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Many thanks to HarperCollins for sending me this ARC!
Eva Tilling wakes up in the hospital to discover an attempt has been made on her life. But who in her sleepy town could have hit her with their car? And why? Before she can consider the question, she finds that she's awoken with a strange new skill: the ability to foresee people's deaths when they touch her.
While she is recovering from the hit-and-run, Nate, an old friend, reappears, and the two must traverse their rocky past as they figure out how to use Eva's power to keep her friends- and themselves- alive. But the killer is obsessed and will stop at nothing to get Eva...
I'm a big fan of psychological thrillers and boy I didn't expect Made For You to be this good! I confess I'm new to Melissa Marr's writing, but this murder mystery set in a small town in North Carolina was right up my street! Ever since reading Gone Girl, I really like messed up books- bit weird? Oh well!
This book isn't just a murder mystery with a bunch of weirdos in it, no it does have a romantic side only one relationship is a little bit more screwed up than the other.
We have Eva who is the victim of this story and is knocked down by a car, an accident that was intended to happen that leads to a spiral of bad happenings to her friends. One positive outcome of this book was when Eva is reunited with an old childhood friend Nate who she's had a crush on since forever. They have a realistic connection that isn't instant and even better, it doesn't take over the whole book to bore you to tears! Nate is cute, and incredibly supportive of Eva's recovery and of discovering who her potential killer was.
As the novel progresses, Eva has visions of her friends' death when they touch her. Whether this is from the outcome of her accident, possibly. But even if Eva feels like she's going mad, these visions could save her and her friends life from someone in her own close group of friends. Unknown throughout most of the novel, I originally thought it was Nate- so it just shows that this story isn't so predictable as I thought it was going to be (silly me!).
The killer himself believes that him and Eva are meant to me together and will stop at nothing to get her, he goes far as murdering those he's known all his life. Yeah...
After reading this novel, I'm now sleeping with one eye open...perhaps keeping your friends close may not always be the best idea!
There was plenty of suspense throughout and continually kept me guessing, at times deeply disturbing and completely mind-blowing when reading the perspective of the killer. I'm glad I didn't understand his thoughts at all haha.
This being said, although this novel was a quick read for me that took over my mind, not an awful lot happened. Instead of a couple of months it felt like this book was set over a couple of days. I think my rating would be higher if perhaps it was more twisty and lasting a longer amount of time than a few months- it would give it more suspense perhaps? Normally I love fast paced books, but for whatever reason I wanted this book to be more prolonged. Other than that, I can't fault this book!
Definitely deserving of a three star rating and I'm most certainly going to check out Melissa Marr again!


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Best practices for drought preparedness and mitigation and water management for increased food security in North Africa
This study was conducted within the framework of the recommendations of the seminar on "Water management and irrigation”. The main purposes of the study on best Practices for drought preparedness and water management with ...
Mitigating the impact of HIV/AIDS on smallholder agriculture, food security, and rural livelihoods in southern Africa : challenges and action plan
This document contains the challenges and action plan, for Mitigating the impact of HIV/AIDS on smallholder agriculture, food security, and rural livelihoods in southern Africa.
Principles, methodology and strategy for promoting the African green revolution : a design and training manual
Now and again, it has been argued that lack of appropriate/improved technologies and non-use of complementary improved inputs are the root causes of the African vicious circle of low agricultural productivity, food shortage, ...

domain: agronomy


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After our heroes thwarted the plans of Team Aqua and Team Magma, the two rival gangs moved to Regma Region to carry out their plans! Stop them from ruining your region and save everyone from the destruction they will undoubtedly cause in Pokemon Fluorite!
Pokemon Fluorite is a wonderful ROM hack based on the official Pokemon Emerald version. The game takes place in the new region called Regma where rumors of Team Aqua and Team Magma’s appearances began. In this game, you found out that the two rival teams wish to continue their destructive ways, and this time, they want to do it in the region you live in! Become the hero of the region and start your adventure with one of the two rare Pokemon: Gilgar or Sneasel.
Click inside the screen to activate controls
Arrow keys – Movement
Space – Select
Enter – Start
“Z” key – a button
“X” key – b button
“S” key – r button
“A” key – l button
To save your game:hover over the emulator screen and use the icons to save your progress.
Down arrow icon (save), Up arrow icon (load).
There have been 36 likes from 41 votes on this game.
Play Pokemon Fluorite game online in your browser free of charge on Arcade Spot. Pokemon Fluorite is a high quality game that works in all major modern web browsers. This online game is part of the Adventure, Strategy, GBA, and Pokemon gaming categories. Pokemon Fluorite has 36 likes from 41 user ratings. If you enjoy this game then also play games Pokemon Fire Red Version and Pokemon Emerald Version. Arcade Spot brings you the best games without downloading and a fun gaming experience on your computers, mobile phones, and tablets. New arcade games and the most popular free online games are added every day to the site.

domain: game


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Surfing Games - Новейший ИгрыЛучшие онлайн surfing games, бесплатно играть
Фильтры: Новейший Наивысший рейтинг большинство сыграно
Surfing is a surface water sport in which the wave rider, referred to as a surfer, rides on the forward or deep face of a moving wave, which is usually carrying the surfer towards the shore. Waves suitable for surfing are primarily found in the ocean, but can also be found in lakes or in rivers in the form of a standing wave or tidal bore. However, surfers can also utilize artificial waves such as those from boat wakes and the waves created in artificial wave pools.
So, here you have the chance to do everything you've ever dream of. Side by side with your friends you can start this journey. The waves will carry you where you want to and your day will become brighter. Have a look here on our website VitalityGames.com and check out our selected surfing games. As in any sport, there is a technique that everyone has to use. Three major subdivisions within standing-up surfing are long boarding and short boarding and these two have several major differences, including the board design and length, the riding style, and the kind of wave that is ridden. You can check out more games and be sure to share ours among your friends. This could be a hole different experience of what you have experience so far. Enjoy!
Проверьте эти Surfing Games перечисленные на странице 1. Всего у нас 18 Surfing Games наиболее популярными из которых являются: FlipSurf.io, Subway Run New 2019, Downhill Ski, и многие другие бесплатные игры. На этой странице перечислены игры с 1 по 18. Этот список из Surfing Games получил оценку 4,21 / 5.00 из 568 голосов.

domain: hobby


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Cord blood stem cells continue to be an interesting subject especially in treating neurological disorders. They have shown to be helpful in various medical conditions. Can cord blood help Parkinson’s?
Let’s find out here.
Can Cord Blood Help Parkinson’s?
There’s no conclusive evidence yet that cord blood can help Parkinson’s disease. However, a recent study suggests that it can improve motor dysfunction for people suffering from this condition.
Parkinson’s disease is a neurological condition. It affects the nerve cells in the brain causing them to die.
Some of these nerve cells control the body’s coordination and movement. As a result, sufferers experience tremors, stiffness, slowness, and impaired balance and coordination.
When the nerve cells degenerate, dopamine levels are also reduced. Dopamine is a vital chemical that sends signals to various parts of the brain to control body movements.
Insufficient levels of dopamine can result in uncontrolled body movements. Thus, patients jerk. They also lose their sense of smell. Some suffer from sleep disorders or depression.
Because it affects the brain, it’s difficult to combat. The only thing that the doctors could recommend is to advise patients to take medicines to alleviate the symptoms.
Recently, however, the International Stem Cell Corporation has started a clinical human trial on patients with Parkinson’s disease.
According to this report,
“In pre-clinical studies, preliminary results have shown that dual stem cell treatment dramatically enhances neuro-regeneration. Following proof of concept work, the research team plans to complete clinical manufacturing steps in CCBC’s FDA-approved facility to rapidly transition their approach to a Phase I safety clinical trial in patients who have failed standard medical therapy and are undergoing electrode placement for planned deep brain stimulation.”
Stem cell treatment has also been used to improve the symptoms of Ozzy Osborne, the heavy metal icon. It was revealed that one round of this treatment lessened the musician’s symptoms. He’s now building his muscle strength back.
So, can cord blood treat Parkinson’s?
It’s too early to say. But researchers are making advanced progress. The unique ability of stem cells can help the body to self-renew and divide into specialized cells.
What Diseases are Treatable with Cord Blood?
Some diseases are included on the list of cord blood uses. However, it’s important to note that most of these diseases are inherited genetic diseases.
If a child has a genetic disease and requires a transplant, the child can receive a cord blood unit from an unrelated donor or a sibling.
Many children are using their cord blood. This is an area known as regenerative medicine. But there are still clinical trials to treat conditions such as autism and cerebral palsy.
Cord blood stem cells are being used to rebuild new blood and immune system that has been damaged by disease. In regenerative medicine, cord blood is infused into the patient to stimulate the body’s repair system.
Here are some of the medical conditions that can be treated with cord blood stem cells:
- Malignancies, like leukemia, multiple myeloma, bodkin’s disease, solid tumors, etc
- Blood disorders
- Metabolic disorders
How Much Does Stem Cell Treatment for Parkinson’s Cost?
Restorative stem cell therapy to treat Parkinson’s disease is a growing practice across the world. Doctors have been using adult stem cells from the umbilical cord to treat cancers.
They are not the same as mature nerve cells. The reason for this is that stem cells can replicate. Because of that, they are a powerful weapon against neurological disorders, including Parkinson’s Disease.
The cost of stem cell treatments, however, can be exorbitant to many. It can run between $10,000 and $35,000. The overall cost will depend on the treatment and other travel costs.
Stem cell therapy is a journey of hope for many people struggling with this medical condition. Sufferers hope that this therapy will provide them with immediate benefits.
Can Stem Cells Cure Parkinson’s?
As mentioned earlier, there’s no conclusive evidence. Scientists are still investigating how stem cells could treat or prevent this debilitating condition.
But this therapy has shown promising results in various clinical trials. More studies are needed to minimize the side effects while measuring its efficacy.
Stem cells can provide new neurons to replace neurons that have been lost because of the disease. Scientists will continue to study the effects of stem cell therapy in patients with Parkinson’s disease before it can be used widely.
Thus, before you spend thousands of dollars on this treatment, you should talk to your doctor. This type of treatment is still in the early stage.
How Can You Reverse Parkinson’s Disease?
Stem cell therapy has shown promising results. But there’s no conclusive evidence yet. There are ongoing studies in patients with PD to transplant pre-made cells into the brain.
In some studies, scientists found that astrocytes could be transformed into dopamine-producing cells in the brain. It paves the way to replace the cells that have been lost without the transplant.
Does Stem Cell Cord Blood Therapy Work?
It’s difficult to know if this therapy does work. The studies are still ongoing to know the effectiveness of this therapy for patients with PD. It will probably take more years before scientists could prove that this therapy does work to cure Parkinson’s disease.
For now, this therapy is still being thoroughly studied. It’s also important to note that safety day data is limited.
Some researchers question whether the number of stem cells harvested is enough to be meaningful in the treatment.
It’s also not clear how this therapy would target the affected cells. For instance, if it is introduced in the nose, it’s not clear how they could find their path to the basal ganglia to make a necessary connection and help the patient with PD.
Again, researchers are still working on the effectiveness of cord blood therapy in treating Parkinson’s disease.
Can cord blood help Parkinson’s? There’s no conclusive evidence yet. However, various reports are showing that this treatment could help in treating PD. Thus, before you invest thousands of dollars in stem cell cord blood therapy, it’s important to talk to your doctor. Study this option carefully.
To learn more, find out here if cord blood stem cells can be multiplied.

