Savvy Georgia Tech Awaits Foe For Unexpected Acc Title Matchup
By Dave Glenn and Staff
November 22, 2006
ATLANTA — Georgia Tech coasted home in the Coastal Division.
In relative terms, anyway. While the Atlantic Division came down to the last weekend of the regular season, the Yellow Jackets all but locked up the Coastal a month early.
Tech needed to win only two of its last three ACC games — against the league’s…
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U.S. automotive sales this year are likely to come in at around 14.5 million units, significantly below last year’s volume. With so much pressure on the industry, auto manufacturers will target multicultural consumers to build business. The COVID-19 pandemic isn’t the only cause of market pressures. This week, Ford announced a new CEO will steer the company this fall who acknowledged that technology is a key factor in disrupting the industry, especially from Amazon, Tesla, Apple and Toyota. Automotive ad trends are also changing. One that many dealerships are focusing on is spotlighting multicultural consumers.
Automotive Ad Trends: Targeting Multicultural Consumers
Did you know that “Hispanic, Black and Asian American consumers are aware of 10 to 20% fewer car brands than the general population.” Even more importantly, multicultural consumers account for nearly 40% of the U.S. population. New Nielsen research shows that these consumers are influenced by different types of advertising that automotive ad creators should pay attention to.
Hispanic consumers are tuned into digital advertising. In general, these consumers are younger and pay close attention to their mobile phones. Hispanic shoppers also over-index for having great recall regarding automotive ads they hear on the radio or see in outdoor advertising.
Black consumers listen to radio ads. But they also recall radio and out-of-home advertising. Researchers found that Black consumers who watch six or more hours of TV every day consider 5.5 brands, which is more than the 4.9 brands that all Black consumers consider.
And for Asian Americans, print ads and social media make a difference in their purchase path. TV is the top source of automotive ad recall for 73% of Asian American consumers. However, print is second, at 40%, for these consumers. At the time of purchase consideration, Asian Americans who spend four or more hours a day on social media check out 4.6 automotive brands before they make their final decision. And for Asian Americans who spend more than six hours a day online, the number of automotive brands considered jumps to 5.5.
When it’s time to go car shopping, consumers, on average, check out 3.6 brands. By race and ethnic group, here’s how the numbers break out:
- Non-Hispanic White 3.5
- Black 4.9
- Hispanic 5.1
- Asian American 3.3
There’s an interesting discrepancy in the Nielsen data. While multicultural consumers are aware of fewer brands than white consumers, they consider more brands when they’re actively in the purchase funnel. Your automotive ad clients can successfully target multicultural consumers by paying attention to the media formats they use and by buying ad space in those formats.
Media Mix and Automotive Advertising
In general, here is what new car shoppers say about media influence and recall regarding automotive advertising:
- TV 84%
- Print 29%
- Digital 20%
- Radio 13%
- Out-of-home 10%
- Direct mail 9%
If your auto dealers haven’t been adjusting their media mix, start a conversation with them now. You can show them where consumers live, by zip code, in your local market, by reviewing the consumer demographic data that’s available in AdMall from SalesFuel.

domain: news


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Drew Barrymore used to be “scared” of aligning herself with feminism when she was youthful.
Through the years, the 50 First Dates star has not solely carved out a profession for herself as an actress and producer, but in addition discovered success as a cosmetics entrepreneur along with her firm Flower Magnificence.
However though Drew might seem to epitomise a feminist, she has now shared that she took a very long time to get to grips with the concept, and now helps causes that genuinely empower ladies.
“I was a bit scared of feminism when I was younger because of all the male bashing,” she mentioned in an interview with U.Ok. Glamour journal. “And there are a lot of women’s movements now that I’m apprehensive about, because I don’t want to be viscerally angry at men. I love men. I like keeping both sides in mind. I avoid anything political, where I sense too much anger. It’s just not the way I find messaging to be truly empowering.”
Drew went on to clarify that she plans to instil related messages in her daughters Olive, six, and Frankie, 4, who she shares with ex-husband Will Kopelman.
And as Olive is now across the similar age she was when she appeared in blockbuster film E.T., the star mirrored on the recommendation she would give herself as a toddler.
“I would try to tell her how everything’s going to be O.K. ¬– but she just won’t know it till she’s there anyway,” the 43-year-old famous.
In the meantime, Drew is gearing up to seem in her forthcoming comedy function The Stand-In, the place she performs a disaffected comedy actress in addition to her formidable stand-in.
Regardless of tackling two roles, the Hollywood veteran is up for the problem, particularly as she typically ponders what it could be like to swap identities with different individuals.
“What I’m saying is, I’m stuck here unless I want to move into a bomb shelter. So, I’ve made peace with this,” she sighed in a recent chat on The Late Show with Stephen Colbert. “However, there is a secret side of me that would totally love to (shoot off) and go through life not knowing what any of this is like. So, maybe this is my chance.”

domain: celebrity


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In a statement issued by the State Department Sunday, hours after news broke that ISIS mastermind Abu Bakr Al-Baghdadi died in a U.S. raid, Secretary of State Michael Pompeo called it a “great day for (the) United States, the Global Coalition to Defeat ISIS, and people all across the world who have suffered far too long from the cruelty of terrorism.”
Al-Baghdadi was killed during a U.S. Special Operations Forces raid in northwest Syria Saturday night, according to reports.
The operation reportedly lasted two hours.
President Donald Trump confirmed Al-Baghdadi’s death and said he died “in a vicious and violent way, as a coward, running and crying.”
“He died like a dog, he died like a coward,” Trump said Sunday morning, describing Al-Baghdadi’s final moments as he was whining at the end of a tunnel.
According to sources, the ISIS leader set off an explosive vest as U.S. Special Operations Forces stormed his compound in the Idlib Province.
“While there is still work left to do to ensure ISIS’s enduring defeat, Baghdadi’s death follows the path of scores of other ISIS leaders that have been removed from the battlefield and can no longer commit heinous atrocities or spread their vile ideology of hatred to poison and recruit vulnerable minds,” Sec. Pompeo said.
“His evil acts of beheadings, enslavement of women, rape, torture, and pure brutality follows him to his grave.”


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Getting holiday rentals for food festivals might be a fairly new practice, but some food lovers seriously need information on where they can get housing. Food tasters and food enthusiasts are supposed to know where to find this information.
Renting food and leisure sounds strange, but the fact is that there is a certain percentage of the population that participates in tours and festivals that need information. This is just a guide to help you organize the information you can get online and offline.
Seasonal food fairs and festivals
There are many seasonal food fairs and festivals in the United States that focus on local and renowned delicacies displayed at their fairs or exhibitions. Most food tours or exhibitions are funded by manufacturers who want to promote their products or travel agencies who want to serve a more unconventional crowd. You can compare the concept with a wine club and wine tasting, but instead of spirits, you can try local specialties.
In addition to the usual walking food tours in singapore, there are other food trips that you should try if you are an avid fan. Most of the exhibitions and functions or even fairs that take place in the city, as a rule, have a food tour among their participants. This is one of the marketing strategies of some existing companies: food tours and vacation rentals are related concepts, something new for the tourism industry.
Understand concept of vacation rental
And this concept of vacation rental, which accompanies trips to different countries, is not completely new, as some of the most delicious dishes belong to the same region with a certain ingredient that can grow only there. It can be herbs or spices, or just a way that part of the fauna can contribute to the overall taste of the dishes. As if you are going on a trip to Italy for some pasta, Italian chefs will prepare a characteristic pasta from their own set of wheat and flour. The taste can be very different from the usually packaged products in the supermarket aisles. That is why many people always try to find some kind of food experience to warm up their appetite and make their taste buds more cultured, and that their culinary experience is what they want to repeat again and again.
First things first, you have to decide what kind of food you would like to evaluate to determine rental options in this region. If you decide to become an Asian, for example, in Singapore, you may find that rented villas are the best alternative for organizing food tours and group enthusiasts.
Taking into account the image and taste, you must make sure that you can decide what services you want to rent. Always look for legitimate offers on popular and highly qualified sites. Double-check and enjoy snacks.

domain: food


text: Did you know that you can do an Easter Egg hunt through Disneyland, California Adventure, and Downtown Disney? This is the fifth year this event has been taking place and it is definitely a fun adventure to add to your family's vacation if you are going to be in the parks April 1-16. It's easy to do and you can fit it in between your normally scheduled rides and entertainment. Here's how it works: You can participate by picking up a map and stickers ($5.99 + tax) at any of the participating merchandise locations throughout the Disneyland Resort. Then you will look for Pixar and Disney themed "eggs". You can show where you found each egg by placing the corresponding sticker near that location on the map. (You do not actually pick up the eggs and take them with you). You can choose to find all of the eggs, a few of them, or none at all. Either way, you can turn your map in to a redemption location and get a prize for participating. The following places are where you can turn in your map: Elias & Co in California Adventure, Disney Showcase in Disneyland, and the World of Disney Store in Downtown Disney. If you're going to be there over those dates, you might as well try it out. We are pretty excited to play along!

domain: entertainment


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Monday, March 5, 2012
ROMANTIC FLASHBACK: TONY AWARD WINNING SINGER'S FALLING IN LOVE SONG
1986 CAPITOL RECORDS
From the late 1970's, Tony award singer/actress Melba Moore had become a household name. She had conqured Broadway by starring in the hit play "Purlie" and scored many dance hits including "You Step Into My Life," "Love's Coming At You," "Mind Up Tonight" and "Read My Lips." She also scored a # 1 hit with former labelmate Freddie Jackson, but hadn't score a # 1 hit on her own, and many fans wanted her to sing a romantic ballad. Well Moore was able to do both with her 1986 ballad "Falling" which not only became a fan favorite, it also became her first # 1 R&B hit and also her signature live performance song, which showcased her ability to sing harmony, and showcase her different ranges. It also contains her hitting a high note for 22 seconds, which gives the classic a romantic feel along with the lyrics, and music which has a nice romantic feel courtesy of the guitar, percussion, keyboards and strings.
Melba Moore recorded a wonderful jam and it still sounds as romantic and beautiful as it did and I know that many couples still play this to set the mood for romance.


