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ASX Junior’s Flagship Immunomodulatory Drug Could Turn the Tide in Duchenne Muscular Dystrophy Treatment
PUBLISHED: 16-10-2018 10:05 a.m.
12 minute read
Duchenne muscular dystrophy (DMD) is a rare, yet fatal, muscular genetic condition that affects one in 3600 to 6000 male births worldwide.
With first symptoms emerging at between three and six years of age, the condition causes muscle weakness and atrophy, starting with the pelvic area and shoulder muscles and progresses to affect the trunk, forearms and other muscles. Few patients survive past 30, eventually succumbing to breathing or heart problems.
Only recently have therapies emerged to help males with DMD survive beyond their teen years and with advances in cardiac and respiratory care, survival into the early 30s is becoming more common.
Yet treatment options for the disease remain limited and, sadly, there is no cure.
Today’s ASX biotech junior has its hands on an antisense drug candidate developed by world leaders in antisense drug development and commercialisation, the US$6 billion-capped Ionis Pharmaceuticals (NASDAQ:IONS) that it hopes could have a significant impact on the future treatment of this devastating disease.
This Australian company is one of only a few companies working in the DMD space with one drug dedicated to the largely unmet need in treating the inflammation associated with the disease. Also working in the company’s favour, is the growing activity in this arena which looks to be attracting major investment. According to GlobalData, in 2017 $2.2 billion was issued in capital raising deals involving DMD pipeline drugs.
GlobalData’s expectation is that high value capital raisings to support DMD drug development will continue into 2019, with big strategic alliance deals to follow for DMD drugs. This augurs well for today’s company as it keeps one eye on attracting interest from big pharma in its own DMD drug.
So why is antisense technology such a hot area?
Antisense technologies prevent the production of proteins involved in disease processes — in order to provide a therapeutic benefit. Proteins are fundamental components of all living cells and include molecules such as enzymes, hormones and antibodies, necessary for carrying out the body’s functions. The overproduction or abnormal production of proteins is associated with many diseases. Antisense prevents undesirable protein production in disease.
The drug candidate being studied by today’s company is actually targeted at a protein believed to be involved in causing the muscle inflammation that exacerbates the muscle fibre damage in DMD patients.
This ASX junior, capped at just $7 million, is already in a Phase II clinical trial with its flagship drug to treat DMD, and in August it reported that the first patient in the trial had been dosed.
The six-month dosing trial of immunomodulatory therapy, ATL1102, in nine non-ambulant DMD patients aged 10-18 years is now underway at the neuromuscular centre of the Royal Children’s Hospital in Melbourne — the largest clinic in the southern hemisphere treating children with DMD.
The ATL1102 drug inhibits the expression of protein ‘CD49d’ on certain immune cells (T cells). DMD is more severe and progresses more rapidly in patients who have more T cells with high levels of CD49d.
ATL1102 is being developed to treat the inflammation that exacerbates tissue damage and causes fibrosis in DMD patients — a condition that, at the moment, can only be managed with corticosteroids.
The problem is that corticosteroids come with a host of serious side effects, particularly when used for long periods as is required for DMD patients. They are also known to be less effective in patients with high-CD49d T cells.
With a drug that could prove to be a viable alternative to corticosteroid treatment, it comes as little surprise that the company attracted the attention of major institutional investors.
Two fund managers, $2.9 billion-capped Platinum Asset Management (ASX:PTM) and Australian Ethical Investment (ASX:AEF), were the major investors in a $5 million raising with the capital to be put towards the company’s now underway Phase II DMD clinical trial. Both groups bring a lot of credibility to the table... and no doubt conducted robust due diligence before deciding to back this micro-cap biotech.
Importantly, as DMD is considered an ‘orphan disease’ the company expects to benefit from the development and IP incentives provided to companies to develop orphan drugs, including the offset of drug development costs and help with getting the drug out to market once it’s passed muster...
Several countries have public policy around orphan drugs to ensure that treatments are developed even though a condition is rare and doesn’t have the market of more common ailments such as diabetes, asthma or cancers. Orphan drug status is assigned to treatments that might otherwise lack sufficient financial incentives or lack the commercial market needed to attract R&D investment.
With plenty to delve into, it’s time to formally introduce Next Biotech readers to:
ASX biopharmaceutical company, Antisense Therapeutics (ASX:ANP), is seeking to develop new and highly effective therapeutics for disease where there is a significant unmet medical need.
The company has two drug candidates, ATL1102 and ATL1103, which it has been studying in clinical trials for use in three diseases: Duchenne Muscular Dystrophy (DMD), Multiple Sclerosis (MS) (ATL1102) and acromegaly (ATL1103).
While it’s made serious headway in using ATL1102 in MS and ATL1103 in acromegaly, ANPs main clinical development focus right now is candidate ATL1102’s potential to become a therapy for DMD.
DMD is a rare genetic disorder caused by mutations that disrupt the normal function of a gene on the X chromosome. It is a devastating genetic muscular disease caused by loss of the protein dystrophin with progressive muscle wasting and associated muscle injury leading to inflammation and fibrosis, tragically resulting in a 100% mortality rate.
The illustration below highlights the devastation it can cause:
Unfortunately, despite there being no known cure, the disease doesn’t get the same attention as more widely recognised diseases.
However, the space is seeing plenty of recent activity as improved treatments are sought and the market is awakening to the enormous value being created by active players in this space. Notably ATL1102 may work in tandem with other treatments on the market including the $8.7 billion capped Sarepta Therapeutics' (NASDAQ:SRPT) drug developments in this field.
What stands out, and why it is complementary to other treatments, comes down to the fact that ANP’s treatment is one of only a few that is looking to tackle the inflammation associated with the disease.
ANP is conducting a Phase II clinical trial of ATL1102, a highly active immunomodulatory antisense drug to human CD49d RNA in DMD patients at the Royal Children’s Hospital (RCH) in Melbourne.
Here’s a look at how Antisense works:
This video may also help illustrate how the technology works:
Previously, ANP successfully completed a Phase II efficacy and safety trial of ATL1102 in patients with relapsing-remitting multiple sclerosis (RRMS). After just eight weeks of dosing, ATL1102 demonstrated a 90% reduction in inflammatory MS brain lesions versus placebo.
Given its target’s (CD49d) potential role in DMD disease development and its trial success in MS, scientific researchers have acknowledged the drug’s potential use as a therapy for DMD. The current trial will assess the safety and tolerability of ATL1102, as well as its efficacy in slowing DMD progression by decreasing inflammation mediated tissue damage.
ANP is studying ATL1102 as an agent for the treatment of inflammation that exacerbates muscle fibre damage, for which DMD patients currently have to use corticosteroids.
Steroids have been recommended as a treatment for patients with DMD to preserve or improve muscle strength and motor function for decades.
However, steroid use remains controversial, with researchers and clinicians disagreeing on the optimal dosing regimen used for DMD patients.
When used at high doses and for long periods of time, corticosteroids have a range of serious side effects, and also aren’t as effective in patients with a greater number of white blood cells that express high levels of CD49d receptors (ATL1102's biological target) on their surface.
And now a new study, “The effect of steroid treatment on weight in non-ambulatory males with Duchenne Muscular Dystrophy” published in the American Journal of Medical Genetics, has linked long term steroid treatment to increased weight gain in boys with DMD who are unable to walk. It recognised the safety issues with steroids and highlights the importance of finding new and improved therapies, such as ATL1102, to treat inflammation in boys with DMD.
The findings of that study and ANP’s therapies were reported by Finfeed.com:
ATL1102 now in Phase 2 trials
In July, ANP announced it had begun the Phase II clinical trial for DMD candidate ATL1102 at the Royal Children’s Hospital (RCH) in Melbourne.
The study is being led by the Clinical Investigators Dr Ian Woodcock, a Neuromuscular Fellow at the RCH and Professor Monique Ryan, Director of the Neurology Department at RCH.
ANP’s Phase II trial will primarily assess the safety and tolerability of ATL1102 and also its efficacy in terms of its effects on the blood and imaging markers of inflammation and muscle damage and other important markers of disease progression.
The DMD patients to be enrolled in the trial are all non-ambulant boys (meaning the disease has progressed so far that the boys cannot walk) aged between 10 and 18 years.
Specifically, ANP and the advisory team behind the trials are hoping that ATL1102 can achieve two related things in patients:
- Eliminate a substantial portion of continued muscle degeneration by ameliorating the damaging effects of inflammation.
- As a result of (1.), extend the period of mobility in the boys and in particular upper limb functioning for the trial patients who use a wheelchair.
The treatment being used is the same drug previously used by ANP in successful Phase II trials in MS patients.
ANP announced in late August the dosing of the first patient in the trial — a key inflection point and milestone for the micro-cap biotech stock. (Full details on the trial are available here on the Australian New Zealand Clinical Trials Registry.)
The company hopes to generate positive trial data that would cement itself as a strong contender to help treat a disease that is, desperately underserved.
Then there’s the possibility that if ANP has success with its clinical trials on ATL1102, it could strike a deal with Big Pharma...
ANP has already partnered with world leaders in antisense drug development and commercialisation and the original creators of ATL1102 —the $6 billion capped Ionis Pharmaceuticals (NASDAQ:IONS).
ANP has a worldwide exclusive license from Ionis Pharmaceuticals to their intellectual property on ATL1102 for all disease applications.
ANP has subsequently generated their own IP and patents around the drug, having taken ATL1102 all the way from preclinical studies to the current Phase II clinical trials.
Below is a look at another link between ANP and a multi-billion dollar US biotech.
A look at bigger players in DMD drug development
In late 2016 Sarepta Therapeutics (NASDAQ:SRPT) received FDA approval for eteplirsen, a drug that can help restore the dystrophin protein levels in children with DMD.
Sarepta has only one approved drug, Exondys 51 (eteplirsen), which was specifically designed to treat the 13% of DMD boys who have a specific mutation of the dystrophin gene.
Exondys 51 brought in a cool US$73.5 million in net revenues for the quarter ending June 30 — news that saw the stock surge 19% after the quarterly was published in August. Sarepta’s current market capitalisation is more than US$8 billion.
All up, Sarepta’s market value has gained 380% since it secured FDA approval for its first DMD drug in September 2016.
This is particularly relevant for ANP as former SRPT Chairman, William (Bill) Goolsbee, is a director on ANP’s Board.
Goolsbee is also the Chairman of the company’s scientific advisory board which includes the two Australian scientists (Profs Steve Wilton and Sue Fletcher) who are the inventors of Sarepta’s drug, eteplirsen. Bill has extensive experience and networks in the field of DMD drug development and commercialisation which he is imparting on ANP in their development of ATL1102.
This plays nicely with the fact that, as at 30 June this year, ANP held cash reserves of $4.3 million to see it through the Phase II of its all-important clinical trial for ATL1102 in DMD patients. The company expects to benefit from the R&D tax incentive cash rebate from the ATO related to its R&D expenditure.
Overall there has been a flurry of activity in this space by large pharma companies. Here’s a look at a number of the recently initiated DMD trials: It’s important to note again, that ANP is one of very few company’s looking to tackle the inflammatory component of the disease and as such could anticipate limited competition if its clinical development plans are successful.
Institutional interest boosts the books by $5M
In May, ANP completed a $5 million capital raising, with the backing of two major institutional investors, Australian Ethical Investment (ASX:AEF) (holding a ~19% interest in ANP) and Platinum Asset Management (ASX:PTM) (holding a 5.6% interest).
The $5 million has been earmarked for the ATL1102 Phase II clinical trial in DMD patients and to initiate an Early Access Program in Europe for their drug ATL1103 in acromegaly.
AEF and PTM’s holdings in ANP provide solid proof that the ‘smart money’ is backing this micro-cap.
With cash in the bank and given its track record in completing multiple successful Phase II trials, there is good reason to believe that ANP could successfully deliver positive results on the current Phase II ATL1102 DMD trial now underway ... and to expect significant associated newsflow to begin rolling in shortly.
With all of these positives, it seems only a matter of time before investors will recognise the unique medical and commercial potential of ANP’s therapies.
This information is general financial product advice only and you should consider seeking professional advice before making any investment decision. All indications of performance returns are historical and cannot be relied upon as an indicator for future performance.

