The iconic political image of the post-Reagan era, for my money, is the 2003 Schwarzenegger campaign (in the California gubernatorial recall election) using "We're Not Gonna Take It" by Twisted Sister as its theme song. To see Arnold and his fellow Orange County millionaires on stage stiffly pumping their fists to a dated song about the terrible unfairness of it all was…rich. It requires the kind of total lack of self-awareness usually found only in ancillary characters in slasher movies.
If there's one thing I honestly, legitimately do not understand about politics, it's how so many well-off conservatives have managed to convince themselves that they are the victims of an unfair society.
They are the luxuriously oppressed, the forgotten, long-suffering minority that has everything that money can buy. The urge to grab these people, shake them, and scream "WHAT IS WRONG WITH YOUR LIFE? WHAT DO YOU NOT HAVE? HOW ARE YOUR NEEDS GOING UNFULFILLED?
" is overwhelming. With right-wingers I know well, I have actually done this on more than one occasion. The amount of delusion necessary to allow someone to sit in front of a 70" TV in a giant house with two luxury cars in the garage and complain about the unfairness of it all is incomprehensible.
Recently I sat in a classroom (observing silently, neither teaching nor participating) while a group of about 20 freshmen in an honors class took turns complaining about the terrible unfairness of the concept of taxing an inheritance (the topic of the day was Edmund Burke). This segued into some broader griping about taxation – the entire concept is "wrong" and immoral because, like, what right does the government have to take MY money?
Tropes about punishing success were trodden out for their moment in the sun. And I'm watching this, half terrified and half bemused, thinking: Here is a bunch of kids at a $40,000/year private university on mom and dad's dime, to say nothing of the cars, $2000 Macbooks, "Study" Abroad trips, Greek system dues, and other expensive things with which they have been sent off to college, whining their hearts out about how thoroughly our society screws the rich. I know that college freshmen are not well-known for having a lot of perspective on anything except themselves, but it still surprises me to see such a total lack of self-awareness on display from what are supposed to be the best students in the whole crop. That anyone could have so many advantages that he or she did nothing whatsoever to earn yet still think that the deck is stacked against them is difficult to condone.
I spent the hour channeling Dave Chappelle and thinking, "Should I be choking somebody?" In hindsight, I probably should have. There are some kinds of ignorance that can't be dislodged with words.


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I have to admit of the eight remaining teams in the MLB post-season, my least favorite are the Houston Astros. Since my three favorite teams overall are, in order, the Mets, the Yankees and the Dodgers (mock me if you will, but I’ve got good reasons for each), I’ve had at least three different reasons for despising the ‘Stros.
While the 1986 Mets did indeed take down Houston in the NLCS, with a thrilling Game Six comeback that ultimately saw thme hang on in extra innings to advance to the World Serie, the way Mike Scott (a former Met!) dominated them with a questionably legal pitch was frustrating and agitating. Had the Game Six miracles not occurred, a third date with Scott would have arisen in a winner-take-all game in that God-forsaken, noisy, humid Astrodome. The Astros were clearly cheating, but baseball looked the other way. The Mets made it a moot point–until, three decades later, they revived it.
The 2017 ‘Stros, now in the American League, were proven to have stolen signs from their competition en route to their first-ever World’s Championship, taking down a valiant Yankee team and ultimately costing 2009 World Series manager Joe Girardi his job. And in the World Series, they took down the Dodgers in their own park in a blowout Game Seven that forever excommunicated Yu Darvish to the memory doghouse among their fans.
The sign-stealing scandal ultimately cost many Astros executives involved in its design their own jobs, including general manager Jeff Luhnow, manager A.J. Hinch, coach Alex Cora and bench leader Carlos Beltran. In Cora and Beltran’s cases, they had already moved on to managerial positions in Boston and New York. The Astros couldn’t appear in either city without massive boos and clanging trash cans, the gimmick that those involved used to convey what they were able to steal.
But almost lost in all of this was the fact that those Astros were damn good young talents, especially their hitters. And the 2019 team that advanced to the World Series with a new (old?) leader in Dusty Baker and even more young talent was even better. It took an overachieving Washington Nationals team, who won four road games, to deny them their second title in three years.
One of the brightest rookie stars of that team was Yordan Alvarez, who subsequently battled some injuries, including portions of this season. But he’s back now, and yesterday, with a towering three-run homer off Mariners’ ace/closer Robbie Ray, he delivered only the second post-season walk-off home run with two out in history to cap an epic comeback, from four runs down in the 7th to two runs down in the 8th to an incredulous Game 1 ALDS victory in the end.
And now, my fourth favorite horse in this tournament, the Seattle Mariners, have their own reasons to hate the “Stros.
But unlike their predescessors of the previous decade, the ’22 ‘Stros are simply talented and resillient. They pitch aggressively and never say die. And there’s not a trash can in sight.
Their fans, giddy with excitement after their first playoff series win since 2001, were crushed. But using Ray may have been an act of sheer desperation, and a sign that the Astros were indeed prepared with knowledge of how to hit an eventual starter that they had faced in the regular season, rather than a bullpen specialist that could have–and should have–been relied upon for the final out.
The Astros earned this win. They’re dangerous. And they’re staring straight at possible rematches with both the Yankees and the Dodgers to prove to their many haters that the ’17 team was too, and that they can win slightly more legally and just as successfully.
You have every reason to hate this team. But do not underestimate or disrespect them. Yesterday afternoon they earned at least that.

