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- Mets Make Waiver Claim To Acquire Reliever
- Denard Span To Undergo Season-Ending Hip Surgery
- Mariners Fire GM Jack Zduriencik
- MLB Wins Collusion Case Versus Barry Bonds
- Cubs Acquire Fernando Rodney, Designate Brian Schlitter
- Chris Perez Retires
- Hanley Ramirez To Play First Base For Red Sox In 2016
- Austin Jackson Clears Waivers, Generating Interest
- Sabathia Possibly Done For Season; Yankees Re-Sign Capuano
- Astros, Dallas Keuchel Have Discussed Long-Term Deal
Trade Rumors Apps
Weekly email list
- AL Notes: Blue Jays, Mariners, Gordon
- Padres Pull Kimbrel Back From Waivers
- Mets Make Waiver Claim To Acquire Reliever
- Blue Jays Designate Ty Kelly For Assignment
- Quick Hits: Francona, Price, Flores
- Front Office Notes: Zduriencik, Dipoto, Anthopoulos
- Week In Review: 8/22/15 – 8/28/15
- AL East Notes: Buchholz, Red Sox Front Office, Hanley, Shapiro, Tolleson
- Front Office Notes: Brewers, Reds, Levine, Mariners
- Blue Jays Claim Danny Dorn
- Heyman’s Latest: Castro, Shapiro, Davis, Anderson, Brewers, Phils
- Minor MLB Transactions: 8/28/15
- Rangers Designate Chris Rearick For Assignment
- Rockies Designate Ken Roberts For Assignment
- Cardinals Hire Randy Flores As Director Of Amateur Scouting
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Aaron Hicks Rumors
Promotions are always interesting to keep an eye on this time of year, as teams look to balance future control and cost with developmental prerogatives and the needs of the MLB roster. One of the most-watched players, shortstop Carlos Correa of the Astros, will make his debut today at Triple-A after destroying the Double-A level at just twenty years of age. The next stop could be Houston, where the big league club playing well but dealing with a significant injury to Jed Lowrie. Meanwhile, the Twins have decided the time is ripe to give another shot at former top prospect Aaron Hicks, still just 25, who has struggled in his time in the majors but forced his way back with a .336/.415/.561 run through the highest level of the minors this year.
Here’s more from the American League:
- The Angels, who have fielded a somewhat surprisingly unproductive lineup thus far, look in need of a bat, as Jeff Fletcher of the Orange County Register writes. While GM Jerry Dipoto says that he expects at least some of the team’s group of established hitters to return to their usual contributions on offense, Fletcher says that the front office is ready and willing to pursue an acquisition over the summer. Given the team’s struggles against right-handed pitching, Fletcher opines that Brewers first baseman Adam Lind would make for a particularly sensible trade target. He ticks through a few other plausible options as the market begins to take shape.
- Yankees starter Masahiro Tanaka is set to throw his first bullpen today since suffering a forearm strain, MLB.com’s Bryan Hoch tweeted yesterday. At this point, it would seem to rate as a pleasant surprise if Tanaka is able to contribute more quality innings this year, though the club seems determined to give him every opportunity to return before pursuing more drastic options.
- Indeed, as Joel Sherman of the New York Post writes, the Yankees rotation has plenty of issues but still rates as the most complete outfit in the division. GM Brian Cashman continues to say that he believes Tanaka can stave off a Tommy John procedure. And as Sherman rightly notes, Chris Capuano and Ivan Nova both appear on track to deliver useful arms in the relatively near future. If the club stays in position and has a need, of course, it should have no difficulty finding ways to add quality innings via trade over the summer.
- The Red Sox staff, meanwhile, has been a source of near-constant hand-wringing and speculation for months. There are reasons to believe in improvement from the peripherals, as MLB.com’s Anthony Castrovince explains, though as he notes the biggest reason for hope may lie in the club’s evident ability (and demonstrated willingness) to swing deals to add additional arms.
- Red Sox GM Ben Cherington continues to emphasize the organization’s commitment to delivering better results from its internal pitching options, as Scott Lauber of the Boston Herald reports. “We knew we needed good pitching coming into the year to win games, and we still know that,” says Cherington. “I believe we’ll pitch better, and I believe we have a lot of the solutions here already.” Cherington emphasized that he wants to see how things proceed with a new pitching coach (and new backstop duo) now in place. Regardless, as he notes, it would be hard to make a move now. “Not a lot of teams are in that (trade) mode,” said the Red Sox GM, “but there wouldn’t normally be this time of year anyway. We’re not really there yet. There’s not a lot of team-altering moves being discussed this early. Probably need a little bit of time on that.” In Lauber’s estimation, Cherington’s protestations notwithstanding, Boston must and will strike one or more trades and/or promote well-regarded lefty Eduardo Rodriguez for an infusion of talent.
- One possible trade target for the Red Sox (and, of course, other teams) is Athletics lefty Scott Kazmir, Nick Cafardo of the Boston Globe opines. Indeed, Kazmir’s strong recent track record and meager remaining commitment, to say nothing of the free-wheeling nature of Oakland GM Billy Beane, frame him as a popular source of trade speculation over the next few months. If the team decides to market him, which seems more and more plausible with each passing day for the 12-22 A’s, it will be fascinating to see what the 31-year-old returns in a trade.
The Twins have optioned Aaron Hicks to Triple-A Rochester, Phil Miller of the Star Tribune writes. Heading into Spring Training, Hicks had seemed to be the likely choice for the Twins’ starting center field job. He has struggled this March, however, putting up a .206/.300/.324 line that’s very consistent with his career .201/.293/.313 performance. The demotion is another setback for the former first-round pick, who is still struggling to establish himself at age 25. It appears the team will go with Jordan Schafer and Shane Robinson in center field. Here’s more from the Central divisions.
