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Tracking the number of active COVID-19 cases in northeastern Ontario
The number of active COVID-19 cases in northeastern Ont. June 11/21 (CTV Northern Ontario)
SUDBURY -- As the novel coronavirus pandemic continues, CTV News Northern Ontario is continuing to keep track of the number of active cases of COVID-19 in the northeast region. Check back often for daily updates on the number of new, active and resolved cases.
Novel coronavirus infections are reported by public health agencies for residents that live within the districts. In northeastern Ontario, there are five health units.
The number of active cases comes from the total confirmed positive less cases that have been resolved, including deaths.
On April 8, the Ontario government enacted its third stay-at-home orders as COVID-19 infections surged and were starting to overwhelm hospitals. Since then, northeastern Ontario has confirmed 2,271 more COVID-19 infections, with more than half of the cases coming from the Porcupine Health Unit region. The stay-at-home orders expired on June 2.
On May 20, the Ontario government revealed its new three-step reopening plan starting with easing pandemic restrictions on outdoor activities and gatherings after its third state of emergency due to an overwhelming surge of COVID-19 cases and hospitalizations. The province announced it is moving into the first phase on June 11 that will see outdoor dining reopen along with "non-essential" businesses at a reduced capacity. Read more about what will be allowed here. Due to the uncontrollable surge in new COVID-19 infections and the prevalance of the Delta variant, the Porcupine Health Unit has extended the lockdown for an additional two weeks, to expire June 25.
The Ontario government announced on June 2 that schools will continue to be closed to in-person learning until September.
As of June 11 at 4 p.m., there are 381 active cases in northeastern Ontario after 29 new infections were confirmed, along with 39 resolved cases on Wednesday.
Variants of concern (VOCs) have been detected in all five northeastern Ontario health unit areas. While the B.1.1.7 COVID-19 variant, first detected in the U.K., is the dominant strain in Ontario, the B.1.351 strain that originated in South Africa is also circulating in the region. On March 31, Algoma Public Health announced VOCs have been detected in three recent COVID-19 cases, two in the Sault Ste. Marie area and one in the Elliot Lake area. There are now 106 cases involving VOCs in Algoma. There have been variants of concern detected in 931 positive COVID-19 cases in the Sudbury and Manitoulin area and in 154 cases in the North Bay area, including one B.1.617 that was first detected in India and 31 connected to the Lancelot Apartment outbreak. A total of 81 cases involving variants of concern have also been detected in the Timiskaming region, the exact strains have not yet been confirmed. The first VOC case in the Porcupine Health Unit region was detected Feb. 4 and both the B.1.1.7 and B.1.351 have been confirmed in the Cochrane District since then. There have been a total of 818 cases in the Cochrane District that have tested positive for variants of concern.
Here is how the disease rates stand in each of the northeastern health units:
There are currently six active cases of COVID-19 in the Algoma District after two new infections were confirmed in the Elliot Lake area on Wednesday. This after one new infection was confirmed in Elliot Lake and two previous cases were resolved on Friday. There has been a steady decline in the number of active COVID-19 cases in the Algoma region since last week week with only two new cases total and 16 resolved.
The previous week, eight new infections confirmed, down from 14 the previous week, along with 31 were resolved total, including two COVID-related deaths.
Since April 1, there have been 166 new cases confirmed in the Algoma District.
The first shipment of the Moderna vaccine was received on Jan. 27 and long-term care home residents have been vaccinated.
The Algoma District's first COVID-related death happened on Jan. 18. The second happened exactly a week later, the third death was on Feb. 15, the fourth was announced March 1, and the latest happened back-to-back on May 23 and 24.
Since New Year's Eve, there have been 331 new cases of the disease, an increase of more than six times, and 328 have been resolved, including six deaths.
"Anyone who is ill, even with mild symptoms, must stay home and self-isolate away from others," said Algoma Public Health's website. "Do not have close contact with others outside the immediate household of people you live with. Limit non-essential trips outside of home and avoid non-essential travel to other regions of the province."
Since the pandemic began, there have been 396 confirmed positive cases, 390 resolved, including six COVID-related deaths in the Algoma District. The majority of the positive cases, 310, have been in the Sault Ste. Marie area, 51 in central and east Algoma, four in north Algoma and 31 in the Elliot Lake area.
There are currently 26 active cases in the Nipissing and Parry Sound Districts after five new infections were confirmed in Nipissing and three others were resolved. Of the active cases, 26 are from Nipissing and none are from Parry Sound.
The number of new infections being confirmed continues to drop as the current stay-at-home orders are set to expire. In the last seven days, 16 new infections were confirmed and 19 previous cases resolved. Last week, 14 new infections were confirmed, down from 19 the previous week, 32 the week before that and 35 the week before that. Another contributing factor is the 40 previous cases that were resolved last week, bringing the active cases down significantly.
On March 2, the health unit received lab confirmation that two individuals from the Parry Sound area tested positive for the B.1.1.7. variant of concern that originated in the U.K. Both people were exposed through community spread, meaning they did not know exactly where they caught the disease.
"We now have confirmation of two different strains of COVID-19 Variants of Concern in our Health Unit district. This is very concerning as we are seeing community spread," said Dr. Jim Chirico, medical officer of health for North Bay and Parry Sound. "We must all do what we can to help slow the spread of COVID-19 in our community to help save lives and to be able to re-open our economy. It is essential we continue to follow public health measures."
On Feb. 13, officials warned of a new 'cluster of cases' at an apartment complex. The individuals in question were not close contacts, only connected through the address. Health officials say 45 people from Skyline - Lancelot Apartments in North Bay have been infected, but only 38 of them live there full time. A covid variant has been detected in 31 of those cases and 21 of those have been identified as the B.1.351 from South Africa. All of the active cases connected to the building have been resolved and three have died. The first one was on Feb. 17, the second was on Feb. 23, and the third fatality happened on March 1.
Two cases involving the B.1.617 variant, that was first discovered in India, has now been confirmed in the Nipissing-Parry Sound area. The number of confirmed cases involving the B.1.351 COVID-19 variant originating in South Africa has grown to 28, 113 infections were confirmed to be the B.1.1.7, which originated in the U.K., one case involving the P.1. , first detected in Brazil, and 15 other cases in the district have screened positive for a variant of concern and officials are determining which strain they belong to.
Since Christmas Eve, there have been 354 new cases, an increase by almost four times, and 351 cases have been resolved in this same period. During the last stay-at-home order, 165 new infections were confirmed in a matter of weeks.
A total of 53 new infections were confirmed in December, 37 per cent of the total cases since the pandemic began. In November, there were 32 new cases of COVID-19 confirmed, at the time accounting for more than 40 per cent of the total cases in these two districts since the pandemic began.
The North Bay Parry Sound District Health Unit completed administering the first shipment of the Moderna COVID-19 vaccine. This involved 505 long-term care residents and 16 front-line staff at the care homes. To date, 75,358 residents have received at least one dose of the COVID-19 vaccine.
A total of 467 cases have been confirmed in the Nipissing and Parry Sound Districts to date, of which 448 have been resolved, including four COVID-related deaths. Nipissing District has had 297 cases total, while 170 cases are from the Parry Sound District.
The number of active COVID-19 cases in the Sudbury and Manitoulin Districts continues to drop. There are currently 19 active cases of COVID-19 in the Sudbury and Manitoulin districts after two new infections were confirmed in the north part of the Sudbury District and two others were resolved on Friday.
Of the active cases, 14 are in Greater Sudbury, five are in the Sudbury District and none in the Manitoulin District.
In the last seven days, there were 11 new infections confirmed and 19 others resolved. Last week, there were 22 new cases confirmed and 26 previous cases resolved including one death. This is up slightly from 18 new cases the previous week and 37 resolved cases. Also, COVID-19 outbreak was declared at Discovery Early Learning and Care's main site in Garson.
To date, 109,907 people have received at least one dose of the COVID-19 vaccine. Residents ages 12 and older can now book an appointment to get the COVID-19 vaccine.
Public health has started publishing all active outbreaks in the area, not just schools and congregate living settings. There are currently zero active outbreaks in the Sudbury area.
At the beginning of April, there were seven COVID deaths in the area, the most in one week since the pandemic began.
During the last week of March, Public Health Sudbury & Districts recorded 156 new infections and resolved 202 others, including five COVID-related deaths. Of those new cases, 43 per cent tested positive for a COVID-19 variant of concern.
Residents of the Sudbury and Manitoulin District ages 12 and earlier can now book their COVID-19 vaccination appointment at an upcoming vaccine clinic online or by calling the health unit at 705-674-2299.
All Greater Sudbury schools moved to online learning until further notice beginning March 15 due to the rise in the number of new COVID-19 infections.
The first week of March, 109 new infections were confirmed and eight cases resolved, including one COVID-related death on Tuesday.
There have not been any school-related COVID outbreaks in Sudbury since Marcy 26.
During the last week of February, there were 28 new infections confirmed, 17 resolved, including one death and the outbreak at Health Sciences North was declared over. The COVID-related death marked the area's thirteenth fatality due to the disease and the second connected to the outbreak at Health Sciences North.
Between Feb. 12 - 14, 10 new infections were confirmed and 19 previous cases, including one death connected to the outbreak at Pioneer Manor.
The week of Feb. 8, there were 24 new cases confirmed and 36 cases resolved, including one death connected to the COVID outbreak at Health Sciences North.
Feb. 5-7, there were 10 new infections were confirmed and 19 previous cases were deemed resolved, including another death connected to the Amberwood Suites retirement home outbreak.
This after 20 new cases were added over the last weekend in January along with 29 resolved, including two deaths. One of the COVID-related deaths involved a Finlandia resident, while the second involved a resident from Amberwood Suites retirement Home. Marking Sudbury's ninth death since the pandemic began. There have been 10 COVID deaths in the Sudbury and Manitoulin Districts since Jan. 15.
To date, there have been seven COVID deaths connected to the outbreak at Amberwood Suites, which was declared Jan. 5 after a resident tested positive for the disease. Health officials said there are at least 38 cases of COVID-19 linked to the senior's residence in city's South End. Five of those cases involve staff members, while the other 33 are residents.
Since Christmas Eve, there have been 1,856 new cases of COVID-19 and 1,840 resolved, including 28 deaths. This accounts for 88 per cent of the total number of new cases since the pandemic began.
"Self-isolation means not leaving home for work or school, not using public transportation, and avoiding contact with others," public health said.
In November, 104 new cases were confirmed, which accounts for more than 36 per cent of all cases in the Sudbury and Manitoulin Districts since the pandemic began.
A total of 2,113 positive cases have been confirmed in the Sudbury and Manitoulin Districts, 2,094 resolved with 30 COVID-related deaths. The majority of cases, 1,973 have been in Greater Sudbury, while 100 were in the Sudbury District and another 40 were in the Manitoulin District.
As of Friday at noon, there were five COVID-related hospitalizations at Health Sciences North, three of those are in the intensive care unit (ICU), with three patients at the Sudbury hospital having been tested and awaiting results, none of which are currently in the ICU.
A man in his 80s with COVID-19 was transferred from the Timiskaming District to the Sudbury hospital Jan. 8 and passed away the following Monday, marking the first COVID-related death of a Timiskaming District resident.
Porcupine Health Unit (Includes the Town of Hornepayne, which is a part of the Algoma District)
The number of new COVID-19 infections continue to surge in the Cochrane District with a large portion due to variants of concern (VOC), the number of cases involving a VOC has reached 818. There are currently 328 active after 24 new infections were confirmed on Friday and 84 other cases were resolved over the last two days.
Most of the active COVID-19 cases, 193, are in the James Bay coast area, 109 are from Timmins, 21 in the Cochrane/Matheson/Iroquois Falls/Smooth Rock Falls area, one in the Hearst/Hornepayne area, three in the Kapuskasing/Opasatika/Val Rita-Harty/Moonbeam area, as well as one resident was infected outside of the region.
This week, there have been 209 new infections confirmed, down from 272 new infections last week, and the record-breaking week prior to that that saw 284 new infections confirmed - up from 152 new cases the previous week.
Health officials declared a COVID-19 outbreak at Kirkland Lake Gold Detour Lake Mine after six workers tested positive for the disease as a result of workplace spread. There are also active COVID-19 outbreaks at:
- Monteith Correction Facility
- Dutch Love Cannabis in Timmins
Since the Ontario government's current stay-at-home orders went into effect on April 8, the number of cases in the Cochrane district has almost quadrupled. Now, the number of positive cases confirmed is 1,748, up from just 385 more than nine weeks ago during the last round of stay-at-home orders.
Residents in the Cochrane District and town of Hornepayne ages 12 and older can now book an appointment for a COVID-19 vaccination online or by calling the health unit.
Three weeks ago, there were 68 new infections confirmed.
Four weeks ago, there were 70 new cases confirmed and 71 resolved, including one COVID-related fatality.
Five weeks ago, there were 83 new infections confirmed and 31 resolved. Of those new cases, 42 were recorded in the last three days.
This is up from the previous week when the health unit recorded a total of 37 new COVID-19 cases and resolved 17.
Health officials say an infected person can spread COVID-19 starting 48 hours before having any symptoms or testing positive for the disease.
A deadly COVID-19 outbreak at Extendicate Kapuskasing began Jan.7 and ended Feb. 24. A total of 71 people were infected as a result of the outbreak and 16 died. The first death at the long-term care facility happened on Jan. 21 and was the Cochrane District's first COVID-related death since August.
Since Christmas Eve, there have been 1,621 new cases and 1,302 resolved, accounting for 93 per cent of the total positive cases since the pandemic began.
Dr. Lianne Catton, the medical officer of health for the Cochrane District, shared a video message on the Porcupine Health Unit's Facebook page Dec. 8. Watch it here.
Public health officials say there is a continued risk of community spread.
Since the pandemic began, 1,656 cases have been confirmed positive in the Cochrane District and the Town of Hornepayne. Of those, 1,307 cases have been resolved, including 27 deaths.
The Timiskaming District has two active COVID-19 cases after one new infection was confirmed on Wednesday. This after one new infection was confirmed on Saturday.
In the last week, four new cases were confirmed and four cases were resolved. There were zero active cases for several days.
There have been a total of 80 cases involving a variant of concern in the Timiskaming District.
On March 23, the district recorded its second COVID fatality. The first happened on Jan. 11 - a man in his 80s with the disease was transferred to Health Sciences North on Friday and passed away after three days. He was exposed to the disease through close contact with another confirmed case and was tested on Christmas Eve.
There was a slight surge in new cases in March, but they were all resolved. Another surge happened in April and again the first week of May.
The first COVID-related death involving a resident of the Timiskaming District happened on Jan. 11.
Since the beginning of December, the number of COVID-19 cases in the health unit's coverage area has more than ten-fold, rising from 19 to 208. There have been 177 new cases since Christmas Eve, accounting for 85 per cent of the total infections since the pandemic began, and 175 cases have been resolved, including two COVID-related deaths. During the last stay-at-home order, there were 75 new infections confirmed.
Since the pandemic began, there have been a total of 207 confirmed cases in the Timiskaming District, and 206 have been resolved including two COVID-related deaths, one on Jan. 11 and the other March 22.
To date, 20,784 residents have received at least one dose of the COVID-19 vaccine.
Read more about the first wave of COVID-19 in northeastern Ontario here.
Take the government's COVID-19 self-assessment here
Daily school screening tool here
Find an Ontario assessment centre near you here
Get the COVID Alert App without sharing any personal information
The number of active cases in the Porcupine Health Unit as of 4 p.m. May 23 was 378, not 326 as reported. The total reported did not include the 12 new cases confirmed Friday night or the 40 new cases confirmed on Saturday.


