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Hello, I am a trustworthy and caring Mum of two with a furbaby of our own. Buddy is a cavalier and just loves to have friend over to visit. I am lucky to work from home, so am available all day to care for your dog and look after them like one of my own. Daily walks will be provided and they will have run of the house, including the secure garden and on the furniture of course lol! For overnight visits they will sleep inside with us, as well as having the run of our house and secured garden in the day. I have owned dogs all my life and look forward to meeting yours. Other pets also accommodated on request. ...
Children at home
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Reviews & Testimonials
Pet Day Care - Mar 15, 2021
Thanks Helen! Alfie always loves visiting you and Buddy :)…
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Thanks so much Helen! Alfie seemed to love his stay with you and enjoyed playing with your Buddy :)…
Pet Day Care - Dec 12, 2020
Thank you so much Helen. Amazing care of Teddy. He’s sleeping soundly after a fun day …
Pet Hosting - Dec 6, 2020
Thanks Helen for taking such good care of Daisy. …

domain: pet


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Tuscan tuna toasts
- 1 large red capsicum
- 425g can tuna in spring water, drained, flaked
- 400g mixed grape tomatoes, quartered
- ½ medium-sized red onion, thinly sliced
- 1 tablespoon capers, drained
- ½ cup fresh basil, plus extra, to serve
- 4 tablespoons balsamic dressing (made with 2 parts balsamic vinegar : 1 part olive oil)
- 8 slices wholegrain sourdough
- 4 cups rocketarugulaX
1 Spray a grill pan with oil and set over a medium–high heat. Cook capsicum, skin-side down, for 8-10 minutes or until skin is black and blistered. Place capsicum in a zip-lock bag and seal. Set aside for 15 minutes.
2 Meanwhile, place remaining ingredients, except sourdough and half the dressing, in a large bowl. Toss lightly to combine. Set tuna mixture aside for 10 minutes.
3 Set the same grill pan over a medium–high heat. Add slices of sourdough and cook, turning, for 5 minutes or until toasted.
4 Peel or rub skin from reserved capsicum. Discard skin. Slice in strips and add to reserved tuna mixture. Toss to combine.
5 Divide toast among plates, top with tuna mixture and extra basil. Toss rocket with remaining dressing and serve to the side.
Make it gluten free: Use gluten-free bread.
Nutrition Info (per serve)
Total fat 9g
–Saturated fat 1g
Dietary fibre 5g
© Healthy Life media Limited. All rights reserved. Reproduction without written permission prohibited.
This site complies with the HONcode standard for trustworthy health information

domain: food


It was 10 years ago now that a Skoda Octavia vRS romped into the Bonneville record books, setting a new 227.08mph maximum for the G/PS production class. It went as high as 228.642mph and claimed with it a little bit of history. Bonneville and the world had never seen anything quite like it - a front-wheel drive Skoda hatchback at almost four miles a minute. The Octavia was built to celebrate 10 years of the vRS in Britain; now, 120 months down the line, vRS is 20 years old - it was time to get the record breaker back in business.
The car you see here is that Bonneville car, albeit ever so slightly tweaked as part of its recommissioning - the Millbrook bowl presenting a slightly different challenge to the salt flats. So it's now running Michelin Pilot Sport 4S tyres instead of the Bonneville-specific rubber, roadgoing wheels so brakes can be fitted (seriously, it only had rear rotors alongside a parachute for the record), and the power has been turned down a tad for the longevity of the engine. So think nearer 600hp rather than the 700hp...
On hand to guide us through the drive was Ricky Elder, who helped build this incredible Skoda. Even 10 years later he's insatiably enthusiastic about the project and the challenges that were overcome. Getting 600hp from 2.0-litres is hard at the best of times; the vRS task was made more difficult by a change of engine. Back then, a facelift of the Octavia had just been launched, of which the donor car was one. But the revision saw the EA113 that the community (and Ricky) knew so well replaced with the EA888; now ubiquitous in VWs, Skodas, SEATs and Audis, but an unknown quantity back then. All the off-the-shelf parts lined up for the build wouldn't be suitable, and they had to start from the beginning. As in sending a pair of ECUs off to Revo because nobody knew how to work with them in 2011...
Still, Ricky and his team got there in the end, through some quite extraordinary measures. To comply with the production car class rules, the engine had to remain close to standard, so the block, pistons, valves and crank are as you'd find in a contemporary roadgoing vRS. The conrods were upgraded, and a ginormous Garrett GT3562R fitted, but the engine is closer to a regular one that you might think. For Bonneville, the gearbox from an Octavia Greenline was fitted (its eco-friendly long ratios meant a higher top speed), as well as a limited slip-diff to help find some purchase on the salt. Now it has the original 'box back in, though still with the spindly branch of a gearlever extending from the centre console.
Even in its more modest state of tune, this is a hugely intimidating Skoda Octavia. There's something you won't have read before. The car is red under the wrap, meaning climbing through the cage feels like clambering into a letterbox, and a metal bucket seat ensures it's little more accommodating. There's nothing inside that doesn't need to be, the inside of the Octavia as plush as a skip: pedals, wheel, digital dash, fuel pump switch, ignition switch and the one that makes the engine go kaboom. Everything else is bare red metal or a sheet aluminium 'dash'.
This might be the loudest car I've ever driven. Even through what looks a modest single pipe, it blares and drones and grumbles like nothing else. The 2.0-litre engine was certainly effective, though it's a long way from musical. Then begins the scariest bit: manoeuvring without stalling using a tough four-paddle clutch. Which goes ok, only to be followed by tailing a Millbrook hand towards the bowl; he knows his car, where he's going and what he's doing. The Skoda driver knows none of those things. In its defence, however, the Octavia bimbles well enough, even with a rock solid, unservoed brake pedal, more noise at 30mph than a Caterham at three times that and the worry that's always there driving unique, priceless cars. Even the five-door, hatchback ones.
The bowl would be the chance to really let rip, to feel what more than 300hp per litre feels like... up to 80mph. Sorry, there was a speed limit. Skoda wants to protect their asset and Millbrook have risk assessments to do. So there were no 200mph runs. But even up to 80mph (or so) the Bonneville car is extraordinary. And, to be frank, my eardrums wouldn't have taken much more.
There's turbo lag, and then there's 600-or-so-horsepower-from-2.0-litres turbo lag. Despite the racket the Octavia really isn't doing an awful lot for the first few thousand revs, pulling hard enough but not exactly with record breaking conviction. At about 5,000rpm it rockets into life, and once the shift lights start at 6,000rpm this definitely feels like a 220mph Skoda Octavia, thanks very much. For all of 1,000rpm or so, the powerband shockingly narrow. Changing up really dulls the violence, too, as it's back towards 4,000rpm or so and off boost. It's Russian roulette on four wheels, an explosive everything or pretty much nothing, except you know when the bang is coming. And it's hard to resist going back for more - and more and more. There's some fight in the steering to know just what the car is coping with, though the Skoda seems to deal with three times the power of standard impressively well. It's hard not to imagine what it might be like past 100mph, 150mph and even 200mph. Loud, undoubtedly, but also immensely exciting. Because speed always is, and especially when delivered in such an unlikely form.
Resisting the temptation to flout the speed limit - who's going to catch the 200mph Octavia? - the Skoda is soon back with its minders, including a relieved Ricky. A labour of love probably sells what was achieved here embarrassingly short. That the vRS is actually so user friendly really is a testament to their work, especially given it's been dormant for a decade. Though 200mph in a Skoda may have to wait for another day, the old Octavia has done more than enough to secure Hero status at little more than a third of its top speed. Which is what the most memorable cars always do. And nothing will live much longer in the memory than a 600hp, FWD Skoda - even once your ears have stopped ringing.
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Projector BENQ V7050i
- Projector Technology DLP
- Brightness 2,500 ANSI Lumens
- Contrast Ratio 2,000,000:1
- Resolution 4K UHD (3840×2160)
- Aspect Ratio 16:9
- Input HDMI
- Warranty ตัวเครื่อง 3 ปี หลอดภาพ 1 ปี หรือ 1,000 ชม.
A 4K Laser TV is a type of home entertainment system that combines a laser projector with a large, specially designed screen to create a high-quality viewing experience. These systems are typically designed for home theaters and provide ultra-high-definition (4K) resolution for a stunning picture quality. Here are some factors to consider when evaluating a 4K Laser TV system:
- Resolution: Ensure that the system offers 4K UHD resolution (3840 x 2160 pixels) for sharp and detailed images.
- Laser Light Source: Look for a laser light source as it provides longer life, consistent brightness, and color accuracy compared to traditional lamp-based projectors.
- Screen Size: Determine the screen size that fits your room and preferences. 4K Laser TVs are known for providing large, cinematic displays.
- Smart Features: Check if the system comes with built-in smart features such as streaming apps, Wi-Fi connectivity, and voice control for convenient access to content.
- Sound Quality: Consider the audio quality and whether the system includes a high-quality soundbar or audio system for immersive audio.
- Connectivity: Ensure the system has the necessary input ports for your devices, including HDMI, USB, and audio inputs.
- HDR Support: High Dynamic Range (HDR) support can enhance the contrast and color range of your content for a more vibrant viewing experience.


