text:
Online Dictionary: translate word or phrase from Indonesian to English or vice versa, and also from english to english on-line.
Hasil cari dari kata atau frase: hafnium(0.01204 detik)
Found 2 items, similar to hafnium.
English → English (WordNet)
n : a gray tetravalent metallic element that resembles zirconium
chemically and is found in zirconium minerals; used in
filaments for its ready emission of electrons [syn: Hf,
atomic number 72]
English → English (gcide)
hafnium \haf"ni*um\ (h[a^]f"n[=e]*[u^]m or h[aum]f"n[=e]*[u^]m),
A metallic element of atomic number 72 present together with
zirconium to the extent of 1% to 5% in zirconium minerals. It
is a poisonous, ductile metal with a brilliant silver luster,
has an atomic weight of 178.49, and has a high melting point
(2227[deg] C). It is used in nuclear reactors, and
incandescent lamps as a scavenger of oxygen and nitrogen. See

domain: chemistry


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|Reviews for 3 Alarm Booty Call|
| jennylovescastle chapter 1 . 2/8/2016
i like it. Sweet funny and i wish there would be to it :) Thanks for writing.
| Guest chapter 1 . 5/11/2013
| Queen Elizabeth chapter 1 . 1/5/2013
Simply adorable! loved the dialoge
| Telepathica chapter 1 . 12/14/2008
Cute; that word just about sums it all up. I enjoyed the dialouge...kept me interested. Well done! I love MulderScully fanfiction especially when done right. This one was done right, so I loved it. "Scully, I was groping you, I shouldn't have to warn you!" I liked that line. Special Agent Dana Scully isn't all that spontaneous, now is she?
| SiriusBlack4Ever chapter 1 . 8/18/2008
Adorable. I love that you've made the characters still seem in-canon here, despite the fact that this delves a bit more into their "relationship" than the series did at this point. Very funny, and very cute. I can literally imagine this scene being played out in my head as if it were part of an episode. Great work - this really makes me miss "The X-Files." :)
| missscareall chapter 1 . 7/27/2008
| Agentsassy08 chapter 1 . 6/29/2008
that was funny. hahaha :P nice job
| ruths chapter 1 . 6/15/2007
I don't usually read shorts like this, but you so totally nailed their rhythm that it's become one of my favorite stories! Fantastic!
| Elisa chapter 1 . 6/4/2007
Aw, this is so cute! Why don't you have more reviews?
| fayzalmoonbeam chapter 1 . 5/31/2007
That was funny, sweet and sexy - and I could hear the dialogue from David and Gillian too. Great stuff :)
| CrazyMaryT chapter 1 . 5/26/2007
Don't care if it's fluff. Loved it. I think the whole tone is very playful just like I always thought they were. Thank you for sharing.
| go.suck.on.a.lemon chapter 1 . 5/21/2007
*fans self madly* Funny and hot! Marvellous combination, props!
| Missing Linka chapter 1 . 5/21/2007

domain: entertainment


text: Patient Online Project Patient Online Project Do you struggle to get an appointment with your GP? Did you know that you could order repeat prescriptions online? Would you like to access you medical records 24 hours a day, seven days a week? Right now less than 15% of patients in Hackney are registered to Patient Online Services. We believe that those patients who would most benefit from accessing services online are often those who are currently unable to. If you have struggled in the past with getting online or would like to register for Patient Online Services we want hear from you! Throughout September and October Social Action for Health are facilitating a series of workshops that will give you the skills to register to Patient Online Services. By the end of the session you will be registered. In addition we will be supporting GP practice and offering wider support to the community by delivering information stall in venues across the borough. Join our campaign as a patient or a tech champion. We want everyone who lives or works in the borough to support us and together we will bridge the digital divide. Home Events/Activities Blogs Fundraise Tech Champions I don't have access to the internet at home This week we spoke with Daniel, a Hackney resident based in London Field area, to find out more about his experiences of using the the internet and discussing the Patient Online Services. "I don't have the internet at home and I find new things difficult - the project sounds very interesting and I imagine it will help people but I find the internet a scary place and am always worried other people being able to access my personal details" "I have some health problems and when I visit my GP surgery they are helpful but generally I try to avoid making appointments."

domain: health


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Kodansha, the largest Japanese publisher of all and publisher of the runaway success “Attack on Titan”, will be introducing some of their most popular English manga comics at HYPER JAPAN 2014.
Responsible for producing the manga magazines Nakayoshi, Afternoon, Evening, and Weekly Shonen Magazine, this Tokyo based publisher was founded in 1909, and for over a century, has been entertaining readers of all ages, all over the world.
For manga lovers, this will be a chance to find some shiny new reading- and for those unfamiliar with this quintessentially Japanese hobby, it’s a perfect opportunity to learn more about the increasingly internationally famous art of manga. Check out a selection of the titles they’ll be bringing below:
All images on this page © Kodansha Ltd. All rights reserved. No image may be downloaded or reproduced in any form without the prior written permission of Kodansha Ltd.

domain: hobby


text:
Massive Disneyland Attraction Database
Photo: The Magoo's Halt Coaster attraction, which recently celebrated its silver anniversary
Magoo's Halt Coaster
August 6, 1998
Avg. queue length:
This rollercoaster -- the strangest in Toontown -- is made to hold guests of all hair colors.
- If traveling with immature adults , they won't want to queue for this attraction alone.
Guest Policies and Notices
- Expectant parents will probably want to avoid this attraction.
- No talking or monkey business encouraged.
- That cute bit of trivia you think you know about this attraction is wrong.
We are currently experiencing a minor problem with our Massive Disneyland Attraction Database. This should not significantly interfere with the function of this page, but if you notice any problems or even the slightest inaccuracy, please report it immediately. Thank you for your understanding.

domain: travel


text:
become an editor
the entire directory
only in Travel_and_Tourism/Travel_Guides
Travel and Tourism
Regional: Europe: Travel and Tourism: Travel Guides
Lonely Planet - Monaco
- Facts and advice for traveling along with background material on the culture and history of the country.
- Official site of the Government Tourist Office provides information on the Principality of Monaco and Monte-Carlo to leisure travelers and travel agents.
Principality of Monaco
- Webhosting for local companies, mainly real estates. Also a guide to local events, tourist and meeting facilities, history and financial information.
U.S. Department of State - France and Monaco Consular Information Sheet
- Offers travel information including Background Notes, entry and exit requirements, safety and security, crime, health and transport.
World Travel Guide - Monaco
- Tourist and business travel information with facts on climate, visa, health, passport, currency and customs requirements.
" search on:
to edit this category.
Copyright © 1998-2014 AOL Inc.
Visit our sister sites
Last update: January 2, 2007 at 21:47:51 UTC -

domain: geography


March 28, 2022
You’ve probably heard in the news the Postal Service has signed a contract to replace its aging delivery fleet. The Postal Service has said at least 10 percent of its new fleet will be electric, with the exact proportion not yet being decided. So, you may be wondering — what benefits and challenges do electric vehicles bring?
A recent OIG white paper answered that question. We found many benefits — improved sustainability, increased reliability, and let’s not forget lower energy costs. We also found the technology was fairly suitable for postal routes in many parts of the country, although certain factors, such as longer routes and cold weather, could lead to problems.
So, would purchasing electric vehicles save or cost USPS money compared to gasoline-powered ones? The answer to this question is, as with many things, it depends. On certain routes, the lifespan costs of electric vehicles are cheaper and on others it is not. We found USPS would benefit from prioritizing putting electric vehicles on the routes where it would save the most.
We also identified decisions the Postal Service could make to lower the overall cost of electric vehicles, but the decisions often come with trade-offs. For example, the Postal Service could save money by purchasing fewer or less-expensive chargers. This, of course, comes with an increased challenge of keeping vehicles properly charged.
One additional note: On March 14, 2022, we received a congressional request to review the contract’s compliance with the National Environmental Policy Act (NEPA) and other issues not addressed in this paper. We’ll be doing additional work in response to that request.
- Have you bought an electric vehicle? Tell us about your experience.
Source/Comments: USPS Office of Inspector General


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Each summer we retreat to a family cottage in magical Wequetonsing, Michigan. Kids can ride bikes, hit the beach, learn to sail and find out what tennis is all about. It's ok to ride your bike around the block without a parent hovering. Great freedom. Lake Michigan is only about 65 degrees, so adult swimming is scarce, but Zoe and Sophie have been doing cannonballs off the Weque dock and swimming out to the raft with great zest. They are both old enough for the sailing program at day camp. You see them here out with their ten-year-old skipper.
Yesterday was chilly and cloudy until noon. My big kids ventured out on the Third Steet dock to check out the sailing classes. Eliza, my daughter-in-law and in-house professional photographer, was busy shooting away. I hope I get to share some of her shots of the area in my next post.
I never want to go home from this place. Friends come visit, I spend time with friends I've made up here that live all over the country. Lots of books get read, yarn gets spun and the knitting needles click away.


