text:
Delta Air Lines (NYSE:DAL) today announced it
will move forward with the $400 million redevelopment of Terminal A at
Boston`s Logan International Airport to enhance travel for customers in
Boston and the Northeast. To facilitate customer service during the
redevelopment project, Delta Shuttle operations will relocate from
Terminal A to Terminal B, starting April 7, 2002.
Delta Shuttle`s new gates on Terminal B will offer easy access to
passengers parking their cars or being dropped off at curbside. Located
directly across from the Central Parking Lot, Delta Shuttle will continue
to be the first stop for Massport transit and the first terminal stop on
the airport access roadway. All Delta Shuttle amenities and services, such
as self-service kiosks, streamlined check-in, as well as complimentary
newspapers and magazines, will continue to be offered in Terminal B.
Delta, Delta Express, Delta Connection carriers and international
codeshare flights will remain in Terminal C. Customers also will continue
to have access to Delta`s Crown Room Club in Terminal C.
In 1999, Delta made a strategic decision to increase its presence at
Boston, announcing a $400 million investment to upgrade and expand its
Terminal A facility. Estimated for completion in 2005, Delta`s Terminal A
will offer passengers a modern, state-of-the-art, customer-friendly
facility featuring improved access, expanded gate areas and enhanced
technology at ticket counters and gates to expedite check-in. Delta will
consolidate all of its operations in the new terminal which will be used
exclusively by Delta customers.


text:
theme, very interesting ))))))))))))))))))) matchless..
Sunshine Of Your Love - Funny Hippos - Pi-dą (CD, Album)
Label: Epic - 485063-2 • Format: CD Album • Country: Poland • Genre: Rock •
A Lover Like Me - Various - Daptone Gold (Vinyl, LP), Wichita Lineman - Larry Page Orchestra - Larry Page Orchestra (Vinyl, LP), Oxygene 1 (Laboratoire Mix) - Jean Michel Jarre* - Jean Michel Jarre CD2 (1989-2000) (CD), Destiny - Biel-Bienne Jazz & ImproOrchestra* - Derwish-Suite (CD, Album), Atrophy - Haloburn - Unspoken (CD, Album), Working’ Man - Various - New Breed Workin’ - Blues With A Rhythm (CD), Dont Give Up - Various - Top 100 Discocharts Vol. 1 (CD), The Real Shit - The Outhere Brothers - The Other Side (CD, Album), Chocolate & Peanut Butter (DJ Double Dee Hunts Point 7AM; Coco Mix) - Boogie Balo* - Chocolate & Pea, A Cops de Destral - Cruz (22) - Culto Abismal (Cassette, Album), If I Was A Ship - Hey Ocean! - Is (CD, Album), Eu Vou Querer - Os Maracatu - Alegria Do Brasil (8-Track Cartridge, Album), Cancion Del Regreso - Jorge Cafrune - Canta A La Patria (Vinyl, LP, Album), Two For Otis - Maynard Ferguson - The Essential Maynard Ferguson (CD) Shakara - Sérgio Mendes & Brasil 77 - Homecooking (Vinyl, LP, Album)
8 thoughts on “ Sunshine Of Your Love - Funny Hippos - Pi-dą (CD, Album) ”
High quality Album inspired Wall Art by independent artists and designers from around the alavbladsopfewas.stevankewealilighlapslingxeningtepart.infoinfo orders are custom made and most ship worldwide within 24 hours.
Become A Better Singer In Only 30 Days, With Easy Video Lessons! It's gettin' near dawn, When lights close their tired eyes. I'll soon be with you my love, To give you my dawn surprise. I'll be with you darling soon, I'll be with you when the stars start falling. I've been waiting so long To be where I'm going In the sunshine of your love. I'm with you my love, The light's shinin' through on you.
The song Sunshine of Your Love was written by Eric Clapton, Pete Brown [UK] and Jack Bruce and was first released by Cream in It was covered by Zlatni Akordi, Rusty Young and Sneaky Pete, Spyro Gyra, Wolff & Clark and other artists.
SUNSHINE OF YOUR LOVE As recorded by Cream (From the Album DISRAELI GEARS) Words and Music by Jack Bruce, Peter Brown & Eric Clapton A Intro 1 I T A B gg4 4 Gtr I Moderately P = V 12 V 12 V 10 f V 12 kV 12 ck V 11 c g kV 10 ck V 10 c V 8 f V 10 [[[[V 10 V sl. 12 V 12 V 10 f V 12 kV 12 ck V 11 c g kV 10 ck V 10 c V 8 f VFile Size: 48KB.
Automatically Sunshine Your Wonderful, Sweet, Sweet, Love I Guess I'll Miss The Man Stephen Schwartz Plane Jimmy Webb Bad Weather Stevie Wonder, Ira Tucker He's My Man Greg Wright, Karin Patterson Ain't Nothin' But A Party Sugarhill Gang Rappers Delight 8th Wonder Trip At The Brain Suicidal Tendencies How Will I Laugh Tomorrow When I Can't.
Get a special offer and listen to over 60 million songs, anywhere with Amazon Music Unlimited. Get a special offer and listen to over 60 million songs, anywhere with Amazon Music Unlimited.5/5(1).
I'll soon be with you my love, To give you my dawn surprise. I'll be with you darling soon, I'll with you when the stars start falling. I've been waiting so long TO where I'm going. In the sunshine of your love. Moderate Rock = Gtr. 1 (dist.) D' DECEMBER ON THE CD GNX4 Guitar Workstation Powered Download presets at alavbladsopfewas.stevankewealilighlapslingxeningtepart.infoinfo
Mar 21, · "Sunshine of Your Love" is a song by the British supergroup Cream. The song was originally released on the album Disraeli Gears in November and .

domain: artistic


text:
Antique Russian Orthodox icon showing Jesus Christ with angels. Finely detailed spiritual piece.
CONDITION: has wear due to age / not altered or restored
SIZE: 12.5" x 16.25"
MEDIUM: paint on wood
7 other shoppers are interested in this item
Original 19th and 20th century fine art


text:
Although 17 years have passed since the last broadcast of The Simulators, the most famous quartet on Argentine television still generates great emotions, and Netflix he knows. In a short video posted on his account Twitter Argentina, the streaming giant gave fans a small revival of the famous series.
In the clip you see Federico D’Elía back in the role of Mario santos, the team leader in charge of logistics and planning. The simulator returns to make one of its well-known mission reports, informing the rest of the group of a new mission for which they were hired.
Through the communicator that Santos addresses, we hear the voice of Alejandro Fiore that gets back into the skin of Raspberry, simulator in charge of technique and mobility in the team.
It is here that the true nature of the video is revealed: Santos is actually recounting the plot of another Netflix series, Lupine. The platform decided to recruit Simulators to promote the premiere of the second season of the French show, which from this Friday is available in its catalog.
After recounting the premise of the series and entrusting the operation to his colleagues, Santos addresses the camera. “Sorry, do you have fire?“, D’Elía ends, repeating the iconic phrase that his character said at the end of a successful operation.
The reaction of the fans
Fans of the Argentine series expressed their emotion on social networks, taken to Los Simuladores at Twitter trends. Many expressed their disappointment with the commercial, which they mistook for a possible return to the screen for the four protagonists played by D’Elía, Fiore, Diego Peretti and Martín Seefeld.
The same official account of Netflix He stood up to comments from disappointed fans, writing in a reply “I don’t lie, I don’t cheat, I only recommend Lupine part 2 which is already availableSeveral other users also received a response from the account, which addressed the slight complaints with humor:
BUT BUT BUT look at the promo I put in to tell you that Lupine, part 2 is now available
— CheNetflix (@CheNetflix)
June 11, 2021
It is not the first time that the protagonists of the acclaimed series flirted with Netflix about a possible return. In May 2019 three of the protagonists joined an intense thread discussing the lack of Argentineanisms in the Latin American Netflix account.
After Netflix’s question about the expression “handle”, D’Elía respodido again in the role of Mario Santos, and the rest of the team soon joined. The fun exchange turned out to be the announcement of the new official Netflix Argentina account, again leaving fans dreaming of the movie that, until now, was not.

domain: news


Men Photographed Breastfeeding to Raise Awareness
One man is taking up an unlikely cause: breastfeeding. Hector Cruz and his wife Nicole tried to conceive for over 10 years before Nicole became pregnant. After the birth of their daughter, Nicole had trouble breastfeeding.
Their doctor recommended switching to formula, but the determined couple turned to a support group for advice. Eventually, Nicole was able to breastfeed after working with a lactation consultant.
Soon after, Cruz kicked off a campaign to educate other men about the importance of breastfeeding. He founded Project: BreastFeeding last year. Cruz photographs men holding their babies in a breastfeeding position, along with the phrase, “If I could, I would.”
According to FoxNews.com, Cruz’s first photo shoot was with military families at Fort Campbell military base in Kentucky.
Today on Happening Now, Dr. Manny Alvarez said, “I think this is so cool.”
He said, “It’s a commitment that women do for their children which is very noble. We, men, have to be part of that process, encourage it, support it because at the end of the day it’s not only great for the children, but it’s wonderful for the mom.”
Read more about the campaign at FoxNews.com.


text:
It’s important to know that diarrhea is not an illness but a symptom of any number of problems that are interrupting the function of the large intestine.It is also important to identify the cause as trying to just suppress this symptom will only bring about short lived, temporary relief which may cause long term health implications. Once identified, different causes will require different treatments.
Diarrhea can be mild and self limiting, or very debilitating and even fatal. It may or may not be accompanied by gas and abdominal discomfort. If your dog is still happy, with good energy level, and doesn’t refuse water an acute episode of diarrhea may be the body’s attempt at internal cleansing and purging. If however the diarrhea persists for more than a few days, contains blood, if there is associated vomiting, your dog is becoming increasingly lethargic, and refuses to drink, please seek the advice from your veterinarian as soon as possible. With each passing day of chronic diarrhea nutrients are lost in the stool, which lowers your dog’s general vitality. Your dog may need to go on an IV for loss of fluids immediately if this is the case.
Causes and Contributing factors to diarrhea
A dog with chronic diarrhea and gas, and accompanying skin problems may be suffering from a food allergy. Frequent offenders are preservatives (ethoxyquin, propylene glycol), artificial flavouring and coloring, dyes, salt, sugar, fungi, bacteria, germs all found in commercial dog foods (read more about What’s Really in Your Dogs Food article). Most common foods that may cause allergy include: beef, beef by-products, corn and corn oil, fish, turkey, pork, ham, cows milk (lactose intolerance), yeast, eggs, wheat or any food containing these. Please note that all commercial tinned food and biscuits, treats all contain sugar, salt, corn and wheat. Unless diet is strictly addressed, ongoing diarrhea may continue presenting.
Consider also the following contributing factors diarrhea may be due to:
• stress and anxiety
• over eating
• high fat diet
• vaccinations (due to meat extract that certain vaccines are grown in, thus long term leading to sensitivities and autoimmune disorders)
• undiagnosed IBS (Irritable Bowel Syndrome)
• leaky gut syndrome (intestinal dysbiosis/ hyper permeability)
• a foreign body ingestion
• gastritis, colitis (intestinal inflammation)
• the pancreas and/or liver failing to produce enzymes properly or sufficiently
• food poisoning
• excess vitamin C
• bacteria, virus (i.e. parvovirus, distemper)
• parasites i.e. worms
• drug related complication (most drugs are residual and are never completely eliminated as in the waste from food but are stored up in the body)
• side effect of certain drugs (i.e. antibiotics)
• liver disease
• stomach ulcer
• could also indicate that the liver and kidneys are overwhelmed with toxins that they are unable to process which leads to purging i.e. diarrhea.
Helpful suggestions to relieve diarrhea
The most beneficial initial step is to put your dog on a liquid fast. Withhold all solid food and only …

