|Publication number||US7865644 B2|
|Application number||US 11/927,911|
|Publication date||Jan 4, 2011|
|Filing date||Oct 30, 2007|
|Priority date||Oct 30, 2007|
|Also published as||US20090113097|
|Publication number||11927911, 927911, US 7865644 B2, US 7865644B2, US-B2-7865644, US7865644 B2, US7865644B2|
|Inventors||Bernard Charles Drerup, Richard Nicholas, Prasanna Srinivasan|
|Original Assignee||International Business Machines Corporation|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (15), Classifications (5), Legal Events (5)|
|External Links: USPTO, USPTO Assignment, Espacenet|
1. Field of the Invention
The invention disclosed and claimed herein generally pertains to a method and apparatus for improving performance of a configuration comprising a bus controller and master and slave devices connected thereto. More particularly, the invention pertains to a method and apparatus of the above type, wherein multiple slave devices are simultaneously connected to a single interface of the controller, and command to command pipelining is used with at least one of the multiple slave devices. Even more particularly, the invention pertains to a method and apparatus of the above type, wherein specified mechanisms are added to the bus controller and also to the master and slave devices, in order to achieve the above goals.
2. Description of the Related Art
As is known by those of skill in the art, buses are used in applications such as system-on-a-chip, as well as other applications, to interconnect a variety of devices such as processors, memories, and I/O devices. These buses have bus controllers, which are used to interconnect active devices that include both master and slave devices, so that the active devices can communicate with one another. Some types of bus controllers have one or more interfaces for master devices, and also have one or more other interfaces for the slave devices. Each interface comprises a dedicated set of pins or wires, which can be attached to either a master or a slave device depending on the type of interface. In some typical arrangements, a bus controller has eight or twelve dedicated master interfaces, and can thus support eight or twelve master devices, respectively.
Commands to transfer data, also known as requests, originate within a master device, are sent to one or more slave devices, and are then acknowledged or responded to by the slave devices. A command typically includes the address of the intended slave recipient, the length of the transaction and whether the transaction is a read or write request. Generally, a read request causes data to be read from a slave to the master, and a write request causes data to be written to a slave from the master. Slaves generally acknowledge the commands with either an acceptance, a retry, or an error message. As used herein, an acceptance indicates that the slave recipient of a command is able to comply and will do so. A retry indicates that the slave is not able to carry out the request at the time that the command is received, so that the command should be retried or re-sent later.
It is often desirable to allow multiple slaves to be attached to a common, or the same, slave interface of a bus controller. Most signals sent from the bus controller to the slave devices, such as address and write data, are then multi-dropped. That is, the signals are broadcast to all slaves connected to the common interface, even though only one slave will respond to the signals. Similarly, most signals from multiple slaves attached to a common interface are grouped together in an OR arrangement. That is, they are all connected to the controller interface through a common read data bus. Data is read from only one slave device at any one time, while the other slaves remain inactive. Thus, the output of the read data bus is determined only by the input provided by the active slave, similar to the operation of an OR gate.
An important advantage in attaching multiple slaves to a single slave interface is that the bus controller can support a large number of slaves, without requiring extensive resources in terms of bus controller area and power. In one configuration, performance is managed by arranging high performance slaves to each use a unique, individual interface to the bus controller, while arranging the lower performance slaves to share a common interface. Notwithstanding the advantages of this configuration, however, prior art bus controllers that attach multiple slave devices to a single slave interface generally cannot support command to command pipelining. Herein, a command is initiated when it is sent from a master device to one of the slave devices. A command is completed when a response acknowledging the command has been received back by the master device. As used herein, the terms “pipelining”, “command pipelining” and “command to command pipelining” all refer to a procedure wherein a master device is allowed to initiate or send out a command before a response acknowledging a previously initiated command (and which completes the previous command) has been delivered back to the sender. Command pipelining clearly improves performance, by reducing time requirements in comparison with systems that must wait for a command to be acknowledged before the next command can be sent. Thus, it would be desirable to support command pipelining in a bus controller and its connected devices, while at the same time supporting connection of multiple slaves to a single slave interface.
In accordance with the invention, a set of mechanisms are selectively added to a bus controller, and to slave devices connected to the bus controller. A mechanism is also added to one or more master devices connected to the bus controller, in order to provide the master devices with a transaction ordering capability. The added mechanisms collectively achieve the objectives stated above, that is, supporting connection of multiple slave devices to a common controller interface, and at the same time allowing pipelined operation of the slave devices. One embodiment of the invention is directed to a method for use with a bus and an associated bus controller, wherein the bus controller has respective master and slave interfaces for use in selectively interconnecting master devices and slave devices. The method comprises the steps of connecting one or more of the master devices to one of the master interfaces, and connecting each of a plurality of slave devices to the same one of the slave interfaces. The method further comprises operating a connected master device to send multiple commands to selected connected slave devices in accordance with a command pipelining procedure.
The novel features believed characteristic of the invention are set forth in the appended claims. The invention itself, however, as well as a preferred mode of use, further objectives and advantages thereof, will best be understood by reference to the following detailed description of an illustrative embodiment when read in conjunction with the accompanying drawings, wherein:
In the configuration of
In the transfer of data, data is generally written from a master device into one or more slave devices. Also, data is generally read from one or more slave devices to a master device. As described hereinafter in further detail, bus controller 110 and at least some of the devices 102-108 and slave devices 112-122 are respectively adapted to carry out command pipelining operations, as defined above, in accordance with an embodiment of the invention.
Similarly, a read data bus 206, which is also 128 bits, receives read data signals from each of the slave devices 112 and 114. These signals are handled in accordance with an OR procedure, as represented by gate 210. That is, controller 110 allows only one slave device at a time to be active and to send its signals to the controller. During such time, all other slave devices connected to the slave interface remain inactive, and only drive 0's. Thus, only the active device can effectively send its signal values past the OR gate.
In accordance with embodiments of the invention, a number of mechanisms are respectively added to the bus controller and to the slave and master devices. Usefully, these mechanisms comprise the following:
Mechanism (1) Each of the slaves 112-114 must respond to a command, at a fixed number of clock cycles after receiving the command. This ensures that each response is uniquely mapped to its command, or request, even when multiple commands are sent before the response is received. Possible responses include acknowledgements such as acceptance, retry, ability to intervene, and shared ownership of a cache line. Also, only one command or request can be sent during a clock cycle. This capability is represented as a mechanism (1), shown in
Mechanism (2) A further mechanism 216 (or mechanism (2)) is added to each slave, so that a response to a command by a slave includes a decode signal that is unique for the slave. The decode signals allow bus controller 110 to determine how many slaves responded to a particular command. Most commands require exactly one slave to respond. Thus, an error can be readily detected by the bus controller if the required response is not received, such as if two or more decode signals are received, or no decode signals are received. The decode signals are also used to uniquely identify their corresponding slaves, as described hereinafter.
Mechanism (4) Master devices must control the order of successive transactions, while allowing multiple commands to be pending and allowing commands to be retried. To achieve this, at least some of the masters, such as master device 102 shown in
In some configurations, an intermediate slave device, such as a bridge, is located between two buses. In such configuration, a command or request can be “posted”, or internally stored by the intermediate slave for some period of time. Accordingly, a request may not have reached its final destination when a command response of acknowledgement is sent to the master. Once a request is “posted”, if a device beyond the bridge (such as the final destination slave) retries the request, it is the responsibility of the bridge to repeat the request, and the master is never informed of the activity beyond the bridge (between the bridge and the final destination). “Posting” of requests assumes that there is no signal from the final destination to the master to indicate completion (such as a “write complete”). Since a bridge that posts a request provides an acknowledgement to the master before the request has reached its final destination, the master may request a held command before the posted command has reached its final destination. To ensure ordering requirements of the master device are met, the bridge must either keep transactions in order all the time, or else keep transactions in order when the master indicates that the order must be maintained. (As an example, a bus transaction known as Sync is a transaction that indicates this ordering requirement.
Mechanism (5) Referring further to
Mechanism (6) Bus controller 110 is provided with a mechanism 222 (or mechanism (6)) that keeps track of each unique decode signal asserted by a slave or slaves, when responding to a write command from a master device. Then, after receiving a wr_data_request from the master, the bus controller asserts a unique wr_data_start only to the slave(s) that asserted the code signal during the command phase. Slaves only accept a write data packet associated with the assertion of wr_data_start. This ensures that a write data packet is received only by the intended slave or slaves. Writes that are broadcast to multiple slaves cause multiple decode signals to assert, and consequently cause multiple wr_data_start signals to assert.
Lines 302 and 304 of
Referring further to
After receiving the write command acknowledgement from slave device 0 b, master device 102 asserts a request wr_data_rq to bus controller 110, as shown by line 308, to write data to slave 0 b. A wr_data_grant signal is then asserted to master device 102 by the bus controller, at line 310, whereupon the master device writes data 344 comprising data elements b1-b4, as shown by lines 310 and 336. For the write data operation, lines 338 and 340 in
Referring further to
An operating system runs on processor 402 and is used to coordinate and provide control of various components within data processing system 400 shown in
The invention can take the form of an entirely hardware embodiment, an entirely software embodiment or an embodiment containing both hardware and software elements. In a preferred embodiment, the invention is implemented in software, which includes but is not limited to firmware, resident software, microcode, etc.
Furthermore, the invention can take the form of a computer program product accessible from a computer-usable or computer-readable medium providing program code for use by or in connection with a computer or any instruction execution system. For the purposes of this description, a computer-usable or computer readable medium can be any tangible apparatus that can contain, store, communicate, propagate, or transport the program for use by or in connection with the instruction execution system, apparatus, or device.
The medium can be an electronic, magnetic, optical, electromagnetic, infrared, or semiconductor system (or apparatus or device). Examples of a computer-readable medium include a semiconductor or solid state memory, magnetic tape, a removable computer diskette, a random access memory (RAM), a read-only memory (ROM), a rigid magnetic disk and an optical disk. Current examples of optical disks include compact disk-read only memory (CD-ROM), compact disk-read/write (CD-R/W) and DVD.
Further, a computer storage medium may contain or store a computer readable program code such that when the computer readable program code is executed on a computer, the execution of this computer readable program code causes the computer to transmit another computer readable program code over a communications link.
A data processing system suitable for storing and/or executing program code will include at least one processor coupled directly or indirectly to memory elements through a system bus. The memory elements can include local memory employed during actual execution of the program code, bulk storage, and cache memories which provide temporary storage of at least some program code in order to reduce the number of times code must be retrieved from bulk storage during execution.
Input/output or I/O devices (including but not limited to keyboards, displays, pointing devices, etc.) can be coupled to the system either directly or through intervening I/O controllers.
Network adapters may also be coupled to the system to enable the data processing system to become coupled to other data processing systems or remote printers or storage devices through intervening private or public networks. Modems, cable modem and Ethernet cards are just a few of the currently available types of network adapters.
The description of the present invention has been presented for purposes of illustration and description, and is not intended to be exhaustive or limited to the invention in the form disclosed. Many modifications and variations will be apparent to those of ordinary skill in the art. The embodiment was chosen and described in order to best explain the principles of the invention, the practical application, and to enable others of ordinary skill in the art to understand the invention for various embodiments with various modifications as are suited to the particular use contemplated.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US5684977 *||Mar 31, 1995||Nov 4, 1997||Sun Microsystems, Inc.||Writeback cancellation processing system for use in a packet switched cache coherent multiprocessor system|
|US6081860 *||Nov 20, 1997||Jun 27, 2000||International Business Machines Corporation||Address pipelining for data transfers|
|US6115763 *||Mar 5, 1998||Sep 5, 2000||International Business Machines Corporation||Multi-core chip providing external core access with regular operation function interface and predetermined service operation services interface comprising core interface units and masters interface unit|
|US6195716||Jun 11, 1998||Feb 27, 2001||Bull Hn Information Systems Italia S.P.A.||System bus interface controlling at least one slave device by exchanging three control signals|
|US6298066||Apr 14, 1999||Oct 2, 2001||Maxim Integrated Products, Inc.||Single wire bus interface for multidrop applications|
|US6587905 *||Jun 29, 2000||Jul 1, 2003||International Business Machines Corporation||Dynamic data bus allocation|
|US6970962 *||May 19, 2003||Nov 29, 2005||International Business Machines Corporation||Transfer request pipeline throttling|
|US20030101400 *||Nov 27, 2002||May 29, 2003||Kenichiro Anjo||Bus system and retry method|
|US20060090024 *||Oct 24, 2005||Apr 27, 2006||Yuzuru Tanabe||Bus controller|
|US20070130410 *||Nov 17, 2005||Jun 7, 2007||P.A. Semi, Inc.||Retry mechanism|
|US20070255886 *||Jun 14, 2006||Nov 1, 2007||Xilinx, Inc.||Programmable logic device including programmable interface core and central processing unit|
|US20080082707 *||Sep 28, 2007||Apr 3, 2008||Synfora, Inc.||Non-blocking bus controller for a pipelined, variable latency, hierarchical bus with point-to-point first-in first-out ordering|
|JPH01241237A||Title not available|
|JPH04100341A||Title not available|
|JPH10222461A||Title not available|
|U.S. Classification||710/110, 710/306|
|Oct 30, 2007||AS||Assignment|
Owner name: INTERNATIONAL BUSINESS MACHINES CORPORATION, NEW Y
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:DRERUP, BERNARD CHARLES;NICHOLAS, RICHARD;SRINIVASAN, PRASANNA;REEL/FRAME:020037/0624;SIGNING DATES FROM 20071023 TO 20071030
Owner name: INTERNATIONAL BUSINESS MACHINES CORPORATION, NEW Y
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:DRERUP, BERNARD CHARLES;NICHOLAS, RICHARD;SRINIVASAN, PRASANNA;SIGNING DATES FROM 20071023 TO 20071030;REEL/FRAME:020037/0624
|Aug 15, 2014||REMI||Maintenance fee reminder mailed|
|Dec 30, 2014||FPAY||Fee payment|
Year of fee payment: 4
|Dec 30, 2014||SULP||Surcharge for late payment|
|Mar 13, 2015||AS||Assignment|
Owner name: LINKEDIN CORPORATION, CALIFORNIA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:INTERNATIONAL BUSINESS MACHINES CORPORATION;REEL/FRAME:035201/0479
Effective date: 20140331


