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By Gordon L. Rottman,Alan Gilliland,Johnny Shumate
Read Online or Download Browning .50-caliber Machine Guns (Weapon) PDF
Best military history_1 books
The yank Civil conflict used to be a turning element within the historical past of war, as Napoleonic strategies met lethal new know-how. Cannons and rifles had develop into extra exact at longer levels, rapid-fire pistols gave cavalry a brand new weapon, and the telegraph and railroad thoroughly altered either strategic and tactical pondering.
Even supposing so much bills of the Civil War's New Mexico crusade have fascinated about the accomplice attempt, far away Bugles, far away Drums brings to lifestyles the epic march of 1,000 males recruited from Colorado's cities, farms, and mining camps to struggle 3,000 accomplice infantrymen in New Mexico. Drawing on formerly neglected diaries, letters, and modern newspaper money owed, army historian Flint Whitlock brings the Civil warfare within the West to lifestyles.
The Virginia military, led by way of Commodore James Barron, raised greater than fifty vessels to assist the struggle opposed to the British Empire. The ships saved open very important exchange passages to the West Indies that allowed for items and provides to arrive American seashores regardless of English blockades. Barron defended his birthplace on the conflict of Hampton, suffered near-destruction by the hands of Benedict Arnold and supported the French army within the decisive victory at Yorktown.
Seán Hartnett grew up in Cork within the Seventies the place he saw the worstof the northern problems with fascination. regardless of his family’s strongrepublican ties and his personal try and subscribe to the IRA, Hartnett shockedfamily and neighbors while he replaced allegiance and joined the BritishArmed Forces. In 2001 Hartnett returns to his local eire, yet this time as a memberof the British Army’s so much secretive covert counter-terrorist unit in NorthernIreland, Joint Communications Unit Northern eire aka JCU-NI, the FRU,14 Intelligence corporation, or just ‘The Det’.
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Extra info for Browning .50-caliber Machine Guns (Weapon)
Browning .50-caliber Machine Guns (Weapon) by Gordon L. Rottman,Alan Gilliland,Johnny Shumate

domain: history


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The first broadcasting of a radio transmission consisted of Morse code (or
wireless telegraphy) ... In the early days, radio stations broadcast on the long
wave, medium wave and short wave bands, an...
Since its inception, radio's impact on American culture has been immense.
Modern popular culture is unthinkable without the early influence of radio.
May 31, 2007 ... Radio has transformed society three times, not to mention giving birth ... The early
inventors studied the work of Scottish physicist James Clerk ...
Emergence of Radio in the 1920s and its Cultural Significance. Most radio ...
Early radio's, including crystal radios, needed antennas to operate well. The most
The introduction of radio to the average household allowed many in the world to
... How does the radio impact our society? ... How did the steamboat impact
society? ... Influence of Early Radio · History of the Radio · Cultural Impact of
The Beginnings of Radio and Sports Programming. Three sports and four
electronic manufacturers/communications companies dominated early mass ...
the early history of radio. ... Even then the government responded to the political
influence of big business. This influence included corporations like AT&T and ...
At the start of the decade 12 million American households owned a radio, and ...
News broadcasts also influenced the way the public experienced current affairs.
How would radio influence the nation's youth, growing up with radio as a given?
... and comedy shows often characterized as "early radio"—those arrived in the ...
transmitting as early as 1916, the first scheduled and advertised radio program in
..... lin's influence had waned, however, due in part to negative reactions.


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Pakka Tamil Movie Live Review & Ratings
Total Reviews: 5
26% out of 100% from below 5 reviews
Pakka movie review and rating arround the web. Pakka movie average rating is 1.30 out of 5.0 based on 5 reviews. Average movie review percentage is 26% out of 100% from below websites (IndiaGlitz, Times of India - India Times, indiatoday.intoday, FirstPost, The Indian Express, ).


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No Going Back On Petrol, Electricity Subsidies – FG Insists
The Federal Government has said that it does not have any plan of rescinding its policy on subsidy removal on Premium Motor Spirit (PMS), popularly known as petrol. The Minister of Finance, Budget and National Planning, Zainab Ahmed disclosed this on Tuesday during a virtual meeting in Abuja.
She also stated that the government did not make any provision for electricity subsidy in 2021 and would not subsidise power. Responding to a question on whether the reduction in petrol price about a month ago had led to the return of subsidy, Ahmed said, “The answer is a flat no.
“We are not bringing back fuel subsidy. We didn’t make provision for fuel subsidy in the budget. The impact of what was done was reducing some of the cost components that were within the template. “And also related to it, on matters of electricity subsidies, no provisions have been made for subsidy for fuel and no provisions have been made for subsidy for electricity.”
Click on the link below for full report

domain: news


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Michael Gove’s quote continued: “Making access to the NHS fairer is part of making migration fairer overall… it’s not right that people from Bulgaria and Slovenia can come here without any controls and have automatic rights that people from Bangladesh and Singapore do not.”
His cabinet colleague Matt Hancock added to the point when, on Twitter, he said: “Everyone should make a fair contribution towards our NHS - so after Brexit we’ll extend the NHS surcharge to all non-UK residents.”
EU citizens do not pay less towards the NHS than other visitors or immigrants to Britain. They pay more. They also pay more than the average Briton.
The Migration Advisory Committee, the government’s independent consultant, estimated in September 2018 that, over their lifetime, migrants from the European Economic Area would pay an average of £78,000 more to the UK exchequer — and thus to the NHS — than people born in Britain. It also found that “EEA migrants contribute much more to the health service and the provision of social care in financial resources and through work than they consume in services.”
Oxford Economics said that “the average UK-based migrant from Europe contributed approximately £2,300 more to UK public finances in 2016/17 than the average UK adult. In comparison, each UK-born adult contributed £70 less than the average, and each non-European migrant contributed over £800 less than the average… Their (EU citizens’) net contribution was £4.7 billion in 2016/2017.”
Hancock’s assertion that “after Brexit, we’ll extend the NHS surcharge to all non-UK residents” is muddled and wrong. The surcharge only applies to UK residents, not to foreign visitors, and the Tories have not announced a plan to extend it to visitors.
Visitors to Britain who hold a European Health Insurance Card get free health treatment, as long as their need for it was unexpected, or “unplanned” — just as all Britons do in other EU countries. The NHS can claim the cost of treatment back from the visitor’s government. Non-EU citizens residing in Britain already pay the surcharge.
The Tories’ proposed change would therefore only apply to EU citizens who come to reside/live in the UK.
Hancock and Gove seem not to understand the difference between UK residents and visitors, or else they deliberately muddle the two to mislead the public.
Gove was quite wrong to claim that “people coming from European countries... can access free NHS care without paying in while others make significant contributions.”
As shown above, EU migrants to the UK contribute more to the budget of the NHS than the average UK citizen, and far more than they take out.
Misleading the public on the emotive topic of immigration is scurrilous. Stoking a common misconception that British citizens pay for the health care of EU migrants is the kind of deception that far-right parties stoop to.


ePhotozine published the interview with Olympus Imaging Global Marketing Manager Toshiyuki Terada. Here are a couple of notes:
Dynamic range: “On Dynamic range, we have compared the dynamic range to the competition, and the E-M1 Mark II at ISO200 gives 4.2 steps, which is better than the E-M1, (3.8steps), and APS-C cameras such as the Canon EOS 7D Mark II (3.5 steps), and Fujifilm X-T1 (3.5steps).”
New 20MP sensor: “The 20mp Live MOS sensor, different to the PEN-F, with Phase Detection focus on chip. There’s a new processing engine, the TruePic VIII – giving higher image quality, there is a 1 stop noise performance improvement over the E-M1.”
About Full Frame users: “We find a lot of people buy into the OM-D system and start trying it, and end up leaving the Full-Frame system at home.”
E-M1II price: “Slightly more than the E-M1, depending on location, and global economics, for example, Brexit.“
Damn you british people are going to cost us a lot :)
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‘In July the sun is hot / Is it shining / No, it’s not!’ As musical comedy duo Flanders and Swann pointed out back in the sixties, the weather in July can be chancy, but nevertheless, it’s a great month for gardeners. The days are long, and you can start to really enjoy the fruits of your labours in the veg patch. To make this year your best harvest ever, here are a few tips on what to do now, as well as how to get the better of plant pests and diseases.
Key jobs for the veg garden in July
- Feed container-grown vegetables such as tomatoes and peppers fortnightly. Use a general purpose liquid feed until the first flowers appear, then switch to a high-potash feed like Tomorite which promotes fruit development.
- Tie cordon tomatoes back to stakes, and pinch out any side shoots that appear where the leafstalks join the main stem. This allows the plants to focus all their energy on producing fruits.
- Start harvesting early potatoes in early July, about 10 weeks from planting. They taste best when eaten fresh, so dig them up as you need them.
- Keep on earthing up maincrop potatoes until there’s a ridge of soil around 30cm high around each plant stem.
- Water container-grown plants daily in hot weather.
- Harvest beans and courgettes regularly to encourage the plants to produce more.
What’s wrong with my plants?
Tomato blight is a common problem in wet weather. Brown rotting patches on fruits and shrivelled leaves are the first signs of blight, and unfortunately, there’s nothing you can do except get rid of affected plants immediately. Tomato blight thrives in warm damp conditions, so good ventilation and careful watering are key to reducing the risk of an attack. Avoid wetting the leaves of your plants when watering.
Powdery mildew can affect squash, courgettes and pumpkins, especially in hot weather. A fungal disease, it appears as a white powdery coating on leaves. Mulch plants and water them regularly to avoid drought stress, and make sure there is enough space between plants for air to circulate. Remove affected leaves as soon as possible.
If your broad beans are plagued by aphids, pinch out the growing tips of the plants once the first pods appear, as this new soft growth is what attracts the aphids. As a bonus, this will also give you bushy plants which produce more beans.
Sow lettuce, rocket and radish seeds every fortnight, and you’ll be set for salad all through summer. To stop lettuce bolting (producing flowers), sow it where it will be partially shaded by surrounding plants.
If you sowed winter cabbage and leeks in spring, transplant the seedlings to their final positions now.
And if you’ve not planted anything yet, there’s still time. Hurry down to our garden centre, where you’ll find everything you need to start growing your own delicious fruit and vegetables.

