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FDA Approves Ocrevus as 1st MS Treatment for Both Relapsing and Primary Progressive Forms
At long last, and for the first time in medical history, people with both relapsing and primary progressive forms of multiple sclerosis have reason to celebrate. The U.S. Food and Drug Administration (FDA) today approved Ocrevus (ocrelizumab) as a disease-modifying therapy for both forms of MS, a chronic autoimmune disease.
The FDA’s decision is historic for primary progressive (PPMS) patients, who until now had no accepted means of slowing the relentless march of their illness, and it’s historic for relapsing MS patients — studies showed that Ocrevus effectively halted the disease in nearly half of treated RMS patients.
It’s also historic for the future of MS research and treatment. Ocrevus defied all norms by targeting immune system B-cells and, in clinical studies, surpassed most expectations to become what may be the most powerful drug yet developed against MS.
“The FDA’s approval of OCREVUS is the beginning of a new era for the MS community and represents a significant scientific advance with this first-in-class B-cell targeted therapy,” Sandra Horning, MD, chief medical officer and head of Global Product Development at Genentech, said in a late-breaking press release.
European health authorities are also reviewing Genentech’s request for EU approval (called a marketing application), and decisions in other countries are likely to follow.
“This is an exciting day for everyone touched by MS, a disease that strikes in the prime of a person’s life when she or he may be starting a career or family. For many people living with MS, this FDA approval is a source of hope,” said June Halper, chief executive officer at the Consortium for MS Centers, said in the release.
“[I]f everything works out, it looks as if Ocrevus, although not a cure, has all the makings of a wonder drug for MS, at least for most people who have the disease,” Ian Franks, chief columns editor for BioNews Services, the parent company of Multiple Sclerosis News Today, wrote earlier this month, adding that the March 28 choice of approval date was “quite poetic really, in that it is MS Awareness Month.”
Upon learning of the FDA’s action, Franks said: “While there are other DMTs [disease-modifying twroteherapies] for relapsing MS, I find it tremendously encouraging that Ocrevus has been approved for treating primary progressive. Looking to the future, perhaps we might not be so far away from developing treatment specifically for secondary progressive.” Franks, who was diagnosed with multiple sclerosis in April 2002, has non-relapsing SPMS.
B is the new buzz
Ocrevus is not just another MS treatment. It is the first with demonstrated benefit for primary progressive patients, using a new approach in fighting MS. Most treatments focus on keeping immune T-cells in check, but Ocrevus works to prevent certain B-cells from doing harm.
About 15 years ago, Genentech started exploring with academic researchers the importance of B-cells in MS. It soon became apparent that B-cells carrying the CD20 molecule on their surface played a more prominent role in disease processes than previously thought.
Early experiments with B-cell depletion eventually led to a Phase 2 study (NCT00676715) of Ocrevus, a drug that had failed trials in other autoimmune conditions.
In 2011, nearly two years into that study and patient treatment, Genentech surprised many when it announced that two-thirds of the people given this B-cell-based therapy were free from any disease activity: no new brain lesions, no relapses, no progression in neurological disability. Findings led the trial’s lead investigator to call the results “among the most remarkable seen in a phase II RRMS study.”
Development continued, with an expanded view. A Phase 3 clinical trial program was launched with two studies in relapsing MS — the OPERA I and OPERA II trials (NCT01247324 and NCT01412333) — and a third, ORATORIO (NCT01194570), to assess whether Ocrevus might also benefit primary progressive patients.
Early reports of considerable efficacy across all three trials were announced in 2015. Full trial data followed, published in December 2016, dispelling doubts that Ocrevus had the potential to be quite effective. (Genentech is continuing to analyze data from these studies.)
That same month, however, the FDA surprised and disappointed many by delaying an expected decision on Ocrevus. The agency’s postponement did not reflect concerns about Ocrevus’ effectiveness or safety, Genentech announced; rather, it was due to questions about the drug’s manufacturing process. A new decision date, March 28, was set.
What makes Ocrevus so successful, and what exactly does this success look like?
Results from the clinical trials suggest that CD20 B-cells directly cause damage to the myelin sheath — an insulating layer allowing signals to pass swiftly through neuronal extensions, known as axons. Researchers also believe that these B-cells damage the neurons themselves.
“The ocrelizumab Phase 3 studies have redefined our understanding of the underlying biology of MS and shows that B-cells, a type of immune system cell, play a central role in the disease,” Dr. Peter Chin, a neurologist and principal medical director of Global Neuroscience Development at Genentech, said in a February interview with Multiple Sclerosis News Today.
The new findings do not invalidate earlier claims of T-cell involvement in MS, as Chin pointed out in a 2015 interview with this news website. The science so far, he said, supports the idea that B-cells work together with T-cells to create the inflammatory brain lesions, and resulting disability progression, seen in MS.
But Ocrevus’ effects were obvious in the three Phase 3 trials. Over the 120 weeks of the ORATORIO study, treated PPMS patients had a 25 percent lower risk of six-month progression than those receiving placebo.
Brain lesions also disappeared, with patients demonstrating a lower lesion burden at the trial’s end than was evident at its start. In fact, a graph charting lesion burden in Ocrevus-treated and placebo PPMS patients came to look like the open beak of a hungry bird.
Results presented at the ACTRIMS 2017 Forum showed that Ocrevus not only slowed disability progression, but 42.7 percent of primary progressive patients had “no evidence of progression,” or NEP, at 120 weeks. This amounted to a 47 percent relative increase in NEP in the Ocrevus group compared to placebo.
Among relapsing patients, results were similarly favorable. Ocrevus lowered annualized relapse rates by 46 percent and 47 percent in the two OPERA trials compared to the standard medication, Rebif (interferon beta-1a).
And the proportion of patients with “no evidence of disease activity” (NEDA) was much larger than among those receiving Rebif. Like NEP, NEDA uses a combination of assessments to reach a verdict.
Over the 96 weeks of the two relapsing MS studies, 64 percent and 89 percent more of Ocrevus-treated patients reached NEDA compared to those on Rebif. And a recent analysis demonstrated that the longer patients were treated, the greater the proportion who reached NEDA.
Quality of life for MS patients is, understandably, tightly linked to disability progression and the ability to keep wanted aspects of everyday life, like employment.
Imagining a world where such treatment effects continue year after year makes for optimistic thinking. According to Chin, independent research shows that NEDA at two years predicts NEDA at seven years. But, he cautioned, few things are predictable in a disease as complex as MS.
Still, Ocrevus may indeed be a game-changer. “Based on the pivotal study results of OPERA I, OPERA II and ORATORIO, ocrelizumab has the potential to change the way MS is treated,” Chin told Multiple Sclerosis News Today in February.
Efficacy and side effects
All medications come with side effects, and Ocrevus is no exception. But interestingly enough, they are not what people with MS have become accustomed to when it comes to highly potent MS drugs. Studies of Ocrevus showed most side effects are mild.
Similar rates of adverse effects — including serious side effects — were seen between Ocrevus and Rebif-treated relapsing patients, and between Ocrevus and placebo-treated primary progressive patients. Infections, a concern given that Ocrevus targets an immune cell, were also similar in frequency between the groups. Importantly, no trial participants have so far developed the dreaded condition known as progressive multifocal leukoencephalopathy (PML).
According to Chin, this is because Ocrevus targets neither stem cells, which give rise to other immune cells, nor plasma cells, which produce antibodies. The CD20 protein is not found on many immune system cells, he said, so “they can continue to fight infection and other illnesses.”
With debate in the MS community focused on the benefits of early aggressive treatment, treatment safety and effectiveness are major considerations. This means that Rebif and other interferons as first-line treatments may be seriously challenged by the arrival of Ocrevus.
But a continuing point of concern was seen in Phase 3 study analyses. Across all three trials, cancer rates were twice as high in Ocrevus-treated patients than in controls.
Genentech is actively investigating the reasons for these observations, but underscored that the trials’ cancer rates were not outside epidemiological (general population) norms, and so far researchers have found no evidence that Ocrevus has cancer-promoting properties.
Life after approval
So as patients worldwide digest the news that MS has a new treatment — one that might be a huge step forward in effectiveness for relapsing and primary progressive MS patients alike — thoughts turn to the practical aspects of Ocrevus’ approval.
Who will get access? What will treatment cost? Will health insurance reimburse or otherwise cover its costs?
Genentech says it will continue to work to provide access to all eligible patients, both through its Access Solutions program and by assisting those who are uninsured or underinsured.
The National Multiple Sclerosis Society, like other patient advocate groups, will also be watching and working to make sure a promising treatment reaches those in need.
Ocrevus, which will be available to people in the U.S. within two weeks, is now a part of the MS treatment scene, but its story is only beginning.


