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Overview of latest articles and publications on gene therapy in PubMed, including Human Gene Therapy, Journal of Molecular Medicine and Journal of Gene Medicine. PubMed is a service of the US National Library of Medicine that includes over 18 million citations from MEDLINE and other life science journals.
- Host factors that promote retrotransposon integration are similar in distantly related eukaryotes.
Host factors that promote retrotransposon integration are similar in distantly related eukaryotes. [Journal Article]PLoS Genet 2017 Dec 12; 13(12):e1006775.PGRai SK, Sangesland M, Lee M, et al. Retroviruses and Long Terminal Repeat (LTR)-retrotransposons have distinct patterns of integration sites. The oncogenic potential of retrovirus-based vectors used in gene therapy is dependent on the se...Publisher Full TextRetroviruses and Long Terminal Repeat (LTR)-retrotransposons have distinct patterns of integration sites. The oncogenic potential of retrovirus-based vectors used in gene therapy is dependent on the selection of integration sites associated with promoters. The LTR-retrotransposon Tf1 of Schizosaccharomyces pombe is studied as a model for oncogenic retroviruses because it integrates into the promoters of stress response genes. Although integrases (INs) encoded by retroviruses and LTR-retrotransposons are responsible for catalyzing the insertion of cDNA into the host genome, it is thought that distinct host factors are required for the efficiency and specificity of integration. We tested this hypothesis with a genome-wide screen of host factors that promote Tf1 integration. By combining an assay for transposition with a genetic assay that measures cDNA recombination we could identify factors that contribute differentially to integration. We utilized this assay to test a collection of 3,004 S. pombe strains with single gene deletions. Using these screens and immunoblot measures of Tf1 proteins, we identified a total of 61 genes that promote integration. The candidate integration factors participate in a range of processes including nuclear transport, transcription, mRNA processing, vesicle transport, chromatin structure and DNA repair. Two candidates, Rhp18 and the NineTeen complex were tested in two-hybrid assays and were found to interact with Tf1 IN. Surprisingly, a number of pathways we identified were found previously to promote integration of the LTR-retrotransposons Ty1 and Ty3 in Saccharomyces cerevisiae, indicating the contribution of host factors to integration are common in distantly related organisms. The DNA repair factors are of particular interest because they may identify the pathways that repair the single stranded gaps flanking the sites of strand transfer following integration of LTR retroelements.
- Genomic form of rhodopsin DNA nanoparticles rescued autosomal dominant Retinitis pigmentosa in the P23H knock-in mouse model.
Genomic form of rhodopsin DNA nanoparticles rescued autosomal dominant Retinitis pigmentosa in the P23H knock-in mouse model. [Journal Article]Biomaterials 2017 Dec 05.:26-39.BMitra RN, Zheng M, Weiss ER, et al. Retinitis pigmentosa (RP) is a group of inherited retinal degenerative conditions and a leading cause of irreversible blindness. 25%-30% of RP cases are caused by inherited autosomal dominant (ad) muta...Publisher Full TextRetinitis pigmentosa (RP) is a group of inherited retinal degenerative conditions and a leading cause of irreversible blindness. 25%-30% of RP cases are caused by inherited autosomal dominant (ad) mutations in the rhodopsin (Rho) protein of the retina, which impose a barrier for developing therapeutic treatments for this genetically heterogeneous disorder, as simple gene replacement is not sufficient to overcome dominant disease alleles. Previously, we have explored using the genomic short-form of Rho (sgRho) for gene augmentation therapy of RP in a Rho knockout mouse model. We have shown improved gene expression and fewer epigenetic modifications compared with the use of a Rho cDNA expression construct. In the current study, we altered our strategy by delivering a codon-optimized genomic form of Rho (co-sgRho) (for gene replacement) in combination with an RNAi-based inactivation of endogenous Rho alleles (gene suppression of both mutant Rho alleles, but mismatched with the co-sgRho) into a homozygous RhoP23H/P23H knock-in (KI) RP mouse model, which has a severe phenotype of adRP. In addition, we have conjugated a cell penetrating TAT peptide sequence to our previously established CK30PEG10 diblock co-polymer. The DNAs were compacted with CK30PEG10-TAT diblock co-polymer to form DNA nanoparticles (NPs). These NPs were injected into the sub-retinal space of the KI mouse eyes. As a proof of concept, we demonstrated the efficiency of this strategy in the partial improvement of visual function in the RhoP23H/P23H KI mouse model.
- Prior systemic treatment increased the incidence of somatic mutations in metastatic breast cancer.
Prior systemic treatment increased the incidence of somatic mutations in metastatic breast cancer. [Journal Article]Eur J Cancer 2017 Dec 09.:64-71.EJFujii T, Matsuda N, Kono M, et al. Systemic treatment exposure is an independent risk factor for high rates of TP53 and PIK3CA mutation, which suggests the importance of testing samples after systemic therapy to accurately assess mutati...Publisher Full TextUnderstanding the biology of breast cancer is important for guiding treatment strategies and revealing resistance mechanisms. Our objectives were to investigate the relationship between previous systemic therapy exposure and mutational spectrum in metastatic breast cancer and to identify clinicopathological factors associated with identified frequent somatic mutations.Archival tissues of patients with metastatic breast cancer were subjected to hotspot molecular testing by next-generation sequencing. The variables that significantly differed (P < 0.05) in univariate analysis were selected to fit multivariate models. Logistic models were fit to estimate the association between mutation status and clinical variables of interest. Five-fold cross-validation was performed to estimate the prediction error of each model.A total of 922 patients were included in the analysis. In multivariate analysis, previous systemic treatment before molecular testing (N = 186) was associated with a significantly higher rate of TP53 and PIK3CA mutations compared with the lack of systemic treatment (P < 0.001 for both).Systemic treatment exposure is an independent risk factor for high rates of TP53 and PIK3CA mutation, which suggests the importance of testing samples after systemic therapy to accurately assess mutations. It is worth testing the gene profile when tumours become resistant to systemic treatments.
- MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma.
MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma. [Journal Article]Cancer Cell 2017 Dec 11; 32(6):840-855.e8.CCHuang T, Kim CK, Alvarez AA, et al. ATG4B stimulates autophagy by promoting autophagosome formation through reversible modification of ATG8. We identify ATG4B as a substrate of mammalian sterile20-like kinase (STK) 26/MST4. MST4 phosphor...ATG4B stimulates autophagy by promoting autophagosome formation through reversible modification of ATG8. We identify ATG4B as a substrate of mammalian sterile20-like kinase (STK) 26/MST4. MST4 phosphorylates ATG4B at serine residue 383, which stimulates ATG4B activity and increases autophagic flux. Inhibition of MST4 or ATG4B activities using genetic approaches or an inhibitor of ATG4B suppresses autophagy and the tumorigenicity of glioblastoma (GBM) cells. Furthermore, radiation induces MST4 expression, ATG4B phosphorylation, and autophagy. Inhibiting ATG4B in combination with radiotherapy in treating mice with intracranial GBM xenograft markedly slows tumor growth and provides a significant survival benefit. Our work describes an MST4-ATG4B signaling axis that influences GBM autophagy and malignancy, and whose therapeutic targeting enhances the anti-tumor effects of radiotherapy.
- [Systemic treatment of early breast cancer - current state of knowledge after the conference St Gallen 2017].
[Systemic treatment of early breast cancer - current state of knowledge after the conference St Gallen 2017]. [English Abstract, Journal Article, Review]Pol Merkur Lekarski 2017 Nov 23; 43(257):232-236.PMSarosiek T Breast cancer is the most commonly diagnosed malignancy in women around the globe. It is also the world's first cause of female deaths from cancer. With the introduction of screening programs in most d...Publisher Full TextBreast cancer is the most commonly diagnosed malignancy in women around the globe. It is also the world's first cause of female deaths from cancer. With the introduction of screening programs in most developed countries, more and more cases of this cancer are diagnosed at local or localized stages, enabling radical treatment to be successful. At the same time, systemic treatment of early breast cancer is one of the most complex issues in clinical oncology. Because of the many prognostic factors that need to be taken into account when considering eligibility for treatment such as age, reproductive status (before or after menopause), type of cancer and severity of the disease, it is impossible to establish clear standards of conduct for many clinical situations. The international biennial St Gallen conference, the world's most prominent breast cancer specialists, who are struggling to address major clinical problems in the treatment of early breast cancer. St Gallen's recommendations address all issues related to the treatment of early breast cancer (in particular surgery, radiotherapy, and systemic treatment) and are set by a group of 52 experts by voting. This method allows us to establish consensus on issues that can not be clearly identified in the results of randomized clinical trials. In this way, more than 200 clinical issues were answered. The most important changes in day-to-day practice are the duration of ajuvant hormone therapy (10 instead of 5 years), the possibility of using aromatase inhibitors (in combination with ovarian function suppresion) in premenopausal women with high risk of recurrence and the timing of sentinel node biopsy after neo-adjuvant chemotherapy. There are also recommendations, which patients should undergo genetic testing to assess the risk of recurrence of breast cancer.
