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Blocking iodide transport by inhibiting the sodium iodide symporter
Iodide entrapment in the thyroid gland is essential, and plays a key role in dysfunctions such as thyroid and breast cancers, thyroiditis, Graves–Basedow disease, and Hashimoto's disease.
The accidents at Chernobyl and Fukushima have revealed growing public concerns, as exposure to radioactive iodine increases the risk of cancer and birth defects. There is an urgent need to find radioprotective molecules to prevent and treat body contamination.
Yves Ambroise and colleagues at the Biology and Technology Institute (IBiTecS, France) identified an important class of compounds that efficiently block iodide transport by inhibiting the sodium iodide symporter, and their results are reported in ChemMedChem.
During a hit optimization program, they synthesized and tested more than 100 molecules for their capacity to block iodide entrapment in rat thyroid cells. They identified a new lead compound with nanomolar activity and low toxicity. This discovery opens new perspectives for the development of novel anti-thyroid drugs and radioprotective molecules, as well as pharmacological tools for further investigation of iodide traffic at the cellular level.
About the Author
Yves Ambroise is a research group leader in the Biology and Technology Institute (IBiTecS) at the French Alternative Energies and Atomic Energy Commission (CEA). His main areas of interest are chemical biology and drug discovery using techniques such as high-throughput screening, chemical optimization, and target identification by chemical proteomic methods. His research focuses on the mechanism of iodide uptake in the thyroid gland. He is a member of the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).
Author: Yves Ambroise, Alternative Energies and Atomic Energy Commission, CEA, Gif-sur-Yvette (France), http://www-dsv.cea.fr/institutes/institute-of-biology-and-technology-saclay-ibitec-s/units/molecular-labelling-and-bio-organic-chemistry-scbm/bioorganic-chemistry-laboratory-lcb/transport-and-metabolism-of-iodine-y.-ambroise
Title: Synthesis and Evaluation of 3,4-Dihydropyrimidin-2(1H)-ones as Sodium Iodide Symporter Inhibitors
ChemMedChem 2013, 8, No. 1, Permalink to the article: http://dx.doi.org/10.1002/cmdc.201200417
Yves Ambroise | Wiley-VCH
The most recent press releases about innovation >>>
Die letzten 5 Focus-News des innovations-reports im Überblick:
An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.
Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...
Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.
Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...
Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.
As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...
Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.
With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...
Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine
Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...


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Play & Tune
Hearing aid calibration for the elderly
Play&Tune is specifically oriented towards the elderly as a primary target group and towards hearing aid manufacturers and resellers as a secondary target group.
The application has been developed for PC and Mac, and allows elderly end-users to simulate a series of virtual scenes in which both the sound and a virtual hearing aid can be calibrated (e.g. a restaurant with a lot of people talking around the listener, or a noisy street, etc.) through a set of simple-to-use and engaging gaming applications. While playing, the end-users can calibrate parameters such as left-right levels, noise reduction or directivity.
Decription of the Noisy Street scenario
An gamification scenario can be, for example, one where the player’s 3D avatar is in a 3D space with other characters. These characters speak from different directions and in different contextual and environmental conditions (e.g. initially the environment is very quiet, then it becomes noisier and noisier). Within these changing environmental conditions, the player has to correctly identify the words pronounced by these characters, or provide the right answer to their questions. During the game, the player can fine tune various parameters connected to her/his hearing.
Play & Tune can be downloaded and purchased from www.hearingamestudio.com

domain: game


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After months of debate and setbacks, the legislation resembles the United States Innovation and Competition Act, the original form of the bill intended to boost U.S. competitiveness against China, which cleared the Senate last year but ran aground in the House.
The Senate is scheduled to hold a cloture vote Monday on the new legislation. If it wins the 60 votes needed to clear that bar, it would move on to a final vote by Tuesday or Wednesday. Debate would then move to the House.
Much of the $52 billion would go to chip manufacturers to incentivize construction of domestic factories to produce the components, which are the brains that power all modern electronics.
Global shortages of the tiny components have hobbled all types of manufacturing, forcing automakers to cut production and driving up prices for cars and other goods.
Countries around the world have been scrambling to increase production of the components by offering manufacturers subsidies to build factories, which cost billions of dollars to construct.
The bill also includes about $100 billion in authorizations over five years for programs including expanding the National Science Foundation’s work and establishing regional technology hubs to support start-ups in areas of the country that haven’t traditionally drawn big funding for tech.
The NSF would receive funds for a new technology directorate that would help turn basic research breakthroughs into real-world applications in fields such as artificial intelligence and quantum computing.
“Our universities are very structured around winning NSF grants and publishing. They’ve been less focused on actually patenting,” Sen. Maria Cantwell (D-Wash.), chair of the Senate Committee on Commerce, Science, and Transportation, told The Washington Post. The new funding would aim to help the United States translate its science into applications and domestic manufacturing faster, she said.
Chip manufacturing giants including Intel and TSMC have already said they are counting on receiving some of the U.S. semiconductor subsidies to help finance factory construction projects in Ohio and Arizona. GlobalFoundries, another big chip producer, also hopes for some of the funding to support a factory expansion in Upstate New York.
Three months, 700 steps: Why it takes so long to produce a computer chip
Last week, Minnesota-based chipmaker SkyWater Technology and Purdue University said they intend to win part of the funding to help finance a new $1.8 billion factory and research facility next to the university in West Lafayette, Ind.
In an interview, SkyWater chief executive Thomas Sonderman said the rough plan is for federal and Indiana state funding to pay for two-thirds of the factory, with the rest coming from SkyWater and its chip customers.
The facility would most likely make chips for the auto industry, medical device manufacturers, aerospace customers and the Department of Defense, he said.
Announcing the plan at an event last week, Purdue President Mitch Daniel said the project would make the university “a more vibrant and attractive environment so that the brightest minds in the world will want to come and study and teach and research and live here.”
IBM, the State University of New York at Albany and other partners are also lobbying for funding to establish a semiconductor research center in Albany. Senate Majority Leader Charles E. Schumer is backing that effort.
This week, IBM is planning to fly nearly 60 senior executives to Washington, D.C., to push members of Congress to pass the legislation, spokesman Sean Higgins said Friday.
“Congress has a once in a generation opportunity to reinvigorate U.S. leadership and innovation in a critical field of technology while creating good paying tech jobs nationwide,” Mukesh Khare, vice president of hybrid cloud at IBM Research, said in a statement.

domain: news


A man was arrested for allegedly murdering a single mother and dismembering her body in the Shizuoka prefecture of Japan.
Police discovered the dismembered body of Ayumi Ito, 33, in the home of Yuki Tsuchiya, a 31-year-old married man with whom Ito allegedly had an affair.
Ito’s body parts were found on the balcony of Tsuchiya’s home and in his car.
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According to local reports, Tsuchiya was arrested on Feb. 23 and has since confessed to dismembering Ito’s body in his home.
He reportedly told investigators that he hit Ito on the head with a blunt object in her car and strangled her with a cord.
The crime is believed to have been committed on Feb. 21, when Ito drove to Tsuchiya and had an argument.
Neighbors reportedly heard “rattling and banging” noises coming from Tsuchiya’s home in Numazu, Shizuoka, where he lives with his elderly father, his wife and their two children.
Ito lived in Iwata, which is about a two-hour drive from Numazu. Her car was found in a carpark about 280 meters away from Tsuchiya’s home.
Police believe Ito and Tsuchiya met in 2022 as members of a committee that contributed to the development of Shizuoka prefecture.


Stanford’s SLAC National Accelerator Laboratory has recently announced upgrades to the X-ray free-electron laser (XFEL) component of the Linac Coherent Light Source-II (LCLS-II), making it one of the most powerful lasers in the world. This milestone achievement comes after over 13 years of work.
The XFEL of the LCLS-II is like a massive microscope that generates extremely bright X-ray light pulses. These pulses can capture the behaviors of electrons, atoms, and molecules on their natural timescales. What makes LCLS-II stand out is its capability to provide a million X-ray pulses per second, which is about 8,000 times more frequent than its predecessor.
The upgrades to LCLS-II’s XFEL rely on a state-of-the-art superconducting accelerator with 37 cryogenic modules that cool the environment to an astonishing -456°F, even colder than outer space. This upgraded laser will enable scientists to study quantum materials’ interactions in unprecedented detail.
SLAC’s announcement highlights the importance of understanding the properties of quantum materials, which often exhibit counter-intuitive characteristics. Through studying these materials, researchers hope to advance technology in various areas, such as ultrafast data processing, more energy-efficient devices, and even quantum computers.
In addition to its applications in technology, LCLS-II’s upgraded XFEL will also shed light on biological systems. Researchers will be able to study the intricate dance of proteins and the machinery of photosynthesis with unprecedented accuracy.
The upgrades to LCLS-II have been a long time coming, and this achievement showcases the culmination of years of dedicated work. With its enhanced capabilities, this powerful X-ray laser will provide invaluable insights into the atomic world and pave the way for future scientific discoveries.
– X-ray free-electron laser (XFEL): A laser that generates extremely bright X-ray light pulses used to study the behaviors of electrons, atoms, and molecules on a microscopic level.
– Stanford’s SLAC National Accelerator Laboratory