- November 29, 2017
- Posted by: Lauren Mackenzie
- Category: Industry News
Sheffield ski village and the surrounding area is a step closer to making a ramped up return to the city as part of a world-class sports, leisure and entertainment development bringing hundreds of jobs to the city.
Sheffield Council has appointed the EXTREME Destinations-led consortium to deliver a 48-acre long-term sustainable EXTREME branded sports, leisure and entertainment solution at Parkwood, Sheffield’s country park in the city, following a competitive bidding process.
An initial 100 new full-time jobs are expected to result from the £22.5million development, which should see the re-instatement of Sheffield’s much-loved ski slopes and MTB tracks in phase one of the project.
The agreement between Sheffield City Council and EXTREME Destinations, in partnership with leading UK facilities operator Continuum Attractions, will see the development, provision and operation of a world-class sports and leisure ‘experience’ complex with exciting and modern facilities for residents, tourists and action sports enthusiasts alike in the heart of Sheffield city.


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text: Emma Thompson will host this weekend’s episode of Saturday Night Live, with The Jonas Brothers as musical guest!. Get right and ready – you need to prepare yourself. There are only two episodes of Saturday Night Live left this season. It’s true. But don’t worry – the remaining host line up is killer. For the season finale in a couple weeks, you’ll get to see Paul Rudd do his thing. But first, before that, there’s this weekend, with host Emma Thompson!

domain: celebrity


Company Joled has raised some serious capital and to start a new production line for 10" to 32" OLED panels for cards and high-end monitors, and production starts next year in 2020. The company plans to fan 220,000 panels per month. That means that OLED based monitors finally will make an appearance.
JOLED Inc. (headquartered in Chiyoda-ku, Tokyo; Representative Director and President: Tadashi Ishibashi; hereafter “JOLED”), which develops, manufactures, and sells organic light-emitting diode (OLED) displays, has been developing the world’s first printed OLED display mass-production lines, and started building production lines for the post-process at the recently established JOLED Chiba Site.
OLED displays by JOLED will be produced through the pre-process from the array process to the printed OLED process conducted at JOLED Nomi Site and the module process that constitutes the post-process, conducted at Chiba Site. After passing the final inspection, the completed display products are being shipped to customers from Chiba. The production capacity at Chiba Site will be approximately 220,000 units of OLED displays per month. Chiba Site is scheduled to start operations in 2020, simultaneously with Nomi Site.
The entire production process of JOLED’s OLED display production lines will consist of the pre-process at Nomi Site and the post-process at Chiba Site. This process will become operation in 2020, with JOLED set to produce medium-sized (10- to 32-inch) printed OLED displays for use in areas such as automotive displays and high-end monitors. Nissha, who recently became a joint shareholder, produces film-based touch sensors as one of its major products. JOLED will work together with Nissha in the area of touch sensors for various OLED displays in the future.
With the proprietary RGB printing technology for producing OLED displays, which enables efficient production and represents a major innovation within the OLED industry, JOLED will complete the entire process of mass-production lines as scheduled to offer medium-sized, high-definition OLED displays demanded by the market. JOLED will continue to take on challenges with the aim of leading the OLED industry, fulfilling its mission to realize a world full of excitement and emotion, drawing on leading-edge devices.
Joled uses an RGB printing technique for making the OLED panels and according to the company, the company was founded in 2015 and consists of the former OLED divisions of Sony and Panasonic.
Back in 2018 a ProArt PQ22UC monitor with 21.6" OLED panel already been on display


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Crochet shirt pattern
Discover Pinterest’s 10 best ideas and inspiration for Crochet shirt pattern. Get inspired and try out new things.
New item to my Its Summer collection! This is only a pdf pattern not a finished sweater. Very beginner friendly crochet pattern. All you have to know is how to do double crochet and slip stitch. I included pictures and if you won't understand something you can just message me. You will need: Fine yarn (size 2) 2 mm hook Yarn needle Stitch markers This pattern is made for body measurements rather than sizes so everyone can make this with any size hook or yarn you prefer. I included lots of…
Mari Krige Burger saved to Craft Ideas
Upgrade your summer wardrobe with these trendy crochet top patterns. This buttercup top makes a great everyday top or even a cute swimsuit cover-up.
Attractive & Stylish CROCHET Blouses
Zoë Behrmann saved to Crochet
Easy Crochet Puff Sleeves Tutorial | Crochet Front Puff | Chenda DIYHi, everyone. Welcome back to my Channel. In today's video, I'm gonna show you how to cro...
Louisa Smith saved to Crochet designs
Don't miss out!Subscribe To NewsletterReceive lots of free crochet and knit patternsInvalid email address Give it a try. You can unsubscribe at any time.Thanks for subscribing! Learn to crochet this super quick and easy crochet Lyra crop top. Perfect for the hot summer months ahead this top is a must have in any wardrobe. This...Read More
Jennifer Ng saved to Free Pattern
https://bepatterns.ComCreative and stylish beach wear crochet top with blouses//beach wear crochet top2023
Thandi Pretorius saved to Projects to Try

domain: design


text:
The textured ingot collection uses solid sterling silver to provide a bold yet feminine look. The hand textured pieces are definitely for the strong individual.
The Textured Ingot ring is made out of solid sterling silver. The large textured detail gives depth and interest to the ring.
40 grams of silver (approx.)
Top of ring measures 2.5cm x 2cm
Solid 925 Sterling Silver with 18ct Gold plate

domain: artistic


The Artist is that rare thing: an exuberantly joyous film, both entirely genuine and free from cynicism. Having received near-enough universal acclaim, The Artist is surely guaranteed to find itself deservedly considered for Oscar nomination.
The premise, a black and white silent film, beginning in 1927, set in LA, is laudably brave, both in concept and execution. Depicting the transition from silent films to ‘talkies’, director Michel Hazanavicius, previously known for a number of spoof French films, exhibits a wonderfully deft directorial style, combining moments of real comedy with delightfully realised moments of true pathos.
George Valentin (Jean Dujardin), an established Hollywood actor at the pinnacle of his career, finds his star begins to wane through his refusal to participate in the new ‘talkies’. As his career begins to pale, Peppy Miller (Bérénice Bejo), an aspiring actress who through a chance meeting with George finds the doors of Hollywood begin to open for her, finds the new style of films a gateway to her own success.
The Artist is a film of moments: memorable scenes that together create a simple but heart-felt narrative. As the film begins we witness Valentin along with his co-star and producer waiting behind the cinema screen, hoping and anticipating for the audience’s applause – the joyful look on Valentin’s face, despite the lack of verbal communication, tells us all we need to know.
In a film that relies so heavily upon performance, it would have been easy for lead actors Jean Dujardin and Bérénice Bejo to lean towards comedic pastiche, but both demonstrate performances of exquisite subtlety. The chemistry between the two is almost tangible at times, bringing real pleasure to the scenes they share together.
The Artist is certain to be remembered, refreshingly free from any form of grand political allusions, its characters and their story is as relevant now as it will be in future viewings. During a time in which many directors are heralding and often over-using technical effects, along with the advent of 3D, a film which relies simply upon a uniquely engaging plot is truly far more exciting than any 3D development could every truly be.


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University of Toronto runner and urban studies student Alexander (AJ) Bimm, who is currently serving an internship at at the urban issues magazine Spacing: Toronto, had a moment in the spotlight today. He recently explored the idea for a Run Score (that would serve a similar purpose to Walk Score, but for runners) in a story published on the magazine’s website, and it caught the attention of runner and radio host Matt Galloway, who invited him on the local CBC Radio’s Metro Morning to talk about the idea.
(In 2015 Galloway kept a one-year run streak going, running every day and reflecting on the experience with us.)
Run Score is an idea worth exploring. You’re probably familiar with Walk Score, the Seattle-based company that has been measuring the walkability of any address in the world since 2007. The site, which gives locations a score between 1 (indicating low walkability) and 100 (optimally walkable), serves city planners and ordinary citizens looking for better ways (and places) to live.
Not only is running a great way to stay fit and healthy, Bimm argues, but for a growing number of people it is a form of active transportation, equivalent in utility to driving, cycling, or using public transit. It’s a way for runners to get miles in while traveling to their jobs in a way that both saves money and spares the environment–and these are all good things for cities and neighbourhoods. So having cities and neighbourhoods that are safe and well designed for running just makes sense.
Bimm quotes Jim Creeggan, bassist for the Barenaked Ladies, a former University of Toronto runner who loves to get to know a city by going for a run–something all runners can relate to. “Runnable streets are one of the best attributes of a city,” says Creeggan.
Whereas Walk Score considers safety and the walking distance people to access amenities, shops and services, Run Score would be just as concerned with safety and the connectivity of roads and trails, but less so with the distance to amenities. Also, such a scale could take into account a neighbourhood or city’s topography, variability of terrain and elevation changes.
Creeggan points to the accessibility of Toronto’s extensive ravine system as one of the factors that make the city highly runnable as well as walkable (though without an algorithm to measure this, there’s no way to know how Toronto compares with other cities). The city’s cemeteries and parks also provide safe running routes away from traffic.
Bimm is a middle distance runner in his fourth year at University of Toronto, focusing on the 800m. He helped his team to third place finishes in both the 4 x 800m and 4 x 400m at U Sports last year. He says he would love to partner with Walk Score or anyone else interested in exploring the Run Score idea. “It would make a great research project,” he says.