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Near-infrared-light regulated angiogenesis in a 4D hydrogel†
Light-responsive hydrogels are useful platforms to study cellular responses. Current photosensitive motifs need UV light to be activated, which is intrinsically cytotoxic and has a low penetration depth in tissues. Herein we describe a strategy for near-infrared (NIR) controlled activation of cellular processes (3D cell spreading and angiogenesis) by embedding upconverting nanoparticles (UCNPs) in a hydrogel modified with light-activatable cell adhesive motifs. The UCNPs can convert NIR light (974 nm) into local UV emission and activate photochemical reactions on-demand. Such optoregulation is spatially controllable, dose-dependent and can be performed at different timepoints of the cell culture without appreciable photodamage of the cells. HUVEC cells embedded in this hydrogel can form vascular networks at predefined geometries determined by the irradiation pattern. The penetration depth of NIR light enabled activation of the angiogenesis response through skin tissue with a thickness of 2.5 mm. Our strategy opens a new avenue for 4D cell cultures, with the potential to be extended to dynamically manipulate cell–matrix interactions and derived cellular processes in vivo.

domain: chemistry


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Ascenta Therapeutics Raises $50 Million in Series C Financing
Ascenta Therapeutics, Inc. recently announced that it has raised $50 million in a Series C round of financing, with $30 million funded in a first tranche and the remainder to be funded upon the satisfaction of specific milestones. The round was led by two investment funds managed by Perseus, L.L.C., a buyout and growth equity investor with over $1.6 billion under management. Norman Selby, Senior Managing Director at Perseus, has joined the Ascenta Board of Directors. Upon full funding, the Series C financing will bring the total amount raised by the company to $85.5 million.
All existing investors participated in this financing round, including Domain Associates, Sofinnova Ventures, Enterprise Partners Venture Capital, Scale Venture Partners (formerly BA Venture Partners), and US Venture Partners. Proceeds from the Series C financing will be used to advance AT-101, an oral pan-Bcl-2 inhibitor, through Phase 2 clinical trials in several cancers and to advance Ascenta’s pipeline programs to the clinic.
“This new financing will permit Ascenta to accelerate and broaden the development of AT-101 in multiple cancer indications and advance our MDM2 and XIAP preclinical programs,” said Ascenta’s CEO, Mel Sorensen, MD. “We are very pleased to have Perseus join our investor group during this important growth period for Ascenta.”
“Ascenta’s strong clinical focus and highly efficient research and development capabilities immediately attracted our attention,” said Perseus’ Selby. “We look forward to working with Ascenta’s Board and management team to create significant value for the company’s investors and employees - and ultimately for patients with cancer.”
“We welcome Perseus to our Board,” said Eckard Weber, MD, chairman of the Board of Directors of Ascenta. “This new round of funding will advance the company forward during a critical time when the clinical plan for AT-101 is expanding and additional compounds in Ascenta’s innovative pipeline are moving rapidly towards the clinic.”
Founded in 2003, Ascenta is a privately-held biopharmaceutical company that discovers and develops targeted new medicines for the treatment of cancer. The company has offices in San Diego, California and Malvern, Pennsylvania, and has a preclinical research facility in Shanghai, China. Its technology, licensed from both the National Institutes of Health and the laboratory of Dr. Shaomeng Wang at the University of Michigan, is focused on discovering molecules that hit vulnerable targets in endogenous apoptosis pathways and shut down cell growth and proliferation in cancer cells.
For more information, please visit www.ascenta.com

domain: economics


text:
Infantile hemangiomas are vascular tumors composed of proliferating endothelial cells. They uniquely undergo rapid expansion from birth to 6-8 months of age and subsequent slow dissolution over several years thereafter. Some hemangiomas are at risk of causing functional problems during their growth phase as seen in this upper eyebrow lesion obstructing the visual axis. Laser, surgical and medical treatment options are available for problematic hemangiomas. This patient was elected to undergo excision to completely remove the lesion and forego a long course of medical therapy (propranolol). Because of the their vascular nature, excision of hemangiomas requires careful planning and hemostasis. The hemangioma is marked in elliptical fashion along natural aesthetic facial lines along the brow. The inferior mark in incised first. Careful subdermal dissection is critical to completely excise to the hemangioma near the surface and find the appropriate plane. Control of bleeding is maintained by monopolar and bipolar electrocautery as well as dissecting the lesion from one side and alternating to the other. The plane of deep dissection is rarely below the subcutaneous layer thus protecting important nerves and vessels. Complete removal is possible. Closure is performed with dissolvable monocryl or PDS suture with dermabond superficially. A plastic eyeshield (blue) is placed at the beginning of case to protect the patient’s cornea during the procedure.
Bilateral ear keloid excision with steroid injection.
Contributors: Michael Golinko (MD) and Kumar Patel (PA)
A six-year-old male with history of skull trauma acquired in an ATV accident underwent emergency craniotomy three years ago. He now presents with bone resorption, frontal bossing, scalloped bone, and a widened scar in the middle of his forehead from the previous surgery.
Contributors:Michael Golinko, MD, MA, Eylem Ocal, MD and Kumar Patel, PA
Premature metopic suture fusion is corrected using fronto-orbital advancement and cranial vault remodeling to open the fused suture and allow for adequate brain growth.
Contributors: T. Shane Johnson
This video will outline the approach to a single port endoscopic carpal tunnel release, reviewing relevant anatomic landmarks, surgical views specific to the technique and unique operative tools.
Editor Recruited By: David Bozentka
Contributors:Katherine Faust and Jacob Brubacher
Internal distraction, or bridge plating, of distal radius fractures is a valuable tool for highly comminuted and unstable fracture patterns. Additionally, this technique is valuable for those fractures that extend into the metadiaphysis or for multiply injured patients requiring stable fixation for mobilization. Bridge plating allows for stable fixation in poor bone quality and early use of the injured extremity.
Contributors: Kumar Patel, PA-C and Gregory W. Albert
Posterior cranial vault remodeling post shunt induced Crainiocerebral Disporpotion (CCD) Patient is a 5 y/o boy having frequent headaches which may be indicative of increased intra-cranial pressure in addition to a step-off deformity of his posterior calvarium.
Contributors: Jonathan Isaacs and Amy Kite
Median nerve autogenous vein wrapping for revision carpal tunnel release due to traction neuritis.
Editor Recruited By: David Bozentka, MD
Contributors: Michael Golinko and Kumar Patel
Removal of an approximately 5 cm congenital alopecia using an O to Z or
yin-yang flap method.
Stage 1 Microtia Repair using rib cartilage and modifications to the Nagata method of auricular formation.

domain: medical


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Posted by Ed Garcia on March 01, 2002 at 12:41:44:
Yes, as well as the Hart program. Jennifer these are programs designed to help someone who may not qualify for a loan become a homeowner.
Although they may not directly benefit us as investors, do to they don’t do NOO (none owner occupied). Indirectly they can benefit us because they can help us sell our properties to someone who may not qualify for other types of financing.


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Opening up the 2020 summer season, the Madison Legion team jumped out to a 9-0 advantage after 2 1/2 innings, cruising to a 19-3 win at Dell Rapids on Wednesday night. Dells committed 7 errors. Madison scored three runs in the first, four in the second, two in the third and then three in the sixth, with seven in the seventh.
Zach Whitlock had 3 hits and 5 RBI’s to pace the Madison offense. Tyler Tappe pitched the first 4 1/3 for the visitors, who moved to 1-0 on the season. Madison League will be back in action this weekend, in a doubleheader Saturday at Humboldt/Hartford.

