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Twelve Phases of Human Experience
CAPRICORN - Page 1 of 3
The time of the winter solstice has now come, opening the Gates of Capricorn. The days have decreased in length as much as they ever will. Long winters nights absorb nature in their repose, as snow covers the ultimate disintegration of living things with its vast expanse of peace and quietude. Death seems to rule supreme over the visible universe. And yet, somewhere and forever, a new Christ is born. Life surges once more with the Sun from its southern decline. The Sun moves northward, its daily arc of light becomes slowly tauter and more radiant. The promise of spring spreads like a mystic fire over the earth to tell "men of good will" that the New Life has begun to win over arrested death.
What is this new life which men have symbolized in the beautiful Christ-story, whose roots go deeply into the soil of older mythologies? Who is the eternal Christos, whose significance remains everlastingly true and vital, whether or not men believe in the historical or religious Christ? It is the "Day-force"; that aspect of the bi-polar life-force which, as a personalizing energy, tends to transform the scattered and disintegrated remains of a previous cycle into a new organic whole, integral because defined by limitations, creative because conscious. That new organic whole in the realm of mankind is what will grow in time into the fulfilled personality: that is, the human individual, conscious of his relative uniqueness, centered in the sense of his "I-am-ness," in an ego. The Christos is that power in the universe which leads men to "individuation." It is the foundation upon which all concepts of equality and democracy, of the abstract value of the individual, of the dignity and intangibility of the human personality, are based. It is the foundation of the "self-evident truths" of the Declaration of Independence, the center of the "Rights of Man."
The Christos is the universal energy of the Day-force during its period of ascendancy through winter and spring. It is "born" at the winter solstice, because, from that day onward, it increases at the expense of its polar opposite, the Night-force, which thenceforth begins to decline. The Night-force is an in-gathering, collectivizing energy. It expands personality into society through the magic of human relationships. It begins with the building of the family, at the symbolical summer solstice, in Cancer, the sign of the home. It extends progressively the sphere of this family through the zodiacal phases of Virgo and Libra. It glorifies man's responsibility to his progeny and man's participation in all social groups. It impels the individual to seek an ever deeper identification with ever larger collectivities. It brings to man the generalizations and the discoveries of civilization, whose development binds together generation to generation, racial group to racial group, individual achievement to individual achievement — until personalities discover themselves to be but relatively insignificant cells in the vast organism of human society. Tribal groups and small nations ultimately disappear. The days of the empire have come. The State rules supreme; and its symbol of power, Caesar, multiplies itself in effigy through the ubiquitous and all-corrupting power of money.
Caesar and the Christos: both of them operate through the zodiacal field of Capricorn. Caesar is at the apex of his power; Christ is only a hunted baby. Yet Caesar's empire will soon collapse and the power of the Christos will wax ever stronger through Aquarius and Pisces, until it arises as an irresistible challenge of life and personality with the coming of spring and the ascendancy of the Day-force in Aries.
In Capricorn, the individual power of the human personality is seeking its way out, struggling from under the great weight of the State. The Night-force triumphs. Society is seen as an ultimate in that vast collective organism, the State, which dominates even its leaders. The great flights of civilization soaring through Sagittarius on the wings of the philosophical, scientific and social mind have now reached a point of crystallization. Perceivers of the beyond are superseded by organizers of empire. Ever shifting and remote boundaries must be watched and fortified by armies and administrators. The central authority must establish rigid patterns of government so as to hold under its impersonal rule many and diverse races, many trends of thought, many traditions.
The imperial Rome of the Caesars is no longer the original citadel of Roman citizens, the sturdy and vigorous Rome of earlier days. It is a sprawling metropolis, a universal city. Likewise, when a man has passed successfully through the evolutionary periods represented by Scorpio and Sagittarius, he is no longer the direct and aggressive ego hiding his social uncertainties under big dramatic gestures. The ego has expanded by becoming established in social groups, through partnerships of all kinds, through identification with the strange and wondrous powers which rise from all collectivities, from their ancient past, from that reservoir of unfathomable energy which has been called the Collective Unconscious.
This Collective Unconscious, time after time, has flooded the merely personal ego with intoxicating powers released by non-procreative sex and by civilization. Either the human person has become the tool of such powers, passively submitting to lust and the hectic rhythm of city-life; or else he has mastered these powers. He has become adept in Scorpio and philosopher in Sagittarius. His ego, then, instead of expanding into a power-greedy monstrosity ceaselessly avid for more lust, or more knowledge, or more money, has undergone a basic metamorpbosis. It has surrendered its energy to a greater center of organization and of consciousness, which is the Self — the center of both the conscious sphere and the vast Unconscious around it.
By permission of Leyla Rudhyar Hill
Copyright © 1943 by David McKay Company
and Copyright © 1970 by Dane Rudhyar
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domain: literature


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Pence Wants Lawmakers To Empty Remaining Half Of Major Moves 2020 Fund
Governor Mike Pence says he wants the State Budget Committee to release the second half of the Major Moves 2020 fund.
Two years ago, lawmakers put $400 million into what they called the Major Moves 2020 fund. It was meant for long-term, future projects.
Pence last year secured the release of half of the fund to add lanes to major interstates. The governor Tuesday announced he will ask the State Budget Committee to approve the transfer of the remaining $200 million. He says it will be used for capacity building.
“You know, I always say to people, ‘If you’re going to be the crossroads of America, you better have the roads to back it up,’" Pence says. "And the Major Moves 2020 fund was established to strengthen the capacity, particularly adding additional lanes.”
State Budget Committee Chair Luke Kenley (R-Noblesville) says Pence’s plan is in line with what he wanted the money to be used for.
“So that we could, for example, have six lanes on I-70 and I-65," Kenley says. "So I think he’s making a good investment and I’m okay with it.”
The State Budget Committee meets Thursday.

domain: news


I was covering TVs the time CES: for years, so it takes a lot to surprise me. I’ve seen some wild screens like that to wrapand they are so big mostly video walls, but they usually come after several rounds of prototyping, which blunts the shock. When I walked into LG’s room at a Las Vegas hotel, what I saw across the room came big surprise.
And I mean big. It is a 97-inch OLED TV and remains the largest OLED TV in the world. And since OLED delivers the best picture quality available, it’s pretty damn impressive in person at that size. But it was no surprise… LG introduced it last year. The jaw drop for me came when the LG rep told me beautiful, massive 4K: the image was broadcast wirelessly to the TV.
Wireless TV is real, and it’s coming this year.
Read more: It the biggest tech trends we saw at CES. Also, here it is CES highlights till now.
Across the room from the TV sat a wireless transmitter box. On the back of the box were standard HDMI: plugs and a few other connections, and one HDMI cable ran to the Blu-ray player. The image on the screen was from a Blu-ray disc sent wirelessly – and flawlessly, to my eye – from the box to the TV. The top of the box can be rotated to point the internal antenna at the TV.
The TV itself had no video inputs at all, just bare metal where TV inputs are normally found on the back. The idea is to cut down on wires, the age-old bane of a beautiful TV set-up. You, the person who can afford a 97-inch OLED TV, keep your AV gear inside the closet out of sight, along with the transmitter box that everything connects into. All that’s left of the TV is the power cord, which LG has cleverly hidden inside one of the legs of the stand.
Of course, any number of TV stands can also hold your gear. But the wireless connection allows the TV to stand alone, which looks impressive on one of LG’s easel stands (pictured above) and can greatly simplify wall mounting.
LG says the box can be located up to 30 feet away from the TV. I asked if the wireless connection was a potential risk, especially if you’re sitting between the box and the TV, and company representatives told me it wasn’t because it uses the same technology as standard Wi-Fi routers. They also said it won’t affect other Wi-Fi traffic. Signal can set up to 4K, 120 Hz resolution, which is pretty much the maximum for today’s games. It’s also the highest resolution and frame rate most TVs can handle, including LG’s regular 4K OLED models.
The box has three HDMI inputs, which is surprising since most high-end TVs have four, but it doesn’t hurt in my book. The rest of the ports are typical of a TV: antenna, two USB, Ethernet and optical digital output, as well as a serial port for home automation control.
Wireless TVs have been sold in the past, and wireless technology has also found its way into projectors. You can also buy wireless HDMI extenders for $100 or less, but they typically can’t handle that much bandwidth. This is the first time I’ve seen it built into a TV in years. A company called Displace TV also showed off a wireless OLED model at CES, but it’s a 55-inch battery-powered display designed for portability.
In addition to the 97-inch size, LG will release its wireless OLED, called the M3 series, in 83-inch and 77-inch sizes. LG says it will arrive in 2023, and pricing, like the rest of LG’s 2023 TVs, is still to be determined. For reference, LG charges $25,000 for its standard, wired 97-inch OLED TV and $2,900 for its 77-inch TV, so regardless of size, the M3 won’t come cheap.
In addition to the M3, LG was also introduced Three other series of cable OLED TVs at CES 2023.
This product was selected as one of the best products of CES 2023. See other Best of CES 2023 award winners.