SF Skate Park Gets a $200K+ Makeover
The San Francisco Recreation and Parks Department recently rolled out improvements to the Waller Street Skate Park, 751 Stanyan St.,—a project spearheaded by local skaters who helped shape its inclusive design that honors its street skateboarding roots.
The skateboarding area on the eastern edge of Golden Gate Park has been beloved since 2011, despite its cracked surface and markings left over from days as a parking lot. The improvements unveiled today aren’t just a makeover but a transformation of the area from an informal gathering spot to an officially sanctioned skate park. It is the first time in the nation that a city has transformed a decommissioned street into a permitted skate park.
The $218,000 makeover includes a high-quality asphalt repaving topped with acrylic overlay ideal for skating. The park kept its nontraditional spirit with elements meant to mimic the urban skate environment such as k-rails, granite blocks and curbs. A new landscape strip allows skaters to both sit and skate amid trees and shrubs. Many of the new elements were salvaged from Public Works storage by DLX Skateshop—including granite ledges that once lured skaters to Market Street. Old defensive architectural elements that once attempted to stop skaters from grinding the edges and corners were removed.
Funding was largely provided through the 2012 Clean & Safe Park Bond’s Community Opportunity Fund.
“This is a special place in the Haight and Golden Gate Park,” said District 5 Supervisor Dean Preston. “The community really came together – advocacy, vision, and support from the skating community, a collaboration between Rec and Park and Public Works, and the generosity of San Francisco voters, who overwhelmingly approved the 2012 Park Bond that funded these improvements. This park will serve our skate community for years to come.”
“Waller Street has always been embraced by the skating community and their love for the place was really the engine behind our renovation,” said San Francisco Recreation and Park Department General Manager Phil Ginsburg. “The result is a park that is challenging enough for the veteran skater and safe for someone just learning to ride.”
Justin Marks of Low Key Skate Shop, the force behind establishing the skate park more than a decade ago, also worked to guide its renovation.
“Growing up in this neighborhood, I’d go home after school, grab my board, and skate the DMV and roll around Golden Gate Park. It was great but we always wondered why we didn’t have skate parks,” Marks said. “Now we have this beautiful skate park here and the cool part is it’s flexible and urban space that’s also part of Golden Gate Park.”
“To work on this project with the city was an absolute dream. This is the future of skateboarding. You are witnessing it here and now. Any city can do this,” said Ashley Rehfeld of DLX.
“Waller street is a model of efficiency, effectiveness, and community, said Alec Beck with the Skate Park Project, Tony Hawk’s national skate park charity. “We hope for this to become the model for other municipalities.”
We rolled out improvements to Waller Street Skate Park today—a project spearheaded by local skaters who helped shape its design to honor its street skating roots. It is the first time in the nation that a city has transformed a decommissioned street into a permitted skate park. pic.twitter.com/0tqVwWfjzm
— San Francisco Recreation and Park Department (@RecParkSF) October 26, 2022


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243 Aviaiton is pleased to present this fast fun and economical aircraft fitted with a 0-235, its capable of 140knts at 23-24 litres per hour with an excellent range
We have here a beautiful example of a Pulsar XP. A fast economical two seat light aircraft cruising at 120knts at 15l/ph
Here we have a beautiful example of a a Vans RV9. Built in 2009 and shipped to the UK she has only had one set of owners.
An opportunity to own one of the finest primary aerobatic trainers ever built along with spares and spare engine.
A lovely example of a C150, a perfect time builder for hour builders and would make a brilliant first group aircraft.
Click here to add your own content, or connect to data from your collections.