- New MLB commissioner Rob Manfred praised the Pirates while visiting with the Bucs and Twins Friday, Rob Biertempfel of the Pittsburgh Tribune-Review writes. “I think the Pirates have tremendously benefited by (owner) Bob Nutting’s presence and leadership,” Manfred said. “For those of you who know the history, you’re not going to be surprised to hear me say I am a huge Frank Coonelly fan. I think he’s done a fantastic job as president of the Pirates, including his selection of (general manager) Neal (Huntington).” Coonelly worked in the commissioner’s office before becoming the Pirates’ president. Manfred added that his controversial comments about banning defensive shifts were only an idea, and that the league isn’t likely to make changes in that area, particularly given the feedback he’s gotten about it.
- Ryan Madson‘s opt-out with the Royals is May 1, Andy McCullough of the Kansas City Star tweets. The 34-year-old Madson, who’s had a mess of injuries and hasn’t pitched in the big leagues since 2011, is attempting a comeback with Kansas City. He’s gotten decent results so far, striking out four batters and walking none in seven spring innings. The Royals have another month to evaluate him, however, which makes sense — one imagines he’ll still need time to prepare to pitch in meaningful games, given all the time off he’s had.
Phil Hughes was two years away from free agency but both he and the Twins realized that they wanted to hammer out something for the long term. In December, Hughes agreed to a three-year extension that will pay him $42MM but also allow him to cash in again at the age of 32.
For both sides, the deal appeared to be a win-win. The Twins locked up Hughes following his best season to date and Hughes will get to hit the open market roughly at the same age as James Shields when he inked a four-year, $75MM deal with the Padres in February. In a pre-game scrum with the Twins’ beat writers on Monday, I asked GM Terry Ryan if the club ever pushed for a longer deal with the right-hander.
“I think that’s kind of where our comfort level was, he was signed for two and we tacked on more…In essence, I think that’s where we felt pretty comfortable in terms of his age and what he accomplished in his life and all that stuff,” Ryan said. “We were comfortable with it and so was he. At the end of the deal he’ll be  and that’s getting to an age when you start to have a bit of…concern at that point but then again, that’s how old Ervin Santana is and we signed him to a four-year deal. He’s a young guy, he’s been around for a long time. That’s what happens when you sign out of high school and move into the majors quickly.”
Meanwhile, this spring, Eduardo Escobar has presented the Twins with one of those good problems to have. Escobar’s production at the plate has made some wonder if he could force shortstop Danny Santana back to the outfield, unseating Aaron Hicks. I asked Ryan about that possibility and he seemed to downplay the chances of that happening.
“No, we’re still going with that path, there’s still competition but Santana is certainly playing well at short. Paul [Molitor] said he’d like him to be there if he plays well and to this point he has. Escobar has had a fine spring and I’ve stated this many times. It’s going to be tough to get him out of that position because he played well last year and he played well this spring,” Ryan said. “I don’t think I’m prepared right now to tell you who is going to play center and I’m not prepared to tell you who is going to play short, but Hicks is certainly in the mix and Santana is in the mix.”
Later, Escobar saw some time in the outfield in an effort to get him comfortable with playing multiple positions off the bench, as Ryan explained to MLB.com’s Rhett Bollinger and other reporters after the game.
Any Tigers fans that were holding out hope for a Jose Iglesias return in late 2014 will have to wait until next year, as GM Dave Dombrowski told Tony Paul of the Detroit News today that the team doesn’t expect the defensive wizard back at any point in 2014. Previous reports had indicated that Iglesias was likely to miss “most” of 2014 with stress fractures in his shins, though most were already operating under the assumption that his season was indeed lost. Detroit has a definite need at short, as the players that have manned the position to this point have combined for an MLB-worst .187/.239/.235 batting line while adding negative defensive contributions according to both Ultimate Zone Rating and Defensive Runs Saved.
Some more links pertaining to the Tigers and their division…
- James Schmel of MLive.com fielded plenty of interesting questions in his latest Twitter mailbag, including some on Victor Martinez‘s future with the Tigers and the team’s deadline approach. He feels V-Mart will receive a qualifying offer, but the Tigers will be hesitant about a deal of three of more years for their aging DH. He adds that the Tigers likely feel they’re set in the outfield with Andy Dirks on the mend, but it’s not hard to envision them targeting some rotation depth next month.
- The Twins are continuing to look for a stopgap option in center field so they can option Aaron Hicks to the minors, reports La Velle E. Neal III of the Minneapolis Star Tribune. One potential option, Sam Fuld, is currently nearing a rehab assignment after sustaining a concussion last month, Neal writes. Hicks recently gave up switch-hitting in favor of what has long been a superior right-handed stroke, but learning to gauge breaking balls from right-handed pitchers as a right-handed hitter at the Major League level is a tall task. Hicks’ .722 OPS as a right-handed hitter in his career dwarfs his .549 mark from the left side.
- Justin Masterson spoke with WEEI.com’s Rob Bradford on the Indians‘ recent trip to Boston about his contract situation. Masterson said he’s following his former teammate Jon Lester‘s lead as the pair approaches free agency, not letting it distract him after failing to reach an extension agreement in Spring Training. “I’m the exact same way. One way or another, something is going to happen. It doesn’t matter if we’re talking about it or not.” He added that while he hasn’t tracked the success of other impending free agents, he has kept an eye on Lester’s numbers, but only because the two are friends.
The Mets have announced that they will promote former star outfielder Bobby Abreu from Triple-A Las Vegas tomorrow. Abreu is 40 and hasn't played in the big leagues since 2012, which he spent with the Angels and Dodgers. But he made a good impression in Vegas, hitting .412/.500/.529 in 40 plate appearances there, and the Mets have space for a left-handed bench player after trading Ike Davis to the Pirates. As Newsday's Marc Carig tweets, that means the Mets' active roster will include Abreu, Bartolo Colon, Kyle Farnsworth, Daisuke Matsuzaka and Jose Valverde. Here are more notes from around baseball.