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ACT health authorities have identified three detainees and one corrections officer as contacts of a positive COVID case that was detected upon arriving at Alexander Maconochie Centre.
Health authorities say police officers and Watch House staff have also been identified as contacts, but neither ACT Health nor ACT Policing specified the number on Sunday.
The Alexander Maconochie Centre will exit a lockdown it imposed in response to the positive case, however other COVID restrictions will remain in place.
Corrective Services Acting Commissioner Ray Johnson said the detainee who tested positive for the coronavirus had passed through the ACT's court cell complex, but had appeared in court via video link.
The person who tested positive was arrested by ACT police on Thursday. It is understood the person was not tested for COVID at the ACT Watch House.
Mr Johnson said Corrective Services took custody of the person from the ACT Watch House, and had kept them as far from other detainees as possible in the court cell complex. The detainee was transported from the cell complex with other detainees, who are now in isolation as a result of that contact.
Mr Johnson said the corrections officer identified as a casual contact of the detainee had been wearing personal protective equipment. Acting Commissioner Johnson said the detainee, who was tested for COVID-19 upon arriving at the Alexander Maconochie Centre, had been isolated since arriving. The positive case had not had contact with anyone who was not wearing protective equipment at the facility.
"So at this point, the facility was locked down yesterday, to give us a chance with [ACT] Health to work through the processes to make sure that we didn't have a further spread, and that we dealt with anyone who'd been in contact," the acting commissioner said.
On advice from ACT Health, the centre would exit its lockdown but retain pre-existing COVID restrictions, he said.
The court cell complex has been deep cleaned.
Acting Commissioner Johnson said all detainees admitted to the Alexander Maconochie Centre were tested and isolated until at least the first test result was received.
Seventy-four per cent of detainees in the centre have received their first vaccination dose, and 55 per cent have received their second dose. ACT chief health officer Kerryn Coleman said the detainee who tested positive for COVID was comfortable and being isolated on site.
An ACT Policing spokesperson said it asked anyone being transferred to the Watch House questions to determine the most appropriate health and safety response: "This may include if a person is symptomatic, has travelled to a hot spot area in the past 14 days or is a close contact of someone who has tested positive for COVID-19."
Our coverage of the health and safety aspects of this outbreak of COVID-19 in the ACT and the lockdown is free for anyone to access. However, we depend on subscription revenue to support our journalism. If you are able, please subscribe here. If you are already a subscriber, thank you for your support. You can also sign up for our newsletters for regular updates.
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Thumper's Thoughts On Porting, Valve Size & Head Flow
Performance is the name of the game!
ALL engine types are welcome... MCS or 'Just-a-Cooper'!
Why buy? Modify! Thinking of needing more power? Thinking of upgrading your Head?
Porting cylinder heads has been the way to more power since there were engines!
It has shown that MOST heads, aftermarket or stock, WILL increase power potential when massaged, ported, and a performance valve job added!! If your head is an "out of the box unit", the power output can be increased with port work! How much power? Anywhere from 18 to 35 WHP on the MINI S with STOCK Tune and ECU settings like most of us have. Or 58 to 65 WHP with ECU Tune and our stock size valve Head.(TPR1)|
- SO, after making all those mods, do you feel you still could use more power?
- Don’t want to purchase a “Racing Head” when you don’t race?
- Want more power for the aggressive drives and weekend track day, and don’t want to sacrifice most of the low to mid-range power for the daily drives to work?
- Want better MPG for the freeway drives?
- Just want more power?
I get lots of inquiries about the "valve size" in the Thumper Ported Heads... I have to answer that question this way:
The Flow Number is the amount of air the ports will flow, at a certain cam or valve lift. The larger the Flow Numbers, the more RPM is needed to get the power from the heads. That upper RPM will hurt the lower torque numbers and throttle response, for the daily commute and drives in traffic when off boost!
Two things make a good head! Flow volume AND velocity! The velocity of the air is what fills the chambers, which allows the engine to build power. The faster the air speed, the quicker the power is made! And this is where the low to mid range power is critical. The flow volume will allow power through the mid to top end.
There are a number of ways to build flow. The first is to port, as you know. The second is to install larger valves (+ 1.0mm or +1.8mm), which is also good. However, if the ports and valve size are too big air will become "lazy" or slow moving, which causes slow, sluggish low speed response and loss of good MPG!
The way to increase the air flow is to run a higher engine RPM, to build up the flow speed (velocity). Try this... an MCS with big-valve head! Runs killer on the top end. But... under 4000-4500 rpm… it is a dog.Lazy air movement at the lower RPMs kill the daily drive fun as the low to mid-range power is sacrificed for the higher RPM power needed for track racing.
Most of my heads are on cars that are used with dual purpose (spirited street and occasional track.) I want crisp, fast, throttle response, snap off the line on a mildly modified engine (pulley, CAI and exhaust.) I want a head that will pull hard and strong to 6800-7200 rpm! So... I want VELOCITY and Flow Numbers! I do this by keeping the stock valve size and doing a 5-angle performance valve job with a “flow cut” on the valve! The 5 angles act as a boost to the air flow as the valve just leaves the seat, and also when the valve is just about closed! This increased low-lift flow allows the air to fill the chamber faster! The faster the chamber is filled the faster and more power the engine will make! Then when coupled with my PORT/throat/bowl work the Head will keep making power till you lift off the gas!
We do also make a Thumper Performance Upgrades ( TPR2 and TPR2r ) for those that want to Track Race with the RPM levels in the 4500-8000 rpm ranges. As now the rage seems to TURBO the r53, we now even offer a Ported BVH with the Inconel Exhaust valves. No one head fits all applications.
(Note: for all other Cylinder Head modification SEE: www.thumperoforangepark.com )
Thumper Performance Ported Heads are made to your application, NO "one size fits all!"
We do the head for the N/A Cooper as well as the Supercharged!