text:
First I wanted to say that I enjoy JRR Tolkien's works and the movies that have come out recently. So too I have found the works of Peter Kreeft, Michael Coren and Joseph Pierce to be extremely helpful in bringing to light the Cathlicity of his books. For such things I am extremely grateful and would encourage other's to take such things in consideration before or after viewing the conference.
Now, having said that, I do think that the priest that gave this conference did a genuinely great service to the church in exposing some of the problematic aspects of Tolkien's literature. I, along with New Catholic at Rorate-Caeli, disagreed with the talk, but I do believe that he made some interesting points that should be taken into account and not brushed aside as Rad Trad reactionary non sense which you might guess the normalist who himself over reacted and trashed the priest... need i really say his name, I think it suffices to say he didn't listen to the talk, but went mad that anyone would question the efforts to over emphasis the Cathlicity of Tolkien's work.
I also found it interesting, seeing from the reactions to the post and those on Rorate's twitter, that people are defending Tolkien's work as if it were sacrosanct.
Seriously, there are good things to Tolkien's books and they should be applauded, but for crying out loud dont defend what Tolkien didn't attempt to put forth. There are issues with the books and with Tolkien's attitude towards allegory which go unquestioned until this talk shook up the preconceived notions that all Tolkien is orthodox and therefore unquestionable.
Please listen to the talks, take them into account and make your own decision. The goal of the talks was not to condemn Tolkien, but to bring balance to the current discourse.
Have a great weekend!
|What say You?|
+Pray for Francis P.P.+

domain: literature


text:
The black-and-white vintage photos show Mexican American students buying and selling World War II stamps and young Chicana women in sailor dresses sitting together for a 1942 class picture.
They’re part of a collection compiled by Roberto “Tex” Murillo, a hobbyist and self-taught historian who for decades has gathered artifacts and photos of Riverside’s Casa Blanca neighborhood – one of Southern California’s classic Mexican American barrios established in the late 1800s.
“All these people in these photos, that’s the heart of Casa Blanca,” said Murillo, who has lived in the neighborhood for decades.
Dubbed “Tesoros de Casa Blanca,” or “Treasures of Casa Blanca,” Murillo’s photos are being used as a way to preserve the history of Riverside’s Latino community.
The collection has initiated ethnic studies discussions with Riverside Unified School District board members about documenting Casa Blanca and other predominantly Latino Riverside neighborhoods, such as the Eastside, in history books. A series of community events showcasing the photos has been planned. One occurred earlier this month; another exhibit is scheduled for December.
To Riverside resident Mary Pasillas, who is helping organize events featuring Murillo’s collection, the photos tell a more nuanced story of Casa Blanca, a neighborhood that some believe has an undeserved reputation for crime that is based more on perception and memories of gang problems in the 1970s and 1980s.
“Each community has its tesoros,” Pasillas said. “There’s this other story of Casa Blanca.”
Casa Blanca, which means “white house” in Spanish, is named after an adobe home built in the 1870s.
The neighborhood housed workers who picked oranges in groves that spread to the south and west of Casa Blanca. The workers were mostly Mexican, but some were Japanese, Chinese or Italian.
Many residents who did not work in the groves labored in packinghouses.
The archives offer a counternarrative to a long history of anti-Mexican sentiment, said Steven Moreno-Terrill, a public history graduate student at UC Riverside.
Moreno-Terrill, whose research focuses on the history of Mexican American education in the Inland Empire, said the photographs also are a response to a history of record-keeping that often “privileges and centers the stories of white communities.”
“You can’t tell Riverside’s story without the stories of communities of color,” he added. “What makes this type of work different is that it is community-generated.”
Around the neighborhood, Murillo is known as “Tex the Art Historian.” He keeps class pictures and other photos stored in binders, arranged alphabetically and by grade level.
If you find a photo of your grandfather in your garage, you give it to Murillo for his collection. Or, if you want to see a photo of your grandmother who graduated in 1939, you go to Tex.
Of particular importance to Murillo’s archives is the segregated Casa Blanca School, which had black and Asian students in addition to Latinos. It often received hand-me-down textbooks. The school eventually closed during desegregation in 1965.
The school remains a source of pride for the community, and Murillo’s collection embodies that with numerous class photos.
The portraits are what Moreno-Terrill referred to as an institutional memory of the segregated community school. Every class was routinely photographed throughout the years, and generations of Casa Blanca students were recorded in that way.
“This was one of the few official archival practices that was practiced in the Mexican American community by the city,” Moreno-Terrill said.
“They are a visual link to the community’s past where people can identify their family members or themselves as part of Riverside’s history,” Moreno-Terrill added.
Murillo and others often recall how a group of women petitioned to build a school for the children of the neighborhood, who at the time were taught in a warehouse. After that, the Casa Blanca School was built.
“Can you imagine the courage those ladies had?” Murillo said. “You’re talking about 1911, this when you would find signs in Riverside saying, ‘No Mexicans Allowed.’
“It was a very tough period,” he added. “Those are heroes to me.”
Contact the writer: 951-368-9462, firstname.lastname@example.org, or on Twitter @alemolina

