text: About a hundred years ago, Henze discovered high levels of vanadium in the blood (coelomic) cells of an ascidian collected from the Bay of Naples. The intracellular vanadium concentration of some species in the family Ascidiidae can be as high as 350 mM, which is 107 times the concentration in seawater. Vanadium ions, thought to be present in the +5 oxidation state in seawater, are reduced to the +3 oxidation state via the +4 oxidation state and are stored in the vacuole of vanadocytes, the vanadium-containing cells, where high levels of protons and sulfate are also contained. To investigate this unusual phenomenon, we have isolated many proteins and genes that might be involved in the accumulation and reduction of vanadium. To date, more than five types of vanadium-binding protein, designated as Vanabin family, have been isolated from vanadocytes. In addition, four types of enzyme related to the pentose phosphate pathway that produces NADPH were revealed to be located in vanadocytes, and NADPH produced by the pentose phosphate pathway participates in the reduction of vanadium(V) to vanadium(IV). Vacuolar-type H +-ATPase (V-ATPase) maintains the low pH in the vacuole and is thought to provide the energy for vanadium accumulation. Using an immobilized metal-affinity chromatography (IMAC) and gene homology cloning, we have further obtained a Vanabin homologue in blood plasma, metalATPase, glutathione-S- transferase and SO4-2 transporter. Now, it becomes important to elucidate not only physiological roles of these proteins but also to resolve how these proteins share their roles to accumulate vanadium in ascidians.


text:
Local companies involved in Manufacturing Day
Thursday, September 19, 2013
The Windsor Star/Dave Hall
Three Windsor-area companies are opening their doors to students on Friday, Oct. 4 to promote manufacturing as a career.
Reko International Group, Radix Inc. and Platinum Tool Technologies are all part of a Manufacturing Day initiative which will see similar tours conducted in more than 500 locations across North America. "The goal is to educate more students about manufacturing as a career and our team here at Reko sees it an a great opportunity to showcase our operations," said Reko CEO Diane Reko. "We've put together a pair of 45-minute tours which won't disrupt operations or create any safety or proprietary concerns. So we're looking forward to it.
"I think it's a great opportunity to get some students into our plant and show them what manufacturing is all about today," said Reko. "The days of old-school tool-and-die shops have past and I think many students will be amazed at the level of computerization in today's manufacturing plants."
The initiative is supported across North America by the Fabricators and Manufacturers Association, the National Association of Manufacturers, the Manufacturing Extension Partnership, the Manufacturing Institute, Industrial Strength Manufacturing and the Science Channel.
"Attracting people to skilled trades and manufacturing has been a real challenge since before the recession hit. And the speed at which baby boomers in that sector are retiring means this will be a decades long problem," said Pat Lee, director of marketing for the Fabricators association.
"This rush to retirement will not slow down so our initiative hopefully will give students an opportunity to see first-hand what manufacturing is about rather than relying upon what they hear and what they read," said Lee. "This is not a dirty, dangerous, dark business anymore and the proof is there to see."
For Radix, it will be an opportunity to show off its new building at 5140 8th Concession, a move which will be completed five days before the tours begin. "I never get tired of telling people we hire engineers, programmers and software developers and that it's a highly specialized field we operate in," said Shelly Fellows, a partner at Radix. "This will give us an opportunity to show people exactly what we do."
The involvement of Windsor-area companies is being coordinated by Michelle Beemer, a career pathway educator at Workforce Windsor Essex.
"It's a way for these companies to communicate directly with students and for students to see exactly what today's manufacturing plants look like," said Beemer. "We've worked with the public and Catholic school boards to put together groups for these tours and they came on board very enthusiastically."
Beemer said that two more local companies are in the process of joining the initiative as well: A.V. Gauge and Fixture and Electromac Group.
Ed Kotevich, Ontario Youth Apprenticeship Program coordinator for the Greater Essex County District School Board, said the program is a "great way to introduce students to manufacturing.
"We're taking this opportunity to try and expand our range and reach an entirely new set of potential manufacturing candidates," said Kotevich.

domain: news


text:
Purchasing a family dental insurance plan gives you and your family two significant benefits:
Better oral health for your family because so many programs pay a large number of the preventive service expenses such as cleaning every 6 months. This encourages the household to see the dentist for regular examinations and washing treatments. Prevention is half the battle!
Generate more savings as the dental insurance carrier pays a specific percentage of dental services for major and minor processes.
Listed below are six questions to steer you in the choice of the proper dental insurance plan for you and your household.
1. Does the plan allow you to choose your own dentist?
Some dental insurance companies give you greater reduced charges provided you use their network of dentists. If your favorite dentist isn't section of the system, the dental insurance policy may not address the procedure. You should think about paying extra for an agenda, that allows you and your family to go to your chosen dentist.
2. Is there rules when it comes to finding the right treatment plans? Some insurance plans put a limit on the number of solutions or control the quantity taken care of an ailment. Then you should choose a plan that's several restrictions on this part, if you or your loved ones has a history of poor dental health care.
3. What is does the plan cover? A perfect dental insurance plan allows for one cleaning treatment every six months, with X-ray and fluoride treatments which come at little or no charge for each member. For the important processes, some dental plans require you to pay 50 % of the complete bill. If your household has a history of good dental health care, you might want to negotiate for lesser coverage when it comes to the important procedures.
4. Which family members are included in the family insurance coverage? Many dental insurance companies protect the spouse and dependent kiddies, from birth through 18. Some exceptions receive for children as much as the ages of 22 if the son or daughter is just a regular student, and dependent on the key for support.
5. Will there be built in flexibility in scheduling dental appointments? When you're able to are available in for dental treatment some affordable dental insurance plans limit. Check to ensure that these scheduled visits do not trouble you or your loved ones.
6. Simply how much savings does this plan of action create? Whether your better half and you decide to purchase a household dental insurance plan, or avail of your businesses sponsored plan you'll still be in a position to generate savings, for you're not paying for the entire process. elk grove dentist

domain: finance


text:
The R&A keeps rewriting the Open Championship exemption rules for Tom Watson, and it's a great thing.
The governing body announced Tuesday it would be offering the five-time champion Watson an extension on his champion's exemption which will allow him to play in the 2015 Open Championship at the Old Course at St. Andrews.
“Some of my finest memories in golf have come from playing in The Open Championship,” said Watson. “I am very proud and honored to be given this opportunity to play once again in St Andrews next year. It is a special place for everyone in golf and I am very much looking forward to playing there again in front of the wonderful Scottish galleries."
The appearance will be Watson's 37th in the Open Championship and also mark the 40th anniversary of his first time playing in the game's oldest major. Watson won the 1975 Open Championship at Carnoustie, defeating Jack Newton in an 18-hole playoff. He would later win in '77 at Turnberry against Jack Nicklaus in the "Duel in the Sun," then again three more times in '80, '82 and '83.
Watson nearly won the Open Championship at Turnberry in 2009, losing in a playoff to Stewart Cink in a bid to become the oldest major champion in history at age 59.
Changes to the Open Championship exemption criteria limit a past champion to being exempt until they turn 60 years of age -- that is unless said champion finishes in the top 10 in an Open Championship in the prior five years. It was a category created for Watson, who would have lost his exemption otherwise despite coming so close to winning a sixth Claret Jug in '09.


An issue in the trial is whether the bullet recovered from Travis Alexander’s cheek was hollow point. This is significant, as the ammunition stolen in Yreka was reported to be hollow point, suggesting Jodi didn’t stage a burglary to obtain a gun.
From the penalty retrial:
“Oh, one more thing, Detective: the shell casing there — it’s not a hollow point is it?” Nurmi asks. Flores answers, “Can’t tell.”


