Ditch the workout, join the party!
Published 02 May 2012
Continuing our New Year New You series of health and fitness articles on Circle Extra, Zumba instructor Shelley Hall tells us how she too got hooked into the fitness craze everyone is talking about!
“I was already a salsa dance instructor when I found out about Zumba. I already loved the Latin dance and music elements that Zumba offered, and really enjoyed high-energy aerobics classes, so mixing both together sounded like brilliant class idea. A few friends had heard of it and were teaching and/or participating in classes already, I so decided to join them. After the first class I really wanted to teach it! “I learned to be a Zumba Instructor in November 2010. By then it had already taken the UK by storm, but I enjoyed it so much, I wanted to part of this new phenomenon. “There are Zumba courses you can take all over the world to become a Zumba Instructor, so I booked onto the first course available. I was already a fitness instructor by this point, and already teaching exercise and dance classes, so Zumba was the next natural step - mixing exercise and dance together in a group environment. “Zumba is popular because it's fun. It's different. Not many people experience Latin music or dance moves in their lives, so to come into contact with it as an exercise class is something fresh for them to try. “Some of the massive health benefits to be gained from Zumba include lower resting heart rate, improved cardiovascular fitness, faster recovery, stronger muscles, more energy, and faster metabolism. [caption id="attachment_1375" align="aligncenter" width="461" caption="Shelley Hall (bottom centre) with one of her Zumba classes"][/caption] “I love everything about Zumba - the music, the dance moves, the energy, the fun and the atmosphere – everything! It's especially great when you see everyone in the class enjoying themselves too - that's the biggest buzz. “Zumba is one of the best workouts you can do, without it feeling like a workout. It's fun, you can relax, have a giggle, it's social and it's unlike any other exercise class there's been before. “I always make slight changes to each class, like adding new tracks, choreography, offering free raffles, ‘bring a friend for free’ offers, loyalty cards and free class tickets. Every now and then we'll do a Zumba party session, where we learn popular dance party tracks for a bit of fun. There are also various Zumba weekends or holidays that participants can go on. “I'd like to start offering big Zumba events for my Zumba loving class! I'm always trying to keep everything fresh and exciting. Exercise should never get boring. It can’t with Zumba, as there's always something new to look forward to -from the clothes on the website, to charity fundraiser events, party weekends, Zumba holidays, and new people all the time! “As an instructor and personal trainer I'm always learning new things, or trying new courses, so am able to offer things other than just Zumba to my participants - even down to nutritional advice and home workouts. Aqua Zumba is also proving popular, so watch out, there may be some more Zumba appearing in a venue near you soon!Shelley Hall’s Zumba classes are on at the Colchester Institute Sports Hall every Tuesday 6.30pm – 7.30pm. To find out more call Shelley on 07912 291953 or join the Shellz Zumba Colchester Facebook group.


Hardened By Pipeline Steel
This year the pipeline transport of Kazakhstan celebrates 80 years. This is a significant and important event for the whole country, because the development of the oil transportation system is an essential component of the overall progress of the domestic oil and gas industry.
History of Kazakhstan’s oil transport system is a glorious and decent way of development, which was accomplished to to a huge role, played by the people whose names were included in the records of the country’s oil. One of the outstanding veterans of the oil industry is Ferdinat Mamonov, participant and head of many large petroleum projects, with no analogues in the world. He is one of those who gave the establishment and development of domestic oil transportation system for nearly 50 years. His name entered the history of the oil and gas industry and he joined such legendary figures as Anatoly Kashirsky, Ivan Casper, Taras Kassymov and others.
Ferdinat Abrakhimovich says about himself: “My way to the oil&gas industry was a foregone conclusion.” His grandfather and father were the drivers and they have worked all life at the fielf, the younger sister gave her whole working life to the oil industry and she was retired after working in Embaneft. Ferdinat Mamonov started his career in the oil industry as a mechanic and machine operator of a process pump at the construction of Uzen-Atyrau-Samara pipeline. It was the end of the 60 ‘s, the time of discovering the major fields of Kazakhstan-Uzen, Karazhanbas, Buzachi, with huge oil reserves. But it is not enough to produce the oil extract, it is equally important to transport it. Timely and responsive oil transport system ensures the development of the field.
-Then we spent day and night at the construction site, sometimes, we had the weeks without going to the city, we practically lived at the construction site, we were dirty, tired, hungry, - says Ferdinat Abdrakhimovich. -But we thought only of how to run a pipeline in time. I was lucky with the mentor: the first chief of OPS was Venedict M. Schelochilin, he taught me to love my work and to work the way I would never ashamed of the results.
The was a respected oilman, great professional, and very kind person. I well remember his paternal words addressed to us, young engineers. He said: “Be patient, folks. The builders will be gone and we will live well afterwards. The flowers will be planed around. All will be beautiful in our work place.” His words, of course, helped us to survive the domestic difficulties, but we didn’t managed to plant the flowers. Then I realized: nothing can be delayed for later term-it is required to live fully and well right now.
The first batch of Mangyshlak oil was sent to Guryev refinery on July 10, 1965. The first tanker Jabrayil of Caspian shipping company was loaded and sent for processing to Volgograd oil refinery on October 10, 1966. In order to send the oil from pumping station “Shevchenko” by the rail and sea transport from the port of Aktau, where the terminal was built, we used the pipeline Uzen-Zhetybai-Shevchenko (now -Aktau), with 529 mm in diameter.
Since the oil contained the paraffin and transport was difficult, it became a solid mass under normal temperatures-the heating furnaces were built at Uzen-Shevchenko part of the pipeline. But their capacity was not enough. In the mid 1960 ‘s, the Government of the Soviet Union decided to build a hot-oil pipeline Uzen-Kuibyshev with larger diameter of 1020 mm.
The first phase was the construction of Uzen-Kulsary-Guryev line and the second -Guryev-Samara and then connecting them to Druzhba pipeline . Mangyshlak oil with high paraffin content created certain difficulties for its transport, filling and storage. Therefore, the oil pumping stations (OPS) were built together with the heating furnaces and storage tanks were equipped with heaters. In addition, the separate heating units were provided in-between the OPS. The total length of pipeline Uzen-Guriev-Kuibyshev was 1380 km, with 9 pumping stations, 15 heatings units, located along its total length.
The first stage of Uzen -Guriev pipeline was put into operation in August, 1969. Then approaching the source of oil supply, we ran the intermediate heating points, “66 km”, “Sai-Utes”, “Beineu”, “Opornaya”, “Kulsary”, “601 km”, “OPS-663 km” pumping stations. And, finally,the oil pumping station “Guriev”, one of the largest on the pipeline (now the OPC named after T.Kassymov). In April 1971, the oil came to Samara. This pipeline at one time was called “hot river” of the USSR.
- Starting up such a complex, unique oil pipeline, which had no analogues in the world, was a historic event,- continues Ferdinat Mamonov.-The ceremony of commissioning was attented by the First Secretary of the Regional Party Committee M. Issenov, Deputy Chairman of the Soviet Oil Industry and the Head of Acceptance Commission Sh.Dongoryan, Chairman of the Working Committee Nuribek N.Shmanov (he then worked as the Head of the Caspian -Orsk Oil Pipeline Department, the only in Kazakhstan). Head of pumping station Uzen was Frangiz Mulyukov, a young specialist who later became Chief Engineer of Yuzhnefteprovod.
There was no ceremony then, as I remember. Everyone was nervous and worried. Operators with torches incited the nozzles, manually opening and closing the bolts of large diameters. Another difficulty was the following: we used Mangyshlak oil for heating the nozzles (there was no gasification yet), that hardened in the fuel lines, even on the way to the nozzles.
There were torches to heat the oil, providing access to the nozzles of heating furnaces. And when all goes well, joy bounds. At the initial stage of the operation the situation was very difficult. People had no experience of work at a unique pipeline. There were the complications, because all was mastered for the first time. Sometimes, all the flow hardened and then all the people spent day and night in the heated containers or booths, ensuring a return to a reliable work pace. The remoteness of the OPS from each other (90-100 km), off-road, lack of telephone communications, dining room, dormitories- the conditions were not simply the Spartan, they were truly heroic.
Naturally, we were all excited and forgot the hardship,-continues Ferdinat Abdrahimovich. -I think that the important role was played by the friendship, mutual understanding at work. During the starting-up and adjustment works, lot of petroleum specialists from Tatarstan, Bashkiria, Azerbaijan were involved at the pipeline. Although they have never seen such a pipeline before, jointly we had the rotations, training and we were acquiring the job skills.
The efforts of people were not in vain. In the last days of August 1969, the first train was loaded with oil from the oil tank farm at Guriev loading station for transporting to Volgograd oil refinery. This date is the date of birth of one of the largest stations-Guriev oil trans-shipment statiom (now the OPC named after T. Kassymov). His first chief was Venidict Mikhailovich Schelochilin.
-I consider myself as lucky one because on my way I met the people, one better another, both as the professionals, mentors and leaders,- said the veteran. -Anatoliy Ivanovich Kashirsky, Viktor Pavlovich Balduev... People are the decisive factor. In those years there were almost no pipeline specialists. The main role was played by managers and specialists of the then-operating oil pipeline Caspian Sea-Orsk- Nuribek Shmanov, Ivan Casper, Mavey Rubalskiy, Vasily Shvabauer, Gennady Chebotarev, Victor Sutyagin, Anatoly Vikhrev, Maria Nurgalieva, A.A. Koszhanov, Lev Zhuravlev, Valentina Kovalyova, Tamara Tryakina, Alexandra, Chepaskina, Valentina Grigoryeva, Lydia Vashurina, Tamara Rotnova and others.
Professionals from Emba oil fields were sent to the oil pipeline. Among them were the specialists such as A.Dergachev, Baikadam Dzhumagaliev, Konstantin Gagaev, V.Ulchenkov, M. Popivchak, Evenrid Donskov, O. Mekebaev, Zenon Abdrakhmanov. The graduates of the Politechnical university, Moscow’s oil institutions, alumni of Ufa institutes were sent here for work. Subsequently, Vladimir Bibyaev, Michail Akutin, Baykadam Dzhumagaliev, Shtatbay Tumysh, Nuribek Shmanov, Sabit Rziev, Serik Murinov, S.Aldashev, Assylbek Beshimov, Melyat Karabalin and many others achieved the positions of major specialists and managers. They are all sons of oilmen of Emba, who occupied and occupy the leading positions, professional oil pipeline specialists.
Ferdinat Mamonov was a member of the epoch-making constructions-Kenkiyak-Orsk pipeline, Tengiz-Astrakhan-Grozny (presenly- CTC), water pipeline Astrakhan-Mangyshlak, which today provides with drinking water the city of Kulsary, Zhanaozen, and other localities in arid Atyrau and Mangistau regions. For a long time Ferdinat Abdrahinovich was the First deputy General Director of kaztransoil JSC, managing the largest production unit – the Western branch. In the early 2000s, Kumkol-Kenkiyak-Atyrau pipeline was constructed under the leadership of Mr. Kabyldin who was directly in charge of strategic development of the pipeline transport at that time. The pipeline connected the west and the east of the country allowing the Western Kazakhstan oil to enter the new outlets.
-I thank my lucky stars that I worked for KazTransOil for a long time,-says Ferdinat Abdrakhimovich. I am proud that the company worked sustainably even in crisis situations, and there were quite a number of them. Turning point for the fate of many oil workers were the 1950-s, when the development of unknown world’s richest accumulations of the Mangyshlak peninsula was started. Work was unbearably hard due to severe weather conditions, where the summer heat of Mangistau is +50 degrees in the shade, complicated by the absence of settlements, roads and drinking water.
Production had to be started from scratch: in addition to the lack of basic living conditions, we lacked the expertise, technology, equipment, transportation. Despite all the difficulties, the oilmen have gone to the end and they were rewarded. Yes, during the difficult 90-ies we sometimes had not been paid, sometimes we received the food or household appliances instead of the salary. But nobody was leaving, all the people performed their duties.
He spent his entire life working on pipeline transport. Friends consider him as a workaholic. He shared that even on holiday his thoughts were all about the work. Production achievements of “KazTransOil” he always considered as the achievement of all staff. It argues that the main merit of all of what he has achieved in life, belongs to the beloved wife.
-Now, looking back at the past, I understand, that, probably, the biggest credit for what I’ve achieved in life is due to my wife, Tatyana Alekseevna, -sums up what the veteran. -She is my friend and adviser, a caring wife and mother. In general, it is hard to be a wife of the pipeline specialist. I am constantly on the move, constantly on the road.
And all the household duties and raising children falls on the fragile shoulders of women. And when I work on the pipeline in my younger years, I’m amazed, how our wives could live in these difficult conditions. The pipeline workers always return deep in oil. At that time, there were not any uniforms, and the wife had to hand-wash my daily work clothes, which often had to be soaked in gasoline, and only then, it was possible to wash it.
Of course, now the good things are more valued and the difficulties are erased from the memory. After all the time was very special and everyone was enthusiastic, especially, the young ones. We truly loved our motherland and we supported the difficulties, both at home and at the work place. We were full of energy and we had a confidence that all the hardship is temporary and sooner or later we shall overcome it. Then there was no such word as corporate spirit. But this is how I would describe our attitude to our work-we’re all for a common cause, and it seemed natural. Themotherlandcalledusandwewentahead.
Published the full text of the article


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Wyden and Merkley Applaud Senate Confirmation of Federal District Court Judge Michael McShane
Portland, OR – Oregon Senators Ron Wyden and Jeff Merkley today applauded the Senate’s confirmation of Multnomah County Circuit Court Judge Michael McShane to serve as a U.S. District Court Judge in Eugene.
“Over the years Oregon has been blessed with a long line of distinguished judges,” Wyden said. “Judge McShane will be a tremendous asset to the court and he will certainly add to that tradition. He’s got a heart for people, a head for the law and a high-minded sense of justice.”
“Over his career, Michael McShane has demonstrated a tremendous commitment to the law, to public service, and to the state of Oregon,” said Merkley. “He will be a terrific addition to the federal bench.”
McShane was confirmed by the Senate by voice vote and will serve as a replacement for U.S. District Court Judge Michael Hogan, who has taken senior status.

domain: news


Sultry Songstress Tara Priya puts the S in Soul in this gorgeous video. If you're looking for a little Retro Love, Tara's got you covered. Visit Tara at http://www.facebook.com/tarapriyamusic Follow Tara at http://www.twitter.com/tarapriya Download the EP at http://itunes.apple.com/us/album/tara-priya-ep/id409149460 Topics: Sultry Songstress, Tara Priya, Tara
Rich Palmer of Audio Gumshoe brings you three songs and background info from the band, Bliss Bomb. Los Angeles based Bliss Bomb delivers a modern yet jazzy sound with a female fronted, ten-piece band. Their 2013 album, Fever Dream, takes you on a jazz-pop safari through outer space, the jungle, Hollywood and beyond. Seductive and fun, Fever Dream is a trip you won't want to miss! It is available on CDBaby, iTunes, and Amazon. Topics: jazz, pop, smokey, sultry, LA, Los Angeles
byCarmen Castillo, Xavier Cugat and his Waldorf-Astoria Orchestra
Alluring rendition by Carmen Castillo, vocalist in the orchestra of Xavier Cugat from a radio broadcast during the 1940's. Intensely emotional presentation enhanced by the sultry tones and accented lyrics. Carmen Castillo, second wife of Cugat, was featured in the Waldorf-Astoria Orchestra in the interval, 1931-1946. Whizbang!! Topics: Yours, sultry, vocal. 1940's, Xavier Cugat
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As sexy as their name suggests, Fever blends haunting and sultry blues ballads with witchy latin pop and cabaret sludge to create a truly unique sound that is nigh unclassifiable and always unforgettable. Formed in the summer of 2009 by couple Timothy and Natalie Valentine, Fever was soon joined by drummer Dhananjaya Zakheim. In December of 2009, the song âRoseâ was featured on Paradigm Recordings âDeath Aestheticsâ compilation. Soon after, the trio released their self-produced debut album,... Topics: fever, portland, oregon, sexy, sultry, gothic, victorian, cabaret, circus, rock, noir
ice cream dreams video by dj internet Featuring leza2unes,debbizo,KarmaHackeR, and Hemeleen For Sally Topics: marilyn monroe, sexy, sultry, jazz, sax, female vocals, dj internet, leza2unes, debbizo,...
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4 bands ,JAKE JOYCE,SEVERED VEIN,G.A.T. ,and THE DIRTY HEELS ,play several varieties of music ,from acoustic folk/punk ,to black metal ,to pop punk ,to sultry oldies styled numbers ,recorded live in Michigan at a living room St. Patty's Day party! great suff from all bands ,on BROWN BEAR RECORDS. Topics: jake joyce, g.a.t., severed vein, the dirty heels, danielle knorrek, sluggisha.blogspot.com, brown...


text:
|Publication number||US4990326 A|
|Application number||US 07/170,447|
|Publication date||Feb 5, 1991|
|Filing date||Mar 15, 1988|
|Priority date||May 31, 1985|
|Publication number||07170447, 170447, US 4990326 A, US 4990326A, US-A-4990326, US4990326 A, US4990326A|
|Inventors||Antoine A. Noujaim, Bryan M. Longenecker|
|Original Assignee||Summa Medical Corporation|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (7), Non-Patent Citations (2), Referenced by (6), Classifications (22), Legal Events (5)|
|External Links: USPTO, USPTO Assignment, Espacenet|
This application is a continuation of application Ser. No. 739,697, (now abandoned), filed May 31, 1985, and is also related to application Ser. No. 094,455, filed Sept. 9, 1987, and to application Ser. No. 740,253 (now abandoned), filed June 3, 1985.
The present invention is directed to a method for detecting blood platelets in a host using a labeled platelet binding antibody. The invention results from the discovery that the monoclonal antibody (MAb) 50 H.19 and fragments thereof react with blood platelets with high affinity and shows little or no binding to other elements in blood.
In accordance with this invention, the antibody is labeled to permit imaging after injection into the host. The labeled antibody can be reacted with platelets in vitro and then injected or the labeled antibody can be injected intravenously, in which case it will react with platelets in vivo. After an elapsed amount of time sufficient for the platelets to pass through the blood stream of the host, the host is scanned to image and detect locations of blood platelets. By observing the location and concentration of platelets, the method of the invention permits location and/or detection of various disorders including lesions of venous thrombosis, bacterial endocarditis, coronary arterial thrombosis, pulmonary emboli and atherosclerosis as well as organ imaging, such as spleen imaging. Because of the high sensitivity of the procedure, a high target-to-background ratio is achieved, thereby obviating the need to utilize background subtraction.
In accordance with another practice of this invention, the antibody is provided with an enzymatic thrombolytic agent and immunoreacted with platelets in vitro or in vivo as described above. The high platelet affinity of the antibody permits the thrombolytic agent to be carried to areas of high platelet concentration, such as thrombi, which is useful in therapy.
The monoclonal antibody 50H. 19 is selected by the murine hybridoma S.2.1. (registered with the American Type Culture Collection on May 17, 1985 and assigned the number HB 8807).
MAb 50 H.19 which is utilized in the method of the present invention is a biologically pure monoclonal antibody derived from hybridoma ATCC No. HB8807, deposited in the American Tissue Culture Collection. It is purified by known purification techniques, such as the protein-A purification technique. MAb 50 H.19 is more fully described in MacLean et al. (1982) J.N.C.I., 69, No.2, at 357-64, which is incorporated herein by reference.
The present invention relates to the use of the high platelet binding affinity properties of MAb 50 H.19 to detect blood platelets in a host thereby permitting detection of thrombi, emboli, arteriosclerosis and other disorders. MAb 50 H.19 antibody is immunoreactive with blood platelets of human beings as well as other species, e.g. primates and canines. The antibody, or fragment thereof, rapidly reacts with blood platelets and the majority of the bound antibodies remain bound to the platelets for a substantial period. Typically within fifteen minutes of being contacted with blood or blood platelets, no less than forty percent of the antibody is associated with the blood platelets. The bound antibody remains bound for several days. On the other hand, MAb 50 H.19 does not bind to white or red blood cells and relatively little (typically no more than 5%) is found in serum within a very short time after being introduced into the host. Specifically, MAb 50 H.19 and its fragments identified as Fab, Fab', and F(ab')2, as well as mixtures thereof, exhibit this high platelet affinity. References herein to MAb 50 H.19 are to be understood to include MAb 50 H.19 as well as the foregoing platelet specific fragments.
Because MAb 50 H.19 has a high affinity for binding to blood platelets, labeled MAb 50 H.19 can be used to detect the concentration and location of blood platelets in a host when the label is one which can be detected from without the host. For example, radiolabels which can be detected scintigraphically or NMR-labels which can be detected by NMR scanners may be employed. When the labeled MAb 50 H.19 is contacted with the blood platelets of a host, such as a patient believed to be suffering a disorder of the blood vessels, the labeled antibody immunoreacts with the blood platelets. Since the label can be detected from without the patient, it is possible to determine where the host's blood platelets are located and to observe the relative concentrations thereof.
Among the labels suitable for use with MAb 50 H.19 are radiolabels, such as radioactive isotopes of gallium, bromine, technetium, indium, and iodine. Specifically, Ga67, Br77, Tc99 m, In111, In113, I123, I125, and I131 are useful with MAb 50 H.19. The various techniques for radiolabeling are well known to those of ordinary skill in the art and are described in various available references. When radiolabeling with radioactive bromine or iodine, the chloramine-T method first described in Hunter et al. (1962) Nature (London), 194, at 495-96, or the iodogen method first described in Franker & Speck, Biochem. Biophys. Res. Commun. 80 at 849-57. or the methods reviewed in Saka, Radioimmunoimaging and Radioimmunotherapy, ed. Burchiel & Rhodes (Elsevier: 1983), at 171-84, can be used. For radiolabeling with radioactive technetium, the method described in Crockford et al. U.S. Pat. No. 4,424,200 is recommended, while the bifunctional chelate method described in Wensel & Meares, Radioimmunoimaging and Radioimmunotherapy, ed. Burchiel & Rhodes (Elsevier: 1983), at 185-96, is the preferred method when using radioactive gallium or indium.
The presently emerging technology in the field of labeling and imaging is nuclear magnetic resonance (NMR). Useful NMR-labels presently known include gadolinium (Gd) and other cations which will cause a signal shift of NMR. The technique for NMR-labeling suitable for use with MAb 50 H.19 is described in Lauffer, R. B., & Brady, T. J. (1985), "Preparation and Water Relaxation Properties of Proteins Labeled with Paramagnetic Metal Chelates," Magnetic Resonance Imaging, 3, at 11-16. As this technology further evolves, additional useful NMR-labels and techniques for NMR-labeling of antibodies will become known, the use of which is contemplated in this invention.
In the practice of the present invention, labeled MAb 50 H.19 is contacted with the blood platelets of a host and the labeled antibody and platelets are allowed to remain in contact for a period of time sufficient to allow the antibody to immunoreact with or bind to the platelets. An amount of labeled antibody sufficient to allow detection of its locations within the host by scanning means must be employed. References to an effective amount of labeled antibody refer to the level of labeled antibody which can be detected by scanning means. Labeled MAb 50 H.19 can be immunoreacted with the blood platelets either in vitro or in vivo. When reacted in vitro, a blood sample of from about one to about ten milliliters is removed from the host. The blood platelets are separated from the blood sample and then immunoreacted with the labeled antibody. The immunoreaction takes place in a physiologically acceptable liquid medium, e.g. dilute human serum albumin. The platelets and the labeled antibody are then allowed to incubate for a period of at least one minute and preferably at least fifteen minutes. The labeled platelets can then be intravenously injected into the host. For reaction in vivo, the labeled antibody may be mixed with a physiologically acceptable liquid carrier and the mixture may be intravenously injected into the host.
For either the labeled platelets from the in vitro reaction or the labeled antibody for in vivo reaction, after intravenous injection, a period of at least about two hours is preferably permitted to elapse prior to scanning the host, although the labeled antibody becomes bound to the platelets in as little as fifteen minutes. The more extended period of time allows the labeled platelets to circulate through the bloodstream and to accumulate at locations of blood platelet concentration.
In cases where a radiolabel is used to label the antibody, the suitable dosages are from about five to about thirty millicuries, and preferably from about ten to about twenty millicuries for a host having a body weight of 70 kg (154 pounds). The typical dosages for direct intravenous injection of the radiolabeled antibody are from about 0.001 to about one milligram per kilogram of body weight, preferably from about 0.001 to about 0.3 mg/kg body weight, and most preferably from about 0.015 to about 0.15 mg/kg body weight.
Because labeled MAb 50 H.19 indicates the location of blood platelets in the host's bloodstream, it is possible to detect a number of disorders by means of labeled MAb 50 H.19. For example, one may detect and locate thrombi by observing where the blood platelets to which the labeled antibody as bound are concentrated. Thus, labeled MAb 50 H.19 is useful in detecting arterial thrombosis and lesions of venous thrombosis. MAb 50 H.19 may also be used for spleen imaging. Further, emboli can be detected and located by observing those locations where the blood platelets exhibit a reduced concentration. Thus, MAb 50 H.19 can be used to detect pulmonary emboli. Atherosclerosis can be detected by observing the size of the blood stream through which the platelets to which the labeled antibody are bound are circulating and thereby detecting where atherosclerotic obstructions are located in the vessels. MAb 50 H.19 can also be used to detect bacterial endocarditis by observing where blood platelets are concentrated in the heart.
Because of its high platelet-specificity and strong binding properties, MAb 50 H.19 is useful in therapy to carry an appropriate agent directly to an area of high blood platelet concentration. For example, MAb 50 H.19 will bind with an enzymatic thrombolytic agent, such as streptokinase, and thence to blood platelets. As the blood platelets are carried through the bloodstream of the host, they will concentrate at thrombi and thereby deliver the thrombolytic agent to the thrombus to be treated.
The following examples are illustrative of the present invention and are not intended to limit the invention.
This example illustrates the platelet-specificity of the 50 H.19 antibody.
A sample of human whole blood was separated by conventional techniques into three factors: (1) platelets, (2) red blood cells, and (3) white blood cells. The three samples were adjusted so that each sample had about the same volume. Radiolabeled MAb 50 H.19 having a radioactivity of 150,000 counts per minute was added to each of the three samples. The samples with the radiolabeled MAb 50 H.19 were incubated for thirty minutes. Following incubation, the samples were spun down and washed with saline. The radioactivity of each of the samples was then measured to determine the amount of binding of the radiolabeled antibody to the cells or platelets. The sample of red blood cells and the sample of white blood cells each showed no significant binding. By contrast the sample of platelets showed between 40%.and 50% binding of the total input of labeled MAb 50 H.19.
This example illustrates the utility of labeled MAb 50 H.19 for imaging, detecting, and diagnosing thrombi.
A sample of MAb 50 H.19 radiolabeled with Tc99 m was prepared in accordance with the method of Example I of U.S. Pat. No. 4,424,200, which is incorporated herein by reference.
The evaluation of the radiolabeled antibody was performed in adult female mongrel dogs having a body weight of between 20 and 30 kg. Pentobarbital anesthesia was employed and no heparin was used throughout the experiments.
Experimental thrombi were induced by the transcatheter placement of copper coils into the common carotid, pulmonary and femoral arteries, the jugular and femoral veins, and the right ventricle. Thrombi were induced 1, 2, 3, 4, 8 and 48 hours before injection of the radiolabeled antibody. Thrombi were localized in situ by radiography of the copper coils and scintigraphy. Images were obtained 30 minutes after injection with a large field-of-view gamma camera (available from Ohio Nuclear, Solon, Ohio) interfaced to a Gamma-11 system (available from Digital Equipment Corporation, Waltham, Mass.), using a 64×64 matrix. Thrombus-to-background and thrombus-to-blood pool ratios were calculated. At the end of the experiments, the animals were sacrificed by injecting a 12 to 20 mg/kg dose of pentobarbital. In some experiments, the heart and lungs were excised after the death of the animal and analyzed by radiography and scintigraphy before recovering the thrombi, in others, the thrombi, blood and urine and the appropriate ratios calculated.
Venous and arterial thrombi could be consistently visualized as early as 1 to 3 hours after injection. Moreover, focal areas of increased uptake were also observed at sites of intimal damage associated with the experimental protocol, e.g. at sites of catheter entry, even though thrombi could not be identified at these sites at autopsy. Thrombi could also be visualized in segmental pulmonary arteries lying in front of the cardiac blood pool as well as within the right ventricle. No delayed imaging or blood pool subtraction techniques were necessary to identify the thrombi.
The 1, 2, 3, 4, and 8 hour old thrombi could be visualized with this technique. However, the 48 hour old thrombi (shown to be present at autopsy) had the same activity as the background body tissue and thus could not be imaged. Ratios of radioactivity in thrombi to radioactivity in blood were calculated from direct counts and were found to be between 2 to 15. These ratios confirmed the observations made visually on the scintiphotos.
Blood clearance studies were performed in dogs with doses of 0.5 millicuries of the radiolabeled antibody. For blood clearance determinations, samples were obtained at predetermined intervals from one minute to one day after injection. Urine samples of the 0-1, 1-2, 2-3 and 3-4 hour periods were assayed for radioactivity. Results were variously expressed as the percentage of injected activity per whole blood volume (calculated at 7% of body weight) or of injected dose contained in the total urine volume.
Within 3 to 6 minutes after injection, about 50% of the injected activity was cleared from the blood; imaging experiments indicated that the kidney was the major organ removing the activity from the circulation. 18 to 24% of the injected radioactivity was excreted in the urine within 1 to 3 hours. After incubating the radiolabeled antibody with the whole dog blood for 1 hour, 54 to 64% of the activity sedimented with the cellular fraction.
In all 9 dogs studied, no untoward side-effects were observed. Platelet counts before and after the injection of labeled antibody were performed in several dogs and any tendency for increased bleeding was monitored clinically. The doses of the radiolabeled antibody of up to 0.1 mg employed in these studies did not cause any changes in the dogs' platelet counts, nor was there evidence of a hemorrhagic diathesis or other symptoms.
This example illustrates the utility of labeled MAb 50 H.19 for spleen imaging.
A sample of MAb 50 H.19 radiolabeled with I131 was prepared by the conventional iodogen method.
Ten human cancer patients were intravenously injected with doses of between one and two milligrams of the radiolabeled antibody, comprising a dose of one millicurie. Serum blood samples were withdrawn from all ten patients at preselected times ranging from fifteen minutes after injection to two weeks after injection. The platelets were separated and the radioactivity measured to determine the percentage of binding of the radiolabeled antibody to the platelets. In all ten patients, the sample taken at fifteen minutes showed no less than 40% binding. The blood samples withdrawn in subsequent days showed no decrease below 40% binding, but rather remained essentially constant. These samples also showed less than 5% free radioactivity in the blood serum.
Imaging showed raw spleen uptake in accordance with the known distribution of labeled platelets in the spleen. No liver uptake occurred except for those patients having metastatic liver cancer. Some tumor uptake was observed for breast tumors, liver tumors, colorectal tumors, and melanomas. Tumor uptake was especially pronounced in those patients having had a splenectomy.
The injection and binding of the radiolabeled antibody had no effect on platelet function and no side effects of any sort were detected in any of the patients.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US4036945 *||May 3, 1976||Jul 19, 1977||The Massachusetts General Hospital||Composition and method for determining the size and location of myocardial infarcts|
|US4454106 *||Jun 7, 1982||Jun 12, 1984||Gansow Otto A||Use of metal chelate conjugated monoclonal antibodies|
|US4460559 *||May 4, 1982||Jul 17, 1984||Goldenberg Milton David||Tumor localization and therapy with labeled antibodies specific to intracellular tumor-associated markers|
|US4568544 *||Feb 26, 1985||Feb 4, 1986||Asahi Kasei Kogyo Kabushiki Kaisha||Aqueous solution of a tissue plasminogen activator dissolved therein at an increased concentration and a method|
|US4634586 *||May 21, 1984||Jan 6, 1987||The Board Of Trustees Of The Leland Stanford Junior University||Reagent and method for radioimaging leukocytes|
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|US4661586 *||Dec 2, 1983||Apr 28, 1987||The Board Of Trustees Of The Leland Stanford Junior University||Monoclonal anti-idiotype antibodies|
|1||*||Oster et al., Thrombus Radioimmunoscintigraphy: An Approach Using Monoclonal Antiplatelet Antibody, PNAS, 82, 3465 3468, May 1985.|
|2||Oster et al., Thrombus Radioimmunoscintigraphy: An Approach Using Monoclonal Antiplatelet Antibody, PNAS, 82, 3465-3468, May 1985.|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US5225181 *||Jan 21, 1992||Jul 6, 1993||The Research Foundation Of State University Of New York||Radiolabeled antiplatelet monoclonal antibody for imaging in-vivo thrombi|
|US5334369 *||Jun 11, 1991||Aug 2, 1994||Medical University Of South Carolina||Platelet receptor antagonists useful in detecting intravascular platelet aggregation|
|US5364612 *||May 6, 1991||Nov 15, 1994||Immunomedics, Inc.||Detection of cardiovascular lesions|
|US5632968 *||Nov 9, 1994||May 27, 1997||Immunomedics, Inc.||Detection of cardiovascular lesions|
|US20160144378 *||Nov 2, 2015||May 26, 2016||The General Hospital Corporation||Devices And Method For Enrichment And Alteration Of Cells And Other Particles|
|WO1992000083A1 *||Jul 2, 1991||Jan 9, 1992||The United States Of America, As Represented By The Secretary, U.S. Department Of Commerce||Platelet fibrinogen-specific monoclonal antibody|
|U.S. Classification||424/1.49, 424/153.1, 424/178.1, 530/808, 435/7.21, 424/9.34, 435/7.32, 436/548, 530/388.7, 530/809|
|International Classification||G01N33/569, A61K51/10, A61K49/16|
|Cooperative Classification||Y10S530/808, Y10S530/809, A61K51/1018, A61K49/16, G01N33/56966, A61K2123/00|
|European Classification||A61K51/10B18, A61K49/16, G01N33/569H|
|Sep 7, 1990||AS||Assignment|
Owner name: SUMMA MEDICAL CORPORATION, A NEW MEXICO CORP., NEW
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNOR:ZAMORA, PAUL O.;REEL/FRAME:005426/0472
Effective date: 19900821
Owner name: SUMMA MEDICAL CORPORATION, A NEW MEXICO CORP., NEW
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNOR:RHODES, BUCK A.;REEL/FRAME:005426/0470
Effective date: 19900830
|Sep 15, 1992||CC||Certificate of correction|
|Sep 13, 1994||REMI||Maintenance fee reminder mailed|
|Feb 5, 1995||LAPS||Lapse for failure to pay maintenance fees|
|Apr 18, 1995||FP||Expired due to failure to pay maintenance fee|
Effective date: 19950208

domain: biology


text:
The most lavish celebrity wedding celebrations of 2021
Paris Hilton, Jennifer Gates and more stars got hitched this year
Weddings are notoriously expensive, but for celebrities that may have more than a few dollars to throw at such an event, they often go over the top.
From multi-day celebrations to jaw-dropping venues and star-studded guest lists, celebrity weddings can certainly be something to behold.
2021 saw quite a few stars tie the knot, Paris Hilton, Heather Rae Young and Jennifer Gates among them.
While many kept their ceremonies intimate and low-key due to the ongoing pandemic, here's a look at some of the year's most lavish wedding celebrations.
INSIDE PRINCESS DIANA'S NIECE LADY KITTY SPENCER'S WEDDING FESTIVITIES: FROM A 'BOOZY HEN PARTY' AND MORE
The famously wealthy Hilton family added a new member to their ranks when Paris, 40, married Carter Reum on Nov. 11.
The party didn't just end there, however.
TAREK EL MOUSSA, HEATHER RAE YOUNG GET MARRIED: 'CHEERS TO FOREVER AND THEN SOME'
As documented in the Peacock docuseries "Paris in Love," the star and her new hubby celebrated over the course of three days. The two threw a couple of bashes to celebrate their big day, including one that was carnival-themed.
Hello magazine reports that the venue cost $61.5 million.
Bill Gates' daughter Jennifer married equestrian Nayel Nassar in October in a wedding that was expectedly lavish considering her father's fortune.
The ceremony and after-party took place on her sprawling 124-acre horse farm in North Salem.
PARIS HILTON MARRIES CARTER REUM: REPORT
While they were able to cut costs on the venue, reports suggested that there were large structures for guests to mingle in on the property, as well as high-quality bathroom structures, fancy flowers and a gorgeous gown.
Jen Glantz, founder of Bridesmaid for Hire and The First Years of Marriage, told FOX Business that she estimated the wedding's cost to be about $2 million.
Heather Rae Young and Tarek El Moussa
Reality stars Heather Rae Young and Tarek El Moussa tied the knot in October after teasing their upcoming nuptials for quite some time.
While details of their ceremony aren't very widely known, the pictures they've shared online showed off their stunning venue, lavish reception and decadent outfits.
MEGHAN KING SHARES PHOTO FROM WEDDING TO PRESIDENT JOE BIDEN, JILL BIDEN’S NEPHEW: ‘MR. AND MRS. OWENS’
Their wedding was chronicled in the HGTV special "Tarek and Heather The Big I Do."
Reality star Meghan King married President Joe Biden and First Lady Jill Biden's nephew Cuffe Owens in October in a small but special wedding.
The Bidens attended the happy ceremony in Pennsylvania. At the time, the White House described the event as a "small, family wedding at the home of Valerie and Jack Owens."
A BREAKDOWN OF JENNIFER GATES’ WEDDING COSTS FOR HER REPORTED $2 MILLION EXTRAVAGANZA: EXPERT
The nuptials were planned by his mother and Biden's sister, Valerie, and his sisters Missy and Casey. The guest list included 50 people and took place on the Owens' front lawn.
King wore an off-white blazer dress by Rasario and Owens donned a navy blue Ralph Lauren Purple Label suit.
Lady Kitty Spencer
Kitty Spencer, niece to the late Princess Diana, married billionaire Michael Lewis in Italy over the summer.
The black-tie ceremony took place at the sprawling Villa Aldobrandini in Frascati.
The big day was preceded by a bachelorette party thrown in honor of the then-bride-to-be on July 4, per the Daily Mail. Another celebration with her gal pals reportedly occurred the weekend before the wedding in Italy.
CLICK HERE TO READ MORE ON FOX BUSINESS
For their special day, Lady Spencer wore a cream lace dress with flowers and bows on it while Lewis paired a white button-down top with khaki pants.
FOX Business' Julius Young, Jessica Napoli and Lauryn Overhultz contributed to this report

domain: entertainment


text:
On a small street off Tubman Boulevard, the main thoroughfare in Monrovia, five red and white umbrellas shade stalls tended by five young men, all of them university students. In between classes, they sell mobile phone scratch cards and exchange grubby Liberian and US dollars. One of the students, 27-year-old Lorenzo Garmonyou, wakes up at 6am every morning and retires at around 1am in a cramped room he shares with his five brothers who also toil on the same corner.
Garmonyou is an economics student at the African Methodist Episcopal University. Like many young Liberians whose education was delayed during Liberia’s long and brutal civil war that ended eight years ago, he is struggling to put himself through school. From his small earnings he puts aside $2 a day to pay for his tuition and keeps a dollar to live on. Garmonyou is uncertain about the future in a nation whose economy is yet to create jobs for the few Liberians who are trained and educated.
Many unemployed graduates like Emmett Chea, a 24-year-old with an economics degree, complain that a culture of “nepotism” makes it difficult for qualified graduates to attain experience and jobs. He says they are yet to really feel the benefits of the billions of dollars of investment that came into Liberia during President Ellen Johnson Sirleaf’s first term. Analysts and government officials say that while there is a lot of work ahead to make Liberia’s economy one that benefits ordinary Liberians, the future still looks positive for Africa’s first republic.
Since Sirleaf’s election victory in 2006, Liberia has been relieved of its $4.6 billion debt by the International Monetary Fund (IMF) under the debt waiver of the Heavily Indebted Poor Countries Initiative (HIPCI). The country has drawn close to $19 billion in investment mainly in the form of mining, agricultural and oil concession agreements, from major companies such as ArcelorMittal, BHP Billiton, Union Sime Darby and oil majors like Total and Chevron.
With single digit inflation, a projected economic growth rate of 9.4% for 2012, up from last year’s 6.9%, there is an upward trend. All the more remarkable, so soon after a war that saw Liberia suffer one of the severest economic collapses recorded by any nation.
Despite this significant economic growth, Liberia remains among the poorest countries in the world, according to the United Nations Human Development Index. This is underscored by the extremely low rate of employment: only 15% of workers are employed formally and 79% of those employed are without a steady income, according to the Ministry of Labor. With 70% of the population below the age of 30, youth unemployment is regarded as one of the biggest threats to Liberia’s future.
In the wake of last year’s tense election, Sirleaf, now into her second term, acknowledged the need to create jobs and development.
In her annual address to the 53rd Legislature, she asked:
“How, then, do we transform our old economy from a plantation or concessionaire economy perceived to run for the benefit of a few, to a modern, inclusive economy?”
This big question is one that alludes to the difficulties of the past. Liberia’s 14-year civil war killed 250,000 and left the nation’s infrastructure in ruins. It drew into sharp focus the role economic disparities play in fomenting conflict.
Critics of Sirleaf’s government emphasize that income distribution has remained virtually the same since Liberia’s Poverty Reduction Strategy was introduced in 2008, with recent World Bank figures showing three out of four Liberians are still living below the poverty line. While there have been reports of a growing middle class in Africa—a recent report by the African Development Bank estimated that 4.8% of Liberia’s population can be considered middle class—this is the lowest percentage on the continent. The government is currently undertaking a project called Liberia Rising 2030, to replace the Poverty Reduction Strategy, with the goal of making Liberia a middle-income country over the next 18 years.
Liberia’s economy has been plagued by inequality since the nation was founded by freed American slaves in 1822, known as Americo-Liberians, who returned to Africa to create a new land of Liberty. Instead they ended up subjugating the native population and subjecting them to forced labor on plantations. Under the leadership of President Winston V.S. Tubman during the 1950s, Liberia had the highest economic growth rate in the world through its exports of iron ore, rubber, coffee and cocoa; yet it also had an extremely high poverty rate.
Liberia’s rapid economic growth and lack of national development led Robert Clower to publish an economic study on Liberia titled Growth Without Development that is now a seminal text in the study of post-colonial third world economies. During this time, growth merely benefited the few Americo-Liberians living in major cities such as Monrovia and excluded the rest. Yet even today, Liberia’s recent infrastructural restoration and development—electricity, paved roads, hospitals and running water—can be seen mostly in the seaside capital, Monrovia.
“Liberia traditionally has been a concession-based economy,” says Chairman of the Liberian National Investment Commission (NIC) Natty B. Davis.
“It’s an economy that produces what it doesn’t consume and consumes what it doesn’t produce to a certain extent.”
Davis says that granting major concessions to multinationals is to fuel economic growth to help reconstruct the country’s shattered infrastructure.
The civil war destroyed an estimated 75% of Liberia’s infrastructure, and left behind a generation of lost youths with little education. The war saw the end of the Mount Coffee Hydroelectric Dam, Liberia’s only source of electricity, which looters later stripped. The Liberian Electricity Commission started running again in 2010, but uses costly giant diesel-powered generators and charges 54 cents per kWh: the highest rate in Africa and among the highest in the world. Next month, with the backing of European partners the government will begin a four-year project to restore the dam to pre-war status that will cost an estimated $180 million.
Matt Jones is the director of a USAID-sponsored project called the Sustainable Marketplace Initiative. It works alongside the NIC and focuses on creating entrepreneurs in post-conflict countries. Jones says that energy is key to diversifying Liberia’s economy and creating opportunities for local businesses.
“It would be so much easier and cheaper to start a business here if you had access to electricity. People often rarely break even because their fuel bills are so extraordinary,” he says.
Jones argues that the major concessionaries will not necessarily create the jobs needed to cure Liberia’s unemployment problem, but will yield opportunity.
“Right now is a golden opportunity for Liberia. All of these big multinational companies are coming in and these local businesses have the biggest opportunity they have probably ever had to get contracts. These international organizations are actually very willing to talk to these businesses, work with them, try and get contracts with them, but they are still not going to bend on their standards,” says Jones.
Vaanii Baker, Program Officer for Investment Climate with the International Finance Corporation (IFC), says it is essential that Liberian businesses find a way to link up.
“If the country cannot figure out how to plug those small and medium enterprises (SMEs) into the growth that’s happening with the large concessions, they’re not going to realize the job growth that’s desperately needed in Liberia. The job growth is more than an economic issue in this country. With our recent history, I think it is more of a security issue as well,” says Baker.
Jones and those in government hope that increased levels of foreign investment will help fuel the rise of an entrepreneurial culture in Liberia, and in turn, economic growth. He sees signs of a more stable business climate emerging.
“The post-conflict situation has also played a role in this [lack of an entrepreneurial culture],” says Jones. “I think that people didn’t really have the opportunity to be an entrepreneur even if they wanted to and I think that people here are starting off on a basic level. But I believe that every single month and year after the conflict is just that much more positive for entrepreneurs and the commercial sector.”
Chid Liberty is a successful Liberian entrepreneur who co-founded a garment business called Liberty and Justice that exports its products to the States. He argues that entrepreneurship has a fundamentally important role to play in addressing poverty and rebuilding Liberia’s economy. Liberty’s father was the former ambassador to Germany under Samuel Doe, remembered by many as a brutal dictator. During the 1980s, Liberty and his family went into exile, but he returned to set up a business. The business employs 250 women in Liberia and Ghana, and is looking to expand. He says in order to meet his current demand, he would need to employ 2,500 workers.
“One of the core reasons we started our company is because we thought that what every developed economy has done so well is started really large industries that employ masses of people with low skills and education. There is no way that we are going to send all of these people back to university to get degrees to become journalists—give that up; the farm and the factory are the two places I think we need to place this lost generation of people,” he says.
Liberty says that Liberia needs to create an entrepreneurial class to generate jobs and bridge the deep economic divide in Liberia.
“Income inequality and people not having jobs are the biggest threats to Liberia’s security and all of our livelihoods.”
Building this class has become a focus for the Ministry of Commerce and Industry. Last year, the ministry officially launched its first micro, small and medium enterprises (MSMEs) policy called “Poverty Alleviation and Wealth Creation through Small Enterprise and Development” and is working with the NIC and its NGO partners to help entrepreneurs get their businesses off the ground.
Yuri Sobolev, the resident representative of the IMF, says that creating value-adding industries is the way forward for Liberia.
“Only the formal sector can create gainful employment opportunities, and value addition is the only way employment is going to be generated. For that you need better infrastructure,” says Sobolev.
“The government needs to create and enable environment [for the growth of businesses], physical infrastructure such as roads and electricity, to strengthen the rule of law with regard to business, contract enforcement and property rights.”
The government has made efforts to improve the business climate. With the help of the IFC it has set up a Business Reform Committee, with five committees focused on areas of the business environment that need to be reformed: electricity, finance, tax rates and procedures, customs and corruption. Liberia is also expected to connect to the Africa Coast to Europe (ACE) undersea cable system in October, which will bring its slow internet speeds up.
“While Liberia has many challenges ahead of it,” Baker says, “there is no reason it cannot become a middle-income country by 2030 and rival the booming economies of its West African neighbors.
“There is awesome potential for Liberia—it’s limitless. We’ve seen the development Ghana has had over the last few years… Within the next 10 years, if the government does the right things and puts in the right infrastructure, both soft and hard, in place, there is no reason why this country cannot surpass Ghana in terms of economic development and growth.”
Clair MacDougall is a journalist currently based in Monrovia, Liberia.
Liberia’s Gold Rush
In Sinoe County, in south-eastern Liberia, a handful of companies are
exploring land which is known to have large gold deposits; but which, due to the 14-year civil war, has remained untouched except by artisanal miners. The exploration area falls within the Biriman Craton, which holds gold and diamond deposits and extends through Ghana, Côte d’Ivoire, Guinea, Liberia, Mali and Burkina Faso. While exploration is in its early stages, companies believe they could strike upon larger deposits in coming years.
“We believe the gold potential here is enormous—just look at other countries that fall in the Biriman Craton. Our target is to be mining by the end of 2015,” says Tim Illingworth, manager of Hummingbird Resources, a company operating in the region.
Hummingbird Resources was founded in November 2005 and was listed on AIM in December 2010, raising $40 million. Hummingbird has a land package of 7,000km2 in Liberia and has currently only explored around 1% of that. The company reported finding 1.765m oz gold in September 2011, which they say dramatically increased on February 1 after a find of 2.052m oz, bringing the current total up to 3.817m oz. The company, founded by Dan Betts, claims it has made the largest gold discovery in Western Africa in the last year. Hummingbird currently holds a three-year exploration license and is in the process of negotiating a 25-year mineral development agreement with the government.
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domain: finance


Florence Residences sold 30 percent of released units on launch weekend
Report hints at lackluster new home sales in 2019 as developers struggle on from last year's cooling measures.
The Florence Residences along Hougang Avenue 2 was officially launched for sale last Saturday and has managed to sell around 60 units out of the 200 units released on over the weekend.
It was noted that most of the buyers at The Florence Residences were upgraders who are mainly looking at 2-bedroom and 3-bedroom units.
Developed by Hongkong-listed Logan Property (who is also the developer for Stirling Residences at Queenstown), the 1,410-unit private residential development is the first mega launch in 2019 and it is sitting on the site for former HUDC estate, Florence Regency.
According to estimates, Logan Property’s breakeven price for The Florence Residences is $1,340 psf and it was mentioned by the developer that the average selling price around $1,400 psf.
More than 200 units are sold at these new launch projects over the last month after official plans regarding the Cross Island MRT line was announced by the Land Transport Authority (LTA) on the final week of January 2019.
Since then, Affinity at Serangoon has sold around 100; more than 50 units at Riverfront Residences in the last 4 weeks.
As there will be more new launch condos to be released in 2019, market watchers believe that property developers will be cautious of their pricing strategy based on the projected demand within the vicinity.
Another 2 smaller private residential projects have also clocked in their first sales over last week, Nyon at Amber Road and The Essence along Sembawang Road.


(Pôrto Jofre) Instead of lush vegetation and abundant wildlife, the smell of burning, the glow of flames and desolation: the Brazilian Pantanal, a biodiversity sanctuary, is ravaged by fires.
France Media Agency
Felipe Maia, employee of a hotel who lived off ecotourism, tries to contain the advance of the fire by spraying with a pipe one of the wooden bridges that allow crossing the rivers on the Transpantaneira road of 150 km that connects Poconé to Porto Jofre, in central-western Brazil.
The region has suffered its worst drought in 47 years and many rivers are dry. Fires are relatively common this time of year, but this time around they are totally out of control.
About 23 500 Km 2 , near 12% of the largest wetland on the planet, which also extends to Paraguay and Bolivia, has already gone up in smoke since the start of the year.
“Every day, we pass on this road and as soon as we see an outbreak of fire nearby, we spray the bridges to prevent them from burning in their turn”, Felipe Maia explains to AFP , a few meters from an area covered with burning mounds.
Many residents, tourist guides, employees and owners of farm inns lend a hand to the firefighters day and night.
Animals in “critical condition” 2020
” It’s sad. We suffered the pandemic, which lasts longer than expected in Brazil, and we thought we would soon have a good tourism season, but the fires have arrived, ”laments Roberto Carvalho Macedo, tourist guide who is part of these volunteer patrols.
The satellites of the National Institute for Space Research (INPE) have identified 1 er January to 13 September 14 764 fire outbreaks in the Brazilian Pantanal, an increase of 214% compared to the same period last year. The record for a whole year (12 500 outbreaks) has already been largely beaten, in just over nine months.
Roberto Carvalho Macedo is piloting a boat on which an AFP team plies the rivers of the Encontro das Aguas natural park, a large flood zone that begins where the Transpantaneira ends.
The green landscape of the river banks contrasts with the black and gray tone of the charred trees.
You can usually see a wide variety of animals there: caimans, giant otters, anteaters, not to mention the largest feline in the Americas, the jaguar.
Accompanied by a team of veterinarians and biologists, the young guide Eduarda Fernandes Amaral spent Sunday looking for a jaguar injured by fire, but the animal did not appear.
“All the animals that we were able to help were in very critical condition, with burns to the bone”, she explains, while installing makeshift feeders with water and fruit.
Animals that survive the flames may die of hunger or thirst.
Eduarda Fernandes Amaral admits that it is impossible to calculate precisely the number of animals affected, but assures that the losses are enormous.
“I hope at least these images allow people to open their eyes and understand that the biodiversity we have here is unique. We need to preserve it, it is very precious, ”she sums up.
“Feeling of impunity” 2020
These unprecedented fires are above all due to the exceptional drought: from January to May, it rained half as much as expected and many areas were not flooded as is usually the case.
But specialists consider that other factors must be taken into account, in particular the substitution of native vegetation by plants from outside intended for pasture which burn more easily.
Not to mention the “feeling of impunity” that reigns due to “the lack of resources for public environmental protection bodies”, denounces Vinicius Silgueiro, of the NGO Institut Center de Vie (ICV).
Many environmentalists criticize the environmental policies of far-right President Jair Bolsonaro, whom they blame for the upsurge in fires in the Pantanal and the Amazon.


text:
With a history that spans more than 100 years, the Georg Jensen brand represents quality craftsmanship and timeless aesthetic design. Jensen's artisanal skill and artistic talent combined with his ability to identify and support design talent was the foundation on which he built Georg Jensen in Copenhagen in 1904.
Made from Sterling Silver, designed Henning Koppel for Georg Jensen.
Care: Hand wash. Polish with microfibre cloth and silver polish.
Special Order, delivery is based on stock availability.
Should you have any questions, please contact us directly at firstname.lastname@example.org or 416.926.1120 / 1.866.926.1120.
5.8"L (15cm) • ITEM 5GJ-SSI-CAR-CHI-SPN

domain: design


text:
- Author : Sir Arthur Conan Doyle
- Publisher : Sterling Publishing Company, Inc.
- Release : 20 January 2022
- ISBN : 1402712170
- Page : 151 pages
- Rating : 4/5 from 77 voters
Download or read online book entitled The Adventures of Sherlock Holmes, was written by Sir Arthur Conan Doyle and published by Sterling Publishing Company, Inc. in pdf, epub and kindle format. This book was released on 20 January 2022 with total pages 151. Amateur detective Sherlock Holmes, the master of deductive reasoning, solves several mysteries with the aid of his friend, Dr. John Watson.

domain: literature


text: Purpose Genetically engineered mouse (GEM) models of ovarian cancer that closely recapitulate their human tumor counterparts may be invaluable tools for preclinical testing of novel therapeutics. volume and bioluminescence imaging, in vitro by WST-1 proliferation assays, and in OEA tissues and cells by immunoblotting and immunostaining for levels and phosphorylation status of PI3K/AKT/mTOR signaling pathway components. Results Murine OEAs developed within 3 weeks of AdCre injection and were not preceded by endometriosis. OEAs responded to cisplatin + paclitaxel, rapamycin, and AKT inhibitors in vivo. In vitro studies showed that response to mTOR and AKT inhibitors, but not conventional cytotoxic drugs, was dependent on the status of PI3K/AKT/mTOR signaling. AKT inhibition in APC?/PTEN? tumor cells resulted in compensatory up-regulation of ERK signaling. Conclusion The studies demonstrate the utility of this GEM model of ovarian cancer for pre-clinical testing of novel PI3K/AKT/mTOR signaling inhibitors and provide evidence for compensatory signaling, suggesting that multiple rather than single agent targeted therapy will be more efficacious for treating ovarian cancers with activated PI3K/AKT/mTOR signaling. alleles (6). Genetic alterations that dysregulate the canonical Wnt (i.e., Wnt/-catenin/Tcf) and PI3K/Akt/mTOR signaling pathways often occur collectively in human being ovarian endometrioid adenocarcinoma (OEA) (7, 8). Given considerable overlap in the molecular features (gene manifestation and mutational profiles) of tumors diagnosed as high grade OEAs, with high grade 100935-99-7 IC50 serous carcinomas (7), some pathologists default the majority of gland-forming or near-solid cytologically high-grade carcinomas to the serous category, and consider true high-grade OEAs to be rare or non-existent (9). If only low grade (prototypical Type I) OEAs are considered, the majority possess mutations expected to dysregulate canonical Wnt and/or PI3K/Akt/mTOR signaling and is usually wild type. Loss of function mutations in (which encodes the AT-rich interactive domain-containing protein 1A) have also been recently reported in 30% of OEAs (10). Given the rate of recurrence with which Wnt and PI3K/Akt/mTOR signaling is definitely triggered in OEAs, medicines that target these pathways might prove to be particularly useful for treating individuals with advanced-stage disease or in the adjuvant establishing for individuals with OEA who might be at risk of recurrence. Given our limited ability to exhaustively test multiple drug mixtures, doses, and schedules in medical trials, it is anticipated that animal models which closely mimic their human being disease Rabbit Polyclonal to STAG3 counterparts will provide an invaluable tool for the recognition of multi-drug 100935-99-7 IC50 regimens with very best promise for effectiveness in humans. We previously explained a murine model of (Type I) OEA based on conditional inactivation of the and tumor suppressor genes following injection of adenovirus expressing Cre recombinase (AdCre) into the ovarian bursae of mice (7). Several characteristics of this mouse model suggest its relevance and tractability for screening novel restorative approaches. First, complicated breeding schemes are not needed to generate mice with 100935-99-7 IC50 the appropriate genotype once a breeding colony has been founded. Second, tumors invariably arise within a few weeks following AdCre injection, and recapitulate the morphology and gene manifestation pattern of human being OEAs with similar signaling pathway problems. Third, tumors arise in the ovary and in immunologically undamaged animals, so possible effects of the tumor microenvironment on restorative response can be assessed. Finally, much like ladies with advanced ovarian malignancy, three quarters of the mice develop hemorrhagic ascites, and nearly one quarter acquire overt peritoneal dissemination. To demonstrate this models energy for pre-clinical screening of novel therapeutics focusing on the PI3K/Akt/mTOR signaling pathway, we pursued proof-of-principle studies demonstrating the response of murine OEAs to standard chemotherapeutic medicines (cisplatin and paclitaxel) and mTOR and AKT inhibitors in vitro and in vivo. Additionally, we demonstrate the application of a Cre-inducible luciferase reporter allele for longitudinal in vivo monitoring of tumor development and drug response in the mice. MATERIALS AND METHODS Mouse strains and tumor induction mice and ovarian bursal delivery of replication-incompetent recombinant adenovirus expressing Cre recombinase (AdCre) have been described previously in detail (7). Briefly, Cre-mediated recombination in these animals results in a frameshift mutation at codon 580 (11), and the deletion of exons 4 and 5 of (12). For tumor induction, 5.


It's a while since I've been on the forums and I hope everyone's getting things done and helping fellow modders. I come to you with an enquiry about rotating models. It's probably the easiest fix but for the past few months I've only been focusing on blocking out the maps I'm working on for Total Recall, and because of this I usually forget how to script not long after learning, as my mind is else where on the project.
I'm right now working on the final level for TR (Yay!) and I'm trying to make use of the rotating rings from Enpro Plant.
My aim is to have Quaid running through a centrifuge while these models rotate around him and was just wondering what I need to make the model rotate on the axis shown below.


text:
Come Cmitche2 ha cominciato il suo viaggio per il design di design di stampa o packaging
We are a small boutique winery producing chardonnay and semillon wine in Lovedale in the Hunter Valley Australia. We have a logo and require a wine label design. We have 3 wines; a sparkling chardonnay called Truly, a chardonnay called Heart and a semillon wine called Soul.
Dicci qualcosa su di te e sulle persone che vuoi raggiungere
There is no specific target audience, but we are looking for the design to be more refined and classic with a pinch of fun, using black red and white colours.
We have attached our logo (file called logo) and 3 very rough design sketches (design1, 2 and 3). For the design for the wine called Heart we are looking to reshape the logo to use the shape of a heart in some way. In our business cards we replace the "o" in lovedale with a small red heart. Lovedale is known as the heart of the Hunter Valley due to its shape on the map. Also need the year 2011 and 750ml written somewhere.... this is the front label to a bottle.
Contest veloce (fast track)
Abbiamo trovato dei contest simili che potrebbero interessarti

domain: artistic


Select committee chairman Ian Davidson hits out over blacklisting response
Major contractors “can’t be trusted” because of their history of blacklisting and their response to the scandal, the chairman of a Commons select committee said today.
Speaking at a hearing of the Scottish Affairs Comittee - which has been investigating blacklisting in the industry since June last year – chairman Ian Davidson said it was clear from the evidence the committee has taken that the contractors involved “regret being caught” rather than genuinely regretting the practice.
More than 40 main contractors paid the now defunct firm the Consulting Association (TCA) for access to a 3,200 name blacklist up until the organisation was exposed and shut down in 2009.
The committee has taken oral evidence from witnesses including Sir Robert McAlpine director Cullum McAlpine, Balfour Beatty’s then UK Construction Services chief executive Mike Peasland and Harvey Francis, executive vice president of human resources at Skanska.
Davidson claimed the firms involved with TCA had not properly reformed their operations or made amends for blacklisting.
He said: “We’ve come to the view that contractors can’t be trusted.”
He later added: “They are all as guilty as sin as far as I can see…the major contractors.”
In its interim report in April, the committee said it was “unconvinced” that Balfour Beatty regretted its involvement with TCA.
It also said it was concerned by the failure of firms including Balfour Beatty and Skanska “to hold any individual to account” for wrongdoing and said it was not persuaded by Cullum McAlpine’s claim that he had a “hands off” role as the founding chairman of TCA.
James Wates, chairman of the UK Contractors Group said: “British construction firms deserve better than this glib description. They employ British workers, deliver British jobs and build the homes, schools, hospitals and offices upon which we depend. Blacklisting is an afront but so too is this gallery playing.”
The committee today took evidence from EDF Energy, which has created a widely-admired industrial agreement with trade unions and contractors to oversee the £16bn Hinkley Point C nuclear power plant.
The agreement includes several anti-blacklisting provisions.
Nigel Cann, EDF’s site construction director for the project, said the agreement included a fully directly-employed workforce and an ‘employment affairs unit’ run by EDF but including union and contractor representatives to monitor compliance with the agreement.
He said: “That provides the governance to make sure that the agreement is deployed.”
Asked about blacklisting, he said contractors would face fines or removal from the project if found to be doing it.


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2017 marks the 30th anniversary of the non-profit educational institution and cultural embassy Tibet House US.
The 2017 benefit concert will take place on March 16th at New York City’s Carnegie Hall. Iggy Pop, Patti Smith and her Band, Laurie Anderson, and New Order members Bernard Sumner, Phil Cunningham and Tom Chapman top the bill. Also performing will be Tenzin Choegyal and Jesse Paris Smith, Scorchio Quartet, Lavinia Meijer and more.
The punk icon has recorded five new tracks, all of which appear to be collaborations with other artists.
“I’ve made five recordings since then,” he told Entertainment Weekly.
“But they were all recordings not where I’m about, ‘Hey, I’ve got something to say!’ No, it was just, people called me up and said, ‘Do you want to do a vocal with me, about this, under this circumstance?’ More like guesting.”
He added: “I would prefer to do that for a while. You know, there are people I like. I like the people I’ve recorded with — I can’t tell you who they are! — very much.”
The punk icon, who is now 69, had hinted in June that he may never make another album.
“I will step back at some point,” he said on an episode of The Graham Norton Show. “Another album would be a big undertaking from an old git like me!”


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Send flowers to Saldanha
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Flower deliveries to Saldanha, Western Cape
Saldanha, also known as Saldanha Bay, is a town of 21,636 people, located 110 kilometres (70 mi) north of Cape Town on the northern shore of Saldanha Bay, in the Western Cape province of South Africa. Its situation as a natural sheltered harbour has led to development as a port for the export of iron ore from Sishen in the Northern Cape, which is transported on the Sishen–Saldanha railway line. The port is one of the largest exporting ports of ore in the whole of Africa, and it is able to handle ships as large as 200 000 tons deadweight.
We pride ourselves on delivering flowers to Saldanha, it's suburbs and surrounding areas.

domain: geography


text:
Morris Arts leader lobbies for NEA funding in Washington
The president may be proposing to defund the National Endowment for the Arts, but if Morris Arts Executive Director Tom Werder and Morris County's representatives in Washington get their way, a properly funded arts community will continue to enrich both the culture and the economy.
Werder traveled to the nation's capitol last week to participate in a Capitol Hill press briefing as one of seven speakers representing Americans for the Arts, a national nonprofit advocacy group.
Werder and other regional arts leaders explained cultural importance of the arts to the assembly of about 60 staffers, most representing House members, but also stressed the significant impact of the arts on local economies.
Werder summed up his argument with four words: "The arts mean business."
"The arts may be food for the soul, but it's really food on the table for people who have jobs that are arts-related, who are employed in restaurants that are full because of these arts events that are happening, or for the retail owners who have foot traffic because of the activity that the arts generate in our town," Werder said. "This is big business that happens to be arts."
In Morris County alone, $31.8 million was generated last year from arts activity, which also supported 982 jobs, according to an Arts in Economic Prosperity study.
That same study reports $520 million in annual economic activity generated by the arts, 14,000 jobs supported and $41 million returned to state and local funds.
Werder said he spoke to a receptive audience, knowing he already had two key legislators on his side — Republican Reps. Rodney Frelinghuysen and Leonard Lance, who between them represent Morris County in Congress.
By then, both had expressed public support for continued funding of the NEA. Frelinghuysen, in fact, had already bucked the president on the issue as chairman of the House Appropriations Committee, agreeing to put $145 million in NEA funding back into the fiscal 2018 budget.
That figure represented a $5 million drop from the $150 million budgeted for fiscal 2017. Werder said he was grateful for that support, although he and his fellow Americans for the Arts representatives are lobbying for an increase to $155 million for fiscal 2018.
"I got the chance to sit with Rodney in his office," Werder said. "We thanked him for speaking out publicly in support of the NEA."
Frelinghuysen told Werder that $145 million was not a lot of money in relation to the overall budget — "He said it's almost a rounding number," Werder said.
"He knows our organization quite well, he personally donates to Morris Arts," Werder said. "He shows up for our events, so he understands our importance of the arts in his district."
Frelinghuysen also agreed to support the $155 million proposal should it clear the Senate Appropriations Committee, Werder said.
Lance, meanwhile, attended and spoke at the press briefing along with Werder as co-chair of the Congressional Arts Caucus.
"He's a longtime supporter of the arts," Werder said. "He spoke about how this is a bipartisan issue, and he's part of leading the charge in that way. So it was great to have him there."
As an arts leader in a Congressional district represented by key appropriators in the budget process, Werder was chosen as one of the speakers to represent Americans for the Arts. The list of presenters also included well-known musician Ben Folds, who spoke just before Werder.
"Who knew that Ben Folds would open for me?" Werder joked during his remarks in Washington. "I used to say that I worked for an arts organization, but now I refer to us as a community-building organization, one that is uses the powerful arts as a tool to bring our community together to create a place where people want to live, work and play."
Armed with economic statistics and other related data from the Arts in Economic Prosperity study, all the speakers pushed the prospect of how every dollar invested in the arts is returned tenfold back into the community.
But Werder made sure to stress the cultural impact as well, particularly in Morristown, where Morris Arts, the Mayo Center for the Arts and other cultural programs have helped to revitalize the town.
He spotlighted the recent Gateway Totem project in Morristown, funded by public and private dollars.
"For the past decade, arts activities in our community and our schools have created a vibrancy in Morristown," he said. "Businesses are moving to the area and new housing stock is being built because of this vibrancy. But there's a part of Morristown in the neighborhood that streams away from the thriving downtown, where our immigrant population has settled for the past century. We wanted to create a place of public art honoring all the immigrant populations that have settled there over time, and we wanted it to be monumental and permanent."
The Gateway Totem project erected two stone-carved totems with unique icons, each representing a unique Morristown community that has called the Speedwell area home through the years: Italian, Irish, Jewish, African-American, South and Central American.
"We were awarded $20,000 from the NEA, and the developer across the street donated $50,000, and thousands more were donated by individuals throughout the community," Werder said, "That's how it works. We placed them right at the intersection where these two parts of Morristown meet. Right in front of the community garden, right next door to the low-income senior housing, down the street from the high school and across the street from a brand-new apartment complex, and another one under construction."
The totems were unveiled last November, just after election day.
"With this space, we've created a creative place for the immigrant community to come together and express themselves with art from their own cultures," Werder said.
Staff Writer William Westhoven: 973-917-9242; firstname.lastname@example.org.

domain: sociology


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Academy Sports and Outdoors set for Rayzor Ranch Marketplace
Academy Sports and Outdoors will open a 72,000-square-foot store in Denton later this year, the latest retailer to sign on with Rayzor Ranch Marketplace.
This will be the 17th Academy store in the Dallas-Fort Worth area and will start the third phase of development at the Marketplace.
“We’re always looking to expand, and we’re excited to offer Denton a location to be a one-stop shop,” said Allan Rojas, senior communications coordinator for Academy.
The store is also expected to add about 150 jobs, which will be a mix of full-time and part-time positions, he said.
The location is expected to provide a large boost to the development, said Linda Hinton, general manager of the center for RED Development, the developer in charge of Rayzor Ranch Marketplace.
“It’s going to greatly help the project overall,” she said. “We’re really positioning ourselves for Rayzor Ranch Marketplace to be the place for shoppers in Denton to come shop, dine and get things done.”
Academy has been interested in adding a Denton location for a few years, but was waiting for the economy to pick back up, and to find the right location, said Aimee Bissett, director of economic development for the city.
The closest competitor to the incoming store will be Sports Authority on Loop 288, Bissett said.
“As other stores have come online at Rayzor Ranch, we haven’t seen sales tax revenue go down in Denton Crossing, and that’s where Sports Authority is,” she said. “What we’re seeing is that we’re drawing a market that has been going outside of Denton, and is now staying inside Denton to meet their shopping needs.”
While Hinton and Rojas would not provide a project timeline, Bissett said she anticipated construction starting by the end of the month and the business opening later this year, potentially as early as October.
With this and other anticipated additions this year, such as Ross Dress for Less and Salons by JC, Hinton said she anticipated even higher levels of traffic at the development this year.
“They are going to fill a nice niche for us and the community, and it certainly fits well with everything else we have to offer at Marketplace,” she said.
JENNA DUNCAN can be reached at 940-566-6889 and via Twitter@JennaFDuncan.


Joel is a Grammy Nominated Singer-Songwriter. His soulful rendition of “Shake It Off” quickly catapulted his career, capturing the attention of Capitol Records, multi-Grammy award-winning artist India Arie and fans around the globe. Joel grew up singing gospel songs with his seven siblings. His heartfelt approach showcased his ability to make each piece sound new, truly a sound all his own. One afternoon, while playing the Dallas Arboretum, Joel decided to appease the crowd’s unconventional request for a song by Taylor Swift. A fan happened to catch his very soulful rendition of “Shake it Off” on video and uploaded it to YouTube. By the next morning, it had over half a million views, and Joel’s face was on every major news source in Dallas. The viral video quickly catapulted his career as he captured the attention of fans across the globe, including Ellen DeGeneres, America’s Got Talent, Capitol Records, Time, and MTV. Four-time Grammy award-winning artist, India Arie, was also intrigued by Joel when she heard one of his original songs, “Candlelight,” and invited him to collaborate with her on her upcoming album. That album was Songversation: Medicine and it was nominated for Best New Age Album in 2017. Joel is currently working with India on her next project, Worthy.


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Former NSYNC star Lance Bass to marry boyfriend Michael Turchin
- From: News Corp Australia Network
- September 03, 2013
SEEMS NSYNC reuniting at the VMAs wasnt the only highlight for Lance Bass over the past week.
He also became engaged to boyfriend, model and actor Michael Turchin, posting a photo of himself with his new fiancé on Instagram, with the message “He said YES!! Love this man @michaelturchinart.”
One day earlier, Turchin tweeted, “Happiest guy in the world :).”
After the VMAs, where he took the stage with his old band for the first time in years, Bass tweeted, For the first time ever I got to perform w *NSYNC as an out entertainer and was thinking of this man," he tweeted, along with a photo of him and Turchin in front of an MTV moonman.
Bass was previously linked to US Amazing Race winner Reichen Lehmkuhlin and Brazilian model Pedro Andrade.
Bass and Turchin began dating in 2011 and were engaged in New Orleans, where they were said to be spending the US Labor Day holiday weekend. "They're such a great couple, everyone is so happy for them," a friend of the couple said. “Their friends and family are thrilled.”
Bass came out as gay in 2006, and told People magazine two years ago that he dreamed of having a “family and kids”.

domain: celebrity


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Never miss another 'The Cadillac Kings' show
Darlington R'n'b Club: The Cadillac Kings
"The Cadillac Kings are possibly the current number one British Blues band playing both the West Coast and New Orleans Blues-Styles. Their stage performances are highly entertaining and their energy and virtuosity is what makes their live performances so dynamic.
Tickets available from the Forum Music Centre."
Info provided by the Event Organiser
The award winning Cadillac Kings play blues, swing, boogie, jump-jive and rock n roll with the look, sound and intentions of the 1950s. This band has a reputation for wowing their audiences from theatres to dance-halls, from clubs to festivals, across the UK and Europe.
"The UK's premier blues & roots act" - John Clarke, The Times.
"Good time blues at its very best - do not miss these guys" - Lionel Ross, Blues in Britain.
"One of the UK's finest band's in any genre" - Grahame Rhodes, Liverpool Echo.
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Venue: The Forum Music Centre
Phone: 01325 363135
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→ Darlington 9 min walk


text:
13 And the LORD said unto Abraham, Wherefore did Sarah laugh, saying, Shall I of a surety bear a child, which am old?
14 Is any thing too hard for the LORD? At the time appointed I will return unto thee, according to the time of life, and Sarah shall have a son.
15 Then Sarah denied, saying, I laughed not; for she was afraid. And he said, Nay; but thou didst laugh.
I remember as a teenager I developed an attitude. My mother or father would tell me to do something and I would mutter something so low that they couldn’t hear it. My back would be turned and everything, but still before I could take a step I would hear, “that’s fine son, you want to mumble that, then your grounded.” It always took me by surprise and I would have to stand there for a minute to realize what just happened. Think of how Sarah felt when they knew she laughed within. She wasn’t setting with them and did not laugh out loud, she laughed within and was called out on it. She thought yea right there is no way I am carrying a child. We are all guilty of hearing a preacher tell us God can and will bless us and thinking, yea right. I will admit when my wife and I were having trouble starting a family, many would tell me God will bless you with children. I always thought, yea right that’s never going to happen. Just like Sarah I had to repent for doubting God. You see nothing is to great for God to do. He is God. So before you laugh and think it can’t happen, realize if he said he will do it, than it will happen. Don’t doubt what he can do. Only be prepared to recieve his blessings.


text:
Source: Internet, ResearchAndMarkets.com, Championpetfoods, Royal Canin (Mars Inc.), United Pet Group Inc.
The Pet Food Market in China and Japan has USD 8 Billion value in the year 2019, the whole pet care markets have been derived by the pet food segment of the region, as a report said in Asia Pacific Pet Food Market Overview 2020–2025, recently released by Research and Markets.
The report titled “The Asia Pacific Pet Food Market, Overview, 2020–2025” gives the complete analysis of Asia Pacific’s pet market and its region-wise developments. The global pet care market is growing at a dramatic rate which is witnessing a gradual upsurge in pet ownership as well as spending on various pet care products. Among the top revenue-generating regions from the pet care market, Asia Pacific is viewed as one of the major pet care markets globally. In the last couple of years, the pet care industry has seen rapid growth as the owners have developed a behavior of family members towards the pets and are very much lean towards providing them with all the facilities.
Globally, there are some famous players who hold the majority of shares in pet care. It is well expected that the market will see a lot of new players which is going to take the competition to a new level. Some of the major companies present in the market are as follows:
Nestle SA, Mars Incorporated, Colgate-Palmolive, JM Smucker, Blue-Buffalo, United pet group inc, Champion pet food, PLB international, Scott Pet Inc, Unicharm Inc, Laroy Group, Deuerer GMBH, Heristo AG, Well Pet, Proveedora La Perla S.A. De C.V, NicoluzziRacoes, Raw Gold, Promeal Ltd, Heritage foods Kenya ltd, Lider pet foods, De Haan Pet Food.
The changes observed in the pet owners are due to the technology and advent in online purchasing. This report provides a better insight into the pert care performance of various countries included in this region with historical and forecasted analysis.