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Offshore Mutual Funds
Many of our
clients are very interested in hearing about the investment
opportunities mentioned in our newsletters and daily
updates. Of course, some clients are unfamiliar with certain
types of investment terms, have a fear in general about
offshore investments, or simply are not aware of the mutual
fund investments that are available. The reality is that
well known companies such as Fidelity Investments,
Templeton, Alliance, and other very good investment firms
all offer tax-free offshore mutual funds. In addition,
there are also some excellent investments firms in countries
such as the UK and Luxembourg that offer mutual funds that
Americans especially have never heard of simply because
these firms really do not want to be bothered registering
them in the US. But, they can be sound additions to
your investment portfolio. In addition, keep in mind
that many of these kinds of mutual funds or investment funds
may also be available through a number of retirement annuity
products as well. There is one very good 100 plus year
old insurance company from Europe offering this very same
kind of opportunity, so they are out there if you know where
What Is A Mutual Fund?
Most American investors are very familiar with mutual funds, but for those that are not, here is a brief explanation. A mutual fund is basically a type of investment vehicle that allows individual investors with a like minded interest to pool their money and have the benefit of professional money management. The professional manager has the responsibility of selecting stocks, bonds or other investments that are consistent with the fund’s goal or objectives. As an example, investors participating in the GT Global Healthcare Fund are doing so because they want to own a portfolio of stocks involved in the healthcare industry. In reality, they are a part owner (along with the other fund investors) of a very large investment portfolio. The portfolio may be a collection of 50 companies worldwide that are involved in the healthcare industry. To duplicate such a portfolio themselves, investors would need to commit a great deal of time and capital. But, with an investment of only $25,000 in the fund, the investor has the benefits of instant diversification and the knowledge that a professional adviser is managing the portfolio for them. Naturally, the fund manager receives a salary from the mutual fund firm and may also receive a bonus that is directly related to how well he or she manages the portfolio for the investors. All mutual fund companies charge a management fee for the services they are providing. Even so-called no load companies are getting their money from somewhere.
equivalent British term to the American Mutual Fund is
Pooled Fund or Open Investment Trust. In reality, the
open-ended trusts that can be seen listed in the London
Financial Times are the same type of investment vehicles as
the American Mutual Fund. To be sure, there are many
more terms and detailed explanations that go along with
this. The purpose here is for the reader to have a
basic understanding of a mutual fund type of
investment. I also want you to be aware that there are
a number of investments in Europe that have a different
name, but in essence work the same way as something you are
very familiar with.
Why Are Offshore Mutual Funds Tax Free ?
Well, the explanation for this is quite simple. Just like some jurisdictions permit interest from bank accounts to be tax exempt, the same is true for mutual funds. Some of the more popular offshore mutual fund jurisdictions, such as the Cayman Islands, Bahamas, Bermuda, Channel Islands or the Isle of Man permit mutual funds to be exempt from local taxation as long as the investors are not residents of these locations. Mutual fund companies use this to their advantage. All of the well-known American mutual fund companies mentioned earlier have their funds registered and based in one of these locations. As an example, The Fidelity Investments Offshore North America Fund might be the very same fund as the popular Magellan Fund or Puritan Fund. The only difference is that the fund is domiciled and is operated offshore. As a result, there is no tax on capital gains or dividends for the shareholder.
Why Have You Not Heard Of These Investments Before ?
Three reasons: fear, aggravation and the S.E.C or Securities and Exchange Commission. The US Securities and Exchange Commission prohibits offshore or non-US registered funds from soliciting US investors. In theory, this is to protect US investors from unscrupulous and unregulated offshore fund companies and in my opinion is a valid regulation. The regulations and requirements in some jurisdictions regarding offshore fund companies range from a highly regulated environment to none at all. Investors therefore must investigate a fund company thoroughly and do their homework. There are some excellent companies operating offshore, such as Global Asset Management, Baring Asset management, Fidelity Investments, and then there are some crooks. You must certainly separate the good from the bad. In all honesty, there are also a number of very good trust or fund companies from Europe that simply do not want to be bothered with all of the paperwork and filing requirements of the S.E.C, just so they can market their funds in the US. Part of this also has to do with taxes. Many European funds operate on what is known as a roll-up basis. This means that capital gains and dividends are automatically reinvested back into the fund, pushing up the share price in the process. No distributions are actually made as with the US funds. These type of funds are actually tax deferred because, the investor does not have a tax consequence until they redeem their fund shares five years later, ten years later or whenever. You can be sure that the IRS does not like this arrangement and the European fund companies are not about to change the way they operate just to please the IRS. If you currently own shares in a US mutual fund, even if you request automatic re-investment of your capital gains and dividends, you know that your annual capital gains are reported and that you must pay tax on it. This is regardless of whether or not the actual share price of the fund has changed or whether or not you physically received a check from the fund. This has got to be one of the greatest tax scams in history and the IRS loves it. You are actually paying tax twice on your US mutual fund investment. Once every year that you own the fund and of course again when you redeem your shares.
The other reason that you may not have heard about these offshore funds is fear. Even though offshore funds cannot solicit US investors directly, US investors are certainly permitted to solicit them. Meaning, it is perfectly legal for you to own shares in any of the funds offered from Luxembourg, Isle of Man, Cayman Islands, Honk Kong and elsewhere. However, recent hassles or scare tactics regarding tax reporting issues and money laundering efforts have made many offshore fund companies refuse to accept American clients. This is especially true with the investment companies located in Europe. Most of these companies are tired of being harassed by the IRS or the SEC to cooperate with tax reporting or to turn over investor lists. If it is not a requirement in their own country, why should they do it just because 3% of their clients are American? It is unfortunate, but this is how the US government agencies have gotten around the constitution. It is far easier, and technically legal, to put the fear of God into a foreign company, so much so, that they will not take American clientele. Remember what I mentioned previously. However, it is perfectly legal for a US citizen to own shares in a foreign or offshore mutual fund, annuity or to have an offshore bank account. The problem today is finding a company that is not afraid of the IRS or the SEC and that will take an individual US citizen as a client. I do know of a few companies in Europe that will do it, but they are the exception to the rule.
How Can Investors Participate In An Offshore Mutual Fund ?
There are two problems that both can be addressed by using the Offshore Trust, Foundation or Company structure. One problem is something already discussed. That is the refusal of many offshore fund companies to take US citizens or residents as clients. While many firms have a fear about this, for the reasons discussed, they have absolutely no problem with a Trust or Non-US company as the shareholder or beneficial owner of the fund. So, while the US citizen is shunned, a Panamanian Corporation or Trust from the Bahamas is welcome with open arms as a shareholder. However, another option is of course for the investor to obtain another citizenship and another passport. In this regard, he or she would be investing individually (and not necessarily via an offshore company or trust) albeit as a citizen from another country (see our other articles about dual citizenship and obtaining a second passport).
The second problem US
investors have is taxes. Even if you find an offshore
mutual fund that will take you as a client, and while it is
perfectly legal under US law for you to own such an
investment, you still are required to pay tax to the US
government. This is true regardless of the fact that
there is no tax liability in the jurisdiction where the fund
is domiciled or if the fund is a SICAV or “roll-up” type
fund that does not make annual distributions. The
answer again is to own such an investment through a properly
arranged offshore entity. When you factor in the tax
savings, asset protection benefits and availability of some
excellent investment opportunities; Offshore Mutual Funds,
SICAV Funds, and Unit Trusts from the Isle of Man or the
Channel Islands are extremely appealing and offer the
possibility of returns not found in the North American


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Last month the head of Mercedes-Benz (whose HUGE volume dealership sits in Miami) issued an apology for using Che Guevara in a Mercedes ad campaign.
Now Ricky Martin (with many fans in South Florida–and poised to play a character named Che on Broadway’s Evita)–very carefully clarifies his role:
the Che he will play is not the iconic rebel Che Guevara. “I’m a character called Che, the voice of the people. Che in Argentina can be the taxi driver, the waiter, the bartender. I’m telling the story of Evita Peron. I’m the first person to sing in the musical and I deliver the last words.

domain: artistic


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Welcome to Tri-County Pediatric Associates. We are a group practice of two board-certified pediatricians, a family nurse practioner, and a dedicated support staff. For over 30 years, Tri-County Pediatrics has been caring for children from the day they are born until they reach adulthood. Many of our former patients now have families of their own and trust us to care for their children as well.
At Tri-County Pediatrics, your children will have the benefit of a primary care physician who will monitor your children through all stages of growth and development and provide care for acute illness.
A physician is on call to provide medical care for your child on the days when your primary care physician is not in the office. We provide after-hours support 24 hours a day, seven days a week.
Please call our office with any questions you may have or to schedule an appointment to meet one of our physicians. We look forward to meeting you and building a strong and trusted relationship with you and your children.
Well Child Exams provide you and your physician the opportunity to monitor your child's growth and development from birth until adulthood. At this visit you will have the chance to address any concerns you may have about your child and receive information about their continued development. Well Child Exams are an important part of your child's overall well being.
If you would like us to see more than one child, please schedule both of them when you make your appointment. Without an appointment, we may not be able to see a sick sibling right away, and you may be asked to wait while the provider sees a scheduled patient who may be waiting.
We are available to address urgent medical needs after regular office hours on Saturdays between 8:30 AM and 12 PM. Please call the main number at 781-344-3791, and remove any blocks on your phone prior to calling the office so that our physician may return your call. Save any routine questions, prescription refill questions, prescription refill requests, or cancellations for our regular office hours.
907 Sumner St., Suite M-102, Stoughton, MA 02072
Monday – Friday, 8:30 AM – 5 PM
Urgent care provided on Saturday from 8:30 AM - 12:30 PM

domain: medical


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Pinstripes and the Rise of Baseball Dynasties
The Yankees' success was not just about winning championships; it was about creating a baseball culture that resonated with fans worldwide. Their iconic pinstripes and the aura of success they exuded cemented their status as a team to be reckoned with, inspiring other teams to strive for greatness and establishing the concept of baseball dynasties.
The Yankees' Championship Rings: A Symbol of Baseball Excellence
The Yankees' championship rings, with their intricate designs and inscriptions, became coveted symbols of baseball excellence. These rings reflected the team's dominance and the legacy they were creating, inspiring generations of players and fans to dream of reaching the pinnacle of baseball success.
A Legacy of Pinstripes and Sporting Excellence
The 1950s New York Yankees left an indelible mark on the history of baseball and the tradition of championship rings. Their iconic pinstripes and unwavering pursuit of greatness continue to inspire generations of players and fans, and their championship rings remain enduring symbols of baseball excellence and the pursuit of sporting glory.