domain: news


text:
A Door Closes…Another One Opens
My stomach was in knots, as I continued walking up the beautifully brick path toward a large elegantly engraved wood door. The light from the moon were shining brightly off the huge glass window that adorned the front of the house. The house was absolutely marvelous. It had that wooden ski lodge feeling, but it yet it retained a feeling of home. My heart was beating a thousand miles a minute. I could not wait to surprise her. I stood at the door and rang the bell twice. I began to smile, she had no idea it would be me at the door.
The door opened and I heard the shocked voice of Tiffany’s mother say, “Jake! What in the world are you doing here?” She had a big smile on her face. She quickly smothered me with a hug. Tiffany’s parents love me, especially her mom. I am always good with the moms.
As she stepped back, I replied jokingly, “Hey! I was in the area and I thought I would stop by real quick!”
“Well come in out the cold”, she spoke in a motherly tone.
I stepped and began to explain, “I actually finished up with everything at work and decided I would surprise your sweet daughter with a visit.”
“That’s so sweet of you and it’s great to see you. Everyone thought you had to work. Tiffany is going to be a mess when she sees you”, she proclaimed as she leading me down a hallway.
We ended up in a family room that was the size of my apartment back home. I exchanged greetings with Tiffany’s farther and had to re-explain my surprise plan. We talked for a few minutes about different things, mainly work, and some sports. Then it dawned on me, I had not even seen my girlfriend yet. So I waited for a good break in the conversation and said, “So where is Tiffany by the way?”
Her mom perked up and replied, “Oh, yeah, the reason why you are here, right. Well you actually just missed her. She went out with her friends just about an hour ago. But it’s not a big deal, I will just text her and see where she is at and I won’t mention you are here.”
“Ok, thanks that would be great”, I replied. It was twenty past ten o’clock and I should have guessed that Tiffany along with her friends would be out on the town at this point. But this would not hamper my plan. I would have to surprise her at a different location. Actually this might even make it better.
Sharon, Tiffany’s mother, provided me with the directions to the place she was at, which I typed into my rental car’s GPS. It was only a short drive from their house. A short drive before I would see my beautiful Tiffany. I could not wait. She was such a fun girl who did not take life to serious. It was approaching out two year anniversary. I had recently thought about popping the question to her. But for now that would be on hold. A cross country surprise would suffice. Would she run into my arms screaming? Or maybe she would punch me in the chest with shock? Whatever her reaction was, I knew this was going to be something to talk about for a long time afterwards.
I parallel parked on the street adjacent to the bar Fat Whiskey. It was tucked in among a row of other bars, stores, and other buildings. I walked up to the door and pushed my way through with an air of confidence with feelings of warmth about me. The set up was more like a bar than club, but there were areas where you could dance or sit on lounge furniture. I scanned the bar quickly and saw nothing. I was nervous at this point, so I stopped at the bar for a crown on the rocks with a splash of water. Trust me, it is one good drink.
I continued to look around, when boom! I spotted her two friends Nicole and Whitney seated on colorful couches. They saw me at the same time and their eyes suddenly became big. They were the size of saucers as they stared at me with their mouths open. I looked to Nicole’s left and I saw Tiffany. Well I saw what I could see of her. Suddenly my eyes grew to the size of bowling balls and my jaw hit the floor, as I now began to stare. She was seated on the lap on some guy with her face firmly planted in his, while he was getting a nice feel of her ass. To say they were making out would be an understatement.
I stood there staring at her. Her friends sat there staring at me. I could feel them looking at me, but I did not care at this point. It felt like I was watching her making out with this guy for an eternity. Feelings of anger, hate, sadness, confusion, shock, and mostly anger coursed through my body, pulsating like an electric current. I began to feel sick to my stomach as I continued to gaze. I could not shake the thought of are you fucking serious? Are you fucking kidding me? I said that over and over in my head, as I became angrier with each ass grab and kiss. Finally, her friends snapped out of their trance and nudged Tiffany on her shoulder. Nicole, I can’t stand that bitch said something to her and she spun around. She stood up, fixed her clothes, and proceeded to walk toward me with a look of surprise on her face. Surprise!
Before she could get to me, I walked out the door and started to walk back to my rental car. “Jake! Jake! Stop! Come here”, she yelled at me as I neared my car.
I turned around and saw her boy toy right behind her oddly enough. This should be interesting. “Jake! I am so sorry, this is not what you think!”
She was now a few feet in front of me and her boy toy was about twenty seconds away. “Really? Fucking Really!? Are you fucking serious. I flew all the way out here to surprise you and you are making out with this guy? Get the fuck out of here!”, I yelled, eying this guy as he approached closer.
“Hey babe, who is this guy?” he asked, while slapping and grabbing a handful of her ass from behind.
“Just go away, this…” before she could finish explaining to him that the guy in front of him was in fact her boyfriend of almost two years, I punched him as hard I could in the mouth. He went flying to the ground as if he was a crumpled piece of paper. I quickly shook my hand off and looked at her calmly in the eyes and said, “I have a plane to catch.”
“When one door closes, another opens; but we often look so long and so regretfully upon the closed door that we do not see the one which has opened for us.” -Alexander Graham Bell

domain: literature


text:
In this online workshop the Climate Psychologists will help you and your family to begin to understand how we take in information about climate change and how this can make us feel and behave. We can learn to name and process our emotions. We can also learn to manage our feelings so that they can motivate and inspire us to take climate action. We will learn how to take care of ourselves so that we can take care of the planet. We will think about our values and goals and how we can get to work to help the Earth. We can all make a difference!
This event is linked to the Anaesthesia Museum’s 2021 online
Green: Anaesthesia, Climate and Sustainability, which explores the environmental
impact of anaesthesia and healthcare services.
About the facilitators
Megan Kennedy-Woodard and Dr Patrick Kennedy-Williams are the co-directors of Climate Psychologists, an independent organisation providing individual therapeutic support and wider consultation regarding the mental health implications of climate change. Central to their work is climate change communication. They work with individuals, parents, educators, national government and media organisations to promote psychologically-informed, constructive communication. Their aim is to inspire hope and positive, sustainable action to combat climate change. They are the authors of 'Turn the Tide on Climate Anxiety', due out later this year with Jessica Kingsley Publishing.
This is a recording of a previous event, which will be sent to you after you complete my booking.

domain: psychology


Tropical forests are home to more of the world's terrestrial biodiversity than any other habitat, but are increasingly threatened by the impact of human activities. Illegal logging, in particular, poses a severe and increasing ...
Researchers studying plants, ants, birds, dung beetles and orchid bees in the Brazilian Amazon have found clear evidence that deforestation causes drastic loss of tropical forest biodiversity.
Higher supermarket prices for eco-friendly palm oil products could help save endangered species, according to a new study by North American and U.K. researchers.
A new policy paper led by University of York scientists, in partnership with Proforest, aims to increase awareness among researchers of the High Conservation Value (HCV) approach to safeguarding ecosystems and species.
When it comes to conserving tropical forests and the carbon stored within them in order to prevent climate change, the role of forest animals may be too important to ignore.
While inadequate funding has hampered international efforts to conserve biodiversity in tropical forests, a new Duke University-led study finds that people in a growing number of tropical countries may be willing to shoulder ...
As a spin-off (pun intended) of their Tropical Biodiversity course in Malaysian Borneo, a team of biology students discover a new spider species, build a makeshift taxonomy lab, write a joint publication and send it off to ...
When tropical forests are cleared, they can take a century or more to re-absorb the carbon they once held, according to a new study. But their biodiversity is even slower to recover, and some species may never return.
A new study of re-growing tropical forests has concluded that plant biodiversity takes longer to recover than carbon storage following major disturbances such as clearance for farming.
Teeming with millions of species, tropical coral reefs have been long thought to be the areas of greatest biodiversity for fishes and other marine life—and thus most deserving of resources for conservation.