domain: news


text:
- Meeting report
- Open Access
Leukocyte adhesion and recruitment, and alpha-1-antitrypsin deficiency: a report from ATS 2001, May 18-23, San Francisco
Respiratory Research volume 2, Article number: E004 (2001)
The program at this year's American Thoracic Society international conference included over 300 scientific and clinical symposia. In this report I have reviewed the data presented on two important areas of lung inflammation, namely leukocyte recruitment and alpha-1-antitrypsin deficiency. Highlights included work from a number of groups identifying the contribution of specific leukocyte adhesion molecules (CD18, CD11a and vascular cell adhesion molecule-1) which varied according to the site and nature of the initial inflammatory stimulus. In addition work was presented examining the contribution of various chemoattractants to the process of leukocyte recruitment in chronic obstructive pulmonary disease, with leukotriene B4 in particular appearing to play a major role. In alpha-1-antitrypsin deficiency other molecules may also be important and work was presented demonstrating the pro-inflammatory potential of alpha-1-antitrypsin polymers in the lungs of these patients. These advances in the understanding of the basic mechanisms of inflammation will, in the future, allow the development of novel anti-inflammatory therapies for a variety of lung diseases.
The American Thoracic Society international conference is the largest gathering of lung specialists in the world, attended by over 15,000 people from 80 countries. The meeting aims to offer the latest and most significant developments in clinical practice, and clinical and basic research to physicians, scientists and health care workers. The program this year was made up of more than 300 scientific and clinical symposia. In this report I will concentrate on two important aspects relating to the basic mechanisms of inflammation in lung disease, namely leukocyte recruitment and alpha-1-antitrypsin (A1AT) deficiency.
Leukocyte adhesion and recruitment
Unique mechanisms of leukocyte migration from the bloodstream to the lung have been proposed with regard to the profile of the adhesion molecules, cytokines and chemokines involved, providing potential targets for pharmacological agents to control the inflammatory process. Data presented at this conference provided further insight into the mechanisms of leukocyte adhesion and recruitment into the lung and the potential effects of therapeutic agents on this process.
There is accumulating evidence that the mechanisms involved in leukocyte recruitment into the lung are dependent upon the stimulus and the site of migration. Data from SJ Hislip (University College, Ireland) demonstrated that the conversion from CD18-independent to CD18-dependent leukotriene B4 (LTB4)-induced and IL8-induced migration during acute inflammatory episodes may be due to n-formyl methionyl leucyl phenylalanine priming . This effect was demonstrated using healthy neutrophils and antibodies to the CD11/18 integrin complex. In addition U Maus (Justus-Liebig-University, Germany)  reported that monocyte recruitment to mouse alveoli was dependent upon CD18, VLA-4 and intercellular adhesion molecule-1 under basal conditions, but following bacterial endotoxin stimulation CD11a and vascular cell adhesion molecule-1 were also involved, indicating a switch of mechanism. As well as bacterial endotoxin, cigarette smoke can also up-regulate adhesion molecule expression in the lung tissue. AJ Heires (University NE Medical Centre, USA) reported that cigarette smoke extract was able to up-regulate the expression of intercellular adhesion molecule-1 on human airway epithelial cells . This effect could be abrogated by a C5a receptor antibody, implicating this molecule in the pathological process. AR Sousa (Guy's Hospital London, UK) presented data suggesting that the mechanisms controlling leukocyte influx also differed according to airway level and disease phenotype . This group found that the expression of granulocyte/macrophage colony stimulating factor in the large airways was significantly higher in smokers compared to non-smokers, and in chronic obstructive pulmonary disease (COPD) patients with airflow obstruction compared to subjects with normal lung function. No differences, however, were found in the small airways.
Studies using airway secretions are now also providing some insight to the contribution of the various cytokines and chemoattractants to leukocyte recruitment into the lungs of patients with chronic lung diseases such as COPD. IS Woolhouse (Queen Elizabeth Hospital Birmingham, UK) and KM Beeh (University Hospital Mainz, Germany) demonstrated (using different methodologies) that the contribution of LTB4 to the neutrophil chemotactic activity of sputum in COPD was significantly higher (30-50%) than that of IL-8 (16-30%) [5,6]. In addition DK Nelson (University of Arizona, USA) et al. were able to demonstrate that the increased chemotac-tic activity in exhaled breath condensate from smokers could be attenuated using an LTB4 antagonist . Taking these data together it would appear that LTB4 is a particularly important neutrophil chemoattractant in smoking-induced lung disease.
In addition to the neutrophil, monocyte recruitment to the lungs is also likely to be important in COPD. SL Traves (National Heart and Lung Institute, London, UK) reported that in patients with COPD the migration of monocytes to growth-related protein α was significantly increased compared to monocytes from healthy volunteers . This group also found that there were significantly higher levels of monocyte chemoattractant protein-1 and growth-related protein α in the sputum in COPD compared to healthy volunteers and smokers. Interestingly, KM Beeh (University Hospital Mainz, Germany) also found that monocyte migration in sputum from patients with lung cancer was increased, compared to smokers and healthy controls . This effect appeared to be mediated by the CC chemokine, macrophage inflammatory protein-1α as chemotactic activity could be suppressed with an anti-macrophage inflammatory protein-1α antibody.
Finally three studies were presented showing how a number of COPD therapies, both in current use and potential agents for the future, may exert beneficial effects through the suppression of leukocyte migration. J Bishara (Southampton General Hospital, UK) studied the in vitro effects of fluticasone and salmeterol  and M Mikami (Tokyo Metropolitan Hiro-o General Hospital, Japan) studied the mucoactive agent s-carboxymethyl cysteine . Both research groups were able to demonstrate significantly reduced transendothelial migration when neutrophils were incubated with these agents.
MP Pruniaux (Pfizer Laboratories, Fresnes, France) examined the effect of a novel phosphodiesterase 4 inhibitor on neutrophil numbers in bronchoalveolar lavage following lipopolysaccharide inhalation in rats . This group found pre-treatment with this drug successfully inhibited neutrophil recruitment to the lungs of these animals and concluded that this therapeutic strategy may prove efficacious in the treatment of lung inflammation.
The early concept of the development of emphysema in patients with A1AT deficiency was based on a simple balance theory where the amount of neutrophil elastase released in the lung exceeded the amount of A1AT present. The net result was persistence of elastase activity leading to accelerated lung destruction. However it is now becoming clear that the pathogenic process is more complex than first believed.
A number of studies presented at the conference highlighted the influence of free elastase on aspects of host defences as well as connective tissue breakdown. T Spencer (University of Florida College of Medicine, USA) reported that alveolar macrophage function in patients with A1AT deficiency, as measured by lipopolysaccharide-stimulated IL-1β production, was significantly reduced compared to controls . This appears to be an elastase-related effect given that IL-1β production was inhibited in control macrophages incubated with concentrations of elastase similar to that seen in A1AT deficiency. In addition, P Sivasothy (University of Cambridge, UK) found that when A1AT was cleaved by free elastase in cystic fibrosis, it was unable to bind to human neutrophil defensin-1, a potent pro-inflammatory mediator released with elastase from the neutrophil azurophil granule .
Free elastase may also influence leukocyte recruitment in A1AT deficiency. IS Woolhouse (Queen Elizabeth Hospital Birmingham, UK) reported that the chemotactic activity of sputum from patients with A1AT deficiency is increased compared to matched control patients with COPD . The major contribution to this chemotactic activity was from LTB4, which has previously been shown to be produced by alveolar macrophages in response to free elastase . Other molecules present in bronchial secretions may also be important in leukocyte recruitment. JS Parmar (Addenbrookes Hospital, Cambridge, UK) examined the pro-inflammatory properties of A1AT polymers, which can be detected in the lungs of some patients with A1AT deficiency . He found that the polymers were able to induce neutrophil chemotaxis as well as shape change which may further compound the lung damage seen in vivo. H Parfrey (Cambridge Institute for Medical Research, UK) attempted to prevent this polymerisation by introducing mutations into an interhelical cavity on the surface of A1AT, however these mutations were ineffective .
Although the tissue damage seen in A1AT deficiency is thought to be predominantly neutrophil-mediated it is now becoming clear that the other cells may be involved. N. Kokturk (University of Florida College of Medicine, USA) reported that, despite the presence of increased levels of neutrophilic burden in bronchoalveolar fluid from subjects with A1AT deficiency, bronchial biopsy neutrophil counts were not raised . This may be due to neutrophil migration into the airway lumen; however, M Hofer (University Hospital Zurich, Switzerland) found no difference in either intraluminal or intramural neutrophil counts in bronchiolar specimens from patients with A1AT deficiency and end-stage emphysema . This group did, however, find significantly higher numbers of lymphocytes in the A1AT-deficient subjects, which may suggest a role for this cell in the pathogenesis of the disease.
The pathological and biochemical processes have been further studied in animal models of A1AT deficiency. These models also provide an opportunity to study the effects of A1AT augmentation therapy on these processes. G Lungarella (Sienna University, Italy) reported the pathological changes seen in the pallid mouse (which has a partial genetic deficiency of A1AT) following chronic cigarette exposure compared to room air exposed controls . In the smoking mice he found that the emphysematous lesions were more severe and were associated with cellular infiltration and proliferation. In a similar study, Y Takubo (University of Utah, USA) compared the differences in smoke-induced emphysema between pallid and wild type mice . This group found that the two types of mice developed different types of emphysema, with the pallid mouse resembling human panlobular emphysema and the wild type resembling human centrilobular emphysema. A Guerassimov (McGill University, Montreal, Canada) attempted to attenuate the smoking-induced emphysema in pallid mice by gene transfer of human A1AT . There was no difference, however, in degree of emphysema following intramuscular injection of the human A1AT vector. Immunostaining of the vector-injected muscle suggested this lack of effect may be due to accumulation of the protein in the muscle.
The data presented at this conference highlight the considerable advances that have been made into the understanding of the basic mechanisms of inflammation in lung disease. We are now beginning to unravel the role of the individual adhesion molecules and cytokines in leukocyte recruitment into the lung with particular reference to the site and stimulus for migration, as well as disease phenotype. In alpha-1-antitrypsin deficiency the complex mechanisms of elastase-mediated lung destruction via effects on host defences are becoming clearer. In both of these areas this understanding should allow the development of specific novel anti-inflammatory therapies for acute and chronic lung diseases in the future.
chronic obstructive pulmonary disease
Hislip SJ, Mackarel AJ, FitzGerald MX, O'Connor CM: Pre-exposure to FMLP causes normal neutrophils to mimic neutrophils from patients with acute pulmonary infection in migrating to interleukin-8 (IL-8) or leukotriene (LTB4) using the CD18-dependent as opposed to CD18-independent migratory pathway. Am J Respir Crit Care Med. 2001, 163: A987-
Maus UA, Ermert L, Ermert M, Seeger W, Lohmeyer J: Molecular pathways of monocyte recruitment into lung alveoli of mice under non-perturbing and acute inflammatory conditions. Am J Respir Crit Care Med. 2001, 163: A986-
Heires AJ, Wyatt TA, Romberger DJ, Thompson EG, Sanderson SD, Floreani AA: The effects of cigarette smoke extract (CSE) and C5a on ICAM-1 expression in human airway epithelial cells in vitro. Am J Respir Crit Care Med. 2001, 163: A986-
Sousa AR, Lams BE, Lee TH: Cytokine expression in large and small airway submucosa in COPD. Am J Respir Crit Care Med. 2001, 163: A78-
Woolhouse IS, Bayley DL, Stockley RA: The chemotactic activity of sputum in chronic obstructive pulmonary disease (COPD) with and without alpha-1-antitrypsin deficiency (AATD). Am J Respir Crit Care Med. 2001, 163: A988-
Beeh KM, Kornmann O, Culpitt SV, Giembycz MA, Buhl R, Barnes PJ: Chemotactic activity of sputum from steroid-naïve COPD patients: role of interleukin-8 and leukotriene B4. Am J Respir Crit Care Med. 2001, 163: A347-
Nelson DK, Garey KW, Campbell S, Hadeli K, Habib M, Hoyt JC, Sato E, Koyama S, Rubinstein I, Robbins RA: Exhaled breath condensate contains increased neutrophil chemotactic activity in smokers. Am J Respir Crit Care Med. 2001, 163: A987-
Traves SL, Culpitt SV, de Matos C, Russel REK, Barnes PJ: Peripheral blood mononuclear cell chemotaxis to MCP-1, GROalpha and IL-8 in COPD. Am J Respir Crit Care Med. 2001, 163: A987-
Beeh KM, Kornmann O, Ernst M, Beier J, Micke P, Buhl R: Chemotactic activity of sputum from patients with unresectable lung cancer: role of M1P1-alpha. Am J Respir Crit Care Med. 2001, 163: A477-
Bishara J, Jones T, Marshall LJ, Howarth PH, Shute JK: Salmeterol and fluticasone propionate inhibit neutrophil transendo-thelial migration. Am J Respir Crit Care Med. 2001, 163: A597-
Mikami M, Hashimoto Y, Nakamura S, Kudoh S: Anti-inflammatory effect of mucoactive agents, S-carboxymethyl cysteine, Ambroxol and Bromhexine, through inhibition of lung injury by neutrophils. Am J Respir Crit Care Med. 2001, 163: A991-
Pruniaux MP, Mottin G, Planquois JM, Bertrand C: The selective phosphodiesterase 4 inhibitor CI-1044 (PD-189659) inhibits LPS-induced neutrophil recruitment and TNF-alpha release in rat airways. Am J Respir Crit Care Med. 2001, 163: A991-
Spencer T, Brantley M: Alveolar macrophage dysfunction in patients with α1-antitrypsin deficiency. In Proceedings from the 4th Annual Alpha-1 Research Forum. Edited by Sandhaus RA. San Francisco: Alpha-1 Research Foundation,. 2001, 13-
Sivasothy PR, Dafforn TR, Hiemstra PS, Lomas DA: Immunoglobulin G protects against human neutrophil defensin-1 mediated epithelial damage in patients with cystic fibrosis. Am J Respir Crit Care Med. 2001, 163: A489-
Hubbard RC, Fells G, Gadek J, Pacholok S, Humes J, Crystal RG: Neutrophil accumulation in the lung in α1-antitrypsin deficiency: spontaneous release of leukotriene B4 by alveolar macrophages. J Clin Invest. 1991, 88: 891-897.
Parmar JS, Chilvers ER, Bilton D, Lomas DA: The modulation of neutrophil function by conformations of alpha-antitrypsin. Am J Respir Crit Care Med. 2001, 163: A992-
Parfrey H, Lomas DA: Exploration of a surface cavity of alpha antitrypsin: implications for rational drug design to prevent polymerisation and disease. Am J Respir Crit Care Med. 2001, 163: A231-
Kokturk N, Szwed T, Rouhami F, Brantley M: The relationship of upper airway and lower respiratory tract neutrophils in alpha-1 antitrypsin deficiency. Am J Respir Crit Care Med. 2001, 163: A210-
Hofer M, Gaspert A, Vogt P, Georgescu CL, Weder W, Russi EW, Boehler A: Small airway disease in endstage emphysema due to alpha-1 antitrypsin deficiency. Am J Respir Crit Care Med. 2001, 163: A75-
Lungarella G, Cavarra E, Bartalesi B, Fineschi S, Lucattelli M, Lunghi B, Martorana PA: Cigarette smoke accelerates the development of emphysema in pallid mice with genetic deficiency of alpha 1-PI. Am J Respir Crit Care Med. 2001, 163: A232-
Takubo Y, Guerassimov A, Triantafillopoulos A, Ghezzo H, Hoidal JR, Cosio MG: Morphological differences in cigarette smoke-induced emphysema in C57BL/6 and pallid mice. Am J Respir Crit Care Med. 2001, 163: A345-
Guerassimov A, Song S, Takubo Y, Triantafillopoulos A, Ghezzo H, Flotte TR, Cosio MG: Gene transfer of alpha 1-antitrypsin in smoking pallid mice. Am J Respir Crit Care Med. 2001, 163: A79-
About this article
Cite this article
Woolhouse, I. Leukocyte adhesion and recruitment, and alpha-1-antitrypsin deficiency: a report from ATS 2001, May 18-23, San Francisco. Respir Res 2, E004 (2001). https://doi.org/10.1186/rr78
- chronic obstructive pulmonary disease
- leukocyte adhesion molecule