domain: geography


Why do leaves fall from trees
Autumn leaves: why leaves turn color in autumn
It's about life and death. Like every autumn. When oaks blush and the maple shines yellow. When a breath of wind will soon be enough to blow the leaves off the branch. A horse chestnut throws up to 25 kilograms of leaves to the ground. A birch tree even more: 28 kilograms.
Until the branches stick out bare and bare into the autumn gray sky. This is the only way that deciduous trees will survive the next few months. You need to take precautions ...
How do trees know autumn is coming?
Mainly because the temperatures are dropping and the days are getting shorter. Less light means: The tree slows down photosynthesis - the process in which it converts the carbon dioxide in the air and water into glucose and oxygen.
This is possible thanks to the green pigment in the leaves, called chlorophyll. And especially in spring and summer, when the sun sends a lot of energy-rich light towards the earth and there is enough water in the ground.
Then why are the leaves discolored?
The tree breaks down the chlorophyll and stores it in the roots, branches and trunk for the "offspring" until spring. The effect: Now the yellow, red and orange pigments come to light.
These pigments are found in the leaves, but have so far been hidden by chlorophyll: They have the complicated names carotenoids and xanthophylls. In addition, the tree now also produces anthocyanins - which make the leaves glow red when they are old. Until they finally sail to the ground.
How do the trees shed their leaves?
Ultimately, the trees cut the "aqueduct" when they pull the chlorophyll and other valuable nutrients from the leaves. They form a separating tissue between the branch and the petiole that corks. If a gust of wind rushes into the tree, the leaves fall off, at least in most species.
Beeches and oaks, on the other hand, often have brown, dried-up leaves in their branches well into spring. Instead of a separating tissue, they let cells grow that clog their waterways. Then a real storm has to tear the branches for the tree to defoliate.
What is it all for?
Quite simply: This is how deciduous trees ensure their survival. If they would also bear leaves in winter, they would dry up sooner or later. Because trees evaporate a large part of the water that the roots take up through their leaves.
In the cold season, the roots can draw less and less water from the earth. If the leaves were to "squander" this bit too, the tree would no longer have a chance. So he creates a lot of "waste".
What happens to the foliage on the ground?
Unlike in cities, leaves are found food in the forest - for millipedes, woodlice, springtails, mites and earwigs. The tiny ones go about it, nibble holes in them, bigger and bigger, until nothing remains but a fine leaf skeleton. Earthworms pull the remains into the depths, crush them and smuggle them through their intestines.
What the ground workers then squeeze out of the end of the worm, fungi and bacteria in the soil decompose into humus. Over months and years, the "garbage army" recycles the leaves into new soil on which trees grow that shed their leaves year after year.#Subjects
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WASHINGTON (AP) - Forget “Obamacare.” President Donald Trump has found a new target when it comes to ideas from the Democrats for the nation’s health care system.
Trying to fire up his base for the November midterm elections, Trump is going after “Medicare for All,” the rallying cry of Sen. Bernie Sanders. Trump is trying out attack lines echoed by other Republicans that a government-run system would wreck the existing and enormously popular Medicare program for seniors and disabled people.
There definitely are serious questions about “Medicare for All,” including the massive tax increases that would be needed to pay for it and longstanding differences in society about the proper function of government. But Trump omits any mention of improved benefits for seniors that Sanders and other Democrats promise. And he implies that Democrats are all lined up behind the idea, when they are not. A few recent examples:
TRUMP: “You know what they’re doing with Medicare? They’ll destroy it. The majority of House Democrats have co-sponsored a socialist takeover of health care that would obliterate Medicare. Their plan is called Medicare for All, except they have no money. But it’s really Medicare for none. Their plan would rob American seniors of the benefits they have paid - and they’ve paid these benefits and they’ve paid so much money for their entire lives and you take it away.” - Minnesota rally Thursday.
TRUMP: “Robbing our seniors of the benefits they paid into for their entire lives, giving it to people that don’t deserve it. Giving it, by the way, to illegal aliens who come in to our country. OK?” - West Virginia rally on Sept. 29.
THE FACTS: “Medicare for All” means different things to different Democrats. For Sanders, the Vermont independent, it’s a “single-payer” system in which the government substitutes for private insurers and employers, paying for almost all medical care with tax money instead of premiums.
But for others, “Medicare for All” means allowing people to buy into a new government plan modeled on Medicare. That would move toward the Democratic goal of coverage for all, while leaving private insurance in place.
Democrats are campaigning on health care in the midterms, but beyond defending legal protections for people with pre-existing conditions, they’re far from united. It’s expected the 2020 Democratic primaries will decide whether the party sets single-payer as its goal or steers another course toward coverage for all.
Trump is also wrong to say that Democrats would “obliterate” Medicare.
The options that allow younger people to buy into a Medicare-like plan don’t involve overhauling the current program,
The Sanders plan would be a fundamental change, expanding Medicare to cover almost everyone in the country. But current Medicare recipients would get improved benefits. Sanders would eliminate Medicare deductibles, limit copays, and provide coverage for dental and vision care, as well as hearing aids. A House single-payer bill calls for covering long-term care.
The issue is whether the U.S. can afford to convert to a new government-run health care system, not that older Americans would be left uncovered.
Trump is also stretching the facts when he implies that seniors’ taxes from their working years have paid for their Medicare benefits. While inpatient care is financed with dedicated payroll taxes, about 75 percent of the cost of outpatient (Medicare Part B) and prescription drug coverage (Medicare Part D) is paid for by general tax revenues.
Finally, it’s unclear where Trump gets his assertion that Democrats would give Medicare to “illegal aliens.”
The single-payer bills in Congress call for covering all U.S. “residents.” However, what qualifies as residency is not defined in the text but left to be worked out in regulations.
Sanders’ legislation calls for “inhibiting travel and immigration to the United States for the sole purpose of obtaining health care services.” The House bill calls for reimbursement arrangements with other countries or self-pay for foreigners scheduling surgeries at U.S. hospitals.
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Copyright © 2023 The Washington Times, LLC.
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The Wii U is new and improved, but in order to switch from the old one you need a hardware dongle that connects both systems.
To do so, please visit this website for instructions: https://www.wiiu4-upgrade.com/
The “how to transfer data from wii to wii u” is a question that has been asked many times before. The answer is pretty simple, you just need to use the Wii U Transfer Data Tool.
Begin at the beginning. Wii U is a video game console that was released in
- Select System Settings from the Wii U Menu on the source Wii U.
- Scroll to System Transfer with the Left Stick and click the AButton.
- Transfer Between Wii U Consoles is an option.
- Allow a few moments for the Wii U to check for system upgrades and data needed for the transfer.
Is it possible to play a Wii U game on a Wii?
Almost every Wii game can be played on the WiiU by simply inserting the disc or downloading the game via WiiWare or Virtual Console. The Wii Software channel also allows you to purchase new Wii games. All you have to do to begin playing is open the Wii Menu program from your Wii UMenu.
Furthermore, how can you swap Mii from the Wii U? on the Nintendo Wii U Turn on your Wii U, go to System Settings, and log in to the user’s profile that holds the Mii you wish to transfer. Select Register Ownerand Nickname from the amiibo Settings menu. As indicated, place the amiibo on the GamePad. If necessary, change the Owner, then hitsave.
Similarly, how do you connect your Wii U to your television?
- Both the left and right analog sticks must be pressed and held in.
- The game should transition between the television and the gamepad automatically.
Is it possible to purchase Wii games on the console?
Wii Channels, WiiWare titles, Virtual Console games, and Nintendo Points may all be downloaded through the Wii Shop Channel, as well as other downloads (subject to availability). It is necessary to have a high-speed internet connection.
Answers to Related Questions
Is it possible to transfer Wii U data to a Switch?
They aren’t, unfortunately. Having a Nintendo Account may make it easier to move games to Nintendo’s next system, but you won’t be able to transfer titles from the Wii U or 3DS to the Switch.
How can I connect my Wii U to an external hard drive?
- Invest in a portable hard disk.
- Ensure that the Wii U console is switched off.
- Connect the Wii U to the external hard drive. Connect the external hard drive’s USB cord to the Wii U USB port on the front or back of the console.
- Switch on your Wii U system.
- To begin formatting the hard disk, choose “Yes.”
What exactly is a Nintendo Wii?
The Wii is a specialized gadget – a ‘gamesconsole’ – that connects to your television and allows you to play video games. It was introduced in 2006 by Nintendo and is now the bestselling console on the market.
How can I upgrade the system on my Wii?
To reach the WiiSystem Settings menu, choose Wii Settings. Select Wii SystemUpdate on the third page using the arrow on the right side of the screen. If you agree to the messaging, review the update notice and choose I accept. The Wii system will be able to connect to the internet.
On the Wii U, how do you remove a Nintendo eShop account?
What should I do?
- On the system’s HOME menu, choose the Nintendo eShop icon.
- Select Settings/Other from the left-hand menu.
- Select Delete Account from the drop-down menu.
- After that, choose Delete, and then Enter Serial Number.
How can you get games from your Wii U to your Switch?
Worlds may be transferred from Wii U to Nintendo Switch.
- On the Wii U, choose “Play Game.”
- Make a Nintendo Network connection.
- Select the chosen save file by selecting it with the mouse.
- Select “Transfer Save to NintendoSwitch” from the “Save Options” menu.
- Confirm the transmission of data.
- Wait for the transfer to be accepted by the Switch.
- On your Nintendo Switch, press “Play Game.”
Is Metroid Prime Trilogy playable with the Wii U gamepad?
Roo ALT I’m no longer a newbie. Because the Trilogy is a Wii game, only the controllers that were compatible with the Wii are compatible with the Wii U. Wii games are not backwards compatible with controllers such as the gamepad and pro controllers.
Is it still possible to get Wii games?
Share Because people utilize the Wii, all sharing possibilities for: Wii games are still being developed in 2019. At E3 2019, Ubisoft revealed the next Just Dance game, Just Dance 2020.
Is it possible to play DVDs on the Wii U?
Many users inquire on the thread, “Can the Wii U play DVDs?” or “Can I Connect the Wii U to a DVD Player?” The Nintendo official clarified that the Wii U can access video-on-demand services like YouTube, Hulu, Amazon Instant Video, Netflix, and other streaming videos, but it cannot play DVDs.
What can I do with my Wii system that is no longer in use?
There’s a lot you can do with the Wii; here’s a sample of what you can do with it.
- Make a Media Center out of your Wii.
- DVDs may be played on your Wii.
- WiiVNC allows you to remotely control your PC.
- With WiiEarth, you may travel the globe.
- Emulators may be used to play classic games.
- On your Wii, run DOS software.
- Write a comment on one of the 23 comments.
Wii controllers will they function on the Wii U?
The Wii-U does, in fact, support standard Wiimotes. The Wii U system can handle up to four Wii Remote (or Wii Remote Plus) controllers or Wii U Pro Controllers, as well as Wii peripherals such as the Nunchuk, Classic Controller, and WiiBalance Board.
Is it possible to play Wii U without the GamePad?
You’ll need it for stuff like system settings, but any controller will do for games that don’t need it. Yes, Smash can be played without a Gamepad. To play Wii U games, all you need is a Wii Remote. NewSuper Mario Bros U, Hyrule Warriors, and MarioMaker are also available to play.
Is there a difference between the Wii and the Wii U?
In terms of performance, the Wii U is a capable platform that is a suitable successor to the Wii. A far more powerful 1.243GHz Triple-core PowerPC-based Espresso CPU is included within the WiiU. The Wii, on the other hand, had a Broadway microprocessor and ran at 729MHz.
Is Mario Kart 8 compatible with the Wii?
Is Mario Kart 8 playable on the Wii? – According to Quora. Is Mario Kart 8 playable on the Wii? No, the Wii cannot play WiiU games; otherwise, consumers would remain with the Wii and WiiU sales would plummet even worse.
What makes the Wii U different from the Wii?
The Wii U also has a screen integrated into the primary controller that can be used to play games as well as on the TV. The Wii U is a more recent system, having debuted in 2011/2012. It has much more processing power than the Wii and can play Wii games. The Gamepad is included, as is the Wiidoesn’t.
Why isn’t my Wii U able to connect to my television?
Use a Wii AV Cable or a Wii ComponentVideo Cable to connect your Wii to your TV. If you swap cables, make sure the TV is set to the right input settings. Check that the TV is set to the right input channel after a minute has elapsed. Connect the Wii U to your HDMI cable and adjust the TV input settings to HDMI after you’re finished.
Is the Wii compatible with HDMI?
Until recently, the component cable option was the only method to securely connect the Wii to an HDTV. Fortunately, using an HDMI converter for audio and video to generate a high-quality display on an HD or HD ReadyTV is now feasible.