Poco is gearing up to add a new smartphone to its affordable M series. Already, the global executive has confirmed that they will take the wraps off the Poco M3 Pro 5G at an event later today. Of late, we have been coming across several leaks and teasers that reveal what we can expect from the device. Now, a recent leak has shed light on the pricing and design of the upcoming affordable 5G smartphone.
While we are just hours ahead of the launch of the Poco M3 Pro 5G, the YouTube channel ChinaMobileMag has come up with an unboxing video of the smartphone. It showcases the appearance of the smartphone in reality.
Poco M3 Pro 5G Unboxing Video
From the retail package of the Poco M3 Pro 5G, it appears to bundle the smartphone alongside a few documents, a transparent case, a USB Type-C cable, and a charger. At the front, the smartphone seems to arrive with a punch-hole cutout with a relatively thick chin. It seems to flaunt a 90Hz refresh rate screen and a side-mounted fingerprint sensor.
Running Android 11 topped with MIUI 12.0.5, the Poco M3 Pro 5G seems to be powered by an octa-core 2.2GHz processor along with 6GB RAM and 128GB storage space. Also, there is a hybrid SIM slot to support additional storage. The bottom edge of the upcoming Poco phone flaunts a USB Type-C port, a microphone, and a speaker grille. At the top, the smartphone flaunts another speaker grille and a 3.5mm headphone jack.
Moving on to its rear, the Poco M3 Pro 5G is seen to bestow a triple-camera setup with a 48MP main camera sensor. The other camera sensors in the module include a 2MP macro lens and a 2MP depth sensor. Besides this, the smartphone also flaunts a 13MP selfie camera sensor with 18W rapid charging support. Under its hood, the Poco M3 Pro 5G is claimed to be a rebadged variant of the Redmi Note 10 5G powered by a Dimensity 700 SoC.
Poco M3 Pro 5G Expected Price
Furthermore, it is claimed to arrive in two storage configurations including 4GB RAM 64GB ROM and 6GB RAM + 128GB ROM. As per the tipster Sudhanshu Ambhore, the Poco M3 Pro 5G is said to be priced at 199 euros (approx. Rs. 17,800) and 229 euros (approx. Rs. 20,500) for the two configurations respectively.
The smartphone is said to go on sale from May 20. Also, it is claimed that the Poco M3 Pro 5G will be available at a discounted pricing for the early-bird buyers until May 26. We can expect the smartphone to be launched in three colors – Black, Green and Yellow.
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text:
Since graduating from OCADU in 1986, Fiona Smyth has covered Toronto and elsewhere with her distinctive female charged graphics. Her art practice includes painting, murals, animation, zines, comics, and illustration. Fiona's extensive exhibition history has included group shows at the Art Gallery of York University, the Art Gallery of Mississauga, and the Museum of Contemporary Canadian Art. Her art works have exhibited internationally in the USA, Mexico, Berlin, France, Venice, Taiwan, Korea, and Japan. Fiona teaches illustration and cartooning at OCADU.
A collection of Fiona's Exclaim comics Cheez 100 was published by Pedlar Press in 2001. Her first graphic novel The Never Weres was published by Annick Press in 2011. Fiona illustrated Cory Silverberg's Kickstarter funded picture book What Makes A Baby in 2012, re-released by Seven Stories Press in May 2013. The follow up book Sex Is A Funny Word was released summer 2015.


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Numerical simulation of flame acceleration and deflagration-to-detonation transition in hydrogen-air mixtures with concentration gradients
- Wang C.J, Wen J.X
- International Journal of Hydrogen Energy SCI(E) SCOPUS
- Elsevier in 2016
- Cited Count
The present study aims to test the capability of our newly developed density-based solver, ExplosionFoam, for flame acceleration (FA) and deflagration-to-detonation transition (DDT) in mixtures with concentration gradients which is of important safety concern. The solver is based on the open source computational fluid dynamics (CFD) platform OpenFOAM® and uses the hydrogen-air single-step chemistry and the corresponding transport coefficients developed by the authors. Numerical simulations have been conducted for the experimental set up of Ettner et al. , which involves flame acceleration and DDT in both homogeneous hydrogen-air mixture as well as an inhomogeneous mixture with concentration gradients in an obstucted channel. The predictions demonstrate good quantitative agreement with the experimental measurements in flame tip position, speed and pressure profiles. Qualitatively, the numerical simulations have reproduced well the flame acceleration and DDT phenomena observed in the experiment. The results have revealed that in the computed cases, DDT is induced by the interaction of the precursor inert shock wave with the wall close to high hydrogen concentration rather than with the obstacle. Some vortex pairs appear ahead of the flame due to the interaction between the obstacles and the gas flow caused by combustion-induced expansion, but they soon disappear after the flame passes through them. Hydrogen cannot be completely consumed especially in the fuel rich region. This is of additional safety concern as the unburned hydrogen can be potentially re-ignited once more fresh air is available in an accidental scenario, resulting in subsequent explosions.
1.Combustion regimes in a stratified layer of hydrogen–air mixture. Proceedings of the international congress on advances in nuclear power plants (ICAPP), Nice, France.(2011) Kuznetsov M. et al.
2.Hydrogen combustion in a flat semi-confined layer with respect to the Fukushima Daiichi accident. Proceedings of the international congress on advances in nuclear power plants (ICAPP), chicago.(2012) Kuznetsov M. et al.
3.Influence of concentration gradients on flame acceleration in tubes. Sci Technol Energ Mater. Vol. 72. 7477(2011) Vollmer K.G. et al.
4.Deflagration-to-detonation transition in hydrogen-air mixtures with a concentration gradient. Combust Sci Technol. Vol. 184. 19031915(2012) Vollmer K.G. et al.
5.Flame acceleration in hydrogen/air mixtures with concentration gradients. Combust Sci Technol. Vol. 186. 16501661(2014) Boeck L.R. et al.
6.Criteria for DDT in hydrogen-air mixtures with concentration gradients. 10th international symposium on hazards, prevention and mitigation of industrial explosions, Bergen, Norway.(2014) Boeck L.R. et al.
7.Effiziente numerische Simulation des Deagrations-Detonations-Übergangs.(2013) Ettner F.
8.Numerical simulation of the deflagration-to-detonation transition in inhomogeneous mixtures. J Combust. pp.115(2014) Ettner F. et al.
9.Weak and strong ignition. I. Numerical simulations of shock tube experiments. Combust Flame. Vol. 48. 135148(1982) Oran E.S. et al.
10.A comprehensive modeling study of hydrogen oxidation. Int J Chem Kinet. Vol. 36. 603622(2004) O'Conaire M. et al.


Tens of thousands of demonstrators came out on the streets of Turkey’s capital Ankara and other cities to show support for the goverment in the wake of a failed coup that grabbed world attention. 291 more words
Tags » AK Party
Erdogan seen to emerge stronger from failed coup -- All opposition to be silenced or sidelined -- Or dead
Western leaders and rights groups are now calling for support for Turkey’s elected president
By Stephen Starr
It seemed for a brief few hours on Friday night that Turkey’s autocratic president and the government that backs him would become victims of an enduring touchstone of 20th century politics in Turkey – the military coup. 1,384 more words
Turkey’s ruling Justice and Development Party will hold a fresh leadership election later this month, Prime Minister Ahmet Davutoglu said Thursday.
Davutoglu announced he would not stand in the vote for the party chairmanship, a role he currently holds alongside the premiership, meaning he will also be replaced as prime minister. 76 more words


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Though further research any analysis is needed, the drop in mourning dove and bobwhite quail
counts could be significant. The detailed count data shows these numbers failing off each year.
Cultivated Land Summary
The cultivated land observation area is a five-acre section of cultivated land near the center of a
50-acre field. The field is used to grow corn, wheat, soybeans, and clover, with the crop rotated
annually. In the fifth year of the cycle, the field is left fallow.
The area is located two miles from the nearest paved road and one mile from the nearest
residence. A storage barn is located at the southern border of the field. The table below lists the
This project was initially scheduled to run for ten years, so we are currently in our last year. The
committee needs to decide if it is worth the time and expense to continue the project. The
landowners have experience that they would be happy to let us continue. Costs relating to the
project is minimal and it does provide an opportunity to offer extra credit to students
volunteering as counters.
A suggestion has been made by some committee members that we should increase the count
frequency, counting on a quarterly schedule instead of an annual schedule. This would need to
be coordinated with the owner of the cultivated field so that we do not interfere with planting or
Once again, we would like to offer special thanks to:
We couldn't do this without you.
Add a SmartArt Vertical Bullet List below the text "Once again, we would like to offer special
thanks to: ". Add the text "Frank Mil er" to the top green shape.

domain: agronomy


text:
Embark on an eternal journey and adventure with the silver-plated River ankle chain as your faithful companion. The combination of the classic chain links and raw coin pendants exhibits strength and confidence. The ankle chain can be used for all occasions and is without a doubt the must-have item of the season.
- Silver-plated ankle chain which exudes exclusivity and class
- The stylish coin pendants and fine chain links provide a unique combo
- The ankle chain measures 25 cm + 3 cm extension chain
- Works perfectly with a simple outfit and can be styled in many ways
- A classic and timeless must-have item for your jewellery collection

domain: design


Thomson 50" FLAT DLP TV HD Ready Hi Pix HDTV
- Full and cutting edge connectivity : DVI-HDCP digital inputs to ensure fully digital processing – YUV SynchroScan
HD-Ready compliant with EICTA : This product can successfully display any HD signal such as 720p or 1080i to enjoy the best high definition picture quality
- 3 RGB Scarts - S-Video- AV - Audio : multiple and easy connections for optimum digital and analog image quality
- Virtual Dolby Surround Prologic II (40 W music power) - SRS TruSurroundXT and 7 band graphic equalizer to enjoy the best of cinema surround sound without additional speaker, with dialogue clarity improvement and bass enhancement.
- 2 Tuners PIP (Picture In Picture) / PAP (Picture And Picture) / PAT(Picture And Text) to preview other channels without leaving the one you are watching
- 1200 pages Teletext to view information broadcasted by channels (sport events, programs, stock exchange,...)
Thomson 50" Flat DLP HD TV. Projection type: Rear, Display diagonal: 127 cm (50"), Aspect ratio: 16:9. Audio system: 2 x RMS, Peak Music Power Output (PMPO): 2 W, RMS rated power: 20 W. Teletext: 1200 pages. Colour of product: Black. Power requirements: 230-250 V, 50/60Hz, Power consumption (typical): 190 W, Power consumption (standby): 2.5 W