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Finally, number four of the four illustrations I created for the Words to Live By exhibition ‘Get Home In Time For Tea’. The sentiment here being that after your day of adventuring, it’s important to wend your way back to your cosy Hobbit hole or campfire to enjoy a hot brew…and that it will taste all the more delicious after the fresh air and fun you’ve enjoyed on your escapades to the mountains, sea and forest.
It’s a concept I’d like to play around a bit more with in future illustrations. I really love the connection between nature and the outdoors and how it feels when you settle down to a cup of tea after being outside. Or indeed having a tea whilst out in nature. The comfort from the warmth of the cup and how it restores and revives you. Biscuits or cake to be included in this ritual whenever possible of course.
In the next post I’ll share the final, framed piece and a few snaps from the show itself before we move on to talk about some other things. In the meantime, get that kettle on! 🙂
Here’s the second of four illustrations that I created for our Drawn Chorus exhibition ‘Words to Live By’. Swimming in the sea is something that I will definitely be doing a lot of this Spring and Summer now that I’m living back by the coast. Though I will be waiting until the average water temperature gets just that bit warmer… I’m a fair weather swimmer, that’s just how it is! I’ve a huge amount of respect for the brave souls I see venturing in at this time of year though. It’s such a lovely thing to see so many happy people bobbing up and down in the water, even in icy January.
I used watercolours, conte crayons and 8B pencil for this piece. I imagined that the bather is the same figure from the previous ‘Visit the Mountains’ illustration, hence the same red hat and boots that are stashed on the nearby rocks while they relax in the water.
I’m very excited to to announce that I’ll be taking in part in the new Drawn Chorus Collective show ‘Words To Live By’! The show will feature the gorgeous work of a host of talented collective members plus our awesome guest artists. From illuminated wordplay to typographical personal mantras and gilded sign writing, the show will celebrate the combining of text and image across a wide range of mediums.
If you’re in London town between the 15th and 21st of November, do come along to the Espacio Gallery on Bethnal Green Road and say hello. There’s going to be a popup shop too, if you’re looking for a few Xmas treats. I’ll have some Owlstation Store goodies there at special show prices (come bag yourself a bargain!).
Aside from my excitement of actually being part of a real, physical, IRL show again…I’m just so looking forward to seeing some art for the first time in forever! The Private View will take place on Thursday 18th 6pm – 9pm, I’ll hope to see you there.

domain: hobby


text:
||Archival Material, Book
|All Authors / Contributors:
Dunning & Donaghe (New Haven, Conn.)
14 ALS from Dunning & Donaghe, a lumberyard company in New Haven, Connecticut to Thomas W. Smith & Co., proprietors of a lumber mill in Augusta, Maine. The letters, primarily lumber orders, reflect Dunning & Donaghe's concern with lumber quality and interest in the possibilities for hemlock boards. Bills of timber are given for the building of the new statehouse in New Haven (designed by Ithiel Town and opened in 1830), wharf logs needed by the (Farmington?) Canal Committee, as well as for an unidentified small church and three small dwellings.

domain: history


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Any suggestions for a good restaurant that will be open Xmas Eve and still actually have dinner reservations available for earlier than 10 pm despite booking at this late date?
Try Indigo I liked it alot when I went and it seems to never have reservation problems.
Thanks - I'll check it out - let you know
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domain: food


No gunsmithing required for increased accuracy and improved sight picture. Fully adjustable for elevation and windage. Easy to install. Replacement sight is held in place with a single, hardened steel roll pin. Available with open blade or removable, aperture rear sight for hunting or target shooting.
Big Book Catalog, Issue:73, Page:317
SPECS: Steel, blued, matte finish.


The Vivo V15 Pro is a mid-range smartphone with a sleek and slim bezel-less screen, a pop-up selfie camera, and a triple rear camera setup. The phone is one of the most stylish phones in this price segment. The device has a futuristic pop-up camera along with an excellent OLED notch less display. The devices cameras and battery life are also quite good.The phone has a triple rear camera setup which includes a 16MP primary sensor with an f/1.78 lens, an 8MP secondary sensor with a 120-degree super wide-angle f/2.2 lens, and a 2MP tertiary sensor which is meant specifically for bokeh effect with an f/2.4 lens. It has a 32MP selfie camera with f/2.0 lens which clicks wonderful and clear selfies.
DesignRead More ...
The V15 Pro comes with a 6.39-inch Super AMOLED screen with Full HD+ resolution. It has an in-display fingerprint sensor for added security. The phone has a screen resolution of 1080 x 2316 pixels, and has a pixel density of 404 ppi. It is available on Topaz Blue, Coral Red, and Ruby Red colours. The device measures 162.39 x 77.33 x 8.85mm and weighs just 201 grams.
The V15 Pro has a 32MP selfie camera which pops up from the top and takes bright and clear images. It has a triple rear camera setup with 48MP wide-angle camera, 8MP ultra-wide camera, and a 5MP depth-sensing camera. The phone’s camera features an LED flash, HDR, and panorama. The front 32 MP selfie camera can fully elevate in just .46 seconds. It has impressive beautification feature which clicks beautiful selfies. You can make your face look slimmer and skin smoother, as well as add different portrait lighting effects while clicking pictures. With the Vivo V15 Pro clicking perfect selfies is just a breeze. You also get your favourite photography features like AI Body Shaping to AI Portrait Lighting. The phones triple rear camera set up includes a 16MP primary sensor with an f/1.78 lens, an 8MP secondary sensor with a 120-degree super wide-angle f/2.2 lens, and a 2MP tertiary sensor with f/2.4 lens. The 32MP selfie camera with f/2.0 lens clicks picture perfect images.
It runs on Android 9 Pie OS out of the box with the company’s FunTouch OS on top. Under the hood, the phone has a Qualcomm Snapdragon 675 processor with 6GB RAM for faster processing. It has Adreno 612 graphics, which makes it easy to play games on the phone. It comes with Fingerprint (under display), accelerometer, gyro, proximity, and compass sensors. For gamers, the phone comes with a Game Mode 5.0. You can enjoy e-sports like a pro by entering Competition Mode, and use the Dual-Turbo mode to increase smooth gameplay. Powered with a with a powerful Qualcomm Snapdragon 675AIE processor users can chat, play games, watch videos, or switch between apps or surf the Internet. Paired with 6 GB of RAM users can enjoy a seamless multitasking experience.The device runs on Android 9 Pie-based FunTouch OS 9 that comes with a host of useful features which offers a seamless user experience.
Battery and Storage
The phone is backed by 3700mAh battery and comes with Dual Engine fast charging. The phone can charge to 24% power in just 15 minutes of charging. It has a microUSB 2.0 port. Connectivity options included in the phone are Bluetooth, USB, Wi-Fi, 4G, and GPS. It has 128GB internal storage that gives ample space for all your music, videos, etc.
Powered by the octa-core Qualcomm Snapdragon 675AIE processor and up to 6 GB of RAM users can enjoy a seamless multitasking experience. It has Adreno 616 GPU and up to 6GB RAM, which allows users to enjoy web browsing, gaming, media, etc.
Connectivity options includes 4G, Wi-Fi, Bluetooth v5.0, GPS/ A-GPS, USB 2.0 with OTG, and a 3.5mm headphone jack. It has an accelerometer, ambient light, fingerprint, magnetometer, and a proximity sensor.
Vivo V15 Pro Price In India Starts From Rs. 21099 The best price of Vivo V15 Pro is Rs. 21099 in Flipkart, which is 2% less than the cost of Vivo V15 Pro in Amazon Rs.21469.This Mobile Phones is expected to be available in 128GB variant(s).
|Flipkart||Vivo V15 Pro (Topaz Blue, 128 GB)(6 GB RAM)||₹ 21,099|
|Amazon||Vivo V15 Pro (Topaz Blue, 6GB RAM, 128GB Storage)||₹ 21,469|
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Six Million Americans Celebrate Kwanzaa — But Did You Miss it?
Did you celebrate Kwanzaa this year? According to the NPR, citing the National Retail Association, two per cent of Americans did so — six million of your friends and neighbors. But did you miss it altogether? A new bill proposed by a Pennsylvania Democrat might make sure that residents of her state, anyway, will be less likely to miss it in the future.
On January 10th, 2015, Representative Vanessa Lowery Brown (D-PA) proposed a bill which will designate the week of December 26th through January 1st, 2016, as “Kwanzaa Week” in Pennsylvania. This bill recognizes the cultural significance of the holiday for African people throughout the world.
What is Kwanzaa? Many people of many races in America still are not too sure, and can’t really define what the holiday is. Even fewer Americans, of whatever race, are aware of the holiday’s origins. According to The African American Lectionary, Kwanzaa was created by Dr. Maulana Karenga, a professor of Black Studies at California State, Long Beach, and an activist in the Black Nationalist Movement, fifty years ago — 1966, during the height of the civil rights movement in the US.
Kwanzaa is supposed to be celebrated for a week — from December 26 to January 1. Families who observer the holiday light the kinara — a candle holder — join in for a festive holiday meal, pour libations in honor of African history and ancestry, and give one another gifts. There are Seven Principles of Kwanzaa — ranging from “Umoja” (unity) to “Kujichagulia” or self-determination to “Kuumba” or creativity. As Dr. Karenga wrote, Kwanzaa should
“…give Blacks an alternative to the existing holiday(s) and […] an opportunity to celebrate themselves and their history, rather than simply imitate the practice of the dominant society.”
A holiday that is meant to create a mixture of American and African cultural traditions, the week-long holiday honors the past of Americans who descend from the African diaspora.
Representative Brown gave a rousing summary of Kwanzaa and its significance in the preamble to her Resolution:
“WHEREAS, Kwanzaa is an African-American holiday which celebrates family, community and culture and is observed each year by millions throughout the African community on all seven continents; and WHEREAS, The name Kwanzaa is derived from the phrase “matunda ya kwanza,” which means “first fruits of the harvest” in Swahili, a language that is the most widely spoken African language; and WHEREAS, Kwanzaa is a cultural holiday, not a religious holiday, and is open to all religious faiths from December 26 to January 1 each year; and WHEREAS, Kwanzaa is a profound expression of African people being committed to their cultural values and heritage, an annual reaffirmation of the bonds between them as a people and a celebration of their history […]”
Kwanzaa, though it started in America, is now also celebrated in Canada and in the Caribbean.
Many people would find Rep. Brown’s Resolution inspiring — as it demands recognition of something often overlooked, the African linguistic, economic, religious and cultural heritage of millions of Americans. Many would find it surprising that Kwanzaa is not a race-specific holiday — -Rep. Brown notes that it is open to anyone. And some might worry about the government having any resolutions or legislation at all about any religious, ethnic or racially focussed holidays, given the Church-State divide in our Constitution, and given the controversy that has attached itself to other religious or cultural observances in public space, such as Creche scenes on town hall lawns, or Sikh headwear in relation to the rules governing the uniforms of New York City police.
What do you think? Should we have a week dedicated to celebrating or raising awareness of Kwanzaa in Pennsylvania? If so, how about in all states? Or do you think that a State legislature should stay out of the area of making official designations about culturally-oriented or religiously-oriented observations?
Do you and your own family celebrate Kwanzaa? If so, how? Share your voice!
Use Daily Clout’s BillCam tool to read the full bill, to tell Representative Brown whether or not you support her bill, to contact your local representative about it, and to raise awareness by sharing this bill and your comments through social media, with your friends and social networks.
One of our country’s most important freedoms is that of free speech.
Agree with this essay? Disagree? Join the debate by writing to DailyClout HERE.