domain: agronomy


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Pancakes the Pig has made her pick.
With no hesitation, the Fort Worth Zoo’s potbellied pig nosed out a winner this week for the Super Bowl game Sunday: the Seattle Seahawks.
Before you grunt at the idea of letting zoo animals pick football games, check out their won-lost record.
In the last four years, the zoo’s stable of football analysts has picked four Super Bowl winners.
Last year’s winning pick for the Baltimore Ravens came only after a Super Bowl-worthy controversy.
Tamba the Warthog strolled to center stage and favored the San Francisco 49ers.
But just like in real life, the zebras came into play.
Zoo zebras Missy and Henry burst into the announcement and took their own look at the decision.
After further review, they declared the Ravens the official zoo favorite.
This year, Pancakes the Pot-Bellied Pig took her first turn as prognosticator.
Weighing in at 94 pounds, 3-year-old Pancakes is a star of the zoo’s outreach programs. A handler walks her on a leash.
Presented with footballs for both the Seahawks and Denver Broncos, Pancakes pranced directly to the Seahawks ball.
Just to double-check, the zoo staff switched the balls and tried again.
Pancakes proved she’s a Seahawks rooter.
For the record, gamblers in Nevada alone will bet more than $100 million on Sunday’s game. Bookmakers have made Denver the favorite.
It’s tough to pick against the Broncos. They have played more games in Fort Worth than any other pro football team, thanks to three 1960s appearances as a visiting team for Dallas Texans and Kansas City Chiefs preseason games at Farrington Field.
But based on the zoo’s record, put your money on the pig.


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Release Day Review ~~ A Thousand Letters by Staci Heart
Today we have the release day for A Thousand Letters by Staci Hart! I love this fantastic new contemporary romance inspired by Jane Austen’s Persuasion. Check it out and grab your copy today!
Title: A Thousand Letters
Author: Staci Hart
Genre: Contemporary Romance
About A Thousand Letters:
Sometimes your life is split by a single decision.
I’ve spent every day of the last seven years regretting mine: he left, and I didn’t follow. A thousand letters went unanswered, my words like petals in the wind, spinning away into nothing, taking me with them.
But now he’s back.
I barely recognize the man he’s become, but I can still see a glimmer of the boy who asked me to be his forever, the boy I walked away from when I was young and afraid.
Maybe if he’d come home under better circumstances, he could speak to me without anger in his voice. Maybe if I’d said yes all those years ago, he’d look at me without the weight of rejection in his eyes. Maybe if things were different, we would have had a chance.
One regretted decision sent him away. One painful journey bought him back to me. I only wish I could keep him.
*A contemporary romance inspired by Jane Austen’s Persuasion*
Louisa’s 4.5 Blush Review
Ok – I am always honest when I review books. Ok, here it is…I have never read Jane Austen and therefore I have never read Jane Austen’s Persuasion, but after reading A Thousand Letters by Staci Hart – I guess I need to.
A Thousand Letters is a book that I am surprised I liked so much, why you ask? Well – my eyes were blurry for most of the time I was reading, blocked with unshed and yes, maybe, ok – a lot – of shed tears. The characters in this book were so beautifully written that they were my friends, I was there sitting with Rick and his family. Remembering the beauty of life at the ends of his. I wanted him to give me the talk to last me a lifetime that he shared with Wade and Elliot.
Wade and Elliot – a couple with so many obstacles between them. Wade was such a strong man on the outside but was slowly dying on the inside. His intentions were good, he loved Elliot but didn’t want to hurt her. Some may stubborn, but I would say blinded by an unbelievable love.
Elliot – this sweet, sweet woman. Many would say – a doormat, but to me she is a selfless, giving and caring woman.
I don’t know how else to say this but this book had all the feels I need when reading. My first Staci Hart book but not my last.
I do need to acknowledge a “shout out” to Brittainy Cherry. I am a huge fan of her work and with her recommendation, I read this book – so thank you, thank you, thank you to Brittainy for sharing this with me.
Staci Hart Bio:
Staci has been a lot of things up to this point in her life: a graphic designer, an entrepreneur, a seamstress, a clothing and handbag designer, a waitress. Can’t forget that. She’s also been a mom, with three little girls who are sure to grow up to break a number of hearts. She’s been a wife, even though she’s certainly not the cleanest, or the best cook. She’s also super, duper fun at a party, especially if she’s been drinking whiskey. Her favorite word starts with f and ends with k.
From roots in Houston, to a seven year stint in Southern California, Staci and her family ended up settling somewhere in between and equally north, in Denver. They are new enough that snow is still magical. When she’s not writing, she’s sleeping, cleaning, or designing graphics.

domain: artistic


At the other end of the FCS
size spectrum is the Manned Ground Vehicle Chassis Testbed, which demonstrated its agility and speed during circuits of a small test track at APG's Perryman Test Range.
The initial system configuration of the FCS
contained nine manned ground vehicles, four classes of unmanned aerial vehicles, four different unmanned robotic ground vehicles, and numerous unmanned ground sensors, communications networks, and intelligence systems.
selection gives us the opportunity to serve the Army's transformation needs and advance the ground robotics field in support of our troops on the ground.
is composed of The Soldier, supported by an advanced communications and digital information network that connects 18 manned and unmanned ground and aerial vehicles and sensors and munitions.
By teaming with SAIC, we were able to merge the best of each of our concepts to provide the lowest risk approach to achieving initial operational capability in this decade and a rapid evolution to the most capable FCS
force possible," Ron Prosser, vice president of Advanced Space and Communications for Phantom Works said.
We are not only supplying the most technically advanced parts planning and service system available, but also providing our experienced planning team to assist FCS
to consistently exceed record service levels with minimal inventory.
It will provide the network capability that is the backbone of FCS
for both current-force platforms and also for future-force manned and unmanned ground vehicle and unmanned air vehicles.
The agreement between CCC and FCS
is logical for us as a company," said FCS
' CEO, Jacqueline Soechtig.
BAE Systems, as part of the firewalled FCS
One Team, teamed with General Dynamics, is already working to develop and field a family of highly deployable Manned Ground Vehicles that will be key supporting systems linked through the overarching network that will enable the FCS
-equipped Units of Action to effectively complete their missions.
SCOPE will enable FCS
to leverage the advantages of mobile handheld terminals to track and manage cargo in real-time within the cargo terminal.
According to Dennis Muilenburg, Vice President and FCS
Program Manager for Boeing, "Robots and robotic technology are integral components of many FCS
LynuxWorks enables developers to easily move FCS
applications between those that have been developed for standard Linux environments and those targeted for embedded RTOS platforms with no costly or lengthy porting process.
iRobot is charged with developing a next-generation Small Unmanned Ground Vehicle (SUGV) for the groundbreaking FCS
The entirety of FCS
software depends upon the flawless operation of the SOSCOE," said Dennis Muilenburg, Boeing Integrated Defense Systems vice president and general manager of Future Combat Systems.
NEW YORK -- On July 30, 2004, Farm Credit Services of America, ACA (FCS
of America), a System Association headquartered in Omaha, Nebraska, and Rabobank, a Dutch banking cooperative, announced an agreement for Rabobank to acquire all of the shares of FCS
of America from its shareholders.