The Warwickshire batsman is the only player in the 14-man party for the three match ODI series who was not involved in England's most recent 4-0 series victory over Pakistan in February.
National selector Geoff Miller said: "We are anticipating a very competitive NatWest series against West Indies and are looking to continue to build on the progress we made in limited overs cricket earlier this year against Pakistan.
"Kevin Pietersen's recent decision to retire from one-day cricket means we now start looking at other options available to us as we prepare to defend our ICC World Twenty20 title and look towards next year's ICC Champions Trophy and the 2015 ICC Cricket World Cup."
It remains to be seen whether Bell, England's most technically correct batsman, be deployed at the top of the order where Pietersen finished his ODI career.
Pietersen's absence also creates an opening in the Twenty20 side as, although he wanted to continue in the shortest form of the game, the England and Wales Cricket Board insisted centrally contracted players must make themselves available for both limited-overs formats or neither.
Nottinghamshire's Alex Hales, whom Pietersen replaced against Pakistan in the United Arab Emirates, is in contention to get the nod after being named in a 13-man Twenty20 squad.
The ODI series gets underway on June 16 at the Ageas Bowl with the one-off Twenty20 international taking place at Trent Bridge on June 24.
England NatWest Series squad:
Alastair Cook (Essex, capt), James Anderson (Lancashire), Jonny Bairstow (Yorkshire), Ian Bell (Warwickshire), Ravi Bopara (Essex), Tim Bresnan (Yorkshire), Stuart Broad (Nottinghamshire), Jade Dernbach (Surrey), Steven Finn (Middlesex), Craig Kieswetter (Somerset), Eoin Morgan (Middlesex), Samit Patel (Nottinghamshire), Graeme Swann (Nottinghamshire), Jonathan Trott (Warwickshire).
England NatWest Int T20 squad:
Stuart Broad (Nottinghamshire, capt), Jonny Bairstow (Yorkshire), Ravi Bopara (Essex), Tim Bresnan (Yorkshire), Danny Briggs (Hampshire), Jos Buttler (Somerset), Jade Dernbach (Surrey), Steven Finn (Middlesex), Alex Hales (Nottinghamshire), Craig Kieswetter (Somerset), Eoin Morgan (Middlesex), Samit Patel (Nottinghamshire), Graeme Swann (Nottinghamshire).


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Disney Princesses Secret Jewelry Case
12 People watching this product now!
- Japan import.
- These small jewelry cases really close with their keys!
- A working mirror on the inside makes this a great little box for your accessories.
- Decorate your jewelry case with a unique sticker sheet that comes with each different princess!
- Designs in this collection:
- Snow White
- Belle (Beauty and the Beast)
- Aurora (Sleeping Beauty)
- Rapunzel (Tangled)
- Ariel (The Little Mermaid)


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Paramount Pictures has announced new casting details for its upcoming remake of 1984's Footloose.
Newcomer Kenny Wormald has won the lead role of Ren, played by Kevin Bacon in the original film.
Dennis Quaid also joins the picture as Reverend Moore. John Lithgow portrayed the first incarnation.
Further, Miles Teller has landed the supporting role of Willard, originally played by the late Chris Penn.
The actors join the previously cast Julianne Hough in the project, directed by Craig Brewer.
The update is scheduled for a 2011 release.

domain: artistic


What we did on our summer vacation: watch lots of Criterion movies, see a few quality blockbusters, and rock out to some sweet summer jams. Oh, and not post very frequently. But fortunately here’s a special end-of-summer podcast to let you know what we’ve been doing this summer pop culture-wise as we head into the cold hard crispness of Fall.
An event is coming! Another event is coming! Summer is here and we all know what that means: Blockbuster movies. 2017 has more franchise and sequel flicks coming out than any other year in history, so we thought we’d celebrate that absolute glut of cinema by actually celebrating the highest achievers in the medium. So, this July, be on the lookout for 30 reviews of 30 films by 29 directors from the Criterion Collection. We’re so excited about the foreign, silent, and black and white films that will be dropping on you that we even had to do a draft so we could each claim the reviews we wanted to do. Check out the podcast, the tentative schedule is after the break.
Well, it’s the first week of the Trump presidency and we could all use a pick-me-up, am I right? Sometimes it might seem hard to look forward to the good times ahead, sometimes you might even forget those good times exist. This week, we’re here to remind you that’s absolutely not the case, there’s plenty to anticipate! Like, 20-or-so movies, for instance. And a 10 movies not to anticipate, but you can eagerly anticipate us discussing them negatively. That’s what people like us are for, the ruthless tearing down of other people’s hard work. Yay!
If 2016 was a script, it would have been rejected for being unrealistic and unrelenting. Lots of people have written something like that, but I don’t have a lot of time to work on this post because it’s already so late. This week we talk about our individual top 10 lists and try to come up with an overall list of our favorite films of the last year. Spoiler alert: we did it, we made that list. Hell yeah!
Makin’ those movie dreams on the small screen?
It seemed impossible, the way things had been.
But along came David Chase and Tony Soprano,
and the world no longer loved Ray Barone a.k.a. Romano.
Now the world’s a confusing and complicated place,
there’s so much good stuff it’s hard to keep pace.
Don’t believe me? Check out this podcast.
It’s hard to believe how little was broadcast.
If you’re being honest, do all the non-Oscars movie awards shows matter to you? Do you care about the various guilds’ picks? What about lists from critics, newspapers, and blogs? Certainly you don’t care about the Golden Globes, right? Not really, at least, because all those people are going to be talking about the same 10 or so movies which are undeniably great. And that’s true, to a lesser extent, in pretty much every medium.
That is why, for five years now, the Mildly Pleased Awards have celebrated the “good, not great” works that would otherwise go forgotten. After all, everyone one of us just lived through a whole 365 days of 2016. If we were to just talk about the 10 good days, it wouldn’t really do the year justice, would it? So join us as we count down the most OK video games, music, TV, and film from the last year. Oh, and hit the jump to check out our viral video nominees… They’re fine!
The original idea for Top Ten Thursdays was a simple solution to two problems: one, writing T3 posts on the blog was a contentious, time-consuming affair and two, Da Podcasket was a meandering, directionless mess. So doing a podcast where we made lists seemed to be the perfect solution – it would be easier to jot down nominees and talk about them as a group than to try to do the whole thing solo written, and our podcast would have an actual hook to get people interested. But as our professional lives became more busy and we invented other types of shows that better complimented our strengths, Top Ten Thursdays became something of a black sheep – or perhaps even an albatross keeping us from podcasting.
So we decided it was time to retire the old girl. But we couldn’t do that without a proper send-off, which is what you have here as episode 100 (give or take a few). Join us as we reminisce over some of our favorite moments while trying to track the history of the show over its four and a half year run. You know we did this one right: little to no research, one long take, plenty of jokes we’ll regret later. It’s the end of T3, Judgement Day is finally here! The machines will rise!


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Singer-Songwriter Edwin McCain: "I'll Be" and "I Could Not Ask for More"
* Additional fees apply. No coupon or promo codes necessary to enjoy the displayed discount price.
The last date listed for Edwin McCain was Sunday August 17, 2014 / 7:00pm.
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With some of the most singable songs in classic rock, the Steve Miller Band has remained a radio… More


Driving east on the Dewdney Trunk Road, you always knew you were passing through Webster’s Corners when you saw the Sampo Hall on the right and the old co-op buildings on the left.
These buildings have been part of the local landscape for so long that we’ve almost stopped seeing them as individual buildings. More than that, they form a part of our communal perception of the neighbourhood called Webster’s Corners.
But no more – last week, with no fanfare, one of the old co-op buildings came down.
Loss of familiar landmarks and historic buildings is a problem that plagues all communities. Our landmarks map our familiar world and populate our memories of place. They don’t need to be grand or flashy – they just need to be there.
A lot of buildings that were once, if not community-owned, at least communally owned are now in private hands. That is true of both the old co-ops and the Sampo Hall.
Our municipality has some good programs to offer owners who want to participate and retain their older structures. We have seen several recent agreements involving private homes that will see those homes retained as community heritage assets for the foreseeable future.
However, there is no way to force or coerce an owner to have that level of enthusiasm.
Another way for the community to acquire beloved assets is to buy them. That is the only real form of protection, but it comes at a high cost. As an owner, the municipality has to meet high standards before a building can be rented or leased for use.
How does the municipality know when buying a property is the best option? We have to tell them.
At the moment, the municipality is engaged in the creation of a Heritage Strategic Plan. The plan is meant to identify the wants and needs of the citizens of Maple Ridge for all their different neighbourhoods, then to prioritize them, given scarce resources. This is your opportunity to make your feelings known to the municipality and your fellow citizens.
Working at the museum, I often hear the complaint from people that all heritage preservation happens in Haney. Where are the preservation efforts for neighbourhoods like Webster’s Corners, Whonnock or Port Hammond? What is left to preserve there? What can we do to put back what has already been removed?
The more voices the better in matters like these. It is too easy for heritage concerns to be slid off the plate in the name of other projects.
You can make your feelings known by responding to an online survey. Or stop by the museum and pick up a paper copy.
If community history is important to you, get engaged in the process before all we’re left with is fading memories.
Val Patenaude is director of Maple Ridge Museum and Community Archives.


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What excites you about the future of design in Canada?
Canadian designers are being celebrated the world over for their ingenuity, creativity and moxie. I think this will only continue.
What’s becoming increasingly clearer though is that the big opportunity for design, is not just to create beautiful things, but to make transformational change. And with the ever increasing tech and innovation sector in Canada, the potential future opportunities for designers will eventually be endless.
What advice would you give to youth looking to get involved in the arts and culture community?
Persistence, gumption and moxie.
Everything is getting increasingly more competitive but always remember that ‘no’ is the first letter of the word ‘yes’. Never be afraid to ask, call, or walk up to someone at an event or party and introduce yourself. The worst thing that anyone can ever do is say ‘no’ — and technically, that’s not really such a bad thing afterall.
What’s a highlight from your experience at The Breakout Project?
The audience’s reaction.
During my presentation, I played a video about Zipline, a US/Rwandan company that has figured out how to deliver blood to remote Rwandan communities by drone. So if a surgeon is in mid-surgery and runs out of blood, it would be received in a few minutes rather than a few days – this is the difference between life and death for so many patients.
When the video ended, the audience clapped and cheered. It was clear that they too were positively impacted and excited by the potential of design, innovation and technology.
If you could kickstart your own word-changing project what it be?
I hope to be able to announce it next year (stay tuned)!