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The importance of washing your hands
Hand hygiene is a procedure known worldwide as the elimination of microorganisms through the use of soap and water, or hand sanitizer. This action has been used to counteract Health Care Associated Infections (HAI). Over the years, it has become clear that it is not just a procedure, it is a patient safety measure. Hands are the main germ transmission route during health care and the most important measure to avoid harmful germ transmission is to avoid Health Care Associated Infections (HAI).
October 15 is the date on which the World Health Organization (WHO) declared the World Hand Hygiene Day, aiming for this practice to become a habit in daily routines, whose main objective is to avoid spreading a number of diseases that mainly attack the digestive system, but that compromise other parts of the organism.
In order for everyone to carry out this procedure, hand hygiene became a safety indicator in health systems. It is integrated into essential actions for patient safety and international goal #5: reduction of infections associated with healthcare. As such, healthcare institutes are committed to fully carrying out the procedure.
At the Shriners Hospital, hand hygiene has become the main tool to prevent infections. Since the COVID-19 pandemic, the number of hand sanitizer dispensers has increased by 30%, which represents an increase in hand washing. You have sufficient material resources to carry out this practice and protect your patients against cross-infections. Furthermore, from the beginning of the pandemic, hand hygiene has been promoted to patients and employees within the hospital starting at screening, since everyone needs to complete the procedure to enter the hospital and we recommend the use of hand sanitizer at all times.
Even so, they continuously train their colleagues, twice a year, on how to perform hand hygiene and the advantages of performing the procedure. Emphasis is placed on the 5 moments, a strategy implemented by the WHO to avoid cross contamination and guarantee patient safety.
Shriners Hospital for Children Mexico shares 5 relevant points for hand washing:
- Washing your hands with water alone is not enough.
- Washing your hands with soap can avoid diseases that have killed millions of children every year.
- Critical times for handwashing with soap are after using the bathroom, or cleaning a child, and before handling food.
- Handwashing with soap is the most cost-effective health intervention.
- Children can be agents of change, being a more enthusiastic part of society.
Keep In Touch
Join our mailing list to stay up to date on everything that's happening at Shriners Children's.