domain: history


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Simpsons Premium Adult Wet Dog Food (Chicken, Venison, Salmon and Herring) is a complete diet suitable for adult dogs of all breeds.
Made using only natural ingredients and no rendered meats, this diet is completely grain free, ideal for dogs suffering with allergies.
Free from artificial colours, flavours, and preservatives.
||0.5 - 1 Tins
||1 - 1.5 Tins
||1.5 - 2.5 Tins
60% Fresh Meat: Chicken 20%, Venison 20%, Salmon 10%, Herring 10%, Organic Potatoes, Organic Carrots, Organic Pumpkin, Organic Spinach, Vitamins and Minerals
Protein 10.9% Oil: 6.7% Fibre: 0.5% Moisture: 75% Ash: 2.5%

domain: pet


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. . . and what, for me, we can really count on.
"We lived in an efficiency at the Silver Sands Motel in Cocoa Beach the winter I was eight as we waited for our cement-block tract house to be built. At the motel entrance, a full-size cement dolphin rose continually out of the waves, the spotlight at night making shadows on the cement foam. My father would slowly drive his Chevy on the left side of the horseshoe-shaped patio court in the center to stop in front of our unit. Dim lights illuminated the walkway, and the ceaseless sound of surf, louder at high tide, more faraway at low, surrounded us. Next door lived a boy named Robin. I had never heard of a boy named Robin before, but he seemed intelligent, I thought, and his family had just moved there from New York, waiting for their cement-block tract house.
It was at the Silver Sands my mother admitted there was no Santa Claus. Robin and I had been talking about Santa’s existence, sitting on the rusting seats of the creaky motel swing set. Later when I was flipping through the toy section of the shiny Sears & Roebuck Christmas edition catalog, I started to wonder why there were price tags listed for all these toys if Santa Claus made them in his workshop and was going to bring them. I had already started to suspect that some things didn’t fit with the Santa Claus story, like the part about coming down the chimney since I didn’t see any chimneys at the motel or anywhere else in Cocoa Beach. And I’d heard rumors on the playground. I posed the question to my mother.
“That’s because mommy and daddy are really Santa Claus,” she said gently. “We buy all the toys and put them under the tree for you and Ricky. All the parents do. There is no real Santa Claus, honey.”
I felt a sick rush in my stomach. “That’s not really true,” I said in my know-it-all way. “You’re just saying that.”
“Really. It is,” she said flatly.
Why did I ask her that question? I scolded myself. Although I wanted her to answer, I didn’t really want to know, not yet, anyway. I ran out the jalousie-windowed front door and climbed onto the sea wall that separated the sand-ridden patio from the beach below. I swung my legs, my heels banging against the sea wall as I watched the winter-sized waves rolling in endlessly.
The waves seemed unconcerned about Santa Claus or any other human matter. There really is a Santa Claus, I told myself, trying to make time go backwards. But the longer I sat, I knew there was no going back. I could see the indifference of the waves to my small plight, and this somehow comforted me. They just carried on day after day, year after year, for eons."
(Excerpt from "Launched" in "Hullabaloo on the Space Coast: A Memoir of Place," copyright 2012 by Linda Buckmaster._

domain: literature


Fall is the very best time to garden in Central Texas. This is the best time of the year to plant shrubs and perennials, as well as many vegetables. By planting in the fall, your plants will have the time they need to grow strong root systems that will see them through the heat and drought of the next summer. This will often be the difference between failure and success in Texas gardening.
While it is still warm, you can plant warm-season vegetables such as peppers, squash and tomatoes. If you can find large transplants of these vegetables, you will give yourself the best chance of having a good harvest before the first frost.
Look for varieties that have shorter days to maturity if you cannot find large transplants. If you still have tomatoes and other vegetables that made it through the summer, you can keep them growing for fall. Peppers in particular are known to sit through our hot summers and then suddenly start producing once the first cool days of fall arrive.
Make sure all these vegetables receive adequate moisture if it does not rain. If the temperatures continue in the high 90s, you will need to check to see that the ground around them is moist 2 inches down. You can use your finger as your gauge – the soil should be moist, but not soggy. You may need to water deeply twice a week in very high heat, but as soon as the heat lessens, reduce watering to once a week. Brief, shallow watering only encourages the roots to stay near the surface where they will dry out more quickly and then die.
Once cooler weather arrives, you can plant fall vegetables — ones that you eat the leaves or roots. All varieties of greens, lettuces, carrots and beets should go in the ground once temperatures have moderated and we begin to have fall rains. They will grow all winter, giving you fresh vegetables right from your garden when they are almost impossible to find at the grocery store.
Fall flowers such as pansies, alyssum, dianthus and large transplants of mums can also be planted once the weather cools. They can take a freeze and will be much larger and more beautiful in the spring than any that were freshly planted.
Amend the Soil
With any planting that you do, add lots of compost to the soil to help keep it fertile and productive. This is especially important in our heavy clay soils which can compact down if not regularly renewed with mulch. You can add fall leaves to any bed that will not be used right away and they will break down by spring.
I also make sure to add a nitrogen fertilizer to planting beds in the fall. I recommend ammonium sulfate and use it religiously in my own gardens. As with any soil additive, follow the package directions for the amount to add.
Shrubs and perennials flowers should be planted once the weather has truly and finally cooled down — probably in mid-October. These should be planted in areas with enough drainage and in the type of sunlight needed for the species you are growing.
Ask your nursery worker for their recommendation on the light requirements. Be sure to give each plant enough room to stretch out to its mature size without crowding to prevent maintenance and health problems.
This practice will also save you money by cutting down on the number of plants you buy. I have seen many areas in Waco planted with two or three times as many plants in a bed as recommended. These beds will have to constantly be pruned and often develop root and leaf problems due to poor circulation and overcrowding.
Staying the Same
Another essential gardening practice to follow when planting anything bigger than a small annual is to plant at the same level the plant was growing in its pot. If you err, err on the side of higher than that level — never lower.
Also, if the roots have grown around the pot, uncurl them and spread them out — cutting them apart if necessary. Not spreading out the roots can cause a slow death to occur over the next two or three years as your plant slowly strangles itself.
Follow these rules and have a great fall garden. With the cooler weather and more abundant rains, it is a wonderful time to plant and enjoy the fruits of your labors.


Fibres are thread-like structures with thin, long, and flexible strands that can be broadly defined. Plants and animals are the two main sources of fibres. The fibre manufacturing process, as well as the components and coating chemistries used in the process, determine the fibre qualities.
Fibre reinforcement is the primary source of structural characteristics in composite materials. The fibre in a composite, held in place by the matrix resin, gives tensile strength to the final product, improving performance attributes such as strength and stiffness while reducing weight.


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Hardy Lloyd is a violent neo-Nazi that has been in and out of state and federal prisons for nearly two decades. He is a former leader of World Church of the Creator, also known as Creativity, a violent white-supremacist hate group that espouses antisemitism. In 2003, he was involuntarily committed to a psychiatric facility and kicked out of the organization.
In 2004, Hardy Lloyd was charged with killing a woman he met on an online dating site, 41 year old Lori Hann. He shot her in the head, stating he wanted to “to watch her die” to police. At the time of the shooting, watchdog organizations who track hate groups said they believed Lloyd had recently broken from one group to preach as a “lone wolf.” After police searched his home, they found dozens of books on Adolf Hitler and white supremacy, including “White Power.”
Shockingly, Lloyd was found not guilty in the killing of Hann when a jury found he was acting in self defense; he was however convicted of carrying a firearm without a license. He was ordered to serve 11 1/2 to 23 months in jail with three years probation.
After he was freed, Lloyd launched “Universal Fascism” whose stated goal was to “promote open and violent revolt against the Americans, the JEWS, the Economic Elite of the world, and Monotheism!” according to his now deleted website.
On his now-deleted website, Lloyd taunted the family of the woman he killed with song lyrics about getting away with murder. He titled one song “Bi*ch Killer”, a take on Ice T’s 1992 single “Cop Killer”.
In 2009, after three police officers were killed in the Pittsburgh area, Lloyd praised the murderer’s actions on his website, writing “We are meant to kill and die” and “Death to all white people and anglo-saxons”. Investigators found a picture on Lloyd’s blog of a shotgun, with the caption, “The best gun I ever used! No revolvers needed, babe!” That information was used as probable cause to conduct a search of Lloyd’s home, where investigators found 10 firearms, including two fully loaded handguns. He was charged with being a felon in possession of a firearm and was ordered to serve 30 months in federal prison to be followed by three years of supervised release.
Lloyd violated his release, and in 2016, he was sentenced to 14 more months in prison to be followed by 22 months of supervised release. The following year, he violated his release again by circulating antisemitic fliers in the Pittsburgh area and using computers to watch violent videos and order weapons; he was ordered to more prison time. During his bigoted and violent antics, he was caught trespassing Carnegie Melon University. Subsequently, he was cited and banned from their property.
Shortly after the Pittsburgh Tree of Life shooting massacre that left 11 people dead, Hardy Lloyd posted on social media, “Target: Jew Hill” — a reference to the Jewish neighborhood where the shooting occurred. After an assault weapons ban went into effect that year, he took to social media again, posting “Anyone who supports such laws must be targeted, and their families murdered. Lone Wolves GET BUSY.”
In August 2019 Hardy Lloyd was sentenced to two years in the federal lockup, for violating terms of his supervised release and posting the above online threats against Jews and gun-ban advocates, but was released just a year later on October 6, 2020. The Pittsburgh Jewish community has been informed by the authorities to stay vigilant. Hardy Lloyd’s unlawful and violent behavior remains a threat to our communities.
For those in the Pittsburgh Area – Stay Informed.
Report Any Suspicious Activity Here