domain: medical


text:
Xbox Series S: Microsoft's budget console outsells the Xbox Series X, PlayStation 5 and the Nintendo Switch during Black Friday promotions
While the PlayStation 5 and Xbox Series X remain sold out, even the PlayStation 5 Digital Edition, plenty of Xbox Series S consoles are available. As it stands, Best Buy has stock of the Series S for US$299.99, with the console selling for £249.99 on Amazon UK.
During Black Friday and Cyber Monday, retailers were selling the Series S at a modest discount, if they offered one at all. Nonetheless, Adobe Digital Economy Index has found that the Series S has sold exceptionally well over the consecutive promotional periods. Reportedly, the Series S outsold the Nintendo Switch too, not just the largely unavailable PlayStation 5 and Series X.
Until now, the lack of cutting-edge hardware in the Series S has depressed its adoption. Presumably, people have been purchasing the Series S as Christmas presents, given the sudden rise in sales.
For reference, the Series S offers up to 4 TFLOPS of performance, a third of the Series X. The Series S is also only available with 512 GB of storage, compared to the 1 TB in the Series X. Crucially, the Series S lacks a disc drive, meaning that you must rely on a digital-only game library.

domain: game


text:
Ellieil y a 2 mois
|Expérience:||Moins d'1 an|
|Autres langues parlées:||tagalog|
|Tarif horaire:||6 - 8 euros|
À propos de Ellie
Hi there! My name is Ellie and currently work full time as Legal Assistant in Vancouver, BC. I am seeking to be a part-time babysitter for those parents that need their alone time or are wanting to go on date night.
You may see that I have zero experience as a babysitter, however, I grew up caring for my little cousins so I have some experience in child care. I also studied Nursing for two years so I have basic knowledge in health and first aid. I am available on the evenings from Monday to Friday. I am also very flexible on the weekends.
On my spare time, I love watching my favorite shows or being a tourist in my own city. I am a certified bookworm and have been ever since I was young so there will be lots of storytelling at your household. I love playing with kids and getting creative with them with arts and crafts!
Please message me if you would like an interview to see if we are a great fit :)
Nous avons envoyé un email à l'adresse :email
Cliquez sur le lien contenu dans l'email pour confirmer votre adresse.
Vous n'avez pas reçu d'email ? Assurez-vous de nous avoir indiqué la bonne adresse email et vérifiez vos spams.

domain: hobby


text:
The model, who was linked to Brad Pitt and Pete Davidson, shared her perspective on being single on her recent podcast
Emily Ratajkowski is airing her grievances about the other Sєx.
On the latest edition of her High Low with EmRata podcast, the 31-year-old model shed some light on her recent relationships, since splitting from husband Sebastian Bear-McClard.
“I feel like I attract the worst men,” the My Body author said. “Sometimes I’m like, f–k, because I want a confident man. I don’t want an overly confident man who has something to prove and is trying to prove it through me. That is not what I want.”
Ratajkowski also said the dynamic is something that has contributed to her ambivalent feelings she has towards courtship, four months after filing for divorce from the Uncut Gems producer, with whom she shares 22-month-old son Sylvester Apollo.
“That’s what I hate with dating … men in particular,” the Gone Girl star said. “They’re like, ‘OK, yes, you’re special. You’ve done it.’ And they love it and love it, and then slowly they get emasculated and don’t know what to do with those feelings, and then they resent you. They start to tear you down, and then you’re back to square one.”
She added, “And it’s so f–ked up and unfair, because I feel like a lot of men who truly think they want a strong woman actually don’t know how to handle it and … what it means for their own idenтιтy,” she said.
In the wake of her separation from Bear-McClard — to whom she was married for four years — the star was briefly linked to Brad Pitt and dated Saturday Night Live alum Pete Davidson.
Despite the challenges of dating, Ratajkowski told Variety in October that she was savoring being “newly single for basically the first time in my life ever.”
“And I just feel like I’m kind of enjoying the freedom of not being super-worried about how I’m being perceived,” she told the publication.
In addition to her podcast, the star also has found TikTok to be a balm during her life as a singleton, and frequently uses her account to tackle gender-related topics.
She admitted to Variety that she gets plenty of criticism for being outspoken about her views.
“Women seeking attention is always the classic misogyny H๏τ topic. It’s really what gets people going, to accuse a woman of seeking attention. Personally, I know that really well,” she said.
She added, “So, yeah, I get a lot of hate. But as they say on TikTok: ‘The girls who get it, get it.’ That’s my motto these days.”

domain: celebrity


Modi's silence on Prophet row very meaningful: Hamid AnsariJune 11, 2022 21:05
Former vice-president Hamid Ansari has said it is not fair to claim that those who made controversial comments about Prophet Mohammad were "lightweight" and underlined the government had been "mum" when anti-minority and anti-Muslim hate speeches were made at various 'Dharm Sansads'.
He also said that Prime Minister Narendra Modi's "silence" on the matter was "very meaningful" and not accidental.
The Bharatiya Janata Party had last Sunday suspended its national spokesperson Nupur Sharma and expelled its Delhi media head Naveen Kumar Jindal after their controversial remarks against Prophet Mohammad.
Protests erupted in several parts of India on Friday against the controversial remarks on Prophet Mohammad, leaving two persons dead and a few policemen injured in stone-pelting while security forces had to resort to lathi-charge, tear gas shelling and firing in the air at some places.
Asked about Qatar and other countries' reaction to the controversial remarks and the opinion in India being divided, Ansari said it is not fair to say that those who gave these statements about the Prophet were "lightweight" as they were functionaries of the ruling party.
"But what is important is that this is not just about one statement. In the last few months, many statements of this nature have been made. In various Dharm Sansads, anti-minority and anti-Muslim hate speeches were given.
"The words may be different, but the government was completely mum and if any action was taken it was very late with no meaning," he told BBC Hindi in an interview.
It's not sudden, it was building up for some time and the government was tolerating it because there is a policy, Ansari claimed.
On whether India should apologize, the former vice president said, "I don't think the Government of India should apologise because in diplomacy there are many mechanisms to deal with differences amongst the countries."
Asked why the prime minister or the foreign minister were silent, he said, "The prime minister, home minister and foreign minister are the people who are expected to speak. But they all are silent."
PM Modi has excellent relationships with the heads of all the Gulf countries but his silence is very meaningful, it's not accidental, he claimed.
"It can be interpreted in two ways. Firstly, it can be said the prime minister does not disapprove of what has been said by the BJP spokesperson or it can also be said that he approves of what has been said," the former vice-president said.


The Freedom 251 smartphone manufacturer Ringing Bells has now announced that it is launching a high-definition television set in the market. The company is holding an event in Delhi on July 7 where it is set to launch the Freedom HD LED TV. Alongside, Ringing Bells says it will will also be unveiling new ‘range’ of smartphones at the event.
Ringing Bells has sent out media invites for the event, however no pricing and availability details have been revealed. If the Freedom 251 smartphone is to be any testimony, the HD LED TV will also be ultra-cheap. The company’s general manager Anmol Goel had earlier mentioned that the TV would be less than Rs. 10,000. Presumably, the company will take pre-orders before beginning to ship the product to the buyers. The high definition LED TV is expected to sport a 32-inch display, but there may be other variants as well.
As for unveiling a new range of smartphones, this news comes as a surprise as the company has not managed to deliver its Freedom 251 smartphone to the buyers yet. The invite also claims that the company’s Managing Director Mohit Goel will update the media on developments related to the Freedom 251 smartphone.
With the vision to put a smartphone in every Indian’s hands, the world’s cheapest smartphone Freedom 251 was launched in February. The Noida-based startup is making headlines since then for its inability to handle volume pre-bookings, and delivering handsets on time. Ringing Bells was to begin delivering handsets on June 30, but was delayed to July 6.


text:
Daly City is the largest city in San Mateo County, California, United States, with an estimated .... The racial makeup of Daly City was 56,267 (55.6%) Asian, 23,842 (23.6%) White, 3,600 (3.6%) African American, 805 .... International Airport is nine miles south-east of Daly City; both are easily accessible by freeway or BART.
2 reviews of East Asia Chinese Academy "EACA is one of the best Mandarin learning after school programs we ... Millbrae, CA 94030 ... Lian C. Daly City, CA.
The California Asia Business Council helps California firms of all sizes develop or expand their commercial ties with the economies of Southeast Asia and China ...
Mar 22, 2012 ... Daly City was also the most Asian mainland city in the 2000 census at ... United States, with California claiming the biggest Asian population.
Daly City: City, San Mateo county, California, U.S. Daly City is adjacent to San Francisco, between the San Bruno Mountains and the Pacific Ocean on the San ...
Daly City is a General Law City (authority is set forth in the California ... The Oakland International Airport (OAK) is located about 26 miles to the east and has 12 .... Shopping Centers: Serving Daly City's large and diverse Asian community, ...
932 results ... Find 932 listings related to Asian Massage Services in Daly City on YP.com. See reviews, photos, directions, phone numbers and more for the best ...
Dairy Queen/Orange Julius Treat Ctr of Daly City, CA. We are located at Serramonte Center 66 Serramonte Ctr, Space 821.
Best Chinese Restaurants in Daly City, California: Find TripAdvisor traveler reviews of Daly City Chinese restaurants and search by price, location, and more. ... Eastern European. (7). Egyptian. (2). Ethiopian .... Chinese Asian. “Happy Hour ...

domain: geography


A Westcliff nursing home has released a statement following the death of a elderly woman in their care and the start of a murder investigation.
Today (Tuesday December 11), forensic officers were seen at Langley Lodge Nursing Home, on Imperial Avenue in Westcliff.
At around 10pm last night (Monday, December 10) police were called to the home with reports that a woman, aged in her 70s, had died of her injuries.
A 52-year-old man, from Leigh-on-Sea, was arrested at the scene and remains in custody for questioning.
A post-mortem investigation will be carried out in due course.
Essex Police has confirmed that they are not looking for any other suspects in relation to the death of the woman.
A force spokesperson also revealed that the suspect was related to the woman.
A spokesman from the Nursing Home said: "Langley Lodge Nursing Home can confirm that an incident took place yesterday.
"We are utterly shocked by what happened and we are cooperating with the police on this matter.
"We are providing support to other residents and their families. We will not comment further at this time."


