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This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http://cancer.gov or call 1-800-4-CANCER.
Dramatic improvements in survival have been achieved for children and adolescents with cancer. Between 1975 and 2010, childhood cancer mortality decreased by more than 50%. For acute myeloid leukemia (AML), the 5-year survival rate increased over the same time from less than 20% to 68% for children younger than 15 years and from less than 20% to 57% for adolescents aged 15 to 19 years.
Characteristics of Myeloid Leukemias and Other Myeloid Malignancies in Children
Approximately 20% of childhood leukemias are of myeloid origin and they represent a spectrum of hematopoietic malignancies. The majority of myeloid leukemias are acute, and the remainder include chronic and/or subacute myeloproliferative disorders such as chronic myelogenous leukemia and juvenile myelomonocytic leukemia. Myelodysplastic syndromes occur much less frequently in children than in adults and almost invariably represent clonal, preleukemic conditions that may evolve from congenital marrow failure syndromes such as Fanconi anemia and Shwachman-Diamond syndrome.
The general characteristics of myeloid leukemias and other myeloid malignancies are described below:
TAM blasts most commonly have megakaryoblastic differentiation characteristics and distinctive mutations involving the GATA1 gene.[6,7] TAM may occur in phenotypically normal infants with genetic mosaicism in the bone marrow for trisomy 21. While TAM is generally not characterized by cytogenetic abnormalities other than trisomy 21, the presence of additional cytogenetic findings may predict an increased risk of developing subsequent AML. Approximately 20% of infants with TAM of Down syndrome eventually develop AML, with most cases diagnosed within the first 3 years of life.[7,8]
Early death from TAM-related complications occurs in 10% to 20% of affected infants.[8,9,10] Infants with progressive organomegaly, visceral effusions, high blast count (>100,000 cells/µL) and laboratory evidence of progressive liver dysfunction are at a particularly high risk of early mortality.[8,10] (Refer to the Children With Down Syndrome and AML or Transient Abnormal Myelopoiesis [TAM] section of this summary for more information.)
The presence of a karyotype abnormality in a hypocellular marrow is consistent with MDS and transformation to AML should be expected. Given the high association of MDS evolving into AML, patients with MDS are typically referred for stem cell transplantation before transformation to AML. (Refer to the Myelodysplastic Syndromes [MDS] section of this summary for more information.)
JMML characteristically presents with hepatosplenomegaly, lymphadenopathy, fever, and skin rash along with an elevated white blood cell (WBC) count and increased circulating monocytes. In addition, patients often have an elevated hemoglobin F, hypersensitivity of the leukemic cells to granulocyte-macrophage colony-stimulating factor (GM-CSF), monosomy 7, and leukemia cell mutations in a gene involved in RAS pathway signaling (e.g., NF1, KRAS/NRAS, PTPN11, or CBL).[12,13,14] (Refer to the Juvenile Myelomonocytic Leukemia [JMML] section of this summary for more information.)
CML is a clonal panmyelopathy that involves all hematopoietic cell lineages. While the WBC count can be extremely elevated, the bone marrow does not show increased numbers of leukemic blasts during the chronic phase of this disease. CML is caused by the presence of the Philadelphia chromosome, a translocation between chromosomes 9 and 22 (i.e., t(9;22)) resulting in fusion of the BCR and ABL1 genes. (Refer to the Chronic Myelogenous Leukemia [CML] section of this summary for more information.)
Other chronic myeloproliferative syndromes, such as polycythemia vera and essential thrombocytosis, are extremely rare in children.
Conditions Associated With Myeloid Malignancies
Genetic abnormalities (cancer predisposition syndromes) are associated with the development of AML. There is a high concordance rate of AML in identical twins; however, this is not believed to be related to genetic risk, but rather to shared circulation and the inability of one twin to reject leukemic cells from the other twin during fetal development.[15,16,17] There is an estimated twofold to fourfold increased risk of developing leukemia for the fraternal twin of a pediatric leukemia patient up to about age 6 years, after which the risk is not significantly greater than that of the general population.[18,19]
The development of AML has also been associated with a variety of inherited, acquired, and familial syndromes that result from chromosomal imbalances or instabilities, defects in DNA repair, altered cytokine receptor or signal transduction pathway activation, and altered protein synthesis.[20,21]
Familial MDS and AML syndromes
Nonsyndromic genetic susceptibility to AML is also being studied. For example, homozygosity for a specific IKZF1 polymorphism has been associated with an increased risk of infant AML.
French-American-British (FAB) Classification System for Childhood AML
The first comprehensive morphologic-histochemical classification system for acute myeloid leukemia (AML) was developed by the FAB Cooperative Group.[1,2,3,4,5] This classification system, which has been replaced by the World Health Organization (WHO) system described below, categorized AML into major subtypes primarily on the basis of morphology and immunohistochemical detection of lineage markers.
The major subtypes of AML include the following:
Other extremely rare subtypes of AML include acute eosinophilic leukemia and acute basophilic leukemia.
The FAB classification was superseded by the WHO classification described below but remains relevant as it forms the basis of the WHO's subcategory of AML, not otherwise specified (AML, NOS).
World Health Organization (WHO) Classification System for Childhood AML
In 2001, the WHO proposed a new classification system that incorporated diagnostic cytogenetic information and that more reliably correlated with outcome. In this classification, patients with t(8;21), inv(16), t(15;17), or KMT2A (MLL) translocations, which collectively constituted nearly half of the cases of childhood AML, were classified as AML with recurrent cytogenetic abnormalities. This classification system also decreased the bone marrow percentage of leukemic blast requirement for the diagnosis of AML from 30% to 20%; an additional clarification was made so that patients with recurrent cytogenetic abnormalities did not need to meet the minimum blast requirement to be considered an AML patient.[8,9,10]
In 2008, the WHO expanded the number of cytogenetic abnormalities linked to AML classification and, for the first time, included specific gene mutations (CEBPA and NPM) in its classification system. In 2016, the WHO classification underwent revisions to incorporate the expanding knowledge of leukemia biomarkers that are significantly important to the diagnosis, prognosis, and treatment of leukemia. With emerging technologies aimed at genetic, epigenetic, proteomic, and immunophenotypic classification, AML classification will certainly continue to evolve and provide informative prognostic and biologic guidelines to clinicians and researchers.
2016 WHO classification of AML and related neoplasms
2016 WHO classification of acute leukemias of ambiguous lineage
For the group of acute leukemias that have characteristics of both AML and acute lymphoblastic leukemia (ALL), the acute leukemias of ambiguous lineage, the WHO classification system is summarized in Table 1.[13,14] The criteria for lineage assignment for a diagnosis of mixed phenotype acute leukemia (MPAL) are provided in Table 2.
Leukemias of mixed phenotype may be seen in various presentations, including the following:
Biphenotypic cases represent the majority of mixed phenotype leukemias. B-myeloid biphenotypic leukemias lacking the TEL-AML1 fusion have a lower rate of complete remission (CR) and a significantly worse event-free survival (EFS) compared with patients with precursor B-cell ALL. Some studies suggest that patients with biphenotypic leukemia may fare better with a lymphoid, as opposed to a myeloid, treatment regimen.[16,17,18,19] A large retrospective study from the international Berlin-Frankfurt-Münster (BFM) group demonstrated that initial therapy with an ALL-type regimen was associated with a superior outcome compared with AML-type or combined ALL/AML regimens, particularly in cases with CD19 positivity or other lymphoid antigen expression. In this study, hematopoietic stem cell transplantation (HSCT) in first CR was not beneficial, with the possi


