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FDA grants accelerated approval to sacituzumab govitecan for advanced urothelial cancer
- S&P 500, Dow end at record highs as weak jobs data eases rate worries
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On April 13, 2021, the Food and Drug Administration granted accelerated approval to sacituzumab govitecan (Trodelvy, Immunomedics) for patients with locally advanced or metastatic urothelial cancer (mUC) who previously received a platinum-containing chemotherapy and either a programmed death receptor-1 (PD-1) or a programmed death-ligand 1 (PD-L1) inhibitor.
Efficacy and safety were evaluated in TROPHY (IMMU-132-06; NCT03547973), a single-arm, multicenter trial that enrolled 112 patients with locally advanced or mUC who received prior treatment with a platinum-containing chemotherapy and either a PD-1 or PD-L1 inhibitor. Patients received sacituzumab govitecan, 10 mg/kg intravenously, on days 1 and 8 of a 21-day treatment cycle.
The main efficacy endpoints were objective response rate (ORR) and duration of response (DOR), evaluated by independent review using RECIST 1.1 criteria. The confirmed ORR was 27.7% (95% CI:19.6, 36.9) with 5.4% complete responses and 22.3% partial responses. The median DOR was 7.2 months (n=31; 95% CI: 4.7, 8.6; range 1.4+, 13.7).
Most common adverse reactions (incidence >25%) in patients receiving sacituzumab govitecan are neutropenia, nausea, diarrhea, fatigue, alopecia, anemia, vomiting, constipation, decreased appetite, rash, and abdominal pain.
The recommended sacituzumab govitecan dose is 10 mg/kg once weekly on days 1 and 8 of 21-day treatment cycles until disease progression or unacceptable toxicity.
View full prescribing information for Trodelvy.
This indication is approved under accelerated approval based on tumor response rate and duration of response. Continued approval for this indication may be contingent upon verification and description of clinical benefit in a confirmatory trial.
This review used the Real-Time Oncology Review (RTOR) pilot program, which streamlined data submission prior to the filing of the entire clinical application, and the Assessment Aid, a voluntary submission from the applicant to facilitate the FDA’s assessment. The FDA approved this application 6 weeks ahead of the FDA goal date.
This application was granted priority review and fast track designation. A description of FDA expedited programs is in the Guidance for Industry: Expedited Programs for Serious Conditions-Drugs and Biologics.
Healthcare professionals should report all serious adverse events suspected to be associated with the use of any medicine and device to FDA’s MedWatch Reporting System or by calling 1-800-FDA-1088.
For assistance with single-patient INDs for investigational oncology products, healthcare professionals may contact OCE’s Project Facilitate at 240-402-0004 or email OncProjectFacilitate@fda.hhs.gov.
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DO I KNOW ME?
I am nice… I am good… I am a happy person… Oh really?
There are things we thought we know of ourselves but sometimes we really don’t know them yet. Thus the question, “Do I know me?”. We sometimes mistake ourselves from choosing between who we truly are and who we want be. Most often we set our minds that we are these because we don’t want people to look at us differently. We are afraid of being judged and scrutinized. But does that really matter? What’s wrong with being who you really are?
We are all created as unique individuals – different traits, diverse personalities and varying preferences. What we need is to trust in what we really are. Once we have that trust, it will rub to the people around us. If we know that we are living in this world without doing any harm to others, then we should not fret. Being who you are is something that really takes out all barriers. It is freedom and it is a happy feeling.
So go on and release your true being so that when the time comes that you ask if you really know yourself, your answer is gonna be a definite YES.

domain: sociology


text:
Transitional Care Clinic
The Transitional Care Clinic is committed to helping heart failure patients improve their quality of life through education and encouragement.
A skilled team of professionals works closely with patients to develop an individualized treatment plan based on medication compliance, diet, exercise, and lifestyle changes.
Transitional Care Clinic
Melissa Rehkemper, NP-C, explains that Memorial’s Transitional Care Clinic sees patients with chronic disorders like heart failure and lung disorders such as COPD. The clinic is in between both the provider and patient going home. The team at the Clinic makes sure that the patient is doing well and that they have all the resources that they need to have a high quality of life. They work closely with the patient’s healthcare provider—whether it be pulmonologist, cardiologist, or primary care provider—and collaborate with them to make sure they have all those resources.
When do patients first come in contact with the Transitional Care Clinic?
Shannon Abram, RN, discharge transition coach describes the process, “When they come into the hospital with the diagnosis of heart failure, we see them on the floor; we do intensive education to try to make sure they know what to do when they go home to take care of themselves. That may involve things like getting them outside services too like home care, palliative care, help with medications, help with insurance.”
The Clinic even has a pharmacist on staff to assist with patients.
“I see the patients usually shortly after they’re discharged from the hospital and then every couple weeks thereafter,” says Lauren Eversgerd, pharmacist. “When they’re discharged from the hospital, we like to go over their medicines, make sure nothing got missed on the discharge process. These patients are seeing multiple providers to where we making sure they’re on all appropriate medicines that aren’t going to interact with each other you have any problems. I also like to sit down with the patients and explain to them why they’re taking all of these medicines because some of them are like, ‘Well, can I just take one blood pressure pill? Why do I need five?’ and so it’s really about how we can empower the patients to help teach them to take care of themselves and make sure they know the why of why we’re doing everything that we’re doing for them.”
Because diet is such an important part of a heart-healthy lifestyle, the team also includes a dietitian.
Registered Dietitian Pam Nicholson explains, “The first thing we do is visit the patient and do what we call a nutrition history so we can assess what habits are, what they usually eat at home, what’s available to them at home, and what their living conditions are…like is somebody there to cook for them, do they do their own shopping, just where do they get their foods. And then from there, we just intervene to help teach them what heart healthy eating is. You know if this is a normal food that you’re used to having do we need to make some changes, make alternate suggestions of things to focus in on for their food choices. It is a very big change because the main focus for a heart failure diet is sodium and that changes the taste of the food dramatically is a good word. A lot of people are resistant to that, but hopefully we can explain to them the whys and wherefores of why they’re being tortured into a special diet. Yes, I think it does take time for their taste buds to readjust, and we always try to encourage that they just give the whole idea time try, to give them lots of seasoning ideas beyond using a sodium based product. There’s lots of herbs and lots of spices and things that we could do an alternative way and try to encourage them to have an open mind about it.”
What do you enjoy most about working in the Transitional Care Clinic?
“Being able to build a relationship with my patients,” says Melissa. “Getting to know them on a one-on-one basis, and that’s just really what attracted me to this position. And providing patient education has always been my love and passion, so I love educating patients and just getting to know them and sitting down and talking.”

domain: medical


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WASHINGTON—President Barack Obama has decided to cut the size of the American force in Afghanistan by half over the next year, in an acceleration of the U.S. departure.
State of the Union
Mr. Obama, who announced the plan in his State of the Union address Tuesday, will order a reduction in the troop levels by 34,000, from the total of 66,000 American troops now, by this time next year.
The plan represents the first time the administration has spelled out the rate of troop reductions under a new strategy, and signals a speedier withdrawal than military commanders initially recommended. But defense officials said commanders have signed off on the plans, satisfied that a planned shift to a strategy focused on training Afghan forces would allow for an accelerated drawdown.
The move will reduce troop numbers to about the same level as when Mr. Obama took office in 2009. He ordered a buildup that increased U.S. forces to more than 100,000, many sent as part of a surge that ended last year.
A final decision has yet to be made on the size of a post-2014 U.S. troop presence, officials said, with the level likely to range up to 9,000.
Mr. Obama, in his address, did not spell out post-2014 troop levels, but said the U.S. commitment to Afghanistan would continue, though changed. The administration is seeking an agreement with the Afghan government, he said, that allows the U.S. to pursue extremists and train the country's military to ensure that Afghanistan "does not again slip into chaos."
Gen. John Allen, the former top commander in Afghanistan, originally hoped to keep the current troop levels through the end of the fighting season in the fall. Mr. Obama's decision last month to shift more quickly to an emphasis on training Afghan security forces—and conducting fewer joint military operations—has eased the need for high levels of troops, officials said.
"Afghan forces are leading nearly 90% of operations across the country, and by this spring, they'll be assuming the lead across the entire country," said a senior administration official, with the U.S. in a training and assisting role.
Some Afghan officials and analysts, who favor a larger U.S. presence, saw the drawdown plan as misguided and called for a quick decision on troop levels after 2014.
"This accelerated drawdown of troops in 2013 will be very unhelpful and will have far-reaching negative consequences for the growth of Afghan security forces," said Hanif Atmar, an opposition leader and former interior minister, citing adverse effects on this year's fighting season and elections planned in 2014. "This decision runs against the advice of top NATO and Afghan generals."
Daoud Sultanzoy, a former parliamentarian who hosts a popular talk show, called the move "a typical Western response for a Western audience without taking into consideration Afghan realities."
"Come 2014, we'll have not only elections but an emboldened insurgency," he said, adding that troop levels next year "will send the wrong signal at the wrong time."
The drawdown plan approved by Mr. Obama would reduce troop levels to 60,500 by May 13 and to 52,500 by Nov. 13. The remainder would leave by mid-February 2014, a senior administration official said.
A senior administration official said this plan allows for "a sizable number of U.S. forces to support the Afghans for two additional fighting seasons before they are fully responsible for their own security" at the beginning of 2015.
Some defense analysts had expected Mr. Obama to announce the number of forces the U.S. intends to keep in Afghanistan after 2014, when the current mission ends.
Officials said reductions would continue after this year and throughout 2014. But the senior administration official said that Mr. Obama had made no decision on the long-term troop level, and would be making no further announcements in his State of the Union address, beyond the cuts to the force this year.
U.S. officials acknowledged that commanders will face a challenge of continuing to train Afghan forces while overseeing the extraction of tons of equipment and thousands of soldiers over the course of the year. But the command in Afghanistan has put in place plans to speed the withdrawal while continuing training, a defense official said.
Mr. Obama has said the mission of any forces remaining after 2014 will be limited to targeting the remnants of al Qaeda and high-level training of the Afghan security force. The U.S. is continuing to negotiate a long-term security agreement with the Afghans.
Although military officers had been advocating as many as 15,000 forces to remain long term, many senior administration officials favor a much smaller force, of between 3,000 and 6,000, officials said.
Defense ministers from the North Atlantic Treaty Organization are due to meet in Brussels later this month to discuss plans for this year's troop reductions. The officials are also likely to talk about how many troops they may contribute to Afghanistan after 2014.
—Maria Abi-Habib in Kabul
contributed to this article.

