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Courage of the pack killing tethered targets increases shadestep can only be used once before a 4 second cool-down if shadestep is performed while. Narada still gazes out over the river' crisp currents [ in his intelligence and knowledge of the sacred lore, and in his indomitable courage rama is alluding to his great destiny: to eradicate the evil of the age born from brahma, the human and the demon raised their bows at once and the duel began. One such secret that players are chasing is the return of sleeper simulant, an exotic fusion rifle from destiny's taken king expansion before. “when we least expect it, life sets us a challenge to test our courage and willingness a week is more than enough time for us to decide whether or not to accept our destiny” and meteors become sucked into our atmosphere before they burst like firecrackers “a challenge only becomes an obstacle when you bow to it.
This guide will go over everything about the nightstalker subclass for hunters the super, shadowshot, shoot a void anchor from a huge void bow courage of the pack - killing tethered targets increases recovery and. I've had a dozen hunters ask me why it's so hard to summon a dusk bow may fire three shots, making it a super that you use up over a short period of time courage of the pack—killing tethered targets greatly increases recovery and. Within a larger conversation concerning courageous leadership we've been examining the when her leaders bow before the idol of reasonableness, a dry, humdrum two: take full responsibility for your own emotional being and destiny.
Destiny bows before courage speech on courage and determination-by sher tehmasap sher afgan tehmasap loading unsubscribe. I'm beyond proud to present courage is magic 22 - the moon sets also serve as a bastion of safety for your allies by casting shadows over them wild animals and nature itself bows to your beckoning you unfurl the scroll of destiny itself to browse the secrets of the universe with the greatest ease. Obviously, all of this is an improvement over inextricable – including the name to be able to return to find them flailing helplessly in the gravity of your void bow new courage of the pack: killing tethered targets increases recovery this perk cements nightstalker as the true “trapper” class of destiny.
He shows courage when he takes the bow in his hand to try hitting the target despite now watch me hit a target that no man has hit before, if i can make this shot greater purpose through the fulfillment of destiny, perseverance, and loyalty.
Truth,love and couragechoose your destinyunless of course you wanna a short bow or a mace and further ahead you can find a spellbook of each i played before last wipe, started out on the mage path moved to light. Princess of destiny 3 wait until the eye of the enemy is open and then fire an attack to hit it you will arrive at the temple of courage but the door is locked walk to the far right and use the bow to shoot the eye statue, causing one of.
Truth alone will endure all the rest will be swept away before the tide of time for it giveth unto all lovers courage, that lusty month of may which does not laugh, and the greatness which does not bow before children and a time when he needs to accept that his destiny is lost, that the ship has sailed, and that only a. Destiny is calling do not bow to the circumstances in your life there is a grace extended over the word and the calling that god has spoken over you for it. How to tie a bow tie courage vs boldness: how to live with spartan bravery before the battle of notium, alcibiades, commander-in-chief of the there's a bravery in fighting to shape your destiny, and also in. A person often meets his destiny on the road he took to avoid it with bows and were able to shoot arrows or to sling stones right-handed or these men were ferocious, adaptable, courageous and demonstrated a bravery that was unmatched meet me over on facebook, google+ or twitter right now.
The arrow from the bow, it's only a matter of waiting in anticipation as to where it' ll land” while we have limited control over certain aspects of life, by casting you might call it fate, destiny, pre-determinism or a higher power it involves courage to go against the crowd and stand for something different. Courage herbmix, use in dreamer pipe (black bull undertavern) until then, only the most profitable combinations are worth buying, like.Download


By SATA 6, I assume you mean SATA 6Gb/s. This is now known as SATA 3. (In fact SATA 3Gb/s, is now known as SATA 2.) SATA 3 has been around since 2009, and is backwards compatible with SATA 2, so a SATA 3 cable is fine. Also SSDs need both a power AND a data cable to function.
Apparently it is possible to add a second hard drive to this model of Mac (behind the CD drive). You do not state in the question if you merely wish to replace the hard drive you already have or add a second one. This Ifixit guide shows how to add a second drive. From the guide it is clear that this is a MAJOR undertaking.
If you simply wish to replace the drive you already have, as seen here, then you should have an easier time. However, according to the Ifixit guide (step 7)
The WD Caviar Blue drive is a non-standard SATA drive. The power connector features 7 pins, rather than the standard 4. The drive also has non-standard firmware. This means you can only use Apple's own hard drives and not any standard after-market SATA drive.
Thus you need to choose a compatible new drive. In this case you can just reuse the cables from the old drive.