domain: hobby


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When Thomas Harrison deeded two and a half acres of his land to the public good in 1779 the City of Harrisonburg was born.
Harrison, the son of English immigrants, brought his family to settle in the Shenandoah Valley in 1737. By 1778 the Harrison family had laid claim to land in the area that is now Harrisonburg and part of Rockingham County. Harrison built a home on Bruce Street that is still standing today. The Commonwealth of Virginia officially organized Rockingham County in 1778.
The following year Harrison deeded two and a half acres of his overall holdings to the new county, which used the property to build the first courthouse on what is still Court Square. The next year an additional 50 acres were added from the Harrison holdings to the two and a half acres and Harrisonburg was recognized as the county seat of Rockingham. In 1780, the city limits were Federal Street to the east, Bruce Street to the south, High Street to the west and Wolfe Street to the north.
In 1789 the Masonic Order was formed in the City, making it the oldest organization still in existence in Harrisonburg.
Trustees governed the City of Harrisonburg until 1849 when a new charter instituted a mayor-council form of government and Isaac Hardesty was elected the City’s first mayor. Hardesty’s council consisted of seven men representing the seven hundred citizens of the young city. In that year Harrisonburg had 200 taxpaying residents and a budget of 237 dollars. (View the history of Harrisonburg City Council members.)
War came to the valley and to Harrisonburg between 1861 and 1864. The City was passed through by both Union and Confederate troops. On June 20, 1862 the fence around the courthouse was used as a stockade to hold Union soldiers taken prisoner in the Battle of Cross Keys. The war was a tense time in the City. Turner Ashby, a noted cavalry officer was killed close to the town’s borders. While Harrisonburg and Virginia were part of the Confederacy, the City of Harrisonburg’s representatives in Richmond opposed secession.
Another 1,082 acres were added to the City in 1892 through annexation. The move increased the population of Harrisonburg by three times to about 2,000 total residents. The next year the town elected trustees to work with the Superintendent of Public Instruction to form a public school system.
The Virginia General Assembly established the State Normal and Industrial School for Women at Harrisonburg in 1908. The school became the State Teachers College in 1924 and was renamed Madison College in 1938. In 1977 the college took on the name of James Madison University (JMU). Today JMU has over 19,000 students and employs nearly 4,000 faculty and staff members.
1912 saw the founding of Rockingham Memorial Hospital (RMH). The hospital serves a five county area spanning the Shenandoah Valley and parts of West Virginia. In 1994, RMH added a regional cancer center to its list of services to the community.
In 1916, Harrisonburg was incorporated as an independent city. Four years later, the 1920 census recorded the population of Harrisonburg as 5,875.
What would become Eastern Mennonite University (EMU) was founded in 1917 as the Eastern Mennonite School. The school became a four-year degree conferring institution in 1947. EMU now has an active graduate school along with undergraduate and adult degree programs.
Through annexations in 1937, 1938 and 1950 about 320 acres were added to the City and two small annexations in 1965 and 1970 brought the total land in Harrisonburg to 3,828 acres or nearly six square miles. The 1970 census recorded Harrisonburg’s population as 19,700.
The last annexation of land by the City was in 1982 when 11.64 square miles were added, bringing the City to 17.394 square miles or 11,132.16 acres.
Efforts toward the revitalization of downtown Harrisonburg went into high gear in the early 2000’s. Through the work of groups like Harrisonburg Downtown Renaissance and with the help of the city government, Harrisonburg is now a Virginia Main Street Community. The City also has a National Historic District and a State Historic District.
According to the US Census, Harrisonburg's population grew from 40,468 in 2000 to 48,914 in 2010, making Harrisonburg the 12th largest city in Virginia.
More resources on the history of Harrisonburg:
For more information about Harrisonburg's rich history, visit our Tourism Office online or in person at the Hardesty Higgins House at 212 S. Main Street, Harrisonburg, VA 22801.
History of public safety in Harrisonburg:

domain: geography


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To produce the Pinot Nero Alto Adige DOC Franz Haas fermentation took place in open top, stainless-steel tanks with a long maceration and frequent punching down of the cap. This enabled the extraction of colour and fragrances from the skins. Ageing took place in small oak barriques for one year, followed by five to ten months in bottle before release.
Grapes for the Pinot Nero are grown on the slopes of Pinzano and Gleno in the Montagna area and in Mazzon in the municipality of Egna. The three different vineyard sites are all south-west facing and range from 350-900 metres in altitude. Soils are extremely varied within this small area, ranging from clay in one vineyard to sand, limestone or gravel in a neighbouring one. Density of planting is between 8,000-12,500 vines per hectare. Low yielding clones of Pinot Nero have been selected for this wine.
The Haas family has been growing grapes in Montagna in the province of Bolzano for generations. However, it was only with Franz, the current proprietor, that they began to produce and bottle quality wines. Franz studied at Geisenheim in Germany before working as a broker of Italian wines in the German market. After several years, he took over the running of the family business. Franz Haas goes to tremendous lengths to grow quality grapes and strives to preserve the flavours of the fruit during winemaking. As a result, the wines that he produces are infused with great character, with purity and balance on the palate. To maintain the aromatic quality of his wines, Franz Haas has bottled his entire production under screwcap from the 2018 vintage onwards. A revolutionary choice, he is one of the first Italian wine producers to have done so.

domain: agronomy


Eisenhower-Khrushchev Meeting 50th Anniversary
The Eisenhower Institute at Gettysburg College commemorated the 50th anniversary of Soviet Premier Nikita Khrushchev meeting with President… read more
The Eisenhower Institute at Gettysburg College commemorated the 50th anniversary of Soviet Premier Nikita Khrushchev meeting with President Dwight Eisenhower at his farm in Gettysburg.
Susan Eisenhower and Sergei Khrushchev held a discussion moderated by Daun van Ee, co-editor of the Eisenhower Papers. They spoke about their memories of the visit and the political implications. They also responded to questions from members of the audience.
This concluding event of the weekend was at 8:00 p.m. on September 26, 20009, at the Majestic Theater. close
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- Daun Van Ee Specialist Library of Congress->Manuscript Division
President Eisenhower's Grandchildren
President Dwight D. Eisenhower’s grandchildren gathered for a family discussion at Gettysburg College about his…
50th Anniversary of Stalin's Death
Scholars and former government officials talked about the death in 1953 of Soviet Premier Joseph Stalin and the impact…
U.S.-Soviet Relations Under Eisenhower
Professor Khrushchev talked about relations between the U.S. and the Soviet Union during the 1950s. He detailed the…
After Words with Peter Carlson
Peter Carlson talked about his book K Blows Top: A Cold War Comic Interlude, Starring Nikita Khrushchev,…


January 27, 2021 By Catrin Einhorn The New York Times
In just the last half-century, humans have caused a staggering, worldwide drop in the number of sharks and rays that swim the open oceans, scientists have found in the first global assessment of its kind, published Wednesday in the journal Nature.
October 30, 2020 By Emma Bryce Anthropocene Magazine
Researchers calculate that protecting just 5% more of the ocean could boost fisheries by as much as 20%.
August 17, 2020 By Ian Urbina Yale Environment 360
After exhausting areas close to home, China’s vast fishing fleet has moved into the waters of other nations, depleting fish stocks. More than seafood is at stake, as China looks to assert itself on the seas and further its geo-political ambitions, from East Asia to Latin America.
July 6, 2020 By Helen Scales The Guardian
Why did dolphins get Flipper while sharks got Jaws? These majestic, diverse animals bring balance to the ocean ecosystem – and they’re in grave danger.
May 5, 2020 By Jordi Boada oceanographic
Deserts are among the most impressive landscapes on earth. The loneliness and vastness of terrestrial deserts have attracted explorers since ancient times, succumbing to their bleakness. But I never imagined deserts like this could exist underneath the surface of the ocean.


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Oil, Gas and Consumable Fuels
Company Overview of Escopeta Oil Company, LLC
Escopeta Oil Company, LLC, an independent oil company, engages in the exploration of oil and natural gas. It also owns oil and gas leases in the Cook Inlet Basin, Alaska. The company is based in Houston, Texas.
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To contact Escopeta Oil Company, LLC, please visit --. Company data is provided by Capital IQ. Please use this form to report any data issues.

domain: economics


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A family man Marco is one of the last good men in a corrupt and apathetic police force that is out-gunned by the powerful drug cartels. CLICK HERE TO PURCHASE THE FILM.
The story of a young woman with the weight of a generation on her shoulders.
The bridge film. Having survived her own suicidal struggles Jazz Thornton is a mental health activist fighting to change how society and the system are dealing with young people like her. Filmed over the course of a year it captures a number of suicides and features interviews with the friends and family of some of the people identified to have jumped from the bridge. Inspired by a New Yorker story Jumpers written by Tad Friend director Eric Steel decided to train cameras on the Golden Gate Bridge over the course of 2004 to capture the people who attempted to leap off the famed structure the site of more suicides than anywhere else in the world.
2017 TV-14 1h 58m Dramas. With technology doing the. Created by Elwood Reid Björn Stein Meredith Stiehm.
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When a body is dumped on the bridge that spans the El Paso-Ciudad Juárez border Ruiz is forced to work with his American counterpart Detective Sonya Cross 2013. Before the Bridge presented by 72U in association with 72andSunny and Hecho aims to inform audiences and start a discussion. Documentary about one of the worlds most popular suicide spots the Golden Gate Bridge in San Francisco.
MOST the Czech word for The Bridge is a fitting title for this 21st-century parable about a loving father his young son and the fateful day when they a. Ultimately this is a film about hope. Watch The Bridge 2006 online.
Palm Springs and other international competitions before receiving an Oscar nomination as Best Live Action Short Film in 2003. The film the Church of Scientology wanted to disappear. Directed by Eric Steel.
The Bridge is a 2006 British-American documentary film by Eric Steel spanning one year of filming at the famed Golden Gate Bridge which crosses the Golden Gate entrance to San Francisco Bay connecting the city of San Francisco California to the Marin Headlands of Marin County in 2004The film captured a number of suicides and featured interviews with family and friends of some of the. With Eric Geleynse Chris Brown Susan Ginwalla Caroline Pressley. Bernhard Wickis astonishing The Bridge was the first major antiwar film to come out of Germany after World War II as well as the nations first postwar film to be widely shown internationally even securing an Oscar nomination.
Set near the end of the conflict it follows a group of teenage boys in a small town as they contend. 769 10 from 202 users. Why have more people chosen to end their lives there than anywhere else in the world.
Troll Bridge is a 28-minute short film based on the Discworld story originally published in After the King and now available in A Blink of the Screen After the King for which this was written was an anthology in honour of J. The Bridge EP 1 Eng Sub – When a dead body is found on the Tuas Bridge left right on the border between Malaysia and Singapore two ICD officers from each country Officer Megat from Malaysia and Officer Serena Teo from Singapore must work together to solve the crime. Outside the theatre MinaCarole Bouquet and her 15-year old son run.
A Yoruba prince and a young lady from a prominent Igbo family face tribal prejudice and parental pressure when they secretly wed. Tolkien rather than being an attempt to trespass in Middle Earth but it seemed to me that there was a mood I could aim for. 2006 feature film directed by filmmaker Brett HanoverA fictional story of involvement and disillusionment with Scientology the film explicitly uses Scient.
But this case is far more complicated than either of them could have suspected and they soon learn that the killers plan. Director Eric Steel and his crew spent an entire year staring at the Golden Gate Bridge trying to unlock the mystery of its darkest secret. The Girl on the Bridge.
Interviews with the victims loved ones describe their lives and mental health. Chidinma Ekile Ademola Adedoyin Kunle Afolayan. Most is Czech for The Bridge.
Running cameras for almost every daylight minute. Filmmakers use hidden cameras to capture the various suicide attempts at the Golden Gate Bridge – the worlds most popular suicide destination.