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By now all of us have got used to cooking almost everything at home. Months long lockdown in 2020 and partial lockdown in 2021 has upgraded many of us from cooks to home cooks. While imprisoned at home, we have done a lot of experiments in our kitchen. Back then, today we prefer to cook almost every meal at home as much as possible. And that is why we are constantly on the lookout for recipes that can help us replicate our favorite dishes from our favorite restaurants at home.
During our search, we found a Chicken Caesar Salad recipe that immediately reminded us of our favorite salad joint in town. For the unversed, Caesar salad is a simple dish made with lettuce, croutons, and dressing. You can add protein as per your choice in this salad.
Read also: These 5 bowls of nutritious food can be made in less than 20 minutes
How To Make Chicken Caesar Salad | Chicken Caesar Salad Recipe:
In this exclusive recipe, we’re making everything from bread croutons to salad dressings at home. it looks interesting? So, without further ado, let’s jump to the recipe.
How to prepare Chicken Breast:
- Take a chicken breast and add olive oil, black pepper powder, salt, garlic powder and keep it for an hour.
- Fry the marinated chicken on a tava (griddle) till it is cooked well from both the sides.
- Then cut the chicken into small pieces. Keep aside.
How to make Bread Croutons:
- Meanwhile, take 2 bread slices, cut off the edges and then cut them into small cubes.
- Now apply oil on the bread and bake it at 18 degree Celsius for 10-15 minutes. Keep aside.
How to make Salad Dressing:
- Take a bowl of cream and add grated paneer, black pepper powder, salt, chopped garlic and mix.
Now assemble the Chicken Caesar Salad:
- Take the chopped lettuce leaves in a bowl.
- Add chopped chicken and bread croutons to it.
- Add cream dressing and mix well. And voila!
A full bowl of Chicken Caesar Salad is ready for a filling meal.
Watch the full video of the recipe in the header section.
About Somdutt SahuInvestigator- Somdutt likes to call this himself. In the matter of food, people or places, she only wants to know the unknown. A simple aglio oleo pasta or lentils and rice and a good movie can make his day.

domain: food


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Giddens Gallery of Fine Art
Grapevine's Premier Art Gallery
“I enjoy painting sunflowers, and especially in the summertime. Their bright yellow faces have a way of turning a hot summer day into something special.”
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"The Life And Times Of Prophecy"
Feel The Vibe
Lindsay Lohan was the Guest Of Honor at tonight's Art Exhibit held by acclaimed artist and photographer Tyler Shields in Downtown Los Angeles tonight. Lindz def ...Click Here For More
Joanna and Marta Krupa, along with their "Kru" and Jessica Canseco gave their own little version of a Runway Show outside of Jerry's Deli as ...Click Here For More
On New Year's Day, I had just written a New Year's Post... And In It, I gave emphasis to the hope of turning our World ...Click Here For More


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Keywords: nano particlesClose
Proc. ASME. IMECE2001, Micro-Electro-Mechanical Systems (MEMS), 827-830, November 11–16, 2001
Paper No: IMECE2001/MEMS-23918
...: Nano particles, surface cleaning, acoustic streaming, megasonics, microcontamination INTRODUCTION Sac=(2v/o>r (1) With the International Technology Roadmap for The hydrodynamic (turbulent) boundary layer thickness is Semiconductors decreasing the particle removal requirements from 125nm (0.3-0.75/cm...
Proc. ASME. IMECE2020, Volume 11: Heat Transfer and Thermal Engineering, V011T11A047, November 16–19, 2020
Paper No: IMECE2020-24382
... that the mass transfer rate is enhanced significantly, it is because the interfacial area is enhanced by the addition of nanoparticles to the base fluids. Keywords: nano particles, sparged vessel, absorption refrigeration, sparged vessel, aqua ammonia system Nomenclature: dp Bubble diameter µL Dynamic...


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|Day's Range||0.1000 - 0.1000|
Long Term Follow Up Data from Phase 1 ALPHA/ALPHA2 Trials Demonstrate Potential of Allogeneic CD19 CAR T to Generate Durable Complete Responses Similar to Approved Autologous Therapies Presentation Focused on Patients (n=12) Treated with Phase 2 Regimen67% Overall Response Rate (ORR) and 58% Complete Response (CR) RateFive Patients (42%) Maintained a CR at Month 6; Four of Five CRs (80%) Ongoing Beyond Six Months, Including Two at 30+ Months and One at 24+ Months Clinical Safety and Immune Recov
Allogene Therapeutics (ALLO) reported earnings 30 days ago. What's next for the stock? We take a look at earnings estimates for some clues.
Sanofi's (SNY) phase II study on its novel investigational anti-CD40L antibody, frexalimab, meets the primary endpoint.
J&J (JNJ) submits a new drug application for a single tablet combination therapy of macitentan and tadalafil for the long-term treatment of pulmonary arterial hypertension.
AstraZeneca (AZN) reports statistically significant results from a late-stage study evaluating the combination of Imfinzi and Lynparza in patients with advanced endometrial cancer.
Apellis' (APLS) phase II MERIDIAN study on pegcetacoplan for the treatment of amyotrophic lateral sclerosis fails to meet primary and key secondary endpoints.
The mean of analysts' price targets for Allogene Therapeutics (ALLO) points to a 210.2% upside in the stock. While this highly sought-after metric has not proven reasonably effective, strong agreement among analysts in raising earnings estimates does indicate an upside in the stock.
PDS Biotech's (PDSB) shares gain as it announces encouraging interim data from the VERSATILE-002 study for treating HPV16-positive cancer patients.
Immutep (IMMP) shares surge on encouraging initial data from a triple combination therapy study, INSIGHT-003, for non-small cell lung cancer.
Icosavax (ICVX) surges on positive data from the clinical study of IVX-A12, targeting respiratory syncytial virus and human metapneumovirus in older adults.
SOUTH SAN FRANCISCO, Calif., May 24, 2023 (GLOBE NEWSWIRE) -- Allogene Therapeutics, Inc. (Nasdaq: ALLO), a clinical-stage biotechnology company pioneering the development of allogeneic CAR T (AlloCAR T™) products for cancer, today announced that it will participate in three upcoming investor conferences. TD Cowen 4th Annual Oncology Innovation SummitTuesday, May 30, 20236:30AM PT/9:30AM ET Jefferies Healthcare ConferenceFriday, June 9, 20239:45AM PT/12:45PM ET Goldman Sachs 44th Annual Global H
INOVIA (INO) shares surge 12% in the after-market hours, when its drug for treating a rare respiratory tract disease, INO-3107, receives orphan drug designation from the European Commission.
We can readily understand why investors are attracted to unprofitable companies. For example, biotech and mining...
PDS Biotech (PDSB) shares gain as it completes patient enrollment in the second arm of the VERSATILE-002 study for treating HPV16-positive cancer patients.
AbbVie (ABBV) announces the seventh FDA approval of its JAK inhibitor, Rinvoq, for the treatment of adults with moderately to severely active Crohn's disease.
Ranking among the most speculative practices in the equities arena, deliberately bidding up short-interest stocks may generate wildly robust gains. At the same time, higher risks for the intrepid market participant also signifies substantial risks. Fundamentally, triggering emotions of panic undergird short-squeeze stocks. When bearish traders “attack” a security, they aim to profit from their value erosion. However, if the underlying security rises in value, they lose. Because no upside ceiling
MindMed's (MNMD) mid-stage study, evaluating MM-120 for treating general anxiety disorder, reaches over 50% enrollment mark. Its top-line data is expected in late 2023.
Ultragenyx (RARE) stock climbs 5% after the FDA agrees to a protocol amendment to the phase I/II study of GTX-102 in pediatric patients with Angelman syndrome.
Intercept's (ICPT) fixed-dose combination of obeticholic acid and bezafibrate for the potential treatment of primary biliary cholangitis gets the FDA's Orphan Drug Designation.
PHIO surges on the FDA clearance of investigational new drug application for its lead product, PH-762, for the treatment of skin carcinomas.
Bayer's (BAYRY) oral FXIa inhibitor, asundexian, gets the FDA's Fast Track Designation, as a preventive treatment for stroke and systemic embolism in people with atrial fibrillation.
Arcus (RCUS) surges as it expands its previous research collaboration with partner Gilead, to focus on developing therapies for inflammatory diseases.
ImmunoGen (IMGN) shares surge exponentially in the past month owing to the positive data on the expansion study of Elahere for ovarian cancer. An encouraging initial sales uptake of its first marketed product, Elahere, also contribute to the surge.
FDA rejects ImmunityBio's (IBRX) filing seeking approval of Anktiva (N-803) as a combo-therapy in bladder cancer indication, citing deficiencies in an inspection of contract manufacturing firms.
Shares of Corvus Pharma (CRVS) surge 69% this week after the company provided updates on its pipeline development in the first quarter of 2023 earnings release.

domain: medical


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So likewise ye, except ye utter by the tongue words easy to be understood, how shall it be known what is spoken? for ye shall speak into the air. There are, it may be, so many kinds of voices in the world, and none of them is without signification. Therefore if I know not the meaning of the voice, I shall be unto him that speaketh a barbarian, and he that speaketh shall be a barbarian unto me. 1 Corinthians 14:9-11.
Ministers who labor in word and doctrine should be thorough workmen, and should present the truth in its purity, yet with simplicity. They should feed the flock with clean provender, thoroughly winnowed. There are wandering stars professing to be ministers sent of God who are preaching the Sabbath from place to place, but who have truth mixed up with error and are throwing out their mass of discordant views to the people. Satan has pushed them in to disgust intelligent and sensible unbelievers.
Some of these have much to say upon the gifts and are often especially exercised. They give themselves up to wild, excitable feelings and make unintelligible sounds which they call the gift of tongues, and a certain class seem to be charmed with these strange manifestations. A strange spirit rules with this class, which would bear down and run over anyone who would reprove them. God’s Spirit is not in the work and does not attend such workmen. They have another spirit. Still, such preachers have success among a certain class. But this will greatly increase the labor of those servants whom God shall send, who are qualified to present before the people the Sabbath and the gifts in their proper light, and whose influence and example are worthy of imitation.
The truth should be presented in a manner which will make it attractive to the intelligent mind. We are not understood as a people, but are looked upon as poor, weak-minded, low, and degraded. Then how important for all who teach, and all who believe the truth, to be so affected by its sanctifying influence that their consistent, elevated lives shall show unbelievers that they have been deceived in this people. How important that the cause of truth be stripped of everything like a false and fanatical excitement, that the truth may stand upon its own merits, revealing its native purity and exalted character.—Testimonies for the Church 1:414, 415.
This newly updated inspirational packet, compiled by Jerry and Janet Page, contains many resources on prayer including topics like: Praising God, abiding in Jesus’ love, guidelines for those desiring anointing, encouraging promises and quotes on healing, principles of intercessory prayer, how to pray with your spouse, powerful promises for parents, what to pray for non-Christians, when Satan called a worldwide meeting, and much more. (Download the entire packet or choose topics individually.)
Jesus showed His disciples through His daily life how to maintain a connection with His Heavenly Father. What He taught them is also vitally important for us today. We pray that you are blessed by this short devotional sharing time with Elder Wilson.
Total Member Involvement
Listen to this amazing and inspiring story, shared by Cami Oetman, and others in Adventist World Radio, of how God inspired the start of a massive cell phone evangelism effort. This initiative really is a great way to get involved. It's practical, relevant, and anyone, anywhere can participate. Watch this story and pray about how God might want you to take part.