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Obverse legend : PIVS. IX. PON. - MAX. AN. IX..
Obverse description : Buste du Saint-Père, Pie IX à gauche ; au-dessous, signature B. Z..
Obverse translation : (Pie IX souverain pontife, neuvième année).
Reverse description : Dans une couronne, en trois lignes : 1/ SCVDO/ 1862 et à l’exergue R.
VATICAN - PIE IX (Jean-Marie Mastai Ferretti)
Pius IX (1792-1878), elected after a vacancy of only fifteen days, with the longest pontificate nineteenth century. After a happy beginning, showing him, or at least a liberal innovative between 1846-1848, the Roman revolution rejects conservatism. After the February Revolution in France, agitation wins all over Europe and even Rome. Given the refusal of Pius IX declared war on Austria, the Republic was proclaimed on February 9 at the instigation of Mazzini and Garibaldi. On June 1, an expeditionary force was sent to Rome to restore order. The French took the city on July 3 and restore Pius IX. It can not prevent Victor Emmanuel II to achieve Italian unity and finds himself isolated from 1861. Rome resists another nine years before falling into the hands of the king of Italy and became the capital in 1870. Pius IX saw the last nine years of his life in considering himself as a prisoner of the Italian power.

domain: library


Specification for employer substitute forms P60
This guide gives information on how to design substitute forms P60, ‘End of Year Certificate’ which employers may use instead of the official form, at the end of the tax year.
It also includes information on how to adapt your substitute form P60 for a pension fund scheme and what to do if you intend to issue the substitute form P60 to your employees electronically. This revised edition applies for the tax year 2018 to 2019.
Forms P60 cover:
• PAYE Income Tax
• National Insurance contributions
• Statutory Maternity Pay
• Statutory Paternity Pay
• Statutory Shared Parental Pay
• Statutory Adoption Pay
• Student Loan deductions
You need to obtain HMRC approval before a substitute form P60 is brought into use. This applies to a:
• New substitute
• Previously approved substitute, irrespective of whether any changes have to be made or not.
Substitute forms P60 must be submitted annually to this office for approval. Email a draft of the proposed substitute P60 design for 2018 to 2019 (for example, PDF) to email@example.com.
The HMRC office gets very busy in the last 4 months of the tax year so our turnaround time from November 2018 to April 2019 will be 4 weeks.
To meet your deadlines we recommend that you submit proposed drafts as soon as possible and before 1 March 2019.


One Fox News contributor seems to suggest President Donald Trump should use the recent death of a California police officer as a sort of bargaining chip for his border wall.
Appearing Friday on Outnumbered Overtime, Rachel Campos-Duffy said Trump should politicize the death of police officer Ronil Singh in Newman, California to secure the funding for his border wall, Mediaite reports.
Singh’s murder on Wednesday has created plenty of media controversy and the suspect, Gustavo Perez Arriaga, was arrested Friday morning at a home in Bakersfield, California, The Modesto Bee reports. Adrien Virgen, the suspect’s 25-year-old brother, and co-worker Erik Razo Quiroz, 35 were also arrested on alleged accessory charges.
Arriaga reportedly illegally crossed the border into Arizona several years ago. And according to Stanislaus County Sheriff Adam Christiansen, Arriaga was on his way back to Mexico.
So of course, Campos-Duffy is banging the drum for Trump to use fear-mongering tactics by capitalizing on Singh’s death to sledgehammer Democratic opposition to the wall:
“His bargaining power would increase if he gets out the message more,” she said. “Twitter has been great, but it’s not enough. We had a police officer die at the hands of an illegal immigrant just yesterday. It was absolutely tragic, but this is more than just the crimes that comes over the border, we have drugs that are coming over the border that are devastating communities…I think he needs to make the case to the American people.”
Campos-Duffy contended that even though the shutdown impacts the whole country, Trump will win the political battle if he pushes a strong message and gains the trust of the people. She seems to be echoing what Corey Lewandowski, who appeared earlier on Fox News said when he said Democrats should be held accountable for Singh’s death.
But the social science research on this is quite clear, The Washington Post reports. Undocumented immigrants are much less likely than native-born citizens. Scores of studies have been published in the last several months that clearly illustrate this. One study in particular, by the Libertarian Cato Institute, examined 2015 criminal conviction data provided by the Texas Department of Public Safety. And it found that native-born citizens were far likelier to commit crimes than immigrants whether they were legal or illegal.
Further, the institute notes there were 785 homicide convictions in Texas, and out of that number 709 native-born American citizens were convicted. Illegal immigrants were convicted of 46 homicides and legal immigrants were convicted of 30 homicides.
The Cato Institute included numerous other charts which showed just how low crime rates are for illegal and undocumented immigrants. These figures belie fears promulgated by Trump and media figures like Campos-Duffy. Anti-immigrant rhetoric is harmful, and as these charts show, just plain wrong.
And that’s unfortunate because it harms people who are trying to escape situations most of us can barely imagine.
Watch Campos-Duffy in the video below and see what you think.
Screenshot by Fox News Insider via YouTube video


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Tomorrow we will reveal Australia’s top 10 Favourite Novelists!
Today the countdown continues, 20-11 as voted by you.
Take a look back at the past couple of days to see if your favourite author made the cut.
Australian-born Geraldine Brooks is an author and journalist who grew up in the western suburbs of Sydney, and attended Bethlehem College Ashfield and the University of Sydney. She worked as a reporter for The Sydney Morning Herald for three years as a feature writer with a special interest in environmental issues.
In 1982 she won the Greg Shackleton Australian News Correspondents scholarship to the journalism master’s program at Columbia University in New York City. Later she worked for The Wall Street Journal, where she covered crises in the the Middle East, Africa, and the Balkans.
She was awarded the Pulitzer Prize in fiction in 2006 for her novel March. Her first novel, Year of Wonders, is an international bestseller, and People of the Book is a New York Times bestseller translated into 20 languages. She is also the author of the nonfiction works Nine Parts of Desire and Foreign Correspondence.
19. Rachael Johns
An English teacher by trade, a supermarket owner by day, a mum 24/7, and a writer by night. That’s some of the ingredients that make up one of the most successful Romance Writers in Australia, Rachael Johns.
In a relatively short space of time, Rachael has shown herself a force to be reckoned with, helping to bolster a new movement in Australian Romance writing. At 17 she began writing, enlightened by the thought that she could create whatever ending she liked, and almost a decade later, after many, many attempts at writing different types of novels, she joined the Romance Writers of Australia association.
It was there that Rachael learnt there was more to writing a book than just typing out random thoughts. She learnt about the craft, conflict, consistent characters, etc, and also discovered that she loved contemporary romance.
She lives in rural Western Australia with her husband and their three children.
Congratulations Rachael on coming 10th in the vote for Australia’s Favourite Novelist for 2013.
18. Ruth Park
Another in a long line of writers born elsewhere yet able to capture Australian life so beautifully, Ruth Park’s writing has had a lasting effect on both adults and children for over 60 years.
Born in Auckland to a Scottish father and a Swedish mother, Park moved to Australia in 1942 where she had lined up a job with a newspaper.
Her first novel was The Harp in the South, a graphic story of Irish slum life in Sydney, which has been translated into 37 languages. Even though it was acclaimed by literary critics, the book proved controversial with sections of the public due to its candour. It remains her most popular novel and has never been out of print.
Between 1946 and 2004, she received numerous awards for her contributions to literature in both Australia and internationally including the Miles Franklin Award for Swords and Crowns and Rings in 1977. She was made a Member of the Order of Australia in 1987.
Andy Griffiths is one of Australia’s most popular children’s writers. He is the author of over 20 books, including nonsense verse, short stories, comic novels and plays. Over the past 15 years Andy’s books have been New York Times bestsellers, won over 50 children’s choice awards, been adapted as a television cartoon series and sold over 5 million copies worldwide.
Andy has had a long-standing collaboration with illustrator Terry Denton. Their latest collaboration is The 13-Storey Treehouse which was voted ABIA’s 2012 Book of the Year for Older Readers, and September 2012 sees the hugely anticipated The 26-Storey Treehouse. Meanwhile Andy and Terry are also working on a collection of inspirational writing exercises called Once Upon a Slime for English teachers and emerging writers and illustrators to be published in April 2013.
Kate Forsyth is the bestselling and award-winning author of more than twenty books, ranging from picture books to poetry to novels for both children and adults.
Since The Witches of Eileanan was named a Best First Novel of 1998 by Locus Magazine, Kate has won or been nominated for numerous awards, including a CYBIL Award in the US. She’s also the only author to win five Aurealis awards in a single year, for her Chain of Charms series – beginning with The Gypsy Crown – which tells of the adventures of two Romany children in the time of the English Civil War. Book 5 of the series, The Lightning Bolt, was also a CBCA Notable Book.
Kate’s books have been published in 14 countries around the world, including the UK, the US, Russia, Germany, Japan, Turkey, Spain, Italy, Poland and Slovenia. She lives by the sea in Sydney, Australia, with her husband, three children, a rambunctious Rhodesian Ridgeback, a bad-tempered black cat, and many thousands of books.
Christos Tsiolkas was born in Melbourne in 1965. Loaded, his first novel, was published in 1995 and later made into the award-winning film Head On. In 1996 he collaborated with Sasha Soldatow on the dialogue Jump Cuts. His novel The Jesus Man was published in 1999.
He is the author of several plays including Who’s Afraid of the Working Class?, Dead Caucasians and Non Parlo di Salo, co-written with Spiro Economopoulos.
His critically acclaimed novel Dead Europe was published in 2005 and in 2008 he reached bestselling status with the bold The Slap which won the Commonwealth Writers Prize and was shortlisted for the Miles Franklin Award.
Isobelle Carmody is Australia’s most highly acclaimed author of fantasy titles for older readers.
She began her first book, Obernewtyn, when she was fourteen and since then she has written some of our greatest works of fantasy. She is perhaps best known for her Obernewtyn Chronicles and for her novel The Gathering (joint winner of the 1993 Children’s Literature Peace Prize and the 1994 CBC Book of the Year Award).
Another of her novels, Greylands, was joint winner of the 1997 Aurealis Award for Excellence in Speculative Fiction – Young Adult Division, and was named a White Raven at the 1998 Bologna Children’s Book Fair. She has also written many short stories for both children and adults.
Isobelle divides her time between Prague in the Czech Republic and her home on the Great Ocean Road in Australia.
Fiona McIntosh is a fantasy author originally born in Brighton, England. At the age of nineteen, she travelled first to Paris and later to Australia, where she has lived ever since.
She worked for many years in the travel industry but after her shift to full-time writing she roams the world researching and drawing inspiration for her novels.
Adelaide is her home base, which she shares with her husband and twin sons, but Fiona does most of her writing from the peace of southern Tasmania.
To date she has written 24 adult novels across various genres and seven novels for children.
Rachael Treasure currently lives in southern rural Tasmania with her two young children, Rosie and Charlie. Her three novels, Jillaroo, The Stockmen, and The Rouseabout, have all been bestsellers in Australia, selling more than 100,000 combined copies by the end of 2007. In 2008 Random House signed her to a 4 book contract for British release.
A former jillaroo and reporter for the Australian Broadcasting Corporation on rural affairs, she is a passionate working dog trainer and in 2007 received Tasmania’s rural woman of the year award.
11. John Flanagan
John Flanagan’s bestselling Ranger’s Apprentice adventure series originally comprised twenty short stories, which John wrote to encourage his twelve-year-old son, Michael, to enjoy reading. The series has come a long way since then.
Now sold to more than twenty countries, the series regularly appears on the New York Times Bestseller List and has been shortlisted in children’s book awards in Australia and overseas. John, a former television and advertising writer, lives with his wife, Leonie, in the Sydney beachside suburb of Manly. He is currently writing further titles in the Ranger’s Apprentice series.
We will announce the Top 10 on Monday.
This article first appeared on Booktopia.


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Energy Estate, Media Release, 22 September 2023
The Moah Creek Wind Farm project (the Project) has recently reached two development milestones.
Firstly, it has been granted planning approval from the Queensland State Assessment and Referral Agency (SARA). This approval is a significant stage in the development process for the Project as it provides consent from the Queensland Government under the Planning Act 2016 for the construction of the wind farm and its associated vegetation clearing. The development application was assessed against State Code 23 (Wind Farm Development) and Code 16 (Clearing Native Vegetation).
SARA’s approval notice and the associated conditions can be found on the SARA planning portal under the reference 2211-32177 SDA.
The Project has been designed to minimise native vegetation clearing to the greatest extent possible, with the clearing of ‘of concern’ and ‘endangered’ native vegetation (as defined by the Native Vegetation Act (1999, Qld) reduced to less than 1 per cent of the Project’s total footprint. This has been achieved through 2.5 years of substantive field surveys and an iterative design process.
The second milestone is that the Project has now been referred to the Department of Climate Change, Energy, the Environment and Water (DCCEEW) for review under the Commonwealth Environment Protection and Biodiversity Conservation Act 1999 (EPBC Act). Following DCCEEW’s assessment, a public comment period will be announced and notice of this will be widely communicated, including via the Project’s website. The public comment period allows those who have concerns as to its impact on the environment, have their say.
The Project is expected to start construction in Q2 2025 and will deliver a range of social and economic benefits to Rockhampton and the region to include providing clean electricity sufficient to power the equivalent of over 195,000 houses, an estimated investment of approximately $1 billion, the creation of approximately 400 jobs at the peak of construction, a community fund and a Neighbour Shared Benefit scheme.
Vincent Dwyer, Director of CQP stated "These development milestones for the Moah Creek Wind Farm are timely given the Palaszczuk government’s recent announcement that the state-owned energy company Stanwell Corporation will be starting early works this year on its Future Energy and Innovation Training Hub (FEITH), based in Rockhampton." The hub will be a facility to test new renewables technologies. including wind, as well as a practical training facility to develop the skills needed to help deliver on Queensland’s Energy and Jobs Plan.
The Project is located 30 km west of Rockhampton and 10 km north-west of Stanwell, in the Rockhampton Regional Council Local Government Area and includes the development of a wind generation facility (including up to 60 turbines) and associated infrastructure. It will connect into the existing 275-kilovolt (kV) transmission line that traverses the project site. Once operational, the Wind Farm is expected to deliver up to 372 megawatts (MW) of renewable energy capacity into the National Electricity Market. Moah Creek Wind Farm is being developed by Central Queensland Power (CQP), a joint venture between RES Australia and Energy Estate. CQP is a portfolio of wind, solar, and storage projects with new transmission infrastructure with a capacity of over 4GW in the Fitzroy Renewable Energy Zone. Currently CQP includes six large strategically located wind, solar and battery storage projects.
Related stories: Energy Estate responds on Moah Creek Wind Farm, The Nationals shine light on renewables impact: Littleproud, Boyce, Landry


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First publishedon www.ITSInternational.com
ST Engineering has added BYD as its first partner in a consortium which seeks to deploy driverless buses in Singapore.
The company is equipping BYD’s electric buses with autonomous vehicle technology. The vehicles will operate in the towns of Punggol, Tengah and the Juroung Innovation District located in Singapore’s western corridor.
The consortium is being formed following a request from Singapore’s Land Transport Authority and the Singapore Economic Development Board to trial autonomous buses and shuttles.
Dr Lee Shiang Long, president of land systems at ST, says: “We continue to explore partnerships with like-minded companies and incorporate their capabilities into a proposal that offers a sustainable and scalable transportation solution for Singapore.”
Autonomous technology is already being phased into Singapore. Earlier this month, Volvo announced plans to trial a 12m long autonomous electric bus on roads at the Nanyang Technological University (NTU) ahead of an anticipated release onto public roads.

domain: news


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DACH1 is a novel predictive and prognostic biomarker in hepatocellular carcinoma as a negative regulator of Wnt/β-catenin signaling
Metrics: PDF 3240 views | HTML 3336 views | ?
Yu Liu1, Rong Zhou1, Xun Yuan2, Na Han2, Si Zhou1, Hanxiao Xu2, Mingzhou Guo3, Shiying Yu2, Cuntai Zhang1, Tiejun Yin1, Kongming Wu2
1Department of Geriatrics, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China
2Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China
3Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing, P.R. China
Tiejun Yin, e-mail: [email protected]
Kongming Wu, e-mail: [email protected]
Keywords: DACH1, hepatocellular carcinoma, Wnt/β-catenin signaling, prognostic factor, TMA
Received: December 09, 2014 Accepted: February 05, 2015 Published: April 02, 2015
The cell fate determination factor Dachshund (DACH1) functions as a novel suppressor in the progression of various neoplasms. Previous study has suggested that hypermethylation of promoter region was responsible for the reduction of DACH1 expression in hepatocellular carcinoma (HCC), and associated with the progression of HCC, but the clinical significance and the exact molecular mechanisms of DACH1 in the progression of HCC remain unclear. In this study, we employed public microarray data analysis and tissue microarrays (TMAs) technologies and showed that DACH1 expression was reduced in HCC even at early stage and associated with the tumor progression. Notably, Kaplan-Meier analysis further indicated DACH1 could be an independent prognostic factor for the overall survival of HCC. Further, mechanistic studies revealed that overexpression of DACH1 inhibited the growth and migration of HCC cell line, which were dependent in part on the inactivation of Wnt pathway via phosphorylation of GSK3β to suppress β-catenin. In agreement, the abundance of DACH1 was inversely correlated with several Wnt target genes. Collectively, our study indicated β-catenin is a novel target of DACH1 in HCC.
All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.

domain: medical


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I have a serious unease about the arrest of Jamie Bryson and Willie Frazer. (I know nothing of the third arrest) I think it is a misguided and ill-timed political decision that may have serious implications for the peace.
This is yet another game by Sinn Fein, who are using the Chief Constable as a foil, and who are probably hoping that the protests will turn violent again. I hope that the protestors do not play Sinn Fein’s game.
The Unionist Forum, that I recently attended, was populated by speakers who wanted a level playing field for loyalists and I suspect that these arrests will give argument to those who are already suspecting that they are being treated in a lesser manner.
Where are the level headed politicians to advise the Chief Constable? Are they cowering under their bed afraid to make a sound in the hope that the protestors will go away?
I also feel unease about the fact that Willie Frazer was refused bail and sits in prison and was refused bail whilst a man accused of the double murder of two British soldiers walks out on bail.
I need to make this clear. I condemn all violence but I do not condemn protests. I would call on protestors to respect and obey the law and not to disrupt the life of Northern Ireland people. To protest is the way of a democracy and democracy can only stand with-in the rule of law.
Democracy does not exist in countries where protests are forbidden.
That is part of what concerns me here. The Parades Commission and the parades laws were made to bring a state of stability to the Northern Ireland marching season….. Now, The Chief Constable and the head of the Parades Commission is calling on them to be toughen to stop protests.
We allow that at our peril. This is where our level headed politicians should step in…… if they can be found.
If the law of the land is broken then that must be addressed but the Chief Constable knows that this is a political gamble. I just hope that this seriously flawed and ill timed decision does not cost lives.
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domain: sociology


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GOP in tumult after McCarthy's withdrawal from speaker race
WASHINGTON (AP) — Jolted by political lighting for the second time in two weeks, House Republicans are staring at turmoil and uncertainty after Majority Leader Kevin McCarthy's astonishing decision to abandon his campaign to become the chamber's next speaker.
Obama focusing on condolences, not gun laws, in Oregon visit
WASHINGTON (AP) — President Barack Obama is bringing words of comfort and sympathy to grieving families of victims of the shooting rampage in Roseburg, Oregon, muting his message about the need for new laws to stem gun violence as he visits an area where firearms are popular.
US airman stabbed months after thwarting French train attack
SACRAMENTO, Calif. (AP) — Airman 1st Class Spencer Stone, hailed as a hero after he was severely cut while helping stop a terror attack on a French train in August, was repeatedly stabbed in what police said was an alcohol-fueled, late-night brawl in a Sacramento nightclub district.


November 12, 2013
Lauren Skiver will be continuing an effort begun by Interim GM Roger Snoble asking staff to re-evaluate all aspects of the operations.
November 7, 2013
Within three years, the agency is expected to use approximately 700,000 diesel gallon equivalents of CNG per year, which reduces greenhouse gases by 1,622 metric tons per year, the equivalent of taking 335 cars off the road per year.
October 15, 2013
It is estimated that global penetration of hybrid buses will reach 9.7% by 2020, while electric buses will attain 5.7% penetration. Together, hybrid and electric transit bus unit shipments will reach close to 42,000 units.
September 26, 2013
Buses fueled by natural gas would be the lowest-cost option for CityBus in a 15-year project that examined expenses of buying buses, maintaining them and keeping them fueled. The diesel-electric hybrid would be the costliest.
September 11, 2013
Flint MTA, Greater Cleveland RTA, Metro Cars, Port Columbus International Airport and Unified Government of Wyandotte County, Kan., each received a “Top User of Clean-Burning Propane Autogas” award.
September 10, 2013
The morning was packed with educational sessions covering topics such as Alternative Fuels, Electric Buses, Updates on ADA and DOT regulations, and safety. More buses than ever in all shapes and types are on display including several electric bus models.
August 29, 2013
The data from a Pike Research report, Electric Drive Buses, says that by 2018 annual sales of buses with hybrid systems, battery electric systems or fuel cells will reach 20,000 worldwide, compared to 5,000 expected in 2012.
August 6, 2013
Plans to acquire up to 300 CNG buses as part of its bus replacement plan in the coming years, along with the infrastructure required to fuel and maintain them.
July 29, 2013
Sees an estimated savings of $5,000 to $6,000 a year in maintenance costs alone on the 15 bi-fuel shuttles, and has reduced its fuel spent by 50% compared with gasoline.
July 1, 2013
The new propane-powered Ford transit vehicles will save taxpayer dollars and help improve community air quality.
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The Chief at the University of Illinois
February 19, 2007 4:17pm CST
As a student at this University, I am kind of confused about recent events. I understand that it has been a downward spiral, and we have had pressure from the NCAA to get rid of our Chief, and also from Native American groups. I still do not understand why this angers the Native Americans. The students get excited and honor the chief, we don't see him as a mascot. We see the chief as a symbol of honor. I am a small portion of native american, and although some may feel that it isn't enough, I am proud to be represented by a symbol that is so revered by the students. I just can not understand why it is not ok for us to respect the chief, while Notre Dame can keep their fightin' irish in the same respect.
1 person likes this
• United States
20 Feb 07
I have read and seen a lot about what you are speaking of. I don't quite understand it myself. How far are the head honchos going to take political correctness? Mocking Native Americans and paying respect to them are vastly different. What the Native Americans used to be and what they are now are different, but no less important. The Native American people were given a hard, and deadly time. And I see your point about the Notre Dame Irish. They were discriminated against sooo much when they emigrated to America. I don't know where to draw the line, but I know it shouldn't be drawn yet.


New Delhi: To promote its flagship Make In India programme, the Narendra Modi government has cleared its own version of the US’s Buy American policy through a national government procurement policy, giving preference to locally made goods and services.
Titled “Government procurement preference to Make In India order, 2017”, the new policy, cleared by the Union cabinet on Wednesday, is expected to give a substantial boost to local manufacturing and services sectors, thereby creating jobs. “It will also stimulate the flow of capital and technology into domestic manufacturing and services… (and) provide a further thrust towards manufacture of parts, components, sub-components etc. of these items, in line with the vision of ‘Make in India’,” a cabinet statement said.
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PDT Partners LLC bought a new position in Calithera Biosciences, Inc. (NASDAQ:CALA) in the 2nd quarter, according to the company in its most recent filing with the Securities and Exchange Commission. The firm bought 18,690 shares of the biotechnology company’s stock, valued at approximately $278,000. PDT Partners LLC owned approximately 0.05% of Calithera Biosciences at the end of the most recent quarter.
Other institutional investors and hedge funds have also recently modified their holdings of the company. Legal & General Group Plc acquired a new position in shares of Calithera Biosciences in the 2nd quarter worth approximately $120,000. Raymond James Financial Services Advisors Inc. acquired a new position in Calithera Biosciences during the 1st quarter valued at approximately $117,000. Hillsdale Investment Management Inc. acquired a new position in Calithera Biosciences during the 2nd quarter valued at approximately $166,000. Nationwide Fund Advisors acquired a new position in Calithera Biosciences during the 1st quarter valued at approximately $131,000. Finally, KCG Holdings Inc. acquired a new position in Calithera Biosciences during the 1st quarter valued at approximately $144,000. Institutional investors own 71.88% of the company’s stock.
Calithera Biosciences, Inc. (NASDAQ:CALA) opened at 17.75 on Wednesday. Calithera Biosciences, Inc. has a 52 week low of $2.20 and a 52 week high of $20.05. The firm has a 50-day moving average price of $16.15 and a 200-day moving average price of $14.69. The stock’s market cap is $629.70 million.
Calithera Biosciences (NASDAQ:CALA) last announced its quarterly earnings results on Tuesday, August 8th. The biotechnology company reported ($0.15) EPS for the quarter, beating the Zacks’ consensus estimate of ($0.29) by $0.14. The business had revenue of $7.26 million for the quarter, compared to analysts’ expectations of $4.80 million. On average, equities research analysts predict that Calithera Biosciences, Inc. will post ($0.81) EPS for the current year.
In other Calithera Biosciences news, major shareholder Adage Capital Partners Gp, L.L sold 576,000 shares of the stock in a transaction that occurred on Thursday, September 28th. The shares were sold at an average price of $15.64, for a total value of $9,008,640.00. The transaction was disclosed in a legal filing with the SEC, which is available through this link. Corporate insiders own 16.30% of the company’s stock.
A number of research analysts recently issued reports on CALA shares. Zacks Investment Research upgraded Calithera Biosciences from a “hold” rating to a “strong-buy” rating and set a $21.00 price objective for the company in a research report on Tuesday, July 11th. William Blair assumed coverage on Calithera Biosciences in a research note on Thursday, October 5th. They set an “outperform” rating on the stock. Finally, BidaskClub downgraded Calithera Biosciences from a “sell” rating to a “strong sell” rating in a research note on Saturday, August 12th. One analyst has rated the stock with a sell rating, two have issued a hold rating and five have given a buy rating to the stock. Calithera Biosciences currently has a consensus rating of “Buy” and an average target price of $15.50.
About Calithera Biosciences
Calithera Biosciences, Inc is a clinical-stage pharmaceutical company. The Company focuses on discovering and developing small molecule drugs directed against tumor and immune cell targets that control key metabolic pathways in the tumor microenvironment. It is engaged in developing agents that take advantage of the metabolic requirements of tumor cells and cancer-fighting immune cells, such as cytotoxic T-cells.
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This week has gone fairly well. We've seemed to have pulled out of the early sping cold weather and gotten at least to a relatively comfortable zone. I am still amazed at her ability to handle the cold and the rain storms so well.
She growing every week at a decent rate.
Ive kept her nutrient schedule relatively low and feed her approximately once, maybe twice per week. Otherwise its just plain water from the hose. I try letting the water sit for 24 hours on the hope that the sun will evaporate out some of the negative elements in the water, excess chlorine etc.
She responded well to the pinching of her top, although it should have been done sooner, but the site appears healed and healthy. I may plan to top her a few more times over the coming weeks.
I found my first obvious sign of bug activity, in the spider web on her top most leaves, im hopeful its a predatory spider and not mites. Seeing that webs seem to get me in the face when i pass her I'm betting on a regular spider.
Happy growing and harvesting to everyone, thank you for all the support.


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text:
Welcome to New Dimensions Radio!
What would you do if you were invited to listen to one of the best storytellers in the world today? Come listen then, to the magical voice of Gioia Timpanelli, often called the "dean of American storytelling": "Human beings are just storytelling creatures. We tell stories no matter what. We need them the way we need food and drink. We tell our lives in stories." With the hunger for stories comes the necessity to listen, slowing down enough to let the words sink beneath your skin. Through the spoken word, we can see ourselves reflected in the mirror of the tale. When a story is heard in this way, it is remembered for a lifetime, the many layers of meaning surfacing as we mature. (hosted by Michael Toms)
Gioia Timpanelli, who has won two Emmy Awards for her work in storytelling on educational television, is a recipient of the Women's National Book Association Award.
She is the author of:
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domain: literature


What Is Creativity?
Testing for creativity, and its corresponding physical attributes in the brain, requires defining the term, but creativity is not so easily broken down.
Testing for creativity, and its corresponding physical attributes in the brain, requires defining the term, but creativity is not so easily broken down. "'Creativity is kind of like pornography — you know it when you see it,' said Rex Jung, a research scientist at the Mind Research Network in Albuquerque...Like many researchers over the past 30 years or so, Dr. Jung has relied on a common definition of creativity: the ability to combine novelty and usefulness in a particular social context. As the study of creativity has expanded to include brain neurology, however, some scientists question whether this standard definition and the tests for it still make sense."
- Patients from low-income neighborhoods are most at risk of negative health impacts.
- But increased longevity is a cause for celebration, says Ashton Applewhite, not doom and gloom.
Some evidence attributes a certain neurological phenomenon to a near death experience.
- The research raises many ethical questions and puts to the test our current understanding of death.
What's dead may never die, it seems
The researchers did not hail from House Greyjoy — "What is dead may never die" — but came largely from the Yale School of Medicine. They connected 32 pig brains to a system called BrainEx. BrainEx is an artificial perfusion system — that is, a system that takes over the functions normally regulated by the organ. Think a dialysis machine for the mind. The pigs had been killed four hours earlier at a U.S. Department of Agriculture slaughterhouse; their brains completely removed from the skulls.
An ethical gray matter
The dilemma is unprecedented.
Setting new boundaries
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Landlords in England get ready for right to rent
The new law means that from February 1, 2016, landlords will have to carry out quick and simple checks to ensure potential tenants have the right to rent property in the UK.
From this week commencing 4 January, landlords can start to carry out right to rent checks as these can be done from 28 days before the start of a tenancy agreement.
Right to rent was first introduced in parts of the West Midlands in December 2014 and the extension to England is the next phase of a UK Wide roll out.
Landlords, and anyone who sublets or takes in lodgers, could face a financial penalty of up to £3,000 per tenant if they are found to be letting property to someone who has no right to stay in the UK.
The government has been working with an expert consultative panel, which includes trade bodies, local authorities and charities, to listen to feedback from the first phase of the scheme.
The panel has advised on an updated landlords code of practice which includes changes to the acceptable document list to make it even simpler to conduct a check. ■