domain: entertainment


text:
The late great naturalist and writer Stephen Jay Gould, in his book Wonderful Life, once put forward a thought experiment that he called 'Replaying life's tape'. In this he stated that if you were somehow able to rewind the entire evolution of our planet to its start and press 'play', the likelihood of it leading to the evolution of life as we know it today is remote. Our very existence is based upon a million billion tiny chance events and advantageous mutations. Only one in every 1000 species survives and there have been several Mass Extinction Events (MEEs or sometimes called Extinction Level Events). Everyone knows that there was an MEE around 65 million years ago that polished off the dinosaurs and their cousins, but that was nothing compared to the Permian Era MEE that wiped out 95% of all species on the planet. And that was just one of several such events. So we're pretty lucky to be here.
Of course, whatever life had evolved during each 'replay' would still have had to follow the rules of Darwinian evolution, namely that:
- In a given environment, all organisms produce more offspring than can survive to then reproduce themselves.
- All organisms naturally vary.
- Offspring inherit characteristics from their parents and tend to be more like their parents than others.
- At least some of the variations in an organism lead to a greater number of its offspring surviving and reproducing relative to the offspring of others.
- This 'natural selection' means that these particular variations will become more prevalent in the population (as a consequence of the differential survival and laws of inheritance) as they are passed on to future generations.
Creatures adapt to their environments and are shaped by them. They are also shaped by their lifestyles and by sexual selection and there is often a fine balance between the two. Take the peacock's tail as an example; on the one hand, the bird has to be able to escape from predators, but on the other it needs to attract a mate. The peacock is a creature that is absolutely on the edge when it comes to balancing those two factors.
The creatures in these photographs look alien to us because the environment that they evolved to survive in is so alien; pitch black darkness, freezing temperatures, low oxygen, minimal food, crushing pressures ... it is like being on another world. But these creatures, bizarre as they are, have all evolved from the same primitive creatures that we did. They are all based upon carbon and use DNA. Aliens may be based on other elements and have an entirely different system of genetics. Even if the world they inhabit is Earth-like, what are the chances of evolution - with all of its chance mutations and billions of variations - arriving at anything that looks vaguely like an Earth species?
Suddenly the idea of little green men seems incredibly unlikely doesn't it?
The Deep: The Extraordinary Creatures of the Abyss by Claire Nouvian (ISBN: 978-0-226-59566-5)
And some great sea-life image sites worth visiting:

domain: biology


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text:
I know that the Government's moves to reform the planning system caused some concern locally. It's not surprising that in such a beautiful county people should be anxious - as I am - to protect the countryside.
I think the principle of sweeping away the top-down housing targets and returning power to local communities is the right one.
But some feared that streamlining planning guidelines might put the countryside at risk.
There were particular concerns about the "presumption in favour of sustainable development", and that local councils would not have time to put a plan in place to prevent speculative applications by developers.
The final National Policy Planning Framework was published on Tuesday and I am pleased that the redrafted document puts those fears to rest.
The Chief Executive of the Campaign to Protect Rural England said it was "a good day for those who value the character of our towns, cities and countryside" and the Director-General of the National Trust said that the changes "improve the document and give it a better tone and balance."
The new policy has three fundamental objectives: to put power over planning into the hands of communities; to help create the homes and jobs the country needs; and to protect and enhance our natural and historic environment.
It acknowledges that "sustainable development" embraces social, environmental and economic objectives, and that none of these can be pursued in isolation of the others.
It also explicitly recognises the intrinsic value and beauty of the countryside, whether or not it is designated landscape such as the National Park; it encourages a ‘brownfield first' policy for new building, and it makes it easier for councils to stop ‘garden grabbing'.
Most importantly, the policy is clear that the Local Plan is the basis for decisions in the planning system, and it gives councils twelve months to put them in place.
The task now is for our villages to complete their plans in which all members of the community will have a say. The new system puts local people in control.
It doesn't mean that we can, or should, say 'no' to every development. But it does mean that communities themselves can take responsibility for getting the local balance right.

domain: sociology


Recycled steel water tank
An old water tank was saved from a construction site, sliced and transformed into planters. When the planters are empty they can be rolled into place. With only a small surface area in contact with the ground the planters are easy to turn to control the amount of sun.
Photo Credit: Tom Bonner


Holding humans as the hostage is scary. But what is even scarier is holding resources hostage during riots and conflicts. When resources are blocked by the anguish protesters, the effects can be felt in the entire district, city or even state. Imagine, protestors cutting water supply of the entire city.
But, why do protestors resort to these tactics? It’s simple, to get the attention of the government and get their demands met.
Here are 5 essentials of life that were held hostage during such riots:
Water being the essential need of people, is an easy target for the protestors. And that’s exactly what the Jat community did in 2016. The community cut the water supply from the canal which supplied water to most of Delhi. The angry protestors broke the canal’s gate and damaged the operating system. Results? A whopping 10 million Delhiites without water. Unfulfilled promises of the government to provide reservations under OBC led to this move. Likewise, the farmers in Aurangabad (Maharashtra) blocked the water supply of the city.
This lead to a physical fight during which two police inspectors were hurt. The farmers were demanding proper compensation for their land which was used for the construction of Gokul barrage along with a government job for one member of the family.
This year, the Dalit protests in Pune and Mumbai lead to huge public damage, out of which, transport was badly hit. The clash between the Dalits and upper class, mainly Marathas, led to serious communal tension and death of a Dalit. This angered the entire community. They soon took hostage of the lifeline of Mumbai- local trains. The protestors blocked the tracks and attempted a rail blockade. This hampered the entire railways and road traffic. The roads, including the Mumbai Pune highway, was blocked which paralyzed various areas in Maharashtra. Not just the trains, several public buses too were damaged. The state transport buses suffered a loss of 20 crore due to the statewide bandh.
3. Daily necessities
What happens when daily necessities are hampered with? Umm…higher prices, confused citizens and enough mayhem to get the attention of the government and public.
In June 2017, the farmers (Kisan Kranti Jan Andolan) in Maharashtra disrupted the milk supply in the state to get their demands fulfilled. Apart from spilling milk on the road, many other agricultural products too like fruits, vegetables and food grains were held as hostage. This led to a sharp dip in the wholesale markets causing a shortage of these daily essentials. The markets in cities Nashik, Aurangabad and Ahmednagar were completely shut. The days which followed saw a 100% rise in the vegetable prices. This also led to confusion among many consumers, who were buying more supplies to avoid paying higher prices later.
4. Sources of energy
With their demands falling on deaf ears, the farmers in Rajasthan took the step to block the power supply as the last resort. The farmers in that area had been demanding better power supply for agricultural purposes.
Another such a protest included holding back the supply of coal, a source of energy that is needed for a lot of purposes like electricity, running factories and so on. Half a million miners forcibly shut down CIL’s coal mines that are responsible for 80% of India’s coal supply. The miners were protesting against the government’s move to commercialize mining of coal. This strike has chilling impacts in several industries dependent on coal and led to power cuts with a daily loss calculated to approximately Rs. 1500 crore.
In 2017, the state of Madhya Pradesh faced one of the worst farmer’s agitations. The farmers forced the administration to cut down the internet connections. As a result, mobile internet was cut down in 3 districts in MP.
But however, this move proved to be a nightmare for many students in the state. There were course enrolment deadlines, online entrance tests and merit lists, which the students were unable to access. As there was a pressing demand for internet, the online kiosks hiked the prices from Rs. 50 to Rs.300. Soon, access to social media apps like Whatsapp too was curbed, making the situations worst.
With rising disruption of livelihood and sentiments, concrete measures should be taken by the government and the people. While the government has been neglecting the demands of the masses, people end up protesting or facing the burden of the outcome. Both government and the state should work in coordination with each other by not neglecting the demands but providing real time solutions while supporting resource management.


