text: Cells determine the concentration of signaling molecules (e.g., nutrients or toxins in the environment or intracellular transcription factors) by registering associated receptors as “bound” or “unbound” (the inset shows the receptor “readout” over time). As shown schematically for bacterial chemotaxis, a network of reactions transduces the external signal measured by cell surface receptors into a change in concentration of an intracellular protein, which is in turn measured by receptors at the base of the motor. This measurement biases the motor’s direction of rotation, which controls whether the cell runs or tumbles (changes direction). Cells compare the measurement of their external environment at a given time with their memory of it some time ago, and determine the temporal change. The work by Mora and Wingreen  shows that by monitoring the average unbound interval rather than the average binding occupancy, a biological receptor is able to reduce the uncertainty in the measurement process by a factor of two.

domain: chemistry


text:
Filomena Campus returns to PizzaExpress Jazz Club as part of the EFG London Jazz Festival 2016
Award winning jazz vocalist, lyricist and theatre director Filomena Campus will return to PizzaExpress Jazz Club on 15 November as part of the EFG London Jazz Festival 2016. Campus will be joined onstage by her quartet, alongside fellow Sardinian star Gavino Murgia. The evening will see Campus and her quartet present new songs from their forthcoming project Queen Mab, due to be released in 2017. Campus is furthermore lined up at the London Jazz Festival with a vocal workshop at the Barbican on 13 November and a slot supporting Enrico Rava at King’s Place on 17 November.
London Music Masters in collaboration with the Royal College of Music publishes report on impact of community engagement
Music education charity London Music Masters has published the results of a research paper examining the impact of community engagement on professional musicians. Performing musicians remain linked to negative well-being indicators - with orchestral musicians in particular showing a greater tendency to suffer from performance anxiety, injuries and stress during their careers, especially managing portfolio careers. Whereas there is numerous data on the impact on the community, this is the first study of its kind into the impact on the health and well-being of professional musicians.
Raphael Wallfisch performs the Elgar Cello Concerto at the Royal Festival Hall with the London Philharmonic Orchestra and Osmo Vänskä
Cellist Raphael Wallfisch is to perform a concert of Sibelius and Elgar with Osmo Vanska and the London Philharmonic Orchestra at the Royal Festival Hall on 26 October. Firmly positioned at the forefront of championing British composers of the last century, Wallfisch has performed numerous works by British composers including Elgar and Finzi. This concert titled ‘Darkness and Light’ sees Wallfisch perform Elgar’s music again. This is the third of a series of four concerts where Vänskä conducts all of Sibelius’s symphonies.
Gianluca Marcianò calls for talented string musicians to join the Al Bustan Festival Orchestra Academy for the 2017 festival
Enterprising conductor and Artistic Director Gianluca Marcianò announces the creation of the Al Bustan Festival Orchestra Academy in Lebanon with co-founder Maxim Novikov. The objective of the Orchestra Academy is to select players of the violin, viola, cello and double bass and prepare them for the demands of a professional career, with an opportunity to perform at the 2017 Festival with world-renowned musicians. The full programme for the 2017 Al Bustan Festival will be announced on 15 December.
Charles Owen announced as new Steinway & Sons UK Ambassador ahead of Bach partitas album release
British pianist Charles Owen has been appointed Steinway & Sons’ UK Ambassador ahead of the release of his latest album – Bach’s Six Keyboard Partitas – on Avie. As part of his new position, Owen will host a series of three exclusive master classes at Steinway Hall in London. Steinway & Sons explain that the master classes are “aimed at the UK’s next generation of pianists, students will have the opportunity to spend the day at Steinway Hall, to perform a piece of their choice on a Steinway & Sons grand piano and to receive personal feedback and advice from Charles himself, guiding and improving each student’s technical skills and performance.”

domain: news


Choosing the Right Goose Down Pillow for a Good Night's Sleep
Goose down pillows have become increasingly popular due to their superior comfort and support. When it comes to selecting the right goose down pillow for a good night's sleep, there are several factors to consider. In this article, we will discuss the benefits of goose down pillows, how to choose the perfect one, and provide some tips for maintaining their longevity. By the end, you will have all the information you need to make an informed decision and enjoy a peaceful slumber.
Benefits of Goose Down Pillows:
1. Exceptional Comfort:
Goose down pillows are known for their incredible softness and plush feel. The down clusters provide a luxurious support that contours to your head and neck, ensuring maximum comfort. Unlike synthetic fillers, goose down offers a gentle and cozy cushioning that promotes relaxation and deep sleep.
2. Optimal Support:
One of the significant advantages of goose down pillows is their exceptional support. The down clusters have natural resilience, which allows them to bounce back to their original shape after being compressed. This feature is particularly beneficial for those who suffer from neck or back pain, as it helps maintain proper spinal alignment and reduces pressure points.
3. Temperature Regulation:
Goose down pillows provide excellent temperature regulation due to the natural insulating properties of down. These pillows effectively trap the warm air during colder months, keeping you cozy. Conversely, the breathability of goose down allows excess heat and moisture to escape during warmer seasons, preventing overheating and night sweats.
High-quality goose down pillows are exceptionally durable and can last for many years with proper care. The resilient nature of the down clusters ensures that the pillow retains its shape and loftiness over time. Although goose down pillows may have a higher initial cost, their longevity makes them a worthwhile investment in the long run.
Choosing the Perfect Goose Down Pillow:
1. Fill Power:
Fill power refers to the cluster density of goose down, indicating its loftiness and insulation capacity. A higher fill power indicates superior quality and loft, providing better support and breathability. Most premium goose down pillows have a fill power of 600 or above, ensuring optimal comfort and durability.
2. Firmness Level:
Goose down pillows come in various firmness levels, ranging from soft to firm. Consider your personal preference and sleeping position while choosing the right firmness. Side sleepers generally benefit from medium to firm pillows for enhanced neck support, while back and stomach sleepers may prefer a softer pillow for better alignment.
3. Pillow Size:
Selecting the appropriate pillow size is key to ensure a good night's sleep. Standard, queen, and king are the most common pillow sizes. Choose a size that matches your mattress dimensions and fulfills your comfort needs. Additionally, consider factors like your bed size, preferred sleeping position, and the number of pillows you require for optimal relaxation.
4. Pillow Cover:
Opt for a high-quality pillow cover that protects the goose down pillow and enhances its longevity. The cover should be made of a tightly woven fabric to prevent the down from poking through. A thread count of 300 or higher is recommended for durability and comfort. Additionally, look for covers with hypoallergenic properties if you suffer from allergies.
Maintaining Your Goose Down Pillow:
1. Regular Fluffing:
Fluff your goose down pillow regularly to maintain its loftiness and distribute the down clusters evenly. Gentle shaking or punching the pillow helps restore its shape and prevent lumping. This simple routine ensures that your pillow provides consistent support and comfort throughout its lifespan.
2. Air-out Occasionally:
To keep your goose down pillow fresh and odor-free, air it out occasionally. Find a dry and well-ventilated area where you can hang the pillow for a few hours. This allows any moisture or trapped odors to dissipate, ensuring a clean and healthy sleeping environment.
3. Use Pillow Protectors:
Invest in high-quality pillow protectors to safeguard your goose down pillow from stains, moisture, and allergens. These protectors act as a barrier between the pillow and external elements, extending its lifespan and ensuring its cleanliness. Wash the protectors regularly according to the manufacturer's instructions for optimal hygiene.
4. Professional Cleaning:
If your goose down pillow requires a deep clean, it is best to opt for professional cleaning. Many dry cleaners offer pillow cleaning services specifically designed to handle down-filled products. Professional cleaning not only removes dirt and stains but also rejuvenates the pillow, maintaining its suppleness and loftiness.
Choosing the right goose down pillow is essential for achieving a restful and rejuvenating sleep. Consider the benefits of goose down pillows, such as their comfort, support, and temperature regulation. When selecting a pillow, pay attention to factors like fill power, firmness level, size, and pillow cover. By following proper maintenance tips, you can ensure the longevity and performance of your goose down pillow. Invest in a high-quality goose down pillow today, and experience the luxury and comfort it brings to your night's sleep..Rongda is a professional down feather manufacturer and supplier in China, specializing in Duck Down, Goose Down, Duck Feather and Goose Feather, welcome to contact us!