- Zack Thornton, the reliever the Mets acquired (along with a PTBNL) in the Davis trade, made his debut in the Mets organization on Sunday, pitching two innings for Las Vegas against El Paso. Thornton allowed a solo homer to Kyle Blanks, but allowed no other runs while striking out one in two innings. The player to be named is reportedly the "key piece" in the deal.
- The Twins' decision to claim Sam Fuld could impact Aaron Hicks, Mike Berardino of the St. Paul Pioneer Press reports. Twins assistant GM Rob Antony says the Twins are considering having Hicks get fewer at-bats against righties. If they do, Fuld, a lefty, is a likely candidate to take Hicks' playing time. Hicks is hitting just .179/.299/.214 in 67 plate appearances so far this season.
For the fourth straight year, Twins assistant general manager Rob Antony sat down with Jesse Lund of SB Nation's Twinkie Town to discuss the state of affairs with his team. Antony and Lund discussed the Twins' offseason at length, ranging from the trades of Denard Span and Ben Revere to the Twins' pursuit of starting pitching. Here's a look at some of the highlights, but bear in mind that entire piece is well worth your time…
- The Twins never intended to trade both Revere and Span, but the Phillies' offer of Trevor May and Vance Worley was too strong not to pull the trigger. Antony identifies May as someone who could get a September call-up in 2013 if he enjoys a strong season.
- The Twins had conversations with both Scott Baker and Francisco Liriano, but were unable to agree to terms with either one. In particular, the Twins sought a club option for Baker, who wanted strictly a one-year deal. Antony said they didn't want 2013 to "be a donation" to Baker in the event that he wasn't healthy and effective for most of the season. That decision looks wise, with Baker on the 60-day disabled list for the Cubs.
- Mike Pelfrey identified the Twins as a team he wanted to pitch for and was aggressive in working out a deal, according to Antony. The Twins did quite a bit of homework on Pelfrey's recovery from Tommy John surgery in order to ascertain that the right-hander would indeed be ready for Opening Day, as he promised.
- The Twins made several "competitive offers" to free agent starting pitchers, in some cases making better offers than the ones those pitchers ultimately took. The Twins had conversations with nearly every free agent starting pitcher and spoke with around 15 agents for pitchers at the Winter Meetings in December.
- Following the Span trade, most teams didn't believe that the team would also trade Revere. Antony says four teams were in the mix for Revere, but the Phillies were the most aggressive and ultimately landed him with the aforementioned offer.
- The Twins were willing to do a one-for-one swap of Span and Alex Meyer because they believe Meyer is a legitimate front-of-the-rotation candidate who can be a "dominant" strikeout pitcher.
- The decision to bring Aaron Hicks north as the team's Opening Day center fielder was a result of Hicks' strong play in Spring Training and his poise off the field. The Twins' front office was never overly concerned with delaying Hicks' free agency by a season: "If he's that good of a player we're going to do what we can to sign him long term and none of that's going to matter."
- Antony, GM Terry Ryan and the rest of the front office prefer to gradually expose their top prospects to the Major Leagues so as not to field a team of all rookies. Additionally, that line of thinking prevents mass arbitration and free agency issues: "If you can bring a couple guys, a couple rookies in each year, it helps infuse that and it helps to spread it out so that not everybody becomes arbitration eligible at the same time or free agents at the same time, all that stuff."
- The Twins "admire" the Royals' bullpen of power arms and would like to build a similar bullpen. The team prioritized power arms in the 2012 Draft, selecting a number of hard-throwing college relievers.
- Antony offered a definitive "No," when asked if the team had interest in Aaron Harang prior to his trade to the Mariners. The Twins feel they have a number of similar arms in the organization already.
- There's been no contact between the Twins and Jim Thome for "a couple of months," and the two were never on the same page. Minnesota had interest in Thome, but they were far apart in discussions.
- "It would be great if he could be a Twin for life," Antony said of Justin Morneau. "He's a guy who's meant a lot for this organization and we'd love it if he were to play his entire career here, but you just don't know how things are going to work out in the end."
- Antony feels that too much has been made of the decision not to extend Ron Gardenhire prior to this season. Many have speculated that Gardenhire is on the hot seat following a pair of 90-loss seasons, but Antony said it was intended to be an organization-wide message that they're looking to get better from top to bottom. He adds that he hopes Gardenhire is the Twins' manager for years to come, and that in three years people are surprised there was even a debate.
Jose Fernandez of the Marlins, Aaron Hicks of the Twins, and Jackie Bradley, Jr. of the Red Sox are all on their teams' Opening Day rosters, even though that might make them free agents a year earlier, and Ken Rosenthal of FOX Sports is rooting for all three of them. Rosenthal says he's tired of watching talented players languish in the minors at the start of each season as their teams attempt to delay their service-time clocks. The best players should be on the field, Rosenthal argues. "The game is so flush with cash, teams are awarding hundred-million dollar extensions like Halloween candy," he says. "I’ll grant that certain low-revenue clubs need to watch their money more carefully than others. The rest of ‘em, no way."
