guests not on the ground feel part of the event. This was successfully achieved with other 150 one-to-one meetings taking place either physically or digitally. People managed to connect, and it’s that connection which is most important, not the awards.”

domain: artistic


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This page shows the publications co-authored by Peter Kraft and Karen Costenbader.
A lipid-related metabolomic pattern of diet quality. Am J Clin Nutr. 2020 12 10; 112(6):1613-1630.
Genetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes. Genet Epidemiol. 2019 10; 43(7):844-863.
The connection strength for co-authors is the sum of the scores for each of their shared publications.
Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.

domain: literature


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L’ Innomable Records
|Luka Zagoričnik, Head of label|
|discogs bandcamp facebook|
L’ Innomable has been dealing with artists from all over the world such as John Butcher, Christof Kurzmann, Michel Doneda, Jonas Kocher, Seijiro Murayama, Margarida Garcia and.
When releasing artists from Slovenia, the label is often collaborating with Sploh Institute, with whom they've released works by the accordionist , the double bass player and some others. In 2012, they have co-released the Neposlušno / Sound Disobedience compilation album which features some of the most active Slovenian protagonists of the free improv musical scene, with the afterword written by the British percussionist Eddie Prévost.


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I'll be moving back to Chicago in about 1 week from today, from San Diego. I don't have a super-tight deadline, but should make the trip in no more than probably 5 or 6 days (4-5 nights probably). That being said, I really want to be able to "take my time with a purpose" and enjoy the scenery and what the trip has to offer. I want to go the northern route (Utah and Colorado via 70/80), but so far the only planned night stop I have is in Denver... I would love to see the Grand Canyon, Zion, etc. I haven't done a great deal of research as to what good natural things there are to see/do on this route yet, but I know from word of mouth that both Utah and Colorado are beautiful and have a lot to offer. Camping is a potential option as well. I would appreciate any advice on any of the following:
- Where are other good, logical places to stopover for the night?
- What are some "must-sees" that I shouldn't miss? (both in terms of nature and cities)?
Again, this doesn't have to be a perfectly executed trip in terms of practicality/convenience, but I don't want to go too far out of my way either.
Any help or wisdom would be greatly appreciated. Thanks so much!

domain: travel


Canadian Western Bank has been on Jasper Avenue since 1995, when it occupied just two floors in an office tower.
But on Monday, the bank announced it’s moving to the Ice District, taking its 1,200 employees with it.
“You’re going to be overlooking the square. You can go across to the hotel, right next door will be the grocery and food fair, and Stantec will be kitty corner on the square,” explained president and CEO Chris Fowler.
He said CWB wants to be in the middle of the action, in a location with amenities that will entice employees back to an office designed for a modern work environment.
Eighty-five per cent of their workforce has been working at home through the pandemic.
“We’ll have a branch on the main floor, a big lobby on the second floor, and then the office tower,” Fowler said.
The tower will be one of the final buildings added to the Ice District, he explained, adding construction is just starting now.
The company expects to move in January 2026.
CWB’s departure is another in a long line of vacancies along Edmonton’s historic Jasper Avenue.
“There is a lot of vacant space, a lot of empty buildings,” said Cory Wosnack, Avison Young Commercial Real Estate’s managing director.
Avison Young puts Edmonton’s office vacancy at 17 per cent, a far cry from the 8 per cent Wosnack said is ideal for a balanced market.
“Ice District has been getting most of the attention for where development has been taking place, but there’s been a lot of renovations and redevelopment of older buildings, 1980’s buildings, along Jasper Avenue,” Wosnack explained.
Avison Young is seeing what they call a “flight to quality,” where companies seek out modern, efficient buildings stocked with amenities.
“Right now, property owners need to think of their ground level space as a loss leader: an opportunity to create the right programming that, even at a lower rental rate, is an attraction for the building.”
He said that could include things like restaurants, but also fitness centres, meeting rooms and gathering spaces.
“We’re seeing this blend of office space that are becoming more like luxury hotels,” he said.
Puneeta McBryan, the Downtown Business Association’s executive director, said the vacancies and boarded-up buildings along Jasper Avenue are just temporary in this transition period.
“It’s often more affordable, in times like this, to move into a brand new building than what you were paying in an older building if you signed a lease 5 to 10 years ago.”
And Wosnack was quick to point out that some of the older offices are simply becoming obsolete and need to be repurposed into something entirely different.
“Forty-eight per cent of all the vacant office space downtown is in just 10 buildings.”
Some companies are already investing in the revitalization of Jasper Avenue, including Bitcoin Well and Innovate Edmonton.
“Edmonton is leading all the other major cities in Canada in terms of the return to downtown activity,” Wosnack said.
McBryan added the pandemic has slowed down re-development plans, but said she expects things to turn around quickly as more companies bring people back downtown.
READ MORE: 2 sports restaurants announced for downtown Edmonton’s Ice District
“In the next six to 12 months, a lot of those vacant or boarded up buildings that we’ve been seeing in the last little while will already be under construction or opening as something else,” she said.
“I think by this time next year, it’ll already feel like a bit of a different story on Jasper Ave.”
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So, I am trying to brainstorm the best way to simultaneously run two operating systems in the background at the same time on the rpi4. I want to basically run a computing heavy OS and a storage heavy OS at the same time on the same rpi. (Just as an example, like running an OS that can run folding@home, and a crypto node OS like Rokos OS).
1. Which OS or containerizing program can achieve this?
2. If I were to scale this to multiple rpi’s (all running two unique OS’s not the same as the two listed above), should I cluster them together to share resources? Or keep them as separate machines?
3. If I keep them as separate machines, is there any reason to Ethernet them together, or should I keep them wired completely separately? (I ask because whether this project becomes a cluster or not, I am building it as if it looked like a cluster). The build I have in mind just looks cool, whether is functions as a cluster or not.
3 posts • Page 1 of 1
Containers do process isolation. All containers use the kernel of the host. To run an entire OS in isolation you need a virtual machine.
"S'il n'y a pas de solution, c'est qu'il n'y a pas de problème." Les Shadoks, J. Rouxel