text:
price advantage enjoyed by independent imports from Europe over cars sold through
‘official’ UK franchised dealerships is now negligible as the majority of Internet-based
importers begin to increase prices and UK dealers become more competitive, says
the latest car price check report from Autohit plc.
The analysis is based on the top 14 models searched by 80,000 internet car
buyers on the Car Price Check web site between November 2000 and March 2001.
The report also highlights the wide fluctuations in price on a month-by-month
basis between the two sources, with UK sources supplying 46 percent of the sample
cheaper than European retailers in December alone.
However, UK dealers are being warned that it is folly not to adopt aggressive
pricing from the start of any negotiation.
"From the raw data we have, it is clear that dealers appear to be waiting
for consumers to find the best price before they react competitively.
“Consumers reject most initial dealer quotations if they are not immediately
competitive, a sad reflection that some dealers have failed to recognise that
they may not get that second chance to make a first impression with a digital
car buyer," said Autohit CEO Steve Evans.
Although there may still be a gap between European- and UK-sourced list prices
at present, when it comes to actual transaction prices the difference is far
from being a gulf. In more than 41 percent of cases, the saving offered by the
importer over the average UK dealer price was so low as to raise a question
mark over the benefits of buying from Europe.
Some UK sourced cars are now significantly cheaper to buy than those from the
continent. For example, the Citroen Xsara Picasso showed a £1,971 ($US2,800)
price difference (or 14.29 percent saving off the manufacturer’s list price)
between the most competitive UK supplier and the most competitive importer.
A similar case can be made for the Mercedes E Class and Renault Megane Scenic.
Two suppliers who have consistently championed the consumer and the attraction
of importing from Europe, Carbusters (operated by the Consumer Association)
and Virgin Cars, have actually recorded a rise in transaction prices during
the period for the majority of models studied, Autohit claims.
Carbusters now supplies 72 percent of the sample at a higher price today than
in November. It is similar for Virgin Cars whose transaction prices have increased
for 88 percent of the models it was able to supply from the sample. Virgin Cars
was also more expensive than the average UK dealer price – not necessarily the
lowest price obtainable – on 60 percent of the models analysed.
This trend compares to the recorded fall in prices of 66 percent for all the
UK dealer sourced models during the November to March period. Similarly, the
other major brand-led etailer, Direct Line’s JamJar operation, recorded a fall
in prices for 80 percent of the models it was able to source.
Significantly, the analysis demonstrated the volatility of new car prices with
wide fluctuations in actual transaction costs throughout the four-month period.
This trend was recorded for all suppliers whether Internet, traditional or importer
and indicates the increased consumer-driven competitive pricing that is now
part of the UK motor retail landscape.
When it comes to lower prices month-on-month, importer Oneswoop has demonstrated
a spectacular willingness to consistently increase the discount it offers over
UK list prices, so much so that it was the cheapest supplier for 66 percent
of the models sampled.
Yet, even on those models where Europe is consistently the cheaper source –
e.g. the Peugeot 206 2.0 GTi – the UK dealer has dramatically bridged the gap.
Although, the price advantage of buying the model from Europe fell from £1,500
($US2,100) in November to only £794 ($US1,130) in February, it has again
opened in March as a result of some apparently aggressive pricing from Carbusters
with an effective discount of 14.77 percent on offer.
"The clearest message for the industry has to be that competitive forces
and consumer pricing benefits can and do change dramatically. Such movement
is happening over a short period of time and should therefore be monitored,"
"More than ever, manufacturers and franchised dealers need to understand
how their product is being priced and sold to the UK consumer.
“The Internet has given the consumer access to knowledge. Manufacturers and
dealers need to make that search for knowledge a part of their marketing mechanism."
To read an Autohit feature article, please follow the
To view related research reports, please follow the links

domain: finance


text:
Intense fighting between the military and Islamist militants in northern Nigeria is reported to have killed at least 185 people, however the army has disputed this figure.
Rocket-propelled grenades and heavy gunfire bombarded the remote town of Baga near the border with Chad for hours on Friday evening, officials say.
Some 2,000 homes were reportedly destroyed, causing many of the deaths.
Nigeria faces a long-running insurgency in its predominantly Muslim north.
The Boko Haram insurgency has left thousands of people dead since 2009.
‘Markets burnt’Residents of Baga fled into the bush and only returned on Sunday afternoon to find much of the town destroyed and human and animal corpses strewn through the streets.
One local journalist said this marked a significant escalation in the insurgency in the area, with the militants using heavier weapons than in previous attacks.
One resident, Bashir Isa, told Associated Press: “Everyone has been in the bush since Friday night; we started returning to town because the governor came.
“To get food to eat in the town now is a problem because even the markets are burnt. We are still picking corpses of women and children in the bush and creeks.”
Residents said most of the bodies had been burned beyond recognition in blazes that had destroyed much of the town.
Local official Lawan Kole said that 185 people – including civilians, members of the security forces and attackers – had been buried.
However, Borno state military spokesman Lt Col Sagir Musa told the AFP news agency that such a high number of deaths was “unthinkable”.
“On my honour as an officer, nothing like that happened.”
Correspondents note that the Nigerian military often plays down the number of people killed in clashes with militants.
An unnamed local official told AFP that dozens of people had been killed in the fighting.
Communications with parts of northern Nigeria are difficult since mobile phone masts were destroyed by militants.
Boko Haram wants to carve out an Islamic state in northern Nigeria.
Its name in the local Hausa language means: “Western education is forbidden”.

domain: sociology


text:
Five people died when a small plane on the way from the national park Masai Mara in Kenya crashed, police said.
“There were five people aboard the plane and they didn’t survive,” said police chief of the Rift Valley region, Edward Mwamburi.
The nationality of the fatalities is not known, but the small Cessna plane was on its way from the Masai Mara to the town of Lodwar when it crashed. The cause of the accident is not known.
Hundreds of thousands of tourists from all over the world visit Masai Mara annually, known for its rich wildlife.

domain: geography


text:
Parsons Modern Sans is created as university homework project. The brief was to reinvent an old, well known font by modernizing it and trying to improve its flaws, if any.
Parsons Modern Sans is inspired by the Parsons font - designed for "BB and S" in 1917 by Will Ransom. It was based on the distinctive style of lettering he had been doing for advertisers in that city, and was named for I.R. Parsons, advertising manager of a Chicago department store. It's nearly monotone, but with a hand-lettered quality. It has unusual half-serifa and unique forms to a number of letters. The caps M, N, U and Y have a lowercase design.
Parsons Modern Sans remover the serifs, in order to modernize a bit the original font, and keeps the idea of the unique forms to some letters, as well as the lowercase caps of M, N, U and Y. So far, Parsons Modern Sans comes only in its regular style, and is free, as a contribution to the open-source community.

domain: artistic


Windows 10 ARM runs faster on Mac with M1 than Surface Pro X
Twitter user Sunshine Biscuit at scale published the results of testing the performance of the new MacBook Pro 13 on the M1 chip with Windows 10 installed for ARM processors. It turned out that the system performs better on an Apple computer than on the native Surface Pro X.
At the moment, Apple computers with Apple Silicon processors do not officially support Windows 10. But last week, a German developer Alexander Graf was able to run Windows on an M1-based Mac using the QEMU virtual machine. Moreover, this is not emulation, but full-fledged native virtualization, which allows you to achieve good performance. However, so far the running OS from Microsoft on Mac is not always stable, and some of the system's functions are not available.
Enthusiasts have tested the performance of computers at GeekBench. So, running with QEMU Windows 10 on a MacBook Pro 13 showed a result of 1288 points in a single-core test and 5449 points in a multi-core test.
This is significantly more than in the Microsoft Surface Pro X based on the Microsoft SQ2 processor with 16 GB of RAM - their testing gave a result of 799 points in single-core and 3089 points in multi-core tests.
For comparison: in its own macOS 14 Big Sur, the laptop gives out 1737 and 7549 points, respectively.
Thus, the Apple computer was almost twice as productive. This indicates that, in the first place, the performance of the Mac on the M1 is not due to the optimization of macOS 14 Big Sur, but to the hardware itself.
The developer was able to run Windows ARM64 Insider Preview on Mac by virtualizing it using Hypervisor. framework. Apple itself claims that this method allows you to work with virtualization without the need to write KEXT kernel extensions. This allows the guest code to be executed directly on the central processor. This is what made it possible to achieve such good Windows performance on Apple Silicon.
It is likely that if the Windows 10 ARM version is adapted for Apple's new chips, the new Macs will become the most powerful devices to run that version of the system. Earlier this was stated by the senior vice president of software development at Apple Craig Federighi: according to him, the company's computers are ready to work in the Windows environment, and the adaptation of the OS is completely on the shoulders of Microsoft.


Visual control of the wash process
Washer Disinfector Test Soil (2304)
Test Soil is a standardised visible soil with proteins, sugars and fats (as the Edinburg Soil) simulating the normal contamination from the operating room.Apply on the instruments to wash, let dry and wash. A visible clean instrument confirms a good wash process. Rests of red soil proove the opposite. Recomended for periodical check.
STF Load Check (Indicator & Holder) (2315 & 2316)
A pre-printed Test Soil to be embarked in a production wash run.A clean sheet proves good wash conditions. Test result is easy to archive. Recomended as a process indicator for each run.
STF MIS-Lumen Test (HX100 & HX101)
Minimal Invasive Surgery (MIS) has taken a substantial portion of the surgical program. The narrow lumens of these instruments have brought a challenge for the washing process. This test offers a challenge device and a visual check for a correct washing process for these instruments.
Ninhydrin Protein Detection Test (2370)
A full test kit to reveal non-visual proteine residual on washed instruments.
ResiTest & ResiTest Pen (3369 & 3371)
A fast test for non-visual proteine residual on washed instruments, also available in all-in-one test, results in 10 seconds, no lab techniques required.