text:
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Special Effects Presentation
Transcript of Special Effects Presentation
that used many new techniques. Zero-
gravity scenes used hidden wires, mirror shots,
and large scale rotating sets. Scenes with spaceships
used hand drawn rotoscopes and motion-control work. CGI (computer generated imagery)
is a revoultionary technique in modern films.
It is used to create complex visuals (by equations in a computer) that can't be filmed. It is also used to mash animated figures and
real live action in the same scene. It has also reduced the need for expensive sets or props. Animators at Disney use
a mult-plane camera to
create a parallex effect for
background depth. In Star Wars a camera controlled by
computers was used to simplify travelling-
matte compositing. A process called tweening
is used to fill in inbetween
frames by using math-
matical algorithims. To create "movement," images
are displayed on computer screens
and are continually replaced by a
different image. The earliest examples of special effects in film
appeared in the 1920's and 30's. During this era,
simple techniques such as rear projection and
stop tricks were refined. The use of 3-d models in the 1933 film King Kong also represented an advancement in film special effects. More widespread use of animation and other effects caused in-house special effects departments to be created. Another advancement in special effects came during the 1960's science fiction boom. Methods such as rotoscoping and front projection were also created. Due to the increasing dependance on effects, the first specialized effects companies were founded in the 70's. Depicting the use of a matte shot An example of the brilliant visuals of CGI The creation of a CGI scene using
actual actors wearing a specially made suit
that records their movements and facial features and then transfers these actions to their CGI character Film Vocab Composite- To combine images that have been shot separately into one shot, either digitally or with a camera, using travelling mattes or by some other means. The resulting image becomes the composite or composite shot. Creature Effects- Creature effects are the creation of a character’s appearance through the use of prosthetics and makeup Digital Effects- Digital effects are the changing or manipulation of shots taken from a live camera. Mechanical Effects- Is the use of mechanized props, scenery, pyrotechnics and scale-models to create a shot on a live action camera. In-Camera Effect- A visual effect that is achieved within the camera prior to developing the film. It usually relies on blocking part of the lens with matte, filming a shot, and then rewinding the film, blocking the previously unblocked part and filming a different element. When developed the two elements will be combined into one shot of the film. Matte Shot- Is a shot that covers part of the lens while having the rest of the shot visible, then going back and covering the previously uncovered area while filming the previously covered area. The two shots are then combined into a third shot to depict them both. Slow Motion- Is the filming of a scene at an extremely fast rate and then playing the scene back at regular speed which gives the viewer the impression that time is moving slowly. Fun Facts R2-D2 was played both by a little person actor (Kenny Baker) and a remote control robot The home of Luke Skywalker is filmed in a traditional underground home in Tunisia • The ancient ruins of Tikal in modern Guatemala were used as the scenery at the rebel base • Linguist Paul Frommer created the language for the Avatars using sounds from the Ethiopian language, Amharic and Maori from New Zealand • Set designers met with Jodie S. Holt, a professor of plant physiology at University of California Riverside, to help best depict the idea of plants communicating with other plants on Pandora • Director James Cameron used a special camera to capture the facial movements of the actors so that these movements could be transferred to the animation of the Computer Generated Imagery characters TRIVIA!!! Which Country was the home of Luke Skywalker filmed in? Tunisia How many R2-D2s were there in Episode IV? Two What modern country was the rebel base in Episode IV filmed in? Guatemala MAGIC!! Just Kidding. Just making sure you were paying attention.

domain: artistic


THEATER WATCH : Foreign Aid
Once, Americans laughed at how seriously the French art world took our animated cartoons. Now Americans too collect cels and argue the fine points of animation. Foreign enthusiasm can sometimes be crucial to the health of a native tradition.
Thursday through Sunday Los Angeles welcomes the great Kabuki actor Baiko Onoe VII to the Japan America Theatre. As Sam Jameson reported Tuesday, this visit will include a reunion between Baiko, one of Japan’s “living treasures,” and Faubion Bowers, an American whom Baiko regards as the savior of this medieval dramatic tradition.
Revenge and valor are central themes in Kabuki; the same, of course, can be said of many of Shakespeare’s works. But who knew enough to make this point in 1945? Back then, to the U.S. occupying force under Gen. Douglas A. MacArthur, Japan was an extremely foreign country.
To persuade the Americans that these highly stylized plays were no threat to security, Bowers had to translate some of them into English. No mean feat: Kabuki is, in fact, far less comprehensible to the average Japanese audience than “Macbeth” to the average American audience. Modern Japanese wear earphones and hear simultaneous translations as they view it.
Fortunately, Bowers’ tactics worked. His foreigner’s enthusiasm for Kabuki, dating to well before the war, both removed American suspicions and restored Japanese confidence. We welcome Faubion Bowers, who will be visiting from New York, as well as Baiko Onoe VII. Rarely has any drama critic done so great a service to drama.


text: All the messages about how fantastic roasted vegetables can be inspired me at the grocery store yesterday to try doing it with brussel sprouts. Anyone have any tips? Do I just trim off the ends and cut them in half? A bit of olive oil and some s&p? How long in the oven? Thanks for any and all advice.

domain: food


text:
Marie Nguyen is the co-founder of WeDressFair.
She is an engineer in cancer research, and has always sought to have an impact on the world around her.
It was by being a volunteer in associations fighting against social exclusion that she entered the world of textiles. Discovering the enormous social and environmental impact of the fashion industry, she wanted to do her part.
WeDressFair is an online website that highlights only fashion brands that respect people and the environment. Listing more than 100 brands, WeDressFair wants to make it easy for all consumers to find an attractive alternative in fashion.