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domain: game


text:
Gibson is ready to find his forever home! This super sweet boy is only around 3 years old, and only weighs about 45lbs. He’s completed an obedience training program and is ready to be the BEST boy for his new family!! He’d do well with another well balanced dog or as an only pet.
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domain: pet


text:
54 books — 150 voters
Goodreads helps you keep track of books you want to read.
Start by marking “Justin Bieber” as Want to Read:
by Kathleen Tracy (Goodreads Author)
Justin Bieber has rocketed to international fame thanks to homemade videos posted on YouTube. His meteoric rise to the top of the music charts is a Cinderella storywith a digital-age twist. Before he was famous, Justin had to overcome many struggles. His parents divorced when he was young. At school, he was frequently bullied because he was smaller than the other kids his ...more
Hardcover, 32 pages
Published August 15th 2010 by Mitchell Lane Publishers
To see what your friends thought of this book, please sign up.
...What? I really read a book about Justin Bieber , you ask? Why yes , yes indeed I did xD Was it intresting , you ask? Sure was. Do I like him? Yeah , I guess. Am I going to camp outside for a day and a half to get tickets to see his concert? I only have one thing to say bout that. Suck my dick , Justin Bieber
One problem with trying to do a biography on Justin Bieber is that he's young and new enough, there just isn't a lot to talk about. Sure you can throw a lot of photos in a book and teen girls will love it, but this book seems to cater to the "fandom" rather than educate. I'd pass.

domain: library


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New Washington, DC, plan to target children's medical issues
Washington Post, February 29, 2008
A new public-private partnership in Washington, DC, will target some of the worst health problems affecting th city's youth. The Child Health Action Plan sets targets for reducing the incidence of these diseases and conditions such as asthma and obesity by 2012 or earlier.
- Providers Lag as Consumers Set Agenda
- Look Beyond Nurse-Patient Ratios
- Esther Dyson Launches Population Health Challenge
- Crisis Spurs Healthcare Payment Reform in Arkansas
- Reform Puts Vise Grips on Physicians
- ICD-10 Delay Alters Provider, Vendor Prep
- Hospital Groups Back NQF Report on Patient Sociodemographics
- NPP Demand Rising Under Value-Based Care Models
- Payment Reform Naysayers 'Better Wake Up'
- Reduce Readmissions by Activating Patients to Do 'Self-Care'

domain: medical


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The Texas Office of Inspector General (OIG) has opened investigations on four Texas Medicaid dental providers and requested dental records from those offices, though it has not identified those providers.
While most Texas Medicaid dental providers take pride in their work and deliver excellent care to their patients, the OIG said, those who try to cheat the system and fail to maintain a standard of care are finding it harder to hide.
Advanced technology and experienced staff help the OIG uncover potential fraud, waste, and abuse faster than ever, the OIG said. Its Fraud Detection Operation (FDO) reviews volumes of data to reveal providers who appear as statistical outliers among their peers.
Investigators then evaluate additional records and information to determine whether an outlier’s status is attributable to possible fraud, waste, or abuse or another explanation. Providers are required to provide the records requested by OIG investigators.
In July 2020, an FDO focused on questionable dental billing practices analyzed claims data from more than 5,500 providers. Outliers in the Houston area were identified based on billing patterns for general dentistry services.
The OIG notes that mistakes can happen in any practice, so its analysis identifies outliers or behavior that may indicate fraud, waste, or abuse that needs closer examination. For instance, providers are flagged for a closer look if they bill:
- A high number of procedure codes performed during a single visit without billing for sedation or general anesthesia.
- Tooth-specific procedures performed on teeth that per ADA should have already been shed.
- A high average number of resin restorations performed per client per visit.
The FDO data analysis revealed a provider who billed for a client with 18 procedure codes, including resin restorations, crowns, pulpotomies, and tooth removal, all performed on the same date and without anesthesia. Another claim involved a three-year-old client with 31 procedure codes, including five resin restorations, crowns, and pulpotomies.
As a result of the FDO, the OIG opened investigations on four providers. Dental records were then requested to verify if:
- Dental services were requested/received by the client.
- Records include supporting documentation for services billed to Medicaid.
- The client has valid preoperative radiographs.
The investigations of the four providers are ongoing.