Nowadays, there are so many products of whirlpool gas cooktop knobs in the market and you are wondering to choose a best one.You have searched for whirlpool gas cooktop knobs in many merchants, compared about products prices & reviews before deciding to buy them.
You are in RIGHT PLACE.
Here are some of best sellings whirlpool gas cooktop knobs which we would like to recommend with high customer review ratings to guide you on quality & popularity of each items.
536 reviews analysed
1. 5x W10594481 Knob Stainless Steel Stove Control Knob Replacement for Whirlpool Stove/Range WPW10594481, W10594481, W10698166
W10594481 5 Knob Stainless Steel Stove Control Knob Replacement for Whirlpool Stove/Range WPW10594481, W10594481, W10698166 Replaces WPW10594481, W10594481, W10698166 Fits WCG97US0DS00, WCG97US6DS00
2. Lifetime Appliance 4 x W10594481 Knob for Whirlpool Stove/Range
- ✅ Part Numbers: W10594481, WPW10594481, AP6023301, PS11756643, B01KR8F5EU
- ✅ Quantity: 4 x Ultra Durable, Quality Replacement Knob for Whirlpool Stove/Range
- ✅ NOTE: Please be aware even though “W10594481” is imprinted on the back of your knob, please confirm the model number and stem length before ordering. The print on the back of your knob may be incorrect.
- ✅ Fits models beginning with: WCG97 and will NOT fit models beginning with WEG7.
- ✅ NOTE: The length of the stem is approximately 1/2 inch. If your stem is 7/8″ inch, then you need W10818230 instead and this knob won’t fit. If your knob has “Off”, “Ignite”, etc. you will need W10766544 instead.
Part Numbers: W10594481, WPW10594481, AP6023301, PS11756643, B01KR8F5EU
Replacement Knob for Whirlpool Stove/Range
3. Ultra Durable W10594481 Knob STRONG Material Replacement Part by Blue Stars – Exact Fit for Whirlpool Stove/Range – Replaces WPW10594481 AP6023301 PS11756643 – PACK OF 5
- MODEL NUMBER: W10594481 Cooktop Knob – PACK OF 5
- PREMIUM QUALITY: These knobs are made of strong and high resistance material to enhance durability, support heavy duty and ensure long-lasting operation
- EASY TO INSTALL: It is made exactly fit for most top name brands (Whirlpool, Amana) and replaces part numbers: WPW10594481, AP6023301, PS11756643
- SAVE TIME SAVE MONEY: Inexpensive way to fix or repair a cooktop
- MONEY-BACK GUARANTEE: For any reason, you’re not completely satisfied, you can ask for a replacement or FULL refund, no questions asked
4. Ultra Durable Lifetime Appliance Parts W10594481 Knob for Whirlpool Stove/Range
- ✅ Part Numbers: W10594481, WPW10594481, AP6023301, PS11756643, B01KR8F5EU
- ✅ Ultra Durable, Quality Replacement Knob for Whirlpool Stove/Range
- ✅ Premium Quality: We utilize premium, highly durable materials guaranteed to exceed OEM specifications
- ✅ LAP Guarantee: For any reason you’re not completely satisfied, you are welcome to return the product for a full refund, no questions asked
- ✅ Fits models beginning with: WCG97. NOTE: This item looks very similar to W10818230, W10766544 and W10826855, so please be sure you are ordering the correct part #. If you are unsure of the correct part to order, please let us know your stove’s model number and we will gladly confirm for you.
Compatible with Whirlpool Oven, Range or Stove
Replaces part numbers: W10594481, WPW10594481, AP6023301, PS11756643, B01KR8F5EU
If you are unsure our replacement part will fit your appliance model, we are happy to help! Please let us know (1) your model number and (2) the item in question via the following link:
Whirlpool, Samsung, General Electric, Frigidaire, Kenmore, Sears, Maytag, KitchenAid brand names and logos are the registered trademarks of their respective owners. Any use of the above brand name or model designation for this product is made solely for purposes of demonstrating compatibility.
5. W10594481 5pcs stainless steel cooker stove control knob Compatible with Whirlpool WPW10594481, AP6023301, 3281332, W10594481, W10698166, PS1175
- [Applicable Models] WPW10594481, AP6023301, 3281332, W10594481, W10698166, PS1175. The burner knob W10594481 gives you more control over the burner heat on the surface of the stove.
- [Includes Packaging] This product is compatible with Whirlpool products.This package contains only 5 W10594481 control knobs.
- [Material] The product is made of durable metal material, high-strength material is not easily damaged, high-quality stainless steel, stem is reinforced with aluminum ring, tested by the manufacturer to meet and/or exceed OEM specifications.
- [Design] The W10594481 knob is a manually controlled manual component that has less power than other shaped dial knobs. The knob has a metal insert to prevent flaking.
- [After-Sales Guarantee] 100% Money Back Guarantee – For any reason, if you are not satisfied, you can request a replacement or a full refund. Your satisfaction is our motivation. If you are not satisfied with the product, please contact us in time. We will show you a sincere attitude and a satisfactory solution.
6. Tuuliv W10594481 Knob for Whirlpool Stove/Range 4 Pack
7. W10594481 5pcs Stainless Steel Cooker Stove Control knob Compatible with Whirlpool WPW10594481, AP6023301, 3281332, W10594481, W10698166, PS1175
- Replacees Part Numbers WPW10594481, AP6023301, 3281332, W10594481, W10698166, PS1175.
- Easy to Install
- exactly made to fit your with Whirlpool control knob.
- Premium Quality
- ensure durability and long last use.
- Saves time and money
- cheap way to fix a stove/range.
- Complete set
- cooker stove control knob needed for the cooktop.
Brand Compatibility: Whirlpool
Part numbers: WPW10594481, AP6023301, 3281332, W10594481, W10698166, PS1175
You will get 5pcs stainless steel cooker stove control knob
8. Jetec 4 Pack Black Control Knobs Replacement with 12 Adapters for Oven/Stove/Range, Wide Application
- Adapter size: each temperature control knob come with 3 piece adapters, 12 pieces adapters in total, the inner diameter measures approx. 6-8 mm/ 0.24-0.31 inch, convenient for your installation and daily usage
- Knob size: each range control knob measures approx. 1.54 inch/ 39 mm in diameter and 0.43 inch/ 11 mm in diameter of insert knob ,make sure the insert size(0.43inch/11mm in diameter) is suitable for your machine.
- Package includes: 4 packs control knobs and 12 pieces adapters in 2 different styles, 4 long and 8 short, 16 pieces in total, sufficient quantity for you to replace the old set
- Wide application: the control knobs is designed to fit many applications, such as most gas and electric stoves, ovens and ranges, also suitable for campers, camping appliances, etc.
- Work with: you can apply these stove burner knobs to stove, oven and range
- Warm note: the size of the shaft in your stove or oven should match the “D” posts inside diameter of our control knob, only works under this condition
9. (4 Pack) Rayhoor W10339442 Gas Range Knob Black Replacement Part for Whirlpool Range/Stove/Oven- Replaces WPW10339442, PS3507188
- 【Perfect Replacement】 Our 4 Pack W10339442 Gas Range Knob replaces part numbers: W10339442, WPW10339442, AP6019877, PS11753188, WPW10339442VP, B0156NFANC
- 【Widely Applicable】Compatible with Whirlpool, Maytag Range / Stove / Oven. Product Dimensions:2.05″Φx 1.54″H (5.2 x 3.9cm).
- 【Premium Quality】This high-quality exact equivalent meets or exceeds original manufacturer specifications. It has a durable plastic construction for reliable use.
- 【Save Time & Money】Saves you a service fee from the appliance guy! Inexpensive way to fix or repair a range.
- 【Lifetime Warranty】If there is anything you are not satisfied, please feel free to contact us , and we will offer you a replacement or full refund. High-quality products and service is our priority.
Rayhoor’ Knob is sometimes known as a valve knob, works for a range, oven, or stove. This knob accepts a D-shaped shaft. No tools are required for completing this repair. A Range Top Surface Burner Knob, directly fit replacement for your worn, broken or missing knob.
Replaces the following parts:
W10339442, WPW10339442, AP6019877, PS11753188, WPW10339442VP, B0156NFANC
Compatible models include but are not limited to:
WFG320M0BB0, WFG320M0BS0, WFG320M0BW0, WFG505M0BB0, WFG505M0BS0, WFG505M0BW0, WFG510S0AB0, WFG510S0AB1, WFG510S0AB2, WFG510S0AD0, WFG510S0AD1, WFG510S0AD2, WFG510S0AS0, WFG510S0AS1, WFG510S0AS2, WFG510S0AT0, WFG510S0AT1, WFG510S0AT2, WFG510S0AW0, WFG510S0AW1, WFG510S0AW2, WFG520S0AB0, WFG520S0AB1, WFG520S0AB2, WFG520S0AS0, WFG520S0AS1, WFG520S0AS2, WFG520S0AW0, WFG520S0AW1, WFG520S0AW2, WFG524SLAB0, WFG524SLAB1, WFG524SLAB2, WFG524SLAS0, WFG524SLAS1, WFG524SLAS2, WFG524SLAW0, WFG524SLAW1, WFG524SLAW2
Fixes the following symptoms:
Selection will not set;
Will not turn;
Will not stay on.
Material: ABS plastic
Product Dimensions: 2.05″Φx 1.54″H (5.2 x 3.9cm)
Quantity: 4 Pcs
This is not original product, the mention of any related model designation above is only for purposes of demonstrating compatibility.
10. Ultra Durable KN002 RKE Universal Electric Range Knob Kit Replacement by Blue Stars – Exact Fit for Most Range/Oven Brand – Replaces AP5641247 MA-XP6 RK103
- MODEL NUMBER: RKE Electric Range Knob Kit – PACK OF 5
- FULL KIT SET: Includes (5) knobs
- (4) surface inlays CCW
- (4) surface inlays CW
- (1) thermostat inlay 150° – 500° w/broil
- (1) CW to ON inlay
- (5) each of blue, green, gray, red and yellow inserts
- EASY TO INSTALL: It is made exactly fit for most top name brands and replace part numbers: 61201, AP5641247, KN002, MA-XP6, RK103, TJKN002, TJMA-XP6, TJRK103
- PREMIUM QUALITY: The replacement part is made from durable high quality material and well-tested by the manufacturer
- MONEY-BACK GUARANTEE: For any reason you’re not completely satisfied, you can ask for a replacement or full refund, no questions asked
The RKE Electric Range Knob Kit is designed to meet or exceed OEM specifications.
Replaces part numbers: 61201, AP5641247, KN002, MA-XP6, RK103, TJKN002, TJMA-XP6, TJRK103
Count on our RKE Electric Range Knob Kit Replacement for an unrivaled mix of durability, convenient functionality, and great value for money. Click ‘Add to Cart’ now!
If you are unsure our replacement part will fit your appliance model, you can ask us in Customer questions & answers section or contact us by visiting the Blue Stars LLC storefront — click the “Blue Stars LLC” on a product page to get to the storefront — then click the “Ask a question” link under Further Information. Select your reason, and then tell us about the question.
By our suggestions above, we hope that you can found Whirlpool Gas Cooktop Knobs for you.Please don’t forget to share your experience by comment in this post. Thank you!