- "The system" keeps the Rays on a winning path, Marc Topkin of the Tampa Bay Times writes. "One of the things I'm most proud of is that we've been able to remain committed to our plan," says executive vice president Andrew Friedman. "It takes a tremendous amount of discipline because there are times when it is very tempting to deviate from that plan, but I feel very confident that had we done that in '08 or '09 we wouldn't be sitting where we are today." Topkin notes that the Rays haven't been successful in every area — they haven't done well in the draft recently, and they haven't had much success with catchers and designated hitters. But a key area at which they have been successful is in developing their own starting pitching. By developing their own pitching, they're able to not only avoid expensive free-agent commitments, but to trade from their own stockpile, as they did when they sent James Shields and Wade Davis to the Royals for Wil Myers and prospects.
- Bud Selig isn't concerned about the Cubs' debt, Gordon Wittenmyer of the Chicago Sun Times reports. The Ricketts family purchased the Cubs for $845MM in 2009, and the team still has substantial debt related to that purpose. "The Ricketts family worked closely with our office to develop certain financial structures designed to [ensure] the stability of the franchise at these debt levels," a spokesman for Selig says.
The Twins announced yesterday that they will hand the reins in center field over to top prospect Aaron Hicks. The 2008 first-rounder ranked 72nd on Baseball America's Top 100 list and 98th on MLB.com's Top 100. Here's some more on the Twinkies as we draw closer to the end of Spring Training…
- General manager Terry Ryan told MLB.com's Rhett Bollinger that Hicks won the Opening Day job because he doesn't believe in holding players back for service time reasons: "'Can you imagine if we sent somebody out who did what the kid did?' Ryan said. 'And I had to look at [Josh] Willingham, [Justin] Morneau, [Glen] Perkins, [Joe] Mauer and those guys who are trying to win, and I'm going to stop that guy? I just don't believe in that.'"
- Other teams are interested in catcher Drew Butera, who the Twins optioned to Triple-A yesterday, according to Ken Rosenthal of FOX Sports (on Twitter). However the Twins prefer to keep Butera, who they signed to a $700K contract in order to avoid arbitration this winter. The 29-year-old is just a .183/.232/.265 career hitter but is regarded as a terrific defensive catcher.
- The Twins contacted Chris Young this offseason and had interest in him at one point according to Andy Martino of the New York Daily News, but an official tells Adam Kilgore of the Washington Post that the team no longer considers him a fit (Twitter link). Young is set to opt out of his contract with the Nationals.
- The Twins were approached by representatives for both Yuniesky Betancourt and Freddy Garcia, according to Darren Wolfson of 1500 ESPN, but the team passed on both players (Twitter links).
- Outfielder Wilkin Ramirez, who signed a minor league deal with the Twins, has all but guaranteed himself a spot on the Opening Day roster, tweets MLB.com's Rhett Bollinger. A corresponding 40-man roster move will need to be made in the coming days.
Here's a look at tonight's news out of the AL Central..
- Tigers right-hander Bruce Rondon struck out two and did not issue a walk this afternoon in what was his best outing of the Grapefruit League season so far. In fact, if the rookie had thrown this well in his previous outings, the Tigers would probably feel more confident about their closer situation, writes Chris Iott of MLive.com. The Tigers are said to be scouring the trade market in search of a proven ninth-inning option.
- When asked if whether starting the service time clock will play a role in whether prospect Aaron Hicks makes team, Twins General Manager Terry Ryan responded, "Not here," according to Rhett Bollinger of MLB.com (on Twitter). Recently, our own Ben Nicholson-Smith looked at service time considerations for Hicks and other top prospects across baseball.
- The pain of a 68-94 season was the Indians' motivating factor in going out and getting Michael Bourn, Nick Swisher, Mark Reynolds, and Brett Myers, CEO Paul Dolan told Terry Pluto of The Plain Dealer. "We didn't want to go through something like that again," he said. "In some ways, it was a shock we needed."
Here's the latest from Joel Sherman of The New York Post…
- The Mets are making progress, albeit slowly, in contract talks with David Wright and R.A. Dickey. The impression is that there is still a substantial gap in talks with Dickey, and they've been gauging his trade value during the GM Meetings. They are not doing the same with Wright, however.
- The Yankees would not do a two-year deal worth $20MM or so for Torii Hunter since they want to get under the luxury tax threshold next year. They are fixated on one-year contracts this offseason and could fill their right field hole with a low-cost platoon.
- "The Yankees are not on him," said a source about Justin Upton, in part because they're unsure if he's a good fit for New York (Twitter link). The Rangers and Rays are strongest early players for Upton, and Sherman gets the sense that the D'Backs want to act quickly (Twitter links).
- The Diamondbacks want high-end, MLB ready players in return for Upton and would love to get Jurickson Profar or (more likely) Elvis Andrus from the Rangers. They don't love Mike Olt, however (Twitter links). GM Kevin Towers likes Yankees prospect Mason Williams, but he is several years away from the show and unlikely to be enough to headline a trade package (all Twitter links).
- Next year's crop of free agent starting pitchers is weak, which could benefit Zack Greinke since teams won't be able to find a stopgap and reassess next year. Josh Johnson and Tim Lincecum highlight next winter's pitching crop, and both come with question marks.
- The Mariners, who have young pitching, are said to be talking to the Royals and Twins, who have young hitting. Seattle would love to pry Wil Myers, Aaron Hicks, and/or Ben Revere loose.
- Jason Bay didn't produce with the Mets, but he lived up to his billing as a hard worker and good teammate. Sherman expects the outfielder to take a low-salary, change of scenery deal (Twitter link).
- Mets officials think Scott Hairston will get a two-year deal worth between $8-10MM this winter.
Full Story | 25 Comments | Categories: Aaron Hicks | Arizona Diamondbacks | Ben Revere | David Wright | Elvis Andrus | Jurickson Profar | Justin Upton | Kansas City Royals | Mason Williams | Mike Olt | Minnesota Twins | New York Mets | New York Yankees | R.A. Dickey | Scott Hairston | Seattle Mariners | Tampa Bay Rays | Texas Rangers | Torii Hunter | Wil Myers | Zack Greinke