domain: literature


text:
(June 2, 2021 / JNS) A survey commissioned by the American Jewish Committee, released on Wednesday, indicated that support for U.S. President Joe Biden among American Jews remains strong, while a political rift continues between the Orthodox Jews and other denominations, including unaffiliated Jews.
The annual survey by the AJC asked 1,000 Jews who self-identified with various denominations their opinion on Biden’s performance on various issues. According to an AJC news release about the survey, opinions between the various denominations still closely match Biden’s support in the 2020 election.
Jews in the United States came out overwhelmingly in favor of Biden in November; he received 68 percent of the Jewish vote with former President Donald Trump receiving 21 percent. An additional 4 percent of Jews voted for another candidate and 5 percent did not vote.
Still, Biden received just 12 percent from Orthodox voters, 61 percent among Conservative voters, 80 percent among Reform Jews, 99 percent from Reconstructionist, 86 percent from secular Jews and 71 percent from Jews without a specified denomination.
The numbers remain largely the same four months into Biden’s presidency.
- Job Performance: Biden’s approval rating among all Jews is 70 percent, with 26 percent disapproval. Nineteen percent of Orthodox individuals polled approve of Biden’s performance compared to 65 percent of those who said they were Conservative Jews, 80 percent who were Reform, 99 percent among Reconstructionist, 85 percent among secular Jews and 72 percent among Jews who did not affiliate with any denomination.
- U.S.-Israel Relations: Biden’s handling of U.S.-Israel relations was approved by 58 percent of Jews and disapproved by 27 percent; 19 percent strongly approved, 39 percent somewhat approved, 11 percent somewhat disapproved, 16 percent strongly disapproved and 15 percent had no opinion. Some 21 percent of the Orthodox approved of his handling of U.S.-Israel relations, while 47 percent of Conservative, 68 percent of Reform, 95 percent of Reconstructionist, 68 percent of secular and 59 percent of unaffiliated Jews approved. Twenty percent of respondents said they believe that the U.S.-Israel relationship was very strong, 56 percent said it was fairly strong, 16 percent said it was fairly weak, and 4 percent said it was very weak.
- Anti-Semitism: 64 percent of Jews polled approved Biden’s handling of the anti-Semitism issue while 23 percent disapproved. Biden’s performance on anti-Semitism was approved by 35 percent of the Orthodox, which was better than on other issues, 53 percent of Conservative, 70 percent of Reform, 96 percent of Reconstructionist, 74 percent of secular and 70 percent of non-affiliated Jews.
- Economy: 71 percent of Jews approved Biden’s performance on the economy while 27 percent disapproved.
- Iranian nuclear issue: 55 percent of Jews approved Biden’s performance on Iran nuclear issues while 32 percent disapproved.
- Immigration: 54 percent of Jews approved Biden’s performance on immigration issues while 42 percent disapproved.
- Race: 68 percent of Jews approved Biden’s performance on race relations in the United States while 28 percent disapproved.
- COVID-19: 79 percent of Jews approved Biden’s efforts to combat the coronavirus pandemic while 19 percent disapproved.
The survey also asked about Israel’s relationship with its neighbors and prospects for peace in the region.
Thirty-three percent of American Jews are more optimistic about Israel’s prospects for peace with its Arab neighbors than they were a year ago, 20 percent are less optimistic and 46 percent said there has not been any change.
Of prospects for peace between Israel and Palestinians, 60 percent said not been much has changed compared to a year ago, 25 percent are less optimistic, and 14 percent are more optimistic. The results are similar to AJC’s 2020 survey results.
AJC’s survey was conducted by the research company SSRS, interviewing 1,000 Jews age 18 and older by telephone between March 25 and May 9. The margin of error is plus or minus 4.5 percent at a 95 percent confidence level.
Jewish News Syndicate
With geographic, political and social divides growing wider, high-quality reporting and informed analysis are more important than ever to keep people connected.
Our ability to cover the most important issues in Israel and throughout the Jewish world—without the standard media bias—depends on the support of committed readers.
If you appreciate the value of our news service and recognize how JNS stands out among the competition, please click on the link and make a one-time or monthly contribution.
We appreciate your support.

domain: sociology


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About Darling Harbour
Darling Harbour is situated just on the Western edge of the Sydney CBD, with extensive pedestrian areas, shops, bars, restaurants, and parks. Enjoy a visit to the Chinese Gardens, IMAX theatre or the Sydney Aquarium. Water taxis can take around under the Sydney Harbour Bridge to Circular Quay and the Sydney Opera House.
Stayz has a great variety of holiday accommodation properties in Darling Harbour Sydney, including self service apartments, holiday hotel accommodation, holiday houses and more.If you're looking for accommodation online in Sydney NSW, look no further!

domain: geography


Britain's strengthening recovery will see the economy surpass its pre-crisis peak earlier than expected, according to two leading business bodies, with private-sector optimism now stronger than all other advanced economies.
MARK CARNEY faces probably his toughest questioning so far as Bank of England governor tomorrow when lawmakers will seize on a foreign exchange scandal to press their demands for tighter oversight of the central bank.
Northern Ireland's private sector experienced continued economic recovery last month, according to the latest survey of businesses.
THE BANK of England's forward guidance policy could encourage investors to take too much risk, Bank for International Settlements (BIS) economists have warned.
TOKYO (Reuters) - Japan's economic recovery suffered a blow at the end of last year and the current account deficit ballooned to a record in January, raising fears of a stumble in the world's third-largest economy as activity wilts ahead of a sales tax increase ...


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Over 50 international lawyers, human rights, civil rights and civil society groups and networks say the actions of certain EU member states in response to Snowden's revelations contradict the EU’s stated commitment to democracy, human rights and international law.
India’s neighbourhood is in great turmoil, but New Delhi seems unable to fashion a coherent, balanced, mature and self-confident response to it. In particular, India has dealt with Sri Lanka, Bangladesh, Maldives, Myanmar and Nepal in confused and indecisive, if not wholly inept, ways.
Hagel’s nomination engendered bitter, angry opposition from the moment it was floated as a trial balloon. And the fact that Obama went ahead with the nomination is a good indication that on at least some critical foreign policy issues, Obama is not prepared to allow either the pro-Israeli lobbies or the hard-core neoconservatives, in and outside of Washington, to determine whom he could and could not choose as Secretary of Defense.
Whether or not the day’s events in Egypt constitute a military coup d’etat, the removal from office of President Mohamed Morsi by the Egyptian military portends great excitement but even greater dangers.
While Israel moved away from the far right in last month’s elections, the new coalition is unlikely to alter the occupation. Change may come from divestment campaigns, the new UN recognition of Palestinian statehood, and in the Israeli and Palestinian campaigns of nonviolent resistance.
Our movement changed history. While we did not prevent the Iraq war, the protests proved its clear illegality, demonstrated the isolation of the Bush administration policies, helped prevent war in Iran, and inspired a generation of activists.
Net voor haar abdicatie heeft Koningin Beatrix Prof. Dr. Mirjam van Reisen beëdigd als bestuurslid Adviesraad Internationale Vraagstukken (AIV) en daarbinnen voorzitter Commissie Ontwikkelingssamenwerking; het instituut dat de regering en de Staten-Generaal adviseert over het buitenlandse beleid.
What the civil war in Syria has exposed is that the massive political and social transformation, and real regime change under way is led by people themselves. US military involvement serves only to escalate the destruction.
The Transnational Institute, an Amsterdam-based scholar-activist organization, observed that the response of the Bolivian press is understandable because there have been previous suspicions of outside forces wanting to exercise military control over the natural resources of the Chaco (Tarija) region.