domain: news


text:
Dr. Gary Miyasaki is a licensed audiologist with a degree in Audiology. Dr. Miyasaki is knowledgeable in the latest hearing aid technology so he can help you choose the solution works best for your hearing needs.
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domain: medical


text:
Alexandria Ocasio-Cortez Blasts Trump's Speech, Suggests Illegal Immigrants Acting 'More American' Than Him
U.S.-bound immigrants are acting more in the American spirit than President Trump.????Those are the thoughts of Representative Alexandria Ocasio-Cortez when speaking to MSNBC following President Trump’s address on immigration????The New York Democrat slammed President Trump’s immigration policies, saying that the legal immigration process is being restricted to the point where more people are forced to become undocumented and then “he’s trying to attack their undocumented status”.????Ocasio-Cortez continued when speaking to MSNBC’s Rachel Maddow????(Ocasio-Cortez SOT)??“It is anti-American.
And again, those women and children trying to come here with nothing but the shirts on their back to create an opportunity and to provide for this nation are acting more in an American tradition than this president is right now.”????The freshman lawmaker called Trump’s border wall command a “campaign fantasy”, saying that he has “decided to hold the paychecks of everyday Americans hostage” to fulfill it.????Ocasio-Cortez tweeted a story of a furloughed Department of Housing and Urban Development worker she met.????According to her the worker said “please don’t give into a wall.
I don’t want the political tool of withholding my paycheck to be legitimized.”????Ocasio-Cortez has stayed silent on whether she will be taking a paycheck during the partial government shutdown despite her call for members of Congress to “have some integrity” and work without pay during the period.
Democratic Representative Alexandria Ocasio-Cortez on Wednesday said it's not "a game" for migrants fleeing "horrifying" situations and defended her decision to dismiss the Senate's aid measure, saying..


The duo were there to promote their upcoming new album Walk The Sky which will be released on October 18 through Napalm Records.
While in the studio, the pair played a two song acoustic set showcasing their tracks In Loving Memory and Wouldn't You Rather.
The station have now released a video of the performance which can be watched below.
Following the release of Walk The Sky, Alter Bridge will head out on a UK and European tour. They’ll be joined in the UK by Shinedown and Sevendust, while Shinedown and Raven Age will hook up with Alter Bridge for the shows across mainland Europe.
Tremonti said previously: "We are honoured to be returning to the UK with our friends in Shinedown and Sevendust this winter.
“See you all very soon, we couldn’t be happier with the lineup and can’t wait to share our new tunes with you!”
Alter Bridge: Walk The Sky
1. One Life
2. Wouldn’t You Rather
3. In The Deep
5. Native Son
6. Take The Crown
8. The Bitter End
9. Pay No Mind
10. Forever Falling
11. Clear Horizon
12. Walking On The Sky
13. Tear Us Apart
14. Dying Light
Alter Bridge: Walk The Sky (opens in new tab)
Alter Bridge will release their new studio album Walk The Sky in October. The follow-up to 2016's The Last Hero features the lead singles Wouldn't You Rather, Pay No Mind and Take The Crown.


text:
Posted by col3neg on 25 Dec 2018 (8:18 PM). Hosted on the Internet.
The incumbent government had to allocate most of the country s revenues for social development, says Prime Minister Ranil Wickremesinghe. MORE..
22 Mar 2019 (7:00 PM)
Representatives of the Janatha Vimukthi Peramuna (JVP) today met with Prime Minister Ranil Wickremesinghe for a discussion on the proposed 20th Amendment to the Constitution. MORE..
22 Mar 2019 (4:42 PM)
Sri Lanka has successfully tested artificial rain for the first time in the country with moderate rainfall experienced over the Maussakele Reservoir for around 45 minutes. MORE..
22 Mar 2019 (6:39 PM)
Beliatta Pradeshiya Sabha Opposition Leader and UNP member Kapila Amarakoon, who was admitted to hospital with gunshot wounds on March 20th, has succumbed to injuries early this morning (22), the police spokesperson said. MORE..
22 Mar 2019 (10:21 AM)
A Singapore-based company in which stakes are held by the family members of former Indian Minister of State S. Jagathrakshakan of the DMK has been linked to a record foreign direct investment of $3.85 billion in an oil refinery in Sri Lanka. MORE..
22 Mar 2019 (11:57 PM)
The petition filed against Minister Rishad Bathiudeen, seeking the prohibition of deforestation at Vilaththukulam forest reserve in Wilpattu National Park, has been scheduled to be heard on June 28th. MORE..
22 Mar 2019 (1:56 PM)


New Delhi: Jindal Steel and Power (JSPL) on Tuesday said a 810 MW captive power plant at its Angul steel plant has been inaugurated by the company's Chairperson Emeritus Savitri Jindal.
"Minister of Haryana Government and Chairperson Emeritus of OP Jindal Group Savitri Jindal today visited Jindal Steel and Power Ltd's (JSPL) Angul Unit and inaugurated the 810 MW captive power plant of the 6 MTPA steel project," the company said in a statement.
It added that she also inaugurated a private airstrip at the Angul plant. Her son and company chairman Naveen Jindal was also present on the occasion.
"I am very happy that JSPL has adopted very environment friendly new technology for its steel plant. The Coal Gasification-DRI route will be the first of its kind in the world," she was quoted in the statement.
JSPL chairman Naveen Jindal said on the occasion that the coal gasifiers of the coal gasification plant (CGP) at the Angul unit are working well and soon the company will start producing sponge iron, using synthesis gas from the CGP.
Savitri Jindal is the Chairperson Emeritus of OP Jindal Group and a Cabinet Minister in the Haryana government.


The première of a new work by Armagh-born traditional musician and composer Niall Vallely, exploring the history and myths associated with the Navan complex. Commencing at the Navan Centre, the evening includes a dramatic performance by Armagh Rhymers, musicians from Armagh Pipers Club and audio-visual displays together with a promenade to the Fort itself. Come dressed for the weather as part of the performance is outdoors. The café is open for pre-performance. One of a series of four #embracetheplace public art events celebrating places of special cultural and historical significance, commissioned by Tourism NI through the Arts Council NI.


text:
Speaking before the NBA Draft Lottery on Tuesday night, commissioner Adam Silver was peppered with some Donald Sterling questions.
But in maintaining his stern approach toward the disgraced Clippers owner, Silver also paid Thunder star Kevin Durant a supreme compliment.
“Kevin Durant, as our Most Valuable Player, embodies what this league is all about,” Silver said. “Mr. Sterling doesn’t."
One of the few areas where the Thunder had the advantage over the Spurs in Game 1 was the free-throw line.
Oklahoma City got to the line more, shooting 23 free throws to San Antonio’s 17. The Thunder also shot a better percentage, 82.6 percent to the Spurs’ 76.5.
“We’ve got to attack more,” Durant said. “Offensively, we’ve got to continue to trust with the pass, move our bodies and be aggressive.”
The Spurs are all about precision and execution on offense.
And in Game 1 against the Thunder, all of that worked to perfection. The Spurs scored 122 points, shot 57.5 percent and scored 66 points in the paint.
Could physicality be the answer against the finesse?
“We want to make it hard for them to make all their cuts and their passes,” Thunder forward Nick Collison said. “They’re really good when they’re running through their offense and the ball is flying around and guys are wide open. We want to be able to throw their timing off a little bit.
“Some of that is physicality, but a lot of it is getting back and starting playing at the beginning of the possession instead of being back on our heels and letting them run where they want to run.”
DEFENSE TO OFFENSE
The Thunder offense struggled early in Game 1.
So did the defense.
Did the difficulties on the offensive end bleed over into the defense? The Thunder hit only two of its first 10 shots, while the Spurs nailed nine of their first 14 as they built an 11-point lead midway through the first quarter.
“I think you have to be able to defend regardless of whether you’re making shots or not,” Thunder veteran Derek Fisher said, “but at the same time, it helps if the ball is going in the basket to be able to get your defense back, set, to be confident.”
SPURS REACH MILESTONES
The Game 1 victory gave the Spur trio of Tim Duncan, Manu Ginobili and Tony Parker 110 playoff wins together, matching the NBA record set by the Lakers’ Magic Johnson, Kareem Abdul-Jabbar and Michael Cooper.
“It’s a wonderful accomplishment, as are a lot of things that we've done as a trio,” Duncan said. “But our only focus as far as we're concerned right now is winning this series and moving on.”
Also Monday, Parker had 12 assists, moving past Isiah Thomas into 10th place in NBA history for playoff assists. Parker now has 994 assists. Parker needs just 68 more assists to catch Larry Bird for fourth all-time. The record-holder is Johnson, with 2,346.
“It feels like a dream,” said Parker. “Coming from France and to arrive and accomplish all that. I feel very lucky and very blessed to be a part of a great organization and a great team, and being healthy all those years, and to pass a point guard that I really admired growing up, one of my favorite players, is just a great honor.”
GINOBILI BREAKS OUT
Another Thunder-Spurs Western Conference Finals. Another breakout performance by Ginobili. The 36-year-old Spur had 18 points, all in the second half, in Game 1. Ginobili averaged just 12.3 in the regular season. In the 2012 Thunder-Spurs series, Ginobili averaged 18.5 points a game, despite averaging just 12.9 during the regular season.
Ginobili said he wasn’t pressing in the first half Monday night: “Not at all. I didn’t have the opportunities to score a lot. Missed two layups, but the team was paying great. We scored 67. Of course, I always want to score more and play better. But that wasn’t the issue. The issue was we had to be ready for the run, because they were going to make a run, and we had to stay focused. And if in that second half I get to make the shots, great.”
PARKER FEELS GOOD
Parker has been battling a sore hamstring, but it didn’t seem to bother him in Game 1.
“I was concerned,” Parker said. “I didn't know how I was going to feel until we started the game.”
Parker said he realized early in the game it would feel fine. The hamstring tightened up some in the fourth quarter, he said, but by then the Spurs had the game in hand.