domain: news


The Things we Keep
by Zoe Byszynski
In my room, in my closet, on my shelf, in a box is my time capsule. I created it at the start of the pandemic and promised myself I wouldn’t open it until graduation. Over the years I’ve added ticket stubs, birthday cards, gum wrappers, and other treasures lost to my short-term memory. Outside the box, outside my closet, and in my room, similar treasures line my walls, shelves and desk. Photos of friends, broken bracelets, dried flowers. Nothing useful, nothing unimportant.
Throughout our lives, we accumulate and hoard. The small everyday objects that we don’t think twice about, suddenly become so significant when we threaten to throw them away. (That, or we’re all due for a little spring cleaning.)
Caroline Urdina, a senior film major from Frank Sinatra School of the Arts (FSSA), also keeps a memory box. Inside her box, she keeps a Gelato spoon from a date with her boyfriend.
“Keep the small things, even if they’re stupid. I’ve been told so many times by my mom to throw it out and my brother’s like ‘That’s gross’ but I don’t care because if it means something to you, that’s all that matters,” Caroline says. “I don’t plan on ever getting rid of it. Even if we’re not forever or if we’re together a hundred years in the future, I don’t care. It’s very special.”
Nicholas Rimalovski, a senior vocal major at FSSA, keeps a baseball glove from his first ever season, when he was only four years old, given to him by his grandfather. He leaves it by his other baseball belongings, as a reminder before he plays for the Frank Sinatra Legends baseball team.
“Baseball has always been like a big part of my life. It’s been kind of an escape for me. The two and a half hours on a baseball field, nothing else really matters, because I’m playing a game. And the outcome is what matters to me. And it just reminded me of where I got that hobby, that release from, and to maintain that dedication because it just reminded me that I’ve been doing it for that long. It’s not just something that I picked up on a random Friday afternoon. I want to be reminded, especially now that it’s my last year playing high school baseball, of how long I’ve been doing it,” says Nick.
FSSA senior film major, Lucy Karp, has a fishbowl from Israel that also serves as a reminder of personal change and growth. It was one of her first purchases on her solo trip to Israel last summer.
“I think that before I wasn’t really connected to Israel and my Judaism, but going there alone and buying something that was reflective of my trip and everything I learned on that trip was very transforming. I think I’m a much more independent person now,” says Lucy.
It’s the memories we make with the objects that are important, rather than the objects themselves. They serve as reminders of how we’ve changed from who we were when we received the objects
As senior year is coming to a close, and the bittersweetness of goodbye starts to form on my tongue, I look at all that I have to leave behind and choose carefully what I keep. No college dorm room is big enough to keep the memories of the four most defining years of my adolescence. When we reach the point where we can no longer turn back, but only look around, what’s the best rearview mirror?
Perhaps the answer is with someone who’s already taken the journey out of school, into undergrad, into the workforce and has found himself right back where he started. Patrick Thompson Jr., better known as PJ, is an alumni of Frank Sinatra who graduated in 2016 as a Film Major and crewmember. Now PJ works with his old teacher, Andre Vazquez, FSSA’s Assistant Production Manager.
PJ received an engraved leatherman from Andre as a departing gift to all the senior crewmembers.
“It’s a reminder that everyone who has one of those is kind of connected at a level that isn’t really gonna go away. To me, I feel like memories fade and items become useless eventually. But I think just taking the time that you had with you, taking the changes that you went through and the person you became through experiences, taking that with you is more important than any item or idea in my head. I think just learning to take change with you anywhere you go and continue to grow, taking that mindset,” says PJ.


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After 25 years in the corporate world, I decided to head back to the campus. In a way, I hadn’t really left since my dissertation. I had published several refereed articles in academic journals, five academic books (one a best seller in the field) and had conducted large research studies, collected a lot of data, written “white papers” and shared a good deal of that with my academic friends.
I found a position in the business school of a well-known Midwestern university. In my first semester I was asked what my political associations were. The question seemed irrelevant. I said so, adding that in presidential elections I had voted for three Independents, three Democrats and three Republicans. I was a free market guy, believed in lower taxes, less regulation, individual performance and personal accountability. I also believed in a secure retirement, health care support for the needy, a social “safety net” for those who could not work, education for everyone starting in kindergarten, a strong national defense, a sustainable ecological future for our children and grandchildren, smaller government, more local control, law enforcement – in short, sort of a libertarian, and one who believed in helping those who were less fortunate.
Continue reading “Why Was I Unfit?”
By Mark Bauerlein
If you browse through the list of dissertations filed in American literary and cultural studies last year, you will find many conventional and sober projects that fit well with traditional notions of humanistic study. Here are a few sample titles:
– “Rethinking Arthur Miller: Symbol and structure”
– “Tragic investigations: The value of tragedy in American political and ethical life”
– “Reading and writing African American travel narrative”
– “From demons to dependents: American-Japanese social relations during the occupation, 1945-1952”
– “The culture club: A study of the Boston Athenaeum, 1807-1860 (Massachusetts)”
But amidst these works, you also find a fair portion of projects with titles that border on the bizarre.
– “The fluviographic poetics of Charles Warren Stoddard: An emergence of a modern gay male American textuality”
– “Transperformance: Transgendered reading strategies, contemporary American literature”
– “Cruising and queer counterpublics: Theories and fictions”
– “‘Skirts must be girded high’: Spaces of subjectivity and transgression in post-suffrage American women’s travel writing”
– “Roddenberry’s faith in ‘Star Trek’: ‘Star Trek”s humanism as an American apocalyptic vision of the future”
– “Exhibiting domesticity: The home, the museum, and queer space in American literature, 1914-1937”
– “From sodomy to Indian death: Sexuality, race and structures of feeling in early American execution narratives”
– “The sentimental touch: Hands in American novels during the rise of managerial capitalism”
Continue reading Research As Self-Branding

domain: library


5612 County Rd 48 is aland property for lease in Okahumpka, FL.
The opportunity is to acquire a 127.93± acre property that is planned for 429 residential units in Okahumpka, FL. The proposed product mix calls for 239 single family lots and 190 townhome lots. This property has substantial topography for Florida which grant beautiful views of Lake Harris. The property is contiguous to Legacy of Leesburg, a 999 unit, active adult community in the heart of the Leesburg 55+ and is near Highland Lakes & Arlington Ridge, both 55+ communities
on US 27. The property currently consist of vacant groves, multiple mobile & single family homes, native pasture, and planted
hardwood trees. There are remnants of a previous agricultural use that has been abandoned. The site has been rezoned and was planned for residential development.
Location: The parcel is located on the south side of County Road 48, approximately 1.5 miles east of U.S. Highway 27, in
Okahumpka, FL. The property is a short 45 minute ride away from Orlando International Airport via the Florida Turnpike.
Access: Access is good from the Florida Turnpike, which is to the west of the parcels.
Size: 127.93± gross acres, of which 113.92 are considered uplands
Zoning: The property is zoned PUD and was approved for up to 429 residential units.
Tax ID #: 1208645, 1208661, 1208696, 1208742, 1301882, 1780101, 2616396, 3562348, 3562356, 3830068 & 3830072
Request Property Information
Please describe your commercial real estate requirements. We’ll introduce you to local properties that match your criteria.