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2018 Honda Civic LX Greenville South Carolina area Honda dealer from 1997 Honda Civic Body Parts, source:breakawayhonda.com
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Buy Spoilers & Body Kits online in Pakistan from 1997 Honda Civic Body Parts, source:pakwheels.com
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2018 Honda Civic Hatchback Sport St Albans WV from 1997 Honda Civic Body Parts, source:mosesbmw.com
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honda civic vti 1997 vtec from 1997 Honda Civic Body Parts, source:philkotse.com
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2010 Honda Civic LX Greenville South Carolina area Honda dealer from 1997 Honda Civic Body Parts, source:breakawayhonda.com
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1999 Honda Civic Front Bumper Cover Install
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Are Sterile Seeds a Threat to Small Farmers?
They escaped from a laboratory in the dusty confines of Lubbock, Texas. But now they plan to colonize the world. If a newly-patented seed technology is on the market by 2005, many of the new millennium’s crops will carry an intentional genetic defect: the seed they produce will be sterile. The U.S. Department of Agriculture (USDA) and co-developer Delta and Pine Land Company call it Technology Protection System (TPS), but to almost everyone else these impotent seeds are known as Terminators.
Research and development of transgenic (genetically modified) seeds is expensive. In 1998, Delta and Pine Land spent over $16 million on its landmark product. Monsanto spent $1.8 billion on similar technology. With Terminator, which is genetically programmed to sterilize its own seed, companies would be able to develop high-value seed without watching their investments being buried, like the proverbial 40 talents, in the ground. How? Farmers will no longer be able to save a portion of their crops’ seed for the next season; they will have to purchase it fresh for each planting. Seed companies see it as protecting intellectual property, allowing them to develop transgene technology in more crops without the risk of losing money when farmers save seeds. The supposed benefit for farmers: higher yields of hardier crops.
But is the trade-off realistic? Larry Breech, chairman of the National Farmers Union environmental committee, doesn’t think so. Saving seed, Breech explains, involves much more than storing it in the barn over winter. Farmers carefully select and condition seed to produce crops adaptable to their own regions’ weather, pest and disease problems and soil. “Good seed from such an operation,” says Breech, “has many of the qualities that [seed companies] are currently making genetic modifications to produce: insect, disease, and drought resistance, as well as food quality.”
Walter Hochman and his son Dale farm 300 acres in Bucks County, Pennsylvania, and they have a constant battle with the bottom line. “The cost of farming stays the same,” Hochman explains, “but the price of crops goes down. Wherever I meet other farmers, they all say the same thing: They’re just barely making it.”
This spring, the Hochmans will plant Monsanto’s “Round-up Ready” soybeans (genetically modified to be resistant to Monsanto’s own Round-up herbicide). Purchase of the seeds comes with a limited license to produce a single commercial crop. Using the seed for anything else is strictly prohibited, so the Hochmans won’t save any for replanting.
Farmers routinely save seed from their wheat and oat fields, but not for long, if Terminator comes to dominate the market. “They’re just putting the small guy out of business,” says Hochman, whose family has farmed the land since 1935. “They’ve got us over a barrel.”
Dr. Harry Collins, vice president of technology transfer at Delta and Pine Land Company (D&PL), disagrees. “Farmers will always have a choice. If they don’t want TPS, they can buy seed without it.” But will seed companies continue to provide conventional seed when Terminator guarantees a greater return? Collins says that D&PL will produce conventional seed as long as farmers want it, but there are no guarantees.
And farmers may feel the economic squeeze at both ends. European consumers don’t trust transgenic crops, and their reluctance to purchase them cost the U.S. two million tons of corn targeted for Spain and Portugal last year. Japan buys one-third of the United States’ feed grain exports, but because Japanese consumers also resist purchasing transgenic crops, the country’s Ministry of Agriculture, Forestry and Fisheries is considering biotechnology labeling. Tom Sleight, executive director of the U.S. Grains Council, says the U.S. is “trying to help Japan accept safeguards that are already in place.”
Environmental concern over Terminator has sent ripples through grassroots environmental groups, scientific communities and non-governmental organizations throughout the world. Will Terminator provide food for developing countries—as seed companies proclaim—or drive indigenous farmers, who couldn’t afford to buy new seed every year, out of existence? Will unexpected allergic reactions trigger health problems? Will the use of antibiotics to “switch on” the Terminator gene result in lingering effects on ecosystems or human health?
Separating fact from fiction is difficult, and consensus is lacking. But one myth can be laid to rest: Sterility does not spread. Planting Terminator crops will not wipe out nearby plants. In fact, USDA touts Terminator as a means to prevent transgene escape and spread.
Dr. Melvin Oliver, USDA scientist and co-inventor of Terminator, explains. “Rice could be a target for TPS, and it has a close relative that is a real nuisance: a weed called red rice. Contamination of rice fields with red rice causes major problems for the industry. Farmers would love to have a “Round-Up Ready” rice so they could kill off the contaminating red rice and leave the normal rice untouched. However, the fear of producing a Round-Up-resistant red rice has paralyzed this effort. TPS could solve this problem.” Because Terminator’s built-in self-destruct gene would exist in the rice pollen, red rice infected with the herbicide-resistant gene would theoretically produce only sterile seed.
Oliver stresses that the process “is designed for self-pollinating crops—in particular cotton, wheat and soybeans. In each of these crops, the spread of pollen to neighboring crops is extremely limited—less than one percent. Loss of habitat is not a real possibility. The natural seed bank in the ground is enormous and is unaffected by TPS.”
Martha L. Crouch, associate professor of biology at Indiana University, cautions that “Terminator genes may fail to produce toxins because of a phenomenon called gene silencing.” In other words, introduced genes don’t always do what they are supposed to do. Suppose that in a few of the herbicide-resistant rice plants, the Terminator gene failed to be activated. Red rice infected by these plants would produce viable seed. While chances of this occurring are minimal, one infected red rice plant producing viable seed would give its offspring an herbicide-resistant advantage.
To date, the technology has been attempted only in cotton and tobacco plants. No Terminator crops have yet been field-tested. USDA, D&PL and Monsanto (whose bid to purchase D&PL has been accepted by D&PL shareholders and awaits Justice Department approval) will continue research before Terminator is expected to hit the market in 2005. USDA, in response to widespread criticism of its role in partnering with D&PL, is currently revising its research financing policies to include input from critics of transgenic technology.


text:
Valentino Garavani Shoulder Bag Black Cross body-väskor
27 750 kr
eller 12 avbetalningar 2 659,38 kr
The versatile crossbody bag from Valentino Garavani, manufactured in Italy, combines an understated and chic look. Made of black Saffiano leather, the crossbody bag is an enduring accessory with a sturdy texture. With gold colored metal detailing, the crossbody bag is a classy centerpiece for any style. The contents of the bag can be stored straightforwardly and securely in the main pocket. Order and separate protection are ensured by two practical additional pockets.
- Fabricated from black Saffiano leather
- Bag interior consists of high-quality, red leather
- Stylish look, thanks to gold colored metal details
- Detachable handle made from classy metal chain for additional flexibility and good grip when carrying (approx. 77 cm)
- Detachable and adjustable shoulder strap made of robust leather for good grip as well as a variable and individualized fit (approx. 96 cm to 116 cm)
- Closed with flap and timeless magnetic button
- One main pocket and two additional internal pockets
- Supplied with protective dustbag
- Dimensions (W x H x D): 20 cm x 16 cm x 8 cm
- Weight: 835 g
- Made in Italy
Här får du viktiga tips om hur du sköter om din väska.

domain: design


text:
Maps that help people visualize ocean currents can be used to address environmental problems such as oil spills, for search and rescue missions, or even to plan military operations. These maps are made possible through the work of physical oceanographers such as A. D. Kirwan, Jr., Mary A. S. Lighthipe Chair in Marine Studies and director of the Physical Ocean Science and Engineering Program at the University of Delaware’s College of Marine Studies.
On Thursday, August 21, at 7:00 p.m., at the College of Marine Studies’ campus in Lewes, Kirwan will discuss his research in a talk titled “Where Do Currents Come from and Where Do They Go?” Kirwan’s presentation is part of the Ocean Currents Lecture Series, which is held monthly at the Lewes campus through September.
In his presentation, Kirwan will give a brief description of the forces that generate ocean currents. In addition, he will share the results of his research in the Gulf of Mexico and Monterey Bay, California, to show how ocean current maps are generated.
In the Gulf of Mexico, the currents are driven by very large eddies having diameters that are on the order of 100 miles or more. Observations of current velocity at discrete points in time are obtained by satellites, aircraft, ships, and buoys. Scientists then use this information in a computer model. As observations are updated, the model is modified accordingly.
“The processes that govern the motion of water in Monterey Bay are completely different from those in the Gulf of Mexico,” says Kirwan. “For example, the eddies are much smaller — approximately one mile in diameter. In addition, the water motion is complicated by variations in the bottom topography as well as strong winds and tides.”
The rapidly changing currents in the Monterey Bay region are measured by high-frequency radar, which has the capability of measuring ocean currents at numerous locations. Physical oceanographers fill in any spatial gaps through a process called “objective mapping” to estimate current velocity.
A member of UD’s faculty since 1999, Kirwan earned his doctorate from Texas A&M University in 1964 and his bachelor’s degree from Princeton University in 1956. His book Mother Nature’s Two Laws: Ringmasters for Circus Earth, published by World Scientific, introduces nonscientists to thermodynamics and explains how this science can be used to understand issues such as global warming and the practicality of electric cars. Kirwan also has written more than 70 peer-reviewed publications.
The lecture will begin at 7:00 p.m. in Room 104, Cannon Laboratory, at the Hugh R. Sharp Campus, 700 Pilottown Road, Lewes. The hour-long talk will be followed by light refreshments.
While the lecture is free and open to the public, seating is limited and reservations are required. To reserve your seat, please contact the college at (302) 645-4279.