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The Best Babymoon Destinations in the World, Tried & Tested!
Best Babymoon Locations for Families
If you already have a child or children, and yet you still want to head to something close to a relaxing babymoon getaway, these are the places you should have on your list, although I think all of them would still make perfect luxury babymoon destinations for just adults too.
Best Babymoon Destinations for Adults-Only
As both of our child-free babymoon destinations were actually also suitable for families, I turned to a few of my blogging friends to ask them where they went on their adults-only babymoons and they're suggestions are fab, and not necessarily the usual suspects!
Here we go, firstly with Emily from Luxury Backpack who went to Key West on her babymoon.
We decided to head to Key West for a luxurious babymoon last year. Nestled down at the southernmost point in the Florida Keys, this town has so much character and charm. The buildings are stunning, the people friendly, and there is so much choice when it comes to drinking and eating. We explored a little, but also spent a lot of time reading and drinking virgin mojitos by the pool.
Despite the plethora of hotels in Key West, where to stay was an easy choice. I had wanted to stay at the iconic Southernmost House Hotel for ages, so a special babymoon weekend was the perfect excuse! It is an stunning hotel that has a personal luxurious feel, beautiful rooms with four-poster beds, and a pool with ocean views. It will stay firmly in my memory forever.
Getting to Key West is fairly straightforward despite its remote location. You can fly to Miami and drive the 3.5 hours south through the Keys along the scenic Overseas Highway. You might even be tempted to spend a night in Islamorada or Marathon to break up the trip. Otherwise Key West has a small airport you can fly to from many domestic airports. I cannot recommend the Florida Keys and Key West enough for a memorable, relaxing, tropical babymoon!
You can follow Emily's family travels on Instagram.
We visited Amangiri in Utah, USA on our babymoon and we absolutely loved it. The resort is like something out of a James Bond movie. It sits within 600 acres of the Colorado Plateau in splendid solitude. As you approach it, the resort looks a bit like a bunker, with it’s straight, concrete lines against the red rocks of the desert around it. It's stark, yet strangely beautiful. It's certainly a great babymoon destination in the USA.
You may be in the middle of nowhere, but don’t be mistaken. This is a seriously luxurious hotel and Aman is one of the world’s best hotel chains. The restaurant is exquisite - you eat seasonal produce (carefully selected to be mother-to-be friendly!) alongside grand floor to ceiling windows that make you feel like you’re sitting in the middle of the desert. There’s an incredible 25,000 foot spa which offers tranquil pools to relax by and massages for mothers-to-be. If you’re feeling more energetic, there are slot canyons you can walk to.
One of our favourite areas to chill out in was main pool area. It’s cut into a lofty rock escarpment and the main pool curves around this. So as you swim, you’ve got an elegant, modern resort on one side and on the other a craggy rock face that’s millions of years old. We had a wonderful stay at Amangiri and would love to return (but not with the kids)!
Best Places for Babymoon City Break
Yes, I'm biased because it's my home, but I truly think Amsterdam is a great babymoon destination if you're pregnant. It's easy to get around because it's relatively small and compact (compared to the likes of London or Berlin) and very importantly, it's flat! So if you were thinking of walking a lot, this is a great place to do it with minimal impact on your body (and potentially swollen feet!). That said, public transport is very user-friendly and if you're feeling really brave you could cycle around too (and you'll definitely see lots of local women with bumps on two wheels - I may be one of them!) There's plenty to do in Amsterdam to keep you busy, but also lots of beautiful hotels that would make great luxury babymoon destinations if relaxing is just as important. (I would recommend Waldorf Astoria and Conservatorium if you're looking for a five-star hotel with an excellent spa, or for a slightly lower price tag but still plenty of comfort look at The Pullitzer or The Hoxton). Amsterdam is also a great destination if you choose to go away for your babymoon in the cooler months of winter or autumn. I've written lots of posts that will help you plan your Amsterdam babymoon, but these few should be the best places to start: Best Hotels in Amsterdam for all Budgets and Tastes, 100+ Free Things to do in Amsterdam, and Best Photo Spots in Amsterdam.
If you've already been to Amsterdam a few times but yet fancy the same kind of scenery and atmosphere, then think about going to Utrecht or Rotterdam, the former is like a smaller version of Amsterdam, while the latter can offer a more urban and city-scape feel but with still plenty of hidden gems to uncover. Here's my city guide for Rotterdam.
While I wouldn't recommend visiting during the peak summer months (because of the heat and numbers of tourists) Lisbon is a perfect babymoon city break destination, especially if you're heading away with some girlfriends. The city is beautiful and fascinating enough just to wander around (for the tiles on the houses alone!) but you can easily escape the city by hopping on a train and heading out to the coast or to do a tour of the famous palaces at Sintra. There are also some fab luxury hotels with pools and spas to enjoy at very competitive prices (Olissippo Lapa Palace and Porto Liberdade are ones I hear highly recommended) and please make sure you watch the sun go down over the city, because the light is incredible! Check out my city guide for Lisbon if you're heading there with good friends to plan a great Lisbon babymoon.
Speaking of Portugal, Funchal is not going to be a logical choice for many people's city break babymoon as it's quite a faff to get to (with not many direct flights) but once you're there, Funchal in Madeira has everything; a city to explore, beaches to lie on, and several resort style hotels that can offer you plenty of comfort and relaxation. The rest of the island is also worth discovering which you can easily do by hiring a rental car for a day and going on a road trip. Sadly, you won't be able to try the island's famous (and highly alcoholic!) drink poncha, but you can enjoy fresh seafood and beautiful sunsets with a mocktail or no-alcohol beer! I stayed in the Hotel Porto Mare in Funchal and found it a really lovely resort-like hotel that had a great city and waterfront location.
One city I'm desperate to return to with my partner is Ljubljana and while I'm not planning on getting pregnant again after this my second time, I would definitely say Ljubljana would make a great city break destination. The mostly pedestrianised old city centre with pastel-shaded houses and cobbled streets is perfect for gentle exploring, but if you feel braver you can make the walk up to the castle (or alternatively catch the funincular up!) and enjoy the best views of the city and surrounding countryside. Ljubljana surprised me with its small size but big personality with plenty of lovely restaurants, cafes and lunch spots, and trendy areas to find vintage shops and street art. My choice of hotel for a weekend city break babymoon in Ljubljana would be the Intercontinental as it offers a lot of luxury and an excellent location. Read my full Ljubljana city guide here.
Bologna is the ultimate babymoon destination for foodies! The home of slow food and the culinary capital of the region that brings us the Italian delicacies ragu alla bolognese, (and not spaghetti bolognese!), lasagna, parma and mortadella hams, balsamic vinegar, ravioli, and parmegiana reggiano, among many others, will satisfy hungry pregnant appetites (food restrictions aside!) and any lucky non-pregnant partners can also enjoy the fine wines the region produces. Away from food, there is plenty to see and do in Bologna, and the surrounding region, but even just wondering around the city centre under the famous porticoes will be entertaining enough.
If you live on the other side of the world in Asia or Australasia, then all these European cities are going to be a bit far for you to get to but there is one place you could consider: Singapore! We've spent many a weekend in Singapore during our travels and while the last few times were with a toddler, it's never failed to be one of my favourite cities for exploring with just my partner. There's history to learn, varied museums to enjoy, and countless good restaurants and bars to spend your evenings in. It's also one of the few places where (as a pregnant woman or otherwise!) I really trust the street food so I wouldn't feel I'm missing out on that experience either. Here's my guide to Singapore with a toddler, but there are still some lovely ideas for things to do if your little one is still in utero, also I would definitely recommend the Fullerton Bay where we stayed, and you MUST do a high tea there too.
Another cool destination to consider for those in the Southern Hemisphere (or not, if long flights don't put you off!) is Cape Town. I actually did visit Cape Town when I was pregnant - around seven weeks! - as I found out I was expecting the day before we boarded our flights to a friend's wedding in Franschoek. We spent a week and a half in Cape Town in total staying in an Airbnb in the V&A Waterfront area. I took part in a number of walking tours of Cape Town and the Woodstock area which is famous for its street art, and my partner and I went on a couple of road trips to Cape Point National Reserve, and down to Boulders Beach to see the penguins. While the flight was long, the good thing about Cape Town if you're travelling from Europe is you are roughly in the same time zone, and you can jump from winter to summer if you want! The are a few really brilliant luxury hotels you could consider include The One & Only, Victoria & Alfred and the Radisson RED.
Now, over to my blogging friends for their suggestions for their best babymoon locations if you fancy a babymoon city break:
Lyric, from Asher & Lyric, went on a babymoon to Paris with her husband Asher and their toddler and aside from this adorable photo it sounds like it was a really special trip.
You wouldn't think it would be the best place for a babymoon but my husband, toddler and I went to Paris for the babymoon of our second child and it was fantastic. For us, Paris is one of the most enchanting cities in the world and our personal favorite. It made for an epic babymoon because it was so nourishing for all of my senses. Everywhere we turned there was something incredible to eat, drink, or see. And there is no better time than while pregnant to have the most mouth-watering pastries that have ever been baked fresh out of the oven!
We made a point to visit three Michelin rated restaurants, and loved sampling their eight to sixteen-course degustations! As a mother to be (for my second time) I felt especially connected to the human experience and how every soul comes onto this earth for their own special purpose.
Paris was the perfect city to remind me of how many incredibly talented artists, architects, musicians, scientists, and thinkers have graced this earth throughout the centuries and have used their talents to help uplift and transform society. I am always thankful for my time in Paris! And especially for being there as a new mama to be. :)
Shelley from Travel-Stained went to a city I would never really consider for a babymoon, Kuala Lumpur, but it does sound like it was perfect and a lot of fun!
Kuala Lumpur, Malaysia might not be the first place you think of for a babymoon, but it's actually the perfect destination for an expectant mother. Many pregnant woman are always ravenously hungry or have unusual new tastes, and this is a foodie destination, if ever there was one.
I made sure to hit both ends of the gastronomic spectrum during my stop in KL by visiting both a crazily chaotic food street AND a heritage hotel for high tea. At Jalan Alor food street, we wandered from stall to stall eyeing a never ending selection of tasty treats, before finally deciding on lok-lok from Fat Brother Stay and Wong Ah Wah's famous chicken wings.
But at 86 year old heritage hotel, the Majestic Kuala Lumpur, I basked in the super soothing environment with a classic high tea. I indulged in cup after cup of Gold Blend Tea from the Cameron Highlands and a tea tray full of warm scones, finger sandwiches and delicious desserts. It was an absolutely perfect respite for this mama to be.
The Orchid Room is the most popular area to enjoy High Tea at the Majestic Hotel, due to its incredible beauty. However, I recommend just popping in to take a few pictures, and then spending the rest of your visit in the Tea Lounge. It has comfy couches and plush armchairs that your aching back and swollen feet will thank you for.
Please let me know if you have any other suggestions for top babymoon destinations in the comments. I'd love to hear where you went and what was so special about you babymoon. And remember to check out these babymoon travel tips and ideas too.
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The first travelers and crew members were welcomed to Miami International Airport's new international arrivals hub early Tuesday. The airport's deputy director, Ken Pyatt, talks about its "new front door."
The first travelers and crew members were welcomed to Miami International Airport's new international arrivals hub around 4 a.m. Tuesday morning.
The hub's opening is part of the final phase of a long-awaited multi-billion dollar MIA improvement project.
"This is a great day for MIA because our new front door to the world has just opened," said Deputy Director of MIA Ken Pyatt.
The $180 million North Terminal features a brand new 3-level, 400,000-square-foot center twice the size of the existing Concourse E. It can process 2,000 international passengers per hour - twice what the old facility could handle. The new space accommodates a record-breaking number of passengers.
"That's the whole point, our growth has been phenomenal," Pyatt said. "We are the fastest growing airport in the United States right now."
It features a new greeter's lobby and a 72-lane federal inspection area. MIA is one of six U.S. airports with six lanes dedicated to expedited Global Entry processing for pre-approved, low-risk travelers registered with U.S. Customs and Border Protection.
Airport officials expect that passenger processing times will improve by a minimum of twenty minutes.
"Where they check all your identification coming back to the country is a bit different, fast," said traveler Terry Shelby who flew in from Rio De Janeiro.
"It smells like a brand new apartment," said American Airlines flight attendant Ken Dealba.
The North Terminal project will be completed by March 2013 and feature five more baggage carousels and three gates.


