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A predictive and prognostic model for hepatocellular carcinoma with microvascular invasion based TCGA database genomics
BMC Cancer volume 21, Article number: 1337 (2021)
Microvascular invasion (MVI) adversely affects postoperative long-term survival outcomes in patients with hepatocellular carcinoma (HCC). There is no study addressing genetic changes in HCC patients with MVI. We first screened differentially expressed genes (DEGs) in patients with and without MVI based on TCGA data, established a prediction model and explored the prognostic value of DEGs for HCC patients with MVI.
In this paper, gene expression and clinical data of liver cancer patients were downloaded from the TCGA database. The DEG analysis was conducted using DESeq2. Using the least absolute shrinkage and selection operator, MVI-status-related genes were identified. A Kaplan-Meier survival analysis was performed using these genes. Finally, we validated two genes, HOXD9 and HOXD10, using two sets of HCC tissue microarrays from 260 patients.
Twenty-three MVI-status-related key genes were identified. Based on the key genes, we built a classification model using random forest and time-dependent receiver operating characteristic (ROC), which reached 0.814. Then, we performed a survival analysis and found ten genes had a significant difference in survival time. Simultaneously, using two sets of 260 patients’ HCC tissue microarrays, we validated two key genes, HOXD9 and HOXD10. Our study indicated that HOXD9 and HOXD10 were overexpressed in HCC patients with MVI compared with patients without MVI, and patients with MVI with HOXD9 and 10 overexpression had a poorer prognosis than patients with MVI with low expression of HOXD9 and 10.
We established an accurate TCGA database-based genomics prediction model for preoperative MVI risk and studied the prognostic value of DEGs for HCC patients with MVI. These DEGs that are related to MVI warrant further study regarding the occurrence and development of MVI.
Hepatocellular carcinoma (HCC) is the sixth most common malignant cancer and the third most common cause of cancer-related death worldwide . With advances in surgical technology, partial hepatectomy and liver transplantation are the most commonly used elective curative treatments . Unfortunately, approximately 70% of HCC patients have a recurrence within the first 5 years after R0 liver resection , which has seriously limited the prognosis of HCC patients. It is, therefore, necessary to find selective genetic biomarkers that can identify aggressive behaviour and predict early tumour recurrence after liver resection and transplantation.
Microvascular invasion (MVI), defined as the invasion of tumour cells in the intrahepatic portal vein or hepatic vein branches, has generally been considered as one of most vital risk factors for the overall survival (OS) and recurrence-free survival (RFS) rates of postoperative HCC patients [4,5,6]. Previous studies have shown the prevalence of MVI in specimens obtained from LR or transplantation to be between 15.0 and 57.1% . The presence of MVI is a histopathologic feature that indicates aggressive behaviour of the HCC and predicts a worse prognosis of patients after R0 LR. Even for patients with small HCCs or those treated with transplantation or LR, MVI still increases the rate of tumour recurrence and dramatically shortens long-term survival .
Until now, the diagnosis of MVI has only been determined by histologic examination of the surgical specimens obtained after LR or transplantation [7, 9, 10]. The influence of the diagnosis on preoperative decision making is limited. An accurate preoperative estimation of MVI presence can help hepatic surgeons choose appropriate surgical procedures for patients based on risk-benefit assessment . Hence, many efforts to obtain a preoperative estimation of MVI have been made over the past decade . Recent studies reported that imaging may play an important role in preoperative prediction of MVI [12,13,14]. Based on some radiomics signatures, a radiomics nomogram showed a favourable predictive accuracy for MVI status in patients with HBV-related HCC . The use of serum or tumour biomarkers to estimate MVI risk has also been proposed [16, 17]. Unfortunately, these serum markers can also be abnormally high in patients with benign liver disease. Another predictive model that incorporates factors associated with MVI based on preoperative clinicopathologic data was reported . However, all the available models failed to examine the patients’ genetic changes related to the occurrence and progression of MVI. Owing to this lack of a specific and practical genomics predictive method, the development of a predictive model that incorporates genetic changes associated with MVI becomes desirable. Additionally, it is vital to screen genes associated with MVI and confirm their prognostic value for exploring the deep mechanism of occurrence and progression of MVI.
To our knowledge, we have established the first genomics prediction model, based on the TCGA database and patients’ sample validation, for preoperative MVI risk estimation in HCC. In addition, we first screen out genetic changes associated with MVI and confirmed the prognostic value of these for HCC patients with MVI. Further study concerning the occurrence and development of MVI is warranted.
Materials and methods
Data collection and pre-processing
The mRNA raw count profiles of HCC patients were downloaded from TCGA dataset (https://tcga-data.nci.nih.gov/tcga/). A total of 374 HCC patients’ samples and 50 control samples were available in TCGA, and the full clinical dataset also was downloaded. Simultaneously, the count data were normalized using the VST algorithm implemented in DEseq2 package.
The differentially expressed genes (DEGT-N) in HCC samples and control tissues were identified using R package “DESeq2” with a cut-off of |log2-fold change| > 1 and Padj < 0.01 (P-value adjusted for multiple testing using Benjamini-Hochberg method) (see Fig. 1A).
Among 374 patients’ samples, after excluding the samples with missing vascular invasion status or macroscopic vascular invasion, 299 samples were included in this study for next analysis, consisting of 93 MVI samples and 206 non-vascular invasion. Among DEGT-N, the differentially expressed genes (DEGM-N) in the MVI samples and non-vascular invasion samples were identified using “DESeq2” R package with a cut-off of |log2-fold change| > 1 and Padj < 0.05.
Selection of MVI-status-related key genes
A logistical model was built using the least absolute shrinkage and selection operator (LASSO) algorithm. To find an optimal λ, 10-fold cross validation with minimum criteria was employed, and the λ with the smallest cross-validation error was chosen. Other parameters were set to default values. Finally, 23 key genes were identified, and the LASSO logistical regression modelling was performed using R package “glmnet”.
Construction and validation of the classification model
In machine-learning, the classification is considered as a supervised learning task of inferring a function from labelled training data. Random forest is considered as an appropriate classifier to handle large-scale dataset, especially for imbalanced dataset, because of its ability to provide an empirical approach to monitor variable interactions. In this study, we randomly divided the 299 samples into training datasets (N = 225) and test datasets (N = 74). Based on 23 MVI-status-related genes, random forest was adopted to construct the classification model in the training datasets, and a classification model was implemented using R package “caret”. The classifier was trained using the repeated (10 repeat iterations) 10-fold cross validation of training datasets, and their predictive performance was evaluated in the test datasets using area under ROC curve (AUC).
One-way ANOVA and survival analysis
We adopted one-way ANOVA to demonstrate the association between the MVI-status-related genes and the corresponding clinical features, and the statistical significance was shown by boxplot. Then, to evaluate the impact of MVI-status-related genes on MVI-HCC patient’s prognosis, the overall survival was analysed. Among 93 MVI-HCC patients, survival time was missing for one sample. We performed a survival analysis for the remaining 92 samples. Continuous variables were dichotomized for OS before the log-rank test using optimal cut-off values determined by the “surv_cutpoint” function of the “survminer” R package. We adopted “survival” package of R software for log-rank test and Kaplan-Meier survival analysis.
HCC tissue samples
Two hundred and sixty pairs of primary HCC tissues and their corresponding adjacent normal tissues were obtained from patients who underwent hepatectomy between February, 2002 and June 2006 at the Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China. All of the patients signed an informed consent. All of the patients met the following inclusion criteria and underwent tissue microarrays (TMA) analysis: (a) a definite clinical diagnosis and postoperative pathological diagnosis of HCC, (b) R0 resection of all patients based on histologic examinations, (c) complete clinicopathologic and follow-up data, (d) absence of distant metastasis, and (e) absence of treatment before surgery. Our study was approved by the Institutional Review Board of the Institute for Eastern Hepatobiliary Surgery Hospital, Second Military Medical University.
TMAs and IHC
The tissue microarray slides were stained using the semi-quantitative system according to the manufacturer’s instructions, with a rabbit polyclonal antibody (Abcam, ab90260, 1:100, Abcam, ab85698, 1:100). Multispectral images (8 bit) acquired by the Vectra platform (Perkin-Elmer, Waltham, MA) were processed with Nuance 30.0 software (Perkin-Elmer, Waltham, MA) to build unique spectral curves for each of the four chromogens, and then unmix the signals of multispectral images. Staining intensity as a measure of selected candidate gene expression was quantified by the optical density of the respective chromogen per unit area in pixels. Cells positive for selected candidate gene were counted by colocalization analysis using Inform TM 2.1 software. The following tissue cores were excluded from analysis: a) less than 5% epithelial component, b) significant tissue loss or folds, and c) images with more than 5% poorly segmented nuclei. The histological-score (H-score) was used to evaluate the staining intensity. For each observed tissue component, a summary value we refer to as H-Score was calculated.
All patients were re-examined for serum AFP levels, liver function, and abdominal USG once a month. Chest X-rays and contrast CT or MRI scan were performed every 2–3 months for monitoring recurrence. The overall survival (OS) was defined as the interval between surgery and the date the patient died. Recurrence-free survival (RFS) was defined as the interval between surgery and the date of recurrence . The OS and RFS were censored at the last follow-up visit (August 31, 2012) for surviving patients and those without recurrence. Micro-metastases were defined as tumours adjacent to the border of the main tumour that could only be observed under a microscope.
All statistical analyses were performed using SPSS 22.0 statistical software. A chi-square test was used to evaluate the association between the selected candidate gene expression level and the clinicopathological characteristics. We used the Kaplan-Meier method to evaluate the cumulative survival, and the significance of the differences was determined using the log-rank test. Furthermore, we used Cox multivariate regression analysis to determine the independent prognostic factors of HCC. The statistical results were considered significant at P < 0.05 and highly significant at P < 0.01.
Identification of DEGT-N and DEGM-N
A total of 4357 DEGT-N (3155 upregulated and 1203 downregulated genes) were identified for subsequent analysis at the threshold of |log2-fold change| > 1 and Padj < 0.01(see Fig. 1A). Overall, 223 differentially expressed genes (DEGM-N) between MVI samples and non-vascular invasion samples were identified from 4357 differentially expressed genes (DEGT-N) in the HCC samples and non-cancerous tissues (see Fig. 1B).
Identification of MVI-status-related key genes