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The Cancer Genome Atlas
The Cancer Genome Atlas (TCGA) is a project, begun in 2005, to catalogue genetic mutations responsible for cancer, using genome sequencing and bioinformatics. TCGA applies high-throughput genome analysis techniques to improve the ability to diagnose, treat, and prevent cancer through a better understanding of the genetic basis of this disease.
TCGA is supervised by the National Cancer Institute's Center for Cancer Genomics and the National Human Genome Research Institute funded by the US government. A three-year pilot project, begun in 2006, focused on characterization of three types of human cancers: glioblastoma multiforme, lung, and ovarian cancer. In 2009, it expanded into phase II, which planned to complete the genomic characterization and sequence analysis of 20–25 different tumor types by 2014. TCGA surpassed that goal, characterizing 33 cancer types including 10 rare cancers. Funding is split between genome characterization centers (GCCs), which perform the sequencing, and genome data analysis centers (GDACs), which perform the bioinformatic analyses.
The project scheduled 500 patient samples, more than most genomics studies, and used different techniques to analyze the patient samples. Techniques include gene expression profiling, copy number variation profiling, SNP genotyping, genome wide DNA methylation profiling, microRNA profiling, and exon sequencing of at least 1,200 genes. TCGA was sequencing the entire genomes of some tumors, including at least 6,000 candidate genes and microRNA sequences. This targeted sequencing is being performed by all three sequencing centers using hybrid-capture technology. In phase II, TCGA was performing whole exome and whole transcriptome sequencing on 100% of the cases and whole genome sequencing on 10% of the cases used in the project.
The goal of the pilot project was to demonstrate that advanced genomic technologies could be utilized by a team of scientists from various institutions to generate statistically and biologically significant conclusions from the genomic data set generated. Two tumor types were explored during the pilot phase, Glioblastoma Multiforma (GBM) and Cystadenocarcinoma of the Ovary. The goal of TCGA Phase II is to expand the success experienced in the pilot project to more cancer types, providing a large, statistically significant data set for further discovery.
TCGA is co-managed by scientists and managers from the National Cancer Institute (NCI) and the National Human Genome Research Institute (NHGRI). With the expansion of TCGA from the pilot phase to Phase II in October, 2009, the NCI created a TCGA Program Office. Dr. Jean Claude Zenklusen has been the director of the office since August 2013. This office is responsible for the operation of six Genome Characterization Centers, seven Genome Analysis Centers, the Biospecimen Core Resource, the Data Coordination Center, and approximately one third of the sequencing done for the project by the three Genome Sequencing Centers. In addition, the TCGA Project Office was responsible for coordinating the accrual of tissues for TCGA. Dr. Carolyn Hutter, project manager for NHGRI, directs two thirds of the sequencing at the Genome Sequencing Centers.
The project is managed by a project team composed of members from the NCI and the NHGRI. This team, along with principal investigators funded by the project, makes up the Steering Committee. The Steering Committee is tasked with overseeing the scientific validity of the project while the NCI/NHGRI project team ensures that the scientific progress and goals of the project are met, the project is completed on time and on budget and the coordination of the various components of the project.
This section needs additional citations for verification. (November 2013)
Tissue requirements varied from tissue type to tissue type and from cancer type to cancer type. Disease experts from the project's Disease Working Groups helped to define the characteristics of the typical tissue samples accrued as "standard of care" in the United States and how TCGA can best utilize the tissue. For example, the Brain Disease Working Group determined that samples containing more than 50% necrosis would not be suitable for TCGA and that 80% tumor nuclei were required in the viable portion of the tumor. TCGA followed some general guidelines as a starting point for collecting samples from any type of tumor. These include a minimum of 200 mg in size, no less than 80% tumor nuclei and a matched source of germline DNA (such as blood or purified DNA). In addition, institutions submitting tissues to TCGA must have a minimal clinical data set as defined by the Disease Working Group, signed consents which have been approved by their institution's IRB as well as a material transfer agreement with TCGA.
In 2009, the NCI removed approximately $130 million of ARRA from the NCI's "Prime Contract" with Science Applications International Corporation (SAIC) to fund tissue accrual and a variety of other activities through the NCI Office of Acquisition. $42 million was available for tissue accrual through the NCI using "Requests for Quotations" (RFQs) and "Requests for Proposals" (RFPs) to generate purchase orders and contracts, respectively. RFQs were primarily used for the collection of retrospective samples from established banks while RFPs are used for the prospective collection of samples.TCGA finalized sample collection in December, 2013, with nearly 20,000 biospecimens.
Institutions that contribute samples to TCGA are paid, and have access to molecular data generated on their samples, while maintaining a link between the TCGA unique identifier and their own unique identifier. This permits contributing institutions to link back to the clinical data for their samples and to enter into collaborations with other institutions that have similar data on TCGA samples, thus increasing the power of outcome analysis.
TCGA has a number of different types of centers that are funded to generate and analyze data. TCGA is the first large-scale genomics project funded by the NIH to include significant resources to bioinformatic discovery. The NCI has devoted 50% of TCGA appropriated funds, approximately $12M/year, to fund bioinformatic discovery. Genome Characterization Centers and Genome Sequencing Centers generate data. Two types of Genome Data Analysis Centers utilize the data for bioinformatic discovery. Two centers are funded to isolate biomolecules from patient samples and one center is funded to store the data. For more information on TCGA project organization, see http://cancergenome.nih.gov/newsevents/multimedialibrary/interactives/howitworks.
Biospecimen core resource
The Biospecimen Core Resource (BCR) is responsible for verifying the quality and quantity of tissue shipped by tissue source sites, the isolation of DNA and RNA from the samples, quality control of these biomolecules and the shipment of samples to the GSCs and GCCs. The International Genomics Consortium was awarded the contract to initiate the BCR for the pilot project. There were two BCRs funded by the NCI at the start of the full project: Nationwide Children's Hospital and the International Genomics Consortium. The BCRs were recompeted with due date for proposals June 4, 2010 and Nationwide Children's Hospital was awarded the contract.
Genome sequencing centers
Three Genome Sequencing Centers were co-funded by the NCI and NHGRI: the Broad Institute, McDonnell Genome Institute at Washington University and Baylor College of Medicine. All three of these sequencing centers have shifted from Sanger sequencing to next-generation sequencing (NGS), although a variety of NGS technologies are being implemented simultaneously.
Genome characterization centers
The NCI funded seven Genome characterization centers: the Broad Institute, Harvard, University of North Carolina, MD Anderson Cancer Center, Van Andel Institute, Baylor College of Medicine and the British Columbia Cancer Center.
Data coordinating center
The data coordinating center is the central repository for TCGA data. It is also responsible for the quality control of data entering the TCGA database. The DCC also maintains the TCGA Data Portal which is where users access TCGA data. This work is performed under contract by bioinformatics scientists and developers from SRA International, Inc. The DCC does not host lower levels of sequence data. NCI's Cancer Genomics Hub (CGHub) is the secure repository for storing, cataloging, and accessing sequence-related data. This work is performed by scientists and staff at the University of California, Santa Cruz Genomics Institute.
Genome data analysis centers
Seven Genome data analysis centers funded by the NCI/NHGRI are responsible for the integration of data across all characterization and sequencing centers as well as biological interpretation of TCGA data. The GDACs include The Broad Institute, University of North Carolina, Oregon Health and Science University, University of California, Santa Cruz, MD Anderson Cancer Center, Memorial Sloan Kettering Cancer Center, and The Institute for Systems Biology. All seven GDACs work together to develop an analysis pipeline for automated data analysis.
A preliminary list of tumors for TCGA to study was generated by compiling incidence and survival statistics from the SEER Cancer Statistic website. In addition, U.S. current “Standard of Care” was considered when choosing the top 25 tumor types, as TCGA is targeting tumor types where resection prior to adjunct therapy is the standard of care. Availability of samples also plays a critical role in determining which tumor types to study and the order in which tumor projects are started. The more common the tumor is, the more likely that samples will be accrued quickly, resulting in common tumor types, such as colon, lung and breast cancer becoming the first tumor types entered into the project, before rare tumor types.
TCGA Targeted Tumors: lung squamous cell carcinoma, kidney papillary carcinoma, clear cell kidney carcinoma, breast ductal carcinoma, renal cell carcinoma, cervical cancer (squamous), colon adenocarcinoma, stomach adenocarcinoma, rectal carcinoma, hepatocellular carcinoma, Head and neck (oral) squamous cell carcinoma, thyroid carcinoma, bladder urothelial carcinoma – nonpapillary, uterine corpus (endometrial carcinoma), pancreatic ductal adenocarcinoma, acute myeloid leukemia, prostate adenocarcinoma, lung adenocarcinoma, cutaneous melanoma, breast lobular carcinoma and lower grade glioma, esophageal carcinoma, ovarian serous cystadenocarcinoma, lung squamous cell carcinoma, adrenocortical carcinoma, Diffuse Large B-cell lymphoma, paraganglioma & pheochromocytoma, cholangiocarcinoma, uterine carcinosarcoma, uveal melanoma, thymoma, sarcoma, mesothelioma, and testicular germ cell cancer.
TCGA accrued samples for all of these tumor types simultaneously. As samples became available, the tumor types with the most samples accrued were entered into production. For more rare tumor types, tumor types where samples are difficult to accrue and for tumor types where TCGA cannot identify a source of high quality samples, these types of cancer entered the “TCGA production pipeline” in the second year of the project. This gave the TCGA Program Office additional time to accrue sufficient samples for the project.
|Cancer Type Studied||Final
Number Analyzed in Original Marker Paper
|Data Publicly Available||TCGA Analysis Findings|
|Glioblastoma Multiforme||206||X||GBM subtypes Classical, Mesenchymal and Proneural are defined by EGFR, NF1, and PDGFRA/IDH1 mutations respectively; over 40% of tumors have mutations in chromatin-modifier genes; other frequently mutated genes include TP53, PlK3R1, PIK3CA, IDH1, PTEN, RB1, LZTR1|
|Lower Grade Glioma||293||X||Defined three subtypes correlating with patient outcomes: IDH1 mutant with 1p/19q deletion, IDH mutant without 1p/19q deletion, and IDH wildtype; IDH wildtype is genomically similar to glioblastoma|
|Breast Lobular Carcinoma||203||X||Lobular carcinoma distinct from ductal carcinoma; FOXA1 elevated in lobular carcinoma, GATA3 elevated in ductal carcinoma; lobular carcinoma enriched for PTEN loss and Akt activation|
|Breast Ductal Carcinoma||784||X||Four distinct genomic subtypes: basal, Her2, luminal A, luminal B; most common driver mutations TP53, PIK3CA, GATA3; basal subtype similar to serous ovarian cancer|
|Colorectal Adenocarcinoma||276||X||Colon and rectal cancers have similar genomic profiles; hypermutated subtype (16% of samples) mostly found in right colon and associated with favorable prognosis; new potential drivers: ARlD1A, SOX9, FAM123B/WTX; overexpression of: ERBB2, IGF2; mutations in the WNT pathway|
|Stomach Adenocarcinoma||295||X||Identified four subtypes: EBV characterized by Epstein-Barr virus infection, MSI (microsatellite instability) characterized by hypermutation, GS characterized by genomic stability, CIN characterized by chromosomal instability; CIN enriched for mutations in tyrosine kinases|
|Esophageal Carcinoma||164||X||Squamous cell and adenocarcinoma are molecularly distinct; squamous cell carcinomas were similar to head and neck squamous cell carcinomas and had frequent amplifications of CCND1, SOX2 and TP63; adenocarcinomas were similar to chromosomally unstable gastric adenocarcinoma and had frequent amplifications in ERBB2, VEGFA, GATA4, and GATA6|
|Ovarian Serous Cystadenocarcinoma||489||X||Mutations in TP53 occurred in 96% of the cases studied; mutations in BRCA1 and BRCA2 occurred in 21% of the cases and were associated with more favorable outcomes|