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The Menlo Park Sidewalk Fine Arts & Crafts Fall Fest turned a length of Santa Cruz Avenue into an outdoor gallery last weekend. Art enthusiasts admired the paintings, sculptures, furniture, clothing and jewelry brought by over 90 artists to the festival.
The event takes place annually as part of Pacific Fine Arts Festivals. Founded in 1980, Pacific Fine Arts Festivals organizes arts and crafts festivals throughout California with artists from the West Coast and beyond. Though the Menlo Park Sidewalk Fine Arts & Crafts Fall Fest ended on Oct. 5, you can catch the 24th annual San Carlos Chamber of Commerce’s Art & Wine Faire on Oct. 11 and 12.

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Deepika Padukone shared a throwback picture of herself with father Prakash Padukone on his 62nd birthday
Deepika Padukone will co-star with Irrfan Khan in the untitled film to be produced by Vishal Bhardwaj
Deepika Singh and Rohit Raj Goyal welcomed their first child on May 20
Deepika Padukone is ready to collaborate with filmmaker Vishal Bhardwaj for his next project
Deepika Padukone and Ranveer Singh returned to Mumbai on Friday afternoon after visiting the Golden Temple in the morning
Deepika Padukone and Kiara Advani were spotted at the Mumbai airport on Tuesday and both the actresses sported similar outfits.
Deepika Padukone And Jacqueline Fernandez: Happy Faces At A Busy Airport
What Deepika, Vidya And Tapsee Did Mid-Week

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Drawn to an alluring beauty he meets aboard a train, a Russian writer follows her into an elegant casino. There he is intrigued by the obsessive life she and her father share, risking their fortunes and their futures on the spin of a roulette wheel.
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JUS-4474 Safety in the Justice Environment (3 Credits) An exploration of health and safety issues in a justice environment. Areas to be considered: legislation, workplace safety issues, accident investigation techniques and related documentation, and educational programs related to health and safety issues. DFS environment is required. Not available for supplemental.Work Integrated Learning (3.0)Equivalent to COR-4474, COR-474, JUS-4474W.Requisite courses: Take JUS-3388 (Required, Previous).
JUS-4474 Safety in the Justice Environment - 3.00 credits

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Soundwaves presents brand new editions of 10@10, the beloved long-running radio show that features ten great songs from one great year, as well as numerous samples of political, historical and pop culture happenings. Hosted by Dennis Willis and featuring original 10@10 host Dave Morey, Soundwaves 10@10 is the ultimate pop culture celebration loved by thousands of devoted fans.
Ten Great Songs from One Great Year!
On today’s edition of Soundwaves 10@10, we’ll hear the one hit wonder from a group of session players that found themselves with a hit, so they had to become a temporary band, the classic song that a soul legend decided not to release until it became a hit for someone else … and the classic song that was written, recorded and released within a period of ten days, making it one of the fastest-released songs in pop music history.
Tell a friend … spread the word … and get involved. Use the comment section below to share your thoughts, send us birthday requests, and vote for BEST OF SET.
If you want to keep the songs a mystery, we’ve got you covered! But if you want to peek at the list, highlight the text below.
1. John Lennon – Instant Karma
2. Shocking Blue – Venus
3. Simon and Garfunkel – Cecilia
4. Edison Lighthouse – Love Grows (Where My Rosemary Goes)
5. Aretha Franklin – Son Of A Preacher Man
6. James Taylor – Fire And Rain
7. Freda Payne – Band Of Gold
8. Temptations – Ball Of Confusion (That’s What The World Is Today)
9. Three Dog Night – Mama Told Me (Not To Come)
10. Cold Blood – You Got Me Hummin’
BONUS: George Harrison – Isn’t It A Pity
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Feast your compound eyes on this: an exclusive look at an Ant-Man image that Marvel Studios will be sharing this weekend at Comic-Con.
Tag: EW Exclusive (71-80 of 747)
Last week we brought you the first exclusive image of Norman Reedus and Djimon Hounsou from the upcoming film AIR (which is directed by Christian Cantamessa and produced by The Walking Dead’s Robert Kirkman). And then we told you how Norman Reedus broke his toe during filming with an “unmanly move.” Now Reedus Nation will once again be in a frenzy as we present another exclusive image from the upcoming film featuring The Walking Dead favorite. In the photo, we see Reedus as Bauer, one of the two workers (along with Hounsou’s Cartwright) whose job is to maintain an underground bunker filled with sleep tanks set up to preserve the human race after the air outside has been rendered toxic. Naturally, complications arise. Reedus shared his thoughts on the film with us already, and now Robert Kirkman tells us how the movie came together and what to expect when it hits the big screen in the spring of 2015. (Also, make sure to click on the Full Size magnifying glass tab to see a larger high-res version of the photo.)
ENTERTAINMENT WEEKLY: So, you’ve conquered TV, comics, and now movies…
ROBERT KIRKMAN: I don’t know if conquered is the right word. I like all forms of entertainment, I hope to get into musical theater later. READ FULL STORY
A few years back, shortly before the release of his debut horror film The Pact, writer-director Nicholas McCarthy told EW, “I think hearing people scream is almost too addictive of a moment for me—I want to do it one more time.” Now, McCarthy is doing it one more time with At the Devil’s Door, another likely scream-inducing project which is released on VOD on August 8 and arrives in cinemas September 12.
With Comic-Con quickly approaching, Fox Home Entertainment wants to remind its fans about a little love story that they might have heard of. Yes, the one between The Fault in Our Stars‘ Augustus Waters and Hazel Grace Lancaster.
At Comic-Con, fans will have the opportunity to pre-order the film on Blu-ray, and EW has an exclusive look at one of the 300 limited edition TFIOS posters that will be paired with the pre-order. So for those of you attending Comic-Con, the posters will be available with the pre-sales at Fox booth #4229. Now go get your poster. Okay? Okay.
“Who’s Ultron?” This was what Captain America himself, Chris Evans, said at Comic-Con last year after finishing his Hall H Winter Soldier presentation and heading backstage to do some press.
He had missed the finale of the Marvel Studios showcase, which revealed the Avengers sequel would be subtitled “Age of Ultron,” with a plot centered on that fearsome artificial-intelligence whose robotic face looks like a grinning metallic vampire skull.
Given the studio’s intense devotion to secrecy, both he and Scarlett Johansson had no idea who they’d be battling the next time the Avengers reunited.
It’s okay to forgive them a moment of uncertainty. There are plenty of fans out there who have come to this fantasy universe through the movies, and not the comic books.
So here, finally, is the movie’s answer to that question: Who IS Ultron?
It might seem unfair to suggest the new horror movie Septic Man is going to stink, especially without having seen it—but the filmmakers probably won’t object on this occasion. Written by Tony Burgess (Pontypool) and directed by Jesse Thomas Cook (Monster Brawl) the movie stars Jason David Brown as a man who undergoes a hideous transformation after he is trapped in a septic tank.
They’re at it again. Walking Dead creator Robert Kirkman and star Norman Reedus are joining forces again for the movie AIR, which tells the story of two workers (played by Reedus and Djimon Hounsou) who are tasked with maintaining one of the underground bunkers set up to preserve the human race after the air outside has been rendered toxic. The bunkers are filled with sleeping tanks housing individuals seen as providing the best chance for rebuilding civilization.
AIR will be directed Christian Cantamessa and released in the spring of 2015, but we’ve got your exclusive first image from the film right here. In it, we see Hounsou (as Cartwright) and Reedus (as Bauer), who have been awoken from their sleeping tanks for their two hour shift—which occurs every six months—in the decommissioned missile silo. We commissioned Norman Reedus to tell us more about the movie, so he called in from the set this past spring and did just that. (Click on the Full Size magnifying tab to see a bigger high-res version on the photo.) READ FULL STORY
Fans of Peter Jackson’s early, gory output should definitely check out the trailer for the forthcoming horror film Housebound—a film which has apparently received the stamp of approval from Sir Peter himself.
Written and directed by New Zealand filmmaker Gerard Johnstone, the film stars Morgana O’Reilly as a woman who is placed on home detention and has to live with her mother. Mom believes her house is haunted. Is she right? Find out on October 17, when the film arrives in theatres as well as on VOD and iTunes.
People with the name “Michael King” may well find themselves asking “Wait, what the Hell is going on now?” when the new horror film The Possession of Michael King is released in August. As it happens, that would be an entirely appropriate question to raise.
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A 19-year-old male asked:
how to get rid of blue balls?
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Pain Management 43 years experience
Sexual Relief: Some type of sexual release such as masturbation, sexual intercourse or eventually you will probably have an erotic dream with emission. Regardless, no harm will come either way.
4102 viewsReviewed >2 years ago
Pathology 44 years experience
Ejaculation: This happens when there's way too much fluid in your seminal vesicles compressing the nearby genitofemoral nerve and causing the referred pain. It results either from abstinence or from prolonged arousal without final satisfaction. Ejaculation -- which will be copious -- will bring about immediate relief and you owe it to yourself to make sure this happens. Best wishes.
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A 32-year-old member asked:
What are some tips to reduce or rid the occurrences of seizures, aside from taking the meds?
1 doctor answer • 2 doctors weighed in
Specializes in Pediatric Urology
Discuss neurosurgery: Do not stop taking your medications until advised by your neurologist/seizure specialist.. Ask your neurologist to discuss stereotactic evaluation at a neurosurgical center performing these tests as well as treatments. You may or may not be a candidate. Good luck.
5868 viewsReviewed >2 years ago
A 41-year-old member asked:
How do I get rid of my son'sclaustrophobia?
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Pediatrics 39 years experience
Therapy: You must be very patient and seek the help of a child psychiatrist and a therapist, avoid situations where he might feel uncomfortable or "closed in". Do not avoid the issue, but help him confront it with the help of professionals . Also make sure the adults around him do not project behaviors that the child will pick up on.
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A 26-year-old member asked:
How do I get rid of excessive blushing? I blush so often that I've begun to exclude myself from situations that require me to communicate with people .
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Internal Medicine 26 years experience
Excessive blushing: People normally blush when they get excited, angry or embarrassed. Blushing can be triggered by scpicy foods, alcohol or hot temperature. Excessive blushing, however, can be due to social anxiety or panic disorder. Or medical conditions such as carcinoid syndrome, rosacea, or systemic mastocytosis can cause blushing. If you know the triggers such as foods, avoid them. I suggest you see a doctor.
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A 24-year-old male asked:
Is there any other way to get rid of blue balls without ejaculating? Would any medication work? Could i just put ice packs?
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Urology 36 years experience
"Blue balls": The condition you describe is most often due to prolonged erection. The erect penis, although engorged with blood, actually has ver low blood flow in and out . This "ischemia" due to poor oxygen delivery to the penis tissue eventually causes severe penile pain which often is referred to the scrotum and testes. Ejaculation typically causes the erection to subside. Thus, blood flow improves.
5336 viewsAnswered >2 years ago
A 25-year-old male asked:
What is the treatment for "Blue balls syndrome"?. I want to get rid of this problem.
1 doctor answer • 5 doctors weighed in
Family Medicine 30 years experience
Blue Balls-Slang: Blue balls is a slang term for the condition of temporary fluid congestion (vasocongestion) in the testicles sometimes accompanied by testicular pain, caused by prolonged and unsatisfied sexual arousal in the human male. The treatment would be to relieve your "sexual Tension" through masturbation or sexual intercourse leading to climax.
3528 viewsReviewed Jun 23, 2018
Last updated Jun 23, 2018
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A growing trend in software construction advocates the encapsulation of software building blocks as features which better match the specification of requirements. Feature Oriented Programming (FOP) is the research domain that targets this trend. The authors argue that the state-of-the-art approaches to FOP are not satisfactory because they only provide top-down methodologies to FOP. They propose to specify features as sets of first-class change objects which can add, modify or remove building blocks to or from a software system. They present ChEOPS, a proof-of-concept implementation of this approach and use it to show how this enables bottom-up FOP.
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|Project by EPJartisan||posted 04-09-2010 09:14 PM||1819 views||3 times favorited||10 comments|
I can be quite absent minded.. and often leave my car lights on. My neighbor here at the studio has saved me many times by calling me when they were on.. and giving me a jump the times my battery was dead. After the tragic death of his little nephew only a few months before a new nephew (the child’s brother) was born. After seeing my first Adirondack Chair.. he asked if I could make him a simple chair with the new baby’s initials and birth date… well I poured myself into making this piece for him. Like a broken record… I can’t do simple.
Also this is what my brand new 10” opening bandsaw can do. :)
-- " 'Truth' is like a beautiful flower, unique to each plant and to the season it blossoms ... 'Fact' is the root and leaf, allowing the plant grow and bloom again."