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A Greggs super-fan has shown her appreciation for one of its products - by getting it tattooed on her leg.
Tattoo apprentice Beth Kweeday, 23, got inked with a design of one of its vegan sausage rolls.
Beth visits the bakery several times a day, with her obsession leading to her declaring her love for Greggs in a unique way.
The artwork was carried out by colleague Rachel Baldwin, 35, who jokingly suggested she give Beth the tattoo after noticing her lunch habits.
The pair, who work together at Bold as Brass tattoo studio in Liverpool, designed it together, before Rachel tattooed vegetarian Beth on October 21.
Now in the healing process, Beth said she “couldn’t be happier” with the outcome of her latest ink.
Beth said: “All my colleagues in the tattoo shop have a running joke about how often I buy food from Gregg’s.
“When Rachel suggested the tattoo, I was on board straight away – a lot of my tattoos are quite serious so it’s good to have a jokey one too.
“I definitely wouldn’t say no to another Gregg’s tattoo – it's opened a door for me now.
“It’s safe to say I’m a Gregg’s super-fan!”
Rachel, who spent an hour inking the pastry on Beth’s leg, said: “The tattoo idea came about because Beth goes to Greggs around five times every day.
Sign up to the StokeonTrentLive newsletter for all the latest news by clicking here.
“She loves all the vegan options they have so I suggested we solidify her love.”


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The proposed NSD-ISS staging system for Parkinson's disease, focusing on neuronal α-synuclein pathology, aims to enhance trial design and drug development.
A published paper from patient, research, and industry leaders proposed a new staging system by which Parkinson disease (PD) is defined, using neuronal α-synuclein (n-αsyn) pathology, considered a hallmark for the disease, instead of clinical symptoms. Otherwise known as the neuronal α-synuclein disease integrated staging system (NSD-ISS), this system is currently intended for research use only, with the goal to enhance trial design and improve drug development.1,2
The NSD-ISS integrates 2 core biomarkers: aggregated αsyn and dopamine dysfunction. The staging system starts with stages 0-1, which occur without symptoms and are defined by the presence of pathogenic variants in the SCNA gene (stage 0), S alone (stage 1A), or S and D (stage 1B). Stages 1 and 2 are based on objective biomarkers, while stages 3-6 require these biomarkers and progressive motor and other nonmotor symptoms.
Lead investigator Tanya Simuni, MD, FAAN, director of the Parkinson’s Disease and Movement Disorders Center at Northwestern University, and colleagues published the new framework in The Lancet Neurology; however, it would not have been possible without previous research published in 2023. Funded by the Michael J. Fox Foundation, the analysis, considered the largest for an α-synuclein seed amplification assay to date, further validated its role in the biochemical diagnosis of PD. In a cohort of more than 1100 participants, the sensitivity of the assay for PD was 87.7% (95% CI, 84.9-90.5), with even increased sensitivity in sporadic PD with typical olfactory deficit (98.6%; 95% CI, 96.4-99.4).
In stages 3-6, the severity of functional impairment defines each progressive stage. “Although this staging system is grounded on the neuronal α-synuclein disease biological framework, establishing the degree of functional impairment using a data-driven approach is necessary for therapeutic development and other applications of the NSD-ISS,” the study authors wrote. In these stages, functional impairment qualitatively is described as slight, mild, moderate, and severe, in ascending order.
In the paper, the authors note that n-αsyn disease is a continuum, and that an individual in a given stage is presumed to have passed through all preceding stages, beginning with stage 1A. Although a transition from stage 1 to stage 2 may not be observed in a patient, depending on the timing of assessment, the NSD-ISS framework will enable studies to investigate the timing for progression from each stage to the next and the key additional biological determinants that might influence the rate of progression.
Although early in its infancy, the group of investigators believe that data derived from several prominent rating scale assessments in prospective cohort studies and clinical trials will be used to define thresholds for stages 3-6, similar to the Huntington’s disease Integrated Staging System. In addition, the Movement Disorders Society-Unified Parkinson’s Disease Rating Scale Parts I and II, widely used to measure functional impairment, would be considered a starting point; however, investigators expressed qualms about its limited sensitivity to detect changes in function in early disease stages.
The paper also acknowledged that individuals with n-αsyn might have a range of clinical syndromes, and that in most cases, these syndromes will overlap, and contributions from motor and non-motor features will produce a cumulative effect on functional impairment. Clinical presentations arising from n-αsyn disease include n-αsyn-driven motor parkinsonism and cognitive impairment–currently diagnosed as PD, PD dementia, or dementia with Lewy bodies based on clinical diagnostic criteria. REM-sleep behavior disorder, dysautonomia, and other neuropsychiatric symptoms may also predominate as well.
"Although the NSD-ISS provides a unifying biological definition and staging, recognition of clinical syndromes is important to guide symptomatic management, family support, and education," Simuni et al wrote.2 "Another important implication of the biologically based framework of the NSD-ISS is that a clinical diagnosis of prodromal Parkinson's disease, Parkinson's disease, Parkinson's disease dementia, or dementia with Lewy bodies is neither sufficient nor necessary for a neuronal α-synuclein disease diagnosis."

domain: biology


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#Star Wars #Harrison Ford
Harrison Ford Won’t Answer Star Wars Questions [x]
Patton Oswalt (fellow W&M alum*!) is guest-starring on Parks & Rec and gives a magnificent (improvised!) Star Wars VII-inspired filibuster rant.
*Speaking of this, I made the hilarious discovery that he’s in Bruce Hornsby’s video for “The Valley Road” which was filmed in the ‘Burg. He’s the one clapping and duckwalking at 4:08.#Star Wars #Nothing but Star Wars #Give me those Star Wars #Don't Let them ennnnnd
In honor of Dad, I was going to post some pictures of his Star Wars collection (I inherited his iPad and, omg, you would not believe how organized he was in terms of his lists and photo documentation), but I suddenly remember that this video existed! Some of my brother’s college friends decided to film themselves driving from Orange, CA to Orange, FL and stopped at my family’s house for the night. One of my dad’s absolute FAVORITE things in the world was to give people tours of his collection and he could always take people poking a little fun at his expense. Jump ahead to 3:00 or so in the video.
P.S. His eBay handle was SW_Dan55 (or somesuch), totally missing the fact most people would think he meant “Single White Dan,” but that’s the source of our “Star Wars Dan” nickname.
P.P.S. One of the hardest things about his passing has been deciding what to do with his beloved collection. There are pieces I know we’ll keep because he loved them or we loved them, but we’re still working out what will happen to the rest of it.#family #Life #Dad #Star Wars
A long time ago in a galaxy far, far away …
(Old school Star Wars requested by » soulbind)
(via inconstante)#star wars
#Star Wars #Well done everyone!
Star Wars Posters by Pete Ware
#The Empire Strikes Back #Star Wars
“ Some people call it science fiction. I don’t even consider it science fiction; I consider it a fairytale. Fairytale is the environment… you can, literally, do anything. And if I believe it while I’m filming it, the audience tends to believe it too. ” —Irvin Kershner, Director: Star Wars: Episode V
Carrie Fischer and Harrison Ford on the set of Empire Strikes Back
(via karadama)#Star Wars #My first OTP #Lady Hero
#STRONG WITH THE FORCE #Star Wars
Bandeiras das casas da cultura pop no estilo de Game of Thrones.
#Brooooomance nothing but brooooomance #Star Wars #Han Solo #Luke Skywalker
“Together again, huh?”
“Wouldn’t miss it.”

domain: entertainment


Lakeside Machine is proud to announce
the availability of the only belt-fed 17HMR firearms in the world! As an
option we are offering all our M2 series miniatures in this new cartridge.
We can build your M2 miniature to be convertible from 22 magnum to 17 HMR. We
would be happy to build your M2 with BOTH barrel
assemblies. If you already have an old M2 Tippmann we can fit your gun with our 17
cal barrel assemblies for the conversion. You must forward your receiver to us
for fitting and head spacing for proper function.
Barrel conversions are $375.00 completed and fit to
your gun with a new barrel carrier handle assembly. A new gun ordered in just
the 17 HMR cal is only $100.00 more than the 22 magnum units.
M2's ordered with both 17 and 22 barrels are $350.00
more than the original cost of a 22 magnum M2.
Email us at firstname.lastname@example.org
for more details.


text:
Confidence is really your ability to access empowerment in all areas of your life. It’s the opposite of victimhood, and that’s why it’s so liberating. Empowerment doesn’t come from others, it comes from within, and confidence is the same.
It's easy to forget that we are all perfect in our own design. Sometimes we muck it up with habits and choices that do not serve us.


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Long stay travel insurance
Finding travel insurance cover for longer trips can often be tricky as many companies only provide basic cover. With TravelInsurance.co.uk, you are bound to find a policy to suit you.
As travel insurance specialists with over 10 years of experience, we have developed a wide range of policies to choose from. Our backpacker travel insurance provides cheap, comprehensive cover for trips of up to 18 months in length.
Whether you’re travelling on a gap year, going for an adventure or just living and working abroad, come to Travelinsurance.co.uk for a competitive long term holiday insurance quote.

domain: travel


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SOCASTEE (WBTW) – Socastee High School named Derrick Hilton the new head coach of the boys basketball team on Tuesday.
Hilton is familiar with the Braves, as he used to play basketball for Socastee when he was a student there. Hilton played under Dan D’Antoni and went to the state championship game in 1998.
Hilton is a graduate of Coker College. He has previous coaching experience at St. James and Loris. Over the past nine years, he served as an assistant coach at Socastee.
Hilton says he is looking forward to what next season holds for his new team.
“Play hard and play together,” Hilton said. “That’s our goal for next year.”