domain: law


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- This event has passed.
The Eatery at The Grant House Tea Party
September 29, 2018 @ 12:00 pm - 3:00 pm UTC-7
Please join us on September 29, from 12 – 3 p.m., for our Tea Party event in conjunction with the Summer’s End Promenade presented by the Fort Vancouver National Historic Site.The street will be closed and National Parks Service volunteers will be strolling down Officers Row dressed in a range of period clothing illustrating the history of Fort Vancouver.
Indoor and outdoor seating is available (first come first serve on the outdoor seating as this will be the most popular to watch the parade). Reservations are required along with a credit card to hold the reservation (72 hour cancellation policy). Call today for your reservation: 360-906-1101.
For more information visit: https://eateryatthegranthouse.com/holiday-events/tea-party/.


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Baltimore Hip Hop's Online Destination for Self-Made Entrepreneurs
Dj Fallen is a producer and dj from Seattle, Washington this girl from Tinder (lol) put me onto. He produces music of all types, but he has a unique sound that sounds like Warehouse EDM, Rap, and Metal, bore an interesting af baby.
Check out his tracks, support the artist, and stay tuned because I got an interview in the works.
This was written by Petaluma Al Harrington, creator of the Hip Hop blog curatedflame.com


CSR E and CSW drilling templates
Attached you will find two drilling templates to mount the Forza Motorsport CSR Elite Wheel and the ClubSport Wheel to a cockpit or Wheel Stand.
Both wheels come with an adapter unit which makes the wheels compatible to the mounts of the Porsche wheel series.
If you want to mount it on a table you need to get the ClubSport table clamp. This will give you a rock solid mount with adjustable angle.


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Please enter "what" you're searching for
Try searching for businesses with Foreign Exchange in their name.
We found 3 results for Foreign Exchange in Sandringham
and have expanded the location search out to include an additional 33 results
Servicing; Balmoral, Manukau, Manurewa, Avondale, Mount E...
Relianz Forex Ltd is a One Stop Foreign Exchange service provider who is committed to provide Exceptional Service to its customers. The company is ...
Shop 355, St Lukes Shopping Centre Mt Albert Auckland
586A Sandringham Rd Sandringham Auckland 1025
WSD House 475 Mt Eden Rd Auckland 1024
Shop 3 955 New North Rd Mt Albert Auckland 1025
4/32 Mahuhu Cre Auckland Central Auckland
BETTER RATES. ZERO FEES. Currency Online offers the best deal for your global money transfers and international payments. Transact 24 hours a day at your ...
Ground Floor 52-64 Victoria St Auckland Central Auckland ...
25B Queen St Auckland Central Auckland
175 Queen St Auckland Central Auckland
155 Queen St Auckland Central Auckland 1001
Level 8 220 Queen St Auckland Central Auckland 1010
Shop 3, 44-52 Wellesley St Auckland
UNIT GD NEW PRESIDENT HOTEL INSIDE CITY 27-35 Victoria St...
290 Queen Street, Inside City Convenience Auckland
11 Customs St East Auckland Central Auckland
Level 1/239 Queen St Auckland Central Auckland
Shop 41, Sylivia Park Mall 286 Mt Wellington Hwy Mt Well...
Level 4 99 Queen St Auckland Central Auckland 1010
Auckland Central Auckland 1010
Level 2, 52 Swanson St Auckland Central Auckland 1010
Can't find what you're looking for?
= Required Information

domain: geography


EINHELL GH-DP 7835 SUBMERSIBLE DIRTY WATER PUMP
The dirty water pump GH-DP 7835 is a powerful and effective device
It convinces by its great flow and its impeccable operation when extracting the dirty water of house, garden, ponds and wells.
With a power of 780 W, this efficient pump is capable of extracting a volume of dirty water of up to 15,700 liters per hour.
Its infinitely variable water level detector allows you to select between a continuous operating mode and a predetermined level for its connection and disconnection.
The long life housing of the GH-DP 7835 pump is made of impact-proof plastic and withstands high wear and tear.


An anti-poverty agency serving the residents of one of Cleveland’s poorest neighborhoods is planning a $20 million investment to replace its h…
Search / 5 results found Showing: 5 of 5
Walk The Vue at Green Road and Chagrin Boulevard and you’ll feel like you’re at a resort. Once summer comes and the pool opens, it’s sure to fill up fast.
There’s a two-level fitness center. There’s that big, heated outdoor swimming pool. There is concierge service. There are different kinds of relaxation spaces, from intimate conversation pits to a green where people can sit and meditate. There’s yoga.


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Synopses & Reviews
Mike Royko pulled no punches. A hardnosed reporter with a keen sense of social justice and a murderous pen, he became, in Jimmy Breslin's words, "the best journalist of his time." Royko was by all accounts a difficult man, who would chew out his assistants every morning and retire to the Billy Goat Tavern every night. But his writing was magic. No one captured Chicago like Mike Royko. No one wrote with his honesty, his toughness, his passion, and his humor.
In this, the first comprehensive biography of one of the most important Chicagoans of the century, Dick Ciccone, a long-time colleague and editor of Royko's at the Chicago Tribune, captures Royko at his best and at his worst. We see Royko sweating over columns minutes before deadline. We see him romancing his wife. We see him torturing his legmen. We see him barbequeing ribs and riffing on politicians.
Mike Royko was the most widely read columnist in Chicago history. His column was syndicated in more than 600 newspapers across the country. With 7500 columns spanning four decades, Royko's writing reflects a radically changing America. Royko not only tells the story of one of America's greatest newspapermen, but also explores the dramatic changes in journalism and in American society over the course of the twentieth century.
No one captured Chicago like Mike Royko of the "Chicago Tribune". In this, the first comprehensive biography of one of the most important Chicagoans in history, Ciccone not only tells the story of the great newspaperman but also explores the dramatic changes in journalism and in American society over the course of the 20th century. of photos.

domain: library


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The good news is regular meditation may help you calm down and drift off. So it pays to incorporate a little mindfulness into your routine. To keep things simple, you can even meditate lying down in bed.
How to Meditate in Bed
Meditation can calm your mind and body for better sleep when you're ready to hit the hay. But technically, you're not supposed to fall asleep while you're meditating.
We're pro‐sleep at GhostBed, so we say more power to you if you've found a reliable way to drift off. But if you want to meditate by the book, you'll need to be mindful of staying alert.
For that reason, the biggest factors to consider while meditating in bed are your posture and position.
Can You Meditate Lying Down in Bed?
The answer is yes, you absolutely can meditate lying down. Some folks even believe it's beneficial because it elongates your spine and promotes energy flow.
Lying down can be especially conducive to certain types of meditation, like body scans and diaphragmatic breathing.
Plus, sometimes meditating lying down is unavoidable. Maybe you're sick, have an injury that makes sitting up painful or you're simply exhausted.
If that's the case, you can still do your best to stay alert while lying down with the following tricks:
- Bend your knees with your feet hip‐width apart.
- Bend your arms at the elbow with your hands pointing toward the ceiling.
- Make sure you're lying on your back and your head is supported with a pillow.
- If you prefer, you can also use a wedge, bolster or blankets and pillows to elevate your body on an incline.
Experiment to see what feels best for your unique body as you meditate.
Is it Bad to Meditate Lying Down?
Lying down to meditate is not bad. Mindfulness can be practiced in any posture, including walking, standing, sitting and lying down.
That said, if you're lying down on a gel memory foam mattress while you meditate, chances are you're going to conk out.
If you find that you're unintentionally drifting off every time you meditate lying down, try sitting up in bed.
Seated Meditation Posture
If you choose to sit up in bed, here's the proper way to position yourself:
- If it's comfortable, cross your legs. Sitting cross‐legged is relaxing, but it requires a little effort from your body to stay stable and upright. This helps you remain alert. (If crossing your legs hurts your knees, hips, or back, please don't push yourself through the pain! Sit in whatever manner is comfortable for your body.)
- Close your eyes or shift to an “unfocused gaze.” The most common way to meditate is with your eyes closed, but some folks don't feel comfortable with that—and that's okay! You can also use an “unfocused gaze.” To do this, allow the muscles around your eyes to relax and soften your gaze on something straight in front of you. (Don't overthink it!)
Once you get into a comfortable position, meditating in bed is just like meditating anywhere else. Here's how to do it:
- Tune into your breath. Begin by drawing attention to your inhales and exhales. You don't need to breathe differently than you normally do; just pay attention to what you're doing. If you have trouble focusing on your breath, try noticing the feeling of air entering and leaving your nostrils or the rise and fall of your chest.
- Notice your thoughts as they come up. Here's one truth about meditation: your mind will wander. Pulling your focus away from your thoughts and back to your breath is what meditation is all about! With time, you'll find your thoughts drift a little less.
- Do a body scan. If following your breath isn't your jam, you can also do a body scan. To do this meditation practice, you can begin at your head or your toes. It's up to you. Tune into the sensation (or lack thereof) you're feeling in every body part. Don't forget smaller parts like your eyes, tongue and jaw. Sometimes we hold the most tension in these spots.
The goal of a body scan is not to change anything about your current experience. Noticing tightness in your stomach, for example, may lead you to unclench your muscles, but that's not a requirement of the practice.
Benefits of Meditating in Bed for Sleep
As we've mentioned, meditation is not meant to put you to sleep. (Although sometimes it does happen this way!) Instead, you can think of your meditation practice like a healthy workout routine.
You wouldn't expect to fall asleep in the middle of your 5‐mile run, but you know running releases stress and regulates your body in ways that help you fall asleep later in the day. It's a similar story to meditation.
For example, Evan, one of our GhostBed team members, meditates to stay present and focused on what's important, but he's noticed that when he's in that state, he sleeps better too.
This is in part thanks to the effects meditation has on the hormones that regulate sleep. A regular mindfulness practice reduces cortisol, elevates melatonin and balances serotonin, putting you in the optimal state for a good snooze.
Boost Your Benefits With Massage
For many people, meditating (in or out of bed) can be an important puzzle piece to getting a good night of sleep. But it may not be enough on its own to help you drift off.
While meditation relaxes your mind, your body may still be wound up from a stressful day, preventing you from getting shut‐eye. This is where the GhostBed Massage can help.
The only mattress of its kind, the GhostBed Massage uses soft, flexible air cells to gently stretch and massage your entire body, helping you release pent‐up tension. Combined with meditation, it's likely to help you fall asleep in record time. It's the level-up for your wellness routine you don't want to skip.

domain: psychology


text:
An art piece with a purpose, the Cyan Design Anemone Container will look great on your kitchen counter or dining room table. This container features a wiry metal construction that allows a peek at whatever you’d like to display. The minimalist metal design blends well with modern, rustic, and industrial décor.
20.25 diam. x 11H in.
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domain: design


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By Peter Slowick
In 1999, as I turned 40 years old, I was thinking a lot about making the second half of my life meaningful. I had observed that the greatest musicians I had worked with (YoYo Ma, for example) or the greatest historical musicians (Fritz Kreisler, Pablo Casals) were all great human beings – full of love and empathy for others. The mission statement of a new organization came to me – born fully grown, like Athena leaping out of the head of Zeus: “Develop the Gift of Music, Acknowledge God as the Source of the Gift, and Respond in Service to Others.”
This new organization, which I named Credo, was intended to start as a summer chamber music program focused on the highest level of performance, combined with serving others with music and physical labor.
Within weeks of incorporating Credo, I was invited to join the faculty of Oberlin Conservatory. The Oberlin ethos was at one time summarized with the expression “Do you think one person can change the world? So do we.”
As I look back over what has happened with Credo in our 16-year history, I am convinced that anyone with a good idea, a passion and determination to succeed, and great friends can indeed leave the world a significantly changed place.
Credo is a complex amalgam that could be best described using the words: excellence, love,intensity, fun, accountability, friendship, devotion, and joy. Check out our web presence at Credo-music.org to see the array of programs all built around our mission statement. Or you might want to watch this short video:
Credo has accumulated about two thousand alumni, who range in age from 10 years old to mid-thirties. They hail from 40 states and about a dozen foreign lands. They populate principal chairs in youth orchestras, at major conservatories such as Oberlin, Eastman, Colburn, etc. They have participated in Credo “mission” trips to Los Angeles, and generated their own trips in response to the Japan tsunami and the Haiti earthquake. They come from a variety of backgrounds, but are united in their belief in music as a significant agent of positive change – and a voice for powerful messages from a God that is greater than we can conceive.
In 1999 we started with 27 students, for two weeks in Woodstock, Illinois. In 2015, we’ll have about 80 students for 3 weeks at Oberlin Conservatory, another 50 for chamber music in Chicago in July, about 25 at a Flute Intensive program, another 40 or so playing the Brandenburg Concerti in Orchestra Hall, Chicago, and Severance Hall, Cleveland. As I write this, I’m in Brisbane, Australia, where I’m just completing two weeks of Credo activity here that touched several hundred students here and in Sydney. Additionally, we have several hundred individuals and families from around the world that follow our Credo blog at Credo-music.org/blog. We’re excited to see what the next 15 years bring – growth seems to be exponential in the world of Credo! We’re thrilled that what started with one crazy person (me!) has so many people working together to change the world.
So, my message to you is – whatever your vision, whatever your passion with music – pursue it with all your heart and energy. Based on my experience, YOU can be a person who changes the world!
Peter Slowik has devoted his life to sharing his passion and understanding of music as a performer and teacher. In addition to his current positions as Professor of Viola at Oberlin Conservatory and Artistic Director of Credo, he’s taught at Cleveland Institute, Eastman, Indiana University, and Northwestern University, and performed with Chicago Symphony and with numerous notable chamber music colleagues.


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Tonight I am writing about a concert instead of being AT at concert. No it is not the same. No it doesn’t make up for it. I was going to go see the symphony perform live (and free!) in the park, but we had crazy storms this evening and for some reason I still haven’t purchased a lawn/folding chair and I really didn’t want to sit on my blanket on the sopping wet ground… so lots of excuses later, I ended up not going. Oh well. I saw the symphony earlier this year and that is enough to hold me over till the next time, right? Maybe?
Anyway, I need to give a little background before I start talking about the most recent concert that I went to. My friend Allison is awesome. She was the first person that I met in college, she is my favorite road trip buddy, and she and I have very similar taste in music. She has introduced me to some of my very favorite singers and musical groups and Nickel Creek is one of those groups. They have a really fun folksy, bluegrassy sound (if you love the mandolin you will love them) and their 3 part harmonies make every song really easy to sing along to. Allison and I recently took a mini road trip to Kansas City to see them perform and it was awesome!
Nickel Creek released a new CD this last year (so good!) and went on this tour to celebrate their reunion AND 25 years of making music together. Wow! In case you haven’t listened to them before, I have compiled a list of my personal favorites. Enjoy!
On a completely unrelated side note, a transformer blew today at work and the power went out and we got to leave early! Hooray! The power went out while I was eating a piece of ice cream cake (don’t worry, I managed to finish the cake in complete darkness) and it was kind of fun just sitting around and talking with my coworkers in the dark for a few minutes! But I work in a basement. With no windows or outside light. It was seriously dark. And kind of creepy. That is all.

domain: hobby


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Family parks in Jeddah, where it has many sites for entertainment and recreation and enjoyment for children and adults alike, including amusement parks, parks and other places of entertainment.
Table of Contents
- Family parks in Jeddah ..
- Family parks in Jeddah jeddah .. Jeddah Oasis for Recreational Sciences ..
- Sail Island in Jeddah ..
- Waterfall amusement in Jeddah ..
- The village of Jungle Land in Jeddah ..
- Atallah Happy Land Jeddah Park ..
- KidZania …
- Nemo ..
- Ice Land Jeddah ..
- Aqua Park Jeddah Water Park …
- Chuck’s Cheese in Jeddah …
- Friends Forum Center …
- Fakieh Aquarium …
- The little designer ..
- Fortex (Mall of Arabia) ..
Family parks in Jeddah ..
Family parks in Jeddah jeddah .. Jeddah Oasis for Recreational Sciences ..
Jeddah Oasis for Recreational Sciences .. Family parks in Jeddah jeddah..It is considered one of the best family parks in Jeddah, and it refers to modern concepts in Arab countries that explain education in very entertainment ways. The Oasis of Entertainment Sciences includes 6 different halls, including the human body lounge and a hall specializing in wonders Hydro, Air and Aeronautics Hall, Mathematics and Physics Science Hall, and a hall that includes future scientists. Each of the halls contains scientifically modeled models to facilitate scientific information, and it is worth noting that it contains rare information of its kind. The Jeddah Oasis for Recreational Sciences is considered one of the most popular sites, as it is considered a beacon of science and culture as it allows for a sense of experience and self-exploration of science.
Sail Island in Jeddah ..
Al-Shiraa Island in Jeddah .. Family parks in Jeddah jeddah The island is one of the most beautiful family parks in Jeddah, and it is located in the city of Jadina overlooking the Red Sea coast. And Al-Shiraa Island is covered with huge natural green areas, around which a number of Trabizas have been covered with roofs made of white sails That gives the place a pleasant aesthetic view. Many tourists and city residents on the island, especially families with children, accept the island because there are many swimming pools and water games that children love and are attracted to.
Waterfall amusement in Jeddah ..
Waterfall amusement in Jeddah .. .. Family parks in Jeddah jeddah There are amusement parks on the coast of the Red Sea, “Jeddah Corniche”, where the amusement parks reach an area of about 60 thousand square meters, and many changes and developments have been made recently, in order to be one of the most important theme parks In Saudi Arabia, Al Shallal Theme Park Jeddah is one of the best family parks in Jeddah, it contains many fun games that add a feeling of happiness and joy to adults and children alike.
The village of Jungle Land in Jeddah ..
Jungle Land Village in Jeddah .. Family parks in Jeddah jeddah The village of Jungle Land Jeddah opened in the year 1999 and this village was called the bushland, and it was prepared with all capabilities and modern facilities, to become one of the most important family parks in Jeddah. The village witnesses a distinct turnout from tourists and visitors residing in the town Also, the village has an African character.
Atallah Happy Land Jeddah Park ..
Atallah Happy Land Jeddah. Family parks in Jeddah jeddah is one of the most important family parks in Jeddah, as it attracts thousands of visitors from families, as it includes entertainment games and entertainment facilities at a high level of modernity at the Kingdom level. Atallah Entertainment Park was established in 1986 as one of the entertainment sites of importance in Jeddah, as it was attached to the renewal in 2008, then it was opened again to the public in 2010, as it was attached to many modern games, including the giant wheel, roller coaster and other games.
It is considered one of the major recreational gatherings, which aims to improve the skills and personality of the child, and to form relevant personalities in society.
A place designated for children’s swimming in the heart of a garden and a café that provides excellent services for families, waiting for children, located in Prince Fahd Bin Faisal Street, behind the Tawheed Mosque in Jeddah.
Ice Land Jeddah ..
Ice Land Jeddah … Family parks in Jeddah jeddah is one of the best family parks in Jeddah that is preferred and accepted by all children of the city of Jeddah, as well as visitors from abroad as well. The center is considered the first harmonic entertainment center for children and adults alike, as it includes a huge of games that he loves Children and adults. The place occupies a vast area, and it consists of many levels spread around games and shopping stores that belong to important international brands, as well as restaurants that offer delicious cuisine. This center is considered one of the most important family parks in Jeddah, as it is the first and most huge of its kind not Just In the Arab Gulf region, but in the entire Middle East.
Aqua Park Jeddah Water Park …
Aqua Park Jeddah Water Park … Family parks in Jeddah jeddah is located to the north of Jeddah on the Medina road to Dhahban, and is one of the best family parks in Jeddah, where a family resort includes amusement and water games enjoyable for all members of the family as it contains a group of restaurants with a distinctive African character.
Chuck’s Cheese in Jeddah …
Chuck’s Cheese in Jeddah .. Family parks in Jeddah jeddah is one of the most important family parks in Jeddah that are located in the direction of the Corniche, and many visitors come to enjoy it and have fun. Chuck Cheese is extensively present in many Arab and Western countries where there are about 524 branches that follow This amusement park includes a group of games and restaurants that serve visitors and tourists with the best and finest transactions and a wonderful affair. The Cheesecake in Jeddah includes many electronic games and video games that provide advanced joy and happiness, in addition to electronic hand games ie It is manually controlled and there are also hand games.
Friends Forum Center …
Multaqa Al-Asdiqa Center .. Family parks in Jeddah jeddah The center displays all sports, educational and recreational activities for children in one place and provides a healthy healthy environment. The center provides the needs of the mother and child in an integrated and coordinated way in Jeddah, where it provides all services to children and families, as it works to show talents and develop Innovations in many sports and intellectual fields in order to form a responsible personality with a leadership and constructive role in society.
Fakieh Aquarium …
It is a water fish park located on the Jeddah Corniche, suitable for families, and includes many restaurants that offer delicious food and all tastes.
The little designer ..
It is a club for children to develop skills and encourage the child to think and be creative in design and decoration, as it is located in Al-Faihaa – Abdullah Al-Suleiman Street in Jeddah.
Fortex (Mall of Arabia) ..
Furtex (Mall of Arabia) … Family parks in Jeddah jeddah Children amusement includes many games to spend a fun and entertaining time for the child, in addition to a group of different restaurants that offer delicious specialties.


Spring has sprung! There's no better time to get outside and enjoy some much-needed fresh air with the whole family. Here are a few family-friendly activities for everyone to enjoy:
- Go on a nature walk: Grab the whole family and go for a stroll. Explore your neighborhood and visit a new park or conservation area that you've never been to before. You can create a scavenger hunt for your kids to get them excited about exploring nature and new places. The first one to find a butterfly, a flower and a feather is the winner!
- Plant a garden: Now is the time to start planting your favorite flowers, fruits, veggies and herbs. Whether you want a bountiful harvest of tomatoes, potatoes, strawberries and squash, or you want to start a bit easier with some basil or mint, growing your own produce is a great interactive learning activity for your kiddos.
- Have a picnic: Pack up your children's favorite snacks, plenty of napkins, hand sanitizer, and a blanket or towel and head to your favorite park. Your little ones will enjoy the soft green grass and the gentle springtime breeze. Get your vitamin D for the day, but don't forget sunscreen!
- Go on a bike ride: For older kids, learning to ride a bike is an exciting and highly anticipated adventure. Once they're ready to go with a helmet, knee pads, elbow pads and training wheels, the opportunities for fun are endless. Try going to a park or community area at first to avoid cars and busy roads.
- Visit a local zoo or farm: Lions, tigers and bears — oh my! Any animal-loving little ones will love the opportunity to see their favorite critters in person. Many zoos have new baby animals around springtime, which is always exciting! Visiting a nearby farm is a great way to learn more about local agriculture with your children.
- Visit a local farmer's market: When you can, try to support local! If your green thumb isn't quite up to snuff, farmer's markets are a great place to purchase fresh produce. Some markets will even have made-to-order food, handmade goods and more! Many farmer’s markets are WIC-approved as well. Check with your local government program to see if there are any available near you.
- Visit a nearby lake or beach: If you're lucky enough to live near a pond, lake or beach, take advantage of it! Spring is the perfect time to sign up for swimming lessons before the summer rush begins. Older children may enjoy learning how to fish while younger ones can try building a sandcastle on the shore.
- Have a family game or craft night: If springtime is still chilly where you live, you may not be able to spend much time outside yet. Not to worry — there is still plenty of fun to be had! Have everyone pick their favorite board game or a new crafting project to start and spend some quality family time indoors.
Spring is a wonderful time to try something new. Whether it’s planting something new in your garden or your child’s first time riding a bike — embrace the season of new beginnings!


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23-year-old Ghanaian singer and actress, Yaa Jackson has opened up on her journey to motherhood.
Yaa Jackson welcomed her first child with her boyfriend, known as Manuel on January 5, 2023.
In an interview with Blogger ZionFelix, the actress revealed that she wasn’t aware she was pregnant till the fifth month of her pregnancy.
“My bump wasn’t really bulging. I was performing at events until 7 months. I discovered that I was pregnant when the baby was five months,” she said
Asked whether she would have aborted the baby if she noticed it earlier,Yaa Jackson replied in the negative and said she’ll never hurt an innocent child because she doesn’t know what he or she would become in the future.
Sharing her experience of becoming a mother, the Kumawood actress said she encountered challenges.
“It wasn’t easy at all. I urge every man to respect every woman. I nearly gave up on pushing the baby out. It can only be God. What helped me is that the midwife is a God-fearing woman. She was singing worship songs and praying the whole time I was in labour,” she said.

domain: celebrity


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Genome-Wide Association Study Meta-Analysis of the Alcohol Use Disorders Identification Test (AUDIT) in Two Population-Based Cohorts.
ABSTRACT: OBJECTIVE:Alcohol use disorders are common conditions that have enormous social and economic consequences. Genome-wide association analyses were performed to identify genetic variants associated with a proxy measure of alcohol consumption and alcohol misuse and to explore the shared genetic basis between these measures and other substance use, psychiatric, and behavioral traits. METHOD:This study used quantitative measures from the Alcohol Use Disorders Identification Test (AUDIT) from two population-based cohorts of European ancestry (UK Biobank [N=121,604] and 23andMe [N=20,328]) and performed a genome-wide association study (GWAS) meta-analysis. Two additional GWAS analyses were performed, a GWAS for AUDIT scores on items 1-3, which focus on consumption (AUDIT-C), and for scores on items 4-10, which focus on the problematic consequences of drinking (AUDIT-P). RESULTS:The GWAS meta-analysis of AUDIT total score identified 10 associated risk loci. Novel associations localized to genes including JCAD and SLC39A13; this study also replicated previously identified signals in the genes ADH1B, ADH1C, KLB, and GCKR. The dimensions of AUDIT showed positive genetic correlations with alcohol consumption (rg=0.76-0.92) and DSM-IV alcohol dependence (rg=0.33-0.63). AUDIT-P and AUDIT-C scores showed significantly different patterns of association across a number of traits, including psychiatric disorders. AUDIT-P score was significantly positively genetically correlated with schizophrenia (rg=0.22), major depressive disorder (rg=0.26), and attention deficit hyperactivity disorder (rg=0.23), whereas AUDIT-C score was significantly negatively genetically correlated with major depressive disorder (rg=-0.24) and ADHD (rg=-0.10). This study also used the AUDIT data in the UK Biobank to identify thresholds for dichotomizing AUDIT total score that optimize genetic correlations with DSM-IV alcohol dependence. Coding individuals with AUDIT total scores ?4 as control subjects and those with scores ?12 as case subjects produced a significant high genetic correlation with DSM-IV alcohol dependence (rg=0.82) while retaining most subjects. CONCLUSIONS:AUDIT scores ascertained in population-based cohorts can be used to explore the genetic basis of both alcohol consumption and alcohol use disorders.
Project description:Alcohol consumption has been linked to over 200 diseases and is responsible for over 5% of the global disease burden. Well-known genetic variants in alcohol metabolizing genes, for example, ALDH2 and ADH1B, are strongly associated with alcohol consumption but have limited impact in European populations where they are found at low frequency. We performed a genome-wide association study (GWAS) of self-reported alcohol consumption in 112 117 individuals in the UK Biobank (UKB) sample of white British individuals. We report significant genome-wide associations at 14 loci. These include single-nucleotide polymorphisms (SNPs) in alcohol metabolizing genes (ADH1B/ADH1C/ADH5) and two loci in KLB, a gene recently associated with alcohol consumption. We also identify SNPs at novel loci including GCKR, CADM2 and FAM69C. Gene-based analyses found significant associations with genes implicated in the neurobiology of substance use (DRD2, PDE4B). GCTA analyses found a significant SNP-based heritability of self-reported alcohol consumption of 13% (se=0.01). Sex-specific analyses found largely overlapping GWAS loci and the genetic correlation (rG) between male and female alcohol consumption was 0.90 (s.e.=0.09, P-value=7.16 × 10-23). Using LD score regression, genetic overlap was found between alcohol consumption and years of schooling (rG=0.18, s.e.=0.03), high-density lipoprotein cholesterol (rG=0.28, s.e.=0.05), smoking (rG=0.40, s.e.=0.06) and various anthropometric traits (for example, overweight, rG=-0.19, s.e.=0.05). This study replicates the association between alcohol consumption and alcohol metabolizing genes and KLB, and identifies novel gene associations that should be the focus of future studies investigating the neurobiology of alcohol consumption.
Project description:We evaluated the efficacy of a brief motivational intervention (MI) counseling in reducing alcohol consumption among persons living with HIV/AIDS in Kampala, Uganda. Persons living with HIV/AIDS with Alcohol Use Disorders Identification Tool (AUDIT) score ?3 points were randomized to either standardized positive prevention counseling alone or in combination with alcohol brief MI counseling. The mean change in AUDIT-C scores over 6 months was compared by treatment arm. The mean (standard deviation [SD]) AUDIT-C scores were 6.3 (2.3) and 6.8 (2.3) for control and MI arms ( P = .1) at baseline, respectively, and change in mean AUDIT-C score was not statistically different between arms over the 6 months ( P = .8). However, there was a statistically significant decrease in mean AUDIT-C score (-1.10; 95% confidence interval: -2.19 to -0.02, P = .046) among women in the MI arm. There was a nondifferential reduction in alcohol consumption overall, but MI appeared effective among women only. Studies with more than 1 counseling session and evaluation of gender differences in treatment response are needed.
Project description:BACKGROUND:Frequency and quantity of alcohol consumption are metrics commonly used to measure alcohol consumption behaviors. Epidemiological studies indicate that these alcohol consumption measures are differentially associated with (mental) health outcomes and socioeconomic status (SES). The current study aims to elucidate to what extent genetic risk factors are shared between frequency and quantity of alcohol consumption, and how these alcohol consumption measures are genetically associated with four broad phenotypic categories: (i) SES; (ii) substance use disorders; (iii) other psychiatric disorders; and (iv) psychological/personality traits. METHODS:Genome-Wide Association analyses were conducted to test genetic associations with alcohol consumption frequency (N = 438 308) and alcohol consumption quantity (N = 307 098 regular alcohol drinkers) within UK Biobank. For the other phenotypes, we used genome-wide association studies summary statistics. Genetic correlations (rg) between the alcohol measures and other phenotypes were estimated using LD score regression. RESULTS:We found a substantial genetic correlation between the frequency and quantity of alcohol consumption (rg = 0.52). Nevertheless, both measures consistently showed opposite genetic correlations with SES traits, and many substance use, psychiatric, and psychological/personality traits. High alcohol consumption frequency was genetically associated with high SES and low risk of substance use disorders and other psychiatric disorders, whereas the opposite applies for high alcohol consumption quantity. CONCLUSIONS:Although the frequency and quantity of alcohol consumption show substantial genetic overlap, they consistently show opposite patterns of genetic associations with SES-related phenotypes. Future studies should carefully consider the potential influence of SES on the shared genetic etiology between alcohol and adverse (mental) health outcomes.
Project description:Background:Alcohol dependence (AD) is a common disorder that is influenced by genetic as well as environmental factors. A previous genome-wide association study (GWAS) of the Korean population performed by our research group identified a number of genes, including BRCA1-associated protein (BRAP) and protein arginine methyltransferase 8 (PRMT8), as novel genetic markers of AD. Methods:The present investigation was a fine-mapping follow-up study of 459 AD and 455 non-AD subjects of Korean descent to determine the associations between BRAP and PRMT8 polymorphisms and AD. The Alcohol Use Disorders Identification Test (AUDIT) was administered to screen for the degree of AD risk in the subjects and 58 genetic variants, 5 for BRAP and 53 for PRMT8, were genotyped for subsequent association analyses. Results:In the present case-control analysis, BRAP rs3782886 showed the most significant association signal with a risk of AD (P=1.29×10-16, Pcorr =7.74×10-16, OR =0.19). There were also significant differences in the overall and subcategory scores for the BRAP genetic variants, including rs3782886 (P=9.94×10-31, Pcorr =5.96×10-30 at rs3782886 for the overall AUDIT score). However, the genetic effects of PRMT8 polymorphisms observed in our previous GWAS were not replicated in the present study (minimum P=0.0005, Pcorr >0.05, OR =0.30 at rs4766139 in the recessive model). Furthermore, the single-nucleotide polymorphisms of PRMT8 were not associated with the overall and subcategory AUDIT scores. Conclusion:The present findings suggest that the genetic variants of BRAP may contribute to a predisposition for an alcohol use disorder.
Project description:BACKGROUND:Genomewide association studies (GWAS) have begun to identify loci related to alcohol consumption, but little is known about whether this genetic propensity overlaps with specific indices of problem drinking in ascertained samples. METHODS:In 6,731 European Americans who had been exposed to alcohol, we examined whether polygenic risk scores (PRS) from a GWAS of weekly alcohol consumption in the UK Biobank predicted variance in 6 alcohol-related phenotypes: alcohol use, maximum drinks within 24 hours (MAXD), total score on the Self-Rating of the Effects of Ethanol Questionnaire (SRE-T), DSM-IV alcohol dependence (DSM4AD), DSM-5 alcohol use disorder symptom counts (DSM5AUDSX), and reduction/cessation of problematic drinking. We also examined the extent to which an single nucleotide polymorphism (rs1229984) in ADH1B, which is strongly associated with both alcohol consumption and dependence, contributed to the polygenic association with these phenotypes and whether PRS interacted with sex, age, or family history of alcoholism to predict alcohol-related outcomes. We performed mixed-effect regression analyses, with family membership and recruitment site included as random effects, as well as survival modeling of age of onset of DSM4AD. RESULTS:PRS for alcohol consumption significantly predicted variance in 5 of the 6 outcomes: alcohol use (?marginal R2 = 1.39%, ? area under the curve [AUC] = 0.011), DSM4AD (?marginal R2 = 0.56%; ?AUC = 0.003), DSM5AUDSX (?marginal R2 = 0.49%), MAXD (?marginal R2 = 0.31%), and SRE-T (?marginal R2 = 0.22%). PRS were also associated with onset of DSM4AD (hazard ratio = 1.11, p = 2.08e-5). The inclusion of rs1229984 attenuated the effects of the alcohol consumption PRS, particularly for DSM4AD and DSM5AUDSX, but the PRS continued to exert an independent effect for all 5 alcohol measures (?marginal R2 after controlling for ADH1B = 0.14 to 1.22%). Interactions between PRS and sex, age, or family history were nonsignificant. CONCLUSIONS:Genetic propensity for typical alcohol consumption was associated with alcohol use and was also associated with 4 of the additional 5 outcomes, though the variance explained in this sample was modest. Future GWAS that focus on the multifaceted nature of AUD, which goes beyond consumption, might reveal additional information regarding the polygenic underpinnings of problem drinking.
Project description:BACKGROUND:Current medications for alcohol use disorder (AUD) have limited efficacy and utilization. Some clinical trials have shown efficacy for gabapentin among treatment-seeking individuals. The impact of gabapentin on alcohol consumption in a more general sample remains unknown. METHODS:We identified patients prescribed gabapentin for ?180 consecutive days for any clinical indication other than substance use treatment between 2009 and 2015 in the Veterans Aging Cohort Study. We propensity-score matched each gabapentin-exposed patient with up to 5 unexposed patients. Multivariable difference-in-difference (DiD) linear regression models estimated the differential change in Alcohol Use Disorders Identification Test-Consumption (AUDIT-C) scores during follow-up between exposed and unexposed patients, by baseline level of alcohol consumption and daily gabapentin dose. Analyses were stratified by AUD history. Clinically meaningful changes were a priori considered a DiD ?1 point. RESULTS:Among patients with AUD, AUDIT-C scores decreased 0.39 points (95% confidence interval [CI] 0.05, 0.73) more among exposed than unexposed patients (p < 0.03). Potentially clinically meaningful differences were observed among those with AUD and exposed to ?1,500 mg/d (DiD 0.77, 95% CI 0.15, 1.38, p < 0.02). No statistically significant effects were found among patients with AUD at doses lower than 1,500 mg/d or baseline AUDIT-C ?4. Among patients without AUD, we found no overall difference in changes in AUDIT-C scores, nor in analyses stratified by baseline level of alcohol consumption. CONCLUSIONS:Patients exposed to doses of gabapentin consistent with those used in clinical trials, particularly those with AUD, experienced a greater decrease in AUDIT-C scores than matched unexposed patients.
Project description:BACKGROUND:HIV infected (HIV+) individuals may be more susceptible to alcohol-related harm than uninfected individuals. METHODS:We analyzed data on HIV+ and uninfected individuals in the Veterans Aging Cohort Study (VACS) with an Alcohol Use Disorders Identification Test-Consumption AUDIT-C score from 2008 to 2012. We used Cox proportional hazards models to examine the association between alcohol exposure and mortality through July, 2014; and linear regression models to assess the association between alcohol exposure and physiologic injury based on VACS Index Scores. Models were adjusted for age, race/ethnicity, smoking, and hepatitis C infection. RESULTS:The sample included 18,145 HIV+ and 42,228 uninfected individuals. Among HIV+ individuals, 76% had undetectable HIV-1 RNA (<500 copies/ml). The threshold for an association of alcohol use with mortality and physiologic injury differed by HIV status. Among HIV+ individuals, AUDIT-C score ?4 (hazard ratio [HR] 1.25, 95% CI 1.09-1.44) and ?30 drinks per month (HR, 1.30, 95% CI 1.14-1.50) were associated with increased risk of mortality. Among uninfected individuals, AUDIT-C score ?5 (HR, 1.19, 95% CI 1.07-1.32) and ?70 drinks per month (HR 1.13, 95% CI 1.00-1.28) were associated with increased risk. Similarly, AUDIT-C threshold scores of 5-7 were associated with physiologic injury among HIV+ individuals (beta 0.47, 95% CI 0.22, 0.73) and a score of 8 or more was associated with injury in uninfected (beta 0.29, 95% CI 0.16, 0.42) individuals. CONCLUSIONS:Despite antiretroviral therapy, HIV+ individuals experienced increased mortality and physiologic injury at lower levels of alcohol use compared with uninfected individuals. Alcohol consumption limits should be lower among HIV+ individuals.
Project description:BACKGROUND:Recently, an alcohol predictor was developed using DNA methylation at 144 CpG sites (DNAm-Alc) as a biomarker for improved clinical or epidemiologic assessment of alcohol-related ill health. We validate the performance and characterise the drivers of this DNAm-Alc for the first time in independent populations. RESULTS:In N = 1049 parents from the Avon Longitudinal Study of Parents and Children (ALSPAC) Accessible Resource for Integrated Epigenomic Studies (ARIES) at midlife, we found DNAm-Alc explained 7.6% of the variation in alcohol intake, roughly half of what had been reported previously, and interestingly explained a larger 9.8% of Alcohol Use Disorders Identification Test (AUDIT) score, a scale of alcohol use disorder. Explanatory capacity in participants from the offspring generation of ARIES measured during adolescence was much lower. However, DNAm-Alc explained 14.3% of the variation in replication using the Head and Neck 5000 (HN5000) clinical cohort that had higher average alcohol consumption. To investigate whether this relationship was being driven by genetic and/or earlier environment confounding, we examined how earlier versus concurrent DNAm-Alc measures predicted AUDIT scores. In both ARIES parental and offspring generations, we observed associations between AUDIT and concurrent, but not earlier DNAm-Alc, suggesting independence from genetic and stable environmental contributions. CONCLUSIONS:The stronger relationship between DNAm-Alcs and AUDIT in parents at midlife compared to adolescents despite similar levels of consumption suggests that DNAm-Alc likely reflects long-term patterns of alcohol abuse. Such biomarkers may have potential applications for biomonitoring and risk prediction, especially in cases where reporting bias is a concern.
Project description:Alcohol consumption level and alcohol use disorder (AUD) diagnosis are moderately heritable traits. We conduct genome-wide association studies of these traits using longitudinal Alcohol Use Disorder Identification Test-Consumption (AUDIT-C) scores and AUD diagnoses in a multi-ancestry Million Veteran Program sample (N?=?274,424). We identify 18 genome-wide significant loci: 5 associated with both traits, 8 associated with AUDIT-C only, and 5 associated with AUD diagnosis only. Polygenic Risk Scores (PRS) for both traits are associated with alcohol-related disorders in two independent samples. Although a significant genetic correlation reflects the overlap between the traits, genetic correlations for 188 non-alcohol-related traits differ significantly for the two traits, as do the phenotypes associated with the traits' PRS. Cell type group partitioning heritability enrichment analyses also differentiate the two traits. We conclude that, although heavy drinking is a key risk factor for AUD, it is not a sufficient cause of the disorder.
Project description:BACKGROUND:Since 2010 the National Institute for Health and Care Excellence has recommended screening adults for excessive alcohol consumption to try and help prevent alcohol-use disorders. Little is known about the extent to which these recommendations are followed, and the resulting completeness and validity of alcohol-related data recording in primary care. OBJECTIVE:To investigate the completeness and accuracy of recording of alcohol use within primary care records in the UK. DESIGN AND SETTING:Cross-sectional study in the Clinical Practice Research Datalink. PARTICIPANTS:We included all adult patients registered on 1st January 2018 with ?1 year of follow-up. PRIMARY AND SECONDARY OUTCOME MEASURES:We calculated prevalence of alcohol consumption recording overall and within patient groups. We then validated alcohol consumption data against recommended screening tools (Alcohol Use Disorders Identification Test (AUDIT)) as the gold standard. We also calculated how prevalence of alcohol recording changed over the preceding decade. RESULTS:In 2018, among 1.8 million registered adult patients, just over half (51.9%) had a record for a code related to alcohol in the previous 5 years. Recording of alcohol consumption was more common among women, older people, ex-smokers and those from more deprived areas, who were overweight/obese, or with comorbidities. A quarter of patients had units per week recorded in the last 5 years, but <10% had an AUDIT or Fast Alcohol Screening Test (FAST) alcohol screening test score. The recorded alcohol measures corresponded to results from gold standard AUDIT scores. The distribution of consumption among current drinkers was similar to the Health Survey for England. CONCLUSIONS:Half of adults in UK primary care have no recorded alcohol consumption data. When consumption is recorded, we have demonstrated internal and external validity of the data, suggesting greater recording may help identify opportunities for interventions to reduce harms.


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US Weekly Lets Loose New Single “American Piss” Before LP Release
US Weekly has been banging around the Austin live music circuit for the past year, emitting nihilistic punk diddies while their fans craved an official release. The time has come, April 22nd marks the release of their self-titled debut LP on Night Moves Records. The quartet’s first single “American Piss” is a commentary on the police shooting of Tamir Rice in 2015 and the general social injustices that pervade contemporary America. Heaving a nice dollop of grunge on top of their punk stylings, US Weekly sounds like a burgeoning Pissed Jeans or Metz coming to fruition in Austin. US Weekly launches a ten date East coast tour on May 10th and will be ripe for festival season in Austin as they ride the momentum of their first official release.

domain: entertainment


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Hold and hand luggage must not exceed certain weight and sizes. Please check with your airline for more information.

domain: travel


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Like all New Yorkers, Muslims are living in a climate of fear. Federal and local officials warn that the war in Iraq has increased the chances of a terrorist retaliation here at home.
But as they feel the threat of the attack on their home in the United States, they must also cope with feelings of watching their native region being bombed overseas.
On top of this, Muslims here have had to deal with an anti-Islamic backlash that began after September 11th, and has the potential to be reignited in this current climate. The Department of Homeland Security has been accused of unfairly targeting Arabs and Muslims with new immigration regulations.
More than anything, Muslims in Queens are being mindful of their safety, aware that the war in the Middle East has opened the possibility of being in harm’s way at home. Through all of this, they try to go on with life as normally as possible.
At the Razi School in Woodside, all outside activities and field trips have been canceled. A letter from the State Department of Education has advised private schools in New York to keep their students indoors for safety precautions.
“We worry that if our students are not contained inside, we may not be able to protect them as well, so all activities outside of school have been canceled until further notice,” said Azam Meshkat, assistant principal at the Razi School.
Meshkat said that the school has also tightened security, keeping a closer eye on who enters the building. All doors to the school are kept locked during the day, and the alarm system remains set.
“We have conducted evacuation drills with the students to make sure that they know what to do in case of an emergency,” Meshkat said. “It’s not fun.”
The school also has counselors on hand so that if students have any problems, there is someone on hand for them to talk to. The faculty at the school has talked about the war in Iraq with their classes.
“We have explained to them in a very blunt manner about the war,” Meshkat said. “They are exposed to it on television once they leave school, so we had to do it just as it’s done on T.V. It’s as uncomfortable for them as it is for us.”
None of the students have reported hearing any taunts, or encountering physical abuse from other people. However, both Meshkat and another faculty member have been subjected to slurs since the war broke.
Meshkat heard insults while she was riding the train to Woodside from her home in Long Island.
“Some comments were made directly to me, but that is understandable because we are living in very intense times,” she said. “What is needed is a little bit of understanding by everyone right now.”
The Manhattan-based Asian American Legal Defense and Education Fund has accused the Bureau of Citizenship and Immigrant Services of bringing Pakistani and Saudi Arabian boys into its office “for fingerprinting, photographing and interrogation under oath, usually without the presence of an attorney.” The BCIS office is a component of the Department of Homeland Security.
The defense fund has also accused BCIS of detaining or initiating people for deportation. The BCIS has instituted a special registration program for male nationals from Middle Eastern countries, that has also come under harsh criticism.
Although many Muslims in America—and in Iraq—want to see Saddam Hussein and his regime taken out of power, there is a disagreement how they believe it should be done. Some have expressed support for the war, while others have condemned it.
Sheikh Fadhel Al-Sahlani, president of the Al-Khoei Muslim Center in Jamaica, has said in published reports that he supports the current war. The center is home to an estimated 50 Iraqi families.
However, Mohammad Sherwani, director of the Muslim Center of New York in Flushing, is a strong opponent of the war against Iraq by the United States and its allies.
“It’s an unjust war,” he said. “Everybody hates Saddam and everybody wants the regime to be taken out, but people should be given the chance to do it on an international level, through dialogue and the United Nations.”
The Muslim Center of New York, which has been in Flushing for 30 years, held an open house last weekend as a way to bring the entire community together to get to know one another. It was an effort to open its doors to the non-Muslims in Flushing.
The center has not beefed up security at its facility, but Sherwani said his people have a good relationship with police in the area, and is confident they will be there if something should happen.
“We also put our trust in Allah,” he said. “The community has been very cooperative, and on the surface there are no problems so far.”
As he watches the conflict in the Middle East on television, Sherwani said he can’t help but feel that the “war has defeated the peace.”
“Baghdad is burning and it’s not just the buildings, it’s also the people who are burning,” he said. “People are innocent. People are people. We should not de-humanize human beings. War is always bad. It means death and destruction. We pray for the soldiers and for the people living there.”