We performed LASSO logistical regression to identify genes associated with MVI-status using DEGM-N. At the optimal λ = 0.0461 in LASSO logistical regression model, the 10-fold cross validation error was minimized (see Fig. 2A). LASSO coefficient profiles of the genes are shown in Fig. 2B. Finally, 23 key genes were identified based on their non-zero regression coefficients. Through screening the TCGA database, transporting subunit alpha 4 (ATP1A4), cystatin like 1 (CSTL1), forkhead box D3 (FOXD3), hypocretin neuropeptide precursor (HCRT), homeobox D10 (HOXD10), keratin 12 (KRT12), protocadherin alpha 1 (PCDHA1), scavenger receptor class A member 5 (SCARA5), solute carrier family 25 member 47 (SLC25A47), very low density lipoprotein receptor (VLDLR), adrenoceptor alpha 1D (ADRA1D), aldehyde dehydrogenase 3 family member A1 (ALDH3A1), chromosome 1 open reading frame 61 (C1orf61), calcium voltage-gated channel auxiliary subunit gamma 4 (CACNG4), CUGBP elav-like family member 5 (CELF5), homeobox D9 (HOXD9), keratin associated protein 5–7 (KRTAP5–7), nuclear pore complex interacting protein family member B13 (NPIPB13), opiorphin prepropeptide (OPRPN), olfactory receptor family 1 subfamily F member 1 (OR1F1), proprotein convertase subtilisin/kexin type 1 inhibitor (PCSK1N), thyroid hormone responsive (THRSP), and transmembrane serine protease 15 (TMPRSS15) were identified in HCC with non-MVI group and HCC with MVI group.
Building a classification model and validation
In this study, 299 samples were randomly divided into training datasets (N = 225) and test datasets (N = 74). Based on 23 MVI-status-related key genes, we performed a Random Forest machine learning approach to construct a classification model using training datasets. The test datasets were used to validate the predictive performance. The area under receiver operator characteristic curve (AUC) was used to assess the predictive performance of classification model. In our study, the area under curve (AUC) of random forest (RF) classification model reached 0.814 (see Fig. 3), demonstrating its good performance for classification.
One-way ANOVA and survival analysis
In this study, first, we calculated the statistical significance of the difference between the MVI-status and non-MVI-status. The result showed the expression level of 23 key genes had a significant difference (see Fig. 4). Additionally, the 92 MVI-HCC patients were divided into low-level group and high-level group according to optimal cut-off values of each hub gene, and the survival curve was plotted. We found the survival time of low level group was significantly longer than the high level group (see Fig. 5), indicating that nearly half of the key genes could act as prognosis biomarkers of MVI-HCC patients. The survival curve of the remaining thirteen genes was also plotted (see supplementary Fig. 1).
Validation group of two sets of HCC tissue microarrays
From screening the TCGA-database, we distinguished 23 differential genes in HCC patients with non-MVI group and HCC patients with MVI group. We validated two differentially expressed genes, HOXD9 and HOXD10, and explored their prognostic value for HCC patients with MVI after liver resection, using two sets of 260 patients’ HCC tissue microarrays from XXX. To further confirm the expression of HOXD9 and HOXD10, we examined HOXD9 and HOXD10 expression in an HCC tissue microarray by immunohistochemical (IHC) staining. Based on the results of the HCC tissue microarray, HOXD9 and HOXD10 expression was higher in the HCC tissues with MVI (n = 140) than in HCC tissues without MVI (n = 120) (P < 0.001) (Figs. 6A, B and 7A, B).
The staining intensity of HOXD9 and HOXD10 expression was scored automatically with a Vectra2 system (Perkin Elmer, USA). According to the intensity score, the HCC patients with MVI were divided into two groups: HOXD9 and HOXD10 low (n = 70) and HOXD9 and HOXD10 high (n = 70). We explored the association between HOXD9 and HOXD10 expression and the clinicopathological features in 140 HCC patients. Moreover, we studied the association between the prognosis of HCC patients with MVI and the expression of HOXD9 and HOXD10. In Fig. 6C, D, we found that high HOXD9 high expression levels were associated with poor overall survival (OS) and recurrence-free survival (RFS) in 140 HCC patients with MVI. Similar results were obtained for HOXD10 (Fig. 7C, D). These results showed that HOXD9 and HOXD10 were upregulated in HCC tissues and that HOXD9 and HOXD10 overexpression affected the prognosis of HCC patients.
Microvascular invasion (MVI), also known as microvascular tumour thrombus, has been repeatedly and definitively confirmed as a poor prognostic factor of HCC tumour recurrence after R0 liver resection . Preoperative prediction of MVI and exploration of the genetic characteristics of HCC patients with MVI carry important clinical significance. However, most recent studies have examined the serological and imaging features of HCC with MVI and preoperative prediction of MVI [11, 19, 20]. In addition, the genomics characteristics of HCC patients with MVI and MVI related with oncogenes and suppressor genes are unknown.
In our study, we first screened for genes associated with MVI that were different from normal liver tissue and HCC without MVI based on the TCGA database and studied the prognostic value of these in HCC patients with MVI. We established a TCGA database-based genomics prediction model for MVI. These selected genes related with MVI warrant further study concerning the occurrence and development of MVI.
In previous studies, MVI was only identifiable under a microscope based on postoperative pathological diagnosis. Its presence has been confirmed as a poor prognostic factor of HCC recurrence and of the survival outcomes of HCC patients.
The influence of the diagnosis on preoperative decision making is limited. If liver resection is considered for patients with a high risk of MVI, then a wide resection margin might be the preferred procedure with curative intent [5, 6, 21, 22]. Recent studies have mainly focused on the imaging and serological characteristics of HCC patients with MVI and ignored the genetic changes in these patients. A radiomics nomogram for preoperative prediction of MVI risk in hepatitis B virus-related HCC was reported . This nomogram integrated radiomics signature with radiologic features and AFP level to further improve its predictive accuracy for MVI. Another nomogram for preoperative MVI risk estimation in HCC based on preoperative clinicopathologic data was also described . However, recent studies related with MVI have important limitations. The genetic differences among normal tissue, HCC without MVI tissue, and HCC with MVI tissue remain unknown. Based on the above reasons, basic research about the genetic characteristics of occurrence and progression of MVI has been limited. We screened for genes from TCGA databases with distinct differences between HCC with or without MVI to search for these genes that may play an important role in the occurrence and development of MVI. Furthermore, we established TCGA database-based genomics prediction model of MVI and explored the prognostic value of 23 genes related to MVI for HCC with MVI, validated with two tissue chips of 260 patients.
In recent studies, a nomogram for preoperative estimation of MVI risk in hepatitis B virus-related HCC within the Milan criteria was established based on 7 factors: large tumour diameter, multiple nodules, incomplete capsule, α-fetoprotein level greater than 20 ng/mL, platelet count less than 100 × 103/μL, hepatitis B virus DNA load greater than 104 IU/mL, and a typical dynamic pattern of tumours on contrast-enhanced magnetic resonance imaging . This nomogram achieved concordance indexes of 0.81 (95% CI 0.78–0.85) and 0.80 (95% CI 0.75–0.86) in predicting MVI in the training and validation cohorts, respectively. Another radiomics nomogram for preoperative prediction of microvascular invasion risk in hepatitis B virus-related HCC, including the radiomics signature, nonsmooth tumour margin, hypoattenuating halos, internal arteries, and alpha-fetoprotein level, showed a favourable predictive accuracy for MVI status in patients with HBV-related HCC . However, our study examined the genomics changes of HCC patients with MVI, integrating 23 differentially expressed genes (DEGs) between HCC patients with MVI and without MVI, to predict the preoperative MVI risk with an AUC of 81.4%. This TCGA database-based genomics prediction model was more accurate in predicting the MVI risk than that of serological and imaging indicators.
No studies have examined the genetic changes for HCC patients with MVI. In our study, we first screened 23 DEGs in HCC patients with MVI and without MVI. These DEGs may be associated with the occurrence and development of MVI, and the genomic characteristics of MVI. Furthermore, we explored the prognostic value of 23 DEGs for HCC patients with MVI, validated by HCC tissue microarrays of 260 patients. Among DEGs, we selected homeobox (HOX) genes 9 and 10 to validate the expression and prognostic value of our screened DEGs. HOX genes encode a highly conserved family of transcription factors that significantly influence many cellular processes, including proliferation, apoptosis, cell shape, and cell migration. HOX genes contain a conserved 183 bp sequence and encode nuclear proteins called homeoproteins [23,24,25]. In neoplasms such as laryngeal squamous cells, HOX proteins participate in proliferation and oncogenic transformation [26, 27]. Studies have demonstrated the relation of HOXD9 to epigenetic control in development and diseases . Our study indicated that HOXD9 and 10 were overexpressed in HCC patients with MVI compared with patients without MVI, and patients with MVI with HOXD9 and 10 overexpression had poorer prognosis than patients with MVI with low expression of HOXD9 and 10. Similar results were obtained in previous studies. Lv et al. reported that HOXD9 promotes epithelial–mesenchymal transition and cancer metastasis by regulation of ZEB1 in HCC . In addition, MVI was regarded as an early biomarker of metastasis of HCC, indicating that HOXD 9 was related with the occurrence and development of HCC with MVI. Therefore, we screened 23 DEGs associated with MVI and identified genetics changes in HCC patients with MVI. In addition, the related genes of tumor microenvironment and presence of MVI should be further explored [30, 31].
This study has some limitations. First, we screened DEGs based on the TCGA database, which contains incomplete information about DEGs related with HCC patients with MVI. Second, we validated the prognostic value of two DEGs for HCC with MVI. However, all 23 DEGs should be incorporated in predicting the prognostic value of HCC patients with MVI. Finally, all 23 differentially expressed genes (DEGs) in HCC patients with MVI and without MVI for predicting the preoperative MVI risk need to be further validated in clinical practice.
In conclusion, we first screened for DEGs associated with HCC patients with MVI that were different from normal and HCC patients without MVI based on the TCGA database and studied and validated the prognostic value of these in HCC patients with MVI. We established a TCGA database-based genomics prediction model for accurately assessing the preoperative MVI risk. These DEGs related to MVI warrant further study of the occurrence and development of MVI.
Availability of data and materials
Availability of data and materials from TCGA dataset (https://tcga-data.nci.nih.gov/tcga/).
Differentially expressed genes
Receiver operator characteristic curve
Area under curve
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Ethics approval and consent to participate
The study was approved by the Institutional Review Board of Eastern Hepatobiliary Surgery Hospital and Chinese PLA General Hospital, and written informed consent was obtained from all patients for their data to be used in this research. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.
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Cite this article
Wang, J., Ding, ZW., Chen, K. et al. A predictive and prognostic model for hepatocellular carcinoma with microvascular invasion based TCGA database genomics. BMC Cancer 21, 1337 (2021). https://doi.org/10.1186/s12885-021-09047-1
- Hepatocellular carcinoma
- Microvascular invasion
- TCGA database
- Differentially expressed genes
- Prognostic value

