text:
Miroslav Gantar,1 Sivanesan Dhandayuthapani,2 and Appu Rathinavelu2
1Department of Biological Sciences, Florida International University, Miami, Florida, USA.
2Rumbaugh Goodwin Institute for Cancer Research, Nova Southeastern University, Plantation, Florida, USA.
C-phycocyanin (C-PC) from Spirulina has been previously shown to have anticancer properties. Here, we report on anticancer activity of C-PC that was isolated from the novel cyanobacterium Limnothrix
sp. 37-2-1. C-PC from this organism exhibited anticancer properties in our in vitro systems; however, the required doses were well above the range of anticancer drugs normally used. Therefore, we conducted several experiments to test whether lower-than-usual doses of the anticancer drug topotecan (TPT) can offer the same level of cytotoxic effects as normal doses when combined with C-PC. For this purpose, cytotoxicities of C-PC and TPT were tested using the LNCaP (prostate cancer) cells. We found that when only 10% of a typical dose of TPT was combined with C-PC, the cancer cells were killed at a higher rate than when TPT was used alone at full dose. Similarly, we were also able to detect an increased level of radical oxygen species (ROS) generation as well as an increase in activities of caspase-9 and caspase-3 when these two compounds were used in combination. Taken together, our findings suggest that combining C-PC from Limnothrixsp. with the lower dose of TPT can induce apoptosis through generation of ROS and activation of caspases. In that respect, we suggest that C-PC can potentially improve the efficacy of the currently available anticancer drug, and therefore diminish its harsh side effects in the patient.
KEY WORDS: anticancer, caspases, cyanobacteria, DNA fragmentation, Limnothrix, Spirulina
Chemotherapy currently represents the most often used modality in cancer treatment. Most of the currently used chemotherapeutic drugs have their origin from plants, microbes, or marine organisms. However, the number of antineoplastic agents currently available to oncologists is quite limited, and there is a great need to identify either new antineoplastic drugs or some agents, preferentially from food or food supplements that will enhance and improve the ef- ficacy of currently available drugs. In that respect, cyanobacteria have been screened for, and many have been identified as a potential novel source of anticancer drugs.1,2 In 1980s, the cyanobacterium (or blue-green alga) Spirulina started to be marketed as a health food with numerous claims about the beneficial effects on human health, among others as a potential source of novel anticancer drugs.3 Many of these medicinal properties of Spirulina are now associated with one particular compound, C-phycocyanin (C-PC). C-PC is a blue-colored photosynthetic accessory pigment that absorbs light at 620 nm and emits fluorescence at about 560 nm. It is a protein containing two subunits, molecular weight of which depends on the organism from which it was isolated, and ranges between 50 and 230 kDa.4 Subunit a carries one and subunit b has two tetrapyrol chromophores.5 One of the first reports on beneficial effect of phycocyanin cites the Japanese patent #58-65216, according to which this blue pigment from Spirulina significantly increased the survival rates of mice that had been injected with liver tumor cells.6,7 It has been suggested that stimulation of the immune system by phycocyanin was a mechanism that inhibited the growth of tumor cells. Liu et al.8 also reported on antineoplastic activity of phycocyanin isolated from Spirulina. They found that this pigment significantly inhibited the growth of human leukemia K562 cells through mechanisms other than apoptosis. However, induced apoptosis was described as a mechanism of phycocyanin action by a number of authors. Reddy et al.9 used mouse macrophage cells, which were treated with lipopolysaccharide (LPS) to express high levels of COX-2, overexpression of which is known to be responsible for downregulation of apoptosis. When these cells were exposed to C-PC, it induced apoptosis in a dose-dependent manner. A different mechanism of apoptosis induction was described in AK5 tumor cells. Pardhasaradhi et al.10 explained the C-PC induction of apoptosis by downregulating of Bcl-2 (a known inhibitor of apoptosis) and by generation of radical oxygen species (ROS). This finding was also confirmed with the human chronic myeloid leukemia cell line K562.11 At present, it is not known whether the whole C-PC molecule is required for the anticancer activity. Nevertheless, it was shown that the b-subunit of C-PC that was cloned in Escherichia coli had the same or even more potent power of apoptotic induction when tested on four different cancer cell lines.12 Cells of the treated cancer cell lines underwent apoptosis with an increase in caspase-3 and caspase-8 activities with an arrest at the G0/G1 phase. Caspase-dependant apoptosis was also confirmed in C-PC–treated HeLa cells.13 In this work, we used C-PC from our novel cyanobacterial isolate Limnothrix sp. 37-2-1 to test its anticancer properties. We have shown that Limnothrix can be a better source for CPC than the traditionally-used Spirulina. 4 In this preliminary work, we have confirmed that C-PC from Limnothrix indeed had antiproliferative activity against a prostate cancer cell line (LNCaP). However, the required concentration of phycocyanin for anticancer activity was well above the range of anticancer drugs normally used. Therefore, we hypothesized that C-PC could be potentially used as an enhancer of existing anticancer drugs. Here, we are presenting data of in vitro experiments, which confirm our hypothesis.
MATERIALS AND METHODS
Phycocyanin isolation and purification
Phycocyanin was isolated from the novel strain of cyanobacterium Limnothirix sp. 37-2-1 by a procedure described elsewhere.4 Briefly, the cyanobacterium was grown in a 30-L photobioreactor; the biomass was harvested and extracted. The pigment was purified by fractional precipitation of the cell crude extract by ammonium sulfate and treated with activated carbon and chitosan. The pigment was desalted and concentrated by tangential flow filtration. The purity of C-PC was checked by sodium dodecyl sulfate–polyacrylamide gel electrophoresis and by calculating the ratio of the absorbencies at 620 and 280 nm. Only those preparations of phycocyanin that had the 620/280 ratio greater than 4.0 were used for further experiments. The purified phycocyanin was freeze-dried and kept in a refrigerator until use.
Cell line and reagents
The prostate cancer (LNCaP) cell line was a generous gift from Dr. Thomas Powell (Cleveland Clinic Foundation, Cleveland, OH, USA). The RPMI-1640 growth medium, amphotericin-B, L-glutamine, and antibiotic–antimycotic solution containing penicillin and streptomycin were obtained from Atlanta Biologicals (Lawrenceville, GA, USA). The fetal bovine serum was purchased from Hyclone (Logan, Ut, USA), and topotecan (TPT) was purchased from Sigma Chemical Co. (St. Louis, MO, USA). The substrates and inhibitors of caspase-9 and caspase-3 were purchased from Enzo Life Sciences AG (Lausen, Switzerland). The Qiagen DNeasy kit (Qiagen, Valencia, CA, USA) was used for the extraction of the DNA to determine the DNA fragmentation. All other chemicals used in our research were of research grade purchased through standard suppliers.
Cell culture and treatment
The LNCaP cells were grown as a complete monolayer in RPMI-1640 growth medium supplemented with 10% fetal bovine serum, 10,000 U/mL of penicillin, 10,000μg/mL of streptomycin, 1% (+)-L-glutamine, and 1% amphotericin-B. The cells were grown at 37℃ under a humidified air/CO2 (19:1) atmosphere. All experiments were conducted using cells in the logarithmic phase. In each well of a six-well plate,～1 ×106 cells per well were grown for 24 h.
Determination of cell death and ROS
To determine the cytotoxic effect of C-PC and TPT, the monolayer culture of LNCaP cells was used. The cells were incubated in the presence of C-PC (250 and 500μg/mL) and TPT (1 and 10μM), individually and in combination. All incubations were carried out for 16 h. After the incubation period, cell death was determined by using trypan blue dye exclusion test. To determine the levels of ROS generation, the cells cultured in six-well plate were incubated with different concentrations of C-PC and TPT as described above. At the end of incubation period, levels of ROS generated were measured using the nitro blue tetrazolium (NBT) chloride reduction assay.
Assay of caspase-9 and caspase-3 activities
To determine the activity of caspase-9 and caspase-3, LNCaP cells were treated with different concentrations of the C-PC (250μg/mL) and TPT (1 and 10μM). After the incubation time, cells were harvested, washed, and resuspended in a cell lysis buffer and kept on ice for 10 min. The cell lysate was centrifuged at 1400g for 5 min; the supernatant was assayed for protein concentration and further diluted with the lysis buffer to adjust the protein concentration. Equal amounts of protein from each sample were added to 96-well plates and mixed with the 2 · reaction buffer (100mM HEPES [pH 7.4], 200mM NaCl, 20mM dithiotheritol,2mM ethylenediaminetetraacetic acid, and 0.2% chaps) and 2mM of the respective substrates acetylLeu-Glu-His-Asp-p-nitroaniline (Ac-LEHD-pNA) and acetylAsp-Glu-Val-Asp-p-nitroaniline (Ac-DEVD-pNA). For measuring the specific activity of caspase-9 and caspase-3, the respective inhibitors Ac-LEHD-CHO and Ac-DEVDCHO were used. Release of the cleaved p-nitroanilide from the tetrapeptide substrates was measured using the 96-well microplate reader at 405 nm.
DNA fragmentation assay
DNA fragmentation assay was performed by using a monolayer of LNCaP cells that were grown in T-25 culture flasks and incubated with different concentrations of C-PC and TPT, individually and in combination. After incubation, the cells were harvested and washed with phosphatebuffered saline (PBS). Cells were resuspended in 200μL of PBS, and 20μL of proteinase K was added. The DNA was extracted using the Qiagen DNeasy Kit, following the manufacturer’s protocol. The samples were subjected to
electrophoresis at 80 V for 2 h in a 1.5% agarose gel containing 5μL of ethidium bromide. Separated DNA fragments were viewed with an UVP image analyzer.