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Sony PlayStation 2 (2000)
Sony’s PS2 kicked off the decade, launching in March of 2000 in Japan. From then on, it proceeded to flatten the competition, selling more than 140 million units in the last decade. The PS2 didn’t just provide an awesome gaming experience; it served as many people’s first DVD player and has remained a pop culture icon since.
Nikon D1 (2000)
The Nikon D1 was the first Digital SLR to really replicate film; destroyed Kodak’s then-undisputed reign over the professional market and got us all fixated with mega-pixels for a while. With the advent of the DSLR, and the popularity of point and shoot digital cameras, the days of print film are just about over—except maybe for hobbyists and the nostalgic-types. Yes, the D1 was the game changer for both photography professionals and enthusiasts.
USB thumb drives (2000)
The flash (or USB) drive is undoubtedly, one of the most underrated technologies of the past decade. It ended the dominion of the floppies and recordable CDs and found a way to the pocket of most students and business professionals. Suddenly, storing and saving your projects and research work quickly was no longer a cause for concern.
Apple iPod (2001)
There probably aren’t any other gadgets in the past decade that has changed the technology and music industries as drastically as the venerable iPod. It also dealt a huge blow to the music industry, made music even more portable and changed the way the world listened to music.
2001 – AbioCor Artificial Heart
In July 2001, the medical world changed forever when doctors implanted the Abiocor artificial heart in a patient for the very first time. The patient, a 59-year-old grandfather and retired librarian, was suffering from end stage heart failure. A product of three decades of research, development and testing, the Abiocor changed the game because it provided the first self-contained replacement heart.
2002 – Wireless Headset
While the invention of the year in 2001 changed the world, we certainly hope that none of our InventHelp Newsletter readers ever need to use it. The winner in 2002 is another story – many of you may be chatting on your headsets now! The now-ubiquitous wireless headset, or Bluetooth as many now call it, is nearly as common as a cell phone these days. The drawback of this invention? Passersby may think you’re having a conversation with the voices in your head rather than a person on the line!
Research in Motion Blackberry (2002)
The original Blackberry was stylish and elegant even back then, and with it, you could send or receive email, chat with your clients or friends, open and check the attachments and surf the net at a good speed. The Blackberry set the benchmark for future smartphones, including the iPhone many years later, on how we multi-task and connect while on the go.
2003 – The 99¢ Solution
This one isn’t technically an “invention,” going by the bread-and-butter, tangible definition. What Steve Jobs and Apple did is invent a new lifestyle solution and a new mindset for millions of music fans. It’s shockingly simple in its pure brilliance – charge buyers less than a buck for a song and let them play it whenever they like, as long as it’s on an Apple iPod. You can thank this invention for making Walkmans more passé than bell-bottoms.
2004 – SpaceShipOne
The Space Race between the Soviet Union and the United States made children everywhere want to grow up to be astronauts. The sad reality for budding cosmonauts is that their dreams were never meant to be; after reaching the moon in 1969 the U.S. shifted focus to unmanned probes and shuttles. SpaceShipOne emerged as an outlet for Earthlings with stellar aspirations. Today, SpaceShipTwo – the newest commercial space vehicle – is happy to propel you into space for a mere $200,000!
Motorola Razr V3 (2004)
The ultra-slim MotoRazr came with a flip-open lid and became a rage overnight. It made big guys and girls go weak in the knees. It was also a dream phone for kids and teenagers. Sure, it may not be fully loaded with features but it set the trend for how phones shouldlook.
2005 – Tweel
In 2005 the world met Michelin’s Tweel, which inspired to rid the world of flat tires. The Tweel features a shock-absorbing rubber tread band that distributes energy to a series of thin, polyurethane spokes. And it’s airless, which means no middle-of-the-night flat tire changes. The Tweel is still too noisy for regular passenger vehicles – watch for it in 2020, when we’re counting down the best inventions of NEXT decade!
High-Definition LCD Televisions (2005)
Forget about 3D and LED technology. Without the birth of high-definition (HD) LCD, 3D and LED technology wouldn’t even have caught on. HD Technology provides a crisp, clear picture for viewers. It’s sometimes difficult to tell how we will ever get along without it. Try watching a show on an HD set, and then watch the same programme on standard definition (SD) television. The difference is astounding. It also opened the floodgates for Blu-ray and high-def videogame content.
Nintendo Wii (2005)
When everyone else was digging deeper with elaborate games and sharp high-definition graphics, Nintendo decided to go with game play. Smart move. The Wii has sold more than 57 million units as of end 2010. Of equal importance, it sent rivals Microsoft and Sony scrambling to come up with motion based gaming systems of their own. Without the Wii, the Kinect and the PS Move may not even have surfaced at all.
2006 – YouTube
We’re guessing you’ve heard of this one. The invention that transformed regular computer users into stars was born in 2005 and earned TIME Magazine’s distinction as Best Invention just a year later.
2007 – iPhone
Yes, you’ve heard of this one, too. Perhaps the most exciting side effect of the world’s most intelligent phone has been watching the rest of the cell phone world scramble to catch up. When great phone inventions compete, we all win.
Rock Band (2007)
The return of the karaoke craze into our living rooms is surely attributed to the insane success of the videogame Rock Band, where players use guitar-shaped controllers, drums and microphone and play out a full band. The impact of Rock Band (and its rival Guitar Hero) on the music industry has caused music publishers to re-evaluate their approach to music licensing and their relationship with the video game industry. It also brought about a different perception to how mainstream consumers view videogames these days.
2008 – The Retail DNA Test
Just how much (or how little) do our genes define us? What do they mean for our health and our future? TIME ignited controversy in 2009 by choosing consumer gene-testing company 23andMe as its Invention of the Year 2008. For more on how this invention works, visit our InventHelp Newsletter article on 23andMe, where we explored this topic when it made the news.
2009 – NASA’s Ares Rockets
That brings us to this year’s big winner, which TIME writer Jeffery Kluger calls, “the best and smartest and coolest thing built in 2009.” To invent a rocket is extraordinary; to invent an extraordinary rocket is… well, they haven’t invented a word for that yet! The Ares 1, which successfully completed its first unmanned flight this October, is the largest thing that’s been launched into space since the 1970s. This rocket could be the machine that takes astronauts to Mars and beyond, and a future in orbit could be a reality for a new batch of aspiring astronauts.
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Disability & Sustainable Development Goals
During the 2016 International Symposium: Disability in the SDGs: Forming Alliances and Building Evidence for the 2030 Agenda, held in London, UK
Disability & Assistive Technologys
What is assistive technology? Assistive technology (AT) includes a wide range of technology products (often called devices or aids) that are used to improve mobility,
Data and Statistics on Disability in Developing Countries
The authors of this report, funded by DFID, collaborated with SAFOD and National DPO leadership, to produce disability statistics internationally and in the Southern African Region.
Nairobi Declaration-Post 2015 Development Agenda
Communiqué issued at the “Inclusive Post-2015 development agenda and UN CRPD in Africa’ Conference organized by the IDA in Nairobi, Kenya, from 6 to 8 of March 2014.
Status of Disability Rights in Southern Africa
Status of Disability Rights in Southern Africa was prepared by Hermien Kotze and funded jointly by the OSF for South Africa, OSISA, and the OSF Disability Rights Initiative.
Discussion paper: ECD and Disability
Published by WHO and UNICEF to provide an overview of issues pertaining to ECD and disability and identify sustainable strategies to guarantee rights of CWDs.

domain: sociology


Addressing water/humidity problems should be a top homeowner priority. That's because moisture supports the growth of mold and mildew. This can make family members sick and cause extensive damage to your house if ignored (read: Protecting Indoor Air Quality at Home). So the purpose of a bathroom fan is to remove the moisture from the air after you take a shower or bath … so don't forget to turn it on!
When Do Homeowners Need a New Fan?
- When your bathrooms don't have an exhaust fan. For many years, it was assumed that if a bathroom had a window, it didn't need a fan. You could open the window to remove the moisture. We've learned most people won't do this because it's too cold outdoors or the air conditioning is running.
- Your bathroom fan is too noisy, a common problem with inexpensive fans. Either the fan(s) were installed by builders focused on minimizing costs or a previous homeowner didn't consider this when buying a replacement fan.
- When running properly, your bathroom fan should hold a sheet of toilet paper tightly.Your bathroom fan has stopped working. This isn't unusual as the expected lifetime of exhaust fans is 10 years. And when you compare the time and materials to try and repair these fans, the low cost of a replacement makes this a more practical solution.
- With bathroom remodels, you might want to upgrade to a more contemporary fan and one that includes lighting.
How Big a Bathroom Fan Do You Need?
The size of the fan matters and we're not talking about the physical size. The bigger your bathroom, the more “cubic feet per minute (CFM)” the fan needs to circulate. The recommendation is a fan large enough for eight air exchanges per hour. For the average bathroom that's 8 ft x 10 ft with 8 foot ceilings, that means you'll need an 80 CFM fan like Panasonic's WhisperCeiling 80 CFM shown here.
When installing a vent fan, make sure there’s at least a 1/2″ gap under the bathroom door to allow fresh air to enter the room when the fan is running. Run the fan for 15 to 20 minutes after showering or bathing to expel all the excess moisture.
If you're uncomfortable calculating the size of your bathroom, here are the minimum bathroom exhaust fan ventilation requirements from the Home Ventilating Institute. Other things to consider are ceiling heights over 8 ft and toilets in separate room … may require addition CFMs.
|Minimum Ventilation (CFM) Required
|50 sq ft
|50 to 100 sq ft
|1 CFM per sq ft
|Add up CFM requirements for fixtures:
How to Find a Quiet Fan
Have you owned a house where you didn't turn on the bathroom fan because it was too noisy? Even I've done that until it became annoying enough to replace the fans, even though they were brand new. Bathroom fan sound levels are measured using sones, where the lower the number, the quieter the fan. To put these fans in perspective:
|Noise Level (Sones)
|Typical office noise
|Quiet fans rated 1.0/less sones
Other Features Available with Bathroom Fans
Most of these fans aren't very noticeable when installed, appearing as another vent in the ceiling. There are other options you can get with your fan. These include decorative lighting, heating elements, timers and even a humidistat to automatically turn the exhaust fan on when the humidity reaches a certain level.
Bathroom Fan Installation Tips
There are lots of great articles and videos that offer step-by-step installation tips. Here are some of the best ones we've found, along with advice on the most common problems you'll find related to poor installation techniques.
- Problem – The bathroom fan is usually placed in the center of the room which is wrong.
- Solution – The fan should be located over the major source of humidity, either the shower or bathtub.
- Problem – Too often, the fan is not properly vented to the outside. Most often builders only run the vent up to the attic where the moisture will damage the insulation.
- Solution – Proper venting of any exhaust fan should follow the straightest path to the outside. Elbows restrict the flow of air and if the vent isn't insulated, condensation can form (great illustration of a bathroom fan venting through the roof).
- Problem – When replacing a small fan with a larger one, you may need a larger hole or more support. We often ran into this problem with my handyman business (lots of older homes in southern New Hampshire), when the customer bought the new fan.
- Solution – Know the size of the fan's opening when shopping, whether it's hard-wired or using an outlet in the ceiling and whether it's supported on one or two ceiling joists. Be prepared to make adjustments to support the new fan.
Helpful resources I found while researching this article:
- How to Clean a Bathroom Exhaust Fan
- Troubleshooting Your Bathroom Exhaust Fan
- How to Repair a Bathroom Fan (video)
- How to Replace a Bathroom Fan (video) … but it doesn't cover venting through the roof so I'm still looking for a good video on this topic.