Five piece Michigan rock-pop band release their latest; War of Angels. Pop Evil is one of the many bands that will always confuse and concern me. You see Pop evil consists of musicians, “real” musicians, and I don’t mean that in a, “Whoa dude, you’re real” way, but in the sense that they know how to play their instruments, write catchy songs, and a vocal range is present with front man Leigh Katkaty. However this all gets horrifically lost in the midst of slimey record producers and the mass media who have lost their brain cells to microwaves and the primitive sound quality on Rock Band. All that being said, this album blows, this band blows, their music videos especially blow and it’s too bad because a sense of musicianship is somewhere in there, drowned in Slash nostalgic guitar riffs and octaves that should be saved exclusively for blowjob groans.
The talent is prevalent in the song “Monsters You Made” which is slightly more subtle lyrically and compassionate in subject matter, this deserves respect no matter what. “Next Life” contains some serious guitar licks as does “I’ll Do Better Next Time” which also contains sincerity.
For the most part “War of Angels” is a long session of obnoxious and repetitive lyrics that plant an ear parasite. Over that you have too cool for school power chords lost in a drum machine. If Linkin Park, Nickelback and Seether had some disgusting threesome this album would be it’s groaning love child.


text:
The interim aged care royal commission report makes clear that a dramatic increase in funding is going to be needed to give Australia an aged care system that doesn't make us ashamed. But it's also clear such an increase isn't going to be enough. The aged care crisis -- and nothing short of that term is sufficient -- is a frighteningly complex policy problem and one that's not going to be fixed quickly.
If you haven't read the foreword to the commission's interim report, go and do so right now. It's harrowing and shameful. It's unsurprising the government was taken aback by the scale of neglect, abuse and mistreatment that is being meted out to elderly Australians, and the blunt language the report -- bearing the imprint of the late Richard Tracey -- uses to convey it.

domain: politics


text:
Who can enter? The contest is only for our members of Mega Mailer Club, Gas Bucks, and Mega Gas Bucks. Each member has an opportunity to earn MULTIPLE TICKETS into the drawing.
How do you enter? Members can earn a ticket with each personal sale from any of our flyers. The more sales you have the more chances for us to pull YOUR NAME out of the hat!
Make 1 sale = 1 ticket into the drawing.
Make 2 sales = 2 tickets into the drawing.
Make 3 sales = 3 tickets into the drawing.
Make 5 sales = 5 tickets into the drawing.
Make 10 sales = 10 tickets into the drawing.
Make 15 sales = 15 tickets into the drawing.
And so on, and so on... we get the point!
***The last entry for the contest can be entered up until 7:00 pm est on contest drawing day!
When is the drawing? October 7th, 2022 @ 9 pm EST
Where can I watch the live drawing? Over at our MEGA MAILER Club Facebook Page.
Then what are you waiting for??!! We have 3 flyer options here on our website. Join a flyer and start earning today. All we do is share a great idea. Better yet ~ Find a member and join them! It's more fun with friends! Questions? Click the button below and ask away.
Get 10% off your first purchase when you sign up for our newsletter!


text:
My coworkers have been better than me at writing blog articles about OpenIG (at least faster).
Here are a few links :
Simon Moffat describes the benefits of OAuth2.0 and OpenID Connect and how to start using those with OpenIG 3.0.
Warren Strange went a little bit further and with a short introduction to OpenIG, made available on GitHub sample configuration files for OpenIG 3.0 to start using OpenID Connect.
Mark, who run ForgeRock documentation team, describes the improvements done on the Introduction section of the OpenIG docs that we’re making based on received feedback since the release of OpenIG 3.0.

domain: library


text:
- 1 What are NC most common sources of drinking water?
- 2 Does North Carolina have good tap water?
- 3 How close is New Bern NC to the ocean?
- 4 Where does Lexington NC get its drinking water?
- 5 Why is NC considered to have a good water supply?
- 6 What is the number one water pollutant in NC?
- 7 How safe is North Carolina water?
- 8 Is Raleigh tap water good?
- 9 Is it safe to drink Charlotte tap water?
- 10 Are there alligators in New Bern NC?
- 11 What is the crime rate in New Bern North Carolina?
- 12 What is the nearest beach to New Bern NC?
- 13 What water source does most of the tap water come from in Davidson County NC?
- 14 Where does Davidson County water come from?
- 15 Is Davidson County water safe to drink?
What are NC most common sources of drinking water?
In most cases, drinking water comes from two sources: surface water or ground water.
Does North Carolina have good tap water?
Raleigh’s tap water is perfectly safe to drink and, according to the North Carolina American Water Works Association, one of the “best tasting” in North Carolina.
How close is New Bern NC to the ocean?
There are 33.12 miles from New Bern to Atlantic Beach in southeast direction and 41 miles (65.98 kilometers) by car, following the US-70 E route. New Bern and Atlantic Beach are 58 minutes far apart, if you drive non-stop. This is the fastest route from New Bern, NC to Atlantic Beach, NC.
Where does Lexington NC get its drinking water?
In emergencies, the City has two emergency supplies: City Lake, which contains about 150 million gallons of water, and several interconnections with Davidson Water, Inc. Water must be pumped from City Lake to Lexington’s Water Plants.
Why is NC considered to have a good water supply?
underground water resources, North Carolina has historically been considered a water-rich state. In recent years, however, the state has faced water short ages due to a combination of rapid population growth, drought, and aquifer degradation.
What is the number one water pollutant in NC?
EPA detected PFAS in the drinking water of 20 public water systems, across 11 counties in North Carolina. These man-made chemicals are found in consumer products as varied as nonstick cookware, pizza boxes, and stain repellants. They do not break down, so PFAS can accumulate in the environment over time.
How safe is North Carolina water?
North Carolinians are consistently served a safe, reliable supply of drinking water by compliant water systems.
Is Raleigh tap water good?
Though Raleigh’s water quality is in compliance with federal regulations, the EPA and CDC have both acknowledged that there is no safe level of lead, and federal regulations do not take into account levels measured at an individual tap.
Is it safe to drink Charlotte tap water?
It’s safe and reliable, city says. A report Wednesday on the health of the nation’s drinking water says Charlotte’s water contains chemicals that could make consumers sick. They form when chlorine used to disinfect drinking water reacts with natural organic matter in warm weather.
Are there alligators in New Bern NC?
NEW BERN, Craven County — City leaders in New Bern are telling residents to beware of alligators. The warning stems from growing reports of alligator sightings in rivers, lakes, streams, and back yards.
What is the crime rate in New Bern North Carolina?
In 2019, the City of New Bern had a violent crime rate of 401.47 per 100,000 people. This is a 3.32% decrease from 2018, when the rate was 415.27. There were 121 violent offenses reported this year, showing a decrease from 125 in 2018. Violent crime includes Homicide, Rape, Robbery, and Aggravated Assault.
What is the nearest beach to New Bern NC?
The Best 10 Beaches in New Bern, NC
- Neuse River Recreation. 10.8 mi.
- Emerald Isle Beach Access. 30.7 mi.
- Atlantic Beach at Fort Macon. 30.8 mi.
- Salter Path Beach Access. 30.3 mi.
- Shackleford Wild Horse and Shelling Safari. 35.1 mi.
- Cape Lookout National Seashore. 41.9 mi.
- Onslow Beach. 38.4 mi.
- Crystal Coast Ecotours. 28.9 mi.
What water source does most of the tap water come from in Davidson County NC?
The Yadkin River is one of Davidson County’s most valuable assets, serving as the County’s primary drinking water source.
Where does Davidson County water come from?
Sources Of Drinking Water in Davidson County, Tennessee Davidson County’s drinking water comes from the Cumberland River, which is treated at both the K.R. Harrington and Omohundro water filtration plants. The Cumberland River has historically been plagued with industrial pollution.
Is Davidson County water safe to drink?
We are proud to again report that your drinking water exceeds all federal and state standards and is safe to drink.


Exerpt from a Simon Pegg Interview about the story and explosions and ****.
What you have to maintain with Star Trek is that it’s rooted somewhere in our universe. In humanity, [compared to Star Wars, which] is a long time ago in a galaxy far, far away.
The thing that makes that Star Wars more science fantasy is there’s a lot of special effects, a lot of fighting. Star Trek never could afford that, in a way. Which is why it had to concentrate on other aspects of production. We can do both now now. So I think it’s kind of finding a way of having that really fun, spectacular event cinema, but grounding it.
Because explosions don’t mean a damn thing if you don’t care about who’s involved in the explosions. You can see that most incredible fireworks on a cinema screen. But if you don’t fundamentally care about the people that are in jeopardy then they’re so unimpressive. You see that time and time again these days."
"I felt like now it was time to move away from the [Kirk-Spock] bromance thing and concentrate on the idea of the crew as a family living in a small space together, and what it means to all of them. I really love the dynamic between Bones and Spock, so that’s something we’ve kind of concentrated on a little bit with this one.
Kirk’s older than his dad was when he died. All that sort of psychological stuff is playing on him. Scotty’s just still Scotty."
The crew is 2 years into the 5 year mission...
"[The crew knows] that they’ve still got time to go. It’s more that they’re dealing with what would inevitably be the psychological impact of doing it. It’s not they’re, “Oh, I don’t want to do this anymore.” No one’s over it. It’s just that they’re doing their job. They’re going from adventure to adventure and it’s kind of tiring, and wondering what the end game of it all is.
The idea of the movie, the story in the film, is that what they encounter helps to clarify what their job is."