The data presented here represent mean – standard deviation values from at least four separate experiments. Statistical analyses were performed using one-way analysis of variance, followed by Student–Newman–Keuls multiple comparison tests. Values of P<.05 were considered as significant and presented in results.
Treatment of LNCaP cells with C-PC and TPT resulted in a significant inhibition of cell growth (Fig. 1). By incubating the cells in the presence of C-PC at two applied concentrations (250 and 500μg/mL), the survival rate of the cells was between 65% and 70%. However, this effect was more pronounced when C-PC was combined with TPT. When LNCaP cells were treated with 10μM of TPT alone, 62% cells were killed in 18 h, whereas at the concentration of 1μM, TPT caused death in only 3–4% cells within the same time frame. Therefore, to test our hypothesis that C-PC enhances the activity of the anticancer drug, we have chosen 1μM concentration of TPT for combination treatments. When 1μM of TPT was combined with 500μg/mL of C-PC, 80% of cells were killed due to the additive effect. Similarly, the treatment of LNCaP cells with C-PC and TPT showed a significant increase in the rate of ROS generation (Fig. 2). The highest ROS production was obtained when the cells were incubated with a combination of C-PC (500μg/L) and TPT (1μM).
The inhibition of cell viability could have resulted from the induction of apoptosis. To confirm this, the cells treated with C-PC and TPT were subjected to DNA fragmentation analysis. Figure 3 clearly shows internucleosomal DNA fragmentation of cells treated with different concentrations of C-PC and TPT. The DNA fragmentation was the most pronounced when the C-PC–TPT combined treatment was applied.
To identify whether caspases were involved in C-PC– induced apoptosis, the C-PC– and TPT-treated cell lysates were analyzed for the caspase-3 and caspase-9 activities by using colorimetric assay. As expected, caspase-3 and caspase-9 (Fig. 4) activities in C-PC– and TPT-treated cells were found increased when compared to untreated control cells. Our data suggest that C-PC–induced apoptosis is characterized by the caspase-dependent pathway.
The use of natural products to inhibit carcinogenesis and to treat cancer is an important and rapidly growing field of cancer research. There has recently been a surge of interest in diverse bioresources as potential novel sources of anticancer compounds. One of these includes cyanobacteria (blue-green algae), which were shown to produce a number of anticancer compounds such as scytophycins,14 tolyporphin,15 apratoxin A and antillatoxin B,16,17 malevamide D, curacin D and symplostatin 3,18 lyngbouilloside,19 and cryptophycin.20 However, in addition to these toxic compounds, cyanobacteria produce a blue pigment C-PC, which is a nontoxic compound,21 yet it has anticancer properties.11,22 This compound is readily available as a component of Spirulina biomass, which is sold in health food stores worldwide.
In this article, for the first time, we present our preliminary data on antineoplastic activity of C-PC that was isolated from the novel cyanobacterial strain Limnothrix sp. 37-2-1, and also we showed that when combined with the standard chemotherapeutic agent TPT, C-PC enhanced the cancer cell death. Specifically, when only 10% of typical dose of TPT was combined with 500 μg/L of phycocyanin (Fig. 1), the cancer cells were killed at a much higher rate than when TPT and phycocyanin were used separately.
Accumulative evidence suggests that defects in the process of apoptosis may be closely associated with carcinogenesis, and that many cancer cells have defective machinery for self-destruction.23 Apoptosis is a specific mode of cell death recognized by a characteristic pattern of morphological, biochemical, and molecular changes. Most of the existing cancer drugs target apoptosis. Our finding that C-PC affects the LNCaP cells by inducing apoptosis is confirmation of previous reports in which C-PC used was obtained from Spirulina. 9,11 In our experiments, apoptosis was confirmed by DNA fragmentation (Fig. 3), shown both when C-PC and TPT were used individually and in combination. One of the probable causes of cell death during CPC–anticancer drug combined treatment is induction of ROS production, leading to caspase-3 activation and DNA fragmentation. Our study confirms earlier report10 that C-PC indeed induces ROS-dependent apoptosis. The highest level of ROS production was observed when the LNCaP cells were treated with the combination of TPT and C-PC. Furthermore, C-PC treatment increased the activities of both caspase-3 and caspase-9, which are the most important proteases found in apoptotic cells.23 Further in vivo and in vitro molecular studies will be needed to identify the appropriate application conditions and doses of C-PC in the treatment process.
Combining the known anticancer drugs with natural products for the treatment of cancer patients is apparently a new avenue in cancer research. This kind of approach and its benefits have been reported recently by He et al., 24 who showed that resveratrol, a unique polyphenol produced by plants, potentiates the growth inhibitory effect of rapamycin. Whether used in a combined treatment or in the form of a hybrid molecule,25 this approach deserves further research.
In conclusion, the results suggest that the use of the CPC–TPT combination can reduce the effective dose of TPT, and still maintain its efficacy in inducing significant apoptotic cell death in LNCaP cells. Based on these preliminary data, it is suggested that the C-PC–TPT combination may have a therapeutic value.
The authors would like to thank the Royal Dames of Cancer Research Inc. (Ft. Lauderdale, FL, USA) for their generous financial support. AUTHOR DISCLOSURE STATEMENT No competing financial interests exist with this work.
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2. Patterson GML, Larsen LK, Moore RE: Bioactive natural products from blue-green algae. J Phycol 1994;6:151–157.
3. Gantar M, Svircev Z: Microalgae and Cyanobacteria: food for thought. J Phycol 2008;44:260–268.
4. Gantar M, Simovic´ D, Djilas S, Gonzalez WW, Miksovska J: Isolation, characterization and antioxidative activity of C-phycocyanin from Limnothrix sp. strain 37-2-1. J Biotechnol 2012;159:21–26.
5. Glazer AN, Fang S: Formation of hybrid proteins from the a and b subunits phycocyanin of unicellular and filamentous blue-green algae. J Biol Chem 1973;248:663–671.
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7. Dianippon Ink and Chemicals (DIC): Antitumoral agents containing phycobillin. Japanese Patent #58-65216, inventors: N. Lijima, N. Fujii and H. Shimamatsu; assignees: Dainippon Ink and Chemical Tokyo Stress Foundation. April 18, 1983, pp. 6.
8. Liu Y, Xu L, Cheng N, Lin L, Zhang C: Inhibitory effect of phycocyanin from Spirulina platensis on the growth of human leukemia K562 cells. J Appl Phycol 2000;12:125–130.
9. Reddy MC, Subhashini J, Mahipal SVK, Bhat VB, Reddy PS, Kiranmai G, Madyastha KM, Reddanna P: C-phycocyanin, a selective cyclooxygenase-2 inhibitor, induces apoptosis in lipopolysaccharide-stimulated RAW 264.7 macrophages, Biochem Biophys Res Commun 2003;304:385–392.
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11. Subhashini J, Mahipal SVK, Reddy MC, Reddy MM, Rachamallu A, Reddanna P: Molecular mechanisms in C-phycocyanin induced apoptosis in human chronic myeloid leukemia cell lineK562. Biochem Pharmacol 2004;68:453–462.
12. Wang H, Liu Y, Gao X, Carter CL, Liu Z-RL: The recombinant b subunit of C-phycocyanin inhibits cell proliferation and induces apoptosis. Cancer Lett 2007;18:150–158.
13. Li B, Gao MH, Zhang XC, Chu XM: Molecular immune mechanism of C-phycocyanin from Spirulina platensis induced apoptosis in HeLa cells in vitro. Biotechnol Appl Biochem 2006;43:155–164.
14. Smith CD, Carmeli S, Moore RE, Paterson GM: Scytophycins, novel microfilament-depolymerizing agents which circumvent Pglycoprotein-mediated multidrug resistance. Cancer Res 1993; 53:1342–1347.
15. Smith CD, Prinsep MR, Caplan FR, Moore RE, Patterson GM: Reversal of multiple drug resistance by tolyporphin, a novel cyanobacterial natural product. Oncol Res 1994;6:211–218.
16. Nogle LM, Okino T, Gerwick WH: Antillatoxin B, a neurotoxic lipopeptide form the marine cyanobacterium Lyngbya majuscula. J Nat Prod 2001;64:983–985.
17. Leusch H, Yoshida WY, Moore RE, Paul VJ, Corbett TH: Total structure determination of apratoxin A, a potent novel cytotoxin from the marine cyanobacterium Lyngbya majuscula. J Am Chem Soc 2001;123:5418–5423.
18. Leusch H, Yoshida WY, Moore RE, Paul VJ, Mooberry SL, Corbett TH: Symplostatin-3, a new dolastatin 10 analogue from the marine cyanobacterium Symploca sp. VP452. J Nat Prod 2002;65:16–20.
19. Tan LT, Marguez BL, Gerwick WH: Lyngbouilloside, a novel glycosidic macrolide from the marine cyanobacterium Lyngbya bouillonii. J Nat Prod 2002;65:925–928.
20. Trimurtulu G, Ohtani I, Patterson GML, et al.: Total structures of cryptophycins, potent antitumor depsipeptides from the bluegreen alga Nostoc sp. strain GSV 224. J Am Chem Soc 1994;116:4729–4737.
21. Akhilender Naidu K, Sarada R, Manoj G, et al.: Toxicity assessment of phycocyanin—a blue colorant from blue green alga Spirulina platensis. Food Biotechnol 1999;13:51–66.
22. Nishanth RP, Ramakrishna BS, Jyotsna RG, et al.: C-phycocyanin inhibits MDR1 through reactive oxygen species and cyclooxygenase-2 mediated pathways in human hepatocellular carcinoma cell line. Eur J Pharmacol 2010;649:74–83.
23. Yano H, Mizoguchi A, Fukuda K, Haramaki M, Ogasawara S, Momosaki S, et al.: The herbal medicine sho-saiko-to inhibits proliferation of cancer cell lines by inducing apoptosis and arrest at the G0/G1 phase. Cancer Res 1994;54:448–454.
24. He X, Wang Y, Zhu J, Orloff M, Eng C: Resveratrol enhances the anti-tumor activity of the mTOR inhibitor rapamycin in multiple breast cancer cell lines mainly by suppressing rapamycin-induced AKT signaling. Cancer Lett 2011;301: 168–176.
25. Decker M: Hybrid molecules incorporating natural products: applications in cancer therapy, neurodegenerative disorders and beyond. Curr Med Chem 2011;18:1464–1475.