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BAKU, Azerbaijan, Nov.5
By Ilhama Isabalayeva – Trend:
Azerbaijan’s Amelioration and Water Management OJSC disclosed the number of water farm and land reclamation facilities under occupation, Trend reports on Nov.5 citing the company.
According to the company, in the occupied territories, there were nine reservoirs (Sugovushan settlement where the reservoir is located had already been liberated) and seven basins. The length of the irrigation networks on the lands occupied by Armenia was 6,426 km, the number of waterworks - two, the length of the collector and drainage network - 330 km, the hydraulic structures - 8,003 km, the number of pumping stations - 88, and sub-artesian wells - 1,429.
Some 125,800 hectares of irrigated land in Azerbaijan were remaining under the occupation.
The company noted that special commissions will be created to more exactly determine the number of water and land reclamation facilities in the liberated territories. As a result of the investigation carried out by these commissions, the areas fit for use will be identified.
The commissioning of those facilities after the liberation of the occupied lands will ensure uninterrupted water supply to the territory where there are difficulties with this, will contribute to the expansion of irrigated land, increase agricultural yields and restore the ecological balance. Ultimately, all this will contribute to higher yields throughout Azerbaijan, summed up the company.
Armenian Armed Forces launched a large-scale military attack on positions of the Azerbaijani army on the front line, using large-caliber weapons, mortars, and artillery on Sept. 27.
Azerbaijan responded with a counter-offensive along the entire front. As a result of retaliation, Azerbaijani troops liberated a number of territories previously occupied by Armenia, as well as take important, strategic heights under control.
The fighting continued into October 2020, in the early days of which Armenia has launched missile attacks on Azerbaijani cities of Ganja, Mingachevir, Khizi as well as Absheron district.
Despite the fact that so far the parties have reached an agreement on a humanitarian ceasefire three times, Armenia continues to violate this agreement.
The conflict between the two South Caucasus countries began in 1988 when Armenia made territorial claims against Azerbaijan. As a result of the ensuing war, the Armenian Armed Forces occupied 20 percent of Azerbaijan, including the Nagorno-Karabakh region and seven surrounding districts.
The 1994 ceasefire agreement was followed by peace negotiations. Armenia has not yet implemented four UN Security Council resolutions on the withdrawal of its armed forces from Nagorno Karabakh and the surrounding districts.


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KARACHI: Jamaat-e-Islami (JI) Karachi Amir Engr. Hafiz Naeem-ur-Rehman has demanded of the government to complete the mass transit project, initiated by former city mayor Nematullah Khan, so as to mitigate the miseries of commuters in Karachi.
In a statement on Monday, he said that Karachi is the only mega city with population of more than 20 million individuals but without a mass transit system.
He expressed his grave concern over the situation of transport in the city that has become worst from bad after the recent ban on QinQi rickshaws.
He was of the view that without provision of alternative, the ban has further fuelled the already burning issue of transportation in the city.
The JI leader recalled that Nematullah Khan had introduced green busses under the mass transit project, which were illogically replaced with CNG rickshaws under mysterious circumstances.
He stressed the need to re-evaluate the transport requirements of the city and introduce a mass transit system accordingly.
He further said that CNG rickshaws should be restored on limited basis to small routes with strict regulations and a proper strategy should be devise to cater the needs of the mega city on long term basis.


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There is no question that the past year has changed and challenged the Irish fashion industry and all around the country designers are finding new and stylish ways to meet the sartorial needs of their clients, Fee G included.
Fee G has long been a staple on the Irish fashion scene for occasion wear that is synonymous with elegance and ease, and recent collections have seen Fiona Heaney explore daywear and separates with a more relaxed flair.
Today's top videos
The Irish designer has released her first athleisure collection, offering a selection of chic hoodies and jumpers, and there is nothing basic about these knits.
Loaded with colour and full of feminine details, the DAY x Fee G athleisure line is all about bringing a touch of luxury to your everyday with pieces that you will want to lounge about in and be seen wearing out and about equally.
Intricate beading, studded eyelets, string ties adorned with golden threading, these Irish-designed hoodies and jumpers are packed with chic details designed to make a statement.
Colour is a staple of the Irish label and while there are versatile neutrals from ecru and black, there are also soft grey and sky blue hoodies elevated with luminous coral floral embroidery.
One of the most standout pieces from the new collaboration is the embellished crew jumper which is adorned with funky embroideries including eyes.
Who says that your loungewear has to be basic, this would one-up any casual outfit and it comes in two poppy hues, pink and mint green.
Sustainability and conscious production are at the heart of the brand-new offering from Fee G.
The loungewear pieces are made from 100 per cent natural fabrics and there are new organic cottons being trialled for later styles and packaging is 90 per cent biodegradable.
Designed in the brands' studio in Dublin the stylish pieces are manufactured with their partners in Portugal. Some styles have been produced in a small family-run factory in China for their skill of hand beading.
Styles have a relaxed fit for added comfort and run in sizes small to large.
Prices range from about €98 to €137 and you can check out the rest of the collection in the campaign video and gallery below.
The DAY x Fee G athleisure collection is now available to shop over on Fee G's website.

domain: design


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Cameron Boyce - IMDb
Cameron Boyce. Actor: Mrs. Fletcher. Cameron Boyce was an American actor, with Afro-Caribbean and African-American descent. His paternal grandmother Jo Ann Allen was one of the "Clinton Twelve", the first African-Americans to attend an integrated high school in the Southern United States (specifically in Clinton, Tennessee). In 1999, Boyce was born in Los Angeles, California. He was trained as a dancer from an early age. In 2008, he made his debut...

domain: celebrity


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Graham Therapy and Fitness, P.A.
Graham Therapy and Fitness is located in the heart of Bethesda, MD. We are small physical therapy and wellness practice. Our office is situated on Saint Elmo Avenue, making it a commonly frequented spot for physical therapy in Bethesda and the DC Metropolitan area.
Graham Therapy and Fitness was founded by Jennifer Graham in May of 2008 in Rockville, MD and moved to Bethesda in 2012. Since opening in 2008, we have specialized in the treatment and conservative management of scoliosis, kyphosis and spine/posture conditions. Our practice is unique as we specialize in using the classical Schroth Method in tandem with our own scoliosis/kyphosis/posture specific program and methodology. Additional scoliosis and posture methods developed under Jennifer Graham have excelled our results through clinical evolution. We have a highly experienced staff including physical therapists and personal trainers. We also offer specialized treatment services for any pain, injury, or discomfort you may be feeling. Our patients have found high levels of success in our treatment services. Due to our implementation of advanced technology, creative approach, thinking outside the box and evaluating multiple angles that could contribute to a diagnosis and appropriate methods.
We use sophisticated diagnostic methods, such as movement investigation and gait analysis, to help determine which services you will benefit from most. At Graham Therapy and Fitness, our thorough evaluations lead to successful treatment plans for your pain relief, healing, and future injury prevention needs.
At the end of the day, our team is here to provide support to YOU – the patient. Our success is dependent upon your success. And we strive to create a warm, welcoming environment where you can comfortably heal and feel at home.
At Graham Therapy and Fitness, we have one mission helping our patients reach their highest physical potential. Furthermore, we strive to provide the highest degree of specialized care for scoliosis and kyphosis patients and clients. Our treatment plans are aimed toward the achievement of each patient’s goals, taking into account their symptoms, medical history, and any health restrictions they may have. In addition, our treatment plans and methodology provide a non-surgical alternative for scoliosis and kyphosis patients. We look forward to watching each and every one of our patients achieve their goals. With our care and commitment, we know that is possible for anyone who walks through our doors.
If you are in the Bethesda, MD area, or any of the surrounding areas. And you are looking for relief, look no further. Graham Therapy and Fitness is here to help as one of the most favored Bethesda physical therapy practices. Call our office at 301-652-2161 to schedule an appointment with one of our physical therapists today! We will be happy to meet with you. And create a plan for your journey toward health, healing, and pain relief.
Metro Train - Red Line InformationWe are conveniently located within walking distance of the Bethesda Redline Metro stop and also on the Metro bus routes.
Local Bethesda Circulator Bus InformationLocal students and patients or out of town patients/families staying in Bethesda, can take the Bethesda Circulator Bus www.bethesda.org/bethesda/bethesda-circulator to the Jewelry Factory stop and walk only steps away to the building. Download the app for your Apple or Droid phone or tablet by searching "Bethesda Circulator" in the App store. Droid users, code is bup.
Bethesda, MD 20814
Patient Care Hours
Fri – Sun: closed
Personal Training Hours
by appointment only
Office Admin Hours
Mon: 9am – 5pm
Tues: 9am – 5pm
Thurs: 9am – 5pm
Scoliosis, or curvature of the spine, often occurs when children are just entering puberty, which is a stressful enough time without also having to deal with a physical limitation. Physical therapy is very useful for scoliosis patients and treating Scoliosis is our specialty!
The Schroth Method is a specialized treatment method which addresses the scoliosis and kyphosis curvatures through exercises to strengthen or lengthen asymmetrical muscles in a scoliotic body. We are one of the few practices in the world that provide the Schroth Method.
We offer personal training to individuals who have reached their potential in physical therapy and are ready to switch to a more aerobic environment. Each training is customized to your specific needs and goals and delivered by a certified instructor and trainer.
Physical Therapists & Personal Trainers - Bethesda, MD
Meet The Team
Our Bethesda physical therapists are both compassionate and caring, ambitious toward helping our patients reach their highest level of performance with the least possible amount of discomfort. Our dedicated team consists of leading experts in the physical therapy Bethesda area, any of whom would be happy to work with you on whatever you may be struggling with. They will work hard, not only to get to the root of your problems and provide quality treatment for the pain you are currently experiencing, but they will also use their abilities to provide you with injury prevention services for the future.
We Specialize in Scoliosis, Kyphosis, and Posture of Bethesda
Physical Therapy specifically tailored in the evaluation and treatment of scoliosis, kyphosis, and posture can be highly effective in promoting improved postural muscle balance and symmetry, promote curve stabilization, promote improved breathing/ventilation, and improved body mechanics in daily living and also sport/extracurricular specific activities. The techniques utilized at Graham Therapy and Fitness help to provide a non-surgical conservative management option for scoliosis and kyphosis patients.
We Specialize in Relieving the Pain of Bethesda
Physical therapy can be highly effective in relieving pain by providing a type of treatment you may need when your pain makes it hard to move around and do everyday tasks. Our treatments help you move better and may relieve your pain. They also help improve or restore your physical function and your fitness level. The goal of Graham Therapy and Fitness is to make your daily tasks and activities easier. For example, we may help you with walking, going up stairs, or getting in and out of bed. In addition, physical therapy often provides the best treatment for a variety of different pains, not only providing relief, but also teaching you techniques to prevent re-injury and avoid pain in the future.
What Bethesda Thinks About Graham Therapy & Fitness
Jennifer is a fantastic physical therapist. For years, I’ve had shoulder, hip and foot pain—all on my right side. Well, what do you know? I have mild scoliosis that’s never been diagnosed and I’m 43! Jennifer has been incredibly helpful in treatment and also teaching me the right way to stand and walk for my condition. I would highly recommend her to anyone—and best of all, she’s a lot of fun!
I came to Graham after attempting correction of my Kyphosis with yoga and another PT. My acupuncturist had said that PT wouldn’t help the condition, and the prior PT I consulted, said that there was a chance that I could obtain a 20% correction with their organization.
I worked with Jennifer over a 4 month period, and obtained a correction of over 50%. I no longer engage in yoga, acupuncture or PT, and after 1 year, I remain free of pain, provided I continue some of the exercises she taught me.