- Whole-exome sequencing of oral mucosal melanoma reveals mutational profile and therapeutic targets.
Whole-exome sequencing of oral mucosal melanoma reveals mutational profile and therapeutic targets. [Journal Article]J Pathol 2017 Dec 12.JPLyu J, Song Z, Chen J, et al. Oral mucosal melanoma (OMM) is rare and aggressive subtype of melanoma with little known about its pathogenesis carcinogenesis. We therefore performed whole-exome sequencing (WES) on 19 matched OMM tum...Publisher Full TextOral mucosal melanoma (OMM) is rare and aggressive subtype of melanoma with little known about its pathogenesis carcinogenesis. We therefore performed whole-exome sequencing (WES) on 19 matched OMM tumor/normal pairs in order to gain insight on potential genetic drivers of tumor formation. For the first time we describe the comprehensive mutational profile of OMM. Our data suggests that the genetic background of OMM differs from those of other melanoma subtypes. We identified recurrent mutations involving KIT, POLE,PTPRD, PTCHD2 and DMXL2. Notably, copy number analysis revealed recurrently amplified regions of 12q14 (57.9%, containing CDK4) and 5p15 (47.4%, containing TERT). CNV analysis in a separate cohort of 15 samples validated the frequent CNV in CDK4 and TERT. We also observed that the melanocyte development and pigmentation signaling pathway is frequently altered in OMM. Furthermore, our data suggest several altered genes that may be amenable for targeted therapy. We identified one patient with metastatic OMM in our cohort who was identified to harbor a targetable KIT mutation using our WES results. This patient was able to achieve complete remission following implementation of KIT-targeted therapy. These findings provide further insight into the genetic underpinnings of OMM development and suggests that patients with OMM may benefit from WES analysis to identify potential targetable genetic mutations.
- Potential Effects of Horizontal Gene Exchange in the Human Gut.
Potential Effects of Horizontal Gene Exchange in the Human Gut. [Journal Article]Front Immunol 2017.:1630.FILerner A, Matthias T, Aminov R Many essential functions of the human body are dependent on the symbiotic microbiota, which is present at especially high numbers and diversity in the gut. This intricate host-microbe relationship is a...Many essential functions of the human body are dependent on the symbiotic microbiota, which is present at especially high numbers and diversity in the gut. This intricate host-microbe relationship is a result of the long-term coevolution between the two. While the inheritance of mutational changes in the host evolution is almost exclusively vertical, the main mechanism of bacterial evolution is horizontal gene exchange. The gut conditions, with stable temperature, continuous food supply, constant physicochemical conditions, extremely high concentration of microbial cells and phages, and plenty of opportunities for conjugation on the surfaces of food particles and host tissues, represent one of the most favorable ecological niches for horizontal gene exchange. Thus, the gut microbial system genetically is very dynamic and capable of rapid response, at the genetic level, to selection, for example, by antibiotics. There are many other factors to which the microbiota may dynamically respond including lifestyle, therapy, diet, refined food, food additives, consumption of pre- and probiotics, and many others. The impact of the changing selective pressures on gut microbiota, however, is poorly understood. Presumably, the gut microbiome responds to these changes by genetic restructuring of gut populations, driven mainly via horizontal gene exchange. Thus, our main goal is to reveal the role played by horizontal gene exchange in the changing landscape of the gastrointestinal microbiome and potential effect of these changes on human health in general and autoimmune diseases in particular.
- Ibalizumab Targeting CD4 Receptors, An Emerging Molecule in HIV Therapy.
Ibalizumab Targeting CD4 Receptors, An Emerging Molecule in HIV Therapy. [Journal Article, Review]Front Microbiol 2017.:2323.FMIacob SA, Iacob DG The HIV infection is responsible for the most devastating global pandemic of the last century. More than 39 million people have died of HIV/AIDS since 1981. The development of the antiretroviral (ARV) ...The HIV infection is responsible for the most devastating global pandemic of the last century. More than 39 million people have died of HIV/AIDS since 1981. The development of the antiretroviral (ARV) treatment begins with the discovery of zidovudine a nucleoside reverse transcriptase inhibitor. This breakthrough was followed by other ARV drug classes and representatives. Presently, HIV treatment employs 27 ARV representatives belonging to five different classes. Despite the proven benefits of ARV treatment and its long-term control of the HIV infection, there is an increasing concern about the numerous adverse effects and resistance to current ARV drugs. Therefore, the new HIV treatment strategies focus on the development of new ARV agents with a high genetic barrier to resistance and low toxicity. Monoclonal antibodies (MAbs) belong to a new drug class with encouraging results in the treatment of cancer, autoimmune disorders and most recently against HIV infection. The advantages of using MAbs for HIV treatment are related to their antiviral effect, lack of toxicity, good resistance profile, additional synergy with other ARV drug classes and ability to restore CD4 T-cell responses. The current article is a short summary of ibalizumab, an anti-CD4 monoclonal antibody that interferes with HIV viral entry. Current studies on ibalizumab have underlined its antiviral potential, minimal adverse effects, and lack of crossed resistance with other ARV agents thus supporting its further therapeutic use in multidrug resistant HIV-infected patients.
- Molecular Targets in Non-Small Cell Lung Cancer.
Molecular Targets in Non-Small Cell Lung Cancer. [Journal Article, Review]Ochsner J 2017; 17(4):388-392.OJGriffin R, Ramirez RA Patients with advanced NSCLC should undergo mutational testing to evaluate for actionable mutations. If such a mutation is discovered, targeted therapy should be considered for first-line treatment.Lung cancer is the second most common cancer in the United States among men and women, and it is the most common cause of cancer-related death. Non-small cell lung cancer (NSCLC) represents approximately 85% of all lung cancer cases. Historically, patients with metastatic NSCLC received similar cytotoxic chemotherapy regimens. Genotyping studies have revealed genetic/molecular abnormalities in lung cancer. These driver mutations render a cancer dependent on that specific mutation's biochemical pathway for its growth and survival. With the development of tyrosine kinase inhibitors and antibodies against specific driver mutations, the landscape of lung cancer treatment has changed from treatment based on histologic subtype to treatment based on molecularly defined subtypes.In this article, we review the current molecular-targeted therapies in lung cancer.We review landmark trials that have led to approval of molecular-targeted therapies against epidermal growth factor receptor, anaplastic lymphoma kinase, and ROS1. We also explore less common mutations/molecular abnormalities and review data on the use of targeted therapies against them. Finally, we offer a treatment algorithm for patients with metastatic NSCLC that harbors actionable mutations.Patients with advanced NSCLC should undergo mutational testing to evaluate for actionable mutations. If such a mutation is discovered, targeted therapy should be considered for first-line treatment.
- Antifolate drug resistance: Novel mutations and haplotype distribution in dhps and dhfr from Northeast India.
Antifolate drug resistance: Novel mutations and haplotype distribution in dhps and dhfr from Northeast India. [Journal Article]J Biosci 2017 Dec; 42(4):531-535.JBSarmah NP, Sarma K, Bhattacharyya DR, et al. Malaria is a major public health concern in Northeast India with a preponderance of drug-resistant strains. Until recently the partner drug for artemisinin combination therapy (ACT) was sulphadoxine py...Publisher Full TextMalaria is a major public health concern in Northeast India with a preponderance of drug-resistant strains. Until recently the partner drug for artemisinin combination therapy (ACT) was sulphadoxine pyrimethamine (SP). Antifolate drug resistance has been associated with the mutations at dihydropteroate synthase (dhps) and dihydrofolatereductase (dhfr) genes. This study investigated antifolate drug resistance at the molecular level. A total of 249 fever cases from Arunachal Pradesh, NE India, were screened for malaria, and of these, 75 were found to be positive for Plasmodium falciparum. Samples were sequenced and analysed with the help of BioEdit and ClustalW. Three novel point mutations were found in the dhps gene with 10 haplotypes along with the already reported mutations. A single haplotype having quadruple mutation was found in the dhfr gene. The study reports higher degree of antifolate drug resistance as evidenced by the presence of multiple point mutations in dhps and dhfr genes. The findings of this study strongly discourage the use SP as a partner drug in ACT.