domain: biology


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Landscape pieces exhibited at SAMA-Bedford | features
Picturesque landscapes are presented in a regional exhibition.
Landscapes from the Permanent Collection is in the Titelman Galleries and the Paula and Dean Lemley Gallery at the Southern Alleghenies Museum of Art, Bedford, Anderson House, 137 E. Pitt St.
The exhibition captures the development of the landscapes from the realistic to the painterly-abstract style. It shows works by artists of the 19th and 20th centuries such as Thomas Hart Benton, John Sloan, George Hetzel, Frederick Alan Counsel and Ron Donoughe.
“The history of landscapes is very interesting and has been around since ancient times,” said Kris Peterson, SAMA-Bedford Visitor Services representative.
“With landscapes, you can often be taken to places that you may not have seen before and you can get an idea of other people’s views. When you come in as a visitor to look at the landscapes, you see them from different perspectives. “
She said an example of seeing a landscape from a new perspective is “Blue Hills, Pennsylvania” by Counsel.
“The colors are pretty vivid, and if you’ve ever driven past the hills when they aren’t that bright blue, here in Pennsylvania we have a different perspective of these historic mountains,” said Peterson.
“The artist chose to paint them in a kind of illustrated way that you might see in a children’s book, which makes them very appealing. If you’re from Pennsylvania and you’ve seen these mountains, you may have seen them this way, so for some people it brings back memories. “
She said another piece on display, “Black Water” by Donoughe, takes her back to a time when she lived in Alaska.
“When I look at this painting, I miss Alaska a bit, so it brings back a memory and it’s nice to hopefully revisit those happy times in your life,” said Peterson.
The exhibition includes 35 works in media ranging from watercolor to oil and acrylic to pastel colors and ink to photography.
“There really is a lot of variety and that makes it interesting,” said Peterson.
When selecting pieces for the show, Peterson said, staff look for continuity, color, and emotion.
“When we put them together, we pay attention to the style,” she said.
“When choosing the pieces, you look for what could have a certain effect and what touches the people who come in.”
Peterson said the pieces are in the three rooms of the Titelman Galleries.
“The first gallery is filled with very colorful, Impressionist-style spring paintings,” she said.
“In the second gallery it’s more of a mountain landscape, and the colors are more beige and brown and earth tones.
“The last gallery is colorful with beautiful photographs as well as traditional paintings of garden landscapes with fields and meadows.”
In connection with the exhibition, works by the well-known Pennsylvania artist Edward J. Glannon are on view at the Paula and Dean Lemley Gallery.
“In his paintings we have a lot of clouds and valleys first and foremost, and I can imagine that this type of landscape would appear at the beginning of the 20th century.
“He really had that love of nature, and that’s what you get from his pictures. You can really feel what he wanted to show you. “
She hopes the exhibition will arouse the curiosity of viewers to go out and imagine their own landscapes.
“Go to the Blue Hills of Pennsylvania or Colorado and find your own scenery, appreciate the surroundings and the outdoors,” said Peterson.
The opening times of the museum are Tuesday to Saturday from 12 noon to 4.30 p.m.
Admission to the exhibition is free.
For more information call or visit 814-589-3020 www.sama-art.org.
Kelly Urban is a reporter for The Tribune-Democrat. She can be reached at 814-532-5073. Follow her on Twitter @ KellyUrban25.

domain: artistic


By Adam Hetrick
29 Oct 2013
|Photo by Joseph Marzullo / WENN|
Titled Get Back, the Spring Awakening and "Glee" star will take the stage at 7 PM for the concert at the Five Angels Theater that draws inspiration from his childhood. Musical direction will be by Mary-Mitchell Campbell.
Groff will be joined by a 52nd Street Project youngster and other special guests to be announced.
According to the 52nd Street Project, "Revisit that time of wild imagination, dress-up, sibling rivalry and humiliating home videos – you know, childhood… It's an evening of songs and reminiscences about the Broadway/TV/film star's 'let's put on a show in the barn' past."
Tickets start at $100. For tickets click here.
Founded by A Year With Frog and Toad co-writer Willie Reale in response to a deepening need to improve the quality of life for the kids of Hell’s Kitchen, the 52nd Street Project is dedicated to the creation and production of new plays for, and often by, kids between the ages of nine and eighteen that reside in the Hell’s Kitchen neighborhood in New York City. The Project does this through a series of unique mentoring programs that match kids with professional theatre artists.


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2018 Ventura Comedy Festival
The 2018 Ventura Comedy Festival will take place August 27 through September 2.
This will mark year 8 of The Ventura Comedy Festival. Produced by comedian, writer, and entrepreneur Randy Lubas, there will be 17 shows with over 200 comedians.
All of the shows this year will be at Ventura Harbor Comedy Club and The Green Room Lounge also at the same address, 1559 Spinnaker Dr. Ventura, CA 93001!
The Highlight of the Festival this year is The Ventura Comedy Competition, with over 100 comedians competing for a $4000 in prize money for the top 7 finalists.
The preliminary rounds are scheduled for the following dates.
August 8, 12, 15 and 22.
The Semi-Finals are on August 27,28, and 29 , during the week of the festival.
The Finals are on September 1 at 9:00.
I addition, there will be many theme shows including Clean Comedy, Funniest Females hosted by Katrina from Live 105.5., Latino All Stars, Rainbow Comedy, Black Friday hosted by Miss Alynette from Old School 104.7, The Bad Girls of Comedy, The Dirty Dozen hosted by Ron Jeremy, Evan Sayet with his Unredeemable Deplorable Show, and many more.
We have an All Access Ticket for every show in the Festival for just $49.99.


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My heart is so grateful for all that you've done.
I can't wait to spend my life with your son.
The perfect gift to give your future mother-in-law! This gorgeous sterling silver filigree necklace carries a sweet sentiment that your new bonus mom is sure to appreciate - and it can be worn all year long with this simple and elegant design.
A sterling silver filigree open teardrop charm comes on a sterling silver cable chain necklace. Choose between a 16", 18" or 20" length chain.
Comes in a jewelry box tied with ribbon. Sending this directly to someone? Be sure to include a note during the checkout process.

domain: design


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Announcement: Doors to the Insiders Club will open again soon! Get on the waitlist to be notified of our next enrollment period and to be eligible for special launch bonuses. For more info on all the perks of becoming a member, click here.
Look at these gorgeous, spring-infused arrangements created by stylist/Props & Set designer Saša Antic.
Beauty, joy, luxury, warmth and elegance – All at once!
Photos: Saša Antic


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Let us introduce Pamela Horton. Hailing from Wichita, Kansas comes the newest Playmate of the Month, Miss October. Pamela is both a Multimedia Artist as well as an avid Gamer. Enjoying such activities as Painting, Sculpting, Glass blowing and League of Legends, she certainly has a lot on her plate. Luckily for us, the beautiful Miss October took a few minutes out of her busy schedule for us to get to know her a little better.
UG: What is it like growing up in Kansas? Did you have a hard time breaking out and gaining media attention from there?
Pamela: I was actually born and raised in Los Angeles, CA. I moved out here when I was still in elementary school, and grew up in small towns around Wichita. It was never an aspiration of mine to get into modeling. When I was in high school I wanted to be an Art Therapist. I was brought into modeling at 18 by a very good photographer who introduced me to the do’s and don’t’s of the industry. I’ve been nude modeling since then, so I’ve always been very comfortable with nude photography. How I was found by playboy is a completely different story.
UG: Modeling for the biggest and most significant Adult Magazine is quite the honor, How did you get involved with Playboy?
Pamela: One of their submitting photographers in Chicago saw me and wanted to submit me for Cyber Girl. He sent in my pictures and his editor said she wanted me to come in for a Playmate test! That was the very beginning! 🙂
UG: Congratulations on receiving Playmate of the Month. What was your reaction when you heard you were Miss October 2012?
Pamela: My mom and I embraced each other and cried a little. My parents are so proud! I was driving on my way somewhere and I got the call and just drove with my mouth gaping open.
UG: Aside from gaining the title of Miss October, What kind of other benefits do you gain from such an honor?
Pamela: I got to have a 10-page pictorial in Playboy!! That is more than enough of a benefit!! On top of that, being asked to be on the cover? It’s so incredibly overwhelming!!
UG: We love our Video Games and grew up playing them, Were you a gamer as a child?
Pamela: My father put a SNES controller in my hand when I was five years old where I learned to play the first sequence in Legend of Zelda: A Link to the Past. (Before I could tie my own shoes!)
UG: You stated that you are “Obsessed with MMOs!”, What kind of MMOs do you like the most? How deep does this obsession go?
Pamela: I play either World of Warcraft and League of Legends at least once a day. How deep does it go?? I got Realm First Herbalist on the server Trollbane when Mists of Pandaria came out. 😉
UG: We understand you are quite the League of Legends player, Wanna tell us a little bit about your Character?
(Note: You got us there Pamela. 🙂 While we try to be a one-stop resource for all things gaming, unfortunately being “Unpaid” our time restrictions don’t allow us to play everything out there. Doesn’t stop us from trying. )
UG: I imagine you stay pretty busy with all of your projects and responsibilities, How much time are you able to free up for gaming?
Pamela: I make time! Hahaha. I travel a lot so I spend hotel stays and mansion stays on my laptop when I’m not working or visiting my friends. Gotta level up that Fire Mage!
UG: You made the statement “I love being known as every gamer guy’s dream”. What kind of response have you received from the gaming community?
Pamela: That quote was tailored to fit the page. It’s been widely misconstrued as arrogant or narcissistic. But let’s be honest. What man (in his right mind) has gone, “Oh my dream girl doesn’t like video games. She’s beyond that pish posh!” Any girl who plays Video Games is “Every gamer guy’s dream.” It’s a truth.
UG: So you like comic books? What kind do you read?
Pamela: I do! I enjoy any Marvel series. I’m not die-hard by any means, so I don’t know every story line forever. 😛
UG: Ever been approached by any “Creepy” fans?
Pamela: I have been fortunate enough to have only dealt with very nice fans. Although I did get asked once if I could send a fan my unwashed clothing…
UG: Do you have any upcoming projects you would like to talk about?
Thanks again Pam for giving us your time. We wish you the best of luck with your career and hope to see you grace the centerfolds more in the future.
If you are interested in checking out Pamela Horton’s Shoot, the October 2012 issue of Playboy is available now. You can also check out the following link
For more information on Pamela’s Art and Handicrafts, check out Etsy.com and the recently launched website,


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- Post-election taunts reported at Jackson schools (12/2/16)28
- Man killed by vehicle had been charged with domestic assault (11/30/16)
- Cape man gets 8 years for robbery, his first offense (12/7/16)5
- Man sentenced to 103 years for murder of Cape woman (12/6/16)3
- Burglary suspect apprehended inside Jackson garage (12/4/16)
- Poplar Bluff man accused of enticement, child porn in Scott County sting operation (12/4/16)
- Cape may allow residents to keep chickens; residents at meeting push for measure (12/6/16)33
- Men who pulled father, son from burning car near Naylor honored by highway patrol (12/1/16)
- Cape woman hopes son's death in Chattanooga will lead to better policing (11/30/16)11
- Lt. Gov. Kinder weighs in on Trump's win, his future plans (12/4/16)13
United Way goals
On the service end, the local United Way of Southeast Missouri has vowed to attack the root of the area's problems, not just the symptoms. That means it will focus on helping people at the family level, a more proactive approach than the United Way has taken in the past.
As for the fund-raising end, the United Way is setting its goals based on need, not on what it thinks can be raised. The United Way asked the area's community agencies what they thought it would take to provide the needed support to families. The needs analysis came first, then the United Way asked companies what they thought their contribution could be. The result was a $1.32 million goal, which is $200,000 more than last year's goal and $139,000 more than was raised last year.
Nancy Jernigan, United Way's executive director, says she's confident the goal can be reached. And she has good reason. The Cape Girardeau, Jackson and Scott City communities have shown an abundance of generosity over the years.
It is exciting to think how $1.32 million (or more) will be used to improve our communities. And we hope the new proactive approach will pay huge dividends in the future.

domain: sociology


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The Chief Minister, Mr. Bhupesh Baghel, met his officials at the office of ‘The Progress’ Trust, affiliated to Sri Aurobindo Yoga and Knowledge Foundation, at his residence office here today.
The officials informed the Chief Minister about the quality development efforts and works being done by the Trust in the field of higher education. He said that the Progress Global Awards 2020 will be organized by the institution on 7 November 2020 for outstanding contribution to educational services. He urged Chief Minister Mr. Bhupesh Baghel to be the Chief Guest in this program. Chief Minister Mr. Baghel appreciated the work being done by the Trust and expressed gratitude for the invitation for the program. On this occasion, Ms. Indrani Ghosh and Ms. Meenakshi Patel, trustees of The Progress Trust were present.

domain: news


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Back in 1977, the original Star Wars movie was a monumental hit, making over $775 million on a budget of just $11 million and for a time was the most successful film in the history of cinema. The franchise continues to grow in popularity today, but during the production of the first movie, George Lucas went through a living hell to get it made, with many moments where he didn’t know how it was going to be finished.
Lucas was speaking in a new interview for the Industrial Light and Magic visual effects company documentary miniseries, Light and Magic, on Disney+.
Those he’d hired to work on the visual effects shots were way behind schedule and he’d already filmed the movie in England.
The Star Wars creator admitted: “I was very frustrated editing without effects. ‘What did I get myself into? How am I ever going to get this done?’”
The film’s fourth editor Paul Hirsch shared: “Even I, who worked on the film, could barely follow the story. It was much rougher than rough cuts usually are.”
In the end, what became ILM did pull through and the rest was Star Wars history, but it proved no easy feat.
To find out how Lucas and his team pulled it off, check out Light and Magic, streaming now on Disney+.

domain: history


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When I first heard Ryan Adams’ Heartbreaker I was more impressed than I’d have been if I’d been familiar with the artists he was cribbing from. At that time, I didn’t know that many records by Bob Dylan, Van Morrison, Neil Young, Elton John, Alex Chilton, Steve Earle, Townes Van Zandt or Bruce Springsteen, or any of the other acts that Adams was stylistically in hock to. Nowadays, while I can still remember the emotional charge I used to get from My Winding Wheel, My Sweet Carolina and the sparse, charged Call Me on Your Way Back Home, most of the time when I listen to Heartbreaker I find the obviousness of his borrowings crass.
Which says at least as much about me as it does about him. No one said pop music had to be original. A lot of the time the joy of it is precisely its lack of originality, its willingness to repeat the formula exactly, to conform perfectly to expectation. But I had something invested in the idea of Adams as an original talent of the order of Dylan, Morrison or Young, which is absurd, but at 18 I knew know better. If I’d known twice as much then as I actually did, relatively speaking I’d still have known dick all.
So the magic faded somewhat, and when it did I was left with a record that was admirable for the way it replicated the sound and feel of certain rock-history glory moments, most notably producer Ethan Johns’ uncanny reproduction of the sound of Dylan’s mid-sixties work, most notably Blonde on Blonde. The devil is in the details where this sort of thing is concerned, and Johns has a record producer’s ear for detail; an ear schooled by his father, Glyn Johns – producer and engineer for the Beatles, the Stones, the Who and Led Zeppelin – from an early age
His drum tunings were key to pulling this off. Tune the drums correctly, then leave enough space in the performances for the resonances to really add to the overall sound. Then set the band up right in the room and allow the leakage of the drums into the guitar and vocal mics (yeah, live vocals – scared yet, you Pro Tools kids?) to dictate the overall sound. Johns was the drummer, the producer and the engineer for all this, so there is really is no overstating how important he was to the finished product (he also played bass, organ and Chamberlin – a precursor to the Mellotron).
Johns sits out almost three-quarters of the genuinely mournful-sounding Call Me on Your Way Back Home, finally coming in when Adams’ vocal drops out, allowing the sound of the room – captured in the guitar and vocal mics as well as in his drum mics – to supply a beautiful reverb, taking full advantage in his big, simple tom fills, which owe a lot stylistically to Levon Helm. Nowadays, when I think of Heartbreaker, I think of Johns’ drumming on the album: of the five-stroke intro to Come Pick Me Up; of the pattering brushed drum fills on Sweet Carolina; and of course of those authoritative and strangely uplifting thudding toms at the end of Call Me on Your Way Back Home.


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Oh, hey girl.
And hello to Jessica Alba as well. On Monday, the actress suffered a nip slip on the streets of New York City, accidentally revealing her sheer-bra-covered left boob as she adjusted her coat.
Later in the evening, Jessica's assets were all covered up at the 2013 Met Gala. Her Tory Burch perforated leather dress did have some cutouts on the chest and upper-stomach area, but no under boob or excessive cleavage made an appearance.
But unless you're Cash Warren, don't get your hopes up for another glimpse at Jessica's private areas. She told Britain's Scarlet magazine in 2010 she'll "never do a nude scene."
"I can act sexy and wear sexy clothes, but I can't go naked," she said. "I come from a very Catholic family so it wasn't seen as a good thing to flaunt yourself like that."
Sometimes modest is the hottestl

domain: celebrity


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Melissa did an amazing job! I had been to two other trainers and Melissa was the first one to solve our problems. She came in and quickly figured out what the issue was and solved it. Now I can walk my dog again without worrying about him pulling and barking at other dogs and cats! She is very knowledgable and was a pleausre to work with. I would recommend Melissa to anyone!
7222 Battenwood CtTampa, FL 33615
From Business: PETS~Pet Enrichment & Transport Solutions offers pawsitive pet services to the Tampa Bay community. Owner and Certified Dog Trainer, Brandi Burket, provides one-o…
7709 Gardner RdTampa, FL 33625
Melissa is a very responsible individual. She is very caring for our 2 dogs. They are so excited when she come to take them for walks !! She always leaves a note on her visit and the dog's activities. I have been using her services for over 2 years and she always does an excellent job !!! I would highly recommend her to anyone. Dennis Antinori

domain: pet


In the age when the lines between heroes and villains in Bollywood are blurred as actors are willing to experiment the other side of themselves in front of camera, this latest import from Mozambique - Vipinno has made a startling debut as a vicious killing machine in coal mafia saga – ‘Koyelaanchal’.
The upcoming episode of Encounter will feature actors Prashant Narayanan and Mishal Raheja. While Prashant will play dreaded gangster Shamsher Bhopali, Mishal will be seen as Nitin Kamte, a cop.
John Abraham’s next rolls in May, he plays a killing machine in it
A 12 feet long, 500 pound sharp clawed dinosaur – a killing machine dubbed as “chicken from hell” have been found by scientists to have roamed the earth along with Tyrannosaurus Rex around 66 million years ago.
Authorities said that first level checking of voting machines has been completed.
With the support of the Rotary Club of Salem International, an Automated External Defibrillator machine is being installed in the Station Master's room (Platform No.4 of) Salem Junction.
Nagpur District Badminton Association (NDBA) is inaugurating recently-acquired Shuttle Shooter machine at 6 pm on Friday at the NIT Recreation Centre Badminton Hall, Surendra Nagar. The machine will be inaugurated by Arun Lakhani.
EVM machines for the May 12 polls were checked for glitches at the Netaji Inddor Stadium in presence of political party representatives.
Bangalore Water Supply and Sewerage Board (BWSSB) will be deploying as many as 12 jetting machines to clear the sewage lines in MEI layout, Soladevanahalli, Bhahubalinagar areas of North-1 and Kethamarnahalli, Mahalaxmi Layout, Rajainagar-1,2, Nandini Layout-1 areas of North West-1 and A.E.C.S Layout, Hoodi, Bhuvaneshwaringar, areas of South East-1 Sub division jurisdictions on Saturday, February 22, 2014.
BWSSB will be deploying 12 jetting machines to clear the sewage lines in Frazer town, Machallibetta, Pillanna garden, DJ halli areas and Kengeri, Ideal home, BEML layout, RR nagar, areas of West-3 and HRBR, OMBR, HBR/Kalayana nagar areas on February 17.
As many as 12 jetting and two sucking machines of BWSSB will be deployed to clear the sewage lines in RT Nagar, Sanjaynagar, New BEL Road, Anandnagar, Ganganagar areas of North East-3 and MNK Park, Mount Joy, Nagendra Blk, Girinagar(Kathriguppe-2) areas of South West-3 and BTM Layout-1 & 2 areas of South-3 Sub division jurisdictions on February 8. For details call 9845444025.
V Kannan, chairman and managing director of Vijaya Bank inaugurated a coin vending machine at the bank's Dharmasthala branch.
An unidentified man broke into the unguarded ATM of Punjab National Bank's Vasai (east) branch. No cash was robbed.
Twelve Jetting and two sucking machines of BWSSB are being deployed to clear the sewage lines in AECS Layout, Hoodi, Bhuvaneshwarinagar areas of East-2 and Kengeri, Ideal Home, BEML Layout, RR nagar areas of West -3 areas of Sub division jurisdictions on December 21, 2013. For details public can call 9740984161 or 9740984165.
Manipal College of Dental Sciences, Mangalore will be the first dental college in India to have the comprehensively configured Cone Beam Computed Tomography (CBCT) Machine.
A 25-year-old Manaswi, an engineering graduate, killed husband Sathya Narayana, and then committed suicide by hanging at their residence in west Mysuru on Wednesday, said Sarasathipuram police
He said that during the dance programme Jaswinder's two sons Gurpreet Singh, Ajit Pal Singh, his son in law Manjit Singh and their friends were firing in the air. He said that his son Maninder urged them not to fire but they continued with it as they have over half dozen weapons. Jagir told the cops that when at around 9.30 PM he was about t oreturn after having food at the party
Deceased Maninder Snigh's father Jagir Singh told that his son had received the bullet in his chest and he was declared brought dead when they rushed him to a doctor. He told the police that he and his son had gone to the home of Jaswinder Singh in the village in the night on Monday to attend a Jago related function in which a dance party along with drinks was going on and some youths were indulging in firing in air.
Hoshiarpur A 21 years old youth was killed in village Kothe Jattan under Hariana police station when some youths were firing in the air during a marriage function to celebrate the occasion and the deceased was asking them not to stop. Among the 19 accused two are brothers of the girl for whose marriage function was organized in their home.