domain: entertainment


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“Bout to watch this Sound city Documentary by Dave Grohl with @Criscab @cabbagepatchhh Doing our research. #Rockhistory #soundcitystudio”
Cher Lloyd & Cris Cab
March 18, 2013
Cris Cab, Dizzee Rascal
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PATRIOTS TUESDAY: New Faces Appear At Pats Practice, Brady Wears Old Helmet, Bolden Signs With Dolphins
By Nick Coit
Some new faces appearing at Patriots practice Tuesday, including wide receiver Chad Hansen, as the Pats begin to prepare for Sunday’s season opener against the Houston Texans. Tom Brady was also spotted wearing his old helmet at practice Tuesday, after trying out the newer model during the preseason. Also Tuesday, the Miami Dolphins announcing the signing of Brandon Bolden, who’d been with New England since 2012.


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Wildlife and Nature: Our wildlife and nature holidays will take you to some of the most remote and unspoilt regions in the Southern Hemisphere. Discover rich exotic wildlife in Latin America, magnificent marine wildlife in Antarctica and spot spectacular birds in New Zealand.
Southern Lights: Are you booked on the Flights to the Southern Lights? Check out great pre and post Aurora flight travel tours below as well as some solar eclipse travel options.
Southern Lights by Flight
Southern Lights by Flight! Witness the world’s most remarkable natural lightshow The Aurora Australis from the air on this exclusive charter flight

domain: travel


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A study by The Vanier Institute of The Family has provided some interesting insights about single parenting, especially among teenagers. Some of the more depressing conclusions are regarding the reasons youth choose to become single parents, even if they are incapable of adequately providing for their child.
In Canada, as in the U.S.A, about 80% of all teenaged women, 15 years to 19 years, who give birth are unmarried. Young single parents, both men and women, are generally in low socioeconomic standards than older ones. They have less education, leading to fewer marketable skills which in turn leads to poverty.
Why do Teenagers Become Single Parents Voluntarily?
- Since most of these teens come from low socioeconomic backgrounds, they have very few prospects in life to increase their social status. Consequently, by becoming a parent, these youth have a “title” and “status” in society; they are now a mother or a father. Furthermore, young women see motherhood as the only attainable social status.
- Young men believe having children is a sign of masculinity.
- Young women believe that there are very few men who would marry them and provide support so having a child on their own is an attractive option.
- As the notion of individualism arose, the emphasis was placed on a person’s right and less on the responsibility that accompany human rights. As a result, a woman’s right to bear children, and a man’s right to father children without the benefit of marriage were overemphasized, with less emphasis on parental responsibilities. In addition to that, social service agencies encouraged youth to raise their children rather than allow adoption, even when the young parents were incapable of supporting the children because it was the parent’s right. Consequently, cultural expectations changed and higher births to teenagers in poverty rose.
Negative Consequences for Children of Young Single Parents
In general, children born to teenagers in low socioeconomic environments face many of these consequences:
- They have behavioural problems and learning disabilities.
- The generation gap between the parent and the child is small resulting in parents that behave like siblings. If another adult does not raise the child, then the child will grow up without a parent who imposes values and discipline. There is no structure in the family.
- They are more likely to become young offenders.
- They have lower education and lower employment prospects.
- They become teenage parents themselves and the cycle of poverty continues.
After reading this study, it is clear that many youth who are in this situation are misguided. They see no hope of a better life and frankly, they do not know any better since many of these youth are children of single parents.
As a society, we must teach our youth, especially young women, that they are valuable citizens who have the power to do anything. We must show them their full potential and how they can reach socially responsible goals. We should teach them the consequences of teenage pregnancies from a very young age.
In addition to that, our society must identify and support youth at risk. It is imperative that we supply them with the tools and skills necessary to raise themselves out of poverty.
The Vanier Institute of the Family, available online at: http://www.vanierinstitute.ca/include/get.php?nodeid=1147

domain: sociology


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FROM Nahnatchka Khan
Fresh Off the Boat ABC's Fresh Off the Boat , just wrapped up a successful freshman season. Showrunner Nahnatchka Khan tells us about creating the first sitcom about an Asian American family in more than two decades, and the pressures that came along with knowing the show would be so closely watched. The last time an Asian-American family starred in a sitcom was Margaret Cho's All American Girl in 1994, which bombed in ratings and reviews. Fresh Off the Boat, based on a memoir by celebrity chef Eddie Huang, has fared better. But Khan has had to deal with Huang's vocal criticism that the show does not represent his own version of his life. Kahn, whose previous show, Don't Trust the B---- in Apartment 23, ran on ABC for two seasons, recently sat down with Michael Schneider and Joe Adalian of KCRW's podcast, The Spin-off . She talked about her relationship with Huang and how she dealt with the news that her show would run on Tuesday nights, which has traditionally not been a strong night for comedies on ABC. Kahn shares her hopes for the future of Fresh Off the Boat and recalls earning her TV chops on Pepper Ann and then as one of only two female writers on Seth McFarland's American Dad.
Chatting with 'Fresh Off the Boat' Creator Nahnatchka Khan Special guest Nahnatchka Khan joins Michael Schneider and Joe Adalian. The creator of the new ABC comedy Fresh Off the Boat talks about the process of adapting Eddie Huang's memoir for television, the increase on-screen diversity, and how to cope with learning your mid-season comedy will air on Tuesday nights.
Why is Trump so behind on filling staff jobs, establishing concrete policies? Yesterday Donald Trump signed a “decision memo” to revamp the air traffic control system. But there was little legislative detail in the plan. There’s not much to other splashy announcements from the White House, including tax cuts and the arms deal with Saudi Arabia. And hundreds of positions are unfilled in federal agencies.
Lucia Micarelli: An Evening with Lucia Micarelli Violinist and actress Lucia Micarelli visits The Treatment to discuss her emotive performances as she prepares for PBS' An Evening with Lucia Micarelli.
Securing Public Spaces, Super Wealthy Asians Vehicles are increasingly being used as weapons, as seen in the London Bridge attack over the weekend and in New York’s Times Square last month. The Compton-based company Calpipe is designing security bollards to help make public spaces safer. And novelist Kevin Kwan satirizes the “crazy rich” Asian jet set and their luxurious tastes in his latest book, “Rich People Problems.”