domain: medical


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domain: health


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Preheat your oven to 425. Wash and peel (optional) the parsnips and trim the ends off. Slice into french fry sized pieces – 1/2 inch wide by about 4 inches.
Toss to coat the parsnip fries with olive oil and season with salt, pepper, and garlic powder.
Lay on a parchment lined baking sheet and roast for 20-22 minutes, turning once halfway through. *Watch closely for burning ends as it gets close to the end of the cook time.
Prep the Toppings
Bacon: Cook the bacon in a skillet over medium heat until crispy. Drain on a paper towel and allow to cool a bit before roughly chopping.
Horseradish Sauce: Mix all ingredients together and season to taste. Add more lemon juice or a drop of water to thin the mixture, if needed. Cover and refrigerate until you're ready to serve it.
Chives: Wash and thinly slice the chives.
Assemble and Serve
Arrange the fries on a plate. Drizzle with the horseradish sauce, sprinkle the crumbled bacon, and top with chives. Season with salt and pepper and enjoy!
Variations: For a low carb option, substitute turnips or rutabaga.
Please note that the nutritional information may vary depending
on the specific brands of products used. We encourage everyone to check specific
product labels in calculating the exact nutritional information.

domain: food


Fujitsu Frontech launches a new UHF RFID garment tag for clothing and uniform rental markets
New garment tag enables fast, low cost installation with existing heat seal labels
Tokyo, October 29, 2020 – Fujitsu Frontech Ltd. announced it has newly developed a UHF RFID garment tag that enables garment, uniform and workwear rental companies to easily migrate their business to include the efficiencies of UHF RFID to realize sophisticated garment tracking and asset management. In some healthcare institutions suffering from COVID-19, there is a movement to reuse hospital uniforms and others instead of throwing them away, so in order to manage them strictly, the demand for contactless and bulk readable RFID solutions is growing. We will launch this product globally starting with Japan and North America with other regions to follow. The new, low cost, garment tag is so thin, it can easily be attached to rental garments including uniforms and work clothes using existing heat seal labels or attached with a sew-on label or pouch. Fujitsu Frontech provides UHF RFID tags in total in conjunction with readers/writers and data management cloud platforms.
Unlike other UHF RFID washable tags, the new Fujitsu garment tag is only 0.6mm thick, so that it can be easily attached to a garment unobtrusively. The tag is designed for typical garment industrial laundry and dry-cleaning equipment and process. As with Fujitsu linen tags, the garment tag uses advanced antenna technology that allows for reading hundreds of items while reducing mis-reads of nearby tags.
Fujitsu washable tags drive efficiency in the garment rental industry by simplifying inventory management, tracking garments through the laundry process, improving inventory accuracy, while reducing costs associated with incorrect shipments.
The new garment tags have an adhesive backing allowing the tag to be placed directly on the heat seal label before being attached to the garment. This eliminates mis-attaching labels and costly rework. Users can continue to use their existing heat seal label equipment and labels. For ease of use, tags are attached on a release-paper roll to simplify operator handling.
Fujitsu washable UHF RFID tag technology is already widely used for individual linen management in various businesses throughout the world, such as hospitals and healthcare facilities, hotels, food and beverage, garment and linen rental service providers, transportation and distribution services, and entertainment and amusement companies. The new garment tag will make RFID technology applicable to markets where low cost and fast attachment are required.
- Achieved thickness of 0.6mm
We achieved a tag thickness of 0.6mm, allowing the tag to be attached inconspicuously to a variety of rental clothes.
- Maintaining durability required in the garment market
It has durability to withstand about 100 cycles of typical garment industrial laundry and dry-cleaning process (excluding high pressure water extractors).
- Realized stable communication performance and low prices
Fujitsu’s state-of-the-art antenna technology realized stable communication performance that is not impacted by the common problems associated with RFID tag technology, including distance, variations in quality, and deterioration by washing.
- Low cost
Fujitsu’s fully automated mass production manufacturing systems allow for low cost tags.
Main Items to be Attached
Uniforms, Worker Wear, Shirts, Slacks, Shoes and Accessories (for food and beverage providers, manufacturing plants, healthcare institutions, hotels, etc.).
Price and Launch Date, and Shipping Date
|Product name||Price(w/o tax)||Launch date||Shipping date|
|TFU-TD2BxB (For Japan only)||Open price||October 29||The End of November|
|WT-A533G (For Korea and overseas)||Open price||October 29||The End of November|
We are targeting to sell 30 million garment tags in the next 3 years (including Japan and overseas).
UHF RFID tags product pagehttps://www.fujitsu.com/jp/group/frontech/en/solutions/business-technology/intelligent-society/rfid/
About Fujitsu Frontech
As part of the Fujitsu Group, Fujitsu Frontech Limited ties people and ICT together through the development, manufacture and sales of front-end technologies such as ATMs, banking terminals, palm vein authentication system, RFID, and totalizator terminals. Fujitsu Frontech also offers related software, system integration and services as part of its total solutions. Fujitsu Frontech Limited (TSE: 6945) reported consolidated revenues of 91 billion yen (US$834 million) for the fiscal year ended March 31, 2020. For more information, please see https://www.fujitsu.com/jp/frontech/en/.
FUJITSU FRONTECH CHUNGHO GLOBAL PRODUCTS
Product planning Tel: +82-2-3670-7788 (direct) Office hour: 9am-5pm (except Saturday, Sunday, and National holidays)
Please refer to below for relevant information of our affiliated company FUJITSU KOREA LIMITED.


The Trial of the Chicago 7 has garnered up plenty of buzz this awards season. It remains to be seen if the movie has what it takes to land Oscar nominations next month, but he Golden Globes already nominated the movie for Best Motion Picture – Drama, not to mention nominations for Aaron Sorkin as a writer and director. Now Netflix is making sure everyone sees all the hard work that went into the true story of one of the most notorious trials in history with a nearly 30-minute featurette.
Making of The Trial of the Chicago 7
Writer/director Aaron Sorkin is joined by cast members Sacha Baron Cohen, Yahya Abdul-Mateen II, Frank Langella, Eddie Redmayne, Mark Rylance, Joseph Gordon-Levitt, Michael Keaton, Jeremy Strong, and more to take a closer look at the making of this timely courtroom drama that resonates with the dramatic events that unfolded across the summer of 2020. You’ll find out about Sorkin’s approach to the material, how the cast worked with the filmmaker on his sophomore directing effort, and how certain sequences were carried out on-location in Chicago.
The movie is produced by Marc Platt, Stuart Besser, Matt Jackson and Tyler Thompson with a long list of executive producers that includes Laurie MacDonald, Walter Parkes, Marc Butan, Anthony Katagas, James Rodenhouse, Nia Vazirani, Kristie Macosko Krieger, Maurice Fadida and Shivani Rawat.
What was intended to be a peaceful protest at the 1968 Democratic National Convention turned into a violent clash with police and the National Guard. The organizers of the protest—including Abbie Hoffman, Jerry Rubin, Tom Hayden and Bobby Seale—were charged with conspiracy to incite a riot and the trial that followed was one of the most notorious in history.
The Trial of the Chicago 7 is available to watch on Netflix right now.
The post VOTD: Go Inside the Making of Aaron Sorkin’s ‘The Trial of the Chicago 7’ with a Nearly 30-Minute Featurette appeared first on /Film.


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Book Rating: 4 ½ out of 5 Stars
Audiobook Rating: 5 out of 5 Stars (Highest Rating)
Bottom Line: This book delivers a quintessential piece of 19th Century horror / sci fi that presents some challenging moral quandaries.
(Spoiler warning for this paragraph, assuming that applies to a work as well known as this one.) In this classic 19th Century tale, a lawyer–Gabriel John Utterson–finds himself entangled in the affairs of his friend, the upstanding Dr. Henry Jekyll, along with a rather surly dwarf of a man known as Mr. Hyde. The latter, a person of loathsome appearance and demeanor, has been seen around town and was guilty of assaulting a girl, which Dr. Jekyll later paid retribution for. Hyde has an unspecified connection with the doctor and Utterson is particularly dismayed when Jekyll revises his will to include Hyde as a beneficiary. This all comes to a head when a man is violently murdered and Mr. Hyde is linked to the crime, becoming a fugitive from justice. Utterson tries to talk with Jekyll about the situation, but the doctor assures his friend that the beastly man will not return. Later, though, Jekyll withdraws from almost all human contact prompting his butler to seek Utterson’s aid. They eventually break into Jekyll’s quarters and find the dead body of Mr. Hyde, though in the doctor’s clothes. They also find a letter written by Dr. Jekyll that describes his experiments in which he tried to separate his good side from his evil side but which instead produced the alter ego Mr. Hyde. Jekyll could at first control the transformations, but later found that he would morph involuntarily into Hyde. And then he found that he could no longer recreate the potion that prompts the metamorphosis because the key (tainted) ingredient he had previously used no longer exists. Eventually both personalities succumb to death and in his dying words Jekyll writes (as he transforms for the final time into Hyde) “I bring the life of that unhappy Henry Jekyll to an end”.
This infamous novella written by Robert Louis Stevenson was first published in 1886 and has since become an iconic piece of genre fiction and has been retold countless times in film, on television, in comics, on the stage and more. The reason the story has lived on is that Stevenson managed to deliver a powerful tale that resonates with his readers and definitely touches a primal nerve. The first nine chapters of the book, written from the point of view of Utterson, give us a mystery tale as the lawyer tries to find out the truth about Mr. Hyde and his connection to Dr. Jekyll. But it is the final chapter that propels this book into the realm of literary masterpiece. This chapter unveils the final journal of Dr. Jekyll as he details his experiment and descent into the depths of his own dark side. But instead of simply looking at this from the simplistic point of view of good vs. evil, Stevenson adds another dimension to his tale by acknowledging the fact that both sides co-exist within us all and that we must learn to cope with our own dark sides in order to not be controlled by it. Jekyll tried to control his own licentiousness by devising a means to eradicate his dark side, but instead that created the Mr. Hyde alter ego. And this evil side of him gradually overtook the good side and ultimately destroyed both. Stevenson gets into some pretty heady (and cutting edge for the time) psychological territory in this chapter, and the moral issues he raises still provide subject for debate today.
I have to admit, though, that I found the ending a bit unsatisfying. After the revelations of the final chapter, all written in the words of Jekyll, I wanted to see the reaction of Utterson as well as some additional resolution of earlier plot threads left hanging. But that did not come as the novella ends on Jekyll’s words quoted above. On the plus side, this tale is not overly wordy like other important genre works from the 19th century such as Dracula and Frankenstein. The relatively brief length of this book makes it a quick read, unlike the two mentioned above (or the thousand-plus page bloatfests we currently see hitting the shelves these days), but a short chapter wrapping up the loose ends would have been nice. But then that’s just a quibble and who am I to try and perfect a literary masterpiece?
Dr. Jekyll and Mr. Hyde is often looked at as a horror story, but the fact is that it is also a proto-science fiction tale as well. Jekyll’s experiments that lead to the creation of Mr. Hyde come about through scientific endeavors and have no supernatural links. In this sense, the book is similar to Mary Shelley’s Frankenstein which based the creation of that book’s monster on scientific knowledge of the time. Stevenson also works in some of the early discoveries of psychology, a field that had established itself as a new scientific discipline at about that same time (separating itself from philosophy where it had previously been relegated). But whether you consider it horror, science fiction or both, it is a must-read for all genre fans.
Since Dr. Jekyll and Mr. Hyde is in the public domain, there are many audio adaptations and dramatizations available for this work, but I decided to check out the Librivox version and was pleasantly surprised. For those not familiar with Librivox, they are the Project Gutenberg of audiobooks, offering free audio adaptations of works in the public domain available for download. This is one of several audiobooks from Librivox I have listened to and the others were of varying quality as far as narration goes. But the version of Stevenson’s book gets the first-rate treatment, with narrator David Barnes giving us a professional quality reading. Whereas some of the readers for Librivox (all volunteers) provide barely passable narrations, Barnes delivers an excellent vocal performance and makes the story a pleasure to listen to. Why pay good money for a professional adaptation when you can get one just a good for free from Librivox? You can download it as MP3 files at this link and I highly recommend this version whether you are a regular audiobook listener (used to a professional level of quality) or just trying them out for the first time.
Sci Fi Frontiers is a collaborative website for lovers of sci fi, fantasy, and horror. We welcome you to join our community and contribute articles, fiction, films, comics, artwork and more and/or promote your genre projects. Find out how to join at this link.