MIAMI—The Miami Heat went small, and came up big.
With that, another Game Seven awaits.
Goran Dragic scored a postseason career-high 30 points and Dwyane Wade added 22, as the Heat rode a small lineup to a 103-91 victory over the Toronto Raptors on Friday night, tying their Eastern Conference semifinal series, 3-3.
“Last year at this time, we were all on vacation,” Miami Coach Erik Spoelstra said. “So often in this business, people tend to want to search for the easy route. There’s usually not an easy way in a seven-game series, certainly not with a second and third seed going against each other. This is the path…, and now we’ve pushed it to a Game Seven.”
It comes on Sunday in Toronto. The winner will head to Cleveland for Game One of the Eastern Conference finals on Tuesday night. Both the Heat and the Raptors won a Game Seven in the first round.
Kyle Lowry scored 36 points for Toronto, on 12-for-27 shooting. DeMar DeRozan added 23 for the Raptors, but their teammates combined to shoot 14-of-34 from the floor and manage 32 points.
“We came here to try to win the game,” Raptors Coach Dwane Casey said. “We didn’t come here with a seven-game series in mind. It’s been a great series, they’re a championship-caliber team, well-coached team, but we came in here to try to win the game.”
Joe Johnson had 13 points, Justise Winslow added 12, and Josh McRoberts scored 10 for the Heat.
Dragic shot 12-of-21, Wade blocked a game-high three shots and the Heat—despite some serious size deficiencies with injured starting center Hassan Whiteside still out—only lost the rebounding battle 43-41.
“I knew [Dragic] was going to have an amazing performance tonight,” Wade said. “You could tell he was on the brink of one.”
Neither team divulged its starting lineup until warm-ups were under way. The Heat had reason for subterfuge, after choosing a super-small starting five of Dragic, Wade, Johnson, Luol Deng and Winslow.
The results? Splendid.
The Heat used eight players—the tallest being McRoberts, at six-foot-10. The average height of the others was just under six-foot-six.
Deng jumped center and Winslow got his first playoff start, three games after sitting out Game Three entirely. The Heat like using the term “positionless basketball” and Winslow epitomized it early—in a 60-second span, the rookie guarded Raptors center Bismack Biyombo, brought the ball up like a point guard and made a corner 3.
“Justise did an amazing job,” Dragic said.
Whiteside, watching from the locker room, was thrilled.
“The guys played really well,” said Whiteside, who will fly with the Heat to Toronto, but said he would not play on Sunday. “Goran got in the paint a lot and made it tough on their guys and D-Wade did D-Wade stuff.”
Dragic scored 14 in the second quarter, helping Miami take a 53-44 lead at the half. The lead got to 13 in the third, Dragic again coming up big with a three-point play, followed by a jumper. And when Toronto got within six early in the fourth, Dragic and Wade scored the next six points to keep Miami in control.
Miami is 6-3 all-time in Game Seven, having won four straight ultimate games (0-1 on the road). Toronto is 1-2 in Game Seven, 1-1 at home.
Image credits: AP


“Reefer containers” are another term for refrigerated storage containers that may be transported and stored in a temperature-controlled environment. They were originally designed for intermodal freight transportation and to transfer temperature-sensitive or climate-controlled goods across international boundaries. However, shipping containers are no longer only utilised for international transportation, as more and more organisations and people are discovering new applications for these containers.. Despite their name, they have the capacity to sustain a temperature that is either warm or cool, depending on the situation. These devices can handle temperatures ranging from -85 degrees Fahrenheit to more than 100 degrees Fahrenheit inside.
What Is the Difference Between Them?
A wide variety of temperature settings may be achieved with the use of reefer containers. T-flooring, insulated walls, and either integrated or external cooling systems are often used in their operation. Choosing the food storage containers malaysia is essential there.
A one, integrated piece
In today’s world, almost all refrigerated storage containers have some kind of temperature control system built in. These are inserted into the container to keep the contents at a predetermined temperature. It will be impossible to recharge an integrated device without an external power source, which is also known as a “reefer point,” in the future.
When the device’s internal power source is active and running, it extracts warm air from the container and vents it to the outside world. If you wish to raise the temperature, it will flow warm air into the container instead of doing the opposite. You must guarantee that there is a constant flow of air around the container in order for this technique to be effective. There must be a water cooling system in place if you want to utilize the container in an area where there is no consistent flow of air.
External or clip-on devices
In the case that a reefer container is unable to reach a “reefer point” for an extended period of time, an external diesel generator may be employed. It would be simple to attach the generator to the container’s outside. This allows air to enter and exit the container through ductwork or portholes put in the container. Refrigerated storage containers frequently include insulation on the interior. This helps to keep the container’s temperature stable.
Metal or aluminium T-flooring is utilised in refrigerated storage containers in lieu of the plywood floors seen in typical storage containers. In a nutshell, it works by producing a raised floor within the container, which raises the container’s contents slightly above the ground below. Consequently, there is a constant flow of either cool or warm air underneath.
Because of the T-floor architecture, these containers cannot always be used as residential or business space without first undergoing structural changes. This is because the metal slats in T-floors have gaps between them, which may catch the legs of furniture and shoes and hold on to grime. It would be necessary to cover the T-floors with a new kind of flooring if the reefer container was to be utilised as a home or office. First, the T-floors would have to be resurfaced. Remove the T-flooring entirely if you choose.