Case Study Overview
Premier House is a 1960‘s concrete frame office building which was converted into 119 luxury residential apartments. The development had 13 floors so the specified products within the floor build-up had to have strong acoustic sound reduction properties as well as a minimal height build-up.
The client was originally considering a wet underfloor heating system but was having difficulties in finding one which allowed for minimal height build up. So, in we stepped and proposed the ThermoSphere Foil electric underfloor heating system as a low build up alternative.
This solution was a completely dry installation and had a build-up of only 47mm. This meant that the client could maintain perfect room heights no matter the constraints of the structure. Importantly the acoustic improvement surpassed the building requirements required by building control.
We were able to provide a complete, fast-track solution, to an extremely tight deadline. We went above and beyond the requirements to supply a total floor buildup tighter than originally planned saving the client valuable time and resources.


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One of the allures that drew you initially to North Carolina was its four “full” seasons. The distinct and enjoyable weather patterns for each season now that you’ve opted to relocate to Rocky Mount are a major factor in many choosing to call NC their home. Of those seasons, there may be none prettier than the Fall. Couple that weather with the changing of the colors coinciding with the autumn season and it is the perfect time to spend outdoors. That along with your great location at Belmont Lake Preserve gives you countless incredible options for North Carolina Fall Hikes that all showcase the true beauty of our state.
Sure, in a perfect world, we would all like the chance to get away for a weekend. Soak in the brisk fall air and marvel at the spectacular oranges, reds, and yellows, that fill the natural scenery. But in reality, many of us don’t have the time or money for this type of weekend excursion. Thus, these North Carolina Fall Hikes that follow are ones that can easily be accomplished round trip on the same day.
North Carolina Fall Hikes Where the Beauty Matches the Heights
Obviously, some of the most breathtaking points in all of North Carolina are those from its highest points, the mountains. As you can imagine, with all the colors and natural beauty of the season these are even more spectacular each Autumn. While these may not be the longest or most strenuous walks, the following North Carolina Fall Hikes will certainly give you a view that screams, “I made the right choice moving here.”
Jomeokee Trail, Pilot Mountain
Speaking of shorter trails, this may be the shortest on our list. However, at just under one mile, the view from the Jomeokee Trail makes up for any distance. Of any of these North Carolina Fall Hikes, this one may be the best to enjoy even when. alone. With numerous “nooks” and rocky “hideaways,” you may literally gasp at the gorgeous view from here.
Referred to at the website “Only in Your State” as a “fairytale year-round,” Craggy Gardens is another amazing entry to our North Carolina Fall Hikes. This one-and-a-half-mile trail is accessible from a parking lot just off the Blue Ridge Parkway. There are two separate amazing overlooks on this hike that give you a “peek” from two of NC’s highest “peaks.”
When locals hear the name Whiteside Mountain, they immediately suggest you enjoy this entry to the North Carolina Fall Hikes in the late fall. This is one of two points in the year that you can see the amazing “Shadow of the Bear.” All that aside, the incredible surroundings you will pass by on the 2.5-mile walk along the Whiteside Mountain Trail will take you to a stunning view from the cliff at its end.
Talk about an awesome view. Now, let’s talk about Chimney Rock, the next of our North Carolina Fall Hikes. To make it to this incredible point, one may first ask how you are climbing stairs or steps. Why? Well, this is a 500-step climb to its top, but once you are there it is said the awe-inspiring panoramic views you see can reach an almost 75-mile radius.
Lower Cascade Falls at Hanging Rock State Park
Ok, so this is another of the North Carolina Fall Hikes that is not the longest of walks. Actually, it’s only about a half of a mile, but once you reach the end, you’ll probably want to stick around and enjoy a bit. Once you reach the trail’s end here, you will find a spectacular waterfall that is surrounded by rock formations that combined with the soothing sounds of the rushing water is about as pleasant as one could imagine.
Flat Laurel Creek
The last of our North Carolina Fall Hikes is one that takes you on an equally amazing, but somewhat unique 2.5 miles. To look at the surroundings, one may think for a second that they were somewhere in the mid-western part of the country. However, any feeling of that should suffice once you’ve entered the spruce-fir forests. This trail actually lies under both Black Balsam Knob and Sam’s Knob and can easily lead to a nearby waterfall that lies on the Creek.
You’re Never Too Far from the North Carolina Fall Hikes when You’re At BLP
Through all your research and preparation for the move to the Belmont Lake Preserve you have become familiar with “Lifestyle Redefined.” Likewise, the “Location” section at belmontlakepreserve.com reminds you that when you are at BLP ” you are never too far from” all the great sights and places of the state. This couldn’t be truer as you set out to enjoy the gorgeous NC fall season and all the surrounding beauty in which it entails.


The Airports Authority of India (AAI) will soon get land from the Tamil Nadu government for the expansion of the Madurai and Tuticorin airports. The additional land will be used for expanding the runways, constructing additional terminal buildings to cater to the increasing passenger traffic, the air traffic control tower and other facilities. The Tamil Nadu government has nearly completed the proceedings for the land acquisition such as holding a public hearing and issuing a preliminary notification. It will now shortly issue an acquisition notice for the purpose. In Madurai the government will acquire 615 acres of land while in Tuticorin it will acquire 586 acres.
Tagged with: Madurai and Tuticorin airports


it's never too late, you're never too bad, never too old, never too sick to start from scratch and begin again.-choudhury
I promise that I'll be back soon...a weekend of neighborhood (bonfire!) festivities and personal (anniversary!) festivities has grudgingly given way to a week full of audition tour prep, Inspector-related events and chamber music performances. (!) (?) Lots to do, and correspondingly little time to write about it.
You'll hear from me shortly, from the road. Cheers!


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ATLANTA — Three Henry W. Grady High School students were arrested after allegedly sexually assaulting a 14-year-old classmate at Piedmont Park last week, according to Atlanta police.
The alleged attack happened May 8 when the victim skipped class with a friend and two other boys, according to the report.
According to the police report obtained by Channel 2 Action News, the student told officers she went to her first-period class. The student said she talked to her friend about skipping second period and going to the park. The friend invited two other boys to join them.
According to the report, the students ended up at the family bathroom near the pool, where two of the boys tried to get the girl to perform sexual acts.
The girl told police that she repeatedly told the boys to stop, but they insisted, with one of the teens eventually raping her.
The boys eventually left, according to the report, and took the girls’ bag and cellphone with them.
Police were called to the school after another student alerted a teacher to the alleged sexual assault.
The victim was taken to the hospital. The three male students were arrested after police were able to identify them.
The students, who were not publicly identified, are charged with one count each of false imprisonment, aggravated sodomy and criminal attempt, police reports show.
An Atlanta Public Schools spokesman said district officials are aware of the alleged incident and are cooperating with Atlanta police.
© 2020 Cox Media Group


text:
Jimi Hendrix was many things: a superstar, a rebel, a hero, an innovator. But first, he was a boy named Jimmy who loved to draw and paint and listen to records. A boy who played air guitar with a broomstick and longed for a real guitar of his own. A boy who asked himself a question: Could someone paint pictures with sound?
This a story of a talented child who learns to see, hear, and interpret the world around him in his own unique way. It is also a story of a determined kid with a vision, who worked hard to become a devoted and masterful artist. Jimi Hendrix--a groundbreaking performer whose music shook the very foundations of rock 'n' roll.
Coretta Scott King Honor for Illustrator "This book is likely to fascinate older children and reluctant readers who might be familiar with Hendrix’s music, and could easily be tied into art and music curricula."—School Library Journal, starred review "The author—an artist and clinical social worker—lucidly demonstrates that a path to creative excellence is not only possible for young people but self-actualizing."—Kirkus, starred review "Valuable lessons underlie newcomer Golio's account of Hendrix's life: important work can be done by young people; artistry develops slowly, through careful work; and surroundings that appear hostile to creativity can just as well nurture it."—Publishers Weekly —

domain: library


text:
(AllHipHop Rumors) Gucci Mane has a new book on the way and he’s telling his life. And a big part of his life is when he was a accused of murdering some dudes that ran up in his house and tried to rob/kill him. Whatever they tried, they failed. Gucci bodied one of them after they used a woman to set him up. Well, it was never proven (to my knowledge) that Young Jeezy had anything to do with it, but it sure was all over the streets that he did. Well he tells all in his new book “The Autobiography of Gucci Mane.”
There are about 4--5 short chapters dedicated to the beef with Jeezy and it is laid out very methodically. He talks on the conditions leading up to the murder, his incarceration, and the press runs he did afterward where he named Jeezy specifically. In the book, he talks about how there were a lot of small misunderstandings and how Gucci was eventually detained and questioned by the FBI regarding the BMF case. He says his response was, "Lawyer" and ”I aint got nothing to say. Look I'm tired. I need to go to sleep."
There is a poem/rap that he wrote in jail in isolation at DeKalb County Jail.
"I always dreamed to be a rapper/Just like Big Daddy Kane/But all I got was jealousy/since I took my daddy's name" His dad was also called Gucci.
He talks more about Jeezy:
"I was angry. Directly or indirectly this guy had put me in a situation where I had to fight for my life in the streets, and now I was going to be fighting for my life in the courts. Meanwhile he was out there enjoying all the success of his debut album. As the days turned to weeks and weeks turned to months I sat in solitary, going over how everything had played out. How had this good situation turned out so bad?"
I wonder what Jeezy will say.
“The Autobiography of Gucci Mane” comes out Sept. 12.