Wimbleon Draw Report:
Venus Eyes Title No. 6
Ashley Marshall | June 30, 2017
Venus Williams' bid for a sixth Wimbledon crown begins Monday against Belgium's Elise Mertens and her road to the final could see her running a gauntlet of the game's elite.
Williams, one of eight American seeds – the most of any nation – in action in London, would play the winner of Qiang Wang or Kai-Chen Chang in Round 2 and could meet world No. 22 Barbora Strycova in Round 3. No. 8 seed Dominika Cibulkova is her possible round-of-16 opponent, while French Open quarterfinalist and No. 4 seed Elina Svitolina could stand in Venus' way in the quarterfinals.
Should Williams reach the final four, she could possibly meet world No. 2 Simona Halep, a runner-up in Paris earlier this month, in the semifinals and world No. 1 Angelique Kerber in the championship match.
Of the other American women's seeds in the English capital, No. ADVERTISEMENT 17 Madison Keys plays Nao Hibino of Japan and No. 25 seed CoCo Vandeweghe plays Mona Barthel of Germany. No. 28 seed Lauren Davis will play fellow American Varvara Lepchenko, one of four all-U.S. matchups in the first round.
Shelby Rogers and Julia Boserup will also square off, with the winner likely to face Lucie Safarova in Round 2, and Alison Riske will play Sloane Stephens.
Among other non-seeded U.S. women in action, CiCi Bellis faces two-time Grand Slam champion Victoria Azarenka, who will be playing her first Grand Slam action in more than a year; Jennifer Brady plays Danka Kovinic; and Madison Brengle plays Richel Hogenkamp. In addition, Bethanie Mattek-Sands plays Magda Linette, while Christina McHale meets hometown favorite Katie Boulter.
Irina Falconi was the lone U.S. woman to advance through the qualifying tournament, beating Mariana Duque-Marino of Colombia, 6-1, 6-4. She will be placed in the draw later on Friday, at the conclusion of the women's qualifying matches.
In the men's draw, top-ranked American Jack Sock starts his campaign against 21-year-old qualifier Christian Garin of Chile, while 23rd-seeded John Isner plays American teen Taylor Fritz, who came through qualifying after skipping the clay-court season to prepare for the summer swing. Fritz, along with Falconi, was one of only two Americans to come through qualifying, with Denis Kudla, Dennis Novikov, Kristie Ahn and Asia Muhammad falling in the final qualifying round.
Among the other men's seeds, No. 24 seed Sam Querrey will play Italy's Thomas Fabbiano and No. 26 seed Steve Johnson faces Nicolas Kicker of Argentina.
Elsewhere on the opening two days of play, Donald Young faces Denis Istomin, rising star Frances Tiafoe plays veteran Robin Haase, Jared Donaldson meets Janko Tipsarevic, Ryan Harrison plays Borna Coric and Ernesto Escobedo plays Adam Pavlasek.
Should the seeds advance through the first two rounds, Sock could potentially meet No. 10 seed Alex Zverev in the round of 32, while Isner would play No. 13 Grigor Dimitrov. Also in that quarter of the draw is seven-time Wimbledon champion Roger Federer and sixth-seeded Milos Raonic. Querrey would be scheduled to meet No. 12 Jo-Wilfried Tsonga in the third round and Johnson could meet former US Open champion and No. 7 seed Marin Cilic.
The top half of the men's draw and the bottom half of the women's draw play on Monday, with the other first-round matches played Tuesday. That means three of 10 American men play on Day 1 along with five of 14 U.S. women.


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For the Indian gems and jewellery industry, now all roads leads from Gujarat to New Delhi. For the first time, the office-bearers of Gems and Jewellery Export Promotion Council (GJEPC) from Mumbai and other leading diamantaires came calling to Gandhinagar to meet and greet State Finance Minister Saurabh Patel with their long pending demands.
Swabhimani Shetkari Sanghatana leader Raju Shetty is confident that Congress too would support its effort to ensure a one-to-one fight against former state finance minister Jayant Patil in Islampur constituency.
Rivals in other constituencies, but bonded in Islampur. Major political parties have united against Nationalist Congress Party leader Jayant Patil in Islampur and plan to support an independent to ensure the former state finance minister’s defeat in the election.
Who will be next CM of Tamil Nadu? While names of many diehard loyalists have been floated, state finance minister O Panneerselvam has emerged the strongest probable.
The outreach of the banking services is still quite poor in Bihar despite the banking channels’ financial inclusion schemes through banking correspondent (BC) model in the state, a fact that has been highlighted in a study report released on Thursday by state finance minister Bijendra Prasad Yadav.
The high commissioner of Malaysia to India, Datuk Naimun Ashakli Bin Mohammad, came down to Nabanna to meet Bengal chief minister Mamata Banerjee on Friday.
State finance minister Amit Mitra concludes the three-day budget debate in state Assembly.
Telangana chief minister K Chandrashekhar Rao's meeting with 14th Finance Commission in Hyderabad commenced.
City BJP MP Anil Shirole has been nominated as member of the finance committee of the central government for the year 2014-15. Your 2 hours a day, thrice a week for 100 days can change many lives. Apply now to volunteer with Teach India at www.teachindia.net for Delhi/NCR & Mumbai region only.
To understand the budget better & create greater awareness amongst all stakeholders, a programme on changes in taxes "Analysis of Finance Bill - 2014" is organized by VIA Tax & Corporate Law forum with galaxy of speakers on Monday between 6 pm and 8 pm. A brief analysis of finance bill 2014 would be done by CA Anil Dani for Income Tax, CA Ashok Chandak for service Tax & Adv GL Deshpande for Excise & custom. The entry is free.
West Bengal Government to set up a separate finance directorate for North Bengal, the government announced on Saturday.
Haryana Finance Department has decided that all bank accounts being operated by the heads of department, in their name or in the name of any other officer, should be closed immediately. Also, the amount lying in such accounts be deposited in the state treasury unless permission for operation has been granted by the department after April 1, 2014.
L&T Finance has informed BSE that the company intends to issue secured, redeemable, non- convertible debentures of Rs 150 crore with an option to retain over-subscription up to Rs 150 crore, an overall amount aggregating to Rs 300 crore on private placement basis.
Harley Davidson India announces enhanced motorcycle finance programmes with HDFC Bank and ICICI Bank.
CPPIB Credit Investments Inc., a wholly-owned subsidiary of Canada Pension Plan Investment Board (CPPIB), and Piramal Enterprises Limited (PEL), announced a strategic alliance for providing rupee debt financing to residential projects across India&rsquos major urban centres. CPPIB and PEL have each initially committed US$250 million for this purpose.
The Uttar Pradesh government today demanded assistance grant and state special grant of Rs 72,526 crore from the fourteenth Finance Commission in addition to devolution from the central fund.
Honda Motorcycle & Scooter India ties up with L&T Finance Holdings for two wheeler loans.
Goan industry on Tuesday demanded a higher share in central taxes in their meeting with the 14 th finance commission that arrived in Goa today and demanded more funds for the creation of infrastructure in the state.
Sundaram Finance's net profit for nine months ending December 2013 increased 7% to Rs 342.27 crore.
Sundaram Finance's deposit base stood at Rs 1,630 crore as on December 2013.
Sundaram BNP Paribas Home Finance's net profit up 15% at Rs 113 crore for the first nine months of FY 14.

domain: news


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This cheesecake makes a large 9" x 13" pan which is perfect for potlucks. My family loves this dessert and it never lasts long!
Ingredients & Directions:
3/4 cup butter or margarine
1 1/2 cups flour
2 tbsp. white sugar
1/3 cup crushed walnuts or pecans
Mix ingredients together and press into a 9" x 13" pan. Bake at 350F for about 8 minutes. Cool.
1 package of cream cheese (250g)
1/2 of a 1L container of whipped topping
1 cup icing sugar
Beat cream cheese and icing sugar. Add whipped topping. Spread on cooled base.
1 package of Lemon Pie filling
Prepare according to package directions. Let cool then spread on top of layer 2.
Spread remaining whipped topping on top of dessert.
Refrigerate until ready to serve.

domain: food


Specialised in the study of public finance, seeing the State as a cooperative and the finances of the State as a co-operative activity on the part of the citizens. This co-operation is to enable citizens to purchase certain services at a lower cost than if they were obtained privately. He saw no clash between public and private needs, both equally needing to be satisfied for the sake of the general welfare.
In his / Dati Scientifici., he described for the first time the characteristics of what is now known as ‘public goods’. Teacher, University Camerino.
Professor Public Finance, Political Economics, University Padua, 1887, 1896.


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Artisan-made Jewelry, Handbags, Home decor and more!
FROM THE COAST
Find that perfect something for that someone special.
New items arriving daily!
Featuring handcrafted jewelry, sculptures, and handbags, as well as distinctive home décor. We make and find beautiful pieces for your personal style and inspiration. These exceptional items are guaranteed to be fun and unique! Shop Florence Oregon, the best gift shop in town, and see them for yourself!
"The ocean stirs the heart, inspires the imagination and brings eternal joy to the soul.”

domain: artistic


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For the 14th year in a row, the road outside the church of ‘Analipseos’ at Neos Kosmos, Athens, was transformed into what looked like a war zone, as locals celebrated the Resurrection of Christ at mass on Saturday with Molotov cocktails, fireworks and fire, filling the streets with flames.
It has become a tradition at Neos Kosmos neighbourhood for the streets to appear as though a war has started as soon as the priest says “Xristos Anesti.”
This year because of the country's existing curfew due to the pandemic, the tradition had to be brought forward.
According to the decision made by The Holy Synod, the governing body of the Church of Greece, the mass took place at 9pm instead of at midnight as it is traditionally held.
Local residents and people from many regions across Greece arrive at Neos Kosmos during the Easter period to witness this unique custom, as crowds gather at spots that are considered safe and distant enough to enjoy the spectacle.
Watch the video here:
Image by Eurokinissi

domain: sociology


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Imperfect - Waldorf Education: An Introduction for Parents
Damaged/Imperfect - mildly out of kilter: a bent corner, a ruffled page or three, a spine with a dent, or a mark that ought not to be there. Final sale, no returns or exchanges. Quantities are limited.
Looking for a comprehensive overview of Waldorf Education from kindergarten to twelfth grade? This book is the very thing! Essays by experienced Waldorf educators at every level address the genius in the Waldorf school approach and describe the curriculum and how it meets the development of the young. Research on the results of Waldorf education, offering a profile of the Waldorf school graduate derived from research on Waldorf graduates gives prospective parents and educators everywhere a picture of where Waldorf high school graduates go and what they do once launched into adulthood. This short book is a succinct and thorough overview of all things "Waldorf."
6 x 9 inches

domain: literature


Invitation to the Advanced School on Impedance Spectroscopy (ASIS) in Chemnitz, Germany
We are pleased to invite you to the Advanced School on Impedance Spectroscopy (ASIS), which is going to take place at the Technische Universität Chemnitz, Chemnitz, Germany on September 26th and 27th 2017. The aim of ASIS is to give scientists a better and wider understanding of the method of Impedance Spectroscopy. We offer a range of tutorials, held by selected international experts, which will explain the method from different angles, such as impedance modeling, consistency check, electronic circuits design, embedded system design and instrumentation. Beside the fundamentals of impedance spectroscopy, advanced topics on the application of impedance spectroscopy in material characterization, electrochemistry, biology and microscale impedance sensors will be covered as well.
It is open for all:
- Undergraduate students
- Graduate student
- PhD students and post-doctoral fellows as well as
- Engineers and scientists at both industry and universities
The language of tutorial will be English. For further information about the advanced school lectures and tutors please visit ASIS webpage (https://www.tu-chemnitz.de/iwis/advanced_school.php).
With the registration you will receive tutorial materials, abstract book, lunch, ASIS Get Together dinner and the option to attend the International Workshop on Impedance Spectroscopy 10-year-anniversary ceremony.
Please find highlights and more information here:
- Registration deadline: Sep 10, 2017
- ASIS Get-together: Sep 25, 2017 at 19:00 in Miramar Chemnitz
- Starting: Sep 26, 2017
- Finishing: Sep 27, 2017


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Thermal Anisotropy in Nano-Crystalline MoS2 Thin FilmsPhysical Chemistry Chemical Physics
AbstractIn this work, we grow thin MoS2 films (50–150 nm) uniformly over large areas (>1 cm2) with strong basal plane (002) or edge plane (100) orientations to characterize thermal anisotropy. Measurement results are correlated with molecular dynamics simulations of thermal transport for perfect and defective MoS2 crystals. The correlation between predicted (simulations) and measured (experimental) thermal conductivity are attributed to factors such as crystalline domain orientation and size, thereby demonstrating the importance of thermal boundary scattering in limiting thermal conductivity in nano-crystalline MoS2 thin films. Furthermore, we demonstrate that the cross-plane thermal conductivity of the films is strongly impacted by exposure to ambient humidity.
PublisherRoyal Society of Chemistry
Citation InformationChristopher Muratore, Vikas Varshney, Jaime J. Gengler, Jianjun Hu, et al.. "Thermal Anisotropy in Nano-Crystalline MoS2 Thin Films" Physical Chemistry Chemical Physics Vol. 16 (2014)
Available at: http://works.bepress.com/christopher-muratore/7/

domain: chemistry


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New (never used)These gorgeous brand new cufflinks come from The Metropolitan Museum of Art’s Robert Lee Morris collection. They feature 24k gold overlay and were produced for The Met by Mr. Morris, based on his original designs, ca. 1981-87, currently in the collection of The Costume Institute. They’re brand new, with tags and original documentation, as well as a cute gift box. You’d be all done with Father’s Day in one fell swoop! Robert Lee Morris is one of America’s most celebrated contemporary jewelry designers. He has won the prestigious Coty Award, and two Council of Fashion Designers pf America Awards. He’s also received the Geoffrey Beene Lifetime Achievement Award from CFDA. Original retail was $175. I’m asking only $50! Thanks so much for looking & Happy Father’s Day!
Sterling, VAMap is approximate to keep the seller's location private