domain: law


text:
Have your teeth been cleaned by a dentist or hygienist this year? We know it’s difficult to find the perfect time during the pandemic, but it’s still important (if not more so) to maintain regular check-ups for you and your family.
That’s because professional dental cleanings aren’t just for keeping your smile bright; they have a significant impact on your long-term oral health. Tooth decay, gum disease and several chronic oral issues all take root with insufficient regular habits. Brushing and flossing at home are essential but regular check-ups with your dentist ensures your teeth are thoroughly cleaned and any needed preventative measures are taken. That way, no one in your family ends up with a bigger or riskier issue during this time.
So, here are five reasons professional cleanings are so important
- Your dental hygienist removes surface blemishes that you can’t remove with at-home brushing. You’ll be left with a brighter smile while preventing long-term stains.
- Regular teeth cleaning prevents one of the biggest contributors to early tooth loss – gum disease.
- In America alone, one person dies from oral cancer every hour. Many of these cancers are curable if detected at an early stage during routine cleanings and exams.
- During a dental cleaning, your dentist will detect early signs of problems such as cavities, broken fillings and fractures!
- Many dental plans cover cleanings but not more invasive surgeries. You’ll save money on dental expenses in the long run by taking advantage of your policy and scheduling a cleaning today!
- Regular check-ups and dental cleanings help prevent and resolve persistent bad breath.
Professional dental cleanings give your dentist or hygienist an opportunity to compare the state of your oral health to that of previous visits. If you’re moving in the wrong direction, immediate intervention prevents bigger problems from occurring. Call the team at Vacendak Dentistry to schedule your dental cleaning and get back on track, today! Please note, even if you don’t need an appointment for several months, it’s a good idea to get on the calendar now, as our COVID restrictions may limit short-term appointment availability.


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Sendes vanligvis innen 5-15 dager
The second volume of Sergey Prokofiev's recently uncovered "Diaries" covers the years 1915 to 1922. It describes in detail the genesis and the problematic path to performance of major works in his canon, and the life-changing experiences of living in war-torn and revolutionary Russia, and deciding to leave for the mythic America he had long dreamed of visiting. "The Diaries" chart the author's swings of fortune, the loneliness of the emigre, his encounters with a luminous range of personalities from music, theatre, art and literature, and the search for love and friendship, all cast in the burnished prose of a born master, not just of music, but of words.
FABER & FABER
|Antall sider||784||Dimensjoner||16,5cm x 24,4cm x 5cm|
|Vekt||1304 gram||Leverandør||Bertram Trading Ltd|
|Andre medvirkende||Anthony Phillips||Emner og form||Autobiography: arts & entertainment, Individual composers & musicians, specific bands & groups, 20th century & contemporary classical music|


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|Boulder Mountain Set|
- Arched Stone Bridge
- Circuit of track track connected to road
- "Deserted" Building
- Green-leaved Maple Tree
- Red-leaved Maple Tree
- Railroad Crossing Sign
- Boulder Mountain with Boulder
- Oliver is included in this set, despite not appearing in the TV Series episode.
- The set was updated in 2007 to include the redesigned Oliver.
- One side of the prototype Arched Stone Bridge in this set has a brick pattern, while the top and the other side of the bridge has a stone pattern. The released version of the bridge only has the brick pattern on both sides and the top.

domain: entertainment


text:
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ISIS Destroys Armenian Genocide Memorial Church in Der Zor
DER ZOR, Syria (Armenian Weekly)—The Islamic State for Iraq and Syria–ISIS–forces destroyed the Armenian Genocide Memorial Church in Der Zor, news agencies in the Middle East reported.
The reports surfaced as Armenia was celebrating the 23rd anniversary of its independence on Sept. 21.
Armenia’s Foreign Minister Edward Nalbandian issued a statement condemning the destruction of the church, which housed the remains of victims of the Armenian Genocide, calling it a “horrible barbarity.”
Nalbandian called upon the international community to cut the Islamic State’s sources of supply, support, and financing, and eradicate what it referred to as a disease that “threatened civilized mankind.”
The church was built in 1989-1990, and consecrated a year later. A genocide memorial and a museum housing remains of the victims of the genocide was also built in the church compound.
Thousands of Armenians from Syria and neighboring countries gathered at the memorial every year on April 24 to commemorate the genocide.
Many refer to Der Zor as the Auschwitz of the Armenian Genocide.
Hundreds of thousands of Armenians perished in Der Zor and the surrounding desert during the genocide. In summer 1916 alone, more than 200,000 Armenians, mostly women and children, were brutally massacred by Ottoman Turkish gendarmes and bands from the region.