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Customer Financial Protection Bureau Director Richard Cordray, center, listens to feedback within a panel conversation in Richmond, Va. in March 2015. Steve Helber/AP
New guidelines would need loan providers to make sure customers can repay loans
Arguing payday and auto-title loans trap borrowers in a вЂњcycle of financial obligation,вЂќ federal officials today proposed new limitations to clamp straight straight down regarding the lending industry that is thriving.
The buyer Financial Protection Bureau guidelines would when it comes to time that is first lenders to make a plan to make sure consumers have actually the methods to repay loans they remove.
вЂњToo numerous borrowers looking for a cash that is short-term are saddled with loans they can’t manage and sink into long-lasting financial obligation,вЂќ CFPB Director Richard Cordray stated in a declaration.
вЂњItвЂ™s much like stepping into a taxi merely to drive across city and choosing yourself stuck in a ruinously expensive cross-country journey,вЂќ he said.
In accordance with the CPFB, typical payday advances of $350 fee a median annual rate of interest of 391 %. Although the loans are created to be paid back quickly, four away from five are extended, which Cordray called a вЂњdebt trap.вЂќ One out of five people defaults on payday advances, he stated.
Payday and lenders that are auto-title usually the loan provider of last option. The industry contends it offers an essential economic service to individuals who canвЂ™t simply just take a bank loan out or get credit if they need fast cash.
But consumer advocates plus some state regulators have very long argued that payday and lenders that are auto-title small work to confirm a borrowerвЂ™s power to repay the loans, even when state regulations require it. A 2015 Center for Public Integrity research discovered that some auto-title loan providers authorized loans with terms that took over fifty percent the borrowerвЂ™s month-to-month income, for example.
Underneath the proposed CPFB rules, loan providers must figure out if a debtor are capable of the re payment whenever it is due and nevertheless cover basic cost of living and major obligations that are financial. The guidelines additionally enable just two extensions of that loan.
Lawmakers protect name loan companies while borrowers spend sky-high interest levels
Center asks Virginia Supreme Court to create public automobile title-loan documents
Corday called the regulations вЂњmainstream, common-sense financing requirementsвЂќ and stated the newest guidelines would вЂњprevent loan providers from succeeding by creating borrowers to fail.вЂќ
In accordance with the CFPB, the payday industry took in charges of $3.6 billion in 2015 running nearly 16,000 shops nationwide. About 50 % the states enable borrowers to pledge a motor vehicle name as security for short-term loans, frequently at rates of interest that may top 300 %. Lenders can, and quite often do, seize and sell down automobiles whenever borrowers are not able to spend. The CPFP has stated that about one out of five individuals lose their vehicles after defaulting.
The CFPB is searching for comment that is public the proposition until Sept. 14.
The proposed guidelines represent an important push that is federal overseeing the controversial industry, which includes mainly succeeded in fending off stricter lending laws and regulations in the us.
The guts for Public Integrity research discovered that name loan providers have actually beaten back reform legislation behind vast amounts in campaign contributions to mention legislators and also by aggressively regulators that are challenging seek to rein them in.
Three title that is major, their owners or key https://badcreditloanslist.com/payday-loans-mo/ professionals, pumped simply over $9 million into state governmental campaigns in the last ten years while they lobbied to destroy bills that hindered their operations. Since 2011, about 150 bills to cap rates of interest or break straight down on financing abuses passed away in 20 state legislatures, the Center discovered.
In Virginia, in which the three big loan providers spread about $1.5 million in campaign money in the final decade, five reform bills died in 2015 alone.
Virginia officials likewise have limited general public use of yearly company reports name loan providers file because of the state. The reports consist of detail by detail product sales figures, number of loans, interest levels charged on loans and defaults, in addition to how frequently the loan providers enter trouble with regulators.
Three giant automobile name lenders вЂ” TitleMax of Virginia Inc.; Anderson Financial Services LLC, conducting business as Loan Max; and Fast automotive loans Inc. have argued that disclosure would harm their organizations.
The Virginia Corporation Commission, which oversees corporations into the state, has sided using the name loan providers. In the Center filed a notice of intent to appeal the corporation commissionвЂ™s decision to the Virginia Supreme Court april.
Read more in Inequality, chance and Poverty
Trump, Wall Street and also the вЂbanking caucusвЂ™ willing to tear apart Dodd-Frank
President Trump said he can вЂdo a huge numberвЂ™ regarding the 2010 monetary legislation legislation


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Split Photography Location – Walk through history An ancient fortress by the Mediterranean Sea once home to a Roman Emperor, Split’s Diocletian Palace is a mighty sight.
Where to take the Best Photos in Manarola, Cinque Terre A rainbow of colourful buildings look out over the Mediterranean Sea as they sit perched high on rocky cliffs.
I’ve been keeping this project a secret for a few months now while I worked out the nitty gritty but it’s finally time to share with you what I’ve been busy dreaming into reality… The Wandering Lens is about to embark on an adventure photographing the European Coastline from the sea.
Florence Photography Locations Your guide to finding the best vantage points and photo spots in Florence… Terracotta roof tops, hidden courtyards and streets alive with historical features.
Pretty doesn’t begin to describe the Tuscan town of Siena. Perched on top of a hill overlooking rolling green fields with the Tuscan sun glowing down upon it, this Italian wonder is listed by UNESCO as a World Heritage Site.
Glistening seas and glamour await you in the magnificent municipality of Monaco. Bathed in year round sunshine and sitting pretty on the shores of the Mediterranean Sea, Monaco is he kind of place you visit and dream about living.
Hohenschwangau is the gateway to a land of fairy tales. Nestled amongst snow covered forests its where horse drawn carriages transport visitors to the immensely lavish castles perched high upon hills.
If you find yourself in Italy, don’t skip Verona. Even if it’s just an overnight stop this gem is well worth the visit just to sit with your legs dangling over the walls of Piazzale Castel San Pietro and photograph as the sun sets over the entire city.
Please tell me I’m not the only adult first time skier to cause chaos at the ski slopes? As groups of four year old children zipped past me at what felt like the speed of Olympic downhill skiers, I stood awkwardly trying not to slip over whilst standing still.

domain: travel


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Hulu will lose its longtime CEO sometime in the next few months, but that’s not stopping the eminent distribution platform. They have announced a varied slate of new programs set to debut in 2013, with offerings ranging between original series and locally-distributed international series.
In total, nine new offerings have been unveiled, three original and six exclusive. The original series include a dark office comedy called The Wrong Mans, which should be similar to the platform’s Spy series. There is also a documentary series about sports mascots called Behind the Mask and a comedy series titled The Awesomes and co-written by Seth Meyers. Looks like Hulu has the celebrity writers needed to keep up with Amazon Studios’ comedy push.
As for the exclusive series, they continue Hulu’s international flair with 3 British series, a French series, and an Israeli series among the six new offerings. In addition, the six previewed series run the gamut from high-minded drama to lowbrow comedy. Dramatic offerings include French cop series Braquo and Israeli thriller Prisoners of War. Light-hearted shows include the animated Mother Up, starring Eva Longoria, and Pramface, a comedy about a teen mom. Somewhere in the middle, there’s British high school dramedy Fresh Meat and British Jersey Shore imitator The Only Way Is Essex.
The nine new shows prove Hulu is coming out firing on all cylinders. Despite Jason Kilar’s departure, the premium distribution engine seems primed to crank out twelve more solid months and improve on last year’s $700 million revenue.