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As of September 10th, 2013 the American Academy of Dermatology in Schaumburg, Illlinois has demonstrated "Tips for Healthy Nails", a video posted to the Academy website as part of the Dermatology A to Z: Video Series. This series offers videos that demonstrate tips to properly care for the skin, nails, and hair. A new video is posted monthly to show that healthy skin and nails lead to less sickness and infection.
Dermatologist Pheobe Rich, MD, FAAD, clinical adjunct professor of dermatology at Oregon Health Science University, Portland, gives many tips to having healthy natural nails. "Never bite your nails or remove cuticle. Not only do these actions DAMAGE the nail, they also increase the risk of infection." Nails are more then just for beauty, they effect your over all health too.
Celebrating over 75 years of promoting healthy skin, hair, and nails, the American Academy of Dermatology is the largest, most influential of all dermatologic associations. They currently hold more then 17,000 physicians worldwide, and are committed to advancing the diagnosis and medical, surgical and cosmetic treatment of the skin, hair, and nails.
You can find these dermatologists suggested by the American Academy of Dermatology locally in Fort Myers.
- Anais Aurora Badia DO 1-239-561-3376
- Debra D. Fett Desmond MD, FAAD 1-239-694-7546
- Sandy Martin MD, FAAD 1-239-694-7546
- Nancy Schleider-Kushner MD, FAAD 1-239-768-2057
- John L. Snow MD, FAAD 1-239-274-0005

domain: medical


Existing levee patrol roads located adjacent to the Yolo Bypass and Willow Slough Bypass within the boundaries of Reclamation District 2035.
Notice of Exemption
Type, Section or Code
S: 15301,(c),(d), 15302
Reasons for Exemption
The Project involves the operation, repair, maintenance or minor alteration of existing public structures, facilities or topographical features involving negligible or no expansion of sue beyond the existing use, & to the extent any existing structure/facility is replaced or reconstructed, the new structure will be located on the same site as the structure replaced & will have substantially the same purpose and capacity as the old structure.
The document was originally posted before CEQAnet had the capability to host attachments for the public.
To obtain the original attachments for this document, please contact the lead agency at the contact information listed above.
You may also contact the OPR via email at firstname.lastname@example.org or via phone at (916) 445-0613.


By Eddie G. Alinea
MANILA, Philippines (3 Jan 2012) – Two days from today on Friday (Saturday in Manila), undefeated American World Boxing Council welterweight champion Floyd Mayweather Jr. starts his 90-day jail term handed down by a Las Vegas Justice of the Peac Judge Melissa Saragosa following his plea of guilt on a lesser domestic violence charge filed by his ex-wife in 2010.
Meaning, he will be living behind bars until no earlier than March in the process killing all the hopes of seeing him face Filipino belt holder of the World Boxing Organization’s (WBO) 147-pound division planned to be staged May 5 in Las Vegas.
But while the 42-0 win-loss record owner would be in complete hiatus in that stretch of time, and perhaps the whole of 2012 should decisions on his other cases are promulgated, Pacquiao, the eight-division belt owner would be as busy as in the past decade vowing to continue his campaign both atop the ring besides performing his responsibilities as a lawmaker representing the Province of Sarangani in the Halls of Congress.
“Yes, Manny will be as busy fighting even without Mayweather,” this, Pacquiao’s American trainer Freddie Roach declared. “The Mayweather fight can wait, but we can’t wait for him.”
“We’re going to fight in May or in June,” Roach vowed in a telephone interview with this writer. “We don’t know yet the exact date, but for sure, our first fight in 2012 will in the spring as a tradition the past several years. The regular scheduled second bout could be held as usual in November.”
“If Floyd is available and is willing to accept the challenge, then we’ll go for him because not only has Manny already reiterated his willingness to face him but, as we already know, that’s the fight the entire boxing world has been craving for for many years now,” the Boston-born five-time ‘trainer of the year’ awardee said.
Roach would not name though who he wants his ward fight next, except to say that at least four name are being mentioned -– world lightweight champion Juan Manuel Marquez, whom the RING MAGAZINE pound-for-pound best had disposed off via a majority decision last November 12, another former victim Miguel Cotto, world junior welterweight titleholder Tim Bradley and Lamont Peterson.
Roach denied earlier reports that he prefers Peterson to be the Pacman’s initial opponent for the year than the other three simply saying that anyone could prove a good tuneup just in case the much-awaited mega Pacquiao-Mayweather confrontation turns a reality.
In terms of public interst and financial benefits, Marquez, as Top Rank’s Bob Arum personal choice, could be it. The Filipino and the Mexican “Dinamita” have fought in trilogy but the outcome, although in favor of Pacquiao, 2-0-1, win-loss-draw, have not been decisive as to who between them is the better boxer.
Roach agreed that Cotto, whom the Filipino ring hero, who turned 33 last December 17, knocked out in the 12th round to wrest the WBO 147-pound crown in 2009, would be another good choice.
The Briton is coming from an impressive victory over Antonio Margarito to bounce back from that annihilation and getting revenge for the first loss of his career back in 2008.
Bradley came into the equation as a likely candidate when he was signed by Top Rank last year after emerging triumphant over Jose Casamayor in the undercard of the Pacquiao-Marquez III.
Like Peterson, who surprisingly beat another Rolach protégé Amir Khan to make it in the list, Bradley is not yet a big pay-per-view draw and, therefore, cannot be considered as a possible a bankable opponent.
Pacquiao was also vocal in having interest to fight Marquez for the fourth time, but, the Mexican’s numerous demands can prove the hindrance to make this possible.
Besides asking for a bigger share of the purse than their third meeting, he, likewise, demands that the bout be held elsewhere than Las Vegas.
Believing, again, that he won the third confrontation, Marquez wants Chapter IV of protracted confrontation staged in Mexico, his hometown, or Texas.
Roach, of course, would not want that to happen saying, in an earlier interview that Marquez has no right to demand as he is not yet the champion. Or something to that effect. (PNA)