domain: biology


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Arnold guides readers toward leading Christ-like lives amid the stress and strain of modern life.
Perhaps the hardest thing about following Christ is translating our good intentions into deeds. Christ calls us, and we yearn to answer him, but time and again we lose resolve. Is discipleship really possible today? Many of the selections in this book offer answers to specific needs or problems. Others grapple with broader themes such as world suffering, salvation, and the coming of the kingdom of God. All of them pulsate with conviction and compassion, giving fresh hope to those who find themselves lonely or disheartened in the daily search to follow Christ.

domain: library


A shipment of supplies from Lexington will be shipped to Jackson County Friday to help dozens of dogs found living in filth.
Earlier this week, officials found more than 100 dogs living at a home in the Sand Springs Community.
Some dogs were dead. Others were in bad shape.
The Lexington Humane Society has been collecting food, bedding and other supplies for the animals.
Most of the dogs remain at the Gray Hawk Animal Clinic in Jackson County.
You can contact the clinic to offer assistance by calling (606) 287-8475.


Meaford council held a mandatory public meeting on January 15 to allow public input on the 2018 municipal budget before final approval, which is expected to take place at council's January 29 meeting.
Meaford's Treasurer Darcy Chapman told council that the municipal levy will increase by three percent, but thanks to a reduction in the education rate along with a small 0.36 percentage increase in the county rate, the blended rate increase for Meaford property owners in 2018 will be approximately 1.25 percent. The increase will add roughly $45 to the property tax bill of an average home in the municipality.
In September council directed staff to prepare a draft budget that included a maximum overall tax levy increase of four percent, including allocations of one percent dedicated to roads capital funding, one percent for capital funding of bridges, and 0.5 percent for capital funding of municipal facilities. Additionally council directed staff to “budget any tax levy increases resulting from real assessment growth due to new development and building construction assessment into the General Infrastructure Reserve Fund for future capital projects.”
Staff had prepared a budget for next year complying with council's wishes, and a rate increase of 3.893 was proposed, however some good fortune allowed staff to arrive at the December 11 meeting with a similar budget package though with a required rate increase of only 1.603 percent.
Meaford Treasurer Darcy Chapman told council in December that the municipality will receive $171,200 in additional OMPF funding for 2018, and that unexpected news combined with some smaller savings found within the budget allowed staff to bring the rate increase down to 1.603 percent.
Council welcomed the good news, and asked the treasurer to prepare a final budget document reflecting a 3.0 percent rate increase, with the additional $185,000 that would be realized by bumping the increase from 1.603 percent to 3.0 percent to be dedicated to infrastructure needs.
While roughly 20 residents attended the public meeting, virtually all who attended were members of the Meaford Rotary Club, who protested a 125 percent increase in the fees they pay for renting the Terrace Room at Meaford Hall for their weekly meetings.
“There is an issue in the budget that is of some importance to the Rotary Club,” Meaford Rotary Club President Bill Beatty told council. “As you may be aware we meet weekly at Meaford Hall, and have done for a number of years. We are now being faced with a facility rental increase of 125 percent year over year, which to be honest is unreasonable.”
Beatty said that Rotarians understand the need for rate increases but he argued that the increase was excessive.
“We had anticipated having to pay a higher rent, and we were willing to pay a higher rent, and we're still willing to pay a higher rent, but this is beyond the pale,” Beatty said.
Beatty said that the increased rates would cause financial hardship for the club which already has difficulty attracting new members.
“We try hard to increase membership and attract new members, and those ongoing efforts have told us that cost of membership is critical,” Beatty told council. “We are, as you know, an old club, and we're getting older. We're trying hard to get younger, and to get more energetic, and we think that for the Rotary to continue contributing to the Meaford community in the manner in which it has done over the last number of years, we must get younger, we must get more energetic, so attracting new members is critically important to us, and this type of rental increase will make it all that much more difficult.”
During discussion with council it was noted that under the new fee structure the Rotary Club will be asked to pay a $30 fee for use of a microphone during their meetings, a fee they haven't had to pay in the past. Some Rotarians found the request for the fee ironic given that they say the Rotary Club donated the first microphone to Meaford Hall.
Members of council expressed a desire to find a solution for the club, though not by reducing the increase to the rates which staff say are necessary in order to assure cost recovery, but rather through the community grant program should the club not be able to negotiate a suitable rate with Meaford Hall management.
No other members of the public expressed concerns about the 2018 budget during the mandatory public meeting. Council will give final approval to the budget at their Janaury 29 meeting.
All budget documents and presentations are available on the municipal website (meaford.ca/budgets).


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It’s a bird, it’s a plane…it’s Michael B. Jordan! According to a new report, the actor is planning to develop his own Superman project with HBO Max.
Collider reported the news earlier on Friday that Jordan’s project will be separate from the upcoming Superman movie starring a Black Clark Kent, which is being executive produced by J.J. Abrams. While Jordan was rumored to be putting on Superman’s cape for that movie — the script for which is being penned by Ta-Nehesi Coates — the Creed actor brushed off the speculation at the time, saying, “I’m flattered that people have me in that conversation. It’s definitely a compliment, but I’m just watching on this one.”
Instead, his new rendition with the streamer will reportedly focus on the Val-Zod version of the character in a limited series format, with potential that Jordan will possibly step into the iconic superhero’s costume on top of his role as an executive producer.
For the uninitiated, Val-Zod is Kryptonian from Earth 2 who becomes the second Superman a character entirely different from the typically white Clark Kent. Another Black iteration of the hero is Calvin Ellis, both Superman and President of the United States on Earth 23.
Most recently, Jordan starred in Amazon Prime’s Without Remorse, based on the 1993 Tom Clancy novel, and is also developing a live-action Static Shock movie. Up next, he will make his directorial debut in Creed III, which is expected to hit theaters over next year’s Thanksgiving holiday. Meanwhile, back in April the Black Panther star opened up to The Hollywood Reporter about the legacy left by his late co-star Chadwick Boseman.