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Wide receiver Jordan Matthews can’t wait for the weekend.
When the Eagles face the Tennessee Titans on Sunday at Nissan Stadium, not only will Matthews be playing in his second game since returning to the Eagles, but he’ll also be playing in his first in Nashville since he left Vanderbilt.
“It’s going to be awesome. I can’t wait to go back,” said Matthews, who lives with his wife in Nashville, nine minutes from the university. “Have a great relationship with everybody [at Vanderbilt]. … I just love the city of Nashville, so I’m excited to go back with these guys.”
If you’re headed down for the game, Matthews has some suggestions.
“Go to Monell’s family kitchen,” Matthews said. “Basically you walk in, and no matter if your family can take up a table or not, they’ll put you with people you don’t know. It might be a little different for the Philly folks, but down south it’s how we do it.
“Basically they bring out huge troughs of food, and you always have to pass to the left. That’s like common courtesy down south. So they’ll bring a big thing of corn pudding, pass to the left, get what you want, bang-bang, greens, fried chicken, sweet potatoes — good stuff like that. That’s a really good one.”
If you’re looking to go out for breakfast, set your alarm and head to …
“Pancake Pantry for breakfast. Right by campus,” he said. “I will say this — go super early. The pancakes are still good at 6 a.m. as they are at 12. You come at 12, you’re not going to eat until about 3.”
“There’s a place called Pharmacy Burger,” he said. “It’s in east Nashville. It’s a bunch of vegans out there, but they’re cooking this meat up. It’s crazy. I’m a big burger guy. I feel like a lot of people can do meat, but the bun can make or break a burger. They bake the [bread] right beside it. Pharmacy Burger’s amazing. There’s a little taco place that’s right next to it that’s pretty good.”
If you’re on a date …
“For dinner, City House. Italian, but they’ve got an American feel. They change the menu every week or so. Really good. I’m telling you, you want to try this place out.
“That’s a tourist thing,” he said. “I’m an athlete. I’ve done it before … but I can’t be eating that all the time.
“If you want to do the tourist thing, go check it out.”
As much as he loves Nashville, Matthews is happy to be back playing football in Philly. After signing with the Eagles last Wednesday, he played Sunday against the Colts, logging 33 snaps and making two receptions for 21 yards.
Matthews hadn’t trained much over the summer; he was released by the Patriots on Aug. 7.


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domain: geography


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Kantha Shapes Bag Clip
- Holiday special: free domestic shipping on $25 and up!
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A strand of seven Kantha textile beads in different shapes, sizes, and colors is finished with a fringed Kantha tassel. Great for adding a pop of color to your favorite bag or keychain. It's made with recycled kantha, a traditional Indian textile, accented with brass beads and a vegan leather band. Each is one-of-a-kind and will closely resemble but not match the images shown.
- Approximately 8" long
- Handmade by women artisans in India who are changing their lives and communities through fair trade.
- Each comes with a tag that explains the materials and origin, ready for gifting.

domain: artistic


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We know now or should know by now that Lycopene in tomato sauce has been found to reduce the risk of prostate cancer. Now there is a new sidekick here to help. Yeaup…Oregano.
ScienceDaily (Apr. 24, 2012) — Oregano, the common pizza and pasta seasoning herb, has long been known to possess a variety of beneficial health effects, but a new study by researchers at Long Island University (LIU) indicates that an ingredient of this spice could potentially be used to treat prostate cancer, the second leading cause of cancer death in American men.
I must add that dairy from milk, cheese, yogurt and butter all increase the risk of prostate cancer.
So maybe next time you order some pizza you will switch to lots of veggies, tomato sauce, oregano and garlic over fatty heart clogging cheese. If your concerned about calcium stick to green leafy foods or foods that grow in n the ground because that is where the cow gets its calcium.

domain: biology


text: A very Happy Valentine’s Day to you! We’ve had a great week of fun festivities and crafting! We also had some mother / daughter baking time! And of course, we made some Valentine’s Day cookies! Sugar Heart Sandwich cookies, to be exact! A basic sugar cookie with a little pizazz! So yum! I used a strawberry pomegranate juice for the filling. Not only did it give it a pinkish hue but it also added some extra flavor. These were definitely a hit. Hope you have a wonderful day and you feel some love!


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Smartphones Became More Popular than Basic HandsetsAdded: Tuesday, August 27th, 2013
Category: Bit Torrent Freedom > The Industries Of Records, Gaming, Software, Movies
Tags:ET, p2p, Torrent, Piracy, Peer To Peer, Network, Hackers, Internet, BitTorrent, Google, utorrent, bitcomet, extratorrent, www.extrattorrent.com, 2013
Smartphones have for the first time outsold more basic handsets worldwide. It was noticed that demand for the high-tech devices grew in the Asia-Pacific region, Latin America and Eastern Europe. The statistics show that handset manufacturers sold 435 million mobile phones in the 2nd quarter of 2013, with 225 million of them being smartphones.
While the telephone is replacing laptop and desktop computers in access to the worldwide web, it is no surprise that sales to end-users of smartphones grew 74% compared to the same period 2012 in Asia-Pacific, 56% in Latin America and 32% in Eastern Europe. Overall, smartphones accounted for almost 52% of mobile phone sales, thus surpassing feature phone sales for the first time ever.
As for the market leaders, Samsung reinforced its leading position – the company sold more than 71 million Internet-enabled phones in the 3 months to 30 June 2013. Last year it was only 56 million. Overall, Samsung’s market share by units sold increased from 30% to 32%, while Apple’s market share fell from 19% to 14%, though its sales increased from 29 million to 32 million.
Another popular smartphones manufacturer appeared to be Lenovo – the Chinese company well-known for making PCs. The tech giant made its determined push into mobile market by more than doubling its unit sales. In the meantime, Lenovo still relies heavily on its home market, as its sales in China represent 95% of the total.
Then, Sony’s popular Xperia smartphone range helped the company sell more than 2 million more phones – both smartphones and basic devices – than in 2012, expanding its market in mobiles to 2.2% from 1.7%. Although Huawei sold 1 million more devices, its all-mobiles market share remained at 2.6%.
The Finnish giant Nokia retained its position behind Samsung as the 2nd largest manufacturer in the world, but its market share is now 14%, behind Samsung’s quarter of the whole market. In the meantime, Microsoft has finally overtaken BlackBerry among the most popular smartphone OS, largely due to increased sales of Nokia’s Lumia range using the Windows Phone OS. So, Microsoft’s share increased to 3.3% from 2.6%, while BlackBerry’s high-profile relaunch, with the first devices running on its improved BB10 OS, largely failed to halt its decline. As a result, BlackBerry’s market share fell twice.
August 27th,2013Posted by:
Tuesday, August 27th, 2013
|posted by (2013-08-29 05:43:55)|
|Go Samsung! i only buy their products nowadays, TV, tabs, phone (although i also have an iphone5), Having been a primary Nokia consumer... I like how Samsung looks and feels, it is also lighter than any Nokia device, iphone may be even lighter than both but has sharper edges, I plan to get galaxy 5 when it comes out.|
|posted by (2013-08-29 07:51:00)|
|ill agree with tabs phone.,not TV.|
|I also Agree with You SaM..|
|the world's moving too fast and for sites that still not responsive for mobile devices ,it'll be harder for them to stay on the track of the hard competition|
|What about Motorola's sales?|
|Well if you can get a nice smartphone on contract with no money up front why would you get a basic handset on a similar price contract? Hence the increase in smartphone sales as contracts now come with x amount of data. My favourite is still nokia as they are built to last.|
|posted by (2013-08-30 23:34:15)|
|Apple's a fruit. eat and throw away. Samsung..well...that's the real deal.|
|I don't see the point in the smartphones because all people use them for is to go on social network sites like facebook and that just eats your battery anyway.Nobody uses them to phone or text anymore.||
Most Popular Stories


Victory Monday means passing grades!
Happy victory Monday, Tiger fans! Does it taste sweet and vaguely of pumpkin pie? That .500 feeling? Somewhat like success, but only slightly?
Only joking, of course. It’s always a good Monday when Mizzou is coming off a win, especially when that win, (a) came on the road (b) was against a division rival (c) came amidst injury issues at multiple positions (d) occurred with fewer players than the SEC guidelines dictate... OK, maybe we’ll stop there. Nonetheless, a win is a win is a win!
Like we do every Monday, we’re posting all the postgame grade cards up top. Drop one in the comments if we missed it! This week, the beat writers were generous, but not overly so. After all, the Tigers only won 17-10 and almost let Connor Shaw beat them from the sidelines. Has anyone banished him with some sort of spell yet?
- It’s a subscriber-only grade card from Mitchell Forde at PowerMizzou, so no giving anything specific away. I will say, however, that the grades seem appropriate given the way the game played out.
- It’s all passes from Souichi Terada, though one unit baaaaaaarely scraped by! Bet you can’t guess which one!
- At the Columbia Tribune, Eric Blum took down three major takeaways (yeah, I know it’s not, “grades,” sue me) from Saturday’s game, including some heavy praise for the defense. Blum also wrote in appreciation of Mizzou’s captains Nick Bolton and Larry Rountree III. We’ll just say he’s giving them both passes.
Yesterday at Rock M
- Fighting roster attrition, Mizzou has just enough to win on the road
- SBN Reacts: Mizzou fans are positive even without games
- SEC Recap: Week Nine
- Here’s your weekly Mizzou in the NFL recap:
— Sheldon Richardson continues to make an impact on the Cleveland Browns’ defensive line, logging four tackles and two QB hits in the Browns’ win over the Philadelphia Eagles. Jordan Elliott also chipped in a tackle.
— Terez Hall seemingly has a strangle-hold on a position in the Patriots’ defense, logging four more tackles for New England today.
— The Atlanta Falcons didn’t beat their division rivals today, but it was a good day for Charles Harris, who notched a sack and a pass defended off the edge.
— Finally, in what is quickly becoming a major talking point every Sunday for Tiger fans, let’s check in on our boy Drew Lock.
Xavien Howard intercepts Drew Lock on the opening drive for his NFL-leading 6th INT in 2020 pic.twitter.com/CxyE0QfEt7— Main Team (@MainTeamSports) November 22, 2020
Not, uh... not great. It should be noted, however, that the Broncos ended up winning with Lock compiling 270 yards passing and 23 more rushing. Sure, Drew is on a cold streak right now and the critics are piling on. But let’s take the advice of a local radio talking head here.
Josh Allen first 12 games: 52.8% passing 10 TDs 12 INTs 2074 yards 5 -6 as a starter.— Benjamin Allbright (@AllbrightNFL) November 20, 2020
Drew Lock first 12 games: 58.6% passing 14 TDs 13 TDs 2517 yards 6-6 as a starter.
The Josh Allen you see now is 3 years in.
Have patience, and you can be rewarded as the QB grows.
- In addition to the grade card from Forde, Gabe DeArmond wrote up 10 thoughts on the Mizzou win, as he is one to do. Subscribers only, though, sorry!
- Amongst Dave Matter’s notebook on Saturday’s win was a list of players and coaches who didn’t make the trip due to contact tracing issues. On an entirely different note, Ben Frederickson wrote his Sunday column about Mizzou Hoops and the confidence Cuonzo Martin is projecting about his team.
- Souichi Terada was prolific on Sunday. In addition to his grade card, the Kansas City Star beat writer wrote about the defense’s fulfilled promises at the end of the game, in addition to Eli Drinkwitz’s reaction to the team hitting the three-win mark.
- This seems like significant news...
I’m told four-star DB Isaac Thompson plans to visit #Mizzou this week. The St. Louis native has announced a commitment date of Dec. 4, most recently visited Michigan— Mitchell Forde (@Mitchell4D) November 22, 2020
Thompson, a major recruit out of St. Louis, has been trending toward Michigan if you believe in the recruiting sites. However, the Wolverines are struggling mightily and Jim Harbaugh’s seat is getting ever hotter. Drinkwitz is in prime position to pluck a high-major recruit out of his biggest local talent base.
- Drew Buggs is ready to make his one year as a Mizzou Tiger count.
- Speaking of Mizzou Hoops, here’s a lesson for all you future NBAers out there... #MizzouMade guys make money in the Association. Just saying.
Restricted free agent F Jontay Porter has agreed to a three-year, $6M deal to stay with the Memphis Grizzlies, agents Mark Bartelstein and Andy Shiffman of @PrioritySports tell ESPN.— Adrian Wojnarowski (@wojespn) November 22, 2020
Congrats, Jontay! (Editor’s note: I don’t remember the specifics, but #MizzouMade Jordan Clarkson also locked up a hefty deal to return to the Utah Jazz)
- If you’re looking to sign up for ESPN+, Rock M Nation now has an affiliate link: click Here for ESPN+ Now!
- If you’re looking to sign up for a new streaming service, you can try FuboTV: click HERE for FuboTV access — FuboTV now has ESPN, CBS, FS1 and more sports channels.
(** RockMNation has affiliate partnerships. These do not influence editorial content, though RockMNation may earn commissions for products purchased via affiliate links.**)


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All Questions Answered
- What’s your shooting style?
- Being friends to so many beautiful couples like you, we know your wedding day belongs to you and your partner. As good friends, we would never want to steer and direct your beautiful moments. You know we believe real > perfect. We shoot all our films and stills in a documentary style that captures emotions that are non-directed, non-posed and real. This style helps us to tell your story with all the little yet very powerful and magical moments in an authentic spontaneous way.
- What if we want portraits with family and friends?
- Regardless of our style, we know how important these beautiful pictures are to complete your heirloom and so we can’t imagine saying no. We will surely shoot such beautiful photos and if time is right we would also direct you in a flattering pose that will make these photos look natural.
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- We believe that hiring us for our big day is an investment that you make so instead of bundling goods and services in pretty little packages, we want to provide you with the opportunity of getting customised collections. Our basic collection starts from around 3.5 lakhs and it might vary based on many factors like the scale of your wedding, events you want our services for, the services you require, etc. So get in touch with us to get a customised collection for your wedding.
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- We understand the happiness and eagerness of sharing the best day with everyone so we share a few glimpse in 3-4 days of your wedding. Having said that, being your friend, your wedding is very close to us and so are all the other weddings we cover for other friends. All the weddings have special story and we in our wildest dreams can’t imagine outsourcing that to other people. We put our heart and soul in the post processing and make sure of doing justice to all the beautiful stories like yours. Thus the final delivery happens within 6-8 months. We can assure you, dear friend that it’s worth the wait.
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- We would love to be the only friend capturing your wedding. (We are possessive like that ;)) Jokes apart, we shoot in a very unique way and having another team with a different style might cause constraints that would affect the final output.
- Can I have all the RAW data?
- Trust us, having to go through repetitive, unfocused, story-less photos for the entire wedding celebration will not just kill your mood, you’d never want to see them ever again. That’s not what you’ve hired us for. We would want you to have an heirloom that you’d want to visit again and again. So to give the best, dear friend, we would never torture you with all the photos. We would provide you just the best post processed still and films.
- How can we hire you?
- Easy. Just contact us and we will arrange an opportunity to personally connect with you regardless of how we meet whether it be a phone call, a coffee date or online meet. We will just chat and know you, know what you are looking for in regards of our services.


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Rediscovering the first color photographs of North America
These rediscovered Photochrom and Photostint postcard images from the private collection of Marc Walter were produced by the Detroit Photographic Company between 1888 and 1924. Using a photolithographic process that predated the autochrome by nearly 20 years, they offered people the very first color photographs of the United States. Suddenly, the continent’s colors were available for all to see. From the rich ochres and browns of the Grand Canyon to the dazzle of Atlantic City, these places were now a visual delight not only for eyewitnesses but for Americans far and wide.
Imbued with a sense of discovery and adventure, the pictures gathered here are a voyage through peoples, places, and time. They take us through North America’s vast and varied landscape, where we encounter its many communities, and above all transport us back to the United States of over a century ago. Across more than 600 pages including fold-out spreads, this sweeping panorama takes us from Native American settlements to New York’s Chinatown, from some of the last cowboys to Coney Island’s heyday. As luminous now as they were some 120 years ago, these rare and remarkable images that brought America to Americans now bring America’s past to our present.
Hardcover with fold-outs, 612 pages


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This elegant ring is comprised of two sweeping leaf-like shapes that come together to form an X shape in the center. Striking yet minimal, combining natural and geometric forms, it truly is one of our favorites!
Each ring is unique and slightly irregular, giving it a truly handmade, artisanal look. Our signature matte gold finish has an extremely bright, luminous quality and pairs well with all of our gold jewelry.
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Please Sign In. Login or Sign Up now to post a comment! Read more about how to report abuse and violations. Tipping is the best way to show appreciation for your favorite models, and to encourage 'em to make new videos.
Nude Video Leaks Online...
The World's Biggest XXX Porno Tube
Ohio rapper DaBaby nude video has leaked online and the black rapper has responded! We think he is lying, but do not understand the reason, this cock needs to be seen and famous! On December 21st, ugly rapper DaBaby became a trending topic on Twitter after a nude video of a man purported to be the North Carolina MC hit the internet. In the video in question, a man many people on Twitter believed to be DaBaby can be seen from the chest down with his boner exposed. According to the Bop rapper, the video is not him, which means someone may have dubbed his audio with the video. DaBaby said his opinion about the whole situation on Twitter… And disappointed the women around the world. It supposed to be believed into his words, but who knows fellas. Here is the leaked DaBaby naked video.
DaBaby may have the newest victim of nude video and photo leaked online, but a popular porn star is claiming the original video is actually of him. Saturday night a random account posted a short video on Twitter claiming it was a self-shot video of popular rapper DaBaby. The video appears to be a POV shot by the person for the purpose of sending to someone else.


The Christian music industry is a small part of the larger music industry, that focuses on traditional Gospel music, Southern gospel, contemporary Christian music, and alternative Christian music. It is sometimes called the gospel music industry , although this designation is not a limitation on the musical styles represented.
Christian music is supported by a segment of the general music industry which evolved as a parallel structure to the same. Beginning in the 1970s and developing out of the Jesus movement, the Christian music industry subsequently developed into a near-billion dollar enterprise.
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Find images of Christian Music. Free for commercial use No attribution required High quality images.
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Marshmello Joins Avril Lavigne On Nostalgic Pop-Punk Track, “Bite Me”
With additional contributions from Travis Barker and MOD SUN, “Bite Me” is an ode to Lavigne’s early 2000s-era sound.
He may not be a “Sk8er Boi,” but Marshmello sure is a superstar—especially after his recent songwriting work on Avril Lavigne‘s new track, “Bite Me.” Released November 10th, it’s the lead single off Lavigne’s forthcoming seventh studio album, due in 2022.
Featuring angsty lyricism and frenetic drum breaks courtesy of blink-182’s Travis Barker, “Bite Me” is a classic pop-punk anthem that harkens back to Lavigne’s distinctive early 2000s-era sound. It’s tough not to get nostalgic for afternoons spent browsing the racks at Hot Topic and head-banging to the tunes of Sum 41 and Good Charlotte.
Marshmello received a songwriting credit on the single, which also features contributions from Omar Fedi, who is perhaps best known for his work with Lil Nas X and The Kid LAROI. Additional collaborators include Goldfinger lead singer John Feldman and Lavigne’s current boyfriend, MOD SUN, an esteemed pop-punk and alternative hip-hop artist.
“It was just time to rock again, and I have a feisty side to me,” Lavigne said in a recent interview with Zane Lowe of Apple Music 1. “Let’s face it: Love’s not easy, right? And, I mean, I’ve been through the ringer, so yeah I’m writing about it again.”
“It’s an anthem about knowing your worth, what you deserve and not giving someone a second chance who doesn’t deserve you,” Lavigne added in a press release.
View the original article to see embedded media.FOLLOW AVRIL LAVIGNE:
Article Source and Credit edm.com https://edm.com/music-releases/avril-lavigne-marshmello-bite-me Buy Tickets for every event – Sports, Concerts, Festivals and more buytickets.com


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I find it so interesting that a simple geometric cushion or rug, can change a room from traditional classic to contemporary. Or from bland to cleverly designed. With so many new geometric patterns around at the moment why not play with some pattern? Start with some cushions and as you become more adventurous add larger areas in rugs or wallpaper.
images via David Hicks, brown design and all the best.


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Our private Intestinal polyps services are provided at the Hadley Wood Hospital, High Barnet.
To find out more about our hospitals click here:
Intestinal polyps, also known as bowel polyps, are small fleshy growths that can develop on the lining of the large intestine/colon or rectum.
They are very common, affecting around 25% of people at some point or other, and often don’t cause any symptoms. However, larger or multiple polyps may cause symptoms such as blood or mucus in your stools, changes in bowel habits (diarrhoea or constipation) and abdominal pain. The vast majority of intestinal polyps are benign, however certain types of polyps, called adenomas, may develop into cancer. This is rare and usually happens very slowly, but removing polyps is still recommended.
The method used to remove polyps may depend on where in the bowel they are located and how big they are. Smaller polyps are usually removed endoscopically, with a colonoscopy or sigmoidoscopy used to enable the consultant to access the polyp. These procedures involve a special scope being inserted into the colon via the rectum, through which very fine cutting tools can be passed. These are performed as outpatient procedures and don’t require general anaesthetic, so you would be able to go home shortly afterwards. However, larger or more complex polyps may require bowel surgery. In this case, general anaesthetic would be used and you may need to stay overnight in hospital and take time off work to recover.
The polyps will be examined closely in the lab for any signs of cancer or pre-cancerous cells. Also, removing intestinal polyps does not mean more won’t grow in the future, so routine screenings to check for further polyps is generally advised. Your consultant will be able to advise on what’s best for you.
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Michael Lofthouse, the CEO and founder of tech company Solid8, was caught on camera verbally attacking Jordan Chan and her family while they were out celebrating her aunt's birthday.
The incident took place at Bernardus Lodge and Spa's Lucia restaurant in Carmel Valley on July 4 and saw Lofthouse called them a "f***ing Asian piece of s***".
The video was shared widely online, including by pop star Kelly Clarkson, and prompted widespread condemnation.
In the footage, which Ms Chan posted to Instagram on Sunday, Lofthouse appears to have started a tirade against his fellow diners, with the person filming him telling him to "say that again".
Lofthouse remains silent and they can be heard saying: "Oh, now you're shy. Say it one more time."
He responds by holding up his middle figure and adding: "That's what I'm saying now."
As he gets up to leave the restaurant, he says: "'Trump's going to f*** you! You f***ers need to leave."
A waitress then appears to tell him so leave, saying: "Get out of here, You are not allowed here. You do not talk to our guests like that."
But Lofthouse continues with his attack, saying: "You f***ing Asian piece of s**t".
He then turns to the waitress and saying: "Who are these f***ers?" and she replies: "They are valued guests".
He says: "Are they? They are valued guests in America?"
The waitress continues to tell him to "get out' and says: "You are not allowed here ever again".
Ms Chan wrote on Instagram that he had begun harassing her family "unprovoked" soon after they sang happy birthday to her aunt. Aside from the comments caught on camera, she said he also told them to "go back to whatever f***ing Asian country you're from" and "you don't belong here".
She wrote: "This is the face of the man who relentlessly harassed my family and I completely UNPROVOKED, UNWARRANTED, and UNCONSCIONABLE.
"We were celebrating my titaâ€™s birthday, literally just singing happy birthday to her and taking pictures, when this white supremacist starts yelling disgusting racist remarks at us."
Lofthouse, who appears to have deactivated his LinkedIn and social media accounts after the incident, later issued an apology for his "appalling" behaviour.
He told the Daily Mail: 'My behaviour in the video is appalling. This was clearly a moment where I lost control and made incredibly hurtful and divisive comments.
"I would like to deeply apologise to the Chan family. I can only imagine the stress and pain they feel.
"I was taught to respect people of all races, and I will take the time to reflect on my actions and work to better understand the inequality that so many of those around me face every day."
The Bernardus Lodge also said they were sorry about the experience their guests endured at the restaurant.
"This is an extremely unfortunate situation, however, we are proud of our staff at Lucia in keeping with Bernardus Lodge's core values," said Sean Damery, the lodge's vice president and general manager, in a statement to KION.
"This incident was handled swiftly and the diner was escorted off property without further escalation. We provide guests with a safe environment for lodging and dining, and extend our sincere apologies to the guests enjoying a birthday celebration on a holiday weekend."
The Standard has contacted both Solid8 an Bernardus Lodge for comment.


From Here to Infirmary (Vagrant)
by Tim Den
All the hype’s not wasted here. Having heard Alkaline Trio during their infancy, I must say I’m thoroughly impressed by how mature and cohesive they’ve become. They’ve always had that spark of magic buried within their Jawbreaker-ish pop songs, but they’ve refined it this time. The cynical yet sentimental remarks flow effortlessly from one singer to another, as chiseled chords and so-natural-it’s-gotta-be-magic melodies spring forth like they’ve always belonged in your subconscious. It’s as if you’ve always known how great grown-up pop punk can be; Alkaline Trio simply gave flesh to the idea. Finally, a “buzz” band that deserves all the attention they’re getting.
(2118 Wilshire Blvd. #361 Santa Monica, CA 90403)


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Cardiomyocyte Mineralocorticoid Receptors Are Essential for Deoxycorticosterone/Salt-Mediated Inflammation and Cardiac FibrosisNovelty and Significance
Because the role of mineralocorticoid receptors in specific cell types in cardiac remodeling remains unknown, we have compared cardiac responses with deoxycorticosterone/salt in cardiomyocyte mineralocorticoid receptor-null (MyoMRKO) and wild-type (WT) mice at 8 days and 8 weeks. No differences in cardiac function between untreated WT and MyoMRKO mice were found, whereas profibrotic markers were reduced in MyoMRKO hearts at baseline. At 8 days, MyoMRKO showed monocyte/macrophage recruitment equivalent to WT mice in response to deoxycorticosterone/salt but a suppression of markers of fibrosis compared with WT. At 8 weeks, MyoMRKO mice showed no deoxycorticosterone/salt-induced increase in inflammatory cell infiltration and collagen deposition or in proinflammatory gene expression. Although some profibrotic markers were equivalently increased in both genotypes, MyoMRKO mice also showed increased baseline levels of mRNA and protein for the transforming growth factor-β/connective tissue growth factor inhibitor decorin compared with WT that was accompanied by higher levels of matrix metalloproteinase 2/matrix metalloproteinase 9 activity. These data point to a direct role for cardiomyocyte mineralocorticoid receptor in both deoxycorticosterone/salt-induced tissue inflammation and remodeling and suggest potential mechanisms for the cardioprotective effects of selective mineralocorticoid receptor blockade in cardiomyocytes that may involve regulation of matrix metalloproteinase 2/matrix metalloproteinase 9 activity and the transforming growth factor-β-connective tissue growth factor profibrotic pathway.
Clinical and experimental studies have demonstrated the therapeutic potential of mineralocorticoid receptor (MR) antagonists, although hyperkalemia, gynecomastia, and erectile dysfunction limit their widespread use.1 Identifying tissue-specific features of MR signaling that can be exploited for the rational design of cardiovascular-selective MR antagonists may offer cardiovascular protection without compromising renal function.
We and others have shown that MR signaling in the context of high salt (the deoxycorticosterone [DOC]/salt model) leads to inflammation, fibrosis, and ultimately cardiac dysfunction.2 Such remodeling is a direct cardiovascular effect of MR activation rather than secondary to elevated blood pressure.3 Recent studies have identified novel roles for MR signaling in monocytes/macrophages4 and endothelial cells5 in the development of cardiac fibrosis.
Cardiomyocytes express both functional MR and glucocorticoid receptors, but not 11β-hydroxysteroid dehydrogenase 2, thus MR in cardiomyocytes normally act as high-affinity receptors for glucocorticoids.6 In contrast, in epithelial cells (and vascular smooth muscle cells), glucocorticoids do not activate MR because of enzymatic modification by 11β-hydroxysteroid dehydrogenase 2.7 Cardiomyocyte overexpression of MR causes cardiac arrhythmias by 2 months of age, but no change in fibrosis, inflammation, or apoptosis.8 More recent studies using cardiomyocyte MR-null mice show a differential role for cardiomyocyte MRs in remodeling and functional changes postinfarct9 and after transaortic constriction.10 Although loss of cardiomyocyte MR improved infarct healing, scar thickness, and cardiac function in this model, cardiomyocyte MR-null mice were not protected from tissue remodeling, suggesting that the role of cardiomyocyte MR in the progress of cardiac disease may be dependent on the specific cardiac insult.
The aims of the present study were to explore the role of cardiomyocyte MR in the initiation and development of cardiac inflammation and fibrosis, in particular in the regulation of the transforming growth factor-β (TGFβ)/connective tissue growth factor (CTGF) profibrotic pathway. The present study was designed to determine the proinflammatory (membrane cofactor protein-1, C-C chemokine receptor type 5 [CCR5]), oxidative stress (NOX2, p22phox), and profibrotic (TGFβ, CTGF, fibronectin, collagen III [Col III]) cardiac responses in wild-type (WT) and cardiomyocyte MR-null (MyoMRKO) mice, given DOC/salt and investigated at both the initiation of tissue injury (8 days) and once fibrosis is established (8 weeks). We also performed microarray analysis for the identification of additional important inflammatory and fibrotic signaling pathways that may contribute to the translation of cardiomyocyte MR activation into tissue remodeling via known or novel pathways.
Materials and Methods
Additional Materials and Methods are provided in the online-only Data Supplement.
Cardiomyocyte-Specific MR Knockout Mice
All procedures involving animals were approved by the Monash University Animal Ethics and Biosafety Committees. The presence of the MRflox/flox and MLC2v Cre transgene was determined by polymerase chain reaction analysis of genomic DNA from tail tips with the primers listed in Table S1 of the online-only Data Supplement (Figure S1A and S1B). MR expression in cardiomyocytes was determined by immunohistochemical analysis and Western blot as previously described.4
Male MRflox/flox and MRflox/flox/MLC2vCre+/− mice (25–30 g) were uninephrectomized and given vehicle or DOC (Sigma-Aldrich), administered via a subcutaneous pellet (7 mg of pellets/3 weeks), and maintained on standard chow plus 0.9% NaCl plus 0.4% KCl solution for 8 days or 8 weeks. Systolic blood pressure (SBP) was measured by tail-cuff plethysmography at weeks 4 and 8, as previously described (IITC Life Science).4
Radioimmunoassay for Hormone Levels
Aldosterone, corticosterone, angiotensin II, and atrial naturietic peptide were determined in serum by standard radioimmunoassay according to the manufacturers’ instructions (MP Biomedicals).
Assessment of Ex Vivo Heart Function
WT and MyoMRKO mice given vehicle or DOC/salt for 8 weeks (final age, 16 weeks) were anesthetized with sodium pentobarbitone (70 mg/kg, IP). A thoracotomy was performed, and hearts excised into ice-cold perfusion fluid for cannulation and perfusion on a Langendorff perfusion system (expanded Methods in the online-only Data Supplement).
Histological and Immunohistochemical Analyses
Cardiac fibrosis was quantified by Picrosirius red staining (5-μm sections) and digital analysis of systematically sampled sections as previously described.4 Cardiomyocyte cross-sectional area was determined in hemotoxylin and eosin–stained sections, with 80 to 100 cells sampled per heart (n=7 hearts per treatment group) and the cross-sectional area determined directly using Analysis LS Research software (Olympus).
Inflammatory cell infiltration was determined by CD11b immunostaining (Abcam). Immunostaining was also performed for TGFβ1 (1:300; Santa Cruz, Biotechnology Inc), CTGF (1:100; Abcam), fibronectin (1:1000; Santa Cruz Biotechnology), Col III (1:300; Abcam), and decorin (1:100; R&D Bioscience, Sapphire Bioscience Pty Ltd) and the relevant negative IgG used as control. Immunostaining was assessed by 2 investigator blinded to the identity of the samples using a semiquantitative scoring system of 0, +, ++, and +++, where 0 is no staining and +++ is strong staining. Between-investigator variability was calculated to be ≈15%.
Illumina BeadChip Expression Array
An Illumina BeadChip expression array was used to identify oxidative stress, inflammatory, and profibrotic genes not previously characterized in the DOC/salt model and those potentially regulated by cardiomyocyte MR. Gene expression profiles were determined with Illumina BeadChip expression arrays (MouseRef-8 version 2.0 Expression BeadChip; Illumina Inc) performed at the Australian Genome Research Facility on pooled mRNA from each treatment group and genotype. Genes identified by differential expression on microarray and those previously associated with DOC/salt inflammation and tissue remodeling were confirmed by quantitative polymerase chain reaction using primers listed in Table S1.
Matrix Metalloproteinase 2/Matrix Metalloproteinase 9 Activity
Tissue was homogenized with a Qiagen Tissue Lyser and assayed with a Molecular Probes EnzChek Gelatinase/Collagenase Assay Kit (Invitrogen). Total protein was determined with the Pierce BCA Protein Assay Kit (Thermo Scientific) and a total of 70 μg per sample were used. Briefly, samples were made up to a total volume of 200 μL with reaction buffer and 10 μL of DQ fluorescent gelatin, the substrate for gelatinases matrix metalloproteinase (MMP) 2 and MMP9. Twenty micromoles per liter of EDTA was added to separate samples and inhibited MMP2/MMP9 activity by 50% (data not shown). Readings were recorded on the Agilereader (Agilent) with a 515-nm filter at 1, 2, and 24 hours.
All data sets were analyzed by 2-way ANOVA and Bonferroni post hoc test (GraphPad Prism version 5.0a, GraphPad Software). Normal distribution was confirmed by the D’Agostino-Pearson normality test before ANOVA. The mean difference was considered significant at P<0.05. All data are reported as mean±SEM and n=8 to 10 for treatment groups; for semiquantitative analysis of immunostaining, n=5 to 6 per group used.
Cardiomyocyte MR-Null Mice
MLC2vCre/+, MRflox/−/MLC2vCre/+, and MRflox/flox (WT) mice were used to breed MRflox/flox/MLC2vCre/+(MyoMRKO) mice (Figure S1C and S1D); they showed normal fertility. Deletion of the loxP-flanked genomic region of MR resulted in loss of MR expression in cardiomyocytes (Figure S1A and S1B). MyoMRKO mice had a normal phenotype with normal body, heart, and kidney weights; baseline SBP; and plasma aldosterone, corticosterone, and angiotensin II levels within the expected range for mice drinking 0.9% saline NaCl/0.04% KCl (Tables S2 and S3).
Cardiomyocyte MR Signaling, Tissue Inflammation, and Remodeling at 8 Days
Cardiac responses were examined at 8 days to determine whether loss of cardiomyocyte MR influenced the onset of cardiac fibrosis. DOC/salt treatment modestly increased cardiac interstitial collagen deposition above control in WT mice only (Figure 1A). No significant change in MMP2/MMP9 activity was found at this time (Figure 1B), but a significant genotype effect was detected for the increased MMP/tissue inhibitors of metalloproteinase 1 mRNA ratio in MyoMRKO tissue versus WT (Figure 1C). The small change in fibrosis detected at 8 days of treatment was absent in MyoMRKO mice.
A panel of markers for cardiac oxidative stress, inflammation, and remodeling plus novel targets identified from microarray analysis were examined by quantitative polymerase chain reaction (Tables S5 and S6). Gene data sets have been deposited on the online Gene Expression Omnibus. Genes from the microarray selected for further analysis were chosen for their role in oxidative stress, inflammation, and fibrosis. Genes showing significant changes are highlighted and show basal mRNA levels for plasminogen activation inhibitor 1, vascular endothelial cell growth factor A (VEGFa), and VEGF receptor 2 that were significantly lower than untreated WT mice (WT CON) in MyoMRKO hearts (Figure 1D and 1E and Table S6). mRNA levels for plasminogen activation inhibitor 1 (Figure 1D) and Per2 increased in response to DOC/salt in WT but not MyoMRKO hearts (Figure 1F). In contrast, mRNA for Col III and fibronectin was equivalently increased by DOC/salt in WT and MyoMRKO mice (Table S6). The lack of a fibrotic response in MyoMRKO mice is thus accompanied by a suppression of some, but not all, markers of fibrosis and tissue remodeling.
We detected a significant increase in infiltrating monocytes/macrophage number in hearts from both WT and MyoMRKO mice (Figure 2A), consistent with the previously reported primary vascular inflammatory response to DOC/salt administration.4,11 DOC/salt treatment for 8 days significantly increased mRNA levels for T-cell chemoattractant CCR5 and nicotinamide adenine dinucleotide phosphate oxidase subunit NOX2 in WT but not MyoMRKO mice (Figure 2B and 2C). mRNA levels for nicotinamide adenine dinucleotide phosphate oxidase subunit p22phox were lower in untreated MyoMRKO hearts than for WT CON (Figure 2D). These data show lowered oxidative markers and a loss of an innate inflammatory response in MyoMRKO compared with WT mice after DOC/salt treatment.
Cardiomyocyte MR Regulate Cardiac Inflammation and Remodeling at 8 Weeks
Neither genotype nor DOC/salt treatment significantly altered cardiac or renal weight relative to body weight (P=0.7 versus WT CON), nor cardiomyocyte cross-sectional area (Table S3). A marked increase in tissue fibrosis was seen after 8 weeks of DOC/salt administration in WT hearts, but there was a striking lack of fibrosis in DOC/salt-treated MyoMRKO mice (Figure 3A and Figure S2A). MMP2/MMP9 activity was lower in WT DOC compared with WT CON, whereas activity in MyoMRKO DOC was equivalent to WT CON (Figure 3B). The panel of fibrotic and inflammatory markers was also assessed at 8 weeks and showed increased CTGF, fibronectin, Col III, and TGFβ mRNA levels by DOC/salt treatment in both WT and MyoMRKO mice at 8 weeks (Figure 4A through 4C and 4E). The TGFβ1-inhibitory peptide decorin, identified in the microarray screen, was increased by DOC/salt in both genotypes and at baseline in MyoMRKO mice (Figure 4D). In contrast, baseline values for TGFβ1 and integrin-β1 mRNA were significantly lower in MyoMRKO hearts compared with WT CON (Figure 4E and 4F). VEGFa mRNA was significantly elevated by DOC/salt in WT hearts only, whereas values for VEGF receptor 2 did not reach significance (Figure 4G and 4H).
Fibronectin was detected in all hearts in interstitial and perivascular spaces with expression higher in both control and DOC-treated WT mice compared with MyoMRKO mice (Table S4 and Figure S3A). CTGF expression was detected in cardiomyocytes and the vessel wall and increased in response to DOC/salt in WT hearts only (Table S4 and Figure S3B). Vascular expression of TGFβ was not seen in MyoMRKO hearts, but was increased in hearts from DOC/salt-treated WT mice (Table S4 and Figure S4A). Similar to CTGF staining, Col III levels were increase WT mice only by DOC/salt treatment (Table S4 and Figure S4B). Decorin expression was detected in perivascular and interstitial regions in cardiac tissue in all mice and was higher in MyoMRKO hearts regardless of treatment (Table S4 and Figure S5). VEGFa was detected in vessel wall of both genotypes, whereas immune cell expression of CTGF, TGFβ1, and VEGFa showed no change with either genotype or treatment (data not shown).
At 8 weeks of DOC/salt, 3 patterns of responses were found for fibrotic marker expression: (1) suppression at baseline and in response to DOC/salt in MyoMRKO versus WT mice (ie, TGFβ1, integrin β1, and VEGFa); (2) equivalent upregulation in both genotypes with DOC/salt (CTGF, fibronectin, and Col III); and (3) increased basal and DOC/salt-induced expression of antifibrotic factors (decorin) in MyoMRKO versus WT mice. Upregulation of several profibrotic markers at the mRNA level was not reflected in protein expression in MyoMRKO mice.
A marked increase in tissue monocytes/macrophages was detected at 8 weeks of DOC/salt treatment in WT but not MyoMRKO mice (Figure 5A and Figure S2B). Similarly, increased CD45+ leukocyte and CD8+ T-cell numbers were seen in WT mice only with DOC/salt treatment (Figure 5B and 5C). Consistent with these data, baseline mRNA levels were lower in MyoMRKO CON versus WT CON for the chemoattractant proteins membrane cofactor protein-1 and CCR5, monocyte differentiation antigen CD14, and B-cell/T-cell costimulatory antigen CD81 (Figure 5D through 5G). Although mRNA levels were lower in MyoMRKO mice, a significant treatment effect was still detected for membrane cofactor protein-1 mRNA (Figure 5D) but not for CCR5, CD14, and CD81. These data show that loss of cardiomyocyte MR blocks the full inflammatory response to DOC/salt. A difference in inflammatory cell number at 8 days versus 8 weeks reflects the importance of vascular inflammation for early macrophage recruitment and the normal life span (6–16 days) of macrophages.
Cardiomyocyte MR Modulates Ex Vivo Cardiac Function but Not Blood Pressure Responses to DOC/Salt Treatment
Cardiac function was determined at 8 weeks in vehicle and DOC/salt-treated WT and MyoMRKO hearts instrumented on a Langendorff apparatus under aerobic perfusion conditions. Left ventricular–developed pressure was not different between vehicle-treated mice of both genotypes and was not altered by pacing hearts at 420 beats per minute (Table S7). DOC/salt treatment in WT, but not MyoMRKO, mice was associated with a significant increase in developed pressure, also apparent in paced hearts. Rates of cardiac contraction and relaxation assessed by a 2-tailed t test were also increased in WT mice given DOC/salt only (P=0.011 and P=0.012; Table S7). Heart rate and coronary flow (data not shown) were equivalent in all groups. These data demonstrate that loss of MR specifically in cardiomyocytes does not alter baseline cardiac function but that treatment with DOC/salt for 8 weeks promotes a positive inotropic state that is absent in MyoMRKO mice.
DOC/salt treatment for 8 weeks increased SBP in WT mice (Figure S6A). Mean SBP values for untreated MyoMRKO mice were higher than for WT but not significant, with no difference in SBP found for MyoMRKO mice between CON and DOC/salt treatment. Plasma atrial naturietic peptide levels were equivalent in untreated WT and MyoMRKO mice at 8 weeks and were increased only in WT DOC mice (Figure S6B). Eight-week mRNA levels for brain natriuretic peptide were significantly lower in untreated MyoMRKO mice compared with WT; DOC/salt treatment significantly increased values in WT with similar relative change in MyoMRKO mice (Figure S6C). These limited changes in hemodynamic parameters are thus unlikely to account for the marked reductions in tissue fibrosis and inflammation observed in the MyoMRKO mice.
The present study demonstrates a central role for cardiomyocyte MR in both the initiation and progression of DOC/salt-induced cardiac tissue inflammation and remodeling. Although the cardiomyocyte MR is not involved in the initial phase of DOC/salt-induced macrophage recruitment, we have identified a role for cardiomyocyte MR in the sustained inflammatory response at 8 weeks of DOC/salt treatment, in part via regulation of expression of chemoattractant proteins and chemokines. Upregulation of the CTGF-TGFβ1-Col III profibrotic pathway at the mRNA level was not mirrored by protein expression in MyoMRKO mice. This differential response may reflect increased expression of the CTGF/TGFβ1 inhibitor decorin in MyoMRKO mice. MyoMRKO mice also showed higher cardiac MMP2/MMP9 activity compared with WT mice. Protection from DOC/salt-induced fibrosis in MyoMRKO mice may also involve reduced tissue inflammation because of loss of chemokine expression and reduced recruitment of monocytes/macrophages and lymphocytes. Collectively, these data demonstrate an important and independent role for cardiomyocyte MR in the progression of DOC/salt-induced tissue remodeling.
Cardiomyocyte MR and Collagen Deposition
A significant finding of the current study is that DOC/salt-mediated cardiac fibrosis is prevented in MyoMRKO mice. Our data show a parallel change in gene expression in MyoMRKO mice that favors reduced tissue fibrosis at 8 days (reduced plasminogen activation inhibitor 1) and 8 weeks (reduced TGFβ1).12,13 Together with a higher MMP2/MMP9 activity in MyoMRKO mice versus WT, these tissue responses suggest a mechanism for the absence of a fibrotic response to DOC/salt treatment in MyoMRKO mice.
Our finding that profibrotic gene expression (CTGF, Col III, and fibronectin) was not altered by loss of cardiomyocyte MR may reflect high vascular expression of these markers (shown by immunostaining) or a limited role for cardiomyocyte MR in their regulation. A novel finding in the present study is that the CTGF/TGFβ-inhibitory protein decorin was upregulated in MyoMRKO mice. Given that decorin is a negative regulator of CTGF and TGFβ114 and that loss of decorin is associated with significant tissue fibrosis,15 it is possible that elevated levels of this protein in the MyoMRKO mouse heart may serve to limit the profibrotic effects of CTGF and TGFβ1.
Gene expression of growth factors and markers of remodeling were significantly lower in MR-null cardiomyocytes. Of these, VEGFa and integrin-β1 remained low at 8 weeks. In particular, DOC/salt stimulation of VEGFa in WT mice was completely absent in MyoMRKO mice. Although a role for VEGFa regulation of capillary density has been described in ischemic remodeling, it is less well described in reactive fibrosis models; these data are consistent, however, with a role for VEGFa in tissue remodeling. Interestingly, a decorin-derived peptide has been shown to inhibit VEGF-stimulated NO release and endothelial cell migration in other model systems; decorin may thus play a broader role in the modulation of DOC/salt fibrosis.16
Per2 was selected for analysis, given that it is regulated by aldosterone in cardiomyocytes and that mice null for Per2 are protected from cardiac remodeling.17 Per2 was upregulated at 8 days of DOC/salt in WT but not MyoMRKO mice, suggesting a potential role for cardiomyocyte MR signaling in the modulation of clock genes, although detailed time-course studies are required to fully characterize this response. Given that the cardiomyocyte circadian clock influences myocardial gene expression, heart rate, function, and tolerance to reperfusion injury, Per2 may represent a novel contributor to DOC/salt-mediated cardiac pathology.18
Cardiomyocyte MRs and Inflammation
Cardiomyocyte MRs are important for the recruitment of inflammatory cells at 8 weeks but not 8 days. The parallel increase in macrophage number in both WT and MyoMRKO mice at 8 days is consistent with the role of vascular MR in the initial inflammatory infiltrate.5 Our data suggest that cardiomyocyte MR signaling may also regulate cell adhesion factor intercellular adhesion molecule-1 at baseline, but not in response to DOC/salt treatment as suggested previously.11,19 Although macrophage recruitment is maintained in MyoMRKO mice, oxidative stress (NOX2 and p22phox) and inflammatory markers (CCR5) are substantially lower than for WT mice, suggesting that the tissue response to the DOC/salt stress is already limited at this early stage.
At 8 weeks, the MyoMRKO hearts do not show the characteristic DOC/salt inflammatory cell infiltrate observed in WT mice. Our present data are thus consistent with our previous studies showing the importance of macrophage MR in cardiac remodeling.4 The mechanisms by which cardiomyocytes promote tissue fibrosis may therefore be macrophage dependent. Although decreased macrophage infiltration is associated with reduced tissue remodeling, our current data also show that a range of leukocytes play a role in DOC/salt cardiac pathology, that is, CD45+ leukocytes and CD8+ T cells that have previously been linked with tissue remodeling.20
Several proinflammatory genes not previously explored in the DOC/salt model, upregulation of CCR5 (chemokine for T-cell recruitment),21 CD14 (myeloid cell surface receptor),22 and CD81 (key regulatory protein on B cells and T cells),23,24 were lost in MyoMRKO mice. Although differential expression of these markers may reflect differences in immune cell infiltrate, these data offer further insights into the specific subsets of immune cells in the tissue remodeling process.
Cardiomyocyte MRs, Blood Pressure Regulation, and Cardiac Function
DOC/salt was associated with a positive inotropic effect in WT hearts only indicated by an increased developed pressure. A positive chronotropic effect of DOC/salt was also found for WT but not MyoMRKO mice (+Dp/dt and −Dp/dt; 2-tailed t test). These data are consistent with previous studies showing aldosterone-dependent increased factional shortening of cardiomyocytes and increased chronotropic responses in isolated cardiomyocytes.25–27 Although plasma volume contributes to developed pressure, the hypervolemia induced by DOC/salt is equivalent in WT and MyoMRKO mice, given that renal and vascular MR are intact. A lack of effect of fibrosis on cardiac relaxation is consistent with this stage of the model, which is has been selected to assess mediators of tissue remodeling. That cardiac function is normal in unchallenged mice shows that cardiac development is unaffected by the absence of MRs and is thus not compromised before the onset of the disease.9
DOC/salt treatment produced treatment effects on SBPs that were more marked in WT mice than MyoMRKO. However, SBP for MyoMRKO mice was not different from WT in either control or DOC/salt-treated mice, indicating that any effect on blood pressure by cardiomyocyte MR is modest. However, reduced atrial naturietic peptide (serum) and brain natriuretic peptide (mRNA) responses to DOC/salt suggest that the heart may be subject to less wall stress in MR-null mice.
Baseline Cardiac Responses to Deletion of MR Signaling
An important finding in the present study is the difference in gene expression profiles of untreated MyoMRKO mice compared with WT mice. Loss of MR signaling in cardiomyocytes resulted in significantly lower baseline levels of oxidative stress markers (p22phox), inflammatory markers (membrane cofactor protein-1, CCR5, CD14, and CD81), and profibrotic factors (plasminogen activation inhibitor 1, VEGFa, p22phox, TGFβ, and integrin β1). These data suggest an important role for the MR in cardiomyocyte signaling pathways responsible for these processes. Given that cardiomyocytes do not express 11βHSD2, expression of these genes may reflect glucocorticoid-bound MR.28 We recently described a similar pattern of expression for a set of proinflammatory and profibrotic genes in untreated monocyte/macrophage MR-null mice, further supporting a distinct role for glucocorticoid-occupied MRs in cardiac gene regulation.4
Clinical studies have demonstrated cardiac protection with MR antagonists in heart failure, although the cellular mechanisms are not fully understood. Previously, the MR has been shown to regulate leukocyte adhesion on endothelial cells5 and to promote a proinflammatory macrophage phenotype29; our data show that the cardiomyocyte MR regulates multiple stages of the DOC/salt inflammatory and fibrotic cardiac responses. The early responses to DOC/salt are suppressed in MR-null cardiomyocytes, which may be translated into a loss of the expanded tissue inflammatory response at 8 weeks and abrogation of tissue fibrosis. Our data highlight a specific role for cardiomyocyte MRs in the regulation of decorin levels and the CTGF-TGFβ pathway, and increase MMP2/MMP9 activity, together resulting in a net reduction in tissue fibrosis. Although a unique role for the cardiomyocyte MR in cardiac remodeling is consistent with observations of higher MR expression in failing heart tissue,30 it should be noted that although clinical studies show significantly greater cardiac mass in primary aldosteronism versus essential hypertension, left ventricular function has not been found to differ between these 2 patient groups.31 However, given that the majority of patients in the Randomized Aldactone Evaluation Study who benefited from MR blockade did not have high aldosterone levels, MR activation in the setting of left ventricular dysfunction may not be aldosterone dependent.
We are grateful to Prof Celso Gomez-Sanchez (University of Mississippi) for the kind gift of the MR 1–18 and MR 365 antibodies and to Profs Peter Fuller and John Funder (Prince Henry’s Institute) for their constructive input into the preparation of this manuscript. Prince Henry’s Institute data audit #11-02.
Sources of Funding
This work was supported by a National Health and Medical Research Council (Australia) Project Grant 388914 (M.J. Young) and by the Victorian Government’s Operational Infrastructure Support Program. A.J. Rickard was supported by a Monash University Graduate Scholarship.
The online-only Data Supplement is available with this article at http://hyper.ahajournals.org/lookup/suppl/doi:10.1161/HYPERTENSIONAHA.112.203158/-/DC1.
- Received July 27, 2012.
- Revision received August 2, 2012.
- Accepted September 6, 2012.
- © 2012 American Heart Association, Inc.
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Novelty and Significance
What Is New?
Cardiomyocyte MR activation plays a direct role in deoxycorticosterone/salt cardiac remodeling, independent of cardiac hypertrophy and systolic blood pressure.
Lack of cardiomyocyte MR limits early oxidative and inflammatory events which limits expansion of the tissue inflammatory response and fibrosis.
Increased decorin, a transforming growth factor β-inhibitory protein, in cardiomyocyte MR-null mice is a novel mechanism, whereby profibrotic signaling pathways may be regulated by a cell-specific MR.
What Is Relevant?
Cardiac histology and function in untreated cardiomyocyte MR-null mice is equivalent to wild-type mice showing that MR in these cells is not critical for cardiac development but is important for responses to disease stimuli.
Identification of the specific cellular mechanisms regulated by cardiomyocyte MRs may allow for the development of targeted therapies, such as tissue-selective MR blockers, that will provide cardiovascular protection but spare renal function.
Cardiomyocyte MRs play a critical role in initiation and developing tissue inflammation and collagen deposition via regulation of proinflammatory and profibrotic pathways in the heart.
Cardiomyocyte MR-null mice show normal tissue structure and function when unchallenged, highlighting the importance of the MR in promoting cardiovascular disease but not in maintaining normal cardiac development and function.


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Disclaimer: in 2013, my boyfriend and I went to Tuscany for a week, where we wanted to explore the landscape by means of a Vespa. We were given four day trips (no GPS involved, just regular drawn instructions, which meant I gave the directions and the boyfriend drove the Vespa), all of which started in the centre of San Gimignano, where we stayed at a hotel nearby.
Not a lot to be seen on today’s tour, though a lot to be tasted! Wine tastings with lunch in the above mentioned Montespertoli, a small mishap with the Vespa (whoopsie – though not my fault, luckily) and lovely dinner. Yesterday, dinner was actually on one of the panoramic view points, not in the centre of the city. Whoops. And it was delicious! If you ever go to San Gimignano, reserve a table on the terrace of Dulcis infundo and thank me later. It’s gorgeous food and an even better view.


text: John Covach (Professor of Music, University of Rochester and Eastman School of Music) received his Bachelor of Music (1983), Master of Music (1985), and PhD (1990) in music theory from the University of Michigan. He was also a Fulbright student in Vienna, Austria, in 1987-88. The recipient of several teaching awards and citations, Professor Covach teaches theory and analysis as well as courses in popular music. Since 1993, he has taught large lecture courses on rock at University of North Texas, University of North Carolina-Chapel Hill, and University of Rochester, and has lectured across North America and Europe. He is coeditor of Understanding Rock (Oxford 1997), American Rock and the Classical Music Tradition (Harwood 2000), and Institutions, Traditions, and American Popular Music (Harwood 2000). His extensive writings on twentieth-century music, popular music, and the philosophy of music have appeared in numerous books and journals. Professor Covach also maintains an active career as a performing and recording musician.


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4ft X 6ft 5ft X 8ft
Cowhide Patchwork Rug – Grey – FAST-PW561
Beautiful cowhide patchwork rug includes the forever collection of Gray, Black and white to make an extra ordinary combination, which in results make your flooring decoration, and wall works more prominent. Available in 4 ft X 6 ft and 5ft X 8ft.
- Material: 100% Genuine Cowhide
- Colors: Black, Grey & White
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text:
- London 2012: Tennis
Stunning Serena crushes Sharapova for Olympic gold
Serena Williams proved without any doubt she is the finest women's tennis player in the game by crushing Maria Sharapova to win the Olympic singles title and complete her career golden slam.
After a spell in the wilderness on account of injuries, Williams has returned to her best this year and proved the point with her Wimbledon title success last month. The only thing missing from her singles CV was an Olympic title and she set about putting that right in some style this week.
Williams progressed to the final for the loss of just 16 games, destroying the likes of Caroline Wozniacki and world No. 1 Victoria Azarenka, and she carried the form into the final with Sharapova - racing to a stunning 6-0 6-1 win.
The American set the tone in the opening game, firing down three aces - one of which was a second serve - in a love hold.
Sharapova has won four grand slams and is too one of the greats of her generation, but she was simply made to look like a second-rate player by the complete authority of Williams.
It was not until the third game that Sharapova won a point, but it proved a false dawn as Williams held - courtesy of a fourth ace - and she broke again for 4-0. And two games later, after only 30 minutes, the set was Williams'.
The dominance continued at the start of the second, with a glorious, precision backhand that landed flush on the line. It prompted a look of resignation from Sharapova who had worked the point well but could do nothing about the shot-play of her opponent.
Sharapova avoided the double bagel by getting on the board in the fourth game of the second set and winning a game appeared to imbue the Russian as she worked a couple of break points. But Williams was in no mood to let her opponent back into the match and fended off the threat before breaking serve to put herself within one game of victory.
And it was somewhat fitting, given how well she has served this week, that Williams secured gold on her own serve.

domain: sports


text:
During October 2023, the CIDG contributed to one new Cochrane Review in Issue 10, 2023 of the Cochrane Database of Systematic Reviews.
- Taylor M, Tapkigen J, Ali I, Liu Q, Long Q, Nabwera H. The impact of growth monitoring and promotion on health indicators in children under five years of age in low‐ and middle‐income countries. Cochrane Database of Systematic Reviews 2023, Issue 10. Art. No.: CD014785. DOI: 10.1002/14651858.CD014785.pub2. (Note: this Cochrane Review supersedes the published Cochrane Review Panpanich 1999).
The CIDG editorial base is located at the Liverpool School of Tropical Medicine in Liverpool, UK. Over 600 authors from some 52 countries contribute to the preparation of the Cochrane Reviews. They are supported by an international team of Editors, each with topic or methodological expertise. The CIDG’s main areas of work are on determination of the effects of interventions on the prevention or treatment infectious diseases of relevance to the United Nations Sustainable Development Goals.


Two Robot Chefs Make Omelets
(PhysOrg.com) -- No "house of the future" is complete without a household robot to do the cooking and cleaning. Although today´s robots still have a ways to go before substituting for a real live-in maid, researchers are working on their development.
It seems one of the most popular tasks for household robots is making omelets. Two recent robots - MotoMan SDA10 developed by Yaskawa Technology and Cogniron developed by researchers at the Ecole Polytechnique Federale de Lausanne (EPFL) - were both taught how to cook the perfect omelet.
At a recent robot fair in Osaka, Japan, Yaskawa Technology demonstrated Motoman SDA10 as it cooked an omelet, or "Okonomiyaki cake," in front of crowds. The humanoid mixed together the batter, eggs, cheese, and cabbage, and then flipped and fried the omelet. The company explained that a robot that has the flexibility to make omelets (Motoman SDA10 has seven axes of movement per arm) can also perform a variety of other jobs, such as assembling digital cameras.
Meanwhile, in Switzerland, researchers at EPFL's Learning Algorithms and Systems Laboratory (LASA) are developing a humanoid that progressively learns to cook an omelet from a human instructor. The Chief Cook Robot is part of the lab´s Cogniron (Cognitive Robot Companion) project.
Cogniron is intended to be not just a ready-made device, but an "artificial creature" that continually improves its abilities by acquiring new knowledge and skills. As a cook robot, the Cogniron remembers the exact movements as demonstrated by a human, and repeats the movements to perform tasks such as whipping eggs, cutting ham, and grating cheese.
EPFL's Learning Algorithms and Systems Laboratory: http://lasa.epfl.ch
via: Register Hardware
© 2008 PhysOrg.com


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By: Tamara Yajia
Scream is an Oscar Winning film about mean teens that make prank phone calls. Once I prank called my boss and told him he won a pepperoni pizza and he called me an asshole.
The movie starts with ghostman calling up Jewel Barrymort on her vintage phone. She says “wassup ‘ and he says “wassup, wassup? I ‘m watching you little lady, and you ‘re making tasty popcorn on the stove instead of the microwave and that is punishable by death. ‘
Then they play a fun game of movie trivia. He asks her who played the little girl in E.T, and she says “Ellen Degeneres, ‘ which is incorrect. Duhhhhh. Stupid. Everyone knows the girl in ET is Rodney Dangerfield. ‘
So the ghost kills her boyfriend who was getting a tan outside wearing many, many layers and sweating a lot. Womp womp. She runs away but scary mask guy gets her too. Poor Drool. Rest in peace. Now she won ‘t get to eat the popcorn.
Meanwhile Nerve Camel is a girl whos boyfriend climbs in window like ‘Clarissa Explains It All. ‘ They do making out on her bed, but she wants to stop. Boyfriend is so ready for doing it because her ponytail gives him the hornies, so he pouts and says “I have severe pain in my blue balls ‘ so she shows her mammaries and his balls go away. Thank god. ‘
Watch the video to see there rest of my beautiful review.


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Study 4 included 170 patients (87 BOTOX and 83 placebo) with upper limb spasticity who were at least 6 months post-stroke. In Study 4, patients received 20 Units of BOTOX into the adductor pollicis and flexor pollicis longus (total BOTOX dose =40 Units in thumb muscles) or placebo (see Table 30). Study 5 included 109 patients with upper limb spasticity who were at least 6 months post-stroke. In Study 5, patients received 15 Units (low dose) or 20 Units (high dose) of BOTOX into the adductor pollicis and flexor pollicis longus under EMG guidance (total BOTOX low dose =30 Units, total BOTOX high dose =40 Units), or placebo (see Table 30). The duration of follow-up in Study 4 and Study 5 was 12 weeks.
The other method of calculating the cost of Botox is to pay by the area being treated. Doctors will specify the total cost for a designated region of the face -- for example, in the United States it should cost between $250 and $500 to treat horizontal forehead lines. However, it’s important to note that the forehead is treated as two seperate areas--the forehead lines that run horizontally across the forehead, and the frown lines that appear at the glabella. If you were to pay per area treated you would need to pay for two different areas. This method of pricing can sometimes mean you pay for more than what you need, especially if you don’t have deeply-etched wrinkles. At the same time, there’s an advantage to knowing how much the treatment will cost before you undergo the procedure, leaving no room for any unwelcome surprises.
Forehead – The horizontal lines and furrows on your forehead will not magically disappear. Which is why you should consider getting a Botox injection before they start to set in permanently. These lines will become more excessive with age, and will age to your appearance.Over time by repeatedly injecting these lines the deeply etched lines will become progressively improved
Remember that the skill of the injector is extremely important when considering Botox injections. Because Botox can have some very obvious and embarrassing side effects like drooping eyelids, blurry vision, and excessive bruising around the injection site, it's important to consult with an experienced injector. Unlike dermal fillers which can be melted away with a follow-up injection of hyaluronidase, there's not much you can do about a bad Botox experience other than wait it out.
Botulism toxins are produced by bacteria of the genus Clostridium, namely Clostridium botulinum, C. butyricum, C. baratii and C. argentinense, which are widely distributed, including in soil and dust. As well, the bacteria can be found inside homes on floors, carpet, and countertops even after cleaning. Some food products such as honey can contain amounts of the bacteria.
In her talk, Lalvani expressed her intent to drive AMF’s mission forward by leveraging the expertise of the American Headache Society and incorporating more patient voices. The Move Against Migraine support community is essential to that goal, and AMF strives to be a trusted partner for support, resources and credible information for everyone in the community. The Move Against Migraine campaign was launched to raise awareness of migraine, but that’s only the beginning. Lalvani pointed to AMF’s advocacy and community-building efforts, specifically the response to Elle’s “Migraine Pose” article and robust partnership program. Whatever the platform and audience, AMF works to ensure the patient voice is always included and heard. Lalvani concluded her talk by stressing that patients have an important role to play as “drivers of change” and encouraged listeners to continue connecting with AMF. Check out our full library of Facebook Live recaps with some of the leading headache specialists and patient advocates in the country, and visit our resource library for more information on how you can better advocate for yourself and the migraine community.
“Most people in their twenties decide to try Botox simply because they want to enhance their appearance, such as relaxing the muscles in their forehead, or because they want to keep their skin looking fresh and young,” Shah says. “Starting earlier is better than later because as the lines get more and more embedded into the skin, Botox is not as effective in eliminating the lines.”
The cost of a Botox treatment is usually communicated as a flat cost, but can also be measured in individual injectable units. Each unit usually costs somewhere in the neighborhood of $15, but prices vary between geographic areas and between individual clinics. How many units are needed per treatment will depend on which areas of your face are being treated, and on your individual facial anatomy.
Spread of toxin effects.The effect of botulinum toxin may affect areas away from the injection site and cause serious symptoms including: loss of strength and all-over muscle weakness, double vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words clearly, loss of bladder control, trouble breathing, trouble swallowing.
Some industry insiders say it's not unusual, if still legally murky, for drug-company representatives and doctors to share information with one another about the different ways an approved drug may be used. If a doctor notices that, say, a treatment for crossed eyes also "takes the lines out," he may mention it to the representative from whom he buys the drugs. That rep may share that with another of his clients, and so on.
Though botulinum toxin is available under different names, Botox is the only one that is FDA-approved for migraine prevention. To be considered for Botox, patients must have migraines 15 days or more per month, which is considered chronic daily migraine. About 4 million Americans have such migraines, according to the Migraine Research Foundation. Also, patients must have tried and failed on at least 2 other medications first.


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Scam Tells Hudson Valley Residents They are Millionaires
Sorry to say, but if you were told over the phone you won almost $2 million, you were probably being scammed!
The Sullivan County Sheriff’s Office is alerting citizens to a new scam that is being attempted in the Hudson Valley. Residents are receiving phone calls from someone who claims to be from the Publishers Clearing House.
The caller tells the victim that he or she just won a prize of $1.9 million. The scammers then say that in order to receive the nearly $2 million prize they must pay a $350 processing fee. The victim is directed to send the fee in certified funds to a post office box in St. Croix, U.S. Virgin Islands.
There are few variations of the scam, where the target is told to send a money order, bank check or provide a credit card number, officials say.
The scammers are very aggressive, police say. In one case, a scammer called the victim for three straight days, until the victim agreed to send money.
Senior Citizens seem to be the scammer’s favorite target. Officials recommend you check on your elderly relatives and neighbors in order to prevent them from being scammed.


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Ron DeSantis Signs Bill Expanding School Choice to All Florida Students
The Florida governor has a history of using state power to bully Florida schools over speech he doesn't like. H.B. 1 may accomplish his goal while ceding power to parents.
Last week, Florida's Legislature passed H.B. 1, a bill that would expand the state's school choice program, the Family Empowerment Scholarship, to all Florida students. Today, Gov. Ron DeSantis signed the bill into law, a welcome change from his usual tendencies toward state authority.
Under current law, students can opt out of their local public school and attend a private or charter school using the state funding that would have otherwise gone to the local school. The program was primarily geared toward children with disabilities or those from low- or middle-income households, with eligibility capped at 375 percent of the poverty-level income. The new law would remove all eligibility caps but still prioritize lower-income students and those in foster care.
Speaking at Christopher Columbus High School, an all-boys Catholic school in Miami-Dade County, DeSantis called the bill a "game changer," saying it "will represent the largest expansion of education choice not only in the history of this state, but in the history of these United States."
Andrew Spar, president of the Florida Education Association (FEA), the state's teacher's union, excoriated the bill in a statement. Under H.B. 1, he contended, "average Floridians will be helping pay for millionaires and billionaires to send their kids to elite private schools." Of course, in either case, public schools are funded by tax money; in the absence of H.B. 1, those wealthy households would be paying those taxes plus private school tuition.
Under H.B. 1, participating private schools will still have to abide by certain requirements, like reporting grades to parents and administering certain state-approved standardized tests. But on balance, the bill will allow parents more control over their children's schooling by limiting the state's involvement. And given some of DeSantis' previous policy positions, that result was not a given.
In April 2022, DeSantis signed the Individual Freedom Act into law, more commonly known as the "Stop WOKE Act," which bans both schools and private businesses from endorsing certain ideas associated with critical race theory. At the time, he clearly signaled that the law's intent was to keep "the far-left woke agenda" out of his state's "schools and workplaces," a clear violation of free speech. Last week, a federal appeals court blocked the law from going into effect—and that wasn't the first federal court to do so.
In January, Florida's Department of Education rejected an Advanced Placement class in African American Studies from inclusion in school curriculum. DeSantis later defended the decision by saying, "Education is about the pursuit of truth, not the imposition of ideology or the advancement of a political agenda." Manny Diaz Jr., the state's education commissioner, called the class "woke indoctrination masquerading as education."
But school choice is the perfect method for contending with schools that teach what parents don't like. DeSantis' history may demonstrate a proclivity for using state power to bully people for their speech, but H.B. 1 may actually accomplish his goal while ceding power back to parents.