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Cancer diagnostics technology continues to evolve, with emerging science based in precision medicine beginning to dominate the industry. Even though global markets are primarily focused on cancer therapeutics, new trends in the development of cancer diagnostic technology will shape the future of these markets.
(Park City, UT) August 8, 2017—As efforts to develop better, more precise ways of diagnosing cancer continue, global markets need to shift focus towards emerging diagnostic technologies that will shape the future, according to NuView Life Sciences. Currently, markets are geared towards therapeutic applications, but current data shows that the growth of both in vitro and in vivo diagnostic markets will flourish through 2021.
According to recent data, the in vitro diagnostic market—which uses procedures that can be performed outside the body in a test tube, culture dish or elsewhere—will experience a 5.5% compound annual growth rate (CAGR) through 2021, eventually reaching a value of $78.7 billion.(1) Additionally, in vivo diagnostics—those that take place inside a patient’s body using various medical technologies, including non-invasive positron emission topography (PET) scans—is forecast to increase at a CAGR of 9.3% through 2021, eventually valuing $7.2 billion.(2)
One factor driving the increase in these markets is the exploration of precision medicine diagnostics, such as those currently under development at NuView Life Sciences. Patients with many types of cancer, including prostate, bladder, and breast, could reap the benefits of such technologies that will come to surpass the diagnostic accuracy of current technologies. Eventually, precision medicine diagnostic tests could become a routine part of health screenings and checkups worldwide.
Paul Crowe, CEO of NuView, says, “The potential in global diagnostics markets is virtually unlimited. There are already several minimally and non-invasive diagnostic options in clinical trials, including our own NV-VPAC1. We’re confident that our technology platform will help to change the focus of the markets towards diagnostics, instead of primarily concentrating on therapeutics.”
Another factor driving the increase in the global diagnostic markets is the increased safety and accuracy of these types of precision medicine-based technologies. NuView’s new technology platform, NV-VPAC1, uses a specific peptide sequence, combined with a medical imaging isotope, to correctly identify cancerous cells using PET scans. This non-invasive method of detecting cancer is superior to current diagnostic procedures, which often involve invasive, painful biopsies and other procedures that return inaccurate or questionable results.
For patients with prostate cancer, a shift in market focus could mean greater emphasis on developing and implementing precision medicine technologies in everyday healthcare. Currently, prostate cancer screening involves the prostate specific antigen (PSA) test using a blood sample from a patient. When PSA levels are high, many men are referred for further testing, including invasive biopsies.(3) Unfortunately for these patients, biopsies are often painful and can lead to a variety of complications, including infection, impotency and incontinence.(3) Furthermore, as many as 75% of men who undergo biopsy learn that their tumors are benign.(3)
Crowe says, “The fact that current diagnostic tests are often inaccurate and capable of causing profoundly negative side effects to patients is unacceptable. We’re confident that the technology we’re developing will help to revolutionize how many types of cancer, including prostate and breast cancer, are detected and conclusively diagnosed. This precision medicine-based technology is the future of the industry.”
In addition to the benefits to the patient, non-invasive precision medicine diagnostic technologies could also save millions for the entire healthcare industry. Healthcare facilities may only spend a few hundred dollars to utilize a platform such as NV-VPAC1 instead of spending thousands on other invasive diagnostic tests that may not even yield accurate results. Globally, this could help save billions of dollars in wasted diagnostic procedures, while still providing patients with definitive results in which they can be confident.
About NuView Life Sciences:
Founded in 2005, NuView Life Sciences is a biotechnology company located in Park City, Utah, working to improve the way cancer is diagnosed and treated in our modern healthcare system. NuView is focused on creating precision cancer diagnostics and therapeutics to improve patient outcomes while reducing healthcare costs through the development and clinical application of its exclusive peptide analog technology, NV-VPAC1.
Led by a team of industry experts with decades of combined experience in healthcare and medical imaging technologies, NuView is poised to change how we look for and respond to cancer. To learn more about NuView Life Sciences, please visit http://nuviewinfo.com/.
- In Vitro Diagnostics/IVD Market by Product (Instruments, Reagents, Software), Technology (Immunoassay, Clinical Chemistry, Molecular Diagnostics, Hematology), Application (Diabetes, Oncology, Cardiology, Nephrology, Infectious Diseases)—Forecast to 2021. MarketsandMarkets. http://www.marketsandmarkets.com/Market-Reports/ivd-in-vitro-diagnostics-market-703.html?gclid=Cj0KCQjwwevLBRCGARIsAKnAJvc0owVQjewDYGmav977OMNCqtq5jL6frYeKcFbBHQt78T8fFJ0BTC4aAhnWEALw_wcB.
- Nuclear Medicine/Radiopharmaceuticals Market by Type (Diagnostic (SPECT – Technitium, PET – F-18), Therapeutic (Beta Emitters – I-131, Alpha Emitters, Brachytherapy – Y-90) & by Application (Oncology, Thyroid, Cardiology) – Global Forecasts to 2021. MarketsandMarkets. http://www.marketsandmarkets.com/Market-Reports/radiopharmaceuticals-market-417.html?gclid=Cj0KCQjwwevLBRCGARIsAKnAJvekjgXPt8TZmdAOVcF1mCiytEitnej7spLsDTVk5jVi5YJ2IHaMTj8aAk-fEALw_wcB.
- Prostate-Specific Antigen (PSA) Testing for Prostate Cancer Screening. net. http://www.cancer.net/research-and-advocacy/asco-care-and-treatment-recommendations-patients/prostate-specific-antigen-psa-testing-prostate-cancer-screening.


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Awesome Oatmeal Chocolate Chip Cookies
- 1/2 cup 1 stick butter, softened
- 2/3 cup light brown sugar packed
- 1 large egg
- 1/2 teaspoon vanilla extract
- 3/4 cup all-purpose flour
- 1/2 teaspoon baking soda
- 1/2 teaspoon ground cinnamon
- 1/4 teaspoon table salt I often use a half teaspoon, but I like more salt in my baked goods
- 1 1/2 cups rolled oats
- 3/4 cup chocolate chips
Preheat the oven to 350 degrees.
In the bowl of you mixer add the softened butter, brown sugar, egg and vanilla extract. Mix the ingredients until light and fluffy.
In a separate bowl whisk together the flour, baking soda, cinnamon and salt.
Set the mixer to low and slowly add the flour mixture to the whipped butter.
Then add the oats and mix.
Finally add the chocolate chips and mix.
Chill the dough for 30 minutes.
Portion the dough into 1tbs portions and space them about 2 inches apart. Bake them for 10-12 minutes or until they are lightly browned around the edges. Remove from the oven and let cool on the cookie sheet.
Adapted from Smitten Kitchen - http://smittenkitchen.com/blog/2009/02/thick-chewy-oatmeal-raisin-cookies/

domain: food


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Addition of the BCL2 inhibitor venetoclax to endocrine therapy does not improve clinical benefit in patients with ER-positive, HER2-negative, locally advanced/metastatic breast cancer, according to the primary analysis of the phase 2 VERONICA trial.
For patients with ER-positive, HER2-negative metastatic breast cancer, CDK4/6 inhibitors combined with single-agent endocrine therapy is standard first-line treatment. Nevertheless, most patients progress. A potential novel therapeutic target is the antiapoptotic protein BCL2, which is overexpressed in 85% of primary ER-positive breast cancers.
Venetoclax is a potent, selective and oral BCL2 inhibitor, already approved in several haematological malignancies, that has shown promising clinical activity in patients with ER-positive and BCL2-positive metastatic breast cancer who have received prior endocrine therapy [1,2]. The VERONICA trial (NCT03584009) included 103 patients with ER-positive, HER2-negative, metastatic breast cancer who had progressive disease after ≤2 lines of treatment (including a CDK4/6 inhibitor).
Participants were randomised 1:1 to receive venetoclax (800 mg daily) plus fulvestrant (500 mg day 1 and 15 of cycle 1; day 1 of subsequent 28-day cycles) or fulvestrant alone until disease progression, unacceptable toxicity, withdrawal of consent, death, or predefined study end. Primary endpoint was clinical benefit rate (complete response, partial response, and stable disease ≥24 weeks).
Prof. Geoff Lindeman (Peter McCallum Cancer Center, Australia) presented results from the primary analysis . Clinical benefit rate was similar between arms: 11.8% and 13.7% for venetoclax plus fulvestrant and fulvestrant alone, respectively. Median progression-free survival was 2.69 months versus 1.94 months, respectively. Overall survival data were not mature. Based on the results of this primary analysis, venetoclax in second (or later) line does not seem to benefit patients with metastatic ER-positive, HER2-negative, metastatic breast cancer, Prof. Lindeman concluded. “However, it remains unclear whether a BCL2 inhibitor would be effective in an endocrine-responsive, CDK4/6 inhibitor-naïve setting.”
1. Rozeboom B, et al. Am J Cancer Res. 2019; 9(12): 2821–2831.
2. Lok SW, et al. Cancer Discov 2019; 9: 354-69.
3. Lindeman GJ, et al. Results from VERONICA: A randomized, phase II study of second-/third-line venetoclax (VEN) + fulvestrant (F) versus F alone in estrogen receptor (ER)-positive, HER2-negative, locally advanced, or metastatic breast cancer (LA/MBC). ASCO 2021 Virtual Meeting, abstract 1004.