domain: medical


Timing chain .005" shorter for line bored applications
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text:
Aspartic Acid, also known as aspartate, is an excitatory neurotransmitter in the brainstem and spinal cord. Aspartic acid is the excitatory counterpart to glycine, an inhibitory neurotransmitter. Low levels have been linked to feelings of fatigue and low mood, whereas high levels have been linked to seizures and anxiousness.
5 Alpha Reductase
An enzyme that converts testosterone, the male sex hormone, into the more potent dihydrotestosterone (DHT).
A putative health disorder in which the adrenal glands are claimed to be exhausted and unable to produce adequate quantities of hormones, primarily cortisol. Also called hypoadrenia and adrenal insufficiency.
Not aging or appearing to age.
Multidimensional process of physical, psychological and social change in humans over time.
A hormone produced by the cortex of the adrenal gland, instrumental in the regulation of sodium and potassium reabsorption by the cells of the tubular portion of the kidney.
Hair loss occurring in only one section.
Also called SDAT (senile dementia Alzheimer’s type). This disease is characterized by a general loss of intellectual ability and impairment of memory, judgment and abstract thinking, as well as changes in personality. Other symptoms include loss of speech, disorientation and apathy. Alzheimer’s disease is the most common cause of dementia, rarely occurring before the age of 50. The disease takes from a few months to four or five years to progress to complete loss of intellectual function.
Any group of drugs that stimulate the central nervous system, resulting in elevated blood pressure, heart rate and other metabolic functions.
A class of steroid hormones related to the hormone testosterone. They increase protein synthesis within cells, which results in the buildup of cellular tissue (anabolism), especially in the muscles.
A steroid hormone, such as testosterone or androsterone, that promotes male characteristics.
The male counterpart of menopause, when the production of testosterone decreases and there are accompanying mental symptoms.
A condition marked by a deficiency of red blood cells or of hemoglobin in the blood, resulting in pallor and weakness.
Medicine focused on preventing, slowing, or reversing the effects of aging and helping people live longer, healthier, happier lives.
Distress or uneasiness of mind caused by fear of danger or misfortune; a state of apprehension.
An enzyme or complex of enzymes that promotes the conversion of an androgen (like testosterone) into estrogens (like estradiol).
A basic standard or level; guideline that can serve as a comparison or control.
Benign Prostatic Hyperplasia (BPH)
The increased size of the prostate in middle-aged and elderly men. Also referred to as nodular hyperplasia, benign prostatic hypertrophy or benign enlargement of the prostate (BPE).
An ingredient used to bind together two or more other materials (ingredients) in mixtures: a binder used in medication.
The degree to which or rate at which a hormone or other substance is absorbed or becomes available at the site of physiological activity. (bio-available)
Identical to the substance in the human body; bioidentical estrogen.
Bioidentical Hormone Replacement Therapy (BHRT)
Used to describe hormone supplementation for female menopause with estradiol and progesterone, or male menopause with testosterone, but can also include dehydroepiandrosterone (DHEA), estriol or estrone. BHRT is part of a growing practice of restorative endocrinology of restoring several well-known human hormones to optimal levels and effects with the use of bioidentical hormones.
Substances with the exact same molecular structure as those made in the human body, which produce the same physiologic responses as the body’s natural hormones.
A Laboratory analysis performed on a blood sample that is usually extracted from a vein in the arm using a needle, or via a fingerprick.
C-reactive protein (CRP)
An inflammatory marker – a protein that the body releases in response to inflammation. Thus, elevated levels of CRP in the blood mean that there is inflammation somewhere in the body. CRP is not normally present in the blood of a healthy patient. CRP levels can increase by as much as 1000-times with inflammation. Conditions that commonly lead to marked changes in CRP include infection, trauma, surgery, burns, inflammatory conditions, and advanced cancer. Moderate changes occur after strenuous exercise, heatstroke, and childbirth. Psychological stress and some psychiatric illnesses can cause small changes in CRP levels. CRP is the only inflammatory marker that has been found to be an indicator of heart health. Therefore, doctors often carry out a CRP test at the same time as cholesterol and other lipid tests to help predict a patient’s risk of heart attack.
A usually microscopic structure containing nuclear and cytoplasmic material enclosed by a semi-permeable membrane; the basic structural unit of all organisms.
The interface between the cellular machinery inside the cell and the fluid outside. A semi-permeable lipid bilayer found in all cells containing biological molecules, primarily proteins and lipids.
Central Sleep Apnea
A central nervous system disorder in which the brain signal for breathing is delayed. Often caused by injury or disease affecting the brain stem.
An approximate daily periodicity, a roughly 24-hour cycle in the biochemical, physiological or behavioral processes of living beings. These rhythms allow organisms to anticipate and prepare for precise and regular environmental changes.
Complete Blood Count
A test that gives information about the cells in a person’s blood including the white blood cells (leukocytes), red blood cells (erythrocytes) and platelets.
To produce or create by combining two or more ingredients or parts: pharmacists compounding prescriptions.
A specialized pharmacy that hand makes individualized bioidentical hormone prescriptions. (compounding pharmacies)
To cause a substance to undergo a chemical change. (conversion)
A yellow, progesterone-secreting mass of cells that forms from an ovarian follicle after the release of a mature egg.
A steroid hormone produced by the adrenal gland which regulates carbohydrate metabolism, stress and maintains blood pressure. Also called hydrocortisone.
A form of chemical bonding that is characterized by the sharing of pairs of electrons between atoms, or between atoms and other covalent bonds.
CreatinineCreatinine is a normalizing parameter used to calculate neurotransmitter levels. Creatinine is produced at a constant rate through the kidneys. Therefore, by using creatinine as the constant factor, spot urinary measurements can be performed with out having to factor in the patient’s hydration state, possible renal disorders or diuretic substances that may have been used.
The amount lacked; a shortage: an estrogen deficiency or vitamin deficiency.
Of, relating to, involving, or tending to cause degeneration; to diminish in quality, esp. for a former state of coherence, balance, integrity, etc.
A steroid hormone naturally produced by the adrenal glands and sold in synthetic form as a nutritional supplement.
A condition of general emotional dejection and withdrawal; sadness greater and more prolonged than that warranted by any objective reason.
A conversion of testosterone that is considered to be an aging-bio-marker. Among its affects are the appearance of body-hair, the loss of scalp hair and the onset of prostate gland problems.
Any kind of medical test performed to aid in the diagnosis or detection of disease or poor health.
A disturbance in physical or mental health or functions.
The cumulative effect that results when one event precipitates a series of like events.
DopamineDopamine is an excitatory and inhibitory neurotransmitter, depending on the dopaminergic receptor it binds to. It is derived from the amino acid tyrosine. Dopamine is the precursor to norepinephrine and epinephrine, which are all catecholamines. The function of dopamine is diverse but plays a large role in the pleasure/reward pathway (addiction and thrills), memory, and motor control. Dopamine, like norepinephrine and epinephrine, is stored in vesicles in the axon terminal. Dopamine plays a significant role in the cardiovascular, renal, hormonal, and central nervous systems. The dopaminergic neurons have dendrites that extend into various regions of the brain, controlling different functions through the stimulation of adrenergic and dopaminergic receptors (D1 ?D5). Common symptoms with low dopamine levels are loss of motor control, addictions, cravings, compulsions, and loss of satisfaction. When dopamine levels are elevated symptoms may manifest in the form of anxiety or hyperactivity. Some therapies utilize L-DOPA for parkinsonian symptoms which can also cause elevations in dopamine.
Dopamine MetaboliteAfter neuronal dopamine is released it is inactivated primarily via reuptake mechanisms that remove it from the synapse and the extraneuronal space and return it to the presynaptic dopaminergic neuron or adjacent noradrenergic neurons. Some of the enzymes that degrade dopamine are only found in specific regions of the body. As such some dopamine metabolites are only produced in specific tissues. Understanding how and where these enzymes function can provide valuable insight about how dopamine is functioning in specific regions of the body. In order to understand these functions one must first realize Monoamine oxidase (MAO) is an enzyme present within the cytoplasm of neurons that breaks down dopamine to DOPAL. DOPAL in turn is very rapidly converted to DOPAC by a second cytoplasmic enzyme aldehyde dehydrogenase (AD). Because both of these enzymes are primarily found inside neurons, DOPAC levels are dependent on the amount of cytoplasmic dopamine. Combined measurements of DOPAC and dopamine have been used to assess the activity of dopaminergic neurons. This combination provides additional information than either parameter alone because a large portion of DOPAC is formed from dopamine without ever being released to the synaptic cleft. This suggests that DOPAC may be more closely related to the presynaptic dopamine levels while dopamine and similarly HVA levels, another important metabolite of dopamine that is formed outside of the neuron via the actions of catechols-O-methyltransferase (COMT), are related to the rate of neuron signaling. Said another way, extracellular DOPAC is related to the amount of dopamine made and stored in the presynaptic neuron while extracellular dopamine levels are related to the rate of dopamine released via the depolarization of dopamine neurons.
The amount of medicine to be given.
A type of scientific experiment in which neither the subjects nor the researchers know who is receiving an active substance and who is receiving a placebo. Researchers who do not know which subjects received the active substance then usually evaluate the data generated from the experiment. This type of experiment helps to eliminate personal bias from research.
The presence of uterine lining in other pelvic organs, esp. the ovaries, characterized by cyst formation, adhesions and menstrual pains.
Those determinants of disease that are not transmitted genetically and may determine the development of disease in those genetically predisposed to a particular condition. Environmental factors include stress, physical and mental abuse, diet, exposure to toxins, pathogens, radiation and chemicals found in almost all personal care products and household cleaners are common environmental factors that determine a large segment of non-hereditary disease.
EpinephrineEpinephrine, also known as adrenaline, is an excitatory neurotransmitter and hormone essential for lipolysis, which is a process in which the body metabolizes fat. Epinephrine is derived from the amine norepinephrine. As a neurotransmitter, epinephrine regulates attentiveness and mental focus. Epinephrine is synthesized from norepinephrine.As a hormone, epinephrine is secreted along with norepinephrine principally by the medulla of the adrenal gland. Heightened secretion can occur in response to fear or anger and will result in increased heart rate and the hydrolysis of glycogen to glucose. This reaction, referred to as the “fight or flight” response, prepares the body for strenuous activity. Epinephrine is used medicinally as a stimulant in cardiac arrest, as a vasoconstrictor in shock, as a bronchodilator and antispasmodic in bronchial asthma, and anaphylaxis. Commonly, epinephrine levels will be low due to adrenal fatigue (a pattern in which the adrenal output is suppressed due to chronic stress). Therefore, symptoms can be presented as fatigue with low epinephrine levels. Low levels of epinephrine can also contribute to weight gain and poor concentration. Elevated levels of epinephrine can be factors contributing to restlessness, anxiety, sleep problems, or acute stress.
Difficulty in achieving or maintaining an erection of the penis; impotence.
The most powerful female hormone that occurs naturally. An estrogenic hormone produced by the ovaries and used in treating estrogen deficiency and certain menopausal and postmenopausal conditions.
An estrogenic hormone occurring in urine during pregnancy; used in conditions involving estrogen deficiency.
Any of several steroid hormones produced chiefly by the ovaries and responsible for the development and maintenance of female secondary sex characteristics.
A condition in which a person has excess amounts of estrogen in the body.
An estrogenic hormone produced by the ovarian follicles and found during pregnancy in urine and placental tissue; used in the treatment of estrogen deficiency and certain menopausal and postmenopausal conditions.
Weariness or exhaustion of the mind or body from labor, exertion, or stress.
A benign tumor composed of fibrous or muscle tissue, especially one that develops in the uterus.
A syndrome characterized by chronic pain in the muscles and soft tissues surrounding the joints, fatigue and tenderness at specific sites in the body. Also called fibromyalgia syndrome, fibromyositis, fibrositis.
Follicle Stimulating Hormone
A gonadotropic hormone of the anterior pituitary gland that stimulates the growth of follicles in the ovary and induces the formation of sperm in the testes.
Loss of remembrance or recollection; a ceasing to remember. Also called memory loss, foggy thinking, or foggy memory.
Harmful molecules that cause damage in the body; leading factors in the development of blood vessel disease (atherosclerosis), cancer and other conditions. Byproducts of normal body processes, byproducts of the breakdown of certain medicines, found in pollutants.
GABAGABA is a true neurotransmitter and is the major inhibitory neurotransmitter of the brain, occurring in 30-40% of all synapses. GABA is second only to glutamate, the brain’s major excitatory neurotransmitter. The GABA concentration in the brain is 200-1000 times greater than that of the monoamines or acetylcholine. The primary function of GABA is to prevent overstimulation. It does so by compensating for glutamate activity.; When GABA activates its receptor it causes negative ions to flow into the cell preventing depolarization. Glutamate can depolarize the cell and form an action potential by causing positive ions to flow into the cell when it activates its receptors. Overall, GABA regulates the activity of glutamate by preventing depolarization of the cell, therefore, preventing overstimulation.
Secretion of milk from the breast of a non-lactating person.
Gamma-Aminobutyric Acid (GABA)
A neurotransmitter of the central nervous system that inhibits excitatory responses.
GlutamateGlutamate is the major excitatory neurotransmitter in the brain which is necessary for memory and learning. In fact, it is believed that 70% of the fast excitatory CNS synapses utilize glutamate as a transmitter. Excitatory neurotransmitters increase the activity of signal-receiving neurons and play a major role in controlling brain function. Glutamate exerts its effects on cells, in part, through three types of receptors that, when activated, allow the flow of positively charged ions into the cell. These include the ionotropic receptors: kianate, alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), and N-methyl-D-aspartate (NMDA) receptors. There are also series metabotropic glutamate receptors that do not directly manipulate an ion channel.; Of the ionotropic receptors, the N-methyl-D-aspartate (NMDA) receptor plays a particularly important role in controlling the brain’s ability to adapt to environmental and genetic influences which is important for learning and memory.
GlycineGlycine is a principal inhibitory amino acid in the brainstem and spinal cord that regulates excitatory neurotransmission in much the same way as GABA. Glycine, much like GABA and taurine, can become elevated to compensate for elevations in excitatory neurotransmitters, primarily, glutamate and aspartic acid. This non-essential amino acid is common in protein-based foods, and can be synthesized metabolically from a number of different amino acids, including serine and threonine.; Curiously, glycine is a necessary cofactor in the activation of the glutamate receptor, NMDA. It seems paradoxical that a primarily inhibitory amino acid facilitates the activation of an excitatory receptor. It has been postulated that glycine’s inhibitory and excitatory actions are part of the many checks and balances the body has for regulating neurotransmission.
Growth Hormone (GH)
A hormone secreted by the pituitary gland. GH stimulates growth and repair of the body as well as the activities of the immune system. With age, GH release diminishes (also known as HGH or human growth hormone).
Abnormal enlargement of the breasts in a male.
The medical description of the loss of hair from the head or body, sometimes to the extent of baldness, that is involuntary and unwelcome. In some cases, it is an indication of an underlying medical concern, such as iron deficiency. Also called alopecia.