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Track topics on Twitter Track topics that are important to you
Published on BioPortfolio: 2014-09-22T14:39:12-0400
The outcomes of children with lymphoblastic lymphoma (LBL) in China in our previous study were not unexpected. In this study, through further modification treatment protocols and strengthe...
The purpose of this study is to investigate the clinical efficacy of high-dose methotrexate consolidation therapy for adult patients with BCR-ABL-negative ALL.
The purpose of this study is to determine the safety and effectiveness of a multi-drug regimen (which includes prednisone, vincristine, cytarabine, doxorubicin, 6 mercaptopurine, and metho...
This research study is evaluating drugs called Millennium 9708 (referred to as MLN9708) in combination with standard therapy for acute myeloid leukemia (AML) consisting of daunorubicin and...
RATIONALE: Drugs used in chemotherapy, such as daunorubicin, cytarabine, mercaptopurine, methotrexate, and arsenic trioxide, work in different ways to stop cancer cells from dividing so th...
The combination of intermediate-dose cytarabine plus mitoxantrone (IMA) can induce high complete remission rates with acceptable toxicity in elderly patients with acute myeloid leukemia (AML). We pres...
The incidence of cytarabine-induced pericarditis is rare. So far, only a few cases have been reported worldwide.
Osteosarcoma is the most common primary bone tumor in children and young adults. The median survival of osteosarcoma patients has not significantly improved since 1990, despite administration of diffe...
High-dose chemotherapy and autologous stem cell transplantation (ASCT) is the current standard of care for relapsed non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL). Conditioning regimens with hig...
The treatment of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is based on remission-induction and remission-maintenance. Methotrexate is a widely used immunosuppressant but ...
A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)
Congener of CYTARABINE that is metabolized to cytarabine and thereby maintains a more constant antineoplastic action.
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.
An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA.

domain: biology


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Won the kit in a raffle and have been doing some light research as I knew nothing of the ship or kit. I have picked up the Eduard set for the kit since the best I have seen that is best option given the scale issues of the kit. I think I might have a been a little shop happy as I got the Starfigher Decals too.
The fixes as I understand them:
- Portholes need to be removed
- The island is too skinny but widening (how much?) impacts the deck features
- Picking a year to make as the kits features are conflicting
I get the kit is old and what I have found is some text talking generally about the issues but does any one know of a build that shows someone addressing the issues in detail?
I am thinking I want to show at least one bird on the deck and the elevator raising/lowering with another bird on it. Outside of that I prefer the easiest and most correct version that can be built from the kit just don’t know what and where to modify.
Don’t know if you have seen this or not, but perhaps it may help:
If this is the same kit you have, the review indicates it’s a late war version, which addresses question number 3.
Building any ship, especially a US Navy ship, almost always requires you to decide what period or time frame you intend to depict the model as warships are constantly being updated and upgraded with new technologies and armament which can significantly alter their appearance. Kits (if they are a well researched one) should have taken this in to account and come already manufactured to depict a certain version, but sometimes they’ll get some things right and others, not so much.
One of the best things to do is to try to locate an in depth reference book which chronicles the sort of changes in things like radars, and anti-aircraft armament that the Enterprise underwent during the course of the war, along with paint schemes, which may or may not have been changed.
Luckily, the Enterprise is probably the most famous US warship of WW II and there are a TON of photos available and that should help.
The OTHER problem you have with an aircraft carrier is that you also need to ensure that the composition and painting of the planes in the attached Air Group are consistent with the period in which you’re depicting the ship, so for example no Corsairs or Hellcats if you’re depicting her at Midway, or no TBDs if she’s being depicted as a 1945 night carrier.
While not a build log, and without any aircraft, this appears to be an excellent build of a Tamiya 1/700 Enterprise in her late war configuration as shown by the radar suite and all the 40mm and 20mm AA guns
Thanks I don’t know if I saw that one. The build linked is basically what I want to do but with a plane or two on the deck.
Two excellent references which can provide a lot of detail to decide how to model the ship based on the period you wish to depict are:
U.S. Aircraft Carriers, by Norman Friedman, and Aircraft Carriers of the U.S. Navy, by Stefan Terzibaschitsch.
terrible that she was scrapped and not made into a museum

domain: hobby


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Several days ago I wrote about how Grain Surfboards turned their products into an experience. Besides selling wooden surfboards, Grain Surfboards also offers classes in how to build your own board. I took the 4-day class this past long weekend.Read More
I admit I am a big geek when it comes to the long drawn out US presidential campaign season. I enjoy the marketing and PR aspects immensely.
Many people think the two-year campaign is too long. Not me. I love all the debates and speeches and talk show appearances and news coverage.
Last week, Marketing Lessons from the Grateful Dead, which I wrote with HubSpot CEO Brian Halligan was released in the Japanese language. The book is doing great. It's been ranked in the top 20 or so of all books sold on Amazon Japan and most physical bookstores have already sold out so the publisher has ordered another print run. Brian & I are psyched to introduce the ideas of Grateful Dead marketing to Japanese businesses.Read More


Douglas County American Dairy Association to host free lunch
Published 06/01/2012, Alexandria Echo Press
The Douglas County American Dairy Association will host Lunch on the Farm on June 9 from 11 a.m. to 3 p.m. at Bill Dropik's Farm (next to Trophy's on Highway 27 by Nelson).Word count: 61
The full article is available to newspaper subscribers. If you are a subscriber please log in to continue reading.


An interesting story on the voting trends of Catholics... It also contains a quote from member Steve Krueger.
By Matt Bigelow
The Catholic swing vote will determine this year's Democratic primary and may break for Illinois Senator Barack Obama in Texas and Ohio on March 4, according to pollsters, political scientists, and Catholic priests who have tracked Catholic turnout. While early in the campaign Senator Hillary Cliton could rely on substantial support among Catholic voters—she enjoyed a two-to-one margin over her opponent in states such as California and New Jersey—Obama has in recent weeks trimmed back that margin.