domain: news


Full Time Comment: That's it from the World Cup live coverage from VAVEL! Keep tuning for the latest news, scores and results of the 2014 Brazil World Cup!!
Full Time Comment: Chile suffered in the second half but managed to get the win after a late goal from Jean Beausejour in the second half. Australia showed they can be a tough opponent for any team and managed to score and even to put some pressure on Chile's defensive line. Chile completed a good outing and generated some serious consideration to make into the next round with a win in their World Cup opener!!
90+5' The game is over and Chile gets a convincing 3-1 win!!
90+4' Beausejour makes another run through the left flank but his cross didn't find Alexis Sanchez.
90+3' A great passing combination between Felipe Gutierrez and Alexis Sanchez finds Mauricio Pinilla who fails to convert, but Beausejour scores on the rebound to give Chile a two-goal lead.
90+2' Jean Beausejour scores and Chile has an insurance lead!!!
90+1' There will be four minutes added of stoppage time.
89' Chile are moving the ball in Australia's half in the last minutes. Eugenio Mena puts a ball into the attack but Mat Ryan saves it with ease.
87' Final substitution in Chile. Mauricio Pinilla replaces Eduardo Vargas.
86' Yellow card for Chilean midfielder Charles Aranguiz.
85' Alexis Sanchez puts up a shot on goal!! However, his effort goes high and wide.
84' The game has seen an Australian side decided to look forward as we go into the final five minutes. Chile struggles to get into the attack and they need to recover the ball to keep the danger away from their goal.
82' The game heads into the final 10 minutes and it seems like we will have plenty of emotion. Chile is trying to defend their lead while generating chances and Australia are decided to push forward looking for a late equalizer.
80' Beausejour has been a solid addition for Chile on the left wing, but his crosses have been quite inaccurate so far.
78' Jean Beausejour with a low cross, but a defender makes a late interception to clear the danger!!
78' Final substitution in Australia: James Troisi replaces Mark Bresciano.
77' Australia are preparing another substitution.
75' Eduardo Vargas goes into the attack but he's called into an offside position!!
73' Australia looks decided to generate chances on the attack and they have pushed their lines forward. That should open spaces for Chile on the attack.
70' Tim Cahill puts another header!! The ball goes high as the former Everton star has been a nightmare for Chile's defensive line so far.
69' Substitution in Australia: Tommy Oar is replaced by Ben Halloran.
68' Substitution in Chile: Jean Beausejour replaces Jorge Valdivia.
67' Yellow card for Australia defender Mark Milligan.
66' Eduardo Vargas and Felipe Gutierrez get into a good passing combination but nothing comes out of it. On the counter, Lackey makes a good sequence but Marcelo Diaz makes a great challenge on the last minute.
65' Leckie with a header after a cross but the ball goes high and wide.
65' Chile are slowly getting back the control of the action, something they did effectively in the first portion of the first half. Otherwise, they will continue to suffer against an Australian side that has looked quite dangerous in the second half.
63' Mark Bresciano with a shot from inside the box but the ball goes wide once again.
62' Australia saves it from the line!!! After a good pass from Alexis Sanchez, Eduardo Vargas touches the ball past Mat Ryan but a defender clears the ball from the line!!!
60' Substitution in Chile: Felipe Gutierrez replaces Arturo Vidal.
59' After a mistake from Charles Aranguiz in midfield, Mark Bresciano moves forward and puts on a low cross but nothing comes out of the sequence.
58' Yellow card for Australia's captain Mile Jedinak.
56' What a save from Claudio Bravo!!! Mark Bresciano puts up a half volley from a tight angle and Bravo makes a stretched save to clear the danger away.
55' Despite the fact that Chile controls the ball, Australia has generated some dangerous chances. Tim Cahill has been a beast and he has been virtually unstoppable.
53' Tim Cahill scores but the goal is correctly disallowed!!! The cross comes from the right and Cahill was offside before scoring.
51' On the counter, Tim Cahill puts up another header but the ball goes wide. The NY Red Bulls forward has been a headache for Chile's defensive line so far.
50' Eugenio Mena puts a good cross into the box but Australia clears with ease.
49' Franjic won't continue and he's replaced by Ryan McGowan. First substitution in Australia.
48' Australia defender Ivan Franjic is down and he appears to be injured. It remains to be seen if he will be able to continue playing.
47' There's a slight rain falling right now. That could help Chile's chances thanks to their passing.
46' Australia moves the ball and the second half starts!!
Half Time Comment: As for Australia, The Socceroos managed to score a goal and they've been better than expected in the last minutes. They are sticking up to their tactic and they are definitively going to look for their chances in the second half.
Half Time Comment: Chile has a 2-1 lead going into the halftime break but their play hasn't been as commanding as expected! La Roja scored twice in the first 15 minutes, generated plenty of chances in the first 30 minutes but after Australia pulled one back, the South American side struggled creating chances.
45+2' Nothing comes off the costless kick and the first half is over!!
45+1' Mark Milligan commits a foul against Alexis Sanchez. Dangerous chance for Chile.
45+1' One minute added on stoppage time.
45' This is Australia's goal, scored by Tim Cahill in the 35th minute.
44' Yellow card for Australia forward Tim Cahill.
43' There's some evident problems in the Chilean players right now. Most of them look dazed and confused due to Australia's recent goal.
39' Chile has had a 69% of possession thus far in the first half. They've been simply dominant but they need to reflect that on the score as they only have a one-goal lead.
38' Mauricio Isla with a shot of his own!! The Juventus right-back puts a shot from a tight angle and a defender blocks it to send it away for a corner kick.
37' Tim Cahill with another chance!! A shot from close range inside the box but Bravo makes a great save to parry it away!!
36' A good cross into the box finds Tim Cahill inside the box and the New York Red Bulls' striker nods home a header past Claudio Bravo to shorten Chile's lead.
35' Tim Cahill scores with a header and Australia pulls one back!!!
33' Eugenio Mena with a good run into the box!! The Santos FC left-back can't get the shoot and there's a corner for Chile, but nothing comes out of it.
31' Eduardo Vargas received a good ball from Jorge Valdivia but the Valencia CF striker failed to capitalize.
30' Chile continues to dominate the game and they haven't had any opposition of Australia's defensive line. It has been a convincing performance from Chile so far as the game reaches the 30th minute mark.
27' This is Jorge Valdivia's goal that doubled Chile's lead before the 15th minute mark.
26' Leckie with a good ball forward!! His cross is very inaccurate and Chile resumes the game from his own end.
25' Here's a video with Alexis Sanchez's goal that gave Chile a quick 1-0 lead.
24' Arturo Vidal with a shot from inside the box!! After a good pass from Mauricio Isla, the Juventus playmaker puts the ball into the goal but his shot goes wide.
22' Australia are clearly looking to push the ball forward but the game has been a struggle for them so far. They simply don't have the quality to penetrate Chile's defensive line.
21' Freekick for Australia, but nothing happens as Chile's defensive line clears the ball with ease.
19' Tommy Oar puts a long range shot!! However, his effort goes wide and there's no trouble for Claudio Bravo.
17' Mat Ryan finally makes a save! After a difficult shot from Valdivia, the Brugge keeper saves with ease.
16' Mark Mulligan commits a hard foul over Jorge Valdivia. Chile are dominating with ease thanks to their quick lead.
15' La Roja are completely comfortable after the first goal and now Jorge Valdivia is the one who scores the second goal!!! After a very good pass from Alexis Sanchez, the Palmeiras playmaker puts up a finesse shot past Ryan and now Chile has a quick two-goal lead.
14' Chile doubles the tally as they quickly have a 2-0 lead!!!
12' Chile moved the ball around for about four minutes and between Alexis and Charles Aranguiz managed to create a chance inside the box. The FC Barcelona striker received the ball in a tight angle and blasted the ball into the net past Mat Ryan.
12' Chile scores as Alexis Sanchez scores the first one!!!
8' Chile gets a good possession in midfield thanks to Jorge Valdivia and Arturo Vidal. However, they can't get a clean pass to either Alexis or Eduardo Vargas as Australia continues to look solid at the back.
5' Chile controls the ball with ease in the first half but they haven't been accurate in the final touch so far. Australia tries to get into the attack but Chile looks solid defensively. A very even game thus far in the first minutes.
3' Eugenio Mena with the cross!!! The pass is underhit and Australia clears the ball.
2' Chile are very clear in their tactic as they are eager to move into the attack. The South American side has plenty of players moving forward as Australia struggles to get a grasp of the ball early on.
1' The game starts and Chile goes into the attack with their first possession!!
22.59 The game will start and Chile will move the ball.
22.55 Both sides are lining up on the pitch and the national anthems are sounding in the stadium. Chile came up first and Australia is second.
22.53 Australia Substitutes Bench: Galekovic (GK), Langerak (GK), Troisi, Vidosic, Bozanic, McGowan, Holland, McKay, Wright, Halloran, Luongo, Taggart
22.52 Chile Substitutes Bench: Christopher Toselli (GK), Jhonny Herrera (GK), Mauricio Pinilla, Jose Fuenzalida, Esteban Paredes, Francisco Silva, Jose Rojas, Fabian Orellana, Carlos Carmona, Jean Beausejour, Felipe Gutierrez, Miiko Albornoz
22.50 Chile will wear their usual red kit and Australia will wear their yellow jersey.
22.48 Both teams ended their warming up exercises and we are only a few minutes away from seeing both sides getting into the pitch.
22.45 The stadium is completely filled out for this upcoming contest and we are getting closer to kick-off time for what should be an amazing match Australia - Chile.
22.40 Australia Probable Starting XI: Mat Ryan; Ivan Franjic, Matthew Spiranovic, Alex Wilkinson, Jason Davidson; Mile Jedinak, Mark Milligan; Matthew Leckie, Mark Bresciano, Tommy Oar; Tim Cahill
22.38 Chile Probable Starting XI: Claudio Bravo; Mauricio Isla, Gary Medel, Gonzalo Jara, Eugenio Mena; Charles Aranguiz, Marcelo Diaz, Arturo Vidal; Jorge Valdivia; Alexis Sanchez, Eduardo Vargas
22.35 Australia’s head coach Ange Postecoglou is expected to set their lines back against a Chile team that’s arguably better. If the previous games are of any indication, they will use four defenders, five midfielders - where Mark Bresciano will be the creative spark - and only one striker who will be Tim Cahill.
22.33 Chile has received some good news ahead of the lineup confirmations as Arturo Vidal will finally be included in the starting lineup. The Juventus playmaker trained without pain in the last days and he will be included in the lineup, giving Jorge Sampaoli a huge boost ahead of the opener.
22.30 Clearly, some of the Chilean players are not short on confidence. FC Barcelona striker Alexis Sanchez believes they are serious contenders to win it all, saying “I think we can win the World Cup. If I didn’t, I would be sitting at home in front of the television. Our first goal is to advance from the Group Stage and I’d be happy if we finish second in the Group behind Spain”.
22.28 Sampaoli recognized that Vidal's presence will be a game-time decision, saying that "we hope that he can feature against Australia but we will decided prior to the start of the match. His personality and his skill set certainly make him a valuable commodity for what we want to do on the pitch."
22.25 Chile manager Jorge Luis Sampaoli will be set for the biggest challenge of his professional career managing La Roja and his side is likely to control the action against an Australian squad that doesn’t have the talent and the experience that the Chilean players possess.
22.20 As for Chile, La Roja has plenty of talent all over the pitch. Alexis Sanchez, Arturo Vidal, Eduardo Vargas and Gary Medel are worldwide-known names but they also have some solid role players. Eugenio Mena, Marcelo Diaz and Charles Aranguiz are three players that could be decisive for the South American side.
22.15 Australia has some very interesting players on their squad but they don’t have the international experience required to be a challenging side in the World Cup. Goalkeeper Mat Ryan is coming off a great season in the Belgian Jupiler League, forward Tim Cahill continues to be a solid force on the attack playing for the NY Red Bulls and midfielder Mile Jedinak is the leader and captain of the side. Overall, however, there aren’t many players featuring in the top leagues and that could hurt them when going against the likes of Spain and Holland.
22.10 This is Arena Pantanal in Cuiaba, the venue that will host tonight’s match. It has capacity for almost 40.000 fans.
22.05 Tommy Oar also acknowledged Chile’s star power but he is eager to show the rest of the world what his side is made of. "From our perspective we know all the pressure will be on Chile going into the first game," said the 22-year-old. "We're looking forward to trying to take the game to our opponents and showing everyone what we're made of.
22.00 When asked about Arturo Vidal’s injury, Australia's captain Mile Jedinak said that "You go through their squad and it's one player," he said. "He is an important player, but they have many players who are playing at a good level and a number of players in his position who are strong.
21.55 Chile could be without one of their most important players in midfield since Juventus midfielder Arturo Vidal will likely be a game-time decision for the opener. The Juventus starlet needed a surgery in the first days of May but he recovered quickly than expected, even playing 15 minutes in Chile’s final friendly match against Northern Ireland.
21.50 The referee for tonight’s encounter will be Ivorian Noumandiez Doue. His assistants will be his countrymen Songuifolo Yeo and Burundi’s native Jean Claude Birumushahu. The fourth official will be Roberto Moreno, from Panama.
21.45 There’s plenty to know about these two teams and here we have full team previews for both Chile and Australia made by us here at VAVEL!
21.40 Here’s the recap of Australia’s final friendly match, a 0-1 loss against Croatia.
21.35 As for Australia, the team wasn’t very sharp on their recent friendly matches, with a 1-1 draw against South Africa being their best result. They also lost 4-3 against Ecuador and 1-0 against Croatia so if their performance against World Cup teams is of any indication, then The Socceroos are set to have a tough tournament in Brazil.
21.30 This is a video of Chile’s last performance where they defeated Northern Ireland by a 2-0 score thanks to goals from Eduardo Vargas and Mauricio Pinilla.
21.25 Chile is coming off a good performance in their last four friendly matches where they won three of them: against Costa Rica, Egypt and Northern Ireland, the last two with their full World Cup roster. Their only loss happened against Germany back in March but the general consensus was that Chile should’ve defeated Die Mannschaft in that contest with relative ease.
21.20 Australia qualified for the World Cup with relative ease in the Asian Qualifiers while Chile ended in third place in the South American Qualifiers. Both will collide in what appears to be a thrilling match where Chile seems to be the favorite early on according to experts and pundits.
21.15 Good night and welcome to the live commentary of this 2014 World Cup match Chile - Australia! We will be providing live updates and results of this exciting game that will close the first match day in the Group B of the 2014 Brazil World Cup!


I should of posted this a couple of days ago. Mourning the end of The Ramones’ legacy, I drank a little too much which set me a little in my daily routine. Tommy Ramone, the original drummer for The Ramones and the band’s last surviving original member, died last Friday at the age of 65 of cancer. Its a little piece of pop culture drifted on. To me The Ramones are one of my faves. They are one of the originals of the NY seventies Punk Scene. they brought an original, carefree, poppy, fifties, style of punk to the NY scene. Lost but not forgotten, they will be played and remembered forever.
I wanted to give my condolences to the Vidal family. I too have family a member that sufferers from a mental illness and has also been the victim to over excessive police violence. He was only a child that suffered from a real brain disorder. He was only 18. Mental illness is no different then physical illnes, people need to have equal compassion. He was full of obvious talents. He was excessively tasered and restrained with restraints when he was brutally murder by a police officer. This is happening way too often. Why is something not being done on a political and social level. Cops need better training.
ONE OF THE GREATEST ARTIST OF OUR TIME AND ONCE LEAD IN THE FAMED VELVET UNDERGROUND.