When a franchise releases a new part year after year, the question remains.
The big American Football franchise returns yearly, but this is Madden’s first time getting an extensive story mode. The mode called: Longshot, puts a headliner in the spotlight to work towards the top of the league.
For “Madden NFL 18” is the first story in the story of the series own story mode called “Longshot” received. In this, the players will slip into the role of the former five-star high school quarterback Devin Wade, who, after a three-year break, tries to find the way to the professional league on the NFL Draft Day.
After NFL superstar and New England Patriots quarterback Tom Brady was the cover star of the football simulation “Madden NFL 18”, Patriots fans worried about the “Madden” -bundle. This was reason enough for Brady to release a new video in which he took the curse on the scow.
In the past few years it has never been a good sign for the NFL fans, if a player of their favorite team had found their way to the cover of the video game. For the cover stars were regularly visited by the notorious “Madden” wing, which in the best case only a weak season performance of the respective player and in the worst case a serious injury means. Last year, Brady’s team colleague Rob Gronkowski, Tight End of the New England Patriots, was on the cover of “Madden NFL 17”. Of course, he had so badly injured the following December that he missed the complete playoffs and the Super Bowl.
“Madden NFL 18” was already released on August 25, 2017 for the PlayStation 4 and Xbox One. In addition to a standard version, a G.O.A.T. edition will also be available. Are you excited to know the big update currently? It must be a pleasant journey. Just gather cheap mut 18 coins for sale on Madden-Store to start your wonderful experience.


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Jen Padron has seen multiple benefits for developing programmatic models of Peer Workforce deliverables. You will learn how to apply the Certified Peer Specialist and Endorsements (Vet to Vet, Family to Family, Transition Age Youth, Recovery Coach, Forensic Recovery Specialist) to support Peer to Peer initiatives nationally.
The Pre Conference is for Peer based Providers in the US States offering Medicaid Waiver opportunities for a 2018 roll-out. A brand new US Public Schools Secondary Environment Transition Age Youth Certified Peer Specialist Recovery Coach business model will be used as the working example for developing your fiscally sustainable P2P wrap-around supportive portfolio.
Every 98 seconds, someone the US is sexually assaulted. This is unacceptable. With the re-energized #metoo campaign and news stories regarding sexual violence almost daily, let's get to the facts. Let's acknowledge the reality that 1 in 5 people live in. Let's address what survivors face in the aftermath, and how we can better support and advocate. Let's call out false narratives and demand accountability. Let's create safer, more informed communities. Let's do something.
Many of us with psychiatric labels have been told we are "out of touch with reality." But what is reality? How does it work? In this workshop we will examine new ways to view reality that are inclusive even to those who live with unusual experiences. We will also examine the science of reality. Is it possible that those of us diagnosed with “mental illness” are actually experiencing a deeper reality, not a delusional one?
This workshop is an introduction to HVN facilitation skills. Participants will learn practical techniques they can use when working with any kind of group. These ideas are also useful when navigating our own life experiences. We will focus on exploring meaning rather than adhering to psychiatric labels. We will come together as experts-by-experience, learning about HVN's history, its charter and values, as well as core concepts that make Hearing Voices groups so innovative and unique.
A mix of information about successful Peer-Run Respite models in the United States. We will take time to gather input about what people want our Oregon Peer-Run Respites to look like.
Intentional Peer Support by Shery Mead (IPS):
3 principles: Helping to Learning, Fear to Hope, Individual to Relationship
4 Tasks: Connection/Worldview/Mutuality/Moving Towards
What are the various roles of peer and human services supports and how does IPS apply. IPS provides a relationship based model to maintain authentic and holistic foundation which allows for mutually walking with individuals. The word Intentional in IPS, specifically means intentionally doing something different and non traditional.
Have you ever wondered what it is like to attend a substance based recovery meeting? We will discuss various types of community based substance support groups including popular 12 step meetings such as Alcoholics Anonymous and Narcotics Anonymous. We will also discuss offshoots of these two programs including MA, GA, OA, HA and CMA. You will also learn about meeting formats and what to expect from less mainstream meetings including SMART Recovery, Celebrate Recovery and SOS.
This workshop will introduce participants to cognitive liberty, i.e. the right to experience any thought, feeling, belief, and expression of such, as long as they are not harming others. The workshop will discuss how the ideas of cognitive liberty scholars and advocates apply to various marginalized groups, including people diagnosed with mental illness and people in the substance use community. The workshop will also discuss barriers to cognitive liberty such as forced treatment and criminalization.
This workshop will serve as an introduction to the process of writing memoirs and personal stories for those who wish to write about their lived experience of emotional distress, trauma, and/or human rights abuses within the mental health system. Participants will learn the basics of story structure, character development, and narration as applied to creative nonfiction. They will also learn how memoir writing can be useful tool in both healing and advocacy.
A presentation/discussion of normal human and system patterns which can unintentionally undermine an organization/system's implementation of "Nothing About Us Without Us." This work session will use didactics, discussion, and a vignette to assemble a collection of options for preventing unintended impediments to inclusion, collaboration, and coalition-development.
Using a mix of hands on experience, observation and talk, this session seeks to explain how our own perception of situations and individuals influences how we approach them. Seeing people through other lenses allows us to expand our thought process and use perception to reach out in the most effective and meaningful way. Focused on adult learners to maximize retention of material.

domain: psychology


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Farmer Veteran Coalition news
On the 11th hour, of the 11th day, of the 11th month, fighting in World War I stopped. At the time, President Woodrow Wilson declared it the first Armistice Day. In 1954, the federal holiday was officially named Veterans Day to honor all American veterans.
The National AgrAbility Project, led by Purdue University’s Breaking New Ground Resource Center, is presenting “Veterans Harvest: A Virtual Conference for Veterans in Agriculture” this summer.


Smoke detectors going off for no reason
Asked Feb 12, 2009, 06:29 PM
Battery operated smoke detectors going off for no apparent reason. First, batteries were replaced and it continued to happen. Then, three new smoke detectors were purchased, installed, and all new batteries used in the new detectors. The smoke detectors are still beeping just like before -- not all the time -- but are all still doing it. What is going on? Have you seen or heard of this before? These are not wired into the security system.


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MEXICO'S STRUGGLE FOR PUBLIC SECURITY: ORGANIZED CRIME AND STATE RESPONSES
George Philip, Susana Berruecos, eds.
(New York: Palgrave Macmillan, 2012), 204 pages.
Mexico's Struggle for Public Security: Organized Crime and State Responses--a new examination of Mexican organized crime--stands above the many publications already issued on this subject. A product of the London School of Economics' (LSE) annual Conference on Mexico, this publication is an insightful and multidisciplinary analysis on Mexico's public security issues, which provokes thoughtful reflection on a complex reality.
The book's opening chapters focus on understanding the causes behind the increased levels of violence. Contrasting viewpoints pit the current administration's strategy of countering organized crime through security policy, social policy, and institutional reform, put forth by the current Minister of Government Alejandro Poire, against a framework that challenges the government's strategy of capo arrests and cartel fragmentation. The conflicting arguments presented here speak to an unbiased commitment to promoting a thoughtful debate on central questions, namely: What are the implications of today's security policy efforts for the future, and how do they point a way forward?
A particularly interesting section of the book provides an analysis of reforms undergone by the criminal...

domain: library


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State-of-the-art network based radar transceivers and a new generation of a revolutionary navigational radar and chart radar software.
Intuitive, future-proof and very cost-effective ECDIS.
A state-of-the-art integrated naviga-
tion system (INS), combining all relevant navigation sensors and
systems in a modular, user-centered system for safer and more efficient
Digitalized books with high data quality and global data access.


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Infinix has announced a grand sale, starting on the 12th of December. You can win exciting gifts and special discounts on a wide range of Infinix products including Infinix Smart 4, Hot 8 (32GB), Smartwatch, and X band 04.
With the purchase of every S5 (128GB), S5 Lite and X band 05 Infinix will offer special gifts to its customers. To avail this opportunity, all you have to do is follow Infinix Pakistan’s official Facebook page.
To make this grand sale more entertaining and fun Infinix is also holding a live session on the official Facebook page on the 12th December at 6 PM. The live session will host a well-known and tech-savvy YouTube content creator Bilal Munir from VideoWaliSarkar.
Commenting on this event, Mr. Joe Hu, Country Manager of Infinix Pakistan said,
Satisfying the ever-changing demand of the customers has always been the top-most priority of Infinix, therefore to make the blessed week more blessed we are giving away our most demanded Infinix products. We want to deliver beyond the expectations of our customers to improve their life technologically. Infinix is rapidly emerging as an innovative technology brand, aiming to deliver exceptional services to the rapidly expanding segment of smartphone users in Pakistan at very competitive prices.