text:
Filmed just in one morning at the famous Bristol Bay Lodge in Alaska.
For more information check out all our destinations in Christmas Island at
Hope you enjoy the film and please remember to leave your comments,
ALL COMMENTS WELCOME
For further information on this or any of our holidays, please contact us on firstname.lastname@example.org or call us on 0044 (0) 1603 407596
Also check out our other videos on Alaska and other destinations.
Salmon Fly Fishing Alaska Episode 2
Salmon Fly Fishing Alaska Episode 3
Alaska Fly Fishing – Rainbow Trout (1080p HD)
Fly Fishing For GT’s On Christmas Island
GT Fishing Christmas Island, real adrenaline fueled fun non-stop action
Bonefish Fishing Christmas Island, stunning flats and non stop action.
Mahseer Fishing On The Cauvery River 130lb WORLD RECORD
Check out our website

domain: entertainment


text:
Heterobifunctional chimeric degraders are a class of ligands that recruit target proteins to E3 ubiquitin ligases to drive compound-dependent protein degradation. Advancing from initial chemical tools, protein degraders represent a mechanism of growing interest in drug discovery. Critical to the mechanism of action is the formation of a ternary complex between the target, degrader and E3 ligase to promote ubiquitination and subsequent degradation. However, limited insights into ternary complex structures exist, including a near absence of studies on one of the most widely co-opted E3s, cellular inhibitor of apoptosis 1 (cIAP1). In this work, we use a combination of biochemical, biophysical and structural studies to characterize degrader-mediated ternary complexes of Bruton’s tyrosine kinase and cIAP1. Our results reveal new insights from unique ternary complex structures and show that increased ternary complex stability or rigidity need not always correlate with increased degradation efficiency.
Subscribe to Journal
Get full journal access for 1 year
only $4.92 per issue
All prices are NET prices.
VAT will be added later in the checkout.
Tax calculation will be finalised during checkout.
Rent or Buy article
Get time limited or full article access on ReadCube.
All prices are NET prices.
Structural coordinates from X-ray crystallography experiments have been deposited at RCSB with the following accession codes: 6W74 (cIAP1–BC5P binary structure), 6W7O (BTK–BCPyr–cIAP1 ternary structure) and 6W8I (BTK–BC5P–cIAP1 ternary structure). NMR data have been deposited to the Biological Magnetic Resonance Data Bank. Source data are provided with this paper.
Sakamoto, K. M. et al. Protacs: chimeric molecules that target proteins to the Skp1–cullin–F box complex for ubiquitination and degradation. Proc. Natl Acad. Sci. USA 98, 8554–8559 (2001).
Ohoka, N. et al. In vivo knockdown of pathogenic proteins via specific and nongenetic inhibitor of apoptosis protein (IAP)-dependent protein erasers (SNIPERs). J. Biol. Chem. 292, 4556–4570 (2017).
Bondeson, D. P. et al. Catalytic in vivo protein knockdown by small-molecule PROTACs. Nat. Chem. Biol. 11, 611–617 (2015).
Sun, X. et al. A chemical approach for global protein knockdown from mice to non-human primates. Cell Discov. 5, 10 (2019).
Schneekloth, A. R., Pucheault, M., Tae, H. S. & Crews, C. M. Targeted intracellular protein degradation induced by a small molecule: en route to chemical proteomics. Bioorg. Med. Chem. Lett. 18, 5904–5908 (2008).
Mullard, A. First targeted protein degrader hits the clinic. Nat. Rev. Drug Discov. 18, 237–239 (2019).
Schapira, M., Calabrese, M. F., Bullock, A. N. & Crews, C. M. Targeted protein degradation: expanding the toolbox. Nat. Rev. Drug Discov. 18, 949–963 (2019).
Lu, J. et al. Hijacking the E3 ubiquitin ligase cereblon to efficiently target BRD4. Chem. Biol. 22, 755–763 (2015).
Nowak, R. P. et al. Plasticity in binding confers selectivity in ligand-induced protein degradation. Nat. Chem. Biol. 14, 706–714 (2018).
Zorba, A. et al. Delineating the role of cooperativity in the design of potent PROTACs for BTK. Proc. Natl Acad. Sci. USA 115, E7285–E7292 (2018).
Winter, G. E. et al. Phthalimide conjugation as a strategy for in vivo target protein degradation. Science 348, 1376–1381 (2015).
Farnaby, W. et al. BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design. Nat. Chem. Biol. 15, 672–680 (2019).
Gadd, M. S. et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat. Chem. Biol. 13, 514–521 (2017).
Min, J.-H. et al. Structure of an HIF-1α–pVHL complex: hydroxyproline recognition in signaling. Science 296, 1886–1889 (2002).
Zoppi, V. et al. Iterative design and optimization of initially inactive proteolysis targeting chimeras (PROTACs) identify VZ185 as a potent, fast, and selective von Hippel–Lindau (VHL) based dual degrader probe of BRD9 and BRD7. J. Med. Chem. 62, 699–726 (2019).
Peng, Y. et al. Bivalent Smac mimetics with a diazabicyclic core as highly potent antagonists of XIAP and cIAP1/2 and novel anticancer agents. J. Med. Chem. 55, 106–114 (2012).
Sun, H., Lu, J., Liu, L., Yang, C.-Y. & Wang, S. Potent and selective small-molecule inhibitors of cIAP1/2 proteins reveal that the binding of Smac mimetics to XIAP BIR3 is not required for their effective induction of cell death in tumor cells. ACS Chem. Biol. 9, 994–1002 (2014).
Varfolomeev, E. et al. IAP antagonists induce autoubiquitination of c-IAPs, NF-κB activation, and TNFα-dependent apoptosis. Cell 131, 669–681 (2007).
Chessari, G. et al. Fragment-based drug discovery targeting inhibitor of apoptosis proteins: discovery of a non-alanine lead series with dual activity against cIAP1 and XIAP. J. Med. Chem. 58, 6574–6588 (2015).
Tamanini, E. et al. Discovery of a potent nonpeptidomimetic, small-molecule antagonist of cellular inhibitor of apoptosis protein 1 (cIAP1) and X-linked inhibitor of apoptosis protein (XIAP). J. Med. Chem. 60, 4611–4625 (2017).
Sun, H. et al. Nonpeptidic and potent small-molecule inhibitors of cIAP-1/2 and XIAP proteins. J. Med. Chem. 53, 6361–6367 (2010).
Ohoka, N. et al. Derivatization of inhibitor of apoptosis protein (IAP) ligands yields improved inducers of estrogen receptor α degradation. J. Biol. Chem. 293, 6776–6790 (2018).
Okuhira, K. et al. Specific degradation of CRABP-II via cIAP1-mediated ubiquitylation induced by hybrid molecules that crosslink cIAP1 and the target protein. FEBS Lett. 585, 1147–1152 (2011).
Itoh, Y., Ishikawa, M., Naito, M. & Hashimoto, Y. Protein knockdown using methyl bestatin–ligand hybrid molecules: design and synthesis of inducers of ubiquitination-mediated degradation of cellular retinoic acid-binding proteins. J. Am. Chem. Soc. 132, 5820–5826 (2010).
Itoh, Y. et al. Development of target protein-selective degradation inducer for protein knockdown. Bioorg. Med. Chem. 19, 3229–3241 (2011).
Itoh, Y., Kitaguchi, R., Ishikawa, M., Naito, M. & Hashimoto, Y. Design, synthesis and biological evaluation of nuclear receptor-degradation inducers. Bioorg. Med. Chem. 19, 6768–6778 (2011).
Demizu, Y. et al. Design and synthesis of estrogen receptor degradation inducer based on a protein knockdown strategy. Bioorg. Med. Chem. Lett. 22, 1793–1796 (2012).
Tinworth, C. P. et al. PROTAC-mediated degradation of Bruton’s tyrosine kinase is inhibited by covalent binding. ACS Chem. Biol. 14, 342–347 (2019).
Casillas, L. N., Harling, J. D. M., Afjal H., Smith, I. E. D. & Rackham, M. D. Preparation of PROTAC compounds conjugates comprising RIPK2 inhibitors, especially IAP binder linked RIPK2 inhibitors, for treating inflammations. International patent WO2017182418 A1 (2017).
Shibata, N. et al. Development of protein degradation inducers of oncogenic BCR–ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 108, 1657–1666 (2017).
Huang, H.-T. et al. A chemoproteomic approach to query the degradable kinome using a multi-kinase degrader. Cell Chem. Biol. 25, 88–99 (2018).
Byrd, J. C. et al. Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia. N. Engl. J. Med. 369, 32–42 (2013).
Wang, M. L. et al. Targeting BTK with ibrutinib in relapsed or refractory mantle-cell lymphoma. N. Engl. J. Med. 369, 507–516 (2013).
Pan, Z. et al. Discovery of selective irreversible inhibitors for Bruton’s tyrosine kinase. ChemMedChem 2, 58–61 (2007).
Honigberg, L. A. et al. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc. Natl Acad. Sci. USA 107, 13075–13080 (2010).
Buhimschi, A. D. et al. Targeting the C481S ibrutinib-resistance mutation in Bruton’s tyrosine kinase using PROTAC-mediated degradation. Biochemistry 57, 3564–3575 (2018).
Woyach, J. A. et al. Resistance mechanisms for the Bruton’s tyrosine kinase inhibitor ibrutinib. N. Engl. J. Med. 370, 2286–2294 (2014).
Sun, Y. et al. PROTAC-induced BTK degradation as a novel therapy for mutated BTK C481S induced ibrutinib-resistant B-cell malignancies. Cell Res. 28, 779–781 (2018).
Borzilleri, R. M. P. et al. Preparation of peptide IAP antagonists for cancer treatment. International patent WO2014047024A1 (2013).
Feltham, R. et al. Smac mimetics activate the E3 ligase activity of cIAP1 protein by promoting RING domain dimerization. J. Biol. Chem. 286, 17015–17028 (2011).
Horst, R., Horwich, A. L. & Wüthrich, K. Translational diffusion of macromolecular assemblies measured using transverse-relaxation-optimized pulsed field gradient NMR. J. Am. Chem. Soc. 133, 16354–16357 (2011).
Sekine, K. et al. Small molecules destabilize cIAP1 by activating auto-ubiquitylation. J. Biol. Chem. 283, 8961–8968 (2008).
Dueber, E. C. et al. Antagonists induce a conformational change in cIAP1 that promotes autoubiquitination. Science 334, 376–380 (2011).
Lopez, J. et al. CARD-mediated autoinhibition of cIAP1’s E3 ligase activity suppresses cell proliferation and migration. Mol. Cell 42, 569–583 (2011).
Ciulli, A., Testa, A., Hughes, S. J., Lucas, X. & Wright, J. E. Structure-based design of a macrocyclic PROTAC. Angew. Chem. Int. Ed. Engl. https://doi.org/10.1002/anie.201914396 (2019).
Duda, D. M. et al. Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation. Cell 134, 995–1006 (2008).
Baek, K. et al. NEDD8 nucleates a multivalent cullin–RING–UBE2D ubiquitin ligation assembly. Nature 578, 461–466 (2020).
Mares, A. et al. Extended pharmacodynamic responses observed upon PROTAC-mediated degradation of RIPK2. Commun. Biol. 3, 140 (2020).
Zhang, X. et al. Discovery of IAP-recruiting BCL-XL PROTACs as potent degraders across multiple cancer cell lines. Eur. J. Med. Chem. 199, 112397 (2020).
McCoy, A. J. et al. Phaser crystallographic software. J. Appl. Crystallogr. 40, 658–674 (2007).
Condon, S. M. et al. Birinapant, a Smac-mimetic with improved tolerability for the treatment of solid tumors and hematological malignancies. J. Med. Chem. 57, 3666–3677 (2014).
Bender, A. T. et al. Ability of Bruton’s tyrosine kinase inhibitors to sequester Y551 and prevent phosphorylation determines potency for inhibition of Fc receptor but not B-cell receptor signaling. Mol. Pharmacol. 91, 208 (2017).
Blanc, E. et al. Refinement of severely incomplete structures with maximum likelihood in BUSTER-TNT. Acta Crystallogr. D Biol. Crystallogr. 60, 2210–2221 (2004).
Emsley, P. & Cowtan, K. Coot: model-building tools for molecular graphics. Acta Crystallogr. D Biol. Crystallogr. 60, 2126–2132 (2004).
Drummond, M. L. & Williams, C. I. In silico modeling of PROTAC-mediated ternary complexes: validation and application. J. Chem. Inf. Model. 59, 1634–1644 (2019).
Harder, E. et al. OPLS3: a force field providing broad coverage of drug-like small molecules and proteins. J. Chem. Theory Comput. 12, 281–296 (2016).
Watts, K. S. et al. ConfGen: a conformational search method for efficient generation of bioactive conformers. J. Chem. Inf. Model. 50, 534–546 (2010).
Bax, A. & Grzesiek, S. Methodological advances in protein NMR. Acc. Chem. Res. 26, 131–138 (1993).
Bartels, C., Xia, T.-H, Billeter, M., Güntert, P. & Wüthrich, K. The program XEASY for computer-supported NMR spectral analysis of biological macromolecules. J. Biomol. NMR 6, 1–10 (1995).
Keller, R. Optimizing the Process of Nuclear Magnetic Resonance Spectrum Analysis and Computer Aided Resonance Assignment PhD thesis, ETH Zurich (2005).
We thank K. Fennell and P. Montanaro for expression of [15N13C]cIAP1Bir3 used in the pilot NMR experiments, J. Chang for the protein purification schemes of cIAP1Bir3 and biotinylated BTKKD and L. Byrnes and A. Varghese for SEC MALS troubleshooting and analysis. We also thank J. Knafels for crystal preparation before synchrotron shipment and J. Smith for the THP-1 cell culture and degradation protocols. BC5P synthesis was assisted by A. Davies. Compounds BC2P and BCPyr were synthesized by Wuxi PharmaTech. We also thank K. Farley, A. Ratnayake and T. Ryder for assistance with small-molecule NMR analysis. All individuals named are current or former members of Pfizer Worldwide Research and Development, Groton CT, USA.
All authors are current or former employees of Pfizer, Inc.
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
a, Two representative replicate experiments (top and bottom) of dose dependent BTK degradation in THP1 cells and associated DC50 curve-fit. b, Schematic representation of 2-PEG ‘BC2P’ (2), with regions corresponding to BTK ligand (magenta), linker (black) and cIAP1 ligand (blue) indicated. c, Western blot analysis of dose dependent BTK degradation in THP1 cells by BC5P (left), BC2P (right) and associated DC50 curve-fit. The experiment was repeated for a total of 3 independent experiments with reproducible findings (d) Rescue of BC5P dependent degradation using a BTK ligand, and corresponding vinculin loading control with densiometric quantification shown on the left. The experiment was repeated for a total of 5 independent experiments with reproducible findings. Filled circles and hollow triangles represent untreated or BTK ligand treated samples, respectively. Error bars represent ± 1 standard deviation and these data are a result of n=5 independent experiments. Statistical analysis was performed using a two-sided student’s unpaired T Test where significance (*) a p value of 0.022 and 0.033 for 2.5 μM and 0.083 μM treatments, respectively.
Electron density difference map examining ternary complex Pose 2, with BC5P. Anisotropic data (left), and isotropic data (right) with 2Fo-Fc σ = 1.0.
a, Overlay of [15N,1H]-COSY spectra with15N13C cIAP1Bir3 as either apo (red) or an IAP-ligand binary complex (blue). b, [15N,1H]-HSQC spectrum of uniformly 15N,13C-enriched cIAP1Bir3 in complex with the IAP-ligand. Backbone resonance assignments are indicated by the one-letter amino acid code and the sequence number. The backbone cross-peaks of G46 and C62 are outside of the region shown. c, TRO-STE spectra of cIAP1Bir3/BC5P/BTKKD. The relative signal intensity ln(S/So) is plotted versus the square of the field gradient strength, \(G_D^2\). Green triangles and black squares represent data for the apo form of cIAP1Bir3 and for the cIAP1Bir3/BC5P/BTKKD ternary complex, respectively. Translational diffusion coefficients, Dt, as calculated from the diffusion data are indicated.
a, Electron density difference map examining the binary crystal structure of cIAP1Bir3 and BC5P. Density substantially weakens over the benzyl portion of the tetrahydroisoquinoline, thus preventing further modeling of the linker. Protein is omitted on the right panel for clarity. b, Protein-Ligand interactions between BC5P and cIAP1Bir3 in the binary crystal structure. Dashed lines indicate a set of polar interactions ≤ 3.5 Å in length.
a, Western blot image of in vitro ubiquitination of BTKKD by cIAP1BUCR1 in the presence of BC5P, or BCPyr. Quantification of mUb and pUb signal was done using ImageJ analysis (v220.127.116.11). b, Ternary complex assay sensorgram of a binary [cIAP1Bir3-BC5P] complex binding to BTKKD, and (c) [cIAP1Bir3-BCPyr] complex binding to BTKKD. For panel B, data was fit globally (left) or independently for Kon and Koff (right) yielding consistent affinity values.
Electron density for the BTKKD/BCPyr/cIAP1Bir3 ternary complex structure covering a portion of the protein-protein interface (proximal to BTKKD R487). Left and middle panels show map (2Fo-Fc contoured at σ = 1.0) for the two copies in the asymmetric unit. Panel on the right shows an overlay of the two copies with density omitted. R487 sidechain is modeled in different conformations in the two copies, projecting toward either one or both aspartic acids presented by cIAP1.
a, Top panel: Crystallographic pose of BTKKD (gray), cIAP1Bir3 (orange), and BCPyr (light orange). Bottom panel: Linker substitution modeled to generate Piperidine ‘BCPip’ (4) (purple). b, Schematic representation of BCPip, with regions corresponding to BTK ligand (Magenta), linker (Black) and IAP ligand (Blue) indicated. c, Ternary complex assay sensorgram of a binary [cIAP1BUCR1-BCPip] complex binding to BTKKD. d, Western blot analysis of dose dependent BTK degradation in THP1 cells by BCPip and associated DC50 curve-fit.
a, Native ESI Mass spectrometry showing the spectrum for monomeric cIAP1BUCR1 (Top Panel) or a spectrum for cIAP1BUCR1/ BC5P (Bottom Panel). A Distinct M/Z shift between cIAP1BUCR1 monomer (+) and cIAP1BUCR1 monomer after BC5P (‡) treatment is indicative of a single molecule of BC5P binding to the monomer. The dimer fraction (#) is comprised of 2 molecules of BC5P bound to 2 molecules of cIAP1BUCR1. These data demonstrate a 1:1 or 2:2 stoichiometry of BC5P for cIAP1BUCR1. b, Size Exclusion Chromatography Multi-Angle Light Scattering (SEC MALS) chromatograph of a cIAP1BUCR1/BC5P dimer (red), a lower concentration intermediate (blue), and a DMSO treated cIAP1BUCR1 monomer (black). Calculated molecular weights are shown as squares, change in refractive index (dRI) is shown as dotted lines, light scattering (LS) is shown as solid lines, and expected molecular weights are shown as dashed light blue lines. c, SEC MALS chromatograph of a cIAP1BUCR1/BCPyr dimer (red), and a cIAP1BUCR1/BCPyr/BTKKD dimer of ternary complexes (purple). Calculated molecular weights shown as squares, change in refractive index (dRI) is shown as dotted lines, light scattering (LS) is shown as solid lines, and expected molecular weights are shown as dashed light blue lines. This experiment was performed 3 times with reproducible results.
About this article
Cite this article
Schiemer, J., Horst, R., Meng, Y. et al. Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes. Nat Chem Biol 17, 152–160 (2021). https://doi.org/10.1038/s41589-020-00686-2
Proteolysis targeting chimeras (PROTACs) come of age: entering the third decade of targeted protein degradation
RSC Chemical Biology (2021)
Drug Discovery Today: Technologies (2020)