The general condition of the body or mind with reference to soundness and vigor.
HistamineHistamine is an excitatory neurotransmitter involved in the sleep/wake cycle and inflammatory response. Depending on the receptor histamine activates a wide array of biological actions can occur. For instance, one receptor helps regulate the sleep/wake cycle whereas another receptor helps regulates norepinephrine, serotonin, and acetylcholine release. There are also other receptors that may be activated to induce inflammatory response, which is commonly associated with the exposure to an allergen.
Latin for a chemical messenger, such as growth hormone, testosterone or insulin.
Hormone Pellet Therapy
A sustainable delivery method or treatment option for bioidentical hormone therapy. Every three to six months a pellet made of bioidentical hormones is inserted just under the patient’s skin. The pellets, which contain customized levels of estradiol or testosterone, react to the needs of the body, so they actually dissolve releasing the bioidentical hormones as needed.
The use of hormones in medical treatment. Also called hormonal therapy.
A sudden feeling of feverish heat typically as a symptom of menopause. Also called a hot flush.
Pathologically excessive production of the thyroid hormones.
Diminished hormonal or reproductive functioning in the testes or the ovaries.
An area of the brain that is believed to be the command center for instructions to the endocrine system.
Deficient activity of the thyroid gland.
Surgical removal of part or all of the uterus. Also called surgical menopause.
Lack of proportion or relation between corresponding things: the condition is caused by a hormone imbalance.
Inability to obtain sufficient sleep, especially when chronic; difficulty in falling or staying asleep. Also called sleeplessness.
A urinary bladder disease of unknown cause characterized by urinary frequency, urgency, pressure and/or pain in the bladder and/or pelvis. Also known as painful bladder syndrome (PBS).
An element required in small amounts for healthy growth and development. The thyroid gland requires iodine to synthesize thyroid hormones; a deficiency of the element leads to goiter.
Easily irritated or annoyed; readily excited to impatience or anger.
Irritable Male Syndrome
The term for a set of symptoms caused by a drop in testosterone levels in males. These symptoms are similar to those of the male menopause or andropause. One of the most consistent symptoms is anger and sullen withdrawal present in men between the ages of 40 and 60.
A small surgical instrument, usually sharp-pointed and two-edged, for making small incisions, opening abscesses, etc.
Sexual urge or desire.
A long individual life; great duration of individual life.
A hormone produced by the anterior lobe of the pituitary gland that stimulates ovulation and the development of the corpus luteum in the female and the production of testosterone by the interstitial cells of the testes in the male.
Any of the various white blood cells, including B-cells and T-cells, that function in the body’s immune system by recognizing and deactivating specific foreign substances called antigens. B-cells act by stimulating the production of antibodies. T-cells contain receptors on their cell surfaces that are capable of recognizing and binding to specific antigens. Lymphocytes are found in the lymph nodes and spleen, and circulate continuously in the blood and lymph.
A hormone derived from serotonin and secreted by the pineal gland in inverse proportion to the amount of light received by the retina. Darkness perceived by the retina (or sleep) induces greater production which has been linked to the regulation of circadian rhythms and inducing sleep rhythms.
Of, pertaining to, or characteristic of menopause.
The period of permanent cessation of menstruation, usually occurring between the ages of 45 and 55.
A recurring cycle in which the endometrial lining of the uterus prepares for pregnancy; if pregnancy does not occur the lining is shed at menstruation. The average menstrual cycle is 28 days, day 1 being the beginning of bleeding.
The periodic discharge of blood and mucosal tissue from the uterus, occurring approximately monthly from puberty to menopause in non-pregnant women.
The rate of metabolism; the amount of energy expended in a given period.
The sum of the physical and chemical processes in an organism, by which its material substance is produced, maintained and destroyed and by which energy is made available.
Substances necessary for taking part in a particular metabolic process, such as glucose in the metabolism of sugars and starches, and amino acids in the biosynthesis of proteins.
To reduce to particles that are only a few microns in diameter.
A period of psychological stress occurring in middle age, thought to be triggered by a physical, occupational, or domestic event, such as menopause or andropause, diminution of physical prowess, job loss, or departure of children from the home.
A blood draw or venesection at a different location than the normal doctor’s office or laboratory; usually at a patient’s home.
A single very small particle, made up of atoms, which is indivisible.
An abrupt and apparently unaccountable change of mood.
Any of several chemical substances, such as epinephrine or acetylcholine, that transmit nerve impulses across a synapse to a postsynaptic element, such as another nerve, muscle or gland.
Copious sweating during sleep. Night sweats may be an early indication of tuberculosis, AIDS, or other disease.
Works as a signaling molecule in the cardiovascular system. Cells of a blood vessel’s inner walls use nitric oxide to signal the vessel to relax and dilate, increasing blood flow.
NorepinephrineNorepinephrine is an excitatory neurotransmitter that is important for attention and focus. Norepinephrine is synthesized from dopamine by means of the enzyme dopamine beta-hydroxylase, with oxygen, copper, and vitamin C as co-factors. Dopamine is synthesized in the cytoplasm, but norepinephrine is synthesized in the neurotransmitter storage vesicles.; Cells that use norepinephrine for formation of epinephrine use SAMe as a methyl group donor. Levels of epinephrine in the CNS are only about 10% of the levels of norepinephrine.
Obstructive Sleep Apnea
Sleep apnea that is caused by recurring interruption of breathing during sleep because of the obstruction of the upper airway by weak or malformed pharyngeal tissues, that occurs especially in obese middle-aged and elderly men, and that results in hypoxemia and chronic lethargy during the day. Also called obstructive sleep apnea syndrome.
Sold legally without a doctor’s prescription: over-the-counter drugs.
To produce and discharge eggs from an ovary or ovarian follicle.
A degenerative disorder of the central nervous system characterized by tremor and impaired muscular coordination.
PEABeta-phenylethylamine (PEA) is an excitatory neurotransmitter derived from the amino acid phenylalanine.Studies have found that PEA promotes energy and elevates mood. PEA also functions as a synaptic neuromodulator inhibiting the reuptake of dopamine and norepinephrine. Studies have discovered that patients with depression have decreased PEA levels while increased levels have been found in patients with psychopathic symptoms. It has also been implicated in headaches and the antidepressant effects of exercise.; One of the biochemical abnormalities resulting from phenylketonuria, the absence of the enzyme that helps to synthesize phenylalanine into tyrosine, is an increased production of PEA. This can cause an elevated level of PEA in the urine. Since PEA is lipid soluble and readily crosses the blood-brain-barrier, the administration of PEA or of its precursor, phenylalanine, has been found to improve outcome with some antidepressants. Also, supplementation to manipulate PEA can help increase focus and attention.
The period around the onset of menopause that is often marked by various physical changes, such as hot flashes and menstrual irregularity. Also called peri-menopause, early menopause or pre-menopause.
The act or practice of opening a vein for letting blood as a therapeutic measure. Also called venesection.
PhytoestrogensSometimes called “dietary estrogens”, are a diverse group of naturally occurring non steroidal plant compounds that, because of their structural similarity with estradiol, have the ability to cause estrogenic or/and antiestrogenic effects.
A gland at the base of the brain. The pituitary secretes several different hormones involved in key metabolic processes.
All of the time in a woman’s life that take place after her last period ever, or more accurately, all of the time that follows the point when her ovaries become inactive. A woman who still has her uterus can be declared to be in post menopause once she has gone 12 full months with no flow at all, not even any spotting. Also seen as postmenopause or post-menopause.
A chemical that can be converted by the body into another is a precursor of the latter chemical.
An unsaturated hydroxyl steroid that is formed by the oxidation of steroids (like cholesterol) and yields progesterone on dehydrogenation.
Premenstrual Syndrome (PMS)
A varied group of physical and psychological symptoms, including abdominal bloating, breast tenderness, headache, fatigue, irritability, anxiety and depression that occur from 2 to 7 days before the onset of menstruation and cease shortly after menses begins.
A direction, usually written by the physician to the pharmacist for the preparation and use of a medicine or remedy.
Measures taken to prevent illness or injury, rather than curing them. Preventive care may include examinations and screening tests tailored to an individual’s age, health and family history. Also called preventive care or preventative medicine.
A hormone that prepares the uterus for the fertilized ovum and maintains pregnancy.
A protein hormone produced by the pituitary gland of mammals that acts with other hormones to initiate the secretion of milk by the mammary glands. It also acts to maintain the corpus luteum of the ovary, which is the source of the female sex hormone progesterone. In males, high levels of prolactin can cause testosterone levels to decrease.
Prostate Specific Antigen (PSA)
A protein produced by the cells of the prostate gland. PSA is present in small quantities in the serum of normal men and is often elevated in the presence of prostate cancer and in other prostate disorders.
A molecular structure or site on the surface or interior of a cell that binds with substances such as hormones.
Reverse Triiodothyronine (Reverse T3)
A molecule which is an isomer of triiodothyroniine and derived from thyroxine through the use of deiodinase. Blocks the action of T3.
The act of injecting oneself with a drug or other substance.
SerotoninSerotonin is an inhibitory neurotransmitter synthesized by enzymes that act on tryptophan and/or 5-HTP. Serotonin is stored in presynaptic vesicles and released to transmit electrochemical signals across the synapse. Extensive research has been conducted surrounding serotonin and acts as a target for symptoms like low mood, compulsions, anxiousness, and headaches. Serotonin acts, in most cases, as an inhibitory neurotransmitter and, like GABA, modulates neuron voltage potentials to inhibit glutamate activity and neurotransmitter firing. Serotonin neurons have large numbers of axons and are important in integrating neural circuits. This also provides an explanation for serotonin’s role in so many health concerns.
An inhibitory neurotransmitter required for sleep.
Serotonin Metabolite5-Hydroxyindoleacetic acid (5-HIAA) is a major metabolite of serotonin, generated via a two step process, involving monoamine oxidase A (MAO-A) and aldehyde dehydrogenase. Measurement of 5-HIAA in combination with serotonin may offer insight into mechanisms underlying various clinical symptoms. The ratio of serotonin to 5-HIAA may be used to evaluate serotonin turnover and monoamine oxidase activity. Abnormal levels of 5-HIAA have been associated with depression, suicidal behaviors, aggression, chronic psychotropic medication use, and Parkinson’s Disease.
The clear yellowish fluid obtained upon separating whole blood into its solid and liquid components after it has been allowed to clot.
A physiological need for sexual activity.
Any of a class of steroid hormones that regulate the growth and function of the reproductive organs or stimulate the development of the secondary sexual characteristics.
Sex Hormone-Binding Globulin (SHBG)
A glycoprotein produced by the liver cells that binds to sex hormones, specifically testosterone and estradiol.
A temporary suspension of breathing occurring repeatedly during sleep that is caused especially by obstruction of the airway or a disturbance in the brain’s respiratory center and is associated especially with excessive daytime sleepiness.
Any hormone containing the characteristic steroid ring complex; a term often associated with hormones such as progesterone, testosterone, estrogens, DHEA, and others.
Physical, mental, or emotional strain or tension; a specific response by the body to stimulus, as fear or pain, that disturbs or interferes with the normal physiological equilibrium of an organism.
An agent, condition or other stimulus that causes stress to an organism.
A subjective indication of a disorder reported by an afflicted person rather than being observed by an examiner.
Hormones made from plant progesterone and animal chemicals that are bio-similar but not identical to the hormones your body uses. Generally, an extra covalent bond or molecules are added so that it can be patented or to alter it’s chemical properties or clinical effects. Being non-identical to the body may cause significant harmful side effects.
TaurineTaurine is an inhibitory neurotransmitter involved in neuromodulatory and neuroprotective actions. Supplementing with taurine can have a specific effect on GABA function.There are two primary ways in which taurine affects GABA.; First, it can inhibit GABA transaminase, an enzyme that metabolizes GABA. This allows GABA to stay in the synaptic cleft longer to bind to the postsynaptic receptor. Second, taurine can bind to the GABAAreceptor mimicking the effects of GABA. By helping GABA function, taurine is an important neuromodulator for prevention of excitoxicity. Excitability occurs when glutamate binds to its receptor, in this case, the NMDA receptor. Once glutamate activates the NMDA receptor there is an increase in intracellular Ca++ causing depolarization or cell excitability. With glutamate release, there is also simultaneous GABA and taurine release. When the inhibitory neurotransmitters, GABA and taurine, activate the GABAA receptor, the result is an increase in intracellular Cl- ions. This results in hyperpolarization which reduces cell excitability. Thus, the overall effect of taurine supplementation is to support GABA function. The relevance of GABA support is to prevent overstimulation due to high levels of excitatory amino acids. Therefore, taurine and GABA constitute an important protective mechanism against excessive excitatory amino acids. Similarly, taurine is increased in response to the exposure of free radicals elucidating its neuroprotective actions. Exposure to free radicals increases glutamate excretion, further potentiation NMDA receptor activation. Taurine modulates this effect to prevent cell excitability by keeping the cell hyperpolarized. The supplementation of taurine can help alleviate some excitability issues associated with elevated excitatory amino acids as well as play a role in regulating the effect of free radicals.
A potent Androgenic hormone produced chiefly by the testes, which stimulates the development of male sex organs, secondary sexual traits and sperm.
The gland located in the center and anterior aspect of the neck responsible (amongst other things) for temperature regulation.
Thyroid Peroxidase (TPO)
An enzyme mainly expressed in the thyroid that liberates iodine for addition onto tyrosine residues on thyroglobulin for the production of T4, T3 and reverse T3.
Thyroid Stimulating Hormone (TSH)
A glycoprotein hormone secreted by the anterior portion of the pituitary gland that stimulates and regulates the activity of the thyroid gland. Also called thyrotropin.
The thyroid gland iodine-containing hormone that regulates the metabolic rate of the body; used in the treatment of hypothyroidism.
A blood plasma protein for iron ion delivery.
A thyroid hormone derived from thyroxine but several times more potent; used in treating hypothyroidism
TyramineTyramine (4-hydroxy-phenethylamine) is a naturally occurring monoamine compound formed by the enzymatic decarboxylation of the aromatic amino acid tyrosine. The enzyme monoamine oxidase is responsible for the breakdown of tyramine. When this metabolic pathway is compromised by monoamine oxidase inhibitors (MAOIs), tyramine levels can become elevated and cause the release of neurotransmitters, such as dopamine, norepinephrine, and epinephrine, potentially leading to an increase in blood pressure. Dietary intake of tyramine has also been associated with cluster headaches and migraines, forcing many to restrict foods containing tyramine such as fish, chocolate, alcohol, and fermented foods including cheese, processed meat, and sauerkraut.
Any involuntary leakage of urine.
Loss of muscle tension in the vagina.
The condition in which vaginal lubrication is insufficient causing increased friction and discomfort during sexual intercourse.
The naturally produced lubricating fluid that reduces friction during sexual intercourse.
Substances or pollutants originating outside the body that have estrogen-like activities. Exposure to these substances can have a profound impact on a person’s natural hormonal balance.
Substances or pollutants originating outside the body that have hormone-like activities. Exposure to these substances can have a profound impact on a person’s natural hormonal balance.