When Galileo pointed his homemade telescope at Jupiter and its moons more than 400 years ago, he fundamentally changed how humanity viewed its place in the cosmos. Since then, astronomers have learned to peer farther and farther into the reaches of the universe, first by building better telescopes, then by launching them into space. These efforts have resulted in the discovery of thousands of planets orbiting distant stars. Each tantalizing discovery has spurred a desire to know more about these exoplanets — but their incredible distance makes it hard to get a clearer view.
Scientists at NASA's Jet Propulsion Laboratory (JPL) have proposed a different approach: rather than launch a telescope into space, why not use the properties of gravity as a telescope?
Concept of a Solar-Gravity Lens
As Einstein pointed out, light is not immune to the effects of gravity, but will be redirected when transiting near sufficiently massive objects. So, light coming from far beyond the sun will bend if transiting near its periphery, eventually converging to a focal region — just as if it had passed through a lens. If a light-sensing instrument could be placed at the focal region, it could capture images of planets tens or hundreds of light years away with surface resolution down to the scale of a few kilometers.
A team at The Aerospace Corporation has been collaborating with JPL to explore the feasibility of such a solar-gravity lens. “The concept,” said Tom Heinsheimer of the Civil Systems Group Development Directorate, "is either completely crazy or the next big thing." The "crazy" aspect stems from the fact that the sun is not all that massive, as far as stars go, and exerts a relatively small influence on the light passing by. As a result, the focal region (or ring, actually) begins at about 550 astronomical units (AU) away—roughly the distance of three light-days. One AU is the average distance from the center of the Earth to the center of the sun, about 93 million miles or eight light-minutes.
Solar Gravity Lens Project Challenges
The obstacles to such a mission are significant but not insurmountable. The first hurdle is simply getting a detector to the desired location in a reasonable amount of time. Traversing 25–30 AU per year would get it there in about 20 years — even in the space industry, that is considered a long time — and that rate of travel has never been achieved. "Navigation is not a trivial matter," said Heinsheimer.
The detector will need to know its precise location with regards to a solar system that is constantly in motion. Once in position, it will continue to travel along the line of sight for many years, collecting reams of data that will have to be sent back to Earth. All of this will take power, which must be generated far from any star.
Addressing these challenges will require some innovative thinking and savvy systems architecting. Aerospace is analyzing various options and the most promising one at this point involves not a single large spacecraft but a fleet of small ones defining a cluster and a set of clusters in a string-of-pearls arrangement. A spacecraft under 10 kilograms could perhaps make use of a solar sail to achieve the needed velocity. For maximum efficiency, the sail could possibly be repurposed during the active mission phase—for example, to restructure antennas or expand the sensor plates.
Spacecraft Travel to Exoplanets
Navigation could make use of X-ray pulsars, which would essentially function as GPS beacons in deep space. Mission functions could be distributed among the spacecraft, so some units could be dedicated to navigation, shepherding the entire flock to their destination. Clusters of spacecraft could be launched on a regular schedule; that would lower costs and encourage participation from across the space community. It would also enable scientists to target multiple planetary systems within the same exo-solar system at the same time. As for system reliability spanning multiple decades, "that's not unreasonable," Heinsheimer said, noting, "once you get out there, nothing bad happens."
Moreover, the technologies involved in the distributed swarm — longevity, agility, autonomy, and self-learning — could revolutionize the space industry as a whole and significantly advance national security space objectives.
NASA Grant for Solar Gravity Lens Mission
Aerospace and JPL have been awarded a Phase 2 NASA Innovative Advanced Concepts grant to study the feasibility of the solar-gravity lens mission. JPL will focus on the science — for example, selecting candidate planets and processing the data — while Aerospace will tackle the technology — the architecture, operational concept, instrumentation, costs, schedule, and risks.
The results of such an endeavor are still many decades away. Still, if successful, the solar-gravity lens could conceivably detect geologic features, seasonal patterns, and maybe even signs of civilization on a distant world. If so, humanity may find its place in the cosmos fundamentally changed yet again.


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If you've never put together a 3D puzzle before, you might be wondering what they are. Jigsaw puzzles can be beautiful and challenging, of course, but 3D puzzles combine putting all those little pieces together with building a three-dimensional model or replica. There are plenty of fun 3D puzzles for kids that are a lost simpler to put together, but if you're an adult or have older kids who want a more difficult task with an awesome result, these are the 3D puzzles for you.
It doesn't matter whether you want to build something pretty and abstract; create a replica of a real, historic building; or build something mechanical that can actually move when you're done (yes, those exist!). Oh, and if you'd prefer to recreate the buildings from your favorite fantasy shows and movies, you've got options, too—Game of Thrones, anyone?
Put together an adorable little cafe and bookstore with this city-inspired 3D puzzle, made with 385 pieces.
Add an extra level of difficulty by not only building Big Ben out of 216 pieces, but also by adding a working clock to the iconic tower.
Once put together, this 121-piece 3D puzzle becomes a beautiful replica of Germany's Neuschwanstein Castle.
Game of Thrones fans will love building this 3D puzzle of Winterfell, but be warned—it's made up of 910 pieces, so it'll take you a while.
If you're more of a Harry Potter fan, try putting together this 450-piece 3D puzzle of Diagon Alley. And there are plenty more wizarding world puzzles where that came from.
Prefer building real destinations? This 120-piece puzzle will become a replica of London's Tower Bridge once it's complete.
Go for something more abstract with this colorful globe, which is made up of 540 pieces—each one a different shade.
For a serious challenge, build this wooden locomotive puzzle. It's made up of 349 laser-cut pieces, and once you've completed it, you can wind it up and it will actually move.
For another mechanical option that's a bit simpler, try putting together this 123-piece 3D treasure box that has a working lock to keep small items safe.
History buffs will love building this 113-piece 3D puzzle of the Titanic—and they can use it as decoration in their study or office afterwards, too.
Who needs to buy a ready-made globe when you can build one yourself? Sure, it might take 540 pieces to make it work, but the end result is pretty cool.


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Seven sports (Curling, Sledge Hockey, Basketball, Badminton, Athletics, Table Tennis and Swimming) over eight months (Nov-Jun) for 8-16 year olds, with a disability. Some upper body strength required.
Ryan Shay (Paralympian in training) will be hosting the program “the multi sport program will give participants the chance to exercise, meet others and most importantly shed light on para sport opportunities that’ll last a lifetime.”
Provincial Sport Organizations will have a leader for each sport presented. Held on Saturday mornings, it will be a safe and inclusive environment for lots of fun and activities.
A similiar camp was held in the summer and was a huge success for the participants, so now it is time to include more sports over a longer period.

domain: hobby


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Ur of the Chaldees
Ur is one of the most impressive ancient sites in Iraq. It was mentioned in the Bible as the birthplace of Abraham, and its earliest...
Arch of Ctesiphon
Little is left of the city of Ctesiphon, apart from the arch. The city was built in the 2nd century BC by the Parthian Persians. The...
Lonely Planet review
Babylon, perhaps the most famous of Iraq's ancient sites, was most prominent during the reign of Nebuchadnezzar II (605-563 BC). With its high walls and magnificent palaces and temples, it was regarded as one of the world's most beautiful cities. Now, all that remains of the ruins of Babylon is a huge and magnificent lion, eroded by time and the weather.

domain: geography


If you’re feeling more adventurous, you can download the song below and stream it to your iPod, iPad, or other device. But if you’re not, then this is the best way to keep track of your progress. We’ll be back in the moment with more music, songs, and videos.
For those who are just not listening to what the band’s playing, you can check out the new trailer. The trailer shows a picture of a shipwreck that looks like a waterfall, and the ship is not actually looking very deep, but it actually looks like a waterfall.
There are a lot of songs on this album, and they have a lot of good music written for the album (and other albums in the future). But there are also some songs that are really just for the sake of the band or the music. These songs are the stuff you just find yourself doing when you’re bored with the other music.
This was a fairly straight-forward first trailer that I’d seen (and have used) but I’m not sure whether I’m talking about the music, or just the audio effects, or just the song. My personal experience is that it’s pretty cool to have a trailer that is really just for the sake of the music, but it’s the music that gives you a sense of how things are going on now.
It also has a decent amount of animated shots, and I feel as if Im just hearing the song now, rather than actually seeing the video, or at least I hope so.
It’s been a long time since I’ve seen a song go from radio to video and into the internet. The video is probably the best part of the trailer, because it gives you a good enough idea of what happens next.
The best part is when the song goes from static to moving, to getting the song back to where it was before the video starts. Then the song pauses for the rest of the video, where the song jumps back to where it was before the track started. The song will then start again, and then pause for the rest of the video. I would think it would be impossible to get the song to stop and then continue, but its certainly possible, and more impressive than the trailer is.
Naanum Rowdy is a song that happens when you are distracted in your business or home, or when some of your other activities get you really out of sorts. The video is actually just a series of short clips from the song, and as you can see from the title, it actually starts out as a short. It then gets more and more interesting as the video continues, but then the song pauses at the end, to give you the chance to catch your breath.
The reason I am not here is because I’m not the biggest fan of the song, and I’m not the biggest fan of the trailer. I’m not the biggest fan of the trailer and I’m not the biggest fan of the game. But I know what you’re doing. It’s just that I know what you’re doing. So I’m not here because I’m not the biggest fan of the song.


Brighton based Cate Ferris is a “one-woman symphony of lush textures, electronic beats and soulful harmonies”, a singer-songwriter and multi-instrumental artist who has been captivating audiences across the UK & Europe with her solo project.
Her extensive and sometimes eccentric instrumentation is tinged by hard-hitting lyrics and structured around “sublime and beautifully crafted songs” (Jeff Hemmings, Brighton Noise). Tipped by David Rodigan in the Independent as one of the best up-and-coming artists, her work has featured on BBC1 Xtra and her voice on prime-time television.
Ferris has worked and collaborated with great musicians from a wide range of genres – Nick Menasseh, Martha Tilston, Alex Banks, Nordic Giants. She was lead vocalist and co-writer for Dizraeli & The Small Gods, an eclectic 8 piece hip-hop band, whose album ‘Moving In The Dark’ was shortlisted for the 2014 Songlines Music Awards and she has performed on the West Holts Stage (Glasto), the Royal Festival Hall, Latitude Festival, main staging Larmer Tree and headling Purbeck Folk Festival to name but a few.
Immersed in the rich tapestry of the Brighton Music Scene, Ferris has created her bold debut album. Weaving the colorful threads of her music world through a network of talented musician contributors; Ferris has produced a refreshing and inventive body of work. Fusing melismatic vocal hooks with lush synth lines against a backdrop of beats created from broken gramophones and slammed doors, ‘Gyroscope’, co-produced with Rob Flynn (Oslo Parks) sees Ferris steps out from behind her loop stations to flex her ample production muscles and see her tackling some of life’s bigger questions more fearlessly than ever before.
SOURCE: Official Bio
RT @_BeautyInChaos @jammerzine / @JammerDirect Week In Indie “Afterlife” segment featuring @tishciravolo 🎥 pic.twitter.com/0ZN7…
About 2 days ago from Jammerzine's Twitter via Twitter Web App
RT @winachitribe WINACHI @jammerzine REVIEW ⭐⭐⭐⭐⭐INTOXICATED E.P feat RAFAEL ARAGON"WINACHI construct that score for your next memory with passion, perversion, and everything in between"PRE-ORDER // RELEASED FRIDAY -winachi.bandcamp.com 👈@JammerDirect jammerzine.com/winac…
RT @bentleybrowning @jammerzine Thanks for the airplay today! #music pic.twitter.com/7rqD…
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RT @_BeautyInChaos many thanks to Ryan Martin and @JammerDirect /@jammerzine for including our new Beauty In Chaos “Afterlife” video in their fantastic This Week In Indie Show 🍷🎥🍷jammerzine.com/jamme…
RT @EclipseRecords WATCH: @genusordinisdei sing about spike-carrying viral soldiers assaulting humanity in their new "The Entropic Queen" music video via @jammerzine \m/ @PressThis_PR jammerzine.com/genus…


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5th August 2017
The fourth and final part of Saturday's Breckland excursion. When the rain began to pour down we had thought that the Brandon Artemisia visit would be the last site before we headed home, however as the sun started to come out we decided to check out a couple of woodland rides near Santon Downham to look for more rare plants and bees.
We went to an area where I had seen Broad-leaved Helleborines in the past, and they were still present, with over 40 flowering spikes seen. The species that I had particularly hoped to see were the Knawels, and through careful searching I manged to find one small plant of the commoner of the two, Annual Knawel, growing at the edge of a path.
We carried on along the ride, seeing a range of plants including Bur Medick, Bifid Hemp-nettle, and Tower Mustard (the latter a new one for me). A shower passed over and there were few insects about, but I did find an adult Tortoise Shieldbug to go with the late instar one found at Brandon.
We then tried another ride and an area where Ian had seen Perennial Knawel a few years ago. We didn't find it, with three Knawel clumps all turning out to be Annual Knawel, albeit nicer ones than my straggly plant. An Adonis Ladybird and a Hummingbird Hawkmoth completed a very successful days wildlife watching.


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The new year is upon us, and 2014 is the perfect time to revisit some of the most popular jewelry trends of the last year. Here are three of our favorites that don’t show any signs of stopping. We’re confident that they’ll keep on trending right through the year.
Chain necklaces made of silver. These were incredibly popular this year – and we don’t mean just the pre made chains either. Industrial links, hammered pieces and delicate, airy chains. It seems like everything is going when it comes to chains. I really like this trend for its versatility. Silver chain looks just as appropriate with a t-shirt as it does with that special little black outfit.
Strong statement pieces, oversized rings, dramatic earrings and sparkly, flashy pieces were all the rage in 2013. So far this year the trend continues! Maybe during shaky times strong pieces instill confidence in people? Whatever the reason, I am very glad that big jewelry has made a comeback. Wear those big pieces,huge earrings and outrageous cuff bracelets with pride!
Mixed metal anything! I. Love. Mixed. Metal Jewelry!! Silver or gold, copper or brass pieces all mixed look great on everyone, everywhere, all the time.
Think I missed one? Tell us about a jewelry trend that you think should have made this shortlist in the comments below. . ,


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Turned up! Christina Milian wears plunging white dress as she attends bash honoring Oscar nominees
Christina Milian showed off her figure in a low-cut white dress as she attended The Hollywood Reporter's Nominees Night.
The singer and actress looked stylish as she attended the bash, which honored this year's Oscar nominees, at Spago restaurant in Beverly Hills on Monday.
The Grandfathered star was joined by Academy Award Best Actress nominees Alicia Vikander and Jennifer Jason Leigh.
Turned up: Actress and singer Christina Milian wore a low-cut white dress as she attended The Hollywood Reporter's Nominees Night in Beverly Hills on Monday
The Christina Milian Turned Up star looked relaxed as she struck a pose at the Hollywood bash.
In addition to a low-cut neckline, the 34-year-old's tight white dress featured long sleeves and a flirty flared skirt.
The actress flashed a large silver ring and added matching drop earrings.
Stylish: The 34-year-old added a feathered clutch and light green heels
She also held a white feathered clutch and wore sea foam green heels.
Christina, who recently signed on to play Magenta in Fox's updated TV movie The Rocky Horror Picture Show, wore her dark hair in soft curls around her face.
She added dramatic eye makeup and pink lipstick, and showed off a light pink manicure.
Bright white: The Grandfathered actress wore her dark hair in soft curls
Also attending The Hollywood Reporter Nominees Night was actress Alicia Vikander.
The rising Swedish star is nominated for Best Actress in a Supporting Role for transgender drama The Danish Girl, which also stars British actor Eddie Redmayne.
The 27-year-old wore a strapless black corset over flowing black pants. She wore her brunette hair brushed to the side in soft waves and added a delicate silver choker.
Chic: Actress Alicia Vikander wore a black corset over flowing black pants as she attended the Nominees dinner
Rising star: The Swedish actress is nominated for an Academy Award for Best Supporting Actress for her role in The Danish Girl
Also attending Beverly Hills bash was actress Jennifer Jason Leigh, who is also nominated for Best Supporting Actress for her role in Quentin Tarantino's The Hateful Eight.
The 54-year-old wore a black gown with a geometric pattern and frilled sleeves, and carried a black clutch.
She wore her blonde hair pinned back, and accessorized with matching necklace and bracelet.
Also attending the bash was DailyMail.com's US Editor-at-large Piers Morgan, who wore a slim navy suit and red tie.
Classic black: Actress Jennifer Jason Leigh's dress featured frilled shoulders and a sheer patterned skirt
Dapper: DailyMail.com U.S. Editor-at-large Piers Morgan also attended the Hollywood bash
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The Philippines really blew my mind. In the middle and west parts I have seen the most beautiful beaches I have ever seen and in the north I visited the hill areas with ancient rice fields higher and steeper than I had imagined.
It took me some time to find a moment to start writing the blogs. I’ll divide it up in two parts, the one with company and the one without.
The reason I was visiting the Philippines was the day 24-02-2017. This day my best friend and her now husband would say their I do’s at their beach wedding on the White Beach in Boracay. Before this I hadn’t really considered going to the Philippines but I’m really happy I got to go for this special occasion. The Philippines has a lot to offer and I have only been able to see three destinations.
I was also looking forward to this part of the trip for the company. Traveling alone has been great for good reasons, I only get to deal with my opinion, I can decide my own pace, full and active days, you meet much more people, flexibility, etc. But it can also be lonely and the next 10 days would be full on socializing with my friends, who I have known for years. Always someone around you, no forced conversations about who you are and where you are traveling, just catching up and making new memories.
It took me 14 hours to get form HCMC to Boracay with two flights, some waiting time in between, one crazy taxi ride, a ferry and a tricycle. And then after settling in W-hostel I met Jaytu, Tommy and some other family members for a cocktail on the beach. Crazy moment realizing you’re just sitting there with people you know and talking Dutch non-stop. I think I got used to it in the next 5 minutes but it happened again and again when the other guests arrive over the next few days.
On my first day in Boracay it was raining in the morning, but the afternoon was sunny enough to get a sunburn. We went to Ilig Iligan beach. It is a nicely quiet beach where we enjoyed some fresh coconuts and there was a lot of catching up to do. In the evening we went to the pre-wedding party. Almost all the guests had arrived and it was the perfect setting to have a little party. The theme was carnival and that led to two polonaises (both included Filipinos from the party next to ours, they were also filming the whole thing with amazement. I wouldn’t be surprised if it was up on YouTube somewhere). We had good food, good drinks (a few too many maybe) and a lot of fun.
That night at some point I heard a loud bang and Erik was lying on the floor. He said he was alright and went to the bathroom. It wasn’t until the morning that I realized he actually fell from the upper bed which was really high and onto the concrete floor. We had such a laugh about it and it still cracks me up now. He only had little bruising, could have been much worse off.
The next day we went to Puka beach to chill until the rain came in the afternoon. There had been a lot of rain actually which no one expected. So everyone had their fingers crossed for tomorrow.
Then the big day came, it was dry and there were some clouds but it looked good! All the ladies went to Jaytu her suite for hair and makeup and I had a true model experience when two people where styling me at once. The wedding was on the beach and the setup was amazing. A beautiful ceremony where there was no dry eye amongst the guests, a beautiful bride and groom, a romantic dinner setting, a sandcastle, live music, fire dancers, an opening dance..everything to make the perfect wedding. It was extra special for me as I was one of the two legal witnesses to sign the marriage license. I don’t have many pictures of the day as there was a photographers team present. But just to get an impression of the dinner setting see below.
The day after the wedding was very relaxed, it would be the last day with the entire group together (Gudo and Colette parting ways). We spend some time swimming in the pool at the resort where the wedding was held the night before. The sunset from this side of the island is very beautiful so we stayed to see it before walking back to our part of the island.
The next day seven of us travelled to Palawan. Palawan has been named earth’s most beautiful island. So when you already go the Philippines, it is a must visit. The island is not that far from Boracay if there would have been a direct flight, but there wasn’t. All in all it takes up the entire day to get there. First a van to the ferry, then the ferry, then the ride to the airport, the first flight, waiting time and the second flight. After some 12 hours of traveling we reached Puerto Princesa, Palawan.
Puerto Princesa is in the middle of this thin and long shaped island. El Nido, where the magic happens, is in the north end. This journey is another 6 hours by van (you can go straight there from Manila as well if you have enough money for the ticket). I was able to combine this trip with a visit to the underground river. Supposedly one of the new world wonders. It was a day for patience because there was a lot of waiting. But in that time I was able to do a cool zip line along the coast. The river tour itself takes you and 9 others in a small boat, peddled by hand, 2 km into the mountain where you can witness the spectacle of the stalactites and stalagmites around you. The water in the beginning is light blue and there are some really nice shapes, open areas and thousands of bats. After this I still had to travel five hours to El Nido, with a much to crowded van. I did meet some fun people and could check in to the best hostel I’ve stayed in during my travels so far: Spin designer hostel (recommended!!).
The next four days were 100% beaches, island hopping, coconuts, white sand between the toes, waves, beautiful sunsets and relaxing. The group here was nine people (Chloë, Justin, Erik, Jeroen, Angelica, Remi, Jaytu & Tommy one day later and myself). We first went with a couple of scooters to Nacpan beach. A long stretched beach with very high waves (so high it became uncomfortable when you got caught by one). And Twin beach for the sunset.
The next day we explored Las Cabañas beach. Then we did a tour day with our own private boat. This was the best day. We saw a combination of the available tours A and C, a total of 8 highlights. Secrets lagoons, hidden beaches, snorkeling and the best lunch I’ve had in the Philippines prepared right there on the boat. The beauty of the locations we visit is intense, I dare to stay that these escapes will be super crowded in 5-10 years. But luckily for us we are there now. The weather is great and let the pictures do the talking.
The last day on El Nido we rented kayaks to cross over to another island where we could find some almost private beaches. Again the sand is white, the water is light blue. We didn’t really prepare any lunch so we asked a local guide to get some coconuts fresh from the tree above us, drinking it without a straw. This day had these moments where you have to pinch and check if you are not dreaming. Only thing was not eating anything other than some chips but having to workout in the kayak in the burning sun to get back to the shore was heavy. I wanted to have one last dinner with my friends before saying goodbye but everything went downhill from here. Within a couple of hours I was having a fever and stomach problems. And that’s kind of where this part of the trip ends :).
Take nothing but pictures, leave nothing but footprints, kill nothing but time, keep nothing but memories.