domain: sociology


text:
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text:
Our outside world changes continuously, for example, when driving through traffic. An important question is how our brain deals with this constant barrage of rapidly changing sensory input and flexibly selects only newly goal-relevant information for further capacity-limited processing in working memory. The challenge our brain faces is experimentally captured by the attentional blink (AB): an impairment in detecting the second of two target stimuli presented in close temporal proximity among distracters. Many theories have been proposed to explain this deficit in processing goal-relevant information, with some attributing the AB to capacity limitations related to encoding of the first target and others assigning a critical role to on-line selection mechanisms that control access to working memory. The current study examined the role of striatal dopamine in the AB, given its known role in regulating the contents of working memory. Specifically, participants performed an AB task and their basal level of dopamine D2-like receptor binding was measured using PET and [F-18]fallypride. As predicted, individual differences analyses showed that greater D2-like receptor binding in the striatum was associated with a larger AB, implicating striatal dopamine and mechanisms that control access to working memory in the AB. Specifically, we propose that striatal dopamine may determine the AB by regulating the threshold for working memory updating, providing a testable physiological basis for this deficit in gating rapidly changing visual information. A challenge for current models of the AB lies in connecting more directly to these neurobiological data.
In an ever-changing world, our senses are continuously bombarded with more information than our brain can process up to the level of awareness. Hence, the ability to rapidly select goal-relevant information when it occurs and inhibit irrelevant or distracting information is central to goal-directed behavior. The challenge our brain faces when presented with an overwhelming amount of information to analyze is captured by one of the most studied attentional phenomena in the literature: the so-called attentional blink (AB) deficit (Raymond, Shapiro, & Arnell, 1992). This deficit occurs when people have to detect two target stimuli (T1 and T2) presented in close temporal succession and among distracter events. Specifically, when T2 follows T1 within 100–500 msec, it often goes unnoticed. Different models have been proposed to explain this deficit in selective information processing, with many early models attributing the AB to limitations in processing capacity (Shapiro, Raymond, & Arnell, 1997). The general idea underlying these models (e.g., Chun & Potter, 1995) is that, to become available for conscious report, a stimulus has to be encoded and consolidated in working memory, a process that is assumed to consume limited processing recourses. If these resources are allocated to consolidation of T1, fewer resources are available for T2, rendering the sensory representation of T2 more susceptible to decay and interruption by distracters, so that T2 is less likely to be maintained and reported later.
Yet, limited-capacity models have difficulty explaining recent behavioral findings showing that individuals can easily process up to four targets presented in close temporal proximity, as long as there is no intervening distracter stimulus (Di Lollo, Kawahara, Shahab Ghorashi, & Enns, 2005). This observation, as well as others (e.g., Olivers, van der Stigchel, & Hulleman, 2007; Kawahara, Kumada, & Di Lollo, 2006), have stimulated the development of novel theories that posit that the AB results from on-line selection mechanisms that act in response to distracting input rather than being the result of T1-induced cognitive resource depletion (for recent reviews, see Martens & Wyble, 2010; Dux & Marois, 2009). For example, it has been postulated that individuals apply an attentional set (or filter) for targets and against distracters and that the AB results from disruption of the input control filter by T1 processing (Di Lollo et al., 2005) or an inhibitory response meant to suppress D1, but which accidentally suppresses the subsequently presented T2 (Olivers & Meeter, 2008).
Thus far, the majority of AB accounts make inferences about the exact processes that contribute to the AB solely based on the indirect measure of performance. Studies examining the neurobiological mechanisms underlying the AB may provide additional information critical for understanding this deficit in gating rapidly changing visual information. The current study examined the role of striatal dopamine in the AB given its known role in controlling information flow into working memory (e.g., Cools & D'Esposito, 2011; Frank, Loughry, & O'Reilly, 2001; Braver & Cohen, 1999). Many AB theories emphasize the importance of working memory for consolidating target information (Martens & Wyble, 2010; Dux & Marois, 2009). Indeed, behavioral work has shown that the size of the AB is related to operating resources within working memory, including one's ability to keep irrelevant information out of working memory (Arnell, Stokes, MacLean, & Gicante, 2010; Arnell & Stubitz, 2010; Martens & Valchev, 2009; Dux & Marois, 2008; Colzato, Spapé, Pannebakker, & Hommel, 2007). Notably, a large body of research has linked working memory operations to interactions between the striatum and frontal cortex and has revealed a critical role for the neurotransmitter dopamine in regulating these interactions. In particular, whereas frontal dopamine appears critical for maintaining working memory representations and thus stability of behavior, striatal dopamine is thought to be critical for the updating of frontal working memory representations and hence, flexibility of behavior (e.g., Cools & D'Esposito, 2011; Frank et al., 2001; Braver & Cohen, 1999). Indeed, striatal dopamine has been shown to promote cognitive flexibility by allowing updating of newly relevant representations in working memory and preventing gating of nonrelevant representations (e.g., Wang, Vijayraghavan, & Goldman-Rakic, 2004; Frank et al., 2001). On the basis of this work, we previously hypothesized that striatal dopamine may play an important role in the AB by regulating which stimuli enter working memory (Colzato, Slagter, de Rover, & Hommel, 2011; Colzato, Slagter, Spapé, & Hommel, 2008). Consistent with this hypothesis, we found that individual AB size is predicted by spontaneous eye blink rate, a marker of striatal dopaminergic functioning (Karson, 1983), and by the C957T polymorphism at the DRD2 gene (associated with striatal D2 receptors; Colzato et al., 2008, 2011). These observations provide preliminary, albeit indirect, evidence for a role of striatal dopamine in the AB.
The current study tested the hypothesis that striatal dopamine and in particular striatal D2 receptors play a role in the AB more directly. To this end, participants took part in three sessions: (1) an AB task session, (2) a PET session in which baseline D2-like (D2/D3) receptor availability was measured using the ligand [F-18]fallypride at rest, and (3) an MRI session for anatomical localization purposes. Our main prediction was that individual variation in striatal D2-like receptor binding would predict individual AB size. Notably, D2 receptors are expressed primarily in the striatal indirect pathway (Gerfen, 1992), which is thought to prevent gating of irrelevant representations into working memory (Hazy, Frank, & O'Reilly, 2007a; O'Reilly & Frank, 2006). An association between striatal D2-like receptor binding and AB size would thus indicate that striatal dopaminergic functioning may represent an important neurobiological mechanism underlying distracter suppression efficiency and hence the ability to rapidly and flexibly gate only newly relevant information into working memory for further processing in the AB task.
Fourteen right-handed adults (nine women, 19–29 years, mean age = 20.2 years) participated in this study. Only healthy participants without history of developmental disorders, head trauma, psychiatric or neurological disease, and drug abuse were included. All had normal or corrected-to-normal visual acuity. Participants were asked to abstain from eating, drinking (other than water), and smoking for minimally 4 hr before the PET session. They were compensated for participation. The study was approved by the local ethics committee.
Experimental Design and Procedure
Data were collected in three sessions, separated by 1–4 weeks: a behavioral session, a PET imaging session, and an MRI session.
Participants performed an AB task adopted from Slagter et al. (Slagter, Lutz, Greischar, Nieuwenhuis, & Davidson, 2009; Slagter et al., 2007). They had to identify two digits presented in a rapid stream of letters (Figure 1). Each trial started with a fixation-plus sign (+; 2000 msec). After a blank interval (250 msec), the stimulus stream began, consisting of 20 items, each presented in black on a gray background (red, green, blue: 70, 70, 70) at the center of the screen (16 point Times New Roman) for 67 msec, followed by a 33-msec blank. Each letter was randomly drawn (without replacement) from the alphabet (except I, O, S, and Z). Digits were drawn randomly from the set 1–9. T1 position was varied randomly between 7 and 9. T2 was presented directly thereafter (Lag 1) or after two, four, or seven distracters (at Lags 3, 5, or 8, respectively). Previous work using a highly similar task has shown a large AB at Lag 3 compared with Lag 8 position (Colzato et al., 2008, 2011). Both targets were to be reported 250 msec after the stream by pressing the corresponding digit keys. Participants first practiced the task for 24 trials. Then, they performed two blocks of 48 trials each, resulting in 24 trials per lag condition, all intermixed within blocks.
PET Data Acquisition Session
PET data were acquired using a Siemens EXACT HR+ PET scanner in 3-D mode (septa retracted) and the high-affinity D2/D3 radioligand [F-18]fallypride. Individual differences in D2-like receptor availability as measured by [F-18]fallypride are stable across time (Mukherjee et al., 2002) and thus provide an index of stable individual differences in striatal dopaminergic neurotransmission. [F-18]fallypride expresses the highest affinity for D2 receptors, but also binds to D3 receptors and (albeit weakly) to D4 receptors. The subjects were positioned head first, supine with the cantho-meatal line parallel to the in-plane field of view. The head rests in the scanner head holder extending from the patient bed and held in place by surgical tape placed firmly across the subject's forehead. A 5-min transmission scan was then acquired to correct for the attenuation of the gamma rays within the tissue. The acquisition of the dynamic [F-18]fallypride PET scan was initiated with the injection of radioligand (237 ± 43 MBq). The synthesis of [F-18]fallypride was carried out using previously reported methods (Mukherjee, Yang, Das, & Brown, 1995). The final sterile 0.9% saline solution of [F-18]fallypride was produced with radiochemical purity greater than 95% and specific activity of 227 ± 140 GBq/micromol. A 150-min dynamic acquisition was acquired, initiating with the 30-sec bolus infusion of radiotracer. The time series were binned into six 1-min frames and 48 3-min frames.
MRI Data Acquisition Session
Anatomical brain images were acquired on a 3T-GE Signa scanner, equipped with high-speed gradients and a whole-head transmit–receive quadrature birdcage headcoil (GE Medical Systems). Anatomical scans consisted of a high-resolution 3-D T1-weighted, inversion–recovery fast-gradient-echo image (inversion time = 600 msec, in-plane resolution = 256 × 256, field of view = 240 mm, 124 × 1.1 mm axial slices), and a T2-weighted, fast-spin echo image (in-plane resolution = 256 × 256, field of view = 240 mm, 81 × 2 mm sagittal slices).
Behavioral Data Analysis
T1 and T2 accuracy data were submitted to separate repeated-measures ANOVAs with Lags (1, 3, 5, and 8) as a within-subject factor. T2 accuracy was based only on those trials in which T1 was correctly reported.
Brain Imaging Data Analysis
T1-weighted MRI images were manually masked to exclude nonbrain tissues. These “skull-stripped” images for each participant were coregistered to the MNI-152 template packaged with FSL. The resulting standard-space, skull-stripped T1-weigted MRI images were averaged to create single-participant templates in standard space. Small differences in brain morphology were accounted for by performing a nonlinear warp using FSL's nonlinear registration tool (www.fmrib.ox.ac.uk/analysis/techrep/tr07ja2/tr07ja2.pdf) to align each participant's standard-space skull-stripped T1-weighted MRI images to their single-subject template. These transformations were then combined with the DVR to T1-weighted MRI transforms and applied to the DVR images to create binding images. Because differences observed in across-subject analyses might result from individual differences in brain anatomy (Woodward et al., 2009; Oakes et al., 2007) rather than true differences in binding, we assessed the probability of gray matter (GMP) at each voxel in each participant's brain based on the skull-stripped standard-space T1-weighted MRIs using FSL's automated segmentation tool (Zhang, Brady, & Smith, 2001). Before statistical analyses, all images were blurred using an 8-mm FWHM Gaussian filter to account for potential across participant differences in anatomy.
Our main prediction was that striatal D2-like receptor binding would be predictive of individual differences in AB size, defined as the difference in T2 accuracy between Lag 8 and Lag 3 trials. To examine this prediction, we correlated individual differences in receptor binding with individual differences in AB size (while controlling for GMP at each voxel) using Spearman's rank correlation). Only voxels with an average dopamine binding value of 1.2 or greater (i.e., greater than 1.2 times the cerebellar binding rate) were included in the correlation analysis to exclude most white matter regions. Significance testing was carried out via a two-stage permutation testing (Nichols & Holmes, 2002). At the first stage (voxel level), as a first step, GMP was regressed out of D2-like receptor binding. Then, participant identity was randomly shuffled, and the Spearman's correlation between AB size and the residualized binding values was computed again at each voxel. This was repeated 1,000 times, generating a distribution of correlation coefficients at each voxel under the null hypothesis of no relationship between AB size and D2-like receptor binding (while controlling for GMP). Statistical Z values were taken as the normalized distance of the real correlation coefficient compared with the null distribution. Voxels with a Z value greater than 2.6 (p < .005) were retained as being significant at the voxel level. In the second stage (cluster level), Z values were computed based on one of the 1,000 random permutation iterations, and the statistical map was thresholded again. This time, the number of voxels in the largest suprathreshold cluster was stored. This was repeated 500 times, generating a distribution of maximum cluster sizes under the null hypothesis. The cluster threshold was defined as the standardized distance from the mean of the maximum cluster distribution corresponding to p < .05 (20 contiguous voxels).