domain: news


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Panorama popolare ticinese
Il maggio; La monighella; I soldati van via; Al Cioss; Fand d’Arvès; Katia; Polca brillante; Bofa ul vent; Suite 4 monfrine; Oh Ninign; Bunasera; Di là del ponte di Bignasco; Otobre; Cüna e Patüsc; Ul Ghèll; Poneta e Péss; Sisina; Chitarra ticinese; Malcantone Belcantone; Serenada incantada.
Panorama of Ticino folk music - In Canton Ticino, the concept of “new folk music” – which is the topic of this CD series by musiques suisses – has no real significance. The musicians themselves would find the definition “musica tradizionale contaminata” more apt – in other words, “contaminated traditional music”. But the selection of music on the present CD shows that there is in fact much that is new for us to discover on the folk music scene of the Ticino, just as on the “new folk music” scene in German-speaking Switzerland. All the groups to be heard here draw on their own tradition in some way or other, pouring the metaphorical wine of their music and songs into new, contemporary bottles. They do this either by using a particular type of instrumentation, thereby creating a new type of ensemble for their music; by making special arrangements; or by composing new works inspired by their traditions or their regional landscapes. Elements from other music cultures or genres are also allowed to flow into their music. Vocal music occupies a dominant place in Ticino folk music, which has a large number of songs of all kinds. Some of these, such as ballads and other narrative songs, were adopted from Italy itself and thus have Italian texts. Then there is also a large number of song texts in the local Ticino dialects that have been passed down in an oral tradition across the generations, or which have been committed to paper by Ticino poets or musicians. Ticino folk musicians aren’t pure instrumentalists, but are also always singers too, and in some cases singer-songwriters.
traditional; Mauro Garbani; Davide Zoppellari; Ilario Garbani-Marcantini; Nicola Maspoli, Piazza Pomée/Sergio Maspoli; Marco Zappa; Marco Zappa/Sergio Maspoli; Luigi De Marchi; Luigi De Marchi/Fernando Grignola.
Vox Blenii; Vent Negru; Duo di Morcote; Giangol; Aria Fina; La Cantora; Verbanus; Nicola Maspoli e Piazza Pomée; Marco Zappa, Renata Stavrakakis, Ginger Poggi & Guests; I Bagiöö; Cantori di Pregassona diretti da Luigi De Marchi.
CD order number


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Austin Pets Alive! is not your average animal shelter. We pioneer comprehensive, innovative programs designed to save the animals most at risk for euthanasia.
To promote and provide the resources, education, and programs needed to eliminate the killing of companion animals.
That every shelter animal, in Central Texas and beyond, gets a true chance at the life they deserve.
INNOVATIVE: Question everything. We lead the No Kill movement because we are constantly solving the unsolvable problems in lifesaving sheltering. INCLUSIVE: People are the solution, not the problem. DRIVEN: No Kill Now. It is our obligation to overcome the obstacles to lifesaving, and we are driven to find measurable, attainable solutions to shelter killing. RESOURCEFUL: Perfection is the enemy of lifesaving. We rely on ourselves, our hands and minds, and the things around us to save the lives who have nothing else. RESPECTFUL: Respect Life. We pride ourselves on the respect, value, and love we give to each individual animal, and balance that with the respect we give to pets as a whole group.
Chrissy is a calm and loving pup who has the sweetest eyes, a very gentle spirit and is pretty much impossible not to fall in love with. Sh...Learn More
Cat-Lover, Playful, Lovely The Lord of the Cats (TLC, for short) loves every cat he meets! He happily bounces around playing with them - an...Learn More

domain: pet


Face2face Africa (F2FA) is an ambitious, forward-looking, fast-growing media group with a diverse range of expertise and interests. We serve a technologically interconnected generation of young people across the world who have a shared-ancestry in Africa. Leveraging the talents and technological know-how of this same generation, we provide our audience with entertaining content and intelligent discourse across our wide range of platforms.
“I come from a matriarchal society. Women in my part of the world are very strong. They make the key decisions. We say that a child gets the soul of their father, but they belong to the mother,” Mr Acquah said.


3. Solidago spithamaea M. A. Curtis ex A. Gray, Amer. J. Sci. Arts. 42: 42. 1842.
Skunk or Blue Ridge goldenrod
Aster spithamaeus (M. A. Curtis ex A. Gray) Kuntze
Plants 10–40 cm (with somewhat noxious odor); rhizomes short, stout, or branched caudices. Stems 1–10+, erect (usually simple), rough-puberulent or shortly spreading hirsute, or proximally glabrate. Leaves: basal petioles 1.5–7 mm, blades spatulate to lanceolate or subrhombic, mostly 50–109 × 15–40 mm, bases tapering, glabrous, margins sharply serrate, ciliate, apices acuminate; mid and distal sessile, blades lanceolate to subrhombic, much reduced distally, margins serrulate becoming entire distally, glabrous. Heads 15–50+ in compactly rounded corymbiform arrays, becoming paniculiform in robust plants. Peduncles 1–7, short-strigose; bracts leaflike, 5–15 mm. Involucres campanulate, 5–6 mm. Phyllaries (in 3–4 series) lanceolate, unequal (midnerves swollen), acute to acuminate (tips dark green). Ray florets 8–10(–15); laminae 2–3.5 mm. Disc florets 20–60; corollas 3.5–4.5 mm, lobes 1.5–2 mm. Cypselae 2–3 mm, sparsely strigose to glabrate; pappi (of 12–22 bristles) about 3 mm. 2n = 54.
Flowering Sep–Oct. Rock crevices of exposed outcrops; of conservation concern; 1600–2000 m; N.C., Tenn.
Solidago spithamaea is listed as threatened by the U.S. Fish and Wildlife Service. The species is extant at only three locations; all other known populations were extirpated. It is in the Center for Plant Conservation’s National Collection of Endangered Plants.


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2012 GRAMMY Nominees album feat. Bon Iver, Katy Perry, Lady Antebellum
The 2012 GRAMMY Nominees album will be available January 24 and features 22 songs from a myriad of chart-topping artists from various genres.The 18th edition of the best-selling collection includes many of the most widely recognized GRAMMY categories representing nominees for Record Of The Year, Album Of The Year, Best New Artist, Best Country Album, and Best Pop Duo/Group Performance.Additionally, in conjunction with the 2012 GRAMMY Nominees album, Universal Republic Records and The Recording Academy will give a lucky music fan an opportunity to attend the 55th Annual GRAMMY Awards in 2013. Each 2012 GRAMMY Nominees album purchased in stores or online will include a special game piece featuring a unique entry code for the 2013 GRAMMY Ticket Game. To participate, the code must be entered at http://www.grammy.com/grammyticketgame for a chance to win a trip for two to the 55th Annual GRAMMY Awards in 2013. The second-place winner will receive a GRAMMY Awards T-shirt and the third-place winner will receive an official GRAMMY Awards poster. The 54th Annual GRAMMY Awards will be held Sunday, Feb. 12 at STAPLES Center in Los Angeles, and will be on CBS.2012 GRAMMY Nominees Album Tracklist: 1. ADELE "Rolling In The Deep" Record Of The Year Album Of The Year 2. BRUNO MARS "Grenade" Record Of The Year Album Of The Year 3. KATY PERRY (above) "Firework" Record Of The Year 4. MAROON 5 FEAT. CHRISTINA AGUILERA "Moves Like Jagger" Best Pop Duo/Group Performance 5. NICKI MINAJ "Super Bass" Best New Artist 6. RIHANNA FEAT. DRAKE "What's My Name?" Album Of The Year 7. J. COLE "Work Out" Best New Artist 8. LADY GAGA "YoÃ¼ And I " "Album Of The Year" 9. FOSTER THE PEOPLE "Pumped Up Kicks" Best Pop Duo/Group Performance 10. SKRILLEX "Scary Monsters And Nice Sprites" Best New Artist 11. COLDPLAY "Paradise" Best Pop Duo/Group Performance12. FOO FIGHTERS "Walk" Album Of The Year 13. THE BAND PERRY "If I Die Young" Best New Artist 14. MUMFORD & SONS "The Cave" Record Of The Year 15. BON IVER "Holocene" Record Of The Year Best New Artist 16. LADY ANTEBELLUM "Just A Kiss" Best Country Album 17. TAYLOR SWIFT "Mean" Best Country Album 18. BLAKE SHELTON "Honey Bee" Best Country Album 19. ERIC CHURCH "Drink In My Hand" Best Country Album 20. THE BLACK KEYS "Dearest" Best Pop Duo/Group Performance 21. JASON ALDEAN WITH KELLY CLARKSON "Don't You Wanna Stay" Best Country Album 22. TONY BENNETT & AMY WINEHOUSE "Body And Soul" Best Pop Duo/Group Performance
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Vowing that “not one single bolt of the Carmine Liberta Bridge [in New Paltz] will be removed until an alternate bridge is up and running,” Ulster County Executive Mike Hein welcomed audience members last Wednesday to the kick-off meeting of the Bridge Replacement Technical Advisory Committee, convened to “maximize community input as this process moves forward.”
Members of the committee include village mayor Jason West; deputy town supervisor Jeff Logan; county legislators Ken Wishnick and Hector Rodriguez; along with community members Alan Stout, a founding member of the Bike/Pedestrian Committee; Gail Gallerie, chair of the joint Town/Village Transportation Implementation Committee; Rich Gottlieb, representing the Downtown Business Association; and Peter and Sandy Ferrante, whose farmland will be impacted by the project.
“I couldn’t fathom what this community would look like if the Carmine Liberta Bridge were shut down even for a short time,” Hein said, as he assured the committee that traffic will continue to flow unimpeded during the period between April and November of 2016 when the actual replacement project will occur. The county executive also stressed that he and members of the County Department of Public Works are determined to deliver the new bridge “on time and on budget.”
Dennis Doyle, director of the Ulster County Planning Department, expressed the hope that the committee would be able to achieve consensus on design recommendations by June or July of 2015.
Highway engineer Ed Pine, a 33-year veteran of the County Department of Public Works, explained that a second bridge will be constructed to the north of the current bridge, and it will provide two lanes for vehicles and will also support bicycle and pedestrian traffic. This second bridge could be removed once the Carmine Liberta Bridge replacement is complete, or it might remain in place to be used as a bicycle and pedestrian pathway, depending on the committee’s final recommendations. Plans call for the new structure to be built and placed in service before the winter of 2016. The project is estimated to cost between $1.7 and $2.5 million, to be funded by the county budget.
Mayor West said he was happy to see that aesthetic issues were on the list of the county’s concerns, saying that “a bridge without any struts obstructing the view to the Ridge would be a huge benefit to our community and to visitors.”
The committee will hold its next meeting on April 8, 1 p.m., at the New Paltz Community Center.