domain: medical


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THE EY Foundation – EY’s independent charity – has successfully supported a group of students in the Midlands as part of an ongoing relationship with the University of Warwick – providing young people with a unique and valuable learning experience.
The ten Year 12 students took part in the EY Foundation’s Smart Future’s Business Experience programme earlier this year at the Warwick Arts Centre, the University’s multi-venue arts complex, which reopened its doors at the start of October following a £25 million refurbishment project.
They were tasked with working alongside the University’s Organisational Development team and Warwick Arts Centre leadership team to come up with a plan to promote the venue’s paid and unpaid employment opportunities.
This included attracting performance stewards, volunteers, and restaurant team members, from the local community, with a focus on appealing to a diverse range of candidates.
The EY Foundation works with young people, employers, and social entrepreneurs.
It helps young people from low-income backgrounds to realise their career ambitions and transition into work, higher education or self-employment.
Smart Futures is one of the programmes offered by the EY Foundation and is designed to provide young people with real hands-on experience of the working work.
The programme provides paid work experience, training and interactive workshops, and mentoring relationshipss, helping students to develop a wide variety of transferable skills.
Anu Law, Midlands Hub Lead for the EY Foundation said: “We were absolutely delighted to work with the University on this project, to help bring business experiences to life for our Smart Futures students.
“The students gained valuable business insights and really enjoyed the activity. We’ve already seen some positive outcomes with one of the students having been accepted onto the University’s Warwick Scholars programme.”
Kulbir Shergill, director of social inclusion at the University of Warwick, said: “The EY Foundation’s programmes are hugely important in supporting social mobility for young people from disadvantaged backgrounds to achieve their career aspirations.
“We were really pleased to have been able to support the Foundation in its aims, giving these inspirational young people valuable work experience and importantly access to our facilities and staff to undertake this project.”

domain: sociology


text: This will be the most fun you and the lads will ever have! It’s a Knockout is the perfect team building activity to bring some bonding to the group. There will be bouncy castles, wacky oversized costumes, inflatable obstacle courses and loads of foam. This is completely safe, regardless of your fitness levels, It’s a Knockout experience caters for everybody. Bring your inner child out with this hilarious experience, whether it is for climbing a Slippery Slope or running around in a gigantic costume. It will be a day full of laughs, challenges and excitement.

domain: entertainment


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Childhood Obesity Evidence Base: Using NCCOR’s Newest Dataset to Examine Childhood Obesity InterventionsMAR 24
On Wednesday, March 24, 2021, the National Collaborative on Childhood Obesity Research (NCCOR) is hosting a Connect & Explore Webinar called “Childhood Obesity Evidence Base: Using NCCOR’s Newest Dataset to Examine Childhood Obesity Interventions.” The webinar will give an overview of the Childhood Obesity Evidence Base and lead you through the process of conducting a taxonomic meta-analysis with this resource.
Hear from the authors of the resource during the Connect & Explore Webinar:
• Laura Kettel Khan, PhD, MIM, Senior Scientist and Advisor, Obesity Prevention and Control Branch, Division of Nutrition, Physical Activity, and Obesity, Centers for Disease Control and Prevention
• Deborah Young-Hyman, PhD, Health Scientist Administrator, Office of Behavioral and Social Sciences Research, Office of the Director, National Institutes of Health
• Lori Scott-Sheldon, PhD, Division of AIDS Research, National Institutes of Mental Health
• Mackenzie Magnus, MPH, MBA, Mission Measurement
• Heather King, PhD, Mission Measurement


Lionel “Leo” Messi, the 30-year-old Argentine considered to be one of the best football players in the world, married his 29-year-old childhood sweetheart, Antonella Roccuzzo, on Friday in their hometown of Rosario, Argentina.
As Messi is the third-highest-paid athlete in the world, bringing in $80 million (£62 million) in salary and endorsements, the event certainly didn’t disappoint.
The glitzy, star-studded bash took place at the City Center Rosario complex and was attended by a host of football royalty, including Luis Suarez, Cesc Fabregas, Javier Mascherano, and Carles Puyol.
Guests were instructed to bring several outfits for the glamorous affair, according to The Daily Mail, while mobile phones were strictly off-limits. Some 450 police officers were even deployed to the event.
Fortunately for us, some guests managed to take photos and video footage. Scroll down for a peek behind the scenes of the lavish wedding.
Check out the beautiful pictures below
Sources: Business Insider, NaijaLoaded, Daily mail


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The Scottish Government has published its Programme for Scotland 2018-19, setting out its plans for Scotland in the next year, including the Bills that will be introduced to the Scottish Parliament.
The proposed Non-Domestic Rates Bill will deliver the ambition set out in the Barclay Review to enhance and reform the business rates system in Scotland to better support business growth and long-term investment and reflect changing marketplaces. The Bill will introduce measures aimed at improving the administration of the system including to reduce the number of appeals and improve the quality of information available to stakeholders. It will also deliver measures to increase fairness and ensure a level playing field by reforming a number of reliefs and tackling known avoidance measures. CTG members are reminded that the deadline for responses to the consultation on the implementation of the Barclay Review recommendations is 17 September 2018. Please either submit feedback via the comments box or by e-mail to [email protected].
The Scottish Government has continued to call on the UK Government to give the Scottish share of the Tampon Tax Fund to the Scottish Government to allow it to distribute those funds in line with Scottish priorities.
The Scottish Government has also confirmed that it will consult on updating legislation to promote transparency and accountability to ensure public confidence in charities and in the Scottish Charity Regulator is maintained.