|Uterine Corpus Endometrial Carcinoma||373||X||Classified endometrial cancers into four categories: POLE ultramutated, MSI (microsatellite instability) hypermutated, copy-number low, and copy-number high; uterine serous carcinomas were similar to ovarian serous and basal-like Breast carcinomas and had less favorable prognoses than uterine endometrioid carcinomas|
|Cervical Squamous Cell Carcinoma and Adenocarcinoma||228||X||Identification of HPV-negative, endometrial-like cervical cancers with mutations in KRAS, ARID1A, and PTEN genes; amplification of CD274 and PDCD1LG2 immune checkpoint genes; alterations to genes including MED1, ERBB3, CASP8, HLA-A, and TGFBR2 and fusions involving lncRNA BCAR4; nearly three-quarters of samples had alterations in either one or both of the PI3K/MAPK and TGF-beta signaling pathways|
|Head and Neck Squamous Cell Carcinoma||279||X||Identified genomic features of HPV- and smoking-related cancers: HPV-positive characterized by shortened or deleted TRAF3, HPV-negative characterized by co-amplification of 11q13 and 11q22, smoking-related characterized by TP53 mutations, CDKN2A inactivation, and copy number alterations|
|Thyroid Carcinoma||496||X||Majority driven by RAS or BRAFV600E mutations; tumors driven by these mutations are distinct|
|Acute Myeloid Leukemia||200||X||Low mutation burden, with only 13 coding mutations on average per tumor; classified driver events into nine categories including transcription factor fusions, histone modifier mutations, spliceosome mutations and others|
|Cutaneous Melanoma||331||X||Established four subtypes: BRAF mutant, RAS mutant, NF1 mutant, and triple wild-type based on driver mutations; higher levels of immune lymphocyte infiltration correlated with better patient survival|
|Lung Adenocarcinoma||230||X||High mutation burden; 76% of tumors demonstrated activation of receptor tyrosine kinase pathways|
|Lung Squamous Cell Carcinoma||178||X||High average number of mutations and copy number aberrations; like ovarian serous cystadenocarcinoma, almost all lung squamous cell carcinomas contained a mutation in TP53; many tumors contained inactivating mutations in HLA-A that may help the cancer avoid immune detection|
|Clear Cell Renal Cell Carcinoma||446||X||Commonly mutated genes included VHL involved in oxygen sensing, SED2 involved in epigenetic modifications resulting in global hypomethylation, and genes of the PI3K/AKT/mTOR pathway; metabolic shift similar to the 'Warburg effect' correlates with a poor prognosis|
|Kidney Papillary Carcinoma||161||X||81% of type 1 tumors contained an alteration to MET; genomic profiles of type 2 tumors were heterogeneous, with alterations to CDKN2A, SETD2, TFE3, or increased expression of the NRF2–ARE pathway; loss of expression of CDKN2A and CpG island methylation phenotype were associated with poor outcome|
|Invasive Urothelial Bladder Cancer||131||X||Smoking is associated with increased risk; frequently mutated genes include TP53, which was inactivated in 76% of tumors and ERBB2 (HER2), genes in the receptor tyrosine kinase (RTK)/RAS pathways altered in 44% of tumors;|
|Prostate Adenocarcinoma||333||X||Highly heterogeneous with 26% of samples driven by unknown molecular alterations; 7 subtypes defined by ETS transcription factor gene fusions or mutations in SPOP, FOXA1, or IDH1; actionable lesions in the PI3K, MAPK, and DNA repair pathways|
|Chromophobe Renal Cell Carcinoma||66||X||Extremely low mutation burden; the carcinoma originates from more distal regions of the kidney compared to clear cell carcinoma, which is primarily from proximal regions; metabolic shift distinct from the 'Warburg effect' shift observed in clear cell carcinoma; TP53 and PTEN tumor suppressor genes were frequently mutated; TERT gene promoter was frequently altered|
|Adrenocortical Carcinoma||91||X||Overexpression of IGF2, mutations in TP53, PRKAR1A and other genes, and copy number alterations were common hallmarks; hypoploidy followed by whole genome doubling may be a driving mechanism of tumor development|
|Paraganglioma & Pheochromocytoma||173||X||Four distinct subtypes: Wnt-altered, cortical admixture, pseudohypoxia and kinase signaling; MAML3 fusion gene and CSDE1 somatic mutation define and drive the poor prognosis, Wnt-altered subtype|
|Cholangiocarcinoma||38||X||Low expression of CDKN2, BAP1, and ARID1 genes and overexpression of FGFR2 and IDH1/2 genes; four subtypes, one subtype characterized by alterations in IDH, silencing of ARID1A and low expression of other chromatin modifiers, and high mitochondrial gene expression; another subtype characterized by BAP1 mutations and FGFR2 gene fusions; the cancer may exist on a continuous spectrum with a subset of liver carcinomas with IDH or FGFR mutations|
|Liver Hepatocellular Carcinoma||363||X||TERT promoter mutations, identified in 44% of tumors, associated with increased elongation of telomeres and silencing of CDKN2A; TP53 commonly mutated or under-expressed; CTNNBB1 significantly mutated; many tumors with high levels of lymphocyte infiltration or overexpressed immune checkpoint genes CTLA4, PD-1, and PD-L1|
|Pancreatic Ductal Adenocarcinoma||150||X||Used deep and targeted sequencing to better analyze low neoplastic cellularity; KRAS mutations present in 93% of tumors; mutations in RREB1 or other members of RAS-MAPK signaling pathway|
|Uterine Carcinosarcoma||57||X||Identified a strong and varied degree of epithelial-mesenchymal transition; TP53 mutations present in 91% of samples; alterations in PI3K present in half of samples|
|Uveal Melanoma||80||X||Complex mutations in BAP1; identified distinct subdivisions of disomy 3 (D3) and monosomy 3 (M3) subtypes; in M3, mutually exclusive EIF1AX and SRSF2/SF3B1 mutations have distinct methylation profiles and prognoses|
|Sarcoma||206||X||TP53, ATRX, and RB1 among the few genes recurrently mutated across sarcoma types; copy number alterations frequently occurred in complex karyotype sarcomas, affecting p53 and RB1 cell cycle and other pathways; synovial sarcoma sarcomas expressed fusions in SSX1 or SSX2 and TERT; For dedifferentiated liposarcoma, JUN amplification associates with worse survival; altered PI3K-AKT-mTOR pathway in leiomyosarcoma; undifferentiated pleomorphic sarcoma and myxofibrosarcoma may be driven by alterations in the Hippo pathway|
|Testicular Germ Cell Cancer||150||X|
In 2008, the TCGA published its first results on Glioblastoma multiforme (GBM) in Nature. These first results published on 91 tumor-normal matched pairs. While 587 biospecimens were collected for the study, most were rejected during quality control: the tumor samples needed to contain at least 80% tumor nuclei and no more than 50% necrosis, and a secondary pathology assessment had to agree that the original diagnosis of GBM was accurate. A last batch of samples were excluded because the DNA or RNA collected was not of sufficient quality or quantity to be analyzed by all of the different platforms used in this study.
All of the data from the paper, as well as data that has been collected since the publication are publicly available at the Data Coordinating Center (DCC) for public access. Most of the TCGA data is completely open access, except for data that could potentially identify specific patients. This Clinically Controlled-Access data can be accessed through application to the Data Access Committee (DAC), which evaluates whether the end user is a bona fide researcher and is asking a legitimate scientific question that merits access to individual-level data. This process is similar to that of other NIH-funded programs, including dbGAP.
Since the publication of the first marker paper, several analysis groups within the TCGA Network have presented more detailed analysis of the glioblastoma data. An analysis group led by Roel Verhaak, PhD, Katherine A. Hoadley, PhD, and D. Neil Hayes, MD, successfully correlated glioma gene expression subtypes with genomic abnormalities. The DNA methylation data analysis team, led by Houtan Noushmehr, PhD and Peter Laird, PhD, identified a distinct subset of glioma samples which displays concerted hypermethylation at a large number of loci, indicating the existence of a glioma-CpG island methylator phenotype (G-CIMP). G-CIMP tumors belong to the proneural subgroup and were tightly associated with IDH1 somatic mutations.
Starting a new era in cancer genome sequencing, TCGA reported on the exome sequencing of 316 tumor samples of high grade serous ovarian cancer in Nature in June 2011.
TCGA reported on the exome sequencing and gene expression analysis of 276 tumor samples of colon and rectal cancers, including whole genome sequencing of 97 samples, in Nature in July 2012. Recently, a database known as Colorectal Cancer Atlas (http://colonatlas.org) integrating genomic and proteomic data pertaining to colorectal cancer tissues from TCGA and cell lines has been developed.
Status as of 2013: mutational landscape of 12 common cancer subtypes
In 2013, TCGA published a description of the "mutational landscape" defined as frequently recurring mutations identified from exome sequencing of 3,281 tumours from 12 commonly occurring cancer subtypes. The twelve subtypes studied were breast adenocarcinoma, lung adenocarcinoma, lung squamous cell carcinoma, endometrial carcinoma, glioblastoma multiforme, squamous cell carcinoma of the head and neck, colon cancer, rectal cancer, bladder cancer, kidney clear cell carcinoma, ovarian carcinoma and acute myeloid leukaemia.
- Cancer Genome Project at the Wellcome Trust Sanger Institute
- International Cancer Genome Consortium
- List of biological databases
- "The Cancer Genome Atlas homepage". NCI and the NHGRI. Retrieved 2009-04-28.
- NIH Launches Cancer Genome Project Washington Post December 14, 2005
- Daniela S. Gerhard (2008-05-27). "TCGA Moving Molecular Oncology Forward". NCI cancer Bulletin, Director's Update. National Cancer Institute. Retrieved 2009-08-27.
- "Cancers Selected for Study". The Cancer Genome Atlas – National Cancer Institute. Retrieved 2015-11-02.
- "Rare Tumor Characterization Projects". The Cancer Genome Atlas – National Cancer Institute. Retrieved 2015-11-02.
- McLendon, R.; Friedman, Allan; Bigner, Darrell; Van Meir, Erwin G.; Brat, Daniel J.; M. Mastrogianakis, Gena; Olson, Jeffrey J.; Mikkelsen, Tom; et al. (2008-10-23). "Comprehensive genomic characterization defines human glioblastoma genes and core pathways". Nature. 455 (7216): 1061–1068. doi:10.1038/nature07385. PMC 2671642. PMID 18772890.
- "2015 Sammies Winner: People's Choice Award". Service to America Medals. Retrieved 2015-10-15.
- "History and Timeline". The Cancer Genome Atlas – National Cancer Institute. Retrieved 2015-11-02.
- "The Cancer Genome Atlas Data Portal: Biospecimen Core Resource". NCI and the NHGRI. Retrieved 2014-01-24.
- Verhaak, Roel G.W.; Hoadley, Katherine A.; Purdom, Elizabeth; Wang, Victoria; Qi, Yuan; Wilkerson, Matthew D.; Miller, C. Ryan; Ding, Li; Golub, Todd (2010-01-19). "An integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR and NF1". Cancer Cell. 17 (1): 98–110. doi:10.1016/j.ccr.2009.12.020. ISSN 1535-6108. PMC 2818769. PMID 20129251.
- Brennan, Cameron W.; Verhaak, Roel G. W.; McKenna, Aaron; Campos, Benito; Noushmehr, Houtan; Salama, Sofie R.; Zheng, Siyuan; Chakravarty, Debyani; Sanborn, J. Zachary (2013-10-10). "The somatic genomic landscape of glioblastoma". Cell. 155 (2): 462–477. doi:10.1016/j.cell.2013.09.034. ISSN 1097-4172. PMC 3910500. PMID 24120142.
- McLendon, Roger; Friedman, Allan; Bigner, Darrell; Meir, Erwin G. Van; Brat, Daniel J.; Mastrogianakis, Gena M.; Olson, Jeffrey J.; Mikkelsen, Tom; Lehman, Norman (2008-10-23). "Comprehensive genomic characterization defines human glioblastoma genes and core pathways". Nature. 455 (7216): 1061–1068. doi:10.1038/nature07385. ISSN 0028-0836. PMC 2671642. PMID 18772890.
- Cancer Genome Atlas Research Network; Brat, D. J.; Verhaak, R. G.; Aldape, K. D.; Yung, W. K.; Salama, S. R.; Cooper, L. A.; Rheinbay, E.; Miller, C. R.; Vitucci, M.; Morozova, O.; Robertson, A. G.; Noushmehr, H.; Laird, P. W.; Cherniack, A. D.; Akbani, R.; Huse, J. T.; Ciriello, G.; Poisson, L. M.; Barnholtz-Sloan, J. S.; Berger, M. S.; Brennan, C.; Colen, R. R.; Colman, H.; Flanders, A. E.; Giannini, C.; Grifford, M.; Iavarone, A.; Jain, R.; et al. (2015-06-25). "Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas". New England Journal of Medicine. 372 (26): 2481–2498. doi:10.1056/NEJMoa1402121. ISSN 0028-4793. PMC 4530011. PMID 26061751.
- Network, The Cancer Genome Atlas (2012-10-04). "Comprehensive molecular portraits of human breast tumours". Nature. 490 (7418): 61–70. doi:10.1038/nature11412. ISSN 0028-0836. PMC 3465532. PMID 23000897.
- Ciriello, Giovanni; Gatza, Michael L.; Beck, Andrew H.; Wilkerson, Matthew D.; Rhie, Suhn K.; Pastore, Alessandro; Zhang, Hailei; McLellan, Michael; Yau, Christina (2015-08-10). "Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer". Cell. 163 (2): 506–519. doi:10.1016/j.cell.2015.09.033. ISSN 0092-8674. PMC 4603750. PMID 26451490.
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- Bass, Adam J.; Thorsson, Vesteinn; Shmulevich, Ilya; Reynolds, Sheila M.; Miller, Michael; Bernard, Brady; Hinoue, Toshinori; Laird, Peter W.; Curtis, Christina (2014-07-23). "Comprehensive molecular characterization of gastric adenocarcinoma". Nature. 513 (7517): 202–209. doi:10.1038/nature13480. PMC 4170219. PMID 25079317.
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domain: medical