domain: chemistry


Rafa Benitez had given a long interview in the Chronicle today, and he admits that the importance of the FSA Cup has diminished over the last several years because of the massive money to be made by being a Premier League club.
Clubs in the Premier League will concentrate on staying there at the expense of the FA Cup.
It’s all about money of course and if Newcastle are relegated we lose at least £100M during the next year.
Rafa has talked about how football is all about money these days, and therefore he has to see what kind of team he will field in each round of the FA Cup.
Rafa Benitez – it’s all about money
Rafa will take the FA Cup one round at a time.
But for today’s game at home to Luton Town there’s no reason Rafa cannot field a strong side since our next league game is next Saturday at home to Swansea.
Rafa was asked in the Chronicle today if the Premier League’s big money has relegated the importance of the FA Cup:
“I remember when I was at Liverpool, we had to win the league and now at any top side, some of them it’s just to stay in the top four.”
“Why? Because you have the Champions League money, so everything is around money.”
“If you have more money, you can buy better players, you can play better football, so it’s always the same situation.”
“The question is that Newcastle United Football Club is a massive club, but now we are newly promoted.”
“And just here in the Premier League with massive problems because we have to stay up.”
“That is the priority and the money is so big now that if you don’t stay in the Premier League, you lose £100M already.”
“We have to stay in the Premier League, but at the same time, we will try to win against Luton.”
“I don’t like to lose any game, but if you lose in a cup competition, it’s always worse because you have a bad feeling after.”
“In the league, you have an opportunity to change it, but in the cup, you cannot. Obviously, it’s a bad feeling.”
“Yeah I understand the fans’ frustration at Newcastle’s FA Cup record, but at the same time, every year is different.”
“So we have to be realistic and it’s not the same Newcastle United as even five years ago as it is now.”
“But we will try to win this game and then see where we are in the future.”
One reason Newcastle must win is that would take our winning streak up to two.
And then hopefully we can make it three wins in a row next Saturday in a crucial relegation encounter with Swansea City.
We must win that game, and if we cannot get all 3 points, we cannot lose it and let Swansea gain 3 points on us.
We were hoping to have a new striker in by then – but that doesn’t look likely now.