domain: economics


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Potential conflict of interest: Nothing to report.
The CD154–CD40 interaction is a critical costimulatory pathway modulating the cellular immune response. Moreover, fulminant hepatitis of various etiologies is characterized by a hepatic influx of CD154-expressing T cells and an upregulation of CD40 expression on Kupffer cells and hepatocytes, implicating this pathway in the pathogenesis of fulminant hepatitis. In this study, we used a murine model of fulminant hepatitis induced by concanavalin A (con A) and documented a significant influx of CD154-expressing T cells into the livers of mice treated with con A, in association with markedly increased expression of CD40 restricted mainly to hepatocytes in damaged areas of the liver. Furthermore, con A hepatitis in CD154-deficient mice was significantly attenuated compared with that in wild-type controls and was associated with a decrease in hepatic tumor necrosis factor α (TNF-α) levels and hepatocyte death. We next determined the role of the CD154–CD40 pathway in hepatocyte death in vitro. These in vitro studies demonstrated that TNF-α induces CD40 expression in hepatocytes and that subsequent activation of CD40 results in hepatocyte apoptosis mediated at least in part by enhanced hepatocyte expression of FasL. In conclusion, CD154 stimulation of CD40 plays a central role in hepatocyte death in fulminant hepatitis through direct and indirect pathways that may have direct therapeutic implications in humans. Supplementary material for this article can be found on the HEPATOLOGY website (http://interscience.wiley.com/jpages/0270-9139/suppmat/index.html). (HEPATOLOGY 2005;42:372–380.)
Fulminant hepatitis (FH) is a devastating liver disease associated with an extremely high mortality rate.1–3 It is unclear why some patients develop FH while others exposed to the same hepatic insult do not. However, it has been suggested that uncontrolled systemic immune activation coupled with aberrant antigen presentation and T-cell activation play crucial roles in driving FH.4 Efficient T-cell activation requires recognition of two signals, including T-cell receptor (TCR) activation upon recognition of major histocompatibility complex (MHC)-peptide complex, and costimulatory signals.5 The CD154–CD40 system is an important costimulatory pathway.6, 7 Cumulative studies have revealed the critical role of this system in immunoinflammatory disorders.8–10 Moreover, a marked upregulation of CD40 has been observed in the livers of patients with FH coupled with an influx of CD154-expressing lymphocytes.11 Therefore, it is very likely that the CD154–CD40 pathway is involved in the pathogenesis of FH.
The study of FH in humans is hampered by the lack of available clinical specimens as well as the difficulty in defining the critical early events in FH.2 Therefore, the study of early events that may drive FH requires the use of animal models. One animal model that closely mimics FH is acute murine hepatitis caused by the intravenous injection of concanavalin A (con A).12–15 Specifically, intravenous administration of con A in mice mimics FH in humans in the following ways: (1) systemic immune activation and recruitment of activated T cells to the liver and stimulation of hepatic antigen-presenting cells (APCs) (i.e., Kupffer cells);12, 16, 17 (2) acute dose-dependent liver injury, which ranges in spectrum from mild hepatitis to liver failure;2, 3 (3) hepatocyte death mainly due to apoptosis and driven by both FasL/Fas and tumor necrosis factor α (TNF-α) pathways;18–20 (4) a pivotal role of the cytokines TNF-α and interferon γ (IFN-γ) in the development of hepatitis;14, 21, 22 and (5) upregulation of hepatic C-C chemokine expression.23, 24
Therefore, given the central role played by CD154–CD40 interactions in regulating the cellular immune response and the observation of an upregulation of CD40 expression and infiltration of CD154-expressing lymphocytes in the livers of patients with FH, we investigated the potential role of CD154 in the development of con A–induced hepatitis.
Male (aged 10-12 weeks) wild-type (WT) and CD154 knockout (KO) mice (all on C57BL/6 background) were purchased from the Jackson Laboratory (Bar Harbor, ME). Mice were group-housed under controlled temperature (22°C) and photoperiod (12:12-hour light/dark cycle) and allowed unrestricted access to standard mouse chow and tap water. Protocols were approved by the University of Calgary Animal Care Committee, and all procedures were conducted in accordance with the regulations of the Canadian Council on Animal Care.
Anti-mouse FcγR III/II monoclonal antibody (mAb) (2.4G2), fluorochrome-conjugated anti-mouse NK1.1 mAb (PK136), anti-mouse CD3e mAb (145-2C11), anti-mouse CD4 mAb, anti-mouse CD40 (3/23), anti-mouse CD154 mAb (MR1), anti-mouse CD69 mAb (H1.2F3), anti-mouse FasL mAb (MFL3), and anti-mouse Fas mAb (Jo2) as well as isotype-matched control antibodies were obtained from BD Pharmingen (San Diego, CA). Rat anti-mouse CD40 mAb (3/23) and biotinylated goat anti-rat immunoglobulin G were also obtained from BD Pharmingen. Rabbit anti-mouse Fas antibody and biotinylated anti-rabbit immunoglobulin G were obtained from Calbiochem (San Diego, CA), and rabbit anti-mouse FasL antibody was obtained from Santa Cruz Biotechnology (Santa Cruz, CA).
Generation of Con A–Induced Hepatitis.
Con A (Sigma, St. Louis, MO) or phosphate-buffered saline (PBS) was injected intravenously at a dose of 13.5 mg/kg (this dose was chosen to give severe hepatitis without mouse mortality).23 Mice were sacrificed 2 and 8 hours following con A administration. Extent of hepatitis was determined biochemically (ALT kit, Sigma) and histologically (hematoxylin-eosin staining).
Cytokine Determination via ELISA.
Hepatic TNF-α, interleukin (IL)-4, IFN-γ, and IL-12 levels were determined via ELISA as previously described23, 25 and results expressed pg/mg protein (Bio-Rad, Mississaugua, ON, Canada).
Isolation of Hepatic Lymphocytes, Macrophages, and Natural Killer T Cells.
The isolation of hepatic mononuclear cells was performed as previously described.23 The number of CD4+ T and natural killer T (NKT) cells were determined via staining with flurorescence-conjugated anti-CD4 mAb and anti-NK1.1 mAb followed by fluorescence-activated cell sorting (FACS). Isolated hepatic mononuclear cells were also used for staining of CD154 expression. Hepatic neutrophil infiltration was determined via esterase staining of liver sections and the number of neutrophils counted as previously described.26
Enrichment of Splenic CD4+ T Cells.
Spleen cells were isolated using routine methods.27 Splenic CD4+ T cells were enriched via magnetic cell sorting (autoMACS; Miltenyi Biotec, Auburn, CA) using a commercial mouse CD4+ T-cell–negative selection kit (Miltenyi Biotec). Purified CD4+ T cells or splenocytes were cultured in the presence of con A (10 μg/mL [Sigma]) at different time points as described for determination of CD154 and CD69 expression via FACS.
Immunohistochemical Analysis of Hepatic CD40 Expression.
Hepatic CD40 expression was determined via an indirect immunoperoxidase technique on cryostat liver sections as previously described28, 29 using primary antibody (rat anti-mouse CD40 mAb, clone 3/23 [BD Pharmingen]), biotin-conjugated goat anti-rat immunoglobulin polyclonal antibody (BD Pharmingen) and strepavidin-horseradish peroxidase (BD Pharmingen). Expression of Fas or FasL in liver tissues was also determined with the same method using paraffin-embedded liver sections.
Preparation of Mouse Hepatocytes.
Mouse hepatocytes were prepared via a two-step in situ perfusion method using a commercial kit from Invitrogen/Gibco (Burlington, ON, Canada) as previously described.30 The number and viability of isolated cells were determined via trypan blue exclusion.
Determination of the Effect of TNF-α on CD40 Expression on Hepatocytes.
Following isolation, hepatocytes were seeded in collagen I–coated six-well plates and cultured in WE medium (Invitrogen/Gibco) containing 10% fetal bovine serum for 3 hours before replenishing medium, followed by 24 hours culture for recovery before treatment with 10 ng/mL recombinant murine TNF-α (rmTNF-α) (R&D Systems, Minneapolis, MN). After 12 hours, cells were collected and stained with phycoerythrin-conjugated anti-CD40 mAb followed by FACS analysis as detailed below.
Evaluation of Functional Consequences of CD40 Activation on Hepatocytes In Vitro.
After isolation, hepatocytes were seeded in 6-well plates and 8-well chamberslides. Cultured cells were pretreated with rmTNF-α (10 ng/mL) in the presence or absence of 50 ng/mL anti-FasL antibody31 for 12 hours followed by stimulation with 1 μg/mL anti-CD40 antibody (BD Pharmingen) for a further 4 hours. Control groups included cells with no stimulation, cells treated with TNF-α (10 ng/mL × 16 hr) alone, or cells treated with agonistic anti-CD40 antibody (1 μg/mL × 4 hr) alone. The expression of Fas/FasL on hepatocytes was determined via FACS. Hepatocyte apoptosis was determined via immunofluorescent staining with FITC-conjugated Annexin V based on the supplied protocol (BD Pharmingen).
Evaluation of Functional Consequences of CD40 Activation in Con A–Treated CD154 KO Mice In Vivo.
To determine if the attenuating effect of CD154 deficiency on con A hepatitis could be reversed by activating CD40, we administered agonistic anti-CD40 antibody (200 μg/mouse or isotype control mAb [BD Pharmingen]) to con A–treated CD154 KO mice and measured serum alanine aminotransferase (ALT) levels 8 hours later.
Flow Cytometry Analysis.
To analyze the expression of CD154 and CD69 on CD4+ T cells, and CD40 or Fas/FasL on hepatocytes, FACS analysis was performed as previously described.23, 32, 33
All data are expressed as the mean ± SEM. Comparisons between two experimental groups of data were performed using an unpaired Student t test. Comparison among three or more experimental groups of data was performed using one-way ANOVA. Post hoc comparisons were performed using Bonfferonni multiple comparison tests. A P value of less than .05 was considered significant.
CD154 and Con A–Induced Liver Damage.
Con A–treated WT mice displayed severe hepatic necrosis and significant infiltration of inflammatory cells 8 hours after con A injection. In contrast, CD154 KO mice exhibited significantly reduced liver damage (Supplementary Fig. 1). Consistent with histological findings, serum ALT levels were significantly lower in CD154 KO mice 8 hours after con A treatment compared with WT mice. Serum ALT levels were not significantly elevated in WT or KO mice 2 hours after con A administration (Fig. 1).
CD154 and Intrahepatic Cytokine Levels in Con A Hepatitis.
Con A–induced liver damage is mainly driven by the infiltration of CD4+ T cells and activation of hepatic NKT cells and macrophages, as well as the specific cytokines produced by these cells—mainly TNF-α, IL-4, IFN-γ, and IL-12.12, 13, 34 Therefore, we determined the hepatic levels of these four cytokines in con A–treated mice. Con A treatment resulted in significant increases in hepatic levels of all four cytokines in WT mice 8 hours after con A injection. However, hepatic levels of TNF-α and IL-4 were significantly lower in con A–treated CD154 KO mice compared with WT mice at this time point (P < .05) (Supplementary Fig. 2). In contrast, hepatic IFN-γ and IL-12 levels were similar in WT and KO mice 8 hours after con A administration (IFN-γ: WT-PBS 4.1 ± 1.2 and KO-PBS 3.8 ± 1.0 pg/mg protein vs. WT-con A 8.6 ± 1.8 and KO-con A 10.5 ± 3.4 pg/mg protein [P < .05 vs. respective controls]; IL-12: WT-PBS 3.1 ± 0.7 and KO-PBS 3.2 ± 0.7 pg/mg protein vs. WT-con A 9.5 ± 2.5 vs. KO-con A 8.5 ± 3.8 pg/mg protein [P < .05 vs. respective controls]) (n = 6 mice per group). Furthermore, lower hepatic TNF-α and IL-4 levels were also observed in con A–treated CD154 KO mice compared with con A–treated WT controls 2 hours after con A treatment (Supplementary Fig. 2).
CD154 Expression on CD4+ T Cells Is Upregulated by Con A.
There was no expression of CD154 on hepatic CD4+ T cells isolated from naive mice (Fig. 2). However, CD154 expression on isolated hepatic CD4+ T cells was significantly increased 2 and 4 hours after con A administration but had returned to baseline 8 hours afterward (Fig. 2A). Consistent with our in vivo observations, con A stimulation of isolated splenic CD4+ T cells in vitro resulted in a nearly four-fold increase of CD154 expression compared with unstimulated controls (Fig. 2B). To determine whether CD154 expression was restricted only to hepatic CD4+ T cells after con A treatment, we isolated hepatic NKT cells and macrophages from naive and con A–treated WT mice. We found that con A induced a significant increase in CD154 expression on both hepatic CD4+ NKT cells and macrophages (Fig. 2C-D). In addition, there was a modest but significant decrease in CD69 expression on CD4+ T cells isolated from CD154 KO mice compared with WT mice after con A treatment (Supplementary Fig. 3).
Effects of CD154 Deficiency on Hepatic Cellular Infiltrate After Con A Treatment.
Con A–mediated hepatitis is driven by CD4+ T cells, neutrophils, and NKT cells within the liver, whereas hepatic NK and CD8+ T-cell numbers do not change after con A administration,35 and these two types of cells do not appear to be pathogenic in this model.13, 33 Therefore, we determined the effect of CD154 deficiency on the hepatic cellular infiltrate in con A hepatitis. CD154 KO mice demonstrated similar numbers of hepatic neutrophils and NKT cells after con A administration (Supplementary Fig. 4A-B); however, a small but significant reduction in hepatic CD4+ T-cell infiltration was noted (Supplementary Fig. 4C).
In Situ Hepatic CD40 Expression by Immunohistochemistry in Con A–Treated Mice.
CD40 expression was not observed in naive mice. By 2 hours after con A treatment, CD40-expressing hepatocytes were observed in WT but not CD154 KO mice (Fig. 3A,B). However, by 8 hours after con A treatment, strong CD40 expression was documented on hepatocytes in WT mice (restricted mainly to damaged areas of liver), but only weak CD40 expression was noted in CD154 KO mice (Fig. 3C-D).
CD40 Expression on Isolated Primary Hepatocytes Is Upregulated by TNF-α.
To link the enhanced expression of CD40 on hepatocytes with the increased intrahepatic levels of TNF-α in con A–treated WT mice, we next determined the effect of rmTNF-α on modulating CD40 expression on hepatocytes in vitro. As shown in Fig. 4, rmTNF-α treatment resulted in a two-fold increase of CD40 expression on hepatocytes compared with unstimulated controls. In contrast, recombinant murine IL-1β did not alter hepatocyte CD40 expression (data not shown).
Functional Consequences of CD40 Activation on Hepatocytes.
To determine the potential effects of CD40 activation on hepatocytes, further in vitro experiments were conducted. CD40 activation with an agonistic CD40 antibody in TNF-α–treated hepatocytes in vitro significantly increased hepatocyte Fas/FasL expression (Fig. 5). In addition, CD40 activation also increased the number of apoptotic hepatocytes, as determined by Annexin V staining. Moreover, hepatocyte apoptosis induced by CD40 activation was significantly reduced by pretreatment of cells with a neutralizing anti-FasL antibody (Fig. 6). No significant increase in the number of apoptotic cells was observed in hepatocytes treated with TNF-α or anti-CD40 antibody alone. We confirmed these in vitro results, demonstrating an important effect of CD40 activation on hepatocytes upon subsequent hepatocyte death in vivo. Specifically, con A–treated CD154 KO mice demonstrated significantly lower serum ALT levels 8 hours after con A treatment compared with con A–treated WT mice (Fig. 7). Treatment of CD154 KO mice with an agonistic CD40 mAb before con A treatment completely abrogated the effects of CD154 deficiency with regard to con A hepatitis (Fig. 7).
To determine whether there are similar changes in hepatocyte Fas/FasL expression in con A–treated mice in vivo, we determined the expression of Fas/FasL by immunohistochemistry. Hepatic expression of Fas/FasL in con A–treated WT mice were strikingly increased compared with CD154 knockout mice. As shown in Fig. 8, strongly positive staining hepatocytes for Fas/FasL were observed in damaged areas of liver in WT mice 8 hours after con A treatment, whereas there were only a few positively stained cells in the livers of con A–treated CD154 KO mice.
In this study, our results demonstrate that the CD154–CD40 pathway plays a major role in the development of con A–induced hepatitis. Specifically, CD154 deficiency significantly attenuates con A hepatitis—an effect completely abrogated by the exogenous administration of an agonistic CD40 antibody.
It is well established that con A–induced hepatitis is driven mainly by the infiltration of CD4+ T cells into the liver that follows hepatic neutrophil infiltration,26 as well as the activation of hepatic NKT cells and macrophages.12–14, 36 Moreover, specific cytokines produced by these cells (i.e., IFN-γ by CD4+ T cells, IL-4 by NKT cells, and IL-12 and TNF-α by macrophages) are critical in the development of con A hepatitis.12–14 We presumed that the lack of CD154 activation of CD40 expressed on hepatic macrophages would result in a reduction of con A–mediated hepatitis by decreasing macrophage production of TNF-α and IL-12. Our results clearly show that con A–induced liver damage in CD154 KO mice is significantly reduced and is accompanied by lower hepatic levels of TNF-α, but not IL-12. Given that the ligation of CD154 with CD40 on macrophages is important for the production of TNF-α,37 and that there is documented clustering of Kupffer cells and T cells in the liver during con A hepatitis,12 and that CD154-expressing T cells infiltrate the liver in con A hepatitis, our results are consistent with a major role of CD154–CD40 interaction–driven Kupffer cell–related TNF-α secretion in con A hepatitis. However, our findings suggest that hepatic IL-12 production during con A hepatitis appears to be CD154–CD40-independent. The observation of similar hepatic IL-12 levels in con A–treated CD154 KO and WT mice is consistent with our observation of similar hepatic IFN-γ levels in these mice.38 Moreover, these findings are consistent with a major role of TNF-α release within the liver, driven by CD154–CD40 interactions, during con A hepatitis. Interestingly, we also documented that hepatic NKT cells and macrophages themselves express CD154 in con A hepatitis, implicating these cell types in the activation of CD40 on antigen-presenting cells such as macrophages in this model, with resultant TNF-α secretion. Macrophage expression of CD154 has previously been identified as an important driver in liver cell death in the setting of liver transplant rejection in humans.31 Hepatic NKT cells are the main source of IL-4 in con A hepatitis,33, 39 and we observed lower hepatic IL-4 levels (proinflammatory in the liver33, 36) in con A–treated CD154 KO versus WT mice, suggesting decreased hepatic NKT cell production of IL-4 in con A hepatitis in the KO mice. Given that we could not document CD40 expression on hepatic NKT cells (data not shown), this finding is of interest and warrants further investigation. Our preliminary studies in this regard have indicated that TNF-α can directly stimulate NKT cell IL-4 production (data not shown).
CD154 is also known to play an important role in cellular recruitment (mainly CD4+ T cells) to inflammatory tissues.40, 41 Therefore, decreased con A–induced hepatitis in CD154 KO mice might also be due to decreased hepatic cellular influx of cell types important in the development of con A hepatitis. CD4+ T cells, neutrophils, and NKT cells are important in this regard.12, 13, 26, 36 CD8+ T cells and NK cells do not appear to play a pathogenic role in this model.13, 33, 35 We documented similar hepatic neutrophil and NKT cell numbers after con A treatment in CD154 KO and WT mice (Supplementary Fig. 4). However, CD154 deficiency was associated with a modest but significant reduction in hepatic CD4+ T-cell recruitment after con A (Supplementary Fig. 4C). This finding suggests that CD154–CD40 interactions may play a role in CD4+ T-cell recruitment in con A hepatitis and that decreased CD4+ T-cell recruitment may contribute, at least in part, to the reduced severity of con A hepatitis in CD154 KO mice. In addition, CD4+ T cells isolated from CD154 KO mice demonstrate a modest defect with regard to con A–induced activation (as reflected by CD69 expression). Although this defect in activation might contribute to decreased hepatitis in con A–treated CD154 KO mice, we feel that this is unlikely given that CD40 stimulation by an agonistic antibody in CD154 KO mice in vivo completely abrogates the effect of CD154 deficiency in con A hepatitis (Fig. 7).
It is well documented that TNF-α plays an essential role in the development of con A–induced hepatitis.13, 14, 42 However, how TNF-α kills hepatocytes remains largely unknown. Our current results demonstrate that rmTNF-α significantly upregulates the expression of CD40 on isolated hepatocytes. Interestingly, the induction of CD40 expression by TNF-α has also been found in other cell types.43–45 Moreover, Afford and colleagues31 reported that enhanced expression of CD40 was observed in human hepatocytes in chronic rejection after liver transplantation, and activation of CD40 was able to induce hepatocyte apoptosis via the Fas pathway. In addition, enhanced CD40 expression has been detected on hepatocytes from patients with fulminant hepatitis,11 and there is increasing evidence indicating the importance of hepatocyte apoptosis induced by the Fas/FasL pathway in the development of con A–induced hepatitis, as well as in fulminant hepatitis.14, 15, 34, 46 Our current data show that CD40 expression is markedly increased on hepatocytes 8 hours after con A treatment, but is present as early as 2 hours after con A administration. In addition, CD40 activation on hepatocytes in vitro results in apoptosis of hepatocytes accompanied by a marked increase of FasL/ Fas expression on hepatocytes. Moreover, blocking Fas/FasL interactions during CD40 activation of hepatocytes partially abrogated apoptosis of these cells. This finding suggests that there may be another non–FasL-driven pathway involved in the CD40-mediated apoptosis of hepatocytes. One such pathway could involve signaling through TRAIL or TNFR1.47, 48 Taken together, our results suggest that TNF-α plays a fundamental role in con A hepatitis by inducing the upregulation of CD40 expression on hepatocytes whose activation induces apoptosis of hepatocytes mediated at least partially by the Fas/FasL pathway. Therefore, based on our findings, we propose a model for the role of the CD154–CD40 costimulatory system in con A–induced hepatitis (Supplementary Fig. 5). We do, however, recognize that this model is an oversimplification of a complex series of events in con A hepatitis.
In conclusion, our studies indicate that the CD154–CD40 costimulatory pathway plays an important proinflammatory role in con A–induced hepatitis by inducing the production of TNF-α within the liver. Subsequently, TNF-α upregulates CD40 expression on hepatocytes, and activation of CD40 induces the apoptosis of hepatocytes through the Fas/FasL pathway. Therefore, we suggest that the CD154–CD40 pathway may be involved in the pathogenesis of FH and that this costimulatory pathway may be a potential target for the development of novel therapeutic approaches to treat patients with fulminant hepatitis.