If i'm not mistaken, VT support is not needed to run ESXi and definitely isn't needed on ESX - which if I may add, ran fine on this CPU/machine model.
Success so far!
Booting off the CD is impossible, since it freezes but don't ask me why THIS works:
PXE booting works just fine!
So how come this doesn't work? Who the hell knows. So I have tftp-hpa running on a Gentoo machine here on our network to provide the cd's contents to the boot menu. Adding this to my pxelinux.cfg/default:
LABEL ESX 3i Install
append esxi/vmkernel.gz --- esxi/binmod.tgz --- esxi/ienviron.tgz --- esxi/cim.tgz --- esxi/oem.tgz --- esxi/license.tgz --- esxi/install.tgz
I copied the root of the cd off into the esxi folder under the tftp root directory. There's plenty of instructions on how to set this up as well out there, but I can help with some questions if you have them. Let me know how this works for ya'll.
I am currently running with the precision 490 on esx 3.5i as well as 3.5 for testing purpose. I will say the config different I had with you is, I am using the Xeon processor which is same with the server processor on PE 2950. For memory I am using 16GB ECC servers memory. I am running my environment without raid and only SATA DISK. Everything is working accordingly.
Malaysia VMware Communities - http://www.malaysiavm.com
I'll admit I haven't read all of the posts on this thread, so if I'm revisiting old topics, I apologize.
I'm assuming changing the SATA options in the BIOS of the T3400 to RAID Autodetect/ATA is somehow adversely affecting the operation of the SATA optical drive. Hence the lockups when using that mode.
I have come up with a different answer that is easier than setting up a PXE environment. All you need is a blank USB Key (Thumb, Pen, Jump, etc.) Drive and about 10 minutes. Here goes:
Download UNetbootin. I used the Windows version available here: http://sourceforge.net/project/downloading.php?groupname=unetbootin&filename=unetbootin-windows-281.exe&use_mirror=internap
Run UNetbootin, select Distribution, FreeBSD, Version 7.0. At the bottom select USB Drive as the Type and the appropriate drive letter for your blank drive as the Drive. Click OK.
Once UNetbootin completes, copy the contents of the ESXi CD to the USB Drive.
On the USB drive, rename syslinux.cfg to syslinux.cfg.OLD.
Make a copy of the ISOLINUX.CFG file and rename it to syslinux.cfg.
Make sure the T3400 SATA Operation is set to RAID Autodetect/ATA in the BIOS.
Plug the USB drive in to the T3400 and boot to it.
Using this method I had two T3400s installed and configured in less than 15 minutes.
I hope this helps everyone out. Enjoy.
I am using the usb key to install.
Always response "Unable to find a supported device to write the vmware esx server 3i 3.5.0 image to."
My T3400 BIOS Version is A07
And everyone error log with me the same?
Remember to NOT use RAID or AHCI for your drives, only ATA mode will work.
Jeff Elben: Thanks for that USB boot method. That should help out a bunch of people, since technically that method should work the same as PXE, since it's not using anything on that ATA/SATA bus. Rather an odd problem to say the least. Maybe some sort of IRQ conflict or somesuch between the CD drive and HDD. shrug
And yes, USB would be faster and much easier to set up!
Oh My GOD~~~~
Thank you response.
I've recently setup VMware ESX Server 3i build-123629 (Update 3) on both a Dell Precision T3400 and a Precision 390 BIOS version 2.6.0 (05/19/08)
Seagate ST3160815AS Sata 160GB HD
In the BIOS I set SATA Operation to "RAID Autodetect / AHCI".
It was set to "RAID Autodetect / ATA" and there is also the option for "RAID". I tried the ATA and got the no disk found message during installation.
The CD did work fine in both cases and was able to run the installer all the way up to the disk detection point.
It is working fine on the Net with the on board Broadcom GigE NIC too BTW.
This is the ISO file I downloaded to run install these servers.
VMware ESX Server 3i U3 Installable Refresh
Version 3.5 Update 3 | 123629 md5sum: 444e1f57d1bc2296391b74e9ee406acb(¹)
Hope that helps some of you out there...
I was able to setup esxi 3.5 update 4 on a T3400 by setting SATA Operation to "RAID Autodetect / AHCI".
I was able to find a solution to getting VMWare ESXi version 4.0 installed on a Dell Precision T3400 system & support 64 Bit Virtual Machines. I did not have any problems installing ESXi on the system once I changed the SATA settings to be RAID with ATA functionality if there are not any active RAID drives. I did have problems trying to set up 64 bit VM's on this system though. After reading articles, I determined that it was my processor series that I had installed on my T3400 system. When we purchased the T3400, we selected a low end processor for this system. We had the Intel Core 2 Duo E4600 series processor. You would want to compare your processor with what Intel shows as having the virtualization functionality built into it. The Intel article can be located at http://www.intel.com/products/processor/core2duo/specifications.htm?iid=prod_core2duo+tab_spec for Core 2 Duo processors. Core 2 Quad processors can be located at http://www.intel.com/products/processor/core2quad/specifications.htm.
I replaced the processor with an Intel Core 2 Duo 6300 series process running at 1.86 GHz. The 6300 series does have the Intel Virtualization Technology (VT) functionality. Once I installed the 6300 series processor, I looked in the BIOS. In the Performance tab, there was a new option available for Virtualization. I enabled that feature & then performed a clean install of VMWare ESXi 4.0 on the system.
After finishing the setup, I then started a VMWare convert to move a 64 Bit virtual machine onto the T3400 system. It finally accepted the T3400 as an acceptable location for 64 Bit virtual machines. Prior to processor replacement and SATA changes in the BIOS, I could not perform a VMWare convert targeting the T3400 system. Every time that I tried to select the T3400 system, VMWare convert would come back saying that the T3400 does not support 64 Bit virtual machines.


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Different Payment Methods For Your Small Business. The world's best Another online payment option that some businesses have adopted is Bitcoin. Bitcoin. How should you pay when you shop online: credit card, PayPal (or to paying: will you use a credit card, debit card, a payment service like. If you are not familiar with current practices in e-commerce, you'll need to acquaint yourself with the various methods of online payment and how they work on.
Different payment methods online - erhalten Sie
Kissmetrics Products Pricing Customers About Blog Try Kissmetrics Sign In. If your small business website uses a service capable of processing credit cards from gift card issuers such as Visa and Mastercard, then you will be able to accept this type of gift card. Get our weekly newsletter from SEJ's Founder Loren Baker about the latest news in the industry! Simply register and verify your account and you can start accepting credit card payments, and even PayPal payments. I also never Purchase Product from those websites that Redirect to another party. The most popular e-wallet is PayPal. And right on time. How could we make cdu fdp site better? Of course, credit cards and PayPal are popular payment methods in many parts around the world. To make it more interesting offer some free stuff or freebie on the payment page to surprise the customer and make a psychological. Steve Aug 30, at ALL NEWS Most Read. Follow Rosston on Twitter: For convenience, and the number of users, Google Wallet tops our list of the top 10 online payment solutions. Guest Sep 01, at A PSP with which a business is cooperating may be changed, in this case this "switch" to another payment provider is quick and easy since the business already owns a merchant account. Since almost everyone has an Amazon account, all your important information has already been stored.
Different payment methods online Video
The Best Payment Method according to Ur IndianConsumer ! To make it more interesting offer some free stuff or freebie on the payment page to surprise the customer and make a psychological. You always take a risk when you shop online: Naturally, although evaluating an online site and additionally finding systems to invest in is easy, if for example the monthly payment operation can be troublesome, buyers often start working on a web site making choosing a lot of easier. Chip and signature Security and fraud Mobile phone payments Internet banking Sending money abroad Winter payment tips Can we help? All Content Marketing Content Marketing Guide Content Marketing Email Marketing Youtube. If you've thought about selling a product on your website here are a list of the book of ra android umnet renowned PSPs:. Payments and the design have to be as simple as possible for the users. As mentioned earlier, your checkout page is where window shoppers turn into paying customers. Some merchants ask for create account; it is safe way as usual keep your personal password, create password that is difficult to presume. In this type of a payment solution the focus is on making the process of creating a merchant account, registration, and integrating as easy as possible for sellers. As pointed out earlier, delivering a consistent design and not redirecting people to a third party different payment methods online page are important steps in building trust with potential customers. Control your marketing funnel, every step of the way. Connect Email Newsletter Facebook Twitter Pinterest Google Instagram. Well, an e-business now works on its own account and builds an online payment processing history, which can certainly come in use in future if a business will decide on negotiating better conditions or changing an acquirer. Perhaps you use it regularly for personal and business expenses, and you might pay automatic or recurring charges with the card. Product Finder Volusion, Inc.: How can i integrate many CC Services in my website i am not able to find any good Resource. Never send your payment information via email — Data transmitted over the net as regular mail is not completely protected from being interpreted by third parties.