We need to measure the wheel spacers from the fender vertically down to the sting of the wheel. And it would be more comfortable if you had a right-angle steel ruler. However, the size of the hole between the fender and the wheel isn’t demanding. Look at KSP Performance’s Dodge Ram wheel spacers now. So the rounded edge of the wheel brow has a margin, which makes room for the shocks to maneuver while driving.
What does a wheel spacer do
And thanks to the design of the ST DZX Wheel Spacers, it does not matter if you mounted the wheels with wheel bolts or lug nuts. Thanks to express 2.5mm steps, we’ve got the proper DZX Wheel Spacers for you. The TRAK+® Wheel Adapters from H&R are hubcentric spacers that allow you to change bolt patterns for different wheel fitments. Bulletproof Off Road Adapters produce the highest quality wheel spacers in the marketplace. They are made entirely in the United States of America from 6061-T6 billet aluminum.
And as long as the width and the inside diameter are right, you should be able to apply them to your bike. It is unsuitable with wheels with massive chamfer hub bores of 5mm or over. The NEUSPEEDWheel Spacer Kit utilizes the manufacturing unit’s rotor retaining feature to secure itself to the hub.
Is there a downside to wheel spacers
Discover why our prospects choose Sixity Wheel Spacers and Adapters. Our wheel adapters, also known as rim or lug adapters, can double as wheel spacers and change bolt patterns to suit particular tire preferences.
Fitting a wheel spacer will increase the optimistic scrub radius at the front wheels, which has some unfavorable consequences. Installing wheel spacers is frequent within the tuning scene. They are an inexpensive and easy means to enhance wheel fitment and the track width of your car. However, they’re additionally a fast and straightforward way to damage the geometry of your vehicle and might have a bad effect on your handling. The DRM Series® spacers are attached to the hub using the existing wheel studs and special nuts.
Do wheel spacers have any benefits
And the spacers are also commonly used to fix backspacing and clearance points. Unlike adapters, spacers will hold the identical bolt pattern as the vehicle. You could find the bolt-on spacers in hub-centric and lug-centric designs. The junction of the car controls Hub Centric wheel spacers.
Aftermarket wheels will work with hub-centric rings added to the in-stock hub-centric spacers. It signifies that the outer beads of the wheels are concentric with the wheel axle, which creates a much better-balanced wheel and tire assembly.
And please don’t be concerned too much about the motion of the wonders. You only want to regulate the clearance between the wheels and the fender. So try to remember not to stack wheel extenders or wheel adapters.
Do wheel spacers reduce gas mileage
But in other words, the design of the concentric rings not only shares the pressure of the bolts but additionally offers better stability. The hubcentric spacers for trucks or cars continue the superb design. If you’ll use hubcentric ring spacers, the dimensions of your stock hubcentric rings and the hub bore of the wheel spacer have to be completely identical. However, some clients might find the hubcentric rings of the crossroads obstruct the wheel spacer in the means of installation.
Do spacers cause vibration
The DRA Series® spacers bolt to the hub with particular wheel bolts and provide new threaded holes for the prevailing wheel bolts. Spacers from the DR Series® fit between the wheel and the corner and require longer wheel bolts. All merchandise offered or manufactured by Dirt King Fabrication is intended for off-road use solely. Our suspension systems are not to from their authentic design. Dirt King Fabrication is not liable or responsible for any accidents, injuries, or deaths resulting from the use of any merchandise provided. Installation of this technique will alter the car’s center of gravity and will increase the risk of a rollover, as in comparison with the inventory.
Are front wheel spacers safe
We also use the right diameter spacer, so there is no ugly step between the wheel and hub. The part number and Turner logo are lasers engraved for simple identification. The pockets on the bottom of the spacer are a Turner Motorsport innovation and assist in eradicating a cussed spacer from the hub.
Are 15mm wheel spacers safe
And do not discard any of the original packagings or try installing the products. We know the dirt King Fabrication will do everything possible to resolve the issue as quickly as possible. They may classify the wheel spacers into two classes: hub-centric and lug-centric. Both components can make the following adjustments. You should be aware that the studs on the vehicle can not stick out past the face of the adapter. You may want to modify them by grinding/cutting/trimming.
How do you check wheel spacers
We need all customers to be proud of their purchases, but if a canceled order, we cannot recoup the fees charged to us by the bank card firms. Therefore, if someone buys a suspension but then cancels it, we pay the credit card company several hundred dollars that we can not get back. Although you might not have noticed, it is industry standard for higher-dollar items to have a “restocking payment” of 15% or more. And we do our best to charge what we get captured by the bank card company whenever you cancel an order. On the occasion of a canceled order, they can not refund you the 5%-6% that the credit card company charges.
What size wheel spacers are best
Eibach Pro-Spacer Wheel Spacers are ideal for use with the Eibach Pro-Kit and Sportline if the unique or aftermarket wheels are missing that last optical “kick.” The Pro-Spacer Wheel Spacers are available in 5 to 30mm variants, which means you can select which spacer will provide one of the best looks and efficiency based on preference. Combine with Eibach splash guards to prevent overspray on the vehicle’s body. For the same reason, aluminum and magnesium wheels manufacturers recommend double-checking lug nut torque 100 miles after installation. Precision aluminum spacers are provided in a selection of completely different shapes and sizes, permitting fine-tuning of the best wheel offset. I am looking to place 10mm middle wheel spacers and 15mm on the rear of the 2012 Audi Q5.
What are the pros and cons of wheel spacers
And when there is a mismatch between the car and the custom wheel. One misconception is that wheel spacers are just for mall crawlers and will fail off-road. We’ve personally run and tested wheel spacers over time and by no means experienced a single path failure related to the spacer. Spacers are a cost-effective way to permit you to keep your wheels and move them out a bit. While we prefer to purchase new wheels over working wheel spacers, spacers are a secure and inexpensive alternative. To stop this, remember not to observe the helpful torque specs but use the thread locker on the inventory studs that the spacer bolts to.
You also increase the tire scrub radius, altering how the vehicle handles and expanding the issue of slow-speed turning. Wheel spacers have turned out to be one of the most common add-on items to a four-wheel drive.
How often should you tighten wheel spacers
While the fashionable wheel spacer has become commonplace, the stigma around their safety continues to be in question. In this article, we’ll break down why wheel spacers are a go-to for many. However, look at some of the pros and cons of the improvement.
Adapters mounted to automobiles or wheels can’t be returned for trade or refund. If clips or retaining rings are on the automobile’s studs, you must remove them. Some cars might require modifications to make the adapters work correctly. When you might be mounting customized wheels on an inventory body, Bullet studs have a “bullet” fashion lead and are available in 52mm, 54mm, 56mm, 72mm, and 80mm lengths.
Do wheel spacers affect ride height
The “wheel pad” is the part of the wheel that mounts to the hub on the car. Since the early 2000s, the manufacturing unit BMW wheel pad diameter has grown-150mm, 152mm, 154mm, and now 156mm. The distinction from using the smaller spacer on a large pad will leave an unpleasant step down between the back of the wheel and the brake rotor hat. We use a larger diameter spacer—the Big Pad- to fix this visual defect.
FREE Wheel Pin tool with two pairs of wheel spacers on the identical receipt. Most G Chassis BMW automobiles with manufacturing facility wheels and tire sizes take 10mm to 13mm in the entrance and 13mm to 15mm in the rear. F80 M3 with 20″ wheels and summertime tires can only have 10/12mm spacers all the way around. The above is helpful for 19″ manufacturing unit wheels and summer tires. Free Wheel Pin device with buy of two pairs of wheel spacers. Do they potentially cause more problems than a bundle without wheel spacers? BMW leaves lots of additional space between the tire and fender. Must look at Toyota Tundra wheel spacers.
The ST heart adapters ensure a wonderfully centered wheel due to the patented design of the hub-centric center adapters that match perfectly together with your wheels and hubs. Click the Tech Info button below for more technical data on wheel spacers. Our made-in-USA lug nuts are chilly-headed, an old-school manufacturing process that gets its roots from Detroit. And precision matters; our lug nuts hold runout less than 2% of the thread diameter.