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Growth factors produced in the uterine endometrium are considered to be involved in the proliferation of the mouse uterine stromal cells induced by estradiol-17β (E2) and progesterone (P). The effect of epidermal growth factor (EGF) and transforming growth factor-α (TGF-α), one of EGF-related growth factors, on the proliferation of mouse uterine stromal cells was studied in a serum-free culture. The growth of the uterine stromal cells was measured by MTT assay. EGF was found to increase the number of uterine stromal cells in a dose-dependent manner. The DNA-replicating cells were investigated using the immunocytochemical detection of bromodeoxyuridine (BrdU)-labeled cells. EGF and TGF-α increased the percentage of BrdU-labeled cells in a dose-dependent manner. Administration of the combination of E2 (10−9 M) and P (10−7 M) for 2 days increased the percentage of BrdU-labeled cells 2.3-fold. The stimulatory effect of EGF, TGF-α and the combination of E2 and P on DNA replication in the uterine stromal cells was repressed by RG-13022 (10−5 M, the inhibitor of the EGF receptor tyrosine kinase). RT-PCR analysis of EGF-receptor-, TGF-α-, and EGF-mRNA was carried out in the cultured uterine stromal cells, and revealed the expression of those mRNAs. These data supported the hypothesis that uterine endometrial stromal growth induced by sex steroids required the EGF family of ligands such as EGF and TGF-α, both produced in the stromal cells, acting for DNA synthesis through EGF receptors.
The mammalian uterine endometrium consists of epithelial cells and stromal cells. The proliferation and differentiation of both the uterine endometrial epithelial and stromal cells are regulated by estrogen and progestin. Estrogen stimulates the proliferation of luminal and glandular epithelial cells in the uterus, whereas the proliferation of stromal cells is induced by a combined treatment of estradiol and progesterone (Huet-Hudson et al., 1989). Much evidence has suggested that the steroid hormone-induced growth of uterine endometrial cells is mediated by an autocrine or paracrine action of polypeptide growth factors synthesized within uterine tissues (Cooke et al., 1998). Several reports have indicated that estrogen-induced proliferation of uterine epithelial cells is mediated by epidermal growth factor (EGF) (Iguchi et al., 1985; Tomooka et al., 1986; Nelson et al., 1991; Uchima et al., 1991; Shiraga et al., 2000), while other reports have shown that transforming growth factor-α (TGF-α, one of the EGF-related growth factors) (Nelson et al., 1992), insulin-like growth factor-I (IGF-I) (Murphy et al., 1987; Shiraga et al., 1997) and heparin-binding epidermal growth factor-like growth factor (HB-EGF) (Zhang et al., 1994) are implicated in the proliferation of the uterine epithelial cells. As reported above, the regulatory mechanism of the proliferation of uterine epithelial cells has been extensively studied. However, the molecular mechanism that regulates the sex steroid hormone-induced proliferation of uterine stromal cells is not clear.
Immunoreactive EGF has been localized in the neonatal and adult mouse uterine stromal cells (Falck and Forsberg, 1996). TGF-α and its mRNA are also detected in both uterine epithelial cells and stromal cells (Tamada et al., 1991). Both EGF and TGF-α are known to bind to EGF receptors. EGF-receptor mRNA has been detected in the mouse uterine stromal cells (Das et al., 1994; Tong et al., 1996). These findings imply that EGF and EGF-related growth factors act on the uterine stromal cells in a paracrine manner. Therefore, the present study was aimed at clarifying the involvement of EGF and TGF-α in the estradiol and progesterone-induced proliferation of uterine stromal cells, since in our culture system, treatment with a combination of estradiol and progesterone stimulated the proliferation of the mouse uterine stromal cells.
MATERIALS AND METHODS
Twenty one- to twenty three-day-old female mice of the ICR strain (CLEA Japan Inc., Osaka, Japan) were used in the present study. They were housed in a temperature-controlled animal room, and were given a commercial diet of CA-1 (CLEA Japan Inc. Osaka, Japan) and tap water ad libitum. All animal experiments were performed in accordance with the Guidelines for Animal Experimentation, Faculty of Science, Okayama University, Japan.
Uterine stromal cell isolation
Uterine stromal cells were isolated according to the method of Ross et al. (1993). Briefly, uterine horns were removed from the mice and longitudinally cut to expose the endometrial luminal surface. The tissue fragments were treated with 0.1% trypsin (w/v, Type III, Sigma Chemical Co., St. Louis, MO, USA) at 4°C for 1 hr, and then at 37°C for 55 min. Trypsin was inactivated by 0.1% soybean trypsin inhibitor (STI, w/v, Sigma Chemical Co.) at 37°C for 10 min. The epithelial tissues were separated from the stromal tissues with forceps under a stereoscopic microscope. The endometrial stromal and myometrial tissues separated from the epithelial tissues were incubated with 0.1% trypsin and 1 mM EDTA at 37°C for 1 hr. Then they were treated with 0.1% STI at 37°C for 10 min. After gentle pipeting and DNase I (Sigma Chemical Co.) treatment, the stromal cells separated from the myometrium were collected by centrifugation. The cell viability was assessed by trypan blue dye exclusion test and was usually more than 95% in each study. All chemicals were dissolved in Ca2+- and Mg2+-free Hanks' solution containing 20 mM HEPES and 0.3% bovine serum albumin (BSA, w/v, Fraction V, Sigma Chemical Co.).
Uterine stromal cell culture
The isolated uterine stromal cells were cultured in a 1:1 mixture of Dulbecco's modified Eagle's medium and Ham's F12 medium without phenol red (DME/F12 medium, Sigma Chemical Co.) containing 2% dextran-coated charcoal-treated fetal bovine serum (v/v, Gibco BRL, Gaithersburg, MD, USA) (DC-FBS) (Lagace et al., 1980) for 1 day. After a 1-day pre-culture, the cells were cultured in DME/F12 medium supplemented with BSA (1 g/l), hydrocortisone (100 μg/l), triiodothyronine (400 ng/l), transferrin (10 mg/l), glucagon (10 ng/l), parathormone (200 ng/l), sodium selenite (5 μg/l) and insulin (100 μg/l). Insulin was stocked at a concentration of 10 μg/ml in sterile 1% acetic acid solution. E2 (Sigma Chemical Co.), P (Sigma Chemical Co.) and RG-13022 (BIOMOL Research Laboratories, Inc., PA, USA), a specific inhibitor of tyrosine kinase of EGF receptor (Yoneda et al., 1991), were initially dissolved in a small amount of sterile ethanol. They were all diluted with the culture medium, and the final ethanol concentrations were less than 0.01%. Mouse EGF was obtained from Sigma Chemical Co., and human TGF-α was obtained from Amersham Pharmacia (Uppsala, Sweden).
The isolated uterine stromal cells were seeded in 24-well tissue culture plates (Becton Dickinson, Lincoln Park, NJ, USA) at a density of 1–2×104 cells/ml per well for the determination of the cell number and the DNA-replicating cells, and in 9-cm tissue culture plates (Becton Dickinson) at a density of 2×106 cells per plate for RNA extraction. The culture was continued at 37°C in humidified atmosphere of 5% CO2 and 95% air.
Immunocytochemical analysis of uterine stromal cells
Uterine stromal cells were cultured on a poly-L-lysine-coated slide glass. The cells were fixed by pre-chilled 100% methanol (−20°C) for 20 min and dried at room temperature. For vimentin or cytokeratin detection, the cells were treated with 0.01% trypsin in 0.01 M PBS for 5 min at 37°C, then incubated with mouse anti-vimentin antibody (Sigma Chemical Co.) or pkk-1 mouse anti-cytokeratin antibody (Organon Teknika, NC, USA) overnight at 4°C. Vimentin-, and cytokeratin-immunoreactivity were visualized using ABC kit (Vector Laboratories, Burlingame, CA, USA).
Determination of the number of uterine stromal cells
The number of cultured stromal cells was determined by a modification of the tetrazolium assay using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT, Chemical Co.) as a substrate (MTT assay; Alley et al., 1988). The amount of formazan accumulated after 4-hr incubation at 37°C was spectrophotometrically determined by measuring absorbance at 540 nm and was used to estimate the number of the cells in a well. The amount of formazan (the optical density observed at 540 nm) was well correlated with the number of cells in culture (Shiraga et al., 1997). The cell number was expressed as a percentage by regarding the minimal cell number as 100%.
Determination of the proliferating cells
DNA-replicating cells were immunocytochemically detected using a cell proliferation kit (Amersham Pharmacia). Uterine stromal cells were seeded on a poly-L-lysine-coated slide glass. Bromodeoxyuridine (BrdU, 3 mg/ml) was added to the culture medium, and the culture was continued for 5 hr. About one thousand stromal cells were observed from each slide. The percentage of BrdU-labeled cells to total cells was calculated.
Primers of EGF receptor, TGF-α and EGF were designed based upon the mouse sequence and were obtained from the Gibco BRL Custom Primers, Life Technologies Asia Pacific (Yokohama, Japan). The primer sequences and the location on the nucleotide sequences were as follows: EGF receptor 5′ (GTGTGAAGAAGTGCCCCCGAAAC, 931–953), EGF receptor 3′ (AACGACCGCCAAAGAAAACTGACC, 1359–1382), TGF-α 5′ (AGCCAGAAGAAGCAAGCCATCACT, 367–390), TGF-α 3′ (CTCATTCTCGGTGTGGGTTAGCAA, 845–868). EGF 5′(AGATGAGTGTGTGCTGGCTAGATC, 2987–3010), and EGF 3′ (TCCGAGTCCTGTAGTAGTAAGTCC, 3529–3552).
cDNA synthesis and PCR amplification