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AEGEE-Yerevan members are not only active citizens involved in various activities, but also young and enthusiastic guys who love playing football once in a while.
On the 4th of March AEGEE Yerevan members, well, the boys, to be exact, took part in a football match. It was even more interesting to watch the game since the members of both teams were from AEGEE Yerevan. Naturally any result would be our win, but the two teams played really well leading to a drawn game. Now let’s find out what the guys think about that historic match.
1.Do you consider yourself a football fan? If so then what is your favorite team?
Aram Janazyan: I can go days without watching football, and I don’t feel bad about it. But sometimes I feel like hanging out with my friends and watching a great football match, especially the national team of Armenia, Brasil and Italy, also the matches of football clubs.
Mikayel Minasyants: I’m not such an emotional fan. You know just a fan, not a fanatic. But I have my favorite team and it is FC Real Madrid. I fell in love with this team from my early years. I can’t explain that, I just love this team and all.
Arthur Grigoryan: Of course I’m a football fan. I have been playing football since I was a child and I like to watch football matches. My favorite team is Manchester united (Red Devils).
Suren Gharibyan: Yes and my favorite team is AS Roma.
Ararat Mkrtumyan: I am a football fan and I’m the most devoted fan of FC BARCELONA.
Armenak Minasyants: Yeah, I am really even not a fan but a fanatic, my most favorite football club is Manchester United and of course my most favorite national team is Armenia.
2.What was the best part of this game? Something that you will never forget.
Aram Janazyan: I think that in football for any player the best moment is when your team scores a goal. There was a moment that I will never forget. I was a goalkeeper and the ball hit my stomach and it bounced back. To tell you the truth it was painful but I kept my cool and everything turned out to be great.
Mikayel Minasyants: Mmm… I remember a moment, when Suren made powerful kick and Aram just jumped away, to avoid the ball. It was too funny. For me it was the best moment of our incredible game.
Arthur Grigoryan: All the game was very interesting, and I’ll never forget it.
Suren Gharibyan: I will not forget our fans, our supporting girls 😀
Ararat Mkrtumyan: Saves of Miqayel Minasyants as a goalkeeper.
Armenak Minasyants: I guess the toughness of whole game as none of the guys was trying to retreat….everybody was playing on his maximum and was trying to show his best skills. It is a bit uncommon and remarkable for friendly matches.
3.Would you like to play again? If yes, with what team?
Aram Janazyan: A match with Saudi Arabia national team, since we have chances of winning them 🙂
Mikayel Minasyants: Yes, of course. It will be a pleasure to play with our guys again. You know, team is secondary; there is no reason to see differences in players. We are playing for fun and for our great and lovely girls. He plays good, and he does not. No. In AEGEE we all are in one team, and even when we aren’t in the same team, we are in the same team.
Arthur Grigoryan: I would like to play AEGEE-football every week, cause it’s a good idea to spend a great time with AEGEE-ans 🙂
Suren Gharibyan: Yes I would like to play again, for example vs another NGO.
Ararat Mkrtumyan: Sure I’d like to play again, no matter what team it would be.
Armenak Minasyants: No doubt I would and I guess all our guys will join me. The opponent is not important, but it would be nice to have a match with either another NGO or maybe with our girls, for example a match of mixed teams.
4.What was the first thing you did when you got home after the match?
Aram Janazyan: I took a shower, had a dinner, watched TV and went out to run some errands.
Mikayel Minasyants: I took a shower.
Arthur Grigoryan: After the football match I went to swimming pool and sauna for relaxing and to a swimming class.
Suren Gharibyan: I Drank a lot of water 😀
Ararat Mkrtumyan: I went to sleep 🙂
Armenak Minasyants: I took a shower and started to massage my knees, as I have injured both of them.
5.If you could become one of the famous football players just for a couple of hours, in order to win the game who would you choose?
Aram Janazyan: Ronaldinho.
Mikayel Minasyants: Roberto Carlos or someone else who plays defender position and has powerful and freaky shots.
Arthur Grigoryan: I would not like to be a famous player at that football match, because we won that match without it, only by our hard work.
Suren Gharibyan: I will choose Francesco Totti.
Ararat Mkrtumyan: Andrés Iniesta Luján (FC Barcelona).
Armenak Minasyants: Of course Wayne Rooney.
6.Would you like to make a compliment to any specific team member? Somebody who played outstandingly well?
Aram Janazyan: Arthur Grigoryan, Tigran Hakobyan, and Suren Gharibyan from another team.
Mikayel Minasyants: We all played well. Especially…. I
Arthur Grigoryan: It’s my own opinion, but I want to say that the best player of the match is Suren Gharibyan. We have been playing football together for many years and obviously he is a good forward.
Suren Gharibyan: All of us.
Ararat Mkrtumyan: In my opinion Miqayel Minasyants was the player of the match.
Armenak Minasyants: A bit difficult thing to do as football is definitely a team game, but anyway, not only one, but several people; of course Mike, who has outstanding performance as goalkeeper and Suren for his Francesco Totti style shots from the half of the field.
7.Did you like the match? What impressions do you have?
Aram Janazyan: We had great fans, which supported the teams actively; we were in a great mood and had a friendly atmosphere.
Mikayel Minasyants: As I mentioned, the game was incredible and stunning. I haven’t played football for about two years but I get great emotions and I was boiling in my own endorphins.
Arthur Grigoryan: Of course I did. It was very nice to hear the voice of our fans (AEGEE-ans) and it gave us a lot of energy for playing and for our victory.
Suren Gharibyan: I liked it a lot and got unforgettable impressions
Ararat Mkrtumyan: I liked the match and it was well organized, “well played”. Everything was GOOD.
Armenak Minasyants: Match was really interesting and the playing time passed away too fast…..just 60 minutes in 1 second. Anyway, I was totally impressed not as much with the match but the superb support which our girls brought with them to the hall. Really it was perfect to play in front of them.

domain: hobby


text:
November 28th, 2014
Medium: iPhone Notes
I find myself adrift in this tepid wasteland. Fear guides my actions in an art so fine, so subtle. I can't finish this as I couldn't those that preceded it. Whatever I currently am is a mere shadow of something so much less than glorious. But to be back there would be the greatest of achievements. A peace after a fight that'd never end.


text:
The fact that ME/CFS has an infectious onset in many cases, and is associated with abnormalities of cellular immunity, raises the question of whether people with the illness are at an increased risk of developing cancer. There is certainly no definitive evidence that this is the case – principally because the large-scale epidemiological studies needed to establish a link have not been conducted. Yet, over the years, there have been intriguing, if inconclusive, hints that there may be an association between ME/CFS and cancer. For example, a survey of deaths from a memorial list in the USA found that one-fifth of the ME/CFS patients listed had died of cancer. And an analysis in 1998 of data from the Nevada Cancer Registry, found the incidence of non-Hodgkin lymphoma and primary brain tumours to be comparatively higher in two northern Nevada counties where well-documented outbreaks of CFS had occurred between 1984 and 1986.
The existence of such fragmentary evidence, plus the biological plausibility that the immune abnormalities or infections found in ME/CFS might increase the cancer risk, led researchers at the National Cancer Institute to undertake a large case–control study (published in Cancer, 2012) among elderly adults in the United States, using linked data from cancer registries and Medicare claims files. The advantage of this experimental design is that very large sample sizes can be obtained, a crucial step if valid conclusions are to be drawn about the connections between highly heterogeneous diseases such as cancer (which contains many different types of tumour at many different stages) and ME/CFS (which is most probably a diagnostic “black box” containing different clinical groups of patients).
The National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) program provided the cancer data from registries across the US, with “cases” defined as people aged 66 to 99 years with first cancers from 1992 to 2005. The occurrence of “CFS” was assessed from Medicare claims using ICD codings. For analysis, a combined SEER-Medicare data set was created electronically to allow the link between cancer and ME/CFS to be explored.
Overall, the presence of CFS was similar in cancer cases and controls (0.5% in each). The table shows that CFS was not associated with cancer overall, but was associated with a significantly increased risk of non-Hodgkin lymphoma (NHL; odds ratio 1.29). Looking at the subtypes of NHL, CFS was associated with diffuse large B cell lymphoma (odds ratio 1.34), marginal zone lymphoma (odds ratio 1.88), and B cell NHL not otherwise specified (odds ratio 1.51). There were also significant associations initially between CFS and a few other cancers, including cancers of the pancreas, kidney, and breast, but these became non-significant after correction for multiple comparisons.
While the finding that the overall cancer risk was not increased is encouraging, what might explain the increased risk of NHL in people diagnosed with CFS in the USA between 1992 and 2005? Well, we can only speculate, but the researchers point to the immune abnormalities (some shared with cancer) that have been observed in ME/CFS patients – including increased immune activation, reduced natural killer cell activity, and the presence of autoantibodies – and to some of the viruses and bacteria that have been implicated in the development and maintenance of the illness. Since both immune disturbances or viral infections have been implicated in the development of diffuse large B cell lymphoma and marginal zone lymphoma in other contexts, the authors suggest that similar associations are at least plausible in ME/CFS. However, they caution that the study was limited to people aged 66 years and older, so that the findings may not be generalisable to younger (non-elderly) populations. Furthermore, they warn against any direct interpretation or application of these results in a clinical setting; as they say, “We could not estimate the absolute risk of non-Hodgkin lymphoma associated with CFS, but the risk is likely too small to affect the clinical management of patients”.