domain: sports


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CKDGEN Meta-Analysis Data
These files contain the summary meta-analysis data from the CKDGen consortium for the following 5 traits from the Kottgen et al. 2010 and Boger et al. 2011 publications:
(These are .csv zipped files)
Within each file, the data are presented as follows:
- rsID, allele1, allele2, freqA1, direction, pval
- Allele1=the coded allele
- Allele2=noncoded allele
- FreqA1 is the frequency of allele1 from the Hapmap CEU sample
- Direction refers to the direction of effect for allele1. Can be +/-/0.
- The p-value is the double GC corrected p-value.
The preferred citations are as follows:
- For eGFRcrea, eGFRcys, and CKD: Kottgen A, Pattaro C, Boger CA et al. New loci associated with kidney function and chronic kidney disease. Nat Genet 2010 May;42(5):376-84.
- For UACR and MA: Boger CA, Chen MH, Tin A et al. CUBN Is a Gene Locus for Albuminuria. J Am Soc Nephrol 2011 Mar;22(3):555-70.
Listing of Mendelian disorders with known renal phenotypes and meta-analysis results of associations between common variants in Mendelian renal dysfunction genes with estimated glomerular filtration rate and chronic kidney disease
This downloadable file has six tabs corresponding to the following table:
- Table 1: List of Mendelian disorders with primary renal developmental or glomerular related dysfunction
- Table 2: List of Mendelian disorders with primary renal tubular dysfunction
- Table 3: List of Mendelian disorders with secondary cause for renal injury
- Table 4: eGFR meta-analysis results for top associated SNP within each Mendelian kidney disease gene
- Table 5: CKD meta-analysis results for top eGFR associated SNP within each Mendelian kidney disease gene
- Table 6: Complete eGFR meta-analysis results of all SNPs in the 258 Mendelian kidney disease genes
Afshin Parsa, Christian Fuchsberger, Anna Köttgen, et al. Common Variants in Mendelian Kidney Disease Genes and Their Association with Renal Function and CKD. J Am Soc Nephrol, 2013 Sep 12. [Epub ahead of print] PubMed PMID: 24029420.
Details regarding the case numbers and samples can be found within these published documents. If you have any questions, please contact Dr. Caroline Fox at email@example.com.

domain: literature


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As FOMC decision re interest rate approaches next week, looking for selling pressure on gold to subside. TGB and other low priced gold miners should benefit from stable gold prices. Looking for a double in the next 6 mo.
After a terrible bear market where IPI got decimated by about 95% the fist signs of green shoots emerge. After consolidating for a year, IPI on track for a yearly high. If Ag stabilizes IPI has a strong potential for recover substantially over the coming year.
RSX has been in a relentless downtrend, but has now traded past a lower hi at 18. If OPEC meeting tomorrow is perceived as positive for $OIL, RSX should be on the next leg up with 1st target at 21-22, and then at 25-27. Best.

domain: finance


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Prepare to share, preserve and record your research data at the end of a project.
Research funders and publishers often require scholarly publications and their underlying data to be linked using persistent identifiers, which provide stable, longlasting references to digital content. The best known variety of persistent identifiers are Digital Object Identifiers (DOI). Depositing your data in DataShare will generate a DOI, as will creating a metadata record for it in PURE.
DataShare open access data repository
Everything you need to know to deposit and begin sharing your data publicly.
DataVault long-term retention
A service to archive golden copy research data.
Choosing a repository
What you need to consider when depositing your research data
Pure for datasets
Record your datasets and link them to your projects.

domain: library


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Could It Be ThyroidDisease? Signs and Symptomsby
There are signs and symptoms that can signal thyroiddisease. Some people get only one or two..., but can be find almost anywhere during research into thyroiddisease. If you find yourself with some of these symptoms, have your thyroid check...
Top 10 Signs That You May Have a Thyroid Problemby
, but the majority don't even know it yet. The thyroid, a butterfly-shaped gland located in the neck, is the master..., but here are some of the most common signs that you may have a thyroid condition:
To continue to read this article please click...
Celiac Disease and ThyroidDisease–Two of a Kindby
What is autoimmune thyroiddisease?
The Thyroid is a gland in the neck that controls most of the other hormones....
What are the signs and symptoms of ThyroidDisease?
The signs and symptoms associated with ThyroidDisease vary...
Signs & Symptoms of Graves' Diseaseby
Here is a list of some of the common signs and symptoms of Graves' Disease:
Blurred vision... flow
Low levels of thyroid stimulating hormone
Lump on front of neck
Are Brinkles a Sign of Heart Disease?by
The Framingham Heart Study*also found the thickness of a person’s neck provided as many clues...’ as they could be a sign of future heart problems. Brinkles – the term used to describe wrinkles of fat which appear...
Genetics Home Reference: Graves diseaseby
overactivity of the thyroid causes many of the signs and symptoms of Graves disease. Studies suggest... the function of the thyroid, which is a butterfly-shaped gland in the lower neck. The thyroid makes hormones...
Womenshealth.gov Hashimoto's Disease Factsby
. An enlarged thyroid, called a goiter, is often the first sign of disease. The goiter may cause the front... disease is an autoimmune disease that affects the thyroid. It also is called Hashimoto’s thyroiditis...

domain: health


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I think it appropriate to state that Burna Boy is as of now the most sultry artiste in the Nigerian music industry with the immense achievement he assembled in 2018. Scarcely any days back YouTube discharged a short narrative for the King of Afrobeat, Burna Boy about his voyage to Spotlight and the International leap forward.
In the short narrative Burna Boy and his Mother with Grandpa shared a few stories most fans didn’t know about (Watch Video). Well on the present scene of ThrowBack Thursday we present to all of you Burna Boy’s initially discharged tune titled “Freedom“. We beyond any doubt the vast majority don’t think about this.
“Freedom” was said to have been recorded when Burna Boy returned from London in 2010. It was assembled that Burna Boy was captured by London Police for supposedly being a piece of a posse who cut somebody to death, he was attempted as a minor and sent to imprison. Following 11 months, he was discharged and given two months parole in addition to network administration on the grounds of being of ‘good conduct’.
Burna Boy returned home, hit the studio and spilled out his sentiments and torments on this record labeled “Freedom“. Tune in!!!

domain: entertainment


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Community Health Center Announces the Reopening of Obstetrics and Gynecology Services and New OB/GYN Provider
Casper, WY – January 13, 2017– Community Health Centers of Central Wyoming is proud to announce that Dr. Balpreet Singh has joined the newly reopened Obstetrics and Gynecology Department. “We are extremely pleased that Dr. Singh is joining our medical staff and building our OB/GYN Department. As an experienced OB/GYN provider, he is integral to the success of program,” said Karl Radke, MD and Chief Medical Officer. "His focus for quality patient care and OB/GYN experience will be a benefit to CHCCW, and more importantly to our patients. We're privileged to have him on the CHCCW team.”
Singh is experienced with low and high risk pregnancies and postpartum complications. Singh has extensive surgical training and in-office GYN procedures such as, Colposcopy, Cryotherapy and IUD and Nexplanon insertion. Singh practices with minimally invasive techniques for laparoscopic surgeries and has high-level ultrasound training.
Prior to his work as a sole OB/GYN generalist in a hospital-owned practice, Singh spent seven years in New York City completing clinical rotations and training. Singh completed his Obstetrics and Gynecology Residency in 2014 at a robust delivery center, Maimonides Medical Center, in Brooklyn, New York. During his residency, Singh also received training at a wide spectrum of outpatient clinics where he worked one-on-one with patients with a variety of needs. “I am passionate about the field and dedicated to the care of women,” Singh shared. “While at Maimonides, I was fortunate to work with great mentors who trained at Memorial Sloan Kettering and Albert Einstein, and because of their mentorship, I am experienced with a range of surgical approaches and techniques,” stated Singh.
A native of Ontario, Canada, Singh is a proud father and is passionate about health and fitness. Dr. Singh is looking forward to joining the community of Casper and providing OB/GYN services at CHCCW. “I wanted a position which I could work collaboratively with other health care providers. Casper and the community of health care providers meets and exceeds my expectations …” Singh shared. In his spare time, Singh enjoys spending time with his daughter, working out and is looking forward to enjoying the outdoor activities that Casper has to offer.
Dr. Singh will be accepting new patients Monday, February 13, 2017.
To learn more about CHCCW, Dr. Radke and all of our providers please visit: www.CHCCW.org
It is the mission of CHCCW to provide compassionate, affordable and high-quality patient care with a comprehensive range of health care services for residents of Central Wyoming, regardless, of their income, treating all patients with dignity and respect.