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Green Bean Harvester
Ideal machine for small allotments, greenhouses and plants lines.
3-points hitch with hydraulic conveyor to center the line.
Picker reel equipped with flexible teeth made of steel.
N° 1 fan – supplementary fan on demand.
N° 1 rear wheel to adjust the harvesting height.
Carrying elevator belt.
Cardan shaft equipped with automatic limiting device
MINIRACCOGLITRICE PORTATA MONOFILA RF3 per fagioli e fagiolini da mercato fresco
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Retail sales volumes jumped 5.2% in January as fashion, footwear and homewares retailers reaped the rewards of the winter chill.
The busier month of trading came as a boost to retailers after sales volumes dipped 1% in December, due to the Black Friday effect and unseasonably warm weather.
“The prospects for 2016 look positive, as shoppers continue to find themselves with more to spend thanks to a mix of falling food and fuel prices and rising wages”
Keith Richardson, Lloyds Bank Commercial Banking
Non-food stores collectively recorded a 4.6% increase in volumes during January, with household goods specialists posting a 3% uplift, according to the Office for National Statistics.
Sales volumes increased 6.8% in department stores last month, while online sales volumes jumped 11.5% on the year.
The amount of good purchased in food stores rose 4.2% compared to January 2015, but sales values only increased 1.4% as ongoing food deflation drove average prices down 2.4%.
Grocers were not the only retailers to report falling prices though, as average prices decreased 1.8% in general merchandise stores and 1.9% in department stores.
That drove sales values up 6.6% in department stores and 2.8% in non-food stores. The value of online sales increased 10.4% in January, as the average weekly ecommerce spend hit £863.5m.
The overall 5.2% rise in sales volumes compared to the same period in 2015 marked the 33rd consecutive month of year-on-year volume growth. Retail sales also advanced 2.3% on a monthly basis, the ONS said.
Keith Richardson, managing director of the retail sector at Lloyds Bank Commercial Banking, attributed non-food retailer’s sales uplifts to the “long overdue arrival of winter”.
“A cold snap brought shoppers flocking to the high street looking for winter coats, jumpers and footwear, while bargain-hunters sought to maximise on the post-Christmas sales by buying big-ticket items such as furniture and other homeware,” Richardson added.
“Having got off to a good start, the prospects for 2016 look positive, as shoppers continue to find themselves with more to spend thanks to a mix of falling food and fuel prices and rising wages.
“But with headwinds such as the introduction of the national living wage and proposals to change Sunday trading hours on the horizon, retailers will need to protect margins more than ever this year.
“Maximising online to open up new markets, while also trying to persuade shoppers to break their bargain habit, are still the major goals.”