Total RNA (2 μg) in a final volume of 20 μl was subjected to reverse transcription (RT) using Superscript II Reverse Transcriptase (Gibco-BRL) with random primers according to the manufacturer's instructions. Each PCR was performed using primer pairs specific for EGF-R, EGF and TGF-α as described above. PCR was performed using Takara Taq (Takara Shuzo Co.) and a thermal cycler (Gene Amp PCR System 9700, Applied Biosystems, Branch-burg, NJ, USA). The conditions for PCR were as follows: after activation of DNA polymerase by a 20-sec incubation at 95°C, 35 cycles (for EGF-R cDNA) and 40 cycles (for EGF and TGF-α cDNA) of reactions, including denaturation for 30 sec at 95°C and extension for 1 min at 60°C, followed by an additional extension for 10 min at 60°C. A 10-μl aliquot of each reaction was electrophoresed on 2% agarose gel, stained with ethidium bromide, and photographed under ultraviolet rays.
The size of the resulting DNA fragment following PCR amplification was expected to be 452 base pairs (bp) for EGF-R, 502 bp for TGF-α and 566 bp for EGF. The cDNA fragments were sub-cloned into pGEM3zf (+), and sequenced using fluorescent primers and an automated DNA sequencer.
Immunocytochemical analysis of cultured uterine stromal cells
Uterine stromal cells were attached to a substratum within a few hours after seeding. Phase contrast microscopy revealed that the stromal cells in the culture were flattened, and were mostly fibroblast-like in appearance (Fig. 1A). Immunocytochemical study showed that the cultured cells expressed vimentin (a marker for stromal cells) (Fig. 1B), but not cytokeratin (a marker for epithelial cells) (Fig. 1C). These observations indicate that the cultured cells consisted of uterine endometrial stromal cells.
The growth of uterine stromal cells
After a 1-day pre-culture in the medium containing 2% DC-FBS, the uterine stromal cells were cultured in the serum-free medium. Under the serum-free conditions, the uterine stromal cells continued to grow until Day 5 in culture, and the number increased 4.5-fold (Fig. 2).
Effect of RG-13022 on the incorporation of BrdU to the nucleus of uterine stromal cells
The nucleus of DNA-replicating stromal cells was labeled with BrdU, which was detected immunocytochemically. To examine whether EGF receptor-signaling was involved in the growth of the uterine stromal cells, the stromal cells were treated with RG-13022, an inhibitor of the EGF receptor tyrosine kinase, for 2 days, starting on Day 1 in culture (Fig. 3). RG-13022 treatment decreased the percentage of BrdU-labeled stromal cells in a dose-dependent manner, and in the following experiments, 10−5 M RG-13022 was used.
Effect of EGF on the number and DNA replication of uterine stromal cells
Uterine stromal cells were cultured with various concen trations of EGF (0.1 to 10 ng/ml) for 6 days. EGF increased the number of uterine stromal cells in a dose-dependent manner (Fig. 4). When uterine stromal cells were treated with EGF (10 ng/ml) from Day 5 in culture, they had increased 1.3-fold in the number over the control level at Day 7 in culture. This increase continued, 1.5-fold at Day 9, and remaining 1.6-fold at Day 11 (Fig. 5). EGF increased the percentage of BrdU-labeled stromal cells in a dose dependent manner (Fig. 6).
Effect of TGF-α on the DNA replication of uterine stromal cells
Uterine stromal cells were cultured with various concentrations of TGF-α (0.1 to 10 ng/ml) for 6 days. TGF-α increased the percentage of BrdU-labeled stromal cells in a dose-dependent manner (Fig. 7).
Effect of RG-13022 on the DNA replication of uterine stromal cells induced by exogenous growth factors and sex steroids
E2 (10−9 M) or P (10−7 M) treatment did not increase the number of BrdU-labeled cells (data not shown), whereas the combination of E2 and P significantly increased the number of BrdU-labeled cells. Similarly, EGF and TGF-α caused the number of BrdU-labeled cells to increase. To clarify how EGF receptor signaling is implicated in mediating the action of E2 and P, the uterine stromal cells were treated with RG-13022 (10−7 M) in the presence of the combination of E2 and P. The RG-13022 treatment nullified the E2 and P-induced DNA replication of the uterine stromal cells as well as the EGF- or TGF-α-induced DNA-replication (Fig. 8).
Detection of EGF-receptor-, TGF-α-, and EGF-mRNAs in cultured uterine stromal cells
RT-PCR was performed to evaluate EGF receptor-, TGF-α-, and EGF-mRNA expression in the cultured uterine stromal cells using primer pairs for the amplification of EGF receptor cDNA (Fig. 9, lane 1), TGF-α cDNA (Fig. 9, lane 3) and EGF cDNA (Fig. 9, lane 5). These amplifications resulted in single bands in the ethidium bromide-stained gels. From the size of the RT-PCR products, it was concluded that the 452-bp product, 502-bp product and 566-bp product were amplified cDNAs of EGF receptors, TGF-α, and EGF, respectively. The sequencing analysis revealed that the amplified cDNA fragments were cDNAs coding parts of the mouse EGF receptor, TGF-α and EGF, respectively (data not shown). To exclude the possibility of genomic contamination, RNA samples were amplified by PCR without RT, and no PCR products were found (Fig. 9, lanes 2, 4 and 6).
The uterine stromal cells continued to grow under the serum-free condition. RG-13022 treatment inhibited the proliferation of the uterine stromal cells even in the absence of EGF and TGF-α under serum-free conditions, which suggests the involvement of EGF-receptor signaling in the growth of uterine stromal cells. In addition, we demonstrated the synthesis of EGF and TGF-α in the uterine stromal cells and their stimulatory effect on DNA replication of uterine stromal cells. From these findings, we concluded that endogenous EGF-related growth factors were involved in the regulatory mechanism of the growth of mouse uterine stromal cells.
In our culture system, the uterine stromal cells ceased to increase in number on Day 5 in culture. However, when the medium was treated with EGF beginning on Day 5, the uterine stromal cells started to increase in number, indicating that the cessation of the growth of uterine stromal cells was partly due to the depletion of endogenous growth factors, probably EGF-related growth factors.
In the adult ovariectomized mouse uterus, the proliferation of stromal cells is induced by a combination of E2 and P (Huet-Hudson et al., 1989). In the present study treatment with E2 or P failed to stimulate DNA replication in the uterine stromal cells, whereas the combination of E2 and P stimulated DNA replication in vitro. The proliferation of the uterine stromal cells induced by the combination of E2 and P in a serum-free culture is quite consistent with the proliferation of uterine stromal cells induced by E2 and P in vivo.
The DNA replication that had been enhanced by the combined treatment with E2 and P was nullified by an RG-13022 treatment. This finding suggests that the action of E2 and P on the DNA replication of uterine stromal cells requires the EGF-receptor signaling. Therefore, EGF-related growth factors are considered to mediate the action of the combination of E2 and P through the EGF receptor. This hypothesis is supported by a previous report that in response to estrogen treatment DNA synthesis in uterine endometrial stromal cells of EGF-receptor knockout mice is depressed compared with that of wild type mice, suggesting that EGF-receptor signaling is required in estrogen-induced proliferation of uterine endometrial stromal cells (Hom et al., 1998).
EGF and EGF mRNA levels are increased by estrogen in the mouse uterus (DiAugustine et al., 1988; Falck and Forsberg, 1996). The TGF-α mRNA level is also increased by estrogen in the adult ovariectomized rat uterus (Borgundvaag et al., 1992) and in the immature mouse uterus (Nelson et al., 1992). Immunoreactive TGF-α protein is secreted at high levels into the mouse uterine luminal fluid after estrogen treatment (Nelson et al., 1992). As mentioned above in vivo analysis of EGF and TGF-α expression in the uterus has been well reported. However, physiological growth factors which are involved in steroid hormone-induced proliferation of the stromal cells remains to be determined. Interestingly, in a study of pituitary growth, we found that TGF-α is a mediator of estrogen-induced proliferation of mammotrophs, since treatment of mouse pituitary cells with antisense TGF-α oligodeoxynucleotide or anti-TGF-α anti-bodies inhibited estrogen-induced proliferation of mammotrophs (Oomizu et al., 2000; Takahashi et al., 2002; Sharma et al., 2003). These results altogether suggest that estrogen-induced growth of various tissues is controlled by a common mechanism of an autocrine or paracrine action of growth factors.
The stromal cells do not proliferate when progesterone receptor antagonists are used to block the receptor function (Cullingford and Pollard, 1988; Rider and Psychoyos, 1994) or when anti-progesterone antibodies are administered during early pregnancy (Rider et al., 1986). Progesterone is essential for the growth of uterine stromal cells. The increase in the progesterone receptor level is evoked by estrogen (Aronica and Katzenellenbogen, 1991). The mechanism of cooperative action between E2 and P needs to be clarified.
In conclusion, we found that estradiol and progesterone co-operatively stimulated the proliferation of uterine stromal cells, and that EGF-receptor ligands were involved in the steroid-induced growth of uterine endometrial stromal cells.
This study was supported in part by Grant-in-Aid for Scientific Research from Japan Society for the Promotion of Science to S.T.