text: Open in another window Figure 1 Literature search results show increasing interest, albeit at different growth rates, in both epigenomics (left axis) and repetitive elements (right axis) over time. The term epigenetics was popularized in the early 1940s by developmental biologist Conrad Waddington (1940) to explain the interactions of genes with their environment, which bring the phenotype into being. In the 1970s, Holliday and Pugh (1975) first proposed covalent chemical DNA modifications, including methylation of cytosine-guanine (CpG) dinucleotides, as the molecular mechanism to explain Waddington’s hypothesis. The revelations several decades later that X inactivation in mammals and genomic imprinting are regulated by complex and multifactorial mechanisms (Monk 1988; Willard et al. 1993) resulted in an updated definition, describing epigenetics as heritable changes in gene expression that occur without a modification in DNA sequence, like the modification of DNA methylation and chromatin remodeling (Wolffe and Matzke 1999). The genomics revolution inspired the investigation of genome-wide rather than local gene analyses, and the term epigenomics was coined as the study of the effects of chromatin structure including the higher order of chromatin folding and attachment to the nuclear matrix, packaging of DNA around nucleosomes, covalent modifications of histone tails (acetylation, methylation, phosphorylation, ubiquitination), and DNA methylation (Murrell et al. 2005). Finally, evidence that demonstrated the resistance of certain gene loci to methylation reprogramming during embryogenesis uncovered that epigenetic adjustments could be inherited not merely mitotically but also transgenerationally (Lane et al. 2003; Morgan et al. 1999; Rakyan et al. 2003). DNA methylation may be the most widely studied type of epigenetic modification and occurs within the one-carbon metabolic process pathway, which depends upon many enzymes in the current presence of micronutrient cofactors, including folate, choline, and betaine derived through the dietary plan. In mammals, DNA methylation is mainly a well balanced repressive mark bought at cytosines in CpG dinucleotides; nevertheless, its regulation is certainly more powerful than previously thought (Maunakea et al. 2010). For instance, recent evidence for methylation of non-CpG cytosines in human embryonic stem cells suggests that methylation at non-CpG sites may be important to developmental homeostasis (Lister et al. 2011). It has been documented that CpG dinucleotides are greatly underrepresented in mammalian genomes because of spontaneous deamination of 5-methylcytosine to thymine and subsequent fixation in a populace over evolutionary timescales (Holliday and Grigg 1993). Thus, nearly all unmethylated CpG sites take place within CpG islands, thought as discreet areas that contains a preponderance of CpG articles (Deaton and Bird 2011). The resulting uneven distribution of CpG islands is certainly thought to derive from uniform genomic CpG site deamination and transformation in conjunction with the regeneration of fresh CpG islands found in repetitive elements with expansion by retrotransposition (Xing et al. 2004). Normally, CpG islands are located within or near gene promoters or in the 1st exons of housekeeping genes. In contrast, the body and regulatory elements of repetitive DNA sequences, such as transposable elements, are methylated, as a result inhibiting the parasitic transposable and repetitive elements from replicating by transcription. Of important note, however, not all animals use DNA methylation as a gene repression mechanism; for example, the model organisms fruit fly ( em Drosophila melanogaster /em ) and roundworm ( em Caenorhabditis elegans /em ) absence appreciable DNA methylation, whereas other bugs and nematodes perform preserve DNA methylation machinery (Gutierrez and Sommer 2004; Maleszka 2008). Epigenetic manipulation of cellular phenotype can be motivated by alteration of chromatin structure by covalent histone modifications and incorporation of histone variants in to the nucleosome (Saha et al. 2006). Chromatin is normally a nucleoprotein complicated that deals linear genomic DNA through a range of nucleosomes. Each nucleosome includes about 147 bottom pairs of DNA coiled around an octamer of histone proteins. Each octamer includes two copies each one of the four primary histones, H2A, H2B, H3, and H4. Chromatin could be additional altered by association with linker histones, histone variants, and non-histone proteins in addition to myriad posttranslational adjustments of histone proteins, which includes histone acetylation, methylation, ubiquitination, phosphorylation, and ADP-ribosylation (Caiafa and Zampieri 2005; Cheung and Lau 2005). Histone acetylation is normally connected with transcriptional activation as the affinity of histone proteins for DNA is normally decreased and chromatin product packaging is calm. Histone methylation outcomes in various transcriptional consequences depending on histone quantity and the lysine residue modified (Kouzarides 2007). Each lysine residue may be methylated in the form of mono-, di-, or trimethylation, adding enormous complexity to the histone code (Jenuwein and Allis 2001). Furthermore, histone modifications interact with DNA methylation patterns to recruit multi-subunit chromatinCprotein complexes, adding another layer of complexity to epigenetic gene regulation. For example, in this problem, Kim and Kim (2012) examine protein complexes influencing epigenetic mark placement. Two histone marks in particular, H3K27 trimethylation and H3K9 trimethylation, are well-characterized repressive chromatin marks important in genic and nongenic regions of the metazoan genomes, but the mechanisms by which these marks are targeted are not wholly understood. Herein Kim and Kim provide evidence that in mammals H3K27 and H3K9 trimethylation mark distinct regions of the genome, whereas the repressive polycomb repressive complex 2 histone-modifying complex works in concert with DNA-binding proteins such as JARID2, AEBP2, and YY1 to target histone modifications. Specifically, deep sequencing approaches, including chromatin immunoprecipitation-seq sequencing, are used to judge the genome-wide distribution of histone modification marks in mammals. Vulnerable Time Points DNA methylation and additional epigenetic patterns are inclined to change through the entire life program, especially during reprogramming occasions connected with normal advancement and aging (Fraga et al. 2005; Hajkova et al. 2002; Martin 2005). For instance, the epigenome is specially dynamic during embryogenesis due to intensive DNA synthesis, and the elaborate DNA methylation patterning necessary for normal cells development is made during early advancement (Faulk and Dolinoy 2011). As people age, gradual DNA hypomethylation occurs at the genome-wide level, concurrent with locus-specific promoter increases in DNA methylation at normally unmethylated CpG islands, leading, for example, to genome instability or gene-specific suppression, respectively (Mugatroyd et al. 2010). Additionally, compared with normal tissue, cancer is often associated with hypomethylated DNA and notable hypermethylation of tumor suppressor genes (Feinberg 2007). These reprogramming events throughout the life course result in tissue-specific DNA methylation patterning (Hajkova et al. 2002; Reik et al. 2001). Differences in these epigenetic patterns are important to cellular differentiation and tissue homeostasis. The developmental origins of health and disease hypothesis posits that increased susceptibility to disease after early life experiences is shaped by epigenetic modifications such as DNA methylation and chromatin modifications (Bateson et al. 2004; Gabory et al. 2011). In this issue, Ganu and colleagues (2012) describe diverse approaches for investigating epigenetic marks as a mechanism linking early origins to adult disease in rodent models, nonhuman primates, and humans. Focusing on both in utero constraint (i.e., famine) and overabundance (i.e., high-fat and caloric-dense diets), they review recent and provocative data supporting a role for histone modifications in particular to mediate the effects of early experiences and adult metabolic disease. As an alternative approach, Seelan Angiotensin Acetate and colleagues (2012) focus on a specific time period of vulnerability linked to epigenetic mechanisms. Orofacial clefts occur in approximately 1 to 2 2 of every 100 live births and so are connected with a complex etiology involving both genetic and epigenetic mechanisms. Specifically, they review the literature supporting the hypothesis that the early embryonic palatal methylome, transcriptome, and repertoire of microRNAs act in concert, resulting in normal orofacial ontogeny, which, when deregulated, can lead to secondary palate defects. Nutritional and Environmental Epigenetics Nutri-epigenomics is an emerging discipline examining the role of dietary influences on gene expression. Ultimately, DNA methylation and other epigenetic events, as well as dietary practices, particularly micronutrient intake, may influence disease phenotypes. We’ve previously highlighted the need for an interspecies method of synthesize the prevailing nutri-epigenomic literature to recognize sensitive periods through the entire life training course where diet plan may considerably alter epigenetic marks (Anderson et al. 2012). Today, Niculescu (2012) places forth the intriguing system that, through extensive investigation of varying degrees of nutrient direct exposure during vulnerable period points, experts can grasp the magnitude and amount of impact that each nutrient has on one-carbon metabolism and, subsequently, DNA methylation and other epigenetic events. Focusing on life-course environmental exposures, Ho and colleagues (2012) characterize timing, dose, duration, and chemical composition and important factors leading to epigenetic consequences affecting disease risk. These epigenetic remembrances, once elucidated, can serve as important biomarkers for not only chemical risk assessment and historical exposure but also identification of individuals at risk for future disease. Behavioral and Social Epigenetics Behavioral- and stress-induced epigenetic alterations are widespread from insects to mammals. For example, the desert locust, em Schistocerca gregaria /em , produces more offspring of the gregarious swarming phenotype when breeding in crowded conditions (Maeno and Tanaka 2010), and the pea aphid, em Acyrthosiphon pisum /em , when under stress from crowded conditions or predators, will produce more winged offspring (Weisser et al. 1999), both of which are hypothesized to be linked to epigenetic adaptations. Similarly, rodents exhibit persistent DNA methylation alterations of the glucocorticoid receptor and many other loci in the hippocampus associated with high versus low degrees of maternal grooming in the initial week of lifestyle (McGowan et al. 2011). Herein, Ja?arevi? and co-workers (2012) concentrate on sexually chosen traits, including feminine choice and maleCmale competition, as a simple conceptual framework to greatest assess behavioral epigenetics. They propose an growth to the typically utilized model organisms to fully capture a wider selection of behavioral modification PF-562271 novel inhibtior when it comes to mate choice. Because sexually chosen behaviors are programmed during early embryonic and postnatal development by way of endogenous hormone publicity and because xenobiotic endocrine-disrupting chemicals such as bisphenol A have been shown to impact the fetal epigenome, this provocative approach may help elucidate the origins of steroid-induced epigenetic programming. Also in this problem, Gudsnuk and Champagne (2012) examine animal models of early-life stress and social encounter over the lifespan, concentrating on laboratory rodents and the associations among epigenetic marks and prenatal tension, maternal separation, maternal treatment, abusive caregiving, and public stress. The need for tension in mediating the consequences of early environmental exposures can be discussed. Illnesses of Epigenetic Origins Epigenetic systems in mammals may are suffering from because of totipotency and the necessity to activate genes in mere specific cell types even though all of the cells share the same genetic components (Jablonka and Lamb 2002). Probably the most extensively studied epigenetic phenomena in mammals is normally genomic imprinting, in which one parental allele is definitely epigenetically altered, resulting in parent-of-origin modification of gene transcription (Murphy and Jirtle 2003; Reik and Walter 2001). Irregular developmental expression of imprinted genes results in numerous severe pediatric disorders, such as Prader-Willi syndrome, Angelman syndrome, and Beckwith-Wiedemann syndrome, and is definitely suspected to play a role in many neurological disorders (Murphy and Jirtle 2003). Herein, Skaar and colleagues (2012) review emerging evidence assisting alterations in the epigenome as important contributory or causative roles in human being disease. Focusing on the transition from animal models to human being investigation, they examine several epigenetic mechanisms regulating the imprintome and advocate for the systematic identification of the full human being imprintome using emerging systems. Although several disease phenotypes have been associated with epigenetic etiology, including metabolic syndrome and obesity, neurologic dysfunction and carcinogenesis remain two of the most actively studied diseases of epigenetic origins. In this issue, Schaevitz and Berger-Sweeney (2012) focus on the roles of nutrition and epigenetics in autism and autism spectrum disorders. They focus on the role of one-carbon metabolism and the important cofactors driving this pathway, including methyl donors, such as folate, and vitamins, such as essential B vitamins (e.g., riboflavin). Similar to autism spectrum disorders, cancer is a heterogeneous disease, displaying both genetic and epigenetic etiologies as well as inconsistent methylation profiles; however, in general, the epigenome is widely hypomethylated compared with normal tissue, with notable hypermethylation of tumor suppressor genes (Feinberg 2004). Virani and colleagues (2012) explore animal models of specific pathways of carcinogenesis as essential to understanding mechanisms and discuss the integration of laboratory and epidemiologic methods as a cogent method of greatest translate data to human being clinical and human population methods to better prevent and deal with malignancy. Both Schaevitz and Berger-Sweeney and Virani and co-workers tension that if dietary or environmental elements play a crucial part in altering epigenetic marks and predisposing people to disease, pet models will become invaluable in determining prevention and treatment plans to lessen or get rid of disease. Animal Ethics Factors Linked to Animal Types of Epigenetics The usage of animals is crucial to understanding the mechanisms of epigenetics and central to the problem of the em Journal /em . Animal welfare is forefront in the mind of laboratory workers as they seek to minimize their use while at the same time maximize the irreplaceable epigenetic and other biologic data resulting from their use in research. Harris (2012) provides thoughtful insight into institutional animal care and use committees (IACUCs) perspectives on the use of animal models. Of particular note is the rapid emergence of this field over the last one to two years. Harris clarifies that the powerful epigenome and the countless epigenetic mechanisms that regulate phenotypic expression stand poised to attract the causal blame for most of the illnesses, wellness disparities, and abnormalities today existing in living organisms. Harris targets the function of epigenetic mechanisms in the developmental origins of disease and therefore the ethical factors encircling observing an pet across the whole lifespan. Further, as indicated in this short perspective, several factors donate to epigenetic dysregulation, and IACUCs must make essential decisions about the types of stimuli utilized to induce adjustments to the epigenome. This article should be a useful perspective for not only researchers but also IACUC members. Concluding Thoughts on the Value of Animal Models in Epigenetic Research and the Translation to Human Clinical and Populace Approaches To ultimately succeed in identifying the role of epigenetic mechanisms leading to complex phenotype and disease, researchers must integrate the various animal models, human clinical approaches, and human population approaches, watching the days of sensitivity and model program of evaluation. As highlighted above, it really is more and more known that chemical substance, nutritional, behavioral, cultural, and physical elements alter gene expression and impact health and disease by not only mutating promoter and coding regions of genes but also modifying the epigenome. The use of animal models in these investigations has informed the fields of molecular biology and toxicology by elucidating the mechanisms underlying developmental direct exposure and adult disease. Candidate gene techniques have been recently improved by concomitant entire epigenome technologies. Hence, the evaluation of epigenetic mechanisms in health insurance and disease is currently poised for improved investigation in pet models in addition to expansion into scientific and population wellness approaches. Animal versions will continue steadily to help inform the evaluation of vulnerable schedules and multigenerational research that are not feasible in human being populations. Additionally, the epigenome, in contrast with the genome, is particularly affected by cell-type specificity. Therefore, animal model studies, in which cell type specificity is definitely more readily evaluated than in humans, can serve as important proof-of-principle approaches to evaluate the use of peripheral tissue (e.g., blood, saliva) in human being epigenetic epidemiology studies. Ultimately, to fully flourish in elucidating epigenetic mechanisms underlying disease susceptibility, experts must integrate pet models and individual methods to generate the very best prescriptions for individual wellness evaluation and disease avoidance. Acknowledgments Analysis support was supplied by grants from the National Institutes of Wellness (NIH) (T32 Sera007062 to C. Faulk; ES017524 to D.C. Dolinoy), the University of Michigan NIEHS P30 Core Center (ES017885), and the NIH/Environmental Protection Company (P20 grant Sera018171/RD 83480001). Biography ?? Dana C. Dolinoy, MSc, PhD, may be the John G. Searle Associate Professor of Environmental Wellness Sciences, and Christopher PF-562271 novel inhibtior Faulk, PhD, is normally a study fellow in the Section of Environmental Wellness Sciences, University of Michigan College of Public Wellness, Ann Arbor.. Unlike genetic mutations, these epigenetic adjustments are possibly reversible, offering a distinctive avenue to boost human health. Therefore analysis in epigenetics provides increased dramatically within the last couple of years (Figure 1). Open in another window Figure 1 Literature serp’s show increasing curiosity, albeit at different development prices, in both epigenomics (still left axis) and repetitive elements (correct axis) as time passes. The word epigenetics was popularized in the first 1940s by developmental biologist Conrad Waddington (1940) to describe the interactions of genes with their environment, which provide the phenotype into getting. In the 1970s, Holliday and Pugh (1975) initial proposed covalent chemical substance DNA modifications, which includes methylation of cytosine-guanine (CpG) dinucleotides, as the molecular system to describe Waddington’s hypothesis. The revelations several years afterwards that X inactivation in mammals and genomic imprinting are regulated by complicated and multifactorial mechanisms (Monk 1988; Willard et al. 1993) led to an updated description, describing epigenetics simply because heritable adjustments in gene expression that occur with out a modification in DNA sequence, like the modification of DNA methylation and chromatin redesigning (Wolffe and Matzke 1999). The genomics revolution influenced the investigation of genome-wide instead of regional gene analyses, and the word epigenomics was coined as the analysis of the consequences of chromatin framework like the higher purchase of chromatin folding and attachment to the nuclear matrix, packaging of DNA around nucleosomes, covalent modifications of histone tails (acetylation, methylation, phosphorylation, ubiquitination), and DNA methylation (Murrell et al. 2005). Finally, evidence that demonstrated the resistance of certain gene loci to methylation reprogramming during embryogenesis revealed that epigenetic modifications can be inherited not only mitotically but also transgenerationally (Lane et al. 2003; Morgan et PF-562271 novel inhibtior al. 1999; Rakyan et al. 2003). DNA methylation is the most broadly studied type of epigenetic modification and happens within the one-carbon metabolic process pathway, which depends upon a number of enzymes in the current presence of micronutrient cofactors, which includes folate, choline, and betaine derived through the dietary plan. In mammals, DNA methylation is mainly a well balanced repressive mark bought at cytosines in CpG dinucleotides; nevertheless, its regulation can be more powerful than previously thought (Maunakea et al. 2010). For instance, recent proof for methylation of non-CpG cytosines in human being embryonic stem cells suggests that methylation at non-CpG sites may be important to developmental homeostasis (Lister et al. 2011). It has been documented that CpG dinucleotides are greatly underrepresented in mammalian genomes because of spontaneous deamination of 5-methylcytosine to thymine and subsequent fixation in a population over evolutionary timescales (Holliday and Grigg 1993). Thus, the majority of unmethylated CpG sites occur within CpG islands, defined as discreet regions containing a preponderance of CpG content (Deaton and Bird 2011). The resulting uneven distribution of CpG islands is thought to result from uniform genomic CpG site deamination and conversion coupled with the regeneration of new CpG islands within repetitive components with growth by retrotransposition (Xing et al. 2004). Normally, CpG islands can be found within or near gene promoters or in the 1st exons of housekeeping genes. On the other hand, your body and regulatory components of repetitive DNA sequences, such as for example transposable components, are methylated, as a result inhibiting the parasitic transposable and repetitive components from replicating by transcription. Of essential note, nevertheless, not absolutely all animals make use of DNA methylation as a gene repression system; for instance, the model organisms fruit fly ( em Drosophila melanogaster /em ) and roundworm ( em Caenorhabditis elegans /em ) absence appreciable DNA methylation, whereas other bugs and nematodes perform keep DNA methylation machinery (Gutierrez and Sommer 2004; Maleszka 2008). Epigenetic manipulation of cellular phenotype can be powered by alteration of chromatin framework by covalent histone adjustments and incorporation of histone variants in to the nucleosome (Saha et al. 2006). Chromatin is certainly a nucleoprotein complicated that deals linear genomic DNA through a range of nucleosomes. Each nucleosome includes about 147 bottom pairs of DNA coiled around an octamer of histone proteins. Each octamer includes two copies each one of the four primary histones, H2A, H2B, H3, and H4. Chromatin may be further modified by association with linker histones, histone variants, and nonhistone proteins as well as myriad posttranslational modifications of histone proteins, including histone acetylation, methylation, ubiquitination, phosphorylation, and ADP-ribosylation (Caiafa and Zampieri 2005; Cheung and Lau 2005). Histone acetylation is usually associated with transcriptional activation because the affinity of histone proteins for DNA is usually reduced and chromatin packaging is relaxed. Histone methylation results in various transcriptional consequences PF-562271 novel inhibtior depending on histone.