Glossier Introduces Their Latest Product "Boy Brow"
Glossier is back with a new product. Boy Brow is the latest innovation to come out of the Glossier lab and the timing couldn’t have been better. Cara Delavigne has made thick brows a style staple for the past year, and we don’t see this trend fading anytime soon. Glossier has long since felt that …
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Hand-poured Bee Pure Candles are uniquely better in these ways.
* Wax comes from Oregon-based bees that are given no harsh mite pesticides typically applied in commercial-model beekeeping.
1. Use of nerve-damaging chemicals are toxic to bees, other living creatures, and they readily pass through bees to your candle wax. Toxins concentrate in wax just as they do in fatty animal tissue.
2. Wax is raw, not processed. Color variations come from traces of bee pollen, honey and propolis (natural bee weatherization glue). All healthy.
3. Original, beautiful shapes and burning qualities. Tapers reveal castle spire points, egg, globe, hive and cone reveal their patterns in relief as wick flame shines from within the candle.
4. Bee Pure Candles are also unique in that no two look exactly alike. Poured in small batches in my Portland, Oregon basement - there is handcrafted candle individuality in each one.
5. 5% of profits go to support LiveHoneybees, which teaches about the connection between bees and people.
1. Extremely clean 100% beeswax 2. Unique shapes 3. Percentage of sales supports honeybee education/restoration programs
No reviews available. Be the first!


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Kurumba Maldives has been nominated for five categories at the prestigious World Travel Awards 2020.
The award, established in 1993 acknowledges, rewards, and celebrates excellence across all key sectors of the travel, tourism, and hospitality industries and is recognized globally as the ultimate hallmark of industry excellence. The red-carpet event will take place at Kenyatta International Convention Center (KICC), Nairobi, Kenya on 3rd October this year.
Kurumba Maldives has been nominated for the following categories this year:
– Maldives’ Leading Beach Resort
– Maldives’ Leading All-Inclusive Resort
– Indian Ocean’s Leading Beach Resort 2020
– Indian Ocean’s Leading Family Resort 2020
– Maldives’ Leading Family Resort 2020
To cast your vote for Kurumba Maldives at this year’s 27th Annual World Travel Awards™ 2020 https://www.worldtravelawards.com/vote
Kurumba Maldives is set on a tropical island in the North Male Atoll, conveniently located a brief 10-minute speedboat ride away from the airport and Male, the Maldivian Capital. Dotted with coconut trees that are the island’s namesake, Kurumba was the first private island resort in The Maldives. Lush tropical gardens, white sandy beaches, and a vibrant house reef are the hallmarks of this classic Maldivian resort.

domain: geography


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13-Year-Old Girl Crushes Meshuggah’s ‘Clockworks’ on Drums
Wow! 13-year-old Alexey Poblete just covered Meshuggah’s “Clockworks” on drums and made it look damn easy.
Meshuggah had an incredible 2016 with The Violent Sleep of Reason, which was widely acclaimed by fans and critics alike. “Clockworks” is the album’s opening cut, kicking the record off with polyrhythmic brutality. Tomas Haake just keeps proving why he’s one of metal’s all-time great drummers, crafting a style completely unmatched by his peers. Playing along with Haake’s parts is a nightmare for most drummers due to his unconventional rhythms and rapid-fire time signature changes, which is why Alexey’s video is so impressive.
The 13-year-old rocker has posted plenty of covers on YouTube, including a play-through of Rush’s “YYZ” and Slayer’s “Raining Blood.” She’s also done Animals as Leaders, which may have gotten the attention of guitarist Tosin Abasi. The guitar phenom shared Poblete’s “Clockworks” cover on Facebook, bringing tons of attention to the young drummer. Alexey graciously thanked Tosin and has been getting tons of positive reactions.
Watch Alexey Poblete crush Meshuggah’s “Clockworks” in the clip above! And no, everyone, the tattoos aren’t real.
See Meshuggah in the 20 Best Metal Albums of 2016
Meshuggah - Wikipedia: Fact or Fiction?


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“Treat the patient in a timely and cost-efficient manner with an emphasis on proactive healthcare.”
Dr. Sally Sartor joined the Green Clinic Ear, Nose, and Throat department in 1990. The varied disease processes encountered in otolaryngology interested Dr. Sartor, as well as the opportunity to help patients in all age groups. Dr. Sartor performs pressure equalization tube placement, tonsillectomy and adenoidectomy, balloon sinuplasty, plastic reconstruction, medically necessitated blepharoplasty, head and neck skin cancer removal, and allergy testing. New patients can expect to be listened to and cared for in a friendly atmosphere. She is currently accepting new patients at both the main Green Clinic location in Ruston and her satellite office in Winnsboro.
1200 South Farmerville Street
502 Prairie Street