domain: medical


Includes one each of our 10″, 8″, and 6″ AR550 gong targets in 1/2″ thickenss , A-frame conduit holders, and three of our AR500 hook and strap target hangers. Each ar550 target has two shooting options. Leave the strap lock down and it acts more like popper system. Leave the strap lock open and the targets swing in a pend-elem action when stuck. This system is a blast to CQB shoot with your .223. Additional AR550 targets, chains, conduit legs, straps and bolts are not included with this item unless otherwise stated.
Shooters and spectators must always wear proper eye and hearing protection. Shooting targets with full metal jacket, steel core, slugs or rounds traveling over 3000 fps may cause minor dents or craters. (remember you are shooting steel with steel). Never shoot armor piercing or steel bird shot at any steel target. Using a deformed or damaged target can lead to injury. Minimum distances are as follows: 10 yards for pistols and 100 yards for rifles. Please review our caliber chart for minimum distances coordinating to your caliber. Buyer assumes all responsibility for the use and misuse of the purchased steel targets.


text: The objective of the project we are presenting is to renovate the basement of the building of Via Bellezza 16/a, so that its spaces can be used again, and the city can be given a part of its historical memory back. In particular, the large hall, once restored, can become a space open to the city, and transmit the value of Italian cinema, because it will become an active laboratory in which the possibility of experimenting, seeing, implementing and enquiring will be offered. From cinema to theatre, an artistic performance will become a place of reference in Milan, the place where to meet to experiment and realize artistic products. The large room will become a multipurpose space, equipped for exhibitions, lectures, film screenings and theater performances. It will also be designed to be used for activities related to audio-video production, as well as photography exhibitions, musical events and concerts. As soon as it is in function, we will involve the schools and universities of the metropolitan city, especially the neighbouring ones, the cultural associations in the area, to implement together a participatory planning, which can really give an answer to the needs and dreams of the community.

domain: artistic


Sounds of the Global Breakthrough Festival
Spurred on by the resounding success of the inaugural Global Breakthrough Festival held in Cape Town, South Africa, in 2007, organizers, DJs and party-goers are gearing up to do it all again – but even bigger and better than before. From 27 February to 2 March 2008 Global Breakthrough teams up with Miller Genuine Draft for five days of partying in some of Cape Town’s prime venues.
South African clubbers can grab hold of the opportunity to party to the sounds of local DJs along with some of the most sought after international DJs, covering a diverse spectrum of genres. International clubbers are invited to enjoy the South African clubbing scene in one of the most beautiful cities on the African continent.
The five-day Global Breakthrough Festival will feature one of the hottest DJs currently on the international clubbing scene, Chilean born Luciano. He is considered to be chiefly responsible for re-shaping the Latin American music scene with his DJ sets, which are a hybrid of minimal, techno and house. Known as Âme, producers Frank Wiedemann and Kristian Beyer who shot to fame during 2007 with the club single “Rej” – French for “Soul” – will be a highlight on the 2008 program. From Bodensee in southern Germany, Henrik Schwarz has been widely acclaimed for his dance mixes and is ready to entertain the crowds at the Global Breakthrough Festival.
Snow Patrol, from Glasgow in Scotland, have become one of the biggest selling bands in the world, with hits including “Chasing Cars”, “Run” and the soundtrack to Spiderman 3, “Signal Fire”. Tom Simpson (keyboard) and Gary Lightbody (Vocals) of Snow Patrol are taking a break from touring – and from the cold Northern Hemisphere winter – to enjoy the Global Breakthrough Festival in sunny South Africa. On 1 March the duo will be performing their unique brand of music on top of the renowned Cape Town landmark, Signal Hill, a venue which offers an incredible 360 degree view of the Atlantic Ocean, Cape Town and Robben Island.
Other Cape Town venues for the Global Breakthrough Festival include Karma in Camps Bay, Mzolis in Guguletu, the Helicopter Hangar at the V & A Waterfront, The West Coast Ostrich Ranch and Baraza in Camps Bay. Fringe events will be hosted in Gauteng at The Miller Warehouse in Centurion and the Godfrey Moloi Mansion in Soweto. South African DJs include Oskido, Rick Hunter, Killer Robot and Digital Rockit.
Clubbers visiting Cape Town and Gauteng for the Global Breakthrough Festival will find that there are many compelling reasons to stay and enjoy the sunshine and hospitality of this unique country at the southern tip of Africa.


Former Googler Sarah Cooper describes her journey as she moved from Tech to Comedy. Today, Sarah is a successful writer and comedian, with a popular blog https://thecooperreview.com/ that gets >100,000 readers per month. She regularly performs as a standup comic, and has authored multiple books inlcuding "100 Tricks To Appear Smart In Meetings" - https://www.amazon.com/100-Tricks-Appear-Smart-Meetings/dp/1449476058
Some of the areas that Sarah touches upon in this episode include:
1. How Sarah kept working on her writing and her comedy, while she was doing her day job
2. What convinced Sarah to leave her job at Googler
3. The challenges she faced after quitting her job
4. Some things that Sarah thinks helped her get through this transition phase
5. Sarah's advice for anyone contemplating a similar career change
Thank you for listening!!
Follow the show on Twitter @LED_Curator
Like us on FaceBook at www.facebook.com/learneducatediscover/
Email us at hello@learneducatediscover. We will reply!!
Subscribe to the show on iTunes itunes.apple.com/us/podcast/learn…ver/id1049159321


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In Europe, the actual roulette wheel has become a symbol with regard to casinos. You can hardly come across any game house or casino in European cities where the roulette wheel is not displayed. If you want to try the game in your own home casino, you can do so by using a fantastic roulette wheel. Below are some internet sites where you can find casino quality roulette wheel that you can buy.
Amazon.com – Roulette Wheel available for purchase
Amazon is an online shop where you can find just about anything you need for your house. Amongst their extensive listing of products are roulette wheel available for purchase and a few home gambling tables intended for poker, blackjack, craps, and roulette. This website features a 10” roulette wheel for sale complete with a felt layout, chips, rake, steel ball, and also blackjack for your house gambling needs. You can even find a 12” and a 16” roulette wheel available for sale in addition to roulette cases that are violin-shaped and other game sets.
unbeatablesale.com – Roulette Wheel for Sale
Another online shop that has casino wares, unbeatablesale.com has roulette wheel for sale and other game supplies as well. Their particular roulette wheel for sale is sold at sale prices and also sizes vary from 18” through 30”. They likewise have a good roulette wheel for sale that includes components such as the win marker and chips. This 18” roulette wheel for sale at unbeatablesale.com is made from thick bakelite. The actual wheel is well-balanced using steel linear bearing. The 30” roulette wheel available at this same site is definitely the most expensive wheel item they have got. It is made of high-quality Maple and Mahogany wood with stainless steel rims.
eBuy.com – Roulette Wheel for Sale
eBuy offers an 18” roulette wheel available for purchase. This particular roulette wheel for sale follows the American adaptation where there are 2 zeros, 0 and 00. When you get this roulette wheel for sale, you also acquire TWO roulette balls totally free. This wheel is actually skillfully balanced and comes equipped with a steel linear bearing.
Buy.com – Roulette Wheel for Sale
Buy.com dedicates a portion of their own website on game room items as well as accessories. Among the products showcased on Buy.com’s Game Room Store section would be the roulette wheel for sale. The website offers a 19” exotic wood roulette wheel that can be purchased together with precision bearings. Another item is the 18” abs roulette wheel for sale and still with precision bearings intended for better stability. The actual precision bearing characteristic of these wheels ensure that there is no wheel bias and that games really are honest.