domain: sociology


Thông tin ebook
Tóm tắt tác phẩm
From the Earth to the Moon (French: De la terre à la lune) is an 1865 novel by Jules Verne. It tells the story of the Baltimore Gun Club, a post-American Civil War society of weapons aficionados, and their attempts to build an enormous sky-facing Columbiadspace gun and launch three people - the Gun Club's president, his Philadelphian armor-making rival, and a French poet - in a projectile with the goal of a moon landing.
The story is also notable in that Verne attempted to do some rough calculations as to the requirements for the cannon and, considering the comparative lack of any data on the subject at the time, some of his figures are surprisingly close to reality. However, his scenario turned out to be impractical for safe manned space travel since a much longer muzzle would have been required to reach escape velocity while limiting acceleration to survivable limits for the passengers.
The character of Michel Ardan, the French poet in the novel, was inspired by the real-life photographer Félix Nadar.
It has been some time since the end of the American Civil War. The Gun Club, a society based inBaltimore and dedicated to the design of weapons of all kinds (especially cannons), meets when Impey Barbicane, its president, calls them to support his idea: according to his calculations, a cannon can shoot a projectile so that it reaches the moon. After receiving the whole support of his companions, a few of them meet to decide the place from where the projectile will be shot, the dimensions and makings of both the cannon and the projectile, and which kind of powder are they to use.
An old enemy of Barbicane, a Captain Nicholl of Philadelphia, designer of plate armor, declares that the enterprise is absurd and makes a series of bets with Barbicane, each of them of increasing amount over the impossibility of such feat.
The first obstacle, the money, and over which Nicholl has bet 1000 dollars, is raised from most countries in America and Europe, in which the mission reaches variable success (while the USA gives 4 million dollars, England does not give a farthing, being envious of the United States in matters of science), but in the end nearly five and a half million dollars are raised, which ensures the financial feasibility of the project.


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text:
Gambling license approved for Cowlitz casino
The Associated Press
WASHINGTON — The National Indian Gaming Commission has approved a gambling license for a proposed casino to be operated by the Cowlitz Indian Tribe in southwestern Washington state.
Wednesday's commission decision details rules for gambling at the proposed casino, but does not authorize the tribe to conduct gaming at the site, near La Center, Clark County, about 15 miles north of Vancouver.
The gaming commission is independent of any federal agency, including the Department of Interior and its Bureau of Indian Affairs.
Interior Secretary Gale Norton is considering the tribe's application for a land-in-trust agreement that would allow the Cowlitz — a landless tribe with offices in Longview — to open a casino and hotel on 152 acres of pasture off Interstate 5, about 25 miles north of Portland.
Tribal gambling operations are also subject to state approval.
If approved, the $510 million Cowlitz Casino and Resort would be the closest Indian casino to the Portland metropolitan area. The Confederated Tribes of the Grand Ronde operate Spirit Mountain Casino, about 60 miles southwest of Portland, while the Confederated Tribes of Warm Springs are seeking to build a casino, hotel and conference center in Cascade Locks, Ore., about 40 miles east of Portland.
Gaming commission Chairman Phil Hogen called Wednesday's ruling significant, but stressed that the panel is an independent agency with no direct influence on the Interior Department.
In a letter to Tribal Chairman John Barnett, Hogen said the decision was "not intended to provide any recommendation to the Secretary of the Interior regarding the Tribe's pending fee-to-trust application, or to affect the secretary's discretion in making the fee-to-trust decision."
Hogen said the panel based its approval on the Cowlitz tribe's receiving federal recognition in 2000, its historical ties to the area, and the fact that it has no reservation or other trust land.
David Barnett, a Cowlitz member who is leading the effort to establish the casino, said the tribe was pleased at the panel's decision.
"This is just a small part of a long and large process," Barnett said.
The proposed casino would feature a 134,150-square-foot gaming floor and a 250-room hotel.
The BIA is considering the tribe's application to have 152 acres at the La Center-I-5 junction declared federal trust lands. That would be a crucial step in earning agency approval for gaming there.
An environmental impact statement on the project is expected next year. The tribe is working in partnership with the Mohegan Tribe of Connecticut, which owns the Mohegan Sun casino in Uncasville, Conn.
Copyright © 2005 The Seattle Times Company