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Goldco – Our Top Choice
Concerning Goldco Valuable Metals
GoldcoGoldco is actually a top metals business leader, whose specialized is providing tax-advantaged self-directed Individual retirement accounts that are actually permitted to keep precious metals by the internal revenue service, though Non-IRA gold and silvers are actually also offered.
Established in 2006 through Trevor Gerszt, as well as rebranding as Goldco in 2011, they have actually helped countless individuals and families around the country properly get in the metals investment sector.
They have actually rightfully gotten some of the best gold dealer rankings in the business, thanks to their higher requirements of putting their clients at the facility of every thing that they perform, which can be actually affirmed on all major trusted testimonial websites.
From Goldco Priceless Metals:
We put in the time to know each person’s assets targets and objectives. We additionally provide the information as well as resources they require to develop a rare-earth elements collection that will definitely help them achieve their targets. Our business as well as online reputation are built on trust, and also the relationships our consumers develop along with their individual Gold IRA experts are an extension of that very same rely on.
We preserve 5 celebrity ratings of buyer count on web sites like Customer Affairs, TrustLink, TrustPilot, and also the BBB.”GET Goldco's FREE GUIDE
Why Select Goldco?
Aid recognize the most effective method for including metals to a brand-new or even existing IRA account, and also deliver the relevant information as well as information needed to choose what types of precious metals make good sense for the customer
Job directly with the company that handles the old profile, to roll-over the assets from the existing 401( k) or IRA in a tax-free, fine free of cost purchase
Swap some or even each of the customer’s paper-backed properties for bodily gold and silver
Our team sustain the highest possible specifications for client contentment.
Why Our Company Trust Goldco
Gold for RetirementWhen administering our due diligence on Goldco prior to presenting them to our target market, we were rather amazed at just how they differ in the business in evaluation to very most gold investment firm.
Where their competitions have a tendency to, pardon our company for saying so, shove specific financial investments down their prospects’ throats, Goldco alternatively, as confirmed by their 3rd party Goldco evaluation rely on profiles, present a truthful dedication to accurate customer support, patiently committing their opportunity and know-how to properly identify what their prospect’s needs are actually based on their individual scenario, not “one hat suits all” as this is hardly ever in the prospect’s best interests.
Goldco may not be actually at the same time called various other gold individual retirement account providers or even the least expensive, but our company do not think they’ll fall short of your requirements as your depended on rare-earth elements investment firm.
Gold IRAs and also Gold 401k Rollovers
Gold IRA ServicesGoldco is actually ideal acknowledged today as a Priceless Metals individual retirement account specialist, assisting their clients start, carry over or even move their experienced retirement plan in to a Self-Directed IRA having a practical portion of bodily metals as a bush versus existing and future financial uncertainties.
This often tends to become helpful for entrepreneurs that need to have, or even simply desire, to transform or reduce the danger of their traditional “paper resources” retirement plan with “actual properties” like gold, because of its own time-tested as well as effective make use of (several many thousand years right now …) as an establishment of wide range and hedge against financial anxiety and political risk.
In this existing uncertain financial as well as political truth that we find our own selves in currently as well as moving forward, it’s right now, and feel free to pardon us for being blunt, definitely necessary to certainly not stay non-diversified with only stocks, connections, mutual funds, as well as other newspaper possessions in your portfolio.
One sturdy example where gold had confirmed its own accurate market value resided in the Financial Problems of 2007– 2008 which viewed the hard-earned pension of numerous Americans shed 40% or even even more of their market value practically through the night– where those that had actually planned ahead along with gold in a Self-Directed IRA observed well-balanced rises in their profiles, as gold costs removed in feedback which assisted safeguard their accounts coming from devastating losses.
Goldco’s totally free eye-opening Gold Investment Set strolls you via the various perks gold-backed Self-Directed IRAs offer to you with the help of their built-in income tax performance which offers an included layer of safety and security for you.
To help real estate investors start on their metals journey, Goldco has actually offered approximately $10,000 in Free * Silver for all brand new qualified individual retirement account and cash investment profiles. To state it, all you require to become allow your metals expert find out about it when they call to prepare freight of your totally free kit.
Concerning Portfolio Resource Variation
Gold for Portfolio Property DiversificationNow, for clients and also retirees who are actually certainly not considering getting gold in a tax-efficient Self-Directed individual retirement account, Goldco delivers skilled suggestions in regards to the appropriate diversity of one’s assets portfolio and also as discussed previously, provide Non-IRA rare-earth elements to their clients.
Their very experienced, certified group of consultants provide cost-free personalized consultations to capitalists to help them choose what the most ideal percentages would be concerning the add-on of gold and silvers to any kind of profile; based upon their individual threat hunger, economic objectives, and also total requirements.
CLICK HERE CURRENTLY to state your absolutely no-obligation 2021 Gold individual retirement account Package today, which likewise includes a completely free of cost examination along with an expert metals expert.
Goldco’s Unbeatable Strategy
The gold and silvers sector is actually remarkably affordable, controlled by extremely strict revenue margins. To create their consumer bottom, many business have been captured spiraling down a great void by lowering prices, creating pledges that are too good to become true as well as in an uncomfortably couple of high profile situations traversing business values series in to straight-out fraud at their clients’ cost.
Squeezing cents does financial danger certainly not just to their consumers but it additionally wastes at the provider’s track record and financial status. Within the past many years, 8 leading gold dealerships have actually declared bankruptcy or have actually been straight-out stopped due to the CFTC, leaving their clients out in the chilly for countless bucks as well as binding their metals in badly long and pricey courtroom struggles.
Goldco, nevertheless, seems to practice the viewpoint that placing their clients at the center of whatever they carry out in relations to providing the most effective possible solution is actually the only method to carry out company, just like it should be actually.
We acknowledge that they often tend to be even more pricey than their least expensive budget rivals. However, what they give the table for you in phrases premium solution much exceeds this issue (to put it simply you get what you spend for, in this case that transcends dependable company and the comfort that comes along from it).
Gold individual retirement account ServicesNow as competitors’ cost-cutting presses commission-only purchases staffs into performing their absolute best to get every penny they can from their prospective clients, Goldco’s primary target remains to be about creating a tough customer-centric group of professionals that are actually paid out rather as well as strongly valued for the precious metals experience and also know-how they bring to the desk on your behalf.
This guard makes certain that every customer regularly receives tips that’s best for their specific conditions– not a to an excessive degree string of annoying and also tiresome high-pressure salesmanship for whatever spends the best payments.
Keeping that pointed out, it is actually no surprise to our team whatsoever that Goldco continually costs as the “Hey, most likely to this gold investment firm. They took terrific care of me …” in the United States, consistently gaining a number of business awards scheduled for the very best gold ira companies due their first-rate client service.
Enlightened Spending Way Smart Investing
At Gold for Retirement, our team always recommend that you perform your appropriate due diligence and receive each of the truths that you need to make informed decisions. Goldco precisely allotments this ideology, which is illustrated wonderfully in the definitely complimentary instructional entrepreneur plans that they happily send out to all prospective customers that request for them.
Using this expert relevant information in hand coming from those that recognize the gold markets well, described in layperson’s phrases, potential and also existing clients can simply make sound assets choices assisted through precise information, not hype and/or marketing mumbo jumbo whose simply merely purpose is to fatten gold dealer purses.
Goldco upon ask for puts together totally customized financier sets that match their possible customers’ necessities and also certainly not the other means around.
Each physical pack a possible customer purchases usually tends to be acquired in the mail 1-2 days after requesting the plan, leaving behind rivals in the dust through around 6 days.
Personalized to your investment needs and objectives, your individualized Gold individual retirement account client package may be BOUGHT HERE to acquaint your own self in even more particular along with the provider.
Pros and cons
Similar to any type of business, Goldco possesses its own benefits and drawbacks. See to it you think about both just before determining where to open your gold IRA account.
Excellent evaluations as well as ratings
Permits you to open an IRA as well as buy metals in one place
Lots of helpful online information to learn from
High minimum expenditure
No openly readily available expenses or even costs
Just how can I withdraw from my account?
Though you can actually remove funds coming from your gold IRA at any moment, you are going to be obligated to repay a 10% fine if doing this prior to age 59.5. After you attack 59.5, drawbacks are actually tax-free.
Through grow older 72, you’re called for to begin taking minimal distributions, per internal revenue service guidelines.
Where to find Goldco substitutes
Goldco may assist you both accessible your account, fund it, as well as obtain your silver and gold assets. Bear in mind, though: It’s certainly not your only alternative. There are actually lots of precious metal individual retirement account providers out there, therefore ensure to review your possibilities if you want the best company as well as fees. Use our gold IRA guide to get started.
How our company measured Goldco
Our rating for Goldco was determined by assessing our partners based on numerous aspects. These elements consisted of BBB rating, Trustpilot score, yearly fees, informative information, client help, and assortment of precious metal coins and also bars.
When a credit rating was actually delegated, we at that point recognized where each company stood out among its competitors to generate our selections of what each provider was actually the most ideal for.
Augusta Gold and silvers will certainly be actually keeping a free webinar online on daily at once of your finding called The Webinar That Will Adjustment The Means You Resign. This webinar will expose every little thing the real estate investor requires to find out about gold IRA acquiring todays economic condition and just how it related to the investor’s individual circumstance.
Devlyn Steele and also hall of fame quarterback Joe Montana will certainly be leading the discussion and also states this webinar is actually an odds for individuals to speak with field forerunners on Gold supported individual retirement account investing. They may inquire inquiries stay and also receive relevant information certainly not easily available with other stations.
Folks curious about Gold supported IRA committing can easily register free listed below _________.
Regarding Augusta Valuable Metals
Augusta Gold and silvers was founded in 2000’s as well as offers the Committing and Financial industry. It is actually understood for It is actually unaffected credibility as the very best metals expert firm in the United States along with over 600 beneficial evaluations throughout all planforms. It likewise boasts to have actually never ever gotten a single negative testimonial online while doing business.
The provider has actually been measured amount 2 total as the best gold IRA firm through our company. They have acquired this primary ranking for USA located gold business on a sizable assortment of customer support relevant elements.
Augusta Metals holds the highest considers as a component of the Bbb, Trustlink, Facebook, Google and also The Buyer Alliance.
Regarding Utmost Gold Financial Investment Customer Review
Ideal Gold Financial Investment Customer review is a ranking site in the monetary and also investing space. The ranking elements are actually declared to be performed by experiencing each business with the eyes of the customer and supplying comprehensive accountancies of what to expect when selecting a particular firm.
In the case of Augusta Metals, the company has actually surpassed all benchmarks established through its competitors as well as has gotten it the best advised business for self-reliant Gold individual retirement account accounts in the USA.
About Gold IRA Spending
Gold individual retirement account investing is actually an economic method made use of by business, individuals as well as countries to hedge versus unit of currencies and inadequate market health conditions. Throughout past, it has actually been called a device made use of on every amount of spending as a stable car for securing lasting funds.
If you are looking at acquiring gold as well as need to know even more regarding the perks of buying Augusta metals, below’s some details on our metals refining & gathering establishments. Right here is actually a brief malfunction of some essential benefits and drawbacks concerning using the Providers of Augusta Valuable Metals: pros. The best pros to selecting a Gold individual retirement account consist of: extraordinary customer support, steady, almost infinite, normal, first-class assessments. No stated grievances to day as company s end. Easy, easy, high- clear open-outstanding gold IRA account opening method.
The 2nd biggest pro is purchasing Augusta Priceless Metals. This set drops right in between our first pair of pros. Augusta delivers a sensible assortment of different resources for variation. We recommend that you put together an IRA collection which is actually 100% based upon gold and/or silver. If you would love to include other gold and silvers to your collection, it will certainly be actually simple to add all of them also. This is one of the few places where you may set aside a part of your funds and purchase each one of the metals together.
One more perk to think about is our lifetime customer provide. It is a completely outstanding function that our company offer. If you sign up with our team you will certainly have life-time accessibility to all of our gold IRA alternatives. You may simply transform a routine financial investment into a significant gold individual retirement account. If you ever desire to shift out metals for yet another assets, you may equally as easily liquidate your remaining balances and also begin again along with a fresh financial profile.
Our company gives the complying with seven metallics for our consumers to select from. They are actually all certified as possessing long-lasting development possibility. They additionally are considered to become among the best financially safe and secure and also safe alternate properties offered to customers. These rare-earth elements include gold, silver, platinum eagle, palladium, ruthenium, osmium, and iridium. Despite which metal you select, our company can make sure it is going to be actually a highly financially rewarding expanding selection for you and your loved ones.
There are actually several reasons folks diversify their expenditures at presents. One of the absolute most popular factors is actually considering that paper assets (the standard matchings of gold, silver, platinum, and palladium) are actually ending up being also costly for the ordinary individual. While gold and silver are actually consistently highly cherished, purchasing gold and silvers as an included diversifier provides you an extremely versatile resource that is constantly useful in different economic ailments. Purchasing gold and silver is both a sound long-lasting investment in addition to a solid rising cost of living hedge. Purchasing these metals as gold and silvers is actually also a smart methods of investing in substitute possessions throughout an opportunity of political chaos or financial depression. Gold and silver pieces are only a few of one of the most well-liked expanding retirement accounts nowadays.
The benefits of transforming your investments along with Augusta precious metals are actually numerous. First off, by transforming into gold, silver, platinum, palladium, and various other metallics, you may get rid of a lot of threat from your collection. The value of the metals rises as well as declines (similar to the worth of every other supply) based on the state of the economic situation. This indicates that immediately, if you have a wad of gold, you can count on to obtain even more money when the economy strengthens, than if you had a pile of silver. Gold is a bush against inflation, and also through acquiring as much gold as you may afford, you are actually guaranteeing that you are going to never drop any kind of cash in the economy.
An additional benefit of owning these metallics is actually that they are strongly tax-efficient. The government may not promote residents to spend in gold and silver gold, it carries out not penalize residents for buying as well as storing the metals on their own. For this reason, the IRS-approved physical silver and gold coins are a wonderful assets and also readily available to every American resident.
The USA Federal Government has an IRA-approved physical gold and silver plan that enables you to invest carefully in this asset lesson without must spend the additional tax obligation required by possessing an IRA. There are actually no annual expenses related to owning these gold and silvers, thus there is actually no additional worry on you whatsoever. Having said that, if you possess a profile with a broker that charges a brokerage firm percentage, you may be much better off buying as well as holding the metallics on your own. If you yearn for the advantage of possessing gold on your own, without the risk of shedding your investment funds, then of course acquire the pieces and also store them up until you select to offer all of them.