domain: hobby


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From USD 140
Join us on a journey into the Historic Barceló Museum in San Pedro de Macorís, where you can look behind the scenes of one of the most important constituent factors of the Dominican Republic: Barceló Rum. Take part in a tour through the various processes of the manufacturing of rum: Distillery, refining, rum cellars and packaging. You will also visit an exhibition which shows the history of rum and the Barceló family. The exhibition is located in a museum, which was built in the shape of a rum barrel. For the grand finale a rum tasting awaits you. Afterwards visit the interesting cave system "Cuevas de las Maravillas" with underground rivers and stalactite caves. It is the largest developed stalactite cavern in the Dominican Republic and displays several hundred pictographs created by the native Taino Indians.

domain: history


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The producer/singer duo of Amamiya Miku and Paseli-chan are one of the most active groups on the scene, playing tons of live shows and finding time for the occasional CD-R release to keep their flow of creative output fresh-faced and continuously evolving. Their group, NaNoMoRaL still remain one of the great stand-outs of a saturated scene, because they pursue their own vision and eskew the easier paths to more conventional success as an idol unit. This gamble pays off for them, at least on an artistic level, as they consistently make excellent, powerful music with lots of heart and courage!
「 唖然呆然 」
— NaNoMoRaL -ナノモラル- 11/11(月)渋谷WWWワンマン (@NaNoMoRaL_info) August 11, 2019
The CD-R is a single song “Donen Shizuru” (I hope I got that right.) and it’s very much a continuation of one of the more unique and distinctive sounds to be found in idol circles. And as an extra treat, Amamiya stars in a low-key DIY MV to share the song with the world at large…
I wish more groups would get that you can totally make a proper MV with not anything more than a basic camera (or even a phone) and a little editing magic without breaking the bank on a big but hollow video epic. You just need to get people to listen to the music, and let the visuals compliment the audio, not compete with it for your attention. Of course, it helps if you have the music pull it off, which NaNoMoaL does.
Another interesting thing with this song is while Paseli-chan frequently lends vocals to the group’s songs, this particular tune has a little bit more of his voice than previous songs. I really like the duality of this arrangement. And of course Amamiya Miku’s voice is the star as always, as she sings like her heart depends on it, selling each line with a sincere conviction and emotion. I can’t imagine she ever does anything half-hearted.
Currently this CD-R is a live-show only merch item, but considering the rate of how they record, I’m hoping there’s an more-widely released EP or even an album around the corner. Seeing how “Nisan ka Tanso” was one of the best things to happen in 2018, they could surprise us with something that’ll be equally acclaimed before this year is over.
— NaNoMoRaL -ナノモラル- 11/11(月)渋谷WWWワンマン (@NaNoMoRaL_info) August 12, 2019


Posted: Jan 20, 2018
Jan.19-BETHANY, W.Va.- The Hiram College swimming & diving team collected their first victory of the season against Bethany (167-109), Friday night. This victory not only marked the first win of the season for the team but also the first-career win for Austin Veltman as a head coach.
Hiram's win was accomplished with a collective effort. The women's 200-yard medley relay opened up the day, scoring 11 points for the Terriers with a first place victory. The relay featured Freshman Nicki Prentler, sophomore Jill Schmidt, junior Sierra Daniels, and freshman Kerrie Romagna.
In the next event, Sophmore Jenna Nelson collected another Hiram win in the 1650-yard freestyle, clocking in at 20:08.87.
Freshman Mallory Best notched two more events for the Terriers winning the 200 (2:23.78), and 50-yard freestyle (28.94).
Hiram won two last women's events with Daniels adding nine points in the 100-yard butterfly (1:13.87), and Romagna locking down a first-place finish in the 100-yard freestyle (1:08.37).
Freshman Brady Gunther kicked off the men's side finishing first in the 200-yard freestyle in 1:59.08. Gunther came back later that night and captured another win in the 100-yard backstroke (58.74).
Senior Jory Gomes followed his lead claiming the top spot in the 200-yard IM (2:19.28), and the 100-yard freestyle (1:02.19).
Junior Reeve Bowling swept the 100-yard butterfly 58.42 and breaststroke 1:06.87, and made a runner-up appearance in the 50-yard freestyle (22.9), adding 22 points for the Terriers.
Junior Michael Barber dominated the 500-yard freestyle, coming in over seven minutes faster than his competition (5:38.04).
The Terriers hit the pool again Saturday, Jan.20 as the women take on Franciscan and Washington and Jefferson in a tri-meet, and the men take on Washington and Jefferson in a dual meet. The meet is scheduled for a 1:00 pm start.


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- 55 guest reviews
"This hotel was very clean with a comfortable bed and large en suite. It is great value for money for an overnight stay. Would stay again, bu..."
"We stayed one night in Jesmond and chose this hotel for its location and for the price. From this location we were just out of all the noisy..."
"Just what needed, double ensuite fair price, comfy bed. Inclusive of parking permit. You could prob walk from here to city centre.... About..."
"It is what it is, cheap and cheerful. The staff were extremely helpful and pleasant, the room lived up to what I was expecting for the price..."
"Ideal for a 1 night stay. Great location...."
About the hotel
Welcome to Jesmond Hotel, a small hotel near Newcastle Upon with a personal touch. Whether for business or pleasure, our central location with its welcoming and relaxed atmosphere is perfect for visitors to Newcastle & Gateshead as well as the wider region. We pride ourselves on excellent customer care, giving individual attention to all of our guests and ensuring a very high standard of service throughout the hotel.
Limited Free Parking is available on first come first serve basis (Permits given on arrival). The hotel accepts no responsibility for parking fines. It is the guest responsibility to display the permit or alternatively to park elsewhere when permits are not available.
Showing Tuesday 2 June 2015 to Wednesday 3 June 2015Change Search
We currently have no rooms available for this hotel that match your search criteria. Try changing your search or select an alternative hotel.
- Hotel Non-Smoking Throughout, Disabled Facilities
- Hotel services
- 24 Hour Reception, Limited Hours Room Service, Limited room service for hot food, Laundry/Valet Service, Wake Up Call Available
- Family friendly
- Cots available
- Wi-Fi Available, Wi-Fi Available In Public Areas, Wi-Fi Available In Rooms
- In room entertainment
- Video/DVD Player, TV, CD Player, [Channels] News, [Channels] Music, [Channels] Childrens, Radio
- In room facilities
- Tea/Coffee making facilities in each room, Hairdryer in each room, Telephone In Each Room
- Porter, Ground floor bedrooms
- Car Parking Available Offsite
- Disabled Access Public Areas, Disabled Access Bedrooms, Disabled toilets on ground floor, Wheelchair Access, Wheelchair Access To Reception, Wheelchair Access To Restaurant, Wheelchair Access To Bar
Useful Info Show/hide
- From 14:00 hours
- Until 11:00 hours
- 31/07/2012 to 31/08/2012 - SOMETHING NEW ON OSBORNE ROAD. A NEW RESTAURANT IS OPEN IN OUR HOTEL. 'A TASTE OF PERSIA' OPEN MONDAY TO FRIDAY FROM 5 PM, SATURDAY 1PM-10PM AND SUNDAY 1PM - 9PM FOR BOOKINGS CALL 0191 2818181 The LateRooms.com rates for Jesmond Hotel in NEWCASTLE UPON TYNE are the total price of the room and not the 'per person' rate. All prices are inclusive of all local taxes.
- Pets are not allowed
Our reviews are from genuine LateRooms.com customers. We verify that the customer has stayed before leaving a review.
71% would recommend it to a friend
This hotel was very clean with a comfortable bed and large en suite.
It is great value for money for an overnight stay. Would stay again, but not bother to pay extra for breakfast which was not worth the money.
An overnight stay in Newcastle
We stayed one night in Jesmond and chose this hotel for its location and for the price.
From this location we were just out of all the noisy bars and hotels along the Osbourne Road, and near enough to walk into Newcastle city centre. We could only get a twin room but we weren't disappointed.We paid under £40 for an overnight stay and had an en-suite room, tea and coffee making facilities, clean sheets and white fluffy towels. The room was at the back of the building, which made it particularly quiet. We had a slight problem with the shower as we had to use the shower head from the taps in the bath, which made it a bit awkward, but we had plenty of hot water and the power was good, so it was a small inconvenience. The beds weren't particularly comfortable but for one night only, it was acceptable. We liked the fact that the hotel did not take hen or stag parties, and did notice it was full of couples mainly. We were able to book in from 2pm and they gave us a parking permit for our car which was parked outside. We had to vacate by 11am the following day and give the parking permit back by that time, so we were unable to walk into the town centre that day and leave the car outside that day. The hotel had a restaurant attached to it, which we just popped in for a drink at the end of the evening, but did get chatting to some people who had eaten there and they said they had a lovely meal, the prices were extremely good value for money. It looked like breakfast was served here the next morning, but we decided not to have breakfast and headed off early that day. All in all, a good hotel for the money, a little dated, but clean and tidy, and in a good location.