domain: library


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Asia’s Songbird Regine Velasquez said she tends to be “choosy” when it comes to movie projects, noting that it is not her forte.
Velasquez admitted that she usually feels uncomfortable when doing films.
“I get uncomfortable… Bago ko gawin ‘yung project, talagang kailangan kong i-psyche ‘yung sarili ko. Mahirap ha, kasi I have to wake up in the morning being a different person,” she said.
Velasquez was quick to add, however, that she also enjoys being a movie actress.
“Siyempre, I end up enjoying it. Pero before that, lagi akong hesitant because I am not an actor. I am a singer,” she said.
“I want to accept projects na I am sure I can do, like rom-com,” she added. “Depende siguro din kung may role pa na babagay sa akin.”
When asked about her preferred leading man should she star in a movie again, Velasquez said: “Hindi ko alam. Kasi nga, parang hindi ko masyadong iniisip eh. So hindi ko alam unlike before na parang once a year kailangan kong mag-movie so naghahanap na agad ako [ng actor].”
Velasquez starred in hit films like “Wanted: Perfect Mother,” “Dahil May Isang Ikaw,” “Kailangan Ko’y Ikaw,” “Till I Met You” and “Pangako Ikaw Lang.” (MNS)

domain: entertainment


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And just like that Starfish and Coffee Radio turns 25 episodes old! Thanks to everyone who has listened and supported the show!
Little Beat and DJ Starfish put together a wild musical ride on the November 26th show, with music from a young Michael Jackson, The Beatles, Yo Gabba Gabba, Aretha Franklin and more!
Please note that we had some recording issues and so the show's intro over Prince's 'Starfish and Coffee' did not make it into episode 25's podcast.
1. Prince - Starfish and Coffee (show theme)
2. Michael Jackson - Rockin' Robin
3. Sister Sledge - We Are Family
4. Aretha Franklin - Rock Steady
5. CHIC - Good Times
6. Kurtis Blow - The Breaks
7. Ramones - Surfin' Bird
8. The Beach Boys - Surfin' Safari
9. Gloria Estefan & the Miami Sound Machine - Conga
10. Yo Gabba Gabba w. Weird Science - Go Crazy Remix
11. The Boomtang Boys - Popcorn - Microwave Mix
12. Vanilla Ice - Ice Ice Baby
13. David Bowie & Queen - Under Pressure
14. Talking Heads - Once In A Lifetime
15. Feist - 1234
16. K'NAAN - Wavin' Flag
17. The Beatles - Ob-La-Di, Ob-La-Da


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On another note, changes to one’s lifestyle may be enough to deal with or reduce anxiety in some cases – especially mild ones. One of the most common experiences during a hangover is paranoia feelings that something bad must have happened because of how bad one feels.
Dependence refers to the process by which your mind and body come to depend on a substance so you keep feeling a certain way. This tends to result in withdrawal symptoms when you stop using the substance. For those seeking addiction treatment for themselves or a loved one, the addictionresource.com helpline is a private and convenient solution. Our writers and reviewers are experienced professionals in medicine, addiction treatment, and healthcare. AddictionResource fact-checks all the information before publishing and uses only credible and trusted sources when citing any medical data. The Verified badge on our articles is a trusted sign of the most comprehensive scientifically-based medical content.
- Typically, people become dependent on something because its ingestion becomes associated with the alleviation of mental duress.
- Depending on the amount and duration of drinking and any symptoms, detoxification (often simply called “detox”) from alcohol can be done as an outpatient, or as an inpatient in a hospital or drug treatment facility.
- This addiction can dominate all areas of life in a detrimental way, yet the affected person is unable to control or easily quit using alcohol.
- Another notable difference is that most stimulant users will go through psychological withdrawal, rather than a physical one when they cease to use drugs.
- In common cases, the system is used by judges to help them determine sentences for drug-related crimes.
- A doctor or substance abuse expert may be able to help a person look at the consequences of drinking.
Addictions manifest themselves as uncontrollable cravings to use drugs, despite doing harm to oneself or others. Teens and adults with mental disorders are more likely to develop substance abuse patterns than the general population. When a person succumbs to the grip of an addiction, it is extremely difficult to quit on their own.
Recognizing And Understanding Addiction
Another notable difference is that most stimulant users will go through psychological withdrawal, rather than a physical one when they cease to use drugs. What this means, is that they will usually experience cravings and strong desires to use again.
When you begin using drugs, your initial euphoric feelings are tied into the places and situations in which you use them. However, they can be very upsetting, and may even lead you back down the road to relapse.
These symptoms occur due to changes in the brain and central nervous system, which are a result of chronic substance abuse. Addiction, on the other hand, is a behavioral syndrome characterized by the compulsive and repeated seeking out or usage of a drug in spite of negative physical, psychological and/or social consequences. Along Alcohol abuse with this comes the physical need for more and more of a drug to get the desired high. With addiction often comes physical dependence, tolerance, and withdrawal syndrome. Many therapies for psychological addiction are usually offered in aftercare programs for patients who want ongoing treatment to maintain lifelong sobriety.
For example, if you are addicted to gambling, you’ll solely suffer from an intense psychological urge to gamble. If, on the other hand, you’re addicted psychological dependence on alcohol to a substance like a specific drug or type of spirit, you’ll usually first develop a psychological addiction and then a physical one.
Here Are Common Physical And Behavioral Addiction Types:
Understanding how a substance abuse problem develops helps to shed light on why they are so hard to beat. Learn about what addiction is, the signs to look out for and related topics below. In case we haven’t covered everything you wanted to know when it comes to physical addiction to alcohol, you are welcome to post your questions below. We guarantee that the answer you’ll receive will be personal delivered to you as soon as possible. If you wish to explore additional treatment options or connect with a specific rehab center, you can browse top-rated listings, visit our homepage and browse by state, or visit SAMHSA. For those seeking addiction treatment for themselves or a loved one, the Addictionblog.org helpline is a private and convenient solution.
We follow strict guidelines when fact-checking information and only use credible sources when citing statistics and medical information. Look for the medically reviewed badge on our articles for the most up-to-date and accurate information. Contact us at The Recovery Village to learn more about our treatment programs for substance use disorder. Our trained staff will help walk you through how you can get started on the road to recovery today and what to expect during your experience. Understanding both physical and psychological addiction, how they work and how they go hand-in-hand is important for treatment. DrugAbuse.gov offers an insightful explanation based on brain image studies from people addicted to drugs. The study found, physical changes in areas of the brain that are critical for judgment, decision making, learning, memory, and behavior control in addicted people.
It is very important to get treatment for such disorders if they are contributing to the problem. After detoxification, many people with alcohol disorders need some form of long-term support or counseling to remain sober.
But these may be easier for concerned family members and friends to ask, since they may hesitate to ask direct questions about quantity. Considered by some people to be a taboo subject, there is a far greater understanding of addiction among both laymen and professionals psychological dependence on alcohol nowadays. You’re suffering from an illness, and you need to get treatment for it as soon as you possibly can. It is true that your brain and your body will react very differently to stimulants, such as meth and cocaine than it will to depressants like heroin and alcohol.
When you stop using the substance, you experience physical symptoms of withdrawal. All of these risks are potentially fatal to the user, and the temporary stress relief that the substance may bring is a mild positive in comparison. A consequence of this behavior is an eventual increase psychological dependence on alcohol in the frequency and severity of angst symptoms. So while addiction to alcohol and anxiety attacks are a thing, it may be that people with anxiety disorders are more likely to drink. It’s common to sweep the thought of addiction under the carpet, and not to talk about it.
Symptoms Of Physical Addiction
The substance is used in larger amounts or over a longer time than the person originally intended. Many individuals with addictive disorders are aware of their problem, but have difficulty stopping on their own. For more information on AAC’s commitment to ethical marketing and treatment practices, or to learn more about how to select a treatment provider, visit our About AAC.
For anyone living with alcoholism or alcohol anxiety disorders, it is best to seek treatment from a certified healthcare professional as soon as possible. People living with depression or other related mental disorders are more likely to experience hangxiety than anyone else. This is because ethanol suppresses those feelings while they are “high,” and when the dopamine levels go back to normal, the rebound effect is far greater than it would be for a person with no mental health disorder. About 30% of people with alcohol use disorder are able to abstain from alcohol permanently without the help of formal treatment or a self-help program. Two of three people seeking treatment do reduce their intake and improve their overall health. Some people will go through periods where they remain sober, but then relapse. Depression and anxiety frequently occur along with an alcohol use disorder.
With repeated, consistent abuse, alcohol and drugs can alter functions in the brain and central nervous system, and go on to trigger physical dependence. An individual is physically addicted to drugs and alcohol when they require these substances to avoid cravings, nausea, and other withdrawal symptoms. Alcohol dependence is a problem that not only affects the alcoholic, but family members, friends and loved ones. It’s vital for the benefit of your health, personal life, and loved ones to seek treatment immediately.
In addition to the uncomfortable bodily changes associated with a hangover, withdrawal itself can cause anxiety, hallucinations, and panic attacks. Heavy drinkers can suffer from severe withdrawal symptoms after drinking, some of which can be life-threatening. These effects can also be dangerous for the people around the drinking individual. The resulting panic attacks and hallucinations can be terrible, and withdrawal seizures can be lethal. After weaning from alcohol, medication in some cases can help reduce cravings. Two medications that fit in this category are naltrexone and acamprosate. Disulfiram does not reduce craving, but it creates an incentive not to drink, because drinking alcohol while taking it causes nausea and vomiting.
Alcohol anxiety after a long night of drinking is more common than one would imagine. In the next two sections, we discuss the effects of hangover and withdrawal. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products.
CBT helps patients identify and overcome negative behaviors and thought-processes driving their addiction. Families affected by addiction can learn more about causes and behaviors associated with addiction so they can help their loved ones achieve lasting sobriety. Group therapy allows patients to bond with others in recovery who share similar struggles with addiction, and to openly discuss their thoughts and emotions surrounding addiction. This addiction type involves the performance of dangerous high-risk activities such as having unprotected sex with strangers and driving while intoxicated.
Author: Timothy Legg