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The annual Los Angeles Fashion Week is a much-awaited event that not only showcases breathtaking designer clothes and accessories but is also a star-studded affair attended only by the most fashionable and stylish individuals such as Alexandra Creteau.
In the recently concluded event, the famous social media icon was spotted walking down the red carpet and taking part in the opening night’s festivities. The talented woman was photographed alongside other personalities in the entertainment industry, such as artist Rachele Royale, actor Maximilian Acevedo, and Talent Agency Executive Director Pierre Patrick. Her husband and fellow actor David Murrietta Jr. also joined her on the red carpet.
Furthermore, she was personally invited by several prominent fashion brands to attend their shows. On October 8, the fashionable individual watched the MC2 ft Ronaldo Arnoldo and Frisk Me Good shows. The following day, she was seen at the Naids Fashion show.
However, the Los Angeles leg of the global phenomenon is not Alexandra Creteau’s first fashion week experience. In September, she also graced the New York Fashion Week with David. She was present at the Dur Doux Show and has rubbed elbows with beauty queens Miss Universe 2020 Alma Andrea Meza Carmona and Miss USA Asya Branch.
On top of that, she was invited to “The Talks: The Future of Fashion and Luxury,” which talked about the return of French-American luxury designer for ready-to-wear garments, Joseph Altuzarra.
The influencer made sure to chronicle her wonderful experiences by capturing gorgeous photographs and sharing them with her 300,000 plus followers on Instagram. In addition, there is a special section on her story highlights dedicated to her LAFW journey.
She has also uploaded the first part of her New York travel vlog on the YouTube channel she shares with her husband. The social media personality will continue posting more photos and videos relating to her fashion week adventures in the following days and weeks.
Aside from being an influencer and attending fashion events, the multi-talented woman spends her time acting. Recently, she appeared on the red carpet of The Silicon Beach Film Festival to promote her film Vicious Cycle, a short horror film directed by Robby McBride.
She has also appeared in several works, including the short films The Hope, The Hunt, Ambushed, and Tag Team. Additionally, she has worked in popular movies like The Heat, Ted, and Ted 2.
In the future, Alexandra Creteau sees herself becoming a household name and star in mainstream films and television series. Alongside her goal of scaling her success and reaching a wider audience, the gifted actress and fashionista plans to continue attending future fashion week events, both in the United States and in international venues such as Paris and Milan. In addition, she hopes to receive invitations from couture designers and luxury fashion houses on their show. Find out more about Alexandra Creteau’s Los Angeles Fashion Week experience and her other projects by visiting her Instagram account. You can also subscribe to her YouTube channel Dalex Vlogs.