domain: artistic


Editor’s Note: Medscape’s Coronavirus Resource Center has the most up-to-date COVID-19 news.
A new study found that the effectiveness of the COVID-19 vaccines was less effective in older patients. This suggests that booster doses may be required to protect patients for the long-term.
The same was the case for the group of US veterans, with an average age of 67 years. Also those who received “the Moderna vaccine consistently had lower levels of antibody, when compared to recipients of the Pfizer BioNTech vaccine, across all age groups and time between vaccinations,” Kristina L. Bjema, MD of the CDC’s COVID-19 response team, and their colleagues.
The effectiveness of the Moderna vaccine was 89.6 percent at 14 to 119 days after patients had received the second dose, compared to 86.0 percent for the Pfizer vaccine. After 120 or more days, the vaccine effectiveness had dropped to 86.1 percent for Moderna and 75.1% for Pfizer as reported by the investigators in the Morbidity and Mortality Weekly Report.
The levels of the relevant antibodies, such as anti-spike immunoglobulin IgG and anti-receptor bindingdomain (RBD IgG), showed the same pattern. They were lower after the 120-day mark for each vaccine, however they were higher at both the Moderna and Pfizer time frames. These differences in antibody levels are in line with other studies, according to researchers and could be the result of the Moderna vaccine’s higher antigen content and its longer interval between doses.
All veterans of 1896 who participated in the study were included as they were being treated for COVID-like illnesses at five Veterans Affairs medical centers across the country (Atlanta and Houston, Los Angeles, New York City, New York City, Palo Alto, California). The group comprised patients who tested positive and those who were not positive for COVID-19 at the time they were first hospitalized. 799 of them eventually were fully vaccine-free. The average age of 58% participants was 65 years old or more.
Both vaccines were more effective in younger patients: 89.4% in the Pfizer group for patients who are less than 65 years of age, and 72.9 percent for those aged 65 and older in the Pfizer group. This is in contrast to Moderna’s 94.5 % and 78.6 percent. Researchers observed that both groups experienced the same decline in effectiveness after 120 days.
The effects of aging can be cause for concern.
“Overall for both vaccine products the levels of antibodies in this group of older US veterans with high prevalences of underlying medical conditions were significantly lower than those observed in healthy, younger volunteers or healthcare personnel in other studies,” they said, noting that booster doses could be needed “to provide long-term protection from severe COVID-19.”
For more information, follow Medscape on Facebook, Twitter, Instagram and YouTube.
Content Source: https://www.medscape.com/viewarticle/964635?src=rss


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A cyclist in California got a big surprise as he rode through traffic – among the vehicles he passed was a black SUV that had been stolen from his wife. The woman at the wheel fled the scene, but was caught by witnesses.
It was caught on mobile phone by Matthew Santoro, who happens to have more than 580,000 followers on Twitter and 6 million subscribers on YouTube, and who was in a passing vehicle.
So this just happened.
This guy just stopped traffic because he found his wife’s stolen car. The woman driving it ran off. This happened in Venice. If anyone knows how to get this to the authorities please send them this video. pic.twitter.com/U3bWYe7lRU
— Matthew Santoro (@MatthewSantoro) May 19, 2018
His footage shows the cyclist on the phone, presumably to the police, with his bike propped against the front of the car to prevent the driver from making off in the vehicle – not an easy task, given the traffic.
Instead, while he was mid-call, she started to walk off at a very brisk pace but was chased down by witnesses.
The woman, 39-year-old Erica Puig, now faces charges of grand theft auto, according to the Los Angeles Police Department, who confirmed that the vehicle had been stolen from Santa Monica.
Afterwards, Santoro said on Twitter: "We captured it and the LAPD retweeted it, and they DM'd me and said thank you for basically capturing somebody."
Born in Scotland, Simon moved to London aged seven and now lives in the Oxfordshire Cotswolds with his miniature schnauzer, Elodie. He fell in love with cycling one Saturday morning in 1994 while living in Italy when Milan-San Remo went past his front door. A daily cycle commuter in London back before riding to work started to boom, he's been news editor at road.cc since 2009. Handily for work, he speaks French and Italian. He doesn't get to ride his Colnago as often as he'd like, and freely admits he's much more adept at cooking than fettling with bikes.


Sarah Dickenson, editor l photographer
Sarah is a lifestyle photographer, traveler, and foodie with a keen eye for design and a love of street style! She hopes to use the FWORD to share the stories of creative and inspirational people in the desert community of Palm Springs!
You can see more of Sarah's work here!
Follow Sarah's daily adventures on instagram @sarahldickenson


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A spokesperson for the Oklahoma Department of Health says Interim Director Preston Doerflinger resigned effective immediately.
The DHS board met Tuesday.
Doerflinger submitted his resignation to the board.
In the resignation letter Doerflinger said, "Effective immediately, I resign as Interim Commissioner of the Oklahoma State Board of Health."
Board president Martha Burger said an immediate search for a commissioner would begin:
“Hopefully we will have candidates ready to vet in 30 to 60 days and have an interim commissioner in place shortly after that time.”
Brian Downs was named as the acting replacement.
Downs said the department has a strong leadership team in place that is committed to the agency reorganization currently underway.
“We have a dedicated leadership team that is committed to get OSDH back on sound financial footing,” said Downs. “Our entire organization remains focused on protecting the health of all Oklahomans and restoring confidence in this agency.”
Governor Mary Fallin released a statement on Doerflinger's resignation Monday:
“The board of the Oklahoma State Department of Health has accepted the resignation of Preston Doerflinger as interim commissioner. He has also resigned as secretary of finance, administration and information technology.
“Preston has played a critical role in state government, serving as director of the Office of Management and Enterprise Services, and Cabinet secretary of finance, administration and information technology. During the past seven years, his efforts saved tax dollars by implementing cost-saving reforms and consolidating state agencies. He also helped guide the Department of Human Services during a critical time when key reforms, such as the Pinnacle Plan, were implemented. I appreciate his service to the state.
“I was unaware of the personal situation involving Preston and his ex-wife almost six years ago. Mrs. Doerflinger did not contact my office about this matter. I take domestic violence very seriously, but I will take Mrs. Doerflinger at her word that this matter was not a case of domestic violence. I respect Preston’s decision to move on from his government service, and wish him and his family the best.”
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From Wikipedia, the free encyclopedia
Mont d'Or (from French: "golden mountain") may refer to:
- Mont d'Or (cheese), a type of cheese
- Mont d'Or (Alps), a mountain in Switzerland
- Mont d'Or (Jura Mountains), a mountain in France
|This disambiguation page lists articles associated with the title Mont d'Or.
If an internal link led you here, you may wish to change the link to point directly to the intended article.

domain: geography


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|Contributions||University of Toronto. Faculty of Law|
|The Physical Object|
|Pagination||202 p. ;|
|Number of Pages||202|
Jan 07, · Secured Transactions book. Read reviews from world’s largest community for readers. This informative student guide offers: proven Examples & Explanatio /5(27). Lessons by Subject Outline - Secured Transactions This Subject Outline allows you to search for terms of art that correspond to topics you are studying to find related CALI Lessons. Subject Matter Outline. Secured transactions; Secured transactions Primary tabs. Secured Transaction Law: an overview. A security interest arises when, in exchange for a loan, a borrower agrees in a security agreement that the lender (the secured party) may take specified collateral owned by . If your book is not shipped back to us by your rental due date of your rental period, you may automatically be charged an additional 10% of your rental as a late fee. If your book has still not been shipped back to us by the 14th day after the due date of your initial rental period, you may automatically be charged the “buyout price”.
Once you pay the buyout price of a book, it becomes your property. If you have not returned the book by the due date and we are unable to charge your credit/debit card, it is your responsibility to pay the fee immediately. You will be notified via email if your credit/debit card was declined. Sep 26, · By depicting what happens in transactions through illustrations, it allows students to tap into their own experiences and attempt to understand the Author: Lawprofblawg. The trickiest part of studying the UCC is not understanding the Code sections, but applying them correctly. Now there is a way to illuminate the concepts and principles underlying Article 9 - James Brook's SECURED TRANSACTIONS: Examples & Explanations. This thorough paperback meets the student's need for practice in applying the Code. Through a series of carefully crafted examples that . Parkinson Disease ( Questions & Answers) Questions and Answers: Remedies (Questions & Answers) Secured Transactions (Quick Study: Law) Examples & Explanations: Secured Transactions, Sixth Edition Availability of Credit and Secured Transactions in a Time of Crisis Secured Transactions: Prenotes, Cases, & Problems (Commercial Law Book 1) Selected.
The ABCs of the UCC Article 9: Secured Transactions, Third Edition By Russell A Hakes An introduction to the law governing security interests in personal property, this book explains the terminology, structure, and methodology of security interests governed by Article 9. Jun 30, · This Understanding treatise provides students with an analysis of the underlying rationales of Article 9 of the Uniform Commercial Code, the federal Bankruptcy Code as it relates to Article 9, and other relevant state and federal legislation. Familiarity with these rationales is critical for a true understanding of the law of secured transactions. The organization of this/5(13). Here are some links to (free) Secured Transactions Multistate Essay Exam questions and National Conference of Bar Examiners (NCBE) point sheets. (If you would like to purchase a book of Secured Transactions MEE questions and NCBE point sheets, check out our MEE books here. The premier authority on secured transactions, Secured Transactions: A Systems Approach is known for its cutting-edge coverage, dynamic pedagogy, and ease of use for instructors. The Systems Approach gives students the big picture.

domain: law


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Shot in the city of Kolkata, India. An old moon-faced woman was looking at my camera straightly. Although her hair was messy, her eyes had a power and her lips were pressed into a thin line.
The boy I met in the street rose to his full height and looked straight showing a smile of…(more)
A boy was sitting by the wayside. When I focused him he leaned back while his lips were pr…(more)
A boy wearing a tank top was looking straightly with his pure eyes. Little by little his f…(more)
Two young boys stood close together in front of my camera. Stone-like expressions were on…(more)
The boy was tending a store. When I focused him, he looked at my SLR camera with a proud e…(more)
A little girl with a moon face was sitting in the shade on the riverbank with some adults.…(more)
Shot in the city of Pune, India. The round-faced woman was selling by the wayside.
Two women and a man was working at a construction site. A moon-faced man was cheerful and…(more)
When I strolled about the street in residential area, I felt like I was being watched. And…(more)
A car came and stopped at the crossing. Its window was opened. And I saw some boys sitting…(more)
Shot in Shinjuku Gyoen Park. There are some stone lantern by the wayside of the park.
Shot in the riverbank of Tama River. A young man was relaxing under the bridge.