Learn piano online by reading our articles here on the website. The articles bring you information about learning to play this wonderful musical instrument, offering a rich source of knowledge for the passionate learner.
Offering tips and advice on how to improve your piano technique and the piano exercises that can accelerate your progress. all-piano-online.com introduces suitable classical and modern piano songs for you to play and exercises to practice with.
A treasure trove of resources about learning to play the piano that is sure to supplement your continuous improvement.
The artistic image of a song
...To understand the said story the theory around which it revolves; as in the music theory has to be understood. Much like trying to uncover the mysteries of the universe the laws of physics has to be understood.
Here is an example taken from Turkish March, shown in Image 1.
The song is written in the key of A major, having that information we can expect to find combination of chords consisting of notes that make up the key of A major. The hassle of decoding each and every note on the music score and then locating them on the piano is simplified when the pianist knows this. For example, in Image 1 the tonic triad chord of A Major appears on numerous occasions as marked in red circles...learn more about playing the piano online, read the full article>>>
...here is how I play staccato. Instead of using the arms to hit the keys, I use my wrists and they have to be flexible. My fingers are always already in position in contact with the keys before I attempt the staccato. Like a fulcrum, I let my wrists flex the fingers to press and spring off the keys. Picture a diver jumping off a springboard, it is a similar concept.
One mistake a beginner often makes, which I was also guilty of is to use the arms to play staccato. The arms are big and heavy, therefore do not have the speed to produce a crisp staccato. Ignoring this fact only creates tension in the muscles and it is painful. The wrist however is a lean, mean staccato machine. When unlocked and separate from the arm its nimbleness produces a firm and lively staccato...learn more about playing the piano online, read the full article>>>
A musical phrase is built from several smaller, shorter conceptions of music. A line of musical phrase would probably be built from 2 or 3 conceptions. For example, let us take a look at this line from Rondo Alla Turca as shown in Image 1 below.
In my opinion it is made up of 3 musical concepts, not because there are three bars in it, but the pattern in the combination of the notes and their arrangements within each bar is distinct. The distinction is what I meant as musical conception...learn more about playing the piano online, read the full article>>>
One of the most famous piano songs ever composed, Turkish March’s rare legato phrases in a hectic environment occupied by staccatos offer the chance to create a contrasting sound that sparkles over the rest by joining the notes in a binding legato.
...the rare existence of legato phrases in Rondo Alla Turca is like an oasis in a hectic environment occupied by staccatos. Take advantage of the chance to create a contrasting sound that sparkles over the rest by joining the notes in a binding legato. It is done through the use of the hands by lifting the fingers at the last moment rhythmically before playing the next notes.
Overcome sympathetic finger movement by building strength in the fingers through the practice of bouncing the 1st and 3rd fingers off the keys of the piano and then bringing them down. Repeat the movement with the 2nd and 4th fingers. It can be done with any 2 notes that are separated by at least 2 intervals...learn more about learning the piano online, read the full article>>>
As the title suggests Turkish March is well…a march not a stroll. Therefore a faster pace in playing it is unavoidable. Gain speed through rhythmic practice in small cells, expanded incrementally evolving into groups of 2 bars. Forget not to forge the artistic image of the song by including dynamics in the execution
...Untrained and ill prepared, playing fast (as in short, short, short…or quick, quick, quick…) is like opening a can of worms. All the unpleasantness such as stumbling, hesitations and playing the wrongs keys are exposed. Not to mention the forced errors on the finer nuances of a composition such as tone, rhythm and expression.
Hence the necessity to practice slow at first in small sections, execute every requirement accurately before speeding up. Even then, speed up incrementally in small cells as explained earlier...learn more about playing the piano online, read the full article>>>
Acquire the strength needed in the fourth and fifth fingers to play piano songs with panache. The exercises explained build strength as well as flexibility and agility
...A lot like going to the gym to work out by lifting weights to build upper body strength, we do it by increasing the load we lift, for example from 10kg to 20kg to 30kg – compared to the earlier exercise explained in the above paragraphs, this next exercise is a heavier load practiced to build stronger 4th and 5th fingers.
With the fingers of the right hand place the thumb on C, index finger on D and the pinkie on G. Press and hold them down at the same time without ever lifting it while playing the rest of the keys one at a time. As in ; E (with the middle finger), F (with the 4th finger)...learn more about playing the piano online, read the full article>>>
The wrists lateral movements and adjustments are the factors that determine the smooth connection of notes that bind a musical phrase, guiding the hands that control the fingers in music making.
...The wrists' job is to move between the positions on the keys of the piano. I do not mean keys located in the higher or lower octaves. What I mean is the location on a key, such as the upper location between black keys, middle and the near edge before falling off the keyboard.
The wrists guide the hands to land the fingers firmly at these locations and more significantly they get the arms to be involved with the work. Bouncing off one chord, transitioning to next one and another are big movements that the arms carry out, piloted by the up down and side to side movements of the wrists. The combination opens a 3-dimensional, 180 degrees space for fingers to travel through, without which they would only be limited to a piston-like movement that causes strain...learn more about playing the piano online, read the full article>>>
Articulation of phrases in piano songs, through the combination of good pedaling and softly played notes as in pianissimo could be made to sound magnificent. Learn how it is done in this article.
...One way to project the artistic image of piano songs is the proper use of the sustaining pedal. Its mechanism affects the vibration of the strings in the piano. Putting it under the control of your feet gives you dominance over the strings’ vibration, therefore holding the control over the sonorous quality of the sound being produced. It provides you with one apparatus to project the artistic image of the song. Great articulation can be achieved by blending the well-timed use of the sustaining pedal with softly played notes (pianissimo)...learn more about playing the piano online, read the full article>>>
An elegant fortissimo phrase in piano songs can be accomplished by layering the sounds. It is done by identifying the strong base notes and them playing loud.
...By keeping the fingers in contact with the keys, I am able to keep a rounded sound without losing its tonal quality while also having control over the notes I am striking, be it chords or octaves.
The next thing to remember when playing fortissimo is, when pressing the keys go all the way to the bottom of the keys. Once I reach it, without lifting the fingers away from the keys I would release the effort. This way energy is conserved, it is like taking an ‘unauthorized rest’. It sustains me to continue playing with undiminishing strength throughout the rest of the song.
How the keys are pressed matters too. I use my energy from the upper body and push them backwards as if I was pushing the piano through the wall. I do not need to do this with every note. Recognize the strong base note. Usually it is the top note of a phrase, play them fortissimo and less so in the middle notes...learn more about playing the piano online, read the full article>>>
When playing piano songs develop a sharper sense for the music by focusing on the feel and sound to develop a better sense for when to press on sustaining pedal
To create a masterpiece an artist utilizes a set of tools available to him. Michaelangelo utilized the hammer to chisel the statue of David then utilized the brush to paint the ceiling of the Sistine chapel. The piano is of course one instrument/tool a musician utilizes to create sounds pleasant to hear. On a more miniscule scale, tools are available that make the music created on the piano that much more beautiful...learn more about playing the piano online, read the full article>>>
What does it take be become a pianist capable of balancing melody and accompaniment well? Witnessing Sylvia's play provided some hints, learn more about playing the piano online, read 'Balancing melody and accompaniment'
The importance of chromatic scales needed to play Bach’s ‘Well Tempered Clavier’ explained, and what it takes to execute them. Learn more about playing the piano online read 'Chromatic scales'. Inspired by the performance of the Actors Studio Chorus and Orchestra
Combinations and arrangements of a set of musical notes result in a multitude patterns of rhythm, grasp rhythm in a piano song through understanding of music theory, learn piano online read 'Grasping rhythm'
Finger agility and delicate touch combined with technical mastery developed over years of practice are required to make music as beautiful as these, read 'Learn piano online - Classical romantic'
The little pinkie is the weakest finger when playing the piano. You can make it stronger by practising these 2 exercises.
Learning how to play the piano is without doubt a daunting task. Stay positive and overcome frustrations, learn how to improve your piano online with these methods.
One of the most gratifying emotions one can feel is when a piano song is played to perfection. Learn more about playing the piano online, find out how to get rid of playing mistakes with these technique building ideas.
Because of the sophisticated complexities in its design, I have always thought the piano is the most versatile musical instrument. It came as a shock to see how much more awesome it was the first time I watched a string quartet accompanying it. Imagine my astonishment when that experience was surpassed the moment I heard the harp accompanying the piano.
One typically conjures up an image of a Greek goddess plucking away under a waterfall in a faraway mythical land when harp is mentioned. I was amazed and pleasantly surprised to discover it is actually a still popular musical instrument.
Learning how to play the piano was what led me to discover its existence. I was in my second year of lessons and was struggling to play ‘Well Tempered Clavier’ by Bach, so I decided to look for a recording of the song so that I can listen and absorb the rhythm in the hopes of being able to play it well enough sooner. I found what I was looking for with an unexpected bonus – a recording of Well Tempered Clavier’ performed on the harp accompanied by the piano....learn more about playing the piano online, read the full article>>>
Classical music often offers the option to play in rubato. It is indicated as a playing instruction in the music score. When such opportunity presents itself, it would be a grave sin for a pianist not to take advantage by letting loose her musical creativity in articulating the melodies.
Jazz piano on the other hand is music in rubato overdrive. Tempo and articulation can be expressed with absolute freedom whenever. The only limitation is your own wealth of repertoire and energy level.
What is rubato?
The temporary disregarding of strict tempo to allow an expressive quickening or slackening, usually without altering the overall pace. [reference: Oxford Dictionary of English @ Oxford University Press 2010, 2017]
Or an alternative definition: A flexible tempo; not strictly on the beat.[reference: WordNet 3.0 Copyright 2006 by Princeton University]
Leading the Big Band of Penang on the eve of Labor Day weekend with passion, his control over the 20 musicians playing different instruments was so complete that they were able to maintain a consistent pulse throughout the performance.
Like a mad scientist engulfed in his experiments, oblivious to the world around him. Perhaps, too harsh of a way to describe him, I meant it as a compliment though, alright I’ll re-phrase it; Jerome is one passionate dude.
It is only natural that pulse is somehow a key component in music making. It is so for the simple reason that in the very universe we are occupying, some type of pulse is reverberating around us at all times. In the form of magnetic waves, light and sounds. My own beating heart generates a regular pulse, the neurons in my brain sparks billions of bursts of pulse in a second...learn more about playing the piano online, read the full article >>>
Most piano players are well acquainted with songs composed by Beethoven, Mozart, Bach, Liszt and many other great composers from the classical era.
Modern music be it jazz, hip hop or R & B are influenced by what they created hundreds of years prior. What we listen to now are evolved version of classical music.
Present day pop culture is dominated by western music just like in the world of classical music – there has been no Asian equivalent of a Mozart or Beethoven.
Every piano song I have learned so far were written by composers from Europe and America until one day when I was asked to play ‘The Moon Represents My Heart’... learn how to play the piano online, read the full article>>>
...take ‘Fantasie in C Major’ for example, the second movement in Op.17 featured a series of leaps not only intended to highlight Elaine’s pianistic skills but more importantly the resulting music injected a dose of freshness into my soul lifting my spirits up and I dare say in others listening in the audience as well. The similar effect piano music had on me years ago was what drove me to take up lessons in the first place. Who could resist playing music so gorgeous and feeling the keys under my fingertips, what a sensation!....learn more about playing the piano online read the full article>>>
Tips on playing piano songs, in this article suggestions on how to play Fur Elise is discussed and why the importance of acquiring agility and flexibility in the fingers is emphasized
...Notice the Italian term ‘poco moto’. It is a tempo direction literally translated as ‘with motion’. Music historians and scholars are of the divided opinion that since the song was not published during Beethoven’s lifetime it was not him who wrote the instruction, therefore it can be neglected.
However the instruction is meant for pianists to play the bar ‘not too fast but a bit slower’. When put together with the rest of the phrase, the subtle contrast in tempo infuse an extra layer of tone making it all the more attractive to listen to. Such seduction through piano music is made possible by she who plays with agile and flexible fingers...learn more about playing the piano online, read the full article>>>
With an untrained beginner performing piano songs, the non-deliberate action by the 4th finger known as sympathetic finger movement ruins the rendition. Explained in this article are ideas to overcome it. Learn more about playing the piano online, read the full article>>>