domain: sociology


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Miami Dade Association of Health Underwriters
February 11 Seminar provides insight on new Section 125 Rules and provide CE credits for HR and CPA professionals.
The Miami Dade Association of Health Underwriters is hosting a 3 hour CE course on the new Section 125 Rules. Credit hours are HRCI approved as well as approved for continuing education credits for CPA's. Meetings are held at the Miami Springs Country Club. Sessions start at 9AM and will conclude at noon. Lunch will follow.
For more information, please contact:
President - Miami Dade Association of Health Underwriters


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Aditya Birla Bizlabs to help start-ups scale-up in a controlled business environment
In order to collaborate with start-ups and provide them opportunities to scale up in a large operating business environment, Aditya Birla Group announced the launch of Aditya Birla Bizlabs. Aditya Birla Bizlabs is a 20 day program enabling start-ups that provide innovative solutions in fields like - Retail, Financial Services and Mobility, amongst others to collaborate with the Aditya Birla Group. These are also the industries where the group enjoys leadership positions via its businesses such as Idea Cellular, More, Pantaloons, Madura Fashion & Lifestyle and Aditya Birla Financial Services.
The start-ups can leverage the Group's reach and business expertise to scale up in a ready and operating business environment. The Aditya Birla Group is in the league of Fortune 500, with $41 billion in size. Over 50 per cent of its revenue flows from its overseas operations spanning 36 countries.
Commenting on the same lines, Dev Bhattacharya, Executive President, Aditya Birla Group, said, “Our objective at Aditya Birla Bizlabs is to enable the start-up ecosystem with the power and reach of the group’s businesses to create a platform to foster growth and rapidly scale-up businesses."
BizLabs’ core programme will provide selected start-ups an opportunity to interact with CXOs and business teams who will give them industry insights, enabling them to develop a plan to scale up their business. In addition, the selected start-ups will have the opportunity to scale up by entering into a commercial arrangement with the group’s businesses. They may also receive an investment from an independent arm of the Aditya Birla Group.
Apart from Aditya Birla group, there are many other companies who have taken similar initiatives to encourage and provide opportunities to start-ups. Recently, Tracxn, in June this year, announced that it would launch an incubator called TracxnLabs, which would invest $20,000 to $50,000 in various start-ups. Similarly, Cisco and GSF joined hands to launch an accelerator programme for start-ups in the month of February this year. The programme would focus on both software and hardware platforms.

domain: news


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Founded in 1993, directed by professor Alina Orraca and integrated by music professors, students and amateurs performers, the Schola Cantorum Choralina is currently part of the Cuban Institute of Music, belonging to the Ministry of Culture National Center of Concert Music.
The Schola Cantorum Choralina has a broad repertoire of choral music, performed in a great numbers of styles embracing from Renaissance to modern music. Likewise, it has widely disseminated not only Cuban and Latin American popular and folk choral repertoire, but also original works composed by authors from this region and cult music.
Choralina has performed in countless recitals and concerts, also participating in festivals, congresses, fairs and exhibitions held in Cuba at the most important halls of the country, such as the Amadeo Roldán Theater, the National Theater, the Minor Basilica of San Francisco de Asís, the Museum of the Revolution, the Conf erence center, the Havana Great Theater, the Dolores Hall in Santiago de Cuba, among others. Choralina has also successfully participated in several editions of the International Choral Festival held in Santiago de Cuba city.
In 1994, Choralina visited Venezuela to participated in the "Vinicio Adames" 5th ChoralFestival and in the 5th International Encounter of Afro-Caribbean Music. Since then, the project included the creation of an UNESCO club aimed at promoting the peace and human fraternity ideals. To this end, Choralina has launched a significant cultural work in Havana, with 10 Children Choirs directed by Choralina´s own members.
In 1996, together with the National Symphonic Orchestra, Choralina performed at the première of Anton Bruckner´s Psalm 150, conducted by the French Jean Penin. That same year, they accompanied Cuban singer Augusto Enríquez during his concert given together with English musician Philip Manzanera. Some months later, it participated in the concert given by the renowned Cuban singer Argelia Fragoso.
In 1997, to commemorate the bicentennial anniversary of Franz Schubert, sponsored by the Austrian Embassy, Choralina gave several concerts performing, for the first time, some works composed by Schubert, like "El gran Halleluja", "Salve Regina", and "Domine non sum dignus", together with the "Cuerdas Diapasón" Quintet.
In December 1997 they toured through the State of Sao Paulo, in Brazil, giving concerts in different cities like Sao Paulo, Campinas, Ribeirao Preto, San Carlos, Santos Catanduva, among others.
On January 25, 1998, together with the Great Archdiocesan Choir in Havana and with the National Symphonic Orchestra, they sang the Mass presided over by H..S. John Paul II at the José Martí Revolution Square in Havana, conducted by Alina Orraca. That same afternoon, the Schola Cantorum Choralina was selected to perform the Chants for the Celebration of The Word Liturgy, presided over by His Sanctity at the Cathedral of Havana.
Between the months of May and July that same year, they made a successful tour through Spain and Italy, singing at the main theaters, squares, auditoriums and cathedrals of the most important Spanish cities: Madrid, Barcelona, Córdoba, Sevilla, Oviedo, León, Santiago de Compostela, Ferrol, Lugo, Astorga, Tarragona, Badajoz and Jerez, witnessed the success of this choral ensemble.
During the tour, in June 10 they participated as the main choral ensemble at the Public Audience by the Pope in San Pedro Square, in Vatican City. After its performance, they were received by His Sanctity in a lovely and unforgettable meeting. They were invited to participate in the Corpus Christi Mass, presided over by H..S. John Paul II in June 11 at the Basilica of San Juan de Letrán, also celebrated by all the Cuban Bishops then visiting the Holy See.
In October 1998 they met the famous pianist Daniel Barenboim at the Higher Institute of Art in Havana, receiving his tokens of recognition.
As part of the 1999 CUBADISCO Festival, the Schola Cantorum Choralina gave a concert together with other popular singers who performed works of its repertoire. Anabel López, Pedrito Calvo (then a member of the popular "Los Van Van Orchestra") and Jorge Luis Rojas, "Rojitas", were the guest artists who participated in that unique concert where the most rigorous choral work merged with the interpretation of those popular musicians.
Between the months of July and August 1999, Choralina toured again through Spain, including cities like Salamanca, Oviedo, Barcelona and Palafrullel, being granted, at Torrevieja, the Habaneras Third award during the 45 Habaneras and Polyphonies Contest.
Together with Coralina, the Spanish actress Lola Herrera gave a concert interpreting Federico García Lorca's poetry, besides presenting some poems fron Nicolás Guillén performed by the Choir voices.
Likewise, Coralina successfully participated at the 5th International Choral Festival held in Santiago de Cuba, where it was called "the most acclaimed choir at the Festival" according to critics in a press release.
In March 2000, Coralina performed for the first time the full score of John Rutter´s Magnificat and, later on, together with the "Alejo Carpentier" Young Symphonic Orchestra, they participated at the premiere of the Third World Symphony, by the Spanish composer Miguel Bermejo, presented at Amadeo Roldán Theater.
In May 2000, Coralina interpreted the "Carmina Burana" cantata, by Carl Orff, together with the National Symphonic Orchestra conducted by Master Leo Brouwer.
In July that same year, at the Alejandro García Caturla Hall of the Amadeo Roldán Theater, this choral group gave a series of Sunday concerts dedicated to children, with the participation of its cantorías and instrumentalists. Another remarkable moment was the selection of Ariel Hernández (tenor soloist) as member of the World Young Choir sponsored by the International Choral Federation.