“Cupetino city officials Thursday night held a public meeting to start the Environmental Reveiw process for a new home for Apple,” KTVU reports.
“Apple’s plans call for a 3.1 million square foot building – four stories high and round,” KTVU reports. “People broke up into smaller groups Thursday night to talk about issues that should be included in the Environmental Impact Report. Cupertino officials will incorporate those ideas into a draft Environmental Impact Report that will then undergo further public review.”
“‘Is it a done deal? It’s definitely not a done deal,’ said Cupertino Mayor Gilber Wong. ‘We have to go through a public process,'” KTVU reports. “That could take a year, and would culminate with a City Council vote on the EIR.”
Read more in the full article here.
MacDailyNews Take: Regardless of what Gilbert is saying this minute or next, there is no deal more done.
(Although, if any state could eff something like this up, it would have to be California.)
Cupertino City Council to examine environmental impact of Apple’s new Mothership campus – September 7, 2011
City of Cupertino posts further details on Apple mothership campus – August 13, 2011
Cupertino area residents greet Apple’s proposed mothership campus with enthusiasm – June 20, 2011
Apple’s new ‘Mothership’ campus: Full details and gallery – June 16, 2011
Cupertino mayor: ‘There is no chance we are saying no’ to Apple Mothership (with video) – June 9, 2011
Steve Jobs presents giant 12,000 employee ‘spaceship’ campus to Cupertino City Council (with video) – June 8, 2011


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Jennie provides counsel to the executive team on a variety of legal and strategic matters.
Jennie previously served as a Vice President at Windstream Communications. As a senior member of the General Counsel’s team, she provided legal and public policy advice to corporate executives on a wide variety of business initiatives. Jennie’s contributions during her decade at the company included attaining and protecting substantial government funding for broadband networks; achieving approval for mergers and acquisitions; and improving employment engagement as manager of a team spread across the continental United States.
Before joining Windstream, Jennie was appointed by California Governor Arnold Schwarzenegger to serve as Advisor on Policy and Planning at the California Public Utilities Commission. Her state government work included leading the development of the Governor’s Executive Order on Twenty-First Century Government: Expanding Broadband Access and Usage in California (EO S-23-06), drafting the PUC decision that created California’s first-ever state video franchise regulatory regime, and managing cross-agency efforts to advance deployment of enhanced 911 services for VoIP customers.
Jennie’s prior work experience includes serving as a John Gardner Fellow in the office of FCC Commissioner Kathleen Q. Abernathy and a Sand Hill Fellow in the Program for the Study of Entertainment Media and Health at the Kaiser Family Foundation.
Civic and Board Involvement
Jennie volunteers her time as a mediator for community and small claims court matters, and supports her children’s grade school in a variety of capacities, including recently serving as co-chair for the school’s annual carnival. She also is a John Gardner Public Service Fellowship class chair. Her prior volunteer work within the Federal Communications Bar Association included serving as a Northern California Chapter chair and as a Moot Court Committee chair.

domain: law


text:
Residential design is near and dear to my heart. This design is not about my own personal style, but figuring out what you love and helping you pull it off. Not that I won't have tons of opinions but I have to be sure it reflects you, the client, first and foremost! So if you are traditional, transitional, contemporary, whatever----we will figure it out and make it happen! And I am realistic that not everyone will have the money to do it all at once. So for some clients we work in stages and set you up on a master plan!
in progress jobs
I absolutely adore doing commercial work. On these jobs, we have the chance to set the tone for whatever personality you want to exude. I have been lucky enough to delve into the world of television sets, non-for-profits, restaurants, salons and I dream of one day designing a boutique hotel!
KC Live television set
KC Live television set
RMHC Wylie House
This truly was a house made out of love!!! I feel so lucky to have gotten to be a part of this project that was 15 months in the making and 21,000 sq feet. And it really was a collaboration of the greatest people!
This project included the work of Chris Duh (creative genius extraordinaire), HMN architects and their lovely in-house designer Amy Higgins, Centric Projects, Restoration Emporium, countless others and the amazing dedication and hard work of RMHKC staff like April Hudson and their selfless volunteers.
Thank you to everyone for all that you did to make this house special for those families who have no other choice but to utilize such a needed service.
befores & afters
MLS, Sporting KC & Ronald McDonald House
We had TEN days to pull off a make-over for the MLS "Worx" and Sporting KC's "Victory Project" in honor of the League Cup.
My mother has a sculpture in the Reagan Presidential Gallery. My father is Director of the Albrecht-Kemper Museum of Art. Let's just say it was a natural fit that I would be creative. :)
Plus I found that having original art was a luxury that a lot of people skipped out on in their home design. I would like to change that by having varying price points of AMAZiNG works of art.
My artwork is my way of having fun with paint. I paint beautiful layers of colors that would be the perfect "piece de resistance" in any home and I paint a world of the perfect layers of colors, beautiful snobby clothes and exotic locations.
I am obsessed with the world of fashion and my influences vary from Tom Ford to Henri Matisse to Fairfield Porter.
Wowzahs, what a journey it has been! My life has been full of adventures and I honestly can say I appreciate every moment and bizarre twist and turn! Most people know me from HGTV's show Design Star. Eight thousand people tried out for the show, thirty-eight were flown to Los Angeles for casting, nine people made it to the show and after 5 million viewers, I was lucky enough to win season three.
HGTV Design Star Episode Recap 307
HGTV: Tracee, Jennifer & Scottie
Food for the Soul
New Colors for Living-HGTV
I have been hired to speak at an amazing roster of events ranging from Hallmark's Color Week to International Design Guild's Summit in Las Vegas to Roth Distributing's Design event in Denver to emceeing events like DiFFA's Dining By Design. Please see Q&A page for more information regarding fees.
Hallmark World Headquarters Color week 2011 Used to inspire artists; Scott Butterfield, Trend Consultant for Hallmark Cards:
“Jennifer Bertrand enchanted our artists, designers and writers with her message. She was engaging, expressive and funny but I think her authenticity is what really held the audience of over 250 people, for over an hour.
Hallmark is all about connecting emotionally; she shared with us her elation, her disappointments, challenges and triumphs. Jennifer was the perfect expert to include in our Color Week presentations, a week of inspiring stories that celebrate style, color and design.
We were treated to Jennifer’s talents as a designer and colorist – obviously an authority – but her flair for creative delivery is what most impressed and delighted us. I can highly recommend Jennifer as a speaker with a captivating story.”
design tips video blogs
Painting a Tile Backsplash-HGTV
The Benefits Of Wool Area Rugs with Jennifer Bertrand
Carpeting Design Advice with Jennifer Bertrand
Brass is back? Let's talk design trends w/ HGTV Design Star Jennifer Bertrand