2018 Honda CR-V vs 2018 Mazda CX-5
When trying to find a crossover SUV that sips the gas and gives you plenty of power under the hood, look no further than the 2018 Honda CR-V and the 2018 Mazda CX-5. These two crossovers offer efficient standard 4-Cylinder engines that also deliver ample horsepower and torque. Not only do the 2018 CR-V and the 2018 CX-5 provide exciting drivetrain specs they also offer sleek and sporty exterior appeal. It is easy to understand how deciding between these two SUVs can be difficult and that is why we bring you this breakdown of their similarities and differences right here.
2018 Honda CR-V
2018 Mazda CX-5
|2.4L In-Line 4-Cylinder||Standard Engine||2.5L 4-Cylinder|
|184 HP/ 180 LB-FT||Horsepower/ Torque||187 HP/ 186 LB-FT|
|Continuously Variable w/ Sport Mode||Standard Transmission||6-Speed Automatic|
|26 MPG City/ 32 MPG HWY||Fuel Economy*||25 MPG City/ 31 MPG HWY|
Differences & Similarities
The graph above depicts the standard drivetrain specs of the 2018 Honda CR-V and the 2018 Mazda CX-5, and as you can see the 2018 CR-V delivers better fuel efficiency while the 2018 CX-5 provides slightly better horsepower and torque. The 2018 Mazda CX-5 only offers its standard drivetrain but the 2018 Honda CR-V makes a 1.5L Single-Scroll Turbocharged In-Line 4-Cylinder engine available. This 1.5L Turbo engine cranks out 190 horsepower and 179 lb-ft of torque while still averaging EPA fuel efficiency estimates of 28 MPG* in the city and 34 MPG* on the highway. Both the 2018 CR-V and the 2018 CX-5 offer All-Wheel Drive (AWD) across all trim levels and when ech model works with AWD the 2018 Honda CR-V increases its fuel economy advantage over the 2018 Mazda CX-5 even further.
The Honda CR-V and the Mazda CX-5 have seating for five people, but the 2018 CR-V provides passengers with more first and second-row headroom, legroom, and shoulder room than the 2018 CX-5 does. The 2018 Honda CR-V also provides 39.2 cubic feet of standard cargo room and 75.8 cubic feet with the rear seat folded flat, the 2018 Mazda CX-5 only offers 30.9 & 59.6 cubic feet respectively. With more efficient drivetrain options and more interior passenger and cargo space, the 2018 Honda CR-V is the easy choice over the 2018 Mazda CX-5. Take the 2018 Honda CR-V for a test drive today at Davenport Honda in Rocky Mount, NC today.


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I originally grow up in Germany and Art and photography have been a passion of mine sine I was a child. During my childhood in Germany, I had the chance to travel throughout Europe and Northern Africa with my parents. This early exposure to many culturally diverse environments, not to mention the people who lived in them, fascinated me. It is amazing what the human eye sees and can capture with a lens. The exquisite nature of light, dark and color can captivate the mind, body and sole ... most inspiring … My work has been highlighted in American Photography, Profoto, Select Magazine, Picture Perfect, Bahrain Confidential, Alcove Books, MAC-on-Campus, Photo Vogue Italy, Best of Photography (Photographers Forum), Creative Quarterly … I received my Masters in Fine Art form the Academy of Art University in San Francisco and have been teaching at the Art Institute of Charlotte. Today, based in Colorado, I am dividing my time between commercial and fine art photography, teaching, and alternative processing with her recently restored Deardorff Camera.
christine szeredy's Overall Rating
"Composition: good Styling: ok (move cords and wires) Exposure/Bracketing: ok (dont move tripod/please use a tripod) Color Balance: ok Image Quality: good Shot list: good Recommend: yes however, don't edit the images at all before sending to us - some had been clearly edited and cropped."
SmartShoot Partner 2014-06-05
"Great to work with, thanks."
SmartShoot Partner 2014-09-25

domain: artistic


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Chimney Rock Park sponsoring bird walk
Published: Friday, March 17, 2006 at 4:30 a.m.
Last Modified: Friday, March 17, 2006 at 12:00 a.m.
CHIMNEY ROCK -- Chimney Rock Park will sponsor "Raptor Rap," a guided bird walk with ornithologist Reece Mitchell on Saturday to mark the return of the rare Peregrine Falcon to the park.
The hike is set for 10:30 a.m. to 1:30 p.m. The $16.50 cost includes admission to the park for the day. The hike is $3 for annual pass holders and $8 for young people ages 6 to 15. Optional hikers' lunches are available.
The Peregrine Falcon has returned to the Hickory Nut Gorge area. The raptors tried unsuccessfully to nest in the cliffs of Chimney Rock Park in 2005. They are now trying to nest again.
Mitchell, a raptor expert from Flat Rock, will discuss the falcon and other birds of prey. He has worked in the Peregrine Falcon Recovery Project for more than 14 years. The hike meets in the Nature Center for a brief primer on the falcons and other birds of prey. Visit chimneyrockpark.com or call (800) 277-9611 to register.
Reader comments posted to this article may be published in our print edition. All rights reserved. This copyrighted material may not be re-published without permission. Links are encouraged.
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domain: hobby


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EXCLUSIVE: The Wu-Tang Clan’s Ghostface Killah and RZA and Shaun Redick of Impossible Dream Entertainment will produce Angel of Dust, a suspense horror thriller that Wu-Tang leader RZA will direct. Pic is inspired by true stories that happened around the hood to members of the global iconic rap group when they were growing up in and around the Staten Island Projects. A series of bizarre and horrifying events shaped their mind-sets to launched the Wu-Tang Clan to become a worldwide music powerhouse. The story was created by Wu-Tang member Ghostface Killah (aka Dennis Coles) and longtime manager Caruso. Script is by Matt Leslie and Stephen J. Smith (The Harrowing, Summer of ’84).
The Wu-Tang Clan will provide an epic new soundtrack produced by Ghostface Killah and Caruso for Angel of Dust, and RZA will also score the movie. All this happens as the group assembles today for the Sundance Film Festival premiere of the Showtime documentary series Wu-Tang Clan: Of Mics and Men.
Angel of Dust will be produced by Redick (BlacKkKlansman, Get Out) and Yvette Yates of Impossible Dream along with Wu-Tang’s Ghostface Killah & RZA, Gary Ousdahl of Foundation, and Caruso.
iWood Studios, which co-financed David Ayer’s new action thriller The Tax Collector, is headed by producer-financier Matt Antoun and will finance Angel of Dust. Pic is exec produced by Mark Strome, Mickey Gooch Sr, Jamie Adler and Jonnie Forster of Foundation.
The logline: Casey is a normal yet exceptionally smart teenager and talented rapper but after the mysterious death of his parents he’s been forced to grow up in NY’s roughest inner-city streets (known as Shaolin in Wu-Tang folklore), basically on his own. As life in the hood around him gets tragically worse he must put his skills to the test to survive not only the gangs, corrupt cops, junkies and bullies, but a serial killer with seemingly supernatural powers dubbed Angel of Dust by the media.
Said RZA: “The creative collaboration of RZA and Ghostface has stood the test of time through our music. Now the opportunity to put our creative energies together onto the silver screen has arisen and I’m turbo charged. Bong Bong!”
Said Ghostface, “It’s a blessing to partner with Oscar nominated producer Shaun Redick and Impossible Dream Entertainment, and to be doing business with my brother, RZA directing is a dream come true. Putting all these great minds to work together will be legendary.”
Said Redick: “It’s hard to fathom a better way to celebrate the Wu-Tang Clan’s 25th anniversary as rock and rap creative icons than producing a cutting-edge suspense thriller loosely based on true events that though terrifying helped shape one of the greatest groups of all time. The writers, Leslie and Smith have taken this original idea to seismic levels.”
RZA is repped by WME and Joe M. Carlone of King, Holmes, Paterno & Soriano; Leslie and Smith are APA and Jeff Portnoy at Bellevue, and their deal was negotiated by Marios Rush of Marks Law Group. Ousdahl is attorney Eric Feig; Caruso and Ghostface Killah are repped by Matthew Jacobs of Gray Krauss Sandler; Bob Abramoff of Burgee Abramoff and Redick negotiated the deals for all including RZA & Ghostface, the Wu-Tang Clan, writers Leslie and Smith and financiers.
© 2022 PMC. All rights reserved.

domain: entertainment


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In Heaven on Earth, respected art historian T.J. Clark investigates the very different ways painting has given form to the dream of God’s kingdom come.
He goes back to the late Middle Ages and Renaissance–to Giotto in Padua. Brugel facing the horrors of religious war, Poussin painting the Sacraments, Veronese unfolding the human comedy. Was it to painting’s advantage that in an age of enforced orthodoxy (threats of hellfire, burnings at the stake) artists could reflect on the powers and limitations of religion without putting their thoughts into words?
At the heart of the book stands Brugel’s ironic but tender picture of The Land of Cockaigne, but also Veronese’s inscrutable Allegory of Love. The story ends with Picasso’s Fall of Icarus, made for UNESCO in 1958, which already seems to signal–perhaps to prescribe–an age when all futures are dead.