domain: economics


text:
Fandom: Jeff and Michael Shaara - Civil War Trilogy
Summary: As the Union moves inexorably toward civil war, three people share a quiet interlude. If only that moment never had to end. (Winfield Hancock, Mira Hancock, Lewis Armistead)
Length: 9:16 / 6.36MB (mp3)
Music: "Kathleen Mavourneen" from the Gettysburg soundtrack
Link: Temporary link here
Point value: 5 + 2 + (3+3) = 13.
Notes: I'm not sure how many people are familiar with this universe but in a nutshell, it's historical fiction from the (US) Civil War. The books are amazing and this is the only fic I've found that takes place in this universe. (Hurray for Yuletide!)
Big thanks to bethbethbeth, who wrote this truly beautiful piece and was lovely enough to let me record it -- I hope I was able to do this justice.
crossposted to my journal

domain: artistic


LONDON (MarketWatch) -- Lockheed Marting Corp. LMT, +2.07% said it has won a $208.7 million contract with the U.S. Navy to produce three Aegis Weapons Systems. The Aegis Weapon System is the world's premier naval surface defense system and the sea-based element of the U.S.'s Ballistic Missile Defense System.
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text:
Closing the gender wage gap is a key priority for many organizations—for reasons that go far beyond fairness. Research shows that gender-diverse companies are more likely to outperform than their less diverse peers, and establishing an equitable pay policy is an important step forward. Gender diversity—or lack thereof—can affect employer brand, and proposed changes to U.S. pay equity legislation are also driving urgency.
But in spite of considerable attention from both government and business, the wage gap has only improved by 8% in the last 20 years. What’s slowing down progress, and what can employers do about it?
In this on webinar, people analytics expert Dave Weisbeck will review findings from a new study based on workforce data from large U.S. employers. In the webinar, you’ll get:

domain: sociology


text:
Ocean of Flowers A4 Art Print
“Colourful creatures dip and dive amongst the garden bed, their shiny scales caching the light like precious stones. Gently we bob along on a sea of vines and violet petals, drifting somewhere between two worlds. ” -NM
Hand illustrated art print designed and printed in Melbourne, available in A4 size.
Signed and dated by artist Emily May.
Bring your space to life with this whimsical artist designed illustration.
Printed with rich vibrant inks on bespoke cotton paper to look wonderful on your walls.
Beautifully packaged with a vintage book inspired backing board making a playful unique gift without needing a frame.


text:
Please Note: This event has expired.
Cultural Gems, Love in Any Language: Amour, Amore, Amore...
Jazz Duo Sonny and Perley delight us with a performance of songs in some of the world's most beautiful languages. They will share their love of culture by giving us the background and translation of many of the favorites that we have heard for years.
INDIVIDUAL DATES & TIMES*
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1 - 2 pm
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domain: entertainment


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July 17, 2019
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domain: design


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Spray fur dye, and add shiny accessories to your own fluffy cat! This animal dress-up game gives you access to tons of fun pet decorations. You can try different patterns and bows on your kitty's tail. Add a bracelet, ring, and collar to complete the feline makeover!
Report game as broken
Cancel report of broken game

domain: game


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As I proudly — and gratefully — begin the year as chair of the American Association of Community Colleges (AACC) board of directors, I am reminded of an unusual fact.
In 1967, when I joined the English faculty at Prince George’s Community College (Maryland), I — along with many others like me — became a pioneer as the community college movement spread across the country. Now 50 years later, as the president of the Community College of Baltimore County, I fiercely embrace the spirit of becoming a pioneer once again as America’s community colleges retool for the 21st century.
In 1967 we were academic innovators, creating a new form of higher education with the metaphoric equivalent of duct tape, bobby pins and chewing gum. We since have matured into a powerful sector that serves 12 million students a year. Each one of those 12 million deserves the best education and training we can offer, equipping them to meet the challenges of this century rather than the last.
This column comes from the new August/September issue of AACC’s Community College Journal. Read it online.
This is not merely a matter of adapting 1970s processes and practices to a computer. Instead, we face the challenge of creating cutting-edge currency in everything we do: curriculum, facilities, equipment, institutional systems and faculty/staff expertise. We must do the hard things necessary to make this happen as gently as we can – not only to reduce the human collateral sometimes associated with rightsizing, but to understand that for most of us there will be no new money, unless we find a way to generate it ourselves.
A new world with new challenges
Does this mean higher education is in crisis? I say a resounding NO. We are in motion, rapidly hurtling toward some new point of stasis that differs vastly from the one that shaped the community college in the last century.
For those of us who must lead this transformation, there are several challenges. First, we must continue to embrace and celebrate the magic of our open-door mission, while simultaneously ensuring that the equity equation remains a fixed part of this “access to success” matrix.
Second, in an era of acute enrollment decline, rightsizing our institutions to a size appropriate to our resources is of paramount importance. We must be creative in our quest for cost-savings, engaging people who are most impacted by tightening budgets into thoughtful conversations to find solutions.
Third, launching a serious review of internal processes, systems and products throughout the institution will serve to strengthen and improve both content and delivery, while bringing economic stability to the institution.
As AACC prepares to celebrate its 100th year in 2020, I am proud to serve as AACC board chair. More than any other sector of higher education, it is the community college that America turns to for postsecondary credentials. Every day we earn our stripes as democracy’s colleges. This is our mission. This is who we are. This is who we serve.
And I ask you, as I ask myself, if we do not support these students, who will? The answer lies in our resilience, flexibility and motivation. Just as we have grown, progressed and advanced to meet the changing demands of students through decades past, so will we rise to meet the developmental, academic and career training needs of students today and into the future.


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Anvi Gold Pendant - Moonstone
Be kind to the earth and she will be kind back. Mother Nature has powers all of her own to heal and provide energy in the form of semi-precious stones and crystals. Worn close to the heart, this 18ct gold plated pendant sustainably made with love by artisans in Rajasthan, India will suit any outfit as well as energise and protect day to day.
When looking for inner strength, choose pearlescent moonstone, used to create calmness and stabilise emotions. This stone symbolises new beginnings and is said to promote inspiration and motivate for success.


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American Samoa is set to make it legal for some undocumented foreigners to reside in the territory.
The top two political leaders appeared over the weekend on state-run television to officially inform the community about the launch of the Immigration Amnesty Program, aimed to regularise foreigners' immigration status.
The governor Lolo Matalasi Moliga and the lieutenant governor Lemanu Peleti Mauga urged all undocumented foreigners to take advantage of the program.
The registration period runs from February the 18th to March the 14th and Lolo says it's never good to live in fear of being deported due to the status of a person's immigration papers.
Lemanu says immigration problems are very serious and he is aware many foreigners are in the territory without proper papers.
"This amnesty programme will allow everyone the opportunity to make your immigration status legal. We want you to make it right for your children, your family and yourself."
Lemanu Peleti Mauga.


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Map of World Keynote templates contain slides with maps: Antarctica, Saudi Arabia, Tropical forests in Brazil, Rainforests of Central California. Look at what the climate in these areas, estimate the temperature in winter and summer, etc. Download World Keynote Maps for presentation here!
Animation World Keynote maps
Worldwide Vector Map for Keynote Presentation
World Map with Countries for Keynote Presentation
World Map with Country Keynote Presentation
Map of Global World for Keynote Presentation
Central America Maps: Keynote Maps of Central America Presentation

domain: geography


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Cancer Research Postbac (CRP) Program
THE APPLICATION CYCLE FOR THE 2024 CRP PROGRAM WILL OPEN IN LATE FALL
The Cancer Research Postbac (CRP) program (formerly known as Introduction to Cancer Research Careers) provides recent college graduates the opportunity to complete a paid postbaccalaureate fellowship at the National Cancer Institute (NCI). Candidates will have the ability to spend up to 2 years conducting research in basic and clinical research, cancer epidemiology and genetics research, cancer control science, or global health.
As part of this program, fellows will spend up to two years in a cohort program that offers career and professional development, as well as networking opportunities with other NCI and NIH postbacs to support their research. Fellows are also eligible to receive travel support to attend a scientific conference to further enhance their postbac experience.
Benefits of a CRP Fellow
- Sense of community with CRP cohort
- Receive a travel award to encourage presentation of your work at a national meeting
- Professional and career development opportunities to prepare you for medical school or graduate school
- Access to additional training, courses, and workshops to facilitate your project goals
Similar to the general NCI Postbac Program, CRP fellows are expected to spend 40 hours a week conducting research, attending meetings with their research group, and participating in related workshops. However, CRP aims to provide valuable professional development designed to advance your career in biomedical research. The CRP cohort meets monthly, as well as quarterly with postbacs in similar programs across the NIH which builds a sense of community and extends networking opportunities.
Training at NCI makes individuals highly competitive for future academic or job pursuits. Many of our CRP fellows desire to go to medical or graduate school. In combination with the other NIH offerings, our fellows receive application and interview support and are successful at achieving their goals. After completing their postbac, CRP Fellows have typically gone on to complete graduate school or medical school or have entered the scientific workforce.
How to Apply
NCI is committed to training the next generation of scientific leaders, and it is crucial that this reflects the diversity of the population it serves. Candidates from backgrounds underrepresented in biomedical research (NOT-OD-20-031) are strongly encouraged to apply.
The application cycle is currently closed and will open in late fall.
For Additional Information
If you have questions about the program or application process, please contact email@example.com.