domain: travel


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Projecten per jaar
The SNAPduo ßeta-Tetra ST (IDEXX Laboratories Inc. Westbrook, Maine, USA) is a competitive receptor test for the rapid and simultaneous screening of residues of ß-lactams (penicillins and cefalosporins) and tetracyclines in raw milk. The test is an improvement of the SNAPduo ß-lactam-Tetra test, because it is run with an incubation at ambient temperature (15-30ºC), so an incubator is no longer needed. The time to result for the assay is approximately 7 minutes (an estimate 45 seconds of milk flow time and 6 minute of incubation at ambient temperature to allow for color development). In addition, compared to current SNAPduo ß-lactam-Tetra test, the SNAPduo ßeta-Tetra ST expands the detection capability of ß-lactams in milk: more ß-lactam antibiotic residues can be detected by SNAPduo ßeta-Tetra ST at the MRL levels.
This new test was validated at ILVO-T&V (Technology & Food Science Unit of the Institute for Agricultural and Fisheries Research of the Flemish Community) according to Commission Decision 2002/657/EC and to the CRL guidelines for the validation of screening methods for residues of veterinary medicines (Anonymous, 2010). The following analytical parameters were checked: test specificity, detection capability, and test robustness (impact of deviation of the test protocol, impact of the milk composition, and batch differences of reagents). Further the suitability of the SNAPduo ßeta-Tetra ST to screen different milk types (UHT milk, sterilized milk, reconstituted milk powder, thawed milk) or milk from animal species other than the cow (goat, ewe, and mare) was also tested. Finally, the test was integrated in the monitoring of dairy samples to check the occurrence of false negative or false positive results, and the test was also included in two national ring trials and an international proficiency study.
The test was very specific; no interaction was noticed by compounds of antibiotic families or chemotherapeutics other than ß-lactams except for the interference by clavulanic acid. All ß-lactams with a Maximum Residue Limit (MRL) in milk were at least in 95% of the replicates detected at their respective MRL except for cefalexin (ccß >7,500 µg/kg) and the 4-epimer of chlortetracycline (ccß=175 µg/kg). The detection capability for doxycline, a compound without MRL in milk, was 25 µg/kg. The detection capability of the SNAPduo ST for ß-lactam antibiotics is comparable to the detection capability of the SNAP Beta-Lactam ST (Reybroeck & Ooghe, 2011).
The repeatability of the reader and the test were very good. The test result remained reliable even when performing the SNAPduo ßeta-Tetra ST with the timing changes of different steps in the testing protocol including delay in activation of SNAPduo device, delay after dissolving the pellet in the milk and delay of reading. Also, the impact of milk parameters (somatic cells, total bacterial count, fat and protein content, pH) was tested as part of the robustness testing. No interference by these milk parameters was noticed except for milk with a high number of somatic cells (> 106 ml-1) (both channels), milk with a high protein content (>4 %) (both channels) or milk of pH 6.0 (ß-lactam channel). No significant differences were noticed in testing different milk types (raw milk, UHT-milk, sterilized milk, reconstituted milk powder, or thawed milk) and other species animal milk (goats’, mares’, or ewes’ milk). Therefore, SNAPduo ßeta-Tetra ST offers the flexibility of testing all different milks. No significant differences in testing capability were found between two batches of reagents of SNAPduo ßeta-Tetra ST.
Out of the data of this validation study it can be concluded that the SNAPduo ßeta-Tetra ST is a very fast, simple, and reliable test for the control of residues of ß-lactam and tetracycline antibiotics in tanker milk at the entrance. The test could also be used at farm level in order to prevent tanker milk contamination. The test is also giving reliable rest results for different milk types and milk of animal species different from the cow (goat, ewe, mare).
|Validation of SNAPduo Beta-Tetra ST Test Kit
|Gepubliceerd - 18-okt.-2012
- 1 Actief
1/01/10 → …

domain: biology


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Shrimping in Maine at All-Time Low
Typically, the shrimping season in Maine runs from December through the spring. But this year, after historically low harvests, the season was cut short after just a few weeks. The shrimp supply has been so depleted by overfishing and warming waters that fishermen were returning with little to show for their efforts. Maine's shrimp harvest has declined sharply in recent years—in 2011 shrimpers caught about $11 million worth of shrimp, in 2012 they caught just $2 million. Regulators are hoping an off-season will allow time for the shrimp population to return to normal levels. Maine shrimp are often exported to Europe, though some New England restaurants and consumers will purchase them as well. The shrimp are smaller and sweeter than farmed shrimp.
Cranberry Surplus to Become Part of School Lunch
Because of an unexpectedly large cranberry harvest in Canada this year, which flooded the American market, American cranberry producers experienced a huge surplus. The USDA purchased some of the surplus for food assistance programs, but the 75 million pounds of extra cranberries needed more markets. So the Congressional Cranberry Caucus petitioned the USDA to add cranberries to their "Foods Available List," which details what foods schools can buy as part of their breakfast and lunch programs. The USDA approved dried cranberries and cranberry sauce—a partial solution, though one that will require processing and added sugar. Meanwhile, cranberry growers are looking to target international markets for the rest of the surplus.
Marion Nestle Writes Last Column at San Francisco Chronicle
Marion Nestle is one of the preeminent writers on American food policy and politics. This month, she published her 70th and final column in the San Francisco Chronicle, which recently closed its stand-alone food section. Nestle writes about her optimism for the future of a healthy, sustainable food system. She recaps a few of the strides made this year in food policy, including the success of Michelle Obama's Let's Move! program, the FDA's voluntary regulations on antibiotic use in meat production, and fast food workers' continued and growing demands for higher wages. She also calls for further investment in a "stronger and more compassionate safety net for the poor and unemployed." Nestle will continue to write on her personal blog as well as other publications.
Farm Bill Negotiations Could Wrap Up This Month
Senator Chuck Grassley (R-IA) reportedly remains confident that Congress will send a completed, compromised Farm Bill to the President by mid-January. The Bill has been stuck in negotiations for several months. Congress's two main points of contention were changes to direct subsidies for farmers, and cuts to the food stamp program. Initially, the House bill called for $40 billion in cuts to SNAP over 10 years, whereas the Senate bill called for $4 billion in cuts. Sources say the final compromise will be around $10 billion in cuts.
All products linked here have been independently selected by our editors. We may earn a commission on purchases, as described in our affiliate policy.

domain: politics


Paramo Bentu Fleece Jacket Moss
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Irish go 2-2 at HastingsThe Rosemount wrestling team has traveled to Hastings for a dual-meet tournament for the past several years. It’s typically the first competition of the season for the Irish. With top-notch teams at the meet, it can provide the wrestlers and coaches a glimpse into what is needed for improvement as the season wears on.
By: Brian Hall, Rosemount Town Pages
The Rosemount wrestling team has traveled to Hastings for a dual-meet tournament for the past several years.
It’s typically the first competition of the season for the Irish. With top-notch teams at the meet, it can provide the wrestlers and coaches a glimpse into what is needed for improvement as the season wears on.
The Irish have been 0-4 as a team at the tournament for the past three years. The results typically mean there is plenty of work to do. However, the meet often includes several ranked teams, and Rosemount does improve from that point.
If that continues to be the case, the Irish might like what happens this season.
Rosemount went 2-2 at last weekend’s meet.
“All the teams in the tournament, besides us, were ranked or honorable mention,” Irish coach Brett Larson said. “We beat Centennial and Prior Lake. We felt good coming out of it with victories against those two teams. And we were still forfeiting two weights. It’s a positive start. That was good for us. It’s about where we are at.
“We found out we have some veteran wrestlers who I think will be right there in matches. And we have some new guys, the varsity level is a big jump, and I think they will fit right in and compete.”
Last weekend’s Hastings meet again brought quality competition. Two teams ranked in the top 12 in the state and two other honorable-mention teams. Rosemount was not one of those teams.
But the Irish left the meet with a 2-2 team record regardless.
Rosemount beat honorable-mention worthy Centennial 35-31 in the opening round. Coon Rapids, No. 11 ranked, beat the Irish 52-15 in the second round.
In the third round, No. 2 Hastings beat Rosemount, 59-15.
The Irish then came back with a 31-29 victory against Prior Lake in the fourth round.
Garrett Bothun went 3-0 during the meet. Tony Marthaler went 2-1 and Tyler Sandoz finished 2-2. The three senior captains were leading the way by example in the first action of the season.
Some of the other returning experienced wrestlers also provided key points.
Paul Domeier, Josh Francois and Adam Jackson each went 2-2 during the meet, often meeting up against wrestlers who were ranked individually.
Ninth-grader Danny Rosa won his first varsity match as well.
“We knew it was going to be tough,” Larson said. “It’s kind of a meat-grinder to have four duals in one day, and especially going up against four quality teams. It’s a long, tough day. We came out ahead going 2-2. We’re pleased with the outcome and we’ll move forward from there.”