domain: economics


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Heat oil in large skillet. Add the yellow and red onions and saute over moderate heat 5 min. Stir in wine, add leeks. Saute another 15 min, stir frequently, or until onions are golden and leeks are limp. Remove from heat.
Preheat oven 350F. In mixing bowl, combine beaten eggs with two tablespoons of the parsley, dill, tarragon, feta cheese, and pepper. Stir in the onion mixture.
Oil a 10 in. tart pan and line bottom generously with bread crumbs. Pour in onion mixture. Ring the outside edge with tomato slice, then sprinkle the remaining parsley in the center. Sprinkle a light layer of bread crumbs over the entire top. Bake for 40 to 45 min, or until the mixture is set and top is golden. Let stand for 5 to 10 min, then cut into wedges.

domain: food


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This profile is private and available for friends only.
|My match age||18-25|
|Height||4'7" (140cm) or below, 5'0"-5'3" (151-160cm), 5'4"-5'7" (161-170cm)|
|About myself||I am i single mum and i have a daughter.I like too hang out with friends and family and i like too go out shopping and i like too go out and watch movies. I like anytype of music but i like the new music the most. I love too go out clubbing. I hate sittin at home been bored I would love too get out more but it is hard. I love to get more tattoos I got one on my bak n I love to walk on the beach too.|


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Judith Clingan : Represented Artist
- Browse works by Judith Clingan
- Browse recordings available to purchase featuring music by Judith Clingan
- Browse articles by and about Judith Clingan
- Browse events featuring music by Judith Clingan
Photo: Helen Musa
Artist website: http://www.judithclingan.net.au/about.htm
Judith Clingan A.M. is a multi-faceted artist equally intrigued by sounds, words, movement and things visual. Born in Sydney in 1945, she was not taught music, but spent her childhood singing, playing recorder, drawing, painting, and writing stories and songs. On leaving school, she studied languages at ANU while continuing to indulge her passion for all things creative. In 1967 she founded the Canberra Children's Choir (now Canberra Youth Choir), and, discovering an alarming lack of interesting music for SSA voices, began composing for them. Along the way she studied music part-time, mostly at the Canberra School of Music: voice, bassoon and composition. In 1970 she founded what is now the Young Music Society: for 10 years she directed holiday music schools for hundreds of children. From 1972 - 1974 she lived in Hobart, studying art, painting, teaching and conducting.
Her daughter Jessica was born in 1974. Being the mother of a young child focussed Judith Clingan's attention on the musical education of young children. She studied at the Kodaly Institute in Hungary from 1981-82 and, on her return to Canberra in 1983, she founded the community performance and tuition group Gaudeamus (which morphes into Music for Everyone, which is now a part of Music for Canberra.) For Gaudeamus she composed, and commissioned from other Australian composers, many choral and music theatre works.
In 1989 Clingan was the Creative Arts Fellow at the ANU; in 1991 she was an Australia Council Composition Fellow. Gaudeamus performers toured her music theatre work Kakadu (1990) to Finland and the work won a Sounds Australian award in 1991. In 1991 she became involved with Steiner education, and since then has written many short choral and music theatre pieces for use in Steiner schools. Also in 1991 she was chosen to be the inaugural Canberra Times Artist of the Year.
From 1994 - 1996 Clingan worked in South Australia, founding Voicebox Youth Opera, for whom she wrote many music theatre pieces. She returned to Canberra in 1997, and founded the choir Wayfarers Australia, and the vocal octet Variables. In 1999 she travelled to Europe on a Churchill Fellowship to investigate music theatre; in 2001 she was awarded an artsACT Creative Artists Fellowship. Some of her choral pieces have been released in the CD Choralations; her pieces for use in schools and community groups can be found in the Songs of the Tree of Life books and CDs.
Judith Clingan is currently based in Canberra, composing, conducting, teaching and performing, as well as organising and directing choral and music theatre holiday schools, music education courses, and choral, recorder and music theatre performances. She also makes frequent forays to other parts of Australia and to Europe to teach and perform both old and new music. Currently (2016) she is about to take a group of her international performance troupe Wayfarers to perform in the Edinburgh Fringe - her music theatre version of Saint-Exupéry's Le Petit Prince will receive its premiere at the Fringe.
Judith Clingan — current to June 2016
|Truths? : for SATB choir with violin (2016)
|Commissioned by Rowan Harvey-Martin.
|Es ist ein' ros' entsprungen (sa choir with chamber ensemble) (1994)
|Arranged for Nexus Contemporary Music Ensemble
|Kakadu (sab choir with chamber ensemble) (1990)
|Commissioned by Gaudeamus A.C.T.
|A sparrow's Noel : for children's choir (SSA) and cello or double bass (1990)
|Commissioned by Canberra School of Music Community Choir.
|Lux Mundi : cantata for senior SSA choir, junior choir and school orchestra (1985)
|Commissioned by Fahan Girls' School, Hobart
|Incidental music for 'Under Milk Wood' (sa choir with chamber ensemble) (1981)
|Commissioned by Canberra Girls Grammar School.