domain: health


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The collective bargaining for the approximately 2.5 million employees in the federal government and in the municipalities go into the second round on Wednesday. It's about fair pay, competitive working conditions and motivated employees, said the head of the civil servants' association dbb, Ulrich Silberbach. "We finally want to hear constructive ideas and offers. Otherwise, the conflict and the strikes will intensify."
Verdi boss Frank Werneke told the newspapers of the Funke media group that the willingness to take part in campaigns was more pronounced among the employees than it had been for a long time. "There's real pressure on the boiler now." Some of the warning strikes that have been going on for days are to be continued on Wednesday.
That's what the demands are
The dbb called on the municipalities to support their employees in the fight. "Instead of against their own employees, the municipalities should rather fight with them for better financial resources," said Silberbach. We are aware of the corresponding concerns of the city treasurers, but "the situation is not the fault of the colleagues or an income development that is getting out of hand. The responsibility for this lies with the federal government and above all with the federal states, which support the cities and municipalities financially bleed out."
So far, there has been no significant rapprochement in the collective bargaining dispute. Verdi and dbb are calling for an increase in income of 10.5 percent for federal and municipal employees, but at least 500 euros per month for a period of twelve months. According to the Federal Ministry of the Interior, the minimum amount in the lower pay groups would result in increases of over 20 percent in some cases. Apprentices, students and interns should receive 200 euros more per month.
Employers reject this as economically unacceptable. Negotiations continue on Wednesday and Thursday in Potsdam.
High additional costs as a result
The negotiations concern, among other things, educators, nurses, bus drivers, geriatric nurses, firefighters, garbage workers and a number of other professions that are employed by the federal government or the municipality. A separate collective agreement applies to the employees of the federal states.
According to the Association of Municipal Employers' Associations (VKA), the cost of the required wage increase for municipal employers would amount to around 15.4 billion euros. According to the Ministry of the Interior, this would result in additional costs of around 1.4 billion euros per year for the federal government.

domain: finance


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As this year comes to an end, some of us will reflect upon the past while some of us will start to plan for the future. What can you do to make this New Year better than the past ones? If you continue to do the same things, you will continue to get the same results. A change is needed if you wish to have a better sense of awareness, belonging and happiness. Let this New Year be a year of a new you. Do things that you have always felt like doing but felt restricted for some reason. Follow the path that seems a little scary but yet feels so right in your heart. Of course, when you take risks there is always a chance that you may not find success and get hurt. But no one has discovered the truth of life by following the safe, easy route. Mistakes and experiments are part of our journey. Don’t be afraid to venture into uncharted territory!
Here are some suggestions to create a new you in the New Year:
1) No resolution is the new resolution
Ask yourself what happens to your resolutions a month after you create them? They disappear for most of us. Most people even casually joke about it. Your soul has a tendency to evolve all the time but if you restrict yourself for a future promise, the soul wouldn’t want to restrict itself. It will continue to move toward your deep conditioned conscious choice. Hence, setting your resolution, in my opinion, is blocking yourself from any new experience. I am not saying that you shouldn’t set any dreams or visions for yourself. Planning is good, but keep some space for new opportunities to open up. Replace your resolutions with ILU in New Year. ILU stands for intention, love, and unity in your vision for the New Year.
Intention – Your intention is more important than your action. The right intention will generate the right circumstances to happen. When you visualize what you would like to see in your life, ask yourself what you intend to achieve out of it? Make sure your intention contributes to your wellness and to those around you.
Love – Any resolution or goal is irrelevant if there’s no love in it. Do you feel loved while working for your goal? Will you be able to give love to others when you will be pursuing your dream? The vibrations of love will help you to set an uplifting mood for the upcoming year.
Unity – Unity refers to the unified consciousness residing in you. Unified consciousness refers to a state where you experience yourself as more than your physical body, social status, and financial signature. You experience highest state of awareness in this sacred stage. Your vision must be set keeping in mind that it will help you reach the higher states of your soul.
2) Trinity of being whole
Acceptance – Accept yourself as a whole, otherwise your personality will always reflect a hole in it. It’s quite obvious that in this age of the never-ending rat race, you will be told to become something and to achieve a certain target in life. But in this conquest of becoming something, you may end up losing your original self.
Forgiveness – We all make mistakes. It is human to err every now and again. But fear not, because your human wrongdoings will eventually lead you to a divine doing. Just allow yourself to move without the fear of making a mistake. Forgive yourself often. This is an important part in accepting yourself as a seeker.
Togetherness – The concept of being together is so hyped and yet so underutilized. We need to revisit the whole art of togetherness. Start being together with your inner self to begin with and then work on being together with the people around you. For example, the word “soulmate” is so unfairly restricted to just romantic couples. Rather, this word should apply to the entire globe. Soulmate literally means friend or mate of the soul. Imagine a world where we treat everyone as a friend of the soul! Wouldn’t that be wonderful?
The best example to learn from is the mother-child relationship. A child becomes a child because of the mother. A mother gets the title of mother only because of the child. No matter how many arguments or hardships happen, a mother and child will never stop loving each other. The bond between them is so strong that nothing can shake the relationship. This is exactly how we need to build the togetherness in our souls. Let this New Year be a year of togetherness!
Meditation for a new you in the New Year
Take a deep breath and sit with your spine straight.
Watch your breath silently for the next few moments.
Bring your awareness to your heart and create your intention. Your intention could be stated as, “My intention is to experience my highest potential in the New Year. I intend to be at my very best every day in every way.”
Release the intention with faith that it will be manifested in its own time.
Take your awareness to your third eye and keep watching your third eye for the next few moments.
Very gently, start your mantra* or affirmation. Continue to repeat it for a few minutes.
Conclude your meditation by expressing your sincere gratitude to the Universe.
*Do the mantra that you have already been doing. If you don’t have a mantra, you may do Lord Shiva’s mantra: Om Namaha Shivaya, which means: I am pure consciousness. I am pure awareness.
Keep a clean space for meditation.
Light a candle or burn some incense if they help you to create a better environment.
Wear relaxed and clean clothes.
Repeat the meditation every day for good results.
Chandresh Bhardwaj is the founder of the self-realization center – Break The Norms Movement, and has launched Uncensored Spirituality Foundation. Bhardwaj is one of the youngest inspirational new age teachers and the seventh generation spiritual guide pursuing initiatives in the eastern science of healing and transformation. He conducts public talks and workshops.He is a published writer and promotes spiritual dialogue in meditation, repressed emotions, and Tantra. www.cbmeditates.com