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Flevoland is a province of the Netherlands. Located in the centre of the country, at the location of the former Zuiderzee, the province was established on January 1, 1986; the twelfth province of the country, with Lelystad as its capital. The province has approximately 394.758 inhabitants and consists of 6 municipalities. After a flood in 1916, it was decided that the Zuiderzee, an inland sea within the Netherlands, would be enclosed and reclaimed: the Zuiderzee Works started. In 1932, the Afsluitdijk was completed, which closed off the sea completely.
The first part of the new lake that was reclaimed was the Noordoostpolder (Northeast polder). This new land included the former islands of Urk and Schokland and it was included in the province of Overijssel. After this, other parts were reclaimed: the Southeastern part in 1957 and the Southwestern part in 1968. There was an important change in these post-war projects from the earlier Noordoostpolder reclamation: a narrow body of water was preserved along the old coast to stabilise the water table and to prevent coastal towns from losing their access to the sea. Thus Flevopolder became an artificial island joined to the mainland by bridges.
The municipalities on the three parts voted to become a separate province, which happened in 1986. At Flevoland there is a large mediumwave broadcasting facility called Mediumwave transmitter Flevoland. Flevoland was named after Lacus Flevo, a name recorded in Roman sources for a large inland lake at the southern end of the later-formed Zuiderzee. Draining the Flevoland polders found many wrecks of aircraft that crashed into the IJsselmeer during World War II, and also fossils of Pleistocene mammals.

domain: history


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I love me a good Waldorf salad, but find all the mayonnaise in the dressing to be too heavy and rich for me. I came up with this healthy twist on the Waldorf that is lighter, but full of flavor and crunch. It has a lot of fiber and is nutrient dense to boot. And for times when life is crazy, but you want to make a heathy lunch without the labor, I give you permission to use canned chicken and bagged shredded cabbage like I did last week!
They have both at Trader Joe’s. 🙂 But you could probably find it at any large supermarket. And at the end of the week, you’ll have all that leftover turkey that you will want to put to good use, so you could use that instead.
I always have my whipped cottage cheese at the ready, but if you don’t, you could use Greek yogurt instead. I didn’t have grapes on hand that are usually in a Waldorf, so I threw in some dried cranberries for some color and and extra layer of sweetness.
Wishing all you Americans a Happy Thanksgiving this week!
Lean Waldorf Salad
1 tablespoon mayonnaise
1/2 cup whipped cottage cheese or Greek yogurt
1 12.5 oz. can chicken breast, or 1 1/2 cups chopped cooked chicken or turkey
salt and pepper to taste
4 cups chopped cabbage
1 Fuji or Honey Crisp apple, chopped
1/4 cup chopped, toasted walnuts
handful of dried cranberries to taste
- Mix mayonnaise and whipped cottage cheese or Greek yogurt together in a medium sized bowl. Add chicken and salt and pepper and incorporate. Mix in cabbage, chopped apple, walnuts and dried cranberries.
- Serve over a bed of salad greens.
Makes about 4 servings.

domain: food


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New Hampshire Governor Chris Sununu is currently the strongest Republican challenger to incumbent Maggie Hassan for U.S. Senate in 2022. Sununu and Hassan are tied in a hypothetical matchup and former Senator Kelly Ayotte is also statistically tied with Hassan. Retired General Don Bolduc and political commentator Corey Lewandowski trail Hassan by double-digit margins. Sununu continues to enjoy high favorability ratings in the state, while Granite Staters are divided in their view of Hassan. Residents are also divided on Ayotte, Bolduc is largely unknown, and Lewandowski is largely unpopular in the state.
Granite State Poll
UNH Survey Center, "Sununu Strongest GOP Challenger for Senate in 2022 2/25/2021" (2021). All UNH Survey Center Polls. 639.

domain: politics


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Special Counsel Mueller has been heralded by the MSM as an impartial judge and jury in the Trump-Russia investigation.
But all is not as it seems.
Center for Security Policy President Frank Gaffney has told Breitbart News Daily that Robert Mueller has been compromised by establishment/DNC interests
Swamp rat Jeff Flake has been losing by up to 20% in polls for the next GOP Senate Primary in Arizona.
How to respond? Quit politics
The mainstream media will take any opportunity to prove its theory that Trump is a sadistic madman.
But in the absence of the President actually *doing* anything like an evil dictator would, petty and indignant lefties are down to turning stupid, trivial things into fake "scandals."
President Trump flatly contradicted the Congressional establishment this morning, tweeting that despite what some are proposing, 401K plans are safe.
“There will be NO change to your 401(k),” Trump wrote on Twitter. “This has always been a great and popular middle class tax break that works,
Former President Jimmy Carter has shocked the news media by defending Donald Trump, dismissing Russian influence on the election and slamming Democrat leaders.
Where to begin? In an interview with the New York Times, Carter made several statements that have turned the news media upside down
How much more evidence do we need before Hillary Clinton is locked up?
That's a serious question.
It seems like we have mounds of evidence of wrongdoing by Hillary Clinton and he team, not the least of which includes The Clinton Foundation.
My personal suspicion is that President
Former President George W. Bush gave a strange, pro-liberal speech this week in which "Dubya" took veiled shots at President Trump's America-first outlook.
Many "RINO"s and never-Trumpers were all-too happy to swallow Bush's speech. But not everyone. At least one powerful conservative voice isn't having it.
In a statement this afternoon, President Donald Trump announced the capture of the Islamic State’s capital Raqqa in Syria.
"I am pleased to announce that the Syrian Democratic Forces, our partners in the fight against ISIS in Syria, have successfully recaptured Raqqah – the terrorist group’s
Will we finally get to know the truth?
It looks like it.
Thanks to President Donald J. Trump we will soon know the truth about what the government has kept concealed for decades. That is, if Clinton and Obama didn't already scrub the files.
Here was the announcement
When General John Kelly defended President Trump's phone calls to Gold Star families, he used the term "empty barrel" to describe Representative Frederica Wilson's loud talk that says nothing.
Now, Wilson and Democratic crony Joy Reid, among others, are calling the term "empty barrel" racist!