domain: literature


text:
The Canon of Scripture
By Frederick P. Pogorzelski
The Bible came out of the Catholic (Universal) Church
After the death of Christ on the cross, and in the centuries before 419 A.D., there were many, perhaps hundreds of writings, and some forgeries that had to be sorted out and decided upon as to if they were canonical (canon = rule or official list) or not. The early Catholic Church was scattered out in communities over a wide geographic area. Many people in these communities liked the Shepherd of Hermas and it was very popular and read as if it were scripture. On The Shepherd of Hermas; in the document The Muratorian Fragment, approx. 170-180 A. D., it is written: "was written quite recently in our own time by Hermas, while his brother, Pius, was filling the chair of the Church of the city of Rome". ( Pope Saint Pious I apparently occupied the chair of Peter approx. 140 - 155 A. D. ). Origen ( 185-232 A.D. ) believed the author of The Shepherd of Hermas to be the same Hermas referred to by Saint Paul in Romans 16:14. The Epistle of Barnabus was accepted as Scripture by Clement and Origen but not by Saint Jerome. While both of the books; the Shepherd of Hermas and the Epistle of Barnabus, were read and accepted by many Early Church communities they are not found in today's Bibles
The Gospel of Thomas was also in circulation and accepted by some followers of Mani ( Manicheans ). Saint Cyril of Jerusalem, in his Cathechesis V ( approx. 348 A.D. ), states: "Let none read the gospel of Thomas, for it is the work, not of one of the twelve apostles, but one of Mani's three wicked disciples." Manichaeanism is a heretical idea that has echoed down the centuries and has persisted even unto today. Likewise, Gnosticism ( Gnostics were Docetists = Greek "to appear" ) teaches that salvation is liberation from the body because the material world is evil. These heretical teachings and writings were rejected as false by ecclestical authority. The important thing to remember about heretical ideas is that they will continue to re-emerge, in more virulent form ( variants ), and under different name, throughout the centuries.
Some communities did not accept the Book of Revelation (Apocalypse) as Scripture, so it was not so popularly read and it was a disputed book. The Council of Laodicea about 360 A.D. did not include Revelation in the Canon of Scripture. Cyril, Bishop of Jerusalem, also rejected it and forbade it's reading in public or private as well. Athanasius, Bishop of Alexanderia, accepted it as Scripture as it is shown in his festal letter of 367 A.D.  Disputes over the canonicity of the Book of Revelation contributed to divisions in the Eastern Church communities, and some Greek Churches of today do not accept it as Sacred Scripture.
The Bible did not come complete with an index, telling us which books, and how many, are inspired writings and canonical or not. It was the bishops of the Catholic Church under the guidance of the Holy Spirit that sorted out and decided the canon of Sacred Scripture. The bishops were preserved from falling into error, as our Lord promised, on this important matter concerning the Holy Catholic Church. (Matt. 16:18; 28:18-20) (John 14,15, and 16) (1 Tim. 3:14-15) (Acts 15:28) They included Tobit, Baruch, Judith, Wisdom, Ecclesiasticus (Sirach), 1 Maccabees, and 2 Maccabees. Roman Catholics call these books deuterocanonical. Protestants call them Apocrypha. There are some additional passages in Daniel and Esther not found in Protestant Bibles.
Relatively recent archeological findings and analysis of the Dead Sea scrolls (Qumran) of 1947 revealed that several deuterocanonical books were originally composed in Hebrew (Sirach, Judith, 1 Maccabees,) or Aramaic (Tobit). The Protestant reformers of the 16th century were not aware of the Hebrew and Aramic Versions of the deuterocanonical books in the Alexandrian canon. These are significant and noteworthy because it proves that some of these books were in circulation in Palestine and were accepted by Jewish groups there. Many of the Christian evangelists and apologists used the Alexandrian canon ( Septuagint LXX ) preserved (not composed or originally written) in Greek. Hellenists Jews from outside Palestine had their own synagogue where the Bible was read in Greek.
The Hebrews were native Palestinian Jews with their own synagogue. Their language was Aramaic and their Bible was read in Hebrew. There were complaints and disputations amongst these two Jewish groups ( Hellenists and Hebrews ), who used different languages, as is noted in ( Acts 6:1-2 ).
The Protestant Reformers (not preserved from falling into error) thought that all the deuterocanonical books in the Alexandrian canon had been composed in Greek. The Protestant reformers accept 39 books found in the Hebrew Canon. They do not accept 46 books as they thought their to be seven (7) additional books to the canon of the Holy Bible only composed in Greek (LXX). Actually, many of the the books were preserved in Greek (not composed or originally written in Greek). Here, the reformers of the 16th century had taken, or been guided into, a historical and spiritual, wrong way turn. The archeological evidence available to the reformers of the 16th century led them to believe that the deuterocanonical books were later Greek language compositions and additions to the Holy Bible. Relatively recent archeological findings and analysis of the Dead Sea scrolls (Qumran) of 1947 revealed that several deuterocanonical books were originally composed in Hebrew or Aramaic.
[In their own presumptuous way, and promoting individual authority, the reformers of the 16th century adopted a shorter 66 book canon of the Holy Bible. Today's Catholic Bibles usually count a 73-book canon of Scripture not 72. This is simply because they number the book of Lamentations separate from Jeremiah. However, once dogmatically defined, there can be no dispute as to the canonicity of the sacred books on the part of Catholics. The Reformers accept the 27 books of the New Testament.
(Martin Luther dishonored and nearly eliminated some of the New Testament books like James, Hebrews, Jude, and Revelation. The insistence of his friends stopped him from eliminating some of the New Testament canon. Luther was suffering from scrupulosity.) The 16th century Protestant Reformers were wrong about the canon - as are some modern day "Bible Christians" - such as Erwin W. Lutzer. Note the contradiction(s) in historical facts as exemplified by footnote's 4 and 5 below. As always, read both books in context.]
The Bible came out of the Catholic Church around the end of the 4th century. ( No small feat! ) The Synods of Hippo, 393 A.D., and Carthage, 397 A.D.,and later, Carthage 419 A.D., ( along with the Traditional Bible or Latin Vulgate ( LV ), 406 A.D., by Saint Jerome ),gave us the canon of Sacred Scripture as Catholics know it today. Relatively recent archeological findings and analysis of the Dead Sea scrolls (Qumran) of 1947 revealed that several deuterocanonical books were originally composed in Hebrew or Aramaic. This is very relevant and significant because earlier Protestant reformers of the 16th century, were very suspicious of, and rejected books, only available to them in the Greek Language. In part therefore, the Protestant canon of 66 books of Sacred Scripture is deficient - short seven (7) books.
The regional or local Catholic Church Councils of Hippo, 393 A.D., and Carthage, 397 A.D., and later, Carthage 419 A.D. gave us the canon of Sacred Scripture as we know it today. Although these were just local councils, Saint Augustine did insist that the list given by these councils be sent to Rome for approval. Pope Saint Siricius (384-399 A.D.) approved the canon just as his papal predecessor Pope Damasus I had done in a Synod in 382 A.D. with a formal writing "Decretal of Gelasius", de recipiendis et non recipiendis libris. (The archeological findings and analysis pertaining to the Council of Rome 382 A.D. and some of the Popes may not be a settled fact.)
A friend of Saint Jerome, Saint Exuperius of Toulouse, a Gallican bishop, wrote to Pope Innocent I in a formal letter requesting the list of canonical books. The Pope replied - honoring Saint Exuperius - with a letter listing the canonical books:
Consulenti Tibi Dated February 405 A.D.
. This list is the same as the canonical list that Catholics have today. This includes the Protestant apocrypha or Catholic deuterocanonical books of the Holy Bible.
Around the end of the fourth century more evidence on the canon is found from the Church in Spain, in the work of the heretic Priscillian, Bishop of Avila (died 385 A.D.). Priscillianism is a variant of Gnostic-Manichaean. . In his work "Liber de Fide et Apocryphis" Priscillian defends and includes the deuteros although he does not claim that all the deuteros are inspired only some. In the Early Church their was much debate on The Canon of The Old Testament.
The Ecumenical Council of Florence again affirmed the list of inspired books in 1442 A.D., about 100 years before the Council of Trent. The "Decretum pro Jacobitis" by Pope Eugenius IV lists the inspired books, and according to the common teaching of theologians, these documents are infallible True meaning of infallible states of doctrine. Since there was no urgent challenge or compelling reason why it should, the Ecumenical Council of Florence did not dogmatically pass on the canonicity of the inspired books. It did however teach that the books were inspired.
The decrees of the local or regional Church councils (Synods) of Hippo, 393 A.D., and Carthage, around 400 A.D., were submitted to the "transmarine Church" (Rome) and approved by the Popes and are considered official Church teachings by official Church councils. Although these councils were merely local, and they in themselves did not have universal binding authority, their decrees were submitted to various Popes and approved.  The Latin Vulgate (LV) version of the Bible by Saint Jerome was completed about 406 A.D. and included the deuterocanonical books. About 1000 years later, the Council of Trent, Session Four, would state: "If anyone does not accept as sacred and canonical the aforesaid books in their entirety and with all their parts, as they have been accustomed to be read in the Catholic Church and as they are contained in the old Latin Vulgate Edition, and knowingly and deliberately rejects the aforesaid traditions, let him be anathema."
The canon of the Bible was solemnly defined and made dogmatic Dogma and Classes of Revealed truth by the Fourth Session of the Ecumenical Council of Trent of the Catholic Church held in northern Italy 1545-1563 A.D. by the Decree "De Canonicis Scripturis" on April 8th, 1546. Pope Pius IV formally confirmed all of its decrees in 1564 A.D. This put the canonicity of the whole Traditional Bible (LV) beyond the permissibility of doubt on the part of Catholics. The books of the canon were listed individually and agreed with the earlier listing already taught (for about 1000 years prior to the Council of Trent) by the Ordinary Magisterium of the Catholic Church.
 The Interpreters Bible The Holy Scriptures in The King James Version, Volume XII, Page 353, Abingdon Press, 1957, Nashville 2, Tennessee
 history of Eastern Christianity, Page 248, By Aziz S. Atiya, University of Notre Dame Press, 1968, Notre Dame, Indiana
 Eastern Christianity, Page 191, By Nicholas Zernov, G.P. Putnam's sons, 1961, New York
Compare footnotes  and  below. FOOTNOTE [4} IS HISTORICALLY ACCURATE.
 The New Jerome Biblical Commentary, Prentice Hall 1990, Raymond Edward Brown, Roland Edmund Murphy, Joseph A. Fitzmyer, Editors, Englewood Cliffs, New Jersey
Page 1041, #38 states the following: "...(2) it was once thought that the extra (deuterocanonical) books in the Alexandrian canon had been composed in Greek and not Hebrew or Aramaic the sacred languages known in Palestine. Actually, a good number of the deuterocanonical books were originally composed in Hebrew (Sir, Jdt, 1 Macc) or Aramaic (Tob). The Qumran discoveries prove that some of these books were in circulation in Palestine and accepted by Jewish groups there. The fact that the codices of the LXX do not isolate the deuterocanonical books as a group but mix them in with the Prophets (Bar) and the Writings (Sir, Wis) shows that there was no awareness that these books had a unique origin, as there would have been if they were thought to be later and foreign additions to an already fixed collection translated from Hebrew. (3) The thesis that the Jews in Alexandria had a different theory of inspiration from the theory shared by the Jews in Jerusalem is gratuitous."
 Seven Reasons Why You Can Trust The Bible By Erwin W. Lutzer, Published by Moody Press, September 1998, Chicago, Illinois 60610
Dr. Lutzer states on Page 187, item 6: "Finally and most important, we must remember that the Apocrypha was never part of the Old Testament Hebrew Canon. We have already emphasized that Christ assumed that the Hebrew canon ended with the Hebrew Scriptures. The Apocrypha was written in Greek, not Hebrew, and appeared at a later time."
 Henri Denzinger's Enchiridon Symbolorum Et Definition, No. 84, Page 35
 "Faith Facts" from Catholics United for the Faith (CUF), 827 North Forth Street, Steubenville, Ohio 43952
 For earlier lists, cf. Synod of Laodicea (end of IV cent.), c. 60, the genuineness of which canon however is contested (Hefele-Leclercq, Hist. des conciles, I, 1026); Synod of Rome (382) under Pope Damasus (Denzinger, Enchiridion, no. 84); Synod of Hippo (393), c. 36, which the III Synod of Carthage (397) made its own in c.47 (idem, no. 92); Innocent I in 405 to Exuperius, bishop of Toulouse (idem, no. 96); Eugene IV in the Council of Florence (Mansi, XXXI, 1736; Hardouin, IX, 1023f.). The Tridentine list or decree was the first infallible and effectually promulgated declaration on the Canon of the Holy Scriptures
Opinion on "ecclestical authority:" I understand creedal definition, papal definition, or conciliar definition. see: Responses To 101 Questions On The Bible by Rayomd E. Brown, published by Paulist Press, New York, pages 11 - 16 and pages 73 - 74.

domain: history


Couples celebrate their parenthood by capturing memories from the time of pregnancy and go for family photo shoots to announce the birth of their children.
While many choose to pose with their children or even pets, a couple's photo shoot with their 'newborn' has made netizens laugh out loud.
The couple's 'newborn' is a zucchini, a vegetable. The couple did a family photo shoot with a vegetable that they grew in their garden. The zucchini had grown as heavy as 2 kilograms.
"We are the proud parents of a mutant zucchini. Wait... what?!?" Photographer Jenn Spain wrote while making the announcement on her Instagram page.
Take a look:
Spain and her husband can be seen posing for a photo with their 'newborn' which is covered in a cute blue blanket.
"Last week when I went out of town I asked my husband to harvest a zucchini from our garden. He did but not the one I meant and then an absolute monster grew. Yes, we are going to eat it but it's also our baby now, so of course we did a photoshoot to celebrate becoming a family," Spain wrote on her blog.
"We will definitely be having more children because we can't stop eating them," Spain added.
"If you're going to take something seriously (like zucchini parenthood) you might as well give it 110% and have fun while you're at it!" she wrote.
In June, a PhD scholar did a maternity photo shoot with her PhD thesis. She shared before and after pictures of herself with her 'baby' to express her feelings on finally completing her thesis and getting a doctorate.


The iPhone 6’s physical design received some appreciation today from someone you’d least expect. Former Android Vice President Hugo Barra today called the iPhone 6 “the most beautiful smartphone ever built” at the WSJD conference.
Barra, who played an important role in Android and Nexus launches, is currently VP at Xiami, a Chinese phone manufacturer that has been accused of copying Apple.
The Verge reports from the WSJD conference:
[Barra] was effusive in his praise for Apple’s latest devices. The iPhone 6, he said, is “the most beautiful smartphone ever built.” Barra’s comments came in response to a question about the persistent criticism that 4-year-old Xiaomi’s rise has been fueled by blatant copying of designs from Apple and others, an issue that Jony Ive raised again at an event earlier this month. “Our designers, our engineers are inspired by great products — and frankly, in today’s world, who isn’t? Point me to a product in our industry that has completely unique design language. You’re not going to be able to find one.”
To further illustrate his point about inspiration, Barra noted that the iPhone 6 “carries design that’s very HTC-like,” and added that the Control Center quick toggles were on Android much before they were on iOS. He however accepted that the toggles were much better on iOS than on Android.
Let us know what you think about Barra’s comments.[via The Verge]


text:
| Dec 21, 2013
| 10:11 PM
The Golden State Warriors defeated the Lakers, 102-83, on Saturday night, extending a double-digit lead in third that the Lakers couldn't overcome.
In addition to the expected injuries to guards Kobe Bryant (knee), Jordan Farmar (hamstring), Steve Blake...
| Oct 6, 2013
| 4:13 PM
The Lakers made their preseason debut Saturday night in Ontario, beating the Golden State Warriors, 104-95.
In a game where Coach Mike D'Antoni sat out Steve Nash and Pau Gasol to avoid playing the veteran duo on back-to-back nights (the team also plays...
| Oct 30, 2013
| 6:19 AM
After opening the season with a stunning opening-night upset of the Clippers on Tuesday night, the Lakers travel to Oakland to play the Golden State Warriors on Wednesday.
The Lakers' bench dominated the Clippers in the fourth quarter, allowing the...
| Oct 30, 2013
| 10:05 PM
Warriors 125, Lakers 94 (final)
If the NBA had a mercy rule, Wednesday night's "battle" between the Lakers and Golden State Warriors would have certainly qualified.
The Warriors were relentless, shooting a stunning 57.7% (15 of 26) from three-...
| Oct 18, 2013
| 2:56 PM
SHANGHAI — All done with their trip to China, the Lakers are ready to be world-beaters when they return to Los Angeles.
Or maybe they're just ready to be beat.
"Don't hold us to a high standard on Tuesday when we play Utah," Coach Mike D'...
| Oct 31, 2013
| 11:45 PM
This was what the crowd came to Staples Center to see: Blake Griffin slamming home three consecutive monstrous dunks, each one set up by Chris Paul, in an electrifying sequence in the third quarter of the Clippers’ 126-115 victory Thursday over...
| Nov 22, 2013
| 11:35 AM
The Lakers (5-7) host the Golden State Warriors (8-4) on Friday night at Staples Center.
After the Lakers' surprising opening-night win over the Clippers, the Warriors quickly brought the Lakers down to earth with a 125-94 trouncing in Oakland on Oct....
| Nov 22, 2013
| 10:10 PM
Lakers 102, Golden State Warriors 95 (final)
The Lakers took advantage of a depleted Golden State Warriors squad to take a 102-95 victory at Staples Center on Friday night.
Playing without point guard Stephen Curry (concussion) and backup point...
| Dec 7, 2013
| 10:01 PM
Paul George scored 28 points and the Indiana Pacers powered past San Antonio, 111-100, Saturday night, snapping an 11-game skid against the Spurs.
David West had 20 points and Lance Stephenson added 15. Roy Hibbert, former San Antonio guard George Hill,...
| Jul 20, 2012
| 8:57 AM
Dwight Howard's agent denied reports that the Orlando Magic center had agreed to sign a contract extension with the Lakers if traded to L.A.
"Dwight's position has remained unchanged since the end of this past season," Dan Fegan told Ric Bucher of ESPN....
| Jan 24, 2013
| 4:49 PM
Jamal Crawford, the Clippers super-sub guard, was not picked as a reserve for the NBA All-Star game in Houston Feb. 17.
NBA head coaches selected 14 reserves for the East and West teams. Crawford, in his 13th NBA season, has never made an All-Star...


text:
1 3/4 cups (14 1/2-ounce can) whole tomatoes, undrained and cut up
2/3 cup (6-ounce can) tomato paste
1 teaspoon dried basil leaves
1/4 cup chopped fresh parsley
How to Make It
In 5-quart saucepan, place water, chicken, onion, carrot, celery, chicken broth and salt; heat to boiling. Simmer 1 hour 30 minutes or until chicken falls off bone. Remove chicken; cool. Cut chicken into small pieces; set aside. Strain liquid through fine strainer; discard vegetables. Refrigerate broth until fat hardens on top. Skim fat; discard. Cook noodles according to package directions. In large saucepan, stir together broth, noodles, tomatoes, tomato paste, basil, parsley and reserved chicken. Heat to boiling. Serve immediately.
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domain: food


text:
We check in with Crowder from the 'Hits Deep Tour' to talk about the new deluxe edition of his 'Milk & Honey' album + touring with TobyMac, People Magazine naming his house the 'Ugliest House in Atlanta,' and more!
Multi-Platinum-selling Christian music superstar TobyMac will kick off his annual Hits Deep Tour this week on February 9th in Jonesboro, AR for a nationwide tour hitting 26 markets with 29 shows throughout the next two months concluding April 2nd. For a limited time only, the remaining tickets can be purchased for $10 (plus venue and ticketing fees). This special offer will only be available through this week ending on Sunday, February 13th. Since the launch of this sale this past weekend, more than 18,000 tickets have been sold in three days.
Multi-Platinum-selling artist TobyMac will kick off his acclaimed Hits Deep Tour next month on February 9th in Jonesboro, AR for a nationwide tour hitting 26 markets with 29 shows throughout February and March concluding April 2nd. In addition to featuring TobyMac and his DiverseCity Band, the tour will include Crowder, Cochren & Co, CAIN, and Terrian.
Seven-Time GRAMMY winner TobyMac has dropped his first single of the year, in tandem with a music video for "Help Is On The Way (Maybe Midnight)." Produced and written by TobyMac and Micah Kuiper, the new track is available across all DSPs.
Christian music group Unspoken showcases raw, authentic pop musicality across each of the 12 songs featured on the band’s acclaimed, bestselling album, Reason. The band released its fourth single from the album, “Help Is On The Way,” to radio on February 5.
“The promise I’ve been holding on to is that God will never leave us or forsake us,” explained Christian hip hop artist TobyMac as he launched Hits Deep Tour 2020 last weekend. The 7X GRAMMY® winner expressed heartfelt thanks to everyone who prayed and extended messages of love and sympathy to his family since the loss of his son Truett last October.
TobyMac’s popular Hits Deep Tour will make 32 stops nationwide in 2020. Joining TobyMac on the tour will be rising stars Tauren Wells, Jordan Feliz, We Are Messengers, Ryan Stevenson, Aaron Cole, and Cochren & Co.
Award-winning music veteran and innovator TobyMac launched Hits Deep Tour 2019 with 37 stops across the U.S. with Jeremy Camp, Jordan Feliz, Ryan Stevenson, We Are Messengers, and Aaron Cole. Hits Deep was the highest grossing Christian tour of 2018, and with the release of his new album, “The Elements,” fans are filing in to check out the latest.

domain: entertainment


text:
CSCC Castle Combe Modern Classics 12/07/2014
Richard Senter and Karen Phillips driving Karen's Impreza WRX in the
Classics and Sports Car Club (CSCC) Modern Classics event at Castle Combe.
Richard and Karen qualified in 10th position, and finished 8th overall in
the race. They finished 1st in Class C and recorded the lap record for
Class C with a best lap of 1:20.299.
This was their first driver swap race and with a more polished change-over
they may have achieved 7th overall. Many thanks to their team members Mike,
Hayley and Darren for their help with the event without which this
fantastic result would not have been possible.
Unfortunately the race was red-flagged with less than 2 minutes remaining
due to an incident involving the #85 VW Golf of Yates/Chapman. We hope
there were no injuries and they're out racing again as soon as possible.
(Apologies for the sound quality - Not sure why there's an annoying
Audi RS4 Crash - Castle Combe
Footage of an Audi RS4 crashing at Castle Combe Circuit during the Audi
Driver International 2008 track day
UK Rally Photography, for hi-res images of BTRDA, WRC and more please visit
my website, http://www.djaphoto.co.uk
Matt Withers - BMW E36 - Castle Combe Track Day & BMW Meet - 08/03/14 - RoadHawk HD
Matt Withers out for a number of laps at the Castle Combe Track Day & BMW
Meet, hosted by Ergen Motorsport & Raw Motorsport on the 8th March 2014.
Camera details below...
Footage from the RoadHawk HD camera, graphics applied using RaceRender 3.
RoadHawk HD Motorsport Kit: http://bit.ly/1cBmd0C
Use the code 'JMCB10' to get 10% off at the checkout.
RaceRender 3 (Mac & PC): http://bit.ly/1o2I0hD
Footage by Jonny Jones

domain: hobby


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By Chris Goldberg
Phillylacrosse.com, Posted 6/27/10
Hill School senior defenseman Tom Shade has made a verbal commitment to
play Division I lacrosse at the US Military Academy at West Point.
Shade, of Spring City, was a first-team Middle-Atlantic Prep League choice and an all-league Academic pick this spring for a team that tied for the league title. Shade, who plays club lacrosse for Twist, said he was impressed with the West Point coaches and the structure of the military academy.
“They showed the most interest in me and once I started to learn more about the school I got more interested,” he said. “I really like the coaches and when I met the team I liked the guys.
“I also like the seriousness of the program and the discipline.”
Shade also plays football (running back/linebacker) and ice hockey (defense) at The Hill.
“Actually, I went there to play ice hockey, but it turned out I liked lacrosse the most,” he said. “Lacrosse has become more and more my thing. I like the intensity of the game and it’s a game you never get tired of playing.”
Shade said the Blues should again be a factor in the MAPL next year.
“We’re graduating a good class, but we have a few talented players and a good rising junior class,” he said. “It looks pretty good.”
Tags: Hill School


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SEATTLE — A 20-year-old Florida resident is the second member of a violent neo-Nazi group to plead guilty in a plot to intimidate minorities and journalists, including a KING 5 reporter.
Taylor Parker-Dipeppe admitted to a federal conspiracy charge during a hearing in United States District Court in Seattle Monday morning.
Parker-Dipeppe was a member of The Atomwaffen Division, which boasted a small number of members in several states including Washington.
Court documents say Parker-Dipeppe and another Florida Atomwaffen member planned to deliver a hateful poster to the home of a journalist of Puerto Rican descent in Tampa, as part of a coordinated harassment campaign.
The feds say Parker-Dipeppe mistakenly affixed a poster to the wrong home.
Parker-Dipeppe faces a maximum five years in prison and a $250,000 fine when he is sentenced at a later date.
Parker-Dipeppe is the latest in a series of Atomwaffen members to admit to their crimes after a nationwide crackdown by the FBI.
A co-defendant, Johnny Roman Garza of Arizona, pleaded guilty to a similar conspiracy charge on Sept. 8 for attempting to place threatening posters at the homes of a Black journalist and the editor of a Jewish publication.
Two other co-defendants from Washington, Brandon Cameron Shea of Redmond and Kaleb Cole of Arlington, are awaiting trial.
In July, John Cameron Denton of Texas admitted to "swatting" journalists and a White House cabinet official. Denton admitted he made fake 911 calls that appeared to come from home addresses of his victims, spurring police SWAT team responses.
In April, Atomwaffen member Aiden Bruce-Umbaugh, formerly of Olympia, was sentenced to 2.5 years in federal prison on a gun crime.
The Atomwaffen Division professes allegiance not only to Adolph Hitler but also the late mass-murder Charles Manson, according to the group’s online videos.
In a series of reports, the King 5 Investigators showed how the group trained with firearms near Concrete, Washington in a so-called “hate camp” that brought members in from across the country.
King 5 reporter Chris Ingalls was one of the journalists targeted by the group. Shea allegedly mailed Ingalls a letter that said “Death To Pigs” and “you have been visited by your local nazis.”
Atomwaffen patriarch James Mason previously claimed the group had disbanded after the FBI’s arrests.
However, King 5’s sister station in Denver found that Mason had simply “re-branded” Atomwaffen into a new group called The National Socialist Order.


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TigerGaming Casino (tigergaming.com) is operated by Thot Management NV at Emancipatie Boulevard 29, Willemstad, Curacao
Sites like TigerGaming Casino
Tiger Gaming Casino Review 2021
Looking for a mobile sports betting site and casino? Tiger gaming might just be the best online gaming site. Even though it is one of those gaming sites hardly heard of, it has been in the industry for more than 2 decades, having been established back in 1999.
When a business has been in the industry that long, it usually is an indication that it is doing thaings right. And Tiger Gaming is just proof of that. They have a lot to offer and they meet their customers’ expectations. Not to mean that they are flawless, though, but they definitely do not have any serious flaws.
The casino offers bonuses on the first three deposits, where new players are given 100% match deposit bonuses. The offer is eligible for bonuses within £25 and £1000. The maximum bonus is £3000 and has a 40 times wagering requirement.
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Unlike what players would hope for, it is unfortunate that the casino does not have a lot of options from popular developers like Microgaming, Net Ent, and companies like Net Ent. Their main providers are from Betsoft, which isn’t as bad as Betsoft is also one of the popular developers; just surprising.
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No cap Tiger Gaming is quite a solid site. They have been in the industry for such a long time and have a valid license. Even so, there is still a lot they could improve on, like their customer support. Otherwise, everything else is quite impressive. And, it is like a one-stop-shop, players get every bit of a casino experience, from poker to slots, to sports betting.
Tiger Gaming Casino Sister Sites 2023
TigerGaming Casino opened its virtual doors in 2004 under the management of d by Action Commerce Limited. The site is under the regulation of Curacao’s government, and it assures players a safe and secure environment while enjoying their gaming experience. TigerGaming Casino a poker site, and it is operated on the Chico Poker Network. The site supports English as the primary language.
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domain: game


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At only twenty minutes from Red Wing, MN and a little over an hour away from both the Twin Cities and La Crosse, WI, Lake City is a superb destination for your next day trip. Lake City is a bustling tourist city located right on Lake Pepin, one of the most popular lakes in Minnesota. My suggestion is to go when the weather is nice, pack a lunch, your swimsuit, and don’t forget your binoculars!
Lake Pepin is part of the Mississippi River and sits right between Wisconsin and Minnesota. When you first drive into town on HWY 61 it will be impossible to miss and on a clear day you will see many white clad sailboats drifting through its waters. My recommendation is to park right by the lake in one of the public parking lots. That way you can easily walk to the beach or the downtown area. My favorite area is the Ohuta Park where you will find a few picnic tables on the beach. Set up your picnic lunch, take a quick dip in the lake, and enjoy the breathtaking backdrop.
Lake Pepin sits on what is known as the “Mississippi Flyway” which is a migration route most notably taken by bald eagles and golden eagles. On any given day you will be able to view scores of these majestic birds fishing in and flying over Lake Pepin. Also, there are several viewing areas set up in and around Lake City where you can learn more about the birds while having a prime view of them soaring overhead.
Who needs “Nessie” when you have “Pepie”?
Legend has it that something very big and ancient lurks in the depths of Lake Pepin and his (or her) name is “Pepie”. There have been several sightings over the years and the Lake City Tourism Bureau is currently offering a 50,000 dollar reward for unquestionable proof of Pepie’s existence. So make sure to have your camera charged and your binoculars on hand to skim the surface for this mysterious beast. You never know who/what might pop up to say hello!
Dining in Lake City
If you’re looking for a sit down dinner or lunch there are numerous restaurants to choose from. Chickadee Cottage Café is right down town and is a warm and inviting place with excellent food and an easy walk from the lake. Skyline offers a wide variety of menu items sure to please everyone. Eat your meal while enjoying the beautiful view of Lake Pepin. If you’re craving a taste of hometown make sure to stop at the Galley Restaurant also located conveniently downtown. If you make your trip on a Friday and don’t mind taking a short five minute drive out of town, head north on HWY 61 to the town of Frontenac where you will find the Whistle Stop Café. It’s a small eatery that has one of the best deals of all-you-can-eat cod dinners around. Go early, the tables fill up fast!
The next time you are looking to take a break from city life for a day make sure to put Lake City, MN on your list of places to stop. It’s a place to have fun and relax while enjoying the lake and surrounding area. From bird watching to Lake Monster searching, Lake City is sure to entertain people of all ages!
Pepie’s Home Page

domain: travel


Army called out, curfew imposed in Bhaderwah town
Authorities imposed curfew and called out the Army on Thursday following clashes in Jammu and Kashmir's Bhaderwah town in Doda district.
Jammu:Authorities imposed curfew and called out the Army on Thursday following clashes in Jammu and Kashmir's Bhaderwah town in Doda district.
Official sources said the clashes broke out between two groups of people following the murder of a Bhaderwah resident, Nayeem Shah, early in the morning by unknown assailants.
Shah's body was recovered by police in Nalthi Pul area of the town.
Authorities called out the Army to assist the civil administration maintain calm in the town. Officials said the curfew will remain in force till further orders.
Police are investigating the civilian's murder and authorities have appealed to people to maintain communal harmony.
- Surgeons remove 8 Spoons, Knife, 2 Toothbrushes from a Man's stomach
- Charge sheet filed against accused in Bandipora rape case
- Muslim family in UP names newly-born son after PM Narendra Modi
- Drought situation in Maharashtra is very serious says Sharad Pawar
- Lok Sabha elections: Five legislators among 248 lose deposit in Punjab, AAP worst hit


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Kirstin May and Lucy Williams talk about the difficulties SAS and LE doctors face in the workplace and what can be done to overcome them
A recent survey by the General Medical Council found that 30% of Specialty and Associate Specialist (SAS) and 23% of Local Employed (LE) doctors have been bullied, undermined, or harassed in the workplace in the past year. This was the GMC’s first ever survey in to these roles. It was undertaken due to the increasing number of doctors in such roles. The report’s initial findings make for a sobering read.
The expertise and contributions offered by this staff group should not be underestimated, especially at a time of workforce shortages. 83% of these doctors have been practising for more than 15 years. Sadly, many of the 6,400 respondents have experienced difficulty accessing training to maintain skills, let alone advance their career. Overall, there is insufficient support related to wellbeing, appraisal, and revalidation.
It is clear that SAS and LE doctors contribute more than pure clinical service. More than 90% undertake additional activities, ranging from teaching, research and clinical governance, to appraising other doctors. The majority are involved in training others, but overall receive less support from employers than consultant trainers.
We are both SAS doctors and we know all too well that complaints of SAS and LE doctors being treated poorly in the workplace are not new. Similar results have been published in other surveys conducted by the BMA. As a group SAS and LE doctors are significantly less likely to find that their workplace is supportive compared to other staff groups. They are less clear about where to take concerns, including concerns about bullying, undermining treatment and harassment.
We all wish to belong and to be part of a team. A feeling of security, support, and a sense of inclusion contributes to a shared vision, which in turn increases wellbeing and productivity. Workplace behaviour and human interactions have an impact on clinical decision making and patient outcomes.
So, how should you treat your SAS and LE colleagues and what does a satisfying career in this role look like? The answer is simple: treat your SAS colleague as you would wish to be treated. We may be working together for many years, so make an effort to get to know us. Include us in departmental business meetings and social events. It is important we are seen to work together, not just alongside each other at the same hospital. When asking “how are you?” in the morning, be interested in your colleague’s answer.
The majority of SAS and LE doctors obtained their primary medical qualification abroad, which may be reflected in cultural differences. Rather than seeing this as a nuisance, be interested in how other cultures behave, socially and professionally, and enjoy the diversity. Moving country and culture is an intensely stressful undertaking, so be prepared to be supportive, not just in relation to work, but also to help colleagues integrate into local life outside work. If there are real or perceived difficulties, be open about them. Discuss, don’t judge.
Professionally speaking, SAS and LE roles are dominated by service commitments, but there needs to be a sustainable balance between regular daytime commitments and night or weekend work. With ever increasing pressure to fill rota gaps and difficulty recruiting, it is all too tempting to ask SAS and LE doctors to work mostly out of hours, but please don’t pressure us into unsustainable working patterns that you wouldn’t use for other staff groups.
Regular commitments and the chance to develop a special interest help us to develop stable professional relationships with colleagues in our own and other specialities. Outside of training grades we all share the same requirements for appraisal and revalidation and hence have the same needs for professional development. Supporting professional activities (SPA) time for revalidation should be non-discriminatory. We all need to participate in clinical governance, morbidity and mortality meetings and continuous professional development, so please share the burden of clinical work equally with us, so we also get a chance to contribute to this.
Will SAS and LE doctors ever be truly treated in the same way as other senior staff? Our personal experience as full council members at the Royal College of Anaesthetists shows they can. We have been given the chance to contribute and lead. An equal voice, equal rights, equal workload, and equal responsibilities are all possible. There is plenty of room to develop and grow personally when given the opportunity.
And to all the SAS and LE doctors out there, we would recommend grasping opportunities as they arise. If there is something you wish to do which is offered to consultants, question whether it could be you instead or as well. Be a team member and pursue the common goal. If a door seems closed try and open it to peep through the gap—you may be surprised what you find on the other side.
Kirstin May is an associate specialist in anaesthetics at Horton Hospital Banbury, Oxford University Hospitals NHS Foundation Trust. She also a council member at the Royal College of Anaesthetists and sits on the RCoA SAS committee.
Lucy Williams is an associate specialist in anaesthetics and pain medicine at Great Western Hospital, Swindon. She also a council member at the Royal College of Anaesthetists and sits on the RCoA SAS committee.
Competing interests: None declared.

domain: medical


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Sophomore forward Andre Roberson is becoming a double-double machine.
On Monday night at the Coors Events Center, Roberson recorded 15 points and 15 rebounds helping the men’s basketball team win 70-68 against the Georgia Bulldogs. It marks his third double-double of the young season.
Freshman guard Spencer Dinwiddie led the Buffs in scoring with 16 points, while fellow freshman Askia Booker contributed a career-best 14 points and added four rebounds.
“That was a great win for our program, especially where we are in the development stages right now,” Boyle said in a post-game press conference. “It wasn’t pretty and it wasn’t easy … but I was really pleased with our team performance.”
Georgia started the first half strong, gaining a 13-9 lead with 12:28 left in the half. The Bulldogs increased that gap to 14-26 before the Buffs started to fight back. A five point run by Roberson brought the score within seven, and with 3:08 left in the half, leading scorer Carlon Brown hit a trey to tie the game at 30-30.
Though the Bulldogs edged their way back into the lead by the half, Booker and sophomore center Shane Harris-Tunks scored a pair of field goals to keep the halftime score close at 34-38.
In the second half, though, the Bulldogs’ energy started flagging. The Buffs took advantage of the Rocky Mountain altitude and began pulling ahead with a 9-1 run in the first four minutes, going up 45-39.
“I think your form isn’t always the same when you’re tired … so I could tell they were fatigued,” Booker said at the press conference. “They were trying to use their bench, but if the bench isn’t prepared it wears on you a little bit.”
UGA managed a quick rally, tying the score at 45-45 with 11:11 left in the game. When Booker came off the bench, though, he lit a spark for CU.
“That’s my role, to come off the bench and spark the team as soon as possible, as fast as I can,” Booker said at the press conference. “That got us going a little faster and got us into our motion a little bit more.”
Booker scored seven points in one minute to bring the Buffs to a 52-47 lead with ten minutes remaining. Colorado then widened that lead to 11 with 2:52 left on the clock. Georgia continued to push back, bringing the score to 68-64 with just 10.4 seconds left.
In those final seconds, the desperate Bulldogs gave Colorado the free throws they needed. Despite two Georgia layups, a free-throw point each by senior Nate Tomlinson and Booker gave the Buffs the final edge and the 70-68 victory.
The Buffs had three players — Dinwiddie, Roberson and Booker — score in double figures against UGA, and they committed only seven turnovers as a team. Roberson said statistics like those show the wide range of talent on the team this season.
“Everybody can play a significant role on this team,” Roberson said at the post-game press conference. “I feel like we’re pretty deep and can go far.”
Boyle said he was especially impressed with freshmen standouts Booker and Dinwiddie, who hit a combined 13 of their 16 free throws.
“The thing I love about Spencer [Dinwiddie] is he has such a belief in himself, and I love how he came out aggressive tonight,” Boyle said at the press conference. “Askia [Booker] is an energizer bunny for this team. He is an essential guy to bring off the bench, and he plays with such reckless abandon and energy.”
With the win, the Buffs improve to 4-2 overall and continue their 26-game non-conference winning streak at home. The Bulldogs’ record drops to 4-3.
The Buffs have just one day to recover before taking on in-state rival Colorado State in Fort Collins on Wednesday at 6 p.m.
“If we can take care of business [vs. CSU] and come out of there with a win, the schedule lines up for this team,” Boyle said at the press conference. “CSU has a scrappy, competitive bunch of kids … but it’s going to be a great challenge.”
Contact CU Independent Staff Writer Caryn Maconi at Caryn.firstname.lastname@example.org.
Photo Credit: CU Independent/Elaine Cromie


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Hin Yai Pinnacle Divers Exploring The Thai Gulf26/07/2015
Scuba Dive Similan Islands Thailand14/06/2016
Where Is Tenggol!? Thats What I Said!
Go diving Tenggol if you are definitely looking for a lost paradise and possibly the best diving and snorkeling in east Malaysia.
Pulau Tenggol or Tenggol Island as it is known, may as well be Jurassic Park!
First of all, Tenggol can be found as the last island off the coast of Terengganu in a line of islands that include Pulau Perhentian and Pulau Redang. Secondly, it's only a tiny small island connected by ferry to Dungun close to Terengganu. While Tenggol island is a protected national park it is largely unvisited, internationally at least. Finding thi splace was lucky! Given that it's so small, it boasts an impressive 26 scuba diving sites and many snorkeling spots. However, Tenggol's season's only runs from march to around the first week of November and then closes as the monsoon season sets in and the waters become simply too choppy for the dive boats. From afar the island resembles a person perching
'Tenggak' in Bahasa Malaysia means 'to perch' but is pronounced as 'tenggol' in Terengganu's local dialect. For many, many years this deserted island retained its secret whereabouts. Apart from local fishermen waiting out the weather - Pulau Tenggol was pretty much left to nature.
Tenggol Island AKA Jurassic Park!
About Tenggol Island
Pulau Tenggol is approx 3km long and only 2km across at the widest point. While all the resorts reside on one side of the island, the main beach area of Tenggol bay is truly beautiful. The beach is pristine with soft white powdered sands and the coral reef grows vibrantly just 20m from where the waves lap at your feet, this beautiful reef is very shallow making it perfect for snorkeling and then is quickly banks down into the deep right inside the bay where scuba divers can descend down to 18m with ease and deeper.
Down in the deeper waters of Tenggol bay more reefs and soft coral outcrops can be found as well as three house wreck dives, 1) The Fisherman's Wreck, 2) The Sawadee Wreck and #) The Vietnamese Wreck . Not 10min by boat more wreck diving can be found at 5 sisters Wrecks which were sank and an artificial reef project, however this site has taken its toll from the monsoon weather and the wrecks are slowly breaking up.
Tenggol Aquatic Life
In Fact, Tenggol is a national park. The protected aquatic life is healthy and plentiful. When Diving in Tenggol you can observe the full spectrum of aquatic life from the tiniest micro organisms such as shrimp and nudibranch in addition to seeing large schools of happy fish thriving from the reefs.
The diversity of fish is amazing such as: Angel fish, Trigger fish, Travally, Puffers, Jacks, chubs and porgy’s with baby and adult barracuda alike. Hiding amongst the reefs are Butterfly fish, squirrel fish, parrot fish, wrasse and damsels within every little coral head. The eco system here support a lot of larger pelagic life also such as Big Rays, Sharks and its famous Whale sharks!
Tenggol Dive Sites
Officially 26 Dives sites
( although more are unlisted) It's hard to believe how easy it was to get to the dive spots. You can make shore or boat diving in Tenggol, although boat dives are really where its at. Scuba divers can choose their type of diving, ranging from the calm and relaxing shallow reefs of Tenggol bay in addition to more demanding deeper drift diving sites. Equally If you like to fly along
with an adrenaline rush and glide effortlessly through clear deep blue waters, then tenggol serves to please. namely Amazing grace
and also Mini highway
are famous for the drift. By the same token, dive sites such as "Tokong Timur" and "Tokong Laut" indeed tick the current box as well at times, yet are explicitly different dive experiences and without doubt are what you are looking for! Pelagic life prevails here. Tenggols famous for it Whale Sharks, namely at these two dive sites! If you are hunting out an experience
with the bigger fish of the oceans you’ll be pleased to know that Pulau Tenggol has plenty of them! Given that the whale sharks migratory route (August to October every year.) runs right past Tenggol island, their presence is frequently anticipated by divers! In 3 weeks I had six encounters! Thats not too shabby! Not many places in the world you can get this kind of frequency.
Tenggol Island Dive Sites Map
Whats Lurking In The Deep?
The waters of Tenggol run deep, I always ponder whats down there off the beaten tracks of the reef lines. On a number of deeper exploration dives I found many more reefs and soft coral outcrops. Within the bay itself there are two house wreck dives, 1) The Fisherman's Wreck, 2) The Sawadee Wreck but with navigation skills and the right guide you can find the Vietnamese Wrecks which there are 3 of them laying next to each other. No more than mins by boat from the beach, even more wreck diving can be found at 5 Sisters Wrecks which were sank and an artificial reef project, however this site has taken its toll from the monsoon weather and the wrecks are slowly breaking up not to mention lay in 35m of water so experienced and advanced deep divers only get the pleasure of exploring these.
Tenggol Island Has Marine Diversity!
The surroundings dive sites of Pulau Tenggol are so rich and diverse in marine life and coral haven that they also support a lot of other larger aquatic life such as Sharks, Giant humphead parrot fish, giant barracuda, giant morays as well as big eagle rays. If you are an underwater photographer these dive sites will really keep you busy, especially "Tanjung Api" where Nudibranch are everywhere!
Here's a Selection Of Our Underwater Photography
From Diving Koh Tao, Enjoy!
Have your Dived Tenggol Island? Did You Meet Their Famous Pet Whaleshark?
Share Your Experiences, Tips and Memories Right Here in a Comment!


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Florida: Weekly Sales Report Medical Marijuana
How much legal medical marijuana flower was sold last week in Florida to qualifying patients?
As displayed in the chart below, Floridians have accepted cannabis as part of their personal health care routines.
From October 4th - 10th, Florida’s medical marijuana patients purchased over 12,951 ounces of flower.
When one considers the last 80 years of cannabis prohibitions this can be viewed as a Renaissance of sorts for America’s approach to health care choices - as well as law enforcement priorities.
Our team salutes the patients and professionals across the Sunshine State as cannabis care returns to America’s heritage with new busineseses and careers created for the local workforce.