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6:05pm - 7:05pm
ONLINE via Airmeet
Psychedelic Intimacy: Qualitative Exploration of Psychedelic States in Romantic Relationships
Psychedelics are consumed in many different settings, but one is almost neglected by psychedelic research: Taking psychedelics as a romantic couple. MDMA was used for couples therapy in the 80s, while contemporary research describes how couples are consciously consuming MDMA to work through relationship issues and reconnect with their partner. The revival of psychedelic research in the last decade has highlighted many therapeutic applications for individuals, but what about couples? Can their ﴾perceived﴿ relationship quality and intimacy benefit from a shared psychedelic experience? Based on the available literature the answer to those questions is a resounding “we don’t know”, a classic research gap. This qualitative study explores the effects of altered states of consciousness ﴾induced by classic psychedelics﴿ on relationship quality and intimacy in romantic couples. Multiple couples were interviewed using semi‐structured interviews to learn more about their reasoning behind taking psychedelics together, what they expected from this experience, and how it affected their relationship. Both partners were interviewed together for one hour or more. The technique of simultaneous interviewing is not used very often but has clear advantages; Differences in interpretations can be addressed within the interview and couples are able to construct a coherent narrative about their shared experience. Thus, the qualitative inquire puts the emphasis on the couple rather than comparing two individual experiences.
The interviews were transcribed, and thematic analysis was used to identify key themes of this dyadic experience and its consequences for the relationship. The dyadic psychedelic experiences are then compared to similar experiences of couples taking MDMA together. Implications for further research are discussed. It is important to highlight how this study can inform future plans for psychedelic‐assisted couples therapy. The qualitative study also provides a glimpse into the practices of couples, who are taking psychedelics together in a responsible manner. This practice of “psychedelic intimacy” can be described as distinct from couples who are taking psychedelics for purely recreational reasons.


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Travel with Peta Mathias on a culinary journey through Vietnam. With more than 20 recipes, this book is designed for the armchair traveller and for anyone who wants to know more about Vietnamese food and culture.
Exisle Publishing Pty Limited
A journey through Vietnamese food and Culture
Education & Reference /

domain: food


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The National Australia Bank has confirmed it was the primary institution which processed a toxic batch of direct debit transactions on Monday that emptied the bank accounts and maxed out the credit cards of many RACV customers, some to the tune of $50,000.
As the high severity payments disaster rolled into its fourth day, iTnews can reveal that it was NAB’s merchant acquiring arm that ran a transactional file supplied by RACV to its end, allowing a slew of erroneous deductions to go through – sometimes hundreds at a time for individual accounts.
“We’ve been working hard with RACV to quickly resolve this issue and process the refunds for affected customers as quickly as possible. In fact, many customers’ accounts have already been corrected,” a NAB spokesperson told iTnews.
Ironically, it will be NAB's account holders who will be able to access their refunds first because they will land directly rather than taking time to clear through the complex web of bilateral interbank links.
The incident is being closely watched by regulators because of the high degree adverse impact on consumers that has ensued.
Many affected RACV customers have been belatedly told by the besieged insurer that they will have to wait as long as five days for refunds to be made available, despite being initially told all refunds had been processed.
“Five days to be refunded, what an absolute joke. No money in the bank for food, petrol and most importantly mortgage. And no compensation coming our way, bloody disgraceful RACV !!” said one poster to Facebook.
The remedy for customers whose credit cards limits were blown by RACV’s dud file is even more complex because of the complicated nature of reversing payment authorisations.
It is understood that while NAB ran the defective file from RACV through to completion, it was the bank which first detected the problem and then moved to run refunds, contacting RACV in the process.
Part of the issue appears to be that batches that once rolled across the night now process far more quickly, thus making it far more difficult to stop and correct a run mid-stream.
However many crucial questions about the incident remain unanswered or unresolved, including the total number of accounts affected or the total dollar amount of funds wrongly debited.
A major headache for affected RACV customers, as well as banks and credit cards dragged into the debacle, is now sorting out the raft of loan and mortgage default penalties, overdraw fees and negative credit ratings impacts that will hit customers wrongly cleaned out of funds.
RACV has refused to publicly disclose key details around how many of its two million customers were hit by the incident, nor if it has extended emergency financial assistance to affected customers. Instead, the insurer has maintained it is dealing with clients’ needs on a case by case basis.
Customers, who have taken to social media, remain angry and critical over RACV’s handling of the situation, especially the lack of disclosure and detail as well as lengthy call centre waiting times when they have been left broke and stranded.
The high profile incident has also strained between RACV and NAB and is likely to complicate the insurer’s relationship with banks going forward.
It is understood that RACV’s merchant acquiring account was put up for pitch to other institutions before the incident occurred, a slab of business that will now likely be less appealing in terms of price because of its potential for reputational loss.
Merchant acquiring, where banks essentially collect and process payments for businesses, has become an increasingly commoditised space over the past decade as margins and processing fees continue to fall.


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The single most powerful catalyst for stirring up, over time, vindictive anger in the perpetrators of school and public violence is the process of bullying.
As I noted in a previous article concerning the effect of digital media on teenage minds, let me draw in a common denominator in school violence: bullying of a disturbed mind. The ongoing effect of bullying on an already disturbed mind can develop into tragedy of such horrifying scope that it unfortunately hits national news!
In a study by Peter Langman Ph.D. in 2014 of the then 48 school shooters, 18% were psychopathic, 44% were psychotic and 75% had been traumatized in life. Of the same 48 shooters, many of them were bullies themselves. Of the shooters who were bullies themselves, 94% were psychopathic, 48% were psychotic, and 17% were traumatized. It's possible as in sexual abuse the abused eventually became abusers. Of the 48 shooters there is little evidence that they went after anyone who had bullied them. The horrific acts of their violence to anyone in their murderous plans, however, show an internal rage and vindictive anger.
Langman went on to say that it was very hard to evaluate how much and how often the shooters had been bullied. However, it can be easily documented and proven that 40% of the shooters had been clearly bullied. More than 40% could have been, it was just not as easily proven. As he noted, some could have been traumatized earlier in life by bullying which went unreported.
Many teens are troubled because they are growing up in a single parent home, or being raised by grandparents, a growing trend in America. Not only are they being bullied but they are often being rejected by potential girlfriends or boyfriends. They are troubled by a world in turmoil, troubled by other peer pressures, troubled by conflicts with schoolteachers and administrators, troubled by the loss and the lack of any kind of security in life, and troubled about being troubled!
Try to imagine that you open up Facebook on your phone. You look at your friends list, which you have developed over time. You know that you don't have any close friends. The people on your list are really just people you know from school.
You see that they are posting comments on your Facebook wall about a nameless certain someone." You see mockery, laughter, jokes, and criticisms about appearance, clothing, and family situations. It is very obvious they are talking about you. You are horrified, terrified, rejected and deeply hurt. Everything within you wants to try to answer back to their painful criticisms but you have learned the hard way it is best to try to ignore it. Now try to imagine this happening to you over and over again! To the already troubled or disturbed mind, this is a recipe for violence and disaster.
Bullying is unwanted, aggressive behavior among school-aged children which involves a real or perceived power imbalance. The behavior is repeated, or has the potential to be repeated, over time. Both kids who are bullied and who bully others may have serious, lasting problems. In order to be considered bullying, the behavior must be aggressive and include:
An imbalance of power: Kids who bully use their power—such as physical strength, access to embarrassing information, or popularity—to control or harm others. Power imbalances can change over time and in different situations, even if they involve the same people.
Bullying includes actions such as making threats, spreading rumors, attacking someone physically or verbally, and excluding someone from a group on purpose.
For the troubled mind affected by other emotional or psychological disorders, being bullied can trigger some very negative emotions. Readers, the way you and your classmates dealt with conflict was far different than the way it is dealt with today. If you and perhaps your friends back then decided out of fun to pick on someone it perhaps was met with strong language and a fistfight followed. However, today's teenagers witness 200,000 acts of violence though television and media by the time they are 18 years old.
There are three types of bullying:
- Verbal bullying is saying or writing mean things. Verbal bullying includes:
- Inappropriate sexual comments
- Threatening to cause harm
- Social bullying, sometimes referred to as relational bullying, involves hurting someone's reputation or relationships. Social bullying includes:
- Leaving someone out on purpose
- Telling other children not to be friends with someone
- Spreading rumors about someone
- Embarrassing someone in public
- Physical bullying involves hurting a person's body or possessions. Physical bullying includes:
- Taking or breaking someone's things
- Making mean or rude hand gestures
It is interesting to note here that when a Christian retired college professor sought to have a public forum on the topic of bullying in our city, he was met with opposition! It is not usually called bullying when it is done by adults; it's called favoritism or can be a type of nepotism. It involves flattery. It is a control tactic often used in the business world to manipulate people into or out of a favored position.
It is so important for teens in the schools to be proactive in the defeat and undoing of any bullying they see. We need to teach them that if they see someone being put down verbally, find ways to build them up! They need to remind others that they will not tolerate bullying at any level! As they deal with bullies themselves they need to be aware that they may be dealing with someone who was originally rejected as a child, and in their quest for acceptance may have gotten twisted into someone who sees him or herself strong and in control.
Teens should also learn that if they don't know what to do, they should pray because it may be time for some alone time with Jesus. It is His unexplainable supernatural love, which reaches into lost lives and can change them into the saints of God!

domain: psychology


[Salt Lake City, 08/09/2017] — JayLynn Photography Studio offers senior photography services to teenagers who want to capture their high school senior year moments. The company’s photographers will keep the photo shoot professional and fun so that teens will enjoy striking poses and dressing up to mark their final year in high school.
Offering Competitive Prices to Senior Students
JayLynn Photography Studio understands the importance of creating beautiful keepsakes, which is why it provides a competitive rate on its photography services for senior students. The session rate, which includes a 90-minute shoot with a photographer, is from $25 to $75. The Salt Lake City-based studio wants to keep its services and packages fair and within reach, as it wants its clients to cherish their senior high school pictures through the years.
Helping Teenagers Represent Their Personalities
The studio aims to make the photo more enjoyable and authentic for its teenage customers. Thus, it encourages its clients to bring any accessory they want for the photo shoot. They are free to pose with a guitar, wear sports equipment, or put on anything that they feel would represent their personalities in the photos. On top of their accessories, the studio would also provide a wide range of props to help them compose their creative scenario. Additionally, teenagers who would like to have a makeover before the photo shoot may take advantage of the studio’s makeover services for $25.
About JayLynn Photography Studio
The studio takes a unique approach in all of its photography projects to satisfy the diverse needs of its clients. It has a team of flexible, professional photographers ready to capture the clients’ perfect moments. Additionally, it has specialists who can perform fine retouching and finish to each print shows a professional, quality look.
It does its best to ensure that every photo shoot is successful on all fronts, including the clients’ satisfaction during the process. It wants customers to leave the studio feeling proud and satisfied with the finished product.
Visit http://jaylynnstudios.com for more details.


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The 7th annual Jose Montaño Foundation 5K to raise cancer awareness
SAN DIEGO (KUSI) – The Jose Montaño Foundation is hosting its 7th annual 5K Walk Run to raise cancer awareness and give back to local kids.
The foundation was started in 2013 when Jose was 12 years old and battling brain cancer. Since then, the Jose Montaño Foundation’s mission has been to assist children battling cancer and support their families. The organization inspires students to excel at school and in the communities where they live.
The Jose Montaño Foundation 5K is taking place this Sunday, March 1st at Glen Abbey Memorial Park in Bonita. March 1st would have been Jose’s 19th birthday.
For more information, visit www.JoseMontanoFoundation.org.