ATHLETES - THE OTHER SIDE
We often forget that the modern-day sportsman is so much more than an athlete. Athletes have other lives - often many other career chapters away from the sporting field. To be an athlete is just one part of who they are. In athletes: The Other Side, host and former head of Media Relations for the World Anti-Doping Agency, Ben Nichols explores the lives and achievements of athletes away from sports.


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"Vermont Dems pushing for extreme gender-neutral bathroom bill." 3. He said: "Supporters of the bill say transforming gender-specific single-stall bathrooms into gender-neutral facilities would cost very little money and provide all of Vermont's citizens and visitors with access to safe bathrooms." 3. NBC news covered the hearing:
In another progressive victory in a New England state, Vermont Gov. Phil Scott has signed into law a bill mandating that all single-user public restrooms in the state be marked as gender-neutral.
A bathroom bill is the common name for legislation or a statute that defines access to public toilets by gender (restrooms)—or transgender individual.Bathroom bills affect access to sex-segregated public facilities for an individual based on a determination of their sex as defined in some specific way—such as their sex as assigned at birth, their sex as listed on their birth certificate
NCSL tracks the latest state legislative activity relating to bathroom bills.This page has information on all states that have introduced bathroom bill legislation, as well as an overview of recent federal action, including: the May 2016 "Dear Colleague Letter from the U.S. Department of Education (ED) and the U.S. Department of Justice (DOJ).
"Vermont has a well-earned reputation for embracing equality and being inclusive," Scott said as he signed the bill into law at the Vermont Statehouse in Montpelier. "Two years ago, when I was running for governor, I was asked in a debate whether I would support gender neutral bathrooms in public places or not," Scott said.
Forcing transgender people to use private or separate bathrooms is not the solution. Offering separate or private bathrooms is a great way to ensure anyone can feel comfortable when they go to the bathroom, whether or not they're transgender. However, private bathrooms may be unavailable or very inconvenient to access.


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NBC Evening News for Tuesday, May 10, 1983
View other clips in this broadcast →
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(Studio) Report introduced
REPORTER: Roger Mudd
(DC) Banking industry's promotion of loans due to loose money examined; radio commercial heard. [Suburban Bank spokesperson Warren ROTHE - notes influx of large amount of money.] Impact on banking industry of right to offer money market funds outlined on screen, discussed. [Bank of America spokesperson William HENLE - wants to put deposits to work.] Banks' need to loan money explained. [HENLE - notes continuing conservatism of consumers.] Mona DeGraffenreid's experience with bank cited as example
REPORTER: Irving R. Levine
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Weather radar is an excellent tool for detecting precipitation, it can also detect other things such as insects and animals, just to name a few.
Such was the case last Wednesday when the radar in the Midwest picked up several areas of bugs.
The areas in blue are actually bugs.
Things appearing on the radar that is not precipitation is referred to as ground clutter.
Ground clutter is a common reference that will be made when examining weather radar. Things such as animals, dirt, and buildings are considered ground clutter.


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Perfect for the raucous sound of indie music, the Bullet Mustang HH is just plain fun to play. Powered by a pair of giant-sounding humbucking pickups, it sports a comfortable "C"-shaped neck with a modern 12"-radius fingerboard and a modern six-saddle hardtail bridge. A tonal powerhouse that punches well above its weight, the Bullet Mustang HH is the ideal instrument to power your next hit.
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Dual humbucking pickups
Three-way toggle pickup switch
Six-saddle hardtail bridge
Sealed die-cast tuning machines
The new FA-115 pack offers great Fender sound and tremendous value to anyone looking to...
A perfect choice for beginners, the new Squier® Strat® Pack has everything you need to...


Former Strictly Come Dancing professional Ola Jordan has slammed the BBC for sending Melvin Odoom home at the weekend.
She said it was "completely unfair" that he left the competition without facing a dance-off, as Anastacia - who was also in the bottom two - was unable to perform due to an injury.
When breast cancer survivor Anastacia had to pull out due to a tear to scar tissue from her double mastectomy, Melvin and his professional partner Janette Manrara became the first pair to leave the show as Strictly rules say the couple with the fewest viewer votes get sent home.
Ola, who left the show after 10 years in 2015, said: "I have never heard of a rule book. It's not fair. The BBC is all about fairness but they are not being fair."
She added that she thought that due to the circumstances, both Melvin, 36, and Anastacia, 48, should have remained in the competition for another week.
"The reason the judges have the last say on the dance-off is because they want a better dancer to go through. If they couldn't have done a dance-off then they should have put two couples through and done a double elimination next week.
"To give Melvin another chance. Melvin wasn't given the chance to dance. I felt sorry for him," she added.
"If the BBC is all about fairness then be fair. Anastacia went through a horrible time but Strictly is full on. That's just the way it is."
Melvin has told of his disappointment at being eliminated without the opportunity to perform to keep his place.
He had been set to face Anastacia in the dance-off and said he wanted to perform as if it was "the last dance ever".
Speaking on BBC Two spin-off show It Takes Two, Melvin told host Zoe Ball: "Do you know what, it was so funny because when we found out we were in the bottom two, Janette was like, 'Right Melvin, start stretching, we're going on soon'."
He added: "We wanted to go out there and just dance like it was the last dance ever in life. So yeah, but we can still do it."
It is the first time the dance-off has been called off during the opening rounds and some fans on Twitter were unimpressed with the rule that saw the former Xtra Factor host eliminated.


Last Wednesday, early in the morning, doorbell cameras in Anchorage, Alaska captured more than just the quiet streets of the sleeping town. They caught a giant meteor zooming across the sky, a sight we definitely don’t see every day. It was so bright that it lit up the whole sky for a few seconds, before burning out and seemingly disappearing behind the trees. [Read More…]
UK photographer takes a nap during the shoot, finds northern light photos on his camera
You have to be pretty lucky to capture the northern lights in the UK. But how lucky do you have to be to take a nap and wake up to images of aurora borealis on your camera? Believe it or not, this is exactly what happened to Chris Lowther from the UK.
Chris set everything up to take some photos of star trails during the night. He set a timer and took a nap, considering that it was late at night. When he checked the shots, a wonderful surprise was waiting for him: there weren’t only the stars, but his camera also captured the rare northern lights!
Feast your eyes on the epic top photos of 2022 Milky Way Photographer of the Year
When you move away from the city’s light pollution, a whole new world is waiting to be photographed. One of the most popular subjects is certainly our galaxy, and as far as I’m concerned, its sight will never cease to amaze me.
So, I was thrilled to learn that the travel photography blog Capture the Atlas ran another competition for the best Milky Way photo of the year. The results have just been published, and it seems that the top images get better and better every year. Dan Zafra of Capture the Atlas shared some of the winning photos with us, so let us feast our eyes together on these fantastic images.
Light pollution is ruining your photos, follow these three tips to minimize it
If you live in a city, photographing night skies is a challenge, to say the least. Light pollution affects our photos and makes the sky suck, coming from the ground and even from the sky. Even though we can’t lower light pollution on a global level, at least we can do something to minimize its impact in our photos. In this video from B&H, astrophotographer Jess Santos will tell you how.
Jess helps you get past light pollution and raise your night sky photos to a higher level. But she also shares some important facts about light pollution that affect more than just our photos.
Photographer captures once-in-a-lifetime shot of Comet Neowise, the aurora borealis, and Milky Way
The Canadian Rockies have always offered breathtaking sights, but take this dramatic mountain setting and pair it with a rare comet that won’t be visible for another 6,800 years and you’ve got the recipe for an awe-inspiring photo opportunity – one that photographers only dream of.
For an Australian mechanical engineer turned award-winning travel and landscape photographer, this dream became a reality in July 2020.
2021 Northern Lights Photographer of the Year winners reveal the otherworldly beauty of Aurorae
I’m pretty sure that capturing the Northern lights is on every landscape photographer’s bucket list. Well, it sure is on mine. If you’re looking for inspiration and a reason to finally travel and see the Aurora Borealis in person, the travel photography blog Capture the Atlas has a real treat! The winners of the annual Northern Lights Photographer of the Year contest have just been announced, and we share the top images with you.
Perseid meteor shower peak starts tomorrow, don’t miss it
The day some of us have anxiously been waiting for is just around the corner. Starting tomorrow, the Perseid meteor shower is about to reach its peak. With up to 100 meteors every hour, it’s the most spectacular meteor shower of the year. But we don’t have too much time to observe it, so get prepared as soon as possible.
Photographers, get ready for the Perseids, the most spectacular meteor shower of the year
While there are dozen of meteor showers every year, the Perseids is the best one. And it’s right around the corner, peaking mid-August with up to 100 meteors per hour. So, if you’re up for some night sky photography, now is the right time to get ready to shoot this spectacular sight.
Here is how I took this photo of the Milky Way over the Temple of Apollo
The first thing I always say to the participants of my workshops is to always spend enough time in preparation. I strongly believe that in order to make a good photo, no matter the genre, you have to be prepared as best as you can.
Preparation for astrophotography, at least for me, means not only finding the “ideal” location, checking the weather conditions, setting the gear, etc, but most importantly, to envision the image you want to make before even leaving your home. How the elements will be arranged and set on the frame. In astrophotography, as we are mostly working on difficult, dark conditions, it is not ideal to start searching for possible points of interest and framing scenarios during the night.
This is why my all-time favorite tools when envisioning a photo or an even bigger project are these: a pencil and a notebook.
These are the top ten stunning photos of the 2021 Milky Way Photographer of the Year
The Milky Way season is in full swing, and we’re slowly coming back to normal and traveling again in order to take photos. So, shall we celebrate with a set of stunning Milky Way photos? Wait, don’t answer that – of course we shall!
Capture the Atlas has selected the top ten images of the Milky Way taken all over the world. If you are planning an astrophotography trip soon, these will kickstart your inspiration. But even if you are staying home, you’ll still enjoy these photos and their otherworldly beauty.
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The old deed books within the office of the St. Johns County Clerk of the Circuit Court and Comptroller contain documents about the rich heritage of the African American community of St. Johns County. In commemoration of Black History Month, St. Johns County Clerk of the Circuit Court and Comptroller has published a virtual exhibit to showcase Black History.
Documents recorded by the clerk’s office show free Blacks purchased, sold, and mortgaged property. In other record books, it shows enslaved Blacks were bought, sold and mortgaged. The record books also contain manumission documents, which were legal documents that freed those enslaved.
When Florida became a United States territory in 1821, the District of East Florida encompassed the entire peninsula. All official recordings were done by the clerk’s office in St. Augustine. Documents pertaining to the Florida Keys, the Indian River, and Tampa Bay areas were all recorded by the clerk’s office in St. Augustine. In those early territorial days, the Seminoles were still conducting business on their own before restrictions were put in place by the U.S. Government. This exhibit will feature a few personal transactions by the Seminoles.
Residents brought their original documents to the clerk’s office to be recorded. Clerks transcribed the information verbatim into record books and returned the original document to its owner. The county’s deed books are composed of these official copies. Some people waited many years before bringing their documents to be entered into the clerk’s official records.