Mark Webber believes Red Bull will have to work on reducing understeer on its RB9 after the first day of pre-season Formula 1 testing at Jerez.
The Australian said that the new car felt similar to the 2012 RB8 that won both the drivers' and constructors' championships, but he added that the team had areas to work on before testing resumes on Wednesday morning.
"The car was very understeery today, so we need to improve that tonight and get it a little more responsive," Webber told reporters at Jerez.
"Obviously this was the first day at school. We're not having a grand prix tomorrow, thank God, so we'll work hard, as will everybody else.
"The car's not massively different. The last few years we've had regulation changes, but this year it feels pretty similar.
"We've got some front wing stuff going on, but I felt pretty comfortable pretty quickly."
Webber added that the combination of the new 2013-spec Pirelli tyres and the rough Jerez track surface could be exaggerating any car traits.
"The tyres are going away quite a bit," he said. "If you see a car on fresh tyres the performance is quite nice, if you see one on older tyres it doesn't look very nice.
"The naked eye can even see the problems. The tyres are struggling to do quite a few laps, and you see the times in the 1m22s and 1m23s.
"But this track is always hard on tyres. You can always scare yourself here and then get to other places and it's OK."
AUTOSPORT special testing coverage:


Let's be real for a moment. A netbook is an awesome device if all you want is something ultra-portable to knock around the Web, send emails, and even do a little bit of productivity work. But are you going to replace your daily notebook with a netbook? Probably not. Even with dual-core Atom chips now the norm, netbooks don't possess the power or capabilities of a full-fledged notebook.
A solid alternative is a true ultra-portable like the Toshiba Portege R835-P50X. The R835 has all the makings of a much more powerful notebook but in a highly portable 13.3-inch form factor that's one of the lightest around. It's like having the convenience of a netbook, only instead of an Atom processor and a threadbare feature-set, the R835 packs Intel's Sandy Bridge platform and an optical drive, two things you may never see in a netbook. We'll get to the pros and cons, but first, a quick peek of the spec sheet:
- 13.3-inch widescreen display (1366x768)
- Intel Core i3 2310M processor
- Intel HD 3000 graphics
- 4GB DDR3-1333 RAM
- 640GB hard drive (5400 RPM)
- DVD burner
- Intel Wi-Fi with WiDi technology
- GbE LAN
- 1 x USB 3.0, 1 x eSATA/USB (2.0) combo with Sleep and Charge, 1 x USB 2.0, HDMI
- Multi-card reader
- 6-cell battery
- Price: $889
What We Liked:
- Light As A Feather? Almost!: At just 3.2 pounds, the R835-P50X is one of the lightest 13.3-inch notebooks out there and is only slightly heavier than Apple's ultrathin MacBook Air and Samsung's Series 9. And that's with an optical drive. When other notebooks go on a diet, the R835 is the picture they post on their refrigerator as inspiration.
- Comfortable Keyboard: Unlike most ultrathins, the R835's keyboard is a delight to type on, provided you dig the chiclet-style keys that are all the rage these days. The click action is nearly perfect and doesn't vex us as some notebook keyboards are prone to do. That said, this is a 13.3-inch notebook, so don't expect a numpad. It also lacks a backlight, but even with these drawbacks, we give the R835's keyboard two thumbs up.
- Full Featured Notebook: Intel Sandy Bridge platform? Check. Optical drive? Check. 4GB of RAM, 640GB hard drive, and USB 3.0 with Sleep and Charge capability? Check, check, and checkmate. For as portable as the R835 is, Toshiba managed to cram a ton of hardware and features in and around its ultraportable. The R835 is only slightly bigger and heavier than a netbook, but on the hardware side, it has much more in common with traditional notebooks. You're not going to score just shy of 5,100 in PCMark Vantage with a netbook, but that's what we recorded with the R835. It also represented itself well in PCMark 7 (1,872), and our assortment of synthetic memory and disk benchmarks.
- High-Tech Connectivity: Toshiba scores a solid 'A' for all the connectivity options available with the R835, starting with the USB 3.0 port. Not only will it accommodate SuperSpeed devices, but it will also charge your gadgets even when the system is powered off. There's also an eSATA port, HDMI port, and perhaps best of all, the R835 is ready to communicate with an Intel WiDi (Wireless Display) adapter to project multimedia content to your HDTV. That's rad in and of itself, let alone for a device this small.
- Battery Life: The R835 has nothing to be ashamed of in terms of battery life. We used Battery Eater Pro to drain the 6-cell battery, a particularly brutal benchmark that measures a worst case scenario. And if that weren't enough, we configured the screen to never turn off and remain at its brightest setting for the duration of the test. Even with the odds clearly stacked against the R835, it managed to bench 120 minutes of runtime. In real-world usage, you can expect much longer.
What We Didn't Like
- Poor Quality Screen: The Achilles heel is the 13.3-inch screen, and in more ways than one. First, it's only 13.3 inches, and even though it supports a 720p resolution, it's not the same experience as using a 15.6-inch notebook. We noticed vertical lines running throughout the screen, and it has a strict viewing angle that quickly degrades if you don't view the screen dead-on.
- No Love for Gamers: You don't buy a 13.3-inch laptop for gaming, and the R835 is no exception. It doesn't boast discrete graphics, the integrated Intel HD 3000 chipset steals memory from the main system, and it doesn't support DirectX 11 visuals.
- Overly Sensitive HDD Protection: The R835 does a great job of detecting vibrations and parking the hard drive heads to keep your data safe should you bump or drop your notebook, but it's overly sensitive. The slightest movement tends to set it off. We suppose it's better to be safe than sorry, we just don't think the R835 needs to be quite this skittish.
Our comparison of the R835-P50X with a netbook is simply to show you that you can have a bona fide computing experience in an ultraportable design that doesn't limp with underpowered and/or missing hardware. And make no mistake, though it only weighs 3.2 pounds and measures 13.3 inches, the R835 is a solidly spec'd notebook that attempts to combine the portability of a netbook with the power of a laptop, and mostly succeeds.
It's not a gaming notebook, nor is it as sexy as a MacBook Air. We're also not overly impressed with the display's strict viewing angle. But the R835-P50X makes up for its few shortcomings by not only living up to what you expect an ultraportable to be, but by going above and beyond. The dual-core Sandy Bridge processor (Core i3 2310M) provides a solid foundation, both in terms of power and power management. Combined with 4GB of DDR3 memory, a spacious 640GB hard drive, DVD burner, and a large 6-cell battery, the R835 provides plenty for road warriors to smile about.
Our Score: 4.5 out of 5


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The partnership between Red Bull Racing and Aston Martin will continue into 2017, Red Bull confirmed on Tuesday.
Branding on the Red Bull Formula 1 chassis will continue, while bigger news has come in terms of the AM-RB 001 hypercar.
Red Bull and Aston Martin announced that all 150 road-going cars of the 175 cars built (the other 25 are track-only specials) have been sold and customer deliveries will begin in early 2019.
An AM-RB 001 prototype is expected to run for the first time by the end of this season.
“We first conceived our Innovation Partnership with Aston Martin in the realization that it could be truly pioneering,” said Christian Horner, Red Bull Racing team principal.
“In blending our distinct but unique skills under a shared creative vision, we have already seen tangible development to both of our brands and businesses. The extraordinary success of the AM RB-001 is testament to the expert and collaborative spirit in which it was forged, and extending our relationship with Aston Martin through 2017 was a simple and pleasing decision.”
Aston Martin President and CEO Andy Palmer added, “By bringing together the talents of Red Bull Racing and Aston Martin, AM-RB 001 is destined to become the defining hypercar of this decade and a hugely desirable investment for collectors and enthusiasts.
“Our relationship with Red Bull Racing has done for Aston Martin exactly what we expected it to do,” he continued. “It is helping us to continue to build our brand across the globe. Partnerships like this are good for business both in terms of technical innovation and brand awareness, so we are pleased to continue into 2017.”
Webb and Tomac won the last four championships with two apiece in alternating years, but they were not one another’s primary rival for most of those seasons. On the average, however, the past four years show an incredible similarity with average points earned of 21.0 for Webb and 21.3 for Tomac. With five wins so far this season, Tomac (23 wins) leads Webb (19) in victories but Webb (43) edges Tomac (41) in podium finishes during this span.
Sexton still has a lot to say and after winning last week in Detroit, he is speaking up. The Supercross numbers are against him entering Seattle, however, because a points’ deficit this large after Round 10 has been erased only once. In 1983 David Bailey was 47 points behind Bob Hannah, and like Sexton he was also in third place. Bailey took the points’ lead with one race remaining.
The seven points Sexton was penalized last week for jumping in a red cross flag section in Detroit could prove extremely costly.
In fact, it has been a series of mistakes that has cost Sexton the most. In the last two weeks, he lost 10 points with a 10th-place finish to go with his penalty. Erase those, and all three riders hold their fate in their hands.
Plessinger’s heartbreak in Detroit is still fresh, but the upside of his run is that was his best of the season and could turn his fortunes around. Prior to that race, he led only seven laps in three mains. He was up front for 20 laps in Detroit with five of those being the fastest on the track.
Last week’s win by Hunter Lawrence tied him with his brother Jett Lawrence for 17th on the all-time wins’ list. With the focus shifting to 250 West for the next two rounds, Jett has a great opportunity to pull back ahead. The real test will be at the first East / West Showdown in East Rutherford, New Jersey on April 22.
Last Five Seattle Winners
450s 2022: Eli Tomac
2019: Marvin Musquin
2018: Eli Tomac
2017: Marvin Musquin
2014: Ryan Villopoto