domain: chemistry


text:
A Bad Rap
Presents the result of a study on the attitude of white Americans towards black american rap music. Differences in responses of control and experimental group; Implications of the study.
By Lisa Tolin published July 1, 1997 - last reviewed on June 9, 2016
Thanks to songs like "Cop Killer," rap music may have developed asinister reputation among white Americans. When white college students were shown song lyrics describing a man who kills a police officer--but not told the performer's name or the genre of music--84 percent assumed that the words were from a rap song, and most deemed the work more offensive than "Cop Killer" itself. In fact, the lyrics came from I "Bad Man's Blunder," a 1950s folk song by the all white Kingston Trio.
Next, one group of students was told that these were raP lyrics and a second was informed that they came from a folk song. The "rap" group, it fumed out, reported the lyrics to be much more offensive and threatening than did the "folk" group.
The results not only indicate resistance to rap but may also signal a deeper cultural bias, according to Indiana University psychologist Carrie B. Fried, Ph.D., who conducted the study. In a second experiment, subjects were given a picture of the artist in addition to the lyrics. Those shown a young black man found the words offensive as often as the group told the lyrics came from a rap song. According to Fried, this finding backs research showing that actions are seen as more violent and aggressive if the perpetrator is black rather than white.

domain: sociology


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Didn't even get the slightest bit interesting until about chapter 30 something. I think it missed out on so many details that could have really been interesting and telling of the time but instead we got a lot of bible passages.
so glad this saint's story is not lost in the obscurity of history. Metaxas presents the story masterfully. excellent narration as well.
Excellent biography of Dietrich Bonhoeffer. I felt that I got to know the man, his family background, his thoughts, theology, his struggles, and passions. The reader did an outstanding job reading the biography. The book and performance kept me engrossed in it to the very end.
I was initially concerned about enduring over 22 hours of listening to a book but that quickly evaporated once I started. Probably the level of details contained in the book - with innumerous letters and conversations (superb research by Eric Metaxas...) is what probably impressed me the most, making the listening enjoyable and interesting.
Bonhoeffer himself, and that had to be since it is a biography. He seemed to be very wealthy, or at least his family was, certainly well connected in the upper levels of the German society (why not say aristocracy). Nevertheless, he lived his life knowing the Cost of Discipleship.
First time listening Hillgartner and I was very pleased (will look into other books). The long listening was not boring considering I did 2 stretches of 5 hours each in 2 days while driving (that says something...) plus other commute driving days.
The whole story is captivating but his perspective of Christianity in America (the differences between NY and the South) vs. Christianity in Europe was quite interesting.
The only thing I would point out is that the author could not describe the horrors of the war the way it must have been (unless we have a different perspective of the facts - at least the way we know it). Bonhoeffer travelled back and forth throughout Europe (even to US) during periods of extreme turmoil and the impression I had was that it wasn't such a problem to do that.
An inspirational story and picture of history that might surprise you. A Christian's resistance to Hitler
An incredible story paired with Eloquent writing and a wonderful voice actor makes this a moving experience to listen to. Enjoyed it thoroughly, a story of a life everyone should know.
Good story, great narration. I chose this on a whim based on the description for the historical aspects. I did find those aspects to be very interesting, but I also found myself struggling through the sheer volume of theology. I guess I should have been more prepared for that - after all, the man was a theologian!
A different look into the Third Reich and the legacy of a brilliant, humble, selfless servant of Christ. What a difference one life can make. The author was also quite accurate in recalling the circumstances that allowed Hitler to rise to power.

domain: library


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algo/tests/Makefile: .bak files are the old files!
Never commit in a hurry! The previous commit (see 8496cbb0) indicated a suffix for the backup files (necessary with POSIX sed). Then we were overwriting the tap files with the bak ones. This was totally stupid as we were overwriting the correct files with the old ones… This is now fixed we just delete the backup files as we don't really need them (we just specify the option to ensure the compatibility between POSIX and GNU sed).


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The town Kiruna itself exists as a result of the mining industry, but instead of trying to repair the crack threatening to swallow the town whole, the government is suggesting a move of the entire city, approximately 3 kilometers east. This plan has been in the works since 2010, but only recently has it come into international media.
Artic #town Kiruna is on the move – at a cost of £1 billion – to avoid being swallowed by the mine on which its foundations and fortunes are built @HuffPostUK https://t.co/kAqe6cVoZf #urbandesign pic.twitter.com/IEBAIL2BU1
— Urban Design Group (@UDGUrbanUpdate) December 21, 2018
Even in Sweden much remains unknown about the move. Back in 2016, major controversy occurred as the Swedish population seemed more informed about the remodelling of Slussen, an area of central Stockholm than of the situation in Kiruna, up in the very north of the country.
Many people have accused the government of a lack of care of the more northern and rural areas of the country in favour of the ever growing capital. This comes after TV whether forecasts actively descaled the largest and northernmost lands of the country, Norrland, in order to show the southernmost parts of the country in more detail. Being from Norrland myself, I have seen the effects of this rejection of the north in everyday life.While we may be the least populated part of the country, it is also home to the largest population of working class people, and the main production of energy through its mines, hydropower stations and solar energy plants. Not to mention it’s beautiful forests providing the country with a continuous flow of fresh air. Simply put, we are keeping the southern parts of the country alive, and what do we get in return?
The oldest houses are being transported on trailers but most of the community will be destroyed and rebuilt in what is to be called the new Kiruna City Center. All this in order for the mining company LK AB to be able to continue their production. The first house to be moved was one from 1899, almost as old as Kiruna itself. While the initial building began its journey east on the 24th of may 2017, the new Kiruna is not expected to be complete until 2035.
So where does this leave the inhabitants of the town?
Well, as you might be able to imagine, a large part of the population is furious. Kiruna is a beloved city with a thriving community, and not to mention one of those cities where people never really move away, even as generations come and go.
These people will in short not only loose their housing, their employment and their everyday routine, but they’re loosing an essential part of their childhood as well. Some of the costs of innocent people’s drastic uptake will be subsidised by the government as well as the mining company at large, but this will still not fully cover the expenses of building a completely new home, 3 KM away.
The North of Sweden offers some absolutely astonishing sights, including incredible ski slopes, hiking tracks and not to mention the Northern Lights. These attractions, and many more, provide the country with a huge amount of money through it’s tourism, and while Kiruna may not be the number one sightseeing location, the economy sustained in the community is what helps keep the wildlife of rural Sweden clean, and most importantly, free.
This complete disregard of the citizens of Kiruna is a complete disgrace and if the government doesn’t start giving the North the attention it deserves, they will surely pay the price.

domain: geography


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I’ve heard that CBD May Help with COVID-19 Symptoms, is this true?
People swear by CBD (cannabidiol) and believe it can help in a whole slew of conditions beyond just sleep, pain and anxiety. In any case it’s important for your mental wellbeing, physical health and the strength of the immune system to get proper nutrition, exercise and manage their stress in addition to using for example CBD.
But now in addition to the lack of clarity coming from the media and government you also hear from friends and Facebook posts that CBD can help prevent and even cure or lessen the symptoms of Coronavirus. Is this true?
Is this true that CBD may help with Covid-19 Symptoms and infection?
The honest answer is we do not know. While there have been studies done that under very specific conditions in cell culture or in mice – that does not mean that those conditions are valid or indicative to COVID 19 in humans.
There are reason why CBD could be effective in battling the disease but these reasons are mainly theoretical. As Forbes recently stated: “many are waiting and hoping for treatments to be developed that might treat, cure or prevent the potentially deadly disease. In a surprising turn of events, cannabis is on the list of potential treatments.”
Science is aware of the anti-inflammatory function of CBD and so many postulate that due to the almost ubiquitous distribution of endocannabinoid system in the body – it may help in reducing the severe inflammatory response to COVID 19 which is a major contributing factor in a large percentage of hospitalizations, need for intubation and deaths.
An area of potential benefit is for patients who are the most severely ill from this novel Coronavirus – particularly those with more serious levels of lung inflammation. This is due to the well documented anti-inflammatory effects and the reduction of cytokines which have a pro-inflammatory effect which can otherwise cause a ‘cytokine storm’ and a massive inflammatory response in the lungs – known as ARDS – which worsens the patients already dire situation.
In July 2020 researchers from the Augusta University in Georgia published a study whereby mice suffering from ARDS and a severe cytokine storm and who were having trouble breathing were given CBD. The authors of the study state that after treatment with CBD “These symptoms were totally or partially reversed and returned to the level and condition of the normal after treatment with CBD.”
In addition to an increase in the infection fighting white blood cell count in the mice after dosed with CBD – additionally different markers that are correlated with cytokine storms were measured. This can help in determining the potential pathways through which CBD may be affecting the inflammation and lung damage.
An important marker known as Interleukin 6 – or IL-6 for short – was most drastically reduced though other markers did also. The authors further explained that after the induction of the cytokine storm when the markers rose – “CBD treatment reversed all these inflammatory indices and partially re-established homeostasis”. (Homeostasis is defined as the normal setting and levels of these markers – an equilibrium the body keeps).
This study is both very promising and further supports the need for more studies on the use of cannabidiol in Coronavirus.
But if you have been or believe that you have been exposed to Coronavirus or if you have symptoms consistent with Covid-19 infection such as those below – that you quarantine and get tested. If possible consult a medical professional especially if symptoms are severe.
Covid-19 symptoms include:
- Fever or chills
- Shortness of breath or difficulty breathing
- Muscle or body aches
- New loss of taste or smell
- Sore throat
- Congestion or runny nose
- Nausea or vomiting
While there are theoretical reasons to believe that CBD May Help with COVID-19 Symptoms there are not any studies that show benefit and further studies are required before anyone can recommend CBD. Particularly so as many new therapies are emerging constantly which have proven to help reduce symptoms or death.

domain: biology


text:
Ewen Gallic : ewen.gallic[at]univ-amu.fr
Avner Seror : avner.seror[at]univ-amu.fr
How can individuals care about animals and, at the same time, eat meat? We design a survey study to explore this "meat paradox''. Survey participants (N= 3054) underestimate farm animal suffering, and underestimate it more (i.e., are less realistic) when they eat more meat. Building on the literature on cognitive dissonance, we develop a model in which individuals form self-serving beliefs in order to reduce the moral guilt associated with meat consumption. The model characterizes how individuals' beliefs about animal welfare and their attitude towards information are affected by the economic environment (e.g., price of meat, salience of animal welfare), and by individuals' preferences (e.g., taste for meat, moral cost of guilt). Several empirical observations are consistent with our model.
> Séminaire en ligne

domain: psychology


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Kim Hee-chan, who has built up his own filmography faithfully, regardless of genre such as drama and movie, unveiled his interview with a photographer in January of ‘ANA DRONE’ in Korea’s first drones monthly magazine.
Kim Hee-chan debuted in KBS ‘Producers’ in 2015, and is a newcomer who has taken a snowboard with an extraordinary performance. Since then, he has appeared in films such as ‘Glory Day’, ‘Cheese in the Trap’, ‘Luminous Office’ and ‘School 2017’. Especially, ‘School 2017’ is a villain with a longevity complex, showing impressive performances and proving his potential as a 20th-generation next-generation actor.
Kim Hee-chan, who has been challenging such a colorful character, has filmed the picture with the concept of becoming a virtual persona ‘persona’. Persona, poet, director, hero or wizard, personality personality that does not exist, and various various inner scenes of Kim Hee-chan were put in the picture.
From the loose all black look, Kim Hee-chan transferred to the persona and expressed his deep and deep sensitivity by digging the rough look of leather jacket and Mustang.
Kim Hee – chan showed a charm of the boy ‘s pure charm with his big and round eyes, but he turned to his intense eyes and emanated charisma. In the late afternoon, it gave a soft atmosphere to the languid sensibility of the late afternoon.
In an interview with the photographer, Kim Hee-chan said, “I want to be a long-loved and necessary actor. As we have done so far, 2019 is going to be a process toward this goal. It is a difficult goal, but I think it will be done if I do my best every moment. “Kim Hee-chan’s interest is gathered in 2019. Kim Hee-chan took the role of a taxpayer in the movie “Clowns”, which is scheduled to open in 2019, and settled down with Son Hyun-joo, Cho Jin-woong, Park Hee-soon and Ko Chang-seok.
On the other hand, Kim Hee-chan’s interview with the picture can be found in the January issue of ANA DRON, a monthly drones magazine.

domain: entertainment


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Israeli Government Plans To Be The World’s First Cashless Society
May 27, 2014 In: PFT Global Comments
Will Israel be the first cashless society on the entire planet? A committee chaired by Israeli Prime Minister Benjamin Netanyahu’s chief of staff has come up with a three phase plan to “all but do away with cash transactions in Israel”. Individuals and businesses would still be permitted to conduct cash transactions in small amounts (at least initially), but the eventual goal is to force Israeli citizens to conduct as much business as possible using electronic forms of payment. In fact, it has been reported that Israeli officials believe that “cash is bad” because it fuels the underground economy and allows people to avoid paying taxes. It is hoped that requiring most transactions to be conducted in cash will reduce crime and help balance the national budget. And once 98 or 99 percent of all transactions are cashless, it will not be difficult for the Israeli government (or any other government) to go the rest of the way and ban cash transactions altogether. But is a cashless society actually desirable? This is a question that people all over the world will have to start asking as governments increasingly restrict the use of cash.
Back in September, it was announced that the Israeli government had formed a committee to “examine ways to eliminate cash from the Israeli economy”…
- The government on Tuesday authorized establishment of a committee that will examine ways to eliminate cash from the Israeli economy – the better to prevent citizens from cheating on their taxes. The committee will be chaired by Harel Locker, director of the Prime Minister’s Office.
This committee had the full backing of Prime Minister Benjamin Netanyahu, and some of the goals of the committee included finding ways to increase tax revenue and prevent money laundering…
- Officials in the Prime Minister’s Office declared that “around the world, it is recognized that cash is a key element of the illegal economy and money laundering. It allows a wide gap between reported and actual incomes, with the corresponding effect on tax revenues.” By eliminating cash, the PMO said, “it will be possible to expand the tax base, and prevent money laundering.” The committee will study the issue from all its perspectives and make recommendations, the PMO said.
The committee has had quite a few months to examine these issues, and now they have come back with their recommendations. Just this week we learned that a three phase plan is being proposed…
- A special committee headed by Prime Minister Benjamin Netanyahu’s chief of staff, Harel Locker, has recommended a three-phase plan to all but do away with cash transactions in Israel.
The motivation for examining a cash-less economy is combatting money laundering and other tax-evasion tactics, thereby maximizing potential tax collection and greatly expanding the tax base. This is important considering the enormous strain put on Israel’s national budget by the army, healthcare system and other public services.
The committee estimated that the black market represents over 20 percent of Israel’s GDP, and cash is the facilitating factor. Cash enables tax evasion, money laundering and even financing terrorism.
So what do the specifics of the plan look like?
Well, there will be very strict limits on the use of cash for individuals and businesses, any violations will be considered criminal offenses, and all Israeli banks will be required to issue debit cards to all account holders.Continue Reading
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domain: economics


text:
Global Jet Fuel Additives Market 2017-2021
|発行||TechNavio (Infiniti Research Ltd.)||商品コード||348001|
|出版日||ページ情報||英文 74 Pages
|ジェット燃料添加剤の世界市場：2017年〜2021年 Global Jet Fuel Additives Market 2017-2021|
|出版日: 2017年07月05日||ページ情報: 英文 74 Pages||
世界のジェット燃料添加剤市場は、2017年から2021年の間、7.12%のCAGR (複合年間成長率) で拡大することが予測されています。
Jet fuel additives are used in the aviation industry to improve or enhance the performance of jet fuels. They are added in small quantities that are often measurable in parts per million. Typically, additives are derived from petroleum-based raw materials, and their chemistry and function are highly specialized. They are used in varying proportions in all petroleum-derived fuels. Additives that are used in the aviation industry should be approved by regulatory bodies such as the European Aviation Safety Agency and the Federal Aviation Administration (FAA) before they are commercially used.
Technavio's analysts forecast the global jet fuel additives market to grow at a CAGR of 7.12% during the period 2017-2021.
The report covers the present scenario and the growth prospects of the global jet fuel additives market for 2017-2021. To calculate the market size, the report presents a detailed picture of the market by way of study, synthesis, and summation of data from multiple sources.
The market is divided into the following segments based on geography:
Technavio's report, Global Jet Fuel Additives Market 2017-2021, has been prepared based on an in-depth market analysis with inputs from industry experts. The report covers the market landscape and its growth prospects over the coming years. The report also includes a discussion of the key vendors operating in this market.
You can request one free hour of our analyst's time when you purchase this market report. Details are provided within the report.


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Background: The indication for surgical resection of colorectal liver metastases should be guided by technical feasibility and expected prognostic benefit. The aim of the present study was to analyse the frequency and prognostic significance of lymph node involvement of the hepatoduodenal ligament in the resection of colorectal liver metastases.
Methods: A series of 126 prospectively documented patients who underwent hepatectomy for metastases of colorectal carcinoma was analysed. The prognostic factors of patients with complete resection (R0) of the metastases were studied by multivariate analysis.
Results: R0 resection was achieved in 94 per cent. The 30-day mortality rate was 2 per cent. In all patients, lymph nodes were excised from the hepatoduodenal ligament, and histological evaluation demonstrated tumour infiltration in 28 per cent of the patients. Multivariate analysis revealed nodal involvement of the hepatoduodenal ligament (P < 0.0001) and synchronous or metachronous appearance of liver metastases (P < 0.005) as independent prognostic factors. The 3- and 5-year survival rates were 3 and 0 per cent for lymph node-positive patients compared with 48 and 22 per cent respectively for the node-negative group.
Conclusion: Infiltration of lymph nodes in the hepatoduodenal ligament is the most important prognostic factor following R0 resection of colorectal liver metastases.

domain: medical


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By Emily Bray
Director and star of the delightful Short Term 12 return with an underwhelming epic of intergenerational family discord.
By David Jenkins
The director of Jurassic World skids off the rails in this bafflingly misguided kiddie revenge fantasia.
By Matt Bochenski
Michael Haneke’s latest is an attack on everything you think you know about cinema. It’s a brutal beating.
What are you looking for?
Little White Lies was established in 2005 as a bi-monthly print magazine committed to championing great movies and the talented people who make them. Combining cutting-edge design, illustration and journalism, we’ve been described as being “at the vanguard of the independent publishing movement.” Our reviews feature a unique tripartite ranking system that captures the different aspects of the movie-going experience. We believe in Truth & Movies.

domain: artistic


text:
Gold Nylon Round All Purpose Paint Brushes - 3 Piece Set
- Brand: The Fine Touch
Paint your world with artistic flair! Gold Nylon Round All Purpose Paint Brushes are perfect for use with oil, watercolors, acrylics, and tempera. Use these brushes to paint on canvas, ceramic, fabric, wood, copper, tin, and more! Create beautiful and colorful paintings and share your art with the world!
Package contains 3 brushes.
Item not available in Hobby Lobby Stores.
Check your local store for availability.

domain: hobby


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Colour plays a massive part in advertising. It can be used for example to attract, repel, enrage, calm, encourage and discourage the viewer. Every day we are all manipulated by colour without us realising it. Red, for example, makes us feel warm or warns of danger. Red is also used to evoke the feeling of power and size, whereas blue is thought of as cold, clean, clear open.
Designers for many years have recognised the relationship between colours and emotions and use these to great effect in their designs.
Here is an infographic showing how top brands utilise colour to promote their brand and how those colours may affect the viewer. We can take this information and use it to good effect in our own designs.
The use of colour can provoke an audience to exhibit certain behaviour. Below I have copied a few paragraphs from a blog (click here) to show how this works.
Warm bright colours
Beige, yellow, orange, pink, red and similar. These are active, eye-catching colours with a friendly nature that may induce a sense of courage and energy.
Warm bright colours visually enlarge objects and make them seem closer. Due to their high visibility, I advise limiting their use among subdued colours.
Cold bright colours
Lavender, silver, azure add subtlety, full of aesthetics and freshness, accents.
Such cold but bright tones enhance a sensation of modernity and professionalism if harmoniously combined with grey. It’s a nice composition for businesses, commerce and service websites especially with health, cosmetic and medicine products.
Cold dark colours
Violet, blue, turquoise, green, navy give a feeling of stability and quality. These shades are often placed as accompanying colours. Although they don’t attract attention they emphasise the content.
Cold dark colours are widely used on business websites for ambitious and hardworking qualities with a special highlight for government, science, automotive and computer products.
Warm dark colours
Gold, purple, brown express classics, tradition, luxury and relaxation. They blend well in expensive and elegant designs for young and rich.
Mixed with cold colours give an impression of modernity and novelty. Perfect for brands engaged in finance, consulting, architectonics and craft.
White, grey and black help to create contrasts and bring all the other colours out. They don’t convey any particular message on their own. Neutrals are here to support their neighbours by playing the role of complementation on websites.
Their use can be truly universal as they work well in a variety of applications. Black can be combined with bright colours and white with dark colours, making a classic, almost universal combination. (blurGroup, 2017)
Another source of reference is www.shutterstock.com/blog/color-psychology-brands. It goes into detail about how some of the top known brands use colour to inform and convey a feeling.
blurGroup. (2017). The Impact of Color in Advertising, Marketing, and Design. [online] Available at: https://www.blurgroup.com/blogs/group/the-impact-of-colour-in-advertising-marketing-and-design/ [Accessed 24 Apr. 2017].
Helpscout.net. (2017). Cite a Website – Cite This For Me. [online] Available at: https://www.helpscout.net/blog/psychology-of-color/ [Accessed 24 Apr. 2017].
Miah, K. (2017). Color Psychology: How Big Brands Use Colors in Advertising and Marketing. [online] The Shutterstock Blog. Available at: http://www.shutterstock.com/blog/color-psychology-brands [Accessed 24 Apr. 2017].