As expected and shown in Figure 2, participants exhibited a marked AB, with lower performance at Lag 3 than at Lags 1, 5, and 8 (main effect of Lag: F(3, 39) = 3.6, p = .022). This pattern was confirmed by post hoc polynomial contrasts revealing a significant cubic trend, F(1, 13) = 4.8, p = .046. Furthermore, in line with the literature (e.g., Martens, Munneke, Smid, & Johnson, 2006), there was large variability among participants in the size of the AB, as indexed by the difference in T2 accuracy between Lags 8 and 3. AB size varied across individuals between −7.8% and 40.7%. T1 accuracy did not differ significantly between lags, F(3, 39) < 1, p = .69. T1 accuracy was overall high: 99%, 99%, 100%, and 99% at Lags 1, 3, 5, and 8, respectively.
D2-like Receptor Binding and AB Size
Our main prediction was that individual variation in AB size would be associated with individual variation in striatal D2-like receptor binding, as measured in a separate session using PET and the radioligand [F-18]fallypride during resting conditions. Confirming this prediction, voxel-wise correlation analysis revealed a significant correlation—after correction for GMP—between AB size and D2-like receptor binding in the dorsal striatum, bilaterally and in the vicinity of the caudate nucleus and globus pallidus (Figure 3). More specifically, in both the left and the right striatum, higher binding was associated with a larger AB to T2, as can be seen in Figure 4. This scatter plot displays the correlation between AB size and binding for the voxel showing the highest correlation for each striatal cluster separately. The xyz MNI coordinates of the voxel showing the highest correlation (r(12) = .70, p = .005) within the left striatal cluster were: −16, −2, 18. The right striatal cluster contained two peaks. The xyz MNI coordinates of the first peak (r(12) = .81, p < .001) were 18, −8, 18, and the xyz MNI coordinates of the second peak (r(12) = .71, p = .005) were 20, 12, 12.
In contrast to several other D2 radioligands (e.g., [C-11]raclopride), [F-18]fallypride provides sufficient signal-to-noise ratio to quantify D2-like binding in extrastriatal areas, such as cortex, where the concentration of D2 receptors is much lower than that in the striatum. Yet, no other brain region exhibited a relationship (negative or positive) between AB size and D2-like receptor availability, even at a more lenient voxel-level threshold of p < .01.
In this PET study, we examined the relationship between striatal dopamine, as indexed by baseline D2-like receptor binding, and the AB, a deficit in processing two meaningful events presented in close temporal proximity and among distracter events. As predicted, increased D2-like receptor availability in the striatum was associated with a larger AB to T2. This novel finding supports the idea that striatal dopaminergic neurotransmission; hence, mechanisms involved in dynamically regulating the contents of working memory play an important role in the AB. It corroborates previous, more indirect evidence implicating the striatum, and in particular the striatal D2 pathway, in the AB (Colzato et al., 2008, 2011; Slagter, Johnstone, Beets, & Davidson, 2010).
Increased D2-like receptor binding in the striatum in individuals with a relatively large AB may correspond to higher receptor densities or lower levels of (competing) endogenous dopamine or both. It is notable in this respect that genetic overexpression of striatal D2 receptors in rodents causes impairments in set shifting (Kellendonk et al., 2006). Furthermore, a lower basal level of endogenous striatal dopamine in individuals with a large AB would be in line with our previous observation that these individuals show a relatively low spontaneous eye blink rate (sEBR), an index of striatal dopaminergic function (Colzato et al., 2008; Karson, 1983).
An important question for future research is how precisely striatal dopamine may determine the AB. As mentioned in the Introduction, previous work has shown that high levels of striatal dopamine promote cognitive flexibility by permitting updating of frontal working memory representations, whereas low striatal dopamine levels are associated with cognitive stability and little updating in response to novel relevant information (for recent reviews, see, e.g., Cools & D'Esposito, 2011; Maia & Frank, 2011). Our observation that more D2-like receptor binding (hence, likely a lower level of [competing] endogenous dopamine) was generally associated with a larger AB is in line with the notion that low striatal dopamine levels promote stabilization of frontal task-relevant representations (Cools & D'Esposito, 2011; Maia & Frank, 2011). However, previous research also indicates that excessivly high striatal dopamine levels may impair performance as well, and it has been suggested that the relationship between cognitive performance and striatal dopamine level follows a U-shaped function (summarized in Cools & D'Esposito, 2011), where both too little and too much striatal dopamine can hurt performance due to, respectively, impaired gating and inefficient gating (and contaminant distractibility). Our data, although indicative of a linear relationship, are not inconsisent with a U relationship between D2-like receptor binding and AB size, as it is conceivable that healthy subjects display a relatively restricted range in baseline dopamine level during resting conditions. On the basis of the larger literature on working memory and dopamine, we therefore hypothesize that striatal dopamine more likely exhibits a U relationship with AB size (see Figure 5), such that intermediate tonic dopamine levels promote optimal gating (or selective target updating) and hence a small AB,whereas both excessively low and excessively high tonic dopamine levels produce a large AB, albeit for different reasons. Whereas high dopamine levels will lead to more overall working memory updating and concomitant distractibility and a large AB (i.e., they also induce distracter updating, causing interference in working memory), very low levels will also be associated with a large AB due to a general poor updating ability (not enough dopamine to update even target information). Note that in the latter case in particular (general poor updating ability), one would also expect poor T1 accuracy. In the current study, with healthy individuals and T1 accuracy at ceiling level (99–100%), no relationship between D2-like binding and T1 accuracy was observed. Yet, it is of note that in the study by Colzato et al. (2008), the group of subjects with relatively low sEBR scores not only displayed a larger AB to T2 but also lower T1 accuracy compared with the group of subjects with relatively high sEBR scores. This observation is in line with the idea that low striatal dopamine levels lead to an overall impairment in updating ability. Yet, future research in which dopamine level is experimentally manipulated across a wide range is necessary to determine whether or not the relationship between AB size and dopamine level follows the proposed U-shaped function.
In summary, we hypothesize that striatal dopamine determines the AB by regulating the threshold for working memory updating. In this framework, the AB can be due both to a general poor updating ability, when the threshold for working updating is set too strongly (and striatal dopamine levels are very low), and to distracter interference in working memory, when the threshold for updating is set too lenient (and striatal dopamine levels are very high). This account, which highlights a neurobiological mechanism through which rapid input control might be accomplished, is in line with the notion that the AB results from online selection mechanisms that control information flow into working memory rather than being the result of T1-induced cognitive resource depletion (see also below). Yet, future studies, including pharmacological, patient, and neurocomputational studies, are necessary to determine the precise relationship (i.e., linear or U-shaped) between basal striatal dopamine activity and the ability to gate only newly task-relevant information into working memory under rapidly changing input conditions, such as the AB. This work should also address the relationship between tonic dopamine levels and phasic dopamine responses. Phasic dopamine in the striatum has been related to selective reinforcement of gating for task-relevant stimulation (e.g., Maia & Frank, 2011), and large phasic responses may hence promote selective target updating in the AB task. Future work should also look into the possible role of striatal dopamine receptor features in the AB. As pointed out above, D2-like receptor binding is proportional to both receptor density and endogenous dopamine, and on the basis of the current data alone, it is unclear to what extent the AB may be related to endogenous dopamine level, D2 receptor density, and/or other receptor features, such as affinity. Thus, more research is necessary for fine tuning the “dopamine hypothesis” of the AB and may ultimately lead to a mechanistic and neurobiologically grounded model of the AB.
It is noteworthy that the regions in which D2-like receptor binding predicted AB size fall within the associative striatum. This part of the striatum forms loops with associative regions of the cortex, such as dorsolateral pFC (Draganski et al., 2008; Joel & Weiner, 2000). Notably, PET and fMRI studies have linked the associative striatum to flexible cognitive control, including operations such as working memory updating and inhibition of irrelevant information (e.g., Kühn et al., in press; Bäckman et al., 2011; Dahlin, Neely, Larsson, Bäckman, & Nyberg, 2008; McNab & Klingberg, 2008). Although striatal dopamine has been linked to many functions other than WM gating and our measure, D2-like receptor binding, hence does not provide a pure measure of WM gating, the location of our effects in the associative striatum is in line with our hypothesis that striatal dopamine determines the AB by regulating the threshold for WM updating.
It is of further note that the D2 receptor is expressed primarily in the striatal indirect pathway, which traverses the pallidum and subthalamic nucleus before targeting BG output structures (Gerfen, 1992). It has been posited that the striatum facilitates or suppresses cortical actions (e.g., working memory updating) via separate direct and indirect pathways, respectively, that project to frontal cortex and that the likelihood that a cognitive representation is selected for updating of working memory in the frontal cortex is proportional to the difference between activity for that representation in the direct and indirect pathways (Hazy, Frank, & O'Reilly, 2007b). Indeed, the indirect pathway has previously been shown to play a critical role in filtering out distracting information from being updated into working memory (McNab & Klingberg, 2008; Moustafa, Sherman, & Frank, 2008; Frank & O'Reilly, 2006; O'Reilly & Frank, 2006). Given the critical role of the striatal D2/indirect pathway in inhibiting distracting information, it is notable that recent behavioral studies have shown that individual differences in the ability to inhibit distracting information determine AB size (Arnell & Stubitz, 2010; Martens & Valchev, 2009; Dux & Marois, 2008). In addition, the here-observed relationship between D2-like receptor binding and AB size may thus provide a neurobiological mechanism through which selection mechanisms control responses to distracting input and provide support for filter-based accounts, where the AB reflects the workings of a mechanism designed to filter out nonrelevant information (e.g., Olivers & Meeter, 2008; Di Lollo et al., 2005; Raymond et al., 1992). One of these models (Olivers & Meeter, 2008) actually postulated a possible role for the BG in the AB based on previous findings showing that a prefrontal/BG network regulates access to working memory (McNab & Klingberg, 2008). Yet, our finding could be consistent with models that attribute the AB to the shielding of T1 processing as well (e.g., Taatgen, Juvina, Schipper, Borst, & Martens, 2009; Wyble, Bowman, & Nieuwenstein, 2009; Hommel et al., 2006; Jolicoeur & Dell'Acqua, 1998). By preventing gating of irrelevant representations, striatal D2 receptors may also promote undisturbed consolidation of T1 in working memory. In either case, the observed relationship between D2-like receptor binding and the AB suggests that mechanisms involved in regulating the contents of working memory and in particular mechanisms related to suppressing irrelevant information contribute significantly to this phenomenon. A challenge for current computational and theoretical accounts of the AB lies in connecting more directly with these neurobiological data. Our results also synthesize the AB literature with the largely separate literature associated with working memory and may thus in addition inform models of working memory that have not yet had to confront rapid presentation of stimuli (e.g., Hazy et al., 2007a; Frank et al., 2001) by providing information regarding the timing of mechanisms involved in gating of information.
A role for striatal dopamine in the AB also receives support, albeit more indirectly, from several previous studies. First, as mentioned in the introduction, Colzato and colleagues found that sEBR, a marker of striatal dopamine function (Karson, 1983), predicted individual AB size (Colzato et al., 2008) and, furthermore, that the C957T polymorphism at the DRD2 gene (associated with striatal D2 receptors) was associated with AB size whereas polymorphisms associated with frontal dopamine and norepinephrine were not (Colzato et al., 2011). In addition, people high in WM operation span—a measure associated with striatal dopaminergic activity (Cools, Gibbs, Miyakawa, Jagust, & D'Esposito, 2008)—display a smaller AB (Colzato et al., 2007). Finally, Olivers and Nieuwenhuis (2006) reported a reduced AB when, before trial onset, participants viewed pictures of positive affective content, which are thought to stimulate the dopaminergic system (Ashby, Isen, & Turken, 1999). Using PET imaging, the current data extend these findings by providing more direct evidence for a role of striatal dopamine and, specifically, the indirect striatal pathway in the AB. Future research in which striatal dopamine levels are manipulated pharmacologically is necessary to determine more precisely how striatal dopamine may control gating of rapidly changing visual input.
Yet, it should be noted that it is unlikely that any single neuromodulatory mechanism can explain the many experimental factors that are known to modulate the AB. Other neurotransmitters and in particular norepinephrine, given its role in temporal attention (Aston-Jones & Cohen, 2005), likely also contribute to this phenomenon. For example, whereas striatal dopamine may modulate the threshold for working memory updating, norephinephrine may enhance cortical target processing (Nieuwenhuis, Gilzenrat, Holmes, & Cohen, 2005). Nevertheless, together with previous findings (Colzato et al., 2008, 2011), the current data suggest an important role for striatal dopamine and, specifically, the striatal indirect pathway in the AB and, more generally, in flexibly prioritizing relevant over irrelevant information.
This work was supported by the Netherlands Organization for Scientific Research (NWO VIDI grant to H. A. S., NWO VENI grant to L. S. C.) and a grant from the National Institute of Mental Health (MH43454 to R. J. D.). We thank two anonymous reviewers for their helpful comments.
Reprint requests should be sent to Heleen A. Slagter, Department of Psychology, University of Amsterdam, Weesperplein 4, 1018 XA Amsterdam, the Netherlands, or via e-mail: email@example.com.