text:
Wisconsin Energy is considering converting its coal-fired Valley Power Plant in Milwaukee to gas-fired generation, CEO Gale Klappa told shareholders during the company’s annual meeting Thursday in Mequon, WI.
Articles from Milwaukee
Recession-driven sales declines, particularly among large commercial and industrial customers, are affecting combination Milwaukee-based utility Wisconsin Energy (WE), but the company nevertheless reported increased profits for the first quarter compared to the same period in 2008.
Fuel costs, particularly the level and volatility of wholesale natural gas prices, cut into robust first quarter results for Milwaukee-based Wisconsin Energy, following record electricity and natural gas retail utility consumption in the winter quarter, the utility reported Tuesday.
Milwaukee-based Wisconsin Energy Corp. (WEC) is relying on its core gas and electric utility divisions to pull it through, while the company continues to take its lumps in asset sales and its non-utility energy business.
Milwaukee-based We Energies (formerly Wisconsin Energy Corp.) is delaying construction of a 38-mile natural gas lateral extension into the Guardian pipeline project until the spring of 2003, but Guardian will remain on schedule for an in-service date later this year, a spokeswoman said. We Energies is halting construction of the lateral through Jefferson and Waukesha counties until next year to resolve some permit and land acquisition issues.
Banking on a growing customer base in the upper Midwest,Milwaukee-based Wisconsin Energy Corp. this week unveiled a broad10-year, $6 billion manifesto to construct new power generationunits, refurbish or replace old facilities, improve itsdistribution system, cut its quarterly common stock dividend by50%, and double its share repurchase program.
The groundwork for an even more concentrated U.S. energyindustry was laid Monday as Wisconsin Energy Corp., a Milwaukee,WI-based electric and gas utility, announced plans to acquireneighboring gas distributor WICOR Inc. for about $1.51 billion incash, stock and debt, creating a major Midwest energy concern andthe 13th largest utility in the nation.


text:
This scarce antiquarian book is a facsimile reprint of the original. Due to its age, it may contain imperfections such as marks, notations, marginalia and flawed pages. Because we believe this work is culturally important, we have made it available as part of our commitment for protecting, preserving, and promoting the world's literature in affordable, high quality, modern editions that are true t...
Paperback: 320 pages
Publisher: Kessinger Publishing, LLC (September 10, 2010)
Product Dimensions: 7.5 x 0.7 x 9.2 inches
Amazon Rank: 9184371
Format: PDF ePub djvu ebook
Download Rew canole juicer pdf at allciajirusio.wordpress.com Here Connected the surprising power of our social networks and how they shape our lives pdf link Earl nightingales the strangest secret Here Elements of algebra pdf link Acts deepening life together
This book is filled with everything from how to organize your paper. The various aspect of writing s...
One River, Many Wells. First of all, it is a truly inspired and wonderful title, and the title repr...
R. M. Patterson is always a great read. Puts you right there with him in his canoe ,camp or cabin. H...

domain: literature


text:
Albert Ernst Carrier-Belleuse was well known for his portraits in terra-cotta and bronze. Auguste Rodin was his apprentice in the 1860’s–70’s. Autumn Lovers is a neo-classical style piece representing the autumn season through imagery like the cornucopia, leaves and grapes.
Albert Ernest Carrier-Belleuse. Autumn Lovers, 1857. Bronze, 24.5 x 13 x 10 inches. Frederik Meijer Gardens & Sculpture Park, Grand Rapids, Michigan. Gift of Fred and Lena Meijer.


Union Bank's fintech ambition: Put VR into the appraisal process
Mortgage lending has a long way to go before most people associate it in any way with virtual reality.
However, that doesn't mean that there are no elements of the business it doesn't have relevance. A case in point: Union Bank is considering applying VR to enable appraisals of high-value homes, potentially saving customers money and shortening the loan-approval process.
"In the future, the appraisal could be done virtually, with the owner or buyer holding up his or her phone when visiting the home to provide all the necessary information," said Paul Appleton, head of resident lending and small business banking at Union Bank, a subsidiary of Japan's MUFG Bank. "Then [it would be] reviewed by a licensed appraiser."
Fannie Mae and Freddie Mac already support automated valuations for mortgages conforming to their lending standards, replacing physical inspections with data that describes the neighborhood and the price range of similar loans. Much of Union Bank's mortgage lending business, however, is in California and up the West Coast, where very high priced homes typically require nonconforming jumbo mortgages.
Using virtual reality would further mortgage lenders' popular goal to make the origination process more efficient for customers. On that front, Union Bank enjoys the benefit of a concentration of financial-technology startups and major technology firms near its headquarters in downtown San Francisco.
"I spend about 10% of my time meeting with different fintechs and established technology companies in San Francisco that can work with Union Bank to build a more digitized mortgage platform," Appleton said.
He added that surveys by Union Bank and others reveal only 40% of borrowers are satisfied with their mortgage experience, and it still takes 35 days on average to complete the process. With millennials, reared on highly automated and fast internet-based services making up an ever-larger portion of homebuyers, Union Bank views technology as offering a competitive edge.
Union Bank has concluded, as have other mortgage lenders, that customers prioritize speed, minimal effort to provide information to the bank and understanding their loans' status. To that end, it perpetually searches for new electronic services it can attach to its loan origination system via application programming interfaces.
With customer consent, for example, it can electronically collect documents such as pay stubs and tax forms that previously had to be mailed or emailed, now only for employees of large companies but coverage is expanding.
"Loan officers tell us it has taken a few days out of the work they’ve typically done upfront," Appleton said. "We see this technology playing out as not replacing loan officers but augmenting them with tools so they can be more efficient and productive, developing their business instead of processing loans."
The bank is working to digitize the credit decision, providing customers with immediate understanding of whether they'll qualify for the loan they're seeking. Building such an ecosystem of fintech-generated services requires significant due diligence, ensuring compliance with information security protocols and an array of regulatory requirements. Appleton said the bank is steadily improving that process and onboarding technology partners more quickly.
Loan officers have seen significant benefits. Sending borrowers a link enables them to go through the application process on their own time, with loan officers only stepping in when needed. And physical marketing is being augmented with digital platforms such as LinkedIn, Redfin and Zillow to generate and maintain realtor relationships.
"We have a team checking those [communications] before they go out. In time we plan to switch over to a text-analytics capability, to do this automatically," Appleton said.
Training to adapt to this new mortgage-loan environment is largely conducted online via multiple technology-driven methods, where loan officers' progress can be monitored.
For example, "we're rolling out a virtual reality training mechanism across the organization whereby you can literally put the phone up to your eye and it delivers virtual training," Appleton said.
The bank's mortgage lending business also operates in Arizona and Nevada and expanded into Illinois a few years ago, but most of its business and 350 branches are in California. Among U.S. banks, Union Bank's mortgage portfolio is sixth largest.
A team analyzes factors such as inventories of homes for sale, prices and sales, to alert front-line staff to the current dynamics of its different markets. "In many markets inventories are still low by historical standards and lower interest rates will help maintain property valuations and sales activity," he said.


Who Can Apply: Students who are Kalamazoo County residents or attend an elementary middle or high school within Kalamazoo County are eligible to apply. Must be recommended by a professional employee in their school system or a swimming instructor and meet academic eligibility standards for participation in athletics as defined by his or her school system (middle school and high schools students only). Must demonstrate financial need.
Submission: The completed application, a recommendation from swimming coach or swimming instructor and verification of income (first page of most recent income tax return) must be submitted to the Kalamazoo Community Foundation.
Deadline: November 30, 2020


text:
Extra-curricular| Science | Languages | Architecture
John Davitt reports on the successful portable digital assistant (PDA) project run by Victoria primary in Feltham, west London, for the past two years.
Proudly utopian, E-topia is a shared online space that aims to show children from different cultures they have common interests. Too idealistic? Sean Dodson reports.
As long as it's spotted early, dyslexia needn't be a big barrier to educational achievement, especially with the variety of help now on offer, says Sally McKeown.