domain: artistic


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Before Your Operation
Quit Smoking Before
Your Operation is part of the Informed Surgical Prep series of patient education
materials. This preoperative smoking cessation handout informs and prepares
patients for surgery. Content includes a general overview of quitting, how to
prepare for one’s quit day, tips for dealing with withdrawal, and a list of top
non-profit and government resources. The handout includes a space to
individualize a smoking cessation plan as well as space to record a list of
identified smoking triggers.
All American College
of Surgeons and Joint Commission guidelines are addressed in the content.
Available in packets of 25.
Developed by the American
College of Surgeons Division of Education, 2012.
members: $15 for each package of 25
Nonmembers: $25 for each
package of 25
Call for bulk pricing.
View this document online:

domain: library


Since its establishment in 2011, A&G ZHEGNZHOU has gone through four sessions and this year is the fifth. It has now developed into the largest exhibition in the field of abrasive grinding in China. This year, A&G ZHENGZHOU will be held in Zhengzhou International Convention and Exhibition Center on August 13-15. It is expected to exhibit an exhibition area of 30,000 square meters, which will attract more than 500 exhibitors and nearly 33,000 professional visitors.
A&G ZHENGZHOU exhibits products covering grinding equipment and tools, abrasives and raw materials, abrasive grinding equipment manufacturing and testing equipment, and related industries. This year, A&G ZHENGZHOU added various types of grinding machines, tools, tools and measuring tools, including surface grinders, tool grinders, guide grinders, internal and external, on the basis of consolidating superabrasives, ordinary abrasives and coated abrasives. Round grinding machines, centerless grinding machines, threaded gear grinding machines, grinding centers, electrical processing equipment, grinding machines, honing machines, polishing machines, lapping machines, grinding robots and other equipment.


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Ladies and gentleman, boys and girls, it’s that time for your evening tech news round up. In today’s US Update we get to the bottom of the Xbox 360 portable rumors, preview Nokia’s MeeGo announcement, track down the Milestone 3, update the Samsung Apple lawsuit and wrap up with a look at the secrets behind the Nokia N8 optics.
Despite what you’ve heard, Microsoft has no plans of releasing a portable Xbox 360 console. The company has gone on record to state the future of Xbox gaming on-the-go begins and ends with Windows Phone. At Nokia Connection 2011 an unnamed MeeGo device is expected to headline the show. The odds on favorite is the Nokia N9.
Clove has no plans to stock the Motorola Milestone 3. Rumors are now circulating suggesting the third generation Milestone, known as the Droid 3 in the states, will remain a stateside-only affair. Apple has responded to Samsung’s request to see the iPhone 5 and iPad 3. The request was denied on the basis that Apple’s claims against Samsung only pertain to current products, not upcoming releases.
Last in this morning is a great video explaining the secrets behind the Nokia N8 12-megapixel sensor. The video is coincidentally recorded entirely using the N8 and that alone speaks volumes. Regardless of how you feel about Symbian, these sensors are impressive. That wraps up the latest and greatest in the wild world of tech news. As always I’m Nick Marshall and I’ll see you again tomorrow.

domain: news


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Posted On: 03/31/19 8:34 PM
Wheat State Elite – Chaos’ summer roster is an experienced group. Many just wrapped up their high school basketball season with appearances in the state tournament. Here’s a look at some of team members.
Emily Ryan, 2020, 5’9″, PG — The Central Plains point guard is currently listed as a 4-star ESPNU HoopGurlzSuper 60 player, ranked #16 in the country. The Gatorade Kansas player of the year in 2018 Ryan is regarded as the most complete player in the state. She has been first team all-class for the past two years and has been on the team’s three recent state championship teams, extending the streak the school has of 111 straight wins and six consecutive championships.
Kade Hackerott, 2020, 5’11”,


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SHOW BLITZ: Tabby is using up his lives.
WONDERING why X-Factor star Tabby Callaghan has been so quiet lately?
The singer has been touring the UK with his band The Tsars and according to one insider the Sligo rocker has been working so hard friends and family fear exhaustion could be looming.
One close pal said: "Tabby is such a hard worker, he's lives and breathes his job. He has been travelling all over the place lately and it's becoming a real strain.
"The good thing is he's looking forward to the release of the new single Take A Swing this month and once promotion for that is over he can have a few weeks break in the summer."

domain: celebrity


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Lobuche Peak, located in the Khumbu region of Nepal, is a popular destination for mountaineers seeking a thrilling climbing experience amidst the awe-inspiring Himalayan landscape. Standing at 6,119 meters (20,075 feet), it offers stunning panoramic views of Everest, Lhotse, Nuptse, and other neighboring peaks. This comprehensive guide will provide you with all the essential information and steps required to plan and execute a successful Lobuche Peak climbing expedition.
Part 1: Preparing for the Climb
- Physical Fitness: Climbing Lobuche Peak requires a good level of physical fitness and stamina. Engage in regular cardiovascular exercises, strength training, and hiking to prepare your body for the demands of high-altitude trekking.
- Acclimatization: Acclimatization is crucial to avoid altitude sickness. Plan your itinerary with gradual ascents and rest days to allow your body to adapt to increasing altitudes.
- Climbing Skills: Acquire basic mountaineering skills such as rope handling, ice axe use, and crampon techniques. Prior experience in high-altitude trekking or climbing is recommended.
- Choosing the Right Season: The best time for Lobuche Peak climbing is during the pre-monsoon (spring) season (April-May) and post-monsoon (autumn) season (September-November) when the weather is stable, and skies are clear.
Part 2: Permits and Logistics
- Permits: Obtain the necessary permits for climbing Lobuche Peak. This includes permits from the Nepal Mountaineering Association (NMA) and Sagarmatha National Park entry permit.
- Trekking Agency: Choose a reputable trekking agency that specializes in Lobuche Peak climbing. The agency will handle logistics, provide experienced guides, and ensure safety throughout the expedition.
- Itinerary: Work with your trekking agency to create a well-structured itinerary with ample acclimatization days and flexibility to accommodate unforeseen circumstances.
- Accommodation: Depending on your preference, you can choose to stay in teahouses along the trail or camp in tents during the ascent. Ensure your chosen accommodations are comfortable and reliable.
Part 3: Climbing Gear and Equipment
- Climbing Gear: Prepare a comprehensive list of climbing gear, including mountaineering boots, crampons, ice axes, harness, helmet, gloves, and warm clothing suitable for extreme conditions.
- Rent or Bring: Decide whether to rent climbing gear from Kathmandu or bring your own equipment. Ensure all gear is in excellent condition and well-fitted before the expedition.
- Personal Items: Pack essential personal items like a sleeping bag, headlamp, sunglasses, sunscreen, first aid kit, and water purification tablets.
Part 4: Safety and Responsible Climbing
- Experienced Guides: Rely on experienced climbing guides with a good track record. They will provide crucial guidance, manage risks, and ensure your safety during the climb.
- Hydration and Nutrition: Stay well-hydrated and maintain proper nutrition throughout the expedition to cope with the physical demands of high-altitude climbing.
- Responsible Climbing: Follow the principles of responsible climbing, including “Leave No Trace” practices, to minimize your impact on the fragile mountain environment.
- Weather Awareness: Be aware of weather forecasts and be prepared to adjust your itinerary if necessary for safety reasons.
Part 5: The Climbing Expedition
- Trek to Base Camp: Embark on the trek from Lukla to Lobuche Peak Base Camp, enjoying the breathtaking scenery of the Khumbu region along the way.
- High Camp: Ascend to High Camp, where you’ll spend a night before the final summit push, ensuring further acclimatization.
- Summit Attempt: Begin the summit attempt early in the morning to take advantage of stable weather conditions. The climb to the summit involves technical sections and requires focus and determination.
- Celebrate and Descend: Celebrate your successful summit and savor the spectacular views. Descend safely to Base Camp and continue back to Lukla, where you’ll catch a flight to Kathmandu.
Climbing Lobuche Peak is a thrilling and challenging adventure, offering an opportunity to witness the grandeur of the Himalayas up close. With careful preparation, the support of a reliable trekking agency, and responsible climbing practices, you can make your Lobuche Peak expedition a memorable and rewarding experience of a lifetime. Remember to prioritize safety, respect the environment, and cherish the unique beauty of the Khumbu region as you embark on this incredible journey.