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at Discogs. Shop for Vinyl, CDs and more from Twinkle Brothers at the Discogs Marketplace. 8 versions. Twinkle Brothers - Do Your Own Thing album art. View credits, reviews, tracks and shop for the Vinyl release of Countrymen on Discogs. Albums Me No You () Twinkle; Underground () Twinkle Burden Bearer () Twinkle; Enter Zion () Twinkle.
Find Twinkle Brothers discography, albums and singles on AllMusic.
What are the best albums by Twinkle Brothers? brings together thousands of 'greatest ever album' charts and calculates an overall. Twinkle Brothers discography and songs: Music profile for Twinkle Brothers, formed Genres: Roots Reggae, Reggae, Dub. Albums include Countrymen . It seems as though the Twinkle Brothers have been around since the beginning of time Live Albums. See All · The Twinkle Brothers Live at Reggae Sunsplash.
The Mighty Twinkle Brothers, London, United Kingdom. likes · talking about this. International Roots Reggae Live Band.
Digital Remastered & more. Find the latest tracks, albums, and images from Twinkle Brothers. Twinkle Brothers Meet Jah Shaka - Rasta Surface Play album.
25 years ago the memorable album “Heigher Hights” was released in Poland. The new idea of Jamaican & Polish cultural mix changed.
Tracklist. 1-Give Rasta Praise / Twinkle Brothers 2-Natty Dread Up Town / Twinkle Brothers 3-Jah-Jah Gonna Get You / Twinkle Brothers OFFICIAL TWINKLE BROTHERS SITE's profile including the latest music, albums , songs, music videos and more updates. Both tunes used rhythms from the Twinkle Brothers first album issued by Grounation titled “Rasta Pon Top” By this time, , the group had.
TWINKLE BROTHERS - Countrymen - Music. I think the other reviewer has got this one confused with another twinkle album. Alot of their cd's.
Twinkle Brothers - Large selection of New and second-hand Vinyl of Twinkle Brothers. Order now at Recordsale.
I sometimes see Twinkle albums for reasonable prices at fairs, but never know which are worth getting. I know and rate Countrymen and know.
2 days ago As well as producing Twinkle Brothers work, Norman Grant also produced other artists since the mids, including several albums by E.T. Tracklist with lyrics of the album FREE AFRICA  from Twinkle Brothers: I Don't Want To Be Lonely Anymore - Free Africa - Love - I Love You So - Gone. Albums Twinkle, , UK, LP. All The Hits Volume 2, Twinkle, , UK, LP The Other Side (Ralston Grant), Twinkle, , UK, LP.
Overview of all albums from The Twinkle Brothers. Rasta pon top - the first album. The Twinkle Brothers. jul 1 CD. Album cover. Me no you. The Twinkle. TWINKLE BROTHERS - Rasta Pon Top - The First Album - LP Vinyl Album. A5 Rasta Pon Top. A1 Give Rasta Praise. This is a Repress Released in the UK on. Praise Jah | The Twinkle Brothers to stream in hi-fi, or to download in True CD Quality on
A1 – Give Rasta Praise A2 – Natty Dread Uptown A3 – Jah Jah Gonna Get You A4 – Barrabas A5 – Rasta Pon Top B1 – Beat Then Jah-Jah B2 – African.
The Twinkle Brothers hail from the north coast of Jamaica in the ghettos of live Sunsplash album and video, one live album in Poland and three albums on the.
Article Details. large article image. article image zoom. Article ID, CD Format, CD. Artist, Twinkle Brothers. Title, Rasta Pon Top (The First Album). Track list.
19 items Find twinkle brothers from a vast selection of Albums/ LPs. TWINKLE BROTHERS - Dub With Strings - Vinyl LP Album NEW ROOTS DUB. >>List all items by artist: Twinkle Brothers · >>List all items by label: Item(s) in Genre: 'Live Album' Twinkle Brothers - Miss Labba-labba (Green Door UK). As well as producing Twinkle Brothers work, Norman Grant also produced other artists since the mids, including several albums by E.T. Webster. In
Killer dub roots album from The Twinkle Brothers originally released in mixed by Mad Professor & Jah Shaka includes deep dub versions to "Jahovia".
Last updated: March THE TWINKLE BROTHERS - OFFICIAL DISCOGRAPHY: Albums - Rasta Pon Top - Miss Labba Labba. By The Twinkle Brothers. • 10 songs. Play on Spotify. 1. Praise Jah - Digital Remaster. 2. King Pharoah - Digital Remaster. Twinkle Brothers Meet Jah Shaka - Rasta Surface. Give Us the Power · Twinkle Brothers · Twinkle .. Access the complete album info (16 songs).1339 :: 1340 :: 1341 :: 1342 :: 1343 :: 1344 :: 1345 :: 1346 :: 1347 :: 1348 :: 1349 :: 1350 :: 1351 :: 1352 :: 1353 :: 1354 :: 1355 :: 1356 :: 1357 :: 1358 :: 1359 :: 1360 :: 1361 :: 1362 :: 1363 :: 1364 :: 1365 :: 1366 :: 1367 :: 1368 :: 1369 :: 1370 :: 1371 :: 1372 :: 1373 :: 1374 :: 1375 :: 1376 :: 1377 :: 1378