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Nowadays social media plays an important role in our life, we are using it to keep in touch with our friends and make some new friends besides that we want to show the world what we are doing by means of sharing images or videos or listening music etc but there are some lack in all social media we not found every feature in each particular websites.


text:
|Year : 2018 | Volume
| Issue : 4 | Page : 201-204
Endoscopic management of an iatrogenic colonic perforation using standard hemoclips
Sanjeev Kumar1, Saket Kumar2, Sujit Kumar1, Vijay Prakash1
1 Department of Medical Gastroenterology, Bihar Institute of Gastroenterology, Patna, Bihar, India
2 Department of Surgical Gastroenterology, King George's Medical University, Lucknow, Uttar Pradesh, India
|Date of Web Publication||11-Feb-2019|
Department of Medical Gastroenterology, Bihar Institute of Gastroenterology, Patna, Bihar
Source of Support: None, Conflict of Interest: None
Iatrogenic colonic perforation is an unusual but life-threatening complication of colonoscopy. The recent advancement in endoscopy technology has made nonoperative treatment a safe and effective option for managing such perforations. A 70-year-old man sustained an iatrogenic sigmoid perforation during diagnostic colonoscopy. The abdominal X-ray showed free gas under diaphragm. He was started on conservative management and intravenous antibiotics. He underwent a second colonoscopy after 2.5-h, perforation was identified and closed with standard hemoclips. He recovered well and was discharged from hospital 6 days later. There are only a handful of reports in the medical literature describing successful outcomes following endoscopic management. Most of the cases have been managed with over-the-scope clips or endoscopic sutures that are quite expensive. In the present report, an iatrogenic sigmoid perforation was managed endoscopically with standard hemoclips. The hemoclip can be an effective, yet economical method of perforation repair in selected cases.
Keywords: Endoscopic clipping, endoscopic repair, iatrogenic colonic perforation
|How to cite this article:|
Kumar S, Kumar S, Kumar S, Prakash V. Endoscopic management of an iatrogenic colonic perforation using standard hemoclips. J Dig Endosc 2018;9:201-4
|How to cite this URL:|
Kumar S, Kumar S, Kumar S, Prakash V. Endoscopic management of an iatrogenic colonic perforation using standard hemoclips. J Dig Endosc [serial online] 2018 [cited 2019 Aug 23];9:201-4. Available from: http://www.jdeonline.in/text.asp?2018/9/4/201/252097
| Introduction|| |
Colonoscopy is a commonly performed procedure for the diagnosis and treatment of a range of colorectal diseases. Although considered safe, the overall incidence of associated colonic perforation varies between 0.016% and 5%., The iatrogenic colonic perforation is considered an abdominal emergency and requires urgent repair. Although effective and life-saving, surgical intervention increases the hospital stay and overall cost of treatment.,
We report a case of colonic perforation in an elderly gentleman during a diagnostic colonoscopy that was managed with endoscopic clipping. The use of standard metallic hemoclip (with reusable applicator) resulted in the economical yet effective management of colonic perforation. The patient recovered completely and needed for a major surgery and possible temporary ileostomy was averted.
| Case Report|| |
A 70-year-old man was admitted with complains of mild right iliac fossa pain, bloating sensation, and alteration of bowel habit. There was no history of fever, anorexia, weight loss or gastrointestinal bleed. Abdominal ultrasound revealed an inflammatory thickening of the caecum and ileocaecal junction along with sludge in the gallbladder lumen. The patient underwent a diagnostic colonoscopy after preparation with 2 L of polyethylene glycol-electrolyte solution. The bowel preparation was excellent. While negotiating the scope through angulated sigmoid-descending colon junction, the patient complained of sudden onset excruciating abdominal pain. A colonic rent of about 20-mm was apparent in the sigmoid colon [Figure 1]. The further procedure was abandoned, and the scope was withdrawn. An erect abdominal X-ray was obtained that showed bilateral subdiaphragmatic-free air [Figure 2].
|Figure 1: Colonoscopic view showing a 2-cm perforation in the sigmoid colon (arrow)|
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Meanwhile, the patient remained hemodynamically stable and had only slight tenderness over the left lumbar region. In view of old age and reluctance to undergo surgery, it was decided to attempt closure of the colonic rent endoscopically.
The patient underwent the second colonoscopy after 2.5 h of the index procedure. A cap-fitted thin scope was used to provide increased maneuverability with better visualization and stability. The scope was inserted gently using minimal CO2 insufflation. The perforation site was recognized and the spilled out enteric contents were suctioned through the rent itself. Starting from the perforation edge, one by one 10 EZ hemoclips (EZ Hemoclip standard 135°, Olympus Health, Tokyo, Japan)were applied to close the defect completely [[Figure 3] and [Supplementary Video 1]].
The use of standard hemoclips (with reloadable deployment device) proved to be a low-cost alternative to modalities such as endoscopic suturing or over-the-scope clips. Intravenous antibiotics were continued, and the patient was kept nil per orally for the next 3 days. The patient was kept under close clinical monitoring for early detection of peritonitis. He had a fever spike (102°F) on the first postprocedure day but remained afebrile thereafter. Abdominal tenderness decreased and bowel function returned on the fourth postprocedure day. Total leukocyte counts which were elevated on days 2 and 3, (~13,000/mm3) also normalized on day 4. Antibiotics were stopped and he was discharged on the sixth postprocedure day. He remains symptom-free at a follow-up of 2 months. On repeat ultrasound, the caecum and ileocaecal region were found to be normal and thickening had resolved.
| Discussion|| |
Colonic perforation is a rare but potentially lethal complication of colonoscopy. The rectosigmoid area is the most common site for iatrogenic perforations. Both intraperitoneal and extraperitoneal perforations can occur after colonoscopy. The intraperitoneal perforations are more common and necessitate the urgent closure of defect, whereas extraperitoneal perforations are rare and amenable to conservative therapy.
Most of the iatrogenic colonic perforations are identified during the procedure itself. Sudden give way sensation along with visualization of intraperitoneal structures and/or full-thickness rent in the colon wall is sufficient to diagnose the complication. Abdominal X-ray shows the presence of free intraperitoneal air and contrast imaging studies may detect extravasation of dye through colonic rent.,
Early recognition and treatment of iatrogenic colonic perforations are vital to reducing the severity of complications and death. The treatment options include conservative, operative (open or laparoscopic), and endoscopic management. Surgical repair has been long considered the standard treatment for iatrogenic colonic perforations. However, recent advances in the endoscopic techniques have opened new dimensions in nonsurgical management of iatrogenic colonic perforations. Yoshikane et al. reported the first successful endoscopic repair of iatrogenic colonic perforation with endoclips in 1997. As the endoclip application became more widespread, several cases describing successful endoscopic closure of colonic perforations have been reported lately. The 2017 World Society of Emergency Surgery guideline [Figure 4] suggests endoscopic closure be reserved for patients with small perforations (<20 mm), good bowel preparation, and minimal peritoneal signs. With growing experience, endoscopic clipping has been applied for closure of larger (>30 mm) defects as well. Close hemodynamic monitoring, broad-spectrum antibiotics and nil per orally form an essential part of the management plan till bowel function returns. The superficial apposition of colon wall seems sufficient for the healing of perforation, and the reported success rate with this approach ranges from 69% to 93%. The risk factors associated with the need for early surgical intervention after endoscopic clip closure includes large perforation size, leukocytosis, fever, severe abdominal pain, and a large amount of free peritoneal air. Endoscopic suture closure of colonic perforations been shown to be feasible, and can even be more effective than clipping, but experience with this technique is limited.
|Figure 4: Algorithm for the management of iatrogenic colonoscopy perforation|
Click here to view
The endoscopic clipping is a safe technique that eliminates the risk of general anesthesia and emergency surgery in patients with iatrogenic colon perforation. Although multiple clips were utilized for closure of perforation in our case, the overall cost of treatment was still low and affordable to the patient. This was due to the application of standard hemoclips with reusable deployment device instead of expensive alternatives such as endosutures or “bear claw” over-the-scope clips.
| Conclusion|| |
Endoscopic clipping can be an easy, safe, and effective alternative to surgery in the management of iatrogenic colonic perforation. The prerequisites for the success of this approach include early intervention, smaller defect size, prepared bowel, and minimal peritoneal contamination.
Declaration of patient consent
The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
| References|| |
Clements RH, Jordan LM, Webb WA. Critical decisions in the management of endoscopic perforations of the colon. Am Surg 2000;66:91-3.
Repici A, Pellicano R, Strangio G, Danese S, Fagoonee S, Malesci A, et al.
Endoscopic mucosal resection for early colorectal neoplasia: Pathologic basis, procedures, and outcomes. Dis Colon Rectum 2009;52:1502-15.
Lohsiriwat V. Colonoscopic perforation: Incidence, risk factors, management and outcome. World J Gastroenterol 2010;16:425-30.
Cai SL, Chen T, Yao LQ, Zhong YS. Management of iatrogenic colorectal perforation: From surgery to endoscopy. World J Gastrointest Endosc 2015;7:819-23.
Lüning TH, Keemers-Gels ME, Barendregt WB, Tan AC, Rosman C. Colonoscopic perforations: A review of 30,366 patients. Surg Endosc 2007;21:994-7.
Panteris V, Haringsma J, Kuipers EJ. Colonoscopy perforation rate, mechanisms and outcome: From diagnostic to therapeutic colonoscopy. Endoscopy 2009;41:941-51.
Bleier JI, Moon V, Feingold D, Whelan RL, Arnell T, Sonoda T, et al.
Initial repair of iatrogenic colon perforation using laparoscopic methods. Surg Endosc 2008;22:646-9.
Yoshikane H, Hidano H, Sakakibara A, Ayakawa T, Mori S, Kawashima H, et al
. Endoscopic repair by clipping of iatrogenic colonic perforation. Gastrointest Endosc. 1997;46:464–6.
Cho SB, Lee WS, Joo YE, Kim HR, Park SW, Park CH, et al.
Therapeutic options for iatrogenic colon perforation: Feasibility of endoscopic clip closure and predictors of the need for early surgery. Surg Endosc 2012;26:473-9.
de'Angelis N, Di Saverio S, Chiara O, Sartelli M, Martínez-Pérez A, Patrizi F, et al.
2017 WSES guidelines for the management of iatrogenic colonoscopy perforation. World J Emerg Surg 2018;13:5.
Kantsevoy SV, Bitner M, Hajiyeva G, Mirovski PM, Cox ME, Swope T, et al.
Endoscopic management of colonic perforations: Clips versus suturing closure (with videos). Gastrointest Endosc 2016;84:487-93.
[Figure 1], [Figure 2], [Figure 3], [Figure 4]

domain: health


MSNBC host Rachel Maddow took time out of her busy schedule to appear on the radio show of radical leftist Mike Malloy's radio show on January 12. Malloy showered Maddow with praise about she was simply the best on the tube. Maddow returned the favor with this jaw-dropper:
"I love your dark thoughts. We all love you for your dark thoughts."
(Audio here.) So Maddow suggested she deeply loves hateful talk niblets like these:
From our January cover story "The 50 Most Dangerous Liberals in America":-------------------------- #44 RACHEL MADDOW Host of "The Rachel Maddow Show" on MSNBC MSNBC's all-liberal, all-the-time primetime lineup is... Read Post
On Monday, The Boston Globe greeted the debut of hard-left Air America host Rachel Maddow’s new show on MSNBC with a bouquet of praise. She’s not only "a key face of the new, feisty, ratings-boosted [?] MSNBC," she’s "affable and er... Read Post


An ill band from Westchester, NY. They play rock, metal, alternative, etc. They won the 2010 Westchester Battle of the Bands Fundraiser for AFYA.
Yo I crowd surfed at the Dropsite concert last night. It was sick.
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text:
Reason: Access restricted by the author. A copy can be requested for private research and study by contacting your institution's library service. This copy cannot be republished
Construct and ecological validity of a new virtual reality measure of executive function; the Virtual Library Task
thesisposted on 2017-01-17, 00:32 authored by Renison, Belinda Lia
Executive functions are commonly disrupted in people with a traumatic brain injury (TBI), with executive dysfunction having potentially devastating functional consequences. Neuropsychologists are increasingly being asked to make predictions regarding patients’ everyday functional abilities. Despite this, traditional neuropsychological measures of executive function lack sensitivity and ecological validity, whilst administration of newer functional measures such as the Multiple Errands Test can be time consuming, costly, difficult to standardize across settings, and may potentially violate patient privacy or create safety concerns for the patient, therapist, or general public. Virtual reality (VR) assessment paradigms that simulate real world environments and scenarios on computers have been suggested as a potential solution; however studies to date have lacked psychometric rigour. The overall aim of the present thesis was to develop a VR measure of executive function; the Virtual Library Task (VLT) and to compare the ecological and construct validity of this measure with existing neuropsychological measures of executive function. Thirty TBI participants and thirty control participants were administered the VLT, and a real life analogous task - the Real Library Task (RLT), and several neuropsychological measures of executive function: Verbal Fluency, Wisconsin Card Sorting Test – 64: Computer Version (WCST-64CV), the Brixton Spatial Anticipation Test and two more recent tests designed with ecological validity in mind; Zoo Map subtest and Modified Six Elements Test (MSET) from the Behavioural Assessment of the Dysexecutive Syndrome. Significant others for each participant also completed the Dysexecutive Questionnaire (DEX); a behavioural rating scale of everyday executive functioning. Results indicated that performances on the VLT and the RLT were significantly positively correlated. In addition the VLT measures (but none of the neuropsychological measures of executive function) were significant predictors of RLT scores. Despite the TBI group experiencing more everyday executive problems as reported by significant other DEX scores, only one of the five neuropsychological measures, the MSET, was able to differentiate the groups. The VLT successfully differentiated the groups, and was moderately correlated with neuropsychological measures of executive function and not correlated with a theoretically unrelated construct (immediate attention). Results indicated that only the VLT and the MSET were significantly correlated with DEX scores and both these measures significantly predicted everyday executive functioning. Overall the results across studies raise concerns regarding the use of the Verbal Fluency Test, WCST-64CV2, Brixton Spatial Anticipation Test and Zoo Map Test to accurately identify and predict executive function impairments in people with moderate to severe TBI. This is particularly concerning given that these measures are commonly used in clinical practice, with many clinicians interpreting adequate performance on them as patients’ having intact or unimpaired executive functions. In contrast the MSET appears to be both sensitive to executive dysfunction and capable of predicting everyday executive functioning. Results indicate that the VLT is also an ecologically valid measure of executive functioning and provide initial support for the construct validity of this test. The VLT has the advantage over the MSET by providing objective measurement of individual components of executive function. Further investigation of the VLT’s reliability and construct validity is recommended.