domain: geography


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When considering what kind of Display Fridge you require for your Shop, you have a choice of multidecks, which are open fronted wall sited units for self service, generally found in Supermarkets or General Stores and fitted with night blinds to save energy when the Store is closed. In certain applications where aisle space is restricted a slimline multi deck would be a good option, offering the same display qualities, but with a smaller footprint.
A serve over counter is ideal for Cafes, Sandwich Bars, Butchers or Fishmongers, and come in Flat Glass options, or a more attractive Curved Glass Canopy, most models have a refrigerated under storage facility with rear doors for easy access and storing reserve products. fresh meat or fresh fish serve overs are usually made to operate at Lower temperatures to preserve the product in better condition at approximately minus 2oc.
Bar and counter chiller displays are usually designed to fit either as a back bar fitting, as found in Pubs & Clubs, with either Sliding or Hinged doors, or other under counter or Counter top models suitable for Sandwich Bars, Restaurants and Cafes, which are available in various styles.
Upright and undercounter glass door chillers or coolers are ideal for all trades, and are available with hinged or sliding doors, in One , Two or even Three door versions some with an illuminated canopy on top for extra logo display.
Wine coolers, are ideal for bars and Restaurants, or even the discerning connoisseur for Home use, and keep both Red & White Wines at the correct storage temperature, some models are suitable for keeping both wines in the same cabinet.
Juice dispensers are available in One, Two or 3 Barrel models whereby a variety of cold Drinks can easily be dispensed, and are fitted with easy to clean header tanks.

domain: design


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Movie fans await popular Ghanaian actress, Yvonne Nelson, as she premieres her latest movie, Single, Married & Complicated, in Nigeria this weekend.
The new movie, which is a sequel to the 2012 hit movie, Single & Married, attracted a lot of buzz across the continent when the actress released posters, snapshots and a trailer for the movie early this year.
Produced by Yvonne’s YN productions and directed by Pascal Amanfo, the movie features a star-studded cast of Chris Attoh, John Dumelo, Alex Ekubo, Eddie Watson, Tana Adelana, Anita Erskine and Berla Mundi, among others.
The cast will be converging at the Silverbird Galleria Cinemas in Lagos where the movie’s main premiere is scheduled to take place. It will also be screened at other Silverbird cinemas across Nigeria.
It is confirmed that the actress will be joined by John Dumelo and some other Ghanaians in the cast at the highly anticipated main premiering event.
The upcoming movie does not only have a lot of interesting and captivating cast; it equally has a very captivating storyline.
Picking up from Single & Married, this sequel continues to explain certain happenings in marriage, with a greater focus on how most men eternally crave to love and to be loved.
It has been described as a suspense-filled story, woven with a comic thrilling plot of love, lust and lies.culled from ghanaweb.com


The counting of votes for the second phase of Gujarat civic polls began on Tuesday, with the ruling BJP emerging ahead of all other parties in the fray. The saffron party is leading in majority of the 81 municipalities. It is also widening the gap with closest rival Congress in district panchayats and taluka panchayats.
Notably, in the second phase, elections were held for 81 municipalities, 31 district panchayats and 231 taluka panchayats.
Till 11.30 am, BJP has secured victory in 358 taluka panchayat seats, whereas Congress won 94 seats. Arvind Kejriwal-led Aam Aadmi Party won four seats. As far as initial trends in the district panchayats are concerned, BJP is leading in 20 out of the 31 seats, whereas Congress is leading in only one seat.
Meanwhile, AAP revealed that 24 party candidates have been officially declared winners from various rural areas and the party is leading in many more seats. AAP tweeted, “Good news coming in from Gujarat! 24 AAP candidates have been officially declared winners from various rural areas. AAP leading in many more seats. The revolution which started in urban Gujarat continues in the rural polls.”
Good news coming in from Gujarat!
24 AAP candidates have been officially declared winners from various rural areas.
AAP leading in many more seats.
The revolution which started in urban Gujarat, continues in the rural polls.#GujaratLocalBodyElection
— AAP (@AamAadmiParty) March 2, 2021
Municipal corporation elections
The BJP has already registered a thumping victory in the six municipal corporation elections held on February 21. BJP has won 483 of the 576 seats in these six municipal corporations that include Ahmedabad, Surat, Rajkot, Vadodara, Bhavnagar and Jamnagar.
Congress’ loss of face
In contrast to the BJP’s stellar performance, the Congress was further decimated in the state, with its tally reducing further as compared to the seats it had won in the previous municipal corporation elections held in 2015. One of the major reasons for the Congress’ poll debacle is the internal fighting in the party as well as selection of candidates.
AAP lost its deposits in most of the seats it contested in all the six municipal corporations.
However, it performed exceptionally well in Surat Municipal Corporation where it went on to win 27 seats decimating the Congress to a big zero. The BJP won the remaining 93 seats in Surat.
This is the first time that AIMIM led by Hyderabad MP Asaduddin Owaisi is contesting the local body polls. Blamed as the ‘B team’ of the BJP, Owaisi’s party went on to win seven of the 21 seats it contested in Muslim-dominated areas in Ahmedabad.
It will be interesting to see how AIMIM performs in the local body polls outside cities. Notably, the party has fielded candidates in minority-dominated areas in Modasa, Godhra and Bharuch municipalities.
To read the latest news in Gujarati click here


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Millions of People Will be Helped, Lives Saved
WASHINGTON, DC (March 21, 2010) — The following statement is being released by Sr. Carol Keehan, DC, president and chief executive office of the Catholic Health Association of the United States (CHA):
The Catholic Health Association applauds the U.S. House of Representatives and President Obama for enacting health care reform legislation that will bring security and health to millions of American families. The reform law will save and improve lives across our country. It represents great progress in the long effort to make health care available and affordable to everyone in the United States.
We call upon the U.S. Senate to move quickly to enact the accompanying correction legislation in order that the full benefits of reform become a reality.
While not perfect, the reform law significantly expands coverage, especially to low-income and vulnerable populations, and is a tremendous step toward protecting human dignity and promoting the common good. The law will prevent insurance companies from denying policies to those with pre-existing conditions; protect families from bankruptcy due to medical expenses; help small businesses provide insurance for their workers; improve Medicare drug benefit coverage by closing the doughnut hole and significantly cut the federal deficit. Most importantly, 32 million people who were previously uninsured will be able to obtain meaningful coverage at an affordable price.
CHA has long championed health care reform that protects life, makes coverage affordable for the greatest possible number of people and puts our system on a path to reducing costs while providing better and safer care. The bill that became law this weekend is an excellent start. We will work with our members and other groups over the coming months to ensure that regulations putting the law into effect are crafted wisely with input from all affected individuals and organizations. During this process, Catholic-sponsored health care providers will continue, as always, to serve everyone who requires our care and compassion — regardless of their ability to pay.
We are confident that the reform law does not allow federal funding of abortion and that it keeps in place important conscience protections for caregivers and institutions alike. We are also pleased that the bill includes $250 million to fund counseling, education, job training and housing for vulnerable women who are pregnant or parenting.
Reaching this point has not been easy, and the days ahead involve hard work to implement the law effectively. CHA and its members stand ready to work with the Administration, Congress and other groups to ensure the long-term success of reform.
The Catholic Health Association of the United States (CHA), founded in 1915, supports the Catholic health ministry's commitment to improve the health status of communities and create quality and compassionate health care that works for everyone. The Catholic health ministry is the nation's largest group of not-for-profit health systems and facilities that, along with their sponsoring organizations, employ more than 750,000 women and men who deliver services combining advanced technology with the Catholic caring tradition.


3D Printing at home: MakerBot Replicator 2 desktop 3D printer.
The 3D printing consumer market has soared in the last two years with companies like MakerBot shaking up the scene by bringing high-quality desktop 3D printing to the home market.
Countless companies and DIYers have followed suit and we have seen a steady number of new machines appearing on the market thanks to crowd funding and a stronger awareness of the technology due to mass media buzz. Just go to Kickstarter now and search '3D print' to see what I mean.
Up until recently, there has been a very specific community of people who have embraced 3D printing and played with the infinite possibilities that can come from a desktop machine. The hacker and maker community has took the technology and brought us these images of things we would have otherwise not thought possible from a modest garage table workspace.
For the mass consumer market, plug in and go systems are available at a competitive price point for hobbyists to get stuck in without the hassle makers in the last 20 years would have endured of building the machine from scratch. Printers can be bought from high street stores, CAD files for free, materials from Amazon; it is so easy to get involved now.
Yet the majority of people are not. This makes me wonder what the industry needs to do or provide, to convince the public that it is worth investing in. Is it better learning tools? Simple apps? Integration? Or is it just time?
This week, Intel revealed they are to include 3D scanning technology into next year’s tablet range and maybe even smartphones. Through Intel RealSense technology, 3D scanning will be made available on portable devices, making the ability to scan and manipulate items without being restricted to a laptop or expensive scanning devices ever more possible.
Intel RealSense scanning technology will be integrated into tablets in 2015
Wacom mirrors the idea that ease of mobility is a key catalyst in getting people interested and developing 3D technology. The 3D design hardware specialists recently told TCT that their products, particularly, The Cintiq Companion are “capable enough to support a mobile, intuitive creative workflow.” By designing tools that fit into a designer’s natural working environment, it makes it easier to integrate that 3D printing manufacturing option because it complements the making process in a disruptive yet positive way.
These days, it seems like everything in life can be consolidated to an app. If you want to stay in touch with your friends, there’s an app. If you want to measure your fitness, there’s an app. If you want to edit photos, there’s an app for that too … and so on. 3D printing is also slowly being packaged into app form. A quick browse through the Appstore and you will find a growing number of applications from third party developers but also from key players in the industry. Like 3D Systems’ Cubify Draw app and the Isense scanner tool which turns your iPad mini into a portable 3D scanner (there it is again, portable).
Even giants like Microsoft have partnered with 3D Systems to improve their own 3D printing app and give it a much simpler interface with design options that can be easily adopted by the casual user and a cloud service that gives more scope for printing options. This tells us that 3D printing is moving in to a much more accessible home market. It is tapping into our daily habits and who knows might be paving the way for a world where we click ‘send’ from a 3D printer App as often as we check our Twitter feeds.
Microsoft 3D Builder App.
A quick question to the public showed that learning tools are something that people still want before taking the plunge with 3D printing. The tools are out there; introductions and courses for 3D printing can be found popping up all over the world but for someone who perhaps just wants to make novelty items at home, that might seem like a fair bit of commitment. 3D printing is still very experimental but times have changed and the out-of-the-box approach has certainly helped to increase the number of people getting into the technology. Yet maybe better tutorials, learning environments, apps, perhaps even honest horror stories of printing gone awry, would better equip people before diving into 3D printing and giving up before they’ve even started.
Of course hardware and material costs will still need to come down before the potential is there for the ideal ‘one in every home’ scenario. But just as iPads were once an expensive, luxury device that people now don’t think twice about splashing out on for their two year olds, if 3D printers can prove themselves to be a useful household tool, perhaps they might just do the same.