domain: literature


text:
A gentle pickle method to preserve cardoons in the fridge. They taste like artichokes, with a much higher yield.
Course: Appetizer, Side Dish
Keyword: A la Grecque, cardoons
Tall stainless steel pot (don't use aluminum)
1cardoonabout 2 lbs
3large cloves garlicsliced
3cupsdry white wine
2teaspoonssea salt or kosher salt
Bouquet garni of 2 fresh bay leaves and a small handful of fresh thymewrapped in cheesecloth and tied together
Water seasoned to taste with lemon juiceas needed for holding the cardoons
Peel the cardoon stalks of their spines and thorns on the side of each stalk using a paring knife, then gently remove the tough outer portion of the stalk, as you would peel celery. Cut the cardoons into ½ inch pieces and place them in the lemon water to prevent browning.
In a large, wide pan, heat the garlic on medium heat until lightly browned and aromatic, then add the cardoons, salt, wine, water, and herbs. Cover and cook for anywhere for 30 min to an hour, or until the cardoons are just tender. Transfer the cardoons to a labeled container, cover with their cooking liquid and weight down with a plate to hold them under the liquid and preserve them. Under their liquid the cardoons will keep for a couple weeks, they can also be frozen.
To serve the cardoons, reheat them with a bit of their juice and use as you would artichokes.
It's important not to leave the cardoons in water overnight after peeling. The water reacts with them and makes them curl, and after having their structure altered from peeling they'll twist and curl into a pile of useless fibers, although they could still be cooked with cream.


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Bjarke Ingels is everywhere. Literally. Three weeks ago, we wrote about his new design for 2 Penn Plaza. Two weeks ago, we wrote about his amazing XI sales gallery experience with the stage designer Es Devlin. Last week, it was his new role as Chief Architect at WeWork. And now, BIG has just announced Bjarke built an off-the-grid triangular tiny house in the Catskills with designer and interior architect Soren Rose. (Does this rockstarchitect ever sleep?) Bjarke Ingels Group shared with 6sqft this exclusive set of photos of the mini modern abode, which blends the A-frame architecture of the upstate area with a Nordic aesthetic.
Architect Tim Seggerman renovated an extended a Brooklyn Brownstone blending Finnish and Japanese aesthetics in a beautiful way. Located in Cobble Hill, this family home was re-conceived in a modern way, respecting its traditional brownstone facade with a surprising extension at the back. Using a variety of wood that includes white oak, mahogany, bamboo, teak and ash, the local architect turned this Brooklyn dwelling into a stylish comfortable place to live.