domain: design


Sue Radford (chair) has spent 30 years in the media and has worked for the BBC, ITV and Sky News as a reporter, presenter, broadcast journalist across news, current affairs, arts and children’s. She has held senior management positions in both the commercial and not-for-profit sectors. Sue is Executive Director of Intermission Youth Theatre which helps transform the lives of disadvantaged 16-25 year olds through theatre, mentoring and life skills coaching.
Mark Browning is the CEO of Zinc Media Group PLC one of the UK’s largest nations and regions TV production companies. Zinc Media also own businesses in education and publishing. Prior to this he was Group Managing Director of ITN Productions, which worked across Television, Digital, Commercials, Branded Content and Sports production. In the early 2000’s Mark spent seven years with Heart, where he led the station to number 1 in London.
Matthew Barrett is a two-time Emmy and BAFTA award winning programme maker whose films have appeared on Netflix, BBC1 and BBC2, Channel 4, Discovery, National Geographic and PBS in the US and all over Europe. Matthew specialises in Science, History and Religion. He is currently the in-house executive producer at the independent producer Caravan. Previously he was creative director of the indie WMR and a consultant to WGBH/Boston. He spent 20 years at the BBC, starting out in News and Current Affairs, before moving to the Science and History departments, where he became editor of Horizon on BBC2.
Brian Muir is a town planning consultant and a partner with Muir Smith Evans LLP. For over 40 years Brian has also had a parallel ‘career’ as a radio producer with GRF Christian Radio, based in Glasgow. With GRF he has won over 50 broadcasting awards, including a Sony Gold. He currently chairs the Public Issues Group of the Baptist Union of Scotland and is deputy chair of Trans World Radio UK.
Vikki McLachlan coming soon.
Stephané Alexandre has been working across Film + TV for 10 years. Now as Four8’s in house Creative Producer she hopes to tell compelling and challenging stories around faith and culture. Her work as a Producer spans across a range of branded film campaigns for Star Wars, BBC Storyworks, Greenwich Peninsula, Nokia, Huawei to name a few.


text: After I finished the French millinery kit project for alteredpages I still had some paper left over from the 8 x 8GlitzTouched with Grace paper pad. It just so happens that the boxes that snack crackers come in are the same size as the papers with some extra to wrap around the sides. I used one pattern for the front and a different one for the back and they fit perfectly. All that was needed was some trim, a nice little french lady and ribbon for the handle. You could do the same to a cereal box which also happens to be a little less than 8 x 11 inches wide.


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CHICAGO (MarketWatch) - MSNBC.com has managed to score a top ranking among other news sites, which its general manager credits to the site's devotion to video and key partnerships across the media spectrum.
During the 12-month period between June 2008 and May 2009, MSNBC.com had the most unique visitors among current news and global events Web sites, according to Nielsen Online, topping Yahoo! YHOO News, CNN Digital Network, which is owned by Time-Warner TWX, and FoxNews.com, which is owned by News Corp.
MSNBC.com, which is co-owned by Microsoft
"We're also the main news site for MSN, and we have key partnerships with Newsweek, the New York Times, and parts of the business news space," Tillinghast said in an interview. "We are the news site for all of NBC News. That's the difference between us and CNN. CNN is a Web counterpart to its on-air product. MSNBC cable's online component is just a subset of what's available at MSNBC.com."
MSNBC.com takes advantage of strong TV ratings for the NBC programs represented at the site, including "NBC Nightly News with Brian Williams," the No. 1 network news broadcast; "Today," the top-ranked morning news program, and "Meet the Press," the most-watched Sunday morning public affairs program for the first quarter of 2009.
Video traffic is a big driver for visitors. In the past 12 months, MSNBC.com averaged more than 112 million video streams per month. Tillinghast said the site has designed it player to maximize traffic. Each show that offers video - "NBC Nightly News With Brian Williams," "Meet The Press," "Today" and many others -- has its own custom front page, and each video calls up other videos from the same outlet on related topics.
"We have a very effective video player that drives deep engagement into video, so the player motivates users to watch a lot of video," Tillinghast said.
In many months over the past year, MSNBC.com has had as much as twice as many unique visitors as its nearest newspaper site competitor, underscoring the difficulty newspapers are having in competing with news aggregators.
The video traffic also helps the site against rival news sites operated by newspapers. In May, for instance, the site's monthly average of 37.2 million uniques compared to 16.9 million for NYTimes.com
"Some of the newspaper sites may not be investing in the technology to the extent that we are," Tillinghast said.
After a dismal fourth quarter in 2008 and an even more bleak first quarter of this year, some media outlets were cautiously optimistic about advertising trends during the June period. Tillinghast says MSNBC.com is currently up compared to last year in terms of ad revenue, but the environment remains challenging.
"We are seeing some success in the ad market, but it's hard to say that there's any kind of a resurgence," he said. "We're very, very busy quoting [ad rates] for different proposals. But the demands of advertisers are very high right now. So you have to work much harder for the same dollars than just a few years ago."

domain: news


Prosecutors are asking for a significantly higher bail to be set for Clayton Garzon, the man accused of brutally beating another Davis resident in an alleged hate crime earlier this month.
According to the Yolo County District Attorney's Office, Garzon attacked Lawrence "Mikey" Partida in downtown Davis on Sunday, March 10 "because of the victim's sexual orientation, and because Clayton Daniel Garzon perceived that the victim had this sexual orientation."
Partida, 32, was found lying unconscious by police. He suffered a fractured skull, several fractured bones in his face, and other injuries. The 19-year-old Garzon was arrested four days later, then released the same day on $75,000 bail.
Since then prosecutors decided his bail was too low, given that Garzon was already out on bail in an unrelated felony case, and due to the hate crime enhancements he was charged with on Wednesday. They now seek a $500,000 bail in the case.
If a judge agrees to the request, Garzon would have to either make up the difference or return to jail.
In a complaint filed Wednesday, Garzon was charged with battery causing serious bodily injury, assault by means of force likely to produce great bodily injury, and threatening to cause great bodily injury. All three counts came with hate crime enhancements.
A motion submitted Thursday by Supervising Deputy District Attorney Garrett Hamilton says the burden is on prosecutors to show "changed circumstances" in altering the bail. Among those changed circumstances, "The initial setting of bail failed to include the fact that the defendant's acts constitute a 'hate crime,'" the motion reads.
Also, prosecutors said, Garzon "poses a risk to the public, given that the offense committed in Yolo County occurred while the defendant was on (own recognizance) release from Solano County."
Hamilton said Garzon also faces charges of felony assault with a knife stemming from a fight in Dixon in September 2012. In that incident, four people were injured with stab wounds, and a fifth with head trauma, according to news reports. On Thursday morning Garzon had been scheduled to appear in Solano County court in that case.
"He is clearly a danger to our county, and therefore his bail should reflect that circumstance," Hamilton said in the motion.
Prosecutors also asked that a judge step up Garzon's Yolo County court arraignment, previously scheduled for April 12, to Monday, March 25. That request was granted on Thursday afternoon.
Follow Don Frances at twitter.com/donjfran


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Displaying items 13-24 of 229 » View courant.com items only< Previous 1 2 3 4 5 6 7 8 9 10 11-20 Next >
St. Louis Post-DispatchSen. Claire McCaskill stepped up her drive to curb sexual assaults in the military on Tuesday, a day in which the Pentagon admitted to a worsening problem and President Barack Obama threatened attackers with dishonorable discharge. The Missouri senator'...
Tags: Barack Obama, Sex Crimes, Prosecution, Assault, Sexual Assault
WASHINGTON (AP) — In a surprise twist to the decade-plus effort to ease access to morning-after pills, the government is lowering the age limit to 15 for one brand — Plan B One-Step — and will let it be sold over the counter. Today,...
Seattle TimesSound Transit held groundbreaking ceremonies Friday for a $383 million, 1.6-mile extension of Link light rail from Seattle-Tacoma International Airport to an elevated station at South 200th Street. It will be named Angle Lake Station, after the small...
With no deal in sight to curb our growing national debt, America is going broke. So what do our representatives in Congress plan to do about it? Take a two-week break. Are they trying to see whether their abysmal 13% approval rating can sink any lower?...
WASHINGTON – Step aside, stately Senate. Say hello to vote-a-rama. On Friday, the usually lonely floor of the U.S. Senate was thrown open for that most rare of occurrences – a free-for-all frenzy of amendment-making, which is required for...
Tags: Barack Obama, Tom Coburn, Culture, Paul Ryan, U.S. Senate
Senate Majority Leader Harry Reid and the Democrats in the US Senate have broken the law for four years by not passing a budget. This is the height of criminal gross negligence as US debt passes $16.5 trillion and approaches $17 trillion, as 46 cents of...
Tags: Harry Reid, Elections, Budgets and Budgeting
The House and Senate budget committees presented their fiscal 2014 budget proposals this week with sharply different story lines. For House Budget Committee Chairman Paul Ryan (R-Wis.), the point of the exercise was to chart a path to a balanced budget...
WASHINGTON (AP) — Acting on the Senate's first budget since President Barack Obama took office, a Democratic-led panel is moving toward party-line approval of a fiscal blueprint that would trim the budget deficit while protecting safety net programs...
In case anyone has missed the dueling budget proposals out this week from Rep. Paul Ryan on the Republican side and Sen. Patty Murray for the Democrats, don't fret. You could easily have slept through the last four months and missed nothing. They are...
New budget proposals this week from influential members of the House Republican and Senate Democratic leadership are the stuff of political caricatures. House Budget Committee Chairman Paul D. Ryan (R-Wis.), last year's Republican nominee for vice...
Bloomberg NewsHe's an anti-tax Republican representative from Ohio. She's an antiwar Democratic senator from Washington state. Jim Jordan and Patty Murray have little in common, save this: protecting multibillion-dollar defense projects in their states from budget...
The Washington PostThe fight between President Barack Obama and congressional Republicans over the automatic spending cuts that start next week is shifting from one about stopping them to one about assigning blame if they happen. Obama on Tuesday surrounded himself with...
May 8, 2013 |Story| McClatchy-Tribune
May 1, 2013 |Story| Petoskey News
Apr 27, 2013 |Story| McClatchy-Tribune
Mar 25, 2013 |Story| Los Angeles Times
Mar 22, 2013 |Story| Los Angeles Times
Mar 15, 2013 |Story| Chicago Tribune
Mar 15, 2013 |Story| Los Angeles Times
Mar 14, 2013 |Story| Petoskey News
Mar 13, 2013 |Story| Baltimore Sun
Mar 13, 2013 |Story| Los Angeles Times
Feb 20, 2013 |Story| Courant Plus
Feb 19, 2013 |Story| Courant Plus
Original site for Patty Murray topic gallery.