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Expect all the fanfare and glamour of 19th-century Vienna with the Strauss Festival Orchestra and Ballet. The concert is a medley of waltzes, polkas and marches by the "King of Waltz", Johann Strauss.
The Strauss Festival Orchestra, celebrated for its virtuoso interpretation of the music of the Strauss family, has been giving highly-acclaimed concerts across Europe for more than 25 years. The musicians are joined here by the Strauss Festival Ballet Ensemble.
Concerts & Live Music


Timeline: How twin Paris hostage situations unfolded
The hunt for one suspect believed to have been involved in the Paris attacks continues
French police officers in an industrial area northeast of Paris where the suspects in the attack at the headquarters of satirical magazine Charlie Hebdo are reportedly holding a hostage. Photograph: Etienne Laurent/EPA
8.20am: Reports that shots have been fired in a car chase northeast of Paris.
8.50am: Reports emerge that two suspects have taken a hostage in the Creation Tendance Decouverte building in an industrial estate in Dammartin-en-Goele, near Charles de Gaulle airport.
9am: Reports emerge that police have entered negotiations with the Kouachi brothers.
9.20am: French authorities confirm that shots were fired at a roadblock but deny reports of injuries.
9.39am: AFP reports that French police have identified a suspect in the policewoman shooting. Residents in Dammartin-en-Goele are being asked to stay indoors and turn off the lights. Nearby schools have been put on lockdown.
9.55am: Charles de Gaulle airport - roughly eight miles away - partially closed as the police operation in Dammartin-en-Goele continues.
11.17am: AFP reports that the suspect in the Paris policewoman killing is now being linked to Charlie Hebdo massacre brothers.
12.10am: The French interior ministry says police are trying to establish contact with the hostage-takers.
12.26pm: Reports emerge that a separate shooting incident has taken place in eastern Paris. It is thought that the gunman in the policewoman shooting has taken hostages in a kosher supermarket.
12.55pm: AFP reports that at least five people have been taken hostage.
1.19pm: Reports emerge that at least two people have been killed in a kosher supermarket in Porte de Vincennes.
It is thought that the gunman, armed with multiple Kalashnikovs, has links with the Kouachi brothers.
The BBC reports that he told forces outside the store, “You know who I am,” and told them to end the siege in Dammartin-en-Goele.
1.32pm: French police release mugshots of a man and woman linked to the policewoman killing.
1.34pm: The Board of Deputies of British Jews advises people to follow the Twitter account of its French counterpart, the Conseil Representatif des Institutions Juives de France (Crif).
A spokesman says they, “Stand with the French Jewish community in steadfast solidarity at this difficult time”.
1.35pm: Police name the grocery store hostage-taker as 32-year-old Amedy Coulibaly, who they believe was also responsible for the shooting of the Paris policewoman.
They also say they are hunting a 26-year-old woman called Hayat Boumeddiene in connection with the killing.
2.06pm: AFP reports that Paris hostage-taker “knows” one Charlie Hebdo killer.
There are reports of a third shooting at the Trocadero near the Eiffel Tower. Police are pictured with their firearms unholstered.
2.27pm: French interior ministry says Trocadero incident is a false alarm.
The BBC quotes Cherif Kouachi’s lawyer telling the terror suspect to surrender.
Vincent Ollivier said: “I would have only one piece of advice to give Mr Kouachi - It would be to hand himself over to police authorities so that all light can be shed on this case.”
Police have called for shops on Rue des Rosiers, in the Jewish quarter of Paris to close early “as a precaution”.
2.30pm: Europe 1 reports that a woman received a phonecall from her mother, who is being held hostage in the shop in Porte de Vincennes.
“She called me and told me, ‘I am in the shop, I love you’.
“I am scared. Someone told me there have been two deaths. No one has told me if it is my mother or not.”
2.47pm: Israel’s minister of foreign affairs Avigdor Lieberman says Israel is concerned over “terror offensive” in France.
3.08pm: Schools near the kosher supermarket where five hostages are being held remain closed. Parents are being advised not to travel into the area to collect them.
3.25pm: Gunman in kosher supermarket has threatened to kill hostages if police storm the building where Charlie Hebdo massacre suspects are holed up, according to officials.
3.39pm: It emerges that the Kouachi brothers, who are known for holding jihadist views, were on a British watch and no-fly list to prevent them from entering the UK or passing through a British airport.
3.55pm: Gunshots and explosions have been heard at the siege in Dammartin-en-Goele. Smoke can be seen above the building where the Kouachi brothers have been holed up for around seven hours.
3.59pm: Flashes of light accompany rapid gunfire which lasts for about 10 seconds.
Minutes before the explosions, balaclava-clad officers are seen moving towards the building where the Charlie Hebdo massacre suspects are reported to be holding one person hostage.
They appear to leave the roof of the building shortly afterwards.
4.01pm: AFP reports that official sources have said police launched an assault on the printworks where the Charlie Hebdo suspects were holed up.
4.08pm: Emergency vehicles, including ambulances, flood the area as smoke obscures the building from view.
4.11pm: Six loud and very quick explosions heard at the kosher supermarket in Paris where a gunman held five people hostage.
4.16pm: Ambulances and fire engines seen rushing to the scene in Paris. The cordon becomes larger as people are asked to move back.
4.18pm: Local media reports that the Kouachi brothers have been killed in the raid on the printworks factory.
Sirens still audible in Dammartin-en-Goele, and there is an increase in activity in the immediate area.
4.20pm: Reports emerge that the Kouachi brothers’ hostage has been freed, and that several hostages who were being held in the kosher supermarket have also been released.
4.26pm: Police at supermarket siege in eastern Paris shout, “Get down,” and “We’ve got him,” amid gunfire exchanges, BFM-TV reports.
Police have reportedly told local broadcaster Europe1 that the supermarket hostage-taker and suspect in the policewoman murder was killed in the raid.
4.33pm: Amedy Coulibaly is believed to have been shot dead by police who stormed the building in Paris. It appears the assault took place around 10 minutes after the raid in Dammartin-en-Goele.
Images are now emerging of a group of people believed to be the supermarket hostages being escorted from the building.
4.44pm: Pictures from the scene of the siege show bright orange flames engulfing the Paris supermarket as police storm the building.
4.54pm: Emergency services flood the streets surrounding the scene in Paris.
Reuters claim that four hostages who were being held in the supermarket have died.
5.07pm: It appears as if the roads around the Dammartin-en-Goele building where the Kouachi brothers had been holed up have now reopened.
Traffic is now flowing through the area.
5.15pm: French president Francois Hollande announces he will address the nation at 7pm.
Security sources have reportedly said that four people were “critically wounded” when police stormed into the shop in Paris, bringing the siege to its end.
5.30pm: Reports emerge of a second male gunman in the kosher supermarket, who escaped in the assault. Hayat Boumeddiene’s location remains unknown.
6.55pm: In an address French president Francois Hollande calls for France to “remain vigilant” as he praises the “courage, bravery and efficiency” of the police forces that brought the hostage situations to an end.
7.08pm: An Israeli official says 15 hostages have been freed from the supermarket in Paris.
7.20pm: US president Barack Obama says he is hopeful that the immediate threat posed by terrorists in Paris has been now resolved. He says the situation remains fluid and that the French government continues to face the threat of terrorism.
8.55pm: A member of al Qaida’s branch in Yemen says the group directed the attack on Charlie Hebdo.
10.20pm: Paris prosecutor Francois Molins says an employee at the printing works where the Kouachi brothers were in Dammartin was hiding on the second floor underneath a sink. The brothers did not realise there was another person hiding in the warehouse. He also states Coulibaly and his girlfriend, Boumeddiene, spoke more than 500 times to the Kouachi brothers over the phone.
Saturday January 10th:
6.00am: French police say they are continuing to search for Boumeddiene.
9.30am: Broadcaster RTL releases extracts of Coulibaly ranting at hostages in the kosher store, captured after the hostage-taker unwittingly failed to hang up following a phone call. He said: “They must stop attacking the Islamic State, stop unveiling our women, stop putting our brothers in prison for nothing at all.”
11.20am: French prime minister Manuel Valls says the country must “never lower (its) guard” against terrorists. This came after an emergency meeting of France’s security agencies.


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Sund and Sea in downtown Athens
The opera-performance Sun and Sea by Rugilė Barzdžiukaitė, Vaiva Grainytė and Lina Lapelytė will be presented for two nights at 260 Piraeus Street, as part of the Athens and Epidaurus Festival
A sunny day on a dreamy, sandy beach. A host of bodies sunbathing, singing, telling their stories, talking in unison and becoming a Chorus. At the crossroads of theatre, music, and visual arts, the visually stunning opera-performance Sun and Sea highlights the connection between realism and poetry in an emotional manner. Or as curator Lucia Pietroiusti puts it: “A chorus of songs: everyday songs, songs of worry and of boredom, songs of almost nothing. And below them: the slow creaking of an exhausted Earth, a gasp”.
The magical scenery, the architecture of the space and the music compose a carefree buzz. A light choir that is slowly becoming more and more threatening as, as the author of the work, Vaiva Grainytė says: “In this pop and synthetic ocean of songs one can listen to the pulse of the threat. “The image of a happy holiday hides the consequences of inaction – the planet’s resources are consumed in sips.”
The performance represented Lithuania in the 2019 Venice Biennale, where it won the Golden Lion for Best National Participation.
The artistic team of Sun and Sea.
Rugilė Barzdžiukaitė is a theater and film director. Her artistic practice explores the distance between objective and imaginary reality, while her works lightly stylize the anthropocentric way of thinking. Her latest film, Acid Forest, won an award at the 2018 Locarno International Film Festival.
Vaiva Grainytė is a playwright and poet. Combining poetry with irony over time, he studies individual and collective memory, daily routine and issues of social interest.
Lina Lapelytė is a versatile creator, musician and composer. Her artistic practice focuses on music performance and deals with issues of pop culture and gender stereotypes.
The performance is accompanied by a poetic text in Greek and English that can be downloaded from the Festival website.
Conception – Development Rugilė Barzdžiukaitė, Vaiva Grainytė, Lina Lapelytė
Directed by Rugilė Barzdžiukaitė
Libretto Vaiva Grainytė
Translated by Rimas Užgiris
Musical composition and direction by Lina Lapelytė
Artistic curation by Lucia Pietroiusti
Tour producer Aušra Simanavičiūtė
Tour Coordination – Stage Direction Erika Urbelevič
Technical address Lique Van Gerven
Visual identity Goda Budvytytė
Conception – καιbäke catalog and vinyl design
Sound recording Romuald Chaloin Galiauskas
Live sound investment Salomėja Petronytė
Singers: Aliona Alymova, Marco Cisco, Auksė Dovydėnaitė, Saulė Dovydėnaitė, Claudia Graziadei, Artūras Miknaitis, Yates Norton, Vytautas Pastarnokas, Eglė Paškevičienė, Salomėja Petronytė, Kalliopi Petrou, Ieva Skorubskaitė, Svetlana Bagdonaitė, Nabila Dandara Vieira Santos.
Duration 1 hour
Production of Neon Realism
Coproduction Nidos Meno Kolonija / Vilniaus dailės akademija, Akademie Schloss Solitude Goethe-Institut, Münchner Kammerspiele, Nacionalinė dailės gallery – Vilnius, Staatsschauspiel Dresden, The Momentary, Arkansas
Sponsored by JCDecaux
Assignment Rasa Antanavičiūtė
Founding sponsors Lithuanian Cultural Council, Ministry of Culture of Lithuania, Laurenz Foundation in Basel, Vilnius Municipality