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domain: entertainment


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Osteoarthritis is a debilitating disease characterized by the swelling of the joints. Sufferers experience great pains and stiffness plus they can even become incapable of active and of performing the simplest movements. Arthritis can take many forms and its causes are not yet clear. Patients must get a physician by all means in order to get an satisfactory joint disease treatment. This disease is a chronic one, so it doesn’t vanish entirely completely.
One can live with it his or hers entire life and the point of arthritis treatments is to offer pain relief also to alleviate the symptoms. Besides approved drugs for arthritis there are also natural treatments that patients can try. Taking man-made pills for the complete life is not at all a pleasurable perspective; this is why many people try natural remedies. Arthritis treatments depending on herbs and essential oils include, Lavender and rosemary essential oil – They have a strong anti-inflammatory and analgesic properties and they provide pain relief if massaged on the painful areas.
Arthritis In Neck And Bone Spurs
What are the main challenges of working with siRNAs? SiRNAs are of short duration and are poorly absorbed by cells without a release system. A peptide-based nanoparticle delivery system protects the siRNA from degradation during circulation in the bloodstream and promotes their uptake into the cell. Does the RA mouse model have limitations? Although the cause of arthritis in this mouse model is different from true RA, the pathways contributing to inflammation and joint damage are still relevant.
The prevalence of scleroderma in adults in the United States is 240 per million. Scleroderma refers to a group of diseases that affect the connective tissue in the body. Scleroderma involves the accumulation of scar tissue in the skin. It also damages the cells lining the walls of small arteries. The cause of scleroderma is currently unknown. However, collagen buildup in the skin and organs is responsible for the symptoms of the disease.
Supportive therapy also involves the management of coexisting conditions such as heart disease, bone disease, lung disease, vasculitis, eye complications, kidney disease, anxiety, and other conditions. and the depressive disorders. Physiotherapy is an important part of treating debilitating arthritis. This helps maintain optimal flexibility and strength of the joints. Pain relief may be offered using heat or ice packs, or Transcutaneous Electrical Nerve Stimulation TENS. TENS uses a machine that applies a small impulse of electricity to the affected joint, which numbs the nerve endings and relieves pain.
Although the symptoms of arthritis vary from person to person, the two most common are stiffness and pain. This is particularly the case with osteoarthritis, which often causes the most intense stiffness after morning wakefulness. 14b The Arthritis Foundation says, “If you experience morning stiffness that lasts more than an hour, that’s a good reason to suspect arthritis. It should not be so difficult or painful to get up from your favorite one “15 Some joints are more often affected by arthritis or osteoarthritis than others, including those found in me.
She is a practicing rheumatologist and researcher whose interests include designing strategies to safely administer nanomedicine for the treatment of inflammatory diseases, with a focus on arthritis. . Contact Dr Christine PhamThe University of Washington Medical School Department of MedicineDivision of Rheumatology660 S. Euclid Ave Campus Box 8045St. Louis, MO 63110USA We build long-term partnerships and collaborate with scientists who want to spread the essence of their work to a diverse global audience.
These can reduce the levels of C-reactive protein CRP in the blood. CRP is a marker of inflammation associated with heart disease, diabetes, and rheumatoid arthritis. The fiber they contain is also useful for nourishing the good bacteria in your belly, which are important for fighting inflammation and boosting immunity. Oleocanthal, a molecule found in olive oil, has anti-inflammatory properties similar to ibuprofen – and may help relieve chronic and acute inflammation associated with ibuprofen.
Juvenile Arthritis Rheumatoid
“It’s a form of mechanically-driven arthritis that increases with age,” says Professor Philip Conaghan, a professor of musculoskeletal medicine at the University of Leeds. “It comes from old wounds, pressure from our work and weight gain over the years, and you end up living an increasingly rare life when you stop getting too much out of it because you are suffering. Rheumatoid arthritis is where the immune system attacks the cells of the joint mucosa, causing pain, stiffness, and swelling.
Free radicals are unstable atoms that can damage cells and kill them. Free radicals accumulate in the body like rust and they are the cause of degenerative diseases and premature aging. Antioxidants are molecules that can prevent cellular damage byEe radicals cause. Antioxidants have anti-aging effects and help prevent cancer, heart disease, eye problems and immune problems.
Adalimumab belongs to a class of drugs called tumor necrosis factor TNF inhibitors. It works by blocking the activity of TNF, a substance in the body that causes swelling and joint damage in rheumatoid arthritis. AnakinraBrand s: KineretAnakinra is used alone or in combination with other medicines to reduce the pain and swelling associated with rheumatoid arthritis. Anakinra is in a class of medications called interleukin antagonists.
But first, let’s take a look at the cause of arthritis. We once thought that arthritis was the result of usury – but more recent research shows that this is not the case. Researchers at Stanford University say that arthritis can be the result of low-grade chronic inflammation. In a nutshell, the immune system releases proteins that damage the joints – and these proteins also bind to the cartilage-producing cells in the joints, causing them to secrete even more damaging protections.
Oral antibiotics are usually used in the treatment of gonococcal infections of the joints. Gonorrhea-infected joints rarely require surgical drainage. Surgical drainage is indicated when one or more of the following effects occur: Routine arthroscopic lavage is rarely indicated. However, drainage through the arthroscope replaces open surgical drainage. With arthroscopic drainage, the operator can visualize the inside of the joint and can drain the adhesions of pus, debridement and lysis.
These include genes encoding cytokines, chemokines, and the inducible cyclooxygenase enzyme. 8 More than 100 active components have been isolated from turmeric, including special substances found in the volatile oils of turmeric called turmerone, curcumin, emulsified Thoxycurcumin, 5-methoxycurcumin and dihydrocurcumin. 9 The most active ingredient in turmeric is curcumin, which is known to be one of the most potent natural anti-inflammatories.
Infusion reactions are seen in patients receiving rituximab infusions. They may include hives, restlessness, swelling, difficulty breathing, fever, chills and changes in blood pressure. These are usually benign and respond to slowing down the infusion rate or other medications such as antihistamines, but can be severe. These are the most common reactions with the first infusion. As with other immunomodulatory therapies, infections can be increased in patients taking rituximab.
Arthritis In Hands Causes
Two x-rays of a patient showing acupuncture dysplasia a shallow hip. The patient started having hip pain when she was 20 years old a. This hip dysplasia was left untreated and 15 years later she had end-stage hip arthrosis b. Note the complete loss of articular cartilage space between the ball and the socket during this 15-year interval. Rheumatoid arthritis is a systemic disorder, that is, it affects the whole body and not just the hip joint.
Patient education: weight loss treatments beyond the basics Patient education: Hypercholesterolemia and lipids hyperlipidemia Beyond of Essence Patient Education: Bone Density Tests Beyond the Basics Patient Education: Calcium and Vitamin D for Bone Health Beyond the Basics Patient Education: Prevention and Osteoarthritis Treatment Beyond the Basics Patient Education: Non-Steroidal Anti-Inflammatory Drugs NSAIDs Beyond the Basics Patient Education: Total Hip Replacement arthroplasty
The researchers also found a decrease in BMI. acid consumption and moderate consumption of alcohol has a positive effect. In addition, getting enough vitamin D also helps to reduce inflammation, strengthen bone cartilage, and minimize the pain and risk of disability in sufferers, according to another 2004 study published. In Arthritis u0026 Rheumatism. According to the NHS, it’s unclear why the immune system attacks cells that line your joints by mistake, which triggers rheumatoid arthritis, but people at high risk are women, smokers and people with a history of family.
These effects have not been observed with the intravenous administration of free siRNA, which the researchers postulate is due to the inability of the uncomplexed material to enter the cell and to block the target mRNA. While the complex was effective at targeting only the area of interest, it has no side effects elsewhere. This is especially evident in the immune response, which was robust enough despite the treatment regimen, showing that this treatment has the potential to target only the elements of inflammation who have gone wrong in this arthritis model while sparing the immune system to respond to infections as required.
RA begins with inflammation, fatigue, joint pain and / or stiffness. As this condition worsens over time, you will experience flu-like symptoms and muscle aches. On the other hand, osteoarthritis is a “wear and tear” condition. Osteoarthritis is much more common with age and now manageable with cell therapy for osteoarthritis. Osteoarthritis begins with stiffness and joint pain and can be treated with stem cell therapy for osteoarthritis.
For some people, the injections of this thick liquid can help reduce the pain for a year or more. And clinical studies show that the therapy is as effective at relieving pain as non-steroidal anti-inflammatory drugs NSAIDs such as aspirin and ibuprofen. But these injections do not work for everyone, need to be administered relatively frequently and costly. For this reason, most doctors consider injections also called “fluid fluid” only as a backup plan if the other remedies do not work.
Programs on topics such as self-management skills, social support, biofeedback and psychotherapy are offered by the Arthritis Foundation in the United States and similar organizations around the world. . These services are also offered by many hospitals and clinics. It has been shown that these programs reduce pain, depression and disability in people with arthritis and enable them to control their disease. Rest – Fatigue is a common symptom of rheumatoid arthritis.Remedies For Arthritis Toes

domain: biology


Trump and Pence cling dueling rallies for Perdue and Kemp on eve of Georgia’s sour GOP gubernatorial number one
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COBB COUNTY, GA – Neither former President Donald Trump nor former Vice President Mike Pence are at the poll in Georgia, however each had been front-and-center in a flamable Republican Party feud at the eve of the Peach State’s number one.
Pence, headlining a rally for Gov. Brian Kemp, steered the governor’s supporters at an airport hangar within the northwest suburbs of Atlanta to “ship a deafening message all throughout America that the Republican Party is the a part of the long run.”


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Hello, my name is Keri Baptiste.
I'm the Assistant Gaming Editor and I study Creative Writing at City University. I'm currently in the process of writing a novel and spend the rest of my free time looking at terrible cat pictures.
Want to chat: email@example.com
Film Review: Churchill
Churchill is an emotive journey into one of the greatest Britons during one of the hardest times in British history.
Theatre Review: Punts @ Theatre 503
Punts is an interestingly unique performance that speaks on family structures, disabilities, sex workers and the act of sex itself.
TV Review: American Gods (Season 1, Episode 7)
Love, Betrayal and a whole of history follow Mad Sweeney and Laura Moon in this episode of American Gods.
Film Review: Wonder Woman
Wonder Woman is the action-packed female superhero film to clear our skin and water our crops.
Founder of the National University Esports League speaks about competitive gaming and social experiences
Competitive gaming isn't Just about winning the game - it's about the people that play with you and the experiences you have together.
TV Review: American Gods (Season 1, Episode 5)
Episode 5 of American Gods builds on plot, past and present with the return of Shadow’s dead wife and the first meeting of the Big Bad.
Far Cry 5 artwork depicts an idyllic Redneck Last Supper
The upcoming instalment of Ubisoft's Far Cry franchise is already proving controversial.
Can Wonder Woman Save the DC Cinematic Universe?
After the last three DC films, there is a lot of pressure on the super-shoulders of Wonder Woman - can she handle it as well as we all hope?
What I Played This Week – Prey
Prey is the newest sci-fi adventure from Arkane Studios and I've been loving every minute of it.
TV Review: American Gods (Season 1, Episode 3)
American Gods is proving to be a unique story about gods, myths and faith.
How Fast & Furious helps me cope with my mental health
Don't laugh at my coping mechanism.
Theatre Review: Identity Crisis @ Ovalhouse
Phina Orchue tells a wonderfully honest story of her life and her own struggling sense of identity.
TV Review: American Gods (Season 1, Episode 2)
Everything is kicked up a notch this week while the strange moments of incoherence are kicked to the wind.
Theatre Review: Paper Hearts @ Upstairs at the Gatehouse
Paper Hearts is a sweet romp through the love of books and a love that stems from that.
Sunday Book Review: How To Make A Wish by Ashley Herring Blake
With all the positive reviews, there was a high expectation for this novel – and it met every one.
What I Played This Week – Spyro: Gateway to Glimmer
This week we delved back into our nostalgic platforming past.