domain: biology


2014 Golden Globe Award nominee Daniel Brühl took the brand new Audi TTS Roadster for a quick spin around the streets of Berlin where he owns the Raval tapas bar. Known primarily for his role as Niki Lauda in “Rush”, the actor actually trained in a Formula 3 car in preparation for the movie and has been a fan of fast cars such as the Audi TTS Roadster ever since.
Introduced last year, the open-top sports car is powered by a four-cylinder, 2.0-liter TFSI turbocharged gasoline engine sending 310 HP (228 kW) and 380 Nm of torque to a quattro all-wheel drive system through an S tronic gearbox. It sprints to 62 mph (100 km/h) from a standstill in 4.9 seconds and will top out at an electronically-limited 155 mph (250 km/h). Despite the impressive performances, it manages to remain quite frugal as the Audi TTS Roadster will consume only 6.9 liters / 100 km with corresponding CO2 emissions of 156 g/km.
You can check out the full interview given by Daniel Brühl to Audi Communication’s online magazine at the source link below.
Source: Audi Encounter


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Bankrate.com has named Atlantic City as one of the top ten beach towns with bargain home prices.
The website analyzed foreclosure sales data and found that buyers could purchase a foreclosure in the city for about 30 percent off market value prices.
With an average sales price of just over $161,000, foreclosures in the city account for more than 12 percent of all sales.
Evangelist Franklin Graham prayed on a sidewalk outside the Pentagon Thursday after his invitation to a prayer service inside was withdrawn because of comments that insulted people of other religions. More>>


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Raising a young child comes with both joys and challenges, and no parent is perfect.
To help families do their best in guiding their children’s healthy development, Arizona’s early childhood agency, First Things First (FTF) has partnered with the national early childhood organization, ZERO TO THREE, to promote Positive Parenting, an approach that focuses on building loving relationships with children through everyday moments — even when those parenting moments aren’t easy.
“Parenting is a forever learning process, and all parents want to do the best they can,” said Kat Willard, FTF’s senior director for family support and literacy. “The latest research tells us that when parents make time to connect with their child through everyday moments it helps the child learn how important and cherished they are.”
Research also shows that today’s moms and dads turn to online content, especially videos, when looking for guidance on parenting. That’s why FTF collaborated with ZERO TO THREE on a series of videos and online content that highlight nine elements of Positive Parenting, which include being able to imagine your child’s point of view; providing consistent, age-appropriate guidelines and limits; and recognizing and regulating your own feelings before responding to your child.
Parents and caregivers who visit FTF’s Positive Parenting page will find short videos, parent interviews and other information that will engage and encourage parents of babies, toddlers and preschoolers.
You might be interested in:
For example, one music video reminds parents that a child’s perspective is a lot different so it’s important for parents to try to imagine their child’s point of view, especially during tough moments.
Willard encourages families to find time to connect and delight in the little moments with their child, like during diaper changing or a meal time.
“One of my favorite things to do at meal times with my children is talk about the favorite parts of their day, as well as a part of our day they didn’t like,” she said. “It provides me with the opportunity to respond to my children with interest and sensitivity and to expand on their ideas or thoughts.”
Parents should come to the realization that positive parenting isn’t about being perfect,” said Rebecca Parlakian, ZERO TO THREE’s senior director of programs.
“It’s about building loving connections with our children through everyday routines,” she said. “When we make mistakes, as every parent does, it’s important that we take the time to reconnect with our child and learn from those moments. The power of being a parent is that we get to choose how we build our own family — which patterns to continue from our own childhood and which to leave behind.”

domain: psychology


Panaji: With 4.2 per cent of the adults in Goa addicted to smoking, the Global Audit Tobacco (GATS) has found that 51 per cent of them were either planning to where thinking of quitting the puff (smoking).
Anti-Tobacco NGO National Organisation for Tobacco Eradication (NOTE) today released the findings of GATS survey which was conducted between August, 2016 to February, 2017 in Goa along with 30 states and Union Territories.
The GATS mentions that amongst all the states and union territories where the survey was conducted, Goa had the lowest prevalence of tobacco use.
“The first GATS survey was conducted across the country between June 2009 and January 2010. The latest is the second such survey conducted in the country,” NOTE General Secretary Shekhar Salkar told a press conference today.
GATS findings reveal that 7.9 per cent of men and 0.4 per cent of women and 4.2 per cent of all the adults smoke tobacco in Goa while 9.2 per cent of men, 3.6 per cent of women and 6.5 per cent of all adults opt for smokeless tobacco.
From the first survey which was conducted between 2009-10 till the recent one, the prevalence of smoking in the State has decreased by 0.6 per cent, the survey says adding that the prevalence of smokeless tobacco has increased by 1.9 per cent in the coastal state.
The GATS has also revealed that the mean age of initiation of tobacco is 17.5 years. The survey has revealed that 49.1 per cent of smokers and 44.4 per cent of smokeless tobacco users were adviced by the health care providers to quit smoking.
The survey which was conducted in Goa had interviewed 757 males and 1272 females by visiting different households between 2016-17.
Interestingly, around 20.6 per cent of the tobacco smokers had made attempt to quit it during the year before the survey was conducted, while 51 per cent smokers had planned or were thinking to quit smoking.
The survey also revealed that 17.9 per cent of all adults were exposed to second hand smoke indoors while 13.8 per cent at public places.


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On May 1st 2019, VRDB.com and SlideDB.com were closed. We no longer support VR, AR, iOS or Android only games. We are focused on PC, console and moddable games. If this is your project and you would like to release it on Indie DB, please contact us with the details.
Discover the epic conclusion of the long-time clan warfare between members of the Mishima family. Powered by Unreal Engine 4, the legendary fighting game franchise fights back with stunning story-driven cinematic battles and intense duels that can be enjoyed with friends and rivals.


The Irish women's hockey team have bagged themselves a place in the final of the Hockey World Cup.
The ladies fought a tough game against Spain, and it boiled down to a very tense round of penalties.
Luckily, the Irish team came out stronger in the end and it was team player Gillian Pinder who scored the all-important penalty in a Sudden Death decider.
The girls now have a strong chance of walking away with the trophy, and fans couldn't be happier for them!
IRELAND ARE IN THE FINAL OF THE WORLD CUP!!!!! Incredible hockey! What a game! #HWC2018— Mind The Baby (@MindTheBabyBlog) August 4, 2018
What a team!!! #HWC2018 #greenarmy #worldcup #Believe #COYGIG ☘— amy fitzpatrick (@amyfitzpatric14) August 4, 2018
This will be the Ireland hockey team's first time reaching the final, male team included, and after today's knockout performance fans have high hopes for the girls.
Unbelievable stuff! A historic moment! #greenarmy #COYGIG #HWC2018— Colm Breen (@colmbreen) August 4, 2018
We’ll really shake em up when we win the World Cup Cos Ireland are the greatest hockey team!! @IreWomenHockey #HWC2018— YMCA Hockey Club (@YMCAHC) August 4, 2018
The women will face either the Netherlands or Australia in the final, who will play each other tonight.
From all of us here at RSVP, congrats ladies!


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Colourful cloth diapers on the clothesline.
A colourful bouquet of tulips.
A very colourful shop in St. Martin's, NB.
Each photo was taken with my Canon point and shoot most likely set on Auto. I didn't enhance any of the photos but the tulips were edited with in Picasa with a softening border.
I am joining the Personal Photo Challenge for May that is hosted by Donna at A Personal Photo Challenge where the theme this month is Colourful. If you'd like to join us you will find instructions at the link or you can just visit the other participants there.
Thank you Donna for continuing to host this meme.
I hope you all have a wonderful weekend.


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And two very challenging game modes. Tap to flap Flappy Swines wings to guide him through obstacles in the hospital as far as your luck and concentration allows. The basic helmet allows you to crash into an obstacle once and not die.
- Flappy Swine Flu! The most annoying viral this season!Weak, feverish struggling to breath? It's time to get to hospital before the epidemic takes hold.
Gears"What's new in this version:- Bugs fixed The dragons have taken over the castles and they are trying to protect their kingdoms and the knights are attacking. Somewhere , in a far land , this poor dinosaur was was found by a group of archeologists , and taken away .
What's new in this version:New night mode But be careful - do not hit the dark toasts! Catch Rocket Toasts, Collect Bonuses- and Power Stars, repair defect toasters, get tap-combos and play bonus rounds to beat the high score!Let your fingers fly . Tap to fly up, release your finger to fly down.
You have to get your fly to fly through open sections of the columns to pass on to another level and earn valuable coins.
Experience a whole new slot game with the Asian Dragon Slots! If you are someone who loves slots and enjoy Asian culture, then this certainly is the slot game for you.
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With 1200 levels of gameplay, there is no end to the amount of not matching you can do.


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By Mark Musick Forty years ago today more than 70 people from across the Northwest gathered at Pragtree Farm in Snohomish County to officially form the Tilth Association (the predecessor […]
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