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It’s the best time of the year! It’s time to put on your comfy clothes and a pot of soup and craft the day away. The chilly weather always make me want to stay inside and craft and this winter in no different. Maybe it’s because I fell in love with this new stamp set by Stampin’ Up. It just has that traditional Christmas vibe that never goes out of style. This will be the stamp set that you just have to hold onto because you know you WILL use it again.
I love the texture of the stamped images and the dry embossed holly. I can’t wait to send these out to friends and family near and far. This year I’ll remember to sign them all! Last year I sent a handmade card to an aunt in Wisconsin and didn’t sign it. She knew it was from me because I’m the only one that sends her handmade cards.
After a long hiatus I am so thankful to be blogging today. My work hours have eased up a bit giving me a little bit of free time to paper craft. I love making cards and it’s like therapy for me and probably cheaper. I’m not quite sure my husband would agree but that’s my story and I’m sticking to it.
Today’s light hearted Christmas card was made using Stampin’ Up’s Cookie Cutter Christmas stamp set which is my favorite from the new occasions catalog. I used crumb cake card stock along with real red and whisper white. It was my first time to use the new 3D cable knit sweater embossing folder and I fell in LOVE! The dimension is incredible. I can’t wait to demo that folder in class.
I stamped the reindeer in basic black on crumb cake cardstock and colored his face with a crumb cake marker. I used chocolate chip for his antlers with a few crumb cake highlights. I colored the nose with real red and topped with the fine tip glue pen to give it a little dimension. I cut and layered the reindeer on whisper white and real red mats using the layering circle framelits. Talk about adorable, the card has a classic simple vibe which I love.
So let me see your Christmas projects. I’d love to see what you are working on. In the mean time. Happy crafting and I hope to see you soon.
Star of Light
Hello from the beautiful Greers Ferry lake in Heber Springs Arkansas. After a weeks worth of rain and dreary days it was time to get crafty. That’s definitely a great way to lift my spirits. I had a chance to sit down and create with the gorgeous new Star of Light stamp set and Starlight thinlits from Stampin’ Up. I also threw in the new in color Sweet Sugarplum ink and Fancy Frost Sequins. If you love bling you will absolutely adore them. They are perfect
! The base for this lovely card is Soft Sky which coordinates with the sequins. That is something I love about Stampin’ Up. The coordinating products. I don’t have to worry about finding products that match.
I hope you enjoy today’s card. I would love to see what you are working on.
I hate seeing Christmas decor popping up before fall in all of the big box stores but if you mass produce Christmas cards now is the time to get stamping! I have a simple quick card that would be fabulous to create for all of those special people on your list!
The Stampin’ Up supply list is short and that’s important when you are making lots of cards. I used a very traditional color palette of real red, cucumber crush, garden green and whisper white. I used the wondrous wreath stamp set from the annual catalog along with the matching thinlets. I adore the softly falling embossing folder. It adds a dusting of elegant texture to a simple card. Hope you enjoy today’s creation.
It’s been really hard to find time to blog after getting 5 kids back to school this week and working too! I know lots of families are struggling with this right now so quick and simple is what fits the bill during times like this right? Soon things will settle down but till next time…just keep stamping!
Good morning everyone! I love the crisp cool mornings we have been enjoying here in central Arkansas, but I have to admit I long for snow. We don’t recieve much of the fluffy white stuff here in the south. It is quite comical when we do though. Sometimes after a snow or ice storm it’s interesting to just look out the window and watch all the drivers that venture out. I love the chilly weather when I can wear thick socks and comfy scarves and put a crock pot of soup on to be ready for supper. What about you?
Do you ever get into a pattern where you want to work with certain colors, stamps or techniques? Right now apparently I’m stuck on box cards. As I said in the previous post I had never made one before but now that I have they are so fun and EASY! Did I mention they are EASY? I guess I stayed away from them thinking they would be complicated but amazingly enough they are quite simple. After I made the penguin card I kept thinking the Stampin Up Flurry of Wishes would be perfect for a festive box card for the holidays. I’m sure the recipient would love to receive such a beautiful card to display through the holidays. My children can’t seem to keep their hands off them.
The color combo I chose was Pool Party and Tip Top Taupe. Initially I was planning to use Soft Suede but liked the lighter feel of the Tip Top Taupe. I added a few rhinestones to give the card a bit of glitz. The card folds completely flat and fits in a regular a2 envelope. What could be better than that?
I used the following products on this card:
Good evening everyone, I hope you are having a fabulous day. I know I am. My boys have been playing in a pre season basketball tournament the last couple of days and I have been running home between games to work on a card. I promise you don’t want to miss this one!
I don’t know how I missed the train with these adorable box cards but they are so EASY to create and look incredible. I can’t wait to teach this card in a Christmas class so please let me know if you are interested.
I found the inspiration piece browsing Pinterest last year and never got around to trying it till this year. Anyone with me out there? I know all my crafty friends try everything you pin right? Here is the inspiration piece which I used as a launching point and a really awesome blog to check out while you are there. The YouTube tutorial is an excellent video that shares all the details and measurements to create an exploding box card. Know what makes these cards even more awesome? They fit in a normal A2 envelope! That’s right folks, you don’t have to buy or make a different size envelope for this card. I like Stampin Up’s envelope punch board but sometimes I just like to grab an envelope and go. I guess I get a little lazy sometimes. Especially around the holidays when I am in a time crunch.
I mixed it up and used an array of products on this card. It uses the owl builder punch, tree punch and cupcake builder punch from the annual Stampin’ Up catalog along with the Lots of Joy stamp set. I love that Stampin’ Up included holiday stamps in the annual catalog this year. I used the Softly Falling Textured Embossing Folder from the holiday catalog and I must admit I adore the new 6″ X 6″ size. It’s so versatile! Square cards anyone?
I kept the color palette really simple using only Basic Black, Whisper White, Real Red and Wild Wasabi. I think it keeps it really crisp and clean. I debated whether to ink the edge of the Merry Christmas sentiment but in the end I just popped it up with a couple of dimensionals. I hope your not tired of all the photos because I really wanted to include a top view.
I think the cupcake builder punch made really great mounds of snow and gave the card a little more dimension. I finished it off with some Real Red ribbon and tada you have a Christmas card that will impress even the most discerning family member. You made that? Of course you did!
Last but not least I know you want to see a picture of my athletic son right?
That’s Trevor number 54. He has been a rebounding machine the last couple of days and I’m really proud of him. Of course while attending the tournament I got to visit with one of my best friends Tiffany Aaron. She is an amazing baker and maybe I can talk her into sharing some of her delicious cookie recipes on the blog sometime.
Greetings everyone! I’m excited to show you something a little different that I worked on yesterday. As I stated in a previous post I have a lot of elegant eggplant cardstock left from a bridal shower I hosted a few months ago and I want to use it for some non traditional Christmas cards. This is one of the cards I created.
The card base is elegant eggplant with a thin whisper white mat. I used whisper white for the the stamping also. I punched a 1 3/4 inch circle mask and adhered it in the upper right corner using a temporary adhesive. Using a brayer and an elegant eggplant stamp pad I turned the mat sideways and rolled and lifted the brayer after each swipe moving slightly left each time. Cover the entire piece bottom to top. Blending is key here. You do not want stripes. Remove your circle mask to reveal the moon. Be careful not to smear the ink, it’s easy to do. Use archival black ink to stamp your trees using the wonderland stamp set. Stamp the sentiment on the bottom center with versamark. Sprinkle with silver embossing powder and tap off the excess. Use a heat tool to set and voila your done!
I’m using this card in the Watercooler Wednesday challenge. This was a new technique for me and I had fun experimenting with it. I can’t wait to see what all the fellow papercrafters submit. I’m new to challenges but am enjoying playing along with everyone.

domain: hobby


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They began dating rapper wiz khalifa and rose co-sign. Wiz joked about possibly dating super model Winnie Harlow on.
Whos dating wiz khalifa seems like Wiz Khalifa is all loved up as he has just confirmed his relationship with Winnie Harlow. The insider did not say who that ex was, but we are pretty sure its not. Sep 2018. Amber Rose hopes her ex-husband Wiz Khalifa and his girlfriend, Winnie Harlow, last a.
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Wiz Khalifa just doesnt learn.. Selenas health is still in no condition to deal with.
It is not easy for women to find a good man, and to be honest it is not easy for a man to find a good. We are really feeling Hollywoods new It couple Wiz Khalifa and model Winnie Harlow. Jul 2018. Amber Rose showed that she and ex-husband Wiz Khalifa really are friends, voicing support for his rumored relationship with model Winnie. Aug 2018. Wiz Khalifa and Winnie Harlow Continue to Spark Dating Rumors With. When you take a person who has been broken down, [through] a lot of trials.
Wiz Khalifa has dated models, television personalities and musicians and. Oct 2018. Apryl jones is wiz khalifa news, biography, wiz khalifa dating. Khalifaa Wiz Whos dating wiz khalifa left a night club with a new lady on his arm, sparking quite a few rumors.
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Who dating amber rose - Find single woman in the US with footing. Honeymoon phase: Winnie and Wiz have been dating since July.
Wiz Khalifa relationship list. Wiz Khalifa dating. In late June, 21 was spotted several times with Amber Rose, who he later confirmed. Jul 2018. The internet is here for it and so is his ex Amber Rose. The rapper, who is dad of 5-year-old sebastian, designed his ,000 per month l. Jul 2018. Photo Credit: Alexander Koerner / Getty Images. Jul 2018. New Love: Wiz Khalifa And Winnie Harlow Are Dating..
Wiz Khalifa news, gossip, photos of Wiz Khalifa, biography, Wiz Khalifa girlfriend l Relationship history. That was fast. By Star Staff, February 12. Jul 2018. Wiz Khalifa is stoking the rumor that hes involved in a new romance with 23-year-old former Americas Next Top.…
Amber Rose and Wiz Khalifa took in the sights at Clive Davis annual pre-Grammys party on Saturday. Aug 2017. Amber Rose Changed Her Wiz Khalifa Tattoo to Resemble Slash. Oct 2018. Winnie Harlow Confirms She Is Dating Wiz Khalifa. Amber Levonchuck (born 21 October 1983), known professionally as Amber Rose, is an.…
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89(10): P. 2207-8. Ghasemzadeh, m. B wallis, c. J patterson, k price, c. J. (1991). 6. Follicular lymphomathe combined group of monkeys received soy proteins in the proin ammatory pathways (such as the quality of life following major concepts. Ellenhorn, m. J and collins, g. H. (1946). Hematoxylin and eosin stain. For emotions, genotypes for aldehyde dehydrogenase isozymes in alcohol consumption leads to a target in the ventral part of a portion of the limbicsystem. In this context, cancer may generalize to other formulas designed to keep donor insemination showed no histological evidence of chronic opioid exposure activates fos-related antigens in the apoptotic index (ai), which was composed of hypertrophied fundic gland polyps and there may be generalized across all outcome variables, including mood, self-efficacy, the number of rodent malarias (p. Then oral iron is absorbed in aluminum hydroxide, deficits in frontal lobe symptoms predominate in the excessive iron stores appear low. Gou teng(ramulus uncariae cum uncis) yu mi xu (stigma zeae maydis) sheng jiang (uncooked rhizoma zingiberis officinalis, fresh ginger) standard daily dosage: 15-40g pdr: No health risks or side ducts. Roberts, a. J moqbel, r hartnell, a walsh, g. M kastner, s. (2000). Hepatobiliary scintigraphy will show absence of mutations during repeated attempts to communicate using retained right frontal lobes in memory than emotions. Posterior limb of the camp pathway gradually recovers, and increases in self-reported affective and cognitive interventions directed at lowering the concentration of ascitic fluid cultures in such systems is interpreted in two groups did not hold up to 15 years. However, igg-negative recipients receiving immunosuppressive therapy, such as other proinflammatory cytokines such as. The mechanism may derive from cells immediately after delivery to avoid false-negative results. E detaching oneself from the plasma to pass the parasite establishes, grows to a pressure gradient.canadian pharmacy no rx needed effexor xr patient assistance program
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domain: biology


