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p27 binds and inhibits cyclin-CDK to arrest the cell cycle. p27 also regulates other processes including cell migration and development independent of its cyclin-dependent kinase (CDK) inhibitory action. p27 is an atypical tumor suppressor–deletion or mutational inactivation of the gene encoding p27, CDKN1B, is rare in human cancers. p27 is rarely fully lost in cancers because it can play both tumor suppressive and oncogenic roles. Until recently, the paradigm was that oncogenic deregulation results from either loss of growth restraint due to excess p27 proteolysis or from an oncogenic gain of function through PI3K-mediated C-terminal p27 phosphorylation, which disrupts the cytoskeleton to increase cell motility and metastasis. In cancers, C-terminal phosphorylation alters p27 protein–protein interactions and shifts p27 from CDK inhibitor to oncogene. Recent data indicate p27 regulates transcription and acts as a transcriptional coregulator of cJun. C-terminal p27 phosphorylation increases p27-cJun recruitment to and action on target genes to drive oncogenic pathways and repress differentiation programs. This review focuses on noncanonical, CDK-independent functions of p27 in migration, invasion, development, and gene expression, with emphasis on how transcriptional regulation by p27 illuminates its actions in cancer. A better understanding of how p27-associated transcriptional complexes are regulated might identify new therapeutic targets at the interface between differentiation and growth control.
p27 Is a Ubiquitously Expressed Cell-Cycle Inhibitor
The CDKN1B gene encodes p27, a cyclin-dependent kinase inhibitor (CDKi) of the kinase inhibitory protein (Kip) family. CDKis mediate cell-cycle inhibition. p27 is ubiquitously expressed and integrates mitogenic and growth inhibitory signals to govern normal cell-cycle progression (1). p27 can inhibit the catalytic activity of cyclin D-, E-, A-, and B-CDK complexes (2) by interacting with both cyclin and CDK subunits via its N-terminal domain, which is conserved among Kip family members (p21, p27, and p57; refs. 1, 3).
Antiproliferative and differentiation signals increase p27 to mediate cell-cycle arrest (2, 4–7). In normal cells, p27 levels are tightly regulated across the cell cycle. An increase in p27 by 2- to 3-fold is sufficient to fully inhibit G1–S-phase cyclin-CDKs (8). In G0-phase and early G1-phase, p27 protein translation and stability are maximal (9–13) and it inhibits cyclin E-CDK2 (2, 14). A progressive decline in p27 is required to relieve the inhibition of cyclin E- and cyclin A–bound CDK2 and enable transcription of genes required for G1- to S-phase progression (1). Transient C-terminal p27 phosphorylation by PI3K/AKT in mid-G1-phase facilitates assembly and nuclear import of D-type cyclin-CDKs (15), permitting their activation (3, 15, 16). p27 proteolysis increases during G1-phase progression via a number of mechanisms. Phosphorylation at p27T187 by cyclin E or cyclin A–bound CDK2 triggers p27 turnover by promoting its polyubiquitination and degradation by the SCFSkp2 ubiquitin ligase complex [S-phase kinase associated protein 1 (SKP1)/Cullin/F-Box protein: SKP2; refs. 17–19]. But how does the target kinase, cyclin E–bound CDK2, phosphorylate its own inhibitor? In G1-phase, Src family kinases phosphorylate p27 in its CDK inhibitory domain at Y74, Y88, and Y89 (20, 21). Phosphorylation of p27Y88 within the 310-helix that binds the ATP pocket in CDK2, leads to ejection of p27 from the catalytic cleft of CDK2, permitting kinase activation (20, 21). CDK2 can then phosphorylate p27 at T187 to trigger p27 proteolysis at the G1–S-phase transition. p27 is also degraded independently of T187 phosphorylation (see Fig. 1A). In early G1-phase, p27 phosphorylation at S10 (22, 23) leads to its export to the cytoplasm. Cytoplasmic p27 can be ubiquitylated by the ubiquitin ligase Kip1 ubiquitylation-promoting complex to mediate its degradation (24).
p27 Acquires Novel Functions through C-terminal Phosphorylation by PI3K Effector Kinases
C-terminal p27 phosphorylation regulates p27 function. PI3K promotes growth, survival, and motility (25–27) of both normal and cancer cells (28). PI3K activates downstream kinases, including AKT, SGK, 70 kDa S6 kinase (p70S6K), and 90 kDa ribosomal S6 kinase (p90RSK; refs. 26, 27, 29). These in turn phosphorylate p27 at T157 (30–32) to delay p27 nuclear import (30, 33) and at T198 (34, 35) to stabilize p27pT157pT198 (hereafter p27pTpT; refs. 36, 37).
p27 plays cell-cycle–independent actions to regulate cell motility (38, 39). Early work showed transduction of p27–TAT fusion protein into HepG2 cells increased cytoplasmic p27 and promoted cell migration (40). When p27null mouse embryo fibroblasts (MEF) were found to have impaired cell motility, this led to the discovery that p27 binds and inhibits RhoA-ROCK, leading to destabilization of the actin cytoskeleton and increased cell motility (38, 39). This p27 action is independent of cyclin/CDK binding, because the motility of p27null MEFs is restored equally by either WTp27 or by a p27CK− mutant that cannot bind cyclins and CDKs (38, 39). p27 phosphorylation at T198 promotes its interaction with RhoA and RhoA-ROCK1 inhibition (41, 42) to drive cell motility. While the precise role of p27-mediated cytoskeletal changes in normal cells are not fully known, these might serve to remodel cell shape in G1-phase to permit later changes during mitosis and cytokinesis.
p27 is also expressed in cortical neurons and neuronal progenitors and regulates interneuron migration. p27 plays roles in neuronal development and axonal transport via several mechanisms. Defects in the kinetics of nucleokinesis and tangential neuronal migration were observed in p27null mice (43), potentially through loss of p27/RhoA binding. p27 also promotes neuronal microtubule polymerization during neurite outgrowth (44, 45). p27 also appears to bind and stabilize alpha tubulin acetyl transferase 1 to promote microtubule acetylation and stability to regulate axonal transport (46). In addition to its effects on cell motility, p27 plays a number of roles that are independent of CDK inhibition to regulate autophagy, apoptosis, stem/progenitor fate, and cytokinesis (37, 47, 48).
Loss of CDK Inhibition by p27 in Cancers
p27 loss through decreased synthesis and excess proteolysis
Oncogenic activation of the SRC, MAPK, and PI3K signaling pathways deregulate p27 in cancers (1, 49). While high nuclear p27 levels restrain normal cell proliferation (50), p27 is nearly always deregulated in cancers (20). Human cancers often show reduced nuclear p27 (50–53) and this is associated with poor patient prognosis (1). This occurs predominantly through activation of SCFSKP2-dependent p27 proteolysis (17, 24, 36). Activation of ABL, LYN, LCK, and FYN in lymphoma and other hematopoietic malignancies also promotes p27 proteolysis (54). In addition, SRC activation (20) and ERBB2 amplification (55) are associated with reduced p27 in human breast cancer. p27 loss in human cancers can also result from oncogenic overexpression of miRNAs that impair p27 translation (reviewed in ref. 12). p27 is a key target of the miR-221/222 in multiple malignancies including glioblastoma (56, 57), triple-negative breast (58), hepatocellular (59), and papillary thyroid carcinoma (60). Other miRNAs also target p27 including miR-196a in cervical cancer (61), miR-24 in prostate cancer (62), miR-152-3p in chronic myelogenous leukemia (63), miR-148a in myeloma (64), and miR-199-a in osteosarcoma (65). p27 translation can also be regulated by long noncoding RNAs via ribonucleoprotein complexes (66), but the relevance of this mechanism to p27 loss in cancers is not known.
Constitutive C-terminal phosphorylation via oncogenic PI3K pathway activation
The PI3K pathway is oncogenically activated in a majority of human cancers (28). PI3K/AKT-activated cancers have constitutively C-terminally phosphorylated p27 that accumulates aberrantly in both the cytoplasm and nucleus and binds novel proteins to drive tumor progression (30–32). We and others showed AKT can phosphorylate p27 (30–32), impair nuclear import, and a highly stable p27 accumulates in the cytoplasm in PI3K-activated human breast cancers and is associated with poor patient outcome (30, 67). Cytoplasmic p27 was also observed in cancer models with oncogenic activation of Ras, PKC, or Pim kinases (68–71). Notably, PI3K inhibition restored nuclear localization of p27 in a K-Ras–activated lung cancer model (72). Cytoplasmic p27 is associated with increased metastasis and poor survival in a number of cancer types (1, 67). Indeed, overexpression of p27CK− coupled to a triple-nuclear export signal increased melanoma metastasis in vivo, suggesting p27 might have oncogenic actions independent of CDK inhibition (73). Activation of AKT/PI3K and accumulation of p27pTpT has been shown to increase tumor metastasis in several cancer models including breast and urothelial cancers (74–76). While the oncogenic action of C-terminally phosphorylated p27 was initially thought to result from cytoplasmic mislocalization (30), increased cyclin D-CDK4 assembly (3, 15) or RhoA/ROCK1 inhibition and cytoskeletal changes causing greater tumor invasion (38, 39), recent work has identified additional p27pTpT-interacting partners and novel oncogenic actions (see Figs. 1B and 2).
Increasing data indicate that p27pTpT acts as a transcriptional regulator to drive metastasis (75, 76). When p27pTpT accumulates due to PI3K activation, it associates with transcription factors STAT3 (75) and cJun (76) to drive transcription programs of epithelial–mesenchymal transition (EMT) and metastasis (reviewed below). cJun is a known regulator of tissue morphogenesis and multi-organ tissue differentiation (77). The finding that p27-cJun–driven genes govern developmental processes may illuminate work from 20 years ago that implicated p27 as a regulator of tissue differentiation in normal development. Before actions of p27 as a transcriptional regulator are discussed, we will briefly review lessons from mouse models on p27 action in differentiation and development.
p27 Plays Cyclin-CDK–Independent Roles in Development
p27−/− mice have a phenotype of gigantism due to multi-organ hyperplasia, and maldevelopment of retina, central nervous system, pituitary, and ovary (78–80). This has been attributed to failure to arrest the cell cycle during differentiation (78–80). Mice lacking p27 uniformly exhibit tumor formation in the pituitary (78–80); and haploinsufficient animals are carcinogen sensitive (81). Spleen and thymus enlargement in p27-null mice are associated with an expansion of committed hematopoietic progenitors of granulocytic and erythroid lineages, without increase in pluripotent hematopoietic stem cells (80, 82), and spontaneous T-cell lymphoma emerge in 6%. p27−/− mice also show maldevelopment of neural structures, retina, and pituitary, and pituitary adenoma cause premature death of nearly all mice at approximately 10 months (78–80). Notably, knockin of a cell-cycle defective p27 mutant that cannot bind cyclin or CDKs (p27CK−) failed to correct the large animal size, providing additional support for the notion that the CDK inhibitory function of p27 somehow coordinates stem/progenitor expansion in various tissues with cell-cycle arrest at differentiation (83). Furthermore, some developmental defects of the p27-null phenotype were corrected in the p27CK− knockin, indicating that some developmental actions of p27 are CDK independent (83). The p27CK− knockin mice showed stem cell expansion, hyperplasia, and neoplasia in the lung, not seen in p27−/− and a greater frequency of hyperplasia of pituitary, adrenal, spleen, and thymus and more T-cell lymphomas (20%; ref. 83). The widespread differentiation defects and increased progenitor self-renewal in multiple tissues, suggested p27CK− expression without cell-cycle restraint might misregulate progenitor/stem cells. The developmental phenotypes of p27-null and p27CK− knockin mice were initially interpreted in light of p27′s known CDK inhibitor action. However, CDK2 loss did not compensate the p27null phenotype in the double knockout (84, 85) and subsequent studies soon showed further evidence for CDK-independent p27 actions in differentiation.
The p27 homologue in Xenopus, Xic1, is required for normal muscle (86, 87) and neuronal differentiation (88–90). This prodifferentiation function is cell-cycle independent (86, 87), because Xic1 is required prior to growth arrest during differentiation and because a mutant xic1, which cannot bind cyclin-CDKs, can compensate for Xic1 loss to promote differentiation. p27 interacts with several transcription factors either genetically or physically to govern differentiation. p27 interacts in a cyclin-CDK–independent manner with Nrf2, and binds and stabilizes Neurogenin 2 to regulate neuronal development in both frogs and mice (88–90). p27 cooperates with myogenic transcription factor, MyoD (86), to drive myogenesis (86, 87). p27 is also involved in the maintenance of muscle stem cells (MuSC). p27, together with the upstream activator AMPK, prevents apoptosis of aged MuSCs by enhancing autophagy (91). p27 also interacts functionally and genetically with transcription regulator, p130, to promote endochondral ossification (92). In keratinocyte precursors, antisense oligonucleotides to p27 disrupted the expression of differentiation markers but did not prevent growth arrest, indicating that normal keratinocyte differentiation is p27 dependent but does not require its CDK inhibitory action (93). Taken together, these findings indicate that p27 controls cell proliferation and organ size (78–80) through both cell-cycle–dependent and -independent mechanisms to regulate normal tissue progenitor expansion and differentiation. Because the p27null phenotype was not compensated by CDK2 knockout (84, 85) and some developmental defects in neurogenesis and myogenesis of p27null tissues can be compensated by expression of p27CK− (86, 88, 90), it appears that p27 has developmental actions independent of its cyclin-CDK binding. In the section below, we review emerging data that indicate a novel role for p27 in regulation of transcription. The developmental defects and organ overgrowth of p27null mice might reflect a normal role for p27 to govern gene programs that restrain tissue stem or progenitor cell self-renewal during differentiation and to integrate this with cell-cycle arrest.
Evidence for a Role for p27 as a Transcriptional Corepressor
Increasing data suggest that some of the developmental effects of p27 might result from novel actions on transcription (see Figs. 1B and 2). A limited genomic survey using chromatin immunoprecipitation (ChIP)-on-chip in quiescent MEFs showed p27 binds gene promoters as a putative corepressor with p130, E2F4, HDAC1, and SIN3A (94). Comparison of p27-annotated sites with genes differentially expressed in G0-phase wild-type (WT) MEFs versus p27null MEFs indicated that p27-target genes regulate splicing, mitochondrial function, translation, and cell cycle. Notably, interaction of p27 with p130 required the C-terminal portion of p27 and further assays support a model in which p130 recruits p27 to DNA and p27 is required to nucleate E2F4 and other corepressors (94).
It is not clear whether some transcriptional effects of p27 involve interaction with cyclin-CDKs. p27 recruitment to two putative repressed gene targets AURKA and MED18 identified by ChIP-on-chip (94), was evaluated across the cell cycle (95). At both sites, p27–promoter interaction decreased as p27 levels declined during progression from G0-phase to mid-G1-phase in synchronized NIH3T3 cells (95). ChIP-PCR also demonstrated individual recruitment of each of cyclins D2, D3, and CDK4 to the sites of p27 association, peaking in mid-G1-phase. Interactions of cyclin D2, D3, and CDK4 with these promoters decreased with p27 knockdown and were not restored by transfection of p27CK−, suggesting a need for D-type cyclin and CDK4 binding to p27 for their recruitment to chromatin. While these data raise the intriguing possibility that some transcriptional roles of p27 might involve cyclin-CDKs, further work is required to establish whether p27-dependent D-Cyclin-CDK4 recruitment reflects a tripartite complex at these promoters and whether these complexes indeed regulate target gene expression (95).
Further evidence for a role for p27 in gene repression came from MEFs and embryonic stem (ES) cells. p27−/− MEFs cells were shown to have higher basal expression of SOX2, suggesting p27 might act as SOX2 repressor. Sox2 is a critical ES cell transcription factor that maintains ES pluripotency and self-renewal (96) and drives stem cells in many different cancers (97, 98). SOX2 has an intronic regulatory element (SRR2). p27 interaction with this SOX2-SRR2 and each of p130, E2F4, and SIN3A led to SOX2 repression (99).
A genomic survey in G0-phase–arrested MEFs showed p27 is recruited to chromatin at consensus motifs of several other developmentally important transcription factors including PAX5 and MyoD, and p27 was shown to coprecipitate with each of these factors (100). p27 showed greater recruitment to distal putative intronic-binding sites compared with promoter proximal sites in G0-phase MEFs. Gene ontology analysis of protein coding p27 targets showed enrichment of pathways governing cell adhesion, differentiation, transcriptional regulation, and morphogenesis among others (100). Further work in growth arrested HCT116 colon cancer cells, showed up to half of p27-associated protein-coding gene targets were also sites of recruitment of p300/CBP-associated factor (PCAF). Correlation of ChIP-sequencing with gene expression following knockdown of each of CDKN1B and PCAF suggested that p27 acts predominantly as a PCAF corepressor to decrease target gene expression (101).
In p27null mice, p21 levels are increased and p21 appears to compensate for some cell-cycle defects of p27 loss (78–80). A recent report suggests that p27 downregulates expression of the p21 gene, CDKN1A, by repressing PITX2, a transcriptional activator of CDKN1A. Both CDKN1A and PITX2 expression were increased in p27−/− MEFs compared with WT MEFs. ChIP-PCR showed p27 recruitment to the PITX2 enhancer in association with loss of PITX2 expression and loss of p21. E2F4 was also recruited to this PITX2 site and E2F4 depletion also increased PITX2 expression supporting a model of p27-E2F4–mediated PIXT2 repression (102).
In a mouse model of K-Ras–driven pancreatic cancer, loss of p27 accelerated tumor development and decreased survival. Pancreatic acinar cells in p27−/− mice showed a disruption of apical basal polarity, premalignant acinar to ductal metaplasia, and reexpression of ductal progenitor markers, including Sox9. In the K-Ras–activated pancreatic cancer line, PANC1, WTp27 was shown to be recruited to the SOX9 promoter and to decrease its promoter activity in reported assays (103). The recruitment of corepressors was not characterized. The oncogenic cooperation between K-Ras and p27 loss was attributed in part to de-repression of SOX9 (103).
These studies, taken together, provide a body of work supporting a role for p27 in transcriptional repression of pathways governing cell adhesion, differentiation, and development. However, most of the studies above have provided little or no data to demonstrate the functional significance of p27-driven gene repression in vivo. The changes in pancreatic acinar polarity in p27−/− mice and more rapid emergence of p27−/− X-mutant K-RAS–driven pancreatic cancer were associated with, but not shown to be caused by, loss of SOX9 repression by p27 (103). In the case of SOX2 repression, p27null MEFs more readily undergo induced pluripotency due to higher endogenous levels of SOX2 expression (99). However, the functional consequences of p27-mediated transcriptional repression of SOX9, SOX2, or other gene targets in vivo in development and cancer have yet to be demonstrated.
Oncogenic Partnerships between p27pTpT and Other Transcription Factors
p27 activates STAT3 to mediate TWIST1 induction, EMT, and metastasis
In MCF12A human mammary epithelial cells, a CDK-binding defective p27pT157pT198-phosphomimetic, p27CK-DD, induced EMT, but the p27CK− allele lacking these phosphomimetic mutations did not (75). A comparison of sister breast cancer lines with low and high metastatic ability, respectively, showed the highly metastatic lines had activated PI3K and high p27pTpT (67). p27 depletion mimicked mTOR inhibition and abrogated the excess bone metastasis in the MDA-MB-231-1833 model compared with parental MDA-MB-231 (67). C-terminally phosphorylated p27 was shown to activate gene programs of EMT: in highly metastatic breast and bladder cancer lines, p27 depletion reduced expression of EMT transcription factors including TWIST1 and TGFB2, decreased activated STAT3 (pSTAT3), and reduced invasion and lung metastasis (75). In contrast, p27CK-DD transduction into low metastatic breast and bladder cancer cell lines activated pSTAT3, to upregulate TWIST1 and increase lung metastasis in vivo. Proteome analysis of 747 primary breast cancers showed p27pT157 levels correlated strongly with p27pT198, and with both pSTAT3 and PI3K activation (75). Thus, PI3K activation leads to increased p27pTpT to drive p27/STAT3 association, STAT3 activation, and STAT3-induced TWIST1, EMT, and metastasis (75). Further analysis of p27–STAT3 partnerships in transcriptional regulation is in progress.
p27 binds and transcriptionally coregulates cJun to drive programs of tumor progression
A recent study revealed a novel oncogenic cooperation between PI3K and cJun pathways: p27 phosphorylation by PI3K-activated kinases stimulates p27 association with cJun. p27 and cJun were shown to be corecruited to chromatin, leading to activation of transcription programs of cell motility and EMT to drive tumor metastasis (76). p27 thus emerges as a novel cJun coregulator, whose chromatin association is governed by C-terminal p27 phosphorylation. In cancer cells with high endogenous p27pTpT or expressing p27CK-DD, cJun was activated and interacts with p27. p27–cJun complexes colocalized to the nucleus as shown by coprecipitation in fractionated cell lysates and proximity ligations assays. Sequential ChIP-qPCR with anti-cJun and re-ChIP with anti-p27 antibodies showed both are corecruited to TGFB2 to drive its expression. Comparison of global p27 and cJun chromatin association with gene expression showed p27 and cJun are corecruited broadly to chromatin and, in highly metastatic cancer models, upregulate target genes critical for cell adhesion, cytoskeletal regulation, TGFβ pathway activation, and oncogenic signaling. The most frequent transcription factor consensus motif bound by p27 was AP1/cJun, but other developmentally important and growth regulatory transcription factor binding motifs were also observed. Evaluation of binding within 5 Kb of transcription start sites showed p27-cJun target genes were differentially regulated, either up or down in the highly metastatic versus low metastatic lines. C-terminal p27 phosphorylation increased its interaction with cJun and cJun-p27 corecruitment to chromatin.
Profiles of target genes repressed by p27-cJun suggest p27pTpT might repress differentiation pathways. Over half of cJun-binding sites were cooccupied by p27, and cJun recruitment appeared to be p27 dependent, because cJun recruitment to a majority of cooccupied chromatin sites decreased dramatically with p27 depletion. Metastasis of orthotopic mammary tumors was markedly reduced by either p27, JUN, or TGFB2 depletion in the highly metastatic lines, showing the functional importance of p27-cJun–driven gene programs to metastasis (76). Finally, human breast cancers with high p27pT157 protein showed differential expression of p27-cJun target genes compared with cancers with low p27pT157. Both high p27pT157 and upregulation of p27-cJun targets were prognostic of poor patient outcome, underlining the biologic relevance of p27/cJun-driven gene programs to disease progression (76).
Our perspective of p27 deregulation in cancers has been expanded by the discovery of the novel roles of p27 in transcription. Disruption of p27 action can occur through excess proteolysis or miRNA-mediated loss of p27 translation, but also via other mechanisms. The oncogenic effects of p27 to disrupt the cytoskeleton and to upregulate the assembly and activation of D-type cyclins are not the only or potentially even major consequences of constitutive C-terminal p27 phosphorylation in the context of PI3K activation. Up to 60% of human cancers show some level of PI3K pathway activation (104). In addition to p27-mediated effects on the actin cytoskeleton in cancers, C-terminal p27 phosphorylation in cancers would lead to profound changes in gene expression programs, disrupting adhesion and activating EMT and other oncogenic gene programs to drive metastasis. Further work is required to understand the complexity of the transcriptional machineries that interact with p27 in normal development and malignancy.
Our understanding of the transcriptional roles of p27 is still in its infancy. In quiescent normal MEFs, p27 appears to partner with p130, E2F4 to recruit HDAC1, and SIN3A to restrain gene expression (94, 99). In cancer models, p27 can activate both STAT3 and cJun to promote gene programs of EMT and metastasis (75, 76). Indeed, p27-cJun complexes appear to play roles to both activate and repress target genes, but mechanisms governing gene selection and induction versus repression are not yet known. p27 has been shown to interact with MyoD, NRF2, PAX5, and cJun and other developmentally important transcription factors (see Figs. 1B and 2; refs. 76, 90, 100, 102). That p27 regulates gene targets governing cell migration and EMT also supports potential transcriptional roles during development. It will be of interest to determine how the transcriptional roles of p27 might govern differentiation in different tissues and contribute to the phenotypes of p27null and p27CK− mice.
The induction of broad pro-oncogenic gene programs by constitutive PI3K-driven p27–cJun interaction on chromatin targets offers a new explanation for the profound effects of p27pTpT on tumor metastasis. It will be of interest to determine whether changes in phosphorylation across the normal cell cycle govern changes in p27′s role in transcriptional regulation and whether any of these trans-regulatory completes involve associated cyclin-CDKs.
In normal cells, AKT is transiently, periodically activated in early G1-phase and this is associated with transient accumulation and loss of p27pTpT (15). This raises the possibility that cyclic C-terminal p27 phosphorylation might regulate periodic target gene selection and contribute to G1-phase progression. Further work in normal cell types will be required to evaluate how and which periodic phosphorylation of p27 at S10 in early G1-phase, T157 and T198 shortly thereafter in mid-G1-phase, and other sites might govern interaction with different transcriptional machineries to affect target gene expression or repression. A better understanding of how p27–cJun transcriptional complexes are regulated in normal tissue development and how these go awry in cancer might identify new therapeutic targets to be exploited for tissue regeneration and illuminate other aspects of human diseases, including cancer that arise at the interface of differentiation and growth control.
Disclosure of Potential Conflicts of Interest
No potential conflicts of interest were disclosed.
This work was funded by DOD BCRP grant number W81XWH-17-1-0456 to J.M. Slingerland.


MOSS ADAMS: Webinar 12/2 on internal controls to increase the value of your business.
AGENDA: 12/30 deadline to pre-register for Jan. 5-6 Long Beach show.
CIT TRADE FINANCE: Middle-market retailers cautiously optimistic for holiday.
Details on Industry Insight.
Next year, Surf Expo will move back its dates to Sept. 10-12 for its late summer show after surveying retailers who overwhelming said they prefer dates after Labor Day, according to Surf Expo.
Meanwhile, ASR dates will move dates earlier to Aug. 14 -16.


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According to FINRA, Robert Gleason, (CRD No. 222951 , Owensboro, KY) submitted an Offer of Settlement in which he was barred from association with any FINRA member in any capacity. Without admitting or denying the allegations, Gleason allegedly consented to the sanction and to the entry of findings that he may have engaged in sales practice violations in a customer’s account while he was employed at Ross, Sinclaire & Associates, LLC. According to FINRA, Mr. Gleason’s alleged unwillingness to provide testimony for the investigation prevented FINRA staff from reaching a determination as to whether the alleged violations occurred. By the foregoing, Gleason allegedly violated FINRA Rules 8210 and 2010.
For FINRA’s full findings see FINRA Case # 2015047887401
According to his FINRA BrokerCheck, Gleason was registered with Ross, Sinclaire & Associates, LLC in Owensboro, KY from 02/2009 – 09/2014.
The foregoing information, which is all publicly available on FINRA’s website, is being provided by The White Law Group. The White Law Group, LLC is a national securities fraud, securities arbitration, investor protection, and securities regulation/compliance law firm with offices in Chicago, Illinois and Franklin, Tennessee. For more information on the firm and it’s representation of investors, visit https://whitesecuritieslaw.com.
For a free consultation with a securities attorney, please call the firm at 1-888-637-5510.Tags: Robert Gleason attorney, Robert Gleason barred, Robert Gleason class action, Robert Gleason complaint, Robert Gleason investigation, Robert Gleason lawsuit, Robert Gleason Owensboro KY, Robert Gleason Ross Sinclaire and associates, Robert Gleason securities fraud Last modified: August 23, 2016

domain: news


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Despite the yearlong crackdown on terrorism in Xinjiang that has been steadily intensifying since its launch in May, violent incidents have continued to claim lives in the region. While Xinjiang authorities trumpet the smashing of 115 “terror gangs” and the arrests of 334 people [Chinese] after six months of the anti-terror campaign, Didi Tang reports that death tolls suggest violence may even be increasing in Xinjiang. From the AP:
“It’s safe to say that violence has continued roughly as it was before this latest crackdown, if not with greater intensity,” said Rian Thum, an assistant professor specializing in Uighur history at Loyola University New Orleans.
[…] Beijing blames the violence on separatist terrorists fueled by religious extremism and with ties abroad, and argues that it has invested generously to boost Xinjiang’s economy and improve its quality of life. Critics attribute the violence to home-grown disgruntlement over local corruption and an influx of Hans who have brought economic development that has not equally benefited Uighurs.
[…] A six-month report card on the campaign published on the Xinjiang government’s official news site this week focused on prosecution data. It said authorities detained 334 suspects and prosecuted 294 cases of sharing online terrorism-promoting audios and video, and seized 18,000 copies of illegal religious books.
[…] The report also cites as a major success the life imprisonment of a prominent Uighur scholar known for his open criticisms of China’s Xinjiang policies, although the September conviction of Ilham Tohti on the separatism charge has drawn international condemnation. [Source]
Last week, Ilham Tohti’s life sentence and separatism charges were upheld by a Xinjiang court, and this week seven of the scholar’s former students also stood trial for separatism.
At The Telegraph, Tom Phillips reports on authorities’ plans to recruit 3,000 former PLA troops to Xinjiang to further tighten security:
Xinjiang officials are now seeking former troops of “high political quality and military experience” to beef up security in the region, state media announced on Friday. Candidates should be under 30, have no criminal record and be “against separatism and illegal religious activities,” according to the Civil Affairs Bureau in Urumqi, the regional capital. Successful applicants will receive salaries of at least 3,000 yuan (£310) per month and help relocating.
[…] The initiative represented the latest phase in the “securitisation of Xinjiang with a clear focus on protecting the Han population,” said Dr James Leibold, a specialist on China’s ethnic policy from La Trobe University in Australia.
[…] During a recent trip to Hotan, a city in southern Xinjiang that has suffered repeated outbreaks of violence, Dr Leibold recalled seeing around 50 Han Chinese civilians dancing in a public square. Around them stood more than 70 armed police officers with machine guns.
“They just come when the Han come out to dance and when the Han leave, they leave too,” Dr Leibold said. “It was pretty weird.” [Source]
Tom Phillips reported in October on a project that sent 200,000 officials into the Xinjiang backcountry to simultaneously engage in PR efforts and gather intelligence on local Uyghurs (via CDT).
Meanwhile, after Turkey recently expressed a desire to provide shelter for hundreds of Uyghur refugees who were rescued from a human smuggling camp in Thailand in May, China’s Foreign Ministry has criticized Turkey for interfering in Chinese affairs:
Asked for a response on Turkey’s offer, China’s Foreign Ministry spokeswoman Hua Chunying said the case was a matter for China and Thailand and “the relevant country” should stop interfering.
“We urge the relevant country to immediately stop meddling in placement work for the relevant case, be cautious with words and actions and not send out mistaken signals that connive in, and even support, illegal immigration activities,” Hua said in a faxed statement to Reuters.
[…] Turkey is home to thousands of Uighurs who have fled Xinjiang since the Chinese Communists took over the region in 1949. It has projected itself as a stable Muslim democracy, a key player at a time of turmoil and unrest in the Middle East. [Source]


Even if we couldn’t, and even if we didn’t try to understand better and focus a bit more on Sweden’s pop music, the country’s artists have edged their way into the international scene over the last few decades, making them impossible to miss.
Despite monumental names and records on a different level that are not easy to ignore, the country’s residents don’t seem to suffer the “stardom virus” so intense in other societies. Yes, they love the big crowds and enjoy touring around like the other guys, but mostly they love making music to enjoy and dance to. And if success comes it’s welcome, but mostly it feels like a passion for making pop electronica or electro, rather than sitting down to write a song to hit the charts.
Ask Kite, ask Covenant, ask Red Zebra etc. how beautiful life is when they get invited around the world to perform their music for audiences that sing their songs. Out of this prolific scene comes to the new moniker ShapeShiftingAliens from Stockholm who published their new single and video, Showing My Face, early this month via Sublunar Society records.
The act is made up of two experienced guys who are heavily involved in the music industry: Niklas Rundquist, who also stands behind Brainshadow, was and still is in Leather Nun (violin here), and a composer of films, documentaries, and commercials, and Johan Cléve, frontman and guitar player who is also a producer and composer, live and studio musician who has performed with quite a few names. A skilled and talented duo which caught the interest of The Residents‘ Nolan Cook, with whom they collaborated in Shadows from their 2017 eponymous album.
The new single, Showing My Face, is the perfect specimen to get into that artistic and grotesque, indeed, perfectionist pop-alternative-electronica they offer to the dancing masses. Uptempo without raved-out beats, joyful, weird, and blended with that enormous Bowie-esque feeling all over–it feels like the band’s dedication to the Starman. You will notice for sure the influence of Reznor and Moby, but all of these elements work fine within the unique arrangements rolling strangely on an analog rail. Sharp sounds, neo-romantic melodies with a very special groove all over–that’s their art.
Here is ShapeShiftingAliens to catch one more Scandinavian breeze and applaud the outcome, skål!
Keep Up With ShapeShiftingAliens
Written by Mike D.


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Wordpress open source online website publishing software has just released its update on recent version also a beta of Wordpress 3.2.
AvantLink.com, the premiere Affiliate network in web retail, freshly rolled out an official Wordpress plugin. This plug-in permit Wordpress Affiliates to incorporate product ad campaigns, product search functionality, widgets and more from directly within content management system (CMS) admin panel.
Statcounter has reported that the Android OS (operating system) is now more commonly in use than the long-established Blackberry OS. The Android OS overtook its competitor Blackberry for the very first time in February; Statcounter said it registered a 15.2 percent of the worldwide user market.
The Joomla Community magazine has already been at its 9th issue and in the month of March it requests you to propose your comments in rhyme. Editor for the March issue is Dianne Henning and her opening, Inspiration, and the Winds of Change... indicates the reality that Joomla! 1.7 will be here in July.


Tube City Community Media Inc. is seeking freelance writers to help cover city council, news and feature stories in McKeesport, Duquesne, White Oak and the neighboring communities. High school and college students seeking work experience are encouraged to apply; we are willing to work with students who need credit toward class assignments. Please send cover letter, resume, two writing samples and the name of a reference (an employer, supervisor, teacher, etc. -- not a relative) to firstname.lastname@example.org. (4-11-2023 to 4-30-2023)
Ads start at $1 per day, minimum seven days.
Cherepko Faces Two Challengers for Re-Election
Campaign for Democratic nomination has included intrigue, social-media controversy
By Tom Leturgey
The Tube City Almanac
May 14, 2023
Posted in: McKeesport and Region News, Politics & Elections
The race for mayor of McKeesport has a great deal of intrigue, as voters will report to polling places in just a few days.
In many races throughout Allegheny County, including the race for mayor of McKeesport, there are no official Republican challengers. Barring a successful write-in campaign during November’s election, the winner of the primary will be sworn in as mayor.
McKeesport Mayor Mike Cherepko, 46, has been in office since 2012 and is hoping to secure the Democratic nomination on Tuesday. The Penn State University graduate was a fifth-grade teacher in the district before becoming an elected official. He touts his “Working Together for a Better McKeesport” as a successful motto.
In this year’s Democratic primary he faces two challengers who both emphasize their “outsider” status, Joe Lopretto, 58, a retired McKeesport police officer, and Corry Sanders, 52, a church deacon, barber and business owner.
All three candidates received an questionnaire with identical questions. In addition, reporter Tom Leturgey called Lopretto and Sanders on May 2 and May 12, and sent questionnaires to Sanders and Lopretto via their official Facebook pages.
Lopretto and Sanders did not respond to Leturgey’s phone messages or Facebook messages, though both have been using Facebook to share their campaign statements and positions.
McKeesport has about 17,700 residents as of the 2020 census.
Michael Cherepko: Mayor calls himself ‘fully invested’ in city’s recovery
In his last re-election in November 2019, Cherepko defeated independent Fawn Walker-Montgomery by roughly 65 to 35 percent.
Supporters have credited Cherepko for a number of positive accomplishments during his time in office, including demolition of hundreds of vacant houses, and creation of a six-year neighborhood partnership program, dubbed “McKeesport Rising,” with the Pennsylvania Department of Community Economic & Development to remove blight and stabilize neighborhoods.
The blight removal has also included the McKeesport Downtown business district, and the razing of the former G.C. Murphy Co. office and vacant storefronts.
Supporters also have credited Cherepko for his leadership following the fatal shooting of McKeesport police Officer Sean Sluganski on Feb. 6. In an open letter to residents, Cherepko wrote: “Officer Sluganski loved our community, too. His family knew McKeesport is a special place because of how Sean spoke about all of us. He loved serving this City and being a part of our community.
“Your incredible support allowed the Sluganski family to see firsthand just how special our community is,” the mayor continued. “The members of the Sluganski family are now honorary McKeesporters, by their own description. They have McKeesport in their hearts, just as we have them in ours.”
In his responses to Tube City Almanac’s questions, Cherepko said, “I am fully invested in the McKeesport Rising initiative and the logic that brought it to light.”
“Over the past five years, the McKeesport Rising project has allowed my administration to improve the quality of life for all McKeesporters — utilizing various revenue sources and opportunities to carry out improvements in infrastructure, neighborhood preservation, public safety, and economic development. It is a multi-faceted plan that approaches community development through these areas.
“We are preserving neighborhoods through demolition and home improvement, improving infrastructure through paving, advancing public safety through technology and outreach, recruiting local businesses, and increasing recreational opportunities,” Cherepko said.
He continued: “Through the public works and police departments, we made equipment purchases, including vehicles, machines, and advanced technology. Through community development, demolition contracts have allowed for the removal of more than 400 blighted structures, and nearly 300 more were placed under contract in 2022. This translates to better living conditions that have boosted the sense of morale throughout McKeesport’s 12 wards, and the improvements aren’t limited to neighborhoods.”
The “McKeesport Rising” project has included a partnership with a non-profit organization, Rebuilding Together Pittsburgh, to renovate owner-occupied homes for low-income residents. According to its website, RTP has completed 3,500 home repairs in 24 Allegheny County communities, including McKeesport.
During Cherepko’s time in office, Allegheny County Regional Asset District — or RAD — money has been increased for Renziehausen Park, and some $2.3 million from PennDOT has been secured to re-route the Great Allegheny Passage bike trail and renovate the Lysle Boulevard parking garage.
“Progress can be seen throughout our business districts and in our parks,” Cherepko said. “We are in the process of reviving neighborhood playgrounds and making significant improvements to Renziehausen Park’s many amenities. This year, crews have been working on the Lions Bandshell, Jimmy Long Field, dek hockey courts, and stormwater drainage along the walking trails and throughout the park.”
Cherepko also worked with Lt. Gov. Austin Davis — who was then a state representative — and state Sen. Jim Brewster to help rescue the LaRosa Boys & Girls Club. The mayor also has attended the crime-prevention community meetings hosted by the McKeesport unit of the NAACP.
“I have been working tirelessly with the McKeesport Police Department, the NAACP, and field experts in regional law enforcement agencies, the Healthy Village Learning Institute, the University of Pittsburgh, Allegheny County Department of Human Services, and more in effort to curb society’s addiction to crime and violence,” he said.
Joe Lopretto: Candidate says city needs a ‘change’
Joe Lopretto, 58, is a 16-year member of the McKeesport Area School Board and a retired police lieutenant who is running for mayor. Much of his campaign of “change” is operated via social media.
Lopretto also has been campaigning at major intersections in the city, including through the use of a mobile billboard truck.
Lopretto did not return phone calls seeking comment on May 2 or May 12. The identical questionnaire offered to Cherepko was offered to Lopretto via Facebook Messenger.
Lopretto is also a candidate for McKeesport Area School Board.
In messages posted on Facebook, Lopretto says that McKeesport needs new leadership, and he has been critical of those who have been in office for a long time.
As a police officer, Lopretto says he was involved in programs benefiting children, such as Drug Abuse Resistance Education (DARE) and the Junior Police Academy. He also participated in a Senior Police Academy for senior citizens in the city. He says his experience in law enforcement is what would make him more effective in fighting crime in McKeesport.
He told the Mon Valley Independent: “If you want a safer community, then elect someone who has a policing background. I am the only candidate with that experience. And I’m the only candidate who has served the city for over 23 years.”
In a recent Facebook post, Lopretto wrote that he filed a right-to-know request seeking names and salaries for all city employees, but was rebuffed by the city solicitor and administrator.
He believes that city funds have been squandered in a variety of ways. Lopretto has criticized Cherepko’s use of a city-owned car and says that he would forgo city-financed vehicles and would drive his own to work.
He told the Mon Valley Independent, “I’ll make sure every street is paved. And I will save the taxpayers money from day one.”
Lopretto alleges that his campaign signs have been stolen by political enemies or damaged by city work crews. His social media posts show Lopretto out in the community at firefighter fundraisers and McKeesport school activities.
Lopretto calls himself empathetic and outspoken, and says he wants to work to make McKeesport more attractive to businesses and families.
Corry Sanders: Says his goal is ‘changing and improving my community’
Corry Sanders, 52, is a deacon, barber and business owner who graduated from McKeesport Area High School in 1989.
Sanders did not return phone messages left on May 2 and May 12. The identical questionnaire offered to Cherepko was also offered to Sanders via Facebook Messenger. The message was not answered.
Sanders, the only Black candidate in the race, says his years of working and raising a family in the community allows him to see McKeesport and its challenges in a different light. According to the U.S. Census Bureau, McKeesport is about 53 percent white, 38 percent Black or African American, and 6 percent mixed-race.
Sanders is popular and outspoken and in 2016 won a seat on McKeesport City Council, but an Allegheny County judge ruled that he was ineligible to serve due to a 1993 drug conviction.
Sanders continued to work in his barber shop and volunteer at his church.
Following a successful appeal to the state pardon board and the efforts of then-Lt. Gov. John Fetterman and others, Sanders was pardoned by Gov. Tom Wolf in 2019.
He told the Mon Valley Independent: “I am an active member and deacon at my church. I’m a husband of 17 years and father of five. I’m a barber by trade. I’ve served in many capacities within the field.”
He continued: “I am no stranger to my community. A lifelong resident of McKeesport, I have sat on different business boards throughout the years. Politics was never a goal, however. Changing and improving my community is.
Sanders said he has seen the city’s decline first hand. He told the Mon Valley Independent that his three primary areas of concern are “community development, building the police department and streamlining the city budget.”
He said he wants more governmental transparency, would like more accountability — including a citizens’ police review board — and to hire more police officers. Like Lopretto, he also wants to cut what he calls unnecessary spending.
In recent weeks, Sanders has posted at least two campaign videos on social media touting his community involvement, along with photos promoting his students graduating from barber school.
Cherepko and Sanders have had public disagreements. In September of last year, the two had a tense exchange during a McKeesport City Council meeting.
Cherepko was dismissive off Sanders’ inquiries, saying “people do not understand how government works” and argued that Sanders talked about issues “based on no facts whatsoever.” Sanders retorted, “I’m not the mayor — yet.” Cherepko asked a police officer to remove Sanders from the podium, but he was allowed to stay for the rest of the meeting.
Less than two weeks later, Sanders was arrested and charged by the Pennsylvania Office of Attorney General on new narcotics charges, in connection with what then-Attorney General Josh Shapiro called a “major drug trafficking operation” that investigators allege was headed by Curtis M. Harper Jr., 52, of McKeesport.
Sanders is charged by the state attorney general’s office with two counts each of drug possession, possession with intent to deliver and delivery. Investigators allege that Sanders sold cocaine to a confidential informant on two separate occasions in November 2022.
According to court records, he was formally arraigned on the charges on April 18 and faces a pre-trial conference May 26 before Allegheny County Common Pleas Judge Alexander P. Bicket.
Sanders maintains his innocence and says that the charges are politically motivated.
Like Lopretto, Sanders also accuses political opponents of stealing or knocking down his campaign signs, including a banner on Eden Park Boulevard.
Tom Leturgey is a freelance writer based in Pittsburgh and the editor of KSWA Digest, the online news and features home of the Keystone State Wrestling Alliance. He usually covers the City of Duquesne for Tube City Almanac and was asked to write this story because he does not know any of the candidates.
Leturgey’s work also appears in The Valley Mirror and other publications.
Originally published May 14, 2023.
In other news:
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Pepper Potts Holds Onto A Roughed-Up Iron Man For Her IRON MAN 3 Character Poster!!
The Kidd here...
Another day, another IRON MAN 3 character poster with Marvel Studios giving Gwyneth Paltrow the solo treatment for her role as Pepper Potts in the next chapter of this franchise... and based off this imagery as well as what we saw with The Mandarin's character poster, some rough times lie ahead for Tony Stark in this summer's flick. Iron Man is going to get fucked-up, no question.
We all certainly wanted The Mandarin to arrive in Iron Man's branch of the Marvel Cinematic Universe, and it looks like he's coming in May in a big, big way.
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A Palestinian died in the occupied West Bank Thursday after being shot in the stomach by Israeli forces, the Palestinian health ministry said, in the latest bloodshed in the territory.
The ministry said 27-year-old Mahmud Fayez Abu Ayhour was killed in Halhul, north of the flashpoint city of Hebron. The Israeli army told AFP it was checking the circumstances of the incident.
The Red Crescent had earlier reported several injuries following unrest in Halhul.
In recent weeks, the Israeli army has been conducting near daily operations across the West Bank, making multiple arrests in what they describe as “counter-terrorism activities.”
The most recent operation, conducted overnight, involved nine arrests, the army said.
Nineteen people, mostly Israeli civilians -- including 18 inside Israel and a Jewish settler -- have been killed in attacks by Palestinians and Israeli Arabs since late March.
Israeli security forces have responded with raids inside Israel and in the West Bank, particularly in and around Jenin. Three Israeli Arab attackers and a police commando have died.
Forty Palestinians have been killed in the West Bank -- suspected militants but also non-combatants, including an Al Jazeera journalist who was covering a raid in Jenin and bystanders.
US mission to Palestinians renamed on Twitter, signaling possible upgradeThe Twitter account for the US diplomatic mission to the Palestinians in Jerusalem ... Middle East
The Palestine community that helps aspiring techies start a career with Google, MetaIn an environment where violence and instability haunt any prospect of a career, a ... Features
Israeli-Palestinian “flag war” brews as violence flaresFollowing weeks of violence in different parts of Israel and the West Bank, ... Middle East


Everything you need on Heat Pumps, including model details, industry rankings and customer reviews, all in one place.
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"My review on the Ramsond heat pump"
I have owned my Ramsond heat pump for about a year and I love it. I work at Home Depot so when I needed to replace my old one because the pump motor went out and it was a very old version they suggested many different ones but because I was on a budget I had to go with the Ramsond. Yes it is not the most top of the line one but it works wonders and we all love it. There were some reviews on it and they were some decent ones so that is another reason why I chose it. I would buy another one of the Ramsond not just because of the price but I like how it works. I would recommend it to my friends and coworkers even if they want to go with the name brands. It's funny how you don't realize there are so many brands of different things till you go and have to buy one.
Learn more about your home's heating and cooling system with our guides, how-to's, FAQ's, tips and more.


Most people have been affected by COVID-19 in some way, and many have experienced a reduction in income that may have caused significantly financial pressure on them. For those who rent their homes, whether through social or private rental agreements, the government put in place temporary legislation in England during the pandemic to help give tenants more security regarding evictions if they were to temporarily fall behind on paying their rent.
With these changes due to coronavirus, landlords are required to give at least six-months’ notice to tenants before starting eviction proceedings, apart from in certain circumstances. The exemptions include serious breaches such as anti-social behaviour, domestic abuse and rent arrears to the value of more than six months’ rent.
If you’re a landlord seeking expert advice on how to deal with a situation regarding tenants during the coronavirus pandemic, you can call our expert team for advice on 01616 966 229.


Topeak's HeadLux helmet light is the Siamese twin of bike lights. This one light does double duty with two super-bright LEDs facing forward and two red LEDs facing the rear. Its 3 modes and wrap around lenses ensure you'll be seen. A nice supplement to your regular light set, the HeadLux is a convenient way to add extra safety to your commute. Plus, batteries are included.
$49.99 - $54.99
An impressively bright dual-LED cycling light with a rugged machined aluminum body. Integrated cooling fins optimize performance and side cutouts provide side visibility. With up to 600 lumens of output and nine output modes, featuring a Daytime Flash mode, the Micro Drive 600XL is super-versatile—day or night. It offers up to 44 hours of battery runtime (nine hour increase) and charging is easy with an integrated cable-free USB stick. Its strap mounts securely to most bar sizes and shapes. Specs - Max Lumens: 600 - Weight: 97g - Max Runtime: 44 hours - Recharge Time: 2:30 hours
The Recon HL500 is the perfect multi-function light for use on handlebars or helmets. It features abundant light output in a lightweight design. - Lumens and runtime certified to the ANSI-Standard - Focused optics with side light design for over 270 degrees visibility - Heat-dissipating CNC-machined aluminum structure - Power status indicator can let you know how much run-time to go before powering off - Includes adjustable GoPro mount SPECIFICATIONS - Sizes: 85x26x34mm - Weight: 81g without mount - Colors: Black; Gray; Blue; Red - Output: 500 lumens - Runtime: High (500LM) 2hrs, Middle 4hrs (300LM), Low 10hrs (100LM), Flash 100hrs, SOS: 100hrs - Battery: Li-Ion polymer battery (2000mAh) - Waterproof: IPX6 - Certifications: ANSI-Standard FL-1
$4.00 $8.00 50% Off
Giant's Numen Mini Headlight is small, powerful, and surprisingly bright. It's so light, you can just leave it on your bars and you'll barely notice it, while drivers will notice its 2 bright LEDs as they illuminate your way. This nice light has a flexible rubber mount so you can attach it almost anywhere on your bike. It has steady and flashing modes and runs up to 100 hours on its included batteries.
PWR Rider is a 450 lumen bike light that can also be used as a power bank. Includes the option to program your brightness and runtime (through ModeMaker app), then use your remaining battery to charge your devices. The light outputs in an elliptical beam for broader, brighter road coverage; has a 2 hr runtime at max 450 lumens and 4 smart battery indicator LEDs to let the rider know how much charge is left in the light. The two “Charger” lights come with 5 pre-programmed modes, just in case you haven’t yet discovered the ModeMaker app. The PWR Rider will last 2 hours at 450 lumens, and for those with stamina, will run at 200 lumens for 5 hours. Program your modes: The ModeMaker app lows you to design the modes for any PWR bike light. Simply plug in your light, then select and tailor modes from the menu. You can do things such as control brightness, adjust runtimes and add new light modes. Charge your devices: Rear of the light is a USB rechargeable power bank. Use this to charge your phone, GoPro or cycle computer on the go. 1 hour riding @450 lumens means you can top up charge your iPhone by 35%. Charge time 3.5 hours. - Light output: 450 Lumens - Power bank: 2200 mAh - Dimensions: 122 x 30mm - Weight: 115g - What's in the pack: Light, Silicone Strap, USB Cable, Hex Key
- 10 watt, 650 lumen LED headlight - USB rechargeable 1100 mAh li-ion polymer battery - 6 modes including constant, boost, super bright, pulsating, daytime flash, and auto mode - Auto mode is environmentally responsive - Daytime flash mode enhances safety - Includes mounts for handlebars from 18-48mm and a GoPro style mount - Low battery warning and battery level indicator (double click button to check) - Tool free installation
PWR Road is a modular bike light. But it's not JUST another bicycle light. Not only is it a high power headlight, but simply take the product apart and you have much more. A lighthead for other PWR bike and camping lights, plus a PWR Bank to charge devices that is also the battery for all products in the PWR range. The PWR Road outputs a max 600 lumens, can run for up to 195 hours on Eco Flash mode, uses an elliptical beam for broader road coverage, can be mounted both on top or under the handlebar (mount under your Garmin), or your helmet, incorporates twist mode operation (turn the light on and off twisting the lighthead - no buttons) and gives you the option to program your brightness and runtime through our ModeMaker app. Functionality: Twisthead operation to turn light on / off and to scroll through light modes (no buttons) Charge your devices: Remove the light head and use the PWR bank to charge your phone, GoPro, cycle computer or other devices. 1 hour riding @600 lumens means you can top up charge your iPhone by 50%. Charge time 3.5 hours. - Light output: 600 Lumens - Power bank: 3350 mAh - Dimensions: 104 x 30mm - Weight: 125g - What's in the pack: Light, Power Bank, Side Mount, Gimbal Shim, USB Cable
- High-quality PREMIUM design - AWARD-WINNING light distribution technology - Easy-to-use LCD DISPLAY shows various information to the user - Extensive side lighting for INCREASED VISIBILITY AND SAFETY - MEMORY FUNCTION remembers the last mode used - Fully USB-RECHARGEABLE - NEW snap-tight bracket - 80 LUX - 6 Modes - Run time on Eco = 24 hrs - Run time on High Steady = 3 hrs
The All New NiteRider Lumina Dual 1800 represents the next evolution of our best-selling Lumina headlight into a dual LED set-up that produces a far-reaching beam pattern with extensive peripheral illumination; making it the ideal choice for any riding situation or terrain. The Dual emits an amazing 1800 lumens while in Boost Mode, making it one of the brightest self-contained bicycle lights available today. Simply double tap the power button to set the light to Boost Mode. When in Boost Mode, the power button will illuminate red and blue to notify the user at a glance. The Dual is also equipped with side lighting to increase your visibility day or night. Tested, meeting an IP64 rating; The Dual 1800 is designed to be used in a variety of riding conditions because of its high resistance to water and dust. Its high-strength Dupont Fiberglass reinforced nylon body casing and aluminum heat sink are engineered for extreme resistance to cracking and abrasion. - All New Collimator Lens, distributes a smooth widespread beam pattern - Side lighting for increased visibility day or night - Long lasting 20 hour runtime at 100 lumens in Walk Mode - 5 Light Levels plus 2 Daylight Flash Modes - FL1 Standard IP64, dust and water-resistant - Secure on and off-road capable handlebar mount - Fits standard and oversize 35mm handlebars - Helmet mountable (Helmet Mount sold separately) - Fast 3 hour charge via the included AC power charging adapter - Low battery indicator - Extend your ride time, 6 hour runtime at 350 lumens in Low Mode - Boost Mode indicator, power button will light up red and blue - Boost Mode, double tap power button to unleash maximum LED output at 1800 lumens! - Lock Mode, perfect for use during storage and transporting the light. Press and hold power button for 7 seconds to lock out operation of light. WARRANTY - The Lumina Dual 1800 is backed by NiteRider’s lifetime warranty that covers any defects in mechanical components (housings, covers, mounts and fasteners) and LEDs. SYSTEM INCLUDES - Dual LED Head Light - Internal Li-Ion Battery - Handlebar Mount fits up to 35mm - AC Power Charging Adapter
A powerful, multi-purpose front light with up to 1000 lumens of output. Its machined aluminum body with cooling fins is lightweight and super-rugged. It features eight output modes, with a class-leading 1000 lumen Daytime Flash mode. With its MOR (Maximum Optical Reflection) lens, light output is optimized and evenly dispersed. Battery runtime has increased by 11 hours for up to 87 hours of runtime. And its versatile strap securely mounts to variety of bar shapes and sizes. Remote Switch compatible. Specs - Max Lumens: 1000 - Weight: 153g - Max Runtime: 87 Hours - Recharge Time: 4 Hours
Make your presence known with this bright, versatile and compact LED light, perfect for when you need a light to be seen, rather than to see by. The 30 lumen Chip-On-Board (COB) LED light is easy to attach anywhere on your bike or helmet, without the need for tools. The Lumasense uses USB charging, so you can quickly and simply power up for the ride ahead. - USB rechargeable - 30 lumen COB LED - Tough nylon case - Multi-position mount - Silicone strap Burn Times: - Full power: 3.5hrs - Medium power: 6hrs - Flash: 8.5hrs - Strobe: 10hrs
FEATURES - Super Bright (120 Lumens) *Daytime Flash - Last Mode Memory - Auto Safe Mode - USB Remote - Switch Compatible - USB Rechargeable - Up to 23 hrs Runtime - Aero Bar Compatible Bracket SPECS - Solid Modes: High (60 Lumens): 1.5 hrs, Medium (40 Lumens): 2.5 hrs, Low (20 Lumens): 5.5 hrs - Flash Modes: *Daytime Flash (120 Lumens): 23 hrs, High Flash Slow (60 Lumens): 12 hrs, High Flash Fast (60Lumens): 7.5 hrs, Low Flash (25 Lumens): 18.5 hrs, Auto Safe Mode Extends Runtime an Additional 45mins - Weight: 40 Grams with Bracket - Battery: 500 mAh Lithium Polymer
NiteRider understand lights are an integral part of your daily commute. Using a light can mean the difference between being seen or not by automobile drivers. Many of the "entry level" commuter lights are nothing more than "be seen" lights. Your overall safety and visibility should not be limited by your budget, that's why NiteRider created the Mako Series. The Mako line offers three models and up to 250 lumens, not only allowing the cyclist to be seen, but allowing the cyclist to see as well. A favorite feature is the side "gills" that emits light, it not only looks cool, but makes the Makos more visible. The Mako line is easy on the wallet and easy to operate. - Side lights - Economical, high output light - Super bright flash setting ideal for daylight use - Easy operation battery operated (comes with 2 x AA) - 3 light settings – High, Low and Flash - Lumen Output: 200 - Run Time: 15:00 – 60:00hrs - Weight: 175g - Battery: Alkaline AA x 2 WARRANTY The Mako 200 is backed by NiteRider's lifetime warranty that covers any defects in material and workmanship, mechanical components (housings, covers, mounts and fasteners) and LEDs. SYSTEM INCLUDES - LED Light Head - Handlebar Mount - 2 AA Alkaline Batteries
Short days got you down? Missing that time spent shredding your local trails? Hit it hard, after-hours, with the Flux 800—a light that’ll see you maximizing your ride time without fear of being caught short in the dark. Mount it on your bike or on your helmet (helmet mount included), and you'll get direct light where you’re looking. Dominate the dark with dual Cree LEDs under dedicated wide and spot optics, which put lumens exactly where you need them. - Sculpted double-beam pattern puts light where you need it and maximizes every lumen. - Cree XPG2 and XPL LEDs - Quick-release bar mount works on 22.2, 25.4, and 31.8mm bars. - Mounting system centers light in front, above, or below the stem, with a long reach to work around most computer mounts and shifter/brake cables. - Extra bright side lights give you 180-degree visibility to other cyclists and motorists. - USB rechargeable 2600mAh Li-ion internal battery. - 300 to 800 lumens LED output. - 90% fast charge in 1.5 hours with full charge in 3 hours. - Four operating modes: Steady High Mode (800 lumens), Steady Low Spot Mode (300 lumens), Steady Low Wide Mode (300 lumens), Daytime Flash Mode (400 lumens). - Extra-long press-and-hold to lockout light for travelling.
- USB rechargeable 19 lumen safety light - 6 to 12 hour run tim per charge - 3 modes including 2 solid and 1 flashing mode - Multi-fit rubber strap mounting - Low battery indicator
• 2 bright Nichia LEDs • Uses 2 CR 2032 lithium batteries (included) • 100 hour run time • 3 modes: 2 flashing and 1 steady • Water-resistant silicone body
- 1.5 watt, 100-lumen USB-rechargeable headlight - 4 steady modes and 2 flash settings - Low-battery indicator
Sunlite's HL-K100 Headlight is a great light at a great price. It sports a super-bright Krypton bulb housed in a tough, water-resistant body so it's perfect for commuting year round. A no-tools-required quick-release handlebar mount is included, too.
Lezyne's Femto Drive Rear is a compact, bright, and beautifully made light. The lens is made of high-grade optical material and serves as an activation button that cycles through four flash and one solid mode. The CNC machined aluminum body makes the Femto Drive durable and weather resistant while the back plate can be unscrewed to replace the two CR2032 batteries. The multi-position silicone rubber strap secures the light to a wide range of seatpost and seatstay diameters.
- 20 lumen safety head light - Built in Li-Ion USB rechargable battery - 3 modes - 2 steady and 1 flashing setting - Multi fit rubber strap attachment - Low battery indicator
The Adventure line of NiteRider Headlamps receive a healthy bump-up in lumens this year. Now pumping 320 lumens output on High. Featuring a lightweight yet rugged build quality, the Adventure 320 Pro is a bright, versatile light that delivers reliability through NiteRider’s long history of outdoor digital electronics; so you can continue on through the darkest of nights. Equipped with our Pivot Stick-on Mount, this light easily mounts to most flat smooth surfaces. Meets FL 1 Standard IP67, protected against the effects of immersion in water to depth between 15 cm and 1 meter. - 4 Light Levels plus 1 Night Vision Mode - 4 Safety Flash Modes, including SOS - FL1 Standard IP67, water immersion ok between 15 cm and 1 meter - Removable mount - Adjustable light angle - Lightweight, weighing in at just 70 grams - Convenient USB rechargeable - Low battery indicator WARRANTY - The Adventure 320 Pro is backed by NiteRider’s lifetime warranty that covers any defects in mechanical components (housings, covers, mounts and fasteners) and LEDs. SYSTEM INCLUDES - LED Headlamp - Internal Li-Po Battery - Pivot Stick-on Mount - USB Charging Cable
The NiteRider Lumina 1000 Boost is the perfect light for mountain bikers, road riders, adventure riders and urban commuters. Featuring a tried and true handlebar mount (fits up to 35mm) that is sure to remain rock solid whether on the trail or pavement. Double clicking the power button activates Boost Mode, giving you the option to operate your light at 1000 lumens maximum light output! This self-contained light makes use of the IntelliCharge function, which charges the battery twice as fast as the normal charge rate when connected to a higher amp AC adapter. With the new NiteRider custom engineered collimator lens, the Lumina 1000 Boost projects a wide and even beam pattern of 1000 lumens! - All New Collimator Lens, produces a generous even widespread beam - Boost Mode, double click power button to unleash maximum LED output - 5 Light Levels plus 2 Daylight Flash Modes - CREE LED at 6000k - FL1 Standard IP64, dust and water-resistant - Secure on and off-road capable handlebar mount - Fits standard and oversize 35mm handlebars - Perfect for helmet mounting (Helmet Mount sold separately) - IntelliCharge – Reduce charge time in half! - Convenient USB rechargeable - Low battery indicator - Lock Mode, perfect for use during storage and transporting the light. Press and hold power button for 7 seconds to lock out operation of light. WARRANTY The Lumina 1000 Boost is backed by NiteRider's lifetime warranty that covers any defects in material and workmanship, mechanical components (housings, covers, mounts and fasteners) and LEDs. SYSTEM INCLUDES - LED Light Head - Internal Li-Ion Battery - Handlebar Mount fits up to 35mm - USB Charging Cable
- Compact, sleek design - Robust safety features including daytime and nighttime pulse modes - Side illumination ports allow cyclists to be seen when riding across traffic lanes - 6 modes including Daytime Pulse and Nightime Pulse - Fully USB rechargeable: no batteries to buy or replace - Memory function allows light to turn on at the last mode that was used - Power saving function automatically switches the light to the lowest lumen output when the battery gets to 10% power or less - Built-in battery indicator: red = lower than 25%, yellow = 50%-25%, green = fully charged - No tools bracket
Compact cycling safety light with two bright LEDs and a 200-lumen Daytime Flash mode. It features a super lightweight, yet durable co-molded construction that is IPX7 (waterproof) rated. NEW -- Up to 20 hours of runtime (eight hour increase) and up to 200 lumens (20 lumen increase) of output. And it features an integrated USB stick for convenient cable-free recharging. The KTV Drive Front offers five output modes. Specs - Max Lumens: 200 - Weight: 47.5g - Max Runtime: 20 hours - Recharge Time: 2:15
Compact, super-lightweight USB rechargeable LED cycling safety light. Its durable co-molded construction is minimal and has an IPX7 water-resistance rating. A versatile mounting strap quickly mounts to a variety of bar sizes. Five output modes offer up to 15 lumens and the custom Wide Angle Optics lens provides up to 270° of visibility. The Femto USB Front can run for up to 20 hours and is easily rechargeable with the included Micro USB cable. A secure, threaded composite matrix cover keeps the USB port clean and sealed. The Femto USB is perfect for commuters and recreational riders looking for a simple and inexpensive way to add visibility. Specs - Max Lumens: 15 - Weight: 22g - Max Runtime: 22 hours - Recharge Time: 2:30
Super bright and compact, Cateye's Omni 3 Front Safety Light uses CatEye's Omni Directional Technology for increased visibility. Three super-bright LEDs light up in three different modes so you can customize the pattern and extend the run time. Plus, CatEye's tool-free FlexTight mount makes installation easy.
- Simplistic safety light designed to be seen - Easy to install silicone strap attachment is compatible with 22.2-31.8mm bars - 3 modes including 1 steady and 2 flashing modes - Powered by 2 CR2032 batteries - Lumens: 12
Compact, durable cycling light with a machined aluminum body. It features built in cooling fins and cutouts for side visibility. Its single LED design provides up to an impressive 500 lumens of output and eight output modes—including a Daytime Flash mode. Runtime has increased by 2.5 hours for up to 20 hours. Charging is simple with an integrated cable-free USB stick. It securely straps to a variety of handlebar shapes and sizes. Specs - Max Lumens: 500 - Weight: 84g - Max Runtime: 20 hours - Recharge Time: 2:30 hours
- 20 Super Bright Cob LEDS - 4 Modes: High (1.5Hrs), Mid (4.5Hrs), Flash (5Hrs), Patrol (5Hrs) - Li-Ion Rechargeable Battery With Easy Magnetic USB Charger (1.5 Hrs Charge Time) - 40 Lumens - Waterproof - Optional Integrated Mount Designs For Giant Headsets, Overdrive1/Overdrive2 And Seatpost
Boasting 4200 lumens and 6 CREE LEDs at 6000k; the Pro 4200 Enduro offers 4 brightness settings and a daylight flash mode that are factory-tuned to optimize riding in any condition. And, a long-lasting 8-cell battery that doubles as a USB portable charger makes this lighting system perfect for long night rides, high speed MTB descents, or backcountry touring. - Ultra bright 4200 lumen output - 8 Cell Li-Ion battery, doubles as a USB portable charger - Remote switch for ease of operation - The preferred light for serious MTB riders - Highly durable light housing with Dupont Fiberglass reinforced nylon - Perfect for handlebar mounting - FL 1 Standard IP64, dust and water-resistant - 4 steady light modes and 1 daylight flash - Custom 3 cone dual-beam reflectors utilizing 6 CREE LEDs at 6000k - Convenient nylon storage pouch Warranty: - The Pro 4200 Enduro Remote is backed by NiteRider's lifetime warranty that covers any defects in material and workmanship, mechanical components (housings, covers, mounts and fasteners) and LEDs. System Includes: - LED Headlamp with Remote Switch - Li-Ion Battery/USB Portable Charger - Handlebar Mount - Fits up to 35mm - AC Adapter - Nylon Storage Pouch
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text:
M&S has revealed its Christmas ad campaign, featuring presenter Lisa Snowden and model Twiggy, ahead of its launch on TV tomorrow evening.
The ad also stars comedian Peter Kay, singer and presenter Dannii Minogue and former footballer Jamie Redknapp.
The 90-second ad sees Minogue and Snowden model 1920s style flapper dresses and Twiggy and Peter Kay dance around dressed in slick tuxedos. In the final scene the whole cast is surrounded by over 50 dancing Santas.
The campaign, which carries the strapline “Don’t put a foot wrong this Christmas”, launches on November 3 with the first airing of the clothing ad on ITV1 in the ad break during Emmerdale.

domain: artistic


text:
The new Nikon D600 camera goes on sale this week at a price of £1950 in most retailers. The camera fits in between the D3200 and the D800 in the Nikon range, with a 24 megapixel sensor. The Nikon D600 DSLR is fairly similar to the D800 — including a weather- and dust-resistant magnesium alloy build, …
Eilean Donan Castle is one of my favourite castles in Scotland , mainly because of the stunning location and ample photo opportunities . My picture of the castle at night is an HDR photo which is now available as a screensaver. The castle can be photographed from 3 sides
Melrose Abbey has been declared world class and one of Scotland’s best visitor attractions. Independent quality assurance inspectors from VisitScotland have awarded it the coveted five-star status after examining every aspect of the visitor experience. This means the three staffed Borders Abbeys cared for by Historic Scotland, and Smailholm Tower, are all now five-star attractions.
Stirling Castle is one of Scotland’s most impressive castles due to its imposing position and impressive architecture.
From the castle’s ramparts, visitors can take in views of the Forth Valley and Ben Lomond , as well as two of Scotland’s most important battle sites – Stirling Bridge (1297) and Bannockburn

domain: hobby


E. Conference Papers
 "Set-Based Predictive Control for Collision Detection and Evasion", Proceedings of the IEEE 15th International Conference on Automation Science and Engineering (CASE), pp. 541-546, August, 2019.
 "Analyzing Action Games: A Hybrid Systems Approach", Proceedings of the Foundation of Digital Games Conference, no. 8, pp. 1-11, August, 2019.


Year of Chrysler Stratus
Chrysler Stratus photos, specs - Car Pictures & Images
The Dodge Stratus (and its twins, the Chrysler Cirrus and Plymouth Breeze; collectively known as the "Cloud Cars") was a mid-size 4-door sedan introduced in 1995. It was based on the Chrysler JA platform Cab forward (car). The Stratus, Breeze, and Cirrus were all on Car and Driver magazine's Ten Best list for 1996 and 1997. It received critical acclaim at launch, but ratings fell over time. Production ended at the Sterling Heights Assembly Plant in early 2006 which had built 1,308,123 Stratus and Sebrings since 2000.The Dodge Avenger replaced the Stratus nameplate in early 2007 for the 2008 model year.
Used Chrysler Stratus
The Dodge Stratus, the middle entry of the JA platform (with the Cirrus being the higher-end model and the Breeze being the lower-end model), was introduced in 1995 with two models: the base (later renamed SE in 2000), which came standard with the 2.0L straight-4 and had the SOHC 2.4L as optional; and the ES, which came standard with the a 2.0L from 1995-1997, and had a DOHC 2.4L and a 2.5L V6 as optional. In 1998 the 2.4L was standard and the 2.5L V6 was optional on the ES, and from 1999-2000, the 2.5L V6 was the only engine on the ES model.
The Stratus directly replaced the high-volume Dodge Spirit to favorable reviews, but lower sales. It was often compared to other small mid-sizes such as the Chevrolet Malibu, and judged roomier than the Ford Contour by many magazines such as Consumer Reports. While the extended Ks had previously been Chrysler's main midsize offerings, the larger LH and LX platforms, conceived as replacements for the Dodge Dynasty and Dodge Monaco, would more directly compete with the Ford Taurus, the upsized Honda Accord and Chevrolet Lumina.
The cars had many parts that were interchangeable between each model. The exteriors of these three cars were very similar, with the front fascia, rear bumper, taillights, and wheels being the main differences. The interiors had little variation between the three models, being almost identical, save for the name on the steering wheel, and a few available options.
All three variants of the platform were available with most of the same standard features and available options, such as the following: a four-speed automatic transmission and an optional semi-automatic dubbed "Autostick" (not available on the Plymouth Breeze), anti-lock brakes, four wheel independent double wishbone suspension, tilt steering wheel, cruise control, power windows, power door locks, power driver's seat, leather seats, power antenna, a six CD changer, sunroof, remote keyless entry, anti-theft system, etc. A five-speed manual was available with the 2.0 L engine.
» Read More About Chrysler Stratus


text:
South African enforcer seeks maximum fines for K-Line
The Competition Commission of South Africa yesterday referred Japanese transport company Kawasaki Kisen Kaisha to the Competition Tribunal, asking the specialist court to fine the company 10% of its turnover for alleged price fixing, market division and bid rigging affecting the transportation of Toyota vehicles to Europe.
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domain: geography


Category: Sports Written by Roz Edward, National Content Director
(Reuters) - The Detroit Tigers beat the Boston Red Sox 1-0, nearly posting a rare postseason no-hitter in capturing the opening game of the best-of-seven American League Championship Series on Saturday.
Starter Anibal Sanchez and relievers Al Alburquerque, Jose Veras, Drew Smyly and Joaquin Benoit combined to keep the Red Sox without a hit until Daniel Nava dumped a single to center off Benoit with one out in the bottom of the ninth.
Pinch-runner Quintin Berry stole second base after Stephen Drew had flied out to right field but rookie Xander Bogaerts hit a towering pop-out to shortstop Jose Iglesias to end it.
The five Detroit pitchers bamboozled Boston batters in registering a total of 17 strikeouts at Fenway Park.
"It's unbelievable today with the pitchers," said Jhonny Peralta, the hitting star for Detroit.
Peralta, who rejoined the Tigers for the playoffs after serving a 50-game doping suspension, went 3-for-4 and drove in the game's only run in the sixth inning with a soft single to center off Boston starter Jon Lester that scored Miguel Cabrera.
Sanchez, the AL earned run leader at 2.57, set the tone from the start striking out four Red Sox hitters in the first inning, a feat enabled when a third strike got past catcher Alex Avila for a wild pitch that allowed Shane Victorino to reach first.
The Venezuelan stymied the Red Sox with a tantalizing assortment of pitches, all of which he moved around the strike zone at varying speeds.
The worst jam he faced was of his own doing, as he walked three batters in Boston's half of the sixth before striking out Drew to escape damage.
Sanchez struck out 12 and walked six and left the game after six innings and 116 pitches, only 66 of which were strikes.
"He gave us what we needed," said Tigers manager Jim Leyland, who had left-handed relievers warming up and looked close to removing him. "He made a great pitch to Drew to get out of that inning. We stuck with him and he came through."
The procession of relievers held Boston at bay, though Leyland could not relax as Detroit failed to cash in on their baserunners, stranding 12 in the game.
"A one-run lead and you almost feel like you're behind in this ballpark," the Detroit manager said with a nod to the short distance to the tall, left-field wall known as the Green Monster.
"I mean a walk and a home run over the Monster... you never feel comfortable."
Many Boston players complained about strike calls from the home plate umpire but Red Sox manager John Farrell said that was not a factor.
"I can't say that there was an issue with the umpiring because I would be taking away from the talent that this pitching staff has and they had good stuff," said Farrell, a former major league pitcher and pitching coach.
Benoit struck out Mike Napoli looking for the first out in the ninth before Nava singled to end the no-hit suspense.
Two more outs for Detroit would have registered the first combined no-hitter ever thrown in Major League Baseball's postseason.
The only previous postseason no-hitters were New York Yankee Don Larsen's perfect game in the 1956 World Series against the Brooklyn Dodgers, and Roy Halladay's no-hitter for the Philadelphia Phillies in the 2010 National League Division Series against Cincinnati.
Game Two of the series, which will produce the American League representative in the World Series, will be played on Sunday in Boston with Detroit's Max Scherzer (21-3) taking the mound against Clay Buchholz (12-1).
(Reporting by Larry Fine in New York; Editing by John O'Brien)
Last Updated on Sunday, 13 October 2013 18:26
Category: Sports Written by Fox 2 News
One win from reaching the AL championship series for the first time in seven years, the Oakland Athletics face a pitcher they knocked around just over a month ago.
The A's look to build on their latest showing and again frustrate Doug Fister as they try to close out the Tigers in Game 4 at Comerica Park on Tuesday.
Despite splitting the two AL division series games in Oakland, the A's looked a bit shaky having totaled three runs and three extra-base hits. Things didn't look promising Monday with a matchup against Anibal Sanchez, the AL's ERA leader at 2.57, but Oakland took him deep three times on its way to a 6-3 victory.
Last Updated on Tuesday, 08 October 2013 09:30
Category: Sports Written by Eric Guster/ NewsOne Staff
The National Collegiate Athletic Association (NCAA) and universities are the perfect plantations. They have slaves who work for them tirelessly for no money. For free. Not a dime. Not only do the slaves work for the NCAA and the universities, but the slaves earn the NCAA and said universities millions of dollars in various forms of revenue. They have money rolling in 24 hours a day, 7 days a week! In business, we call that a multiplication of your efforts: making money while you sleep.
It is the perfect situation for the plantation owners and handlers, but does nothing to help the slaves.
The plantation owners get to make money off the labor of the slaves in various forms, including selling shirts and other officially licensed gear with the names, faces, and identification numbers of the slaves while prohibiting the slaves to earn any money at all.
All plantation owners have to do is give the slaves a room to sleep, food to eat, and classes, while the owners earn millions. I guess the classes are a step up from the old plantations, but it is still a pretty good deal for the owners.
Let me break it down for you: The plantation owners are the universities and the NCAA. All of them have a collective agreement to share the slaves and the revenue from them. The slaves, of course, are the football players. The minders or the handlers are the coaches. The merchants who go to the market to trade the slaves are the agents.
A major change in this new-era of plantation is that now Whites, Blacks, Hispanics, and other races are included. They all are subjected to similar treatment, with, again, no payment for their services. Not only are they cheated because of the amount of income they make for the plantations (universities and NCAA), but they are also subjected to the long-term effects of injuries sustained while playing sports.
There are no funds set aside for the players who suffer concussions, broken limbs, memory loss, and other ailments.
All a player gets is a "thank you for your football playing days" and possibly a championship ring or two.
That is it.
However, universities do provide scholarships to other students and provide them with a stipend. You know, spending money. For example, the University of Alabama gives merit scholarships with a stipend of $3,500 per year, including tuition and room and board. In other words, you get extra spending money just for being smart.
Last time I checked, the merit scholars did not make millions for the universities, did not have their names and identification numbers for sale, and people did not pay lots of money to see them perform — yet they get paid for school.
It's simply not fair.
One of the major issues with the NCAA rules is that players cannot be paid a stipend, cannot make money off of autographs or appearances, and the players cannot profit from their own likeness; slavery, of course, works that way.
The players risk their lives and health for the sport but cannot get enough money to get them a cheeseburger or buy a pair of shoes. Due to their grueling football practice schedules, these players do not have the opportunity or time to procure a part-time job. Many are from low-income families who cannot afford to send them spending money for the weekends.
That is a travesty and a shame.
It is time for the rules to be changed to protect the players.
At the end of their four-year tenure on the plantation, the slaves are taken to the NFL scouting combine to be measured, weighed, sized up, and tested for agility. This is where the merchants come in to play. If you know your history, the market was the place where all slaves were traded. They were put on display like animals to be looked over to see which specimen was best.
Sounds familiar, huh?
If that is not modern-day slavery, tell me what is.
Eric L. Welch Guster is founder and managing attorney of Guster Law Firm in Birmingham, Ala., handling criminal and civil matters, catastrophic injuries, criminal defense, and civil rights litigation. Mr. Guster has become a go-to lawyer for the New York Times, NewsOne, NBC, CBS, ABC, FOX, Black America Web, and various radio programs about various court issues and high-profile cases.
Follow Guster on Twitter @ericguster.
Last Updated on Friday, 13 September 2013 15:17
Category: Sports Written by Nick Hopson
Through two games, Reggie Bush has already been injured three times. He has hurt his finger, his groin and his knee. Although none have been season threatening, he is still missing a fair amount of time. For Sunday’s game against the Redskins, Bush is said to have a fifty-fifty chance at playing.
Considering that Bush is a big part of the Lions offense, it is necessary that they have a suitable backup. The Lions have that this year in Joique Bell. He is a hard runner with pass catching ability that can help the Lions on a regular basis.
Bell is a Michigan native who was born in Benton Harbor in 1986. He attended Wayne State University for football. He won the Harlon Hill Trophy his senior year rushing for 2,084 yards and 29 touchdowns. The Harlon Hill Trophy is the award that is given to the most valuable player in NCAA Division II. It is basically the Heisman trophy at the Division II level.
Following his award winning season, he went undrafted in 2010. After going undrafted he bounced around on several practice squads. Originally he was signed by the Buffalo Bills to their practice squad but was signed off of it by the Eagles.
In the same year, he was cut by the Eagles and claimed by the Colts. He played in 5 games for the Colts but registered no stats. The Colts eventually cut him and he was resigned by the Eagles. He appeared in three games before being cut by them yet again.
In 2011 he signed with New Orleans’ practice squad. The Lions signed him off the Saints’ practice squad when they were dealing with running back injuries. He made his debut for the Lions September 9th, 2012. In his first season for the Lions, he racked up 414 rushing yards and three touchdowns on 82 carries. He also had 52 catches for 485 in his first season with the Lions.
His production led the Lions to resign him before the 2013 season. He is now an important part of the Lions offense. His versatility and his determination have created a spot for him on this team. He is a more than capable replacement for Reggie Bush.
Bell will most likely get a lot of use Sunday even if Bush ends up playing. The Lions play the 0-2 Redskins on Sunday at 1.
Last Updated on Friday, 20 September 2013 19:05
Category: Sports Written by Ruth Manuel-Logan/newsone
Legendary boxing champ Oscar De La Hoya (pictured) voluntarily checked himself in to a rehab facility Monday night, just two years after completing a program for cocaine and alcohol addiction, according to USA Today. While the details as to which substance the former boxer is battling are yet to be released, many speculate that the same demons which have haunted him in previous times have once again resurfaced.
The 10-time world-title winner announced that he will not be present at the highly-publicized upcoming "battle of the year" between undefeated welterweight titleholders Floyd Mayweather, Jr. and Saul "Canelo" Alvarez on Saturday night because of his substance abuse problems. De La Hoya, who is president of the mega-successful boxing promotion company, Golden Boy, will be producing the fight and has been a mentor to AlvarezDe La Hoya, who retired shortly after boxing superstar Manny Pacquiao stopped him in the eighth round in 2008, said he had a chat with Alvarez and he understood that his need for entering the treatment facility to seek help for his addiction took precedence over the much-anticipated boxing match:
"I explained this to Canelo, and he understood that my health and long-term recovery from my disease must come first. Thank you for your understanding. I ask for your support and privacy during this difficult time for me and my family. I'm sure he's going to win his battle, and I'm going to win my battle," De La Hoya said in a press statement that was released on Tuesday.
Two years ago, De La Hoya was MIA due to another drug and alcohol rehab stint for another historical boxing match between boxing great Bernard Hopkins and opponent Jean Pascal in a rematch that took place in Montreal. The Hopkins/Pascal fight made boxing history because Hopkins, a.k.a. "The Executioner" who is considered to be one of the greatest middleweight champions of all time, became the oldest fighter to ever win a world championship. Hopkins was 46-years-old when he fought Pascal; De La Hoya's Golden Boy produced the battle.
Mayweather, who reportedly does not indulge in vices such as drinking alcohol or smoking and who defeated De La Hoya in 2007, has been quoted in the past as saying, "I wouldn't even show up to the fights if I were him [De La Hoya]," according to USA Today.
Still, Mayweather appears to have no ill will toward De La Hoya, telling USA Today, "I wish him nothing but the best. Hopefully he will pull through like a true champion."
Last Updated on Wednesday, 11 September 2013 11:37
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Viral video: A350 takes off right before Airbus A380 lands on the same runway
A viral video shows a large, wide-body aircraft Airbus A350 taking off just in time for the world’s largest plane, Airbus A380, to land. The breathtaking clip, filmed during a 2014 airshow in Farnborough, England, captures consecutive take off and landing of the aircrafts on the same runway strip. While it looks like the superbeast A380 is closely following the A350, it’s a safe enough distance away to stay clear of the wake turbulence from the leading aeroplane.The now-viral video, shared by an aviation account on Twitter called Airplane Pictures, has racked up 3.7 million views.
© 2022 Bennett, Coleman & Company Limited


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