domain: news


text:
Pharm I exam I
4 L =
V/T x C
dose (mg) / [in bld]
loading dose =
Vd x [desired in serum]
(Vd x k)/ T1/2
extraction ratio =
Ca-Cv / Ca
rate of elmination /[ drug in plasma]
rate of elmination =
urine flow x [drug in urine]
the sutdy of drugs on biological system
application of pharmacological prinicpals to clinical patients
any substance which can affect a biological system
therapeutic factors taht affect the administration of a drug:
onset of action
site of action
drug factors that affect the administration of a drug;
adv: safe, economical, noninfectious
dis adv: inactivation, palatability, slow onset
adv: can give large volumes, accurate, and fast onet
adv: slow absoprtion but constant, long duration of acitivyt
disadv: slow onset
adv: rapid onset, duration of action is longer than IV
disadv: can cause tissue damage
the study of doses
the amount of drug given to an animal to have an effect
the amount of drug per unit body weight
types of doses:
therapeutic, lethal, toxic
minimal therapeutic dose
the small amoutn that has a therapeutic effect
maximal therapeutic dose
the largest amount that can be tolerated without producing toxic effects
the optimal dose, which lies between the maximal and minimal doses. has a desirabel effect
Mediam effective dose. affects 50% of the animals
meidal lethal dose. kills 50% of the animals
the amount that produces undesirable clinical, hematological, biochemical or pathological alterations
relative safety of drugs is calculated by:
standard safety margin
the higher the TI the safer the drug
Standard safety margin
ssfactor = Ld1/Ed99
ld1-ed99/ed99 x 100 is a percent that is more accurate then TI
anesthetics can be harmful to...
small mammals and breeds with short respiratory tracts
cows lack ______ on certain organs?
dont use ______ on rabbits
an enzyme tha tis used for conjugation. NOT IN CATS!!! will help to metablize salicylate (asprin).
the half life of asprin in cats will _______ due to little of what enzyme?
increase, glucuronyl transferase
opiods in cats will cause miosis? T or F
FALSE!! causes mydriasis
asprin use in dogs....
will cause an inflammatory reaction due to the convertion of arachadonic acid to leukotrienes instead of PGs
single nucletotid polymorphisms. in less than 1% of the population. no necessarily in a gene,and do not alwyas affect protein functions
"indicative SNP" are not within the gene. do not affect protein funciton.
affect hte way a protein fucntions. there si coding and noncoding
coding causative SNP
located in the codon region to change the amino acid sequence
noncoding causative SNP
located in the gene regulatory sequence changes the level of gene expression.
what do the young and the old have in common?
-decrease ability to biotransform
-decrease drug excretion
-decrease protein binding
NSAID effect on a nomral patient
will decrease COX-2 = decrease inflammation
decrease COX1 = decrease vasodilation = decrease bld flow to kidney
NSAID effect on hypotenion patient
total lack of blood flow to the kidney. can lead to renal failure
genetically determined unpredictable abnormal reaction to drugs.
fever, uticaria, anaphylaxis
resistance to ordinary dose of a drug. decrease responsivness to repeated doses of same or similar drug
tolerace to a drug type other than the one that induced tolerance
acute tolerance to repeated administration of a drug.
time scale = hours
the rate of elminiation is slower then the rate of absorption
occurs following concurrent or sequential administration of drugs.
can be summative, synergistic, additive, or antagonistic.
can be beneficial or toxic
enhace the excretion of weak acid drugs by ion trapping
enhances the excretion of weak base drugs by ion trapping
factors related to the enviornment
stress, diet, temp, humidity, oxygen
transfer of a drug from the site of injection to circulation
factors that affect absorption related ot the drug:
degree of ionization
dissolution in water
concentration at the site
route of administration
how does molecular size affect absorption?
small = fast absorption, aqueous diffusion or thoruhg a lipid channel
large = absorption is lower via facilitated diffusion or endocytosis
how does lipid solubility affect absorption?
increase lipid content = increase diffusion
increase water solubility= decrease diffusion`
how does ionization affect absorption?
nonionized drugs are more important for passive diffusion
increase NI/I ratio and increase diffusion
how does dissoluiton in water affect absorption?
-oral absorption of a liquid is faster than a solid
how does concentration at a site affect absorption?
- high concentration will increase absorption rate.
how does route of administration affect absorption rate?
oral is slower than injection
factors that affect absorption related to the drug
-absoring surface area
how does blood flow affect absorption?
increase blood flow = increase absorption
bld flow can be modified by heat, massage, other drugs, sympathetic NS, and edema
hear tnad kindey disease will.......(bld flow)
increased edema therefore decreased blood flow
shock will ___ blood flow
decrease blood flow therefore decrease absorption.
how does the absorbing surface area affect absoritong?
increase surface area = increase absorption
upper part of the SI is the best area for this
will determine the rate of absorption in the SI
what about an individual can impact absorption?
food presense in the GIT
diarrhea will___ absorption
first pass effect
drug biotransforamtion that will reduce the quantity of drug that reaches circulation.
-per os administration
-occurs due to gastric enzymes
movment of drugs from blood to tissues
what affects distribution ofa drug?
make up of the drug
the formation of a substance is equal to its removal.
affected by area, permability, membranes, bld flow and concentration
tissues that are highly perfused
brain, heart, kidney, liver, endocrine glands