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Egypt saw a decline in its tourism industry after the February 2011 revolt that overthrew President Hosni Mubarak. (In BT's "To Go or Not to Go 2013," we gave Egypt a cautious "go.") But 2012 brought good news—11.5 million visitors came to the history- and art-rich nation, up 17 percent from the previous year. (In 2010, the last calendar year preceding the revolt, 14.7 million tourists paid Egypt a visit.) The resurgence was led by Western Europeans, followed by travelers from Eastern Europe and the Middle East. Thinking of joining the crowds? Here are some Egyptian must-sees:
Egyptian Museum. Located in Cairo, this world-class museum holds King Tut's chariots, iconic gold mask, and countless other masterpieces of Egypt's millennia-long history.
Giza. This pyramid 16 miles from Cairo includes the Great Pyramid (admission to its burial chamber is limited to 300 visitors per day in high season, September through March) and the Great Sphinx.
Nile River Cruise. Leave from Luxor and drink in views of temples, tombs, and ancient ruins along one of the world's most historic rivers.
Sharm El Sheikh. This Red Sea resort area is in the foothills of Mount Sinai and includes the powdery white sands of White Knight Beach.
Saqqara. This necropolis 14 miles south of Cairo offers 11 pyramids (including the famous Step Pyramid) and the Imhotep Museum. Mummies, sarcophagi, and significant tombs continue to be discovered at this archeological site.
Dahshur. Less than 30 miles south of Cairo, Dahshur is home to the Red Pyramid and the Bent Pyramid (its unusual angle creates the illusion that the structure is bending).

domain: geography


Arab Israeli Conflict
Middle East News
Hi Tech News
A sizeable chunk of the city's waste comes from disposable diapers used by large religious families.
Over the past decade, an increasing number of composters have been springing up in public parks, building courtyards, and private homes in Jerusalem.
The Jerusalem mayor blamed the fianance minister,and said that the municipality is ready to fire 2,150 employees.
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How to Change Location on Yik Yak for Enhanced Privacy and Interaction
Yik Yak has gained significant popularity in recent years as a unique social media platform that focuses on connecting people within a specific geographic area. However, many users find themselves wanting to explore content from other locations or connect with friends and family in different regions. In this comprehensive guide, we will explore different methods that allow you to change your location on Yik Yak and expand your social circle.
In this article:
Part 1. Understanding Yik Yak's Location Settings
Before we delve into the methods of changing your location on Yik Yak, it is essential to understand how the app's location settings work. Yik Yak utilizes the GPS sensors on your device to determine your precise location. By enabling location services and granting Yik Yak access to your location, the app can display posts from users within a 1.5-mile radius of your current location. When you create a post, Yik Yak adds a location stamp based on your device's GPS coordinates. It's important to note that Yik Yak does not store any location data, and your precise location is hidden from other users.
Part 2. Use the Peek Feature to Change Location on Yik Yak
Yik Yak offers a built-in feature called "Peek" that allows you to view posts from specific locations outside your 1.5-mile radius. While this feature does not directly change your location, it enables you to explore content from other areas. To use the Peek feature, you need to enable it in the settings menu. Once enabled, you can select a location on the map, and Yik Yak will display recent posts and threads from that area. While you can view posts from other locations using Peek, keep in mind that you won't be able to interact with them unless you change your location.
Part 3. Use GPS Spoofing Apps to Change Location on Yik Yak
If you want to change your location on Yik Yak more effectively, you can utilize GPS spoofing apps. These apps manipulate the GPS signals on your device, tricking Yik Yak into believing that you are in a different location.
One popular option for iOS users is the iRocket LocSpoof GPS spoofing app. This app allows you to change your iPhone's GPS location to any place in the world with just a single click. By installing LocSpoof on your computer and connecting your iPhone, you can easily change your location and explore posts from different areas on Yik Yak.
Highlights of LocSpoof:
- Seamlessly teleport your GPS location to any place in the world.
- Take complete control of your GPS location with 360-degree movement.
- Compatible with all location-based apps, including Facebook, Pokémon GO, Snapchat, and Find My.
- Compatible with both iOS and Android devices. (Including iPod/iPad)
- Enjoy a free trial accessible to all users.
100861 Users Downloaded
To change geolocation on your iPhone or iPad using LocSpoof, follow these steps:
- Connect your iPhone or iPad to your PC. Launch LocSpoof and click on the "Start" button.
- In the upper right corner, select "Teleport Mode" or use the multi-spot mode to simulate a route. Type the destination in the search bar and simply click the "Move" button to teleport to the new virtual location.
- Note: Launch the Maps app on your phone to verify your current location. Once confirmed, you can use this new location across all of your applications.
Change Yik Yak Location on Android
Changing geolocation on Android devices is relatively simple, especially if you're using Android 6.0 or newer. One popular app that doesn't require rooting your phone is LocSpoof - Fake GPS App. This app allows you to easily fake your Android phone's location.
To change geolocation on your Android device using LocSpoof [Apk Version], follow these steps:
- Download and install iRocket LocSpoof [APK Version] on your Android device.
- Choose your desired location by typing or clicking on the map to select a location (e.g., from LA to New York).
- Now, your Android device will consider you are in the new location, including all the apps on your device.
Part 4. FAQs About Changing Location on Yik Yak
Q1: Can I change my home-based location on Yik Yak?
Yik Yak does not provide an option to change your home-based location once it is set. The app uses your device's GPS to determine your location, and this location is registered against your phone number. Therefore, if you want to change your location on Yik Yak, you will need to utilize the methods mentioned above.
Q2: Is changing my location on Yik Yak against the app's terms of service?
While changing your location on Yik Yak using GPS spoofing apps or the Peek feature is not explicitly mentioned in the app's terms of service, it is essential to use Yik Yak responsibly and consider any potential risks. It's always a good idea to familiarize yourself with the app's guidelines and use it in accordance with its intended purpose.
Q3: Can changing my location on Yik Yak enhance my social circle?
Changing your location on Yik Yak can indeed expand your social circle. By exploring content from different areas, you can connect with individuals outside your immediate vicinity and engage in discussions with a broader range of users. This can lead to new friendships, diverse perspectives, and a more enriching Yik Yak experience.
Yik Yak provides a unique social media experience by connecting users within a specific geographic area. However, if you want to explore content from other locations or connect with individuals outside your immediate vicinity, it is possible to change your location on Yik Yak.
By utilizing the Peek feature or GPS spoofing apps, you can expand your social circle, engage in discussions from different areas, and make the most out of this exciting platform. Remember to use Yik Yak responsibly and adhere to the app's guidelines to ensure a secure and satisfying experience.


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LEADERS IN HEALTHCARE STAFFING SOLUTIONS
No one understands your recruitment needs better than us!
Of Market Leadership
Continents Served Proudly
With a legacy of 20 years, we have established ourselves as a trusted and reputed recruitment source among hospitals and job seekers.
We continue to push ourselves to strengthen the healthcare markets across the globe.
Being in the healthcare industry for more than 20 years now, we have an in-depth understanding of the challenges of this niche.
Varied Pool of Talent
Complete Employee Background Check
Expert Employee-Employer Matchmaking
Diverse Workforce and Trained Personnel
Flexi, Leasing & Permanent Recruitment Solutions
Extensive Training Programs
Immigration and Relocation Services
Salary Negotiation Assistance
Placements in the Top Hospitals and Institutions Across the World
We at IFANglobal are dedicated to providing the best of services to the healthcare sector. Keeping with this motive, we have crafted certain initiatives to facilitate improved recruitment solutions to both healthcare institutions and professionals.
IFANglobal has initiated a unique program ‘Get Me Wings’ to train the nurses for better job performance that also benefits their employers.
We also encourage hospitals and medical institutions to enroll their nurses in our noble endeavor with a view to building a stronger and skillful workforce.
IFANglobal introduces ‘JOBIZO’ app to fill the current healthcare recruitment gaps.
It is a unique matchmaking platform for hospitals, healthcare institutions and verified healthcare professionals like doctors, nurses and allied health to find each other as per their requirements without spending a lot of time and effort.
Our close associations with the top healthcare providers of the world make us the first ones to know about the upcoming job openings.
Register with us to know about the latest jobs in the healthcare sector on a regular basis.

domain: medical


KHOU – Fight over HOA power heads to Austin
The debate over how much power should be given to neighborhood homeowners associations is heating up again at the Texas state capitol.
On Tuesday, Houston-area groups, both for and against HOA reform, traveled to Austin to give lawmakers an earful.
It’s part of a national push to regulate HOAs, which critics say have way too much power.
To read the entire article, click here.