domain: finance


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The Dead Kenny G's played Yoshi's just before we left for vacation. I tried to write about them then but the PC crashed and I just gave up. I know virtually nothing about them accept what I read on their web site, I just love the name. Check them out. There is lots of interesting reading. www.thedeadkennygs.com
This trio of shape shifting musicians shatters musical paradigms by melding elements of jazz, classical, and eastern music over the soundtrack of a punk rock life.

domain: entertainment


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Following the video UFC interim light heavyweight champion Jon Jones published over the weekend, wherein he said he’ll be back “really soon,” Dana White chimed in and said things might be looking up. The UFC president was a guest on Jim Rome’s radio show on Tuesday and claimed he received information that could point to good news for Jones, backing the fighter’s statement about returning to fighting sooner than later. “It’s coming back now that it looks like [Jones] did not take the supplement that everybody thought he took,” White said. RELATED > Jon Jones Says He’ll Be Back in the Octagon ‘Really Soon’ Jones was flagged by the United States Anti-Doping Agency (USADA) in July for banned substances.
Read more from the original source:
Dana White Says it Looks Like Jon Jones Took ‘Something Else,’ Could Be Good News – MMA Weekly


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Having a consistent rule across all healthcare settings will avoid confusion for the public.
The British Medical Association (BMA) has called for face masks to become compulsory for patients visiting GP practices.
It comes after Matt Hancock, the Secretary of State for Health and Social Care, announced that from 15 June they would be mandatory for all visitors to hospitals.
This followed recommendations from the Scientific Advisory Group for Emergencies (SAGE) highlighting that face coverings can help reduce the risk of transmission if a patient is suffering from coronavirus, but not showing symptoms.
BMA council chair Dr Chaand Nagpaul said: “The newly announced face-covering measures in hospitals must also be extended to cover GP surgeries and other health, community and social care settings.
“As this virus knows no boundaries, it is important that there is consistency around face coverings that applies throughout healthcare settings, reflective of the integrated health care system we have.
“It is extremely concerning to hear that there has been no consultation with hospital trusts on how this will work in practice for them, or with GPs about any future plans. If we are to have confidence in the Government’s ability to deliver on this, they must be forthcoming immediately on the details of how this will work.
“Whilst many GP practices have taken major steps to reduce face-to-face consultations, encouraging patients to wear a face-covering when attending a practice will help further protect staff and patients.
“Having a consistent rule across all healthcare settings will avoid confusion for the public and make life easier for the staff and healthcare workers who will be trying to implement these safety measures.
“There remains a serious concern about the availability of medical masks in general practice and community settings and this must also be addressed as a matter of urgency. The Government must ensure that there are sufficient supplies of medical masks across all healthcare settings and be very clear with the public about what type of covering they need, how they need to wear it and where they need to get this from.
With the UK death toll now tragically over 40,000, the BMA says “it is absolutely crucial that the Government gets this right as protecting the health of the nation is paramount.”

domain: medical


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EMBARCADÈRE DES CAPUCINES
L'Embarcadère des Capucines offers you electric boats to discover the Marais Poitevin in a whole new way!
Reservations must be made by telephone. The conditions of the rides have been modified and adapted to health requirements for the safety and comfort of all.
The Embarcadère des Capucines offers you the chance to discover the Sèvre Niortaise in the heart of the Marais Poitevin by electric boat.
Let yourself be lulled by the serenity of this silent ride, as you discover the flora and fauna of the Marais! Handy and accessible to all, with their "Capucine" roof and fold-out table, you can picnic on board.
You can also sample the flavours of Vendée cuisine with a boat trip and a meal in a picnic area, for a magical break!
Discover the fauna up close, with canoe hire! And enjoy a nature break in the South Vendée.
Facilities & amenities
- Wifi access
- Pets allowed

domain: travel


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And the LORDspake unto Moses,saying ,
2Speak unto the children of Israel, that they bring me an offering: of every man that giveth it willingly with his heart ye shall take my offering.3
And this is the offeringa which ye shall take of them; gold, and silver, and brass,4
And blue, and purple, and scarlet , and fine linen, and goats' hair,
And rams'skins dyed red , and badgers'skins, and shittimwood,6Oil for the light,spices for anointingoil, and for sweetincense,7Onyxstones, and stones to be set in the ephod, and in the breastplate.


The latest season of Big Sky brings with it big changes, starting with a new title Big Sky: Deadly Trails. That’s just the beginning for the Montana-based mystery series known for delivering thrilling stories and endearing characters over the last two seasons. Season three promises bigger mysteries by pairing season-long storylines with episodic thriller episodes, plus the addition of a pair of big stars Reba McEntire and Jensen Ackles.
Don’t worry though, Deadly Trails will continue to offer much of the same Big Sky intrigue and excitement fans have come to love starting with the return of stars Katheryn Winnick and Kylie Bunbury as undersheriff Jenny Hoyt and Private detective Cassie Dewell. The dynamic duo are back to investigate all the strange doings headed to Helena, Montana as only they can. With a missing backpacker, a new sheriff in town and a murderer on the loose, there’s going to be a lot to love.
The stars of Big Sky: Deadly Trails recently discussed the series during the 2022 Summer TCA Press Tour where McEntire and Ackles explained why they decided to join the series. “To get to come on this show with such wonderful characters already established and with great storylines,” said McEntire who plays outfitter Sunny Barnes – a character who wears a smile but may be hiding something behind it. “I am looking forward to every time I get a script to see what happens, that’s when I know the audience is going to be entertained and that’s what drew me to this show. It’s wonderfully exciting and I just can’t wait to know what’s going to happen.”
“When my initial conversation with Elwood (Showrunner/Executive Producer Elwood Reid) took place, he mentioned shaking some stuff up for season three, and I thought I can shake,” joked Ackles. “I feel like it was a natural fit and it was an opportunity to come and work with some really grade-A actors and work with some awesome story,” he continued. “Really, it just came down to the fact that he said Reba was coming too. I was in. I was in a penny for a pound. That’s it.”
Kylie Bunbury discussed the addition of the newly appointed sheriff, Beau Arlen (played by Ackles) to the mix. “I feel like we are being blessed with the opportunity to work with two consummate professionals who are really good at what they do but also bring a certain energy that makes you just feel excited to work, excited to be here.” She continued, “We get to learn from them as well. And, yeah, it’s honestly just a privilege to be able to work with the both of them, and that we do this every season.”
After fifteen seasons of the wildly popular Supernatural, Ackles looks forward to a new challenge of on Deadly Trails. “At the end of the day, you try to find what is really at the heart of these characters. Talking about their own kind of justice, that’s the interesting thing – these characters, they all think they’re right. Whether they’re wrong or not, they’re doing what they feel is right in their heart,” explained Ackles.
The actor also mentioned a story of a famous actor who played bad guys his whole career being asked, ‘Why do you always play bad guys?’ “He said, ‘I’ve never played a bad guy in my life,’ continued Ackles. “And I think that that kind of — if you take that approach with any character, then it has a little bit more complexity than just playing a bad guy.”
“This year was could we tell an enclosed mystery story along with our longer arced out story of the season. It’s a puzzle,” said Reid. One of this season’s biggest puzzles viewers can’t wait to solve, will we get to hear Reba sing? Reid teased the answer fans were hoping for, “As far as her character, I think when you see her arc, there may be a little bit space for her to sing, but she’s on a pretty dark journey right now trying to hold this messed up family together. Might be a murder ballad.” We can’t wait.
Get your cowboy boots, grab your badges and prepare for a wild ride, because as Winnick explained, “It feels like it’s a whole new season this year. It really does. A whole new script, in terms of the storylines, it’s completely different, new cast, new energy.”
Big Sky: Deadly Trails premieres Wednesday, September 21, at 10 p.m. on ABC.


Warren Buffett vs. the greens
LAS VEGAS — Another billionaire is angering environmentalists these days: Democratic hero Warren Buffett.
For Democrats, the world’s third-richest person is a champion who has advocated higher taxes for millionaires and donated money to put Hillary Clinton in the White House. But green-energy advocates are expressing increasing frustration with Buffett, whose sprawling business empire is opposing them on fronts including solar power, oil train safety and the Keystone XL oil pipeline.
The friction is evident in Nevada, where a Buffett-owned power utility, NV Energy, is fighting to hike the costs for residents to use rooftop solar panels — a push that’s similar to campaigns being promoted around the country by groups tied to conservative billionaires Charles and David Koch. President Barack Obama and Senate Democratic leader Harry Reid slammed that effort during a clean-energy summit last week in Las Vegas, although Obama aimed his criticism most directly at the Kochs and Reid noted that Buffett has put huge money into wind and solar power, too.
Others were far less reluctant to point the finger.
“Buffett, through NV Energy, is attacking rooftop solar because it directly competes with his monopoly,” said Lauren Randall, the public policy manager for the major residential rooftop solar company SunRun. She denounced the utility’s solar push as an “extreme anti-consumer proposal.”
Greens in regions like the Pacific Northwest, as well as the top Democrat on the Senate’s energy panel, are also criticizing Buffett-owned Berkshire Hathaway Energy for trying to weaken a 1978 federal incentive program for wind, solar and other renewable power.
And Buffett supports approving Keystone, the long-delayed oil pipeline that has sparked a nationwide opposition movement by climate activists and angry protests in the Oracle of Omaha’s home state of Nebraska. He told CNBC in March that Keystone is probably “good for the country,” which would run afoul of the White House’s messaging if Obama ultimately kills the project as expected.
The Republican National Committee is trying to turnBuffett into a Clinton problem, saying his activities show a stark conflict between the Democratic front-runner and one of her most visible backers.
“Energy issues are another example of how Hillary Clinton is caught between her major donors and the grass roots,” RNC spokesman Michael Short said. “Environmentalists and the left are right to question whether they can trust Clinton when she and [the Clinton] foundation are busy taking money from those who don’t share their priorities.”
Neither Berkshire Hathaway nor the Clinton campaign responded to requests for comment.
Most Democrats hesitate to publicly criticize Buffett. But privately, some green-minded Democrats acknowledge that Buffett’s business priorities often conflict with Clinton’s and Obama’s renewable energy agendas.
“What’s good for Buffett might not necessarily be good for the clean power sector,” one environmentalist following the issue said.
The mismatch points to another reality about Buffett: his reluctance to use his vast personal wealth to promote his personal political agenda, unlike liberal billionaire Tom Steyer and conservatives such as Sheldon Adelson and the Kochs.
“Philosophically and politically [Buffett is] probably out there hoping to continue to promote greener energy,” said economist Charles Cicchetti, who used to work with Buffett’s companies and more recently consulted for the rooftop solar company SolarCity. “But there’s a gap between his brain and his [business] philosophy. He hires aggressive people who are out there to win at any cost. He doesn’t acquire utilities so they can enhance the public good.”
In the Nevada rooftop solar dispute, Buffett’s company is largely on the same page as the Koch brothers in seeking to cut incentives and impose extra fees on residents who use their solar panels to sell excess electricity back to the power grid — a move that greens warn would make installing the panels unaffordable for many people.
Obama alluded to the controversy in his keynote speech at last Monday’s energy summit, excoriating utilities that stand in the way of rooftop solar power and other clean energy innovations.
“So here, and across the country, this is about whether big polluters control the system, or whether consumers have freedom to choose cleaner, cheaper, more efficient energy; whether we protect old ways of doing business even when they’re not efficient, or we dream up new business models that bring new technologies into our homes and businesses, and new jobs into our communities,” the president said.
Clinton has also warned against utilities putting up new roadblocks for solar power. “No. 1, we’ve got to prevent backsliding,” she said in July. “That’s why I said watch out for utilities that want to stop clean renewable energy and enabling customers to sell back to the grid, because they want to prevent the transition.”
Reid, who hosted last week’s energy summit, said Buffett’s company has “to get real on rooftop solar, understand that there’s a new world out there.”
“If NV Energy goes on the path they’re going, they’ll almost certainly end up losing” in the court of public opinion, Reid said. Still, he said Buffett’s purchase of NV Energy in 2013 has ultimately “been good” for the state.
Buffett’s Berkshire Hathaway is one of the biggest conglomerates in the country, with holdings ranging from insurer Geico to Fruit of the Loom. It is deeply entrenched in the energy industry through its ownership of Nevada’s NV Energy and MidAmerican Energy, as well as BNSF, the biggest U.S. railway oil shipper and a major transporter of coal.
Buffett has famously pledged to donate his vast fortune to philanthropic groups like the Bill and Melinda Gates Foundation, and he’s avoided bankrolling political candidates — even Clinton, whom he once called“one of my favorite women in the world.”
He has publicly backed Clinton and predicted she will win the presidency next year, but he gave a relatively modest $25,000 last year to the Ready for Hillary super PAC (now the ReadyPAC), the committee’s self-imposed maximum, and donated$2,700 to Clinton’s campaign in April.
Earlier this year, Buffett told CNN that he doesn’t plan to write “a huge check” for Clinton because he doesn’t believe that “elections should be decided by the super-rich.”
“I like what she believes in, and I think she’s extraordinarily able and energetic, for that matter, in pushing those beliefs. I don’t see how you could have anyone better qualified,” he said in a 2012 interview.
He backed both Clinton and Obama in 2008, joking recently that it’s the only time he’s “been a bigamist.”
While Berkshire’s fossil fuel operations may rub up against some Democrats’ priorities, other parts of the business make liberals swoon. MidAmerican Energy is the largest regulated wind power owner in the country, operating 2,285 megawatts of capacity, or slightly more than the output of two big nuclear reactors. That figure is set to grow to 3,335 megawatts, the company says, making up almost 40 percent of MidAmerican’s electricity generating capacity.
MidAmerican’s solar business also owns one of the world’s largest solar plants, the 550-megawatt Topaz Solar Farms in California, and is developing the 579-megawatt Solar Star projects in California’s Kern and Los Angeles counties. And it owns a 49 percent interest in the 290-megawatt Agua Caliente solar project in Yuma County, Arizona.
People following Buffett said he backs Democrats like Clinton not because it will boost his company’s profits, but because his personal beliefs align more closely with the left.
“Part of the reason that he leans progressive on the political side is that he’s made enough money that he just thinks it’s right,” said one energy lawyer with ties to Democrats. “I don’t think an investment in Clinton by him is really an investment for the Berkshire Hathaway empire.
“Frankly, there are probably some of his businesses that would be better off under a Republican president than a Democratic one. But that’s not what moves him.”
Meanwhile, parts of Buffett’s empire are moving in directions that leave greens and liberals fuming.
Berkshire Hathaway’s BNSF Railway has lobbied the White Houseagainst some safety regulationsmeant to prevent explosive derailmentsby oil trains, and earlier this summer, Berkshire infuriated Washington state Sen. Maria Cantwell, the top Democrat on the Senate Energy and Natural Resources Committee, by pushing to weaken a 1978 law requiring it to buy power from small renewable power generators.
Jonathan Weisgall, vice president for legislative and regulatory affairs at Berkshire Hathaway Energy, recommendedreworking the Public Utility Regulatory Policies Act of 1978, which was designed to expand renewable energy, saying the changes would protect utility customers from “unnecessary costs and inefficiencies.” But Cantwell accused Berkshire of trying to hamper green power to boost its own profits, and she added a dig at BNSF on the oil trains controversy.
“I just see you making money coming and going on the repeal of this PURPA language,” Cantwell toldWeisgall at a hearing in May. “To me, it’s bothersome, to say nothing of oil trains and your slow response on removing old oil trains. Now you’re coming in here and trying to undo a very important law.”
Rachel Shimshak, executive director of the Oregon-based advocacy group Renewable Northwest, said the push against the 1978 law is a sign of Berkshire Hathaway Energy-owned utility PacifiCorp’s reluctance to embrace more green power. “They’re hanging on to a lot of dirty plants,” she said.
But people following the billionaire’s energy plays say they aren’t surprised about the disconnect between Buffett’s political leanings and business dealings. Buffett, they say, is running a corporation, not a political campaign.
“He’s like any other powerful special interest entity in Washington, D.C., pursuing a narrow strategy to benefit his financial position without a real regard for larger, overarching policy goals or ideals,” said Tyson Slocum, the director of Public Citizen’s energy program, who has long criticized Berkshire. “It’s not evil. He’s doing what every other vested interest in Washington does.”
Indeed, Buffett’s businesses’ “all of the above” approach to energy investments makes it difficult to fit neatly into traditional ideological frames, complicating his role as a political player.
“While Warren Buffett often offers his ‘personal’ opinion on politics, legislation, taxes, elections and the economy, they do not represent the opinion of his vast network of subsidiary companies,” said Robert Miles, the author of two books on Buffett and a Berkshire Hathaway shareholder.
When it comes to the myriad businesses owned by Berkshire Hathaway, Buffett is notoriously “hands-off,” Miles said
“Each company has a manager that is free to run their business as best they see fit,” he said. “So any energy-related policy, legislation, strategic decision would be made by Berkshire Hathaway Energy executives without checking with Warren.”


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The country will enter a six-week lockdown from midnight on Wednesday.
Cabinet Ministers have approved moving to Level 5 of the 'Living With Covid-19' plan - with some tweaks - until the start of December.
The measures will be reviewed after four weeks if they are working effectively.
Changes will be made to wage supports.
A new band will be added to the Pandemic Unemployment Payment meaning anyone who was earning more than 400 euros a week before losing their job will get a payment of 350 euros a week.
Schools and creches will stay open.
Elite sport, including inter-county GAA & the Six Nations, will also be allowed to go ahead.
Children can play sport in outdoor pods of no more than 15.
People will be told not to move more than 5 kilometres from their home with a graduated system of penalties including fines being worked on.
A so-called bubble system aims to ensure vulnerable people or those at risk of social isolation are not left alone.
Attendance at weddings is to be maintained at 25 and those who can work form home should continue to do so.
Construction sites will stay open, but all non-essential retail will close, putting hundreds of thousands of jobs at risk.
The Taoiseach said in a statement tonight he was asking everyone to take the threat of the virus seriously.
But he said if everyone pulled together over the next six weeks we could have the opportunity to celebrate Christmas in a meaningful way.
He said the journey ahead would not be easy but the future was in our hands.
The development came as 235 new cases of the deadly bug were confirmed in the capital.
The Department of Health reported 1,031 cases of COVID-19 around the country.
The total number of infections has now passed 50 thousand.
No one's died from the disease in the past 24 hours.
The latest figures also show 298 people are in hospital being treated for coronavirus, an increase of 20 since yesterday.
34 people are in intensive care.


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©2022 ECSTATIC DANCE
Ecstatic Dance London: Ecstatic Saturdays Indoors @ Siobhan Davies Dance Studio
Saturday evenings of unfacilitated free-style ecstatic dance with the pioneers of ecstatic dance in the UK since 2009 –
Ecstatic Dance London!
Ecstatic Dance + Cacao Ceremony
(Complimentary Raw Vegan Cacao for all dancers!)
No booze, No Shoes, No Chit Chat, Move However You Wish!
We love to dance. We love music. We love to inspire, to connect, to heal and transform!
MUSIC – MOVEMENT – COMMUNITY!
WHAT TO EXPECT:
-Next-level, conscious, inspiring versatile dance music with live percussion
-A beautiful, sacred, heartful, fun & safe space for you to dance freely in
-Yummy, velvety tasting raw vegan cacao drink and intention setting ritual
-Superb sound system and optional silent disco headphones for more immersive experience
-Vibrant people who love to dance and love music!
-Optional social with refreshing fruit to nourish you after the dance
-Best Saturday night out and no hangover!
We are offering two dance classes in the evening! Online bookings only, no spaces on the door due to limited capacity!
◈ For 5:45pm 8:00pm (regular session)
◈ For 8:15pm-10:30pm (genre specific session)
– Low waged/Concession £15
– Regular/Abundance £20-£25
-We’ll let the music, the community and our own inner space direct our steps, our movements, our expression, our journey.
-You and your awesome friends are invited to join us for weekly freestyle, expressive dance & moving meditation classes. An Evening of Ecstatic Dance with No Alcohol, No Drugs – Just Music, Amazing Rhythms and Cacao!
-Our Ecstatic Dance classes create a safe and respectful environment that embraces ‘all ways’. We offer a movement practice that supports your free expression of emotions and inner space through movement and music.
-Our intention for these Ecstatic Dance classes is self-exploration, connection, fun, healing, expanding human potential and community building through freestyle ecstatic dance.
-No experience necessary. Move your Body, unleash the wild dancing self, claim your freedom, open your heart & touch the infinite!
-Let’s dance together! Enjoy our Ecstatic Dance journeys, keep the wonderful ecstatic dance energies awake, alive, and aligned!
Our ‘𝗘𝗰𝘀𝘁𝗮𝘁𝗶𝗰 𝗦𝗮𝘁𝘂𝗿𝗱𝗮𝘆𝘀’ sessions tend to be more of a celebration and with a party atmosphere. “Enlightened Electro, World Beat, Deep House and Downtempo Bliss, plus a few surprises slipped in for good measure! Ecstatic Music Journeys for Conscious Movement and Sacred Celebration.”
In our ‘𝗘𝗰𝘀𝘁𝗮𝘁𝗶𝗰 𝗦𝘂𝗻𝗱𝗮𝘆𝘀‘ sessions, the musical focus will be more of a World/Medicine music, Afro-House & a Tribal Flow vibe. You’re invited to explore “movement as meditation” .
ABOUT THE MUSIC:
“Enlightened Electro, World Beat, Deep House and Downtempo Bliss, plus a few surprises slipped in for good measure! Ecstatic Music Journeys for Conscious Movement and Sacred Celebration.”
WHY CACAO & ECSTATIC DANCE?
Cacao is the ultimate heart opener, it will give you energy, revitalise your BodyMind inviting you to express, release & unleash your creativity during the dance! ◈ Join us to explore Cacao + Ecstatic Dance as a potent synthesis for Transformation!Release what no longer serves you, and invite in what you want more of in your life!
ABOUT DJ AND FACILITATOR:
◈ Sessions are facilitated and DJed by Seth Newman, Seth is the pioneer of Ecstatic Dance in the UK, who started Ecstatic Dance journeys with his band Urubu & Ecstatic Dance London in 2009 and has been running conscious dance classes & events as well as various body-mind integration classes and workshops for many years.
◈ His inspiration for these classes come from many sources including Humanistic & Body Psychotherapy, the Human Potential Movement, 5 Rhythms, Active meditations and from the teachings of the Indian Mystic Osho whom he grew up with in India in the 1970s. Seth brings a wealth of experience holding heart-centered spaces.
𝗦𝗘𝗘 𝗢𝗨𝗥 𝗙𝗨𝗟𝗟 𝗘𝗩𝗘𝗡𝗧𝗦 𝗖𝗔𝗟𝗘𝗡𝗗𝗔𝗥: https://www.ecstaticdancelondon.com/events
INSTAGRAM: @urubu_school_of_transformation, @ecstaticdance_london #ecstaticdancelondon #youareyoubeyou
FACEBOOK GROUPS: URUBU – Ecstatic Dance London, Ecstatic Dance London
ECSTATIC DANCE PRACTICE SPECIFICS:
Warm-up: 15 minutes stretch, move/dance and reflect on the intention for the dance to a gentle sound wave.
The Practice: 90 minutes of freestyle dancing to a large sound wave featuring Live DJ set with our resident DJ Seth Newman. Some guidance & facilitation will be provided. And then we will let the music, the community and our own inner space direct our steps, our movements, our expression, our journey.
Relaxation : 15 minutes of Deep Relaxation.
“Our bodies instinctively know what feels good or bad, right or wrong. However, often our heads get in the way. Ecstatic Dance is about finding our way through to what feels good. How can we use dance to consciously transform towards finding joy, without denying our anger or sadness? Ask yourself: what’s my body feeling in this moment? Does it feel good moving this way, or that? Does it feel nourishing to dance with another, or dance solo? Where do I most feel connected with Self? Let your body lead the way.” ~ Abigail Harris
1. No talking during the dance (if you wish to talk to, you are welcome to chat before/after dance outside the building). When we dance without the chitchat, something alchemical can happen on the dancefloor. A unified field of Being emerges and we feel both wild and free, contained within ourselves And connected to something much, much greater than our individual selves.
2. Drug-Free, Smoke-Free, Alcohol-Free environment
3. No photos or videos, Mobile phones muted and out of sight
4. Care/Awareness for the co-created space and each other
5. Move your body however you wish
6. No spectating. Stay connected to your own body, sensations, emotions, and feelings. Ecstatic Dance is about you and your relationship to the Dance. Dancers feel uncomfortable when being spectated at. Come prepared to Dance yourself free from inhibitions without giving a F@ck what others think.
7. You can dance alone, or with as many partners as (you) like to join. (If you’d rather not dance with someone, thank them for the offer by placing your hands in prayer position at your heart – Namaste.)

domain: artistic


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While an injured person is not entitled to compensation for pre-existing conditions, he or she may be entitled if a pre-existing condition was worsened as a result of the accident. For the injured party, how forthcoming he or she is regarding any pre-existing conditions or injuries may greatly impact how the case is handled. Omission or concealment of such information could lessen the credibility of a claim.
Transparency in a case like this can either benefit or hurt a plaintiff’s case. With the “egg-shell plaintiff” theory, the law dictates that a defendant must take a plaintiff as found. For example, if you injure someone with your car who happens to have weak bones, your liability is not reduced simply because the person is predisposed to greater injury. A doctor would be required to substantiate the claim that the injured party’s pre-existing condition was worsened and necessitates new treatment related to the recent injury.
Conversely, a pre-existing condition may hurt a plaintiff’s case and may lessen the worth of a case if there are questions regarding treatment. For example, if a plaintiff already suffers from back problems and regularly sees a chiropractor, then gets into a car crash and continues to see a chiropractor for the worsened pain, the legitimacy of that claim may be doubted. In any case, insurance companies do their best to limit what they pay out and will try to take advantage of a pre-existing condition to lessen compensation.
Fieger Law is Michigan’s top law firm specializing in personal injury cases and will fight for your right to compensation. We have helped victims of construction site accidents, slip and fall accidents, workplace accidents, and have won over 165 verdicts and settlements of $1 million or more.

domain: law


A wide variety of laser marking machines, we often do not know which is more suitable for their own work, the various types of laser marking machine performance is not very well understood, in this case, people tend to choose the imported laser marking machine, always think that the export is good, but in the end is not so? We are now looking at the laser marking machine in the end has what advantages.
1. Strive to optimize the laser beam quality of semiconductor lasers. The beam quality can be optimized in the following ways. The first method is: to tune the laser to the school, such as to try to ensure that the full-and semi-mirror and the two-end of the YAG rod is parallel, completely parallel, so the laser is the most optimized laser. The second is that the semiconductor laser cavity in the whole mirror can also become convex, which is conducive to the optimization of spot. Once again, the total length of the optical cavity is extended, so that the quality of the spot will be better. Finally, we can combine the suitable small Kong Guanglan with the light path to optimize the beam quality.
2, increase the power of semiconductor lasers, such as switching 75W semiconductor module. The increase of laser power can achieve a multiplier effect.
3, the semiconductor laser linear output segment in advance, to achieve this goal can be changed by the output of the mirror, such as 20% or 25% output rate.
4, the replacement of better Q-switch performance, Q-switched on the pulse response speed of the drive has a great relationship, a good quality Q switch can increase the energy of the laser into a thousand times, so that each pulse of the laser has a few coke energy, so that it will be marked with depth.


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I am going to by a Porche Cayman right now. I crossed the 50K profit today, and told myself when I make 50 grand in AAPL I am buying a Porche. Thank you AAPL!
Porsche. I have two. A 1962 Speedster and a 2006 Carrera Turbo. Plus several vintage racing motorcycles and a nice house on the lake. All paid for by aapl. Thank you Steve Jobs, you're the man.
Z06 Corvette for 30 K more??
Two more years I can buy a submarine in my swimming pool.And buy a fucking Porche for my maid.Happy trading.
You can buy mine. Mint!http://sandiego.craigslist.org/car/374302813.html
I'm gonna get the dealership. I'll cut you a deal on oil changes.
Buy a HOUSE too!!! :))))
That 50k of AAPL stock is going to be worth a Ferrari in two years ;)
meteor grey or black, black interior. and get the S, if you can't afford it, wait until monday ;-)


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There’s nothing quite like organizing your first official family vacation together. It seems so easy to do at first, and you assume everything will go perfectly! All it takes is the first five minutes in the airplane, however, to start realizing that traveling with kids isn’t quite as picturesque as you may have imagined.
In order to keep your sanity then you should know the right tips to make the hard parts a bit easier. Take a look at some of the best ways to save money and your peace of mind when planning a vacation with children.
Consider Renting a Car
If you’re flying into your location where you plan on taking a trip, then it’s logical to think that you’re obviously not going to be able to bring your car. Last we checked cars didn’t fit in the bottom of airplanes.
Once you arrive, you’ll need to be able to get around. Let’s face it, having to wait around for public transportation with a grumpy child isn’t anyone’s idea of a relaxing time.
Therefore, you may want to consider renting a car when you arrive. Having a car at your disposal to get around is worth every penny when you’re traveling with kids. A car rental, unlike cabs, provides your child with the security of a car seat, which is reassuring should you ever get into an accident.
Depending on where you go, you’ll likely end up spending less overall on a rental than if you were to take cabs everywhere.
Consider Renting a House
Renting a room in a hotel with your family isn’t just more expensive, but it’s way too small of a space with kids. In order to be able to enjoy your trip, it’s essential that you’re able to put the kids to bed at the end of the day so that you can stay up and have some peace and quiet on your holiday. You don’t have that option of staying up and making any amount of noise after the kids are asleep you’re all staying in the same room!
Leasing a house or getting an Airbnb is an incredibly convenient and cost-effective form of accommodation with kids. If you’re traveling with another family, you can easily find great deals which are a fraction of the total cost since you’re all splitting the amount.
You will also save money on eating out. Since your leased home will have a kitchen, you’ll be able to cook in a few nights rather than paying top dollar in a restaurant.
Do Your Research
Instead of arriving at your destination totally clueless, it’s best to have done your research ahead of time. Try to get an idea of the lay of the land of your vacation destination from the best restaurants to eat at to where the local parks are.