bound drugs are inactive and are unable to be filtere, metabolized, or distributed.
-reversible, pro-longs half-life
-keeps the drug high in the plasma low in the tissue.
mostly bind to albumin
what affect does liver failure have on protein binding?!
protein bidning will be decreasebecause the liver amkes the palsma proteins
tissue binding consequences:
may increase the concentration of a drug in a tissue
drug is pulled outof the plasma
the tissue will hold onto the drug which will increase the time the drug is in the body
Nonionized drugs exert a diffusion pressure? T or F
weak acids are trapped in...
acid compartments trap______.
the study of the movment of drugs across biological memrbanes form the time of absorption until elmination
movment from high concentration to low concentration. dependent on lipid solubility
oil : water ratio
increase the ratio = increase passive diffusion
lipophilic and hydrophilic =
O2 and N2
small uncharged polar molecules
urea and water
can passively diffuse
large uncharged polar molecuels
glucose and sucrose
will not diffuse
will not pas the lipid barrier
T or F? It is possible to look at the pK and determine if a drug is a weak acid or base?
strong acid + weak base =
(Hcl, H2SO4, PO4)
strong base + weak acid =
(NaOH, Ca2OH, KOH)
specific type of endocytosis in which the cell engulfs the molecule of drug.
often receptor mediated
no electrochemical gradient
one compartment model
all tissues and organs which the drug penetrates behaves as if they were already in equilibrium with the blood
Vd <1 =
stays in blood
Vd =-1 =
Vd > 1 =
very wide distribution
elimination is measure by?
Half-life and total body clearance
most drugs follow_____
1st order kinetics.
1st order kinetics
the rate of removal of a drug from the plasma is proportional to the concentration at a given time
chemical alteration of the drug molecule in the body which will change the physicochemical properties of the drug and its pharmacological activity
sites of biotransformation
liver, intestine, renal tubules, blood
where does biotransformation occur in the liver?
ER ---specifically the microsome
"microsomal oxidase system"
P450 system can cause what type of reactions?
oxidation, reduction, hydrolysis, and conjugation
_______ are targets for cytochrom P450 system
consequences of the P450 system
turns drug into a more water soluble form
can cause the amking of toxic or nontoxic intermdiates
______ is an inducer of the P450 system
phase I reactions
oxidation, reduciton, hydrolysis
consequences of phase I reactions:
may "flag" the drug for furthe reactions
make active or inactivate the drug
may increase or decrease water solubility
may change drug strcture
Phase II reactions:
combining a drug ot its metabolite with an endogenous substance
conjugation can occur with:
glucuronic acid---most common!
does conjugation exist in neonates?
removal or clearance of a drug out of the body
increase bld flow to the kidney = increase filtered volume
affected by milecular size and filter rate
not affect by ionization
slow compared to tubular secretion
can move against concentration gradient
NOT affect by plasma protein binding
is important for nonionized lipophilic molecules.
affected by Urine pH and glomerular filtration
highly lipophilic nonelectrolytes are ______ eliminated form teh body
how is reabsorption afect by urine pH?
change the pH will cause drug trapping and increase elmination of the drug.
how is reabsorption affected by glomarular filtration?
fluid therapy and diruteics will increase renal excretion and decrease tubular reabsorption
highly lipid soluble = metabolized first
drugs can go to teh heptic cells or the bile
criteris for going into the bile?
>300MW and polar
steriod are excreted in the_____
T or F? If there are drugs in the feces this means that there is still a chance for hte drugs to be reabsorbed?
T or F? basic drugs are excreted in milk
TRUE due to ion trapping
what the drug does to the animal
types of pharmacodynamic effects:
adverse, side, therapeutic and toxic
levels of drug action:
cell constituents that bind to an agnoist with increase affinity and trigger a cell repsonse.
most are on the cell memrbane
types of receptors:
physiological--- made for endogenous products
the increase in number or sensitivity of receptors
example of upregulation:
hyperthyroidism in cats---will cause tachycardia tdue to an increasein teh B1 receptors
decrease inteh nuber or sensitivity of receptors
causes a physiological effect. mimic
types of agonists:
produce maximal repsonse. 100% efficacy
less than maxiaml resposne <100% efficacy
drug taht binds to a spontaneousy activated cell receptor to turn it off.
acts like an antagonist
blocks the response made by agonists
types of antagonists:
binds to the receptor reversibly to prevent the agonist from binding
prevents the agonist from having an effect at any concentration due to its irreversible binding
binds to a different site than the agonist to prevent its effect
when the drug has an agonist effect onn one receptors and an antagonistic effect on another type
reversible drug-receptor binding is___
graded dosedurve measures;
ceiling, plateau, efficacy.
more important than potency.
higher the curve higher the efficacy
measured in Kd
variability in the response due to administration of the same drug does in an individual or group
variabilty in the response in the dose requried to see a measureable effect (X axis)
the smaller the dose needed to produce an effect the greater the potency
related ot the concnetration that produces Emax
can be obtained form a graded or quntal curve
the slope of the curve indicates the range of doses over which the drug acts.
shallow slope = decreased toxicity
increased slope = increased toxicity
what shape is the graded-dose curve?
agonist + antagonist on a graded dose curve will display ______
parallel shift to the RIGHT