domain: medical


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Transdev launching autonomous school shuttle at Florida's Babcock Ranch
This fall, Transdev will debut the first autonomous school shuttle in the world at Babcock Ranch—the first fully solar-powered community in the country—in Florida.
Transdev, which is the mobility partner for Babcock Ranch, is completing more than two months of testing on school shuttle routes that will augment existing autonomous options within the community.
During the pilot-program, Transdev will offer the service to Babcock Neighborhood School (BNS) students who live within Babcock Ranch. Transdev will use the pilot to evaluate rider behavior and demand.
“Not only are we providing an important mobility option for these children, but what an opportunity for them to see the amazing power of science, technology, engineering and math that help this shuttle run safely and efficiently,” says Dick Alexander, Executive Vice President of Business Development and Innovation at Transdev.
“The whole experience is something we hope they will never forget.”
BNS students living within Babcock Ranch will have the distinction of being the first in the U.S. to catch a ride to school on an autonomous shuttle. By January, nearly 30 of the 316 students enrolled in grades K-7 at BNS this year will be living within the new solar-powered town located just northeast of Fort Myers, Florida.
A 12-person Easy Mile EZ10 Gen II shuttle will be used to transport students during the pilot. Capable of reaching a standard cruising speed of eight miles per hour and braking automatically and swiftly when obstacles are detected, the vehicle will have a safety attendant on board at all times when students are riding to make sure that they are comfortable, and to answer any questions that they might have about the technology.
Before the pilot officially begins, students and families will have the opportunity to ride the shuttle.
“It makes me wish I were a kid again,” says Syd Kitson, CEO of Kitson & Partners, the developers behind Babcock Ranch.
“This is definitely a sign of progress and a sincere testament to a shared commitment to sustainable living. For many of the kids moving in and living here, autonomous school shuttles will be the only school transit they ever know. I’m definitely jealous of them and so proud of this concept.”
During the pilot, the shuttle will remain an option for students who live farther from the school, as well as on days when there is foul weather. Eventually, students and parents will be able to book on-demand, door-to-door school shuttles based on individual needs.

domain: news


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For businesses seeking recognition as separate legal entities, North Carolina law allows them to undergo the process of incorporation. As a separate entity from the owners, the business is then considered to be operating on its own when it buys and sells property, assents to contracts and exercises legal rights. To incorporate in North Carolina, a business must file with the Secretary of State in compliance with particular guidelines.
Benefits of Incorporation in North Carolina
Advantages of incorporation are many. The primary benefit is that the liabilities of the business can only be satisfied by the assets specifically invested into the company by the owners. If the business had remained a personal asset of the owners, they would run the risk of losing their personal property to pay for the company's financial liabilities in case of default. Furthermore, banks in the Southern Pines area prefer to evaluate the credit worthiness of a business as a whole rather than that of individual owners. This makes the process of obtaining corporate loans simpler. Finally, the ownership of a corporation is divided into an abundance of equal portions or "shares" of stock. Without this mechanism, transferring ownership of a business would be impractical.
Costs of Incorporation
Along with a possible fee to file for incorporation in North Carolina, there are other costs that corporations incur. The most important is that a corporation is taxed as its own entity. In other words, the profits a corporation makes are now taxed separately, while any disbursements to shareholders are taxed as individual income. This is called double taxation. However, a business may avoid this disadvantage with proper planning and assistance from a local Southern Pines lawyer.

domain: law


Violin vibrato, what a mystery it is! I was always afraid to post a video on vibrato because I was always self-conscious about it. In the last installment of Violin Basics with Eric, we talk about vibrato, the different kinds of vibrato, and how to use the previous videos to help get the sound you want.
Before watching this video, review the other videos in the "Violin Basics with Eric" Series:
How to place the finger on the violin string - https://youtu.be/XB86o6ETXiA
Violin Finger Weight - How do you press your finger on the violin string? https://youtu.be/eBSX_cpGpG0


We can reveal the names of two keynote speakers now, with more to be announced. They are:
Joseba Zulaika The Director of the Centre for Basque Studies at the University of Nevada in Reno and an anthropologist by training. Among his research interests are the international discourse of terrorism. His 2009 book Terrorism: the Self-Fulfilling Prophecy was published by the University of Chicago Press. His recent explorations of terrorism focus in particular on the role of intellectuals and reflect on the domain of terrorism studies. This self-reflexive focus – which is comparatively rare in academic work on terrorism – is the reason why we particularly wanted Prof Zulaika to deliver a keynote at the conference.
Michael Stohl is Professor of Communication at the University of California Santa Barbara. Stohl’s research focuses on organizational and political communication with special reference to terrorism, human rights and global relations. Stohl’s focus on Terrorism as communicatively constituted violence and his current work on terrorism networks and counter terrorism are the key reasons why he is being invited to deliver a keynote. He will also lead a masterclass workshop at the conference.
More information to come very soon….
David Miller, Chair of the Organising Committee
davidmiller AT strath.ac.uk