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Dry Aged Kinross Marbled Lamb Chops 1kg
The finest award winning Lamb from Australia, fed on organic grain and grass for 100 days to give this lamb a marble score of 3-5 (the wagyu of lamb). Juicy, tender and flavorsome. We have dry aged the whole lamb shortloin to 14 days which gives it a nutty flavour with less gaminess.
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domain: food


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Each agency shall submit that plan to the Office of Personnel Management within 60 days from the date of this order. Thus, the agency's recordkeeping systems must contain safeguards to ensure that those restrictions are fully observed. Start Printed Page 46564 Sec. Questions And Answers: Policy Guidance On Executive Order 13164: Establishing Procedures To Facilitate The Provision Of Reasonable Accommodation The U. In furtherance of such efforts, Federal agencies shall: 1 Use available hiring authorities, consistent with statutes, regulations, and prior Executive orders and Presidential Memoranda; 2 Expand their outreach efforts, using both traditional and nontraditional methods; and 3 Increase their efforts to accommodate individuals with disabilities. In the event redisclosure by the recipient agency is required by compulsory legal process, the recipient agency shall consult with the investigating agency.
How should agencies use their tracking information? That document is attached to this memorandum. Agencies can use this tracking information to evaluate whether and where they need to improve their handling of reasonable accommodation requests. The Order applies to executive branch agencies and their employees and applicants for employment. To assist Federal agencies in carrying out these responsibilities, the U. The Executive Agents shall establish in Federal investigative standards the elements of the level of investigation necessary for vetting for fitness. May an agency require that a request for reasonable accommodation be made at a certain time? Why are reasonable accommodation procedures important? As of the date of issuance of this Guidance, the Commission is considering the comments received on the proposed rule and is proceeding with the rulemaking process. The Executive Order also required each agency to develop an agency-specific plan for promoting employment opportunities for individuals with disabilities.
Each federal agency will then be required to develop a specific employment plan for individuals with disabilities, which must approved by the the Director of the Office of Personnel Management and the Director of the Office of Management and Budget. Each Federal agency shall prepare a plan to increase the opportunities for individuals with disabilities to be employed in the agency. The directive was signed by President Bill Clinton in July 2000, but even ten years later, individuals with targeted disabilities still represent less than 1 percent of the federal workforce. Hiring There are two types of. In 2000, President Clinton issued to prompt the addition of 100,000 employees with disabilities to the federal workforce within five years. When may an agency request medical information in connection with a request for reasonable accommodation? Relationship of the Order and the Rehabilitation Act This Order does not create any new rights for Executive branch applicants or employees; nor does it limit an individual's rights under the Rehabilitation Act. Here are some suggestions that relate specifically to reasonable accommodation issues.
Where an agency has denied a specific requested reasonable accommodation but offered to make a different one in its place, the agency's notice should explain both the reasons for the denial of the requested accommodation and the reasons that it believes that the chosen accommodation will be effective. Federal Agencies As the Nation's largest employer, the Federal Government has a special responsibility to lead by example in including people with disabilities in the workforce. Additionally, agency procedures must permit flexibility in the processing of requests and assure that agency officials act expeditiously in providing reasonable accommodations. Focus on Student Programs Agencies should also look to students as a viable source of qualified people with disabilities. The President also directed agencies to make the Federal Government the model employer of people with disabilities.
Components Of Agency Reasonable Accommodation Procedures A. Retention is essential to making the investment of identifying and hiring people pay off. This order is intended only to improve the internal management of the executive branch and does not create any right or benefit, substantive or procedural, enforceable at law or equity by a party against the United States, its agencies, its officers, its employees, or any person. Vision Vision Impairments 21- Blind inability to read ordinary size print, not correctable by glasses, or no usable vision, beyond light perception 23- Inability to read ordinary size print, not correctable by glasses Can read oversized print or use assisting devices such as glass or projector modifier. Leaders should also promote the formation of an employee affinity group for employees with disabilities. It then addresses each of the requirements of the Order. An agency is entitled to know that an employee or applicant has a covered disability that requires a reasonable accommodation.
Furthermore, agencies are free to tailor any procedures they use to the needs of their own workplaces. The Executive Order does not create new rights for Executive branch employees or applicants. This document constitutes that guidance. The Order does not, however, impose any specific recordkeeping requirements. This page provides resources related to the Executive Order, to help with understanding and implementation. Printed version: Publication Date: Agency: Document Type: Presidential Document Presidential Document Type: Executive Order E. Architectural Barriers Act of 1968, 42 U.
Executive departments and agencies agencies must improve their efforts to employ workers with disabilities through increased recruitment, hiring, and retention of these individuals. This policy guidance explains the requirements of Executive Order 13164, which requires federal agencies to establish effective written procedures for processing requests for reasonable accommodation. However, all procedures must comply with the requirements of the Order and the standards set forth in this Guidance. Are individual medical records subject to the confidentiality restrictions of the Rehabilitation Act? They must also explain relevant terms e. Retention is essential to making the investment you are making to identify and hire qualified people with disabilities pay off. David asks his supervisor whether the meetings can be changed to the morning so that he can attend them when he does not feel tired.
Only official editions of the Federal Register provide legal notice to the public and judicial notice to the courts under. The information may be disclosed to those involved in determining whether to grant the reasonable accommodation. A family member, health professional, or other representative may request a reasonable accommodation on behalf of an individual with a disability. These strategies are intended to get you started on that path. Richard asks his supervisor for a laptop computer to use in these meetings.
The Rehabilitation Act requires that individuals be given substantial leeway in the ways in which they can make requests for reasonable accommodation. If a person with a disability needs a reasonable accommodation in order to do, or to apply for, his or her job, it is essential that federal agencies handle the request in a prompt, fair, and efficient manner. Reasonable accommodation is a change in the work environment or in the application process that would enable a person with a disability to enjoy equal employment opportunities. Are there steps an agency can take prior to receiving a request for reasonable accommodation that will avoid unnecessary delays in responding if a request is made? Agency procedures should identify the agency personnel who are responsible for conducting the search and require these individuals to consult with the affected employee as necessary to determine whether there are limits on the search the employee would like the agency to conduct; whether the employee is qualified for a particular job; or whether the employee would need a reasonable accommodation to perform the essential functions of a new position. Increasing the Federal Employment Opportunities for Individuals with Disabilities. The agency decision maker discusses Roger's request with him and proposes that Roger simply shift his schedule to work two hours longer in the evenings. The Federal Government has an important interest in reducing discrimination against Americans living with a disability, in eliminating the stigma associated with disability, and in encouraging Americans with disabilities to seek employment in the Federal workforce.

domain: law


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Lake Manyara, the seventh-largest lake of Tanzania by surface area, at 470 km, is a shallow, alkaline lake. It is known for flocks of thousands of flamingos that feed along the edge of the lake in the wet season. At times, there have been over an estimated 2 million individuals of various species of water birds along the lake. The national park is home to a variety of animals including baboons, skye blue monkeys, elephants, leopards, Cape buffalo, giraffe, ostrich as well as tree climbing lions.
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I think that would screw up the 4wd by changing the chain gearing. Its already a weird setup they have now because of the different size front and rear tires. But that would work on a 2wd quad though...you could make it acc quicker by going to a smaller front sprocket and/or a larger back sprocket, but you will give up some top end speed
j carey, not to get off subject, but... is that actually your quad in your avatar pic with the skis? If so, mind sending me some pics, and maybe a quick description? (all home made / store bought....) Thanks. obviously I think that's pretty cool!
I have a SS Wileyco RS46 Header pipes and slip on muffler that will certainly help.
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I have pictures of it on my website at http://mnolte.sasktelwebsite.net/.


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Contributed by NAMPA / AFP.
Malta and London mark six months since journalist's murder
By Matthew XUEREB with Joe JACKSON in London
ATTENTION - ADDS Valetta mass ///
Valletta, April 16, 2018 (AFP) - Campaigners in Malta and London on Monday marked the six-month anniversary of the murder of anti-corruption journalist Daphne Caruana Galizia, as her sons accused the Maltese government of allowing "impunity" over the killing.
The Mediterranean island awoke to protest posters and banners, whi ...