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13-21 year olds meet regularly to share, support and inspire each other.
We support young musicians and songwriters to develop their own sound and to challenge themselves creatively.
We do loads of gigs and at least three community events throughout the year, supporting signed and unsigned artists.
Jamming Station Sessions
We are based in the Civic Hall, Totnes, where we have ample space to rehearse, break away into smaller groups, run workshops and make a big sound. We have a full PA and various instruments, a sound engineer, music leaders and young music mentors who all work together to provide a great resource for young musicians.
Sessions run throughout the school year and are booked in half-term blocks. We require half-termly commitment. Each term ends with a special public gig at our popular local music venue, the Barrel House, which is a stones throw from the Civic Hall.Click to Book Your Sessions


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Chinese Proverb Quotes
2+ Best Chinese Proverb Authors Quotes
The wisdom that this Chinese Proverb provides is almost simplistic in its obviousness. Thinking too much of the future or who we should be leads to tension and stress but in order for us to be relaxed, we must accept who we are. In a world of so many options, choices and expectations, stress can be a major cause of the anxiety and depression that often plagues people.
For most of us, however, getting angry isn't a problem, it's what we do after we become angry that often has negative ramifications in our lives. A hasty decision in a moment of anger can worsen a situation. This is why if you are patient and don't make hasty decisions you will 'escape hundred days of sorrow' that means you won't regret anything.

domain: literature


Jason Beddow was a research assistant professor in the Department of Applied Economics at the the University of Minnesota. His research interests were focused on the spatial aspects of agriculture, and how we might better use spatial data to understand agricultural systems. He had a particular focus on the ways in which research investment patterns and natural environments (including pests, diseases, climate and weather) affect agricultural production and productivity, the spatial dynamics of production, and bridging the divide between biology and economics (bio-economics). Beddow worked for InSTePP since 2006, and held a B.S. degree from Texas Tech University, a M.Sc. degree from the Virginia Polytechnic Institute and State University and a Ph.D. from the University of Minnesota. He worked on the economics of agricultural pests and diseases, international research and development spillover potential, measuring the effects of weather on production, and the effects of location on productivity.
Curriculum Vitae (PDF)


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|Subject: Local Media Monitoring - July 14,
LOCAL MEDIA MONITORING
July 14, 200
1. The Deputy Commissioner of the Bobonaro's District, Mr Semedio Talo M., on Friday said that the Oeleu's community in the Sub District of Bobonaro had seen unidentified armed groups walked across their villages. Mr Talo said that last week there was a clash between groups identified as former militias and the community live near the border. Mr Talo said that the clash has resulted in one policeman's uniform tore by an arrow shot by unidentified person. And a man was arrested while the others escaped into West Timor. The article said that in order to pursuit the unidentified armed groups the National Police has carried out sweeping operation in close coordination with UN PKF from Australian Battalion in the areas of Oeleu, Saburai, Sasa and Atus in the Sub District of Lolotoe.
2. The UN POL Commissioner, Ms Sandra Presley, held a press conference on Friday to explain the fight among five aldeias in the Leolima's Suco, Sub District of Hato-Udo, District of Ainaro. Ms Presley said that 24 persons have been detained by the local police for questioning. Ms Presley said that the motive of the conflict is under investigation. (The article did not mention when the incident occurred).
1. Former Timor Leste's refugees in South Celebes Province of Indonesia on Friday filed the United Nations High Commission for Refugees and the Provincial Social Department to be responsible for the kidnapping of the East Timorese children from the "Mujahidin orphanage". The article said that 2 teenagers, Sebastiao Vasco or Fauzan (17 years old) and Celestino Alves or Muhaimin (15 years old) were returned to their home town in Timor-Leste by UNHCR few days ago.


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Bio-entity Coreference Resolution focuses on identifying the coreferential links in biomedical texts, which is crucial to complete bio-events’ attributes and interconnect events into bio-networks. Previously, as one of the most powerful tools, deep neural network-based general domain systems are applied to the biomedical domain with domain-specific information integration. However, such methods may raise much noise due to its insufficiency of combining context and complex domain-specific information.
In this article, we explore how to leverage the external knowledge base in a fine-grained way to better resolve coreference by introducing a knowledge-enhanced Long Short Term Memory network (LSTM), which is more flexible to encode the knowledge information inside the LSTM. Moreover, we further propose a knowledge attention module to extract informative knowledge effectively based on contexts. The experimental results on the BioNLP and CRAFT datasets achieve state-of-the-art performance, with a gain of 7.5 F1 on BioNLP and 10.6 F1 on CRAFT. Additional experiments also demonstrate superior performance on the cross-sentence coreferences.
The source code will be made available at https://github.com/zxy951005/KB-CR upon publication. Data is avaliable at http://2011.bionlp-st.org/ and https://github.com/UCDenver-ccp/CRAFT/releases/tag/v3.1.3.
Supplementary data are available at Bioinformatics online.


While revising a series of case studies for a global IT services company, I found myself asking them over and over:
- What did you do for your client that was different or better than what either the client or your competitors could have done?
- How did your work help your client’s bottom line?
These two seemingly obvious questions were often very hard for the “in the trenches” account and project managers to answer. But without that context, any case study is just a “so what?” list of tasks you accomplished. Here’s what’s worked for me in making these case studies matter to prospects.
Why We’re Better
Account and project managers are stuck in the weeds because they’re paid to meet internal processes and delivery goals. To them, implementing an application upgrade, server refresh or shift to an offshore location are successes in and of themselves. The business-level benefits (such as cutting software licensing costs, speeding problem resolution or reducing support costs) are often hammered out several layers above them and long before they started work.
As a result, when I ask “Why are you better?” I hear things like:
- “Global delivery of seamless service for database, compute, storage, network and applications…”
- “Performed on-time and on-budget migration of Microsoft Exchange 2003 to Exchange 2010, VPN upgrades, XP to Windows 7 and self-service password reset…”
- “In Q! completed offshoring of Level 1 and Level 2 services to Mumbai, Prague and the Philippines for 24/7 help desk coverage…
By repeatedly asking a) specifically what they did differently than others and b) the specific process-level benefits of their work, I can often drive them to cough up more useful details. For example:
- “Using our proprietary transition methodology, we provided global delivery of seamless service for database, compute, storage, network and applications…” in half the time competitors had promised in their proposal.
- Using our custom configuration scripts and customized server imaging tools, we “performed on-time and on-budget migration of Microsoft Exchange 2003 to Exchange 2010,
VPN upgrades, XP to Windows 7 and self-service password reset…” without interruptions to applications or employee productivity.
- The intensive pre-engagement training of our staff in the client’s systems allowed us, in half the time the customer expected, to “complete offshoring of Level 1 and Level 2 services to Mumbai, Prague and the Philippines for 24/7 help desk coverage…”
How It Helped
It’s also important to dig for quantifiable details about how the service engagement paid off to the business. The first time through, I’ll often hear vague descriptions such as:
- “Transformation of server, network and application pillars increased agility and optimized operational costs.”
- “Moving from siloed SLAs to a scalable business services model aligned IT and the business.”
- “Automation-related efficiencies led to reduced demand, greater performance and improved agility.”
By pushing for a) definitions of these terms and b) quantification of the business benefits we can come closer to something like:
- “Virtualizing the client’s servers, networks and applications allowed the client to scale their servers 2,000 percent to meet the holiday crunch. Our timely completion of a mobile app generated $2.5 million in additional revenue. Reducing the number of physical devices saved $125,000 in one time equipment upgrade fees and $50,000 a year in heating, cooling, space and management costs.”
- “Rather than siloed SLAs that track the performance of only part of the IT infrastructure, our business services model lets senior executives track how essential business services (such as order tracking and customer support) are operating. This lets them focus IT spending on the areas most critical to the business.”
- “Automation in areas ranging from password reset to server monitoring reduced the number of trouble tickets by 46%, increased availability from 97.6 to 99.99 percent, and made it easier to roll out upgrades to their CRM system.”
The earlier in the content production process you can get detailed answers like this, the sooner your internal, or external, writer can turn out compelling case studies. If you can’t get this quality of answer, ask yourself if it’s worth doing the case study at all.
Filed under: Content Marketing For IT Vendors
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Ghanaian songstress, Sister Deborah’s breakup with Medikal seems to still lurk on in her heart. The former lovers who were the top trending celebrity lovebirds sometimes back broke up in a rather bad way 3 years ago.
Medikal has moved on and is seemingly enjoying his love ride with Fella whom he has a child with having tied the note last year. Sister Deborah born Deborah Vanessa Owusu-Bonsu has also moved on but in a different direction where she sees love differently.
The singer feels love is a scam and money should be considered ahead of love. This, she decided to offer as advice to someone on Twitter who also probably has been ‘Medikalized’ after years of chasing love.
A Twitter user, @vee_theegoat tweeted saying: “I no longer believe in falling in love, I think it’s dumb.” And in reaction to that, Sister Derby commented, “e be scam sis, get money,” with a laughing emoji.
Source: Naomi Martey

domain: celebrity


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Bryce 3d is a old CGI program that still has some of the best terrain algorithms today.
Free to use and with a community that likes CGI in all the same way -- To make a creative digital setting. Rather if you want to create a picture to fool the human eye, create a CGI short film, or just learn how computers generate graphics using wire frames. Bryce is by far one of the most easiest to use and fun applications.
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ABC Contemporary Art Scholarship at Gachi Prieto
The Argentinian Gallery Gachi Prieto Gallery announces the opening of "Art, Resistance, Resilience", collective exhibition of the third edition of the ABC Scholarship, coordinated by Marcelo Pelissier, Lucas Marín and Claudio Ongaro Haelterman.
The American writer Herman Melville wrote a magnificent text about resistance and dissidence entitled "Bartleby, the scribe." The protagonist - a gray notary - from one day to the next before any order or requirement begins to respond "I would prefer not to do it" (I would prefer not to) and from then on he does not do anything. Bartleby interrupts the logic of capitalist production, and that is unforgivable. The story, of course, does not end well for him, Bartleby dies of inaction.
Bartleby is a dissident, a resistant - if not a melancholic - but his resistance is not transformed into resilience; It is a path of self-destruction.
The true artist is undoubtedly a resistant, someone who goes out of the norm, someone who does something outside the established, the crystallized, although, in our time, the imperatives of "professionalization" seek to incorporate it into logic From the market. The artist is a resistant and very particularly it is in countries like ours that often produces strong setbacks in the field of culture. Paradoxically, these setbacks reproduce exponentially the artistic manifestations, because the artist is a resistant and a resilient.
Art is then the key to resistance against a dehumanizing system, a meat grinder that leaves little standing. The artist's path is not that of Bartleby, because the artist chooses to do, but what he does is not what the system wants.
The seventeen young artists that make up this show are a clear example of optimism and resistance. They have not chosen the easy path, that of the production of what the system requires, nor that of inaction, they have chosen, as Don Juan de Castaneda would say, "a path with a heart", and that path will give them a dignified life.