Paedophile who killed nine-year-old schoolgirl Samantha Knight after she left her home in Bondi will walk free within days - despite his brother pleading for the 'monster' to be jailed for life
- Samantha Knight, 9, disappeared from near her Bondi home on August 19, 1986
- Her kidnapping sparked one of the largest searches ever mounted in Australia
- Michael Guider was jailed in 1996 for 60 sex offences against 11 other children
- In 2001 he was charged with Sam's murder but pleaded guilty to manslaughter
- Guider claimed he drugged and molested Sam and she died of a drug overdose
The paedophile who killed Sydney schoolgirl Samantha Knight more than 30 years ago is to be released from jail within days after a judge rejected an application to keep him behind bars.
Justice Richard Button on Tuesday instead imposed a five-year extended supervision order with stringent conditions on 68-year-old Michael Guider.
Guider pleaded guilty in 2002 to the manslaughter of nine-year-old Samantha who went missing after leaving her Bondi home on August 19, 1986. Her body has never been found.
Samantha's mother Tess Knight and several of Guider's other victims as well as his brother Tim had pleaded for the serial child sex offender not to be released.
Ms Knight said outside court she was 'shaking inside' after the decision to release Guider.
'We should all be shocked,' she said. 'He hasn’t demonstrated that he's changed.
Scroll down for video
Paedophile and child killer Michael Guider is set to be freed from prison within days after a judge rejected an application to keep him behind bars. Justice Richard Button instead imposed a five-year extended supervision order with stringent conditions on the 68-year-old
Guider pleaded guilty in 2002 to the manslaughter of nine-year-old Samantha who went missing after leaving her Bondi home on August 19, 1986. Her body has never been found
'So not only hasn't he told us what he did with Samantha's body - and there will be no body to find anymore, it's a long time - but he hasn't given me and my family and Samantha's friends any details of what happened that day.'
Tim Guider had hoped his sibling could be coerced into revealing where Samantha was buried and confessing to further crimes against children.
'This is no normal person,' Mr Guider said. 'He's a monster and he's a danger and the community don't want him out.'
Justice Button said the New South Wales Supreme Court hearing was to assess the risk Guider posed in the future, rather than imposing punishment for his prior offending.
He found that a further period of incarceration would not serve any rehabilitative purpose.
While it could not be said definitively that Guider's sexual interest in children had disappeared, the judge considered he had done all that could be done in terms of rehabilitation in a prison setting.
Three experts, highly experienced in psychology and psychiatry, had all agreed Guider's risk could be reasonably managed under a stringent and lengthy system of supervision within the community, the judge said.
He had taken note of Guider's good behaviour when he was on escorted day leave from jail.
Guider's 17-year jail term has expired, but he was placed on an interim detention order which expires on Thursday.
Samantha Knight's killer, serial paedophile Michael Guider, is pictured clutching a Kodak film packet and developed photographs in 1984, the year he began molesting Samantha. Guider drugged and assaulted his many victims then photographed them in pornographic poses
Samantha's mother Tess Knight had pleaded with the Supreme Court to keep her daughter's killer behind bars. Michael Guider's brother Tim has also fought to keep him locked up
Guider will have to live under 56 conditions including wearing electronic monitoring equipment, providing a weekly schedule of his movements to a department supervising officer (DSO) from Corrective Services NSW and never changing his name.
Unless approved by his DSO, he must not go near day care centres, pre-schools, schools, amusement parks, cinemas, libraries, camping grounds, playgrounds or pools.
The NSW Attorney-General had made an application for a one-year detention order.
When sentenced for Samantha's manslaughter, Guider was already serving time for numerous sex offences against other children between 1980 and 1996.
Guider never publicly expressed any remorse for killing Sam - which he claimed was accidental - and has recently even denied any role in her death.
Samantha's 1986 disappearance from near her mother's home in Sydney's eastern suburbs led to one of the largest searches in Australian history and remained a mystery for 15 years.
Parents across the country changed the way they considered their children's safety as hundreds of thousands of posters were distributed featuring smiling images of the confident little girl.
Michael Guider is pictured here at Long Bay jail visiting his brother Tim on Christmas Day, 1986, four months after after he killed Samantha. Guider's maximum sentence expired on June 6 and the New South Wales Attorney-General unsuccessfully sought to keep him inside
Tim Guider believes his brother would reveal where Samantha was buried if he was put before the NSW Crime Commission. 'I am 100 per cent sure from knowing him and the discussions I've had with psychiatrists and psychologists he will not endure a coercive hearing,' he says
Samantha was one of perhaps scores of children aged two to 16 Guider molested over many years. His usual method of offending was to drug then molest pre-pubescent boys and girls.
Many of his victims were the daughters of mothers he had befriended and he sexually assaulted them during babysitting sessions.
Guider played a 'game' called statues with some victims in which he ordered them to stand still while he exposed himself and touched their genitals; he took thousands of images of the children he violated while they were drugged.
The long-haired gardener claimed some of the mothers knew what he was doing and told a psychologist at least one of them - not Samantha's mother - did not mind.
Samantha Knight, who Guider first molested when she was living with her mother Tess at Manly, was one of perhaps scores of children aged two to 16 he assaulted in the 1980s and 1990s. Many of his victims, including Samantha, were the daughters of mothers he befriended
This is the block of flats in Imperial Avenue, Bondi, where Samantha Knight lived with her mother in 1986 as it is today. Michael Guider had acted as a babysitter for Sam and many other pre-pubescent girls whose mothers he befriended. He assaulted the girls after drugging them
'She was bad,' Guider said of the mother. 'I was screwing her two kids and she asked me to do it to her after I'd been doing it to them.'
Guider was serving a 16-year sentence imposed in 1996 for 60 offences against 11 children when police realised he was responsible for one of Australia's most high-profile unsolved crimes.
He was arrested and charged with Samantha's murder in February 2001 but pleaded guilty to manslaughter under the weight of damning evidence including a confession to his brother Tim, a jailed armed robber.
Guider had first molested Samantha when she was living with her mother Tess at Manly in 1984 and 1985.
He snatched Samantha from near her home in Imperial Avenue, Bondi, after school.
The honey-blonde, green-eyed girl had been seen that afternoon walking the streets in her uniform. Within days Sydney was plastered with 'Find our Sam' posters which described her as intelligent, outgoing and well-spoken.
Michael Guider is pictured in 2002 when he was sentenced to a maximum 17 years for Samantha Knight's manslaughter. He was serving a 16-year sentence imposed in 1996 for 60 offences against 11 children when police realised he was responsible for kidnapping Samantha
Guider later claimed he had drugged Samantha with the sleeping pill Normison and she died of an overdose on his lounge while he went out to the shops.
He eventually told investigators he put Samantha's remains in a dumpster containing landfill at the Royal Sydney Yacht Squadron at Kirribilli on the other side of the harbour.
WHY SAMANTHA KNIGHT COULD BE BURIED AT GORE HILL
Michael Guider first buried Samantha Knight at Kirribilli's Royal Sydney Yacht Squadron, where he was working in 1986 when he killed her.
When her original grave was about to be disturbed in 1988 he was working 5km away at Royal North Shore Hospital, next to Gore Hill Cemetery.
The cemetery is easily accessed but secluded and no burials have taken place there since 1974.
Guider lied saying he had never been to the cemetery then admitted he had taken another of his victims there.
The headstone of a woman called Sarah Knight has been broken and rearranged on an unmarked grave in a corner of the cemetery.
When Guider's brother Tim told him he believed Samantha was buried at Gore Hill Cemetery he began to tremble.
Guider was sentenced in August 2002 to 17 years' prison with a non-parole period of 12 years for manslaughter.
He first became eligible for release in June 2014 when the State Parole Authority refused to let him out and determined he could seek freedom the following year.
Parole was again refused in 2015 at which time the authority decided it would not consider his release again until 2017. Guider did not seek parole in 2017 or 2018.
Tim Guider believes he knows where his brother buried Samantha and that if put before the NSW Crime Commission he would lead detectives to her grave.
He is convinced Samantha's body lies under or near a headstone bearing another Knight's name in a corner of the old Gore Hill Cemetery on Sydney's lower north shore.
Mr Guider told Daily Mail Australia his brother had reluctantly admitted this year to visiting the graveyard with another of his child victims years after Samantha's 1986 disappearance.
He thinks while Michael was working next to the cemetery he moved Samantha's body there and arranged parts of a broken memorial to a long-dead woman named Sarah Knight to mark or point to her grave.
Mr Guider said when he told Michael during a prison visit he 'knew' Samantha was buried at Gore Hill Cemetery the serial paedophile began to tremble and was struck speechless.
Samantha Knight's mother Tess (second from right) was among those who campaigned to keep Michael Guider behind bars. Their bid failed on Tuesday and Guider will be released
WHY MICHAEL GUIDER SHOULD NEVER HAVE BEEN RELEASED
Michael Guider has not revealed where Samantha Knight is buried, continues to pose a risk to children and has never shown any remorse.
Those campaigning to keep the paedophile behind bars also believe he has not served enough time for his earlier crimes against girls and boys, some of whom have never come forward.
The man who knows Guider best - his brother Tim - tried desperately to keep him locked up.
'This is no normal person,' Mr Guider said. 'He's a monster and he's a danger and the community don't want him out.'
Guider was already serving 16 years for child sex offences against more than a dozen victims when he pleaded guilty to Samantha's manslaughter.
Lisa Giles, who was abused by Guider, pleaded for him to be kept in prison when she read a victim impact statement in the Supreme Court last month.
'We are not physically safe if he is released - our children are not safe and our minds are not safe,' Ms Giles told the court.
'This is not a man who will fade into obscurity and potter humbly around his garden.'
'His tentacles have such insidious reach. He's not a one-trick pony and he's not finished yet.'
Ms Giles had waived her right to anonymity after three decades to speak out for the first time in a bid to stop her abuser's release.
'Michael is relying on us all to assume that what's done is done, and he's probably quite smug at his success at avoiding being charged with any further crimes,' she said.
'And there are a lot of us. More of us than those who came forward to make statements, and even more still who could not use their experiences for the purposes of putting him into jail.
'You might have been led to believe that what you experienced was "not that bad" or that there is some kind of trauma hierarchy that you think you are at the bottom of. You are not. Everything counts.'
Samantha's mother Tess told the court she was still haunted by her daughter's last afternoon alive. She wondered if Samantha had said: 'I want my mummy.'
'Did she wonder where I was and why I wasn't there to help her?' she asked.
Ms Knight said Guider showed no remorse for killing her daughter and continued to drug and sexually assault more children after her death.
She had 'imagined thousands and thousands of scenarios, over and over and over again' regarding Samantha's fate.
'Was she so scared that she used the words of a younger child? Did she say "I want my mummy"? Did she tell him "I want to go home"?.'
'Please don't release him into the community until the time comes when we have no choice,' she had asked the judge.
Chantelle Daly, another of Guider's victims, said her abuser being allowed on day release and his classification as a model prisoner were 'the ultimate slap in the face'.
She believed authorities underestimated the threat Guider still posed.
'You're a prisoner for horrific crimes. You're in jail for committing the ultimate evil, you can't be a "model prisoner". It's a disgusting statement,' she said.
Forensic psychiatrist Jonathon Adams had agreed Guider still posed a high risk of re-offending.
He risked relapsing into sexual fantasies and urges if he saw children running around and had access to them, Dr Adams told the court.
Guider had been able to serve sentences for serial sex crimes against children concurrently, rather than one after the other.
He was jailed in 1996 after pleading guilty to 60 child sex offences including sexual intercourse without consent against 11 children - nine girls and two boys.
He was sentenced to a maximum term of 16 years.
In 2000 Guider was charged with eight more child sex offences from the 1980s and sentenced to further terms of six and a half years and 12 months.
Those terms did not increase his maximum sentence.
Then in 2002 he pleaded guilty to killing Samantha and was sentenced to a maximum term of 17 years.
Ms Giles said: 'Had Guider been serving his sentences consecutively, we wouldn’t be here today. He would be incarcerated for life.'


When it comes to Omni resorts with a knack for delivering the ultimate golf getaways, all eyes have been on Omni PGA Frisco Resort as the sport’s new modern home. But a little further west is a sister property that deserves a spotlight of its own, as Omni Tucson National Resort recently unveiled the results of an incredible multimillion-dollar renovation that will reaffirm its status as one of Arizona’s most incredible vacation settings.
“This long-anticipated renovation marks a whole new era for Omni Tucson National Resort,” general manager Michael Maruca explained. “The entire property has been transformed, inside and out. Guests will be blown away by our Casitas and Hacienda Suites and we cannot wait to welcome visitors and locals alike to experience our new Mokara Spa and differentiated dining outlets.”
He’s not lying. Guests seeking next-tier privacy and comfort are especially going to bookmark the hacienda suites, because they’re more stylish than ever and their golf course adjacency will have everyone waking up ready to tee off. That’s not to say the reimagined casitas and premier and deluxe guest rooms won’t cause a few jaws to drop—there’s simply no wrong choice here. Every accommodation now features an unmistakably Southwestern design that serves to blend the interior with the magnificent natural surroundings.
Also headlining this new era at Omni Tucson is the addition of the 9,000-sq. ft. Mokara Spa, which draws from the regional beauty and immense serenity offered by the desert landscape. A dozen treatment rooms will be used for a variety of therapies and indulgences for all types of guests, but golfers playing a round or two each day will certainly love having such an extensive wellness retreat at their disposal.
Executive Chef Jonathan Stutzman is especially proud of the resort’s new dining concepts, as it was his goal to “put food at the forefront so that more memories around the table will be made.” While the existing options, including local favorite Bob’s Steak and Chop House, have been refreshed and will continue to dish out exceptional, creative meals, they are joined by four more venues that will undoubtedly make this as much a food haven as golf heaven.
Golfers can grab a necessary cup of coffee and snack from Terra Cotta Café on the way to the range or a full morning meal with Southwestern-inspired breakfast choices like the mouth-watering deep-dish quiche with turkey chorizo. After the round, they can head to Legends Bar and Grill for the ideal 19th-hole celebration, and later everyone can toast their games and each other with delicious cocktails at The Peak, which boasts exceptional mountain views.