Copper has thermal conductivity characteristics and antibacterial properties. It is an essential element to the human body. Resistex® Copper is a high-tech yarn obtained by the union of natural or artificial fibers with pure copper.
Copper yarn by Resistex® is antimicrobial because it eliminates a broad-spectrum of microbes, working on microorganism cell walls. Thanks to this property, silver helps to reduce bad odor caused by some microbes.
It is antistatic because of its conductivity, the fiber absorbs and disperses electric charges accumulated from the environment or during physical exercise.
It is permanent because thanks to its particular structure, it maintains a constant effectiveness over time, even after many washings. Copper is antioxidant and helps fighting free radicals, which causes the aging.
It is beneficial for the human body, as copper is necessary for the growth and for the metabolism. It is essential for good health.
Copper yarn is thermoregulator; it speeds up the evaporation process of perspiration, slows down humidity on the skin and keeps the temperature constant.
In a human body copper is essential for children growth, bone strengthening, the formation of red and white blood cells, iron transport, cholesterol and glucose metabolism, heart contraction and brain development. A deficiency of copper, on the contrary, can lead to health problems.
- COTOR -> 62% cotton, 38% cooper
- NYROM -> 40% polyamide, 60% copper
Visit Resistex ® website for further information http://resistex.com/prodotti/copper/


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- In order for immunotherapy checkpoint blockers to work, the tumor has to be recognized as foreign by the immune system.
- Most brain tumors, however, lack large numbers of mutations — making the tumors less covered with neoantigens, red flags signaling cancer.
- However, some high-grade meningiomas are different, harboring mutations that produce neoantigens. They have been found to harbor mutations that produce neoantigens, making them potentially vulnerable to treatment with checkpoint blocking immunotherapy drugs.
Six years’ worth of repeated surgeries, radiation, and chemotherapy with three different agents failed to halt the growth of Frances Zichichi’s brain tumor. As it kept recurring and more surgeries were required, Zichichi lost the use of her left side. Eventually the cancer formed masses under her scalp, causing pain, which was dulled only with narcotics, and intense headaches, which were treated with steroid drugs.
Then, in 2016, she went on a new clinical trial. She received the checkpoint blocker drug nivolumab, an immunotherapy drug which releases the immune system from molecular “brakes” that keep it from attacking cancer cells. Over the next few weeks and two doses of nivolumab, however, the tumors continued to grow. Her scalp pain and headaches got even worse.
“Her physical exam and MRI appeared consistent with progressive disease, and we withheld further nivolumab,” wrote the researchers, led by David Reardon, MD, clinical director of the Center for Neuro-Oncology at Dana-Farber Cancer Institute, in a report in JCO Precision Oncology.
Surgeons then performed a “debulking” procedure to remove the scalp tumor, and when the tissue was examined by pathologists, it yielded a big surprise. That night Reardon got a phone call from the lead surgeon who was very excited to report that everything that was removed was dead tumor. What had looked like worsening disease was “pseudo-progression.” The nivolumab had worked – and worked dramatically.
“Ever since that day, she’s been tumor-free,” said Joseph Zichichi. Frances continued with nivolumab treatment every other week for two years and last September, she and her husband, in consultation with Reardon, decided to stop it – though she still is observed with periodic imaging scans.
Zichichi’s type of cancer, a meningioma, is the most common primary tumor of the central nervous system, diagnosed in about 28,000 people a year in the United States. Meningiomas tend to be slow-growing but can cause problems if they expand and press on crucial parts of the brain. A subset of meningiomas, like Frances’, can be quite aggressive. There are no approved systemic therapies for meningiomas that keep recurring after surgery or radiation.
Immunotherapy checkpoint blockers only work if the tumor can be recognized as foreign by the immune system. The reason behind this, scientists are learning, is that the more DNA mutations a tumor has, the more it will be studded with “neoantigens” that are like red flags signaling cancer: This increases the chance that the immune system will recognize the tumor as foreign and launch an attack. Unfortunately, because most brain tumors lack large numbers of mutations they generally don’t respond to treatment with checkpoint blockers.
However, high-grade meningiomas such as Zichichi’s are different. They have been found to harbor mutations that produce neoantigens, making them potentially vulnerable to treatment with checkpoint blocking immunotherapy drugs. This was the thinking behind the clinical trial that tested nivolumab in patients with high-grade meningiomas that recurred following surgery and radiation therapy.
The results from the phase 2 trial haven’t been published yet, but Reardon says 25 percent of patients in the trial have had their tumor progression stabilized for at least six months. Zichichi is the only patient in the trial who has experienced such a dramatic outcome. That makes her an “exceptional responder” in the parlance of clinical trials, and the researchers launched an effort to discover the source of her tumor’s vulnerability to the drug.
Using the Oncopanel DNA sequencing platform, part of Dana-Farber’s Profile genetic screening research program, scientists analyzed samples of Zichichi’s tumor taken at different points in her treatment, looking for mutations and copy number variations in 447 cancer genes. The investigators were especially interested in the “tumor mutational burden,” or TMB, a measure of the number of mutations that could produce immune-stimulating neoantigens. They also homed in on immune cell activity in tumor specimens taken before and after she began immunotherapy with nivolumab.
With these and other methods, the researchers created a molecular profile of Zichichi’s tumor that revealed factors in its exquisite sensitivity to nivolumab immunotherapy. The meningioma tumor cells were found to be lacking the normal repair mechanism that enables them to heal breaks in DNA – making them more susceptible to cancer therapies. In addition, the tumors had a high tumor mutational burden – much higher than the average TMB in 228 meningioma samples analyzed in the Profile project. Together, the defective repair mechanism and high number of mutations in Zichichi’s tumor are believed to account for her exceptional response to nivolumab.
With these clues in hand, the scientists analyzed samples of 1,080 meningiomas and found that only a small minority – about 2.5 percent – exhibited high tumor mutational burden. Still, they said in their report, this dramatic response to nivolumab “indicates that screening meningiomas is warranted to identify a molecularly-defined subtype likely responsive to immunotherapy.”
Other authors of the report include Sandro Santagata, MD, PhD, and Ian F. Dunn, MD, of Dana-Farber and Brigham and Women’s Hospital; and Ziming Du, MD, PhD, of Brigham and Women’s.


- An ex-Marine who was arrested for his role in the U.S. Capitol riots previously went viral for rescuing dogs during Hurricane Florence
- Southport Marina receives new docks after Hurricane Isaias
- Hurricane-damaged Little Bay Primary School in Rockport to become a workforce center
- NHL postpones two additional Carolina Hurricanes games
- Ava Gardner Museum closes due to flood damage
Potential Tropical Cyclone 6 is forecast to strengthen to Tropical Storm Florence on Friday and then a hurricane by Sunday morning.
The National Hurricane Center is issuing advisories on Potential Tropical Cyclone 6, which is forecast to strengthen to Tropical Storm Florence and then a hurricane by Sunday.
It would be the third hurricane of the 2018 season, following Beryl and Chris.
The potential tropical cyclone is in the far eastern Atlantic, about 425 miles east-southeast of the Cabo Verde Islands with maximum sustained winds of 30 mph.
Ahead of the approaching storm, the government of the Cabo Verde Islands has issued a Tropical Storm Warning for the southern islands of Santiago, Fogo and Brava.
A Tropical Storm Warning means that tropical storm conditions are expected somewhere within the warning area within 36 hours.
The Hurricane Center reported in its most recent advisory that maximum sustained winds are near 30 mph with higher gusts. Strengthening is forecast during the next 48 hours, and Potential Tropical Cyclone 6 is expected to become a tropical storm during the next day or so.


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Paleo-Ketogenic: the WHY and the HOW
Craig Robinson, Dr Sarah Myhill
Sarah Myhill and Craig Robinson’s new book brings together all the guidance offered across their many other publications to show why a paleo-ketogenic diet is evolutionarily correct, and therefore the healthiest option, and how it can be practised affordably, easily and sustainably so that chronic ‘diseases of civilisation’ can be prevented or reversed. Discover how to prevent ‘the upper fermenting gut’ – the cause of the current epidemic of oesophageal cancer and other digestive problems. Find out how to clear out chronic infections and toxins and what to expect while doing so. Pick and choose from a selection of delicious low-carb whole-food recipes that will provide a high level of nutrients in the right balance. Just do it!
Please enter a quantity from the available format(s) below.
We use the Glassboxx service from Firsty Group for delivery of our eBooks. This makes it very simple and quick for you to get the books you’ve purchased, in lovely apps on iOS or Android smartphones or tablets.
If you already have the Glassboxx app on your smartphone or tablet, go to MY BOOKS to see your eBooks.
If you don’t yet have the Glassboxx app, go to the About eBooks page for more information and from there you can follow the app store links to download and install the app.