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Benefits of AMINOSWEET® ASPARTAME
Due to its sugar-like qualities, aspartame provides the same taste as sugar at a much lower cost.
AMINOSWEET® ASPARTAME is the most used sweetener globally due to its clean taste and excellent sweetening capability.
Ajinomoto’s AMINOSWEET® ASPARTAME is of the highest quality and wonderfully sweetens in many applications.
Food and drinks sweetened with aspartame allow people with diabetes to enjoy the pleasure of sweet taste without the sugar. AMINOSWEET® ASPARTAME has no impact on insulin and blood glucose levels.
Due to its significantly similar taste profile to sugar, aspartame is an excellent sweetening solution. It is unique in that it can deliver sugar-like sweetness when used alone without complex taste-modification technology.
AMINOSWEET® ASPARTAME is the only alternative sweetener that is metabolized by the body the same way as all other food.

domain: food


text:
Opposition MPs today petitioned President Ram Nath Kovind for a court-monitored SIT probe into the death of CBI judge B H Loya and said they have no faith in either the CBI or the NIA. PTI file photo
Over 100 MPs, led by Congress president Rahul Gandhi on Friday petitioned President Ram Nath Kovind for an independent Supreme Court-monitored investigation into the death of special judge B H Loya and his two associates, making clear their lack of faith in the CBI and the NIA.
A memorandum signed by 114 MPs from 15 Opposition parties was handed over to the President at the Rashtrapati Bhavan by a multi-party delegation led by Gandhi that included representatives from Congress, CPM, CPI, Trinamool Congress, AAP among others.
"A large number of MPs feel suspicious and uneasy over the death of judge Loya and two others. They wanted an independent probe and did not want the investigation to be handed over to the CBI," Gandhi told reporters. He was flanked by senior leaders including Ghulam Nabi Azad, Kapil Sibal, Anand Sharma, D Raja, T K Rangarajan and Idris Ali.
Gandhi said the president gave them a positive response.
Judge Loya was handling the fake encounter case of Sohrabuddin Sheikh at the time of this death on December 1, 2014. BJP president Amit Shah was one of the accused in the case. He was subsequently discharged citing lack of evidence.
Loya's case came into the spotlight in November last year when his family members raised questions about his death claiming that he was under tremendous pressure regarding the Soharabuddin case.
The Supreme Court is hearing a public interest litigation that seeks an independent probe into judge Loya's case.
"This cannot be decided through public interest," senior Congress leader Kapil Sibal told reporters and demanded a Special Investigation Team of officers selected by the Supreme Court.
"There should be an SIT (Special Investigation Team) but not of CBI officials. We don't trust the CBI or NIA (National Investigation Agency) because we know what CBI and NIA officials do," Sibal said, referring to the 2G spectrum allocation case in which a special court let off all accused including former communications minister A Raja.
"Such a procedure will ensure the credibility of the institution in the eyes of the public. We sincerely hope you will use your good offices to serve the cause of justice," the MPs told the President.
The memorandum also mentioned that two confidants of Loya - lawyer Shrikant Khandalkar and retired district judge Prakash Thombre - also died under suspicious circumstances.
"We believe that if lives of judges and lawyers are jeopardised for doing their duty, then democracy is under grave threat. Recently, four senior-most puisne judges of the Supreme Court also expressed the sentiment that democracy was in peril," the MPs said, referring to the sensational press conference by Supreme Court judges last month that brought to the fore differences in the top judiciary.


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We'll be featuring a super chic Halloween wedding later this week with decor that will blow your mind. But I couldn't wait to share this particular detail: the bride's gold-dipped pumpkin bouquet! Who knew that a simple Halloween container could look so fabulous with some flora and a little paint?
Are you even seeing the huge amount of gorgeous flowers spilling out on all sides? It's like trick-or-treating for compliments when you look this good, Halloween-style. Here it is on the bride, Larke, herself.
Stay tuned for the rest of this amazingly classy and spooky Halloween wedding featuring this pumpkin bouquet later this week. It's a doozy.
Photographer: Russell Gearhart Photography • Event Designer: So Smitten Special Events
Comments on A simple Halloween container becomes a super chic gold pumpkin bouquet
No one can ever imagine of creating such an amazing and unique wedding bouquet, but at offbeatbride it’s possible. I am truly impressed with the thought and creativity . Awesome!
Comments are closed.