domain: artistic


Rishi Wadhera, MD (Cardiology, BIDMC) noted how hospital visits for heart attacks and other cardiac conditions declined markedly during the pandemic, fueling physicians’ concerns that people with acute conditions may be staying at home due to fear of exposure to COVID-19.
Medical News Today – January 19, 2021
First wave of COVID-19 linked to spike in cardiovascular deaths
About one-third of the 225,530 “excess deaths” in the U.S. during the first months of the pandemic were not directly due to COVID-19, according to a recent study.
Despite this additional death toll, other research showed that the number of people admitted to the hospital with cardiovascular conditions fell sharply in March 2020, coinciding with the rise in COVID-19 cases.
“Hospital visits for heart attacks and other cardiac conditions declined markedly during the pandemic, fueling physicians’ concerns that people with acute conditions may be staying at home due to fear of exposure to COVID-19,” says Dr. Rishi K. Wadhera, a cardiologist at the Beth Israel Deaconess Medical Center (BIDMC) in Boston, MA.
New research adds to these concerns. According to the study, which Dr. Wadhera led, cardiovascular deaths unrelated to COVID-19 increased in New York State, New Jersey, Michigan, and Illinois during the first wave of the pandemic relative to cardiovascular deaths in the same period of 2019.
In New York City, which the first wave hit particularly hard, deaths from ischemic heart disease (which results from narrowed cardiac arteries) increased by 139%, and deaths from hypertensive disease (due to high blood pressure) increased by 164%.
“These data are particularly relevant today, as we find ourselves in the midst of a surge in COVID-19 cases that looks to be exceeding what we experienced last spring,” says senior author Robert Yeh, director of the Smith Center for Outcomes Research at BIDMC.
“Ensuring that patients with cardiovascular disease continue to receive necessary care during our public health response to the pandemic will be of paramount importance,” he adds.
The analysis appears in the Journal of the American College of Cardiology.
The researchers drew on data from the National Center for Health Statistics to compare cardiovascular death rates at the start of the pandemic (from March 18, 2020, to June 2, 2020) with those during the preceding 11 weeks.
To account for seasonal trends, they then compared this figure with the change in cardiovascular death rates over the same period in 2019.
Overall, the rate of deaths due to ischemic heart disease increased by 11% over this period in 2020 compared with the previous year. The rate of deaths resulting from hypertensive disease increased by 17%.
There was no increase in death rates from heart failure, cerebrovascular disease (such as strokes), or other circulatory diseases.
The surge in cardiac death rates was concentrated in New York State, New Jersey, Michigan, and Illinois, which were among the states most affected by COVID-19 during the first wave of the pandemic.
One exception was Massachusetts, which did not see increases in cardiac death rates, despite being an epicenter of COVID-19 cases.
The researchers speculate that people who experienced acute cardiac symptoms may have avoided medical care because they were worried about contracting the virus in the hospital. As a result, more people died at home without receiving the necessary treatment.
The study authors note that the incidence of cardiac arrests in the community has increased during the pandemic.
One study suggests that slower emergency service response times and an increased reluctance among bystanders to perform CPR contributed to reduced survival rates after cardiac arrest.
The authors of the current study list several factors relating to the healthcare system that may have contributed to the surge in cardiac deaths, including:
- canceled outpatient visits, resulting in delayed prescriptions and diagnostic tests
- delayed cardiac procedures
- suboptimal inpatient care due to the increased burden on resources as a result of the pandemic
Increased stress levels among patients in the midst of the crisis may also have played an important role, they write.
The authors conclude:
“As COVID-19 cases surge in different regions of the U.S., public health officials and policymakers should improve public health messaging to encourage patients with acute conditions to seek medical care and expand healthcare system resources to mitigate the indirect effects of the pandemic.”
They note that their study was based on provisional data from the Centers for Disease Control and Prevention (CDC), which may have been incomplete due to reporting delays.
In addition, some deaths may have been misclassified as cardiovascular deaths when COVID-19 was the actual underlying cause. To support this statement, the authors cite research suggesting that some patients with COVID-19 develop cardiac complications.


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Four years of hard work has paid off for New York and New Jersey airport workers.
The American Federation of Teachers took their work over the border when workers at a hospital in Vancouver voted to join them.
A collaboration between the United Federation of Teachers, the New York State Education Department and the New York City Department of Education, bears fruit in the Bronx.
United Steelworkers Local 1999 President Chuck Jones found fellow union leaders and members defending him after being publicly criticized by President-elect Donald Trump.
In a landslide, Columbia research and teaching assistants voted 1,602 to 623 in favor of joining the Graduate Workers of Columbia-United Auto Workers Union. Columbia’s graduate workers are the first in the country to form their union after the National ...
Working people in New York City face yet another MTA fare hike next year—and this time it could go up to $3 per ride.
A group of clergy and immigrant justice advocates have called for President Barack Obama to pardon undocumented immigrants with nonviolent, low-level offenses.
Corrections officers are mourning the death of one of their own after she was ambushed, shot and killed while sitting in her car in Brooklyn this Sunday.
Because of the politics of the current president-elect, states and cities would have to lead the charge on workers’ rights.
One month after Election Day, many of us are still fighting through our shock and grief while trying to better understand the reasons for Hillary Clinton’s defeat.
Pundits on both sides of the aisle may have criticized his approach to governing the city, but a few unions are still backing Bill de Blasio for re-election.
This Monday, members of the Fight for $15 announced a nationwide work stoppage Nov. 29. Workers around the country want to signal to the incoming Donald Trump administration that they’ll keep fighting for a living wage no matter who is ...
In an effort to close the wage gap for minorities and women in New York City, Mayor Bill de Blasio signed an executive order Nov. 4 banning government agencies from asking job applicants about previous salaries.
What some people considered unthinkable happened. Donald Trump’s the new president-elect.
Black Lives Matter is one of the most important civil rights movements in recent years. And it is one we in organized labor must embrace, not only because it is morally right but also because fighting for justice is what ...

domain: news


Designers and manufacturers of innovative motion systems for training, industry & entertainment
Using motion simulation in vehicle training produces a fully immersive and realistic learning environment. Whether the vehicle is on land, water, or in the air, we aim to replicate the motion and surroundings so that operators, and even passengers, can learn their skill safely and efficiently.
Motion systems play a key role in many industries. We understand the need for efficiency and longevity in motion components and actuators used in industrial machinery, construction & agricultural equipment, medical equipment, and automated process systems.
Motion simulators provide a truly memorable experience in VR Arcades and other location based entertainment venues. We can provide off the shelf and bespoke solutions, including games software, to give your VR Arcade an edge.
Built to last
We use innovative engineering design and the best quality components & in-house manufacturing processes to produce systems that are efficient and elegant, yet able to withstand years of punishment.
Off the shelf
We also offer off the shelf components to enable you to build your own motion system.


Posts tagged IEEE
Next, they designed an abuse-evading algorithm to help the robot avoid situations where tiny humans might gang up on it. Literally tiny humans: the robot is programmed to run away from people who are below a certain height and escape in the direction of taller people. When it encounters a human, the system calculates the probability of abuse based on interaction time, pedestrian density, and the presence of people above or below 1.4 meters (4 feet 6 inches) in height. If the robot is statistically in danger, it changes its course towards a more crowded area or a taller person. This ensures that an adult is there to intervene when one of the little brats decides to pound the robot’s head with a bottle (which only happened a couple times).
The publishers Springer and IEEE are removing more than 120 papers from their subscription services after a French researcher discovered that the works were computer-generated nonsense. Over the past two years, computer scientist Cyril Labbé of Joseph Fourier University in Grenoble, France, has catalogued computer-generated papers that made it into more than 30 published conference proceedings between 2008 and 2013. Sixteen appeared in publications by Springer, which is headquartered in Heidelberg, Germany, and more than 100 were published by the Institute of Electrical and Electronic Engineers (IEEE), based in New York. Both publishers, which were privately informed by Labbé, say that they are now removing the papers. Among the works were, for example, a paper published as a proceeding from the 2013 International Conference on Quality, Reliability, Risk, Maintenance, and Safety Engineering, held in Chengdu, China. (The conference website says that all manuscripts are “reviewed for merits and contents”.) The authors of the paper, entitled ‘TIC: a methodology for the construction of e-commerce’, write in the abstract that they “concentrate our efforts on disproving that spreadsheets can be made knowledge-based, empathic, and compact”. (Nature News has attempted to contact the conference organizers and named authors of the paper but received no reply; however at least some of the names belong to real people. The IEEE has now removed the paper).