domain: travel


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In an essay about myself, it's essential to avoid clichéd introductions like "My name is..." to engage your readers more effectively. Here are some personalized alternatives to make your essay stand out:
Capture Your Essence: Start with a brief, impactful statement that encapsulates your essence. For example, "I am a dedicated environmental enthusiast, committed to preserving the planet for future generations."
Anecdotal Opener: Begin with a personal anecdote that reflects your character. "One memorable day, while volunteering at a local animal shelter, I realized my deep passion for animal welfare."
Philosophical Approach: You can take a more philosophical approach. "As I navigate the intricate web of life, I find solace in exploring the profound mysteries of existence."
Defining Moment: Describe a pivotal moment in your life. "When I overcame a challenging obstacle during my travels in Southeast Asia, I discovered the power of resilience."
Metaphorical Expression: Use a metaphor to represent your identity. "Like a prism, my life reflects a spectrum of experiences, from the vibrant colors of art to the analytical clarity of science."
Professional Introduction: If your essay pertains to your professional experience, you might want to begin with your career focus. "With a decade of experience in marketing strategy, I continually seek innovative ways to connect with audiences."
Quotation or Proverb: Start with a relevant quote or proverb that encapsulates your values. "As Mahatma Gandhi once said, 'You must be the change you wish to see in the world,' and this philosophy guides my life."
Personal Mission Statement: Craft a concise mission statement that defines your purpose. "My mission is to empower marginalized communities through education and advocacy."
Hypothetical Scenario: Describe a scenario that illustrates your aspirations. "Imagine a world where technology and sustainability coexist harmoniously. This is the world I aim to create through my work in renewable energy."
Rhetorical Question: Pose a thought-provoking question. "What drives me to wake up each morning? It's the pursuit of knowledge and the desire to make a difference."
In conclusion, ditching the mundane "My name is..." for a more creative and personalized introduction can set the tone for an engaging essay about yourself. Whether through anecdotes, philosophy, defining moments, or professional focus, you have numerous options to captivate your readers from the outset.
On topic: Improve your writing skills on the current issue, with the help of a writing services website; further explore the current issue, using the writing service site. Visit Write Paper for Me to enhance your writing skills and discover more tips on crafting compelling essays.

domain: literature


text:
Transport and Maritime
The Transport and Maritime sectors pose challenges to the modern HMI, often operating under extreme conditions, wide temperatures, and prone to saltwater ingress, StarVision has provided some novel engineering solutions worldwide, to big names in the Automotive and Maritime Industries. Whether you are manufacturing an Aftermarket Automotive Device, Marine Control Panel, Rugged HMI, Vehicle Weight Scale or GPS Navigation Tool, StarVision has the solution to your problem.
StarVison has developed IP rated enclosures for a variety of rugged Transport applications. Whether a fully fledged IP67 certified design or simply a NEMA 2 standard using 3M Die Cut Double Sided Adhesive Gasket, our consultative design approach leverages engineering experience globally, gained across numerous projects, past and present.
Direct Sunlight Operation
StarVision is aware of the challenges posed by direct sunlight, not only due to the visibility of a display, but owing to UV damage of polarisers and bonding material over time. Component selection, and superior engineering negate the risks and impact. we provide ultra high brightness backlighting design , Starbond® Optical Bonding, and IPS mother glass, to create a combination of features designed to enhance the viewability of an HMI.
Rugged Housing Design
Transport and Maritime applications often require rugged enclosures and metal work, bezels and gasket design. StarVision China’s in house Monitor development and production team have created compelling examples of rugged housing, to protect displays and touch sensors from harsh vibration and shock.


Technicality Leads to Unusual Details of Giants Rookie Andrew Susac's MLB DebutSeptember 2, 2014
Every Major League Baseball player will remember his big league debut or his first career hit, but in the case of San Francisco Giants rookie Andrew Susac, it's not so clear-cut.
On July 26, the Giants called Susac up to the major leagues for the first time. However, the record books will show that he made his major league debut on May 22.
How is that possible?
On May 22, the game between the Giants and the Colorado Rockies was suspended with the score tied 2-2 in the bottom of the sixth inning. The game was resumed Monday, with Susac now a member of the team.
The catcher entered the game when it resumed. Although Susac had already appeared in 17 games, this appearance will technically go down as his major league debut.
To make things a bit more complicated, he singled in the eighth inning of the suspended game this week.
On July 30, the rookie had notched what appeared to be his first big league hit.
Which should Susac remember as his first career hit?
It's an unusual—but awesome—twist to Susac's career. It may not be the easiest for fans to follow, but the rookie can decide for himself how he remembers his MLB debut and his first hit.
There's no confusion as to what this game will count as for the Giants. They won the game 4-2, so they can just add a game to the win column.
[MLB.com, h/t SB Nation and Big League Stew]


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text:
Regional councils will soon start receiving funds for urgent pothole repairs, under the New South Wales Government’s $50 million Fixing Local Roads Pothole Repair Round.
Minister for Regional Transport and Roads, Sam Farraway, said all 94 regional councils that applied for funding have been approved for grants.
“From December, councils across regional NSW will receive their share of $50 million to repair pothole-ravaged local and regional roads,” he said.
“That’s money going straight into the bank accounts of councils like MidCoast, Tamworth and Dubbo to help them cover the extra costs and workload pressures following this year’s unprecedented rain and storms.
“These grants are a rapid injection of cash to help councils get on with the job of repairing potholes to get us through the wet summer ahead.”
According to Farraway, this additional support will help councils to repair their most damaged roads, thus improving safety and reducing wear and tear on vehicles.
“The NSW Government is backing our councils with this dedicated pothole repair funding which is the first of its kind in NSW,” he said.
“This is on top of the ongoing investment in a stronger road network through Fixing Local Roads, Fixing Country Roads and Fixing Country Bridges.”
MidCoast Council Mayor, Claire Pontin, welcomed the funding after the region had experienced several floods and severe weather conditions this year.
“We have more than 3600 kilometres of local and regional roads to manage across the MidCoast Council area that have been badly damaged,” she said.
“Every dollar counts towards ensuring they are repaired as quickly as possible.”