THE CDA’s withdrawal of a notification regarding the cancellation of allotment of a plot reserved for a Hindu temple and cremation centre demonstrates how crucial public pressure is to ensuring that the state takes affirmative action for minority communities.
In 2017, the CDA allotted four kanals of land to the Hindu community residing in Islamabad. But last year, because of pressure from right-wing religious groups, the CDA stopped the community from constructing a boundary wall around the land. It also emerged during a hearing of the Islamabad High Court on Monday that the CDA had cancelled the allotment of the temple site in February 2021 because construction had not begun. This led to criticism on social media, forcing the CDA to restore the allotment within a few hours.
With this move, around 3,000 members of the Hindu community in Islamabad and its adjoining areas might finally have a designated place to perform religious rituals and organise festivals. In contrast to the fickle-headed approach of the authorities, public pressure prevailed, enabling the government to stand by its decision of extending to the beleaguered Hindu community their constitutional right to practise their religion.
However, public pressure alone cannot do much if the state is unwilling to take action for the protection of marginalised groups. In this context, Chief Justice Gulzar Ahmed’s inauguration of a restored temple last week in Karak, KP, was a notable gesture of support for Pakistan’s minority communities. The Teri temple had been destroyed in December last year by a mob led by members of a far-right religious party.
His visit not only showed support of the highest court of the land to the Hindu community, it also sent a message to extremist groups that the state will not always surrender to their diktat. But though these are important steps, they are not enough unless combined with reformative changes such as those mentioned in the 2014 Supreme Court judgement authored by the then chief justice Tassaduq Jillani.
Published in Dawn, November 10th, 2021


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Canon Cameras US 14X32 is Image Stabilizing Binocular, Black (1374C002)
- High Magnification Ratio: 10x.
- Lens Shift Image Stabilization.
- 6.6 ft. (2m) Minimum Focusing Distance.
- Powered IS Mode with Microcomputer Control Technology.
- Improved Design and Comfortable Grip.
Get a whole new perspective - from bird watching to concerts and more - with the 10x32 IS Binoculars. Designed for extended comfort and boasting Lens Shift Image Stabilization and Powered IS, you won’t just get the experience, but feel a part of it.
- Product Dimensions: 5.7 x 6.7 x 3 inches
- Item Weight: 1.71 pounds
- Shipping Weight: 3.37 pounds
- Item model number: 1374C002
- Batteries: 1 AA batteries required. (included)

domain: design


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By PATRICK STEPHENSON
BRUSSELS – “We all know the power of fake news, and how difficult it is to address,” says Frederica Mogherini, the EU’s foreign and security policy chief, “Knowing the threat is essential, but not enough.” She addressed her remarks to a 2 October conference here, entitled “Hybrid Threats and the EU: State of Play and Future Progress.”
But what is a hybrid threat exactly? Daniel Fiott, security and defence editor at the Paris-based EU Institute for Security Studies, offered one definition riffed from Carl von Clausewitz. While the Prussian military theorist said that war is “politics by other means”, hybrid threats, according to Fiott, constitute “war by other means.”
That inversion of Clausewitz’s aphorism, however, holds a special challenge for Western governments in that some of their counter-efforts inevitably risk becoming propaganda themselves.
SECURITY EUROPE asked panellists how big bureaucracies such as the EU and NATO could counter fake news by producing its own counter-narratives. And could such narratives be construed as simply another form of propaganda?
Silvio Gonzato, Director of Strategic Communications at the EEAS, offered a distinction. “When we started, we were accused of doing counter-propaganda,” he said. “But fake news is a state strategy. Their narrative is, there’s no such thing as objective news. But we don’t just target those who are nice to us. StratCom needs to be placed within public diplomacy as an honest way of starting up a conversation and building up trust. We need to de-institutionalise the way we communicate, with real storytelling.”
Gonzato admitted that fighting fake news might involve an element of “pushing out our view of things”. But that self-promotion was acceptable. “We’re doing it in an honest way, and in a way that might be uncomfortable for us.”
Jyrki Katainen, Commissioner for competitiveness policy, later tried to explain the appeal of fake news, particularly regarding EU activities. “The main reason why people have fallen away from the reality of what the EU is doing, is that governments are not capable of explaining to their citizens what is the future of Europe,” he said. “If the top politicians don’t tell their citizens what the top 5 European priorities are, then what can you expect?”
In his remarks to the gathering Estonian Defence Minister Jüri Luik seemed to throw cold water on the EU’s efforts. “Countering hybrid threats is first and foremost the responsibility of national governments,” he said.
He did call, however, for an “EU-wide early warning system” for hybrid attacks against any EU member. “We will be attacked again,” he said. “It’s not whether but when, and who exactly, and on what scale.”
Indeed – and speed of response to hybrid attacks will be key. To wit: the EU-funded European Centre of Excellence for Countering Hybrid Threats, co-inaugurated in Helsinki on 2 October by Mogherini and NATO Secretary General Jens Stoltenberg, is already a target. Pro-Russian trolls have created at least two websites pretending to be the centre, with similar web addresses to fool curious visitors. The site is under serious attack, and it has barely started operating.
The conference’s last panel focussed on strategic communications, or StratCom, which was defined as a way of producing the counter-propaganda that earlier conference panellists had sought to avoid.
“We’re calling a spade a spade,” Maciej Popowski, deputy director-general for neighbourhood and enlargement negotiations at the Commission, told the conference. “We need to communicate in a strategic way, and we’re supporting independent media outlets in the Russian-language world.”
These questions were, for the most part, left unanswered. So the ‘counter-propaganda’ that was discouraged in the event’s morning session seemed eagerly embraced by the end – albeit with the less sinister-sounding name of ‘counter-narratives’.
The truth is that on the subject of information warfare, both the EU and NATO are still fumbling in the dark, at least when it comes to countering what the Russians are doing. They are squeamish about going full-on in the production of their own narratives because they are aware that such efforts would play into Russian hands.
But they are also hesitant to encourage ‘real news’ that doesn’t make their own institutions look good. The result is a boring, turgid, institutional muddle that few people would actually want to watch, or read, or listen to.


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[메디컬리포트=Maricor Zapata 기자]Photo by: typographyimages via Pixabay
Deaths because of HIV/AIDS have gone down dramatically the past decade globally.In 2015, about 1.1 million people died from HIV, down by 45 percent from 2005, and 26 percent lower than the HIV-related deaths in 2010, data from the World Health Organization stated.
Victory in the war against HIV/AIDS was the result of different approaches to battling HIV, such as the introduction of a vaginal ring in Africa, prescription of drug cocktails, and the provision of antiretroviral drugs (ARV) to HIV-infected infants.
About 75 percent of all HIV-related causes in 2015, or about 800,000 people, were from Africa.As the region with the greatest burden of HIV infection, it is apt that a new vaginal ring, called Dapivirine, will be tested in Africa after a six-month trial among teenagers in the US, which was successful.With the device's capacity to cut the chance of HIV infection by 56 percent, HIV-related deaths in the continent are expected to drop further in Africa at a faster pace.
The ring, which could be worn for a month, is treated with Dapivirine, an ARV.The function of the ring is to completely inhibit the reverse transcriptase enzyme of HIV.It is a protein that enables the virus to replicate and cause infections, Face2FaceAfrica reported.The flexiblering is placed on the cervix to protect African women from the virus.
Sharon Hillier, the principal investigator and vice chair of the University of Pittsburgh School of Medicine's Department of Obstetrics, Gynecology and Reproductive Sciences, wants the vaginal ring to become available to all African women regardless of age because HIV does not distinguish between a teen and an aging victim, and they all deserve protection.
When the vaginal ring was successfully trialed for six months on teenage American girls, who were sexually active, detectable levels of Dapivirne were found in their vaginas in 87 percent of the 96 trial participants.
HIV drug cocktail
Newly diagnosed HIV patients could benefit if they are prescribed a cocktail of HIV medication at the start of their treatment, doctors recommended. Deaths among patients who were given the cocktail declined by 27 percent, according to the results of a study, published in the New England Journalof Medicine, BBC reported.
Besides the 27 percent reduction in death, there were substantial declines in several HIV-related ailments when the trial was conducted in Zimbabwe,Uganda, Malawi, and Kenya on 1,805 patients, age five and above.The largest decrease was by 62 percent in cryptococcal disease, followed bycandidiasis (58 percent), and tuberculosis (28 percent), while hospitalization dipped by 17 percent.
The drug cocktail was given to HIV patients with CD count of less than 100.The cocktail included antibiotics and standard ARV drugs for HIV. A patient who has a CD count, which measures the health of the immune system, of below 50 has six times higher chances of dying within the next 24weeks compared with those with CD count higher than 100.
By just changing the HIV medication to the drug cocktail, over 10,000 lives could be saved each year.At the same time, the cocktail -- $5 moreexpensive than the standard treatment -- could also prevent TB, cryptococcal meningitis, and expensive hospitalizations, Professor Diana Gibb, fromthe MRC Clinical Trials Unit in the UK and co-author of the study, said.
ARV treatment for infants with HIV
An experiment more than eight years ago to treat an HIV-infected child in South Africa yielded good results, Sciencemag reported.The infant wasborn to a mother with HIV and was given ARV beginning when the baby turned eight weeks.The treatment was stoppedafter 40 weeks as part of the controlled clinical trial.
After eight and a half years, the virus has not returned.It did not imply that the child's HIV infection was cured, rather, low levels of the virus wereleft.When standard tests are used, the HIV is invisible, but it could be detected using ultrasensitive tests, Mark Cotton, an HIV/AIDS clinical researcherat the Stellenbosch University in South Africa, shared on July 25 at an international AIDS conference.
The treatment of the South African child is part of a large clinical trial, in which blood samples of HIV patients were collected and stored at regularintervals.However, it could be a one-off case because a similar one happened in Mississippi before.The baby had a similar history with the infant inSouth Africa, but unfortunately for the American baby who received media attention, the HIV rebounded after 27 months off treatment.
Meanwhile, at the Pasteur Institute in Paris, 23 patients in France began ARV treatment and their virus had remained undetected at an average ofseven years.In one patient, it was undetectable for almost 17 years.Another controlled trial with almost 200 patients showed that early treatmentcould lead to a long-term suppression of the HIV in at least some people, John Frater, a clinical researcher at Oxford University, said.