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BZZZ BZZZ BZZZ The alarm began to peal.
Kaylee woke up to the sound of an Alarm. She shifted on the lights in her room and opened the blinds. As she was scrutinizing the clock, she saw she has woken up earlier. When she fixed the alarm last night, she forgot that tomorrow was the weekend. Kaylee thought of going to sleep likewise, but she didn feel like sleeping because she was assuming about going to encounter Gabriel today and she have to go for photo shoots. She took her phone and checked the time to go for photo shoots. She saw she have just 1 hour to go for it.
She got out of bed, took a shower, and was ready to go to the photo shoot.
After 30 minutes she was ready to go for the photo shoot. She waited for the driver. Seeing the driver coming, she told her assistant to bring her bags and she got into the car.
She had just finished five photo shoots, Attended a fashion show, done an interview, and now her exhausted body was about to have some pampering in the fanciest hotel, All by her.
Suddenly, she heard a loud bang in her room. She went to go and check what it was, and she was shocked to see one of her luggage bags moving. Kaylee slowly opened it and a creepy stranger suddenly sprang out from it, while sniffing her favorite dress.
Her bodyguards rushed as she screamed in horror.
”This is a serious invasion of my privacy. Take him away right now ” Kaylee screamed.
”Kaylee, Im begging you, just one kiss and a selfie. Im your number one fan! ” He started to beg and cry.
”Oh! Please. Can I ever get a freaking break? ” Kaylee sounded.
The hotel incident was circulating on the news in no time. And as soon as she reached her parents, they immediately fired her bodyguards.
She forced her manager to clear her schedule for a week so she could just breathe. But the universe said NO.
While she was doing yoga in her room, someone suddenly barged in. It was her friend, Raco. He was the son of an A-List Actor, and he seemed pretty cool not to mention, Really, Really, Hot.
”Raco, what are you doing here? ” She questioned.
”Its been eight minutes since my last chat. Why aren you replying? ” She questioned back.
”You came here all the way just for that? ” Kaylee shocked.
”NO, I came to do this ” He bent his knees and asked her while offering her a ring ”Will you marry me? ”
”What the freaking craps?! Are you crazy? Wed been friends for like five days. ” She felt furious and refused him because she already loved Gabriel.
”You made me believe you loved me, ” Raco replied.
Suddenly, He started to bawl like a baby on the floor.
”Oh! My God, My heart, It hurts so badly! ” He started to perform.
”I love you, Kaylee. I won leave until you say YES ” He conveyed.
He meant it. And Kaylee had to have him thrown out by security.
After all the crazy incidents with the paparazzi and her fans, Raco was the last straw, and shed finally had enough. She was tired of being worshiped and followed because she was a famous model.
One day she was talking to her friend, she gave her the idea to do plastic surgery to change her identity. She felt it would be amazing to just disappear and return as a completely different person.
She tried on a black wig with bangs to cover her eyes, changed her eye color from black to green, threw in some makeup and baggy clothes, and she couldn even recognize herself.
Suddenly, mom screamed upon seeing her and almost reported her as a trespasser.
She told her mom and dad about her plan of giving up her career and identity for a while, and her dad told her she was crazy.
”No dad Im not. I just want to be a normal girl living a normal life, with no bodyguards and obsessed fans around me. I want to live somewhere else that no one knows about. Ive been home-schooled all my life, and now I want to go to an actual school and have friends. Please let me have this, Im begging you. ”Kaylee tried to explain.
They were speechless for a whole minute.
”Do as you please, sweetheart. Take a break for as long as you want. You deserve it. ” Her mom said while hugging her.
”Fine, But on one condition: Ill choose the apartment for you and you have to take at least two maids with you ” Dad replied and Kaylee agreed with her dad.
And just like that, she was off to a new chapter in her life as the cool and mysterious Siri.
As she was walking toward the school building on Monday, she suddenly stopped upon seeing a familiar dog in the middle of the road. And when she started to pet him, he chased her. Suddenly, a skateboard came flying into the air, scaring it away.
She turned to her savior and Kaylee go shocked. It was Gabriel. Kaylee thought to test him. ”Hey there, Thanks for saving my life, ” She said without looking at him.
”What? I was just doing a back flip and my skateboard slippered ” He replied.
”You still saved my life. Whats your name? ” She requested with looking into his eyes.
”You are not my type sweet cakes, so move on ” He answered.
She felt so different when finally got into the school building without her friends.
After some time, she felt everyone was looking at her like she was wearing something disgusting. She questioned herself is it because of her oversized hoodie? But she had to look as different as I possibly could for my original self
When finally she got into her class, no one even glanced at her. For the first time, she felt invisible.
She headed to an empty seat, but before she could finally sit, her classmate put gum on it.
”I don sit with losers ” The classmate sounded.
”Me, a loser, Ha? ” Kaylee asked.
Just then, Gabriel came in. ”Hi, do you remember me? We met earlier today ” Kaylee asked in a friendly way.
”Are you stalking me? Just give it up sweet cakes ” Gabriel said.
Kaylee got furious with his manners and said ”I was already here and my name isn sweet cakes, its Siri ”
”So, you are like real-life Siri, the iPhone virtual assistant? ” Gabriel asked while laughing.
Then they all started to make fun of her fake name and ask her lots of silly questions. She felt it was so annoying.
She put her headphones on, but Gabriel took them off.
”Why aren you replying to our questions? Are you glitching or something? ” Gabriel questioned.
Kaylee got angry. ”Haven you heard of the last Apple update? Siri won answer stupid questions from now on ” Kaylee argued.
”I didn know Siri was feisty, ” Gabriel said in a joyful mood.
Just then, a familiar girl entered and her eyes went straight to Kaylee. She voiced ”OMG, What a terrible day to have eyes! That outfit is horrible. Someone take this new girl out of this room right now ”
”Stop acting like you
e the fashion queen, Peyton. Remember how you got rejected for a commercial and never made it as a model? And your tantrum video went viral? ” Gabriel laughed.
”Those people were just blind. I couldn believe they chose that trash Kaylee over me. She stole my place. ” Payton replied.
”Kaylee is not trash. Kaylee is a goddess ” Gabriel argued.
As Kaylee was listening to that she felt her heart beating very fast and she felt so loved when Gabriel said pleasing about her.
Kaylee thought to know what Gabriel thinking about her and she asked ”Sorry to butt in, but are you guys talking about the supermodel? ”
”Yes, the worst supermodel of all time ” Payton replied.
At that time Kaylee remembered Payton. She auditioned with Kaylee for the commercial that launched her career, and she has thrown a huge tantrum when she wasn selected, And Gabriel had a crush on her.
But she had a fit of huge anger because of his jokes.
Ultimately, when school is over, she went home. The time came to go and meet Gabriel as real Kaylee. As Kaylee was thinking about his jokes, she felt furious and decided not to go and meet him. But she wanted to meet him and now she doesn want to meet him because she knew Gabriel had a crush on her. She send a message to Gabriel that she cannot come and meet him as she was very busy. As he was sending her lots of messages and trying to talk, she just ignored him and didn reply to him. Gabriel started to think did he did something wrong to her because she was ignoring him and she didn even come to school today but She asked him to come and meet her today. Gabriel felt so worried and he waited until she send a message to him.
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domain: literature


German authorities announced on Tuesday that when the copyright to Adolf Hilter’s notorious Mein Kampf expires in three years’ time, an ‘annotated’ version will be made available to students across the country.
The state of Bavaria, which became the beneficiary of Hitler’s works, property and money following the dictator’s suicide in 1945, said it was important for Germany to publish versions for children with expert analysis and comments from historians that refute his ideology.
"We want to make clear what nonsense is in there, however with catastrophic consequences," announced Bavaria’s finance minister Markus Soeder in Nuremberg. “We will demystify this work.”
The book is not illegal in Germany, but the state has not allowed it to be printed amid fears that it could promote Nazism.
While other countries have printed foreign-language editions of the work, upon which the Nazi’s genocidal policies were based, Germany has been unable to get a newly-printed version in their own language for 67 years.
Now, however, Bavaria has given permission for the rest of Germany to freely print and distribute it and in 2016, third parties will be able to release copies without obtaining permission from the state "unless it is used to incite racial hatred," Soeder said.
Recently, Bavaria won a court battle against a British publisher who sought to publish parts of the anti-Semitic diatribe in magazine format.
Bavaria contends that due to the widely available information on the Internet as well as numerous pirated copies of the work published abroad, it is better to have some control over the work when the state loses its copyright than none at all.


text:
It's generally best to correct dental and orthodontic issues when they're first noticed, but life doesn't always work that way. You might find yourself in a position where you need to correct several issues simultaneously, provided that the required forms of treatment are compatible. If you have deteriorated teeth, is it better to have these repaired (or removed) before or after straightening your teeth with Invisalign?
If your orthodontist tells you that you qualify for Invisalign, you might breathe a sigh of relief. You won't need traditional metal braces stuck to your teeth, nor will you need the constant orthodontic adjustments that these braces demand. Instead, you'll have a series of transparent aligners (which look like retainers or ultra-thin mouthguards) made that you'll wear for approximately 22 hours per day, for one to two weeks. Each tray fractionally repositions your teeth, and by the time your treatment is over, your teeth have been straightened to the predetermined level.
Not in the Best Health
What happens when some of those teeth aren't in the best health? This is something that must be addressed before your Invisalign treatment begins, otherwise, your orthodontic treatment will be disrupted. Because each aligner tray is customized and designed to tightly hug the exact contours of each tooth in your mouth, those contours need to be finalized before your aligner trays can be manufactured. Dental restorations, whether this is a simple filling to patch surface decay or a dental crown that fits over the entire tooth, a restoration changes the shape of the tooth.
You'll be directed to have these irregularities fixed before beginning Invisalign. Your trays can then be made to accommodate the repaired teeth and any restorations bonded to them. These treated teeth can still be repositioned and will be straightened along with the rest of your teeth. As long as the teeth have an intact natural root system, they can be orthodontically aligned.
Some permanent teeth replacement options use an artificial tooth root system, which is basically what a dental implant is. Once implanted in your jawbone, the device (a small titanium screw) becomes a tooth root that can hold a natural-looking porcelain tooth. However, once placed, an implant's location is fixed and immovable. It cannot be orthodontically aligned with Invisalign (or any teeth straightening treatment).
If it's intended that one (or more) of your teeth must be extracted and replaced with an implant, the extraction will take place prior to your Invisalign treatment. The implant can be fitted once your teeth have been straightened. For cosmetic purposes, an orthodontist can add a pontic (single false tooth) to your aligner trays, concealing the extracted tooth (if it's obvious).
Invisalign is compatible with many dental treatments—but some treatments must occur before Invisalign, and some must be delayed. Contact a local dentist to learn more about Invisalign.Share


text: The Regina Alternative Measures Program (RAMP) hosted a Training and Restorative Justice Conference. This three day conference was held in Saskatoon, Saskatchewan on March 12th,13th and 14th, 2008. The main objective of this conference was to provide restorative justice training for the RAMP's staff and Justice representatives of First Nations and Métis communities across Saskatchewan. The training focused on sharing best practices to develop and strengthen community based involvement. The outcomes from this project will include improved community capacity to deal with justice issues, improved service delivery, community awareness and participation and in the longer term, reduced victimization, crime and incarceration in communities operating a community justice program.