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resourcesABOUT MT AUTHOR GUIDELINES CLASSIFIEDS EDITORIAL CALENDAR MEDIA GUIDE MASSAGE MART SCHOOLS & EDUCATION FEEDBACK
Integrative Cancer Care: Chiropractic for Chemotherapy-Induced Hiccups
Hiccups (singultus) are a frequent occurrence during cancer treatment. The cause of the hiccups may be the chemotherapy drug itself, such as Cisplatin; or the prophylactic use of corticosteroids such as Decadron, which is used to prevent nausea and/or vomiting.
Power to the Patient
Against a backdrop of splintered political parties, polarizations within nations, civil unrest, and distrust of established government (such as the growing anti-Washington, D.C. sentiment) comes the not-so-surprising finding that health care authorities and practitioners (with perhaps the exception of insurers) are turning over more and more powers to the individual patient.
Dysautonomia: The Medical Condition You May Already Be Treating
TCM practitioners have spent thousands of years healing patients without knowing or needing the names of their diseases as defined by allopathic medicine. We have syndrome names that are both poetic and efficient.
National Board Apologizes for Testing Issues
The National Board of Chiropractic Examiners (NBCE) has issued a formal apology following a series of computer-based testing malfunctions that impacted two separate examinations (March and June 2016) and caused "widespread confusion and frustration" to the nearly 1,500 examinees taking the tests.
First Annual ICD-10 Updates Take Effect
Yes, there was an update to ICD-10 codes on Oct. 1. It was a regular update to the diagnosis coding system and will take place every Oct. 1, just as it did when the ICD-9 system was in place.
Using the Lens of Chinese Medicine
One of the most common medications I see in clinical practice on a daily basis is fluoxetine or Prozac. Consequently, I hear many complaints concerning the side effects of this medication and am frequently asked by patients to help manage these side effects with acupuncture and Chinese medicine.
Upgrade to "Parker 2.0" in Las Vegas
Continuing your education and refining your practice: two key elements of a successful chiropractic career. Parker Seminars promises both as it celebrates its 65th anniversary in Las Vegas next February, according to Parker University President, Dr. William Morgan, and seminar consultant Dr. Mark Sanna.
Getting Paid by Medicare Is Getting a Major Adjustment
The 2015 Medicare Access and CHIP Reauthorization Act (MACRA) was signed into law to implement a new approach to clinician payments and replace the Sustainable Growth Rate formula.
Going Beyond Just Feeling Good
We all know that most patients come to us for some pain complaint: neck pain, back pain, sciatica, carpal tunnel, etc. We also all know that acupuncture is a great first-line care for these issues, as well as supporting overall health and wellness.
Update from the International AIDS Conference
The 21st International AIDS Conference in Durban, South Africa, brought together more than 15,000 of the world's leading scientists, activists, funders, policy makers, and consumers from 153 countries.
Workers' Back Pain: Causes, Costs & Solution
You will want to share two important papers published in the past several months. Why? When read separately, each provides valuable information relevant to your patients, community and practice; together, they tell a compelling story.
Pediatric Asthma: A Case Study
I have had very good success with pediatric asthma, combining acupuncture with Chinese herbal products. Treatment is given over four to eight months, twice monthly, with herbal formulas rotated every month.
Treating Peripheral Neuropathy: Multi-Faceted Approach Including Laser Therapy
Peripheral neuropathy affects at least 20 million people in the United States1 and nearly 60 percent of all people with diabetes suffer from diabetic neuropathy. Many suffer from the disorder without ever identifying the cause.
Decoding the Mystery of Medical Insurance Acceptance
In the constantly evolving profession of acupuncture, one of the least understood areas is medical insurance acceptance. The profession is filled with controversy surrounding this topic: Is it ethical?
Six Things Every DC Should Know About the Zika Virus
The Zika outbreak continues to spread across the continental United States and U.S. territories. We offer this brief overview on this important public health problem for the practicing doctor of chiropractic.
Natural Cancer Prevention: Pomegranate for the Prostate
In recent years, the ingestion of pure pomegranate juice (8 ounces per day) has been shown in clinical studies with human subjects to slow, and to some degree, reverse, the progression of prostate cancer – the second leading cause of cancer death in North American men.
ITB Syndrome: Treat the Tensor Fascia Latae
Iliotibial band syndrome is usually the result of repetitive knee flexion, such as in runners or cyclists. Pain may be experienced in the knee and/or the hip. The patient may express a sense of the hip dislocating, popping or snapping.
U.S. Olympians Have a DC in Their Corner
It's probably old news to you that doctors of chiropractic play an increasingly prominent role in treating athletes, from youth sports participants to weekend warriors, to elite / professional competitors.
Four Ways to Attract Patients
Acupuncturist A has been in practice for six years and has struggled since day one. She spends as much time and money on marketing as she can, but since her practice is slow, her budget isn't that big.
Treatment Success at the Won Institute
According to the World Health Organization's 2003 report titled, "Acupuncture: Review and Analysis of Controlled Clinical Trials," acupuncture has been shown to improve many physical, emotional, and mental conditions.
August, 2002, Vol. 02, Issue 08
Twelve-Step Program to the Post-ABT Exam Party
By Barbra Esher, AOBTA CI. Dipl. ABT & Ac. (NCCAOM), LAc
In my last column (in the June issue), I suggested how to organize a study group to learn the Asian medicine portion of the NCE. This seems to be the major concern of massage therapists taking the exam, even though it is well-known that the NCE can be passed without knowing the answers to any of these questions.Regardless, many people wrote saying that they appreciated the guidance. I also received letters requesting something similar to study for the National Certification Commission for Acupuncture and Oriental Medicine (NCCAOM) Asian Bodywork Therapy (ABT) exam. I recommend that you use the outline that comes with the exam booklet! This article is based more on my shiatsu program. All of my graduates last year passed the exam, so you may be able to study and review this information and also do well!
If you plan on taking the ABT exam, hopefully you are already registered, as the deadline is August 9. This leaves you 12 weeks to bone-up on your traditional Asian medicine foundation concepts. Get together with as many as you can and commit to supporting each other in knowing this material cold. (Cold being yin, means you learn it to the deep dark depths of your being!)
A good way to organize your time is to divide these 12 "steps" by the number of people studying together, and assign who will teach each week. So if you have 12 people in your group, each person will teach one segment of this material one time. It's best to teach the information that you know the best, so you aren't just reading from a book. Make it fun and interesting, and include as many audio-visual aids as possible. Give out handouts. If you don't know what you are teaching at all, don't worry, you will know it by the time you finish preparing your lesson!
Also, have all the people who are not teaching that week write down five questions on the material presented the previous week. Start each class with a review from the previous week - it could consist of nothing more than answering those questions. Cut the questions apart (so that each question is on a separate piece of paper), put them in a bag and pass it around, randomly picking and answering questions. (This strategy gives everyone the opportunity to think about and consider each question, rather than people just calling out the answers.) You didn't have time to make up questions? Well then, you'll have to make up 10 for next week! A study group takes more of a commitment than just meeting once a week; you have to work at learning this information!
By the way, this system works for any number of people. If there are just two of you, alternate between teaching and writing questions based on the information you've learned the prior week. If it is just you, study the material in a methodical way, and compile a bank of questions to test yourself later.
12 Steps/ 12-Week Program
[Unless otherwise specified, the page numbers referenced in brackets appear in Foundations of Chinese Medicine by Giovanni Maciocia, Churchill Livingston Press.]
Yes, I omitted a lot of detail from this outline -- for example, just about all of the yang organ pathologies. That's because you need to pull back and focus on the big picture. You probably are not going to run across Heat in the Small Intestine in your practice and most people wouldn't consider it "entry-level" knowledge.
Yes, I also left out Western medicine. You need to have taken at least 100 hours of it to sit for the exam but it's such a small percentage of your knowledge base that I wouldn't spend too much of your time reviewing every muscle origin and insertion. (Just as I don't recommend massage therapists learn Asian medicine for the NCE, unless it was a significant part of training.)
I also didn't include questions on the different forms of ABT. Don't worry about the different techniques for styles you don't know. You couldn't possibly, nor would you want, to learn them all. It's more important to know the basic theory. Pulse and tongue is included in all 12 weeks. It's part of learning the signs and symptoms; for example, a reddish tongue for yin deficiency and a swollen, pale tongue for yang deficiency.
One last thing: several textbooks have test questions in the multiple-choice style used on the NCCAOM exams. Check them out to see if they might be useful. TCM Study Guide Series Acupuncture, Kang Tai Press, Chicago; and Tests: Chinese Acupuncture and Moxibustion, Foreign Language Press, Beijing.
Again, I am not telling you what is on the exam, but I am giving you an approach that I know works. I am committed to you succeeding; write me and let me know how you did!
Click here for previous articles by Barbra Esher, AOBTA CI. Dipl. ABT & Ac. (NCCAOM), LAc.
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domain: health


text:
Men who have a disability and who live at home must register with Selective Service if they can reasonably leave their homes and move about independently. A friend or relative may help a disabled man fill out the registration form if he can't do it himself.
These men with disabilities that would disqualify them from military service still must register with Selective Service. Selective Service does not presently have authority to classify men, so even men with obvious handicaps must register, and if needed, classifications would be determined later.
PARENTS / GUARDIANS:
If your son is not confined to an institution or homebound (completely bed bound), he is required to register.
- If a man is placed in a hospital, nursing home, long-term care facility, or mental institution on or before his 18th birthday, had no breaks of institutionalization of 30 days or longer, and remained institutionalized until his 26th birthday, he is not required to register.
- If he is confined to home, whether his own or someone else’s (including group homes), on or before his 18th birthday and cannot leave the home without medical assistance (for example, by ambulance, or with the help of a nurse or EMT), and remained homebound until his 26th birthday, he is not required to register.
Depending on the condition of the young man, while he would not be able to serve in the military in a crisis, it does not exempt him from the Selective Service registration requirement. Even though this may not seem to make any sense, the facts are neither the Military Selective Service Act nor the Presidential proclamation provide an exemption from registration because of a man's mental or physical condition unless Selective Service is provided with documented evidence that the man is hospitalized or institutionalized; or homebound and unable to function outside the home, with or without physical assistance; or is in such a physical or mental condition that he would not comprehend the nature of his registration with the Selective Service System. In these cases, a determination can be made by Selective Service as to whether or not the man qualifies for exemption from registration. Otherwise, Selective Service is not allowed to "classify" men until the Congress and the President authorize a return to the draft in an emergency. Thus, all men must register... even those with obvious disqualifying disabilities.
There is no draft at present; therefore, no classifying being done. The last man was drafted in 1973, after which the U.S. converted to an all-volunteer military. However, Congress and the President still require men to register and the Selective Service System is kept in a standby status, just in case a future crisis necessitates a return to the draft.
It’s important to know that even though a man with disabilities is registered, he will not automatically be inducted into the military. In a crisis requiring a draft, men would be called in a sequence determined by random lottery number and year of birth. At that time, they would be examined for mental, physical, and moral fitness by the military before being deferred or exempted from military service or inducted into the Armed Forces. They would also be eligible for any deferments, postponements, and exemptions available to all other registrants. A man (or his parents/guardian) would have the opportunity, at that time, to provide any necessary medical documentation needed for exemption. Were a draft to be reinstated and if your son received an induction notice to appear for mental, moral, and physical testing, if you provided the Military Entrance Processing Center that sent his notice with sufficient medical documentation on his disabilities, he would probably not even need to appear for the testing.
IF Congress and the President were to reinstate the draft, the first lottery (drawn on a specific date) would include 19-year-old men turning 20 that calendar year and all 20-year-old men. If that failed to provide sufficient manpower, then 21-year-old men would be called for induction testing. Then, the next lottery would again be for new 20 year olds. The older a man becomes who has not yet been called to report for induction, the less likely he will be drafted.
Men are considered no longer draft eligible at age 26; for this to change, the United States Congress would have to amend the law.
You may assist your son in registering with the Selective Service System.
By registering, your son remains eligible to take advantage of certain programs and benefits that Congress has linked to a man’s Selective Service registration: student financial aid, federal employment, and job training under the Workforce Innovation and Opportunity Act (formerly known as the Workforce Investment Act).

domain: law


text:
Can pure vegetable oil use as engine fuel?
Date:2015-01-15 16:25:27 / Cooking oil machine FAQ
Pure vegetable oil use as engine fuel has potential for the most comprehensive ecologic, economic and social benefits of all biofuels. The production involves few process steps and can be done economically with small production units. The production process leads only to small energy losses, because no thermal or chemical process steps are involved. It can be implemented in decentralised small units, without loosing cost-effectiveness and provides potential for additional income generation on farms, thereby strengthening rural economic structures and social coherence in the EU as well as in hot arid and tropical countries. The non-toxicity and the low flammability are further advantages from a logistics point of view.
All other biofuels
have a longer production chain and higher associated energy losses. E.g. ethanol production shows high energy losses because of the required distillation step and synthetic biofuels produced by the thermo-chemical pathway can hardly be produced with efficiency higher than 50% due to high thermal losses of the gasification stage and the fuel synthesis (Fischer-Tropsch or similar).
All biofuels except pure vegetable oil also present a more or less pronounced risk for the environment or for safety due to some degree of toxicity and the generally high flammability.
The low flammability of pure vegetable oil makes it unsuitable for use in conventional diesel engines first of all. Different engine adaptation concepts exist which help to overcome this principle difficulty, including bivalent operation, preheating of vegetable oil and a number of mechanical modifications, notably of the injection system.
Apart from trans-esterification to biodiesel and cracking/ hydrogenation of pure vegetable oil to BtL, both considered as different biofuels, no attempts have been made so far to modify pure plant oil, in order to better match with engine requirements. The reason for that is that the majority of the advocates of pure plant oil use as engine fuel consider any modification of the oil as manipulation of its “natural” character. This unpronounced dogma is questioned in this project.
Pure vegetable oil chemical and physical properties which are relevant for engine combustion are little influenced by growing conditions of the seeds, but depend strongly on the oil press parameters. This leads to very different oil qualities on the market. Engine operation problems in previous fleet demonstration projects were almost exclusively due to vegetable oil not fitting to the only presently existing nor. Hence, fuel quality definition and control are paramount if vegetable oil should play a larger role in the biofuels market.
When used in non-modified engines, pure vegetable oil not only leads to engine damages, in particular in advanced engines, but also to unacceptably high emissions. Especially, particulate emissions at cold starting are tremendously high, while at most other operating ranges pure vegetable oil shows advantages compared to conventional diesel.