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Sunday News #47
I’m finally starting to feel more like myself again. I thought I was ready to blog in February. However, due to some lingering symptoms from the antibiotics I was taking, I just didn’t feel up to doing much. Fortunately, I no longer need to take the antibiotics and I’m feeling less nauseated, dizzy, and headachy.
Sorry I didn’t comment on everyone’s posts last time. I really want to read and comment on other blogs. I’m just trying to get back in the habit now that I’m feeling better. Please bear with me.
I haven’t blogged since February 5 so nothing to report.
I finally read something this past week! I read THE IT GIRL by Ruth Ware and I’ll be posting my review tomorrow. I’m going to start reading THE LAST ANNIVERSARY by Liane Moriarty some time today.
I also finally finished listening to the ECLIPSE audiobook. I started listening to it last November. However, since I usually listen to audiobooks in my car and I didn’t really get out for while, it took me a while to finish.
I honestly haven’t listened to a lot of music this week because I focused on listening to the ECLIPSE audiobook. I did, however, listen to “Grace Kelly.” I first listened to the chorus sung by Ryan Reynolds and Will Ferrell. Afterward, I listened to the original full song by MIKA because I’d never heard it before.
Corey and I are currently watching THE LAST OF US on HBO Max. We’re really enjoying the premise and characters. We also love the actors. We have a joke that Pedro Pascal likes to be in roles where he has to protect an orphan and help get them to wherever they need to go. LOL.
We’re also currently watching season 3 of STAR TREK: PICARD on Paramount+ and we love it so far. It’s fun to see the crew from The Next Generation in their different roles. I’m really excited to see where this season takes us!
We finally binged WEDNESDAY on Netflix. It was amazing! Jenna Ortega was perfect as Wednesday. I also loved her roommate at Nevermore. I also didn’t realize how tall Gwendolyn Christie is! We can’t wait for season 2.
We also saw the new Ant-Man movie, ANT-MAN AND THE WASP: QUANTUMANIA a couple of weeks ago when it first came out. I really enjoyed it despite its plot holes, which I didn’t notice while watching. Corey didn’t like it very much. He had way too many questions because of its plot holes. My favorite part was the second end credits scene, lol. If you’ve seen it, you can probably guess why.
I started bingeing THE VAMPIRE DIARIES this past week. I’ve always wanted to watch the series. I like it so far. I’m a couple of episodes into the second season. I really love the exploration of vampiric and supernatural lore. The only thing I could do without is the stupid love triangle. Because I’m required by love triangle law to pick a team *rolls eyes*, I guess I’m Team Damon. I love his character and I love that he’s portrayed by Ian Somerhalder.
I love The Fast and the Furious movie series. It’s one of my favorites, aka guilty pleasures. I know they’re way over-the-top and unbelievable, but I still love them, especially once they turned into heist movies.
The newest movie comes out in May and it looks like all the characters are returning for this one, even Brian (Paul Walker’s character). I’m very curious how they’re going to pull that off since Walker died nearly 10 years ago. One of my best friends loves the movies too so we started rewatching all the movies.
I want the two new TWILIGHT books announced by Stephenie Meyer in February to come out sooner rather than later. I’m really excited she wants to focus on characters other than the Cullens and wolves. I can’t wait to see what comes of this announcement. I also hope this means Meyer will finally return to THE HOST world since she originally planned to make it a trilogy.
I need to get some of my crocheting and knitting projects finished. My friend and I are opening an Etsy store. We both love making amigurumi (crocheted stuffed toys), afghans, beanies, and other things. We’ve always wanted to see if we can make money selling them on Etsy so we’re going to try. I’ll share a link to the store when it’s officially open.
How was your week? Anything exciting happen?
I am happy to see you are feeling better! And I knew of Mika’s rendering but Ryan Gosling and Will Ferell bluffed me here!!
Thanks, Sophie! 😀 I’m glad I could surprise you with Ryan Reynolds and Will Ferrell. LOL.
Glad you are feeling better and getting so active again.
Have a great week.
Thanks, Harvee! 😀 I hope you have a great week too!
How exciting! Congrats on your Etsy store!
I am glad that you are feeling better. And Vampire Diaries! We loved that show – I felt like I never knew what was coming. And I am Team Damon too, but Alaric is my favorite.
Thanks, Erin! 😀 My friend and I are really excited about the store. We can’t wait to do its grand opening.
I can see why Alaric is your favorite. From what I’ve seen of him so far, he’s a great character. 😀
I’m glad you are feeling better. It’s hard to do anything when you don’t feel well.
Congratulations on starting an Etsy shop. It sounds delightful.
So many people love the Stephanie Meyer books. I hope her new books are all that you wish for.
Thank you, Deb! 😀
My friend and I are really excited about your shop. We can’t wait until our grand opening.
Thanks! I know Stephenie Meyer isn’t for everyone and that’s fine. She helped get me reading so I’ll always be grateful to her. Even though her writing isn’t the best, I love her storytelling ability. I hope the new books don’t disappoint. 😀
Glad you’re feeling better! Congratulations on starting your Etsy Shop, I hope it’s a huge success!
Thanks, Vicki! 😀 We’re both really excited about out shop. We hope others are too.
So glad you’re feeling better and glad that you were able to read a couple books. Good luck on the ETSY shop, it’s a challenging endeavor. I just relearned to crochet after over 20 years away from it and am working on a throw. It’s fun to have something to do with my hands while watching TV. It doesn’t feel like such a waste of time. 🙂
Terrie @ Bookshelf Journeys
Thank you, Terrie! 😀 I’m glad I’ve been reading this week too. I’ve missed it.
That’s awesome that you’re crocheting again. I love doing throws. And, I completely agree about crocheting or knitting while watching TV. I love keeping my hands busy. I feel lest anxious because of it. 😀
Ah I love MIKA! Did you know we named our kitty after him? I can’t remember if you knew or not…
I knew you named your cat after a musician, but I didn’t know it was this MIKA. Awesome! 😀 I’m glad I know her namesake now, lol.
I somehow missed Midnight Sun and didn’t know MORE Twilight books were coming out. I loved the original books but I am seeing mixed reviews on Midnight Sun. Did you read it? What did you think? I have The Host on my bookshelves but have not read it either…exciting news about the Etsy store, good luck!
I loved MIDNIGHT SUN. Being in Edward’s head was truly enlightening. I loved learning more about him and the Cullens; the vampiric world; the Forks humans; Jacob; Charlie and Renée; and James, Victoria, and Laurent. I also loved knowing all the things Edward said to Bella that she couldn’t hear and knowing his reasons behind all his decisions and actions. It shed so much light on New Moon.
Other people didn’t like MIDNIGHT SUN because they felt it intensified Edward’s stalker behavior and Bella and Edward’s unhealthy relationship. Parents were especially concerned because of it not being a good role model for a healthy relationship for their teenagers. None of that stuff bothers me. Yes, I know their relationship is unhealthy AND it’s fiction. She’s in a relationship with a vampire! Of course it’s unhealthy.
OMG I love amigurumi!!!!! Can’t wait to see what pops up in your Etsy shop!!!!
Yay! 😀 I can’t wait to share what I’m making and what’s in our store! 😀
Glad you’re feeling better! And I really want to see Ant Man. Now you have me curious about the end scenes. I miught take a peek.
Thanks, Greg! 😀 I hope you like Ant-Man. I know a lot of people didn’t. I hope you enjoy the end scene, though, if you sneak peek it.
I am glad you are off the antibiotics finally and feeling better. It can take a while to get back into the swing of things, I know. I hope you enjoyed THE IT GIRL. I have read a few Ruth Ware books, but not that one. I’m glad I am not the only one who drags out audiobooks–more for lack of opportunity than anything else. Wednesday is great, isn’t it? I can’t wait till the second season too! I really liked Vampire Diaries (the television show–I didn’t like the book) and hope you enjoy it. I’m with you about The Fast and the Furious. Seeing some of those stunts and cinematography is impressive on its own, even as over the top as the movies are.
I hope you have a good week and month of March. Take care!
Thank you! I am too, lol. And, I really think I’ll be able to get back into the swing of things this time. 😀
If you read THE IT GIRL, I hope you enjoy it. And, yes, my audiobooks are always dragged out because of lack of opportunity. I very rarely listen to them because of that, lol. Yes, I loved the cleverness of Wednesday so much and Jenna Ortega was fantastic in that role. I’ve never read Vampire Diaries, but I am enjoying the tv show. I might give the books try someday. I’m so happy to hear that you love The Fast and the Furious movies. 😀
I hope you have a great week and month as well!
I’m so happy you’re feeling better! It’s good to have you back in the blogging world again
Thanks, Wendy! 😀 It’s good to back! I missed everyone!
So glad to hear you’re felling better! I had no idea there were more Twilight books coming. I doubt I will read them (I enjoyed the series at the time but I’m not really interested in returning to it) but I know that will have a lot of readers happy and excited. 🙂
Thanks, Tanya! 😀 I totally understand not returning to Twilight. A lot of my friends that I met on Twilight fan boards are also done with the series. I think the only reason I’m not is that the series helped get me to read. I owe Stephenie Meyer a debt of gratitude for that. 😀
Welcome back Jenni! I’m so glad you’re feeling better.
Thank you so much, Jodie! 😀
I’m delighted that you’re feeling better! Blogging and commenting should always be secondary to that. I really want to watch “Picard” but don’t have the streaming service it requires–like for so many programs I want to watch. I liked it when TV was free.
Thank you so much, Margaret! 😀 I know, right?! The cost of all these streaming services is outrageous. The only reason we pay for most of them is that we’re co-oping with some of our family and friends. We each take turns paying and share the services through different profiles. (I know the services wouldn’t be too happy knowing this.)
I am so glad to hear that you are on the mend and feeling better. I was wondering where you had gone. Welcome back!!!
We went to our first movie since COVID in a theater this week. It felt like the most normal thing I’ve done since early 2020.
Thank you so much, Anne! 😀 I missed everyone so much. I’m glad I’m finally feeling up to reading and blogging again.
That’s so awesome that you went to a movie in the theater this week. I hope you enjoyed the movie! 😀 Going to the movies was the thing I missed the most during the pandemic. We didn’t start going again until late 2021 and it was only for things like Marvel movies. We wear masks even though no one else does. In the beginning, we’d buy our seats and the ones adjacent to us as well to give us a small buffer.
I’m glad you ‘re feeling better. You get to all the comments whenever you can/ Believe me, we all get it lol
Did you watch Spirited (the movie Reynolds and Farell were singing in)? We liked it a lot. We’ll probably let Picard come out with all the episodes and subscribe for a month to watch.
Karen @For What It’s Worth
Thanks, Karen! 😀
I did watch SPIRITED. I loved it. I didn’t realize Ryan Reynolds could sing. (I know his voice isn’t the greatest, but it’s still better than I can do, lol.) I really loved the movies take on THE CHRISTMAS CAROL. I’ll definitely watch it again next year!
I have a friend who’s going to the same with Paramount+. Corey’s so excited about the Star Trek series that he’s too impatient to wait, lol. Also, the only reason we pay for most of the streaming services is that we’re co-oping with some of our family and friends. We each take turns paying and share the services through different profiles. (I know the services wouldn’t be too happy knowing this.)
Happy to hear you’re feeling better! It is hard to be motivated to do anything when you don’t feel good.
I had no idea Meyers was releasing new Twilight books! I’m excited to hear that!
Thanks, Rachel! 😀 I decided to google Meyer this last week because I was curious and I saw that article. I’m glad I did!
I can’t wait to see the new Ant-Man movie. I’m going to wait until it’s on Disney+. I don’t care if it has plot holes. I think I’ll still enjoy it. Lol. Good luck with your Etsy shop, but most importantly have fun with it! . I used to do beading and I had an Etsy shop for several years. I closed it a few years ago because I wasn’t enjoying the business side of things. I rarely do beading nowadays. I’m too busy reading! 🙂
I don’t mind the plot holes either. I usually don’t see plot holes until someone else points them out to me, which my husband did. It didn’t affect what I thought of the movie. LOL.
I’m sorry you didn’t enjoy the business side of things with your Etsy shop. I’m hoping it’s not to bad. I mostly just want to do it as more of a hobby side business than a real money-making business. Even though you’re too busy reading, if you want to bead any time in the future, I hope you do. 😀
So glad you’re feeling better! Antibiotics mess me up though thankfully I haven’t had to have them in a little while. I normally end up taking them with Zofran and still feel all out of sorts. I have the Ruth Ware book on my TBR. I really loved her first two books but than was a bit meh on the two after that but I’ve seen great reviews of her latest books so I think I need to give her another try. The Liane Moriarty looks really good. That’s another one on my TBR. Have a great week!
Thank you, Katherine! 😀 Sometimes, I take Zofran when I’m on antibiotics too. The problem is that if I take too much, it gives me headaches so I’m damned if I do and damned if I don’t. 🙁
If you do give THE IT GIRL a try, I hope you like it. I’ll have to give Ware’s first two books a try if you liked them so much.
I loved WEDNESDAY and can’t wait for another season.
Such a great show, isn’t it?! 😀
I’m glad you’re feeling better! Your “Feeling” and “Blogging” sections could have written by me except that I wasn’t sick; I just had internet problems and other priorities. I’m finding it so freaking hard to get back in my blogging/reading groove now though.
We’re currently working on the third season of Star Trek: Discovery but I requested the second season of Picard and it’s ready to be picked up at the library. So much Star Trek! My husband may rebel.
I’m not a binger by anyone’s definition, but my definition, we binged Wednesday too. Which means we watched the whole season in a month 🙂
Good luck setting up your Etsy store!
Sorry you’ve had such a hard time with your internet. Internet problems make me crazy. Ever since we moved last June, our internet has had problems. We had Google Fiber in our old place and I miss it, lol.
I love STAR TREK: DISCOVERY. I’m anxiously looking forward to season 5. 😀 I hope you enjoy season 3 and 4. Fortunately for me, my husband adores Star Trek. He could watch it all day every day.
I understand about not bingeing a lot all at once. I used to not binge TV shows because I didn’t have the time. Now, bingeing just cuts into my reading and blogging time. I’m going to try to balance them so I can do a little of everything. 😀
I’m glad you are feeling better.
I watched a couple of episodes of Wednesday and it’s good. I have to get back to that one. I really want to see the new season of Picard. I love that it includes so many TNG actors. This should be fun.
Have a great week!
Thanks, Yvonne! 😀 I hope you like the rest of WEDNESDAY. It’s one of my favorite new shows. I hope you get to watch the new season of Picard soon. 😀
I loved The It Girl and also The Last Anniversary. Enjoy all your books, and I hope you keep feeling better.
Thanks, Laurel! 😀 I’m glad you to hear you loved THE LAST ANNIVERSARY so much. I’m a huge fan of Liane Moriarty and I’m looking forward to reading it.
Glad to hear that you are feeling better! Hope you get back to where you want to be with blogging. Have a great week!
Thank you so much, Jamie! 😀
welcome back! i’m glad you’re feeling better!
i really need to watch the last of us. it’s hard to avoid all the spoilers on twitter.
Thanks so much, Chelsea! 😀 I bet it’s hard to avoid the spoilers. When I was more active on Twitter, I watched The Walking Dead and I always had to be careful if I wasn’t caught up with the episodes.
Glad you’re feeling back to normal! I’m excited about the new Twilight books as well. I enjoyed Ryan Reynolds and Will Ferrell in the Christmas movie they did last year. I still go around saying Good Afternoon whenever I’m mad at someone, lol. I’m enjoying The Last of Us too! Hope you have a good week!
Thanks, Lisa! 😀 Ha ha! Good afternoon was the best part of that movie. I need to remember to say that to people who piss me off too. Thanks for the reminder.
Glad your feeling better and feel like blogging a bit!
Thanks so much, Stormi! 😀