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demand-driven interventions, establish more active partnerships with women and young people, and root accountability for the results of RMNCA health eﬀorts in aﬀected communities. More lives can be saved more readily if humanitarian, development, and RMNCA health communities come together and support each other to work in more complementary ways. Cooperation between and across diﬀerent areas of expertise, actors, and systems currently working in parallel is vital to bridge gaps and maximise opportunities for sustained impact in the interests of those most at risk in fragile and humanitarian settings. This approach could deliver a new reality for every woman and every child everywhere in every setting. It is imperative that the Sustainable Development Goals and the next Every Woman Every Child global strategy include clear measures to better support countries and the international community to uphold fundamental human rights across the life course in every setting. This would be an important step towards maximising the opportunities for sustained impact on the health and wellbeing of women, newborn babies, children, and young people whose human rights oblige this of us, and whose potential contribution to their communities’ and countries’ resilience, response, and recovery from emergencies and crises will surely reward such eﬀort. The next Every Woman Every Child strategy will help accelerate eﬀorts to implement the Abu Dhabi Declaration.
*Sarah Zeid, Flavia Bustreo, Maha Taysir Barakat, Peter Maurer, Kate Gilmore Partnership on Maternal, Newborn and Child Health, Geneva 1211, Switzerland (SZ); World Health Organization, Geneva, Switzerland (FB), Health Authority Abu Dhabi, Abu Dhabi, United Arab Emirates (MTB); International Committee of the Red Cross, Geneva, Switzerland (PM); and United Nations Population Fund, New York, USA (KG) [email protected]
We declare no competing interests. © 2015. World Health Organization. Published by Elsevier Ltd/Inc/BV. All rights reserved. 1
Organisation for Economic Co-operation and Development. States of fragility 2015: meeting post-2015 ambitions. Paris: Organisation for Economic Co-operation and Development, 2015. WHO, UNICEF, UNFPA, World Bank, United Nations Population Division. Trends in maternal mortality: 1990 to 2013. Estimates by WHO, UNICEF, UNFPA, World Bank and United Nations Population Division. Geneva: World Health Organization, 2014. UNICEF, WHO, World Bank, UN, UN Inter-agency Group for Child Mortality Estimation. Levels and trends in child mortality report 2014: estimates developed by the UN Inter-agency Group for Child Mortality Estimation. New York: United Nations Children’s Fund, 2014. Plan International. Because I am a girl: the state of the world’s girls 2013. In double jeopardy: adolescent girls and disasters. Surrey, UK: Plan International, 2013. Oestergaard MZ, Inoue M, Yoshida S, et al, on behalf of the United Nations Inter-agency Group for Child Mortality Estimation and the Child Health Epidemiology Reference Group. Neonatal mortality levels for 193 countries in 2009 with trends since 1990: a systematic analysis of progress, projections, and priorities. PLoS Med 2011, 8: e1001080. The Abu Dhabi Declaration. February, 2015. http://www. everywomaneverychild.org/images/The_Abu_Dhabi_Declaration_ Feb_2015_7.pdf (accessed April 27, 2015). Lewis J. Continuum or contiguum? Development for survival and vulnerability reduction. Fifth European Sociological Association Conference 2001; Helsinki, Finland; Aug 28–Sept 1, 2001. 250 (abstr). http://www. dcscrn.org/cms/uploads/esa2001/lewies%20-%20continuum%20or%20 contiguum.pdf (accessed April 27, 2015).
A new ASPECT for complicated urinary tract infections Published Online April 28, 2015 http://dx.doi.org/10.1016/ S0140-6736(14)62482-X See Articles page 1949
Complicated urinary-tract infections are a major cause of bacteraemia and are associated with high mortality rates of 20–40% among critically ill patients worldwide.1,2 Antibacterials with broad-spectrum activity, especially against uropathogenic Gramnegative bacteria, are often used as empirical treatment for complicated urinary-tract infections.3 The increasing prevalence of multidrug-resistant Enterobacteriaceae spp and Pseudomonas aeruginosa among urinary isolates, however, has led to major challenges in the selection of eﬀective antibiotic treatments. For example, the ﬂuoroquinolones comprise a class of antibacterials that have excellent bioavailability and broad-spectrum
antimicrobial activity against most uropathogenic Gram-negative bacteria, including Enterobacteriaceae spp and P aeruginosa. More than 35% of urinary isolates of Escherichia coli collected from patients admitted to hospital in countries across the world, however, are resistant to ﬂuoroquinolones.4 Furthermore, resistance to ﬂuoroquinolones is especially high (more than 50%) among E coli that produce extended-spectrum β-lactamases (ESBL).4 Thus, there is an urgent need for the development of new antibacterials to treat complicated urinary-tract infections. Ceftolozane-tazobactam is a novel combination drug that includes a cephalosporin-β-lactamase inhibitor www.thelancet.com Vol 385 May 16, 2015
with potent activity against multidrug-resistant Gramnegative bacteria, including most ESBL-producing Enterobacteriaceae spp and carbapenem-resistant P aeruginosa.5 A phase 2 clinical trial has shown similar safety and eﬃcacy for ceftolozane alone and ceftazidime in the treatment of complicated urinary-tract infections.6 In The Lancet, Florian Wagenlehner and colleagues7 report their safety and eﬃcacy ﬁndings for ceftolozanetazobactam compared with levoﬂoxacin, assessed in the ASPECT-cUTI clinical programme. This large, international, multicentre, double-blind, randomised, controlled, phase 3 clinical trial was done in 1083 hospital inpatients with complicated lower-urinary-tract infections or pyelonephritis, in 209 centres in 25 countries. Patients were randomly assigned to receive either intravenous 1·5 g ceftolozane-tazobactam every 8 h or intravenous 750 mg levoﬂoxacin every 24 h, both for 7 days. The results conﬁrmed the non-inferiority of ceftolozane-tazobactam to levoﬂoxacin in the microbiological modiﬁed intention-to-treat population of patients who showed growth of one or two uropathogens of at least 10⁵ colony-forming units per mL in urine culture (306 [76·9%] of 398 patients vs 275 [68·4%] of 402 patients, 95% CI 2·3–14·6) and the per-protocol population (284 [83·3%] of 341 patients vs 266 [75·4%] of 353 patients, 2·0–14·0). Adverse event proﬁles did not diﬀer signiﬁcantly between treatment groups. Importantly, ceftolozane-tazobactam was superior to levoﬂoxacin in patients with infections caused by ESBL-producing (38 [62·3%] of 61 patients vs 20 [35·1%] of 57 patients) or levoﬂoxacin-resistant bacteria (60 [60·0%] of 100 patients vs 44 [39·3%] of 112 patients). These results suggest that ceftolozanetazobactam could be a useful new treatment option for patients with complicated urinary-tract infections, especially those caused by multidrug-resistant Gramnegative bacteria. We congratulate Wagenlehner and colleagues for completing this much anticipated and rigorous clinical trial. Looking ahead, several important features of the clinical use of ceftolozane-tazobactam should be assessed further. First, ceftolozane-tazobactam is primarily excreted in the urine and dose adjustment is required in patients with moderate to severe impairment of renal function.8 In Wagenlehner and colleagues’ study,7 patients with severe renal impairment, including those with estimated creatinine clearance of less than www.thelancet.com Vol 385 May 16, 2015
Dr P Marazzi/Science Photo Library
0·5 mL/s per m², requirement for peritoneal dialysis, haemodialysis or haemoﬁltration, and oliguria, were excluded. As patients with complicated urinary-tract infections are prone to develop acute renal impairment, the safety and optimum dosing regimen of ceftolozanetazobactam in this subgroup require investigation. Second, there remains no evidence-based consensus on the duration of therapy for complicated urinarytract infections. The eﬃcacy of the 7 day regimen used by Wagenlehner and colleagues should be compared with alternative regimens, such as those extended to 14 days or beyond.9 Third, since ceftolozanetazobactam has potent activity against P aeruginosa, including multidrug-resistant isolates, whether this drug would be useful to treat nosocomial complicated urinary-tract infections, which are commonly caused by P aeruginosa, should be determined.10 Fourth, clinicians should be aware of the limited activity of ceftolozanetazobactam against other important uropathogenic bacteria, including enterococci and carbapenemaseproducing Enterobacteriaceae spp, such as those producing Klebsiella pneumoniae carbapenemases and metallo-β-lactamases.10 Therefore, urine culture to determine the identity and drug susceptibility of the causative organisms in patients who are not responsive to empirical treatment with ceftolozane-tazobactam remains important. Finally, the judicious use of this new antibacterial and continuous surveillance for emerging resistance towards it in diﬀerent parts of the world are necessary to extend its usefulness as we await the next novel broad-spectrum agent becoming available. 1921
*Jasper Fuk-Woo Chan, Kwok-Yung Yuen State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China [email protected]
JF-WC has received travel grants from Pﬁzer Corporation Hong Kong and Astellas Pharma Hong Kong. K-YY declares no competing interests. 1
To KK, Lo WU, Chan JF, Tse H, Cheng VC, Ho PL. Clinical outcome of extended-spectrum beta-lactamase-producing Escherichia coli bacteremia in an area with high endemicity. Int J Infect Dis 2013; 17: e120–24. Wagenlehner FM, Pilatz A, Naber KG, Weidner W. Therapeutic challenges of urosepsis. Eur J Clin Invest 2008; 38 (suppl 2): 45–49. Hooton TM, Bradley SF, Cardenas DD, et al. Diagnosis, prevention, and treatment of catheter-associated urinary tract infection in adults: 2009 international clinical practice guidelines from the Infectious Diseases Society of America. Clin Infect Dis 2010; 50: 625–63. Hoban DJ, Nicolle LE, Hawser S, Bouchillon S, Badal R. Antimicrobial susceptibility of global inpatient urinary tract isolates of Escherichia coli: results from the Study for Monitoring Antimicrobial Resistance Trends (SMART) program: 2009–2010. Diagn Microbiol Infect Dis 2011; 70: 507–11. Farrell DJ, Flamm RK, Sader HS, Jones RN. Antimicrobial activity of ceftolozane–tazobactam tested against Enterobacteriaceae and Pseudomonas aeruginosa with various resistance patterns isolated in U.S. Hospitals (2011–2012). Antimicrob Agents Chemother 2013; 57: 6305–10.
Umeh O, Cebrik D, Friedland I. A double-blind, randomized, phase 2 study to compare the safety and eﬃcacy of intravenous CXA-101 (CXA) and intravenous ceftazidime (CTZ) in complicated urinary tract infection (cUTI). 50th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy; Boston, MA, USA; Sept 12–15, 2010. Abstract number L1-361A. Wagenlehner FM, Obiamiwe U, Steenbergen J, Yuan G, Diaruiche RO. Ceftolozane-tazobactam compared with levoﬂoxacin in the treatment of complicated urinary-tract infections, including pyelonephritis: a randomised, double-blind, phase 3 trial (ASPECT-cUTI). Lancet 2015; published online April 28. http://dx.doi.org/10.1016/S01406736(14)62220-0. Wooley M, Miller B, Krishna G, Hershberger E, Chandorkar G. Impact of renal function on the pharmacokinetics and safety of ceftolozane– tazobactam. Antimicrob Agents Chemother 2014; 58: 2249–55. Sandberg T, Skoog G, Hermansson AB, Kahlmeter G. Ciproﬂoxacin for 7 days versus 14 days in women with acute pyelonephritis: a randomised, open-label and double-blind, placebo-controlled, non-inferiority trial. Lancet 2012; 380: 484–90. Zhanel GG, Chung P, Adam H, et al. Ceftolozane/tazobactam: a novel cephalosporin/beta-lactamase inhibitor combination with activity against multidrug-resistant gram-negative bacilli. Drugs 2014; 74: 31–51.
Alain Pol, ISM/Science Photo Library
Renal denervation superior to drug therapy in hypertension
Published Online January 26, 2015 http://dx.doi.org/10.1016/ S0140-6736(14)62050-X See Articles page 1957
Despite widespread use of conventional antihypertensive therapy, which eﬀectively reduces blood pressure in most hypertensive patients, a failure to attain target blood pressure levels in about 10% of patients with arterial hypertension suggests a deﬁcit in present strategies, leaving this patient cohort at high risk of cardiovascular and renal disease.1 Although mechanisms underlying the pathogenesis of arterial hypertension are complex and multifactorial, augmented sympathetic activation crucially contributes to hypertension and its adverse eﬀects. Moreover, high levels of muscle sympathetic nerve activity predominantly feature in patients with resistant hypertension despite multidrug treatment.2,3 Renal denervation is a recent development in the management of drug-resistant hypertension that opposes sympathetic activity. Renal denervation has substantial clinical and pathophysiological relevance and a favourable safety proﬁle, resulting in a sustained reduction in blood pressure and sympathetic nerve activity.2–7 Accordingly, since the proof-of-concept study of renal denervation,5 many patients with resistant hypertension and at high risk of cardiovascular and renal disease who underwent renal denervation have
beneﬁted from improved blood pressure control along with attenuation of hypertension-induced end organ damage. Although expectations were high for the randomised controlled Symplicity HTN-3 study,8 surprisingly the trial did not meet its primary (mean change in oﬃce systolic blood pressure from baseline to 6 months in the renal denervation group, compared with the sham-treated control group) or secondary (change in ambulatory blood pressure at 6 months) eﬃcacy endpoints as a result of several conﬁrmed study design issues.9 Although the study included a sham procedure, limitations of Symplicity HTN-3 included ineﬀective or inconsistent renal denervation associated with interventionalists inexperienced in the renal denervation procedure, medication changes both between screening visits and before assessment of 6 month endpoints (in about 40% of patients), variable drug adherence, and an absence of validated tests to conﬁrm renal denervation. These limitations provide a probable explanation for the absence of a signiﬁcant diﬀerence in systolic blood pressure between renal denervation and sham-procedure groups. Despite these study design issues, the reporting of Symplicity HTN-3 has halted renal denervation and further neuroscience research into uncontrolled blood pressure. www.thelancet.com Vol 385 May 16, 2015


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Spring Fling Stamp Set
Create beautiful, whimsical handmade projects with this folk art inspired woodland set. The cute animal silhouettes and floral images work together perfectly, or they can be used separately to create a myriad of different designs. There are also 3 accompanying sentiments which will work well for many different projects.
This is a 4" x 6" clear stamp set containing 32 stamps made in the USA from high-quality photopolymer.
Get the Bundle! (5% off!): Spring Fling Stamp & Die Bundle
Coordinating Die: Spring Fling Die Set
Customer ReviewsWrite a review
I just love this stamp set. I am going to use it with the die set that is in the same line. They can be used all year long.
I passed on these the first time they were featured because i am really not a "cute critter" person. However I have gone back to them a time or three and discovered a more folksy and woodland vibe. Also the silhouette feature makes them perfect for scenes on busier backgrounds.
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domain: design