domain: sociology


text:
- More details have been revealed about Florence Henderson's death - TMZ
- Jimmy Kimmel is hosting the Oscars! - Gossip Cop
- Camila Cabello looks unrecognizable in a blonde wig - Just Jared Jr
- Get all the behind-the-scenes details from the Victoria's Secret Fashion Show - Radar
- Mariah Carey had a busy weekend! - Lainey Gossip
- Lebron James won't stay at Trump Hotel - The Hollywood Reporter
Rosie Huntington-Whiteley: Rihanna Concert Night Out!
About Photo #2846074: Rosie Huntington-Whiteley steps out in style while heading to Rihanna's Diamonds World Tour at the Staples Center on Monday (April 8) in Los Angeles. "So close… Read More Here

domain: celebrity


SanDisk Corporation, the worldwide leader in flash storage cards, has launched the fastest 32-gigabyte (GB) SDHC card in the marketplace. The 32GB SanDisk Extreme SDHC card with as much as Thirty megabytes per second (MB/s) read and also write speeds offers industry-leading efficiency along with substantial storage capacity, aiding digital photography lovers make use of the superior options that come with the present DSLR video cameras.
"The market for entry to mid-level DSLR cameras is growing, and SDHC is becoming the de-facto card format for these devices," said Susan Park, director, retail product marketing, SanDisk. "Our card's 32GB of storage and up to 30MB/s read & write speeds enable DSLR users to shoot without worrying about storage or speed limitations. SanDisk Extreme SDHC cards provide consumers with a more enjoyable user experience, letting them focus on what is really important - the images that they are capturing."
Super fast Write Speed Captures Photos Swiftly
A memory card's write speed plays a significant role within the entire system of the digital camera when taking photos in fast sequence. In the event that your card is unable to process data quickly enough then your burst mode capturing may pause unexpectedly since the card catches up to the camera. Burst mode bottlenecks may lead to missing "the" shot, particularly at sporting as well as other fast-motion activities. The SanDisk Extreme SDHC card provides highest data-transfer rates, offering consumers a memory card quick enough to discover the entire features of their DSLRs.
The 32GB SanDisk Extreme SDHC card adheres to the SD Association's brand new Class 10 standards, which meets requirement designed for modern day high definition (AVCHD) video recording. The card provides a sustained write speed quick enough to guarantee high-definition video recording and potential effective at storing 160 minutes of full High definition 1920x1080 pixels at 24Mb/s data transfer rate.
Large Data files Demand Large Storage
Recently-released DSLR camera models such as the Nikon D90 as well as D5000 provide customers a chance to record High definition videos, making large files which could fill lesser-capacity cards quickly. The present high-megapixel DSLRs can also produce significant still pictures like those produced from the RAW format employed by professional photographers who desire to take advantage of the improved display quality as well as overall flexibility which RAW permits during post production.
RAW images need up to ten times the maximum amount of storage space as normal JPEG pictures, and when taken in quick sequence during burst mode can quickly fill small storage cards. The 32GB SanDisk Extreme SDHC card may save as much as 2500 RAW[3|] pictures, providing photographers with peace of mind along with assurance that they're not going to run out of space for their photos.
SDHC cards ensure that your device doesn't become bulkier and are much faster and reliable than hard disk based devices.
Well-known for their world-class durability, SanDisk Extreme SDHC cards assure operation at extended temperatures ranging from minus Thirteen F (minus 25 C) to 185 F (85 C). SanDisk Extreme SDHC cards are totally appropriate for any digital camera, card reader or some other device that supports SDHC cards.
09 February 2010 Hardware


text:
The recent violence emanating from different section in the country has come to make us understand certain things that we have ignored for a long time. That is the fact that we are always preaching and asking for togetherness but in the real sense we do not want it. It is very vital that we as a people, must come together to accept the fact that in our differences lies our strength.
The fulani tribe has lived with us for many years if not from the inception and creation of this great nation, Nigeria. They are known for their nomadic lifestyle. Even in the days of our forefathers, the fulani were a part of our society. Mostly of the states in Nigeria has a place where fulani were given as a place of residence. Most of these place were named or called Sabon-Gari and some other places either Angwa or hausa community.
Over the years we have been able to live peaceful as there were intermediaries between the fulanis and their host community whenever there was a problem.
In recent times, dissatisfaction coming from various angles has fueled the violence which in most cases are instigation from the bad eggs in the society.
The fulani just like everyone has both the good and the bad ones. A complete tribe can not be evil. We must learn to understand the dynamic nature of humanity, that all can not be good just as all can not be bad.
The fulani tribe has contrbuted to a lot of socio-economic and cultural development in Nigeria. In Nigeria they are regarded as the fourth largest tribe in population. It would be wrong to say they are outcast in their own nation.
Everyday, we are advocating for the removal of state of origin and we do not want the fulani to live with us. We must wake up from this sleep. For the country to move forward, we must learn to coexist with one another without any bigotry.
Nigeria is for all tribes. No single tribe has the monopoly of it's ownership. God bless the federal republic of Nigeria.
Content created and supplied by: tofaashir (via Opera News )


text:
Pozzo della Chiana, Tuscany
Located high on the hills of Valdichiana and surrounded by the estate’s very own vineyards, positioned between Arezzo, Cortona and Siena.
Arrival day: Saturday Car hire: Recommended
Fattoria Santa Vittoria is located high on the hills of Valdichiana and surrounded by the estate’s very own vineyards – a perfect setting that enables you to visit the nearby town of Pozzo della Chiana and also taste some of the delicious, award-winning wine produced here at Santa Vittoria. The 18th Century farmhouse has been beautifully converted by the local Niccolai family who will ensure that you have a wonderful stay in this stunning part of Tuscany.
The old farmhouse has been transformed into 5 very comfortable apartments which are located in the middle of the vineyards – the location could truly not be bettered! All of the original character has been kept and the apartments are furnished in a pretty country style in keeping with the period of the building. Each apartment has a separate area in the grounds with lawns that sweep down the hillside towards the inviting pool area. There are vines as far as the eye can see laid out in beautiful rows and can do nothing but tempt you to try the wine.
Located on the ground floor, the entrance takes you directly in to a lovely, bright lounge/dining area (with sofa bed), along with a small kitchenette, one double bedroom and a shower room.
A ground floor apartment with entry into the lounge/dining area (with sofa bed). There is a small kitchenette with one double bedroom and a shower room.
A ground floor apartment with entry into the lounge/dining room (with sofa bed). A couple of steps lead to a fully equipped kitchen with oven. There is one twin room, a shower room, which is adapted for disabled use, and one double bedroom with an en-suite shower room.
Stone steps lead up the outside of the building to this first-floor apartment. Entry takes you into the open plan lounge/dining area with television and there is a fully equipped kitchen with oven and dishwasher. There are three twin/double bedrooms, one with en-suite shower room and a further shared bathroom with bathtub.
A ground floor apartment at the rear of the building and offers a little more privacy than the other apartments. Entry is into the lounge/dining area (with double sofa bed) and there is a small kitchenette with an oven plus one twin/double bedroom with en-suite shower room and second twin/double with a separate shower room.
There is a super communal area which is home to a great library and huge dining table which is accessed from the front of the farmhouse along with a fully equipped kitchen for the use of guests. This is perfect if you are part of a group of family and friends and want to eat together inside.
Dinner is available upon request and is served in a beautiful dining area at the rear of the farmhouse. The Niccolai family are always happy to offer wine tastings to couples and groups alike – with such an acclaimed name, we suggest that you do not miss out on trying some of super wines made on the estate.
Ivy-clad walls, sunflowers, rolling hills, olive and wine groves plus brilliant blue skies all add to the fabulous Tuscan experience here at Fattoria Santa Vittoria.
Please email or phone +44 1223 460100 for prices.
Security deposit: €150
Heating for Gazza and Istice €10 per day
Heating for Lepre, Upupa and Pagliericcio €15 per day
Breakfast (to be reserved at least one week prior to arrival) basic buffet €11 per person, extra €16 / person
Dinner (also to be reserved at least 1 week prior to arrival and depending on our availability) €45 / person for adults and €25 for kids from 4 to 12
Please email or phone +44 1223 460100 for availability.
Rachel Humphries, Chester
Beautifully clean – gorgeous bedding and towels. Beautifully decorated and maintained. Perfect location for sightseeing, near to good facilities. Beautiful Location on a vineyard. Fabulous holiday.
Euan Martin, Banff
We had a so had a wonderful holiday in a great location. Marta and Mauro, supported by their excellent staff, were superb hosts who went the extra mile/kilometre to make us feel welcome. My family enjoyed the company of the resident cats. The area suited us perfectly as it felt like the ‘real’ Italy and not a tourist trap.
Kristin Byng Nelson, UK
Lovely place and hosts. Relaxed and informative. Would not hesitate to recommend or to go again!
Sally & Geoffrey Ragdale, Crewe
Great location with stunning views. Owner and staff couldn't have been friendlier. Although the appartments facilities were rather dated didn' t detract from a wonderful week.
Kirsten Cole, Bracknell
Excellent – remote and a distinct lack of WiFi!! We had a brilliant trip – staff at Essential Italy were helpful & Marta and her team made us so welcome they were friendly and helpful. Would recommend this.
Maria Collett-Bevan, Guernsey
Our apartment was tidy, well equipped and had everything we needed to enjoy our stay. Our host, Marta, also gifted some wine and lovely homemade jams. Great location. Easy driving distance to Montepulciano, Florence and Siena. We thoroughly enjoyed our stay at Fattoria Santa Vittoria and found the booking process very easy. We would absolutely use Essential Italy again.
Tina Lucas, Cowes
We travelled in March and the apartment was lovely and warm on arrival... bottle of wine and a homemade jam on the table and the owner to greet us. Brilliant. The beds very comfy, good linen and towels too. Marta made us feel very welcome and was very informative and interesting. We really appreciated the personal touches and the information that I was given by Helen. It is obvious that you know your accommodations! A very professional service.

domain: geography


text:
During these sessions, clients generally remain clothed and may experience physical or emotional release. Our therapists may use some of these modalities during your massage session at no additional charge.
*Please call for further information and appointment.
This signature modality is a self-help tool to balance body, mind, and spirit by releasing blocked energy in the body's cell memory and rewiring the energy patterns of the chakras and brain. Tapping with the fingertips on specific meridian endpoints of the body while focusing on challenging or perplexing emotions or physical sensations has proven to remove or resolve a wide range of issues effectively. These include stress, anxiety, PTSD, phobias, emotional disorders, chronic pain, addiction, weight control, and limiting beliefs. Clients wear comortable clothing. Initial session is 75-90 minutes. Additional 60- minute sessions can be booked.

domain: psychology