domain: library


text:
(MENAFN- The Peninsula)
#qatar 2022 The Peninsula
Doha: The Prime Minister of the United Kingdom, Rishi Sunak, has praised Qatar for the great successes so far recorded at the FIFA World Cup Qatar 2022.
In a tweet via his verified Twitter handle on Sunday night, the UK premier said: 'Hats off to Qatar for hosting an incredible World Cup so far. The group stages will be remembered as one of the all-time greats.'
On Friday, the Amir, HH Sheikh Tamim bin Hamad Al Thani, spoke by phone with the UK Prime Minister.
During the call, Sunak congratulated the Amir on the launch of the FIFA World Cup Qatar 2022, praising the good organisation, and wishing the participating teams well in the competition.
The call dealt with discussing bilateral relations and the means to enhance them in all different fields of joint cooperation, in addition to discussing the latest regional and international developments.
MENAFN provides the information “as is” without warranty of any kind. We do not accept any responsibility or liability for the accuracy, content, images, videos, licenses, completeness, legality, or reliability of the information contained in this article. If you have any complaints or copyright issues related to this article, kindly contact the provider above.

domain: sports


text: The advance of replication forks to duplicate chromosomes in dividing cells requires the disassembly of nucleosomes prior to the fork and the rapid assembly of parental and de novo histones in the newly synthesized strands behind the fork. cells . Importantly, the histone dimer H3-H4 that bridges Asf1 with Mcm2-7 is definitely specifically revised with parental marks (H4K16Ac and H3K9me3) under hydroxyurea (HU) conditions that enable build up of replication forks, suggesting that Mcm2-H3-H4-Asf1 can be an intermediate in the process of parental SJN 2511 enzyme inhibitor histone assembly . Interestingly, Asf1 binding to (H3-H4)2 splits the tetramer in vitro and binds to the dimer in a way that occludes the H3-H4 tetramerization interface [59,60], and accordingly, a crystal structure of a ternary complex with Asf1, Mcm2 and a dimer of H3-H4 has been solved [45,46]. These results raise the probability that, under certain conditions, the parental (H3-H4)2 tetramer is definitely transiently break up during its transfer . Depletion of human being Asf1 affects DNA unwinding at replication sites and prospects to a reduction in the amount of ssDNA in the fork, and a similar phenotype can be acquired by impairing Asf1 function through histone overexpression . These outcomes claim that Asf1 might facilitate DNA unwinding on the fork through its capability to transfer histones during chromatin set up. Appropriately, Asf1 depletion causes cell routine arrest in take a flight, chicken and individual cells [56,58,62]. Intriguingly, a V94R Asf1 mutant, which does not have (H3-H4)2 splitting activity and cannot type Asf1-H3-H4-Mcm2-7 complexes [58,63], enhances instead of lowers DNA synthesis within a cell-free program of egg ingredients . Asf1 might therefore play a far more organic function in the fine-tuning legislation of replication fork development. 5. Systems of New Histone Set up Furthermore to recycled parental histones, chromatin SJN 2511 enzyme inhibitor set up on the fork requires the deposition of synthesized histones newly. Appearance of canonical histones is normally activated in past due G1/early S stage to ensure an instant way to obtain histones during replication, which is repressed in early G1, G2, and mitosis to avoid the deleterious implications of the unscheduled more than histones for DNA fat burning capacity [64,65]. Appropriately, mutations and inhibitors that impair DNA synthesis cause several SJN 2511 enzyme inhibitor systems that repress brand-new histone synthesis and buffer from an excessive amount of histones [66,67]. Recently synthesized histones are chaperoned in the cytoplasm towards the nucleus and improved post-translationally to facilitate their transfer towards the chromatin set up elements in the replication fork (Shape 1). Specifically, acetylation from the amino terminal tails of H3 and H4 takes on redundant tasks in chromatin set up . Acetylation of lysines 5 and 12 in histone H4 from the acetyltransferase Hat1 can be conserved from candida to human beings [69,70], as the acetylation design from the amino terminal tail of H3 can be much less conserved. In budding candida, lysines 9 and 27 will be the primary targets and so are acetylated from the acetyltransferases Rtt109 and Gcn5 [71,72], whereas a small fraction of mammalian H3 can be acetylated at lysines 14 and 18 . Similarly very important to replication-coupled chromatin set up SJN 2511 enzyme inhibitor in yeast may be the acetylation of H4K91 by Hat1  and of H3K56 by Rtt109 [74,75,76,77]. Certainly, almost all recently synthesized histones H3 can be acetylated at lysine 56 SJN 2511 enzyme inhibitor in candida . On the other hand, in human beings this modification exists in under 1.5% of histone H3, and represents such as for example H3.1K9 monomethylation by SETDB1 characterize synthesized histones . The contribution of yeast H3K56 acetylation towards the deposition of synthesized histones continues to be extensively researched recently. The chaperone Asf1 takes on an instrumental part in this technique by binding recently synthesized H3-H4 dimers and showing these to Rtt109 for acetylation [54,77,78,79,80]. H3K56 acetylation Rabbit polyclonal to ACVR2A escalates the binding affinity from the dimer H3-H4 for the histone deposition elements CAF1 and Rtt106, as well as the binding of CAF1 to chromatin . This technique can be facilitated from the Rtt101Mms1/22 complicated (shaped by Rtt101 as well as the putative adaptor proteins Mms1 and Mms22) or its human being ortholog Cul4DDB1 . Rtt101Mms1/22, which affiliates using the replication development complicated during S stage , binds and ubiquitinates fresh histone H3 acetylated at lysine 56. This modification weakens Asf1-H3-H4 facilitates and interactions H3-H4 transfer to downstream chromatin assembly factors including Rtt106 . It’s important to notice that the.


Jennifer Lopez was all smiles during a gym break to show fans how she stays hydrated.
The dancer posed in a workout studio against a mirrored wall after a recent session Thursday.
J.Lo showed off her post-workout glow in a tiny white crop top that revealed her toned stomach. She paired the tight tank with baggy brown sweatpants and wore big hoops to accessorize the sporty look.
The actress shared two photos of the look. She wore her long hair in a middle part down her back. J.Lo wore matching white sneakers and had manicured tan nails for the shot.
She was all smiles in the second picture. The famous singer had on black headphones, possibly listening to a workout playlist that fans can only hope includes Jenny from the Block on it.
She also sported a sweat towel from the brand Body Armor around her neck.
Jennifer Lopez stays hydrated in a crop top
J.Lo shared with her 224 million followers how she stays hydrated during her gym sessions.
The post was in partnership with BODYARMOR, a popular sports drink that comes in a variety of flavors. It is made with coconut water and offers low-calorie versions of some flavors.
The singer declared herself #TeamBODYARMOR. Jennifer’s flavor of choice is BODYARMOR’s Peach Mango Lyte variety which has no added sugar.
Whether it’s the drink or the workout or both, whatever J.Lo is doing in the gym is certainly working.
She has stunned in plenty of looks lately that show off her amazing abs, including other workout crop tops.
The mom of two was recently spotted stepping off a plane looking pretty in pink. She wore a cropped pink hoodie and matching sweatpants that complimented her physique.
J.Lo adds author to list of accomplishments
The model, actress, and singer has now added author to her list of achievements as well.
Jennifer Lopez announced this week that she co-authored a children’s book with late-night talk show host Jimmy Fallon.
The bilingual English and Spanish book called Con Pollo is out in bookstores now.
Jennifer has two kids with her former partner, Marc Anthony. The couple’s twins are 14 years old now.
J.Lo’s child, Emme (they/them), seems to be following in their mom’s performer footsteps.
Emme delighted fans by singing alongside their mom at her Superbowl performance in 2020. The mother-daughter duo has since performed other duets and shows no signs of stopping.More: Jennifer Lopez


Apparently some cyclists are spooked by explosions. This story has nothing to do with me, except that I recall a man photographing us from the roadside. The other rider is a Kiwi whom I had met moments ago. We were both travelling downhill, downwind at a rapid rate.
This article was “front page” on the Global News Calgary website: