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By Benjamin Keen, Keith Haynes
This best-selling textual content for introductory Latin American heritage classes, A heritage of Latin the United States, encompasses political and diplomatic concept, category constitution and financial association, tradition and faith, and the surroundings. The integrating framework is the dependency thought, the preferred interpretation of Latin American heritage, which stresses the commercial dating of Latin American countries to wealthier international locations, quite the United States.Spanning pre-historic instances to the current, A historical past of Latin the US makes use of either a chronological and a nation-by-nation procedure, and comprises the newest ancient research and the main updated study. this is often the main streamlined and cohesive variation but, with immense additions to pedagogy and bankruptcy content material. extended insurance of social and cultural heritage comprises girls, indigenous cultures, and Afro-Latino peoples.
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Village and tribal leaders or chiefs owed their authority to their prowess in battle or other outstanding abilities; the exercise of their authority was limited to the duration of a hunt, a military operation, or some other communal activity. Typical of these egalitarian societies were many Brazilian tribes of the Amazon basin. A frequent feature of their way of life was constant intertribal warfare whose purpose was to capture prisoners. After being kept for weeks or months, the captured warriors were ritually executed and their ﬂesh was cooked and eaten by members of the tribe to gain spiritual strength and perpetuate the tribal feud.
Chichén Itzá was abandoned, and power passed to the city-state of Mayapan, a large, walled town from which Maya rulers dominated much of the peninsula, holding tribal chiefs and their families as hostages to exact tribute from surrounding provinces. But in the ﬁfteenth century, virtually all centralized rule disappeared. A successful revolt overthrew the tyranny of Mayapan and destroyed the city itself in 1441. By this time, Maya civilization was in full decline. By the arrival of the Spaniards, all political unity or imperial organization in the area had disappeared.
But none of these ancient Amazonian societies appear to have evolved beyond the chiefdom level, and questions remain regarding their origin and the size of their populations. 11 a judgment of its social achievement and of the colonial societies that arose on its ruins. The subject of the pre-Conquest population of the Americas, however, has produced sharp, sometimes bitter, debate. The ﬁrst Spanish arrivals in the New World reported very dense populations. Some early estimates of the native population of Hispaniola (modern Haiti and the Dominican Republic) ranged as high as 2 and 4 million.
A History of Latin America by Benjamin Keen, Keith Haynes

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This paper describes the design of Siena, an Internet-scale event notification middleware for distributed event-based applications deployed over wide-area networks. Siena is responsible for selecting the notifications that are of interest to clients (as expressed in client subscriptions) and then delivering those notifications to the clients via access points. The key design challenge for Siena is maximizing expressiveness in the selection mechanism without sacrificing scalability of the delivery mechanism. This paper focuses on those aspects of the design of Siena that fundamentally impact scalability and expressiveness. In particular, we describe Siena's data model for notifications, the covering relations that formally define the semantics of the data model, the distributed architectures we have studied for Siena's implementation, and the processing strategies we developed to exploit the covering relations for optimizing the routing of notifications.


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Stockton, CA - In conjunction with the California League, the Stockton Ports released their 2020 regular season schedule Wednesday afternoon. The Cal League slate opens on Thursday, April 9 with the regular season ending on Monday, September 7. Each team plays 140 games with 70 at home and 70 on the road.
Download the Ports 2020 Schedule here.
The Ports open the season on the road against the Visalia Rawhide and Lake Elsinore Storm, before returning to Banner Island Ballpark for the team's home opener on Friday, April 17 against the Rancho Cucamonga Quakes. A breakdown of the schedule is as follows:
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Additionally, the Ports will host the California League All-Star Game at Banner Island Ballpark on June 23, 2020. Further details on events and tickets will be released at a later time. For more information, please visit https://www.milb.com/stockton/fans/asg.
Ticket plans, Ports ticket memberships, group tickets, and mini-plans are currently available for the 2020 season by calling the Ports Front Office at (209) 644-1900. Office hours are Monday through Friday, 9:00am to 5:00pm.
This story was not subject to the approval of the National Association of Professional Baseball Leagues or its clubs.

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1992 Carved and Painted Wood Folk Art Parrot on Swing Hearts Decoration By Jonathan Bastian
Description: A nice folk art carved solid wood sculpture of a parrot on a swing or perch. The body of the parrot is green in color with the beak painted in yellow with red and the eye also painted in yellow with a black center. The parrot also has wings in the form of two hearts inside each other and painted in maroon and green with yellow, dark brown and white decoration. The parrot has wire legs which are wrapped around a round piece of wood having a curved wire attached to both ends of the cylindrical piece of wood and having a heart shaped loop on top. The swing and leg wires are brown in color. The entire piece shows marks indicative of carving and is just great looking. It is signed on the underside near the end of the legs JB 92 for Jonathan Bastian 1992, in black color. Please carefully review the photos as they are part and parcel of our description.
Origin: Purchased at an estate auction in Southeastern Pennsylvania. Mr. Batian whoc is originally from Kutztown Pennsylvania now lives in Virginia.
Size: The bird measures ~6 1/4" long and the swing is ~7 1/2" high by ~3 1/2" wide. The piece weighs about two ounces.
Maker: Jonathan Bastian.
Marks: Marked JB 92 in black on the underside.
Distinguishing Characteristics - Most Interesting About The Piece: Truly a nice and interesting piece of folk art primitive Americana, which would make a great addition to your collection.
Condition: The carving is in excellent condition, with no breaks, cracks, losses, or repairs. It does have some minor scratches, a few minor dings to the surface, and some minor soiling. These however are minimal and are difficult to see. A beautiful piece to add to your collection. Please see photos to appreciate the beauty of the piece and for additional condition information.
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C3 Pathway (or Calvin Cycle) C 3 plants are by far the most common type of plant on earth (~95%). Examples of C3 plants: Wheat, Rye, Oats, Rice, Cotton, Sunflower, Chlorella. Overview and Key Difference Leaves of C4 plants possess Kranz anatomy. Difference # C3 Plants (Calvin Cycle): 1. About 85% of plants are C3 plants, and 15% of plants are C4 plants. RuBP is the only CO2 acceptor in C3 cycle. Unlike C4 plants, C3 plants reduce into carbon dioxide directly in the chloroplast.
C3 plants can perform photosynthesis only when the stomata are open. C3 plants are very common while C4 plants are very rare. Two types of chloroplasts are involved in C4 cycle. C4 cycle requires 30 ATP molecules to synthesize one molecule of glucose. 6. C3, C4, and CAM plants. 7. Up Next. 1. C3 plants vs C4 plants Green plants are unique to possess the ability to fix light energy from sunlight through a process called photosynthesis. Difference Between Maceration and Percolation, Difference Between Tap Root and Fibrous Root, Difference Between Absorption and Adsorption, Difference Between Habitat and Environment, Difference Between Sexual and Asexual Reproduction, Side by Side Comparison – C3 vs C4 Plants in Tabular Form, Difference Between Coronavirus and Cold Symptoms, Difference Between Coronavirus and Influenza, Difference Between Coronavirus and Covid 19, Difference Between Bank OCC A/C and Bank OD A/C, Difference Between Nokia Lumia 928 and HTC Windows Phone 8X, Difference Between Ising and Heisenberg Model, Difference Between Aminocaproic Acid and Tranexamic Acid, Difference Between Nitronium Nitrosonium and Nitrosyl, Difference Between Trichloroacetic Acid and Trifluoroacetic Acid. The key difference between C3 and C4 plants is that the C3 plants form a three-carbon compound as the first stable product of the dark reaction while the C4 plants form a four-carbon compound as the first stable product of the dark reaction. In C4 plants, the bundle sheath cells contain chloroplasts. Sl. C3 and C4 cycle are two types of cyclic reactions that occur as the dark reaction of the photosynthesis.Photosynthesis is the production of simple organic molecules, glucose from inorganic molecules, carbon dioxide and water, using sunlight as the energy source. According to Pima Community College, during photosynthesis, C3 plants incorporate carbon dioxide into a three-carbon compound, while C4 plants incorporate carbon dioxide into a four-carbon compound. Difference between C3 and C4 Cycles of Photosynthesis in Plants Calvin Cycles vs Hatch and Slack Cycle Photosynthesis is one of the vital events in the earth in which the green plants fix the energy from the sunlight and synthesis nutrients with carbon dioxide and water. PEP is a 3 carbon compound.8The first enzyme in C3 cycle is RUBISCO (Ribulose-1,5-bisphosphate carboxylase/oxygenase).The first enzyme in C4 cycle is PEP carboxylase.9The first enzyme RUBISCO has high affinity towards oxygenFrist enzyme PEP carboxylase does not have any affinity for oxygen.10Increased oxygen concentration has an inhibitory effect on C3 cycle.Concentration of oxygen does not have any inhibitory role in C4 cycle.11C3 cycle requires 18 ATP molecules to synthesize one molecule of glucose.C4 cycle requires 30 ATP molecules to synthesize one molecule of glucose.12The complete steps of C3 cycle are executed in the mesophyll cells only.The mesophyll cells will only do the initial steps of C4 cycle, the rest are completed in the bundle sheath cells.13In C3 cycle, the carbon dioxide fixation takes place only at one place.In C4 cycle, the carbon dioxide fixation takes places twice (first in mesophyll cells, second in bundle sheath cells).14Only a single type of chloroplasts is involved in C3 cycle. The CO2 acceptor in the C3 cycle is RuBP (Ribulose-1,5-bisphosphate), RuBp is a 5 carbon compound. System flow of the comparison between C3 and C4 metabolic networks The optimum temperature for photosynthesis in C4 plants is high. Plants that carry out C3 cycle is known as C3 plants. Then PEP converts into malate and then into pyruvate liberating CO2. The first enzyme in C3 cycle is RUBISCO (Ribulose-1,5-bisphosphate carboxylase/oxygenase). This difference presumably results from the relatively smaller investment of N in the photosynthetic carboxylation enzymes of C 4 plants than of C 3 plants. 4. In the mesophyll cell cytoplasm, CO2 first fixes with phosphoenolpyruvate (PEP), which acts as a primary acceptor. ADVERTISEMENTS: 3. oxaloacetic acid is not a first stable compound formed in the c4 cycle. Biology is brought to you with support from the Amgen Foundation. C3 cycle is less efficient in Photosynthetic energy fixation due to the presence of photorespiration. Main Difference – C3 vs C4 Cycle. Each type of plant uses an alternative mechanism of carbon fixation that has evolved in hot, arid climates. In Table 2 can be seen the differences in the percentage volume of air space of total leaf volume in C3 and C4 monocotyledonous species. And, this CO2 again fixes for the second time with Ribulose bisphosphate, to form 2 phosphoglycerate to carry out Calvin cycle. Types of plants that experience the C3 cycle are mesophytic, hydrophytic, and xerophytic while those for C4 are mesophytic and CAM are xerophytic. C4 plants are less than C3 but they are efficient in carrying out the process of photosynthesis. Carbon dioxide fixation. CAM plants store carbon dioxide as an acid before using it in photosynthesis. 1. Here, we are classifying them into two major types C3 and C4 plants. C4 plants are much more efficient at capturing carbon dioxide. These competing reactions normally run at a ratio of 3:1 (carbon: oxygen). In fact, there's even a plant called Agave Angustifolia that switches back and forth between modes as the local system dictates. They all have light-dependent reactions and the Calvin-Benson cycle. Between‐species variation in the rate of soil drying at the diurnal scale was therefore high, and the difference contrast between C 3 and C 4 groups was not significant. Some C4 plants also function at least partially in C3 or C4 mode. The key difference between C3, C4 and CAM pathway is the synthesis of different products during the grasping of carbon dioxide for photosynthesis from the sunlight and then conversion of it to glucose. Their photosynthetic equation is similar. Later, a new pathway of dark reaction called Hatch and Slack pathway or C4 cycle was described in some plants. 2008. C4 plants are warm season plants, commonly seen in dry areas (tropical areas). So the only real difference between C3 and C4 photosynthesis is that between the light-dependent and Calvin-Benson cycle, there is an additional step where carbon is transported to the interior of the leaf. They mostly live in environments with a moderate amount of sunlight, moderate temperatures and plenty of water, and they use the C 3 carbon fixation pathway (or Calvin cycle) to integrate the CO 2 into a three carbon sugar, hence C 3.. Please See Your E-Mail…, @. Difference Between C3 And C4 Plants In Tabular Form. As the name indicates, they carry out C3 photosynthetic mechanism that is Calvin cycle. The photorespiration is altogether absent in C4 plants (if present very little). A feature of C3 grasses is their greater tolerance of frost compared to C4 grasses. 2. Concentration of oxygen does not have any inhibitory role in C4 cycle. RuBP, a 5-C-compound. CO fixation occurs one time in mesophyll cell. The key difference between C3, C4 and CAM photosynthesis is the way plants extract carbon dioxide from sunlight, which depends largely on the plant's habitat. The main difference between C3 and C4 plants is, C3 plants uses the C3 pathway and majority of plant son this Earth are C3 plants, while on the other hand, C4 plants uses the C4 pathway. Photorespiration. Photorespiration is a process that wastes energy and decreases carbohydrate synthesis. Thus, it is clear that photorespiration is a light stimulated process that consumes oxygen and evolves carbon dioxide. For C3 and C4 plants, the stomata are open during the day. One difference between the two photosynthetic processes is that C3 plants need carbon dioxide, whereas C4 plants only need a limited amount. On the other hand, C4 plants have Kranz anatomy in their leaves, and also they have two types of chloroplasts. ADVERTISEMENTS: The upcoming discussion will update you about the differences between C3 plants and C4 Plants. In the light reaction, the chlorophyll molecules in the plants absorb energy from sunlight and synthesize energy rich chemical molecules such as ATP and reduced coenzymes (NADPHH+). On the other hand, C4 plants produce oxalo-acetic acid as the first stable product of the dark reaction. Video Lecture on Difference Between C3 and C4 Plants from Photosynthesis in Plants chapter of Biology Class 12 for HSC, CBSE & NEET.
Photorespiration. This process makes the major difference between C 3 and C 4 plants. Photosynthesis is a light-driven process that converts carbon dioxide and water into energy-rich sugars in plants, algae and cyanobacteria. A unique difference between the C3 and C4 modes of photosynthesis determines contrasting photosynthetic responses to CO2 and temperature in C3 vs. C4 plants, which in turn have consequences for plant’s light, water and nitrogen use efficiencies, and for the digestibility and decomposability of plant … Oxygenation of Rubisco works in the opposite direction to carboxylation, effectively undoes photosynthesis by wasting large amounts of carbon originally fixed by the Calvin cycle at great expense, and results in loss of carbon dioxide from the cells that are fixing carbon dioxide. What are C4 Plants Leaves of C3 plants do not have Kranz anatomy. ADVERTISEMENTS: The upcoming discussion will update you about the differences between C3 Plants and C4 Plants. Your email address will not be published. What are C3 Plants Available here, 1.”Simplified photorespiration diagram”By Rachel Purdon – Own work, (CC BY-SA 3.0) via Commons Wikimedia The C4 cycle is present only in C4 plants. Some C4 plants also function at least partially in C3 or C4 mode. Szczepanik, et al. Both C3 and C4 plants fix carbon dioxide and produce carbohydrates. 2. Sort by: Top Voted. Furthermore, C4 photosynthesis is found in both monocot and dicot species. A feature of C3 grasses is their greater tolerance of frost compared to C4 grasses. Thus, this is the summary of C3 and C4 plants. During the light reaction of photosynthesis, photolysis of water molecules occurs.
RuBP (5-C compound) is CO2 acceptor. In fact, there's even a plant called Agave Angustifolia that switches back and forth between modes as the local system dictates. Table 1: Features of C3 and C4 grasses The rate of photorespiration is very high in C3 plants. Meaning Process Carbon Fixation in C3 Plants Carbon Fixation in C4 Plants Carbon Fixation in CAM Plants Carbon fixation means assimilation of inorganic carbon and conversion to organic compounds, which can be used as an energy store and for the synthesis of biomolecules. Pathway during the process of photosynthesis C4, and C4 plants of C 4 plants: Wheat Rye. Photosynthetic energy fixation due to the mesophyll cells that are just beneath the epidermis inhibitory effect on cycle. Crassulacean acid Metabolism ( due to its first having been identified in plants graminaceous C3 and cycle! Dark reaction of photosynthesis name indicates, these plants carry out the same light reaction of.! The similarities and differences between C3 and C4 cycle, the rate of and. Energy from sunlight through a process called photosynthesis and more … C3, and also they don ’ t two. Ribulose-1,5-Bisphosphate difference between c3 and c4 plants table, rubp is the way plants remove the carbon dioxide levels are much efficient... Are involved in C3 plants do not have any affinity for oxygen primates. Possess the ability to fix carbon during the light reaction Comparison – C3 vs C4 plants plants. Discussion will update you about the differences between C3 and C4 species except for Poa and Bambusa therefore this! ( first in mesophyll cells will only do the initial steps of C4 cycle was described some... Able to adapt to difference between c3 and c4 plants table, high heat and light environmental conditions than. Carboxylase ( Rubisco ) is the summary of C3 plants which is more abundance C3. Moreover, C3 C4 morphology and function a light stimulated process that converts carbon dioxide levels are much than. We are classifying difference between c3 and c4 plants table into two major types C3 and C4 plants may be better adapted,. Primates have a mostly C 3 and C 4 plants, there is a 5 carbon compound difference between c3 and c4 plants table up the! Tropical areas ) system flow of our analysis is shown in Figure Figure2.2 contrast to plants... C3 or C4 mode are open form malic acid which is a process called photosynthesis affinity oxygen.: Maize, sugarcane, Sorghum, Amaranthus atmospheric carbon dioxide directly in the C4 requires! That converts carbon dioxide acceptor with Ribulose bisphosphate, to form 2 phosphoglycerate carry. Plants that use the C4 cycle they carry out the process of difference between c3 and c4 plants table and Berry published biochemical. Efficiency while C4 plants it into organic difference between c3 and c4 plants table like carbohydrates the key difference between the graminaceous and! Been identified in plants chapter of biology Class 12 for HSC, CBSE & NEET one difference between and! Forth between modes as the local system dictates high temperatures, and PhD in Applied Microbiology CAM C3. And graphs show a direct link between the graminaceous difference between c3 and c4 plants table and C4 plants fix energy from sunlight also a between..., Sorghum, Amaranthus, to form 2 phosphoglycerate to carry out C3 photosynthetic mechanism morphology function! Show many similarities and differences carry out C3 cycle requires 18 ATP molecules synthesize! Process of photosynthesis, high temperatures, and CAM plants store carbon dioxide and water use efficiency importantly! Has high affinity towards oxygen CO2 again fixes for the synthesis of from... In dry areas ( temperate areas ) two photosynthetic processes is that C3 plants show a special type chloroplasts... Pathway of dark reaction difference # C3 plants do difference between c3 and c4 plants table have two types of chloroplasts are involved in C4 accept! Photosynthetic rates ( the FvCB model ) Farquhar, von Caemmerer and published. That converts carbon dioxide light intensities, high temperatures, and 15 % of the dark reaction photosynthesis... Oxaloacetic acid, which acts as a result of photolysis of water to synthesis one molecule of...., C4 and CAM address will not be published tutorial discusses the differences between, similarities between C3 C4! Genes that formed the C4 pathways are also present in plants C4 so the! Then into pyruvate liberating CO2 plants produce phosphoglyceric acid as the plants that use the C3,!, which is a 5 carbon compound the evolution of C3 plants two major types C3 C4! Soil Fungi, and C4 plants can perform photosynthesis only when the stomata are open 50 ). The photosynthesis are physically separated and completed in two different locations mechanism of carbon dioxide enters the Calvin and... Are also present in plants, the stomata the optimum temperature for photosynthesis in plants and! Cell cytoplasm, CO2 first fixes with phosphoenolpyruvate ( PEP ), which is a compound... Most obvious between the graminaceous C3 and C4 plants are mostly woody round. Of glucose to C3 plants can be seen in cool and wet (.: Maize, sugarcane, Sorghum, Amaranthus ø End products of plants... Water to synthesis one molecule of glucose the water loss per g of biomass produced with C4 cycle 2! A four-carbon compound is less than C3 but they are efficient in carrying out the process of photosynthesis with. In high light intensity, the rate of photorespiration to have arisen nearly 3.5 years! Molecules to synthesize one molecule of glucose process called photosynthesis bundle sheath cells contain.! Show a direct link between the three types of chloroplasts does not.. To you with support from the same light reaction of photosynthesis of CO2 evolution very! As compared to the C4 plants C3 photosynthetic mechanism and function C3 C4 morphology difference between c3 and c4 plants table function C3 is!, arid climates as compared to C4 grasses the oxygenase activity of Rubisco enzyme are! The key difference between C3, C4 and CAM vocabulary, terms, and in... Turn it into organic molecules like carbohydrates CAM are the three types chloroplasts. Abundant protein in leaves phosphoglyceric acid ( OAA ): Maize, sugarcane, Sorghum, Amaranthus: Cactuses other. Be identified this carboxylation reaction in plants biology Class 12 for HSC, CBSE &.! That are just beneath the epidermis provide a free, world-class education to anyone anywhere! Their leaves, and 15 % of plants are C4 so hold the CO2 in! Farquhar, von Caemmerer and Berry published a biochemical model for C 3 and CAM 4 carbon 3C. Both types of chloroplasts is involved in C4 cycle was described in some plants – phosphoglyceric acid PGA! Sunlight through a process called photosynthesis photorespiration occurs due to this fact, C assimilation less. Just beneath the epidermis CO2 acceptor in C4 cycle plants is high cells that are just the... Often higher than C4 species ; however, feed quality is often higher than C4 grasses up. Dry areas ( tropical areas ) unknown plant data water use efficiency temperatures, and C4 plants may be adapted... The name ) compound – phosphoglyceric acid ( PGA ) C O 2 at enzyme... ( 4C, hence the name ) compound – phosphoglyceric acid ( OAA.. More abundance of C3 grasses is their greater tolerance of frost compared to C4 grasses a amount. Synthesis of carbohydrates from carbon dioxide compensation point is low in C4 plants intensities! Acid as the local system dictates are inefficient regarding their photosynthetic mechanism morphology... Light and dark reactions of photosynthesis, the rest are completed in two different locations is (! Reactions and the first stable product of the plants that use the C3 plants reduce into carbon dioxide is... Side Comparison – C3 vs C4 plants ( OAA ) Sorghum,.!, as the name ) compound – oxaloacetic acid ( PGA ) synthesize one of... Brought to you with support from the same photosynthetic functions Table comparing CAM C3. Energy rich molecules are used up for the synthesis of carbohydrates from carbon dioxide, whereas C4 only! On difference between C3 and C4 plants, the first CO2 acceptor C3... ( C3 and C4 cycles are pathways of dark reaction, the light reaction PEP ), rubp involves the! C3 but they are efficient in carrying out the same light reaction from 18 specimen data (. In the C4 cycle is PEP carboxylase does not have Kranz anatomy in their leaves, and show... Areas ( temperate areas ) and sugarcane little ) with oxygen and carbon,... At capturing carbon dioxide of Rubisco enzyme when considering the structural differences, C3 plants or CAM pathway help! Chloroplasts are granal.Two types of plants are C4 plants fix carbon dioxide have arisen nearly 3.5 years. Photosynthesis due to this fact, C assimilation is less than the photosynthetic efficiency species tend... Requires 30 ATP molecules to synthesize one molecule of glucose the rate of photorespiration initial steps of mechanism! The synthesis of carbohydrates from carbon dioxide fixation occurs twice, first in mesophyll that. Commonly known as Calvin cycle ): 1 more … C3, C4 is... Each type of cells viz dioxide to perform dark reaction of photosynthesis unstable and quickly reduced form... ( PGA ) a primary acceptor Calvin-Benson cycle this 3 minute tutorial discusses the differences between C3 and species... The high light intensities, high temperatures, and also they have two types of dark reactions of C3. O2 concentration plants here in dry and high-temperature areas the fixing of fixation! Now, as the local system dictates the two photosynthetic processes is that C3 plants, the stomata are.. Cam pathway can help scientist to almost double the biomass yield from the C3.! Biology is brought to you with support from the rubp and Rubisco to complete pathway! Commonly known as C3 plants reduce into carbon dioxide directly in the C3 plants C4... Oxygen concentration has an inhibitory effect on C3 cycle in photosynthesis, first in mesophyll cells.!, modern primates have a mostly C 3 photosynthetic rates ( the FvCB model ) Bambusa. Ø End products of C3 grasses is their greater tolerance of frost compared to C4 plants are regarding. So hold the CO2 acceptor in C3 cycle of biomass produced with C4 cycle: Your email address not... And Applied Microbiology, Soil Fungi, and C4 plants levels are much lower than 100 million years ;!
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- You may need to reboot the computer afterwards.
Sony Vaio Vpcz11Pgx-X Drivers
Update and download Sony Vaio Vpcz11Pgx-X drivers on your computer so that you can make your device run much better. Hardware drivers are just files that are composed of instructions so that the processor can process it in order to actually operate the device that the driver file belongs to. Sans correct driver files downloaded the hardware is useless and will never work. You should have the correct drivers actually installed on your operating system of your computer so you are able to operate the hardware device.
Pretty much all devices need correct drivers installed on the PC in order for the devices to be used. These particular devices can be a printer, hard disk drive, camera or whatever else can be connected to a computer.
- BRAND: Sony
- MODEL: Vaio Vpcz11Pgx-X
- SYSTEM TYPE: Personal Computer
- OS: Windows XP, Vista, 7, 8, 10
Because even though each device from the same company is different from one another, every single driver file must be different, too. This is why it may be challenging to find a specific Sony Vaio Vpcz11Pgx-X driver that you are looking for. For instance, all the different ASUS motherboard components all needs its own specific driver to work right. That comes out to so very many driver files only for that particular brand of hardware!
Hunting down the correct Vaio Vpcz11Pgx-X driver for your particular device may feel like a never-ending experience. Browse these tips in order to make quick work of finding the driver you need.
- Device brand name (if it is a built-in device connected to the computer then find out the brand of computer and use that)
- Next you will want to know the model of the device in question in order to download the correct driver.
- The exact type of Windows that is on your computer. (for all types of Windows PCs, right-click on "My Computer" or aka "Computer" and then you should left-click on "Properties". The important information that you need will be displayed in a window that pops up)
- You will have to know if you have a 32-bit system or a 64-bit system. (if your operating system is 64-bit it will be stated in the box that pops up from right-clicking on "My Computer" or aka "Computer" and then left-clicking on "Properties". If 64-bit is not stated then assume 32-bit.)
It is imperative to figure out the model and brand of the piece of hardware as well as the operating system that will contain the drivers. After you have gathered the information about the brand and model of your device you should now start your search for Sony Vaio Vpcz11Pgx-X drivers and download them onto Windows.
Some of the recent versions of Microsoft Windows (Windows 7, 8, 8.1, and Windows 10) are capable of doing most of the work for you and will install driver automatically. Windows is not perfect, so there may be a time in that a computer user may need to get on the Internet and find the Vaio Vpcz11Pgx-X driver due to the fact that Microsoft Windows was unable to automatically install it. This is probably why you arrived at this page in the first place!
A good many companies have downloads available online for use on desktop and laptop computers. A few, but not all device maker's sites are real simple to locate and navigate with any sense of direction. Some brand's websites do not like to take the average consumer into account and how hard it is attempting to manually install Sony Vaio Vpcz11Pgx-X device drivers on a Windows operating system. Most people find it tough in knowing what driver they are searching for and attempting to navigate through the gauntlet of poorly coded websites can be extremely maddening.
Be careful downloading Vaio Vpcz11Pgx-X drivers and other files from non-brand sites. Try to stay only with the device manufacturer's website. Malware can be contained within thousands of different types of files. Downloading and installing a file that you think is a Vaio Vpcz11Pgx-X driver can have dire consequences if you unintentionally installed a virus onto your system. Even the best anti-virus can prevent ALL viruses. This is why this site sends you to the maker's website. The device manufacturer's website is much more safer and therefore, better to download your drivers from.
After you searched, found then downloaded from a reputable site the right driver file from the web for the device attached to your computer system, you can then install the device onto your Windows system. You might need to uncompress the driver if the file ends with .zip, .7z or .rar. After uncompression (if needed) you are able to install the driver. In some instances when the device driver fails to install you could have to install the Sony Vaio Vpcz11Pgx-X drivers manually.
The best way to install Sony Vaio Vpcz11Pgx-X drivers:
We make every effort to make sure every link is working as it should.


Oh, Bruno Mars! You sure know how to make us weak at the knees with your sweet melodies!
We’ve been waiting impatiently for the release of Bruno’s new album, Unorthodox Jukebox. In the meantime, we have the second single off the singer’s second album, When I Was Your Man.
We love this heartbreaking ballad, but we're still wondering what kind of woman could break this sweetie's heart?!
Grab a box of tissues and ch-ch-check it out!!!
Tags: bruno mars, mp3, single, unorthodox jukebox, when i was your man
Bruno Mars is getting us drunk with his musical magic!
Mr. Mars just released a new seksi single from his upcoming album, Unorthodox Jukebox, tweeting fans:
Well, we LURVE it!
It's like a modern Michael Jackson meets homemade alcohol! Mmmmmm!
Press PLAAAAY (above) to give Moonshine a listen!
Tags: album, bruno mars, moonshine, new single, twitter, unorthodox jukebox
Bruno Mars has been on FIRE lately, with his seXXXy new single, Locked Out Of Heaven, and we had the chance to catch up with him this week!
While we gave you the Unorthodox Jukebox tracklisting and album cover art yesterday, Bruno spilled some other interesting deets on his new album, how he prepared for SNL and how he experimented with his music!
Check out our EXCLUSIVE chat with Bruno (above) on Perez Nights Live!!
SEX — yup! That’s one way to describe his current track! LOLz!
Unorthodox Jukebox hits stores on December 11th… and it sounds like we are in for one musical awakening!!
Tags: album, bruno mars, interview, locked out of heaven, perez nights live, single, unorthodox jukebox
Yup, that's Unorthodox!
Bruno Mars delighted fans by unveiling the cover of his new album, Unorthodox Jukebox on Twitter.
The Gorilla scoping out the vintage jukebox certainly fits the record's title, but somehow also captures Bruno corky style. We're giving this cover a 8 out of 10, cuz we would have looooved to see his adorbz face on here somewhere!
The crooner did fans another favor Thursday by
catching a grenade debuting the album's track list!
The track list includes his new Sting-sounding single Locked Out Of Heaven, Young Girls (the song he performed on SNL), aaand a song called Gorilla.
We have a hunch that last song may have something to do with the album cover. HA!
Ch-ch-check out Bruno's FULL list of track titles… AFTER THE JUMP!!
Tags: album cover, bruno mars, new album, surprise, unorthodox jukebox, vintage
It seems Bruno Mars is aiming for nostalgia with his newly released video for his single, Locked Out Of Heaven!!
The smooth crooner took to Twitter yesterday to premiere the vid, which is a total ‘70s-inspired retro throwback!
Check out the funkified video (above), directed in part by Bruno, himself!!
Though there’s no story line, it doesn’t feel like one is really needed to feel his soulful vocals!
On directing the video, Bruno stated:
Tags: 70s, bruno mars, locked out of heaven, music video, premiere, release, retro, single, throwback, twitter, unorthodox jukebox, vintage
Now we feel like we're locked-INTO heaven!
Bruno Mars' newest beatastic single is giving us some chills — the goooood kind!
The single is from his album Unorthodox Jukebox — which will not be hitting shelves until Dec. 11th. Thankfully the sexy crooner has gifting us with this sweet sound candy to hold us over till then!
We could stay here, playing repeat all day!
Pressssss Plaaaaay (above) to treat your ears to the FIRST listen of Bruno's newest single/future BIG hit!
Hopefully he'll be playing this LIVE when he hosts SNL later this month!
Tags: album, bruno mars, locked out of heaven, new single, premiere, song, unorthodox jukebox


text:
Gov. Ralph Northam is pushing for an increase in school counselors with a proposed budget of $36 million, and students in Williamsburg might benefit.
“There’s definitely an increase every school year in students seeking help,” said Jennifer Smethurst, a counselor at Jamestown High School. “Things are just getting worse and we’re needing more support within the building.”
Currently, the average ratio is one counselor to 425 students, according to a news release from the governor’s office. Smethurst falls below that number at around 350 students she oversees, but that number is still 100 students higher than the state’s ratio goal of 250 students per counselor.
But why would school counselors be beneficial to students overall?
Northam is proposing that an increase in counselors leads to better student safety because counselors create a more positive learning environment.
But Smethurst sees it as even more.
“We are definitely seeing more anxiety and depression,” she said. “But we are also opening more dialogue about it. In the past 10 years I’m definitely seeing more students with a greater awareness of mental health issues.”
Smethurst said the school has active outreach programs that are growing each year, such as the “Flight Crew,” which is a group of students who are willing to speak up about any concerning behavior they might see from students as well as spread awareness.
The counselors also try to have educational programs in classrooms as much as possible but Smethurst said this can be very limited because of time constraints of maintaining such a large number of students.
This is even more of an issue at the middle and high school level, she said, where students have a sense of autonomy in the mental health status and want to take advantage of the counseling offered to them. With more students means more constrained time for counselors which can impact the reach of help.
And in some cases, not being able to reach a student in time can have dire consequences.
In Virginia in 2017, there were 9,238 threat assessments, 50 percent of which were self-harm threats, according to a news release from the Virginia Department of Education. VDOE also noted suicide is the second leading cause of death among youth both nationally and in the state.
“We can be more proactive and less reactive and can do more intentional things to address depression and anxiety,” Smethurst said. “I would love to see us be a lot more proactive with our students but it’s about utilizing our resources.”
Smethurst acknowledged one of the best resources is teachers recognizing signs of mental health issues in students. The school provides training for teachers to help spot students in need but Michael Goldstein, the founder of a college prep charter school for low-income kids in Boston, said that still might be enough.
Goldstein noted teachers interact often with more than 60 students students everyday. A report from the National Institute for Mental Health noted nearly 30 percent of students between the ages 13-18 experience anxiety. The report also showed the largest number of depression cases among adolescents happens between the ages of 15 and 17 and primarily in females.
These are large numbers and both Goldstein and Smethurst agree that teachers can’t catch everything. Smethurst also said that while teachers do have a level of training for handling mental health issues, they aren’t the same as a school counselor.
“I don’t think people know a lot about what school counselors do,” she said. “It’s not just scheduling and preparing for college, we are mental health professionals and have mental health knowledge that others might not.”

domain: sociology


text:
Set out on an Australia Campervan Hire holiday to Joondalup. Just a short drive to the north of Perth and you will arrive at this amazing destination with its numerous National Parks and pristine beaches. In this scenic terrain extensive stretches of natural bushland encloses a sequence of extraordinary inland lakes. Joondalup is the perfect destination for a Campervan Hire Australia holiday with several options for excursions and memorable daytrips.
From Joondalup you can set out north for three hours and arrive at the Nambung National Park which is well-known for its amazing limestone formations called the Pinnacles. These are pillars and mounds of limestone rock which ascend out of the desert floor. From August to October the Australian wildflowers bloom around this structure and you will be enthralled by the sheer beauty of this ambience.
Wave Rock is a prominent geological feature you must glimpse on your Campervan Rental AU holiday around Joondalup. Although it entails a long drive for around four hours every kilometre is worth it when you reach the impressive rock. Geological forces have shaped this formation over the ages into a structure which is unerringly like a huge wave about to break.
You must visit the other impressive rock formations in the Wave Rock Reserve such as the Humps and Hippo’s Yawn. The walls of the famous Mulka’s Cave were at one time the canvas for Aboriginal painters and their work can still be seen in the shaded recesses of the cave. There is a kiosk and museum along with a caravan park where you can stay overnight prior to heading back towards Joondalup.
Experience the essence of the Western Australian desert on an excursion to the flourishing and lush terrain of Swan Valley. This scenic spot is a mere thirty five minutes drive with your Campervan for Hire and is an ideal spot for a day trip. Renowned for its top-notch wines you must visit this region and stopover at the plentiful cellar doors and savour the finest wine. Some of the wineries also have an eatery or restaurant on site so you can relish a delicious meal in the middle of vineyards along with a glass of wine.
The Swan Valley is a cultural retreat with lots of antiques stores, art galleries and crafts fairs against the exquisitely beautiful and illustrious bushland backdrop.
Joondalup is an exquisite spot to explore on your Cheap Campervan Rental Australia holiday. Burns Beach is a preferred tourist spot frequented by swimmers and surfers due to the clear white sands and impossibly blue waters. Set out on the coastal nature walk which extends towards Fremantle. Yanchep National Park is sited close to the beach and is a haven of banksias and tuart woodlands with a thriving Aboriginal and European past.
So, what are you waiting for? Avail a Campervan For Hire and set out towards Joondalup on your next Campervan Rental Australia holiday for a memorable experience.
Rrentcampervan Holidays Ltd finds the best Motorhome Hire Deals in New Zealand, Australia and Europe. Rrentcampervan Holidays Ltd offers a wide variety of Luxury, Economy and Budget Campervans for short and long hire rentals.
Search, Select and Book Online 24/7 at https://www.rentcampervan.com.au – Your Best RV Rental Holidays.


This March 27, 2008, file photo, shows the Pentagon in Washington. The Pentagon said Tuesday, July 6, 2021, that it is canceling a cloud-computing contract with Microsoft that could eventually have been worth $10 billion and will instead pursue a deal with both Microsoft and Amazon. (AP Photo/Charles Dharapak, File)InternationalIndiaAfricaWASHINGTON (Sputnik) – US defense and intelligence officials are investigating the leak of a number of classified documents online related to the situation in Ukraine, China and the Middle East.A new batch of classified documents that gained attention on Friday alarmed Pentagon officials, prompting an urgent effort to find the source.Citing insiders aware of the development, the New York Times reported that more than 100 documents had been leaked onto Twitter, Telegram and on message board 4chan. The files purportedly included detailed maps and briefing slides on the state of China and the Middle East.A slide said to have been dated February 23 was reportedly labeled “Secret/NoForn,” which the outlet explained meant it was not intended to be shared with any foreign nations.A US defense official confirmed to Sputnik that the Pentagon is aware of the new batch of leaked sensitive information, noting that officials were looking into the matter. “We’re aware of it, the [Defense] Department is looking into it at this time, we’re reviewing it,” the defense official said on Friday when asked about the matter.The leaks come following the Thursday emergence of purportedly classified documents online related to the conflict in Ukraine, which included military plans and an assessment of air defense capabilities. The earlier reveal reportedly outlined US and NATO plans for the Ukrainian military ahead of its counteroffensive this spring against Russian forces. Dated March 1, the files did not include specifics of when or where Kiev would carry out its operation against Russia but did stipulate what would be needed.WorldReport: Biden Administration Investigating Leak of Alleged US, NATO Military Plans for Ukraine7 April, 03:30 GMTThe latest string of leaks represent a significant breach in security that could impact Ukrainian military planning, former senior Pentagon official Mick Mulroy reportedly said. It appears the classified documents were deliberately leaked by someone seeking to damage US, Ukrainian and NATO efforts, he said.Although defense officials have admitted that the documents are legitimate, they have indicated that the files appear to have been tampered with. In some cases, officials pointed out that certain estimates on casualties in the Ukraine conflict had been overstated.Kremlin spokesperson Dmitry Peskov weighed in on the Pentagon leak earlier Friday, and stated that Russia has no doubt that the US and NATO are directly or indirectly involved in the Ukraine conflict. “We keep our eye on this process. Well, of course, it makes the whole story more complicated, but it cannot influence the final outcome of the special operation,” Peskov said.


text:
Wellspring Living and Child Advocacy Center of Georgia Partner to Serve Minor Sex Trafficking Victims Across Georgia
Hear from Federal Government representatives, researchers, and service providers about how COVID-19 has impacted the occurrence of domestic violence across the country as they cover—
- an analysis of domestic violence calls,
- the inequities experienced by underserved populations, and
- the challenges service providers experienced and their innovative responses to help those in need.
OVC and the Office on Violence Against Women hosted this webinar on Friday, October 29, 2021.
The Louisiana Child and Youth Trafficking Collaborative Accessibility Initiative: A statewide project to create an equitable and accessible care coordination model for all child and youth victims of human trafficking in Louisiana
Breaking Down Barriers: A Multidisciplinary Team Approach to Strengthening Californiaâs Elder Justice System
Who Are Underserved Victims of Domestic Violence and Sexual Assault? Underrepresented Victim Populations and Barriers to Service Seeking
Serving the Underserved: Providing Victim Advocacy to Cold Case, Homeless, and Refugee Sexual Assault Victims
Crime victim services are not always readily accessible to or designed for victims from all communities. The center is a one-stop shop where victim service providers, culturally specific organizations, criminal justice professionals, and policymakers may get information and expert guidance to enhance their capacity to identify, reach, and serve all victims, especially those from communities that too often have less access to healing services and avenues...
- Nine Counties of the San Francisco Bay Area
Trauma-Informed Transitional Housing and Supportive Services for Victims of Human Trafficking in Mississippi
- 17 Southeastern Counties of Mississippi, including Hancock, Harrison, Jackson, Pearl River, Stone, George, Covington, Forrest, Greene, Jasper, Jefferson Davis, Jones, Lamar, Marion, Perry, Smith, and Wayne
- Southwest Ohio
- Central and Western Massachusetts
- San Diego County
Port Gamble S'Klallam Tribe Purpose Area 7 Tribal Victim Services Project (OVC), improving services and support provided to survivors
Purpose Area 3B: Increasing Access to Mental Health Services to Traditionally Under-served Victims of Crime - Training and Technical Assistance Goal.
Economic Empowerment and Education Services for Georgia Adult Domestic Human Trafficking Victims Including Underserved Populations
- Atlanta Metro Area

domain: law


text:
Right now I'm using:
Jewel Theif's Thin dagger
combined with other various gear I have a DPS of 79
But If I'm using Sniper's Battle Crossbow I only have 75 dps
So are daggers better than crossbows now? I think that daggers are better because I can also equipt a wing shield.
With wing shield I have 58 armor
But without a wing shield I only have 49 armor.
My current gear is:
Burglars Penguin Snowcap 1 Dex, 1 m/s, 7 armor
Jewel Theif's Thin Dagger 20-20 dmg, 0.6 speed, 7 dex, 2h/s + Wing Shield of Ahnold 6 str, 2% dodge, 11 armor
Snipers Battle Crossbow 39-53 dmg/ 1.0 speed, 7 dex, 3% crit, 2h/s, 2 armor
Snipers Bone Tunic 7 dex, 3% crit, 2h/s, 31 armor
So, i guess using a dagger is clearly the better option. The only thing good that happens when you are using a bow/crossbow is that you don't have to be right next to your enemy to attack them, but that doesn't really affect me that much. What do you guys think?


Activity based intelligence (ABI) requires access to all available sources of data. Recorded Future allows analysts to observe structured data on the open, deep, and dark web.
|Is this capacitor? P1330 VENT?||5||70|
|Monitoring temperature and humidity in server room||6||51|
|Using higher voltage laptop charger/adapter is a safe solution.||8||68|
|Plugged in SCSI cable attached to tape-drive cluster, rebooted, now Windows won't boot. Server 2008 R2||6||70|
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Jobst Active Knee High 15-20mmHg Compression Socks
JOBST Activewear socks are designed for men and women who lead active lifestyles and want comfort and style in their compressionwear.
The knee high sock feels like cotton and keeps your feet dry as it uses Dri-Release® technology. Dri-Release® yarn delivers moisture wicking properties without sacrificing softness and comfort. Dri-Release® yarn contains polyester, nylon, and a combination of cotton and spandex elasthan. The benefits of Dri-Release® are that it dries four times faster than cotton, keeping you dry and comfortable, is soft to touch and is environmentally friendy without harmful chemicals.
To determine your size please measure around your ankle and the thickest part of your calf then refer to the JOBST sizing chart below.
Benefits of JOBST Activewear knee high compression socks
- Dri-Release® moisture wicking technology for all day comfort
- Available in 2 colours - black and white
- Suitable for men and women
- Energising compression for your legs to reduce swelling and discomfort
- Soft cotton feel yarn for all day comfort
- Seemless toe for comfort
- Reinforced heel resists abrasion and promotes durability
- Comfortable knee band keeps socks up without pinching
- Designed for easy donning for those with reduced dexterity
Machine wash in lukewarm water. can be tumble dried on low heat.
Do not bleach, dry clean or iron
There are no reviews for this product yet. Please write a review here.


AGA Little Wenlock Multifuel / Woodburning Stove
AGA Little Wenlock is a small but highly versatile stove with an output to rival larger stoves. The compact design ensures it will fit easily into smaller spaces, making it ideal for small rooms and apartment living. The Little Wenlock combines a contemporary looking clear glass window with traditional moulded detailing, the arched side panels and distinctive wire handle make it a must buy AGA stove.
- Heat output 5kW
- Controllable heat output
- Airwash system for cleaner glass
- Longer lasting high chrome grate
- Top or rear flue outlet
Stove Body Material Cast Iron Stove Body Warranty 5 Year Parts Warranty None Heat Output 5kW Flue Size 125mm (5″) Flue Options Top or Rear (Interchangeable) Width 390mm (15.35″) Height 535mm (21.06″) Depth 380mm (14.96″) Height to Centre of Rear Flue 445mm (17.52″) Depth From Back to Centre of Top Flue 125mm (5″) Efficiency (%) 79 Weight (kg) 65


text:
Valley Suites And Extended Stay
Harrisonburg, VA 22801
Rates Recently Found: ($72.00 - $72.00)
Quirky Tourist Attractions in or near Virginia
While in Virginia, you might enjoy a visit to:
On scheduled "fry days," see potatoes fashioned into potato chips.
Dazzling show cave, with famous Fried Eggs formation and tunes played on the giant "Stalacpipe" Organ. Largest cave in the Eastern U.S., measured by airspace. One-hour tour.
Ex-frat boy dies romantically in battle, gets a statue that would make any frat boy cringe.
For those who still remember the TV series. Schuyler is the home town of the guy who wrote the Walton's books (and narrated the shows). His name was Earl, not John-Boy.
© RoadsideAmerica.com, Doug Kirby, Ken Smith, Mike Wilkins. Information provided as an unofficial resource on attractions as a convenience to our visitors.
Harrisonburg Hotel ChainsCandlewood Suites
Country Inn & Suites
Courtyard by Marriott
Holiday Inn Express
Microtel Inn & Suites
Cities Near HarrisonburgFishersville
Airport - TransportationShenandoah Valley Regional Airport (SHD)
Hospitals & Medical Care FacilitiesRockingham Memorial Hospital
Universities & CollegesEastern Mennonite University
James Madison University
Most Desired Travel Destinations:New York, NY
San Antonio, TX
San Diego, CA
Los Angeles, CA
San Francisco, CA
Saint Louis, MO
Kansas City, MO
New Orleans, LA


text:
Prostaglandin receptors EP and FP are regulated by estradiol and progesterone in the uterus of ovariectomized rats.
ABSTRACT: Prostaglandins are important for female reproduction. Prostaglandin-E2 acts via four different receptor subtypes, EP1, EP2, EP3 and EP4 whereas prostaglandin-F2alpha acts through FP. The functions of prostaglandins depend on the expression of their receptors in different uterine cell types. Our aim was to investigate the expression of EPs and FP in rat uterus and to identify the regulation by estradiol, progesterone and estrogen receptor (ER) selective agonists.We performed four different rat experiments involving treatments with estradiol, progesterone and ER agonists. Real-time PCR and immunohistochemistry were employed to evaluate receptor expression.Our results showed that all mRNAs and proteins of EPs and FP are expressed in the rat uterus. The expression pattern and intensity of immunostaining vary between different cell types and treatments. The mRNA expression of all EPs and FP are downregulated by estradiol and the ERalpha specific agonist PPT, whereas the ERbeta specific agonist DPN downregulates only EP2 and EP4. The protein expression however, showed an increase in EP2 and EP3 after estradiol treatment. When treated with estradiol and progesterone in combination, the expressions of EP1 and EP3 are upregulated.Regulation of EPs and FP expression by estradiol appears to be mainly modulated via ERalpha for EP1, EP3 and FP, while EP2 and EP4 also are affected by the ERbeta selective ligand. Our immunohistochemical data shows a cell specific regulation of prostaglandin receptors under the influence of ovarian steroids, where EP2 is estrogen regulated in all uterine tissues examined. EP1 and EP3 are upregulated by the combination of estradiol and progesterone. Thus, our observations indicate that estradiol and progesterone regulate the mRNA and protein expression of EPs and FP in a receptor and tissue specific way.
Project description:To investigate the level of expression of prostaglandin receptivity and uptake factors in eutopic and ectopic endometrium of women with endometriosis.Prospective study.Human reproduction research laboratory.Seventy-eight patients with endometriosis and thirty healthy control subjects.Endometrial and endometriotic tissue samples were obtained during laparoscopic surgery.Real-time polymerase chain reaction assay of mRNA encoding prostaglandin E2 receptors (EP1, EP2, EP3, and EP4), prostaglandin F2? receptor (FP), prostaglandin transporter (PGT), and multidrug resistance-associated protein 4 (MRP4); immunohistochemical localization of expressed proteins.Marked increases in receptors EP3, EP4, and FP and transporters PGT and MRP4 in ectopic endometrial tissue were noted, without noticeable change associated with disease stage. An increase in EP3 expression and decreases in FP and PGT were observed in the eutopic endometrium of endometriosis patients in conjunction with the phases of the menstrual cycle.This study is the first to demonstrate a possible relationship between endometriosis and enhanced prostaglandin activity. In view of the wide range of prostaglandin functions, increasing cell receptivity and facilitating uptake in endometrial tissue could contribute to the initial steps of overgrowth and have an important role to play in the pathogenesis and symptoms of this disease.
Project description:The prostaglandin E2 (PGE2) mediates estradiol-induced masculinization of sexual behavior in the rat during a perinatal sensitive period. PGE2 induces formation of dendritic spines on preoptic area (POA) neurons and this synaptic pattern change is associated with the ability to express male sexual behavior as an adult. Whether PGE2 is released from astrocytes or neurons in the developing POA is unknown. To further understanding of how PGE2 induces dendritic spine formation at the cellular level, we have explored the PGE2 receptor subtype mediating this response. There are four receptors for PGE2, EP1, EP2, EP3 and EP4, each having unique but interacting signal transduction profiles. Treatment of newborn female rats with the EP receptor agonists iloprost, butaprost and sulprostone indicated that stimulation of both the EP2 and EP3 receptors significantly increased spinophilin, a protein whose levels positively correlate to the presence of dendritic spines and masculinization of the POA. Use of antisense oligonucleotides against the mRNA for each receptor reveals that either EP2 or EP3 receptor knockdown reduces spinophilin in PGE2- or estradiol-treated females, whereas reducing EP1 or EP4 receptor levels by the same means has a smaller but also significant effect. A developmental profile of EP receptor expression indicates EP1 in particular is elevated for the first few days of life, corresponding to the critical period for masculinization, whereas mRNA levels for the other three receptors remain relatively constant.
Project description:Prostaglandin E2 (PGE2) plays an important role in bone development and metabolism. To interfere therapeutically in the PGE2 pathway, however, knowledge about the involved enzymes (cyclooxygenases) and receptors (PGE2 receptors) is essential. We therefore examined the production of PGE2 in cultured growth plate chondrocytes in vitro and the effects of exogenously added PGE2 on cell proliferation. Furthermore, we analysed the expression and spatial distribution of cyclooxygenase (COX)-1 and COX-2 and PGE2 receptor types EP1, EP2, EP3 and EP4 in the growth plate in situ and in vitro. PGE2 synthesis was determined by mass spectrometry, cell proliferation by DNA [3H]-thymidine incorporation, mRNA expression of cyclooxygenases and EP receptors by RT-PCR on cultured cells and in homogenized growth plates. To determine cellular expression, frozen sections of rat tibial growth plate and primary chondrocyte cultures were stained using immunohistochemistry with polyclonal antibodies directed towards COX-1, COX-2, EP1, EP2, EP3, and EP4. Cultured growth plate chondrocytes transiently secreted PGE2 into the culture medium. Although both enzymes were expressed in chondrocytes in vitro and in vivo, it appears that mainly COX-2 contributed to PGE2-dependent proliferation. Exogenously added PGE2 stimulated DNA synthesis in a dose-dependent fashion and gave a bell-shaped curve with a maximum at 10-8 M. The EP1/EP3 specific agonist sulprostone and the EP1-selective agonist ONO-D1-004 increased DNA synthesis. The effect of PGE2 was suppressed by ONO-8711. The expression of EP1, EP2, EP3, and EP4 receptors in situ and in vitro was observed; EP2 was homogenously expressed in all zones of the growth plate in situ, whereas EP1 expression was inhomogenous, with spared cells in the reserve zone. In cultured cells these four receptors were expressed in a subset of cells only. The most intense staining for the EP1 receptor was found in polygonal cells surrounded by matrix. Expression of receptor protein for EP3 and EP4 was observed also in rat growth plates. In cultured chrondrocytes, however, only weak expression of EP3 and EP4 receptor was detected. We suggest that in growth plate chondrocytes, COX-2 is responsible for PGE2 release, which stimulates cell proliferation via the EP1 receptor.
Project description:Prostaglandin E2 (PGE2) mediates the organization of male rat sexual behavior and medial preoptic area (MPOA) neuroanatomy during a sensitive perinatal window. PGE2 is up-regulated in response to estradiol, and initiates a two-fold increase in dendritic spines densities on neurons. All the four receptors for PGE2 and EP1-4 are present in developing POA, a critical region controlling male sexual behavior. Previous studies explored that EP receptors are involved in PGE2-induction of neonatal levels of spinophilin protein, a surrogate marker for dendritic spine formation, but did not assess behavioral masculinization. Here, we used two approaches, suppression of EP receptor expression with antisense oligonucleotides and activation of EP receptors with selective agonists, to test which receptors are necessary and sufficient, respectively, for the effects of PGE2 on behavior and neuronal morphology. In female rats, neonatal treatment with antisense oligonucleotides against EP2 or EP4 but not EP1 or EP3 completely prevented the expression of adult behavior organized by PGE2 exposure. The effects of ONO-DI-004, ONO-AE-259-01, ONO-AE-248, and ONO-AE1-329 (EP1-4 agonists respectively) were equivalent to PGE2 treatment, which suggests activating any EP receptor neonatally suffices in masculinizing sex behavior. When given alone, not all EP agonists increased neonatal POA spinophilin levels; yet giving each agonist neonatally increased adult levels. Moreover, adult spinophilin levels significantly correlated with two measures of male sexual behavior. The body of evidence suggests that EP2 and EP4 are both necessary and sufficient for PGE2-induced masculinization of sex behavior, whereas EP1 and EP3 provide redundant roles.
Project description:As a downstream product of cyclooxygenase 2 (COX-2), prostaglandin E(2) (PGE(2)) plays a crucial role in the regulation of bone formation. It has four different receptor subtypes (EP1 through EP4), each of which exerts different effects in bone. EP2 and EP4 induce bone formation through the protein kinase A (PKA) pathway, whereas EP3 inhibits bone formation in vitro. However, the effect of EP1 receptor signaling during bone formation remains unclear. Closed, stabilized femoral fractures were created in mice with EP1 receptor loss of function at 10 weeks of age. Healing was evaluated by radiographic imaging, histology, gene expression studies, micro-computed tomographic (µCT), and biomechanical measures. EP1(-/-) mouse fractures have increased formation of cartilage, increased fracture callus, and more rapid completion of endochondral ossification. The fractures heal faster and with earlier fracture callus mineralization with an altered expression of genes involved in bone repair and remodeling. Fractures in EP1(-/-) mice also had an earlier appearance of tartrate-resistant acid phosphatase (TRAcP)-positive osteoclasts, accelerated bone remodeling, and an earlier return to normal bone morphometry. EP1(-/-) mesenchymal progenitor cells isolated from bone marrow have higher osteoblast differentiation capacity and accelerated bone nodule formation and mineralization in vitro. Loss of the EP1 receptor did not affect EP2 or EP4 signaling, suggesting that EP1 and its downstream signaling targets directly regulate fracture healing. We show that unlike the PGE(2) receptors EP2 and EP4, the EP1 receptor is a negative regulator that acts at multiple stages of the fracture healing process. Inhibition of EP1 signaling is a potential means to enhance fracture healing.
Project description:PURPOSE:Nonsteroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 inhibitors (COXibs) inhibit the progression of endometrial cancer, ovarian cancer and cervical cancer. However, concerning the adverse effects of NSAIDs and COXibs, it is still urgent and necessary to explore novel and specific anti-inflammation targets for potential chemoprevention. The signaling of cyclooxygenase 2-prostaglandin E2-prostaglandin E2 receptors (COX-2-PGE2-EPs) is the central inflammatory pathway involved in the gynecological carcinogenesis. METHODS:Literature searches were performed to the function of COX-2-PGE2-EPs in gynecological malignancies. RESULTS:This review provides an overview of the current knowledge of COX-2-PGE2-EPs signaling in endometrial cancer, ovarian cancer and cervical cancer. Many studies demonstrated the upregulated expression of the whole signaling pathway in gynecological malignancies and some focused on the function of COX-2 and cAMP-linked EP2/EP4 and EP3 signaling pathway in gynecological cancer. By contrast, roles of EP1 and the exact pathological mechanisms have not been completely clarified. The studies concerning EP receptors in gynecological cancers highlight the potential advantage of combining COX enzyme inhibitors with EP receptor antagonists as therapeutic agents in gynecological cancers. CONCLUSION:EPs represent promising anti-inflammation biomarkers for gynecological cancer and may be novel treatment targets in the near future.
Project description:Prostaglandin E2 (PGE2) is produced in the skin and is suggested to play a role in the regulation of cutaneous immune homeostasis and responses. However, the multifaceted functions of PGE2 continue to elude our understanding, especially because of the multiplicity of PGE2 receptors--EP1, EP2, EP3, and EP4. While cAMP-elevating EP4 is known to activate the functions of cutaneous dendritic cells (DCs), including Langerhans cells (LCs) and dermal DCs, the role of cAMP-suppressing EP3 in this process remains unknown. Here we demonstrated that an EP3 receptor selective agonist, ONO-AE-248, inhibited chemotaxis and co-stimulatory molecule expressions of DCs in vitro. A suboptimal dose of antigen was sufficient to induce contact hypersensitivity in EP3-deficient mice. Intriguingly, EP3 deficiency did not impair skin inflammation at all when the antigen dose was sufficiently high. EP3 limited the functions of cutaneous DCs only when the antigen dose was low. In contrast to EP4, the observed unappreciated function of EP3 may stabilize the cutaneous DCs to halt the impetuous response to a suboptimal dose of antigen. Taken together, PGE2-EP3 signaling is essential for fine-tuning excessive skin inflammation by restricting DC functions.
Project description:A major immunological response during neuroinflammation is the activation of microglia, which subsequently release proinflammatory mediators such as prostaglandin E(2) (PGE(2)). Besides its proinflammatory properties, cyclooxygenase-2 (COX-2)-derived PGE(2) has been shown to exhibit anti-inflammatory effects on innate immune responses. Here, we investigated the role of microsomal PGE(2) synthase-1 (mPGES-1), which is functionally coupled to COX-2, in immune responses using a model of lipopolysaccharide (LPS)-induced spinal neuroinflammation. Interestingly, we found that activation of E-prostanoid (EP)2 and EP4 receptors, but not EP1, EP3, PGI(2) receptor (IP), thromboxane A(2) receptor (TP), PGD(2) receptor (DP), and PGF(2) receptor (FP), efficiently blocked LPS-induced tumor necrosis factor ? (TNF?) synthesis and COX-2 and mPGES-1 induction as well as prostaglandin synthesis in spinal cultures. In vivo, spinal EP2 receptors were up-regulated in microglia in response to intrathecally injected LPS. Accordingly, LPS priming reduced spinal synthesis of TNF?, interleukin 1? (IL-1?), and prostaglandins in response to a second intrathecal LPS injection. Importantly, this reduction was only seen in wild-type but not in mPGES-1-deficient mice. Furthermore, intrathecal application of EP2 and EP4 agonists as well as genetic deletion of EP2 significantly reduced spinal TNF? and IL-1? synthesis in mPGES-1 knock-out mice after LPS priming. These data suggest that initial inflammation prepares the spinal cord for a negative feedback regulation by mPGES-1-derived PGE(2) followed by EP2 activation, which limits the synthesis of inflammatory mediators during chronic inflammation. Thus, our data suggest a role of mPGES-1-derived PGE(2) in resolution of neuroinflammation.
Project description:BACKGROUND: Eicosanoid receptors are G-protein-coupled receptors playing an important immunomodulatory role in airway diseases. However, there is little information on the expression of these receptors and their link with eosinophilic inflammation in paranasal sinus diseases. We aimed with this study to investigate the tissue expression of leukotrienes and prostaglandin E2 receptors in chronic rhinosinusitis patients and the link of this regulation with eosinophilic inflammation. METHODS: Samples were prepared from nasal tissue of patients with chronic rhinosinusitis without nasal polyps (CRS, n = 11), with nasal polyps (CRS-NP, n = 13) and healthy subjects (Controls, n = 6). mRNA expression of CysLT1, CysLT2, BLT1, BLT2, E-prostanoid receptors (EP1, EP2, EP3, EP4) and sol-IL-5Ralpha was determined by real-time PCR. Concentrations of PGE2, LTC4/D4/E4, LTB4 and sol-IL-5Ralpha were determined by ELISA and of ECP by ImmunoCap. Protein expression and tissue localization of eicosanoid receptors and activated eosinophils were evaluated by immunohistochemistry. RESULTS: CysLT1 mRNA expression was significantly increased in CRS-NP compared to CRS and controls, and CRS compared to controls, whereas CysLT2 mRNA was enhanced in both CRS groups without differences between them. Levels of both receptors correlated to the number of activated eosinophils, sol-IL-5Ralpha, ECP and LTC4/D4/E4 concentrations in the disease groups. PGE2 protein concentrations and prostanoid receptors EP1 and EP3 were down-regulated in the CRS-NP tissue vs. CRS and controls, whereas EP2 and EP4 expression was enhanced in CRS and CRS-NP patients vs. controls. No differences in BLT receptors were observed between patients and controls. CONCLUSION: CyLTs receptors are up-regulated in nasal polyp tissue and their expression correlate with eosinophilic inflammation supporting previous results. Eicosanoid receptors mRNA pattern observed suggests that down-regulation of EP1 and EP3 in CRS-NP and up-regulation EP2 and EP4 in CRS and CRS-NP groups may have some role in the development of the diseases and their regulation may not be directly linked to eosinophil activation but involve post-transcriptional events mainly related to other inflammatory cell sources.
Project description:Prostaglandin E2 (PGE2) mediates many effects of the midcycle luteinizing hormone (LH) surge within the periovulatory follicle. Differential expression of the four PGE2 (EP) receptors may contribute to the specialized functions of each granulosa cell subpopulation. To determine if EP receptors are differentially expressed in granulosa cells, monkeys received gonadotropins to stimulate ovarian follicular development. Periovulatory events were initiated with human chorionic gonadotropin (hCG); granulosa cells and whole ovaries were collected before (0 h) and after (24-36 h) hCG to span the 40-h primate periovulatory interval. EP receptor mRNA and protein levels were quantified in granulosa cell subpopulations. Cumulus cells expressed higher levels of EP2 and EP3 mRNA compared with mural cells 36 h after hCG. Cumulus cell EP2 and EP3 protein levels also increased between 0 and 36 h after hCG. Overall, mural granulosa cells expressed low levels of EP1 protein at 0 h and higher levels 24-36 h after hCG. However, EP1 protein levels were higher in granulosa cells away from the follicle apex compared with apex cells 36 h after hCG. Higher levels of PAI-1 protein were measured in nonapex cells, consistent with a previous study showing EP1-stimulated PAI-1 protein expression in monkey granulosa cells. EP4 protein levels were low in all subpopulations. In summary, cumulus cells likely respond to PGE2 via EP2 and EP3, whereas PGE2 controls rupture of a specific region of the follicle via EP1. Therefore, differential expression of EP receptors may permit each granulosa cell subpopulation to generate a unique response to PGE2 during the process of ovulation.

domain: medical


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Namco Bandai has announced a Western release date for RPG sequel Tales of Xillia 2.
The PS3-exclusive RPG will be released in Europe and Australia in 2014. Which – obviously – means it arrives after the launch of PS4 at the end of the year.
Tales of Xillia 2 is the 14th main release in the Tales series and was released in Japan late last year. It continues the events depicted in the first Xillia game.
Furthermore, those with a save file for the first game on their system will receive some additional free in-game goodies when starting the sequel.
We are extremely happy to bring another piece of the beloved Tales of franchise in Europe and Australasia,” Namco Bandai Europe’s senior VP Olivier Comte stated.
Tales Of Xillia players will be able to fall back into this deep storyline in 2014 with Tales Of Xillia 2, as we will introduce brand new characters and let them experience new gameplay features but also improvements of the first opus battle system.”

domain: entertainment


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1. Create an account.
First thing you need to do is create your own account in order to post advertisements and stay in touch with the Sleeping Stock community and also to gain access to multiple features.
Once you’ve finished creating your account,its time to sell goods/commodities/services you offer to trade and in order to do so you need to post advertisements so that people can notice you.
Note that the prices of the products are to be inclusive of the appropriate tax.
Now sit back,relax and wait for the interested buyers to contact you for the advertisement you have posted and start generating income and building contacts as easy as that.


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The Body Project
The Body Project is a four-session body acceptance intervention that was designed to help adolescent girls and young women resist sociocultural pressures to conform to the thin-ideal and reduce their pursuit of thinness. It is evidence-based and has been shown to decrease propensity for eating disorders and improve body image long-term. This group is for youth ages 13-17 and seeks to help participants recognize unhealthy physical expectations in the media and among peers as well as take steps to improve their view of their own bodies and appearance.
This is a free 4-week program held online. Text Jodi Rushton – 910-518-0598


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Grease opens at Wakeland High School this weekend with lots more high school musical theater contenders on the way!
Remember how exciting it was to follow our high school musical theater award contenders at Dallas Summer Musicals, Lyric Stage and Casa Manana as the best actors and actresses vied for a chance to go to the national high school musical theater awards show, also known as the Jimmys? It got even more thrilling when our own Drew Shafranek was named one of three male finalists and Emily McIntyre took home the Rising Junior award! If you want to follow our talented teen actors at an earlier stage in the competition, there’s a whole bunch of contenders performing on their high school stages (for very modest ticket fees) this weekend. Here’s a look at the fun on the boards for the DSM High School Musical Theatre Awards contenders; there’s lots more listed for next week on their page at Dallas Summer Musicals:
Wakeland High School: Grease Jan. 17-19,24,26 at 7pm, 27 at 2pm
Jack Ryan High School: Little Shop of Horrors Jan. 17-19, 24-26 at 7pm
Richardson High School: Little Shop of Horrors Jan. 17-19,24-26 at 7:30 pm,Jan.20 at2pm
Red Oak High School: Little Shop of Horrors Jan. 18-20
Northwest High School: The Sound of Music Jan.24-26 @7pm, Jan.27 @ 2pm
Lake Highlands High School: South Pacific Jan. 24,25@7pm-Jan.26@2&7pm
Mabank High School: The Music Man Jan.18,19 @7pm, Jan. 20@2:30pm
I caught the last of the four performances of Les Miserables School Edition presented by Imagination Players and KD Studio and I was impressed. As I wrote in my KidBeat column here, I went in wondering how teens and, indeed, kids as young as eight could pull of such an emotionally, spiritually and technically challenging show. And while no one is going to mistake a school edition production for a professional one, I was touched to tears with the feeling and talent spilling over the modest KD Studio stage — all much applauded by the packed house.
Rebecca Spigel made a remarkable debut as Fantine, singing “I Dreamed A Dream” (now also know as the Susan Boyle song) with a passion beyond her years. Note: not only is this Rebecca’s first show, she’s an incoming freshman at Booker T. Washington High School for the Performing and Visual Arts. Definitely someone to watch. Hector Felix also brought emotional depth and quite a bit of power to Marius. Hector, a graduate of Richardson High School is heading to the American Musical Dramatic Academy in New York to pursue a professional career.
This is very much an ensemble piece and blogs are too short to list every deserving performer. But I was also impressed with Sean Fowler’s Jean Valjean (a tough role for a teen, but this young man could explode with the right part), Mallory McDonald Ayliffe’s sweet soprano as Cosette, Ruby Westfall’s poignant Eponine and the impossibly precocious Christian Wikoff as Gavroche. (I really enjoyed Darrell Morris Jr.’s singing as Javert, too, just couldn’t get past his inherent likableness — these kids were all so likable! — in the harsh, bad guy role).
While it’s too late to catch this show, Garland Civic Theatre’s Children on Stage is also presenting Les Miserables School Edition starting Thursday with what looks like another talented cast of young people. I’m just so glad I caught this one (and would love to hear from others who were there!). It was a reminder for me that attending junior theater is a great way not only of supporting kids as they grow as artists (and at affordable prices) but seeing some exceptional talent on the rise.
PHOTO: Cassidy Cocke as young Cosette in the upcoming Garland Civic Theatre’s Children on Stage production opening Thursday


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Emma Dowling, finalist in the 2017 Sydney Eisteddfod Ballet Scholarship. Photo: WinkiPoP Media
Emma Dowling talks about her passion for dance, what she has learned from her experience performing in Sydney Eisteddfod and the solos she chose to perform in The Sydney Eisteddfod Ballet Scholarship Final.
What inspired your passion for ballet?
My passion for ballet grew over several years and as each year passed I started to love it more and more. Once I turned 12 I was invited to do the part time coaching program and this was when I realized that I wanted to become a ballerina. Never once have I doubted my decision to pursue ballet in a full time capacity.
what inspired you to start dancing?
I was first introduced to ballet when I was 8 years old and went to see my sister perform at her end of year concert at the Jane Moore Academy of Ballet. I was totally mesmerized by ballet and knew from that moment on that this was what I wanted to pursue. Before I started ballet, I had already done several years of calisthenics and gymnastics which prepared me well for the discipline of ballet.
YOU CHOSE TO PERFORM AURORA ACT 3 IN THE SYDNEY EISTEDDFOD BALLET SCHOLARSHIP FINAL, TELL US A LITTLE BIT ABOUT THIS PIECE.
Aurora Act 3 is a variation from the ballet Sleeping Beauty, which is my personal favorite. Aurora is dancing for all the guests at her wedding in this solo. I chose this variation because I think it is one of the most traditional classical ballet variations and I feel like a true ballerina when I perform this solo.
Tell us a little bit about the free variation you also performed.
My contemporary piece titled “Broken” solo starts with the dancer portraying their vulnerability and almost shame to a degree. Many people experience these feelings but it is especially evident in adolescent and young adult females. The solo pushes the dancer to break out from this mentality and find strength and reflection to reconcile with these negative feelings and find self acceptance.
Which other performers do you most like to watch, and why?
I would say Marianela Nunez is definitely one of my favorite ballet dancers to watch. She is such a beautiful performer with amazing skills and technique. One of my favorite qualities about her is the way she gives the perfect personality to each character she dances, it really takes you into the story of the ballet.
What is the best piece of performance advice you've ever heard?
One of the teachers from my ballet school, Miss Claire, always tells us to remember that dancing is about giving out. You still need to dance for yourself of course, but you need to share the story, your feelings and energy with the audience. She always tells us that the best performers are the ones that are generous with their dancing and really connect with the audience.
What have you learnt from your Sydney Eisteddfod experience?
The most important thing I’ve learnt from my experience at the Sydney Eisteddfod is to not doubt myself. The older I get and the more I perform, the more confidence I build for my performances. One of my struggles is probably how I doubt my ability, and I feel that this competition was the first time I just gave my all and totally went for it! I left my fears and doubts behind me and that really helped me to get as far as I did.

domain: artistic


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2 Окт 2012 Mikalar 0
Film Details. Also Known As. Das ausschweifende Leben des Marquis de Sade, Der Marquis de Sade. MPAA Rating. Genre. Biography. Release Date. Jan Marquis de Sade's Justine yify torrent magnet, - Marquis de Sade's Justine () yify movies By YTS - Story: Without a family, penniless and separated. De Sade: Directed by Cy Endfield, Roger Corman, Gordon Hessler. With Keir Dullea, Senta Berger, Lilli Palmer, Anna Massey. A fictionalized biography of the. HOW TO MAKE INTRO WITH AFTER EFFECTS CS6 TORRENT Pros: Free, stable, are also "parameters" files each time Bristol City Stoke can switch between the virtual desktop linked to remote. The line that. For example, how. It will automate in the Policies.
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Corman later claimed that AIP did not pay him what he felt he was owed for his work on the film, contributing to him leaving the company. In real life, Sade was meant to be baptized with the name Donatien-Aldonse-Louis; neither of his parents were present at the ceremony, and the name Donatien-Alphonse-Francois was given to him in error. In his life, he used a number of pseudonyms and variations on his true name.
During the French Revolution , he called himself simply "Louis Sade. Vincent Canby of The New York Times wrote that the film "is not quite as silly as it looks and sounds, but it comes very close. It successfully reduces one of the most fascinating figures of world literature to the role of not-so-straight man in a series of naughty tableaux vivants.
And there is nothing shown or even suggested that is terrible enough to jail a man for life. Samuel Z. Arkoff of AIP said in that the film was his company's biggest flop to date. It has never been released on CD. A novelization of Richard Matheson's screenplay was written by Edward Fenton under the pseudonym he almost always employed for media tie-in work, Henry Clement.
It was released by Signet Books in September Ironically, under his own by-line, Fenton was best known as an author of books for children. From Wikipedia, the free encyclopedia. Release dates. Running time. American Film Institute. Retrieved May 8, Internet Movie Database. August 27, Retrieved March 18, Kings of the Bs : working within the Hollywood system : an anthology of film history and criticism. The New York Times.
October 1, Chicago Tribune. Los Angeles Times. Part IV, p. The Washington Post. The Monthly Film Bulletin. Rotten Tomatoes. Richard Matheson. Richard Christian Matheson son Chris Matheson son. Films directed by Cy Endfield. Roger Corman. Pteracuda Sharktopus vs. Whalewolf Death Race Categories : films English-language films s biographical drama films s erotic drama films s historical drama films American films American biographical drama films American erotic drama films American historical drama films West German films German biographical drama films German erotic drama films German historical films s English-language films English-language German films Films directed by Cy Endfield Films directed by Roger Corman Films directed by Gordon Hessler Films with screenplays by Richard Matheson Films about the Marquis de Sade Films set in France Films set in the 18th century Films shot in Bavaria Films shot in Berlin American independent films American International Pictures films German independent films Films shot at Bavaria Studios Films shot at Spandau Studios independent films drama films BDSM in films.
Connections Edited into Twisted Sex Vol. User reviews 11 Review. Top review. Very dull mix of arthouse and exploitation. American International Pictures rarely made dull movies. Their movies may have been junk food but they were very tasty. This was AIP's attempt at a thinking man's exploitation film. Lavish sets, Masterpiece Theater dialogue and an overall air of pretentiousness makes this film a real snooze.
The fact that the film uses a fractured non-narrative structure makes the film even more pointless and boring. Only during the last 15 minutes does the film come to life as De Sade and his cohorts embark on an orgy of destruction and sex rendered in hilariously psychedelic 60s fashion. Eegah Guy Jul 20, Details Edit. Release date August 27, United States. West Germany United States. Das ausschweifende Leben des Marquis de Sade.
Box office Edit. Technical specs Edit. Runtime 2 hours. Related news. Contribute to this page Suggest an edit or add missing content. Top Gap. By what name was De Sade officially released in Canada in English?
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Delta has now become the dominant variant in US Covid cases, says the CDC
The Delta variant comprises the majority of new US Covid-19 cases for the first time, according to data from the Centers for Disease Control and Prevention (CDC).
Cases of the Delta variant outnumbered cases of the alpha variant for the first time for the two-week period ending on July 3, making up approximately 51% of total cases. This is a sizable rise from approximately 30% of new cases, as was reported by the CDC for a two-week period ending on June 19.
“The transmissibility is unquestionably greater than the wild-type SARS-CoV-2, as well as the alpha variant. It is associated with an increased disease severity, as reflected by hospitalization risk, compared to alpha,” White House health adviser Dr Anthony Fauci warned in a press conference last month.
Health officials have been increasingly warning the public about the Delta variant, arguing it is highly transmissible and vaccinations are still the best way to combat new spikes due to the variant. Studies have shown the Pfizer vaccine to be effective in preventing severe cases with the variant.Also on rt.com Biden seeks to get more Americans vaccinated by taking message ‘door-to-door’ & mobilizing ‘Covid surge response teams’
The Delta variant was first discovered in India and has now popped up in more than 100 countries.
President Joe Biden has warned about the delta variant – which is more transmissible than the alpha variant, according to a World Health Organization (WHO) report citing studies observing a 55% increase in contagiousness – in his numerous pushes to get more Americans vaccinated.
The US is on track to hit 160 million Americans vaccinated in the coming days, according to officials, but there remain over 1,000 counties in the country that health officials have identified as having vaccination rates lower than 30%. This presents the potential for spikes as the country reopens, CDC Director Dr Rochelle Walensky told reporters last week.
Biden had originally set a goal of 70% of US adults receiving at least one jab of a vaccine by the Fourth of July holiday weekend, but that goal was missed – 67% of Americans have at least one jab. The president has announced new expanded efforts to get people vaccinated, including going “door-to-door,” a comment that raised alarm with critics.
“Now we need to go to community by community, neighborhood by neighborhood and, oftentimes, door to door – literally knocking on doors – to get help to the remaining people [to be] protected from the virus,” he told reporters on Tuesday.
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domain: news