Cybertech Hyper-X Plus TLSO Hyperextension Back Brace
AbleData does not produce, distribute or sell any of the products listed on this website, but we provide you with information on how to contact manufacturers or distributors of these products. If you are interested in purchasing a product, you can find companies who sell it below.
The Cybertech Hyper-X Plus TLSO Hyperextension Back Brace is a back brace designed for use by individuals with lumbar pain, with sciatica, spinal stenosis, or stress fractures to the spinal column. The Hyper-X Plus is a brace that works to extend or hyperextend the spine to promote immobilization and to reduce spine and back pain. It stabilizes and controls the body along with the lower lumbar spine. Resistant aluminum frame provides the stabilization and comfort for lumbar back pain. The Hyper-X Plus can be quickly removed with the snap lock addition to the side of the back support. Hinged bands eliminate movement and give the user the comfort and usability to help deal with any injury to the back. The back pad allows greater compression and ads extra support to keep proper posture and fight lumbar spinal pain. Reduces load on the anterior vertebral bodies from T-7 to L2.
Keeps the vertebrae stabilized, allowing the patient to heal and help with back pain treatment.
Materials: Corrosion resistant anodized aluminum frame.
Options: Variable anatomical contour adjustment for proximal sternal frame customization.
- Small Short: 31 inches to 35 inches (Hip Circumference); 15 inches to 19 inches (Height Range).
- Small Regular: 31 inches to 35 inches (Hip Circumference); 17 inches to 19 inches (Height Range).
- Medium Short: 35 inches to 40 inches (Hip Circumference); 17 inches to 21 inches (Height Range).
- Medium Regular: 35 inches to 40 inches (Hip Circumference); 19 inches to 21 inches (Height Range).
- Large Short: 40 inches to 44 inches (Hip Circumference); 19 inches to 21 inches (Height Range).
- Large Regular: 40 inches- 44 inches (Hip Circumference); 21 inches to 23 inches (Height Range).
- Standard and shorter version sizes available.
- Unique quick release closure and snap lock lever mechanism.
- Ease of adjusting without removing screws in both linear and widths.
- Spring loaded hinged pelvic band eliminating migration, assuring patient comfort and compliance.
- Articulating sternal pad optimizes patient comfort.
Adjustable to fit patients correctly.


The story saga continuesby Björn Pohl - UKC Mar/2011
This news story has been read 5,643 times
There is close, and there is close, and then there is ridiculously close.
Paul Robinson has now come even closer than that to repeating Dave Graham's The story of two worlds, 8C+, at Cresciano, Switzerland. Some would even argue he has already done it.
The only thing that went wrong on the otherwise perfect attempt, was he touched a tree slightly while swinging out on what he describes as a "6C move". I've seen the footage and there's no doubt in my mind he would have had no problem doing the move, tree or not, but unfortunately this doesn't matter. A dab is a dab... and as Paul so eloquently put it: "Damn tree."
Britain's Shauna Coxsey managed to secure a second win in a row at the IFSC Boulder World Cup in Kazo, Japan at the weekend, just... Read more
Said Belhaj has repeated Chris Sharma's Paoichulo, 9a+, at Oliana, in Catalunya. This was the Swedish climbers hardest route to... Read more
James McHaffie has added a new E9 6c - House of Talons - to Dinas Cromlech in the Llanberis Pass. The fact that a... Read more
Martin Stránik has repeated The story of two worlds, ~8C, David Graham's sit down start to The Dagger on the... Read more
Giuliano Cameroni, 17, has repeated Fred Nicole's Dreamtime, ~8C, at Cresciano, Switzerland. Giuliano is a Ticino local who... Read more
Samuel Ometz, 19, has repeated Dave Graham's The Story of two worlds, ~8C, at Cresciano, Switzerland. It was quite fitting The... Read more


text:
Welcome! Like the book of the same name, this blog is an eclectic collection of Sherlockian scribblings based on more than a half-century of reading Sherlock Holmes. Please add your own thoughts. You can also follow me on Twitter @DanAndriacco and on my Facebook fan page at Dan Andriacco Mysteries. You might also be interested in my Amazon Author Page. My books are also available at Barnes & Noble and in all main electronic formats including Kindle, Nook, Kobo and iBooks for the iPad.
Friday, January 8, 2016
The Living Legacy of a 14-Year-Old
This month marks the 35th anniversary of my joining the Cincinnati scion society of the Baker Street Irregulars, the Tankerville Club.
That's more than half of my life and most of the history of the Tankerville Club. It's been a great ride. Paul Herbert founded the Tankerville, named after the only club mentioned twice in the Sherlock Holmes Canon, in the late 1970s. He is still our beloved Official Secretary.
A few other scion societies are much older. It's a treat to read about them in "The Scion Societies" section of the very early issues of The Baker Street Journal.
In Volume 1, Number 4 from 1946, for example, Mr. J.N. Williamson announced the formation of The Illustrious Clients of Indianapolis. "Anyone interested in joining this new Scion must past a test taken from the Complete and Immortal Works," he wrote. Fortunately that rule was not still in effect when I joined the Clients a few years ago!
In 1946, Gerald "Jerry" Williamson was all of 14 years old. Thirty-one years later, he write a horror novel. He eventually published more than 40 novels and 150 short stories in the horror genre before his death in 2005. By that time he had long since left Sherlock Holmes and the Clients behind.
But the club he founded still thrives today, with a large and growing membership under the leadership of Steven Doyle, BSI. That's a funny thing about Sherlock Holmes and endeavors connected with him - they have a way of outlasting the mere mortals who gave them birth.
Just ask the shade of Sir Arthur Conan Doyle.
Posted by Doctor Dan at 12:00 AM


text:
According to recent research conducted by the nonprofit National Association of Software and Services Companies (NASSCOM), India has 11% of the world’s Web3 talent.
The number of blockchain specialists working in India is approximately 75,000, making it the world’s third-largest Web3 workforce. According to the industry association, the skill pool is expected to increase by nearly 120% in the next two years.
The number of Web3 startups in India is 450, including four unicorns. A total of $1.3 billion has been invested in the Indian Web3 ecosystem as of April 2022. The geographical reach of Web3 companies in India has also increased by more than 60%.
What else is in the report
In addition to developing tools for decentralized finance, gaming nonfungible token markets, metaverses, decentralized communities, on-chain coordination methods, and other fields, most of the companies featured in the report are developing tools for the development of on-chain modes of coordination.
The NASSCOM is still optimistic about the prospects for Web3’s rapid development in the nation over the next few years, predicting that there will be an increase of 150 million internet users in India and 500 million users of 5G over the next few years.
According to Debjani Ghosh, CEO of NASSCOM, “India’s place in the global Web3 scene has been cemented by its rapid adoption of new technologies, its expanding startup environment, and its vast pool of digital talent.”.
Despite the skepticism about blockchain technology, Indian businesses and governments are embracing it pragmatically, with applications ranging from land registration to education, health and safety, financial services, and enterprise information technology.

domain: finance


text:
Time sets the pattern to follow according to our genetics, from one day to the next wrinkles begin to appear around the eyes and will modify the appearance of the face. As age advances, changes become evident, some of them are the excess of skin on the eyelids, appearance of bags, drooping of the outer corner of the eyes and approach of the eyebrows to the extreme part of them. Fortunately, surgery (always from the specialist's criteria) can help mitigate the inexorable passage of time.
There is a very fast and effective way to eliminate the unsightly bags and wrinkles that appear around the eyes.
Canthoplasty is a surgical procedure that consists of modifying the position of the corner or lateral canthus of the lower eyelid.
Eyelid ptosis or blepharoptosis is manifested by the drooping or lowering of the upper eyelid of at least one eye.


text:
Combining moments of time in woven thread and color has been a journey spanning more than a half century. Every once in a while, it is useful to throw open the cedar chest and take a look at one’s “treasures”. I always try to save a little bit of everything I have woven. Each individual thread you see was a part of a scarf, shawl, blanket, towel, garment, or hanging.
Although I have never actually made a quilt, I believe I am “quiltish”. I love putting many small pieces together to create a cloth bigger than the loom and beyond my imagination.
THE POWER OF GATHERING OVER TIME is a material manifestation of the spirit and an expression of gratitude presented for your enjoyment and the enrichment of the community.
The 144 Lavender Pillows are up in addition to 2 other "quiltish" creations.
Tomorrow is the First Friday opening at The 4 Ravens Gallery in Missoula from 5-8 PM
Below I am brewing up some lavender tea to serve at the opening. It amazes me to see how purple (or you could say "lavender") the water turns when in first contact with the lavender flowers. Soon after it turns a rose gold color.


text:
Primary melanoma of the central nervous system
Synonyms: Malignant melanoma of meninges | Primary melanoma of the CNS
Primary melanoma of the central nervous system is a rare tumor of meninges arising from leptomeningeal melanocytes typically in the perimedullary or high cervical region in the absence of melanoma outside the CNS. The tumor is typically a darkly pigmented solid mass often containing hemorrhagic or necrotic areas composed of sheets of pleomorphic cells with prominent nucleoli with frequent mitotic figures and parenchymal invasion. Intracranial tumor may present with signs of raised intracranial pressure focal neurological symptoms related to tumor location seizures or subarachnoid hemorrhage spinal tumor may present with back pain muscle weakness numbness plegia or urinary incontinence.
Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview.
Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http: //www.orphadata.org. Data version October 2023.
Newly diagnosed with
Primary melanoma of the central nervous system?
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Curing single-gene disorders
COMBINEDBrain is a consortium for outcome measures and biomarkers for neurodevelopmental disorders. We are collaborating to cure rare, non-verbal brain disorders.
My Faulty Gene
My Faulty Gene is a nonprofit organization which provides information and assistance to any individual whose family medical history suggests genetic testing might be helpful in identifying an increased risk of disease due to a genetic mutation. We believe that everyone in need of genetic testing should have access to it.
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My Little Sunshine is a non-profit foundation dedicated to educating people about the importance of fertility preservation and making fertility resources accessible to all.
Educate and provide resources to POC with Rare Cancers
Help Hope Live
Help Hope Live assists individuals living with catastrophic injuries and illnesses to fundraise toward their medical expenses and related costs.
For a list of clinical trials in this disease area, please click here.