domain: biology


text:
Moringa is one of the most commonly used natural remedies for a range of health problems. It is a multi-purpose herbal plant as it is both used as human food and an alternative for medicinal purposes worldwide. The main reasons behind its medicinal uses are its wide range of vital antioxidants, antibiotics, and nutrients including vitamins and minerals (1).
Moringa And Heart Health
Our entire body benefits when our heart is healthy. The foods we eat support our heart by reducing cholesterol, lowering blood pressure, and reducing inflammation. Adding moringa to our everyday meals may help our heart function at its best.
Moringa pods are exceptionally rich in vitamin C. One cup of fresh, sliced pods (100 grams) contains 157% of our daily requirement. This vitamin helps reduce the risk of heart disease, including high blood pressure, high triglyceride or LDL (bad) cholesterol levels, and low levels of HDL (good) cholesterol (2). In a study, results showed that people who took at least 700 mg of vitamin C daily for 10 years had experienced a 25% lowered risk of heart disease than those who did not take a vitamin C supplement (3).
One 10-gram serving of moringa powder offers 160 mg of potassium (3.4 percent DV) (4). Getting the right amount of potassium every day can help us greatly improve our lives. It is an essential nutrient for maintaining heart health. Getting enough of it is necessary to protect the heart, prevent the onset of a stroke and improve the organ’s ability to circulate blood to the body, thus reducing the risk of heart diseases (5).
Magnesium helps our heart keep the beat, as it is involved in transporting other electrolytes that are all important for nerve signals and the muscle contractions of a normal heartbeat. Experts found that deficiency in this mineral increases irregular heartbeats known as arrhythmias. Furthermore, low magnesium levels were also linked with atrial fibrillation (afib), the most common heart rate disorder, according to a review published in May 2019 in Cardiology Research and Practice (6).
Being rich in antioxidants, taking moringa every day can help us fight free radicals and diseases (7).
In addition to vitamin C and beta-carotene, the medicinal plant also contains powerful antioxidants including quercetin (which may help lower blood pressure) and chlorogenic acid (8).
The watching, interacting, and participation of any kind with anything on this page does not constitute or initiate a doctor-patient relationship with Dr. Farrah®. None of the statements here have been evaluated by the Food and Drug Administration (FDA). The products of Dr. Farrah® are not intended to diagnose, treat, cure, or prevent any disease. The information being provided should only be considered for education and entertainment purposes only. If you feel that anything you see or hear may be of value to you on this page or on any other medium of any kind associated with, showing, or quoting anything relating to Dr. Farrah® in any way at any time, you are encouraged to and agree to consult with a licensed healthcare professional in your area to discuss it. If you feel that you’re having a healthcare emergency, seek medical attention immediately. The views expressed here are simply either the views and opinions of Dr. Farrah® or others appearing and are protected under the first amendment.
Dr. Farrah® is a highly experienced Licensed Medical Doctor certified in evidence-based clinical nutrition, not some enthusiast, formulator, or medium promoting the wild and unrestrained use of nutrition products for health issues without clinical experience and scientific evidence of therapeutic benefit. Dr. Farrah® has personally and keenly studied everything she recommends, and more importantly, she’s closely observed the reactions and results in a clinical setting countless times over the course of her career involving the treatment of over 150,000 patients.
Dr. Farrah® promotes evidence-based natural approaches to health, which means integrating her individual scientific and clinical expertise with the best available external clinical evidence from systematic research. By individual clinical expertise, I refer to the proficiency and judgment that individual clinicians acquire through clinical experience and clinical practice.
Dr. Farrah® does not make any representation or warranties with respect to the accuracy, applicability, fitness, or completeness of any multimedia content provided. Dr. Farrah® does not warrant the performance, effectiveness, or applicability of any sites listed, linked, or referenced to, in, or by any multimedia content.
To be clear, the multimedia content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read or seen in any website, video, image, or media of any kind. Dr. Farrah® hereby disclaims any and all liability to any party for any direct, indirect, implied, punitive, special, incidental, or other consequential damages arising directly or indirectly from any use of the content, which is provided as is, and without warranties.