text:
Good Quality Diner - Toronto
Can anyone recommend a good old-fashioned diner type restuarant for proper home cooked style food - willing to go anywhere in Toronto - have tried a lot of the usual suspects and usually disappointed (frozen fries, canned soup, kraft salad dressing, bad souvlaki, etc.) Does such a thing exist in Toronto??
I like Flo's Diner in Yorkville
I normally go during the week, not as buzy
Friendly service, nice booths and never had a problem with my breaky!
Not sure if it is the down-home cooking natural ingredients however
but I go for the GREASE!
I heard that MIMI'S was good, never been
and there are a few on AVENUE ROAD also

domain: food


FX Wildcat MK2 Laminate PCP Air Rifle. $2,929.00. Compare. FX Wildcat MK2 FX Impact MK2 Black PCP Air Rifle. $3,299.00. Compare. FX Impact MK2 Silver FX. Model. Impact Black MK 2. Origin. Other. Serial. 0098399. Air Rifle Calibre . 177. Air Rifle Mechanism. Pre-charged Pneumatic. Condition. New. Orientation. THE IMPACT MKII - FX Airguns THE IMPACT MKII. Release Date: April 2019. Every so often there are leaps forward in technology that forever change our perception of what is possible. The FX Impact is such a phenomenon and has permanently pushed forward the boundaries of what to expect from an air rifle. FX Impact .30 cal 200 yards - Chicken Sniper - YouTube Nov 05, 2018 · Manufacturer FX Airguns Caliber 0.30 cal Velocity 870 fps Condition New Action Sidelever Barrel Style FX Smooth Twist Fire Mode Repeater Gun Weight 7 lbs Overall Length 34 Barrel Length 24 FX Impact MKII + Power Plenum | Utah Airguns
TopAirGun.com is the number one top-rated air gun store on the internet. Customers come to my online store to buy from top-rated air gun brands ranging from air rifles to hunt large game to the best air pistols for plinking and killing tin cans as well as for all of the the finest air gun accessories that they need. Be sure to test your knowledge and take the fun Air Gun Quiz.
This listing is for a new seal kit for the FX Impact Air Rifle / airgun. Suitable for the Impact MK1. IF YOU HAVE AN IMPACT X or IMPACT MK2 PLEASE CLICK HERE All internal o rings are included in this kit including breech seals and X-rings. Also included are a few of the most … Mark to Market (MTM) Definition - Investopedia Mar 05, 2020 · Mark To Market - MTM: Mark to market (MTM) is a measure of the fair value of accounts that can change over time, such as assets and liabilities. Mark to market aims to provide a realistic FX .22 Wildcat Mark 2 X Twist FAC Sect 1 Pre-charged ... FX .22 Wildcat Mark 2 X Twist FAC Sect 1 Pre-charged Pneumatic Air Rifle (R/H) - New Trade seller - Advertised for 17 days until 9/12/2018 for £1,095 O-Ring Kit For FX Impact - Complete Rebuild Kit 40 Pieces ...
FX Air Gun Accessories for sale | eBay
The FX Impact MKII 700mm has more of a tactical appeal but don’t let that fool you, it has created a huge following as an incredible rifle for hunting while also winning top spots in professional competitions. The FX Impact airgun comes standard with the Smooth Twist X barrel, FX’s latest and greatest innovation. FX Impact X MKII, 700mm | Pre-charged pneumatic Air Rifle ...
FX Hybrid Slugs .22 Cal - 22gr - 100ct. C$21.50. FX Airguns Copy of FX Impact X MKII .25 Cal - 700mm. Achat rapide · Copy of FX Impact X MKII .25 Cal -
FX Airguns - Crown, Streamline, Impact, Wildcat, Bobcat ...
FX IMPACT MK1 .25 CALThe FX Impact is a feature rich air rifle with a tactical design. This all-in-one air rifle has been engineered to satisfy the most demanding airgun shooter with performance features. Equipped with a carbon fibre bottle… £1,699 US$2,104/€1,940. FX .22 Impact MK2 Black Pre-charged Pneumatic Air Rifle (R/H) - New
Добавлено в навигатор Долгожданная новинка от FX попала ко мне в руки не надолго на этой неделе. Главной изюминкой которой 30 Dec 2019 The FX Power Plenum is the newest upgrade to the Impact! Demand for airgun slug shooting has created the need for a larger plenum. MK2. FX mästerverk IMPACT X i Svart edition. Med STX pipan.
Dec 12, 2017 · In this form, the FX Impact costs a cool $1,999.99 for gun alone. Plus about $469.99 for the scope. Plus the rings. So, all-in the FX Impact tested by HAM represents about $2.5K. With additional calibers and a higher-specification scope, it’s easy to see $3,000 as the price for this air rifle. FX Impact Mark 2 Compact - Silver FX Impact Mark 2 Compact - Silver. FX. Description; Specifications; The new, super compact version of the popular FX Impact mark 2 air rifle - Just 25" long! You may order this gun online, however due to the VCR act, we are not permitted to ship directly to you, we can however ship to a registered firearms dealer local to you. Once we receive FX Air Rifle | FX Impact MK2 | Livens Gun Shop


It is undeniable that the machinery industry has been closely related to the national economy, but there are many industries within the machinery industry, with wide product coverage and uneven industrial technology level. Except for a few advanced production and manufacturing technology industries, most industries are not monopolistic. As for China's current machinery industry, some mechanical equipment or manufacturing technology are relatively dependent on imports, and language differences make mechanical translation particularly important, Today, Artlangs Translation Company takes the mechanical document translation as an example to briefly explain what should be paid attention to in mechanical translation.
First of all, Artlangs Translation Company briefly introduces the scope of translation of mechanical documents, which generally includes the translation of mechanical equipment procurement contracts, mechanical drawings, mechanical papers, mechanical equipment specifications, mechanical bidding documents and other materials. They all have one thing in common, that is, they are highly professional. If you want to do a good job in mechanical translation, you must be familiar with the mechanical industry, We must fully understand the relevant background knowledge of the machinery industry and the ever-changing technological updates, otherwise we will not be able to understand the meaning of the original text, and will naturally make some low-level translation errors, which will bring losses to customers.
Secondly, to do a good job of mechanical translation, it is necessary to establish a corpus of various professional standards of mechanical Korean. Take China as an example, the country has comprehensive regulations on professional standards of the machinery industry, such as GB standards, JB standards, JJC standards, HG standards, JG standards and YS standards. In different standards, there are also different regulations on product specifications. Here, Artlangs Translation Company needs to emphasize that it does not require translators to write down so many standards, but requires translators to accumulate and update the professional corpus of machinery industry for a long time based on their ordinary translation experience, which will provide great convenience for future translation work.
Finally, doing mechanical translation well requires continuous learning and accumulation. The machinery industry is different from other industries in that it is not only highly professional, but also rapidly updated. Professional words are often involved in the machinery documents. In order to ensure the consistency of the terminology in the machinery industry, translators need to constantly learn and accumulate. Sometimes, they need to refer to a large number of professional documents. Only by sticking to continuous learning and accumulation, will mechanical translation work bring greater convenience.
The above is the introduction of mechanical translation by Artlangs Translation Company. I hope it can help you. Mechanical translation is highly professional and requires high quality. Therefore, when choosing a translation service provider, we must choose a formal and professional translation company to cooperate.
—— Finish ——


- Engaging in more sustainable solutions is a necessity — not just a corporate responsibility — if businesses want to continue operating in the future, says United Nations Development Program’s administrator Achim Steiner.
- The private sector is a “central player” in paving the way for more sustainable development, Steiner said.
- Corporations need to play a larger role in sustainable development to better adapt to evolving market conditions and to appeal to consumers that are becoming more informed of the social and environmental impacts of certain business practices, he said.
Engaging in more sustainable solutions is a necessity — not just a corporate responsibility — if businesses want to continue operating in the future, says United Nations Development Program’s administrator Achim Steiner.
“Businesses will like the view that ‘once I pay my taxes I’m done with my duty.’ That simply does not work anymore in our age,” United Nations Development Programme’s (UNDP) administrator Achim Steiner told CNBC at the Responsible Business Forum in Singapore Thursday.
Private companies are not just “spectators” but a “central player” for paving the way for more sustainable development — with three quarters of the economy in most countries driven by the private sector, he added.
Companies have “a very clear vested interest” to embrace sustainable development as a functioning economy and stable political system are important for the businesses, Steiner said.
In addition, “inequality as we are observing right now across the world is becoming a major destabilizer,” he added.
Rapid climate changes could also disrupt existing market conditions often taken for granted by corporate leaders, he said.
A recent UN climate change report predicted that world temperatures are on track to rise by around 3 degrees Celsius — a number that is substantially above the target to limit the increase to 1.5 degrees Celsius.
“In the world of business you often have to rely on ‘givens’. You can virtually throw away every scenario about your business and your future markets, your supply chains out of the window. Because by 2050, we will have a world in which many of the fundamental assumptions” may not hold, Steiner warned.
Sustainable Development Goals can provide a framework for businesses to better handle unpredictable market changes in the future, he said. SDGs refer to targets set by the UN to address global challenges such as climate change, poverty and environmental degradation by 2030.
By addressing some of the 17 goals, firms will have a framework to better understand the different business environments and markets they would have to adjust to in the future, Steiner said.
‘Do the right thing’
Companies are pushed toward becoming more conscious of their business practices and social impact as consumers have more access to such information, Steiner said.
“We today live in a market that is rapidly becoming so transparent that virtually every decision in your supply chain, in your production processes and your marketing becomes public knowledge,” he said.
A company’s business decisions would therefore affect the purchasing choices consumers make, he added.
“Companies by conviction or necessity are increasingly looking at their environmental footprint, their social impact and how their product can be an illustration of a social good,” Steiner noted. “Simply put, people want companies to do the right thing.”


text:
This tropical planter loves full sun and is drought tolerant. Pink Rio dipladenias with Bird of Paradise centre and trailing ipomea (sweet potato vine). - Tap the link to see the newly released collections for amazing beach bikinis!
Growing Grapes in Containers . You don't need a big vineyard to grow grapes, you can do this even on your balcony in a pot. Growing grapes in containers is not very complicated though it requires slight care and maintenance. Check out!
Potato Pot: The most environmentally friendly potatoes are grown this way. in Japan ! Make a potato pot by cutting out the sides of a plant pot and putting it inside another one - this makes it easier to lift the plants out for harvesting.

domain: agronomy


text:
Nollywood actress, Princess Chidimma, has used her new post on Instagram to show off her beauty to her fans. She is someone who loves to showcase her beauty in different outfits on social media and she has done it again as she appeared in a lovely outfit. Her followers who came across the post could not help but react as they expressed their opinions in different ways on her page.
In her new post, she showed up with a nice looking hairdo that looks good on her. She applied neatly done make-up that matched her skin color. She appeared in a beautiful outfit that enhanced her beauty.
She put on high heels and a lovely handbag that looked good on her as she took the pictures in a standing position. The actress has been doing well in the movie industry thanks to her talent, which has helped her achieve more fame.
If the comments and reactions on her post are anything to go by, it is safe to say that her followers are impressed with her outfit as they reacted positively to it, while others who admired her hairdo also reacted differently to it.