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Gum swelling, also known as gingival swelling or gum inflammation, is a common dental problem that affects many individuals worldwide. It is characterized by the enlargement or puffiness of the gum tissues surrounding the teeth. This condition can be caused by various factors, including poor oral hygiene, gum disease, hormonal changes, certain medications, and systemic health conditions. In this article, we will explore the causes, symptoms, and treatment options for gum swelling.
One of the primary causes of gum swelling is poor oral hygiene. When individuals fail to maintain proper dental care, plaque and bacteria can accumulate along the gumline, leading to inflammation and swelling. This condition, known as gingivitis, is the earliest stage of gum disease. If left untreated, gingivitis can progress to periodontitis, a more severe form of gum disease that can cause irreversible damage to the gums and supporting structures of the teeth.
Hormonal changes can also contribute to gum swelling, particularly in women. During pregnancy, hormonal fluctuations can increase blood flow to the gums, making them more susceptible to inflammation and swelling. This condition, known as pregnancy gingivitis, typically resolves after childbirth. Similarly, hormonal changes during puberty and menopause can also lead to gum swelling in some individuals.
Certain medications can have side effects that include gum swelling. For example, some anticonvulsant medications, calcium channel blockers, and immunosuppressants have been associated with gingival enlargement. If you are taking any medications and notice gum swelling, it is essential to consult with your healthcare provider to determine if the medication is the cause and discuss potential alternatives.
Systemic health conditions, such as diabetes and leukemia, can also contribute to gum swelling. Individuals with diabetes are more prone to gum disease due to impaired blood sugar control, which can weaken the immune system and make the gums more susceptible to infection. Leukemia, a type of blood cancer, can cause gum swelling as a result of abnormal white blood cell production.
The symptoms of gum swelling may vary depending on the underlying cause. Common signs include redness, tenderness, and puffiness of the gums. Some individuals may also experience bleeding gums, bad breath, receding gums, and loose teeth. If you notice any of these symptoms, it is crucial to seek dental care promptly to prevent further complications.
Treatment for gum swelling depends on the underlying cause and severity of the condition. In cases of mild gingivitis, improving oral hygiene practices, such as regular brushing and flossing, can help reduce inflammation and swelling. Your dentist may also recommend professional dental cleanings to remove plaque and tartar buildup.
For more severe cases of gum disease, additional treatments may be necessary. These can include scaling and root planing, a deep cleaning procedure that removes plaque and tartar from below the gumline. In some cases, antibiotics or antimicrobial mouth rinses may be prescribed to control infection and reduce inflammation.
If gum swelling is caused by hormonal changes, such as during pregnancy, no specific treatment may be required, as the condition typically resolves on its own after childbirth. However, maintaining good oral hygiene practices is still essential to prevent further complications.
In cases where gum swelling is caused by medication side effects or systemic health conditions, it is crucial to consult with your healthcare provider. They may adjust your medication dosage or recommend alternative medications to alleviate the symptoms. Managing the underlying health condition is also essential in controlling gum swelling.
In conclusion, gum swelling is a common dental problem that can be caused by various factors. Maintaining good oral hygiene practices, seeking regular dental care, and addressing any underlying health conditions are crucial in preventing and treating gum swelling. If you notice any symptoms of gum swelling, it is important to seek dental care promptly to prevent further complications and maintain optimal oral health.


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Last Nights Vice
|Last Night's Vice|
|Also known as||LNV, Last Night's Vice|
|Origin||St. Louis, Missouri, USA|
|Genres||Pop rock, alternative rock, dance-rock|
|Associated acts||Blinded Black
Last Night's Vice is a five-piece pop rock band from St. Louis, Missouri. After forming in 2006, the group self-released their debut EP called The Power Cosmic EP. Locally, some of their milestones would include playing at both Pointfest 27 and Pointfest 28 as well as the 2011 Fair Saint Louis. Nationally, Last Night's Vice has played at a number of iconic venues from The Cubby Bear in Chicago, Illinois and The Viper Room in Los Angeles, CA.
Last Night's Vice is known for their do-it-yourself mentality, taking charge of their own recordings, websites, videos, promotions and show-bookings. Their most recent music video for "Dance While You Still Have Time", filmed and edited by Jordan Phoenix(Guitarist) and Dave Moore, showcases their guerrilla promotional efforts.
Last Night's Vice is currently touring and promoting the release of their full-length album titled Perfect Little Noise.
Last Night's Vice is a culmination of two defunct St. Louis bands. Joe and Chris were original members of the band Blame Gary, while Andrew and Jordan had joined later. Blame Gary disbanded after a traveling back from a tough show in Topeka, KS.
Brandon was then the guitarist for the band Duke 45 and singer for Richboy Falling. Andrew had recorded demos for Brandon and recruited him for Last Night's Vice.
The Power Cosmic EP (2008)
The Power Cosmic EP was Last Night's Vice's first release. It was a 6-song EP with 2 additional songs that were available for download only from sites such as iTunes and Amazon. The album name and title track were inspired by the Silver Surfer comic book character.
Perfect Little Noise (2010)
The guys released their first full-length album produced by Andrew Ghiassi(Drummer) in summer 2010 at their concert sponsored by 105.7 the Point. They wrapped on their first music video spring 2010, filmed and edited by Anthony Meadows and Scott Hutcherson, for their single Lock and Key. They received mostly positive reviews from multiple music publications.
The End Is Near (2014)
This album was the first album released after Last Nights Vice separated with Joe, Blake and Jordan. It was released digital only in 2014 and was accompanied with a few one of shows since its release.
Last Night's Vice is considered to be a Pop-Rock band with a dance sound. They can borrow heavily from funk and metal as well and their songs are usually fast and energetic.
|Date of US Release||Title||Label|
|September 16, 2008||The Power Cosmic EP||Self-Released|
|August 31, 2010||Perfect Little Noise||Self-Released|
- "Sons of the Lawless at The Viper Room". songkick. September 9, 2010. Retrieved 11 July 2011.
- "REVIEW: Last Night's Vice "Dance While You Still Have Time" Music Video". InsideStl. June 17, 2011. Retrieved 11 July 2011.
- "A History of Last Night's Vice". lastnightsvice.com. Retrieved 11 July 2011.
- "The origin of the song and EP The Power Cosmic". lastnightsvice.com. Retrieved 11 July 2011.
- "Album Review: Last Night's Vice Perfect Little Noise". Live Music Guide. August 28, 2010. Retrieved 11 July 2011.
- "Last Night's Vice - 07.19.10". Absolute Punk. July 19, 2010. Retrieved 11 July 2011.


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Monday, November 23, 2009
Sarah and Christian's sunset wedding was in the beautiful little chapel in The Bluffs right here in St. Francisville, LA, on a beautiful cool fall evening. What a gorgeous couple! The one picture of Sarah and Christian standing just outside the doors of the church is a replica of one taken of Sarah's grandparents at their wedding, at Sarah's request.
As you can see, Christian and his friends are in the National Guard and active duty, and the three guys in uniform (including) will all be overseas in Iraq and Afghanistan by this time next year. Since both my brother-in-law and several close friends serve our country in the Louisiana national guard, I have a great respect for the men and women in the military, and therefore offer discounted photography services to them. Christian and Sarah were able to take advantage of that, and I hope that their wedding pictures will be what reminds them of each other after Christian deploys in January.
Thanks so much to my 2nd photographer and lighting assistant, Rachel, for all of her excellent help at the wedding!


Surprise Vote in U.S. House Today on Bill to Legitimize Human Cloning
Contact: Susan Armacost, Legislative Director, Wisconsin Right to Life, 414-778-5780
WASHINGTON, June 6 /Christian Newswire/ -- Wisconsin Right to Life learned late yesterday that a bill to foster the creation of cloned human embryos, for the purpose of using them in research that will kill them, will be on the floor of the U. S. House of Representatives today, Wednesday, June 6. The legislation, HR 2560, is sponsored by Rep. Diana DeGette (D-Co.).
"This is a blatant move on the part of the House Democratic leadership to ram the DeGette bill through the U.S. House," said Susan Armacost, Legislative Director of Wisconsin Right to Life. "This bill is being falsely labeled as a "ban" on human cloning but it is nothing of the sort! It is a bill to legitimize the use of cloning in order to create any number of human embryos for use in research that will kill them. Under this bill, it would be unlawful to attempt to allow such a human clone to live by implanting him or her in a womb."
The cloning vote will occur the day before the House is scheduled to take up S. 5, a bill to mandate federal funding of the kind of research that requires the killing of human embryos. The embryos utilized under S. 5 would be created by in vitro fertilization, not cloning. Wisconsin Right to Life strongly opposes S. 5.
To read the letter sent to U. S. House members by the National Right to Life Committee in opposition to the DeGette bill and for information on S. 5, go to www.nrlc.org


Have you checked out a very secretive cafe at 48 ¾ Niven Road?
Warm your belly with these new restaurants and cafes offering a wide range of food selections from Japanese-French cuisine to Spanish tapas-style bar. But if you’re looking for a more environment-friendly spot to relax and drink the day away, check out Paprika & Cumin and see what they have to offer.
While we can’t track them all, here are seven recently opened food hubs to satisfy your cravings.
Do you know any hot new restaurant that just opened or is coming up soon? Let us know by sending information to firstname.lastname@example.org.
Do you know more about this story? Contact us anonymously through this link.