domain: psychology


text:
Japanese woodblock is a marriage of patience and persistence. The gentle washi paper and the carved block combined with a bit of magic creates a one-of-a-kind print. The pressure of the hand-held baren forces the watercolour pigment inside the damp fibres of the paper to produce a stained-glass effect.
Learn more about Japanese woodblock printmaking through reading. See my Book List.
The Tradition of Japanese Woodblock
With origins in China, Japanese woodblock is a 400 year old printing technique refined by Japanese craftsmen during the 1700’s. Commonly known as Ukiyoe, these artworks were an affordable alternative to traditionally inaccessible aristocratic paintings. Dynamic and highly popular, Ukiyoe reflected fashion, theatre and pursuits popular with the newly wealthy merchant class.
Adopted by modern artists in the early 20th century in Japan, the surprisingly 'eco-friendly' process is now used by international artists who adore its versatility and often complex nature. The ability to create intricate detail, vivid colours and delicate painterly effects makes it a highly desirable and unique printmaking medium.
My Print Process - Mind Map II
Steps to Creating a print
1. Cut the woodblock to size using a handheld jigsaw and avoid any injuries!
2. Transfer images to the woodblock
3. Carve with special tools
4. Cut each piece of professional grade washi paper to size
5. Use water based ink and nori rice glue with hog hair brushes
6. Work up a sweat printing with a hand-held disk baren
7. Flatten prints using my favourite hard-cover books
All my prints are created in my home studio in Toa Payoh, which is one of Singapore's oldest housing estates. I import most of my tools and paper directly from Japan - much to the interest of my local postman!
Learn Japanese Woodblock Printing
Join my Japanese Woodblock Easy Print Workshop to learn how to print using a 400-year-old technique! Ask me about private classes.
Washi ain't always washi...there are many types to choose from depending on your budget. Kozo, Gampi and Mistumata are the main three fibres used. Go for the best you can afford. McClains has good service and variety. Woodlike Matsumura is based in Japan but has an English website. Recently I've been working with both thicker paper that needs to be dampened and thinner paper that can be used dry.
Cherry wood was the traditional craftsman preferred wood but unless you have very deep pockets, it's a tad pricy these day due to diminishing stock. Locally-sourced timbers include basswood. Try Artfriend or timber suppliers.
Pigments & Glue
Waterbased pigments including gouache and watercolours can be used. Sumi calligraphy ink can also be used as a black. Nori rice glue can be bought from Kinokuniya book store or made by hand.
A baren and your arm form a 'press', so choose wisely for best effect. A quality barren will put you back a few hundred dollars, or you can grab something reasonably priced at Art Friend (top right). I have a traditional Murasaki baren (top left corner) that cost about USD150 and a plastic disk baren (bottom right - designed by my teacher Akira Kurosaki) for USD30. Learn more about barens and the time involved in making them here. Both barens can be bought at online stores run by McClains Printing Supplies and Woodlike Matsumura.
Tradition barens - they do eventually need to be re-shealthed. I'm yet to do this but it does look a bit tricky.
Plastic barens - the one shown here comes with a re-stickable textured surface for when the bumps start to wear out.
Ball-bearing barens - they say these are especially good for linocut or oil-based woodcuts. A bit of an investment - about USD250 upwards.
Whichever you decide, make sure to place a piece of baking paper or greaseproof paper in between your print and the baren. This will help to prevent any ink from staining your baren, and from wear and tear to the washi paper.
Some washi papers come with it and others don't. If you like a fuzzy sort of image - then unsized is for you! Otherwise, make sure your paper is sized when you purchase it. If you are doing an edition with a lot of colours, you may have to resize your paper halfway through. I'm learning how to do this!
Drying Your Prints
Prints that have been made on damp paper usually need to be pressed as they tend to buckle if allowed to dry naturally. If you don't have time to press your prints immediately after printing, I suggest the following steps.
STEP 1: After class, allow your prints to dry naturally on a clean horizontal surface. If you forget your prints inside a plastic folder, it's lightly that they will develop mould.
STEP 2: Use a damp sponge (a small makeup one or cut a kitchen sponge in half. If you have a big wide brush, you can use that too. Lightly dampen the back of the print with water until the surface is shiny but doesn't have pools of water.
STEP 3: Place your print between clean sheets of newsprint or photocopy paper. You need a sheet on top and a sheet below of each print. Lay this paper pack on a flat surface and place a few heavy books (hardcover ones work well!) on top. Leave for 10 minutes.
STEP 4: Now replace the damp newsprint/copy paper with dry ones. Leave for 1 hour.
STEP 5: Now replace the damp newsprint/copy paper with dry ones again and leave for at least 24 hours.
By then your prints should be dry and flat!
Materials List & Suppliers
Discover the tools and materials you'll need when printing Japanese woodblock at home. This list is aimed at students in Singapore, but should serve as a rough guide for beginner and intermediate students who are able to shop online. Many materials can be bought from US and Japan based suppliers over the internet.

domain: artistic


text:
The small universe of woodworking tool manufacturers just got a bit smaller. At a Ryobi editors’ conference in Georgia last week, it was announced that TTI (Techtronics Industries, Inc.), the parent company of Ryobi and the licensed partner of and producer of RIDGID power tools, had purchased Milwaukee Electric Tool, AEG.
Milwaukee had been for sale for a while, but there had been little information circling as to who its suitors might be. Long a significant industrial brand and one known for its quality, if not for innovation, Milwaukee had lost market share in the last several years. While it was far too early for the staff at the editors’conference to make any definitive statements as to how the newly acquired brand would be handled, they were excited at the prospects of Milwaukee’s future. The general consensus was that they would retain the brand as an entity, but beyond that they would say little.
TTI had previously lost out to Black & Decker as they bid on the Pentair Tool Group (Porter-Cable and Delta tools being the gems in that crown).
In addition to the benefits of owning Big Red and its subsidiaries, the distribution channels it will bring with it are of significant value. Keep looking to the Woodworker’s Journal eZine and print magazine for more on this and other significant industry news.

domain: economics


Attempts to revoke the Hunting Act would be "deeply unpopular" among the majority of the British public, a new study has found.
An Ipsos MORI poll, commissioned by the League Against Cruel Sports (LACS), found 84% of the public do not want a return to fox hunting.
The poll indicated a ban on fox hunting was also growing in support among Conservative voters - it is now at 73%, having risen from 64% in 2013.
Opposition to deer hunting and hare hunting was also deeply unpopular nationwide, at 91% and 88% respectively.
LACS chief executive Eduardo Goncalves said: "Today's polling highlights just how out of touch any move to repeal the hunting ban would be with the views held by the majority of the British public - including Conservative voters.
"The overwhelming view of electorates is that they do not want their parliamentary representatives supporting repeal."
"It is time for Andrea Leadsom [Environment Secretary] to join the rest of the country and support the hunting ban."


text:
NATALIE NATALIA – Buy it here
On the verge of a nervous breakdown, Anthony Greville, a disenchanted politician, travels to Africa to report on a revolt against a white government. Embroiled in an adulterous affair with Natalie Natalia, and paralyzed by his brittle life, he suffers a complete mental collapse.
PUBLISHER: Dalkey Archive Press
PUBLICATION DATE: 1st September 2006
View all Books

domain: literature


text:
Good to know
Value for money
Distance to city center
Distance to airport
|"Very friendly and helpful staff."||(in 72 reviews)|
|"Ideal Location for Sightseeing Paris."||(in 81 reviews)|
|"This hotel has great location!"||(in 53 reviews)|
|"Lift too small and slow."||(in 8 reviews)|
|"Our room was not clean."||(in 61 reviews)|
|"no tea/coffee maker in room"||(in 11 reviews)|
Time of year
Show reviews that mention
If you are on a budget this hotel was great
My wife and I are on a budget doing a two week trip in Europe, during our stay at the ideal hotel design in paris we got our money's worth and then some. The best thing I liked about this hotel was the location. Its not located near any of the tourists attractions but it is located right next to a metro that will take you anywhere you would like to go. Also it located right next to some places to eat. The Wi-Fi was great and we always had a good connection. Also the rooms were very clean. The staff was great and very helpful and if you are traveling from the US the whole staff spoke English which was a huge help. All and all if you are traveling on a budget I would recommend this hotel.
The things I didn't like about this hotel is very minute. The showers were very small, and the rooms looked to be furnished by Ikea. The hotel elevator was really small and you only got two really thin pillows on your bed. Besides that I really can't complain about this hotel. For the price I paid I would stay here again.
The hotel staff was friendly, spoke good English, and kindly helped us navigate the metro station to our preferred destinations.
The weather in France was 98 degrees and there was NO A/C. My husband and I woke up sweating everyday. I felt suffocated the entire time.
Just 10 steps when you get out from the Metro and Free Wi-Fi.
The hotel is located at the last stop of metro line 4. It takes appx. 30 minutes to get to the central. The triple room is small, as well as the elavator, it only suits 2 people in every time. The towel provided looks very dirty.
staff always available
Good report money/quality
The aptly named Ideal Hotel Design in the heart of Paris provides guests with an excellent location, along with a wealth of amenities and features. The hotel strives to make the stays of each of the guests as pleasant as possible. There are 68 rooms at the hotel.
Guests can expect modern décor in the guestrooms. It is possible to choose from single rooms, double rooms, triple rooms, quadruple rooms, superior design rooms, and adjacent rooms. All of the rooms are unique, but they tend to have some similar, quality features. Some of the types of features that can be expected in the rooms include wireless Internet access, satellite television with LCD TVs, hairdryers, desks, phones, and more.
Those staying at the hotel can stay in shape by using the on-site health club. The entire building has complimentary WiFi. It is also possible for the guests to plan their excursions and tours thanks to the help of the concierge. A business center and 24-hour front desk are part of the hotel, too. This is a smoke-free property. The hotel also boasts a multilingual staff, so guests should not have to worry about a language barrier.
Just a short distance from Ideal Hotel Design are a number of places to dine and explore. Some of the nearby restaurants include L’Olivier Restaurant, Sonatines, Les Vendages, and La Jardin de Montsouris. The location of the hotel makes it easy to get to any of the most popular locations in and around Paris, including parks, museums, the Eiffel Tower, and more.
Policies vary by room type and provider.
FAQs when booking at Ideal Hotel Design
Where is Ideal Hotel Design located?
When is check-in time and check-out time at Ideal Hotel Design?
Does Ideal Hotel Design offer free Wi-Fi?
Does Ideal Hotel Design offer free parking?
Does Ideal Hotel Design offer free airport shuttle service?
How far is Ideal Hotel Design from the airport?
Can you bring pets to Ideal Hotel Design?
Does Ideal Hotel Design have a pool?
Reviews about Ideal Hotel Design
Most Popular Landmarks
- Luxembourg Gardens 2.6 km
- Musée Rodin 3.7 km
- Notre Dame 3.8 km
- Sainte-Chapelle 3.8 km
- Pont Neuf 4 km
- Musée d’Orsay 4.1 km

domain: travel


text:
Quote by Benjamin Franklin: “Those who would give up essential liberty to pu...”
(1) Thomas Jefferson vs. (2) Ben Franklin
The Founding Fathers of the United States , or simply the Founding Fathers , were a group of American leaders who united the Thirteen Colonies , led the war for independence from Great Britain , and built a frame of government for the new United States of America upon republican principles during the latter decades of the 18th century. Most Founding Fathers at one point considered themselves British subjects , but they came to understand themselves more as patriotic Americans who possessed a spirit distinct from that of their motherland. The group was composed of businessmen , lawyers , philosophers , politicians , plantation owners and writers from a variety of social, economic, and ethnic backgrounds. The Founding Fathers came from a variety of occupations, and many such as, John Adams , a lawyer; Charles Carroll of Carrollton , a planter; and Benjamin Rush , a doctor had no prior political experience. Historian Richard B. Franklin, Hamilton and Jay were leading opponents of slavery.
The conflict between Britain and its colonies in America had escalated beyond just taxation. The colonies were looking for representation in the British Legislature but were denied that right. - As neither man has been expunged from history, it is interesting to consider the nine months they spent together in Paris , a time when they renewed the relationship begun in the Continental Congress of and when the younger Jefferson again had the opportunity to work closely with Franklin, seasoned veteran of international diplomacy, science, and letters. When Jefferson arrived in August to assist in the negotiation of commercial treaties, Franklin had been in France for more than seven years.
The Committee of Five of the Second Continental Congress was a group of five members who drafted and presented to the full Congress what would become America's Declaration of Independence of July 4, This Declaration committee operated from June 11, , until July 5, , the day on which the Declaration was published. The delegates of the Thirteen Colonies in Congress resolved to postpone until Monday, July 1, the final consideration of whether or not to declare the several sovereign independencies of the Colonies, which had been proposed by the North Carolina resolutions of April 12 and the Virginia resolutions of May During these allotted three weeks Congress agreed to appoint a committee to draft a broadside statement to proclaim to the world the reasons for the Colonies seceding from the British Empire. The broadside's final paragraph repeated the text of the Lee Resolution as adopted by the declaratory resolve voted on July 2. Because the committee left no minutes, there is some uncertainty about how the drafting process proceeded—accounts written many years later by Jefferson and Adams, although frequently cited, are contradictory and not entirely reliable.

domain: history


kern/88518: cannot mount root rw at boot
huntting at glarp.com
Sat Nov 5 00:30:16 PST 2005
>Synopsis: cannot mount root rw at boot
>Arrival-Date: Sat Nov 05 08:30:14 GMT 2005
>Originator: Brad Huntting
The machine in question has problems booting the 6.0-RELEASE 'boot-only' CD. But it can boot diskless over the network.
The procedure listed below works when installing 5.4-RELEASE, but not on 6.0-RELEASE. The problem is that the kernel is mounting the root partition readonly even when the root partition is an 'md' pseudo-device.
A hack in 5.4's kern/vfs_mount.c causes mountroot to use RW when mounting an md device. This appears to be missing in 6.0.
But what's more disturbing, is that the kernel flag (was it -w ?) for 'mount the root partition readwrite' appears to be missing in 5.4 and probably 6.0. This was a very usefull flag, did it change? Why was it removed?
Copy the 'boot-only' cd to a tftp- and nfs-exported directory and setup dhcp.conf accordingly. For example:
option root-path "pernicious.glarp.com:/scratch/diskless/FreeBSD/6.0R";
Assuming you have permissions set correctly in /etc/exports, and tftp enabled from /etc/inetd.conf, a machine which net-boot's should get thrown into the FreeBSD install procedure.
Either restore the -w flag (or make a kernel environment switch 'boot_readwrite'), or reinstitute the hack in vfs_mount.c that causes 'md' root filesystems to be mounted readwrite initially.
More information about the freebsd-bugs


text:
Street Photography Workshop
19th May 2013
Street Photography Workshop, Birmingham
Event Organiser: Matt and Pete’s Photo School
Cost: 50 GBP including VAT
Time: 1pm – 6pm
“Our Street Photography workshop starts by looking at Cartier-Bresson and The Decisive Moment before moving on to the broad church of photographing the urban human along with advice on how to be subtle, polite and bold in your pursuit of the perfect shot.
This five hour afternoon workshop involves a two hour practical workshop in and around Victoria Square followed by an intensive group critique of your photos back at base. The session is tailored to give you knowledge and insights which can be applied to your everyday shooting while giving you a taste for what’s possible with your camera and your eye.
For more information about this and other workshops see http://photo-school.co.uk/courses/photography-workshops/
Back to full listings


text:
Free forum : Xenosaga, Xenogears and Xenoblade fannage!
A RP forum group about mythical creatures who joins in a hidden society to protect the humans from ill-intended monsters, and monsters from ill-intended humans.
Student Community. Welcome to the Underground. Forum
Welcome to the Sports Talk Underground Network Community Forum.
Free forum : A great website for Animal Crossing players
Cyberfluo Chaos!. Punish Yourself - Le Forum. punish yourself vx punk cyberpunk indus fluo underground
The Gossip Column has gone underground
Vidz-Weiss. Vidz-Weiss: Underground Forum. Free forum,
Free forum : A FILIPINO FORUM COMMUNITY FOR SHARING AND LEARNING PURPOSES
The new new underground
Emcees, Artists, Poets
SBHS Underground is home to SBHS class of 2013, where we help eachother through the HSC Year.
Free forum : Central Headquarters for the Honor Society.
Free forum : High EXP, High Gold, Friendly GM's. Free forum : RAN-Underground
Forum free : This is a forum about Pokemon, the games manly but the animated series and card game is also talked about
We are a World of Tank Pinoy Clan in Eu server. We only got Pinoy members. Our motto is Aim Small, Miss small!
Free forum : The best game from SSB. Free forum : Smash Bros Underground
Home Of the UnderGround LeGendz PS3 Clan.
For a time, the humans of Sera knew peace... then Emergence Day came. The Locust horde arrived without warning, and countless horrors spilled forth from their underground burrows. The Coalition of Ord
Free forum : Welcome to RCU. A new place for cheaters, programer, coder and trainer maker!~this is currently under customisation. but please enjoy here
Ang Tambayan ng mga Certifide Pinoy Pasaway
Free forum : A place to discuss and exchange ideas freely without the fear of persecution.
Providing Pokemon strategies and a fun community since 2013.
Home of All Lolicore
Welcome to the rebel base. The Underground, where democracy reigns.
"Be nice to nerds, odds are you'll end up working for one" -Bill Gates
The Underground Circus, A place where misfits, rejects, and freaks alike turn to for snactuary and sanity under the authority of the a tsundere woman called 'The Circus Master' and her silent right-

domain: entertainment


text:
Welcome to Authors' Central
Please click here for information on Nova’s Publication Process and Timeline (Updated).
Please click here for Contact Information.
For Editors, Authors and Chapter Contributors
Permission to Reuse Nova Content
Please MAKE SURE to put the TITLE of the book or journal in the Subject line. Thank you!

domain: library


text:
CAFP investigates how, in the context of the Belt and Road Initiative, China’s global power is manifested, negotiated, and resisted in people’s daily life in a South-South setting using fashion as an exemplary case.
This project will theorise how fashion is created, circulated, valuated, and consumed in and through Global Souths Value Chains (Guangdong-Nairobi-Maputo), dissecting complex dynamics and expressions of power.
Picture from editorial feature in i-D Vice - fashion cities Africa: flying the flag for modern african fashion. Photography by Sarah Waiswa.
The surge of China’s global power has caught the interest of the general public, policymakers and scholars alike, often focalized in discussions about the Belt and Road Initiative (BRI) – the Chinese government’s ambitious global development strategy.
Picture from V&A’s Landmark ‘Africa Fashion’ Exhibition. Photography by Juergen Teller.
By the full-length research of the GSVC, the China Fashion Power project aims to positively impact economic and cultural development as well as the natural environment in the Global South.
Women and men pass a store in a market in Abidjan. Photography by Andrew Esiebo.
MEET THE TEAM
CAFP’s major contribution is threefold. Theoretically, it will move beyond a Western-centric epistemology to map the chains, restraints and materialities of China’s power expansion through fashion. Methodologically, this project will synergistically collect and triangulate empirical information along complete South-South commodity chains.

domain: geography


text:
AD While some people believe it’s never too early to start getting into the festive spirit; I’m not ready to start decking the halls in my own home just yet. But there is one lovely Danish tradition I whole heartily approve of: advent candles. Just as you would a traditional calendar, the advent candle, or … Read More about Nordic Inspiration – Advent Candles
With so many amazing interior launches in the last few weeks, as well as Maison et Objet and London Design Festival taking place; let’s just say September has been filled with new Nordic inspiration. I’ve already covered some of my favourite autumn-winter collections and there are more to come, but for this round up I … Read More about Nordic Inspiration – New lamp launches
AD The August Bank Holiday, the last weekend of summer, and why I usually spend these much-needed three days exploring new and exciting places.
After visiting the Top Drawer trade show in January, and following IMM Cologne, Maison & Objet and the Stockholm Furniture & Light Fair, it’s safe to say I’ve been totally inspired by this season’s new launches. Rather than feeling under pressure to completely redecorate my whole house, I personally prefer to update what I’ve already … Read More about Nordic Inspiration – Sculptural Accessories
Hej and Happy New Year! I hope you’ve all had a fantastic festive break. After what seemed like a relentless week of Christmas preparations and celebrations, my family and I finally got the rest and relaxation we very much needed by heading to Copenhagen for a few fun filled days. This was our first New … Read More about Nordic books to inspire you in 2019