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KILLING JOKE frontman Jaz Coleman has paid tribute to the band's guitarist Kevin "Geordie" Walker who died on November 26 in Prague, Czech Republic after suffering a massive stroke. He was 64 years old.
Geordie was born in Chester le Street, Newcastle on December 18, 1958, and began his career in the late 1970s with seminal post-punk act KILLING JOKE with whom he would go on to write and record on 15 studio albums, earning worldwide critical acclaim and a ferocious fanbase. Geordie's utterly unique style drew widespread praise from fans and his peers alike.
Earlier today (Thursday, December 28),Jaz took to his Instagram to write: "My dearest Geordie, for days I have been staring at the blank paper in front of me unable to write anything. How does one begin to convey this immeasurable sadness within? Or reduce the last 45 years into a few paragraphs? The epic journey we have shared together – the hardships and the victories, thousands of concerts, the multiple lives we have experienced together in this short life across the world. None of it would have been possible without your unfaltering resolve. When the going got tough and the money ran out, others left – you never. Over four and a half decades the only constant witness was you. The only individual to have attended every single KJ concert and recording since our genesis.
"All of us who have ever loved KJ owe so much to you. I am overwhelmed by grief; nothing can fill the terrible void you have left for you were the other part of me. I spent more of my life with you than my own blood brother, or any other human being for that matter. And, although in recent years we were separated by my sobriety, you always knew I was never far away from you, and you could rely on me if you needed me.
"I wish I could've been by your side in your final hours to give you comfort. Nevertheless, I take solace that your dad Ron, Terry Cox, Raven, and Alan Glover were all waiting for you on the other side, and that you will wait for me when my time comes. We found each other before, and we will do so again.
"I want you to know how privileged I feel to have been the first person you met in London back in the seventies, and one of the last people to have an in-depth conversation with you before your parting. I know of your hopes, musical aspirations, and remaining goals for KJ – radical changes which you were both passionate and empathetic about. I know you will whisper in my ear and guide me in all my future endeavours. Thy will be done.
"Geordie, my beloved brother, you live in my heart for evermore. I shall never recover from your passing. Your work will shine on 'til the end of time.
"Your loyal and ever-loving brother. Jaz #jazcolemanofficial #killingjoke #geordiewalker".
In the days following Geordie's passing, KILLING JOKE's fellow original members Martin "Youth" Glover (bass) and Paul Ferguson (drums) also paid tribute to the guitarist. Youth said: "Still in shock and hard to believe he is no longer with us. Always seemed indestructible to me. Bullets bounced off him. He was truly destined to be.
"No man was cooler than Geordie, one of the very best and most influential guitarists ever. He was like Lee Van Cleef meets Terry Thomas via Noel Coward. Very charming, inscrutable and gracious, with a gentle effortless touch, ( both on the guitar and making you feel welcome) that is, when he wasn't shredding you with his razor sharp articulate shrapnel. He was a virtuoso gunslinger, both with his music and verbosity. He wouldn't hesitate to throw his flicknife into the mixing desk and demand a two bar count, not four, for his drop in, which always managed to focus the engineers attention ! He understood that the chemistry was the rub and that's actually where the magic and soul was ….in the conflict.
"He was my teacher, partner and at times a terrifying foe. Eternally grateful for the stars colliding that brought our fates together. He is now flying high with The Valkyrie's, on his way to the halls of Valhalla, where his seat at the table of legends is most certainly assured. He defined a generation or three with his genius.
"I am personally honoured and privileged to have served with him and share a vision with him of what the band could become and then see it go way way beyond that and what any of us could have imagined.
"Thinking of his family, mother and loved ones, band mates, all the fans, gatherers and many musicians he has influenced with his visionary playing and writing."
Ferguson said: "We are devastated by the news of our brother's sudden passing. Our collective look forwards have come to naught and the maestro strummed his last glorious chords. I was honored to play in the band with him, a rare talent and wit who suffered no fools. Rest in peace Geords."
KILLING JOKE emerged in the post-punk early 1980s, their eponymous debut album exhibiting funky heavy rock influences before electronic and synth-pop styles also filtered through their music. They would, in turn, influence later generations including METALLICA, NIRVANA and SOUNDGARDEN. "Love Like Blood" would give KILLING JOKE their greatest commercial success, a hit across Europe, peaking at No. 16 in the U.K. singles chart in 1985.
Walker and Coleman had been ever-constant members of the lineup and had been reunited with fellow founding members Ferguson and Glover since 2008.
In a 2006 interview with MTV, Coleman stated about Walker: "Working with Geordie Walker — he's a magic player. It's my deepest pleasure to have spent more years with him and more time with him than my own blood[-related] brother."
A decade ago, Walker told Metal Assault about how his guitar playing style has evolved over the years: "I just found the right instrument pretty early in the game, which is a hollow body. It has a bit of a life of its own. I think I'm starting to play with a little less violence on the right hand, which has helped me a lot in definition, if you know what I mean, and not breaking as many strings either, touchwood. I used to snap the D strings and be spiteful with certain chords."
This past March, KILLING JOKE released a brand new single, "Full Spectrum Dominance", via Spinefarm to celebrate the band's sold-out headline show at London's Royal Albert Hall. The epic track was mixed by Tom Dalgety (GHOST, PIXIES, ROYAL BLOOD) and was accompanied by a remix from Youth and artwork by longtime designer Mike Coles.
Under the banner "Killing Joke - Follow The Leaders", KILLING JOKE performed its first two albums in their entirety at the Royal Albert Hall — 1980's self-titled debut LP followed by their second full-length, "What's This For…!"
This special event was preceded by four intimate warm-up shows, including an appearance at London's legendary 100 Club.
Image above from 2018 KILLING JOKE press photo

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Kidney Cleanse Naturally Herbal Supplement for Dogs and Cats!
One essential aspect of your pet’s health that often goes overlooked is their kidney function. The kidneys play a vital role in removing waste and toxins from the body, but they can become overworked and overloaded over time. This can lead to a range of kidney problems, including urinary tract infections, kidney stones, and even kidney failure.
That’s why it’s crucial to support your pet’s kidney health with a regular kidney cleanse. A kidney cleanse can help to flush out toxins and impurities that may be putting stress on your pet’s kidneys. By doing so, you can help to prevent kidney problems and support your pet’s overall health and wellbeing.
Our unique blend of natural herbs and ingredients has been carefully formulated to gently cleanse and support your pet’s kidneys, helping to promote optimal kidney function and prevent common kidney problems.
Our supplement contains powerful herbal ingredients all of which have been shown to support healthy kidney function, and flush out harmful toxins and waste products from the body.
Our Herbal Kidney Cleanse supplement is the perfect solution for pet owners who want to take a proactive approach to their pet’s kidney health. Our all-natural formula is designed to support healthy kidney function and promote optimal kidney health. It’s easy to administer and free of harmful chemicals and additives, so you can feel good about giving it to your furry friend.
Don’t wait until your pet shows signs of kidney problems. Give them the gift of optimal health with our Herbal Kidney Cleanse supplement. They’ll thank you for it!
Signs your dog needs a kidney detox:
- Increased thirst and urination: If you notice that your pet is drinking more water than usual and having more frequent trips to the litter box (in cats) or going outside to urinate (in dogs), it could be a sign of kidney problems.
- Loss of appetite and weight loss: Kidney problems can cause a buildup of toxins in the body, leading to a loss of appetite and weight loss.
- Vomiting and diarrhea: Kidney problems can also cause gastrointestinal issues, including vomiting and diarrhea.
- Lethargy and weakness: If your pet seems more tired and lethargic than usual or is having difficulty getting up or moving around, it could be a sign of kidney problems.
- Changes in urine color and smell: If you notice that your pet’s urine is darker or has a stronger smell than usual, it could be a sign of kidney problems.
Whether your pet is suffering from kidney problems or simply needs a little extra support to maintain optimal kidney health, Kidney Cleanse Naturally herbal supplement is the perfect choice. It’s easy to administer – simply mix the recommended dosage into your pet’s food and watch as your furry friend enjoys improved kidney function, increased energy, and overall better health!
So why wait? Give your pet the gift of better health today with our Herbal Kidney Cleanse supplement for dogs and cats. Order now and see the difference for yourself!
Available in 8 oz jar, 16 oz bag
Recommended Detox: 1 x Day for 30 days
Maintenance Dosage- 7 Days 2 – 3 times per year
Under 10lbs- 1/4 small scoop
10 to 24 lbs – 1/2 small scoop
25 to 50lbs – 1 small scoop
Over 50lbs – 1 large scoop
8 oz- 80 small servings (approx)
40 large servings (approx)
16 oz- 160 small servings (approx)
80 large servings (approx)
Ingredients: Goldenrod, Dandelion Leaf, Marshmallow, Parsley, Garlic, Nettle, Flaxseed, Beef Flavor (2457 mg/teaspoon)
*Disclaimer: We make no medical or veterinarian claims to any of the products offered on this site. The information presented on the Alternative Animal web site is intended for informational purposes only. It is not intended to diagnose, treat, cure or prevent any disease and should not in any way be used as a substitute for the advice of your physician, veterinarian, or other licensed health care provider.
CAUTION. Safe use in pregnant animals or animals intended for breeding has not been proven. If animals condition worsens or does not improve, stop product administration and consult your veterinarian. An examination from a veterinarian is recommended prior to using this product.
WARNING. For animals use only. Not intended for animals under 6 weeks of age. Keep out of the reach of children and animals. In case of accidental overdose, contact a health professional immediately.

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Jay Watkins, UF Associate Director of Bands
Today’s episode features Jay Watkins, University of Florida Associate Director of Bands and director of the “Pride of the Sunshine” Marching Band - the official marching band for the University. Membership in the band is open to all students currently enrolled at the University of Florida or Santa Fe College. Students audition each year and currently the band consists of 425 undergraduate and graduate students that represent over 100 majors at the university.
The current era of the band is also referred to as The Sound of the Gator Nation. They perform at every Florida Gators home football game and also at various other events such as pep rallies, parades, and the annual Orange and Blue spring scrimmage game. UF students are encouraged to join other ensembles such as concert band, jazz band, basketball band, and volleyball band. Jay Watkins shares information on the UF music program and an upcoming Spring Break trip to perform at various venues in Ireland.
University of Florida Bands