domain: entertainment


text:
More filler than plot
New Game!! episode three fails to keep the momentum built up last week. That said, the theme of inadequacy is once again explored, albeit in a different way. Unfortunately, it has more filler than the other episodes this season, and the main plotline doesn’t progress in any meaningful way.
Aoba is having trouble adjusting to her new role as character designer. Ultimately, although she is good at creating the characters, she knows very little else about the game design process. Early on, Aoba tells Hifumi to use a fur effect which looks good but causes severe lag. As the rest of the team brainstorm, she finds herself unable to contribute to the discussion due to her lack of experience. This situation echoes Nene’s struggles in the previous episode – all that separates them is a position of authority.
Fascinating take on the development process
This episode does have a fascinating take on the development process of games, however. Both Umiko and Nene are trying to create a fire effect in their respective games but go about it in very different ways. Nene can implement the effect, but she hasn’t optimized it and as a result her game lags and stutters. Conversely, Umiko can create a great looking effect that works, but which still falls short of what is expected from her.
As always, New Game!! tries to be as close to real life as possible. Nene is seen studying a book which teaches C++, and there’s even a giant Photoshop Creative Cloud tome in the animator’s office. These small touches show the audience that the show’s creators have done their research, and lend it an air of credibility.
On the character development front, Eagle Jump’s resident agoraphobe, Hifumi recognizes her social skills is a weakness and decides to take action. She invites Aoba out for coffee and tells her that she’s too inexperienced to be giving anyone orders. Bearing in mind that Hifumi was barely capable of saying hello last season, this is a huge improvement for her. She’s a very talented 3D modeler, and her input is critical to the success of the game, so it would be nice to see her open up some more as the season progresses.
Next week: Better pacing?
This episode has a lot of promise, but its pacing is too slow, especially considering that this is a busy time for a games development team. The show will likely gain traction as the game begins full development, but until then the cast is stuck doing paperwork. Next week’s episode should pick up the pace as the team finishes up the character designs.


Ganduje dethrones, banishes Sanusi, appoints Ado Bayero’s son new Emir
The Kano State Governor, Dr Abdullahi Ganduje, on Monday, dethroned the 14th Emir of Kano, Muhammadu Sanusi II, after the traditional ruler’s five years on the throne.
The Secretary to the State Government, Alhaji Usman Alhaji, in a statement in Kano on Monday, stated that the removal of Sanusi, whose grandfather, Muhammadu Sanusi I, was deposed in 1963, was unanimously approved by the state executive council.
Before the state government announced Sanusi’s dethronement at 11am on Monday, there were signs that a major decision was in the offing as heavily armed security agents were drafted to the major parts of the city, including the palace of the monarch.
About six hours after Sanusi was deposed, the state government announced Alhaji Aminu Ado Bayero, a son of the 13th Emir of Kano, Alhaji Ado Bayero, who died in 2014, as the successor to the dethroned monarch.
The state government as early as 8am had invited journalists to the Government House for what a top officer said was “an important state matter.”
Reading the statement, which conveyed the dethronement of Sanusi, the secretary to the state government stated that the emir was dethroned for “total disrespect to lawful instructions from the office of the state governor and other lawful authorities, including his persistent refusal to attend official meetings and programmes organized by the government without any lawful justification which amount to total insubordination.”
He further alleged that Sanusi breached part 3 section 13 (a-e) of the Kano State Emirate Law 2019, adding that if left unchecked the deposed monarch would “destroy the good and established image of the Kano Emirate.
“This removal is made after due consultation with the relevant stakeholders and in compliance with part 3 section 13 of the Kano State Emirate Law 2019 and other reasons stated above.
“This removal was reached in order to safeguard the sanctity, culture, tradition, religion and prestige of the Kano Emirate built over thousand years.”


text:
dog lover & media student
Hey! My name is Emilie and I'm a media student from Germany. I also speak French and English. I love dogs, but unfortunately, I'm allergic to cats. I have a cute little labrador called Nemo, and I grew up with guinea pigs.
Why I want to house sit
I am nearly done with my studies so I figured: this will be the best time in my life to travel on my own. Housekeeping is perfect for me, because I can give something back and see places you can't always experience as a tourist. And the…
Unfortunately, I didn't sit a house before - except the one of my parents... but I have travel and pet experience and live on my own, so I guess that's a good start to housesitting!
Pet care experience
- Small pets
- Available on these dates — get in touch to find out if they can sit for you

domain: hobby


text:
I am 37 years old, 6'1" about 183 lbs, non-smoker, social drinker. My BP runs between 115/75 and 135/90. I was dx about 10 years ago with seasonal asthma and until recently rarely needed an inhaler. I must note that I think I am an anxious person. I think my pulse is fast a time but resting pulse is below 80. No one in my immediate family has died before the age of 60. High BP and mitral valve run in the family.
Start about 12 weeks ago, I started having all of the following symptoms at different times. Lightheadedness/dizziness, chest pressure/light pain behind sternum that sometimes radiates around my ribs (the pressure/pain feels close to the skin), pressure between shoulder blades, SOA/labored breathing, the sensation that something is in my lungs and throat that I need to cough up, palpitations, I feel winded when going up steps or bending over, neck seems tight, and feels like heart is beating hard. I typically do not have any symptoms at night and I usually feel good in the morning. Symptoms usually start occurring within 30 minutes of getting out of bed. I have trouble sleeping from time to time. These symptoms started about the time I found out my mother-in-law that cares for my kids had to have triple bypass.
Testing & Treatment
I have seen my PCP several times. First he said asthma and prescribed the Advair inhaler, which I'm not sure if it helps or not. I went back because issues persisted and he said that I don't have any risk factors and that it's most likely anxiety but I got a chest xray that was read as normal. About 1 month later I went in for my work paid health screening that included CBC, CM7 and TSH. All blood test were normal. Two weeks ago I called for an appointment because things were no better. He ordered a echo and holter and I have an appointment to see his this week. I know the echo is normal.
Is this or could it be related to anxiety, silent reflux, or something more serious? I've always been concern about something happening (cancer, heart attack) that could have been prevented. I feel like I'm going crazy.
I have started taking a multivitamin and adding Magnesium . I just ordered a lavender based pill called CalmAid and relaxing teas. I really don't want to go on anxiety medication.