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https://deportevida.com/fzajg9dn Ushering this Chinese New Year, Sunway Putra Hotel will be offering an extravagant buffet dinner for its diners on 24th January 2010 from 6:30pm to 10:00pm at its level 10’s restaurant.
Diners may starts its exquisite meal with an array of appetising starters such as Chilli Mayo Crabmeat & Grilled Corn Salad, Chicken Salad with Asian Dressing in Octopus Salad, Seafood such as Oyster, Green Mussels and Tiger Prawns on Ice; served with Lemon Wedges and Tabasco Sauce and many more delicious appetizers.https://condiodo.com/blog/z38tjnsy
Buying Tramadol Online Reviews Tantalize your taste buds with traditional Chinese cuisine embodied in Chef’s must-try dishes such as Chinese Black Pepper Beef, Steamed Fish with Superior Soya Sauce, Wok Fried Prawn with Spicy Special Sauce, Sea Cucumber and Mushroom Stew on Brassica and many others.
https://www.how-matters.org/2023/04/19/3unjzroaz The buffet is priced at RM 108 nett per person and half price for senior citizens and children aged 7-12 years old. For those who purchase Early Bird Vouchers which are available from now till 10th January 2020, the buffet is charged at RM 88 nett per person.
https://www.innova-pain.com/2023/04/19/76i9k1u4fr For more information or reservations, call 03 4040 9888 ext; 9038 or email [email protected]Purchase Tramadol Overnight Cheap

domain: food


State-owned buildings must be designed, constructed and certified to exceed by 30% the energy efficiency requirements of ASHRAE 90, 1-2004 for new buildings. New buildings have existed on average for more than 100 years, so the buildings being built today guarantee a particular energy trajectory in the future. Therefore, strong policies are required, in collaboration with the county and the state, to achieve an almost carbon-neutral park of buildings. The first passive house was built in 1991 in Darmstadt, Germany.
More than 40,000 buildings have been built in the following years, and Passive House has become the most tested and most rigorously verified performance-based construction standard. The passive house uses on average 90% less energy than conventional construction. With such large energy savings, it is much easier to reach a building with zero net emissions, prepared for zero net emissions or with positive net values. Design for a passive house near Asheville, North Carolina.
The existing non-residential building stock requires modernization in the same way as the existing housing stock. Buildings purchased by the State must comply with any state laws or local ordinances that were in effect during their construction. Even so, there's no reason why the state's developers can't build significantly more energy efficient homes, said Cheslak, of the New Building Institute. To achieve a fleet of buildings with almost zero carbon emissions by 2050, it is necessary to interrupt the installation of gas boilers and their replacements as soon as possible.
Last month, the state's building codes council adopted the new rule, which allows developers to circumvent some energy conservation requirements if they follow a voluntary set of green building regulations. Whatever their motivations, developers have hindered efforts in recent years to strengthen the model energy code for North America and its adoption by localities across the country. However, it highlights the role that developers are playing across the country in stopping efforts to improve the energy efficiency of buildings, just as climate scientists say we should do the opposite. They are the biggest consumers of energy and, therefore, are the biggest component of emissions in Charlotte.
On June 11, 1996, the Building Code Council adopted the CABO Single Family and Two-Family Housing Code of 1995, with amendments from North Carolina that would take effect on July 1, 1997. But they would require Republican-led General Assembly legislation and, almost certainly, the support of the North Carolina Home Builders Association, which has eluded energy conservation advocates for at least a decade. There are standards, but to achieve the objective, a design is required that allows energy development with zero net emissions by 2030. They require a considerable amount of work and effort with a diverse property, including landlords, mixed-use developments, and multi-family homes.
According to the North Carolina nonprofit Building Performance Association, about 30% of new homes in the state obtain a certified energy rating index every year. Ryan Miller, who heads the North Carolina Building Performance Association, says it draws on state-specific inputs to produce a specific index number for each state. An underground bunker would work very well in terms of energy efficiency; not many users consider this to be an acceptable environment for human beings to live in. And it exposes how inadequate North Carolina's energy conservation code is in light of its own climate objectives.


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The PML-N will not become part of any “undemocratic act” to remove Prime Minister Imran Khan from office, PML-N leader and former prime minister Shahid Khaqan Abbasi said Monday.
“This is our firm decision. We will not be used to remove anyone,” Abbasi told SAMAA TV in an interview. The senior vice president of the PML-N, however, clarified that his party does want to oust PM Khan’s government but by using constitutional options.
“We will force the government to take the vote of confidence,” Abbasi explained his party’s strategy. He said that the government will itself learn that the time has come for them to go home when they will see their coalition partners parting ways.
The PML-N, the largest opposition party in the National Assembly, has a murky past. The PML-N and the PPP, the second largest opposition party, have been used against each other by the country’s establishment previously to disrupt the democratic system.
The PML-N was once considered a pro-establishment party but it changed its path after former prime minister Nawaz Sharif was removed from office following a verdict of the Supreme Court in the Panama Leaks case in 2017. Nawaz was jailed in another corruption case, but later allowed to leave Pakistan to receive medical treatment in London.
The party blamed the country’s establishment for the party’s downfall and its election loss. Abbasi, the PML-N leader, said that what happened in the 2018 elections proved that his party wasn’t liked by the establishment.
“The establishment does exist in Pakistan as it exists all over the world,” the PML-N leader said. “They have their own stance and if there is no similarity between your stance and theirs then problems arise.”
“If you want to say that there is an establishment, it is certainly here. Does it interfere in the affairs? It certainly does,” Abbasi said.
However, he clarified that the PML-N doesn’t want a fight with the establishment but warned that it doesn’t want to be used by anyone.
The statements of the PML-N leaders before and after the 2018 elections had revealed that there was a trust deficit between the party and the establishment. Weeks before the elections, Nawaz even accused a powerful army official of attempting to change loyalties of his party candidates.
But when the country’s apex court blocked PM Khan’s move to grant a three-year extension to Army Chief General Qamar Javed Bajwa, the PML-N and other opposition parties sided with the government and helped it pass a bill that paved the way for the extension in the general’s tenure.
Abbasi, the PML-N leader, was in jail when the voting on the bill took place. He said he would have voted in favour of the bill if he wasn’t in jail.
“In the parliamentary system, your vote is not yours but the party’s,” said Abbasi. “If the party has taken a decision then that is my decision too whether I like it or not it’s a separate thing.”
But there were other lawmakers in the opposition parties that choose to defy the decision of their parties and didn’t vote in favour of the bill. Senator Pervaiz Rasheed of the PML-N was one of them.
Abbasi said that Rasheed didn’t have any right to go against the party’s decision. “I am ready to say it on his face that he doesn’t have the right to do so.”
“If he didn’t want to vote then he should have resigned,” the PML-N leader said.
Source Link: Won’t support any ‘undemocratic act’ to remove PM Khan: Abbasi


ZOMBIELAND: DOUBLE TAP Bloopers + BHS (2019)
- Published on Oct 19, 2019
- Check out the official bloopers and Behind the Scenes for Zombieland: Double Tap starring Woody Harrelson! Let us know what you think in the comments below.
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Directed by: Ruben Fleischer
Cast: Woody Harrelson, Jesse Eisenberg, Emma Stone, Abigail Breslin, Rosario Dawson, Zoey Deutch, Luke Wilson
in theaters October 18
In the sequel, through comic mayhem that stretches from the White House and through the heartland, these four slayers must face off against the many new kinds of zombies that have evolved since the first movie, as well as some new human survivors. But most of all, they have to face the growing pains of their own snarky, makeshift family.
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- Film & Animation


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PUMA Kills Stem Cells to Stall Cancer?
Apoptosis evasion is a hallmark of human cancer. PUMA is a BH3-only Bcl-2 family protein that mediates both p53-dependent and independent apoptosis. However, its role in tumor suppression had not been well established. Our recent work provides direct evidence that PUMA plays an important role in suppressing intestinal tumorigenesis in two mouse models including (i) the azoxymethane (AOM)/dextran sulfate sodium salt (DSS)-treated mice and (ii) APCMin/+ mice. The activities of PUMA appeared to be in the intestinal stem cells, and involve both p53-dependent response to DNA damage, and p53-independent mechanisms triggered by inflammation. Our data suggest that the interplay between different apoptotic pathways in intestinal stem cells underlie the initiation of intestinal carcinogenesis, and should be considered in the context of cancer prevention and therapy.
Full Text: PDF
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Copyright © 2008 LumiText Publishing. All rights reserved.


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Riad Moullouad was, in my opinion, the perfect place in which to pop my Moroccan cherry.
With a late flight into the city airport the Riad arranged a no hassle transfer which was ready and waiting to whisk our bags and ourselves the 20 minute drive into the city.
Throughout our stay the guys in the Riad were nothing but friendly and helpful. No matter what our query was, it was never any bother or hassle for them. Always extending the warm Moroccan welcome, taking an interest in our days activities and sharing their infinite wisdom to help us plan the next days adventures.
Location-wise the Riad is located a slightly confusing(first time) but easily memorable ten minute walk into the Main Square.
- Official Description (provided by the hotel):
- This Riad is located in central Marrakesh, in the Medina and a 10-minute walk to Jamaa El Fna Square. It has 3 swimming pools, a hammam and a panoramic roof terrace. Each of the Riad De Charme's guest rooms has a private bathroom and free Wi-Fi internet access. The Moullaoud's restaurant serves traditional, regional cuisine which can be enjoyed on the hotel terrace and patio. Guests of the Riad De Charme can enjoy massage treatment and relax in the Hammam or on the sunbathing terrace. Golf is available nearby. Riad De Charme Moullaoud is just a 2-minute walk from old markets, souks and guests can visit the nearby Ben Youssef Medersa, and Jemaa El Fna square. ... more less
- Reservation Options:
- TripAdvisor is proud to partner with Expedia, Booking.com, Hotels.com, Orbitz, Travelocity, Cancelon, Hotwire, TripOnline SA, Cheap Tickets and Evoline ltd so you can book your Riad Moullaoud reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.
- Also Known As:
- Riad Moullaoud Hotel Marrakech

domain: travel