domain: medical


The Automotive Research Association of India (ARAI) is building capacities and getting equipped to support the Indian automotive industry in its drive to the 2020 BS VI target. In an interaction with AutoParts Asia, Rashmi Urdhwareshe, Director, ARAI, explained the preparedness from different perspectives.
Q: How prepared is ARAI to support the Indian automotive industry that is fast-forwarding to BS 6?
A: I would address our preparedness from different perspectives – capacity and capabilities. The capacity is needed since all the vehicle segments will have to come for testing. They will rush in the last phase for type-approval. However, work should start now to support them at that time and we are getting ready for that. We are building capabilities for simulation based development platforms. We are also working on engine emission controls, strategies in the emission after treatment, electronic controls and hybridisation, all put together. It includes adaptation of European technology as well.
The two/three wheelers need different approach due to smaller size engines. Passenger car will not pose too much of a challenge for us as there will be technologies available elsewhere. Commercial vehicles have different challenges; we need to have multiple labs to support the industry. We inaugurated a facility last year to support the development of BS-6 engines. Additional facilities are being built in the same campus for electric, hybrid and hydrogen based vehicles. We are standardising the labs to optimise cost and therefore, they can take up development of different kinds of engines.
Q: Where do you see ARAI heading in the next five to ten years?
A: We will be emerging as a competitive global technology partner for the automotive industry. We have talent and facilities – the key ingredients required for development projects globally.
Q: Would you look at setting up a centre outside India?
A: Why not? We see that as a long-term goal; but we would like to work in a synergetic manner. There is no point in creating assets that are not getting utilised. There are partners available elsewhere in the world including Europe who can collaborate with us as we give better services. SIAT helps in identifying the potential partners.
Q: What according to you was the feather in the cap of SIAT 2017?
A: The feather in the cap of SIAT 2017 was the relevance of the theme: Smart, Safe and Sustainable Mobility. The symposium and the forum were the high point. This was for the first time that we received requests from several global organisation to present not only papers but also deliver key-note address.
Q: What was the response to paper presentations?
A: We had to limit the number of papers to about 170. But we had received 1,400 abstracts. It was a mammoth task for us to shortlist the papers to be presented at SIAT 2017.
Q: Any other aspect of SIAT 2017 that made it successful?
A: It was a high point that there was something for everybody. We had very high level plenary sessions which touched and connected with the theme at the macro level and then went into details in parallel sessions. This worked out well as we were able to get many eminent persons to talk on the subjects. One could learn from the forum everything about the global scenario of the automotive industry. The exhibition coupled with the symposium displayed the technologies starting from emission to e-mobility. So it became all under one roof.
Q: Can you summarise the benefits of SIAT editions for ARAI and the automotive industry in India?
A: I will take up the last edition, SIAT 2015. When we reviewed its outcome, we realised that majority of those technologies that were discussed in the forum get implemented in the subsequent two years. The issues discussed, if pursued, would give a roadmap for future development. It is sort of setting the context for the future of the automotive industry. We summed up all the proceedings and submitted it to the Ministry of Road Transport and Highways, in the form of future research areas.
Q: What was the benefit for the industry?
A: Industry sees SIAT as a great learning, networking opportunity, connecting to the right people. We had to stop registration for the forum and exhibition for want of capacity.
Q: But the number of exhibitors was about 10 percent less than last edition?
A: We have stopped taking more exhibitors as we got the feedback from last edition to improve on the layout. This is the best that we could do with the available space in the campus.
Q: What about the autonomous car that ARAI had developed along with Cognizant Technologies and displayed here?
A: Our initiative is to move towards greater technology and intelligent vehicles. The purpose is not to develop autonomous vehicle; instead, it was to lay our hands on the technology with respect to the development of algorithms, technological roadmap and regulations. Besides, it is to take a step by step approach as India will not be ready for absorbing this technology in the near future. However, some of the technologies can go as additional safety feature in the vehicles to come in the immediate future. This will, for instance, on the driver assist system, automatic braking system etc. Evaluating such technologies need to be established. Therefore, we are working on a bottom-up approach as there are actually five-step approach in autonomous vehicle platform