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Welcome to my photography page!
For Christmas Peter bought himself an Olympus D-700, 4x-Wide, 12 megapixel camera. Then he was given two more by friends so the wonderful man gave it to me! *grins*
There are layers and levels of reasons why I love him.
So I have been taking pictures, playing with macro and distance.
The general consensus is that I need to work on my horizons but that I take beautiful pictures.
Most of the time they’re right about the latter but sometimes I tilt the horizon on purpose. They don’t believe me. 😀
I’ll be putting up my favourite photographs here from our weekly jaunts around the area. Most of them will probably be the beach and the weather, family and friends. If you wish to use a picture somewhere, please let me know. Most of the time I will give permission, as long as credit is given and I get a link back to it. I love it when people love my pictures.
Click on the photos to see them larger. They’re small because I’m adding several today.
This is the Grand Bend public beach in mid-January. It was the fiercest storm we’d had yet. I loved the view here of the storm along the beach and against the condos. Unfortunately, the wind was a bully and pushed me over just as I snapped the picture. I believe the camera was set on Auto (it changes the settings automatically based on the scene) and no zoom. I edited for the sepia tone.
Same day, standing in the same spot. I swear I was holding the camera straight. *laughs* Same settings on the camera. I upped the light a little bit when editing. It looks stark and cold, doesn’t it?
About 10 days later this is a causeway on a private beach – the beach is down 44 steps and is a challenge for me to get up from but I love it there. Unfortunately, that day I fell, twisted my hip and lower back and we haven’t been back since because we’re trying to let me heal.
This is about a month later, in late February. It’s on my morning walk (the second half, before I started riding again) and I loved the contrast of the white on brown and the lines of it against the blue sky. I don’t remember the settings here except that it was at max zoom. I didn’t change a thing when editing.
This is the same day and if you don’t click on any of the others, click on this one. (Right click > new tab, easier that way) This used to be a railway track. It was part of the Grand Trunk Railway line but now is a beautiful walking path. It is Peter’s favourite photo, I think.
As I said earlier, I’ve been playing with macros this month. The camera is set on Super Macro – which sets the lens distance and focus. This stone is about an inch and a half long. It looks like a foot so when I wrapped it in wire I had to attempt to make it look like it was wearing a sandal. *chuckles* It looks HUGE here doesn’t it? And the sand looks amazing.
There’s another macro shot I’d love to show you but I can’t find the picture. I’m hoping it’s still on my camera. I have a habit of deleting groups of pictures I’ve put on my camera. I don’t think I’ve cleared it recently but we’ll see.
I hope you enjoy my photos as much as I enjoy taking them! 🙂


Lenovo announces Moto X4 variant with 6GB of RAM for India
Motorola teased the launch of a new India-exclusive Moto X4 variant on its official Twitter account in early January, and on Monday, the Lenovo-owned company revealed the specifications, availability, and pricing of the new model.
It’s time to experience speed like never before! Just 3 more days till you can get your hands on the All New #MotoX4, with 6 GB RAM and a design as stunning as ever!
Available on @Flipkart and #MotoHubs, starting 1st February. https://t.co/Y6VVqZL1tJ pic.twitter.com/2tcltlb6Qj
— Motorola India (@motorolaindia) January 29, 2018
The most notable difference is the RAM, which has been bumped to 6GB of RAM from the original Moto X4’s 3GB/4GB. But in terms of other hardware, the new Moto X4 variant isn’t all the different from current-gen models. It has a 5.2-inch Full HD (1920×1080) IPS display and comes with 64GB of internal storage, with support for expandable storage up to 2TB via a microSD card slot. It’s got a 2.2GHz octa-core Qualcomm Snapdragon 630 system-on-chip and a 3,000 mAh battery onboard that supplies a “full day’s worth” of power. And Motorola says it comes with Android Oreo out of the box, which isn’t too surprising considering the Oreo soak tests the company has been conducting around the globe.
Other features of the new Moto X4 include IP68 water- and dust-resistance, which means it can withstand up to 1.5 meters of water for 30 minutes; a 12 MP + 8 MP dual camera system; and the ability to stream audio to up to four devices simultaneously. To round it all off, the new Moto X4 also has Motorola’s suite of custom Android software features, such as Moto Voice, Moto Access, Attentive Display, and one-button navigation.
The upgraded Moto X4 will be available from Flipkart from February 1 at a price of Rs 25,000 ($392.75). As of right now, Super Black is the only confirmed color configuration. A wide variety of EMI options are available for the smartphone, and customers with an Axis Bank Buzz Credit Card are eligible for a 5 percent discount.


Den nye Skoda Enyaq Coupe vil komme med fire effekt-optioner, der spænder fra 132 kW til 220 kW og med mulighed for valg af enten bag- eller firehjulstræk.
Thomas Schäfer, ŠKODA AUTO CEO, says: “Following the successful launch of the SUV, the new ENYAQ COUPÉ iV brings even more emotiveness, sports styling and elegance to the ŠKODA iV family. Our designers and engineers have once again succeeded in combining a high degree of functionality with an emotive design. The brand-new range-topping model is also the first-ever all- electric ŠKODA RS. The ENYAQ COUPÉ iV perfectly combines emotion with efficiency, offering the ŠKODA-typical generous amounts of space, even in a particularly elegant body.”
Læs også: Skoda Octavia A8 Combi iV RS
The new ŠKODA ENYAQ COUPÉ iV and the ENYAQ iV are produced at ŠKODA’s main plant in Mladá Boleslav, making them the only MEB-based Volkswagen Group vehicles in Europe to be built outside of Germany. Due to its composition and a long wheelbase, the MEB modular electric car platform enables new options in terms of body proportions and design. As the high-voltage battery for the drive system is fully incorporated into the underbody, and because electric vehicles don’t have a transmission tunnel, the space available for rear-seat passengers is also particularly generous.
Du kan finde flere detaljer om den nye Skoda Enyaq Coupeover på Skodas hjemmeside via linket nedenfor, men der er endnu ingen detaljer om prissætninger.
Kilde & Billedrettigheder: Skoda


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🎉 Summer Camp at the lake!
Aug 21, 2021
Summer 2021 Songwriters Retreat!! Our Summer Camp at Sandy Cove included 4 days of writing and one full day of boating and R&R on the lake :) Songwriters included: Jeff Carl, Tolan Shaw, Ethan Rose, Marie Hines, Hera Lynn, Livy Jeanne, Kipp Williams, Ben Bishop, and Evan Coffman. Huge thank you to the music supervisors who flew in to work with our writers here in Nashville: Mike Lynn and Joanna Starling.
Watch the highlight video below!
The song in the video is "Good Life" – written and recorded at the camp by Marie Hines, Jeff Carl, and Kipp Williams.


Medium Specs: 10" overall length, 5.5" cutting edge, 1" thick.
Full Specs: 12.75", 7.5" cutting edge, 1" thick.
Made from our safety orange, high density rubber foam. This training knife replicates the Cold Steel Warcraft Medium and Full sized knives. Shock absorbing tip and slightly flexible/ compressible blade edge will allow you to train harder and safer. Steel rod installed in grip area creates a solid realistic connection while allowing the blade and rear to flex.
10.4"" overall length, 5.6" cutting edge, 1" thick. Made from our safety orange, high density rubber foam. Double bevel design replicates the top & bottom sharp edge. The Szabo Express Compressor has a steel rod in the grip for proper...
5.6" overall length, 2.3" cutting edge, 1" thick. Designed by John Benner, founder and owner of Tactical Defense Institute. Similar to KA-BAR TDI. Made from our safety orange, high density rubber foam. Tip shock absorber designed to flex on jab or...
The Compressor Draco series was developed with the evaluation by several "Force On Force" groups that wanted a heavy duty, safer, & battle ready trainer. During development, it was discovered that different lengths were desired depending upon application. Therefore, TAK developed 3...


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The opening will be witnessed by Tunisian ambassador in Cairo, Mohamed Ben Youssef, and a group of Arab and foreign playwrights.
Head of the Theater Art House Ismail Mukhtar, said that the performances of the Theater Art House will return to its theaters again, starting January 7, which coincides with the celebrations of Christmas.
The Youth Theater Group held the graduation ceremony of the two batches of “Ebdaa Helmak” (Start Your Dream) workshop at the Floating Theater in Manial.
Minister of Culture Inas Abdel Dayem is set to inaugurate Cairo’s Floating Theater on April 11 at 7 p.m.
Minister of Culture Inas Abdel Dayem will inaugurate the floating theater in Manial on April 4 in the presence of a number of stars.


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Song comes from Mars' second album 'Unorthodox Jukebox'
New book showcases his unique collection
The musician shows off the spooky toys that inspired his new book
Sneakers celebrate 30th anniversary of band's first album
Singer will also serve as musical guest on October 20th
Pop star spins her first rap track at Mugler event
'Family Guy' creator anchored 'SNL' season premiere
Promoting Guns N' Roses' upcoming Las Vegas residency
Singer plays 21 songs in about 85 minutes
Singer teams with 'Rolling in the Deep' co-writer Paul Epworth
Jakob Dylan and company seek solace on new track
Watch two icons duet on 'Foreign Window' and 'One Irish Rover'