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text: Loved Blanco Tacos. I indicated in my online reservation that I am celiac. Waitperson made a point of saying the gluten free chips will be right out. Boy, did they get off on the right foot! I had a delicious grain bowl. Everything went smoothly. It was kind of noisy, that was only drawback.

domain: food


Darby Borough Citizen Water Quality Hotline: 911
New storm water regulations from Pennsylvania’s Department of Environmental Protection (DEP) require that our municipality investigate potentially illicit discharges into our streams as well as other events adversely affecting water quality.
YOU CAN HELP BY PROMPTLY CALLING 911 TO REPORT THE FOLLOWING EVENTS:
- Dumping, spills or other illicit (illegal) discharge into storm sewers or streams
- Sediment leaving a construction site during a rain event
- Observed pollution event or pollutants entering a stream
- Clogged sanitary sewer lines (evidenced by waste/toliet paper observed on a lawn or in street)
- Dry weather flows from outfall pipes into streams (a dry weather flow is water observed flowing out of a pipe when there hasn’t been any rainfall for a period of 72 hours or more)
- Fish Kills
- Water Main break
SANITARY SEWER BACKUPS
In the event of a sanitary sewer backup at your property, please call 911.
Although the Borough maintains its sewer system, periodic backups into homes or businesses may occur. In most cases, the Borough’s responsibility ends when the line is cleared and the problem causing the blockage has been addressed. Most homeowners’ insurance policies have optional riders for sewer backups that, if purchased will provide coverage.
MONTHLY STORM WATER TIPS: (2022)
- January 2022
- February 2022
- March 2022
- April 2022
- May 2022
- June 2022
- July 2022
- August 2022
- September 2022
UPCOMING STORM WATER EVENTS FOR BOROUGH RESIDENTS:
Please click the below link to learn what a Illicit Discharge is and how to report it.
Melting Ice Safely (Fact Sheet)
Trees: Stop the Tree Topping and Proper Mulching Techniques (Fact Sheet)
How to Create a Meadow Garden (Brochure)
Please click on the link below regarding Storm Water
Information for Builders to Prevent Stormwater Runoff
Builders and contractors working in our Borough need to follow certain procedures to prevent storm water pollution. Please familiarize yourself with the information in this flyer before applying for a building permit or starting any construction work in our community!
The State Department of Environmental Protection has a simple rule for what can enter Darby’s municipal storm water system: STORMWATER ONLY! State and federal clean water regulations, which Darby and other municipalities are required to follow, prohibit anything other than stormwater from entering the storm inlets found on most streets in the Borough.
What does this mean for you?
Here are some typical examples:
- After you mow your lawn, don’t blow or rake the clippings into the street. Rain water can wash them into the storm sewer system. Instead, bag them and place them on the curb for pick up by the Borough’s sanitation department on your next pick up day.
- If you spill a hazardous chemical, such as antifreeze, on your sidewalk or driveway, don’t wash it into the street. Use an absorbent material like kitty litter or rags to clean it up.
- If you are doing concrete work on your sidewalk, don’t wash excess material into the street or pour it directly into the storm sewer.
- If you are power washing your home, don’t use detergents if the wash water might enter the storm sewer system.
- If you are washing your car, try to use a non-toxic detergent and do the washing on the grass.
Stormwater is unavoidable, but its effects can be reduced by keeping harmful chemicals and materials out of the runoff. This section reviews potential sources of contamination and offers ways to minimize them. Click on the heading to read more. Then fill out the assessment table to help identify stormwater risks on your property.
These informational ads address different practices we all do on a daily basis, and give quick and easy ways to do them in a more water-friendly way. Check them out!
Here are some resources:
- Pennsylvania Department of Environmental Protection Stormwater Management
- Delaware County Conservation District
- Darby Creek Valley Association
- Stormwater Center
- Pennsylvania Environmental Council
- Stormwater Outreach Materials and Reference Documents
- NPDES Permit Program Basics
- National Menu of Stormwater Best Management Practice
- C-R-C website
- Philadelphia Water Dept. – Stormy Weather
- Beautiful Solutions to Water Pollution
- What is a Rain Garden?
- Rain Barrel Guide
- Permeable Pavers
- Landscaping & Lawn Care
- Used Oil Management Program
- Nonpoint Source Pollution Prevention
- Cigarette Butts
- Partnership for the Delaware Estuary
- Well Water Pollution
- Where to Recycle: Motor Oil, Antifreeze, Car Batteries, Tires & Scrap Metal: www.co.delaware.pa.us/recycle/auto.html
- Restoring Habitat: Landscape Structure and Health in Our Watersheds
- Integrated Pest Management


text:
It is a way for couples to express feelings of nurture, dominance, submission, self-actualization, etc. Psychologist, Robert Sternberg, would call their relationship romantic love Which of the following reflects a secure attachment style? Additionally, having a sense of intimacy helps create the feeling of being at ease with one another, in the sense that the two parties are mutual in their feelings.
I am ready sex date
She has two jobs and is attending a local college. What has the U. a)companionate love.b)infatuated love.c)fatuous love.d)consummate love.
Sternberg, consummate love may be harder to maintain than it is to. Pakistani college student According to Ginzberg's theory, the third stage which occurs in accorsing adulthood, when syernberg begin to explore specific career options, either through actual experience on the job or through training for a profession, and then narrow their choices and make a commitment is called realistic period What is the legal alternative to marriage in France in which couples receive many of the same legal rights as married couples without a legal lifetime commitment?
However, if a person shares a strong desire for intimacy and contact, as well as cares equally about the other's needs and their own, the person loves the other. A promise to be loyal to someone or something. Mita does not want to take medication for her stress, so the college therapist suggests that Mita try to increase contact with her friends as a means of decreasing her stress.
They've been going out two times a week for at least 4 months. Most importantly within his theory, he concludes that these three primary styles, like the making of complementary colors, can be combined to make secondary forms of love. According to the Spearmanian model, love is a single bundle of positive feelings.
Triangular theory of love
These kinds of love are combinations of one or two of the three corners of Sternberg's triangle of love. Rubin states that if a ti simply enjoys another's presence and spending time with them, that person only likes the other. Sternbrrg of the following terms describes what Tyrone is experiencing? Companionate love is also known as affectionate love. Sternberg's prediction of this love was that it would diminish as the relationship became less interrupted, thus increasing predictability.
This idea comes from Solomon's opponent-force theory. In this model, the various factors are equal in their contribution to the feeling, and could be disconnected from each other. There are three ways to define commitment: A promise to do or give something.
Sternberg also described three models of love, including the Spearmanian, Thomsonian, and Thurstonian models. Passionate love is not limited to sexual attraction, however. Forms of love[ edit ] Combinations of intimacy, passion, commitment. But, Tyler is confined to a wheel chair and accordimg office does not have access for him.
According to the Spearmanian model, love is a single bundle of positive as infatuated love and become romantic love as intimacy develops over time. Which of the following quotations addresses this issue? Another theory was introduced by Maslow.
According to Dr. She feels nervous and uncertain about what she should do. Passion can be associated with either physical arousal or emotional stimulation. Empty love is characterized by commitment without passion or intimacy. Something to note about commitment, however, is that one can be committed to someone without feeling love for him or her, and one can feel love for someone without being committed to him or her.
The decision to remain committed is mainly determined by the level of satisfaction that a partner derives from the relationship. The Spearmanian model is the closest to the triangular theory of love, and dictates that love is made up of equal parts that are more easily understood on their own than as a whole. This accordin of love is when the intimacy or liking component is present, but feelings for a deeper sense accordng intimacy, romantic love, or consummate love to develop.
Jorge has been taught to marry a woman who is younger, smaller, and lower in status.
Like most women there, she is unable to get promoted to anything higher than supervisor even though her work quality is excellent. Passionate love and companionate love are different kinds of love but are connected in relationships. Sternberg created his triangle next. Sternberg believed love to progress and evolve in predictable ways; that all couples in love will experience intimate, passionate, and committed love in the same patterns.
There is a chemical component to passionate love.
Related study materials
Intimacy is primarily defined as something of a personal or private nature; familiarity. Early theories of love[ edit ] One of the first theories of love was developed by Sigmund Freud. As Freud so frequently attributed human nature to unconscious desires, his theory of love centered around the need for an "ego robdrt.
Intimate love felt between two people means that they each feel a sense of high regard for each other. Due to her hectic schedule, she is experiencing several stressors that are contributing to physical ailments.
Psych ch 7 sg
The triangular theory of love is a theory of love developed by Robert Sternberg, a member of presence and spending time with them, that person only likes the other. A relationship based on a single element is less likely to survive than one based on two or three elements. They wish to make each other happy, share with each other, be in communication with each other, help when one is in need. According to Robert Sternberg, liking develops when only ______ is Robert Sternberg, companionate love develops when ______ is(are) present.a)intimacy and.
When a couple reaches this level of love, they feel mutual understanding and care accordimg each other.

domain: psychology