domain: psychology


Left to right are: Dr Declan Teare, Yeovil Ales; Guy Sheppard, SIBA competitions chair; and Darren Batten, Palmers Brewery
The awards took place prior to the famous Tuckers Maltings Beer Festival in Newton Abbot.
Tally Ho was named overall champion cask beer and is described as strong, complex, and full of deep distinctive notes, with a rich fruit cake flavour. First brewed in the 1940s, the dark, strong old ale has a loyal following.
YPA took overall gold in the bottleand can competition and is a a smooth, fruity beer. Notes of citrus fruit and sweeter peaches and apricots are provided by a well-crafted blend of pale malts and aromatic hops.
SIBA competition chair, Guy Sheppard, said: “The new outdoor venue has proved a great success, and the quality of the beers this year has been as high as ever, with some amazing cask, bottle and canned beers on show in the competition.
“I would like to congratulate all of the winners and, in particular, the overall golds, which really are the best of the best craft beer from the South West.”
Darren Batten, from Palmers Brewery, said: “On our 225th birthday, it’s thrilling to win the top gold for Tally Ho at the SIBA South West beer competition. It’s a treat, I’m lost for words!”
Dr Declan Teare, head brewer at Yeovil Ales, said: “Given the amazing quality of beers in the South West, it’s incredible to be judged by our peers with YPA as the best bottled beer in the region. Yeovil Pale Ale is our double IPA style, easy-drinking beer, and it’s one of our favourites!”


Swinney Named ACC Coach of the Year
Will be presented with the award Thursday.
The Home Depot Coach of the Year Award will be presented to Clemson’s Dabo Swinney as a part of The Home Depot 25th Anniversary College Football Awards on Thursday, Dec. 10, at 7 p.m. ET, on ESPN. Swinney led the Tigers (13-0, 8-0 ACC) to an undefeated regular season, the Atlantic Coast Conference title and the No. 1 seed in the College Football Playoff. In addition, The John Mackey Award will also recognize Hunter Henry of Arkansas as outstanding tight end during The Red Carpet Special at The Home Depot College Football Awards.
With Swinney at the helm, the Tigers defeated three top-25 teams in the Associated Press poll (No. 6 Notre Dame, No. 17 Florida State and No. 8 North Carolina) and earned six straight No. 1 rankings by the College Football Playoff. Under Swinney, Clemson posted nine straight games with at least 500 yards of total offense. He has led the Tigers to the longest active winning streak in the nation (16 games), dating back to last season. The No. 1 Clemson Tigers will face No. 4 Oklahoma in a College Football Playoff Semifinal at the Capital One Orange Bowl on Dec. 31, 2015 at 4 p.m. on ESPN.
Henry, a junior from the University of Arkansas, has been named the country’s outstanding tight end by the Friends of John Mackey, becoming the second winner from Arkansas. Arkansas now becomes the only school in the 16 year history of the John Mackey Award to have multiple award winners, as D.J. Williams won in 2010. Henry will be presented with The John Mackey Award during The Red Carpet Special at The Home Depot College Football Awardson Thursday, Dec. 10 at 6 p.m. on ESPNU.
This season, Henry recorded 46 receptions for 647 yards and three touchdowns and led all SEC Tight Ends in receptions, receiving yards and first downs. He has not dropped a pass through 13 games, dating back to last year’s bowl win over Texas. His outstanding blocking has been on display all season as Henry hasn’t allowed a sack or even a quarterback hurry this year. Hunter and the Razorbacks will face Kansas State in the AutoZone Liberty Bowl on Jan. 2, 2016 on ESPN.
The John Mackey Award is given to the collegiate tight end who best exemplifies the play, sportsmanship, academics, and community values of NFL Hall of Fame Tight End John Mackey.
The Rimington Trophy (outstanding center) and the Wuerffel Trophy (community service) will also be presented during The Red Carpet Special at The Home Depot College Football Awards. Jack Allen (Michigan St., Sr.), Austin Blythe (Iowa, Sr.) and Ryan Kelly (Alabama, Sr.) are finalists for the Rimington Trophy; and Ty Darlington (Oklahoma, Sr.), Landon Foster (Kentucky, Sr.) and Nate Sudfeld (Indiana, Sr.) are finalists for the Wuerffel Trophy.
The 25th annual awards show will feature with the live presentation of:
§ Nine National College Football Awards Association (NCFAA) player awards
§ The NCFAA Contributions to College Football Award to Barry Switzer
§ The Home Depot Coach of the Year Award to Dabo Swinney
§ The Disney Spirit Award to Hank Goff
§ The National Football Foundation’s William V. Campbell Trophy
§ Student-athletes selected to the Walter Camp All-America Team and The Allstate AFCA Good Works Team®
A live Twitter vote will allow fans to determine the college football Play of the Year. The four top plays to pick from at ESPN.com include Miami’s unbelievable finish vs. Duke, Stanford wide receiver Francis Owuwu’s jaw-dropping catch, Georgia Tech’s wild finish vs. Florida State and Michigan State’s miracle in the Big House. Viewers can vote during the show by tweeting using #PlayOfTheYear and the school name.
Full details on this year’s presenters, finalists and the entire day of college football awards programming.
National College Football Awards Association (NCFAA)
The NCFAA encompasses the most prestigious awards in college football. The 21 awards boast 678 years of tradition-selection excellence. Visit www.NCFAA.orgto learn more about our story.