text:
SNOW ORCHID is a captivating ensemble that will leave everyone in awe. This light purple ensemble features intricate light blue and green floral embroidery that is simply breathtaking. The light green organza dupatta with floral borders adds an extra layer of elegance.
Advance payment is required for this outfit.
This outfit will be dispatched within 2 weeks.
-Do not use any kind of bleach or stain removing chemicals
-Do not over expose damp fabric to strong sunlight
-Iron at moderate temperature
-Do not wash at home
The fabric pattern/laces, patchwork, and handmade details may vary. Actual colors of the outfit may also vary from the colors being displayed on your device.


text:
Book adapted by ANDREW LLOYD WEBBER and JEREMY SAMS
Music by Harold Arlen and E.Y. Harburg
Additional Music by Andrew Lloyd Webber and additional lyrics by Tim Rice
Lions and tigers and bears, oh my! Revisit your childhood in this beloved classic story starring your favorite characters from Kansas. Follow Dorothy and Toto as they travel the yellow brick road in search of the Wizard while coming in contact with new friends as well as dangers caused by the Wicked Witch of the West.
Sing along with the munchkins with the show’s updated look and feel — and leave feeling braver and smarter with your heart wide open.
Tickets are on sale now!
Click here for updated Covid protocols
Personal Responsibility Statement: Proctors prides itself on offering a diverse selection of arts entertainment. Not all productions may appeal to or be appropriate for every person or for all ages. Patrons are encouraged to familiarize themselves with the shows we offer in order to make informed decisions prior to purchasing tickets.


text:
Total Calories: 367
Sauté onions until golden brown in margarine. Add rinsed sauerkraut. Pour over cooked noodles. Add soup and sour cream; stir. Add drained mushrooms; reserve liquid (add if you need more liquid). Place in casserole and bake at 350° for 20 minutes until bubbly.
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My favorite is the Cook'n Recipe App.

domain: hobby


text:
Background: For radiological protection and control, the International Commission on Radiological Protection (ICRP) provides the nominal risk coefficients related to radiation exposure, which can be extrapolated using the excess relative risk and excess absolute risk obtained from the Life Span Study of atomic bomb survivors in Hiroshima and Nagasaki with the dose and dose-rate effectiveness factor (DDREF). Materials and Methods: Since it is impossible to directly estimate the radiation risk at doses less than approximately 100 mSv only from epidemiological knowledge and data, support from radiation biology is absolutely imperative, and thus, several national and international bodies have advocated the importance of bridging knowledge between biology and epidemiology. Because of the accident at the Tokyo Electric Power Company (TEPCO)'s Fukushima Daiichi Nuclear Power Station in 2011, the exposure of the public to radiation has become a major concern and it was considered that the estimation of radiation risk should be more realistic to cope with the prevailing radiation exposure situation. Results and Discussion: To discuss the issues from wide aspects related to radiological protection, and to realize bridging knowledge between biology and epidemiology, we have established a research group to develop low-dose and low-dose-rate radiation risk estimation methodology, with the permission of the Japan Health Physics Society. Conclusion: The aim of the research group was to clarify the current situation and issues related to the risk estimation of low-dose and low-dose-rate radiation exposure from the viewpoints of different research fields, such as epidemiology, biology, modeling, and dosimetry, to identify a future strategy and roadmap to elucidate a more realistic estimation of risk against low-dose and low-dose-rate radiation exposure.
All Science Journal Classification (ASJC) codes
- Health, Toxicology and Mutagenesis
- Radiology Nuclear Medicine and imaging
- Public Health, Environmental and Occupational Health


text:
Participants in IFPRI's 2017 GFPR launch say a paradigm shift is needed in food policy that bridges the needs of cities and rural areas.
Search IFPRI Web
To build sustainable solutions to global problems, stakeholders must leave the silos that constrict action and thinking. In Kenya, a public-private water partnership is bridging these gaps.
To mark World Water Day March 22, a look at how experimental games can help farmers understand—and sustain—groundwater resources.
The complex requirements of international treaties are an increasing drag on the global cooperation that agricultural research depends on.
An IFPRI seminar and a new book explore the changing role of food subsidies in Egypt's struggle with food security.
There are difficult tradeoffs in sustainable development and disaster mitigation. Identifying shared risks across sectors can help address problems before disaster strikes.
An IFPRI seminar explores possible implications of the upcoming WTO ministerial conference for Latin America.
For 25 years, we've been examining the role of gender in agriculture and in building resilience to climate change.
A look at the growing tensions between groundwater depletion, agricultural development, and food security.
Together, IFPRI and the Gates Foundation have leveraged nutritional research to improve public health around the world.