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In the nearly two decades since Anna Deavere Smith created and performed “Fires in the Mirror” (about the Crown Heights riots of 1991) and “Twilight: Los Angeles” (about the LA riots of 1992), her MO has become a whole subgenre of theater. The problem is, most proponents of the interview-based documentary drama Smith pioneered have given it a bad name — they lack her gift for transforming fact into art.
It’s good to have Smith herself back, especially with a show as thoughtful and vibrant as “Let Me Down Easy.”
Whereas her previous pieces focused on specific events, “Let Me Down Easy” is built around an amorphous concept. Smith says it deals with health care, but you won’t hear about pre-existing conditions or public options. Instead, she tackles her topic in the most literal sense: health and care.
Impersonating with uncanny precision 20 real people — their lines are taken verbatim from interviews she conducted — the author/performer explores the connection between body, mind, character and soul.
Some of the subjects, such as Lance Armstrong, are highly aware of their bodies’ power. On the other hand, the late film critic Joel Siegel is betrayed by his, and he uses gallows humor to hide the fear his cancer provokes. Also deceased, former Texas governor Ann Richards says, “A lot of what I feel is in my brain,” but listening to patients, you realize willpower takes you only so far.
And when physicians, hospital administrators and even a musicologist testify about the social and cultural forces that frame our experience of illness and death, it’s hard not to feel overwhelmed.
Tracing a graceful — and, at 95 minutes, nimble — arc from lighthearted and funny to downright philosophical, Smith creates the mosaic portrait of an America disconnected from the cycle of life and unwilling to face death as natural and inevitable.
At the same time, the show, elegantly directed by Leonard Foglia, subtly suggests that we all leave traces of our presence: The props
Smith uses to flesh out her portrayals remain visible after she’s done with them. By the end of the show, the stage is strewn with jackets, hats, glasses, a breakfast tray — as if to say, “It’s not so bad. Memories linger.”

domain: artistic


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Originally Posted by KronoRed
Not only does Paterno need to go, so does the coach who first reported the incident.
'I told my boss' is no defense for not calling the police when you see a child being raped.
Exactly, he seems to be flying under the radar here for reasons I don't understand. In his situation I'm pretty sure I would have done my best to put Sandusky in the hospital. To not even call the police is stunning. That so many people all the way up the chain of command didn't call police is really hard to believe.
There must have been a culture at Penn State to not report things, which is why I think this Deadspin piece is dead on:

domain: news


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PROJECT: Sangath Vastu Shilpa Consultants
ARCHITECT: Balkrishna V Doshi
LOCATION: Ahmedabad, Gujarat, India
The architect and urban planner Balkrishna V. Doshi is one of the most recognized and influential architects of India. But beyond that, their cultural theories and philosophical teachings have placed in a prominent position in the international scene.
The Sangath complex built on the periphery of Ahmedabad, Drive-in Road. Ahmedabad known as Karnavati or Amdavad is the largest city of Gujarat state
“Sangath”, the name given to the complex, means “move together through participation”. Its purpose goes beyond designing homes or offices. Moreover, it covers a wide range of activities including research by the Vastu-Shilpa Foundation, funded by the company Doshi, experimentation in arts and crafts, and studying various technologies of construction or as the architect likes to define… “exploration artistic, social and humanistic dimensions of technology”.
“Sangath” is a powerful architectural manifestation of an independent and original, creative Indian architecture. It is the rediscovery of traditional and local in harmony with the place, with people, and with their past elements.
DESIGNING AND PLANNING:
The dominant architectural forms in the complex are vaulted, obtained from a combination of local traditions and materials with historical examples culturally prefigured such as temples or traditional headgear Hindus.
Sangath buildings complex consists of a set of domes and flat roofs at different heights and different angles juxtaposed to occupy an area of 473 mt. sq. within 2.425 mt. sq. fully walled rectangular field. The building complex built around a large courtyard terrace, which acts as the main entrance. Some of the buildings have sunk below ground level to certain ceilings whereas the domes rise only to eye level.
A small void at the main entrance from where someone can feel the gleams of the whole building gallery. Where some passing through the main entrance, the visitor down some stairs into a room covered by a dome, and the option to climb a flight of stairs to a height of three levels or consequently go through a small hallway to the office of Doshi is present with main drafting room. Finally, in this part of the building, the ceiling plane rises to create enclaves of multiple heights, complementing and releasing between them.
The bottom of the vault in the hall of writing topped with concrete where natural light scatters in space. In the end, thereof an opening that can be appreciated from the entry site visitor makes sense to recover its location along the main axis.
The design studios seen in a double-height volume topped by two domes. In addition, this includes a space with a flat roof that allows natural light until the end of the vaulted areas.
One result of the reintroduction of traditional values is the outdoor amphitheater used for conferences and other meetings.
With the help of a mobile formwork vault “Sangath” constructed with hollow clay tiles embedded in the walls.
Firstly, the outer skin covered with tiles fragmented pieces of waste material from a manufacturer.
Doshi used this traditional technique not only to reduce the heat inside the building but also as an important element of the methodology in the use of waste material.
Moreover, Sangath hopes Balkrishna Doshi to create a connection between nature and the individual. Further, its general form exaggerates the details of nature with its rolling hills, spaces such as caves, terraced land, and water channels with reflective surfaces, which recalls the Salk Institute of Louis Khan.
The structural system is based on poles and combined beams with reinforced concrete slabs. In the recesses of the vaults of the upper floors, iron, and concrete used with high insulation materials such as filling with brickwork. Firstly, the facades covered with tiles or cement and plaster.
Secondly, the interiors characterized by their different shapes and light in different directions. Also, the decor is based on building materials, with the exhibition of prints formwork in concrete ceilings, contrasting with the soft and smooth concrete floor rust-colored red. All materials and 60% of the workforce were local.
Also, cite this article to share: https://architectsempire.com/sangath-ahmedabad-gujarat-india-by-b-v-doshi-the-architects-empire/


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